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Sample records for full-field laser-doppler imaging

  1. Real-time full field laser Doppler imaging

    NASA Astrophysics Data System (ADS)

    Leutenegger, Marcel; Harbi, Pascal; Thacher, Tyler; Raffoul, Wassim; Lasser, Theo

    2012-06-01

    We present a full field laser Doppler imaging instrument that enables real-time in vivo assessment of blood flow in dermal tissue and skin. The instrument monitors the blood perfusion in an area of about 50cm2 with 480 × 480 pixels per frame at a rate of 12-14 frames per second. Smaller frames can be monitored at much higher frame rates. We recorded the microcirculation in healthy skin before, during and after arterial occlusion. In initial clinical case studies, we imaged the microcirculation in burned skin and monitored the recovery of blood flow in a skin flap during reconstructive surgery indicating the high potential of LDI for clinical applications.

  2. Full-field high-speed laser Doppler imaging system for blood-flow measurements

    NASA Astrophysics Data System (ADS)

    Serov, Alexandre; Lasser, Theo

    2006-02-01

    We describe the design and performance of a new full-field high-speed laser Doppler imaging system developed for mapping and monitoring of blood flow in biological tissue. The total imaging time for 256x256 pixels region of interest is 1.2 seconds. An integrating CMOS image sensor is utilized to detect Doppler signal in a plurality of points simultaneously on the sample illuminated by a divergent laser beam of a uniform intensity profile. The integrating property of the detector improves the signal-to-noise ratio of the measurement, which results in high-quality flow-images provided by the system. The new technique is real-time, non-invasive and the instrument is easy to use. The wide range of applications is one of the major challenges for a future application of the imager. High-resolution high-speed laser Doppler perfusion imaging is a promising optical technique for diagnostic and assessing the treatment effect of the diseases such as e.g. atherosclerosis, psoriasis, diabetes, skin cancer, allergies, peripheral vascular diseases, skin irritancy and wound healing. We present some biological applications of the new imager and discuss the perspectives for the future implementations of the imager for clinical and physiological applications.

  3. Full-field laser Doppler imaging and its physiological significance for tissue blood perfusion

    NASA Astrophysics Data System (ADS)

    Binzoni, T.; Van DeVille, D.

    2008-12-01

    Using Monte Carlo simulations for a semi-infinite medium representing a skeletal muscle tissue, it is demonstrated that the zero- and first-order moments of the power spectrum for a representative pixel of a full-field laser-Doppler imager behave differently from classical laser-Doppler flowmetry. In particular, the zero-order moment has a very low sensitivity to tissue blood volume changes, and it becomes completely insensitive if the probability for a photon to interact with a moving red blood cell is above 0.05. It is shown that the loss in sensitivity is due to the strong forward scatter of the propagating photons in biological tissues (i.e., anisotropy factor g = 0.9). The first-order moment is linearly related to the root mean square of the red blood cell velocity (the Brownian component), and there is also a positive relationship with tissue blood volume. The most common physiological interpretation of the first-order moment is as tissue blood volume times expectation of the blood velocity (in probabilistic terms). In this sense, the use of the first-order moment appears to be a reasonable approach for qualitative real-time blood flow monitoring, but it does not allow us to obtain information on blood velocity or volume independently. Finally, it is shown that the spatial and temporal resolution trade-off imposed by the CMOS detectors, used in full-field laser-Doppler hardware, may lead to measurements that vary oppositely with the underlying physiological quantities. Further improvements on detectors' sampling rate will overcome this limitation.

  4. Laser Doppler flowmetry imaging

    NASA Astrophysics Data System (ADS)

    Nilsson, Gert E.; Wardell, Karin

    1994-02-01

    A laser Doppler perfusion imager has been developed that makes possible mapping of tissue blood flow over surfaces with extensions up to about 12 cm X 12 cm. The He-Ne laser beam scans the tissue under study throughout 4096 measurement sites. A fraction of the backscattered and Doppler broadened light is detected by a photo diode positioned about 20 cm above the tissue surface. After processing, a signal that scales linearly with perfusion is stored in a computer and a color coded image of the spatial tissue perfusion is shown on a monitor. A full format scan is completed in about 4.5 minutes. Algorithms for calculating perfusion profiles and averages as well as substraction of one image from another, form an integral part of the system data analysis software. The perfusion images can also be exported to other software packages for further processing and analysis.

  5. Laser Doppler Velocimetry and full-field soot volume fraction

    NASA Technical Reports Server (NTRS)

    Greenberg, Paul S.

    1995-01-01

    Since its introduction in the mid-sixties, Laser Doppler Velocimetry (LDV) has become one of the most widely used methods for the measurement of flows. Its remote and essentially non-intrusive nature provides an invaluable tool for a variety of difficult measurement situations which would be otherwise inaccessible. The high spatial resolution and rapid temporal response afforded by this technique are well suited to the determination of spatial and temporal details of flow fields, as well as characterization of turbulence. Advances in the understanding of the properties of LDV signals, accompanied by technological advances in coherent laser sources, detectors of high sensitivity and low noise, optical fabrication techniques and high-speed digital signal processing architectures have resulted in systems of increased accuracy and flexibility. As will be shown, recent progress in solid-state lasers and photo-detectors has been beneficial insofar as the compatibility of this method with the unique and severe constraints inherent in microgravity combustion science experiments.

  6. Laser Doppler imaging: usefulness in chronic pain medicine.

    PubMed

    Grothusen, John R; Schwartzman, Robert J

    2011-01-01

    Sympathetic nervous system dysfunction is thought to be a factor in neuropathic pain conditions such as Complex Regional Pain Syndrome and in vascular conditions such as Raynaud's phenomenon. Laser Doppler fluxmetry has been used as a fast non-invasive method to quantify changes in skin capillary blood flow which reflect activation of sympathetically mediated vasoconstriction of the arterioles that supply the capillaries. Studies of dynamic change of skin capillary blood flow with sympathetic activation such as cold or inspiratory gasp have generally used single point laser Doppler systems where the probe is in contact with the skin. The results are a single line tracing representing the capillary flow at a single point on the skin a few millimeters in diameter. Laser Doppler imaging (moorLDI laser Doppler imager, Moor Instruments Ltd.) allows for non-contact recording of skin blood flow of an area as large as 50 centimeters square with a resolution of 256 by 256 pixels and 4 milliseconds per pixel. Most work with laser Doppler imaging has studied changes that occur between successive scans. We have found it useful to look at changes that occur during a scan. In this way we obtain data that is comparable to the time resolution of single point laser Doppler methods, but with the larger spatial information that is available with laser Doppler imaging. We present a small series of case reports in which inspiratory gasp during laser Doppler imaging was able to provide quick, useful and unequivocal clinical information regarding the status of regional bilateral skin capillary response to sympathetic activation. This may be useful for distinguishing sympathetically mediated from sympathetically independent pain. We believe the methods described may provide the basis for future quantitative studies similar to those that use single point laser Doppler methods.

  7. Laser Doppler imaging for intraoperative human brain mapping.

    PubMed

    Raabe, A; Van De Ville, D; Leutenegger, M; Szelényi, A; Hattingen, E; Gerlach, R; Seifert, V; Hauger, C; Lopez, A; Leitgeb, R; Unser, M; Martin-Williams, E J; Lasser, T

    2009-02-15

    The identification and accurate location of centers of brain activity are vital both in neuro-surgery and brain research. This study aimed to provide a non-invasive, non-contact, accurate, rapid and user-friendly means of producing functional images intraoperatively. To this end a full field Laser Doppler imager was developed and integrated within the surgical microscope and perfusion images of the cortical surface were acquired during awake surgery whilst the patient performed a predetermined task. The regions of brain activity showed a clear signal (10-20% with respect to the baseline) related to the stimulation protocol which lead to intraoperative functional brain maps of strong statistical significance and which correlate well with the preoperative fMRI and intraoperative cortical electro-stimulation. These initial results achieved with a prototype device and wavelet based regressor analysis (the hemodynamic response function being derived from MRI applications) demonstrate the feasibility of LDI as an appropriate technique for intraoperative functional brain imaging.

  8. Laser Doppler perfusion monitoring and imaging of blood microcirculation

    NASA Astrophysics Data System (ADS)

    Nilsson, Gert E.; Wardell, Karin

    1994-07-01

    Laser Doppler perfusion monitoring is a method of assessing tissue perfusion based on measurements performed using Doppler broadening of monochromatic light scattered in moving blood cells. Ever since laser Doppler perfusion monitors became available about 15 years ago they have been used in numerous applications in both clinical and laboratory settings. The high spatial resolution has in practice manifested itself as one of the main limitations of the method. The reason for this is the difficulty in attaining reproducible values at successive measurement sites because most skin tissue possesses a substantial variation in blood flow even at adjacent measurement sites. In order to overcome this difficulty the laser Doppler perfusion imager was developed. In this camera-like device, the laser beam successively scans the tissue and the Doppler components of the backscattered light are detected by a remote photodiode. After a scanning procedure is complete, a color-coded perfusion map showing the spatial variation of skin blood flow is displayed on a monitor. The operating principle and early applications of this emerging technology are addressed in further detail.

  9. Burn depth assessments by photoacoustic imaging and laser Doppler imaging.

    PubMed

    Ida, Taiichiro; Iwazaki, Hideaki; Kawaguchi, Yasushi; Kawauchi, Satoko; Ohkura, Tsuyako; Iwaya, Keiichi; Tsuda, Hitoshi; Saitoh, Daizoh; Sato, Shunichi; Iwai, Toshiaki

    2016-03-01

    Diagnosis of burn depths is crucial to determine the treatment plan for severe burn patients. However, an objective method for burn depth assessment has yet to be established, although a commercial laser Doppler imaging (LDI) system is used limitedly. We previously proposed burn depth assessment based on photoacoustic imaging (PAI), in which thermoelastic waves originating from blood under the burned tissue are detected, and we showed the validity of the method by experiments using rat models with three different burn depths: superficial dermal burn, deep dermal burn and deep burn. On the basis of those results, we recently developed a real-time PAI system for clinical burn diagnosis. Before starting a clinical trial, however, there is a need to reveal more detailed diagnostic characteristics, such as linearity and error, of the PAI system as well as to compare its characteristics with those of an LDI system. In this study, we prepared rat models with burns induced at six different temperatures from 70 to 98 °C, which showed a linear dependence of injury depth on the temperature. Using these models, we examined correlations of signals obtained by PAI and LDI with histologically determined injury depths and burn induction temperatures at 48 hours postburn. We found that the burn depths indicated by PAI were highly correlative with histologically determined injury depths (depths of viable vessels) as well as with burn induction temperatures. Perfusion values measured by LDI were less correlative with these parameters, especially for burns induced at higher temperatures, being attributable to the limited detectable depth for light involving a Doppler shift in tissue. In addition, the measurement errors in PAI were smaller than those in LDI. On the basis of these results, we will be able to start clinical studies using the present PAI system.

  10. Comparison of laser Doppler and laser speckle contrast imaging using a concurrent processing system

    NASA Astrophysics Data System (ADS)

    Sun, Shen; Hayes-Gill, Barrie R.; He, Diwei; Zhu, Yiqun; Huynh, Nam T.; Morgan, Stephen P.

    2016-08-01

    Full field laser Doppler imaging (LDI) and single exposure laser speckle contrast imaging (LSCI) are directly compared using a novel instrument which can concurrently image blood flow using both LDI and LSCI signal processing. Incorporating a commercial CMOS camera chip and a field programmable gate array (FPGA) the flow images of LDI and the contrast maps of LSCI are simultaneously processed by utilizing the same detected optical signals. The comparison was carried out by imaging a rotating diffuser. LDI has a linear response to the velocity. In contrast, LSCI is exposure time dependent and does not provide a linear response in the presence of static speckle. It is also demonstrated that the relationship between LDI and LSCI can be related through a power law which depends on the exposure time of LSCI.

  11. See the brain at work: intraoperative laser Doppler functional brain imaging

    NASA Astrophysics Data System (ADS)

    Martin-Williams, E. J.; Raabe, A.; Van De Ville, D.; Leutenegger, M.; Szelényi, A.; Hattingen, E.; Gerlach, R.; Seifert, V.; Hauger, C.; Lopez, A.; Leitgeb, R.; Unser, M.; Lasser, T.

    2009-07-01

    During open brain surgery we acquire perfusion images non-invasively using laser Doppler imaging. The regions of brain activity show a distinct signal in response to stimulation providing intraoperative functional brain maps of remarkably strong contrast.

  12. Holographic laser Doppler imaging of microvascular blood flow.

    PubMed

    Magnain, C; Castel, A; Boucneau, T; Simonutti, M; Ferezou, I; Rancillac, A; Vitalis, T; Sahel, J A; Paques, M; Atlan, M

    2014-12-01

    We report on local superficial blood flow monitoring in biological tissue from laser Doppler holographic imaging. In time-averaging recording conditions, holography acts as a narrowband bandpass filter, which, combined with a frequency-shifted reference beam, permits frequency-selective imaging in the radio frequency range. These Doppler images are acquired with an off-axis Mach-Zehnder interferometer. Microvascular hemodynamic components mapping is performed in the cerebral cortex of the mouse and the eye fundus of the rat with near-infrared laser light without any exogenous marker. These measures are made from a basic inverse-method analysis of local first-order optical fluctuation spectra at low radio frequencies, from 0 Hz to 100 kHz. Local quadratic velocity is derived from Doppler broadenings induced by fluid flows, with elementary diffusing wave spectroscopy formalism in backscattering configuration. We demonstrate quadratic mean velocity assessment in the 0.1-10 mm/s range in vitro and imaging of superficial blood perfusion with a spatial resolution of about 10 micrometers in rodent models of cortical and retinal blood flow.

  13. Novel Applications of Laser Doppler Vibration Measurements to Medical Imaging

    NASA Astrophysics Data System (ADS)

    Tabatabai, Habib; Oliver, David E.; Rohrbaugh, John W.; Papadopoulos, Christopher

    2013-06-01

    Laser Doppler Vibrometry (LDV) has been widely used in engineering applications involving non-contact vibration and sound measurements. This technique has also been used in some biomedical applications including hearing research. The detectable frequencies are in the range of near-DC to 1 GHz or higher. This paper reviews applications of LDV in biomedical engineering and proposes new medical imaging applications based on measuring surface vibrations of tissues and organs. Tests were conducted on human skin using single point and scanning laser vibrometers. These tests suggest that skin vibrations due to the forcing excitation from the heart can be used in imaging of blood flow. The results of these tests illustrate the potential of such vibration measurements in a variety of diagnostic medical imaging applications including blood flow/restrictions, real-time monitoring of blood pressure variations, wound healing, muscle movements, etc. The fact that the measurements can be conducted remotely (non-contact) is an important benefit that adds to the promise of this approach.

  14. Seismic imaging in laboratory trough laser Doppler vibrometry

    NASA Astrophysics Data System (ADS)

    Brito, Daniel; Poydenot, Valier; Garambois, Stéphane; Diaz, Julien; Bordes, Clarisse; Rolando, Jean-Paul

    2016-04-01

    Mimic near-surface seismic field measurements at a small scale, in the laboratory, under a well-controlled environment, may lead to a better understanding of wave propagation in complex media such as in geological materials. Laboratory experiments can help in particular to constrain and refine theoretical and numerical modelling of physical phenomena occurring during seismic propagation, in order to make a better use of the complete set of measurements recorded in the field. We have developed a laser Doppler vibrometer (laser interferometry) platform designed to measure non-contact seismic displacements (or velocities) of a surface. This technology enables to measure displacements as small as a tenth of a nanometer on a wide range of frequencies, from a few tenths to a few megahertz. Our experimental set-up is particularly suited to provide high-density spatial and temporal records of displacements on the edge of any vibrating material. We will show in particular a study of MHz wave propagation (excited by piezoelectric transducers) in cylindrical cores of typical diameter size around 10 cm. The laser vibrometer measurements will be first validated in homogeneous materials cylinders by comparing the measurements to a direct numerical simulation. Special attention will be given to the comparison of experimental versus numerical amplitudes of displacements. In a second step, we will conduct the same type of study through heterogeneous carbonate cores, possibly fractured. Tomographic images of velocity in 2D slices of the carbonate core will be derived based upon on the time of first arrival. Preliminary attempts of tomographic attenuation maps will also be presented based on the amplitudes of first arrivals. Experimental records will be confronted to direct numerical simulations and tomographic images will be compared to x-ray scanner imaging of the cylindrical cores.

  15. The critical evaluation of laser Doppler imaging in determining burn depth.

    PubMed

    Gill, Parneet

    2013-01-01

    This review article discusses the use of laser Doppler imaging as a clinimetric tool to determine burn depth in patients presenting to hospital. Laser Doppler imaging is a very sensitive and specific tool to measure burn depth, easy to use, reliable and acceptable to the patient due to its quick and non-invasive nature. Improvements in validity, cost and reproducibility would improve its use in clinical practice however it is difficult to satisfy the entire evaluation criterion all the time. It remains a widely accepted tool to assess burn depth, with an ever-increasing body of evidence to support its use, as discussed in this review. Close collaboration between clinicians, statisticians, epidemiologists and psychologists is necessary in order to develop the evidence base for the use of laser Doppler imaging as standard in burn depth assessment and therefore act as an influencing factor in management decisions.

  16. Laser Doppler Perfusion Imaging with a high-speed CMOS-camera

    NASA Astrophysics Data System (ADS)

    Draijer, Matthijs J.; Hondebrink, Erwin; Steenbergen, Wiendelt; van Leeuwen, Ton G.

    2007-07-01

    The technique of Laser Doppler Perfusion Imaging (LDPI) is widely used for determining cerebral blood flow or skin perfusion in the case of burns. The commonly used Laser Doppler Perfusion Imagers are scanning systems which point by point scan the area under investigation and use a single photo detector to capture the photoelectric current to obtain a perfusion map. In that case the imaging time for a perfusion map of 64 x 64 pixels is around 5 minutes. Disadvantages of a long imaging time for in-vivo imaging are the bigger chance of movement artifacts, reduced comfort for the patient and the inability to follow fast changing perfusion conditions. We present a Laser Doppler Perfusion Imager which makes use of a high speed CMOS-camera. By illuminating the area under investigation and simultaneously taking images at high speed with the camera, it is possible to obtain a perfusion map of the area under investigation in a shorter period of time than with the commonly used Laser Doppler Perfusion Imagers.

  17. Laser Doppler holographic microscopy in transmission: application to fish embryo imaging.

    PubMed

    Verrier, Nicolas; Alexandre, Daniel; Gross, Michel

    2014-04-21

    We have extended Laser Doppler holographic microscopy to transmission geometry. The technique is validated with living fish embryos imaged by a modified upright bio-microcope. By varying the frequency of the holographic reference beam, and the combination of frames used to calculate the hologram, multimodal imaging has been performed. Doppler images of the blood vessels for different Doppler shifts, images where the flow direction is coded in RGB colors or movies showing blood cells individual motion have been obtained as well. The ability to select the Fourier space zone that is used to calculate the signal, makes the method quantitative. PMID:24787825

  18. High-speed wave-mixing laser Doppler imaging in vivo.

    PubMed

    Atlan, M; Gross, M; Vitalis, T; Rancillac, A; Rossier, J; Boccara, A C

    2008-04-15

    An interferometric method for parallel optical spectroscopy in the kilohertz range is reported, as well as its experimental validation in the context of high-speed laser Doppler imaging in vivo. The interferometric approach enables imaging in the low light conditions of a 2 kHz frame rate recording with a complementary metal-oxide semiconductor camera. Observation of mice craniums with near-infrared (lambda=785 nm) laser light in reflection configuration is reported. Doppler spectral images allegedly sensitive to blood flow are sequentially measured at several optical frequency detunings, to shift the spectral range of analysis in the radio-frequency spectrum.

  19. Laser Doppler blood flow complementary metal oxide semiconductor imaging sensor with analog on-chip processing

    SciTech Connect

    Gu Quan; Hayes-Gill, Barrie R.; Morgan, Stephen P

    2008-04-20

    A 4x4 pixel array with analog on-chip processing has been fabricated within a 0.35 {mu}m complementary metal oxide semiconductor process as a prototype sensor for laser Doppler blood flow imaging. At each pixel the bandpass and frequency weighted filters necessary for processing laser Doppler blood flow signals have been designed and fabricated. Because of the space constraints of implementing an accurate {omega}{sup 0.5} filter at the pixel level, this has been approximated using the ''roll off'' of a high-pass filter with a cutoff frequency set at 10 kHz. The sensor has been characterized using a modulated laser source. Fixed pattern noise is present that is demonstrated to be repeatable across the array and can be calibrated. Preliminary blood flow results on a finger before and after occlusion demonstrate that the sensor array provides the potential for a system that can be scaled to a larger number of pixels for blood flow imaging.

  20. Laser Doppler blood flow complementary metal oxide semiconductor imaging sensor with analog on-chip processing.

    PubMed

    Gu, Quan; Hayes-Gill, Barrie R; Morgan, Stephen P

    2008-04-20

    A 4 x 4 pixel array with analog on-chip processing has been fabricated within a 0.35 mum complementary metal oxide semiconductor process as a prototype sensor for laser Doppler blood flow imaging. At each pixel the bandpass and frequency weighted filters necessary for processing laser Doppler blood flow signals have been designed and fabricated. Because of the space constraints of implementing an accurate omega(0.5) filter at the pixel level, this has been approximated using the "roll off" of a high-pass filter with a cutoff frequency set at 10 kHz. The sensor has been characterized using a modulated laser source. Fixed pattern noise is present that is demonstrated to be repeatable across the array and can be calibrated. Preliminary blood flow results on a finger before and after occlusion demonstrate that the sensor array provides the potential for a system that can be scaled to a larger number of pixels for blood flow imaging.

  1. Laser doppler blood flow imaging using a CMOS imaging sensor with on-chip signal processing.

    PubMed

    He, Diwei; Nguyen, Hoang C; Hayes-Gill, Barrie R; Zhu, Yiqun; Crowe, John A; Gill, Cally; Clough, Geraldine F; Morgan, Stephen P

    2013-09-18

    The first fully integrated 2D CMOS imaging sensor with on-chip signal processing for applications in laser Doppler blood flow (LDBF) imaging has been designed and tested. To obtain a space efficient design over 64 × 64 pixels means that standard processing electronics used off-chip cannot be implemented. Therefore the analog signal processing at each pixel is a tailored design for LDBF signals with balanced optimization for signal-to-noise ratio and silicon area. This custom made sensor offers key advantages over conventional sensors, viz. the analog signal processing at the pixel level carries out signal normalization; the AC amplification in combination with an anti-aliasing filter allows analog-to-digital conversion with a low number of bits; low resource implementation of the digital processor enables on-chip processing and the data bottleneck that exists between the detector and processing electronics has been overcome. The sensor demonstrates good agreement with simulation at each design stage. The measured optical performance of the sensor is demonstrated using modulated light signals and in vivo blood flow experiments. Images showing blood flow changes with arterial occlusion and an inflammatory response to a histamine skin-prick demonstrate that the sensor array is capable of detecting blood flow signals from tissue.

  2. Laser Doppler Blood Flow Imaging Using a CMOS Imaging Sensor with On-Chip Signal Processing

    PubMed Central

    He, Diwei; Nguyen, Hoang C.; Hayes-Gill, Barrie R.; Zhu, Yiqun; Crowe, John A.; Gill, Cally; Clough, Geraldine F.; Morgan, Stephen P.

    2013-01-01

    The first fully integrated 2D CMOS imaging sensor with on-chip signal processing for applications in laser Doppler blood flow (LDBF) imaging has been designed and tested. To obtain a space efficient design over 64 × 64 pixels means that standard processing electronics used off-chip cannot be implemented. Therefore the analog signal processing at each pixel is a tailored design for LDBF signals with balanced optimization for signal-to-noise ratio and silicon area. This custom made sensor offers key advantages over conventional sensors, viz. the analog signal processing at the pixel level carries out signal normalization; the AC amplification in combination with an anti-aliasing filter allows analog-to-digital conversion with a low number of bits; low resource implementation of the digital processor enables on-chip processing and the data bottleneck that exists between the detector and processing electronics has been overcome. The sensor demonstrates good agreement with simulation at each design stage. The measured optical performance of the sensor is demonstrated using modulated light signals and in vivo blood flow experiments. Images showing blood flow changes with arterial occlusion and an inflammatory response to a histamine skin-prick demonstrate that the sensor array is capable of detecting blood flow signals from tissue. PMID:24051525

  3. Laser Doppler projection tomography.

    PubMed

    Zeng, Yaguang; Xiong, Ke; Lu, Xuanlong; Feng, Guanping; Han, Dingan; Wu, Jing

    2014-02-15

    We propose a laser Doppler projection tomography (LDPT) method to obtain visualization of three-dimensional (3D) flowing structures. With LDPT, the flowing signal is extracted by a modified laser Doppler method, and the 3D flowing image is reconstructed by the filtered backprojection algorithm. Phantom experiments are performed to demonstrate that LDPT is able to obtain 3D flowing structure with higher signal-to-noise ratio and spatial resolution. Our experiment results display its potentially useful application to develop 3D label-free optical angiography for the circulation system of live small animal models or microfluidic experiments.

  4. [Advances in the research of laser Doppler perfusion imaging in burn wounds].

    PubMed

    Liu, Jing; Xu, Longshun; Hu, Dahai; Qu, Yi; Wang, Guodong; Wang, Hongtao

    2014-04-01

    Laser Doppler perfusion imaging (LDPI) works through the Doppler effect of light wave, and it could depict the blood flow value of the entire wound in two-dimensional image without contacting the detection site directly. In resent years, LDPI has been proved to be effective to evaluate healing potential of a wound, and to predict burn depth and scar formation. The accuracy of LDPI is higher than other traditional methods and technique. However, there are still many influencing factors for the clinical application of LDPI scanning. This paper presents a comprehensive overview of advances in the research of LDPI for clinical application in the care of burn wounds and influencing factors for accurate scanning. PMID:24989665

  5. Correlation between percutaneous penetration of methyl nicotinate and sensitive skin, using laser Doppler imaging.

    PubMed

    Issachar, N; Gall, Y; Borrel, M T; Poelman, M C

    1998-10-01

    Cutaneous penetration of methyl nicotinate has been investigated in 20 women divided into reactors and non-reactors on the basis of response to 10% aqueous solution of lactic acid. The vasodilation induced was measured using a laser Doppler perfusion imager (LDPI) every 5 min for 1 h after application of methyl nicotinate. The intensity and duration of inflammation generated by methyl nicotinate were used to assess penetration of this chemical in persons with sensitive skin compared to those with normal skin. Significant differences were found between reactors and non-reactors. Reactors showed a significantly increased intensity of response to methyl nicotinate as early as 5 min after application, and for 30 min afterwards, though the duration of inflammation in these 2 groups was the same. Correlation between increased penetration of methyl nicotinate and skin response to lactic acid may suggest increased penetration of water-soluble chemicals in individuals with sensitive skin.

  6. Evaluation of the microcirculation in a rabbit hemorrhagic shock model using laser Doppler imaging.

    PubMed

    Luo, Zhenchun; Wang, Pengfei; Zhang, An; Zuo, Guoqing; Zheng, Yuanyi; Huang, Yan

    2015-01-01

    The aim of this study is to evaluate the feasibility of Laser Doppler imaging (LDI) for noninvasive and dynamic assessment of hemorrhagic shock in a rabbit model. A rabbit model of hemorrhagic shock was generated and LDI of the microcirculation in the rabbit ears was performed before and at 0, 30, 60, and 90 min after hemorrhage. The CCD (Charge Coupled Device) image of the ears, the mean arterial pressure (MAP) and the heart rate (HR) were monitored. The mean LDI flux was calculated. The HR of rabbits was significantly (p < 0.05) elevated and the MAP was decreased after hemorrhage, compared to the pre-hemorrhage level. Within the initial 30 min after hemorrhage, the perfusion flux lineally dropped down. In contrast, the MAP values did not differ significantly between the time points of 0 and 30 after hemorrhage (p > 0.05). Both the flux numbers and the red-to-blue color changes on LDI imaging showed the reduction of the microcirculation. LDI imaging is a noninvasive and non-contact approach to evaluate the microcirculation and may offer benefits in the diagnosis and treatment of hemorrhage shock. Further studies are needed to confirm its effectiveness in clinical practice.

  7. 3D elemental sensitive imaging by full-field XFCT.

    PubMed

    Deng, Biao; Du, Guohao; Zhou, Guangzhao; Wang, Yudan; Ren, Yuqi; Chen, Rongchang; Sun, Pengfei; Xie, Honglan; Xiao, Tiqiao

    2015-05-21

    X-ray fluorescence computed tomography (XFCT) is a stimulated emission tomography modality that maps the three-dimensional (3D) distribution of elements. Generally, XFCT is done by scanning a pencil-beam across the sample. This paper presents a feasibility study of full-field XFCT (FF-XFCT) for 3D elemental imaging. The FF-XFCT consists of a pinhole collimator and X-ray imaging detector with no energy resolution. A prototype imaging system was set up at the Shanghai Synchrotron Radiation Facility (SSRF) for imaging the phantom. The first FF-XFCT experimental results are presented. The cadmium (Cd) and iodine (I) distributions were reconstructed. The results demonstrate FF-XFCT is fit for 3D elemental imaging and the sensitivity of FF-XFCT is higher than a conventional CT system.

  8. Application of a new laser Doppler imaging system in planning and monitoring of surgical flaps

    NASA Astrophysics Data System (ADS)

    Schlosser, Stefan; Wirth, Raphael; Plock, Jan A.; Serov, Alexandre; Banic, Andrej; Erni, Dominique

    2010-05-01

    There is a demand for technologies able to assess the perfusion of surgical flaps quantitatively and reliably to avoid ischemic complications. The aim of this study is to test a new high-speed high-definition laser Doppler imaging (LDI) system (FluxEXPLORER, Microvascular Imaging, Lausanne, Switzerland) in terms of preoperative mapping of the vascular supply (perforator vessels) and postoperative flow monitoring. The FluxEXPLORER performs perfusion mapping of an area 9×9 cm with a resolution of 256×256 pixels within 6 s in high-definition imaging mode. The sensitivity and predictability to localize perforators is expressed by the coincidence of preoperatively assessed LDI high flow spots with intraoperatively verified perforators in nine patients. 18 free flaps are monitored before, during, and after total ischemia. 63% of all verified perforators correspond to a high flow spot, and 38% of all high flow spots correspond to a verified perforator (positive predictive value). All perfused flaps reveal a value of above 221 perfusion units (PUs), and all values obtained in the ischemic flaps are beneath 187 PU. In summary, we conclude that the present LDI system can serve as a reliable, fast, and easy-to-handle tool to detect ischemia in free flaps, whereas perforator vessels cannot be detected appropriately.

  9. Holographic laser Doppler ophthalmoscopy.

    PubMed

    Simonutti, M; Paques, M; Sahel, J A; Gross, M; Samson, B; Magnain, C; Atlan, M

    2010-06-15

    We report laser Doppler ophthalmoscopic fundus imaging in the rat eye with near-IR heterodyne holography. Sequential sampling of the beat of the reflected radiation against a frequency-shifted optical local oscillator is made onto an array detector. Wide-field maps of fluctuation spectra in the 10 Hz to 25 kHz band exhibit angiographic contrasts in the retinal vascular tree without requirement of an exogenous marker.

  10. Coma full-field display for freeform imaging systems

    NASA Astrophysics Data System (ADS)

    Bauer, Aaron; Thompson, Kevin P.; Rolland, Jannick P.

    2015-10-01

    With the recent advances in optical fabrication technology, the manufacturing of freeform optical surfaces is no longer prohibitive. To spur the development of freeform systems, however, optical designers must be given the necessary tools to efficiently design, analyze, and tolerance these systems. The process for designing freeform imaging systems is enhanced by the knowledge of the individual aberration contributions across the full field-of-view. As shown in the recent aberration theory for freeform surfaces, identifying the field dependence of the dominant aberrations is critical for a controlled freeform optimization. Coma, an often system-limiting aberration and an aberration that has recently been directly addressed with freeform surfaces, is of specific interest. Currently, a coma full-field display (FFD) of a system can be generated in commercial ray-tracing software by fitting the wavefront at the exit pupil with Zernike polynomials, but this process can involve tracing thousands of rays. Moreover, the circular coma FFDs are inherently separate from the elliptical coma FFDs. In this research, we use nodal aberration theory to develop a method to generate a coma FFD that requires only a few (less than 10) rays per field point to be traced through the optical system. Both the magnitude and orientation of the coma aberrations at the image plane are shown in our FFDs, including the effects of elliptical coma. These coma FFDs save computation time during the design and offer valuable insight to the designer. Examples of the plots will be shown for multiple freeform optical systems.

  11. Laser Doppler perfusion imaging: a method for measuring female sexual response.

    PubMed

    Styles, S J; Maclean, A B; Reid, W M N; Sultana, S R

    2006-05-01

    To develop a new noninvasive technique to measure vulval blood flow changes during sexual arousal; 18 healthy volunteers between the age of 20 and 33 years were studied. Each subject underwent two experimental sessions at least 2 weeks apart to coincide with the proliferative and luteal phases of her menstrual cycle. An initial laser Doppler perfusion imaging (LDPI) scan of the vulva was performed. The subject was then given a chapter of erotic fiction to read and a repeat LDPI scan was performed immediately after. The percentage change in flux were calculated: the clitoral skin blood flow increased by 26.4% (P < 0.05), labial skin blood flow by 24.9% (P < 0.05) and the posterior fourchette skin blood flow by 35.3% (P < 0.05). LDPI can detect changes in vulval perfusion during the sexual arousal response and could be used to compare healthy subjects with female sexual dysfunction patients, as well as for assessing the benefits of any treatment for this condition. PMID:16637901

  12. Terahertz imaging using full-field electrooptic sampling

    NASA Astrophysics Data System (ADS)

    Ayesheshim, Ayesheshim Kebie

    Real time terahertz imaging is emerging as an important non-destructive imaging tool for medical, quality control, security and other industrial applications. In this thesis, we demonstrate real-time full-field terahertz (THz) imaging of still, moving, and concealed objects, and real-time THz images of the field distribution on the imaging plane. A femtosecond laser pulse from an amplified Ti:sapphire laser system with a pulse duration of 100 fs, repetition rate of 1 kHz, and 800 nm center wavelength is used to generate THz pulses via optical rectification in a 15x15 mm2 by 2 mm thick [110] ZnTe crystal. The THz pulses are collimated to a 1" diameter beam using off-axis parabolic reflectors. An object is placed in the collimated THz beam, and a plastic lens is used to form an image of the object on a second ZnTe crystal (detector). The THz image is detected by free-space electro-optic sampling using a large diameter gating beam derived from the laser source. Video or still images are captured by an 8-bit (30 fps) grayscale CCD camera, and objects hidden behind paper or inside Styrofoam can be clearly seen in real-time. We also study the ring-like spatial intensity distribution of the various frequency components of the THz pulse focused in the image plane by varying the time-delay between the THz and probe beams. Methods for improving signal-to-noise such as frame averaging and dynamic subtraction are also studied.

  13. Dynamic full-field infrared imaging with multiple synchrotron beams

    PubMed Central

    Stavitski, Eli; Smith, Randy J.; Bourassa, Megan W.; Acerbo, Alvin S.; Carr, G. L.; Miller, Lisa M.

    2013-01-01

    Microspectroscopic imaging in the infrared (IR) spectral region allows for the examination of spatially resolved chemical composition on the microscale. More than a decade ago, it was demonstrated that diffraction limited spatial resolution can be achieved when an apertured, single pixel IR microscope is coupled to the high brightness of a synchrotron light source. Nowadays, many IR microscopes are equipped with multi-pixel Focal Plane Array (FPA) detectors, which dramatically improve data acquisition times for imaging large areas. Recently, progress been made toward efficiently coupling synchrotron IR beamlines to multi-pixel detectors, but they utilize expensive and highly customized optical schemes. Here we demonstrate the development and application of a simple optical configuration that can be implemented on most existing synchrotron IR beamlines in order to achieve full-field IR imaging with diffraction-limited spatial resolution. Specifically, the synchrotron radiation fan is extracted from the bending magnet and split into four beams that are combined on the sample, allowing it to fill a large section of the FPA. With this optical configuration, we are able to oversample an image by more than a factor of two, even at the shortest wavelengths, making image restoration through deconvolution algorithms possible. High chemical sensitivity, rapid acquisition times, and superior signal-to-noise characteristics of the instrument are demonstrated. The unique characteristics of this setup enabled the real time study of heterogeneous chemical dynamics with diffraction-limited spatial resolution for the first time. PMID:23458231

  14. Full field imaging based instantaneous hyperspectral absolute refractive index measurement

    SciTech Connect

    Baba, Justin S; Boudreaux, Philip R

    2012-01-01

    Multispectral refractometers typically measure refractive index (RI) at discrete monochromatic wavelengths via a serial process. We report on the demonstration of a white light full field imaging based refractometer capable of instantaneous multispectral measurement of absolute RI of clear liquid/gel samples across the entire visible light spectrum. The broad optical bandwidth refractometer is capable of hyperspectral measurement of RI in the range 1.30 1.70 between 400nm 700nm with a maximum error of 0.0036 units (0.24% of actual) at 414nm for a = 1.50 sample. We present system design and calibration method details as well as results from a system validation sample.

  15. Investigation of contact acoustic nonlinearity in delaminations by shearographic imaging, laser doppler vibrometric scanning and finite difference modeling.

    PubMed

    Sarens, Bart; Verstraeten, Bert; Glorieux, Christ; Kalogiannakis, Georgios; Van Hemelrijck, Danny

    2010-06-01

    Full-field dynamic shearography and laser Doppler vibrometric scanning are used to investigate the local contact acoustic nonlinear generation of delamination-induced effects on the vibration of a harmonically excited composite plate containing an artificial defect. Nonlinear elastic behavior caused by the stress-dependent boundary conditions at the delamination interfaces of a circular defect is also simulated by a 3-D second-order, finite-difference, staggered-grid model (displacement-stress formulation). Both the experimental and simulated data reveal an asymmetric motion of the layer above the delamination, which acts as a membrane vibrating with enhanced displacement amplitude around a finite offset displacement. The spectrum of the membrane motion is enriched with clapping-induced harmonics of the excitation frequency. In case of a sufficiently thin and soft membrane, the simulations reveal clear modal behavior at sub-harmonic frequencies caused by inelastic clapping. PMID:20529713

  16. Effects of permanent magnets on resting skin blood perfusion in healthy persons assessed by laser Doppler flowmetry and imaging.

    PubMed

    Mayrovitz, H N; Groseclose, E E; Markov, M; Pilla, A A

    2001-10-01

    Effects on skin blood perfusion of permanent ceramic magnets [0.1 T (1000 G) surface field], individually (disk shaped, 4 cm diameter x 1 cm thick) or in the form of a 11 x 7 in pad ( approximately 28 x 17.8 cm) with an array of 16 rectangular magnets (4.5 x 2.2 cm), were investigated in 16 female volunteers (27.4 +/- 1.7 years, range 21-48 years) using three separate protocols. In protocol A, a disk magnet was placed on the palmar surface of the hand in contact with the thenar eminence (n = 5). In protocol B, the magnet was placed on the hand dorsum overlying the thenar eminence (n = 5). In protocol C, the entire palm and fingers rested on the magnetic pad (n = 6). Magnets were in place for 36 min on one hand, and a sham was in place on the other hand. Blood perfusion was measured on the middle finger dorsum by laser Doppler flowmetry (LDF) and on the index finger by laser Doppler imaging (LDI). Perfusion measurements were simultaneously taken in sham and magnet exposed hands, before and during the entire magnet exposure interval. Magnetic field effects were tested by comparing skin blood perfusion sequences in magnet and sham exposed regions. Results showed no significant changes in either LDF or LDI perfusion at magnet or sham sites during exposure, nor were there any significant differences between sham and magnet sites for any protocol. Measurements of skin temperature at the LDF measurement sites also showed no significant change. It is concluded that in the healthy subjects studied with normal, unstressed circulation, magnets of the type and for the duration used, showed no detectible effect on skin blood perfusion in the anatomical area studied.

  17. Automated registration of laser Doppler perfusion images by an adaptive correlation approach: application to focal cerebral ischemia in the rat.

    PubMed

    Riyamongkol, Panomkhawn; Zhao, Weizhao; Liu, Yitao; Belayev, Ludmila; Busto, Raul; Ginsberg, Myron D

    2002-12-31

    Hemodynamic changes are extremely important in analyzing responses from a brain subjected to a stimulus or treatment. The Laser Doppler technique has emerged as an important tool in neuroscience research. This non-invasive method scans a low-power laser beam in a raster pattern over a tissue surface to generate the time course of images in unit of relative flux changes. Laser Doppler imager (LDI) records cerebral perfusion not only in the temporal but also in the spatial domain. The traditional analysis of LD images has been focused on the region-of-interest (ROI) approach, in which the analytical accuracy in an experiment that necessitates a relative repositioning between the LDI and the scanned tissue area will be weakened due to the operator's subjective decision in data collecting. This report describes a robust image registration method designed to obviate this problem, which is based on the adaptive correlation approach. The assumption in mapping corresponding pixels in two images is to correlate the regions in which these pixels are centered. Based on this assumption, correlation coefficients are calculated between two regions by a method in which one region is moved around over the other in all possible combinations. To avoid ambiguity in distinguishing maximum correlation coefficients, an adaptive algorithm is adopted. Correspondences are then used to estimate the transformation by linear regression. We used a pair of phantom LD images to test this algorithm. A reliability test was also performed on each of the 15 sequential LD images derived from an actual experiment by imposing rotation and translation. The result shows that the calculated transformation parameters (rotation: theta =7.7+/-0.5 degrees; translation: Delta x =2.8+/-0.3, Deltaŷ=4.7+/-0.4) are very close to the prior-set parameters (rotation: theta=8 degrees; translation: Delta x=3, Delta y=5). This result indicates that this approach is a valuable adjunct to LD perfusion monitoring. An

  18. Low-Power CMOS Laser Doppler Imaging Using Non-CDS Pixel Readout and 13.6-bit SAR ADC.

    PubMed

    Chen, Denis Guangyin; Law, Man-Kay; Lian, Yong; Bermak, Amine

    2016-02-01

    Laser Doppler imaging (LDI) measures particle flows such as blood perfusion by sensing their Doppler shift. This paper is the first of its kind in analyzing the effect of circuit noise on LDI precision which is distinctively different from conventional imaging. Based on this result, it presents a non-correlated-double-sampling (non-CDS) pixel readout scheme along with a high-resolution successive-approximation-register (SAR) analog-to-digital-converter (ADC) with 13.6b effective resolution (ER). Measurement results from the prototype chip in 0.18 μm technology confirm the theoretical analysis and show that the two techniques improve LDI sensing precision by 6.9 dB and 4.4 dB (compared to a 10b ADC) respectively without analog pre-amplification. The sensor's ADC occupies 518 μm×84 μm and is suitable for fast column parallel readout. Its differential non-linearity (DNL), integral non-linearity (INL), and input referred noise are +3.0/-2.8 LSB, +24/-17 LSB, and 110 μVrms respectively, leading to a Figure-of-Merit (FoM) of 23 fJ/state which makes it one of the most energy efficient image sensor ADCs and an order of magnitude better than the best reported LDI system using commercial high-speed image sensors.

  19. Low-Power CMOS Laser Doppler Imaging Using Non-CDS Pixel Readout and 13.6-bit SAR ADC.

    PubMed

    Chen, Denis Guangyin; Law, Man-Kay; Lian, Yong; Bermak, Amine

    2016-02-01

    Laser Doppler imaging (LDI) measures particle flows such as blood perfusion by sensing their Doppler shift. This paper is the first of its kind in analyzing the effect of circuit noise on LDI precision which is distinctively different from conventional imaging. Based on this result, it presents a non-correlated-double-sampling (non-CDS) pixel readout scheme along with a high-resolution successive-approximation-register (SAR) analog-to-digital-converter (ADC) with 13.6b effective resolution (ER). Measurement results from the prototype chip in 0.18 μm technology confirm the theoretical analysis and show that the two techniques improve LDI sensing precision by 6.9 dB and 4.4 dB (compared to a 10b ADC) respectively without analog pre-amplification. The sensor's ADC occupies 518 μm×84 μm and is suitable for fast column parallel readout. Its differential non-linearity (DNL), integral non-linearity (INL), and input referred noise are +3.0/-2.8 LSB, +24/-17 LSB, and 110 μVrms respectively, leading to a Figure-of-Merit (FoM) of 23 fJ/state which makes it one of the most energy efficient image sensor ADCs and an order of magnitude better than the best reported LDI system using commercial high-speed image sensors. PMID:25532189

  20. Concurrent Reflectance Confocal Microscopy and Laser Doppler Flowmetry to Improve Skin Cancer Imaging: A Monte Carlo Model and Experimental Validation.

    PubMed

    Mowla, Alireza; Taimre, Thomas; Lim, Yah Leng; Bertling, Karl; Wilson, Stephen J; Prow, Tarl W; Soyer, H Peter; Rakić, Aleksandar D

    2016-01-01

    Optical interrogation of suspicious skin lesions is standard care in the management of skin cancer worldwide. Morphological and functional markers of malignancy are often combined to improve expert human diagnostic power. We propose the evaluation of the combination of two independent optical biomarkers of skin tumours concurrently. The morphological modality of reflectance confocal microscopy (RCM) is combined with the functional modality of laser Doppler flowmetry, which is capable of quantifying tissue perfusion. To realize the idea, we propose laser feedback interferometry as an implementation of RCM, which is able to detect the Doppler signal in addition to the confocal reflectance signal. Based on the proposed technique, we study numerical models of skin tissue incorporating two optical biomarkers of malignancy: (i) abnormal red blood cell velocities and concentrations and (ii) anomalous optical properties manifested through tissue confocal reflectance, using Monte Carlo simulation. We also conduct a laboratory experiment on a microfluidic channel containing a dynamic turbid medium, to validate the efficacy of the technique. We quantify the performance of the technique by examining a signal to background ratio (SBR) in both the numerical and experimental models, and it is shown that both simulated and experimental SBRs improve consistently using this technique. This work indicates the feasibility of an optical instrument, which may have a role in enhanced imaging of skin malignancies. PMID:27598157

  1. Structure of a swirl-stabilized spray flame by imaging, laser Doppler velocimetry, and phase Doppler anemometry

    NASA Technical Reports Server (NTRS)

    Edwards, C. F.; Rudoff, R. C.

    1991-01-01

    Data are presented which describe the mean structure of a steady, swirl-stabilized, kerosene spray flame in the near-injector region of a research furnace. The data presented include ensemble-averaged results of schlieren, luminosity, and extinction imaging, measurement of the gas phase velocity field by laser Doppler velocimetry, and characterization of the condensed phase velocity by phase Doppler anemometry. The results of these studies define six key regions in the flame: the dense spray region; the rich, two-phase, fuel jet; the main air jet; the internal product recirculation zone; the external product recirculation zone; and the gaseous diffusion flame zone. The first five of these regions form a conical mixing layer which prepares the air and fuel for combustion. The air and fuel jets comprise the central portion of this mixing layer and are bounded on either side by the hot product gases of the internal and external recirculation zones. Entrainment of these product gases into the air/fuel streams provides the energy required to evaporate the fuel spray and initiate combustion. Intermittency of the internal recirculation and spray jet flows accounts for unexpected behavior observed in the aerodynamics of the two phases. The data reported herein are part of the database being accumulated on this spray flame for the purpose of detailed comparison with numerical modeling.

  2. Concurrent Reflectance Confocal Microscopy and Laser Doppler Flowmetry to Improve Skin Cancer Imaging: A Monte Carlo Model and Experimental Validation

    PubMed Central

    Mowla, Alireza; Taimre, Thomas; Lim, Yah Leng; Bertling, Karl; Wilson, Stephen J.; Prow, Tarl W.; Soyer, H. Peter; Rakić, Aleksandar D.

    2016-01-01

    Optical interrogation of suspicious skin lesions is standard care in the management of skin cancer worldwide. Morphological and functional markers of malignancy are often combined to improve expert human diagnostic power. We propose the evaluation of the combination of two independent optical biomarkers of skin tumours concurrently. The morphological modality of reflectance confocal microscopy (RCM) is combined with the functional modality of laser Doppler flowmetry, which is capable of quantifying tissue perfusion. To realize the idea, we propose laser feedback interferometry as an implementation of RCM, which is able to detect the Doppler signal in addition to the confocal reflectance signal. Based on the proposed technique, we study numerical models of skin tissue incorporating two optical biomarkers of malignancy: (i) abnormal red blood cell velocities and concentrations and (ii) anomalous optical properties manifested through tissue confocal reflectance, using Monte Carlo simulation. We also conduct a laboratory experiment on a microfluidic channel containing a dynamic turbid medium, to validate the efficacy of the technique. We quantify the performance of the technique by examining a signal to background ratio (SBR) in both the numerical and experimental models, and it is shown that both simulated and experimental SBRs improve consistently using this technique. This work indicates the feasibility of an optical instrument, which may have a role in enhanced imaging of skin malignancies. PMID:27598157

  3. Concurrent Reflectance Confocal Microscopy and Laser Doppler Flowmetry to Improve Skin Cancer Imaging: A Monte Carlo Model and Experimental Validation.

    PubMed

    Mowla, Alireza; Taimre, Thomas; Lim, Yah Leng; Bertling, Karl; Wilson, Stephen J; Prow, Tarl W; Soyer, H Peter; Rakić, Aleksandar D

    2016-09-01

    Optical interrogation of suspicious skin lesions is standard care in the management of skin cancer worldwide. Morphological and functional markers of malignancy are often combined to improve expert human diagnostic power. We propose the evaluation of the combination of two independent optical biomarkers of skin tumours concurrently. The morphological modality of reflectance confocal microscopy (RCM) is combined with the functional modality of laser Doppler flowmetry, which is capable of quantifying tissue perfusion. To realize the idea, we propose laser feedback interferometry as an implementation of RCM, which is able to detect the Doppler signal in addition to the confocal reflectance signal. Based on the proposed technique, we study numerical models of skin tissue incorporating two optical biomarkers of malignancy: (i) abnormal red blood cell velocities and concentrations and (ii) anomalous optical properties manifested through tissue confocal reflectance, using Monte Carlo simulation. We also conduct a laboratory experiment on a microfluidic channel containing a dynamic turbid medium, to validate the efficacy of the technique. We quantify the performance of the technique by examining a signal to background ratio (SBR) in both the numerical and experimental models, and it is shown that both simulated and experimental SBRs improve consistently using this technique. This work indicates the feasibility of an optical instrument, which may have a role in enhanced imaging of skin malignancies.

  4. The use of laser Doppler imaging as an aid in clinical management decision making in the treatment of vesicant burns.

    PubMed

    Brown, R F; Rice, P; Bennett, N J

    1998-12-01

    Vesicants are a group of chemicals recognised, under the terms of the Chemical Weapons Convention, as potential chemical warfare agents whose prime effect on the skin is to cause burns and blistering. Experience of the clinical management of these injuries is not readily available and therefore an accurate assessment of the severity of the lesion and extent of tissue involvement is an important factor when determining the subsequent clinical management strategy for such lesions. This study was performed to assess the use of laser Doppler imaging (LDI) as a noninvasive means of assessing wound microvascular perfusion following challenge with the vesicant agents (sulphur mustard or lewisite) by comparing the images obtained with histopathological analysis of the lesion. Large white pigs were challenged with sulphur mustard (1.91 mg cm(-2)) or lewisite (0.3 mg.cm(-2)) vapour for periods of up to 6 h At intervals of between 1 h and 7 days following vesicant challenge, LDI images were acquired and samples for routine histopathology were taken. The results from this study suggest that LDI was: (i) a simple, reproducible and noninvasive means of assessing changes in tissue perfusion, and hence tissue viability, in developing and healing vesicant burns; (ii) the LDI images correlates well with histopathological assessment of the resulting lesions and the technique was sufficiently sensitive enough to discriminate between skin lesions of different aetiology. These attributes suggest that LDI would be a useful investigative tool that could aid clinical management decision making in the early treatment of vesicant agent-induced skin burns.

  5. Ultrasound assessed thickness of burn scars in association with laser Doppler imaging determined depth of burns in paediatric patients.

    PubMed

    Wang, Xue-Qing; Mill, Julie; Kravchuk, Olena; Kimble, Roy M

    2010-12-01

    This study describes the ultrasound assessment of burn scars in paediatric patients and the association of these scar thickness with laser Doppler imaging (LDI) determined burn depth. A total of 60 ultrasound scar assessments were conducted on 33 scars from 21 paediatric burn patients at 3, 6 and 9 months after-burn. The mean of peak scar thickness was 0.39±0.032 cm, with the thickest at 6 months (0.40±0.036 cm). There were 17 scald burn scars (0.34±0.045 cm), 4 contact burn scars (0.61±0.092 cm), and 10 flame burn scars (0.42±0.058 cm). Each group of scars followed normal distributions. Twenty-three scars had original burns successfully scanned by LDI and various depths of burns were presented by different colours according to blood perfusion units (PU), with dark blue <125, light blue 125-250, and green 250-440 PU. The thickness of these scars was significantly different between the predominant colours of burns, with the thinnest scars for green coloured burns and the thickest for dark blue coloured burns. Within light blue burns, grafted burns healed with significantly thinner scars than non-grafted burns. This study indicates that LDI can be used for predicting the risk of hypertrophic scarring and for guiding burn care. To our knowledge, this is the first study to correlate the thickness of burns scars by ultrasound scan with burn depth determined by LDI.

  6. Different imaging methods in the comparative assessment of vascular lesions: color-coded duplex sonography, laser Doppler perfusion imaging, and infrared thermography

    NASA Astrophysics Data System (ADS)

    Urban, Peter; Philipp, Carsten M.; Weinberg, Lutz; Berlien, Hans-Peter

    1997-12-01

    Aim of the study was the comparative investigation of cutaneous and subcutaneous vascular lesions. By means of color coded duplex sonography (CCDS), laser doppler perfusion imaging (LDPI) and infrared thermography (IT) we examined hemangiomas, vascular malformations and portwine stains to get some evidence about depth, perfusion and vascularity. LDI is a helpful method to get an impression of the capillary part of vascular lesions and the course of superficial vessels. CCDS has disadvantages in the superficial perfusion's detection but connections to deeper vascularizations can be examined precisely, in some cases it is the only method for visualizing vascular malformations. IT gives additive hints on low blood flow areas or indicates arterial-venous-shunts. Only the combination of all imaging methods allows a complete assessment, not only for planning but also for controlling the laser treatment of vascular lesions.

  7. Composite NDE using full-field pulse-echo ultrasonic propagation imaging system

    NASA Astrophysics Data System (ADS)

    Hong, Seung-Chan; Lee, Jung-Ryul; Park, Jongwoon

    2016-04-01

    In this paper, a novel ultrasonic propagation imaging system, called a full-field pulse-echo ultrasonic propagation imaging (FF PE UPI) system is presented. The coincided laser beams for ultrasonic sensing and generation are scanned and pulse-echo mode laser ultrasounds are captured. This procedure makes it possible to generate full-field ultrasound in through-the-thickness direction as large as the scan area. The system nondestructively inspected targets with two-axis translation stages. Various structural inspection results in the form of full-field ultrasonic wave propagation videos are introduced, which are an aluminum honeycomb sandwich, ailerons and carbon fiber reinforced plastic (CFRP) honeycomb sandwich structures including various defects.

  8. Fingerprint imaging from the inside of a finger with full-field optical coherence tomography

    PubMed Central

    Auksorius, Egidijus; Boccara, A. Claude

    2015-01-01

    Imaging below fingertip surface might be a useful alternative to the traditional fingerprint sensing since the internal finger features are more reliable than the external ones. One of the most promising subsurface imaging technique is optical coherence tomography (OCT), which, however, has to acquire 3-D data even when a single en face image is required. This makes OCT inherently slow for en face imaging and produce unnecessary large data sets. Here we demonstrate that full-field optical coherence tomography (FF-OCT) can be used to produce en face images of sweat pores and internal fingerprints, which can be used for the identification purposes. PMID:26601009

  9. Laser Doppler velocimetry primer

    NASA Technical Reports Server (NTRS)

    Bachalo, William D.

    1985-01-01

    Advanced research in experimental fluid dynamics required a familiarity with sophisticated measurement techniques. In some cases, the development and application of new techniques is required for difficult measurements. Optical methods and in particular, the laser Doppler velocimeter (LDV) are now recognized as the most reliable means for performing measurements in complex turbulent flows. And such, the experimental fluid dynamicist should be familiar with the principles of operation of the method and the details associated with its application. Thus, the goals of this primer are to efficiently transmit the basic concepts of the LDV method to potential users and to provide references that describe the specific areas in greater detail.

  10. Imaging of transient surface acoustic waves by full-field photorefractive interferometry

    SciTech Connect

    Xiong, Jichuan; Xu, Xiaodong E-mail: christ.glorieux@fys.kuleuven.be; Glorieux, Christ E-mail: christ.glorieux@fys.kuleuven.be; Matsuda, Osamu; Cheng, Liping

    2015-05-15

    A stroboscopic full-field imaging technique based on photorefractive interferometry for the visualization of rapidly changing surface displacement fields by using of a standard charge-coupled device (CCD) camera is presented. The photorefractive buildup of the space charge field during and after probe laser pulses is simulated numerically. The resulting anisotropic diffraction upon the refractive index grating and the interference between the polarization-rotated diffracted reference beam and the transmitted signal beam are modeled theoretically. The method is experimentally demonstrated by full-field imaging of the propagation of photoacoustically generated surface acoustic waves with a temporal resolution of nanoseconds. The surface acoustic wave propagation in a 23 mm × 17 mm area on an aluminum plate was visualized with 520 × 696 pixels of the CCD sensor, yielding a spatial resolution of 33 μm. The short pulse duration (8 ns) of the probe laser yields the capability of imaging SAWs with frequencies up to 60 MHz.

  11. Transmission X-ray microscopy for full-field nano imaging of biomaterials.

    PubMed

    Andrews, Joy C; Meirer, Florian; Liu, Yijin; Mester, Zoltan; Pianetta, Piero

    2011-07-01

    Imaging of cellular structure and extended tissue in biological materials requires nanometer resolution and good sample penetration, which can be provided by current full-field transmission X-ray microscopic techniques in the soft and hard X-ray regions. The various capabilities of full-field transmission X-ray microscopy (TXM) include 3D tomography, Zernike phase contrast, quantification of absorption, and chemical identification via X-ray fluorescence and X-ray absorption near edge structure imaging. These techniques are discussed and compared in light of results from the imaging of biological materials including microorganisms, bone and mineralized tissue, and plants, with a focus on hard X-ray TXM at ≤ 40-nm resolution. PMID:20734414

  12. Transmission X-ray microscopy for full-field nano-imaging of biomaterials

    PubMed Central

    ANDREWS, JOY C; MEIRER, FLORIAN; LIU, YIJIN; MESTER, ZOLTAN; PIANETTA, PIERO

    2010-01-01

    Imaging of cellular structure and extended tissue in biological materials requires nanometer resolution and good sample penetration, which can be provided by current full-field transmission X-ray microscopic techniques in the soft and hard X-ray regions. The various capabilities of full-field transmission X-ray microscopy (TXM) include 3D tomography, Zernike phase contrast, quantification of absorption, and chemical identification via X-ray fluorescence and X-ray absorption near edge structure (XANES) imaging. These techniques are discussed and compared in light of results from imaging of biological materials including microorganisms, bone and mineralized tissue and plants, with a focus on hard X-ray TXM at ≤ 40 nm resolution. PMID:20734414

  13. FXI: a full-field imaging beamline at NSLS-II

    NASA Astrophysics Data System (ADS)

    Lee, Wah-Keat; Reininger, Ruben; Loo, William; Gambella, Richard; O'Hara, Steven; Chu, Yong S.; Zhong, Zhong; Wang, Jun

    2015-09-01

    The Full-field X-ray Imaging (FXI) beamline at the NSLS-II is designed for optimum performance of a transmission x-ray microscope (TXM). When complete, FXI will enable the TXM to obtain individual 2D projection images at 30 nm spatial resolution and up to 40 microns field of view (FOV) with exposure times of < 50 ms per image. A complete 3D nanotomography data set should take less than 1 minute. This will open opportunities for many real-time in-operando studies.

  14. High-resolution imaging of biological tissue with full-field optical coherence tomography

    NASA Astrophysics Data System (ADS)

    Zhu, Yue; Gao, Wanrong

    2015-03-01

    A new full-field optical coherence tomography system with high-resolution has been developed for imaging of cells and tissues. Compared with other FF-OCT (Full-field optical coherence tomography, FF-OCT) systems illuminated with optical fiber bundle, the improved Köhler illumination arrangement with a halogen lamp was used in the proposed FF-OCT system. High numerical aperture microscopic objectives were used for imaging and a piezoelectric ceramic transducer (PZT) was used for phase-shifting. En-face tomographic images can be obtained by applying the five-step phase-shifting algorithm to a series of interferometric images which are recorded by a smart camera. Three-dimensional images can be generated from these tomographic images. Imaging of the chip of Intel Pentium 4 processor demonstrated the ultrahigh resolution of the system (lateral resolution is 0.8μm ), which approaches the theoretical resolution 0.7 μm× 0.5 μm (lateral × axial). En-face images of cells of onion show an excellent performance of the system in generating en-face images of biological tissues. Then, unstained pig stomach was imaged as a tissue and gastric pits could be easily recognized using FF-OCT system. Our study provides evidence for the potential ability of FFOCT in identifying gastric pits from pig stomach tissue. Finally, label-free and unstained ex vivo human liver tissues from both normal and tumor were imaged with this FFOCT system. The results show that the setup has the potential for medical diagnosis applications such liver cancer diagnosis.

  15. [Full-field and automatic methodology of spectral calibration for PGP imaging spectrometer].

    PubMed

    Sun, Ci; Bayanheshig; Cui, Ji-cheng; Pan, Ming-zhong; Li, Xiao-tian; Tang, Yu-guo

    2014-08-01

    In order to analyze spectral data quantitatively which is obtained by prism-grating-prism imaging spectrometer, spectral calibration is required in order to determine spectral characteristics of PGP imaging spectrometer, such as the center wavelength of every spectral channel, spectral resolution and spectral bending. A spectral calibration system of full field based on collimated monochromatic light method is designed. Spherical mirror is used to provide collimated light, and a freely sliding and rotating folding mirror is adopted to change the angle of incident light in order to realize full field and automatic calibration of imaging spectrometer. Experiments of spectral calibration have been done for PGP imaging spectrometer to obtain parameters of spectral performance, and accuracy analysis combined with the structural features of the entire spectral calibration system have been done. Analysis results indicate that spectral calibration accuracy of the calibration system reaches 0.1 nm, and the bandwidth accuracy reaches 1.3%. The calibration system has merits of small size, better commonality, high precision and so on, and because of adopting the control of automation, the additional errors which are caused by human are avoided. The calibration system can be used for spectral calibration of other imaging spectrometers whose structures are similar to PGP.

  16. Time domain algorithm for accelerated determination of the first order moment of photo current fluctuations in high speed laser Doppler perfusion imaging.

    PubMed

    Draijer, Matthijs; Hondebrink, Erwin; van Leeuwen, Ton; Steenbergen, Wiendelt

    2009-10-01

    Advances in optical array sensor technology allow for the real time acquisition of dynamic laser speckle patterns generated by tissue perfusion, which, in principle,allows for real time laser Doppler perfusion imaging(LDPI). Exploitation of these developments is enhanced with the introduction of faster algorithms to transform photo currents into perfusion estimates using the first moment of the power spectrum. A time domain (TD)algorithm is presented for determining the first-order spectral moment. Experiments are performed to compare this algorithm with the widely used Fast Fourier Transform(FFT). This study shows that the TD-algorithm is twice as fast as the FFT-algorithm without loss of accuracy.Compared to FFT, the TD-algorithm is efficient in terms of processor time, memory usage and data transport. PMID:19820976

  17. Development of achromatic full-field hard x-ray microscopy with two monolithic imaging mirrors

    NASA Astrophysics Data System (ADS)

    Matsuyama, S.; Kino, H.; Yasuda, S.; Kohmura, Y.; Okada, H.; Ishikawa, T.; Yamauchi, K.

    2015-09-01

    Advanced Kirkpatrick-Baez mirror optics using two monolithic imaging mirrors was developed to realize an achromatic, high-resolution, and a high-stability full-field X-ray microscope. The mirror consists of an elliptical section and a hyperbolic section on a quartz glass substrate, in which the geometry follows the Wolter (type I) optics rules. A preliminary test was performed at SPring-8 using X-rays monochromatized to 9.881 keV. A 100-nm feature on a Siemens star chart could be clearly observed.

  18. Frequency response functions of shape features from full-field vibration measurements using digital image correlation

    NASA Astrophysics Data System (ADS)

    Wang, Weizhuo; Mottershead, John E.; Siebert, Thorsten; Pipino, Andrea

    2012-04-01

    The availability of high speed digital cameras has enabled three-dimensional (3D) vibration measurement by stereography and digital image correlation (DIC). The 3D DIC technique provides non-contact full-field measurements on complex surfaces whereas conventional modal testing methods employ point-wise frequency response functions. It is proposed to identify the modal properties by utilising the domain-wise responses captured by a DIC system. This idea will be illustrated by a case study in the form a car bonnet of 3D irregular shape typical of many engineering structures. The full-field measured data are highly redundant, but the application of image processing using functional transformation enables the extraction of a small number of shape features without any significant loss of information from the raw DIC data. The complex bonnet surface on which the displacement responses are measured is essentially a 2-manifold. It is possible to apply surface parameterisation to 'flatten' the 3D surface to form a 2D planar domain. Well-developed image processing techniques are defined on planar domains and used to extract features from the displacement patterns on the surface of a specimen. An adaptive geometric moment descriptor (AGMD), defined on surface parametric space, is able to extract shape features from a series of full-field transient responses under random excitation. Results show the effectiveness of the AGMD and the obtained shape features are demonstrated to be succinct and efficient. Approximately 14 thousand data points of raw DIC measurement are represented by 20 shape feature terms at each time step. Shape-descriptor frequency response functions (SD-FRFs) of the response field and the loading field are derived in the shape feature space. It is seen that the SD-FRF has a similar format to the conventional receptance FRF. The usual modal identification procedure is applied to determine the natural frequencies, damping factors and eigen-shape-feature vectors

  19. Low spatial coherence electrically pumped semiconductor laser for speckle-free full-field imaging

    PubMed Central

    Redding, Brandon; Cerjan, Alexander; Huang, Xue; Lee, Minjoo Larry; Stone, A. Douglas; Choma, Michael A.; Cao, Hui

    2015-01-01

    The spatial coherence of laser sources has limited their application to parallel imaging and projection due to coherent artifacts, such as speckle. In contrast, traditional incoherent light sources, such as thermal sources or light emitting diodes (LEDs), provide relatively low power per independent spatial mode. Here, we present a chip-scale, electrically pumped semiconductor laser based on a novel design, demonstrating high power per mode with much lower spatial coherence than conventional laser sources. The laser resonator was fabricated with a chaotic, D-shaped cavity optimized to achieve highly multimode lasing. Lasing occurs simultaneously and independently in ∼1,000 modes, and hence the total emission exhibits very low spatial coherence. Speckle-free full-field imaging is demonstrated using the chaotic cavity laser as the illumination source. The power per mode of the sample illumination is several orders of magnitude higher than that of a LED or thermal light source. Such a compact, low-cost source, which combines the low spatial coherence of a LED with the high spectral radiance of a laser, could enable a wide range of high-speed, full-field imaging and projection applications. PMID:25605946

  20. Low spatial coherence electrically pumped semiconductor laser for speckle-free full-field imaging.

    PubMed

    Redding, Brandon; Cerjan, Alexander; Huang, Xue; Lee, Minjoo Larry; Stone, A Douglas; Choma, Michael A; Cao, Hui

    2015-02-01

    The spatial coherence of laser sources has limited their application to parallel imaging and projection due to coherent artifacts, such as speckle. In contrast, traditional incoherent light sources, such as thermal sources or light emitting diodes (LEDs), provide relatively low power per independent spatial mode. Here, we present a chip-scale, electrically pumped semiconductor laser based on a novel design, demonstrating high power per mode with much lower spatial coherence than conventional laser sources. The laser resonator was fabricated with a chaotic, D-shaped cavity optimized to achieve highly multimode lasing. Lasing occurs simultaneously and independently in ∼1,000 modes, and hence the total emission exhibits very low spatial coherence. Speckle-free full-field imaging is demonstrated using the chaotic cavity laser as the illumination source. The power per mode of the sample illumination is several orders of magnitude higher than that of a LED or thermal light source. Such a compact, low-cost source, which combines the low spatial coherence of a LED with the high spectral radiance of a laser, could enable a wide range of high-speed, full-field imaging and projection applications. PMID:25605946

  1. Imaging of transient surface acoustic waves by full-field photorefractive interferometry.

    PubMed

    Xiong, Jichuan; Xu, Xiaodong; Glorieux, Christ; Matsuda, Osamu; Cheng, Liping

    2015-05-01

    A stroboscopic full-field imaging technique based on photorefractive interferometry for the visualization of rapidly changing surface displacement fields by using of a standard charge-coupled device (CCD) camera is presented. The photorefractive buildup of the space charge field during and after probe laser pulses is simulated numerically. The resulting anisotropic diffraction upon the refractive index grating and the interference between the polarization-rotated diffracted reference beam and the transmitted signal beam are modeled theoretically. The method is experimentally demonstrated by full-field imaging of the propagation of photoacoustically generated surface acoustic waves with a temporal resolution of nanoseconds. The surface acoustic wave propagation in a 23 mm × 17 mm area on an aluminum plate was visualized with 520 × 696 pixels of the CCD sensor, yielding a spatial resolution of 33 μm. The short pulse duration (8 ns) of the probe laser yields the capability of imaging SAWs with frequencies up to 60 MHz. PMID:26026514

  2. Numerical correction of distorted images in full-field optical coherence tomography

    NASA Astrophysics Data System (ADS)

    Min, Gihyeon; Kim, Ju Wan; Choi, Woo June; Lee, Byeong Ha

    2012-03-01

    We propose a numerical method which can numerically correct the distorted en face images obtained with a full field optical coherence tomography (FF-OCT) system. It is shown that the FF-OCT image of the deep region of a biological sample is easily blurred or degraded because the sample has a refractive index (RI) much higher than its surrounding medium in general. It is analyzed that the focal plane of the imaging system is segregated from the imaging plane of the coherence-gated system due to the RI mismatch. This image-blurring phenomenon is experimentally confirmed by imaging the chrome pattern of a resolution test target through its glass substrate in water. Moreover, we demonstrate that the blurred image can be appreciably corrected by using the numerical correction process based on the Fresnel-Kirchhoff diffraction theory. The proposed correction method is applied to enhance the image of a human hair, which permits the distinct identification of the melanin granules inside the cortex layer of the hair shaft.

  3. Full-field velocity imaging of red blood cells in capillaries with spatiotemporal demodulation autocorrelation

    NASA Astrophysics Data System (ADS)

    Wang, Mingyi; Zeng, Yaguang; Dong, Nannan; Liao, Riwei; Yang, Guojian

    2016-03-01

    We propose a full-field optical method for the label-free and quantitative mapping of the velocities of red blood cells (RBCs) in capillaries. It integrates spatiotemporal demodulation and an autocorrelation algorithm, and measures RBC velocity according to the ratio of RBC length to lag time. Conventionally, RBC length is assumed to be a constant and lag time is taken as a variable, while our method treats both of them as variables. We use temporal demodulation and the Butterworth spatial filter to separate RBC signal from background signal, based on which we obtain the RBC length by image segmentation and lag time by autocorrelation analysis. The RBC velocity calculated now is more accurate. The validity of our method is verified by an in vivo experiment on a mouse ear. Owing to its higher image signal-to-noise ratio, our method can be used for mapping RBC velocity in the turbid tissue case.

  4. Image restoration method based on Hilbert transform for full-field optical coherence tomography

    NASA Astrophysics Data System (ADS)

    Na, Jihoon; Choi, Woo June; Choi, Eun Seo; Ryu, Seon Young; Lee, Byeong Ha

    2008-01-01

    A full-field optical coherence tomography (FF-OCT) system utilizing a simple but novel image restoration method suitable for a high-speed system is demonstrated. An en-face image is retrieved from only two phase-shifted interference fringe images through using the mathematical Hilbert transform. With a thermal light source, a high-resolution FF-OCT system having axial and transverse resolutions of 1 and 2.2 μm, respectively, was implemented. The feasibility of the proposed scheme is confirmed by presenting the obtained en-face images of biological samples such as a piece of garlic and a gold beetle. The proposed method is robust to the error in the amount of the phase shift and does not leave residual fringes. The use of just two interference images and the strong immunity to phase errors provide great advantages in the imaging speed and the system design flexibility of a high-speed high-resolution FF-OCT system.

  5. High-resolution full-field optical coherence tomography using high dynamic range image processing

    NASA Astrophysics Data System (ADS)

    Leong-Hoï, A.; Claveau, R.; Montgomery, P. C.; Serio, B.; Uhring, W.; Anstotz, F.; Flury, M.

    2016-04-01

    Full-field optical coherence tomography (FF-OCT) based on white-light interference microscopy, is an emerging noninvasive imaging technique for characterizing biological tissue or optical scattering media with micrometer resolution. Tomographic images can be obtained by analyzing a sequence of interferograms acquired with a camera. This is achieved by scanning an interferometric microscope objectives along the optical axis and performing appropriate signal processing for fringe envelope extraction, leading to three-dimensional imaging over depth. However, noise contained in the images can hide some important details or induce errors in the size of these details. To firstly reduce temporal and spatial noise from the camera, it is possible to apply basic image post processing methods such as image averaging, dark frame subtraction or flat field division. It has been demonstrate that this can improve the quality of microscopy images by enhancing the signal to noise ratio. In addition, the dynamic range of images can be enhanced to improve the contrast by combining images acquired with different exposure times or light intensity. This can be made possible by applying a hybrid high dynamic range (HDR) technique, which is proposed in this paper. High resolution tomographic analysis is thus performed using a combination of the above-mentioned image processing techniques. As a result, the lateral resolution of the system can be improved so as to approach the diffraction limit of the microscope as well as to increase the power of detection, thus enabling new sub-diffraction sized structures contained in a transparent layer, initially hidden by the noise, to be detected.

  6. Laser Doppler velocimeter measurements and laser sheet imaging in an annular combustor model. M.S. Thesis, Final Report

    NASA Technical Reports Server (NTRS)

    Dwenger, Richard Dale

    1995-01-01

    An experimental study was conducted in annular combustor model to provide a better understanding of the flowfield. Combustor model configurations consisting of primary jets only, annular jets only, and a combination of annular and primary jets were investigated. The purpose of this research was to provide a better understanding of combustor flows and to provide a data base for comparison with computational models. The first part of this research used a laser Doppler velocimeter to measure mean velocity and statistically calculate root-mean-square velocity in two coordinate directions. From this data, one Reynolds shear stress component and a two-dimensional turbulent kinetic energy term was determined. Major features of the flowfield included recirculating flow, primary and annular jet interaction, and high turbulence. The most pronounced result from this data was the effect the primary jets had on the flowfield. The primary jets were seen to reduce flow asymmetries, create larger recirculation zones, and higher turbulence levels. The second part of this research used a technique called marker nephelometry to provide mean concentration values in the combustor. Results showed the flow to be very turbulent and unsteady. All configurations investigated were highly sensitive to alignment of the primary and annular jets in the model and inlet conditions. Any imbalance between primary jets or misalignment of the annular jets caused severe flow asymmetries.

  7. High resolution in-vivo imaging of skin with full field optical coherence tomography

    NASA Astrophysics Data System (ADS)

    Dalimier, E.; Bruhat, Alexis; Grieve, K.; Harms, F.; Martins, F.; Boccara, C.

    2014-03-01

    Full-field OCT (FFOCT) has the ability to provide en-face images with a very good axial sectioning as well as a very high transverse resolution (about 1 microns in all directions). Therefore it offers the possibility to visualize biological tissues with very high resolution both on the axial native view, and on vertical reconstructed sections. Here we investigated the potential dermatological applications of in-vivo skin imaging with FFOCT. A commercial FFOCT device was adapted for the in-vivo acquisition of stacks of images on the arm, hand and finger. Several subjects of different benign and pathological skin conditions were tested. The images allowed measurement of the stratum corneum and epidermis thicknesses, measurement of the stratum corneum refractive index, size measurement and count of the keratinocytes, visualization of the dermal-epidermal junction, and visualization of the melanin granules and of the melanocytes. Skins with different pigmentations could be discriminated and skin pathologies such as eczema could be identified. The very high resolution offered by FFOCT both on axial native images and vertical reconstructed sections allows for the visualization and measurement of a set of parameters useful for cosmetology and dermatology. In particular, FFOCT is a potential tool for the understanding and monitoring of skin hydration and pigmentation, as well as skin inflammation.

  8. Full-Field Imaging of GHz Film Bulk Acoustic Resonator Motion

    SciTech Connect

    Telschow, Kenneth Louis; Deason, Vance Albert; Cottle, David Lynn; Larson III, J. D.

    2003-10-01

    A full-field view laser ultrasonic imaging method has been developed that measures acoustic motion at a surface without scanning. Images are recorded at normal video frame rates by using dynamic holography with photorefractive interferometric detection. By extending the approach to ultra high frequencies, an acoustic microscope has been developed that is capable of operation at gigahertz frequency and micron length scales. Both acoustic amplitude and phase are recorded, allowing full calibration and determination of phases to within a single arbitrary constant. Results are presented of measurements at frequencies of 800-900 MHz, illustrating a multitude of normal mode behavior in electrically driven thin film acoustic resonators. Coupled with microwave electrical impedance measurements, this imaging mode provides an exceptionally fast method for evaluation of electric-to-acoustic coupling of these devices and their performance. Images of 256 /spl times/ 240 pixels are recorded at 18 fps rates synchronized to obtain both in-phase and quadrature detection of the acoustic motion. Simple averaging provides sensitivity to the subnanometer level at each pixel calibrated over the image using interferometry. Identification of specific acoustic modes and their relationship to electrical impedance characteristics show the advantages and overall high speed of the technique.

  9. Actinic imaging of native and programmed defects on a full-field mask

    SciTech Connect

    Mochi, I.; Goldberg, K. A.; Fontaine, B. La; Tchikoulaeva, A.; Holfeld, C.

    2010-03-12

    We describe the imaging and characterization of native defects on a full field extreme ultraviolet (EUV) mask, using several reticle and wafer inspection modes. Mask defect images recorded with the SEMA TECH Berkeley Actinic Inspection Tool (AIT), an EUV-wavelength (13.4 nm) actinic microscope, are compared with mask and printed-wafer images collected with scanning electron microscopy (SEM) and deep ultraviolet (DUV) inspection tools. We observed that defects that appear to be opaque in the SEM can be highly transparent to EUV light, and inversely, defects that are mostly transparent to the SEM can be highly opaque to EUV. The nature and composition of these defects, whether they appear on the top surface, within the multilayer coating, or on the substrate as buried bumps or pits, influences both their significance when printed, and their detectability with the available techniques. Actinic inspection quantitatively predicts the characteristics of printed defect images in ways that may not be possible with non-EUV techniques. As a quantitative example, we investigate the main structural characteristics of a buried pit defect based on EUV through-focus imaging.

  10. Full-Field Imaging of Acoustic Motion at Nanosecond Time and Micron Length Scales

    SciTech Connect

    Telschow, Kenneth Louis; Deason, Vance Albert; Cottle, David Lynn; Larson III, John D.

    2002-10-01

    A full-field view laser ultrasonic imaging method has been developed that measures acoustic motion at a surface without scanning. Images are recorded at normal video frame rates by employing dynamic holography using photorefractive interferometric detection. By extending the approach to ultra high frequencies, an acoustic microscope has been developed capable of operation on the nanosecond time and micron length scales. Both acoustic amplitude and phase are recorded allowing full calibration and determination of phases to within a single arbitrary constant. Results are presented of measurements at frequencies at 800-900 MHz illustrating a multitude of normal mode behavior in electrically driven thin film acoustic resonators. Coupled with microwave electrical impedance measurements, this imaging mode provides an exceptionally fast method for evaluation of electric to acoustic coupling and performance of these devices. Images of 256x240 pixels are recorded at 18Hz rates synchronized to obtain both in-phase and quadrature detection of the acoustic motion. Simple averaging provides sensitivity to the subnanometer level calibrated over the image using interferometry. Identification of specific acoustic modes and their relationship to electrical impedance characteristics show the advantages and overall high speed of the technique.

  11. Robust full-field measurement considering rotation using digital image correlation

    NASA Astrophysics Data System (ADS)

    Wu, Rong; Qian, Hao; Zhang, Dongsheng

    2016-10-01

    Digital image correlation (DIC) has been widely accepted as a method for displacement and strain measurement and is applied in a variety of engineering fields. Most DIC algorithms encounter errors in measuring the deformation in conditions that involve rotation since they are designed without considering rotation of the deformed object. In this paper, a robust and automated DIC method capable of determining full-field displacement and strain components with random rotations has been presented. The algorithm starts with the determination of the initial position of the seed point in the integer-pixel domain. An approximate rotational angle between the reference and the deformed subset is estimated using an automated feature matching technology. A two-step Newton-Raphson algorithm has been developed for optimizing a suite of variables including displacement, strain and the rotational angle to achieve subpixel accuracy. A reliable propagation scheme, which enables rapid determination of the initial guess for full-field analysis is also proposed. Results from numerical simulations are used to validate the feasibility of the proposed DIC method. An application to 3-point bending with large deflection shows that the algorithm can be employed to measure displacement or strain parameters of the deformed object with arbitrary angles of rotation.

  12. Digital image correlation for full-field time-resolved assessment of arterial stiffness

    NASA Astrophysics Data System (ADS)

    Campo, Adriaan; Soons, Joris; Heuten, Hilde; Ennekens, Guy; Goovaerts, Inge; Vrints, Christiaan; Lava, Pascal; Dirckx, Joris

    2014-01-01

    Pulse wave velocity (PWV) of the arterial system is a very important parameter to evaluate cardiovascular health. Currently, however, there is no golden standard for PWV measurement. Digital image correlation (DIC) was used for full-field time-resolved assessment of displacement, velocity, acceleration, and strains of the skin in the neck directly above the common carotid artery. By assessing these parameters, propagation of the pulse wave could be tracked, leading to a new method for PWV detection based on DIC. The method was tested on five healthy subjects. As a means of validation, PWV was measured with ultrasound (US) as well. Measured PWV values were between 3.68 and 5.19 m/s as measured with DIC and between 5.14 and 6.58 m/s as measured with US, with a maximum absolute difference of 2.78 m/s between the two methods. DIC measurements of the neck region can serve as a test base for determining a robust strategy for PWV detection, they can serve as reference for three-dimensional fluid-structure interaction models, or they may even evolve into a screening method of their own. Moreover, full-field, time-resolved DIC can be adapted for other applications in biomechanics.

  13. A comparison of image interpretation times in full field digital mammography and digital breast tomosynthesis

    NASA Astrophysics Data System (ADS)

    Astley, Susan; Connor, Sophie; Lim, Yit; Tate, Catriona; Entwistle, Helen; Morris, Julie; Whiteside, Sigrid; Sergeant, Jamie; Wilson, Mary; Beetles, Ursula; Boggis, Caroline; Gilbert, Fiona

    2013-03-01

    Digital Breast Tomosynthesis (DBT) provides three-dimensional images of the breast that enable radiologists to discern whether densities are due to overlapping structures or lesions. To aid assessment of the cost-effectiveness of DBT for screening, we have compared the time taken to interpret DBT images and the corresponding two-dimensional Full Field Digital Mammography (FFDM) images. Four Consultant Radiologists experienced in reading FFDM images (4 years 8 months to 8 years) with training in DBT interpretation but more limited experience (137-407 cases in the past 6 months) were timed reading between 24 and 32 two view FFDM and DBT cases. The images were of women recalled from screening for further assessment and women under surveillance because of a family history of breast cancer. FFDM images were read before DBT, according to local practice. The median time for readers to interpret FFDM images was 17.0 seconds, with an interquartile range of 12.3-23.6 seconds. For DBT, the median time was 66.0 seconds, and the interquartile range was 51.1-80.5 seconds. The difference was statistically significant (p<0.001). Reading times were significantly longer in family history clinics (p<0.01). Although it took approximately four times as long to interpret DBT than FFDM images, the cases were more complex than would be expected for routine screening, and with higher mammographic density. The readers were relatively inexperienced in DBT interpretation and may increase their speed over time. The difference in times between clinics may be due to increased throughput at assessment, or decreased density.

  14. Localization-based full-field microscopy: how to attain super-resolved images

    PubMed Central

    Son, Taehwang; Lee, Wonju; Kim, Donghyun

    2015-01-01

    In this study, we have investigated localization-based microscopy to achieve full-field super-resolution. For localized sampling, we have considered combs consisting of unit pulses and near-fields localized by surface nanoapertures. Achievable images after reconstruction were assessed in terms of peak signal-to-noise ratio (PSNR). It was found that spatial switching of individual pulses may be needed to break the diffraction limit. Among the parameters, the resolution was largely determined by sampling period while the effect of width of a sampling pulse on PSNR was relatively limited. For the range of sampling parameters that we considered, the highest resolution achievable is estimated to be 70 nm, which can further be enhanced by optimizing the localization parameters. PMID:26201451

  15. From supersonic shear wave imaging to full-field optical coherence shear wave elastography

    NASA Astrophysics Data System (ADS)

    Nahas, Amir; Tanter, Mickaël; Nguyen, Thu-Mai; Chassot, Jean-Marie; Fink, Mathias; Claude Boccara, A.

    2013-12-01

    Elasticity maps of tissue have proved to be particularly useful in providing complementary contrast to ultrasonic imaging, e.g., for cancer diagnosis at the millimeter scale. Optical coherence tomography (OCT) offers an endogenous contrast based on singly backscattered optical waves. Adding complementary contrast to OCT images by recording elasticity maps could also be valuable in improving OCT-based diagnosis at the microscopic scale. Static elastography has been successfully coupled with full-field OCT (FF-OCT) in order to realize both micrometer-scale sectioning and elasticity maps. Nevertheless, static elastography presents a number of drawbacks, mainly when stiffness quantification is required. Here, we describe the combination of two methods: transient elastography, based on speed measurements of shear waves induced by ultrasonic radiation forces, and FF-OCT, an en face OCT approach using an incoherent light source. The use of an ultrafast ultrasonic scanner and an ultrafast camera working at 10,000 to 30,000 images/s made it possible to follow shear wave propagation with both modalities. As expected, FF-OCT is found to be much more sensitive than ultrafast ultrasound to tiny shear vibrations (a few nanometers and micrometers, respectively). Stiffness assessed in gel phantoms and an ex vivo rat brain by FF-OCT is found to be in good agreement with ultrasound shear wave elastography.

  16. Hard X-ray Full Field Nano-imaging of Bone and Nanowires at SSRL

    SciTech Connect

    Andrews, Joy C.; Pianetta, Piero; Meirer, Florian; Chen Jie; Almeida, Eduardo; Meulen, Marjolein C. H. van der; Alwood, Joshua S.; Lee, Cathy; Zhu Jia; Cui Yi

    2010-06-23

    A hard X-ray full field microscope from Xradia Inc. has been installed at SSRL on a 54-pole wiggler end station at beam line 6-2. It has been optimized to operate from 5-14 keV with resolution as high as 30 nm. High quality images are achieved using a vertical beam stabilizer and condenser scanner with high efficiency zone plates with 30 nm outermost zone width. The microscope has been used in Zernike phase contrast, available at 5.4 keV and 8 keV, as well as absorption contrast to image a variety of biological, environmental and materials samples. Calibration of the X-ray attenuation with crystalline apatite enabled quantification of bone density of plate-like and rod-like regions of mouse bone trabecula. 3D tomography of individual lacuna revealed the surrounding cell canaliculi and processes. 3D tomography of chiral branched PbSe nanowires showed orthogonal branches around a central nanowire.

  17. Full Field X-Ray Fluorescence Imaging Using Micro Pore Optics for Planetary Surface Exploration

    NASA Technical Reports Server (NTRS)

    Sarrazin, P.; Blake, D. F.; Gailhanou, M.; Walter, P.; Schyns, E.; Marchis, F.; Thompson, K.; Bristow, T.

    2016-01-01

    Many planetary surface processes leave evidence as small features in the sub-millimetre scale. Current planetary X-ray fluorescence spectrometers lack the spatial resolution to analyse such small features as they only provide global analyses of areas greater than 100 mm(exp 2). A micro-XRF spectrometer will be deployed on the NASA Mars 2020 rover to analyse spots as small as 120m. When using its line-scanning capacity combined to perpendicular scanning by the rover arm, elemental maps can be generated. We present a new instrument that provides full-field XRF imaging, alleviating the need for precise positioning and scanning mechanisms. The Mapping X-ray Fluorescence Spectrometer - "Map-X" - will allow elemental imaging with approximately 100µm spatial resolution and simultaneously provide elemental chemistry at the scale where many relict physical, chemical and biological features can be imaged in ancient rocks. The arm-mounted Map-X instrument is placed directly on the surface of an object and held in a fixed position during measurements. A 25x25 mm(exp 2) surface area is uniformly illuminated with X-rays or alpha-particles and gamma-rays. A novel Micro Pore Optic focusses a fraction of the emitted X-ray fluorescence onto a CCD operated at a few frames per second. On board processing allows measuring the energy and coordinates of each X-ray photon collected. Large sets of frames are reduced into 2d histograms used to compute higher level data products such as elemental maps and XRF spectra from selected regions of interest. XRF spectra are processed on the ground to further determine quantitative elemental compositions. The instrument development will be presented with an emphasis on the characterization and modelling of the X-ray focussing Micro Pore Optic. An outlook on possible alternative XRF imaging applications will be discussed.

  18. A comparison between objective and subjective image quality measurements for a full field digital mammography system.

    PubMed

    Marshall, N W

    2006-05-21

    This paper presents pre-sampling modulation transfer function (MTF), normalized noise power spectrum (NNPS) and detective quantum efficiency (DQE) results for an amorphous selenium (a-Se) full field digital mammography system. MTF was calculated from the image of an angled 0.5 mm thick Cu edge, acquired without additional beam filtration. NNPS data were acquired at detector air-kerma levels ranging from 9.1 microGy to 331 microGy, using a standard mammography x-ray spectrum of 28 kV, Mo/Mo target/filter combination and 4 cm of PMMA additional filtration. Prior to NNPS estimation, the image statistics were assessed using a variance image. This method was able to easily identify a detector artefact and should prove useful in routine quality assurance (QA) measurements. Detector DQE, calculated from the NNPS and MTF data, dropped to 0.3 for low detector air-kerma settings but reached an approximately constant value of 0.6 above 50 microGy at the detector. Subjective image quality data were also obtained at these detector air-kerma settings using the CDMAM contrast-detail (c-d) test object. The c-d data reflected the trend seen in DQE, with threshold contrast increasing at low detector air-kerma values. The c-d data were then compared against predictions made using two established models, the Rose model and a standard signal detection theory model. Using DQE(0), the Rose model gave results within approximately 15% on average for all the detector air-kerma values studied and for detail diameters down to 0.2 mm. Similar agreement was also found between the measured c-d data and the signal detection theory results, which were calculated using an ideal human visual response function and a system magnification of unity. The use of full spatial frequency DQE improved the agreement between the calculated and observer results for detail sizes below 0.13 mm.

  19. Widefield laser doppler velocimeter: development and theory.

    SciTech Connect

    Hansche, Bruce David; Reu, Phillip L.; Massad, Jordan Elias

    2007-03-01

    The widefield laser Doppler velocimeter is a new measurement technique that significantly expands the functionality of a traditional scanning system. This new technique allows full-field velocity measurements without scanning, a drawback of traditional measurement techniques. This is particularly important for tests in which the sample is destroyed or the motion of the sample is non-repetitive. The goal of creating ''velocity movies'' was accomplished during the research, and this report describes the current functionality and operation of the system. The mathematical underpinnings and system setup are thoroughly described. Two prototype experiments are then presented to show the practical use of the current system. Details of the corresponding hardware used to collect the data and the associated software to analyze the data are presented.

  20. Analysis of laser speckle contrast images variability using a novel empirical mode decomposition: comparison of results with laser Doppler flowmetry signals variability.

    PubMed

    Humeau-Heurtier, Anne; Abraham, Pierre; Mahe, Guillaume

    2015-02-01

    Laser Doppler flowmetry (LDF) and laser speckle contrast imaging (LSCI) have emerged as noninvasive optical modalities to monitor microvascular blood flow. Many studies proposed to extract physiological information from LDF by analyzing signals variability. By opposition, such analyses for LSCI data have not been conducted yet. We propose to analyze LSCI variability using a novel data-driven method: the complete ensemble empirical mode decomposition with adaptive noise (CEEMDAN). CEEMDAN is suitable for nonlinear and nonstationary data and leads to intrinsic mode functions (IMFs). It is based on the ensemble empirical mode decomposition (EEMD) which relies on empirical mode decomposition (EMD). In our work the average frequencies of LSCI IMFs given by CEEMDAN are compared with the ones given by EMD and EEMD. Moreover, LDF signals acquired simultaneously to LSCI data are also processed with CEEMDAN, EMD and EEMD. We show that the average frequencies of IMFs given by CEEMDAN depend on the signal-to-noise ratio (SNR) used in the computation but, for a given SNR, the average frequencies found for LSCI are close to the ones obtained for LDF. By opposition, EEMD leads to IMFs with frequencies that do not vary much when the SNR level is higher than a threshold. The new CEEMDAN algorithm has the advantage of achieving a complete decomposition with no error in the reconstruction but our study suggests that further work is needed to gain knowledge in the adjustment of the added noise level. CEEMDAN, EMD and EEMD are data-driven methods that can provide a better knowledge of LSCI.

  1. Confocal full-field X-ray microscope for novel three-dimensional X-ray imaging.

    PubMed

    Takeuchi, Akihisa; Terada, Yasuko; Suzuki, Yoshio; Uesugi, Kentaro; Aoki, Sadao

    2009-09-01

    A confocal full-field X-ray microscope has been developed for use as a novel three-dimensional X-ray imaging method. The system consists of an X-ray illuminating ;sheet-beam' whose beam shape is micrified only in one dimension, and an X-ray full-field microscope whose optical axis is normal to the illuminating sheet beam. An arbitral cross-sectional region of the object is irradiated by the sheet-beam, and secondary X-ray emission such as fluorescent X-rays from this region is imaged simultaneously using the full-field microscope. This system enables a virtual sliced image of a specimen to be obtained as a two-dimensional magnified image, and three-dimensional observation is available only by a linear translation of the object along the optical axis of the full-field microscope. A feasibility test has been carried out at beamline 37XU of SPring-8. Observation of the three-dimensional distribution of metallic inclusions in an artificial diamond was performed. PMID:19713634

  2. [Full-field OCT].

    PubMed

    Dubois, Arnaud; Boccara, Claude

    2006-10-01

    Optical coherence tomography (OCT) is an emerging technique for imaging of biological media with micrometer-scale resolution, whose most significant impact concerns ophthalmology. Since its introduction in the early 1990's, OCT has known a lot of improvements and sophistications. Full-field OCT is our original approach of OCT, based on white-light interference microscopy. Tomographic images are obtained by combination of interferometric images recorded in parallel by a detector array such as a CCD camera. Whereas conventional OCT produces B-mode (axially-oriented) images like ultrasound imaging, full-field OCT acquires tomographic images in the en face (transverse) orientation. Full-field OCT is an alternative method to conventional OCT to provide ultrahigh resolution images (approximately 1 microm), using a simple halogen lamp instead of a complex laser-based source. Various studies have been carried, demonstrating the performances of this technology for three-dimensional imaging of ex vivo specimens. Full-field OCT can be used for non-invasive histological studies without sample preparation. In vivo imaging is still difficult because of the object motions. A lot of efforts are currently devoted to overcome this limitation. Ultra-fast full-field OCT was recently demonstrated with unprecedented image acquisition speed, but the detection sensitivity has still to be improved. Other research directions include the increase of the imaging penetration depth in highly scattering biological tissues such as skin, and the exploitation of new contrasts such as optical birefringence to provide additional information on the tissue morphology and composition. PMID:17026940

  3. Relative indexes of cutaneous blood perfusion measured by real-time laser Doppler imaging (LDI) in healthy volunteers.

    PubMed

    Seyed Jafari, S Morteza; Schawkat, Megir; Van De Ville, Dimitri; Shafighi, Maziar

    2014-07-01

    We used real-time LDI to study regional variations in microcirculatory perfusion in healthy candidates to establish a new methodology for global perfusion body mapping that is based on intra-individual perfusion index ratios. Our study included 74 (37 female) healthy volunteers aged between 22 and 30 years (mean 24.49). Imaging was performed using a recent microcirculation-imaging camera (EasyLDI) for different body regions of each volunteer. The perfusion values were reported in Arbitrary Perfusion Units (APU). The relative perfusion indexes for each candidate's body region were then obtained by normalization with the perfusion value of the forehead. Basic parameters such as weight, height, and blood pressure were also measured and analyzed. The highest mean perfusion value was reported in the forehead area (259.21APU). Mean perfusion in the measured parts of the body correlated positively with mean forehead value, while there was no significant correlation between forehead blood perfusion values and room temperature, BMI, systolic blood pressure and diastolic blood pressure (p=0.420, 0.623, 0.488, 0.099, respectively). Analysis of the data showed that perfusion indexes were not significantly different between male and female volunteers except for the ventral upper arm area (p=.001). LDI is a non-invasive, fast technique that opens several avenues for clinical applications. The mean perfusion indexes are useful in clinical practice for monitoring patients before and after surgical interventions. Perfusion values can be predicted for different body parts for patients only by taking the forehead perfusion value and using the perfusion index ratios to obtain expected normative perfusion values. PMID:24788075

  4. Relative indexes of cutaneous blood perfusion measured by real-time laser Doppler imaging (LDI) in healthy volunteers.

    PubMed

    Seyed Jafari, S Morteza; Schawkat, Megir; Van De Ville, Dimitri; Shafighi, Maziar

    2014-07-01

    We used real-time LDI to study regional variations in microcirculatory perfusion in healthy candidates to establish a new methodology for global perfusion body mapping that is based on intra-individual perfusion index ratios. Our study included 74 (37 female) healthy volunteers aged between 22 and 30 years (mean 24.49). Imaging was performed using a recent microcirculation-imaging camera (EasyLDI) for different body regions of each volunteer. The perfusion values were reported in Arbitrary Perfusion Units (APU). The relative perfusion indexes for each candidate's body region were then obtained by normalization with the perfusion value of the forehead. Basic parameters such as weight, height, and blood pressure were also measured and analyzed. The highest mean perfusion value was reported in the forehead area (259.21APU). Mean perfusion in the measured parts of the body correlated positively with mean forehead value, while there was no significant correlation between forehead blood perfusion values and room temperature, BMI, systolic blood pressure and diastolic blood pressure (p=0.420, 0.623, 0.488, 0.099, respectively). Analysis of the data showed that perfusion indexes were not significantly different between male and female volunteers except for the ventral upper arm area (p=.001). LDI is a non-invasive, fast technique that opens several avenues for clinical applications. The mean perfusion indexes are useful in clinical practice for monitoring patients before and after surgical interventions. Perfusion values can be predicted for different body parts for patients only by taking the forehead perfusion value and using the perfusion index ratios to obtain expected normative perfusion values.

  5. 3D fingerprint imaging system based on full-field fringe projection profilometry

    NASA Astrophysics Data System (ADS)

    Huang, Shujun; Zhang, Zonghua; Zhao, Yan; Dai, Jie; Chen, Chao; Xu, Yongjia; Zhang, E.; Xie, Lili

    2014-01-01

    As an unique, unchangeable and easily acquired biometrics, fingerprint has been widely studied in academics and applied in many fields over the years. The traditional fingerprint recognition methods are based on the obtained 2D feature of fingerprint. However, fingerprint is a 3D biological characteristic. The mapping from 3D to 2D loses 1D information and causes nonlinear distortion of the captured fingerprint. Therefore, it is becoming more and more important to obtain 3D fingerprint information for recognition. In this paper, a novel 3D fingerprint imaging system is presented based on fringe projection technique to obtain 3D features and the corresponding color texture information. A series of color sinusoidal fringe patterns with optimum three-fringe numbers are projected onto a finger surface. From another viewpoint, the fringe patterns are deformed by the finger surface and captured by a CCD camera. 3D shape data of the finger can be obtained from the captured fringe pattern images. This paper studies the prototype of the 3D fingerprint imaging system, including principle of 3D fingerprint acquisition, hardware design of the 3D imaging system, 3D calibration of the system, and software development. Some experiments are carried out by acquiring several 3D fingerprint data. The experimental results demonstrate the feasibility of the proposed 3D fingerprint imaging system.

  6. Full field spatially-variant image-based resolution modelling reconstruction for the HRRT.

    PubMed

    Angelis, Georgios I; Kotasidis, Fotis A; Matthews, Julian C; Markiewicz, Pawel J; Lionheart, William R; Reader, Andrew J

    2015-03-01

    Accurate characterisation of the scanner's point spread function across the entire field of view (FOV) is crucial in order to account for spatially dependent factors that degrade the resolution of the reconstructed images. The HRRT users' community resolution modelling reconstruction software includes a shift-invariant resolution kernel, which leads to transaxially non-uniform resolution in the reconstructed images. Unlike previous work to date in this field, this work is the first to model the spatially variant resolution across the entire FOV of the HRRT, which is the highest resolution human brain PET scanner in the world. In this paper we developed a spatially variant image-based resolution modelling reconstruction dedicated to the HRRT, using an experimentally measured shift-variant resolution kernel. Previously, the system response was measured and characterised in detail across the entire FOV of the HRRT, using a printed point source array. The newly developed resolution modelling reconstruction was applied on measured phantom, as well as clinical data and was compared against the HRRT users' community resolution modelling reconstruction, which is currently in use. Results demonstrated improvements both in contrast and resolution recovery, particularly for regions close to the edges of the FOV, with almost uniform resolution recovery across the entire transverse FOV. In addition, because the newly measured resolution kernel is slightly broader with wider tails, compared to the deliberately conservative kernel employed in the HRRT users' community software, the reconstructed images appear to have not only improved contrast recovery (up to 20% for small regions), but also better noise characteristics.

  7. Full field spatially-variant image-based resolution modelling reconstruction for the HRRT.

    PubMed

    Angelis, Georgios I; Kotasidis, Fotis A; Matthews, Julian C; Markiewicz, Pawel J; Lionheart, William R; Reader, Andrew J

    2015-03-01

    Accurate characterisation of the scanner's point spread function across the entire field of view (FOV) is crucial in order to account for spatially dependent factors that degrade the resolution of the reconstructed images. The HRRT users' community resolution modelling reconstruction software includes a shift-invariant resolution kernel, which leads to transaxially non-uniform resolution in the reconstructed images. Unlike previous work to date in this field, this work is the first to model the spatially variant resolution across the entire FOV of the HRRT, which is the highest resolution human brain PET scanner in the world. In this paper we developed a spatially variant image-based resolution modelling reconstruction dedicated to the HRRT, using an experimentally measured shift-variant resolution kernel. Previously, the system response was measured and characterised in detail across the entire FOV of the HRRT, using a printed point source array. The newly developed resolution modelling reconstruction was applied on measured phantom, as well as clinical data and was compared against the HRRT users' community resolution modelling reconstruction, which is currently in use. Results demonstrated improvements both in contrast and resolution recovery, particularly for regions close to the edges of the FOV, with almost uniform resolution recovery across the entire transverse FOV. In addition, because the newly measured resolution kernel is slightly broader with wider tails, compared to the deliberately conservative kernel employed in the HRRT users' community software, the reconstructed images appear to have not only improved contrast recovery (up to 20% for small regions), but also better noise characteristics. PMID:25596999

  8. Improving chemical mapping algorithm and visualization in full-field hard x-ray spectroscopic imaging

    NASA Astrophysics Data System (ADS)

    Chang, Cheng; Xu, Wei; Chen-Wiegart, Yu-chen Karen; Wang, Jun; Yu, Dantong

    2013-12-01

    X-ray Absorption Near Edge Structure (XANES) imaging, an advanced absorption spectroscopy technique, at the Transmission X-ray Microscopy (TXM) Beamline X8C of NSLS enables high-resolution chemical mapping (a.k.a. chemical composition identification or chemical spectra fitting). Two-Dimensional (2D) chemical mapping has been successfully applied to study many functional materials to decide the percentages of chemical components at each pixel position of the material images. In chemical mapping, the attenuation coefficient spectrum of the material (sample) can be fitted with the weighted sum of standard spectra of individual chemical compositions, where the weights are the percentages to be calculated. In this paper, we first implemented and compared two fitting approaches: (i) a brute force enumeration method, and (ii) a constrained least square minimization algorithm proposed by us. Next, as 2D spectra fitting can be conducted pixel by pixel, so theoretically, both methods can be implemented in parallel. In order to demonstrate the feasibility of parallel computing in the chemical mapping problem and investigate how much efficiency improvement can be achieved, we used the second approach as an example and implemented a parallel version for a multi-core computer cluster. Finally we used a novel way to visualize the calculated chemical compositions, by which domain scientists could grasp the percentage difference easily without looking into the real data.

  9. Redox and speciation mapping of rock thin sections using high spatial resolution full-field imaging technique

    NASA Astrophysics Data System (ADS)

    de Andrade, V.; Susini, J.; Salomé, M.; Beraldin, O.; Heymes, T.; Lewin, E.

    2009-04-01

    Because of their complex genesis, natural rocks are the most often heterogeneous systems, with various scale-level heterogeneities for both chemistry and structure. In the last decade, the dramatic improvements of hyperspectral imaging techniques provided new tools for accurate material characterisation. Most of these micro- and nano- analytical techniques rely on scanning instruments, which offer high spatial resolution but suffer from long acquisition times imposing practical limits on the field of view. Conversely, full-field imaging techniques rely on a fast parallel acquisition but have limited resolution. Although soft X-ray full-field microscopes based on Fresnel zone plates are commonly used for high resolution imaging, its combination with spectroscopy is challenging and 2D chemical mapping still difficult. For harder X-rays, lensless X-ray microscope based on simple propagation geometry is easier and can be readily used for 2D spectro-microscopy. A full-field experimental setup was optimized at the ESRF-ID21 beamline to image iron redox and speciation distributions in rocks thin sections. The setup comprises a Si111 or Si220 (E = 0.4 eV) monochromator, a special sample stage and a sensitive camera associated with a brand new GGG:Eu light conversion scintillator and high magnification visible light optics. The pixel size ranges from 1.6 to 0.16 m according to the optic used. This instrument was used to analyse phyllosilicates and oxides of metamorphic sediments coming from the Aspromonte nappes-pile in Calabria. Iron chemical state distributions were derived - from images of 1000 Ã- 2000 Ã- 30 m3 rock thin sections - by subtraction of absorption images above and below the Fe K-edge. Using an automatic stitching reconstruction, a wide field image (4Ã-3 mm2 with a 1 m2 resolution for a total of about 12 millions pixels) of Fetotal elemental distribution was produced. Moreover, -XANES analyses (more than 1 million individual -XANES spectra) were performed

  10. Laser Doppler dust devil measurements

    NASA Technical Reports Server (NTRS)

    Bilbro, J. W.; Jeffreys, H. B.; Kaufman, J. W.; Weaver, E. A.

    1977-01-01

    A scanning laser doppler velocimeter (SLDV) system was used to detect, track, and measure the velocity flow field of naturally occurring tornado-like flows (dust devils) in the atmosphere. A general description of the dust devil phenomenon is given along with a description of the test program, measurement system, and data processing techniques used to collect information on the dust devil flow field. The general meteorological conditions occurring during the test program are also described, and the information collected on two selected dust devils are discussed in detail to show the type of information which can be obtained with a SLDV system. The results from these measurements agree well with those of other investigators and illustrate the potential for the SLDV in future endeavors.

  11. Enhancement of the resolution of full-field optical coherence tomography by using a colour image sensor

    SciTech Connect

    Kalyanov, A L; Lychagov, V V; Smirnov, I V; Ryabukho, V P

    2013-08-31

    The influence of white balance in a colour image detector on the resolution of a full-field optical coherence tomograph (FFOCT) is studied. The change in the interference pulse width depending on the white balance tuning is estimated in the cases of a thermal radiation source (incandescent lamp) and a white light emitting diode. It is shown that by tuning white balance of the detector in a certain range, the FFOCT resolution can be increased by 20 % as compared to the resolution, attained with the use of a monochrome detector. (optical coherence tomography)

  12. 3D Imaging of Nickel Oxidation States using Full Field X-ray Absorption Near Edge Structure Nanotomography

    SciTech Connect

    Nelson, George; Harris, William; Izzo, John; Grew, Kyle N.

    2012-01-20

    Reduction-oxidation (redox) cycling of the nickel electrocatalyst phase in the solid oxide fuel cell (SOFC) anode can lead to performance degradation and cell failure. A greater understanding of nickel redox mechanisms at the microstructural level is vital to future SOFC development. Transmission x-ray microscopy (TXM) provides several key techniques for exploring oxidation states within SOFC electrode microstructure. Specifically, x-ray nanotomography and x-ray absorption near edge structure (XANES) spectroscopy have been applied to study samples of varying nickel (Ni) and nickel oxide (NiO) compositions. The imaged samples are treated as mock SOFC anodes containing distinct regions of the materials in question. XANES spectra presented for the individual materials provide a basis for the further processing and analysis of mixed samples. Images of composite samples obtained are segmented, and the distinct nickel and nickel oxide phases are uniquely identified using full field XANES spectroscopy. Applications to SOFC analysis are discussed.

  13. Super-resolved image acquisition with full-field localization-based microscopy: theoretical analysis and evaluation

    NASA Astrophysics Data System (ADS)

    Son, Taehwang; Lee, Wonju; Kim, Donghyun

    2016-02-01

    We analyze and evaluate super-resolved image acquisition with full-field localization microscopy in which an individual signal sampled by localization may or may not be switched. For the analysis, Nyquist-Shannon sampling theorem based on ideal delta function was extended to sampling with unit pulse comb and surface-enhanced localized near-field that was numerically calculated with finite difference time domain. Sampling with unit pulse was investigated in Fourier domain where magnitude of baseband becomes larger than that of adjacent subband, i.e. aliasing effect is reduced owing to pulse width. Standard Lena image was employed as imaging target and a diffraction-limited optical system is assumed. A peak signal-to-noise ratio (PSNR) was introduced to evaluate the efficiency of image reconstruction quantitatively. When the target was sampled without switching by unit pulse as the sampling width and period are varied, PSNR increased eventually to 18.1 dB, which is the PSNR of a conventional diffraction-limited image. PSNR was found to increase with a longer pulse width due to reduced aliasing effect. When switching of individual sampling pulses was applied, blurry artifact outside the excited field is removed for each pulse and PSNR soars to 25.6 dB with a shortened pulse period, i.e. effective resolution of 72 nm is obtained, which can further be decreased.

  14. Laser Doppler velocimeter system simulation for sensing aircraft wake vortices

    NASA Technical Reports Server (NTRS)

    Thomson, J. A. L.; Meng, J. C. S.

    1974-01-01

    A hydrodynamic model of aircraft vortex wakes in an irregular wind shear field near the ground is developed and used as a basis for modeling the characteristics of a laser Doppler detection and vortex location system. The trailing vortex sheet and the wind shear are represented by discrete free vortices distributed over a two-dimensional grid. The time dependent hydrodynamic equations are solved by direct numerical integration in the Boussinesq approximation. The ground boundary is simulated by images, and fast Fourier Transform techniques are used to evaluate the vorticity stream function. The atmospheric turbulence was simulated by constructing specific realizations at time equal to zero, assuming that Kolmogoroff's law applies, and that the dissipation rate is constant throughout the flow field. The response of a simulated laser Doppler velocimeter is analyzed by simulating the signal return from the flow field as sensed by a simulation of the optical/electronic system.

  15. Imaging vascular dynamics in human retina using full-field swept-source optical coherence tomography (Conference Presentation)

    NASA Astrophysics Data System (ADS)

    Spahr, Hendrik; Hillmann, Dierck; Hain, Carola; Pfäffle, Clara; Sudkamp, Helge; Franke, Gesa; Hüttmann, Gereon

    2016-03-01

    We demonstrate a new non-invasive method to assess the functional condition of the retinal vascular system. Phase-sensitive full-field swept-source optical coherence tomography (PhS-FF-SS-OCT) is used to investigate retinal vascular dynamics at unprecedented temporal resolution. Motion of retinal tissue, that is induced by expansion of the vessels therein, is measured with an accuracy of about 10 nm. The pulse shape of arterial and venous pulsation, their temporal delay as well as the frequency dependent pulse propagation through the capillary bed are determined. For the first time, imaging speed and motion sensitivity are sufficient for a direct measurement of pulse waves propagating with more than 600 mm/s in retinal vessels of a healthy young subject.

  16. A Full-Field KB-FZP Microscope for Hard X-Ray Imaging with Sub 100 nm Resolution

    SciTech Connect

    Rau, C.; Crecea, V.; Peterson, K.M.; Jemian, P.R.; Richter, C.-P.; Neuhausler, U.; Schmeider, G.; Yu, X.; Braun, P.V.; Robinson, I.K.

    2007-06-28

    A full-field hard X-ray microscope has been built at the UNICAT/APS beamline 34ID-C. A Kirkpatrick-Baez mirror is used for the condenser and a micro-Fresnel Zone Plate (FZP) as the objective lens. The zone plates available give access to 50-85 nm spatial resolution operating the microscope between 6-12keV photon energy. The first tomography experiments have been performed with this device. A KB-FZP microscope has been built for sub-100 nm imaging and tomography. Features of 50 nm have been visualized at 9 keV photon energy. A 40 x 20 microns field of view of can be imaged in a minute. The first tomography experiments have been performed with this device. Further, it is planned to apply phase contrast techniques, such as the Zernike method. Both the efficiency and the resolution of the instrument can be further improved. A more efficient zone plate and an improved detector will reduce the exposure times and the use of the 50x100 times more intense so called 'pink-beam' is possible. To improve the resolution, the zone plates deliver in their third order a resolution of 15 nm. A KB-FZP microscope has been built for sub-100 nm imaging and tomography. Features of 50 nm have been visualized at 9 keV photon energy. A 40 x 20 microns field of view of can be imaged in seconds. Tomography experiments have been performed with this device. Phase objects have been visualized taking image series. Phase contrast techniques, such as the Zernike method will be tested in the future. Both the efficiency and the resolution of the instrument can be further improved. Together with the instrument for In-line phase contrast imaging the nano- and micrometer lenghtscale is covered.

  17. Three-dimensional imaging of chemical phase transformations at the nanoscale with full-field transmission X-ray microscopy

    PubMed Central

    Meirer, Florian; Cabana, Jordi; Liu, Yijin; Mehta, Apurva; Andrews, Joy C.; Pianetta, Piero

    2011-01-01

    The ability to probe morphology and phase distribution in complex systems at multiple length scales unravels the interplay of nano- and micrometer-scale factors at the origin of macroscopic behavior. While different electron- and X-ray-based imaging techniques can be combined with spectroscopy at high resolutions, owing to experimental time limitations the resulting fields of view are too small to be representative of a composite sample. Here a new X-ray imaging set-up is proposed, combining full-field transmission X-ray microscopy (TXM) with X-ray absorption near-edge structure (XANES) spectroscopy to follow two-dimensional and three-dimensional morphological and chemical changes in large volumes at high resolution (tens of nanometers). TXM XANES imaging offers chemical speciation at the nanoscale in thick samples (>20 µm) with minimal preparation requirements. Further, its high throughput allows the analysis of large areas (up to millimeters) in minutes to a few hours. Proof of concept is provided using battery electrodes, although its versatility will lead to impact in a number of diverse research fields. PMID:21862859

  18. Three-dimensional imaging of chemical phase transformations at the nanoscale with full-field transmission X-ray microscopy.

    PubMed

    Meirer, Florian; Cabana, Jordi; Liu, Yijin; Mehta, Apurva; Andrews, Joy C; Pianetta, Piero

    2011-09-01

    The ability to probe morphology and phase distribution in complex systems at multiple length scales unravels the interplay of nano- and micrometer-scale factors at the origin of macroscopic behavior. While different electron- and X-ray-based imaging techniques can be combined with spectroscopy at high resolutions, owing to experimental time limitations the resulting fields of view are too small to be representative of a composite sample. Here a new X-ray imaging set-up is proposed, combining full-field transmission X-ray microscopy (TXM) with X-ray absorption near-edge structure (XANES) spectroscopy to follow two-dimensional and three-dimensional morphological and chemical changes in large volumes at high resolution (tens of nanometers). TXM XANES imaging offers chemical speciation at the nanoscale in thick samples (>20 µm) with minimal preparation requirements. Further, its high throughput allows the analysis of large areas (up to millimeters) in minutes to a few hours. Proof of concept is provided using battery electrodes, although its versatility will lead to impact in a number of diverse research fields. PMID:21862859

  19. Rapid and high-resolution imaging of human liver specimens by full-field optical coherence tomography

    NASA Astrophysics Data System (ADS)

    Zhu, Yue; Gao, Wanrong; Zhou, Yuan; Guo, Yingcheng; Guo, Feng; He, Yong

    2015-11-01

    We report rapid and high-resolution tomographic en face imaging of human liver specimens by full-field optical coherence tomography (FF-OCT). First, the arrangement of the FF-OCT system was described and the performance of the system was measured. The measured axial and lateral resolutions of the system are 0.8 and 0.9 μm, respectively. The system has a sensitivity of ˜60 dB and can achieve an imaging rate of 7 fps and a penetration depth of ˜80 μm. The histological structures of normal liver can be seen clearly in the en face tomographic images, including central veins, cords of hepatocytes separated by sinusoidal spaces, and portal area (portal vein, the hepatic arteriole, and the bile duct). A wide variety of histological subtypes of hepatocellular carcinoma was observed in en face tomographic images, revealing notable cancerous features, including the nuclear atypia (enlarged convoluted nuclei), the polygonal tumor cells with obvious resemblance to hepatocytes with enlarged nuclei. In addition, thicker fibrous bands, which make the cytoplasmic plump vesicular nuclei indistinct, were also seen in the images. Finally, comparison between the portal vein in a normal specimen versus that seen in the rare type of cholangiocarcinoma was made. The results show that the cholangiocarcinoma presents with a blurred pattern of portal vein in the lateral direction and an aggregated distribution in the axial direction; the surrounding sinusoidal spaces and nuclei of cholangiocarcinoma are absent. The findings in this work may be used as additional signs of liver cancer or cholangiocarcinoma, demonstrating capacity of FF-OCT device for early cancer diagnosis and many other tumor-related studies in biopsy.

  20. A full-field transmission x-ray microscope for time-resolved imaging of magnetic nanostructures

    NASA Astrophysics Data System (ADS)

    Ewald, J.; Wessels, P.; Wieland, M.; Nisius, T.; Vogel, A.; Abbati, G.; Baumbach, S.; Overbuschmann, J.; Viefhaus, J.; Meier, G.; Wilhein, T.; Drescher, M.

    2016-01-01

    Sub-nanosecond magnetization dynamics of small permalloy (Ni80Fe20) elements has been investigated with a new full-field transmission microscope at the soft X-ray beamline P04 of the high brilliance synchrotron radiation source PETRA III. The soft X-ray microscope generates a flat-top illumination field of 20 μm diameter using a grating condenser. A tilted nanostructured magnetic sample can be excited by a picosecond electric current pulse via a coplanar waveguide. The transmitted light of the sample plane is directly imaged by a micro zone plate with < 65 nm resolution onto a 2D gateable X-ray detector to select one particular bunch in the storage ring that probes the time evolution of the dynamic information successively via XMCD spectromicroscopy in a pump-probe scheme. In the experiments it was possible to generate a homogeneously magnetized state in patterned magnetic layers by a strong magnetic Oersted field pulse of 200 ps duration and directly observe the recovery to the initial flux-closure vortex patterns.

  1. Laser Doppler velocimeter aerial spray measurements

    NASA Technical Reports Server (NTRS)

    Zalay, A. D.; Eberle, W. R.; Howle, R. E.; Shrider, K. R.

    1978-01-01

    An experimental research program for measuring the location, spatial extent, and relative concentration of airborne spray clouds generated by agricultural aircraft is described. The measurements were conducted with a ground-based laser Doppler velocimeter. The remote sensing instrumentation, experimental tests, and the results of the flight tests are discussed. The cross section of the aerial spray cloud and the observed location, extent, and relative concentration of the airborne particulates are presented. It is feasible to use a mobile laser Doppler velocimeter to track and monitor the transport and dispersion of aerial spray generated by an agricultural aircraft.

  2. Is there a difference between laser speckle and laser Doppler in depth sensitivity?

    NASA Astrophysics Data System (ADS)

    Thompson, O. B.; Hirst, E. R.; Andrews, M. K.

    2011-03-01

    Laser speckle and laser Doppler perfusion measurements apply different analyses to the same physical phenomenon and so should produce the same results. However, there is some evidence that laser Doppler can measure perfusion at greater depths than laser speckle. Using phantom measurements and comparison to spatially modulated imaging, we show why this might be the case. Various implementations of imaging laser Doppler and speckle systems have different optical setups, producing different effective distances between the illumination and detector points on the surface of the tissue. Separating the effective source and detector regions in tissue measurements biases the measurements towards deeper tissues, and when the effective source and detector regions coincide, the measurement is biased towards surface tissues. Probe-based or scanning laser Doppler systems with point illumination can separate the source and detector regions to interrogate deeper tissues, while whole-field imaging laser Doppler systems and laser speckle contrast systems have broad illumination covering the measurement areas. The volume of tissue informing a measurement at any point in a whole-field system, and hence the depth sensitivity, is determined by the optical properties of the tissue at the working wavelength.

  3. Breast Imaging Reporting and Data System (BI-RADS) breast composition descriptors: Automated measurement development for full field digital mammography

    SciTech Connect

    Fowler, E. E.; Sellers, T. A.; Lu, B.; Heine, J. J.

    2013-11-15

    Purpose: The Breast Imaging Reporting and Data System (BI-RADS) breast composition descriptors are used for standardized mammographic reporting and are assessed visually. This reporting is clinically relevant because breast composition can impact mammographic sensitivity and is a breast cancer risk factor. New techniques are presented and evaluated for generating automated BI-RADS breast composition descriptors using both raw and calibrated full field digital mammography (FFDM) image data.Methods: A matched case-control dataset with FFDM images was used to develop three automated measures for the BI-RADS breast composition descriptors. Histograms of each calibrated mammogram in the percent glandular (pg) representation were processed to create the new BR{sub pg} measure. Two previously validated measures of breast density derived from calibrated and raw mammograms were converted to the new BR{sub vc} and BR{sub vr} measures, respectively. These three measures were compared with the radiologist-reported BI-RADS compositions assessments from the patient records. The authors used two optimization strategies with differential evolution to create these measures: method-1 used breast cancer status; and method-2 matched the reported BI-RADS descriptors. Weighted kappa (κ) analysis was used to assess the agreement between the new measures and the reported measures. Each measure's association with breast cancer was evaluated with odds ratios (ORs) adjusted for body mass index, breast area, and menopausal status. ORs were estimated as per unit increase with 95% confidence intervals.Results: The three BI-RADS measures generated by method-1 had κ between 0.25–0.34. These measures were significantly associated with breast cancer status in the adjusted models: (a) OR = 1.87 (1.34, 2.59) for BR{sub pg}; (b) OR = 1.93 (1.36, 2.74) for BR{sub vc}; and (c) OR = 1.37 (1.05, 1.80) for BR{sub vr}. The measures generated by method-2 had κ between 0.42–0.45. Two of these measures

  4. Considerations for Calibrating a Laser Doppler Anemometer

    SciTech Connect

    Duncan, Michael L; Keck, Joe

    2010-01-01

    Laser Doppler Anemometers have long been the device-of-choice for air velocity measurements due to their avoidance of turbulence induced by insertion-method air velocity measurement devices. At first glance, the use of a Laser Doppler Anemometer (LDA) for calibrating air velocity meters appears to be a relatively simple and straightforward process. As is typical in most metrological applications the process becomes much more complex when attempting to use the apparatus to make high-performance, metrology measurements. This paper focuses on the considerations for calibration of a LDA beginning with a discussion why an LDA needs to be calibrated. Other areas of discussion include alignment of the optics, dealing with imperfections in the alignment process, establishing the traceability of measurements from the apparatus and design and development of and experiences with using a calibration apparatus.

  5. Should processed or raw image data be used in mammographic image quality analyses? A comparative study of three full-field digital mammography systems.

    PubMed

    Borg, Mark; Badr, Ishmail; Royle, Gary

    2015-01-01

    The purpose of this study is to compare a number of measured image quality parameters using processed and unprocessed or raw images in two full-field direct digital units and one computed radiography mammography system. This study shows that the difference between raw and processed image data is system specific. The results have shown that there are no significant differences between raw and processed data in the mean threshold contrast values using the contrast-detail mammography phantom in all the systems investigated; however, these results cannot be generalised to all available systems. Notable differences were noted in contrast-to-noise ratios and in other tests including: response function, modulation transfer function , noise equivalent quanta, normalised noise power spectra and detective quantum efficiency as specified in IEC 62220-1-2. Consequently, the authors strongly recommend the use of raw data for all image quality analyses in digital mammography.

  6. 3D camera assisted fully automated calibration of scanning laser Doppler vibrometers

    NASA Astrophysics Data System (ADS)

    Sels, Seppe; Ribbens, Bart; Mertens, Luc; Vanlanduit, Steve

    2016-06-01

    Scanning laser Doppler vibrometers (LDV) are used to measure full-field vibration shapes of products and structures. In most commercially available scanning laser Doppler vibrometer systems the user manually draws a grid of measurement locations on a 2D camera image of the product. The determination of the correct physical measurement locations can be a time consuming and diffcult task. In this paper we present a new methodology for product testing and quality control that integrates 3D imaging techniques with vibration measurements. This procedure allows to test prototypes in a shorter period because physical measurements locations will be located automatically. The proposed methodology uses a 3D time-of-flight camera to measure the location and orientation of the test-object. The 3D image of the time-of-flight camera is then matched with the 3D-CAD model of the object in which measurement locations are pre-defined. A time of flight camera operates strictly in the near infrared spectrum. To improve the signal to noise ratio in the time-of-flight measurement, a time-of-flight camera uses a band filter. As a result of this filter, the laser spot of most laser vibrometers is invisible in the time-of-flight image. Therefore a 2D RGB-camera is used to find the laser-spot of the vibrometer. The laser spot is matched to the 3D image obtained by the time-of-flight camera. Next an automatic calibration procedure is used to aim the laser at the (pre)defined locations. Another benefit from this methodology is that it incorporates automatic mapping between a CAD model and the vibration measurements. This mapping can be used to visualize measurements directly on a 3D CAD model. Secondly the orientation of the CAD model is known with respect to the laser beam. This information can be used to find the direction of the measured vibration relatively to the surface of the object. With this direction, the vibration measurements can be compared more precisely with numerical

  7. Comparison of Image Quality Criteria between Digital Storage Phosphor Plate in Mammography and Full-Field Digital Mammography in the Detection of Breast Cancer

    PubMed Central

    Thevi Rajendran, Pushpa; Krishnapillai, Vijayalakshmi; Tamanang, Sulaiman; Kumari Chelliah, Kanaga

    2012-01-01

    Background: Digital mammography is slowly replacing screen film mammography. In digital mammography, 2 methods are available in acquiring images: digital storage phosphor plate and full-field digital mammography. The aim of this study was to compare the image quality acquired from the 2 methods of digital mammography in the detection of breast cancer. Methods: The study took place at the National Cancer Society, Kuala Lumpur, and followed 150 asymptomatic women for the duration of 1 year. Participating women gave informed consent and were exposed to 4 views from each system. Two radiologists independently evaluated the printed images based on the image quality criteria in mammography. McNemar’s test was used to compare the image quality criteria between the systems. Results: The agreement between the radiologists for the digital storage phosphor plate was к = 0.551 and for full-field digital mammography was к = 0.523. Full-field digital mammography was significantly better compared with the digital storage phosphor plate in right and left mediolateral oblique views (P < 0.05) in the detection of microcalcifications, which are early signs of breast cancer. However, both systems were comparable in all other aspects of image quality. Conclusion: Digital mammography is a useful screening tool for the detection of early breast cancer and ensures better prognosis and quality of life. PMID:22977375

  8. High-Power Terahertz Source Opens the Door for Full-Field Video-Rate Terahertz Imaging

    SciTech Connect

    Klopf, John; Coppinger, Matthew; Sustersic, Nathan; Kolodzey, James; Williams, Gwyn

    2008-07-01

    Terahertz (THz) light, at wavelengths between electronics and photonics, promises novel imaging applications such as revealing epithelial carcinomas 1 or identifying objects hidden in clothing and packages 2. But THz imaging has been little exploited because generating source power high enough for adequate signal detection is difficult -- and because even more power is needed for most applications that require detecting scattered light rather than light transmitted straight through the target 3. The ability to image movement in real time would aid medicine by allowing the rapid viewing of multiple perspectives and larger areas for detecting skin cancer. Real-time imaging is also essential for the efficient detection, with sufficient resolution, of hidden, and possibly moving, objects. Here, in work building on our earlier demonstration that relativistic electrons can yield tens of watts of broadband THz light 4, 5, we report the first video-rate THz movies of objects observed in real t

  9. Velocity precision measurements using laser Doppler anemometry

    NASA Astrophysics Data System (ADS)

    Dopheide, D.; Taux, G.; Narjes, L.

    1985-07-01

    A Laser Doppler Anemometer (LDA) was calibrated to determine its applicability to high pressure measurements (up to 10 bars) for industrial purposes. The measurement procedure with LDA and the experimental computerized layouts are presented. The calibration procedure is based on absolute accuracy of Doppler frequency and calibration of interference strip intervals. A four-quadrant detector allows comparison of the interference strip distance measurements and computer profiles. Further development of LDA is recommended to increase accuracy (0.1% inaccuracy) and to apply the method industrially.

  10. Mobile fiber-optic laser Doppler anemometer.

    PubMed

    Stieglmeier, M; Tropea, C

    1992-07-20

    A laser Doppler anemometer (LDA) has been developed that combines the compactness and low power consumption of laser diodes and avalanche photodiodes with the flexibility and possibility of miniaturization by using fiber-optic probes. The system has been named DFLDA for laser diode fiber LDA and is especially suited for mobile applications, for example, in trains, airplanes, or automobiles. Optimization considerations of fiber-optic probes are put forward and several probe examples are described in detail. Measurement results from three typical applications are given to illustrate the use of the DFLDA. Finally, a number of future configurations of the DFLDA concept are discussed.

  11. Catadioptric optics for laser Doppler velocimeter applications

    NASA Technical Reports Server (NTRS)

    Dunagan, Stephen E.

    1989-01-01

    This paper examines the adaptation of low-cost Schmidt-Cassegrain astronomical telescopes to perform the laser-beam-focusing and scattered-light collection tasks associated with dual-beam laser Doppler velocimetry. A generic telescope design is analyzed using ray-tracing methods and Gaussian beam-propagation theory. A straightforward modification procedure to convert from infinite to near unity conjugate-ratio operation with very low residual aberration is identified and tested with a 200-mm-aperture telescope modified for f/10 operation. Performance data for this modified telescope configuration are near the diffraction limit and agree well with predictions.

  12. Laser Doppler anemometry measurements in an engine.

    PubMed

    Cole, J B; Swords, M D

    1979-05-15

    A simple and effective technique is reported which allows measurement of the flow field in the cylinder of a motored internal combustion engine with good temporal and spatial resolution. The experiment, a realfringe laser Doppler anemometer, uses photon counting digital autocorrelation for data capture. The experimental autocorrelation functions have been processed using curve-fitting to a Gaussian velocity profile and by direct Fourier transformation without prior assumption of the form. The ability of such a technique to tolerate poor SNRs makes it a likely choice for measurement in firing engines.

  13. Comparison of full-field digital mammography workstation and conventional picture archiving and communication system in image quality and diagnostic performance.

    PubMed

    Kang, Bong Joo; Kim, Sung Hun; Choi, Byung Gil

    2011-01-01

    The object of this study was to compare of full-field digital mammography (FFDM) workstation and conventional picture archiving and communication systems (PACS) in image quality and diagnostic performance. We assembled 80 masses and 80 microcalcifications. Images were displayed on workstation, 5M, and 3M PACS monitors. The image quality for mammograms on workstation was significantly better than that for mammograms on PACS monitors. The sensitivity and NPV for microcalcifications on workstation were higher than those on PACS monitors. The conventional PACS cannot substitute for a FFDM workstation for mammographic evaluation.

  14. Assessment of the metrological performance of an in situ storage image sensor ultra-high speed camera for full-field deformation measurements

    NASA Astrophysics Data System (ADS)

    Rossi, Marco; Pierron, Fabrice; Forquin, Pascal

    2014-02-01

    Ultra-high speed (UHS) cameras allow us to acquire images typically up to about 1 million frames s-1 for a full spatial resolution of the order of 1 Mpixel. Different technologies are available nowadays to achieve these performances, an interesting one is the so-called in situ storage image sensor architecture where the image storage is incorporated into the sensor chip. Such an architecture is all solid state and does not contain movable devices as occurs, for instance, in the rotating mirror UHS cameras. One of the disadvantages of this system is the low fill factor (around 76% in the vertical direction and 14% in the horizontal direction) since most of the space in the sensor is occupied by memory. This peculiarity introduces a series of systematic errors when the camera is used to perform full-field strain measurements. The aim of this paper is to develop an experimental procedure to thoroughly characterize the performance of such kinds of cameras in full-field deformation measurement and identify the best operative conditions which minimize the measurement errors. A series of tests was performed on a Shimadzu HPV-1 UHS camera first using uniform scenes and then grids under rigid movements. The grid method was used as full-field measurement optical technique here. From these tests, it has been possible to appropriately identify the camera behaviour and utilize this information to improve actual measurements.

  15. Polarization calibration with large apertures in full field of view for a full Stokes imaging polarimeter based on liquid-crystal variable retarders.

    PubMed

    Zhang, Ying; Zhao, Huijie; Li, Na

    2013-02-20

    Currently, polarization calibration for full Stokes imaging polarimeters is limited by the apertures of the retarders. In this paper, an improved polarization calibration with large apertures in full field of view for full Stokes imaging polarimeters based on liquid-crystal variable retarders is proposed and investigated theoretically and experimentally. The experimental precision of polarization calibration is 1.7% for linear polarization states and 8.8% for circular ones for an imaging polarimeter with a 100 mm aperture and 10° field of view. The feasibility for full Stokes polarization image is also confirmed in experiment for identifying objects due to degree of polarization and degree of circular polarization images. PMID:23435001

  16. A laboratory 8 keV transmission full-field x-ray microscope with a polycapillary as condenser for bright and dark field imaging

    NASA Astrophysics Data System (ADS)

    Baumbach, S.; Kanngießer, B.; Malzer, W.; Stiel, H.; Wilhein, T.

    2015-08-01

    This article introduces a laboratory setup of a transmission full-field x-ray microscope at 8 keV photon energy. The microscope operates in bright and dark field imaging mode with a maximum field of view of 50 μm. Since the illumination geometry determines whether the sample is illuminated homogeneously and moreover, if different imaging methods can be applied, the condenser optic is one of the most significant parts. With a new type of x-ray condenser, a polycapillary optic, we realized bright field imaging and for the first time dark field imaging at 8 keV photon energy in a laboratory setup. A detector limited spatial resolution of 210 nm is measured on x-ray images of Siemens star test patterns.

  17. A laboratory 8 keV transmission full-field x-ray microscope with a polycapillary as condenser for bright and dark field imaging

    SciTech Connect

    Baumbach, S. Wilhein, T.; Kanngießer, B.; Malzer, W.; Stiel, H.

    2015-08-15

    This article introduces a laboratory setup of a transmission full-field x-ray microscope at 8 keV photon energy. The microscope operates in bright and dark field imaging mode with a maximum field of view of 50 μm. Since the illumination geometry determines whether the sample is illuminated homogeneously and moreover, if different imaging methods can be applied, the condenser optic is one of the most significant parts. With a new type of x-ray condenser, a polycapillary optic, we realized bright field imaging and for the first time dark field imaging at 8 keV photon energy in a laboratory setup. A detector limited spatial resolution of 210 nm is measured on x-ray images of Siemens star test patterns.

  18. Laser Doppler systems in atmospheric turbulence

    NASA Technical Reports Server (NTRS)

    Murty, S. S. R.

    1976-01-01

    The loss of heterodyne signal power for the Marshall Space Flight Center laser Doppler system due to the random changes in the atmospheric index of refraction is investigated. The current status in the physics of low energy laser propagation through turbulent atmosphere is presented. The analysis and approximate evaluation of the loss of the heterodyne signal power due to the atmospheric absorption, scattering, and turbulence are estimated for the conditions of the January 1973 flight tests. Theoretical and experimental signal to noise values are compared. Maximum and minimum values of the atmospheric attenuation over a two way path of 20 km range are calculated as a function of altitude using models of atmosphere, aerosol concentration, and turbulence.

  19. Effect of the Availability of Prior Full-Field Digital Mammography and Digital Breast Tomosynthesis Images on the Interpretation of Mammograms

    PubMed Central

    Catullo, Victor J.; Chough, Denise M.; Ganott, Marie A.; Kelly, Amy E.; Shinde, Dilip D.; Sumkin, Jules H.; Wallace, Luisa P.; Bandos, Andriy I.; Gur, David

    2015-01-01

    Purpose To assess the effect of and interaction between the availability of prior images and digital breast tomosynthesis (DBT) images in decisions to recall women during mammogram interpretation. Materials and Methods Verbal informed consent was obtained for this HIPAA-compliant institutional review board–approved protocol. Eight radiologists independently interpreted twice deidentified mammograms obtained in 153 women (age range, 37–83 years; mean age, 53.7 years ± 9.3 [standard deviation]) in a mode by reader by case-balanced fully crossed study. Each study consisted of current and prior full-field digital mammography (FFDM) images and DBT images that were acquired in our facility between June 2009 and January 2013. For one reading, sequential ratings were provided by using (a) current FFDM images only, (b) current FFDM and DBT images, and (c) current FFDM, DBT, and prior FFDM images. The other reading consisted of (a) current FFDM images only, (b) current and prior FFDM images, and (c) current FFDM, prior FFDM, and DBT images. Fifty verified cancer cases, 60 negative and benign cases (clinically not recalled), and 43 benign cases (clinically recalled) were included. Recall recommendations and interaction between the effect of prior FFDM and DBT images were assessed by using a generalized linear model accounting for case and reader variability. Results Average recall rates in noncancer cases were significantly reduced with the addition of prior FFDM images by 34% (145 of 421) and 32% (106 of 333) without and with DBT images, respectively (P < .001). However, this recall reduction was achieved at the cost of a corresponding 7% (23 of 345) and 4% (14 of 353) reduction in sensitivity (P = .006). In contrast, availability of DBT images resulted in a smaller reduction in recall rates (false-positive interpretations) of 19% (76 of 409) and 26% (71 of 276) without and with prior FFDM images, respectively (P = .001). Availability of DBT images resulted in 4% (15 of

  20. A full-field and real-time 3D surface imaging augmented DOT system for in-vivo small animal studies

    NASA Astrophysics Data System (ADS)

    Yi, Steven X.; Yang, Bingcheng; Yin, Gongjie

    2010-02-01

    A crucial parameter in Diffuse Optical Tomography (DOT) is the construction of an accurate forward model, which greatly depends on tissue boundary. Since photon propagation is a three-dimensional volumetric problem, extraction and subsequent modeling of three-dimensional boundaries is essential. Original experimental demonstration of the feasibility of DOT to reconstruct absorbers, scatterers and fluorochromes used phantoms or tissues confined appropriately to conform to easily modeled geometries such as a slab or a cylinder. In later years several methods have been developed to model photon propagation through diffuse media with complex boundaries using numerical solutions of the diffusion or transport equation (finite elements or differences) or more recently analytical methods based on the tangent-plane method . While optical examinations performed simultaneously with anatomical imaging modalities such as MRI provide well-defined boundaries, very limited progress has been done so far in extracting full-field (360 degree) boundaries for in-vivo three-dimensional DOT stand-alone imaging. In this paper, we present a desktop multi-spectrum in-vivo 3D DOT system for small animal imaging. This system is augmented with Technest's full-field 3D cameras. The built system has the capability of acquiring 3D object surface profiles in real time and registering 3D boundary with diffuse tomography. Extensive experiments are performed on phantoms and small animals by our collaborators at the Center for Molecular Imaging Research (CMIR) at Massachusetts General Hospital (MGH) and Harvard Medical School. Data has shown successful reconstructed DOT data with improved accuracy.

  1. Muscle activity characterization by laser Doppler Myography

    NASA Astrophysics Data System (ADS)

    Scalise, Lorenzo; Casaccia, Sara; Marchionni, Paolo; Ercoli, Ilaria; Primo Tomasini, Enrico

    2013-09-01

    Electromiography (EMG) is the gold-standard technique used for the evaluation of muscle activity. This technique is used in biomechanics, sport medicine, neurology and rehabilitation therapy and it provides the electrical activity produced by skeletal muscles. Among the parameters measured with EMG, two very important quantities are: signal amplitude and duration of muscle contraction, muscle fatigue and maximum muscle power. Recently, a new measurement procedure, named Laser Doppler Myography (LDMi), for the non contact assessment of muscle activity has been proposed to measure the vibro-mechanical behaviour of the muscle. The aim of this study is to present the LDMi technique and to evaluate its capacity to measure some characteristic features proper of the muscle. In this paper LDMi is compared with standard superficial EMG (sEMG) requiring the application of sensors on the skin of each patient. sEMG and LDMi signals have been simultaneously acquired and processed to test correlations. Three parameters has been analyzed to compare these techniques: Muscle activation timing, signal amplitude and muscle fatigue. LDMi appears to be a reliable and promising measurement technique allowing the measurements without contact with the patient skin.

  2. Computing mammographic density from a multiple regression model constructed with image-acquisition parameters from a full-field digital mammographic unit

    NASA Astrophysics Data System (ADS)

    Lu, Lee-Jane W.; Nishino, Thomas K.; Khamapirad, Tuenchit; Grady, James J.; Leonard, Morton H., Jr.; Brunder, Donald G.

    2007-08-01

    Breast density (the percentage of fibroglandular tissue in the breast) has been suggested to be a useful surrogate marker for breast cancer risk. It is conventionally measured using screen-film mammographic images by a labor-intensive histogram segmentation method (HSM). We have adapted and modified the HSM for measuring breast density from raw digital mammograms acquired by full-field digital mammography. Multiple regression model analyses showed that many of the instrument parameters for acquiring the screening mammograms (e.g. breast compression thickness, radiological thickness, radiation dose, compression force, etc) and image pixel intensity statistics of the imaged breasts were strong predictors of the observed threshold values (model R2 = 0.93) and %-density (R2 = 0.84). The intra-class correlation coefficient of the %-density for duplicate images was estimated to be 0.80, using the regression model-derived threshold values, and 0.94 if estimated directly from the parameter estimates of the %-density prediction regression model. Therefore, with additional research, these mathematical models could be used to compute breast density objectively, automatically bypassing the HSM step, and could greatly facilitate breast cancer research studies.

  3. X-ray absorption spectroscopy by full-field X-ray microscopy of a thin graphite flake: Imaging and electronic structure via the carbon K-edge

    PubMed Central

    Hitchock, Adam P; Ke, Xiaoxing; Van Tendeloo, Gustaaf; Ewels, Chris P; Guttmann, Peter

    2012-01-01

    Summary We demonstrate that near-edge X-ray-absorption fine-structure spectra combined with full-field transmission X-ray microscopy can be used to study the electronic structure of graphite flakes consisting of a few graphene layers. The flake was produced by exfoliation using sodium cholate and then isolated by means of density-gradient ultracentrifugation. An image sequence around the carbon K-edge, analyzed by using reference spectra for the in-plane and out-of-plane regions of the sample, is used to map and spectrally characterize the flat and folded regions of the flake. Additional spectral features in both π and σ regions are observed, which may be related to the presence of topological defects. Doping by metal impurities that were present in the original exfoliated graphite is indicated by the presence of a pre-edge signal at 284.2 eV. PMID:23016137

  4. Refractive lens based full-field x-ray imaging at 45-50 keV with sub-micron resolution

    NASA Astrophysics Data System (ADS)

    Shastri, S. D.; Kenesei, P.; Suter, R. M.

    2015-09-01

    Combining sub-micron spatial resolution full-field-imaging with the penetration property of high-energy x-rays (> 50 keV) offers numerous applications, such as the ability to observe cracks and voids associated with the onset of failure in engineering materials, complementing x-ray diffraction microscopy probes. Progress in the development of adding such an imaging capability at the Advanced Photon Source high-energy x-ray undulator beamline 1-ID is reported. An initially tested, long baseline configuration had 18-21× x-ray image magnification with compound refractive lenses (as objective) placed 1.8 m after the specimen, and a two-dimensional detector located at a 32-37 m additional distance, in a different experimental station. Later, a more compact set-up of 3.5× magnification with a ≍6 m sample-to-detector separation, fitting within a single end-station, was tested. Both set-ups demonstrated 500 nm level spatial resolutions at energies within the 45-50 keV range. Phase contrast artifacts are present, and are discussed in view of the goal of achieving tomography capability, at even higher resolution, in such an instrument with high x-ray energies.

  5. Interpreting laser Doppler recordings from free flaps.

    PubMed

    Svensson, H; Holmberg, J; Svedman, P

    1993-01-01

    Although the transfer of free flaps is nowadays accomplished with an increasing degree of safety, thrombosis of the microvascular anastomoses is still a problem. In order to avoid delay in re-operating, various methods for objective blood flow monitoring have been tried, among them Laser Doppler Flowmetry (LDF). When one reviews the literature, it is apparent that opinions differ about whether or not LDF is a reliable technique for this purpose. To focus on the need to interpret continuous recordings, this paper reports our findings in six latissimus dorsi free flaps chosen from our series of LDF monitoring procedures. One uneventful flap, no. 1, had an immediate postoperative LDF value of 4.5 perfusion units (PU). LDF values improved during the recovery period and the graphic recording showed fluctuations due to normal physiological variations of the blood flow in the flap. Another uneventful flap, no. 4, showed the same pattern, though at an appreciably lower level, 2 PU, on average. Flap no. 2 had an acceptably high value of 3.5 PU despite suffering a venous thrombosis. However, the LDF recording showed no fluctuations and the value declined gradually. Another flap, no. 3, showed fluctuations and blood flow was normal although the value decreased to 2.5 PU. In flap no. 5, any value between 2 and 3.5 PU could be obtained merely by adjusting the position of the probe in the holder. In no. 6, the LDF value suddenly dropped, accompanied by a decrease in the total amount of backscattered light, indicating venous obstruction which was confirmed at re-operation.(ABSTRACT TRUNCATED AT 250 WORDS)

  6. Application of wavelet analysis in laser Doppler vibration signal denoising

    NASA Astrophysics Data System (ADS)

    Lan, Yu-fei; Xue, Hui-feng; Li, Xin-liang; Liu, Dan

    2010-10-01

    Large number of experiments show that, due to external disturbances, the measured surface is too rough and other factors make use of laser Doppler technique to detect the vibration signal contained complex information, low SNR, resulting in Doppler frequency shift signals unmeasured, can not be demodulated Doppler phase and so on. This paper first analyzes the laser Doppler signal model and feature in the vibration test, and studies the most commonly used three ways of wavelet denoising techniques: the modulus maxima wavelet denoising method, the spatial correlation denoising method and wavelet threshold denoising method. Here we experiment with the vibration signals and achieve three ways by MATLAB simulation. Processing results show that the wavelet modulus maxima denoising method at low laser Doppler vibration SNR, has an advantage for the signal which mixed with white noise and contained more singularities; the spatial correlation denoising method is more suitable for denoising the laser Doppler vibration signal which noise level is not very high, and has a better edge reconstruction capacity; wavelet threshold denoising method has a wide range of adaptability, computational efficiency, and good denoising effect. Specifically, in the wavelet threshold denoising method, we estimate the original noise variance by spatial correlation method, using an adaptive threshold denoising method, and make some certain amendments in practice. Test can be shown that, compared with conventional threshold denoising, this method is more effective to extract the feature of laser Doppler vibration signal.

  7. Laser Doppler flowmetry: reproducibility, reliability, and diurnal blood flow variations.

    PubMed

    Roeykens, Herman J J; Deschepper, Ellen; De Moor, Roeland J G

    2016-08-01

    The aim of this investigation was (1) to evaluate the reliability of laser Doppler flowmetry (LDF) taking into consideration the use of a silicone splint and the inclination of the probe towards the buccal surface of a human tooth and (2) to determine whether diurnal variations of pulpal blood flow can be registered by means of LDF. Forty-one splints were made by one and the same principal investigator for the registration of pulpal blood flow in vivo in a maxillary right central incisor. Thirty dentists, without experience in LDF recording, were then asked to drill a right-angled shaft in a pre-manufactured splint with a referral point at 2 mm from the enamel-cement border central on the buccal surface of the right central upper incisor. The remaining 11 splints were handled by the principal investigator. The shafts in the 30 splints were analysed using Cone Beam CT imaging of the axial and sagittal angles and compared these to the 11 shafts prepared by the trained principal investigator. LDF was recorded for 90 s in each splint and statistically analysed. LDF values without the use of a splint were statistically significantly different (p < 0.05) and the variance was greater, indicating the superiority of splint use. Significant diurnal variations on LDF values were observed, indicating that special attention should be paid to registration during the day, especially when multiple measurements are to be compared.

  8. MO-A-BRD-01: An Investigation of the Dynamic Response of a Novel Acousto-Optic Liquid Crystal Detector for Full-Field Transmission Ultrasound Breast Imaging

    SciTech Connect

    Rosenfield, J.R.; La Riviere, P.J.; Sandhu, J.S.

    2014-06-15

    Purpose: To characterize the dynamic response of a novel acousto-optic (AO) liquid crystal detector for high-resolution transmission ultrasound breast imaging. Transient and steady-state lesion contrast were investigated to identify optimal transducer settings for our prototype imaging system consistent with the FDA limits of 1 W/cm{sup 2} and 50 J/cm{sup 2} on the incident acoustic intensity and the transmitted acoustic energy flux density. Methods: We have developed a full-field transmission ultrasound breast imaging system that uses monochromatic plane-wave illumination to acquire projection images of the compressed breast. The acoustic intensity transmitted through the breast is converted into a visual image by a proprietary liquid crystal detector operating on the basis of the AO effect. The dynamic response of the AO detector in the absence of an imaged breast was recorded by a CCD camera as a function of the acoustic field intensity and the detector exposure time. Additionally, a stereotactic needle biopsy breast phantom was used to investigate the change in opaque lesion contrast with increasing exposure time for a range of incident acoustic field intensities. Results: Using transducer voltages between 0.3 V and 0.8 V and exposure times of 3 minutes, a unique one-to-one mapping of incident acoustic intensity to steady-state optical brightness in the AO detector was observed. A transfer curve mapping acoustic intensity to steady-state optical brightness shows a high-contrast region analogous to the linear portion of the Hurter-Driffield curves of radiography. Using transducer voltages between 1 V and 1.75 V and exposure times of 90 s, the lesion contrast study demonstrated increasing lesion contrast with increasing breast exposure time and acoustic field intensity. Lesion-to-background contrast on the order of 0.80 was observed. Conclusion: Maximal lesion contrast in our prototype system can be obtained using the highest acoustic field intensity and the

  9. Baroreflex regulation measurement using a noninvasive laser Doppler method

    NASA Astrophysics Data System (ADS)

    Hast, Jukka T.; Myllylae, Risto A.; Sorvoja, Hannu; Nissilae, Seppo M.

    2001-05-01

    In this study, a noninvasive laser Doppler measurement method based on the self-mixing effect of a diode laser was used to measure baroreflex regulation, which is manifest in the blood pressure signal as a 0.1 Hz sinusoidal variation. The laser Doppler measurement system was used to measure the movement of the right radial artery of ten volunteers. Variation in blood pressure caused by the baroreflex affects the elastic properties of the arterial wall. When diastolic blood pressure increases, the elasticity of the arterial wall decreases, causing the wall to lose some of its movability. This decreased elasticity reveals itself in the Doppler signal such that when the blood pressure increases, the Doppler frequency decreases and vice versa. The results show, that the laser Doppler method can be used to measure baroreflex regulation. Finally, baroreflex regulation in the Doppler signal is approximately in the inverse phase with respect to variation in diastolic blood pressure.

  10. Non-intrusive Shock Measurements Using Laser Doppler Vibrometers

    NASA Technical Reports Server (NTRS)

    Statham, Shannon M.; Kolaini, Ali R.

    2012-01-01

    Stud mount accelerometers are widely used by the aerospace industry to measure shock environments during hardware qualification. The commonly used contact-based sensors, however, interfere with the shock waves and distort the acquired signature, which is a concern not actively discussed in the community. To alleviate these interference issues, engineers at the Jet Propulsion Laboratory are investigating the use of non-intrusive sensors, specifically Laser Doppler Vibrometers, as alternatives to the stud mounted accelerometers. This paper will describe shock simulation tests completed at the Jet Propulsion Laboratory, compare the measurements from stud mounted accelerometers and Laser Doppler Vibrometers, and discuss the advantages and disadvantages of introducing Laser Doppler Vibrometers as alternative sensors for measuring shock environments.

  11. Modeling and processing of laser Doppler reactive hyperaemia signals

    NASA Astrophysics Data System (ADS)

    Humeau, Anne; Saumet, Jean-Louis; L'Huiller, Jean-Pierre

    2003-07-01

    Laser Doppler flowmetry is a non-invasive method used in the medical domain to monitor the microvascular blood cell perfusion through tissue. Most commercial laser Doppler flowmeters use an algorithm calculating the first moment of the power spectral density to give the perfusion value. Many clinical applications measure the perfusion after a vascular provocation such as a vascular occlusion. The response obtained is then called reactive hyperaemia. Target pathologies include diabetes, hypertension and peripheral arterial occlusive diseases. In order to have a deeper knowledge on reactive hyperaemia acquired by the laser Doppler technique, the present work first proposes two models (one analytical and one numerical) of the observed phenomenon. Then, a study on the multiple scattering between photons and red blood cells occurring during reactive hyperaemia is carried out. Finally, a signal processing that improves the diagnosis of peripheral arterial occlusive diseases is presented.

  12. Laser Doppler technology applied to atmospheric environmental operating problems

    NASA Technical Reports Server (NTRS)

    Weaver, E. A.; Bilbro, J. W.; Dunkin, J. A.; Jeffreys, H. B.

    1976-01-01

    Carbon dioxide laser Doppler ground wind data were very favorably compared with data from standard anemometers. As a result of these measurements, two breadboard systems were developed for taking research data: a continuous wave velocimeter and a pulsed Doppler system. The scanning continuous wave laser Doppler velocimeter developed for detecting, tracking and measuring aircraft wake vortices was successfully tested at an airport where it located vortices to an accuracy of 3 meters at a range of 150 meters. The airborne pulsed laser Doppler system was developed to detect and measure clear air turbulence (CAT). This system was tested aboard an aircraft, but jet stream CAT was not encountered. However, low altitude turbulence in cumulus clouds near a mountain range was detected by the system and encountered by the aircraft at the predicted time.

  13. Reference beam laser Doppler velocimeter incorporating fiber optic components

    SciTech Connect

    James, S.W.; Lockey, R.A.; Egan, D.; Tatam, R.P.

    1995-12-31

    A compact reference beam laser Doppler velocimeter, constructed using a semiconductor laser diode, optical fiber components and semiconductor detectors, is reported. The device has been designed to overcome many of the problems commonly associated with reference beam configurations. The anemometer may be operated with the laser diode operating in cw and pulsed modes, demonstrating its applicability to wavelength and time division multiplexing schemes for 3D laser Doppler velocimetry. The probe is used to measure the velocity of a spinning disk in the range {minus}20 m/s to +20 m/s.

  14. Non-contact photoacoustic tomography with a laser Doppler vibrometer

    NASA Astrophysics Data System (ADS)

    Xu, Guan; Wang, Cheng; Feng, Ting; Oliver, David E.; Wang, Xueding

    2014-03-01

    Most concurrent photoacoustic tomography systems are based on traditional ultrasound measurement regime, which requires the contact or acoustic coupling material between the biological tissue and the ultrasound transducer. This study investigates the feasibility of non-contact measurement of photacoustic signals generated inside biomedical tissues by observing the vibrations at the surface of the tissues with a commercial laser Doppler vibrometer. The vibrometer with 0- 2MHz measurement bandwidth and 5 MHz sampling frequency was integrated to a conventional rotational PAT data acquisition system. The data acquisition of the vibrometer was synchronized to the laser illumination from an Nd:YAG laser with output at 532nm. The laser energy was tuned to 17.5mJ per square centimeter. The PA signals were acquired at 120 angular locations uniformly distributed around the scanned objects. The frequency response of the measurement system was first calibrated. 2-inch-diamater cylindrical phantoms containing small rubber plates and biological tissues were afterwards imaged. The phantoms were made from 5% intralipid solution in 10% porcine gelatin to simulate the light scattering in biological tissue and to backscatter the measurement laser from the vibrometer. Time-domain backprojection method was used for the image reconstruction. Experiments with real-tissue phantoms show that with laser illumination of 17.5 mJ/cm2 at 532 nm, the non-contact photoacoustic (PA) imaging system with 15dB detection bandwidth of 2.5 MHz can resolve spherical optical inclusions with dimension of 500μm and multi-layered structure with optical contrast in strongly scattering medium. The experiment results prompt the potential implementation of the non-contact PAT to achieve "photoacoustic camera".

  15. Three-dimensional shear wave imaging based on full-field laser speckle contrast imaging with one-dimensional mechanical scanning.

    PubMed

    Chao, Pei-Yu; Li, Pai-Chi

    2016-08-22

    The high imaging resolution and motion sensitivity of optical-based shear wave detection has made it an attractive technique in biomechanics studies with potential for improving the capabilities of shear wave elasticity imaging. In this study we implemented laser speckle contrast imaging for two-dimensional (X-Z) tracking of transient shear wave propagation in agarose phantoms. The mechanical disturbances induced by the propagation of the shear wave caused temporal and spatial fluctuations in the local speckle pattern, which manifested as local blurring. By mechanically moving the sample in the third dimension (Y), and performing two-dimensional shear wave imaging at every scan position, the three-dimensional shear wave velocity distribution of the phantom could be reconstructed. Based on comparisons with the reference shear wave velocity measurements obtained using a commercial ultrasound shear wave imaging system, the developed system can estimate the shear wave velocity with an error of less than 6% for homogeneous phantoms with shear moduli ranging from 1.52 kPa to 7.99 kPa. The imaging sensitivity of our system makes it capable of measuring small variations in shear modulus; the estimated standard deviation of the shear modulus was found to be less than 0.07 kPa. A submillimeter spatial resolution for three-dimensional shear wave imaging has been achieved, as demonstrated by the ability to detect a 1-mm-thick stiff plate embedded inside heterogeneous agarose phantoms. PMID:27557169

  16. Paraxial Full-Field Cloaking

    NASA Astrophysics Data System (ADS)

    Choi, Joseph; Howell, John

    2015-05-01

    Broadband, omnidirectional invisibility cloaking has been a goal of scientists since coordinate transformations were suggested for cloaking. The requirements for realizing such a cloak can be simplified by considering only the paraxial (`small-angle') regime. We recap the experimental demonstration of paraxial ray optics cloaking and theoretically complete its formalism, by extending it to the full-field of light. We then show how to build a full-field paraxial cloaking system.

  17. Early experience in the use of quantitative image quality measurements for the quality assurance of full field digital mammography x-ray systems.

    PubMed

    Marshall, N W

    2007-09-21

    Quantitative image quality results in the form of the modulation transfer function (MTF), normalized noise power spectrum (NNPS) and detective quantum efficiency (DQE) are presented for nine full field digital mammography (FFDM) systems. These parameters are routinely measured as part of the quality assurance (QA) programme for the seven FFDM units covered by our centre. Just one additional image is required compared to the standard FFDM protocol; this is the image of an edge, from which the MTF is calculated. A variance image is formed from one of the flood images used to measure the detector response and this provides useful information on the condition of the detector with respect to artefacts. Finally, the NNPS is calculated from the flood image acquired at a target detector air kerma (DAK) of 100 microGy. DQE is then estimated from these data; however, no correction is currently made for effects of detector cover transmission on DQE. The coefficient of variation (cov) of the 50% point of the MTF for five successive MTF results was 1%, while the cov for the 50% MTF point for an a-Se system over a period of 17 months was approximately 3%. For four a-Se based systems, the cov for the NNPS at 1 mm(-1) for a target DAK of 100 microGy was approximately 4%; the same result was found for four CsI based FFDM units. With regard to the stability of NNPS over time, the cov for four NNPS results acquired over a period of 12 months was also approximately 4%. The effect of acquisition geometry on NNPS was also assessed for a CsI based system. NNPS data acquired with the antiscatter grid in place showed increased noise at low spatial frequency; this effect was more severe as DAK increased. DQE results for the three detector types (a-Se, CsI and CR) are presented as a function of DAK. Some reduction in DQE was found for both the a-Se and CsI based systems at a target DAK of 12.5 microGy when compared to DQE data acquired at 100 microGy. For the CsI based systems, DQE at 1 mm

  18. Early experience in the use of quantitative image quality measurements for the quality assurance of full field digital mammography x-ray systems

    NASA Astrophysics Data System (ADS)

    Marshall, N. W.

    2007-09-01

    Quantitative image quality results in the form of the modulation transfer function (MTF), normalized noise power spectrum (NNPS) and detective quantum efficiency (DQE) are presented for nine full field digital mammography (FFDM) systems. These parameters are routinely measured as part of the quality assurance (QA) programme for the seven FFDM units covered by our centre. Just one additional image is required compared to the standard FFDM protocol; this is the image of an edge, from which the MTF is calculated. A variance image is formed from one of the flood images used to measure the detector response and this provides useful information on the condition of the detector with respect to artefacts. Finally, the NNPS is calculated from the flood image acquired at a target detector air kerma (DAK) of 100 µGy. DQE is then estimated from these data; however, no correction is currently made for effects of detector cover transmission on DQE. The coefficient of variation (cov) of the 50% point of the MTF for five successive MTF results was 1%, while the cov for the 50% MTF point for an a-Se system over a period of 17 months was approximately 3%. For four a-Se based systems, the cov for the NNPS at 1 mm-1 for a target DAK of 100 µGy was approximately 4%; the same result was found for four CsI based FFDM units. With regard to the stability of NNPS over time, the cov for four NNPS results acquired over a period of 12 months was also approximately 4%. The effect of acquisition geometry on NNPS was also assessed for a CsI based system. NNPS data acquired with the antiscatter grid in place showed increased noise at low spatial frequency; this effect was more severe as DAK increased. DQE results for the three detector types (a-Se, CsI and CR) are presented as a function of DAK. Some reduction in DQE was found for both the a-Se and CsI based systems at a target DAK of 12.5 µGy when compared to DQE data acquired at 100 µGy. For the CsI based systems, DQE at 1 mm-1 fell from 0

  19. Dual beam translator for use in Laser Doppler anemometry

    DOEpatents

    Brudnoy, David M.

    1987-01-01

    A method and apparatus for selectively translating the path of at least one pair of light beams in a Laser Doppler anemometry device whereby the light paths are translated in a direction parallel to the original beam paths so as to enable attainment of spacial coincidence of the two intersection volumes and permit accurate measurements of Reynolds shear stress.

  20. Dual beam translator for use in Laser Doppler anemometry

    DOEpatents

    Brudnoy, D.M.

    1984-04-12

    A method and apparatus for selectively translating the path of at least one pair of light beams in a Laser Doppler anemometry device whereby the light paths are translated in a direction parallel to the original beam paths so as to enable attainment of spacial coincidence of the two intersection volumes and permit accurate measurements of Reynolds shear stress.

  1. Remote measurement of wind speed by laser Doppler systems.

    PubMed

    Hughes, A J; Pike, E R

    1973-03-01

    Several types of laser Doppler velocimeter are considered for remote measurement of wind velocity. Particular attention is given to the range dependence of the mean power SNR when scattering is from natural aerosols. Numerical estimates for two systems are presented, indicating that CO(2) laser systems have considerably greater sensitivity than visible laser systems at ranges greater than a few meters.

  2. Wing tip vortex measurements with laser Doppler systems

    NASA Technical Reports Server (NTRS)

    Fuller, C. E., III

    1973-01-01

    The vortex velocity field produced by a rectangular wing in a subsonic wind tunnel was measured using two laser Doppler velocimeter systems. One system made three dimensional mean velocity measurements and the other made one dimensional turbulence measurements. The systems and test procedures are described and comparisons of the measurements are made. The data defined a strong spiral motion in the vortex formation process.

  3. Anomaly Detection In Additively Manufactured Parts Using Laser Doppler Vibrometery

    SciTech Connect

    Hernandez, Carlos A.

    2015-09-29

    Additively manufactured parts are susceptible to non-uniform structure caused by the unique manufacturing process. This can lead to structural weakness or catastrophic failure. Using laser Doppler vibrometry and frequency response analysis, non-contact detection of anomalies in additively manufactured parts may be possible. Preliminary tests show promise for small scale detection, but more future work is necessary.

  4. Review of methodological developments in laser Doppler flowmetry.

    PubMed

    Rajan, Vinayakrishnan; Varghese, Babu; van Leeuwen, Ton G; Steenbergen, Wiendelt

    2009-03-01

    Laser Doppler flowmetry is a non-invasive method of measuring microcirculatory blood flow in tissue. In this review the technique is discussed in detail. The theoretical and experimental developments to improve the technique are reviewed. The limitations of the method are elaborated upon, and the research done so far to overcome these limitations is critically assessed.

  5. Laser Doppler visualisation of the velocity field by excluding the influence of multiparticle scattering

    SciTech Connect

    Dubnishchev, Yu N; Chugui, Yu V; Kompenhans, J

    2009-10-31

    The method of laser Doppler visualisation and measurement of the velocity field in gas and liquid flows by suppressing the influence of multiparticle scattering is discussed. The cross section of the flow under study is illuminated by a laser beam transformed by an anamorphic optical system into a laser sheet. The effect of multiparticle scattering is eliminated by obtaining differential combinations of frequency-demodulated images of the laser sheet in different regions of the angular spectrum of scattered light. (laser applications and other topics in quantum electronics)

  6. All semiconductor laser Doppler anemometer at 1.55 microm.

    PubMed

    Hansen, René Skov; Pedersen, Christian

    2008-10-27

    We report to our best knowledge the first all semiconductor Laser Doppler Anemometer (LIDAR) for wind speed determination. We will present the design and first experimental results on a focusing coherent cw laser Doppler anemometer for measuring atmospheric wind velocities in the 10 meters to 300 meters distance range. Especially, we will demonstrate that both the output power as well as the demanding coherence properties required from the laser source can be accomplished by an all semiconductor laser. Preliminary tests at a distance of 40 meters indicate a typical signal to noise ratio of 9 dB. This result is obtained at a clear day with an up-date rate of 12 Hz.

  7. All semiconductor laser Doppler anemometer at 1.55 microm.

    PubMed

    Hansen, René Skov; Pedersen, Christian

    2008-10-27

    We report to our best knowledge the first all semiconductor Laser Doppler Anemometer (LIDAR) for wind speed determination. We will present the design and first experimental results on a focusing coherent cw laser Doppler anemometer for measuring atmospheric wind velocities in the 10 meters to 300 meters distance range. Especially, we will demonstrate that both the output power as well as the demanding coherence properties required from the laser source can be accomplished by an all semiconductor laser. Preliminary tests at a distance of 40 meters indicate a typical signal to noise ratio of 9 dB. This result is obtained at a clear day with an up-date rate of 12 Hz. PMID:18958105

  8. Scanning laser Doppler vibrometry of the middle ear ossicles.

    PubMed

    Ball, G R; Huber, A; Goode, R L

    1997-04-01

    This paper describes measurements of the vibratory modes of the middle ear ossicles made with a scanning laser Doppler vibrometer. Previous studies of the middle ear ossicles with single-point laser Doppler measurements have raised questions regarding the vibrational modes of the ossicular chain. Single-point analysis methods do not have the ability to measure multiple points on the ossicles and, consequently, have limited ability to simultaneously record relative phase information at these points. Using a Polytec Model PSV-100, detailed measurements of the ossicular chain have been completed in the human temporal bone model. This model, when driven with a middle ear transducer, provides detailed three-dimensional data of the vibrational patterns of the middle ear ossicles. Implications for middle ear implantable devices are discussed.

  9. Evaluation of skin vasomotor reflexes by using laser Doppler velocimetry.

    PubMed

    Low, P A; Neumann, C; Dyck, P J; Fealey, R D; Tuck, R R

    1983-09-01

    We used a laser Doppler velocimeter for measurement of skin blood flow in 63 healthy control subjects and in patients with dysautonomias. We measured vasoconstrictor responses to inspiratory gasp, standing, Valsalva maneuver, and cold stimulus. An abnormal profile was defined in terms of the percentage of abnormal test results, the results of individual tests, and the alterations in the shape of the recorded response. These measurements of vasomotor function may permit the diagnosis of focal abnormalities of peripheral nerve sympathetic failure. PMID:6310277

  10. Laser Doppler flowmetry in diagnoses of chronic tonsillitis

    NASA Astrophysics Data System (ADS)

    Mareew, Gleb O.; Mareew, Oleg V.; Maslyakova, Galina N.; Ivliev, Igor I.; Fedosov, Ivan V.; Lychagov, Vladislav V.; Tuchin, Valery V.

    2005-06-01

    Chronic tonsillitis is one of the most common diseases in ENT all over the world. There are two ways of treatment-surgical tonsillectomy and conservative therapeutically treatment. But still doctors have no possibility to make objective decisions for this painful and tonsil-destructive operation. In this article we try to research how the degree of sclerosis in tonsillar tissue affects the blood flow in tonsils, by using laser Doppler flowmetry.

  11. New signal analysis methods for laser doppler flowmetric recordings

    NASA Astrophysics Data System (ADS)

    ǎgǎnescu, G. E., Dr; Todea, Carmen

    2014-01-01

    The laser Doppler flowmetry devices give a series of information like the blood flux and some statistical parameters, automatically estimated. There are also new important attempts based on the Fourier transform of the flow flux signal which gather more information from the laser Doppler flowmetry. The amplitude spectra estimated in these articles, exhibit a series of peaks corresponding to the cardiac variation of the blood flow and noise components of the flow flux signals, dependent on the state of the tooth. The aim of our investigations is to introduce new signal processing methods, based on wavelet continuous tranform, which express in a more sensitive manner the modifications of the flow flux signal with the state of the tooth, and to introduce new quantitative parameters, defined in a previous paper. These parameters express, in a more sensitive manner the modifications of the pulp flow flux signal in relation with the pulp tooth healt, and to introduce new quantitative parameters, defined in a previous paper. These parameters express, in a sensitive way the changes of the blood flux. For practical investigations we used a series of signals recorded with the aid of a Laser Doppler Blood Flow Monitoring device (Moor Instruments) and processed with the computer.

  12. Laser Doppler vibration testing: Final report. [Under difficult conditions

    SciTech Connect

    Assa, A.S.; Mannara, S.R.

    1987-05-01

    This report summarizes work under EPRI project RP1855-2 conducted toward the objective of developing utility applications for a noncontacting laser Doppler vibration (LDV) measurement instrument. As part of the program, a dual beam laser doppler system was designed and fabricated in-house for the measurement of torsional vibrations of shafts. Laboratory tests were performed with this instrument to evaluate various signal processing approaches, and characterize the LDV performance with different laser powers and on several surface roughnesses. A factory test simulating field conditions was conducted on a full-size large steam turbine-generator rotor. The test was successful with the accuracy and linearity of the laser system within 10% of a reference measurement. Following the work on the dual beam system, work was directed toward field test evaluations of a portable reference beam laser doppler vibrometer. A main objective was to see if the LDV could perform satisfactorily under the rigors of a utility environment. Successful vibration measurements were taken on turbine steam leads at 1000/sup 0/F (without requiring unit shutdown), on heat exchanger tubes inside an operating boiler, from a rotating shaft, and from a black carbon collector brush at 500 volts. In the final test at United Illuminating Co., vibration data were obtained without unit shutdown from the generator neutral isophase bus lines with 13,000 amps of current in the line.

  13. Full-field OCT: applications in ophthalmology

    NASA Astrophysics Data System (ADS)

    Grieve, Kate; Dubois, Arnaud; Paques, Michel; Le Gargasson, Jean-Francois; Boccara, Albert C.

    2005-04-01

    We present images of ocular tissues obtained using ultrahigh resolution full-field OCT. The experimental setup is based on the Linnik interferometer, illuminated by a tungsten halogen lamp. En face tomographic images are obtained in real-time without scanning by computing the difference of two phase-opposed interferometric images recorded by a high-resolution CCD camera. A spatial resolution of 0.7 μm × 0.9 μm (axial × transverse) is achieved thanks to the short source coherence length and the use of high numerical aperture microscope objectives. A detection sensitivity of 90 dB is obtained by means of image averaging and pixel binning. Whole unfixed eyes and unstained tissue samples (cornea, lens, retina, choroid and sclera) of ex vivo rat, mouse, rabbit and porcine ocular tissues were examined. The unprecedented resolution of our instrument allows cellular-level resolution in the cornea and retina, and visualization of individual fibers in the lens. Transcorneal lens imaging was possible in all animals, and in albino animals, transscleral retinal imaging was achieved. We also introduce our rapid acquisition full-field optical coherence tomography system designed to accommodate in vivo ophthalmologic imaging. The variations on the original system technology include the introduction of a xenon arc lamp as source, and rapid image acquisition performed by a high-speed CMOS camera, reducing acquisition time to 5 ms per frame.

  14. Surface Charge Measurement of SonoVue, Definity and Optison: A Comparison of Laser Doppler Electrophoresis and Micro-Electrophoresis.

    PubMed

    Ja'afar, Fairuzeta; Leow, Chee Hau; Garbin, Valeria; Sennoga, Charles A; Tang, Meng-Xing; Seddon, John M

    2015-11-01

    Microbubble (MB) contrast-enhanced ultrasonography is a promising tool for targeted molecular imaging. It is important to determine the MB surface charge accurately as it affects the MB interactions with cell membranes. In this article, we report the surface charge measurement of SonoVue, Definity and Optison. We compare the performance of the widely used laser Doppler electrophoresis with an in-house micro-electrophoresis system. By optically tracking MB electrophoretic velocity in a microchannel, we determined the zeta potentials of MB samples. Using micro-electrophoresis, we obtained zeta potential values for SonoVue, Definity and Optison of -28.3, -4.2 and -9.5 mV, with relative standard deviations of 5%, 48% and 8%, respectively. In comparison, laser Doppler electrophoresis gave -8.7, +0.7 and +15.8 mV with relative standard deviations of 330%, 29,000% and 130%, respectively. We found that the reliability of laser Doppler electrophoresis is compromised by MB buoyancy. Micro-electrophoresis determined zeta potential values with a 10-fold improvement in relative standard deviation.

  15. Catadioptric Optics for laser Doppler velocimeter applications

    NASA Technical Reports Server (NTRS)

    Dunagan, Stephen E.

    1989-01-01

    In the design of a laser velocimeter system, attention must be given to the performance of the optical elements in their two principal tasks: focusing laser radiation into the probe volume, and collecting the scattered light. For large aperture applications, custom lens design and fabrication costs, long optical path requirements, and chromatic aberration (for two color operation) can be problematic. The adaptation of low cost Schmidt-Cassegrain astronomical telescopes to perform these laser beam manipulation and scattered light collection tasks is examined. A generic telescope design is analyzed using ray tracing and Gaussian beam propagation theory, and a simple modification procedure for converting from infinite to near unity conjugate ratio operation with image quality near the diffraction limit was identified. Modification requirements and performance are predicted for a range of geometries. Finally, a 200-mm-aperture telescope was modified for f/10 operation; performance data for this modified optic for both laser beam focusing and scattered light collection tasks agree well with predictions.

  16. Estimation of breast percent density in raw and processed full field digital mammography images via adaptive fuzzy c-means clustering and support vector machine segmentation

    SciTech Connect

    Keller, Brad M.; Nathan, Diane L.; Wang Yan; Zheng Yuanjie; Gee, James C.; Conant, Emily F.; Kontos, Despina

    2012-08-15

    Purpose: The amount of fibroglandular tissue content in the breast as estimated mammographically, commonly referred to as breast percent density (PD%), is one of the most significant risk factors for developing breast cancer. Approaches to quantify breast density commonly focus on either semiautomated methods or visual assessment, both of which are highly subjective. Furthermore, most studies published to date investigating computer-aided assessment of breast PD% have been performed using digitized screen-film mammograms, while digital mammography is increasingly replacing screen-film mammography in breast cancer screening protocols. Digital mammography imaging generates two types of images for analysis, raw (i.e., 'FOR PROCESSING') and vendor postprocessed (i.e., 'FOR PRESENTATION'), of which postprocessed images are commonly used in clinical practice. Development of an algorithm which effectively estimates breast PD% in both raw and postprocessed digital mammography images would be beneficial in terms of direct clinical application and retrospective analysis. Methods: This work proposes a new algorithm for fully automated quantification of breast PD% based on adaptive multiclass fuzzy c-means (FCM) clustering and support vector machine (SVM) classification, optimized for the imaging characteristics of both raw and processed digital mammography images as well as for individual patient and image characteristics. Our algorithm first delineates the breast region within the mammogram via an automated thresholding scheme to identify background air followed by a straight line Hough transform to extract the pectoral muscle region. The algorithm then applies adaptive FCM clustering based on an optimal number of clusters derived from image properties of the specific mammogram to subdivide the breast into regions of similar gray-level intensity. Finally, a SVM classifier is trained to identify which clusters within the breast tissue are likely fibroglandular, which are then

  17. Development of in-situ full-field spectroscopic imaging analysis and application on Li-ion battery using transmission x-ray microscopy

    NASA Astrophysics Data System (ADS)

    Chen-Wiegart, Yu-chen K.; Wang, Jiajun; Wang, Jun

    2013-09-01

    This paper presents the advance in spectroscopic imaging technique and analysis method from the newly developed transmission x-ray microscopy (TXM) at the beamline X8C of National Synchrotron Light Source. Through leastsquares linear combination fitting we developed on the in situ spectroscopic images, a time-dependent and spatially resolved chemical composition mapping can be obtained and quantitatively analyzed undergone chemical/electrochemical reactions. A correlation of morphological evolution, chemical state distribution changes and reaction conditions can be revealed. We successfully applied this method to study the electrochemical evolution of CuO, an anode material of Li-ion battery, during the lithiation-delitiation cycling.

  18. Spinning disk calibration method and apparatus for laser Doppler velocimeter

    NASA Technical Reports Server (NTRS)

    Snyder, P. K. (Inventor)

    1986-01-01

    A method and apparatus for calibrating laser Doppler velocimeters having one or more intersecting beam pairs are described. These velocimeters measure fluid velocity by observing the light scattered by particles in the fluid stream. Moving fluid particulates are simulated by fine taut wires that are radially mounted on a disk that is rotated at a known velocity. The laser beam intersection locus is first aimed at the very center of the disk and then the disk is translated so that the locus is swept by the rotating wires. The radial distance traversed is precisely measured so that the velocity of the wires (pseudo particles) may be calculated.

  19. Laser Doppler Vibrometry measurement of the mechanical myogram

    NASA Astrophysics Data System (ADS)

    Rohrbaugh, John W.; Sirevaag, Erik J.; Richter, Edward J.

    2012-06-01

    Contracting muscles show complex dimensional changes that include lateral expansion. Because this expansion process is intrinsically vibrational, driven by repetitive actions of multiple motor units, it can be sensed and quantified using the method of Laser Doppler Vibrometry (LDV). LDV has a number of advantages over more traditional mechanical methods based on microphones and accelerometers. The LDV mechanical myogram from a small hand muscle was shown under conditions of elastic loading to be related systematically to the level of force production, and to compare favorably with conventional methods for sensing the mechanical and electrical aspects of muscle contraction.

  20. Compact laser Doppler flowmeter for application in dentistry

    NASA Astrophysics Data System (ADS)

    Fedosov, Ivan V.; Mareew, Gleb O.; Finokhina, Olga A.; Lepilin, Alexander V.; Tuchin, Valery V.

    2005-06-01

    Lightweight handheld laser Doppler instrument is designed for blood flow assessment in soft tissues of oral cavity. Laser light source, fiber optic probe detector and amplifier circuitry are mounted inside the compact hand held probe assembly to minimize noise and to exclude optical fiber motion artifacts. Both the instrument and data processing software are optimized for the using of the standard PC sound interface as the data acquisition device that provides low cost and effective solution for clinical use. The instrument is suitable for quantitative diagnostics of gingivitis and other disorders in dentistry.

  1. Compensation for refractive-index variations in laser Doppler anemometry.

    PubMed

    Kehoe, A B; Desai, P V

    1987-07-01

    Techniques to compensate for index of refraction variations in the application of a laser Doppler anemometer are examined. For discontinuous plane-layered media a method of discrete elements is employed. An alternative set of equations is derived for continuous cylindrically layered media and simplified to make comparisons with available results for a single cylinder. Results of velocity measurements in a Plexiglas model of a cylindrically layered nuclear fuel assembly are presented to establish a positioning accuracy of the method to within 0.025 cm. PMID:20489924

  2. Compensation for refractive-index variations in laser Doppler anemometry.

    PubMed

    Kehoe, A B; Desai, P V

    1987-07-01

    Techniques to compensate for index of refraction variations in the application of a laser Doppler anemometer are examined. For discontinuous plane-layered media a method of discrete elements is employed. An alternative set of equations is derived for continuous cylindrically layered media and simplified to make comparisons with available results for a single cylinder. Results of velocity measurements in a Plexiglas model of a cylindrically layered nuclear fuel assembly are presented to establish a positioning accuracy of the method to within 0.025 cm.

  3. Effect of intracapsular hyperpressure on femoral head blood flow. Laser Doppler flowmetry in dogs.

    PubMed

    Vegter, J; Klopper, P J

    1991-08-01

    Intracapsular hyperpressure in the hip joint of dogs affected femoral head blood flow, especially in the juvenile animals. Graphic recording of the laser Doppler signal curve using rapid sampling time demonstrated venous hip joint tamponade in both juvenile and adult dogs. Laser Doppler flowmetry seems to be a sensitive and reproducible method to demonstrate femoral-head blood-flow changes.

  4. Laser Doppler velocity measurements of swirling flows with upstream influence

    NASA Technical Reports Server (NTRS)

    Rloff, K. L.; Bossel, H. H.

    1973-01-01

    Swirling flow in a rotating tube is studied by flow visualization at a moderate Reynolds number, and its velocity field is measured by laser-Doppler anemometry. The tube has constant diameter, and approximately uniform initial rigid rotation of the flow is assured by passing the flow through a rotating plug of porous metal before it enters the test section. At moderate swirl values, an object mounted on the tube centerline causes a closed bubble to form upstream of the obstacle, with a clearly defined stagnation point on the axis, and recirculating flow inside the bubble. The bubble length grows upstream as the swirl is increased, until it breaks up into a Taylor column reaching all the way upstream and downstream at swirl values above a certain critical value. A vortex jump (in the sense of Benjamin) occurs downstream of the obstacle except when the Taylor column is present. Using a laser-Doppler anemometer, axial and swirl velocity profiles are obtained at several stations upstream and downstream of the bubble, and in and around the bubble.

  5. Evaluation of gingival vascularisation using laser Doppler flowmetry

    NASA Astrophysics Data System (ADS)

    Vitez, B.; Todea, C.; Velescu, A.; Şipoş, C.

    2016-03-01

    Aim: The present study aims to assess the level of vascularisation of the lower frontal gingiva of smoker patients, in comparison with non-smokers by using Laser Doppler Flowmetry (LDF), in order to determine the changes in gingival microcirculation. Material & methods: 16 volunteers were included in this study and separated into 2 equal groups: non-smoker subjects in Group I and smoker subjects in Group II. All patients were submitted to a visual examination and professional cleaning The gingival bloodflow of each patient was recorded in 5 zones using LDF, resulting in a total of 80 recordings. LDF was done with the Moor Instruments Ltd. "moorLAB" Laser Doppler. All data were collected as graphs, raw values and statistically analyzed. Results: After strict analysis results show that Group II presents a steady level of gingival microcirculation with even patterns in the graph, while Group I shows many signs of damage to it`s microvascular system through many irregularities in the microcirculation level and graph patterns. Conclusion: The results suggest that prolonged smoking has a definitive effect on the gingival vascularisation making it a key factor in periodontal pathology.

  6. Wavelet analysis of the Laser Doppler signal to assess skin perfusion.

    PubMed

    Bagno, Andrea; Martini, Romeo

    2015-01-01

    The hemodynamics of skin microcirculation can be clinically assessed by means of Laser Doppler Fluxmetry. Laser Doppler signals show periodic oscillations because of fluctuations of microvascular perfusion (flowmotion), which are sustained by contractions and relaxations of arteriolar walls rhythmically changing vessels diameter (vasomotion). The wavelet analysis applied to Laser Doppler signals displays six characteristic frequency intervals, from 0.005 to 2 Hz. Each interval is assigned to a specific structure of the cardiovascular system: heart, respiration, vascular myocites, sympathetic terminations, and endothelial cells (dependent and independent on nitric oxide). Therefore, mechanisms of skin perfusion can be investigated through wavelet analysis. In the present work, examples of methods and results of wavelet analysis applied to Laser Doppler signals are reported. Laser Doppler signals were acquired in two groups of patients to check possible changes in vascular activities, before and after occlusive reactive hyperaemia, and before and after revascularization.

  7. Accurate and precise calibration of AFM cantilever spring constants using laser Doppler vibrometry.

    PubMed

    Gates, Richard S; Pratt, Jon R

    2012-09-21

    Accurate cantilever spring constants are important in atomic force microscopy both in control of sensitive imaging and to provide correct nanomechanical property measurements. Conventional atomic force microscope (AFM) spring constant calibration techniques are usually performed in an AFM. They rely on significant handling and often require touching the cantilever probe tip to a surface to calibrate the optical lever sensitivity of the configuration. This can damage the tip. The thermal calibration technique developed for laser Doppler vibrometry (LDV) can be used to calibrate cantilevers without handling or touching the tip to a surface. Both flexural and torsional spring constants can be measured. Using both Euler-Bernoulli modeling and an SI traceable electrostatic force balance technique as a comparison we demonstrate that the LDV thermal technique is capable of providing rapid calibrations with a combination of ease, accuracy and precision beyond anything previously available.

  8. Cantilever spring constant calibration using laser Doppler vibrometry.

    PubMed

    Ohler, Benjamin

    2007-06-01

    Uncertainty in cantilever spring constants is a critical issue in atomic force microscopy (AFM) force measurements. Though numerous methods exist for calibrating cantilever spring constants, the accuracy of these methods can be limited by both the physical models themselves as well as uncertainties in their experimental implementation. Here we report the results from two of the most common calibration methods, the thermal tune method and the Sader method. These were implemented on a standard AFM system as well as using laser Doppler vibrometry (LDV). Using LDV eliminates some uncertainties associated with optical lever detection on an AFM. It also offers considerably higher signal to noise deflection measurements. We find that AFM and LDV result in similar uncertainty in the calibrated spring constants, about 5%, using either the thermal tune or Sader methods provided that certain limitations of the methods and instrumentation are observed.

  9. Application of laser Doppler velocimeter to chemical vapor laser system

    NASA Technical Reports Server (NTRS)

    Gartrell, Luther R.; Hunter, William W., Jr.; Lee, Ja H.; Fletcher, Mark T.; Tabibi, Bagher M.

    1993-01-01

    A laser Doppler velocimeter (LDV) system was used to measure iodide vapor flow fields inside two different-sized tubes. Typical velocity profiles across the laser tubes were obtained with an estimated +/-1 percent bias and +/-0.3 to 0.5 percent random uncertainty in the mean values and +/-2.5 percent random uncertainty in the turbulence-intensity values. Centerline velocities and turbulence intensities for various longitudinal locations ranged from 13 to 17.5 m/sec and 6 to 20 percent, respectively. In view of these findings, the effects of turbulence should be considered for flow field modeling. The LDV system provided calibration data for pressure and mass flow systems used routinely to monitor the research laser gas flow velocity.

  10. Cantilever spring constant calibration using laser Doppler vibrometry

    SciTech Connect

    Ohler, Benjamin

    2007-06-15

    Uncertainty in cantilever spring constants is a critical issue in atomic force microscopy (AFM) force measurements. Though numerous methods exist for calibrating cantilever spring constants, the accuracy of these methods can be limited by both the physical models themselves as well as uncertainties in their experimental implementation. Here we report the results from two of the most common calibration methods, the thermal tune method and the Sader method. These were implemented on a standard AFM system as well as using laser Doppler vibrometry (LDV). Using LDV eliminates some uncertainties associated with optical lever detection on an AFM. It also offers considerably higher signal to noise deflection measurements. We find that AFM and LDV result in similar uncertainty in the calibrated spring constants, about 5%, using either the thermal tune or Sader methods provided that certain limitations of the methods and instrumentation are observed.

  11. Laser Doppler vibrometry measurement of the mechanical myogram.

    PubMed

    Rohrbaugh, John W; Sirevaag, Erik J; Richter, Edward J

    2013-12-01

    Contracting muscles show complex dimensional changes that include lateral expansion. Because this expansion process is intrinsically vibrational, driven by repetitive actions of multiple motor units, it can be sensed and quantified using the method of Laser Doppler Vibrometry (LDV). LDV has a number of advantages over more traditional mechanical methods based on microphones and accelerometers. The LDV mechanical myogram from a small hand muscle (the first dorsal interosseous) was studied under conditions of elastic loading applied to the tip of the abducted index finger. The LDV signal was shown to be related systematically to the level of force production, and to compare favorably with conventional methods for sensing the mechanical and electrical aspects of muscle contraction.

  12. Application of Laser Doppler Vibrometery for human heart auscultation.

    PubMed

    Koegelenberg, S; Scheffer, C; Blanckenberg, M M; Doubell, A F

    2014-01-01

    In this study the potential of a Laser Doppler Vibrometer (LDV) was tested as a non-contact sensor for the classification of heart sounds. Of the twenty participants recorded using the LDV, five presented with Aortic Stenosis (AS), three were healthy and twelve presented with other pathologies. The recorded heart sounds were denoised and segmented using a combination of the Electrocardiogram (ECG) data and the complexity of the signal. Frequency domain features were extracted from the segmented heart sound cycles and used to train a K-nearest neighbor classifier. Due to the small number of participants, the classifier could not be trained to differentiate between normal and abnormal participants, but could successfully distinguish between participants who presented with AS and those who did not. A sensitivity of 80 % and a specificity of 100 % were achieved a test dataset.

  13. Spatially encoded multibeam laser Doppler vibrometry using a single photodetector.

    PubMed

    Fu, Y; Guo, M; Phua, P B

    2010-05-01

    A laser Doppler vibrometer with single photodetector is introduced to measure the vibration on multiple points of target simultaneously. A 2 x 5 beam array with various frequency shifts is generated by three acousto-optic devices, illuminating different points on a vibrating object. The reflected beams interfere with a reference beam on a high-speed photodetector, and the signal is amplified and digitized with a rate of 500 megasamples/s. To extract vibration information of different points, the carrier frequencies of each beam are elaborately designed so that they can be separated from cross-talk regions in the spectrum. The experimental results are compared with that from a commercial single-point vibrometer, and the comparison shows that it is possible to do a precise measurement on multiple points simultaneously using a single photodetector.

  14. Holographic optical system for aberration corrections in laser Doppler velocimetry

    NASA Technical Reports Server (NTRS)

    Kim, R. C.; Case, S. K.; Schock, H. J.

    1985-01-01

    An optical system containing multifaceted holographic optical elements (HOEs) has been developed to correct for aberrations introduced by nonflat windows in laser Doppler velocimetry. The multifacet aberration correction approach makes it possible to record on one plate many sets of adjacent HOEs that address different measurement volume locations. By using 5-mm-diameter facets, it is practical to place 10-20 sets of holograms on one 10 x 12.5-cm plate, so that the procedure of moving the entire optical system to examine different locations may not be necessary. The holograms are recorded in dichromated gelatin and therefore are nonabsorptive and suitable for use with high-power argon laser beams. Low f-number optics coupled with a 90-percent efficient distortion-correcting hologram in the collection side of the system yield high optical efficiency.

  15. Laser Doppler vibrometry measurement of the mechanical myogram

    NASA Astrophysics Data System (ADS)

    Rohrbaugh, John W.; Sirevaag, Erik J.; Richter, Edward J.

    2013-12-01

    Contracting muscles show complex dimensional changes that include lateral expansion. Because this expansion process is intrinsically vibrational, driven by repetitive actions of multiple motor units, it can be sensed and quantified using the method of Laser Doppler Vibrometry (LDV). LDV has a number of advantages over more traditional mechanical methods based on microphones and accelerometers. The LDV mechanical myogram from a small hand muscle (the first dorsal interosseous) was studied under conditions of elastic loading applied to the tip of the abducted index finger. The LDV signal was shown to be related systematically to the level of force production, and to compare favorably with conventional methods for sensing the mechanical and electrical aspects of muscle contraction.

  16. Laser Doppler velocimetry using a modified computer mouse

    NASA Astrophysics Data System (ADS)

    Zaron, Edward D.

    2016-10-01

    A computer mouse has been modified for use as a low-cost laser Doppler interferometer and used to measure the two-component fluid velocity of a flowing soap film. The mouse sensor contains two vertical cavity surface emitting lasers, photodiodes, and signal processing hardware integrated into a single package, approximately 1 cm2 in size, and interfaces to a host computer via a standard USB port. Using the principle of self-mixing interferometry, whereby laser light re-enters the laser cavity after being scattered from a moving target, the Doppler shift and velocity of scatterers dispersed in the flow are measured. Observations of the boundary layer in a turbulent soap film channel flow demonstrate the capabilities of the sensor.

  17. Fiber-optic laser Doppler turbine tip clearance probe.

    PubMed

    Büttner, Lars; Pfister, Thorsten; Czarske, Jürgen

    2006-05-01

    A laser Doppler based method for in situ single blade tip clearance measurements of turbomachines with high precision is presented for what we believe is the first time. The sensor is based on two superposed fanlike interference fringe systems generated by two laser wavelengths from a fiber-coupled, passive, and therefore compact measurement head employing diffractive optics. Tip clearance measurements at a transonic centrifugal compressor performed during operation at 50,000 rpm (833 Hz, 586 m/s tip speed) are reported. At these speeds the measured uncertainty of the tip position was less than 20 microm, a factor of 2 more accurate than that of capacitive probes. The sensor offers great potential for in situ and online high-precision tip clearance measurements of metallic and nonmetallic turbine blades. PMID:16642064

  18. Motion of tympanic membrane in guinea pig otitis media model measured by scanning laser Doppler vibrometry.

    PubMed

    Wang, Xuelin; Guan, Xiying; Pineda, Mario; Gan, Rong Z

    2016-09-01

    Otitis media (OM) is an inflammatory or infectious disease of the middle ear. Acute otitis media (AOM) and otitis media with effusion (OME) are the two major types of OM. However, the tympanic membrane (TM) motion differences induced by AOM and OME have not been quantified in animal models in the literature. In this study, the guinea pig AOM and OME models were created by transbullar injection of Streptococcus pneumoniae type 3 and lipopolysaccharide, respectively. To explore the effects of OM on the entire TM vibration, the measurements of full-field TM motions were performed in the AOM, OME and untreated control ears by using scanning laser Doppler vibrometry (SLDV). The results showed that both AOM and OME generally reduced the displacement peak and produced the traveling-wave-like motions at relatively low frequencies. Compared with the normal ear, OME resulted in a significant change of the TM displacement mainly in the inferior portion of the TM, and AOM significantly affected the surface motion across four quadrants. The SLDV measurements provide more insight into sound-induced TM vibration in diseased ears. PMID:27490002

  19. Novel laser Doppler flowmeter for pulpal blood flow measurements

    NASA Astrophysics Data System (ADS)

    Zang, De Yu; Millerd, James E.; Wilder-Smith, Petra B. B.; Arrastia-Jitosho, Anna-Marie A.

    1996-04-01

    We have proposed and experimentally demonstrated a new configuration of laser Doppler flowmetry for dental pulpal blood flow measurements. To date, the vitality of a tooth can be determined only by subjective thermal or electric tests, which are of questionable reliability and may induced pain in patient. Non-invasive techniques for determining pulpal vascular reactions to injury, treatment, and medication are in great demand. The laser Doppler flowmetry technique is non-invasive; however, clinical studies have shown that when used to measure pulpal blood flow the conventional back-scattering Doppler method suffers from low signal-to-noise ratio (SNR) and unreliable flux readings rendering it impossible to calibrate. A simplified theoretical model indicates that by using a forward scattered geometry the detected signal has a much higher SNR and can be calibrated. The forward scattered signal is readily detectable due to the fact that teeth are relatively thin organs with moderate optical loss. A preliminary experiment comparing forward scattered detection with conventional back- scattered detection was carried out using an extracted human molar. The results validated the findings of the simple theoretical model and clearly showed the utility of the forward scattering geometry. The back-scattering method had readings that fluctuated by as much as 187% in response to small changes in sensor position relative to the tooth. The forward scattered method had consistent readings (within 10%) that were independent of the sensor position, a signal-to-noise ratio that was at least 5.6 times higher than the back-scattering method, and a linear response to flow rate.

  20. Measuring with laser Doppler vibrometer on moving frame (LDVMF)

    NASA Astrophysics Data System (ADS)

    Rahimi, Siamand; Li, Zili; Dollevoet, Rolf

    2014-05-01

    Structural dynamic gives insight into structural properties such as mass, eigenfrequencies, eigenmodes, modal damping and strain distribution and can be utilized in structural health monitoring, dynamic sub-structuring, etc. In this context structural vibration is measured and used. The measurement is done by means of conventional sensors such as accelerometers or non destructively using Laser Doppler Vibrometer (LDV), for instance. The non-destructive, non-contact measurement techniques preserve the integrity of the structure and don't add mass and stiffness to the structure under test. When one deals with civil structures such as rail and road ways, pipelines and catenary the importance of these techniques becomes more evident as they allow standoff measurement on a moving frame. Nevertheless when LDV is employed due to the relative in-plane motion between the LDV and the target speckle noise is generated which degrades the signal quality and makes this application not very straightforward but challenging. One of the first Laser Doppler Vibrometer on moving frame is adopted to measure and monitor the ground vibration, aiming at detection of buried land mines. The major addressed difficulty in this application is the speckle noise present in the acquired signal. In general the signal quality and the Signal to Noise Ratio (SNR) are a function of the laser spot size and wave length, measurement distance, relative velocity and sampling frequency. A trade-off between these factors, which are not always intuitive would help to minimize the noise floor due to the speckle noise. In this paper a test rig is presented which allows to study the speckle noise at different measurement ranges, between 1.8 and 2.8 m, and different velocities, up to 150 km/h. The results might serve as a guideline to the design process of a LDVMF.

  1. Remote measurement utilizing NASA's scanning laser Doppler systems. Volume 1. Laser Doppler wake vortex tracking at Kennedy Airport

    NASA Technical Reports Server (NTRS)

    Krause, M. C.; Wilson, D. J.; Howle, R. E.; Edwards, B. B.; Craven, C. E.; Jetton, J. L.

    1976-01-01

    Test operations of the Scanning Laser Doppler System (SLDS) at Kennedy International Airport (KIA) during August 1974 through June 1975 are reported. A total of 1,619 data runs was recorded with a totally operational system during normal landing operations at KIA. In addition, 53 data runs were made during cooperative flybys with the C880 for a grand total of 1672 recorded vortex tracks. Test crews were in attendance at KIA for 31 weeks, of which 25 weeks were considered operational and the other six were packing, unpacking, setup and check out. Although average activity equates to 67 recorded landing operations per week, two periods of complete runway inactivity spanned 20 days and 13 days, respectively. The operation frequency therefore averaged about 88 operations per week.

  2. Data processing and display of laser Doppler experimental results, volume 1

    NASA Technical Reports Server (NTRS)

    Ashmore, B. R.; Kimura, A.; Skeith, R. W.

    1976-01-01

    Contract activities performed in developing a laser Doppler system for detecting, tracking, and measuring aircraft wake vortices are summarized. The computer program for processing and displaying the Dust Devil experimental data is presented. Program listings are included in the appendix.

  3. A comparison of a coaxial focused laser Doppler system in atmospheric measurements

    NASA Technical Reports Server (NTRS)

    Karaki, S.

    1973-01-01

    Measurements of atmospheric velocities and turbulence with the laser Doppler system were obtained, and the results compared with cup anemometer and hot-wire measurements in the same wind field. The laser Doppler velocimeter (LDV) is described along with the test procedures. It was found that mean values determined from the LDV data are within 5% of other anemometer data for long time periods, and the LDV measures higher velocities.

  4. Laser Doppler phase shifting using a high-speed digital micromirror device

    NASA Astrophysics Data System (ADS)

    Kuo, D.; Sharpe, J. P.

    2015-03-01

    Here we demonstrate the use of a binary spatial light modulator (Texas Instruments Digital Micromirror Device) to impart a phase shift to the beams of a laser Doppler velocimeter. Advantages of this approach to laser Doppler phase shifting include low cost, low power consumption, a precisely known phase-stepping frequency and the capability of working with a broad range of optical wavelengths. In the implementation shown here velocities of order 1 cm/s are measured.

  5. Relevance of laser Doppler and laser speckle techniques for assessing vascular function: state of the art and future trends.

    PubMed

    Humeau-Heurtier, A; Guerreschi, E; Abraham, P; Mahé, G

    2013-03-01

    In clinical and research applications, the assessment of vascular function has become of major importance to evaluate and follow the evolution of cardiovascular pathologies, diabetes, hypertension, or foot ulcers. Therefore, the development of engineering methodologies able to monitor noninvasively blood vessel activities-such as endothelial function-is a significant and emerging challenge. Laser-based techniques have been used to respond-as much as possible-to these requirements. Among them, laser Doppler flowmetry (LDF) and laser Doppler imaging (LDI) were proposed a few decades ago. They provide interesting vascular information but possess drawbacks that prevent an easy use in some clinical situations. Recently, the laser speckle contrast imaging (LSCI) technique, a noninvasive camera-based tool, was commercialized and overcomes some of the LDF and LDI weaknesses. Our paper describes how-using engineering methodologies-LDF, LDI, and LSCI can meet the challenging clinician needs in assessing vascular function, with a special focus on the state of the art and future trends.

  6. Particle sizing experiments with the laser Doppler velocimeter: Final report

    SciTech Connect

    Giel, T.V. Jr.; Son, J.Y.

    1988-06-01

    Measurement techniques for in-situ simultaneous measurements of particle size distributions and particle velocities using the dual beam laser Doppler velocimeter (LV) were analytically and experimentally investigated. This investigation examined the different signal characteristics of the LV for determination of particle size and particle velocity, simultaneously. The different size related signal components were evaluated not only singularly but also as simultaneous measurements to determine which characteristic, or combination of characteristics, provided the best measure of particle size. The evaluation concentrated on the 0.5 to 5 ..mu..m particle size range, in which the LV light scattering characteristics are complex often non-monotonic functions of the particle size as well as functions of index of refraction, the laser light wavelength, laser intensity and polarization, and the location and response characteristics of the detector. Different components of the LV signal were considered, but analysis concentrated on Doppler phase, visibility and scatter-intensity because they show the greatest promise. These signals characteristics were initially defined analytically for numerous optical configurations over the 0.5 to 5 ..mu..m diameter range with 0.1 ..mu..m segmentation, for refractive index values from 1.0 to 3.0 with absorptive (imaginary) components varied form 0 to 1.0. Collector orientation and effective f/No., as well as fringe spacing, beam polarization and wavelength, were varied in this analytical evaluation. 18 refs., 42 figs., 5 tabs.

  7. Standoff photoacoustic sensing of trace chemicals by laser Doppler vibrometer

    NASA Astrophysics Data System (ADS)

    Fu, Y.; Hu, Q.; Liu, H.

    2016-05-01

    Photoacoustic spectroscopy (PAS) is a useful technique that suitable for trace detection of chemicals and explosives. Normally a high-sensitive microphone or a quartz tuning fork is used to detect the signal in photoacoustic cell. In recent years, laser Doppler vibrometer (LDV) is proposed to remote-sense photoacoustic signal on various substrates. It is a high-sensitivity sensor with a displacement resolution of <10pm. In this research, the photoacoustic effect of various chemicals is excited by a quantum cascade laser (QCL) with a scanning wavelength range of 6.89μm to 8.5 μm. A home-developed LDV at 1550nm wavelength is applied to detect the vibration signal. After normalize the vibration amplitude with QCL power, the photoacoustic spectrum of various chemicals can be obtained. Different factors that affect the detection accuracy and sensitivity have also been discussed. The results show the potential of the proposed technique for standoff detection of trace chemicals and explosives.

  8. Vocal fold vibration measurements using laser Doppler vibrometry

    PubMed Central

    Chan, Alfred; Mongeau, Luc; Kost, Karen

    2013-01-01

    The objective of this study was to measure the velocity of the superior surface of human vocal folds during phonation using laser Doppler vibrometry (LDV). A custom-made endoscopic laser beam deflection unit was designed and fabricated. An in vivo clinical experimental procedure was developed to simultaneously collect LDV velocity and video from videolaryngoscopy. The velocity along the direction of the laser beam, i.e., the inferior-superior direction, was captured. The velocity was synchronous with electroglottograph and sound level meter data. The vibration energy of the vocal folds was determined to be significant up to a frequency of 3 kHz. Three characteristic vibrational waveforms were identified which may indicate bifurcations between vibrational modes of the mucosal wave. No relationship was found between the velocity amplitude and phonation frequency or sound pressure level. A correlation was found between the peak-to-peak displacement amplitude and phonation frequency. A sparse map of the velocity amplitudes on the vocal fold surface was obtained. PMID:23464036

  9. Application of the laser Doppler velocimeter in aerodynamic flows

    NASA Technical Reports Server (NTRS)

    Yanta, W. J.; Ausherman, D. W.

    1982-01-01

    Applications of the laser doppler velocimeter (LDV) are discussed. Measurements were made of the flowfield around a tangent-ogive model in a low turbulent, incompressible flow at an incidence of 45 deg. The free-stream velocity was 80 ft per second. The flowfield velocities in several cross-flow planes were measured with a 2-D, two-color LDC operated in a backscatter mode. Measurements were concentrated in the secondary separation region. A typical survey is given. The survey was taken at a model location where the maximum side force occurs. The overall character of the leeward flowfield with the influence of the two body vorticles are shown. Measurements of the velocity and density flowfields in the shock-layer region of a reentry-vehicle indented nose configuration were carried out at Mach 5. The velocity flowfield was measured with a 2-color, 2-D, forward-scatter LDV system. Because of the need to minimize particle lag in the shock-layer region, polystyrene particles with a mean diameter of 0.312 microns were used for the scattering particles. The model diameter was 6 inches.

  10. Arterial compliance measurement using a noninvasive laser Doppler measurement system

    NASA Astrophysics Data System (ADS)

    Hast, Jukka T.; Myllylae, Risto A.; Sorvoja, Hannu; Nissilae, Seppo M.

    2000-11-01

    The aim of this study was to study the elasticity of the arterial wall using a non-invasive laser Doppler measurement system. The elasticity of the arterial wall is described by its compliance factor, which can be determined when both blood pressure and the radial velocity of the arterial wall are known. To measure radical velocity we used a self- mixing interferometer. The compliance factors were measured from six healthy volunteers, whose ages were varied from 21 to 32. Although a single volunteer's compliance factor is presented as an example, this paper treated the volunteers as a group. First, the elastic modulus, which is inversely proportional to the compliance factor, was determined. Then, an exponential curve was fitted into the measured data and a characteristic equation for the elastic modulus of the arterial wall was determined. The elastic modulus was calculated at different pressures and the results were compared to the static incremental modulus of a dog's femoral artery. The results indicate that there is a correlation between human elastic and canine static incremental modulus for blood pressures varying from 60 to 110 mmHg.

  11. Model-based quantitative laser Doppler flowmetry in skin

    NASA Astrophysics Data System (ADS)

    Fredriksson, Ingemar; Larsson, Marcus; Strömberg, Tomas

    2010-09-01

    Laser Doppler flowmetry (LDF) can be used for assessing the microcirculatory perfusion. However, conventional LDF (cLDF) gives only a relative perfusion estimate for an unknown measurement volume, with no information about the blood flow speed distribution. To overcome these limitations, a model-based analysis method for quantitative LDF (qLDF) is proposed. The method uses inverse Monte Carlo technique with an adaptive three-layer skin model. By analyzing the optimal model where measured and simulated LDF spectra detected at two different source-detector separations match, the absolute microcirculatory perfusion for a specified speed region in a predefined volume is determined. qLDF displayed errors <12% when evaluated using simulations of physiologically relevant variations in the layer structure, in the optical properties of static tissue, and in blood absorption. Inhomogeneous models containing small blood vessels, hair, and sweat glands displayed errors <5%. Evaluation models containing single larger blood vessels displayed significant errors but could be dismissed by residual analysis. In vivo measurements using local heat provocation displayed a higher perfusion increase with qLDF than cLDF, due to nonlinear effects in the latter. The qLDF showed that the perfusion increase occurred due to an increased amount of red blood cells with a speed >1 mm/s.

  12. Vocal fold vibration measurements using laser Doppler vibrometry.

    PubMed

    Chan, Alfred; Mongeau, Luc; Kost, Karen

    2013-03-01

    The objective of this study was to measure the velocity of the superior surface of human vocal folds during phonation using laser Doppler vibrometry (LDV). A custom-made endoscopic laser beam deflection unit was designed and fabricated. An in vivo clinical experimental procedure was developed to simultaneously collect LDV velocity and video from videolaryngoscopy. The velocity along the direction of the laser beam, i.e., the inferior-superior direction, was captured. The velocity was synchronous with electroglottograph and sound level meter data. The vibration energy of the vocal folds was determined to be significant up to a frequency of 3 kHz. Three characteristic vibrational waveforms were identified which may indicate bifurcations between vibrational modes of the mucosal wave. No relationship was found between the velocity amplitude and phonation frequency or sound pressure level. A correlation was found between the peak-to-peak displacement amplitude and phonation frequency. A sparse map of the velocity amplitudes on the vocal fold surface was obtained.

  13. A scanning laser Doppler vibrometer for modal testing

    SciTech Connect

    Sriram, P.; Craig, J.I.; Hanagud, S. )

    1990-07-01

    Accelerometers are widely used to sense structural response in modal testing. The mass loading and local effects due to accelerometers are not always negligible. The laser Doppler velocimeter/vibrometer (LDV) is a noncontact optical sensing tool for accurately measuring point velocities. The noncontact nature of the instrument makes it particularly attractive for use on lightweight structures where measurement interaction must be minimized. Real-time scanning LDV's have recently been introduced to measure fluid flow velocity profiles rapidly. In this paper, the development of a real-time scanning LDV for structural applications is described. The instrument can be used to simultaneously measure the velocity response at a series of locations on a vibrating structure. Standard modal analysis techniques can then be applied to extract the usual modal data, e.g., natural frequencies, damping and mode shapes. The special case of beam vibration is considered in this paper though the technique can be readily extended to generic planar measurements. The measurement technique has been validated through modal testing of a simple beam structure. Comparisons between theoretical and LDV measured mode shapes and natural frequencies are presented. 20 refs.

  14. Detrended fluctuation analysis of laser Doppler flowmetry time series.

    PubMed

    Esen, Ferhan; Aydin, Gülsün Sönmez; Esen, Hamza

    2009-12-01

    Detrended fluctuation analysis (DFA) of laser Doppler flow (LDF) time series appears to yield improved prognostic power in microvascular dysfunction, through calculation of the scaling exponent, alpha. In the present study the long lasting strenuous activity-induced change in microvascular function was evaluated by DFA in basketball players compared with sedentary control. Forearm skin blood flow was measured at rest and during local heating. Three scaling exponents, the slopes of the three regression lines, were identified corresponding to cardiac, cardio-respiratory and local factors. Local scaling exponent was always approximately one, alpha=1.01+/-0.15, in the control group and did not change with local heating. However, we found a broken line with two scaling exponents (alpha(1)=1.06+/-0.01 and alpha(2)=0.75+/-0.01) in basketball players. The broken line became a single line having one scaling exponent (alpha(T)=0.94+/-0.01) with local heating. The scaling exponents, alpha(2) and alpha(T), smaller than 1 indicate reduced long-range correlation in blood flow due to a loss of integration in local mechanisms and suggest endothelial dysfunction as the most likely candidate. Evaluation of microvascular function from a baseline LDF signal at rest is the superiority of DFA to other methods, spectral or not, that use the amplitude changes of evoked relative signal. PMID:19660479

  15. Novel measure for the calibration of laser Doppler flowmetry devices

    NASA Astrophysics Data System (ADS)

    Dunaev, Andrey V.; Zherebtsov, Evgeny A.; Rogatkin, Dmitrii A.; Stewart, Neil A.; Sokolovski, Sergei G.; Rafailov, Edik U.

    2014-03-01

    The metrological basis for optical non-invasive diagnostic devices is an unresolved issue. A major challenge for laser Doppler flowmetry (LDF) is the need to compare the outputs from individual devices and various manufacturers to identify variations useful in clinical diagnostics. The most common methods for instrument calibration are simulants or phantoms composed of colloids of light-scattering particles which simulate the motion of red blood cells based on Brownian motion. However, such systems have limited accuracy or stability and cannot calibrate for the known rhythmic components of perfusion (0.0095-1.6 Hz). To solve this problem, we propose the design of a novel technique based on the simulation of moving particles using an electromechanical transducer, in which a precision piezoelectric actuator is used (e.g., P-602.8SL with maximum movement less than 1 mm). In this system, Doppler shift is generated in the layered structure of different solid materials with different optical light diffusing properties. This comprises a fixed, light transparent upper plane-parallel plate and an oscillating fluoroplastic (PTFE) disk. Preliminary studies on this experimental setup using the LDF-channel of a "LAKK-M" system demonstrated the detection of the linear portion (0-10 Hz with a maximum signal corresponding to Doppler shift of about 20 kHz) of the LDF-signal from the oscillating frequency of the moving layer. The results suggest the possibility of applying this technique for the calibration of LDF devices.

  16. Vocal fold vibration measurements using laser Doppler vibrometry.

    PubMed

    Chan, Alfred; Mongeau, Luc; Kost, Karen

    2013-03-01

    The objective of this study was to measure the velocity of the superior surface of human vocal folds during phonation using laser Doppler vibrometry (LDV). A custom-made endoscopic laser beam deflection unit was designed and fabricated. An in vivo clinical experimental procedure was developed to simultaneously collect LDV velocity and video from videolaryngoscopy. The velocity along the direction of the laser beam, i.e., the inferior-superior direction, was captured. The velocity was synchronous with electroglottograph and sound level meter data. The vibration energy of the vocal folds was determined to be significant up to a frequency of 3 kHz. Three characteristic vibrational waveforms were identified which may indicate bifurcations between vibrational modes of the mucosal wave. No relationship was found between the velocity amplitude and phonation frequency or sound pressure level. A correlation was found between the peak-to-peak displacement amplitude and phonation frequency. A sparse map of the velocity amplitudes on the vocal fold surface was obtained. PMID:23464036

  17. Detrended fluctuation analysis of laser Doppler flowmetry time series.

    PubMed

    Esen, Ferhan; Aydin, Gülsün Sönmez; Esen, Hamza

    2009-12-01

    Detrended fluctuation analysis (DFA) of laser Doppler flow (LDF) time series appears to yield improved prognostic power in microvascular dysfunction, through calculation of the scaling exponent, alpha. In the present study the long lasting strenuous activity-induced change in microvascular function was evaluated by DFA in basketball players compared with sedentary control. Forearm skin blood flow was measured at rest and during local heating. Three scaling exponents, the slopes of the three regression lines, were identified corresponding to cardiac, cardio-respiratory and local factors. Local scaling exponent was always approximately one, alpha=1.01+/-0.15, in the control group and did not change with local heating. However, we found a broken line with two scaling exponents (alpha(1)=1.06+/-0.01 and alpha(2)=0.75+/-0.01) in basketball players. The broken line became a single line having one scaling exponent (alpha(T)=0.94+/-0.01) with local heating. The scaling exponents, alpha(2) and alpha(T), smaller than 1 indicate reduced long-range correlation in blood flow due to a loss of integration in local mechanisms and suggest endothelial dysfunction as the most likely candidate. Evaluation of microvascular function from a baseline LDF signal at rest is the superiority of DFA to other methods, spectral or not, that use the amplitude changes of evoked relative signal.

  18. Self-mixing dual-frequency laser Doppler velocimeter.

    PubMed

    Cheng, Chih-Hao; Lin, Lyu-Chih; Lin, Fan-Yi

    2014-02-10

    A self-mixing (SM) dual-frequency (DF) laser Doppler velocimeter (LDV) (SM DF-LDV) is proposed and studied, which integrates the advantages of both the SM-LDV and the DF-LDV. An optically injected semiconductor laser operated in a dual-frequency period-one (P1) dynamical state is used as the light source. By probing the target with the light-carried microwave generated from the beat of the two optical frequency components, the spectral broadening in the Doppler signal due to the speckle noise can be significantly reduced. Together with an SM configuration, the SM DF-LDV has the advantages of direction discriminability, self-alignment, high sensitivity, and compact setup. In this study, speckle noise reduction and direction discriminability with an SM DF-LDV are demonstrated. The signal-to-noise ratios (SNRs) at different feedback powers are investigated. Benefiting from the high sensitivity of the SM configuration, an SNR of 23 dB is achieved without employing an avalanched photodetector or photomultiplier tube. The velocity resolution and the SNR under different speckle noise conditions are studied. Average velocity resolution of 0.42 mm/s and SNR of 22.1 dB are achieved when a piece of paper is rotating at a transverse velocity of 5 m/s. Compared with a conventional single-frequency LDV (SF-LDV), the SM DF-LDV shows improvements of 20-fold in the velocity resolution and 8 dB in the SNR.

  19. Full-field strain measurements on turbomachinery components using 3D SLDV technology

    NASA Astrophysics Data System (ADS)

    Maguire, Martyn; Sever, Ibrahim

    2016-06-01

    This paper focuses on measurements of 3D Operating Deflection Shapes (ODSs), and subsequently, construction of full-field surface strain maps of a number of turbomachinery components. For this purpose a 3D Scanning Laser Doppler Vibrometer (SLDV) is used. The ODS measurements are performed for a large number of modes and results obtained are compared with the 1-D shapes that are most commonly measured. It is demonstrated that the 3D measurements are a significant improvement over the 1-D case in terms of independent amount of extra information they provide. This is confirmed through comparisons with FE results. Special tests are carried out to recover the full-field strain on scanned faces of the components used. Visual comparison of these measurements with FE counterparts reveal that strain maps can be successfully measured, not only for low frequency modes but also for highly complex high frequency ones. These maps are measured with different levels of input force to assess the linearity of strain results to varying response amplitudes. Lessons learnt and observations made are summarised in concluding remarks and the scope of future work to take this study into the production environment is discussed. This study constitutes a unique comprehensive investigation into full-field strain measurements using real application hardware and a large frequency range.

  20. Characterization and demonstration of a 12-channel Laser-Doppler vibrometer

    NASA Astrophysics Data System (ADS)

    Haist, T.; Lingel, C.; Osten, W.; Bendel, K.; Giesen, M.; Gartner, M.; Rembe, C.

    2013-04-01

    Scanning laser-Doppler vibrometry is the standard optical, non-contact technology for vibration measurement applications in all areas of mechanical engineering. The vibration signals are measured from the different measurement points at different time points. This requires synchronization and the technology is limited to repeatable or periodic events. We have explored a new solution for the optical setup of the sensing system of a multi-channel vibrometer that we present in this paper. Our optical system is a 12-channel vibrometer and consists of a 12-channel interferometer unit which is connected with 12 optical fibers to a sensor head with 12 fiber-coupled objective lenses. Every objective lens can be focused manually and is placed in a sphere which can be tilted and fixed by a blocking screw. Thus it is possible to adjust a user defined measurement grid by hand. The user can define the geometry of the measurement grid in a camera image displayed in the software by just clicking on the laser foci. We use synchronous analog-digital conversion for the 12 heterodyne detector signals and a digital 12-channel-demodulator which is connected via USB to a computer. We can realize high deflection angles, good sensitivity, proper resolution, sufficient vibration bandwidth, and high maximum vibration amplitudes. In this paper, we demonstrate the optical and electrical setup of the manually adjustable 12-channel vibrometer, we present the experimentally evaluated performance of our device, and we present first measurements from real automotive applications.

  1. Nonperturbing measurements of spatially distributed underwater acoustic fields using a scanning laser Doppler vibrometer.

    PubMed

    Harland, Andy R; Petzing, Jon N; Tyrer, John R

    2004-01-01

    Localized changes in the density of water induced by the presence of an acoustic field cause perturbations in the localized refractive index. This relationship has given rise to a number of nonperturbing optical metrology techniques for recording measurement parameters from underwater acoustic fields. A method that has been recently developed involves the use of a Laser Doppler Vibrometer (LDV) targeted at a fixed, nonvibrating, plate through an underwater acoustic field. Measurements of the rate of change of optical pathlength along a line section enable the identification of the temporal and frequency characteristics of the acoustic wave front. This approach has been extended through the use of a scanning LDV, which facilitates the measurement of a range of spatially distributed parameters. A mathematical model is presented that relates the distribution of pressure amplitude and phase in a planar wave front with the rate of change of optical pathlength measured by the LDV along a specifically orientated laser line section. Measurements of a 1 MHz acoustic tone burst generated by a focused transducer are described and the results presented. Graphical depictions of the acoustic power and phase distribution recorded by the LDV are shown, together with images representing time history during the acoustic wave propagation.

  2. Photothermal excitation and laser Doppler velocimetry of higher cantilever vibration modes for dynamic atomic force microscopy in liquid

    SciTech Connect

    Nishida, Shuhei; Kobayashi, Dai; Sakurada, Takeo; Nakazawa, Tomonori; Hoshi, Yasuo; Kawakatsu, Hideki

    2008-12-15

    The authors present an optically based method combining photothermal excitation and laser Doppler velocimetry of higher cantilever vibration modes for dynamic atomic force microscopy in liquid. The frequency spectrum of a silicon cantilever measured in water over frequencies ranging up to 10 MHz shows that the method allows us to excite and detect higher modes, from fundamental to fifth flexural, without enhancing spurious resonances. By reducing the tip oscillation amplitude using higher modes, the average tip-sample force gradient due to chemical bonds is effectively increased to achieve high-spatial-resolution imaging in liquid. The method's performance is demonstrated by atomic resolution imaging of a mica surface in water obtained using the second flexural mode with a small tip amplitude of 99 pm; individual atoms on the surface with small height differences of up to 60 pm are clearly resolved.

  3. Time division multiplexed laser Doppler anemometry using pulsed laser diodes and optical fibers

    SciTech Connect

    Lockey, R.A.; Tatam, R.P.

    1995-12-31

    Laser Doppler anemometry (LDA) is a well established technique for non-invasive measurement of fluid flow, by measuring the frequency shift of light scattered by particles entrained in the flow. A time division multiplexed laser Doppler anemometer is reported, using a single high frequency pulsed laser diode as a source. Time division multiplexing requires a single detector channel, removing the need for multiple detectors and wavelength separation optics found in conventional CW laser Doppler systems. By incorporating optical fibers into the system to distribute the pulses into each channel and impose a delay between channels, the electronic requirements of such an instrument are reduced. Results for a two-dimensional system are presented, measured on a water-seeded air jet. Individual velocity components of up to 16 ms{sup {minus}1} and overall velocities of up to 20 ms{sup {minus}1} have been detected, but the potential range of the instrument is very much greater.

  4. Note: Laser Doppler velocimeter using a dual-longitudinal-mode laser source.

    PubMed

    Xiaoming, Nie; Jian, Zhou; Xingwu, Long

    2012-10-01

    This paper presents a new laser Doppler technique using a dual-longitudinal-mode He-Ne laser as the laser source. Theoretical analysis shows that the Doppler frequency is proportional with the frequency difference of the two modes. The Doppler frequency in this technique is very low compared with the one in the single-mode laser Doppler technique. The new laser Doppler technique can be used to measure high speed. Experiment results show that the Doppler frequency is only about 82 Hz while the measurement speed reaches 31.4 m∕s. The signal-to-noise ratio of the Doppler signal is improved by the technique of digital filter and digital autocorrelation.

  5. Middle ear transmission disorders--tympanic membrane vibration analysis by laser-Doppler-vibrometry.

    PubMed

    Stasche, N; Foth, H J; Hörmann, K; Baker, A; Huthoff, C

    1994-01-01

    Laser-Doppler-vibrometry is a useful method to measure vibrations of the tympanic membrane. It is suitable to objectively diagnose the middle ear. In comparison to tympanometry, laser-Doppler-vibrometry has greater sensitivity. Temporal bone specimens were specially prepared to simulate middle ear disorders like middle ear effusion, fixation of the malleus head, fixation of the stapes footplate and removal of the incus. A correlation between the displacement function of the umbo and the experimentally produced middle ear disorders could be demonstrated. For the first time it was possible to measure the vibration of the tympanic membrane by using a laser-Doppler-vibrometer in a healthy 25-year-old male.

  6. In operando study of the high voltage spinel cathode material LiNi(0.5)Mn(1.5)O4 using two dimensional full-field spectroscopic imaging of Ni and Mn.

    PubMed

    Bauer, Sondes; de Biasi, Lea; Glatthaar, Sven; Toukam, Leonel; Gesswein, Holger; Baumbach, Tilo

    2015-07-01

    LiNi0.5Mn1.5O4 spinel cathode was studied during the first discharge cycle using combined full field Transmission X-ray Microscopy (TXM) and X-ray Absorption Near Edge Structure Spectroscopy (XANES) techniques to follow the chemical phase transformation as well as the microstructural evolution of cathode materials upon operation within an electrochemical cell. The spatial distribution and electrochemical process of the spinel material with spherical granules of 30 μm and 3 μm crystallite size was investigated. The spectroscopic imaging of the cathode within field of view of 40 × 32 μm(2) and spatial resolution of 40 nm has revealed an increase of the LiNi0.5Mn1.5O4 granule size during lithiation providing an insight into the effect of the particle size and morphology on the electrochemical process. The chemical elemental distribution and the content of the different oxidation states of the two absorbing elements (Ni and Mn) have been determined in operando from the XANES imaging. A gradual increase in the content of the oxidation state Mn(3+) from 8% up to 64% has been recorded during the discharge from 5 V to 2.7 V. The study of the local oxidation reduction behavior of Mn(3+) reveals a reversibility aspect in the local electrochemical reaction of Mn(4+) toward Mn(3+) in areas located in the center of the aggregate as well as in areas closed to the electrolyte. During the discharge process, a mixture of Mn(3+) and Mn(4+) has been detected while only single electron valence states have been found in the case of Ni. Probing the chemical changes during the discharge using two-dimensional XANES reveals spatial differences in the electrochemical activities of the two absorbing elements Ni and Mn. PMID:26051380

  7. In operando study of the high voltage spinel cathode material LiNi(0.5)Mn(1.5)O4 using two dimensional full-field spectroscopic imaging of Ni and Mn.

    PubMed

    Bauer, Sondes; de Biasi, Lea; Glatthaar, Sven; Toukam, Leonel; Gesswein, Holger; Baumbach, Tilo

    2015-07-01

    LiNi0.5Mn1.5O4 spinel cathode was studied during the first discharge cycle using combined full field Transmission X-ray Microscopy (TXM) and X-ray Absorption Near Edge Structure Spectroscopy (XANES) techniques to follow the chemical phase transformation as well as the microstructural evolution of cathode materials upon operation within an electrochemical cell. The spatial distribution and electrochemical process of the spinel material with spherical granules of 30 μm and 3 μm crystallite size was investigated. The spectroscopic imaging of the cathode within field of view of 40 × 32 μm(2) and spatial resolution of 40 nm has revealed an increase of the LiNi0.5Mn1.5O4 granule size during lithiation providing an insight into the effect of the particle size and morphology on the electrochemical process. The chemical elemental distribution and the content of the different oxidation states of the two absorbing elements (Ni and Mn) have been determined in operando from the XANES imaging. A gradual increase in the content of the oxidation state Mn(3+) from 8% up to 64% has been recorded during the discharge from 5 V to 2.7 V. The study of the local oxidation reduction behavior of Mn(3+) reveals a reversibility aspect in the local electrochemical reaction of Mn(4+) toward Mn(3+) in areas located in the center of the aggregate as well as in areas closed to the electrolyte. During the discharge process, a mixture of Mn(3+) and Mn(4+) has been detected while only single electron valence states have been found in the case of Ni. Probing the chemical changes during the discharge using two-dimensional XANES reveals spatial differences in the electrochemical activities of the two absorbing elements Ni and Mn.

  8. MAMA Full Field Sensitivity Monitor & PSF Check

    NASA Astrophysics Data System (ADS)

    Proffitt, Charles

    2009-07-01

    The purpose of this program is to monitor the sensitivity of the MAMAdetectors over the full field. This is achieved by observing globularcluster NGC6681 once during Cycle 17. The data can be directlycompared with similar data obtained in Cycles 7, 8, 9, 10, 11, and 12.

  9. Differential Laser Doppler based Non-Contact Sensor for Dimensional Inspection with Error Propagation Evaluation

    PubMed Central

    Mekid, Samir; Vacharanukul, Ketsaya

    2006-01-01

    To achieve dynamic error compensation in CNC machine tools, a non-contact laser probe capable of dimensional measurement of a workpiece while it is being machined has been developed and presented in this paper. The measurements are automatically fed back to the machine controller for intelligent error compensations. Based on a well resolved laser Doppler technique and real time data acquisition, the probe delivers a very promising dimensional accuracy at few microns over a range of 100 mm. The developed optical measuring apparatus employs a differential laser Doppler arrangement allowing acquisition of information from the workpiece surface. In addition, the measurements are traceable to standards of frequency allowing higher precision.

  10. Modelling and experimental analysis of the performance of a laser Doppler vibrometer used to measure vibrations through combustive flows

    NASA Astrophysics Data System (ADS)

    Paone, Nicola; Revel, Gian Marco

    1998-08-01

    The problem of measuring surface vibrations by a laser Doppler vibrometer operating with the measuring beam across a combustive flow is discussed, in order to assess the possibility of experimentally determining the dynamic behaviour of a burner under operating conditions. The instrument performance is analysed in terms of interfering and modifying inputs through the development of a model of the interferometer and by experimental validation of its predictions. Experiments are carried out on an unconfined CH 4 flame of a Bunsen burner and a metal surface under a known forced vibration. The laser vibrometer output is influenced by the presence of the flame: major effects are optical path length variations of the measuring arm of the interferometer and beam movements. All effects occur at the typical flame flickering frequency and cause a distorted vibration spectra and a reduced signal-to-noise ratio. Beam wandering and defocusing are documented by image acquisition.

  11. Engineering photonics: from nanoscale sensing to full-field interferometry

    NASA Astrophysics Data System (ADS)

    Tatam, Ralph P.

    2005-09-01

    This paper will present recent developments in optical fibre sensors and optical fibre based instrumentation research undertaken at Cranfield University. New sensor techniques based on nanoscale molecular coatings deposited on singlemode fibres containing long period gratings and the use of singlemode fibres and coherent imaging fibre bundles in full-field speckle interferometry and planar Doppler velocimetry will be presented.

  12. Laser Resurfacing: Full Field and Fractional.

    PubMed

    Pozner, Jason N; DiBernardo, Barry E

    2016-07-01

    Laser resurfacing is a very popular procedure worldwide. Full field and fractional lasers are used in many aesthetic practices. There have been significant advances in laser resurfacing in the past few years, which make patient treatments more efficacious and with less downtime. Erbium and carbon dioxide and ablative, nonablative, and hybrid fractional lasers are all extremely effective and popular tools that have a place in plastic surgery and dermatology offices. PMID:27363765

  13. Does topical minoxidil increase skin blood flow? A laser Doppler flowmetry study.

    PubMed

    de Boer, E M; Bezemer, P D; Bruynzeel, D P; Nieboer, C

    1988-01-01

    Cutaneous blood flow was measured by Laser Doppler Flowmetry after topical application of minoxidil lotion, in 9 healthy males with androgenetic alopecia, and other volunteers. No reaction in the cutaneous blood flow was seen after application of 2%, 5%, or placebo minoxidil lotion.

  14. Development of CO2 laser Doppler instrumentation for detection of clear air turbulence, volume 1

    NASA Technical Reports Server (NTRS)

    Harris, C. E.; Jelalian, A. V.

    1979-01-01

    Modification, construction, test and operation of an advanced airborne carbon dioxide laser Doppler system for detecting clear air turbulence are described. The second generation CAT program and those auxiliary activities required to support and verify such a first-of-a-kind system are detailed: aircraft interface; ground and flight verification tests; data analysis; and laboratory examinations.

  15. The flaws of laser Doppler in negative-pressure wound therapy research.

    PubMed

    Kairinos, Nicolas; McKune, Andrew; Solomons, Michael; Hudson, Donald A; Kahn, Delawir

    2014-01-01

    Recent studies, using modalities other than laser Doppler, have indicated that perfusion during negative-pressure wound therapy (NPWT) is reduced, contrary to world literature. The aim of the present study was to evaluate whether the measuring technique of the laser Doppler could be influenced by the compressive nature of NPWT dressings and whether this could explain the conflicting findings. A hypothesis that it may be possible for laser Doppler to record similar readings to those obtained during NPWT by merely compressing tissues manually was tested on 12 NPWT dressings, with each undergoing an alternating series of manual compressive forces and NPWT (-125 mmHg). During the periods of NPWT (n = 12), the mean perfusion recording increased in five experiments, reduced in six, and remained unchanged in one. During the period when manual pressure was applied (n = 12), there was a mean increase in perfusion in six experiments and a reduction in six. The type of change in perfusion (increase or decrease) was the same for both NPWT and manual pressure in 10 of the 12 experiments. In conclusion, laser Doppler can incorrectly record increased perfusion when tissues are compressed, implying that it is flawed in the field of NPWT research as tissues are always compressed to some degree by the NPWT dressing.

  16. Multipoint laser Doppler vibrometry using holographic optical elements and a CMOS digital camera.

    PubMed

    Connelly, Michael J; Szecówka, Przemyslaw M; Jallapuram, Raghavendra; Martin, Suzanne; Toal, Vincent; Whelan, Maurice P

    2008-02-15

    A laser Doppler vibrometer (LDV) is described in which holographic optical elements are used to provide the interferometer reference and object illumination beams. A complementary metal-oxide semiconductor camera, incorporating a digital signal processor, is used to carry out real-time signal processing of the interferometer output to allow multipoint LDV to be implemented.

  17. Analysis of Transitional and Turbulent Flow Through the FDA Benchmark Nozzle Model Using Laser Doppler Velocimetry.

    PubMed

    Taylor, Joshua O; Good, Bryan C; Paterno, Anthony V; Hariharan, Prasanna; Deutsch, Steven; Malinauskas, Richard A; Manning, Keefe B

    2016-09-01

    Transitional and turbulent flow through a simplified medical device model is analyzed as part of the FDA's Critical Path Initiative, designed to improve the process of bringing medical products to market. Computational predictions are often used in the development of devices and reliable in vitro data is needed to validate computational results, particularly estimations of the Reynolds stresses that could play a role in damaging blood elements. The high spatial resolution of laser Doppler velocimetry (LDV) is used to collect two component velocity data within the FDA benchmark nozzle model. Two flow conditions are used to produce flow encompassing laminar, transitional, and turbulent regimes, and viscous stresses, principal Reynolds stresses, and turbulence intensities are calculated from the measured LDV velocities. Axial velocities and viscous stresses are compared to data from a prior inter-laboratory study conducted with particle image velocimetry. Large velocity gradients are observed near the wall in the nozzle throat and in the jet shear layer located in the expansion downstream of the throat, with axial velocity changing as much as 4.5 m/s over 200 μm. Additionally, maximum Reynolds shear stresses of 1000-2000 Pa are calculated in the high shear regions, which are an order of magnitude higher than the peak viscous shear stresses (<100 Pa). It is important to consider the effects of both viscous and turbulent stresses when simulating flow through medical devices. Reynolds stresses above commonly accepted hemolysis thresholds are measured in the nozzle model, indicating that hemolysis may occur under certain flow conditions. As such, the presented turbulence quantities from LDV, which are also available for download at https://fdacfd.nci.nih.gov/ , provide an ideal validation test for computational simulations that seek to characterize the flow field and to predict hemolysis within the FDA nozzle geometry. PMID:27350137

  18. Functionalization and characterization of persistent luminescence nanoparticles by dynamic light scattering, laser Doppler and capillary electrophoresis.

    PubMed

    Ramírez-García, Gonzalo; d'Orlyé, Fanny; Gutiérrez-Granados, Silvia; Martínez-Alfaro, Minerva; Mignet, Nathalie; Richard, Cyrille; Varenne, Anne

    2015-12-01

    Zinc gallate nanoparticles doped with chromium (III) (ZnGa1.995O4:Cr0.005) are innovative persistent luminescence materials with particular optical properties allowing their use for in vivo imaging. They can be excited in the tissue transparency window by visible photons and emit light for hours after the end of the excitation. This allows to observe the probe without any time constraints and without autofluorescence signals produced by biological tissues. Modification of the surface of these nanoparticles is essential to be colloidally stable not only for cell targeting applications but also for proper distribution in living organisms. The use of different methods for controlling and characterizing the functionalization process is imperative to better understand the subsequent interactions with biological elements. This work explores for the first time the characterization and optimization of a classic functionalization sequence, starting with hydroxyl groups (ZGO-OH) at the nanoparticle surface, followed by an aminosilane-functionalization intermediate stage (ZGO-NH2) before PEGylation (ZGO-PEG). Dynamic light scattering and laser doppler electrophoresis were used in combination with capillary electrophoresis to characterize the nanoparticle functionalization processes and control their colloidal and chemical stability. The hydrodynamic diameter, zeta potential, electrophoretic mobility, stability over time and aggregation state of persistent luminescence nanoparticles under physiological-based solution conditions have been studied for each functional state. Additionally, a new protocol to improve ZGO-NH2 stability based on a thermal treatment to complete covalent binding of (3-aminopropyl) triethoxysilane onto the particle surface has been optimized. This thorough control increases our knowledge on these nanoparticles for subsequent toxicological studies and ultimately medical application.

  19. Functionalization and characterization of persistent luminescence nanoparticles by dynamic light scattering, laser Doppler and capillary electrophoresis.

    PubMed

    Ramírez-García, Gonzalo; d'Orlyé, Fanny; Gutiérrez-Granados, Silvia; Martínez-Alfaro, Minerva; Mignet, Nathalie; Richard, Cyrille; Varenne, Anne

    2015-12-01

    Zinc gallate nanoparticles doped with chromium (III) (ZnGa1.995O4:Cr0.005) are innovative persistent luminescence materials with particular optical properties allowing their use for in vivo imaging. They can be excited in the tissue transparency window by visible photons and emit light for hours after the end of the excitation. This allows to observe the probe without any time constraints and without autofluorescence signals produced by biological tissues. Modification of the surface of these nanoparticles is essential to be colloidally stable not only for cell targeting applications but also for proper distribution in living organisms. The use of different methods for controlling and characterizing the functionalization process is imperative to better understand the subsequent interactions with biological elements. This work explores for the first time the characterization and optimization of a classic functionalization sequence, starting with hydroxyl groups (ZGO-OH) at the nanoparticle surface, followed by an aminosilane-functionalization intermediate stage (ZGO-NH2) before PEGylation (ZGO-PEG). Dynamic light scattering and laser doppler electrophoresis were used in combination with capillary electrophoresis to characterize the nanoparticle functionalization processes and control their colloidal and chemical stability. The hydrodynamic diameter, zeta potential, electrophoretic mobility, stability over time and aggregation state of persistent luminescence nanoparticles under physiological-based solution conditions have been studied for each functional state. Additionally, a new protocol to improve ZGO-NH2 stability based on a thermal treatment to complete covalent binding of (3-aminopropyl) triethoxysilane onto the particle surface has been optimized. This thorough control increases our knowledge on these nanoparticles for subsequent toxicological studies and ultimately medical application. PMID:26409685

  20. Analysis of Transitional and Turbulent Flow Through the FDA Benchmark Nozzle Model Using Laser Doppler Velocimetry.

    PubMed

    Taylor, Joshua O; Good, Bryan C; Paterno, Anthony V; Hariharan, Prasanna; Deutsch, Steven; Malinauskas, Richard A; Manning, Keefe B

    2016-09-01

    Transitional and turbulent flow through a simplified medical device model is analyzed as part of the FDA's Critical Path Initiative, designed to improve the process of bringing medical products to market. Computational predictions are often used in the development of devices and reliable in vitro data is needed to validate computational results, particularly estimations of the Reynolds stresses that could play a role in damaging blood elements. The high spatial resolution of laser Doppler velocimetry (LDV) is used to collect two component velocity data within the FDA benchmark nozzle model. Two flow conditions are used to produce flow encompassing laminar, transitional, and turbulent regimes, and viscous stresses, principal Reynolds stresses, and turbulence intensities are calculated from the measured LDV velocities. Axial velocities and viscous stresses are compared to data from a prior inter-laboratory study conducted with particle image velocimetry. Large velocity gradients are observed near the wall in the nozzle throat and in the jet shear layer located in the expansion downstream of the throat, with axial velocity changing as much as 4.5 m/s over 200 μm. Additionally, maximum Reynolds shear stresses of 1000-2000 Pa are calculated in the high shear regions, which are an order of magnitude higher than the peak viscous shear stresses (<100 Pa). It is important to consider the effects of both viscous and turbulent stresses when simulating flow through medical devices. Reynolds stresses above commonly accepted hemolysis thresholds are measured in the nozzle model, indicating that hemolysis may occur under certain flow conditions. As such, the presented turbulence quantities from LDV, which are also available for download at https://fdacfd.nci.nih.gov/ , provide an ideal validation test for computational simulations that seek to characterize the flow field and to predict hemolysis within the FDA nozzle geometry.

  1. Development and testing of laser Doppler system components for wake vortex monitoring. Volume 2: Scanner operations manual

    NASA Technical Reports Server (NTRS)

    Edwards, B. B.; Coffey, E. W.

    1974-01-01

    The theory and operation of the scanner portion of the laser Doppler system for detecting and monitoring aircraft trailing vortices in an airport environment are discussed. Schematics, wiring diagrams, component values, and operation and checkout procedures are included.

  2. [Laser Doppler flowmetry in newborn infants with low birth weight. The effect of differences in humidity on peripheral circulation].

    PubMed

    Hanssler, L; Roll, C; Breukmann, H

    1992-01-01

    In a group of 10 low birth weight infants we measured skin temperature using infrared thermography and laser Doppler flow in central and peripheral regions of the body. After elevation of incubator humidity from 40 to 80% skin temperature of the foot rose significantly (p less than 0.01). At the same time there was a significant increase (p less than 0.05) of laser Doppler flow. Temperature and laser Doppler flow in the area of the abdomen did not show significant changes. Low birth weight infants are able to regulate peripheral blood flow after changes of ambient humidity. With the method of laser Doppler flowmetry thermoregulatory responses in the microvascular bed can be measured in these infants.

  3. Ankle-brachial pressure index estimated by laser Doppler in patients suffering from peripheral arterial obstructive disease.

    PubMed

    Ludyga, Tomasz; Kuczmik, Waclaw B; Kazibudzki, Marek; Nowakowski, Przemyslaw; Orawczyk, Tomasz; Glanowski, Michal; Kucharzewski, Marcin; Ziaja, Damion; Szaniewski, Krzysztof; Ziaja, Krzysztof

    2007-07-01

    Ankle-brachial index (ABI) measurements are widely used for evaluating the functional state of circulation in the lower limbs. However, there is some evidence that the value of ABI does not accurately reflect the degree of walking impairment in symptomatic patients with peripheral arterial obstructive disease (PAOD). We investigated the diagnostic value of ABI estimated by means of laser Doppler flowmetry (IT) for evaluating limb ischemia. We wanted to know whether laser Doppler could be more sensitive than the Doppler method in predicting walking capacity in patients with stable intermittent claudication. We analyzed a group of 30 patients with intermittent claudication (Fontain II, II/III) who were admitted for reconstructive treatment. There were 21 men and 9 women, aged 46-74 (mean 61) years. All patients underwent the treadmill test, and pain-free walking distances were measured. In each patient, we measured ABI using the two different methods: Doppler ultrasound device (ABI-Doppler) and laser Doppler (ABI-laser Doppler). The claudication distances were 25-200 m (mean 73 +/- 50.2 m). ABI-Doppler was 0.2-0.7 (0.582 +/- 0.195). ABI-laser Doppler measurements were 0.581 (+/-0.218). A correlation was found between ABI-Doppler and claudication distance (r = 0.46, P = 0.009). Also, ABI-laser Doppler values significantly correlated with claudication distances (r = 0.536, P = 0.002). The ABI evaluated by laser Doppler correlated well with claudication distances in patients with PAOD. Comparison of Doppler and laser Doppler measurements used for determining ABI showed that both methods have similar predictive power for walking capacity; however, higher correlation was observed between claudication distances and ABI measured by laser Doppler flowmetry. ABI-laser Doppler measurements are easier, are quicker, and seem to be better suited for noncompliant patients. Further investigation should be undertaken to determine whether laser Doppler is superior to the Doppler

  4. An automated method for analysis and visualization of laser Doppler velocimetry data.

    PubMed

    Healy, T M; Ellis, J T; Fontaine, A A; Jarrett, C A; Yoganathan, A P

    1997-01-01

    The analysis and visualization of large data sets collected by use of laser Doppler velocimetry has presented a challenge to researchers using this technique to investigate complex flow fields. This paper describes an automated procedure for analysis and animation of two- and three-dimensional laser Doppler velocimetry data. The procedure consists of a suite of FORTRAN programs for calculating phase window averages of velocity and the Reynolds stress tensor, calculating the principal normal stresses, maximum shear stresses, and preparation of data files for input into Plot-3D compatible data visualization software. An example application of these techniques to data collected from an in vitro investigation of the retrograde flow field associated with a bileaflet mechanical heart valve is also presented. PMID:9084838

  5. Laser Doppler velocimetry based on the photoacoustic effect in a CO{sub 2} laser

    SciTech Connect

    Choi, Jong-woon; Yu, Moon-jong; Kopica, Mirek; Woo, Sam-yong; Choi, Yong-Seok

    2005-02-01

    We report a simple laser Doppler velocimeter in which the photoacoustic effect was used to measure the rotation wheel speed. A Doppler signal, caused by mixing a returning wave with an originally existing wave inside the CO{sub 2} laser cavity, was detected using a microphone in the laser tube. Frequency of the microphone output was in proportion to the rotation speed of a wheel and is dependent on the cosine of the angle between the direction of the laser beam and tangent of wheel velocity. A Doppler-shifted frequency as high as 34 kHz was detected using this method. A frequency response of a few megahertz is expected from the laser Doppler velocimeter based on the photoacoustic effect in a CO{sub 2} laser by using a wider bandwidth microphone.

  6. Accurate flexural spring constant calibration of colloid probe cantilevers using scanning laser Doppler vibrometry.

    PubMed

    Gates, Richard S; Osborn, William A; Shaw, Gordon A

    2015-06-12

    Calibration of the flexural spring constant for atomic force microscope (AFM) colloid probe cantilevers provides significant challenges. The presence of a large attached spherical added mass complicates many of the more common calibration techniques such as reference cantilever, Sader, and added mass. Even the most promising option, AFM thermal calibration, can encounter difficulties during the optical lever sensitivity measurement due to strong adhesion and friction between the sphere and a surface. This may cause buckling of the end of the cantilever and hysteresis in the approach-retract curves resulting in increased uncertainty in the calibration. Most recently, a laser Doppler vibrometry thermal method has been used to accurately calibrate the normal spring constant of a wide variety of tipped and tipless commercial cantilevers. This paper describes a variant of the technique, scanning laser Doppler vibrometry, optimized for colloid probe cantilevers and capable of spring constant calibration uncertainties near ±1%.

  7. Side effects of laser-tissue interaction studied by laser Doppler vibrometry

    NASA Astrophysics Data System (ADS)

    Foth, Hans-Jochen; Meyer, Dirk H.; Stoeckel, Thomas

    2000-05-01

    Mechanical effects that amy damage tissue were measured by laser doppler vibrometry. The results on the recoil momentum illustrate the laser parameters under which laser survey of organs with delicate structures becomes dangerous. One example is the acceleration of the tiny middle ear bones. In the case of an intact ossicular chain, the motion of a middle ear bone is transferred to the inner ear. The second topic is related to eye surgery. Removing or cutting of membranes, the lens or the vitreous body by pulsed lasers is often associated with the formation of laser induced cavitation bubbles. The collapse of these bubbles generates pressure shock waves propagation through the eye. Laser Doppler vibrometry was used to monitor the shock wave induced velocity of the sclera.

  8. [Laser Doppler vibrometry: a new tool for diagnosing hearing loss with an intact eardrum].

    PubMed

    Turcanu, Diana; Mârţu, D; Dalhoff, E; Gummer, A W

    2006-01-01

    The diagnosis of hearing loss with an intact eardrum frequently requires an entire battery of hearing tests, without the guarantee of an exact diagnosis. The techniques frequently provide only orientation for it, without establishing the site of the lesion and the etiology of the hearing loss. Laser Doppler vibrometry is a new technique, which has recently proved capable, of partially resolving this problem. The method is based on the study of the sound-induced vibration of the eardrum in humans in vivo, using a laser Doppler vibrometer. The method proved to be useful in the diagnosis of the pathology of the middle ear sound transmission system, avoiding the need for exploratory tympanotomy. Called "laser-audiometry", the method promises to become a new diagnostic tool for hearing impairment.

  9. Optical characteristics of modified fiber tips in single fiber, laser Doppler flowmetry

    NASA Astrophysics Data System (ADS)

    Oberg, P. Ake; Cai, Hongming; Rohman, Hakan; Larsson, Sven-Erik

    1994-02-01

    Percutaneous laser Doppler flowmetry (LDF) and bipolar surface electromyography (EMG) were used simultaneously for measurement of skeletal muscle (trapezius) perfusion in relation to static load and fatigue. On-line computer (386 SX) processing of the LDF- and EMG- signals made possible interpretation of the relationship between the perfusion and the activity of the muscle. The single fiber laser Doppler technique was used in order to minimize the trauma. A ray-tracing program was developed in the C language by which the optical properties of the fiber and fiber ends could be simulated. Isoirradiance graphs were calculated for three fiber end types and the radiance characteristics were measured for each fiber end. The three types of fiber-tips were evaluated and compared in flow model measurements.

  10. Model studies of blood flow in basilar artery with 3D laser Doppler anemometer

    NASA Astrophysics Data System (ADS)

    Frolov, S. V.; Sindeev, S. V.; Liepsch, D.; Balasso, A.; Proskurin, S. G.; Potlov, A. Y.

    2015-03-01

    It is proposed an integrated approach to the study of basilar artery blood flow using 3D laser Doppler anemometer for identifying the causes of the formation and development of cerebral aneurysms. Feature of the work is the combined usage of both mathematical modeling and experimental methods. Described the experimental setup and the method of measurement of basilar artery blood flow, carried out in an interdisciplinary laboratory of Hospital Rechts der Isar of Technical University of Munich. The experimental setup used to simulate the blood flow in the basilar artery and to measure blood flow characteristics using 3D laser Doppler anemometer (3D LDA). Described a method of numerical studies carried out in Tambov State Technical University and the Bakoulev Center for Cardiovascular Surgery. Proposed an approach for sharing experimental and numerical methods of research to identify the causes of the basilar artery aneurysms.

  11. A full field, 3-D velocimeter for microgravity crystallization experiments

    NASA Technical Reports Server (NTRS)

    Brodkey, Robert S.; Russ, Keith M.

    1991-01-01

    The programming and algorithms needed for implementing a full-field, 3-D velocimeter for laminar flow systems and the appropriate hardware to fully implement this ultimate system are discussed. It appears that imaging using a synched pair of video cameras and digitizer boards with synched rails for camera motion will provide a viable solution to the laminar tracking problem. The algorithms given here are simple, which should speed processing. On a heavily loaded VAXstation 3100 the particle identification can take 15 to 30 seconds, with the tracking taking less than one second. It seeems reasonable to assume that four image pairs can thus be acquired and analyzed in under one minute.

  12. Laser Doppler flowmetry: an aid in differential diagnosis of apical radiolucencies.

    PubMed

    Chandler, N P; Love, R M; Sundqvist, G

    1999-05-01

    The case of a patient having 2 teeth with associated apical radiolucencies that responded to conventional pulp tests is presented. A decision was made to reexamine the patient at intervals rather than perform root canal treatment. During a recall visit, use of an available laser Doppler flowmeter allowed detection of blood flow within the affected teeth. A diagnosis of periapical cemental dysplasia (cementoma) was made. PMID:10348523

  13. Laser Doppler, velocimeter system for turbine stator cascade studies and analysis of statistical biasing errors

    NASA Technical Reports Server (NTRS)

    Seasholtz, R. G.

    1977-01-01

    A laser Doppler velocimeter (LDV) built for use in the Lewis Research Center's turbine stator cascade facilities is described. The signal processing and self contained data processing are based on a computing counter. A procedure is given for mode matching the laser to the probe volume. An analysis is presented of biasing errors that were observed in turbulent flow when the mean flow was not normal to the fringes.

  14. Laser Doppler flowmetry for measurement of laminar capillary blood flow in the horse

    NASA Astrophysics Data System (ADS)

    Adair, Henry S., III

    1998-07-01

    Current methods for in vivo evaluation of digital hemodynamics in the horse include angiography, scintigraphy, Doppler ultrasound, electromagnetic flow and isolated extracorporeal pump perfused digit preparations. These techniques are either non-quantifiable, do not allow for continuous measurement, require destruction of the horse orare invasive, inducing non- physiologic variables. In vitro techniques have also been reported for the evaluation of the effects of vasoactive agents on the digital vessels. The in vitro techniques are non-physiologic and have evaluated the vasculature proximal to the coronary band. Lastly, many of these techniques require general anesthesia or euthanasia of the animal. Laser Doppler flowmetry is a non-invasive, continuous measure of capillary blood flow. Laser Doppler flowmetry has been used to measure capillary blood flow in many tissues. The principle of this method is to measure the Doppler shift, that is, the frequency change that light undergoes when reflected by moving objects, such as red blood cells. Laser Doppler flowmetry records a continuous measurement of the red cell motion in the outer layer of the tissue under study, with little or no influence on physiologic blood flow. This output value constitutes the flux of red cells and is reported as capillary perfusion units. No direct information concerning oxygen, nutrient or waste metabolite exchange in the surrounding tissue is obtained. The relationship between the flowmeter output signal and the flux of red blood cells is linear. The principles of laser Doppler flowmetry will be discussed and the technique for laminar capillary blood flow measurements will be presented.

  15. Laser Doppler flowmetry and cardiac output in critically ill surgical patients.

    PubMed

    Eyer, S; Borgos, J; Strate, R G

    1987-08-01

    Laser Doppler flowmetry (LDF) accurately measures cutaneous microcirculatory blood flow. We compared change in LDF flow to change in thermodilution cardiac output in ten critically ill surgical patients. A subset analysis of three patients with low cardiac output (cardiac index less than 2 L/min X m2) showed no correlation. We conclude that, under these study conditions, LDF microcirculatory flow did not reflect macrocirculatory flow. We conjecture that overcoming cutaneous vasoregulation with thermal vasodilation may obviate these results.

  16. Realization of fiber-based laser Doppler vibrometer with serrodyne frequency shifting.

    PubMed

    Li, Yanlu; Meersman, Stijn; Baets, Roel

    2011-06-10

    We demonstrate a laser Doppler vibrometer (LDV) based on the serrodyne frequency shifting technique. A proof-of-principle system is implemented on the basis of fiber-optic components but opens the way toward an ultracompact integrated LDV system on a silicon chip. With a low laser power of 50  μW, the serrodyne LDV was able to measure submicrometer vibrations with frequencies in the audio range.

  17. Laser Doppler vibrometry experiment on a piezo-driven slot synthetic jet in water

    NASA Astrophysics Data System (ADS)

    Broučková, Zuzana; Vít, Tomáš; Trávníček, Zdeněk

    2015-05-01

    The present study deals with a slot synthetic jet (SJ) issuing from an actuator into quiescent surroundings and driven by a piezoceramic transducer. The actuator slot width was 0.36 mm, with a drive frequency proposed near the theoretical natural frequency of the actuator. The working fluid was water at room temperature. The present experiments used flow visualization (a laser-induced fluorescence technique) and laser Doppler vibrometry methods. Flow visualization was used to identify SJ formation, to demonstrate its function, and to estimate SJ velocity. Laser Doppler vibrometry was used to quantify diaphragm displacement and refine operating parameters. Phase averaging yielded a spatial and temporal diaphragm deflection during the actuation period. Taking incompressibility and continuity into consideration, the velocity in the actuator slot and the Reynolds number of the SJ were evaluated as 0.21 m/s and 157, respectively. The present results confirmed a SJ actuator function at the resonance frequency of approximately 46 Hz, which corresponds closely with the theoretical evaluation. The laser Doppler vibrometry results corresponded closely with an estimation of SJ velocity by the present flow visualization.

  18. A new laser Doppler flowmeter prototype for depth dependent monitoring of skin microcirculation

    NASA Astrophysics Data System (ADS)

    Figueiras, E.; Campos, R.; Semedo, S.; Oliveira, R.; Requicha Ferreira, L. F.; Humeau-Heurtier, A.

    2012-03-01

    Laser Doppler flowmetry (LDF) is now commonly used in clinical research to monitor microvascular blood flow. However, the dependence of the LDF signal on the microvascular architecture is still unknown. That is why we propose a new laser Doppler flowmeter for depth dependent monitoring of skin microvascular perfusion. This new laser Doppler flowmeter combines for the first time, in a device, several wavelengths and different spaced detection optical fibres. The calibration of the new apparatus is herein presented together with in vivo validation. Two in vivo validation tests are performed. In the first test, signals collected in the ventral side of the forearm are analyzed; in the second test, signals collected in the ventral side of the forearm are compared with signals collected in the hand palm. There are good indicators that show that different wavelengths and fibre distances probe different skin perfusion layers. However, multiple scattering may affect the results, namely the ones obtained with the larger fibre distance. To clearly understand the wavelength effect in LDF measurements, other tests have to be performed.

  19. A new laser Doppler flowmeter prototype for depth dependent monitoring of skin microcirculation.

    PubMed

    Figueiras, E; Campos, R; Semedo, S; Oliveira, R; Requicha Ferreira, L F; Humeau-Heurtier, A

    2012-03-01

    Laser Doppler flowmetry (LDF) is now commonly used in clinical research to monitor microvascular blood flow. However, the dependence of the LDF signal on the microvascular architecture is still unknown. That is why we propose a new laser Doppler flowmeter for depth dependent monitoring of skin microvascular perfusion. This new laser Doppler flowmeter combines for the first time, in a device, several wavelengths and different spaced detection optical fibres. The calibration of the new apparatus is herein presented together with in vivo validation. Two in vivo validation tests are performed. In the first test, signals collected in the ventral side of the forearm are analyzed; in the second test, signals collected in the ventral side of the forearm are compared with signals collected in the hand palm. There are good indicators that show that different wavelengths and fibre distances probe different skin perfusion layers. However, multiple scattering may affect the results, namely the ones obtained with the larger fibre distance. To clearly understand the wavelength effect in LDF measurements, other tests have to be performed.

  20. UV laser-induced fluorescence spectroscopy and laser Doppler flowmetry in the diagnostics of alopecia

    NASA Astrophysics Data System (ADS)

    Skomorokha, Diana P.; Pigoreva, Yulia N.; Salmin, Vladimir V.

    2016-04-01

    Development of optical biopsy methods has a great interest for medical diagnostics. In clinical and experimental studies it is very important to analyze blood circulation quickly and accurately, thereby laser Doppler flowmetry (LDF) is widely used. UV laser-induced fluorescence spectroscopy (UV LIFS) is express highly sensitive and widely-spread method with no destructive impact, high excitation selectivity and the possibility to use in highly scattering media. The goal of this work was to assess a correlation of UV laser-induced fluorescence spectroscopy and laser Doppler flowmetry parameters, and a possibility to identify or to differentiate various types of pathological changes in tissues according to their autofluorescence spectra. Three groups of patients with diffuse (symptomatic) alopecia, androgenic alopecia, and focal alopecia have been tested. Each groups consisted of not less than 20 persons. The measurements have been done in the parietal and occipital regions of the sculls. We used the original automated spectrofluorimeter to record autofluorescence spectra, and standard laser Doppler flowmeter BLF-21 (Transonic Systems, Inc., USA) to analyze the basal levels of blood circulation. Our results show that UV LIFS accurately distinguishes the zones with different types of alopecia. We found high correlation of the basal levels of blood circulation and the integrated intensity of autofluorescence in the affected tissue.

  1. Ultrahigh-resolution full-field optical coherence tomography.

    PubMed

    Dubois, Arnaud; Grieve, Kate; Moneron, Gael; Lecaque, Romain; Vabre, Laurent; Boccara, Claude

    2004-05-10

    We have developed a white-light interference microscope for ultrahigh-resolution full-field optical coherence tomography of biological media. The experimental setup is based on a Linnik-type interferometer illuminated by a tungsten halogen lamp. En face tomographic images are calculated by a combination of interferometric images recorded by a high-speed CCD camera. Spatial resolution of 1.8 microm x 0.9 microm (transverse x axial) is achieved owing to the extremely short coherence length of the source, the compensation of dispersion mismatch in the interferometer arms, and the use of relatively high-numerical-aperture microscope objectives. A shot-noise-limited detection sensitivity of 90 dB is obtained in an acquisition time per image of 4 s. Subcellular-level images of plant, animal, and human tissues are presented. PMID:15143811

  2. Evaluation of algorithms for microperfusion assessment by fast simulations of laser Doppler power spectral density.

    PubMed

    Wojtkiewicz, S; Liebert, A; Rix, H; Maniewski, R

    2011-12-21

    In classical laser Doppler (LD) perfusion measurements, zeroth- and first-order moments of the power spectral density of the LD signal are utilized for the calculation of a signal corresponding to the concentration, speed and flow of red blood cells (RBCs). We have analysed the nonlinearities of the moments in relation to RBC speed distributions, parameters of filters utilized in LD instruments and the signal-to-noise ratio. We have developed a new method for fast simulation of the spectrum of the LD signal. The method is based on a superposition of analytically calculated Doppler shift probability distributions derived for the assumed light scattering phase function. We have validated the method by a comparison of the analytically calculated spectra with results of Monte Carlo (MC) simulations. For the semi-infinite, homogeneous medium and the single Doppler scattering regime, the analytical calculation describes LD spectra with the same accuracy as the MC simulation. The method allows for simulating the LD signal in time domain and furthermore analysing the index of perfusion for the assumed wavelength of the light, optical properties of the tissue and concentration of RBCs. Fast simulations of the LD signal in time domain and its frequency spectrum can be utilized in applications where knowledge of the LD photocurrent is required, e.g. in the development of detectors for tissue microperfusion monitoring or in measurements of the LD autocorrelation function for perfusion measurements. The presented fast method for LD spectra calculation can be used as a tool for evaluation of signal processing algorithms used in the LD method and/or for the development of new algorithms of the LD flowmetry and imaging. We analysed LD spectra obtained by analytical calculations using a classical algorithm applied in classical LD perfusion measurements. We observed nonlinearity of the first moment M₁ for low and high speeds of particles (v < 2 mm s⁻¹, v > 10 mm s⁻¹). It was

  3. Evaluation of algorithms for microperfusion assessment by fast simulations of laser Doppler power spectral density

    NASA Astrophysics Data System (ADS)

    Wojtkiewicz, S.; Liebert, A.; Rix, H.; Maniewski, R.

    2011-12-01

    In classical laser Doppler (LD) perfusion measurements, zeroth- and first-order moments of the power spectral density of the LD signal are utilized for the calculation of a signal corresponding to the concentration, speed and flow of red blood cells (RBCs). We have analysed the nonlinearities of the moments in relation to RBC speed distributions, parameters of filters utilized in LD instruments and the signal-to-noise ratio. We have developed a new method for fast simulation of the spectrum of the LD signal. The method is based on a superposition of analytically calculated Doppler shift probability distributions derived for the assumed light scattering phase function. We have validated the method by a comparison of the analytically calculated spectra with results of Monte Carlo (MC) simulations. For the semi-infinite, homogeneous medium and the single Doppler scattering regime, the analytical calculation describes LD spectra with the same accuracy as the MC simulation. The method allows for simulating the LD signal in time domain and furthermore analysing the index of perfusion for the assumed wavelength of the light, optical properties of the tissue and concentration of RBCs. Fast simulations of the LD signal in time domain and its frequency spectrum can be utilized in applications where knowledge of the LD photocurrent is required, e.g. in the development of detectors for tissue microperfusion monitoring or in measurements of the LD autocorrelation function for perfusion measurements. The presented fast method for LD spectra calculation can be used as a tool for evaluation of signal processing algorithms used in the LD method and/or for the development of new algorithms of the LD flowmetry and imaging. We analysed LD spectra obtained by analytical calculations using a classical algorithm applied in classical LD perfusion measurements. We observed nonlinearity of the first moment M1 for low and high speeds of particles (v < 2 mm s-1, v > 10 mm s-1). It was also

  4. Nondestructive techniques for detection of delamination in ceramic tile: a laboratory comparison between IR thermal cameras and laser Doppler vibrometers

    NASA Astrophysics Data System (ADS)

    De Andrade, Roberto M.; Esposito, Enrico; Paone, Nicola; Revel, Gian M.

    1999-02-01

    In ceramic tile industry, delamination is one of the more important and difficult problems to detect. Among all the general non-destructive evaluation methods, optical inspection technique seem to be particularly suitable. A method based on acquisition and processing of IR thermal images is proposed. Measurements have been performed by artificial heating by an IR quartz lamp. The performance of the technique has been evaluated experimentally and results show that the examine defects in the measured samples have been correctly detected. Another proposed technique for detection of delaminations and voids in structures is vibration monitoring by a scanning laser doppler vibrometer (SLDV). The basic idea is that a defected area will show as a higher velocity one. Structure excitation may be performed by acoustic means, thus allowing for a remote contactless measurement system. Our tests put in evidence that IR thermal images provide a very fast defect detection method appropriate for on line applications, while SLDV results show a better geometrical definition of defects shapes.

  5. Large Field, High Resolution Full-Field Optical Coherence Tomography

    PubMed Central

    Assayag, Osnath; Antoine, Martine; Sigal-Zafrani, Brigitte; Riben, Michael; Harms, Fabrice; Burcheri, Adriano; Grieve, Kate; Dalimier, Eugénie; Le Conte de Poly, Bertrand; Boccara, Claude

    2014-01-01

    We present a benchmark pilot study in which high-resolution Full-Field Optical Coherence Tomography (FF-OCT) was used to image human breast tissue and is evaluated to assess its ability to aid the pathologist’s management of intra-operative diagnoses. FF-OCT imaging safety was investigated and agreement between FF-OCT and routinely prepared histopathological images was evaluated. The compact setup used for this study provides 1 µm3 resolution and 200 µm imaging depth, and a 2.25 cm2 specimen is scanned in about 7 minutes. 75 breast specimens were imaged from 22 patients (21 women, 1 man) with a mean age of 58 (range: 25-83). Pathologists blind diagnosed normal/benign or malignant tissue based on FF-OCT images alone, diagnosis from histopathology followed for comparison. The contrast in the FF-OCT images is generated by intrinsic tissue scattering properties, meaning that no tissue staining or preparation is required. Major architectural features and tissue structures of benign breast tissue, including adipocytes, fibrous stroma, lobules and ducts were characterized. Subsequently, features resulting from pathological modification were characterized and a diagnosis decision tree was developed. Using FF-OCT images, two breast pathologists were able to distinguish normal/benign tissue from lesional with a sensitivity of 94% and 90%, and specificity of 75% and 79% respectively. PMID:24000981

  6. Full field gas phase velocity measurements in microgravity

    NASA Technical Reports Server (NTRS)

    Griffin, Devon W.; Yanis, William

    1995-01-01

    Measurement of full-field velocities via Particle Imaging Velocimetry (PIV) is common in research efforts involving fluid motion. While such measurements have been successfully performed in the liquid phase in a microgravity environment, gas-phase measurements have been beset by difficulties with seeding and laser strength. A synthesis of techniques developed at NASA LeRC exhibits promise in overcoming these difficulties. Typical implementation of PIV involves forming the light from a pulsed laser into a sheet that is some fraction of a millimeter thick and 50 or more millimeters wide. When a particle enters this sheet during a pulse, light scattered from the particle is recorded by a detector, which may be a film plane or a CCD array. Assuming that the particle remains within the boundaries of the sheet for the second pulse and can be distinguished from neighboring particles, comparison of the two images produces an average velocity vector for the time between the pulses. If the concentration of particles in the sampling volume is sufficiently large but the particles remain discrete, a full field map may be generated.

  7. Full-field interferometry using infinity corrected optics

    NASA Astrophysics Data System (ADS)

    Charrett, T. O. H.; Tatam, R. P.

    2016-01-01

    In this paper the construction of full-field (imaging) interferometers using infinity corrected optics commonly used in microscopy is discussed, with an emphasis on self-mixing interferometry configurations where the imaged light field is mixed with itself rather than a reference wave. Such configurations are used in speckle shearing interferometry, flow visualisation and quantitative flow measurement. The critical considerations for constructing path-length imbalanced full-field interferometers for these and similar applications are discussed, expressions are derived for key calculations and interferograms from example interferometers are presented. These include the concept of balancing the infinity-spaces of the two arms via the use of a glass block to minimise the optical path difference variation across the interferogram and ensure adequate sampling of the fringes on the detector. Further, the use of tilted glass blocks in single-pass and double-pass arrangements is detailed for the generation and control of spatial carrier fringes without extensive realignment of the interferometer, and for phase shifting.

  8. Normalized Noise Power Spectrum of Full Field Digital Mammography System

    SciTech Connect

    Isa, Norriza Mohd; Wan Hassan, Wan Muhamad Saridan

    2010-01-05

    A method to measure noise power spectrum of a full field digital mammography system is presented. The effect of X-ray radiation dose, size and configuration of region of interest on normalized noise power spectrum (NNPS) was investigated. Flat field images were acquired using RQA-M2 beam quality technique (Mo/Mo anode-filter, 28 kV, 2 mm Al) with different clinical radiation doses. The images were cropped at about 4 cm from the edge of the breast wall and then divided into different size of non-overlapping or overlapping segments. NNPS was determined through detrending, 2-D fast Fourier transformation and normalization. Our measurement shows that high radiation dose gave lower NNPS at a specific beam quality.

  9. Laser Doppler flowmetry evaluation of gingival recovery response after laser treatment

    NASA Astrophysics Data System (ADS)

    Todea, Carmen; Cânjǎu, Silvana; Dodenciu, Dorin; Miron, Mariana I.; Tudor, Anca; Bǎlǎbuc, Cosmin

    2013-06-01

    This study was performed in order to evaluate in vivo the applicability of Laser Doppler Flowmetry (LDF) in recording the gingival blood flow and to assess the changes of gingival blood flow following gingival reshaping performed with Er:YAG and 980 nm diode lasers. The LDF evaluation was performed on 20 anterior teeth, which underwent reshaping of gingiva, corresponding to 5 female patients (4 anterior teeth/patient), aged between 20 and 35. One part of the mouth was treated with Er:YAG laser (LP, VLP modes, 140 - 250 mJ, 10 - 20 Hz, using cylindrical sapphire tips) and other part with 980 nm diode laser (CW, 4 W, contact mode and saline solution cooling). The gingival blood flow was monitored using a MoorLab laser Doppler equipment (Moor Instruments Ltd., Axminster, UK) with a straight optical probe, MP3b, 10 mm. The data were processed using statistical analysis software SPSS v16.0.1. The investigation showed an evident decrease in perfusion for both areas in comparison with the baseline values 24 hours after treatment. The microvascular blood flow increased significantly after 7 days in both areas but mostly in diode area (p<0.001). After 14 days for the Er:YAG area the blood perfusion returned to the initial value. The results in diode area remained at a high level after 14 days. Both lasers proved efficiency in the surgical treatment of gingival tissue. Moreover, Laser Doppler Flowmetry is adequate for recording changes in gingival blood flow following periodontal surgery.

  10. Laser Doppler flux measurement for the assessment of cutaneous microcirculatio--critical remarks.

    PubMed

    Jung, F; Leithäuser, B; Landgraf, H; Jünger, M; Franzeck, U; Pries, A; Sternitzky, R; Franke, R P; Forconi, S; Ehrly, A M

    2013-01-01

    Back scattered Laser Doppler (LD) signals are composed of two different individual signals. The number of the moving particles and the speed of the particles in the measured tissue volume determine the frequency shift and the band width of the Doppler signal. The dependence of the Laser Doppler flux on the number of scattering particles is highly nonlinear: at very low hematocrit and high speed the axial migration of the cells to the centre of the blood vessels is very strong, so that in these cases - because of the parabolic flow profile - the Doppler flux measurement overestimates the mean real blood flow (up to two- or three-fold). The opposite is the case when the hematocrit is very high, then the blood flow might be underestimated (due to the increased amounts of blood cells near the vessel wall). In addition, a very change in number of moving particles - as can occur during the postprandial phase or during therapy - can change the signal also at a constant cell number. Also, it must be mentioned that the LD signal possibly is not only reflected by moving blood cells in the different skin layers but also by blood cells flowing in tissues below the skin (particularly below atrophied skin areas of older patients) so that in such cases the LD Flux signal reflects not exclusively the skin blood flow. Therefore, LD flux at rest may still be within the normal range even in advanced states of disease, since the scattered light is sampled from a tissue volume which may contain also non-nutritive shunt vessels. This critical analysis of the LD signals of course shall not lead to an overall rejection of the application of laser Doppler systems. Actual progress only can, however, be obtained under the exact consideration of anatomical conditions, technical restrictions and when generalizations are avoided.

  11. Adaptive Model-Based Mine Detection/Localization using Noisy Laser Doppler Vibration Measurements

    SciTech Connect

    Sullivan, E J; Xiang, N; Candy, J V

    2009-04-06

    The acoustic detection of buried mines is hampered by the fact that at the frequencies required for obtaining useful penetration, the energy is quickly absorbed by the ground. A recent approach which avoids this problem, is to excite the ground with a high-level low frequency sound, which excites low frequency resonances in the mine. These resonances cause a low-level vibration on the surface which can be detected by a Laser Doppler Vibrometer. This paper presents a method of quickly and efficiently detecting these vibrations by sensing a change in the statistics of the signal when the mine is present. Results based on real data are shown.

  12. Remote measurement of wind speed using a dual beam backscatter laser Doppler velocimeter.

    PubMed

    Bartlett, K G; She, C Y

    1976-08-01

    Measurements of atmospheric wind speeds at distances up to 60 m using a dual beam laser Doppler velocimeter with digital autocorrelation analysis, an unfocused argon ion laser (0.10-0.35 W) at 5145 A, and a 20-cm collecting telescope are reported. Criteria affecting the field performance of this system and an expression giving the power and range dependence of the data accumulation rate are presented. Major improvement of the system's performance can be made by focusing the laser beams and properly restricting the field of the collecting telescope. The potential of this technique for remote wind measurement at ranges of several hundred meters is discussed.

  13. The remote measurement of tornado-like flows employing a scanning laser Doppler system

    NASA Technical Reports Server (NTRS)

    Jeffreys, H. B.; Bilbro, J. W.; Dimarzio, C.; Sonnenschein, C.; Toomey, D.

    1977-01-01

    The paper deals with a scanning laser Doppler velocimeter system employed in a test program for measuring naturally occurring tornado-like phenomena, known as dust devils. A description of the system and the test program is followed by a discussion of the data processing techniques and data analysis. The system uses a stable 15-W CO2 laser with the beam expanded and focused by a 12-inch telescope. Range resolution is obtained by focusing the optical system. The velocity of each volume of air (scanned in a horizontal plane) is determined from spectral analysis of the heterodyne signal. Results derived from the measurement program and data/system analyses are examined.

  14. Incident beam polarization for laser Doppler velocimetry employing a sapphire cylindrical window

    NASA Technical Reports Server (NTRS)

    Lock, J. A.; Schock, H. J.

    1985-01-01

    For laser Doppler velocimetry studies employing sapphire windows as optical access ports, the birefringency of sapphire produces an extra beam intersection volume which serves to effectively smear the acquired velocity flow field data. It is shown that for a cylindrical window geometry, the extra beam intersection volume may be eliminated with minimal decrease in the fringe visibility of the remaining intersection volume by suitably orienting the polarizations of the initial laser beams. For horizontally incident beams, these polarizations were measured at three intersection locations within the cylinder. It was found that the measured polarization angles agreed with the theoretical predictions.

  15. Bragg cell laser intensity modulation: effect on laser Doppler velocimetry measurements

    SciTech Connect

    Mychkovsky, Alexander G.; Chang, Natasha A.; Ceccio, Steven L.

    2009-06-20

    In most laser Doppler velocimetry (LDV) systems, the frequency of one of the two laser beams that intersect to create the probe volume is shifted with an acousto-optic element. It is shown here that Bragg shifting can impose a problematic fluctuation in intensity on the frequency-shifted beam, producing spurious velocity measurements. This fluctuation occurs at twice the Bragg cell frequency, and its relative amplitude to the time average intensity is a function of the ratio of the laser beam diameter to the Bragg cell acoustic wavelength. A physical model and a configuration procedure to minimize adverse effects of the intensity modulations are presented.

  16. Continuous scanning laser Doppler vibrometry and wavelet processing for diagnostics: A time domain approach

    NASA Astrophysics Data System (ADS)

    Chiariotti, P.; Revel, G. M.; Martarelli, M.

    2016-06-01

    Continuous Scanning Laser Doppler Vibrometry (CSLDV) is a well-known technique within the structural dynamic community. However, the whole potentials of CSLDV for diagnostic purposes have not been fully exploited yet. This paper presents a time domain approach for identifying damages in structures. The method, which is based on a wavelet processing of vibration data collected by CSLDV, does not need any a-priori knowledge of the vibration behavior of the undamaged sample. Applications on real test cases are presented and discussed in the paper, demonstrating the promising performance of the approach as a non-destructive testing technique.

  17. Significance of the follicular pathway for dermal substance penetration quantified by laser Doppler flowmetry.

    PubMed

    Vandersee, Staffan; Erdmenger, Ute; Patzelt, Alexa; Beyer, Marc; Meinke, Martina C; Darvin, Maxim E; Koscielny, Jürgen; Lademann, Jürgen

    2016-03-01

    The understanding of transdermal substance penetration pathways remains an important field for the development of future topical drugs and cosmetics. Laser Doppler flowmetry is a well-established method for evaluating cutaneous perfusion. In a study on 6 healthy male volunteers, we topically applied the vasoactive substance benzyl nicotinate on two test areas with open and obturated hair follicles and measured changes in the blood flow by Doppler flowmetry. Contrary to occluded follicles, the application onto the test area with open follicles led to a statistically significant perfusion increase within the first 5 minutes, emphasizing the importance of the follicular pathway for epidermal penetration.

  18. Homodyne laser Doppler vibrometer on silicon-on-insulator with integrated 90 degree optical hybrids.

    PubMed

    Li, Yanlu; Baets, Roel

    2013-06-01

    A miniaturized homodyne laser Doppler vibrometer (LDV) with a compact 90° optical hybrid is experimentally demonstrated on a CMOS compatible silicon-on-insulator (SOI) platform. Optical components on this platform usually have inadequate suppressions of spurious reflections, which significantly influence the performance of the LDV. Numerical compensation methods are implemented to effectively decrease the impact of these spurious reflections. With the help of these compensation methods, measurements for both super-half-wavelength and sub-half-wavelength vibrations are demonstrated. Results show that the minimal detectable velocity is around 1.2 μm/s.

  19. Laser-Doppler vibrating tube densimeter for measurements at high temperatures and pressures.

    PubMed

    Aida, Tsutomu; Yamazaki, Ai; Akutsu, Makoto; Ono, Takumi; Kanno, Akihiro; Hoshina, Taka-aki; Ota, Masaki; Watanabe, Masaru; Sato, Yoshiyuki; Smith, Richard L; Inomata, Hiroshi

    2007-11-01

    A laser-Doppler vibrometer was used to measure the vibration of a vibrating tube densimeter for measuring P-V-T data at high temperatures and pressures. The apparatus developed allowed the control of the residence time of the sample so that decomposition at high temperatures could be minimized. A function generator and piezoelectric crystal was used to excite the U-shaped tube in one of its normal modes of vibration. Densities of methanol-water mixtures are reported for at 673 K and 40 MPa with an uncertainty of 0.009 g/cm3.

  20. Measurement of the resonance frequency of single bubbles using a laser Doppler vibrometer.

    PubMed

    Argo, Theodore F; Wilson, Preston S; Palan, Vikrant

    2008-06-01

    The behavior of bubbles confined in tubes and channels is important in medical and industrial applications. In these small spaces, traditional means of experimentally observing bubble dynamics are often impossible or significantly perturb the system. A laser Doppler vibrometer (LDV) requires a narrow (<1 mm diameter) line-of-sight access for the beam and illumination of the bubble does not perturb its dynamics. LDV measurements of the resonance frequency of a bubble suspended in a small tank are presented to illustrate the utility of this measurement technique. The precision of the technique is similar to the precision of traditional acoustic techniques.

  1. Use of a laser doppler vibrometer for high frequency accelerometer characterizations

    SciTech Connect

    Bateman, V.I.; Hansche, B.D.; Solomon, O.M.

    1995-12-31

    A laser doppler vibrometer (LDV) is being used for high frequency characterizations of accelerometers at Sandia National Laboratories (SNL). A LDV with high frequency (up to 1.5 MHz) and high velocity (10 M/s) capability was purchased from a commercial source and has been certified by the Primary Electrical Standards Department at SNL. The method used for this certification and the certification results are presented. Use of the LDV for characterization of accelerometers at high frequencies and of accelerometer sensitivity to cross-axis shocks on a Hopkinson bar apparatus is discussed.

  2. Modal analysis of rotating plate using tracking laser Doppler vibrometer: algorithm modification

    NASA Astrophysics Data System (ADS)

    Khalil, Hossam; Kim, Dongkyu; Nam, Joonsik; Park, Kyihwan

    2015-07-01

    A modified algorithm for tracking laser Doppler vibrometer (TLDV) is introduced to measure the vibration of rotating objects. The proposed algorithm unlike the old algorithm for TLDV can be used when the speed of the object to be tracked varies continuously or alternating in a small range. The proposed algorithm is to use encoder only as a position sensor. The position from the encoder is used to calculate the driving signals to the galvanometers. To verify the proposed method, experimental modal analysis of the circular plate in stationary and rotating cases are made.

  3. Laser-Doppler vibrating tube densimeter for measurements at high temperatures and pressures

    SciTech Connect

    Aida, Tsutomu; Yamazaki, Ai; Akutsu, Makoto; Ono, Takumi; Kanno, Akihiro; Hoshina, Taka-aki; Ota, Masaki; Watanabe, Masaru; Sato, Yoshiyuki; Smith, Richard L. Jr.; Inomata, Hiroshi

    2007-11-15

    A laser-Doppler vibrometer was used to measure the vibration of a vibrating tube densimeter for measuring P-V-T data at high temperatures and pressures. The apparatus developed allowed the control of the residence time of the sample so that decomposition at high temperatures could be minimized. A function generator and piezoelectric crystal was used to excite the U-shaped tube in one of its normal modes of vibration. Densities of methanol-water mixtures are reported for at 673 K and 40 MPa with an uncertainty of 0.009 g/cm{sup 3}.

  4. Integrated laser Doppler blood flowmeter designed to enable wafer-level packaging.

    PubMed

    Kimura, Yoshinori; Goma, Masaki; Onoe, Atsushi; Higurashi, Eiji; Sawada, Renshi

    2010-08-01

    The authors propose a new sensor structure for an integrated laser Doppler blood flowmeter that consists of two silicon cavities with a PD and laser diode inside each cavity. A silicon lid formed with a converging microlens completes the package. This structure, which was achieved using micromachining techniques, features reduced optical power loss in the sensor, resulting in its small size and significantly low power consumption. Measurements using a model tissue blood flow system confirmed that the new sensor had high linearity and a wide dynamic range for measuring tissue blood flow. PMID:20199932

  5. Laser-Doppler vibrating tube densimeter for measurements at high temperatures and pressures

    NASA Astrophysics Data System (ADS)

    Aida, Tsutomu; Yamazaki, Ai; Akutsu, Makoto; Ono, Takumi; Kanno, Akihiro; Hoshina, Taka-aki; Ota, Masaki; Watanabe, Masaru; Sato, Yoshiyuki; Smith, Richard L.; Inomata, Hiroshi

    2007-11-01

    A laser-Doppler vibrometer was used to measure the vibration of a vibrating tube densimeter for measuring P-V-T data at high temperatures and pressures. The apparatus developed allowed the control of the residence time of the sample so that decomposition at high temperatures could be minimized. A function generator and piezoelectric crystal was used to excite the U-shaped tube in one of its normal modes of vibration. Densities of methanol-water mixtures are reported for at 673K and 40MPa with an uncertainty of 0.009g /cm3.

  6. Pilot Study of Laser Doppler Measurement of Flow Variability in the Microcirculation of the Palatal Mucosa.

    PubMed

    Le Bars, Pierre; Niagha, Gaston; Kouadio, Ayepa Alain; Demoersman, Julien; Roy, Elisabeth; Armengol, Valérie; Soueidan, Assem

    2016-01-01

    Background. Histopathological alterations can arise when the denture-supporting mucosa experiences microbial and mechanical stress through the denture base and diagnosis of these diseases usually follows microvascular changes. Microcirculation measurement could allow for detection of such dysfunction and aid in the early diagnosis of palatal mucosa pathologies. Materials and Methods. We tested the sensitivity of laser Doppler for measuring the microcirculation of the palatal mucosa, assessing the median raphe (MR), Schroeder area (SA), and retroincisive papilla (RP). A Doppler PeriFlux 5000 System, containing a laser diode, was used. 54 healthy participants were recruited. We compare the measurements of PU (perfusion unit) using ANOVA test. Results. The numerical values for palatal mucosa blood flow differed significantly among the anatomical areas (p = 0.0167). The mean value of Schroeder area was 92.6 (SD: 38.4) and was significantly higher than the retroincisive papilla (51.9) (SD: 20.2) (p < 0.05), which in turn was higher than that of median raphe (31.9) (SD: 24.2) (p < 0.0001). Conclusion. Schroeder area appeared to have the greatest sensitivity, and vascular flow variability among individuals was also greatest in this region. We suggest that analysis of blood stream modification with laser Doppler of the palatal mucosa can help to detect onset signs of pathological alterations.

  7. Scanning Laser Doppler Vibrometry Application to Artworks: New Acoustic and Mechanical Exciters for Structural Diagnostics

    NASA Astrophysics Data System (ADS)

    Agnani, A.; Esposito, E.

    After first attempts some years ago, the scanning laser Doppler vibrometer has become an effective way of diagnosing different types of artworks; successful applications regard frescoes, icons, mosaics, ceramic artefacts and wood inlays. Also application to historical bridges has been successfully developed and a recently approved European Commission project will see the employment of scanning laser Doppler Vibrometry (SLDV) for the dynamical characterization of ancient buildings. However, a critical issue consists in the adequate excitation of the structure under test. Moreover different types of defects and different kinds of artworks require different types of excitation, so this topic needs a deep consideration. In this work we will present two new types of exciters developed at our Department, namely an acoustic exciter and a mechanical one. Acoustic exciters allow remote non-invasive loading but are limited in the lower frequency range and in the amount of vibrational energy input into the structure. The proposed automatic tapping device based on a commercial impact hammer overcomes these problems. Also another acoustic exciter, a HyperSonic Sound (HSS) source has been evaluated, showing interesting features as regards sound radiation.

  8. Determining radiated sound power of building structures by means of laser Doppler vibrometry

    NASA Astrophysics Data System (ADS)

    Roozen, N. B.; Labelle, L.; Rychtáriková, M.; Glorieux, C.

    2015-06-01

    This paper introduces a methodology that makes use of laser Doppler vibrometry to assess the acoustic insulation performance of a building element. The sound power radiated by the surface of the element is numerically determined from the vibrational pattern, offering an alternative for classical microphone measurements. Compared to the latter the proposed analysis is not sensitive to room acoustical effects. This allows the proposed methodology to be used at low frequencies, where the standardized microphone based approach suffers from a high uncertainty due to a low acoustic modal density. Standardized measurements as well as laser Doppler vibrometry measurements and computations have been performed on two test panels, a light-weight wall and a gypsum block wall and are compared and discussed in this paper. The proposed methodology offers an adequate solution for the assessment of the acoustic insulation of building elements at low frequencies. This is crucial in the framework of recent proposals of acoustic standards for measurement approaches and single number sound insulation performance ratings to take into account frequencies down to 50 Hz.

  9. New type of embedded laser Doppler velocimeter for measurement of rotary wings boundary layer

    NASA Astrophysics Data System (ADS)

    Favier, D.; Maresca, C.; Nsi Mba, M.; Berton, E.; Agnes, A.

    1997-06-01

    An experimental method has been developed to determine the velocity profiles across the boundary layer of rotary wings. The measurement, based on laser Doppler velocimetry, has been tested on a helicopter rotor blade in hover. The main components of the prototype are embedded in an untwisted blade. The beams converging at the measurement volume, which can be moved along perpendicular to the surface, and the signals backscattered by flow particles, are collected through rotating fiber optic cables to a transmitter insuring the connection with fixed components (laser source, photomultipliers, burst spectrum analyzer, computer, etc.). Measurements, performed in a frame linked to the rotating blade for one radial distance from the rotation axis and at a chord abscissa x/c=0.25, have involved the tangential velocity component (chordwise) and the crossflow component (spanwise). The boundary layer has been explored at different rotating speeds of the blade. The accuracy of velocity components measurements has been evaluated in the region very close to the wall and far from the wall. The velocity profiles obtained in different hovering test conditions have shown the efficiency of the present embedded laser Doppler velocimeter method, which can also be applied to rotors in forward flight, wind turbines, etc. Undoubtly, the new database obtained on the rotating boundary layer will constitute an essential support for the physical models and computational works.

  10. Single-Particle Laser Doppler Anemometry at 1.55 mum.

    PubMed

    Harris, M; Pearson, G N; Ridley, K D; Karlsson, C J; Olsson, F A; Letalick, D

    2001-02-20

    We demonstrate the successful operation of a cw laser Doppler wind sensor at a wavelength of 1.55 mum. At longer ranges (>100 m) the signal conforms closely to complex Gaussian statistics, consistent with the incoherent addition of contributions from a large number of scattering aerosols. As the range is reduced, the probe volume rapidly diminishes and the signal statistics are dramatically modified. At the shortest ranges (<8 m) the signal becomes dominated by short bursts, each originating from a single particle within the measurement volume. These single-particle events can have a very high signal-to-noise ratio (SNR) because (1) the signal becomes concentrated within a small time window and (2) its bandwidth is much reduced compared with multiparticle detection. Examples of wind-signal statistics at different ranges and for a variety of atmospheric backscatter conditions are presented. Results show that single-particle-scattering events play a significant role even to ranges of ~50 m, leading to results inconsistent with complex Gaussian statistics. The potential is assessed for a low-power laser Doppler wind sensor that exploits the SNR enhancement obtained with single-particle detection.

  11. Assesment of gingival microcirculation in anterior teeth using laser Doppler flowmetry

    NASA Astrophysics Data System (ADS)

    Canjau, Silvana; Miron, Mariana I.; Todea, Carmen D.

    2016-03-01

    Introduction: Evaluating the health status of the gingival tissue represents an important objective in the daily practice. Inflammation changes the microcirculatory and micromorphological dynamics of human gingiva. Aim: The purpose of this study was to evaluate the microcirculation in subjects with moderate gingivitis and healthy gingiva by using laser Doppler flowmetry (LDF). Material and Methods: Recordings of the gingival microcirculation (GM) were taken from 20 healthy gingival sites and from 20 sites with moderate gingivitis. The gingival blood flows in the gingivitis group before treatment was significantly different from those in the healthy gingiva group. Signals were recorded with the aid of a laser Doppler MoorLab instrument VMS-LDF2 probe VP3 10 mm S/N 2482. Three consecutive determinations of the GM were registered for each site, as follows: before the initial therapy, at 24 hours after the initial therapy and then, 7 days after the initial therapy. The data were processed using the statistical analysis software SPSS v16.0.1. Results: The results of this preliminary study showed statistically significant differences among the GM values recorded before and after the initial therapy. Conclusions: LDF could be a useful, noninvasive, sensitive, reproducible, and harmless method for measuring gingival blood flow (gingival microcirculation) in humans.

  12. New method of laser doppler flowmetry signal processing in pulp vitality evaluation after teeth cosmetic treatment

    NASA Astrophysics Data System (ADS)

    Todea, Carmen; Sarpe, Amalia; Vitez, Bogdan; Draganescu, Gheorghe

    2014-01-01

    The present study aims to assess the pulp vitality before and after different tooth bleaching procedures, in order to determine the changes in pulpal microcirculation and whether they are reversible or not. Twelve volunteers were included in this study. For each volunteer, the pulpal blood flow of maxillary teeth was assessed prior to treatment using Laser Doppler Flowmetry. The "in office" bleaching technique was used 6 anterior teeth, with two different gels, a conventional one chemically activated (Group I 3teeth) and another one activated using Nd:YAG laser (Group II-3 teeth). The bleaching agents were applied on counterpart teeth and, after obtaining a esthetic results for each tooth, the pulpal blood flow was assessed using Laser Doppler Flowmetry immediately after treatment and then after one day and one week. All data were collected and statistically analyzed. Immediately after treatment, the assessment showed an increase of pulpal blood flow, for both study groups, but higher in Group I as compared to Group II (p<0.005). The subsequent assessments showed a reduction of the pulpal blood flow with non - significant differences between the study groups (p<0.005).The results suggest that the tooth bleaching procedurere presents a safe treatment method, which does not lead to irreversible damage to the dental pulp, when used correctly.

  13. Surface wave measurements using a single continuously scanning laser Doppler vibrometer: application to elastography.

    PubMed

    Salman, Muhammad; Sabra, Karim G

    2013-03-01

    A continuous scanning laser Doppler vibrometry (CSLDV) obtained sweeping a single laser beam along a periodic scan pattern allows measuring surface vibrations at many points simultaneously by demultiplexing the CSLDV signal. This known method fundamentally differs from conventional scanning laser vibrometry techniques in which the laser beam is kept at a fixed point during each measurement and then moved to a new position prior to the next measurement. This article demonstrates the use of a CSLDV for measuring in a non-contact fashion the velocity of low-frequency surface waves (f < 100 Hz) propagating over soft materials, namely here gel surfaces-mimicking human body soft tissues-and skeletal muscles, to develop an affordable and noninvasive elastography modality. The CSLDV vibration measurements obtained with a single laser beam, linearly scanned over the test surface at 200 Hz over lengths up to 6 cm, were validated using an array of three fixed laser Doppler vibrometers distributed along the same scan line. Furthermore, this CSLDV setup was used to measure the increase in surface wave velocity over the biceps brachii muscle which was directly correlated to the actual stiffening of the biceps occurring while a subject was performing voluntary contractions at an increasing level.

  14. Pilot Study of Laser Doppler Measurement of Flow Variability in the Microcirculation of the Palatal Mucosa

    PubMed Central

    Le Bars, Pierre; Niagha, Gaston; Kouadio, Ayepa Alain; Demoersman, Julien; Roy, Elisabeth; Armengol, Valérie; Soueidan, Assem

    2016-01-01

    Background. Histopathological alterations can arise when the denture-supporting mucosa experiences microbial and mechanical stress through the denture base and diagnosis of these diseases usually follows microvascular changes. Microcirculation measurement could allow for detection of such dysfunction and aid in the early diagnosis of palatal mucosa pathologies. Materials and Methods. We tested the sensitivity of laser Doppler for measuring the microcirculation of the palatal mucosa, assessing the median raphe (MR), Schroeder area (SA), and retroincisive papilla (RP). A Doppler PeriFlux 5000 System, containing a laser diode, was used. 54 healthy participants were recruited. We compare the measurements of PU (perfusion unit) using ANOVA test. Results. The numerical values for palatal mucosa blood flow differed significantly among the anatomical areas (p = 0.0167). The mean value of Schroeder area was 92.6 (SD: 38.4) and was significantly higher than the retroincisive papilla (51.9) (SD: 20.2) (p < 0.05), which in turn was higher than that of median raphe (31.9) (SD: 24.2) (p < 0.0001). Conclusion. Schroeder area appeared to have the greatest sensitivity, and vascular flow variability among individuals was also greatest in this region. We suggest that analysis of blood stream modification with laser Doppler of the palatal mucosa can help to detect onset signs of pathological alterations. PMID:27340663

  15. Fractal Dimension Characterization of in-vivo Laser Doppler Flowmetry signals

    NASA Astrophysics Data System (ADS)

    Srinivasan, Gayathri; Sujatha, N.

    Laser Doppler Blood Flow meter uses tissue backscattered light to non-invasively assess the blood flow rate. qualitatively. As there is large spatial variability and the temporal heterogeneity in tissue microvasculature, the measured blood flow rate is expressed in relative units. A non-linear approach in order to understand the dynamics of the microcirculation led to the fractal characterization of the blood flow signals. The study presented in the paper aims to analyze the fractal behavior of Laser Doppler Flow (LDF) signals and to quantitatively estimate the fractal dimension of waveforms using Box-Counting method. The measured Fractal dimension is an estimate of temporal variability of tissue perfusion. The rate at which fractal dimension varies as a function of location between individuals, exhibits a weak correlation with time. Further studies with a larger number of subjects are necessary to test the generality of the findings and if changes in dimension are reproducible in given individuals. In conclusion, the fractal dimension determined by Box-counting method may be useful for characterizing LDF time series signals. Future experiments evaluating whether the technique can be used to quantify microvascular dysfunction, as commonly occurring in conditions such as Diabetes, Raynaud's phenomenon, Erythromelalgia and Achenbach syndrome needs to be evaluated.

  16. Simultaneous measurement of respiration and cardiac period in preterm infants by laser Doppler vibrometry

    NASA Astrophysics Data System (ADS)

    Scalise, Lorenzo; Marchionni, Paolo; Ercoli, Ilaria; Tomasini, Enrico Primo

    2012-06-01

    The paper presents an optical non-contact method for simultaneous measurement of the heart beat and respiration period, based on the assessment of the chest wall movements induced by the pumping action of the heart, and by inspiration/expiration acts of the lungs. The measurement method is applied on 40 patients recovered in a Neonatal Intensive Care Unit (NICU), where the operating conditions are often critical and the contact with the patient's skin needs to be minimized. The method proposed is based on optical recording of the movements of chest wall by means of a laser Doppler vibrometer directly pointed onto the left, frontal part of the thoracic surface. Data measured were compared with reference instrumentation; to reach this goal, the ECG and Laser Doppler Vibrometer (LDV) signals were simultaneously acquired to monitor the heart period (HP), while to measure respiration period (RP) signals from a spirometer and a LDV were collected simultaneously. After LDV signals decomposition, heart and respiration acts were detected and compared in term of beat per minute (bpm). HPs measured by the proposed method showed an uncertainty <6% (respect to ECG), while for RPs data an uncertainty of 3% (respect to spirometer data) was estimated. The proposed method has the intrinsic advantage to be totally without contact and to allow the simultaneous measurement of heart and respiration rate also in critical, clinical environments such as the NICU.

  17. [Vibrations of the human tympanic membrane measured with Laser Doppler Vibrometer].

    PubMed

    Szymański, Marcin; Rusinek, Rafał; Zadrozniak, Marek; Warmiński, Jerzy; Morshed, Kamal

    2009-01-01

    The knowledge of the physiology of the normal ear is important to understand the function of the ear. It is especially crucial in the reconstruction of the destroyed ear to apply the knowledge of the normal ear. We present results of tympanic membrane vibrations measurements using Laser Doppler Vibrometer in human temporal bone specimens. Six temporal bone specimens were harvested within 48 hours of death and stored cooled until preparation. The preparation included mastoidectomy with posterior tympanotomy and partial resection of the facial nerve to visualize the stapes with its footplate. We measured velocity and displacement of each quadrant of the tympanic membrane and the umbo with the laser Vibrometer equipped with velocity and displacement decoders. The sensor head OFV-534 produced and read the reflected laser beam directed at a measured point with a dedicated micromanipulator attached to an operating microscope. A retro-reflective tape was used to enhance the reflection of the laser beam. Vibrations were induced by a acoustic stimulation at the tympanic membrane. The results of the measurements were corrected to a sound pressure in the external ear canal. Laser Doppler Vibrometer system allows an undisturbed measurement of vibrations in the middle ear. Posterior quadrants of the tympanic membrane have greater velocity and displacement than anterior quadrants in lower frequencies up to 2 kHz.

  18. Medical diagnosis of the cardiovascular system on the carotid artery with IR laser Doppler vibrometer

    NASA Astrophysics Data System (ADS)

    Mignanelli, Laura; Rembe, Christian; Kroschel, Kristian; Luik, Armin; Castellini, Paolo; Scalise, Lorenzo

    2014-05-01

    Laser Doppler Vibrometry (LDV) is known to be a possible diagnosis tool for many cardiac applications as the detection and monitoring of some important vital parameters (Heart Rate, Heart Rate Variability, Pulse Wave Velocity) in a non-contact and non-intrusive way. The technique has become known as Optical Vibrocardiography (VCG) i.e. by measuring the vibrations on the carotid artery or on the thorax [1-5]. The aim of the present study is to interpret the vibrational signal acquired from the carotid artery in relation to the electrocardiographic and hemodynamic aspects and to enable the extraction of further medical information relevant for diagnosis purpose. For the investigation an infrared (IR) Laser Doppler Vibrometer has been used. The acquired VCG signals have been processed and compared with the simultaneously acquired electrocardiogram and the color-coded Doppler sonogram. This has enabled a deeper understanding of the signature of the vibrational signal. Furthermore, in this paper, we also discuss the medical value of the VCG signal obtained from the carotid artery.

  19. Torsional vibration measurements on rotating shaft system using laser doppler vibrometer

    NASA Astrophysics Data System (ADS)

    Xiang, Ling; Yang, Shixi; Gan, Chunbiao

    2012-11-01

    In this work, a laser torsional vibrameter was used to measure the torsion vibration of a rotating shaft system under electrical network impact. Based on the principles of laser Doppler velocimetry, the laser torsional vibrometer (LTV) are non-contact measurement of torsional oscillation of rotating shafts, offering significant advantages over conventional techniques. Furthermore, a highly complex shafting system is analyzed by a modified Riccati torsional transfer matrix. The system is modeled as a chain consisting of an elastic spring with concentrated mass points, and the multi-segments lumped mass model is established for this shafting system. By the modified Riccati torsional transfer matrix method, an accumulated calculation is effectively eliminated to obtain the natural frequencies. The electrical network impacts can activize the torsional vibration of shaft system, and the activized torsion vibration frequencies contained the natural frequencies of shaft system. The torsional vibrations of the shaft system were measured under electrical network impacts in laser Doppler torsional vibrometer. By comparisons, the natural frequencies by measurement were consistent with the values by calculation. The results verify the instrument is robust, user friendly and can be calibrated in situ. The laser torsional vibrometer represents a significant step forward in rotating machinery diagnostics.

  20. Surface wave measurements using a single continuously scanning laser Doppler vibrometer: application to elastography.

    PubMed

    Salman, Muhammad; Sabra, Karim G

    2013-03-01

    A continuous scanning laser Doppler vibrometry (CSLDV) obtained sweeping a single laser beam along a periodic scan pattern allows measuring surface vibrations at many points simultaneously by demultiplexing the CSLDV signal. This known method fundamentally differs from conventional scanning laser vibrometry techniques in which the laser beam is kept at a fixed point during each measurement and then moved to a new position prior to the next measurement. This article demonstrates the use of a CSLDV for measuring in a non-contact fashion the velocity of low-frequency surface waves (f < 100 Hz) propagating over soft materials, namely here gel surfaces-mimicking human body soft tissues-and skeletal muscles, to develop an affordable and noninvasive elastography modality. The CSLDV vibration measurements obtained with a single laser beam, linearly scanned over the test surface at 200 Hz over lengths up to 6 cm, were validated using an array of three fixed laser Doppler vibrometers distributed along the same scan line. Furthermore, this CSLDV setup was used to measure the increase in surface wave velocity over the biceps brachii muscle which was directly correlated to the actual stiffening of the biceps occurring while a subject was performing voluntary contractions at an increasing level. PMID:23463997

  1. Laser Doppler visualisation of the fields of three-dimensional velocity vectors with the help of a minimal number of CCD cameras

    SciTech Connect

    Dubnishchev, Yu N

    2010-08-27

    We discuss the possibility of laser Doppler visualisation and measurement of the field of three-dimensional velocity vectors by suppressing the multiparticle scattering influence on the measurement results, when using one CCD camera. The coordinate measuring basis is formed due to switching of the directions and the frequency of spatially combined laser sheets, the frequency being synchronised with the CCD-camera operation. The field of the velocity vectors without the contribution from the multiparticle scattering is produced from the linear combinations of normalised laser sheet images detected with a CCD camera in a frequency-demodulated scattered light. The method can find applications not only in laser diagnostics of gas and condensed media but also in the Doppler spectroscopy of light fields scattered by multiparticle dynamic structures. (laser applications and other topics in quantum electronics)

  2. Quantification of the Blood Platelet Reactivity in the ADP-Induced Model of Non-Lethal Pulmonary Thromboembolism in Mice with the Use of Laser Doppler Flowmetry

    PubMed Central

    Przygodzki, Tomasz; Talar, Marcin; Blazejczyk, Agnieszka; Kalchenko, Vyacheslav; Watala, Cezary

    2016-01-01

    Introduction The paper describes an alternative method for quantification of in vivo ADP-induced thromboembolism. The aim of the studies was to develop a method of quantification which would not require either extravasation or labelling of platelets. Our proposed approach is based on the monitoring of changes of blood flow with the use of laser Doppler flowmetry. Materials and Methods Mice of C57Bl strain were used in the study. ADP was injected to the vena cava and blood flow was monitored with the use of a laser Doppler flowmeter in the mesentery. Measurements in platelet-depleted mice, mice pretreated with cangrelor, an ADP receptor antagonist, and eptifibatide, a blocker of fibrinogen binding to GPIIbIIIa, were conducted as the proof-of-concept in the performed experiments. Intravital microscopy and ex vivo imaging of organs was performed to identify the sites of aggregate formation resulting from ADP injection. Results The injection of ADP resulted in a dose-dependent reduction of the blood flow in the mesentery. These responses were fully attributable to blood platelet aggregation, as shown by the lack of the effect in platelet-depleted mice, and significantly reduced responses in mice pretreated with cangrelor and eptifibatide. No platelet aggregate formation in mesenteric vessels was revealed by intravital microscopy, while ex vivo imaging showed accumulation of fluorescent labelled platelets in the lung. Conclusions Injection of ADP to the venous system results in the formation of platelet aggregates predominantly in the lung. This results in reversible blood flow cessation in peripheral blood vessels. The measurement of this blood flow cessation in the mesentery allows indirect measurement of ADP-induced pulmonary thromboembolism. We suggest that this approach can be useful for in vivo screening for antiplatelet drug candidates. PMID:26751810

  3. Full-field OCT combined with optical tweezer

    NASA Astrophysics Data System (ADS)

    Choi, Woo June; Park, Kwan Seob; Eom, Tae Joong; Oh, Myung-Kyu; Lee, Byeong-Ha

    2012-03-01

    We present an optical tweezer technique assisted full-field optical coherence tomography (FF-OCT) system. The proposed scheme enables ultrahigh-resolution OCT imaging of a floating object optically trapped by single-beam gradient force in medium. The set up consists of a Linnik type of white light interference microscope combined with an optical tweezer system. The optical trap is formed by tightly focusing a 1064 nm Q-switching pulsed laser beam with a microscope objective lens of high numerical aperture (1.0 NA) in sample arm of the OCT interferometer. This co-sharing of probe channel between two of systems enables concurrent actions of trapping and OCT imaging for the sample. OCT imaging of the sample in depth can achieve by positioning the coherence gating with displacement of reference arm in the OCT interferometer. To demonstrate the efficacy of the system, micron-sized dielectric particles and living cells in solution are simultaneously trapped and optically sliced with cellular resolution.

  4. Full-field characterization of mechanical behavior of polyurethane foams.

    SciTech Connect

    Lu, Wei-Yang; Neilsen, Michael K.; Hinnerichs, Terry Dean; Scheffel, Simon; Jin, Huiqing

    2006-02-01

    The foam material of interest in this investigation is a rigid closed-cell polyurethane foam PMDI with a nominal density of 20 pcf (320 kg/m{sup 3}). Three separate types of compression experiments were conducted on foam specimens. The heterogeneous deformation of foam specimens and strain concentration at the foam-steel interface were obtained using the 3-dimensional digital image correlation (3D-DIC) technique. These experiments demonstrated that the 3D-DIC technique is able to obtain accurate and full-field large deformation of foam specimens, including strain concentrations. The experiments also showed the effects of loading configurations on deformation and strain concentration in foam specimens. These DIC results provided experimental data to validate the previously developed viscoplastic foam model (VFM). In the first experiment, cubic foam specimens were compressed uniaxially up to 60%. The full-field surface displacement and strain distributions obtained using the 3D-DIC technique provided detailed information about the inhomogeneous deformation over the area of interest during compression. In the second experiment, compression tests were conducted for cubic foam specimens with a steel cylinder inclusion, which imitate the deformation of foam components in a package under crush conditions. The strain concentration at the interface between the steel cylinder and the foam specimen was studied in detail. In the third experiment, the foam specimens were loaded by a steel cylinder passing through the center of the specimens rather than from its end surface, which created a loading condition of the foam components similar to a package that has been dropped. To study the effects of confinement, the strain concentration and displacement distribution over the defined sections were compared for cases with and without a confinement fixture.

  5. Full-field imprinting of sub-40 nm patterns

    NASA Astrophysics Data System (ADS)

    Yeo, Jeongho; Kim, Hoyeon; Eynon, Ben

    2008-03-01

    Imprint lithography has been included on the ITRS Lithography Roadmap at the 32, 22 and 16 nm nodes. Step and Flash Imprint Lithography (S-FIL (R)) is a unique patterning method that has been designed from the beginning to enable precise overlay to enable multilevel device fabrication. A photocurable low viscosity resist is dispensed dropwise to match the pattern density requirements of the device, thus enabling patterning with a uniform residual layer thickness across a field and across multiple wafers. Further, S-FIL provides sub-50 nm feature resolution without the significant expense of multi-element projection optics or advanced illumination sources. However, since the technology is 1X, it is critical to address the infrastructure associated with the fabrication of imprint masks (templates). For sub-32 nm device manufacturing, one of the major technical challenges remains the fabrication of full-field 1x imprint masks with commercially viable write times. Recent progress in the writing of sub-40 nm patterns using commercial variable shape e-beam tools and non-chemically amplified resists has demonstrated a very promising route to realizing these objectives, and in doing so, has considerably strengthened imprint lithography as a competitive manufacturing technology for the sub-32nm node. Here we report the first imprinting results from sub-40 nm full-field patterns, using Samsung's current flash memory production device design. The fabrication of the imprint mask and the resulting critical dimension control and uniformity are discussed, along with image placement results. The imprinting results are described in terms of CD uniformity, etch results, and overlay.

  6. Advanced materials characterization based on full field deformation measurements

    NASA Astrophysics Data System (ADS)

    Carpentier, A. Paige

    Accurate stress-strain constitutive properties are essential for understanding the complex deformation and failure mechanisms for materials with highly anisotropic mechanical properties. Among such materials, glass-fiber- and carbon-fiber-reinforced polymer--matrix composites play a critical role in advanced structural designs. The large number of different methods and specimen types currently required to generate three-dimensional allowables for structural design slows down the material characterization. Also, some of the material constitutive properties are never measured due to the prohibitive cost of the specimens needed. This work shows that simple short-beam shear (SBS) specimens are well-suited for measurement of multiple constitutive properties for composite materials and that can enable a major shift toward accurate material characterization. The material characterization is based on the digital image correlation (DIC) full-field deformation measurement. The full-field-deformation measurement enables additional flexibility for assessment of stress--strain relations, compared to the conventional strain gages. Complex strain distributions, including strong gradients, can be captured. Such flexibility enables simpler test-specimen design and reduces the number of different specimen types required for assessment of stress--strain constitutive behavior. Two key elements show advantage of using DIC in the SBS tests. First, tensile, compressive, and shear stress--strain relations are measured in a single experiment. Second, a counter-intuitive feasibility of closed-form stress and modulus models, normally applicable to long beams, is demonstrated for short-beam specimens. The modulus and stress--strain data are presented for glass/epoxy and carbon/epoxy material systems. The applicability of the developed method to static, fatigue, and impact load rates is also demonstrated. In a practical method to determine stress-strain constitutive relations, the stress

  7. Laser Doppler vibrometer measurement on spiders in moving-coil loudspeakers

    NASA Astrophysics Data System (ADS)

    Kong, Xiaopeng; Zeng, Xinwu; Tian, Zhangfu

    2014-12-01

    The spider is the dominate stiffness to suspend the cone for a moving-coil loudspeaker unit, and is most commonly a concentrically corrugated fabric disk. A subwoofer closed box is designed to excite the tested spiders pneumatically, and the Laser Doppler Vibrometer (LDV) is used to measure the velocity of the moving spiders. The effective stiffness, loss factor and some viscoelastic behaviors such as level dependent stiffness have been investigated. The results find that, this pneumatic non-contact dynamic technique successfully measured the viscoelastic behaviors of spiders from extremely low frequency 5 Hz to 200 Hz, and the effective stiffness of spiders is dependent on the input voltage level, which is higher level with lower stiffness.

  8. Two-dimensional Laser-Doppler measurements of fluctuations of velocity in an excited jet

    NASA Astrophysics Data System (ADS)

    Meyer, P.; Sava, P. G.

    Two-component laser Doppler anemometry has been used to study velocity fluctuations in excited jets for a Strouhal number of 0.5 and a Reynolds number of 600,000. Streak lines calculated from measurements of the periodic pulsations of the jet are shown to be in good agreement with the results of stroboscopic visualization experiments and analytical calculations. Their evolution in time shows that the flow is nearly stationary in a coordinate system moving with the coherent structure for the case where the coherence is strong. In such a moving system, the trajectories provide information on the motion of fluid particles and, particularly, on the entrainment of fluid by the jet.

  9. Laser Doppler vibrometry measurements of the carotid pulse: biometrics using hidden Markov models

    NASA Astrophysics Data System (ADS)

    Kaplan, Alan D.; O'Sullivan, Joseph A.; Sirevaag, Erik J.; Rohrbaugh, John W.

    2009-05-01

    Small movements of the skin overlying the carotid artery, arising from pressure pulse changes in the carotid during the cardiac cycle, can be detected using the method of Laser Doppler Vibrometry (LDV). Based on the premise that there is a high degree of individuality in cardiovascular function, the pulse-related movements were modeled for biometric use. Short time variations in the signal due to physiological factors are described and these variations are shown to be informative for identity verification and recognition. Hidden Markov models (HMMs) are used to exploit the dependence between the pulse signals over successive cardiac cycles. The resulting biometric classification performance confirms that the LDV signal contains information that is unique to the individual.

  10. Perfusion assessment in rat spinal cord tissue using photoplethysmography and laser Doppler flux measurements

    NASA Astrophysics Data System (ADS)

    Phillips, Justin P.; Cibert-Goton, Vincent; Langford, Richard M.; Shortland, Peter J.

    2013-03-01

    Animal models are widely used to investigate the pathological mechanisms of spinal cord injury (SCI), most commonly in rats. It is well known that compromised blood flow caused by mechanical disruption of the vasculature can produce irreversible damage and cell death in hypoperfused tissue regions and spinal cord tissue is particularly susceptible to such damage. A fiberoptic photoplethysmography (PPG) probe and instrumentation system were used to investigate the practical considerations of making measurements from rat spinal cord and to assess its suitability for use in SCI models. Experiments to assess the regional perfusion of exposed spinal cord in anesthetized adult rats using both PPG and laser Doppler flowmetry (LDF) were performed. It was found that signals could be obtained reliably from all subjects, although considerable intersite and intersubject variability was seen in the PPG signal amplitude compared to LDF. We present results from 30 measurements in five subjects, the two methods are compared, and practical application to SCI animal models is discussed.

  11. Laser Doppler instrumentation for the measurement of retinal blood flow: theory and practice.

    PubMed

    Feke, G T

    2006-01-01

    The theory underlying the development of laser Doppler instrumentation for the measurement of retinal blood flow is framed in terms of (a) the enunciation of the Doppler principle; (b) the invention of the laser; and (c) the invention of the technique known as optical mixing spectroscopy. The features of the instrumentation, beginning with the first prototype in 1972 and culminating with the introduction of the Canon Laser Blood Flowmeter in 1998 are presented in detail. Results from seven separate studies reporting on the reproducibility of retinal blood flow measurements using the Canon instrument, as well as a review of 12 separate presentations made at the 2004 annual meeting of the Association for Research in Vision and Ophthalmology (ARVO) using the Canon instrument in studies involving retinal circulatory physiology and associated clinical research are also presented. PMID:17265797

  12. The Use of a Laser Doppler Velocimeter in a Standard Flammability Tube

    NASA Technical Reports Server (NTRS)

    Strehlow, R. A.; Flynn, E. M.

    1985-01-01

    The use of the Laser Doppler Velocimeter, (LDV), to measure the flow associated with the passage of a flame through a standard flammability limit tube (SFLT) was studied. Four major results are presented: (1) it is shown that by using standard ray tracing calculations, the displacement of the LDV volume and the fringe rotation within the experimental error of measurement can be predicted; (2) the flow velocity vector field associated with passage of an upward propagating flame in an SFLT is determined; (3) it is determined that the use of a light interruption technique to track particles is not feasible; and (4) it is shown that a 25 mW laser is adequate for LDV measurements in the Shuttle or Spacelab.

  13. Measurement of blood velocity using laser Doppler method for the designing module

    NASA Astrophysics Data System (ADS)

    Chen, Guo-Liang; Lee, Jen-Ai; Lu, Tung-Wu; Chen, Zhao-Cheng; Chen, Chien-Ming

    2005-04-01

    We built the Dual Beam Mode of the LDA (Laser Doppler Anemometry) frame, set the photodetector at the same side with light source which collect the scattering light of blood cell. It's proper to reduce LDA optical path and convenient for our designing module. The concentration of chicken blood in this study is about 1% and we measured the relations actually between flood velocity and the angle of beams cross on particles, temperature, and the diameter of aqueduct. We found better results while the cross angle was less than 38.8 degree, diameter of aqueduct was 6 mm, and temperature of blood was set to 36 . These parameters can also provide important basis for the LDA module kit that we are designing.

  14. Development of a laser Doppler system for the detection and monitoring of atmospheric disturbances

    NASA Technical Reports Server (NTRS)

    Jeffreys, H. B.; Bilbro, J. W.

    1975-01-01

    A Scanning Laser Doppler Velocimeter System (SLDVS) capable of detecting and monitoring atmospheric disturbances, including wake vortices of landing aircraft and vertical wind profiles in the atmosphere was developed. The SLDVS is a focused, continuous wave, CO2 system that determines the line-of-sight velocities of particles in the focal volume by measuring the Doppler shift created by these particles. At present, the SLDVS is designed to have a range coverage of approximately 2000 ft with a vertical angle coverage of approximately 60 deg. It is also designed to detect Doppler velocities of up to 200 ft/sec with a velocity resolution of approximately 1.8 ft/sec. A complete velocity spectrum is provided by the SLDVS at each point in space at which it is focused. The overall operation and performance of the system and the description of its individual components and data handling capabilities were given.

  15. Spectral analysis of laser Doppler signals in real time using digital processing.

    PubMed

    Dougherty, G

    1994-01-01

    A versatile spectrum analyser was developed to generate and display laser Doppler shift signals, and derived parameters, continuously in real time using a digital signal processing chip. A major attraction of the system is that it is entirely programmable, so that both the algorithms and the attributes of the system, such as window function and frame overlap, can be easily altered. It was used to investigate the relative merits of a variety of algorithms using a blood-flow phantom. An index based on the first moment of the Doppler power spectrum was found to be the most reliable flow indicator, with linearity extending towards a velocity of 5 mm s-1 for a blood haematocrit of 5%. The system is not limited to analysis based on the fast Fourier transform (FFT), and is suitable for non-linear techniques such as maximum entropy spectral estimation (MESE). PMID:8162263

  16. Combined medical diagnostic system with separated laser-Doppler and reflectance oximeter channels

    NASA Astrophysics Data System (ADS)

    Amzina, M. V.; Micheev, A. A.; Rogatkin, D. A.; Sidorov, V. V.

    2006-08-01

    On the basis of studying of opportunities of Reflectance Tissues Oximetry (RTO) as well as on the basis of RTO and Laser Doppler Flowmetry (LDF) comparative data, received in Moscow Regional Research and Clinical Institute "MONIKI" while patients with the peripheral blood microcirculation disorders were under examination, it was offered to unite the RTO and LDF techniques in a single diagnostic system. The new two-channel diagnostic system will contain the first LDF channel to measure the blood microcirculation parameters and the second RTO channel to register an average peripheral blood oxygenation. In the report the features of the new system design and a number of experimental data on correlation of RTO and LDF results are considered. The prospects of amalgamation of these two different techniques in a single diagnostic device are shown as well.

  17. A study on a coincidence phenomenon in building partitions using Laser Doppler Vibrometer

    NASA Astrophysics Data System (ADS)

    Bolejko, Romuald

    2012-06-01

    In the paper results of vibrations measurements of the partitions with finished dimensions done in anechoic environment using scanning laser Doppler vibrometer are presented. It has allowed presentation a complex pattern of vibration and flow of vibration energy caused by bending waves in a partition at coincidence frequencies. A study was done for homogenous aluminum plates, aluminum plate with damping coatings and double-leaf partition composed by aluminum plates with different thickness. It was demonstrated that magnitude and pattern of vibration of each leafs of the double partition is correlated in specific way. The influence of structural modifications (stiffeners) and damping coating of a partition on its vibration and sound insulation was discussed. It was shown that such partition modification could decrease an effect of the coincidence on sound transmission through a partition.

  18. Pseudo-backscatter laser Doppler velocimeter employing antiparallel-reflector in the forward direction

    NASA Technical Reports Server (NTRS)

    Gunter, W. D., Jr. (Inventor)

    1977-01-01

    A laser Doppler velocimeter for measuring the velocity of a flowing fluid was discussed. It comprises laser means for providing first and second beams of collimated coherent monochromatic electromagnetic radiation which are focused to intersect at a predetermined location in a flowing fluid. The movement of the particles of the fluid serve to scatter radiation in substantially all directions. The scattered radiation is shifted in frequency from that of the first beam by an amount corresponding to the velocity of the fluid at the predetermined location. A corner cube is disposed generally forward of the predetermined location, the corner cube responding to a portion of the radiation scattered in the forward direction and being operative to reflect the portion in a direction substantially antiparallel to the forward direction.

  19. Droplet sizes and velocities in vaporizing sprays. [using laser Doppler anemometry

    NASA Technical Reports Server (NTRS)

    Yule, A. J.; Ereaut, P. R.; Ungut, A.

    1983-01-01

    A pulse height laser Doppler anemometer particle sizing technique has been refined to permit simultaneous particle size and velocity measurements in sprays. The improvements include (1) the use of a specially tailored 'top hat' light distribution, to provide unambiguous particle diameter-signal amplitude relations, (2) the use of back scattered light collection, and (3) the utilization of Mie theory to compute the relations between signal amplitude and particle diameter, in the backscatter mode. Twin-fluid atomized kerosene sprays have been investigated using the new technique. In these sprays distributions have been mapped of mean droplet diameters, droplet size distributions, and the local correlations between droplet diameters and velocities. The data show the variation of spray structure with atomizer input parameters, the preferential vaporization of smaller droplets, and the differing trajectories of the large and small droplets.

  20. A technique to measure the size of particles in laser Doppler velocimetry applications

    NASA Technical Reports Server (NTRS)

    Hess, C. F.

    1985-01-01

    A method to measure the size of particles in Laser Doppler Velocimeter (LDV) applications is discussed. Since in LDV the velocity of the flow is assocated with the velocity of particles to establish how well they follow the flow, in the present method the interferometric probe volume is surrounded by a larger beam of different polarization or wavelength. The particle size is then measured from the absolute intensity scattered from the large beam by particles crossing the fringes. Experiments using polystrene particles between 1.1 and 3.3 microns and larger glass beads are reported. It is shown that the method has an excellent size resolution and its accuracy is better than 10% for the particle size studied.

  1. Laser Doppler velocimetry for continuous flow solar-pumped iodine laser system

    NASA Technical Reports Server (NTRS)

    Tabibi, Bagher M.; Lee, Ja H.

    1991-01-01

    A laser Doppler velocimetry (LDV) system was employed to measure the flow velocity profile of iodide vapor inside laser tubes of 36 mm ID and 20 mm ID. The LDV, which was operated in the forward scatter mode used a low power (15 mW) He-Ne laser beam. Velocity ranges from 1 m/s was measured to within one percent accuracy. The flow velocity profile across the laser tube was measured and the intensity of turbulence was determined. The flow of iodide inside the laser tube demonstrated a mixture of both turbulence and laminar flow. The flowmeter used for the laser system previously was calibrated with the LDV and found to be in good agreement.

  2. Effect of timolol on sub-foveal choroidal blood flow using laser Doppler flowmetry

    NASA Astrophysics Data System (ADS)

    Palanisamy, Nithiyanantham; Rovati, Luigi; Cellini, Mauro; Gizzi, Corrado; Strobbe, Ernesto; Campos, Emilio; Riva, Charles E.

    2011-03-01

    Laser Doppler flowmetry (LDF) is a technique used to measure relative average velocity, number and flux (number times velocity) of red blood cells in vessels or capillaries. In this study, the effect of topical timolol on the choroidal circulation was investigated in 12 healthy subjects. Maximum velocity of red blood cells and volumetric blood flow rate in sub-foveal choroids are determined in each eye just before instillation of drops and then every 30 min upto 2 hours. Average intraocular pressure (IOP) decreased significantly in the timolol-treated eyes compared to that of placebo-treated eyes. Nevertheless no significant differences in choroidal blood hemodynamic between timolol and placebo-treated eyes were observed.

  3. Laser Doppler velocimeter measurement in the tip region of a compressor rotor

    NASA Technical Reports Server (NTRS)

    Murthy, K. N. S.; Lakshminarayana, B.

    1984-01-01

    The axial and tangential velocity components near the tip region of a compressor rotor were measured by a laser Doppler velocimeter. The measurements were taken at 25 radial locations in the outer twenty percent of the blade span and at 10 axial locations upstream, inside and at the exit of the rotor. The results are interpreted to derive the behavior of the leakage flow, annulus wall boundary layer growth, inviscid effects and the rotor wake decay characteristics in the tip region. The inviscid and annulus wall boundary layer effects dominate up to quarter chord, beyond which the leakage phenomena has a major influence in altering the flow characteristics in the outer ten percent of the blade span. The annulus wall boundary layer undergoes drastic change through the passage. The velocity field measured near the leading edge reveals the effects of rapid acceleration near the suction surface and the stagnation point on the pressure surface.

  4. Optical measurement of the axial eye length by laser Doppler interferometry.

    PubMed

    Hitzenberger, C K

    1991-03-01

    A new technique has been developed to determine the axial length of the human eye in vivo. Based on laser interferometry in conjunction with the Doppler technique, it uses partially coherent light. This new technique complies with laser safety regulations. High accuracy is achieved, the optical length (OL) can be determined within +/- 30 microns, and the reproducibility of the geometric eye length is greater than +/- 25 microns. Possible errors are discussed. First comparisons with the ultrasound technique yield good agreement for emmetropic subjects and for subjects with a myopia of up to 10 diopters. The advantages of the laser doppler interferometry (LDI) technique are high accuracy, high transversal resolution, and more comfort for the patient (it is a noncontact method; no anesthesia is needed). Possible future applications of LDI, like measurements of fundus profiles and of retinal thickness, are mentioned.

  5. Underwater Acoustic Wavefront Visualization by Scanning Laser Doppler Vibrometer for the Characterization of Focused Ultrasonic Transducers

    PubMed Central

    Longo, Roberto; Vanlanduit, Steve; Arroud, Galid; Guillaume, Patrick

    2015-01-01

    The analysis of acoustic wave fields is important for a large number of engineering designs, communication and health-related reasons. The visualization of wavefronts gives valuable information about the type of transducers and excitation signals more suitable for the test itself. This article is dedicated to the development of a fast procedure for acoustic fields visualization in underwater conditions, by means of laser Doppler vibrometer measurements. The ultrasonic probe is a focused transducer excited by a chirp signal. The scope of this work is to evaluate experimentally the properties of the sound beam in order to get reliable information about the transducer itself to be used in many kinds of engineering tests and transducer design. PMID:26287197

  6. Conformal scanning laser Doppler vibrometer measurement of tenor steelpan response to impulse excitation.

    PubMed

    Ryan, Teresa; O'Malley, Patrick; Glean, Aldo; Vignola, Joseph; Judge, John

    2012-11-01

    A conformal scanning laser Doppler vibrometer system is used in conjunction with a mechanical pannist to measure the surface normal vibration of the entire playing surface of a C-lead tenor steelpan. The mechanical pannist is a device designed to deliver controlled, repeatable strikes that mimic a mallet during authentic use. A description of the measurement system is followed by select examples of behavior common to the results from three different excitation notes. A summary of observed response shapes and associated frequencies demonstrates the concerted placement of note overtones by the craftsmen who manufacture and tune the instruments. The measurements provide a rich mechanical snapshot of the complex motion that generates the distinctive sound of a steelpan.

  7. Numerical solutions and laser-Doppler measurements of spin-up

    NASA Technical Reports Server (NTRS)

    Warn-Varnas, A.; Piacsek, S.; Fowlis, W. W.; Lee, S. M.

    1978-01-01

    The spin-up flow in a cylinder of homogeneous fluid has been examined both experimentally and numerically. A series of laser-Doppler measurements was made of the zonal flow over a range of Ekman numbers and Rossby numbers at various locations in the interior of the flow. These measurements exceed previous ones in accuracy. The weak inertial modes excited by the impulsive start are detectable. The numerical simulations used the primitive equations in axisymmetric form and employed finite-difference techniques on both constant and variable grids. The number of grid points necessary to resolve the Ekman layers was determined. A thorough comparison of the simulations and the experimental measurements is made which includes the details of the amplitude and frequency of the inertial modes. Agreement to within the experimental tolerance is achieved. Analytical results for conditions identical to those in the experiments are not available but some similar linear and nonlinear theories are also compared with the experiments.

  8. Quantitative measurement of blood flow dynamics in chorioallantoic membrane of chicken embryo using laser Doppler anemometry

    NASA Astrophysics Data System (ADS)

    Borozdova, M. A.; Stiukhina, E. S.; Sdobnov, A. A.; Fedosov, I. V.; Postnov, D. E.; Tuchin, V. V.

    2016-04-01

    We report the results on in ovo application of developed Laser Doppler Anemometer (LDA) device. The chorioallantoic membrane (CAM) of 9-13 days chicken embryos was used as a biological model that allows an easy access to both arterial and venous vessels of different size. The key point of our study was to find out how the periodic and aperiodic pulsations of blood flow (which are inevitable in living organism) will affect the LDA functions and measuring capability. Specifically, we (i) developed the technique to extract and refine the pulse rhythm from the signal received from a vessel, and (ii) analyzed the changes in power spectra of LDA signal that are caused by heart beating and considerably complicate the reliable measurement of Doppler shift. Our main conclusion is that the algorithm of LDA data processing need to be improved, and this possibly can be done by counting the information on current phase of cardiac cycle.

  9. Velocity distribution measurements in a fishway like open channel by Laser Doppler Anemometry (LDA)

    NASA Astrophysics Data System (ADS)

    Sayeed-Bin-Asad, S. M.; Lundström, T. S.; Andersson, A. G.; Hellström, J. G. I.

    2016-03-01

    Experiments in an open channel flume with placing a vertical half cylinder barrier have been performed in order to investigate how the upstream velocity profiles are affected by a barrier. An experimental technique using Laser Doppler Velocimetry (LDV) was adopted to measure these velocity distributions in the channel for four different discharge rates. Velocity profiles were measured very close to wall and at 25, 50 and 100 mm upstream of the cylinder wall. For comparing these profiles with well-known logarithmic velocity profiles, velocity profiles were also measured in smooth open channel flow for all same four discharge rates. The results indicate that regaining the logarithmic velocity profiles upstream of the half cylindrical barrier occurs at 100 mm upstream of the cylinder wall.

  10. Eye-tracking laser Doppler velocimeter stabilized in two dimensions: principle, design, and construction.

    PubMed

    Mendel, M J; Toi, V V; Riva, C E; Petrig, B L

    1993-07-01

    We developed an eye-tracking laser Doppler velocimeter to minimize eye-movement artifacts in the study of ocular hemodynamics in humans. The instrument compensates for both horizontal and vertical eye motions by using galvanometer mirrors controlled by a dual-Purkinje eye tracker. The performance of the instrument is demonstrated in a preliminary study of retinal arterial blood velocity in a normal subject. The subject's fixation point was adjusted manually to oscillate through a 2.3-deg span at 0.3 Hz. In spite of this motion the pulsatile velocity waveform of the heart cycle could be continuously recorded. Without eye tracking the velocity waveform was lost after the initiation of movement. PMID:8350156

  11. Barriers to the management of Diabetes Mellitus - is there a future role for Laser Doppler Flowmetry?

    PubMed

    Au, Minnie; Rattigan, Stephen

    2012-01-01

    Diabetes Mellitus (DM) is a chronic disease that carries a significant disease burden in Australia and worldwide. The aim of this paper is to identify current barriers in the management of diabetes, ascertain whether there is a benefit from early detection and determine whether LDF has the potential to reduce the disease burden of DM by reviewing the literature relating to its current uses and development. In this literature review search terms included; laser Doppler flowmetry, diabetes mellitus, barriers to management, uses, future, applications, vasomotion, subcutaneous, cost. Databases used included Google Scholar, Scopus, Science Direct and Medline. Publications from the Australian government and textbooks were also utilised. Articles reviewed had access to the full text and were in English. PMID:23382766

  12. A novel laser Doppler velocimeter and its integrated navigation system with strapdown inertial navigation

    NASA Astrophysics Data System (ADS)

    Zhou, Jian; Nie, Xiaoming; Lin, Jun

    2014-12-01

    In order to suppress the error accumulation effect of inertial navigation system (INS), an idea of building an integrated navigation system using a laser Doppler velocimeter (LDV) together with strapdown inertial navigation (SIN) is proposed. The basic principle of LDV is expounded while a novel LDV with advanced optical structure is designed based on the split and reuse technique, and the process of dead reckoning using an integrated system which consists of LDV and SIN is discussed detailedly. The results of theory and experiment show that: the split and reuse type LDV has great advantages of high accuracy and signal-to-noise ratio, which has greatly enhanced the position accuracy of the navigation system. The position error has been decreased from 1166 m in 2 h with pure SIN to 20 m in 2 h with the integrated system.

  13. An experimental study of a three-dimensional thrust augmenting ejector using laser Doppler velocimetry

    NASA Technical Reports Server (NTRS)

    Storms, Bruce Lowell

    1989-01-01

    Flow field measurements were obtained in a three-dimensional thrust augmenting ejector using laser Doppler velocimetry and hot wire anemometry. The primary nozzle, segmented into twelve slots of aspect ratio 3.0, was tested at a pressure ratio of 1.15. Results are presented on the mean velocity, turbulence intensity, and Reynolds stress progressions in the mixing chamber of the constant area ejector. The segmented nozzle was found to produce streamwise vortices that may increase the mixing efficiency of the ejector flow field. Compared to free jet results, the jet development is reduced by the presence of the ejector walls. The resulting thrust augmentation ratio of this ejector was also calculated to be 1.34.

  14. Development of a new laser Doppler velocimeter for the Ames High Reynolds Channel No. 2

    NASA Technical Reports Server (NTRS)

    Seegmiller, H. L.; Bader, J. B.; Cooney, J. P.; Deyoung, A.; Donaldson, R. W., Jr.; Gunter, W. D., Jr.; Harrison, D. R.

    1985-01-01

    A new two-channel laser Doppler velocimeter developed for the Ames High Reynolds Channel No. 2 is described. Design features required for the satisfactory operation of the optical system in the channel environment are discussed. Fiber optics are used to transmit the megahertz Doppler signal to the photodetectors located outside the channel pressure vessel, and provision is made to isolate the optical system from pressure and thermal strain effects. Computer-controlled scanning mirrors are used to position the laser beams in the channel flow. Techniques used to seed the flow with 0.5-micron-diam polystyrene spheres avoiding deposition on the test-section windows and porous boundary-layer removal panels are described. Preliminary results are presented with a discussion of several of the factors affecting accuracy.

  15. A microcomputer based frequency-domain processor for laser Doppler anemometry

    NASA Technical Reports Server (NTRS)

    Horne, W. Clifton; Adair, Desmond

    1988-01-01

    A prototype multi-channel laser Doppler anemometry (LDA) processor was assembled using a wideband transient recorder and a microcomputer with an array processor for fast Fourier transform (FFT) computations. The prototype instrument was used to acquire, process, and record signals from a three-component wind tunnel LDA system subject to various conditions of noise and flow turbulence. The recorded data was used to evaluate the effectiveness of burst acceptance criteria, processing algorithms, and selection of processing parameters such as record length. The recorded signals were also used to obtain comparative estimates of signal-to-noise ratio between time-domain and frequency-domain signal detection schemes. These comparisons show that the FFT processing scheme allows accurate processing of signals for which the signal-to-noise ratio is 10 to 15 dB less than is practical using counter processors.

  16. A 3-component laser-Doppler velocimeter data acquisition and reduction system

    NASA Technical Reports Server (NTRS)

    Rodman, L. C.; Bell, J. H.; Mehta, R. D.

    1986-01-01

    This report describes a laser Doppler velocimeter capable of measuring all three components of velocity simultaneously in low-speed flows. All the mean velocities, Reynolds stresses, and higher-order products can then be evaluated. The approach followed is to split one of the colors used in a 2-D system, thus creating a third set of beams which is then focused in the flow from an off-axis direction. The third velocity component is computed from the known geometry of the system. In this report, the laser optical hardware and the data acquisition electronics are described in detail. In addition, full operating procedures and listings of the software (written in BASIC and assembly languages) are also included. Some typical measurements obtained with this system in a vortex/mixing layer interaction are presented and compared directly to those obtained with a cross-wire system.

  17. Laser Doppler velocimetry based on the optoacoustic effect in a RF-excited CO2 laser.

    PubMed

    Lee, Teaghee; Choi, Jong Woon; Kim, Yong Pyung

    2012-09-01

    We present a compact optoacoustic laser Doppler velocimetry method that utilizes the self-mixing effect in a RF-excited CO(2) laser. A portion of a Doppler-shifted laser beam, produced by irradiating a single wavelength laser beam on a moving object, is mixed with an originally existing laser beam inside a laser cavity. The fine change of pressure in the laser cavity modulated by the Doppler-shifted frequency is detected by a condenser microphone in the laser tube. In our studies, the frequency of the Doppler signal due to the optoacoustic effect was detected as high as 50 kHz. Our measurements also confirmed that the signal varied linearly with the velocity of the external scatterer (the moving object) and the cosine of the angle between the laser beam and the velocity vector of the object.

  18. Feasibility of Laser Doppler Vibrometry as potential diagnostic tool for patients with abdominal aortic aneurysms.

    PubMed

    Schuurman, T; Rixen, D J; Swenne, C A; Hinnen, J-W

    2013-04-01

    The application of laser measurements in medical applications makes it possible to measure even very small vibrations without contacting the skin surface. In the present work we investigate the use of a scanning vibrometer to measure the mechanical wave of the abdominal wall caused by the heart beat and blood pressure pulse. A Laser Doppler Vibrometer, triggered by cardiac signals, is used to scan points on a grid positioned on the abdomen of human subjects. The proposed procedure is intended for detecting anomalies in the abdominal cavity such as aortic aneurysms. Here, we outline the technical setup used in our preliminary in vivo experiments and present some preliminary results. This feasibility study shows that the proposed measurement procedure allows for measuring the skin motion, that the skin motion measured is related to the heart activity, and that there are indication that the presence of an abdominal aortic aneurysm significantly modifies the relation between blood pressure pulsations and skin motion on the abdomen.

  19. IN-PLANE MODAL TESTING OF A FREE ISOTROPIC PLATE USING LASER DOPPLER VIBROMETER MEASUREMENTS

    SciTech Connect

    Batista, F. B.; Fabro, A. T.; Coser, L. F.; Arruda, J. R. F.; Albuquerque, E. L.

    2010-05-28

    In this work an experimental procedure is proposed to obtain the lowest free in-plane vibration modes of an aluminum plate. Responses are measured along two longitudinal directions on the plate surface at selected points by an out-of-plane laser Doppler vibrometer set up to measure in-plane vibrations. Excitation is made at one specific point of the plate edge using a light impact hammer. The plate is supported by silicone spheres to simulate the free edge boundary conditions and ensure a stable stationary position in order to keep the laser focus distance. Numerical finite element simulations are carried out to compute the in-plane modes and frequencies in order to compare them with the corresponding experimental results. The identified experimental modes agree very well with the numerical predictions. The smooth in-plane modes can be used to identify the plate material constitutive model parameters using existing methods proposed elsewhere by the authors.

  20. On-chip laser Doppler vibrometer for arterial pulse wave velocity measurement.

    PubMed

    Li, Yanlu; Segers, Patrick; Dirckx, Joris; Baets, Roel

    2013-07-01

    Pulse wave velocity (PWV) is an important marker for cardiovascular risk. The Laser Doppler vibrometry has been suggested as a potential technique to measure the local carotid PWV by measuring the transit time of the pulse wave between two locations along the common carotid artery (CCA) from skin surface vibrations. However, the present LDV setups are still bulky and difficult to handle. We present in this paper a more compact LDV system integrated on a CMOS-compatible silicon-on-insulator substrate. In this system, a chip with two homodyne LDVs is utilized to simultaneously measure the pulse wave at two different locations along the CCA. Measurement results show that the dual-LDV chip can successfully conduct the PWV measurement.

  1. Underwater Acoustic Wavefront Visualization by Scanning Laser Doppler Vibrometer for the Characterization of Focused Ultrasonic Transducers.

    PubMed

    Longo, Roberto; Vanlanduit, Steve; Arroud, Galid; Guillaume, Patrick

    2015-08-13

    The analysis of acoustic wave fields is important for a large number of engineering designs, communication and health-related reasons. The visualization of wavefronts gives valuable information about the type of transducers and excitation signals more suitable for the test itself. This article is dedicated to the development of a fast procedure for acoustic fields visualization in underwater conditions, by means of laser Doppler vibrometer measurements. The ultrasonic probe is a focused transducer excited by a chirp signal. The scope of this work is to evaluate experimentally the properties of the sound beam in order to get reliable information about the transducer itself to be used in many kinds of engineering tests and transducer design.

  2. Hidden state dynamics in laser Doppler vibrometery measurements of the carotid pulse under resting conditions.

    PubMed

    Kaplan, Alan D; O'Sullivan, Joseph A; Sirevaag, Erik J; Kristjansson, Sean D; Lai, Po-Hsiang; Rohrbaugh, John W

    2010-01-01

    A laser Doppler vibrometer (LDV) is used to sense movements of the skin overlying the carotid artery. Fluctuations in carotid artery diameter due to variations in the underlying blood pressure are sensed at the surface of the skin. Portions of the LDV signal corresponding to single heartbeats, called the LDV pulses, are extracted. This paper introduces the use of hidden Markov models (HMMs) to model the dynamics of the LDV pulse from beat to beat based on pulse morphology, which under resting conditions are primarily due to breathing effects. LDV pulses are classified according to state, by computing the optimal state path through the data using trained HMMs. HMM state dynamics are compared to simultaneous recordings of strain gauges placed on the abdomen. The work presented here provides a robust statistical approach to modeling the dependence of the LDV pulse on latent states.

  3. Clinical utility of laser-Doppler vibrometer measurements in live normal and pathologic human ears.

    PubMed

    Rosowski, John J; Nakajima, Hideko H; Merchant, Saumil N

    2008-01-01

    The laser-Doppler vibrometer (LDV) is a research tool that can be used to quickly measure the sound-induced velocity of the tympanic membrane near the umbo (the inferior tip of the malleus) in live human subjects and patients. In this manuscript we demonstrate the LDV to be a sensitive and selective tool for the diagnosis and differentiation of various ossicular disorders in patients with intact tympanic membranes and aerated middle ears. Patients with partial or total ossicular interruption or malleus fixation are readily separated from normal-hearing subjects with the LDV. The combination of LDV measurements and air-bone gap can distinguish patients with fixed stapes from those with normal ears. LDV measurements can also help differentiate air-bone gaps produced by ossicular pathologies from those associated with pathologies of inner-ear sound conduction such as a superior semicircular canal dehiscence.

  4. Composite Characterization Using Laser Doppler Vibrometry and Multi-Frequency Wavenumber Analysis

    NASA Technical Reports Server (NTRS)

    Juarez, Peter; Leckey, Cara

    2015-01-01

    NASA has recognized the need for better characterization of composite materials to support advances in aeronautics and the next generation of space exploration vehicles. An area of related research is the evaluation of impact induced delaminations. Presented is a non-contact method of measuring the ply depth of impact delamination damage in a composite through use of a Scanning Laser Doppler Vibrometer (SLDV), multi-frequency wavenumber analysis, and a wavenumber-ply correlation algorithm. A single acquisition of a chirp excited lamb wavefield in an impacted composite is post-processed into a numerous single frequency excitation wavefields through a deconvolution process. A spatially windowed wavenumber analysis then extracts local wavenumbers from the wavefield, which are then correlated to theoretical dispersion curves for ply depth determination. SLDV based methods to characterize as-manufactured composite variation using wavefield analysis will also be discussed.

  5. An endoscopic laser Doppler flowmetry of a gastroduodenal mucosa at bleeding ulcer

    NASA Astrophysics Data System (ADS)

    Shapkin, U. G.; Kapralov, C. V.; Gogolev, A. A.; Lychagov, V. V.; Tuchin, V. V.

    2006-08-01

    One of the important problems of a bleeding gastroduodenal ulcer surgery is a prognosis of the recurrent hemorrhage and appraisal of endoscopic hemostasis quality. Endoscopic Laser Doppler Flowmetry of a mucous coat of stomach and a duodenum was made on 34 patients for the purpose of investigation of features of microcirculation. Analogous researches are made on 30 patients with a peptic ulcer and on 28 practically healthy people. Analysis of LDF-grams has shown certain differences in regional microcirculations in stomach and duodenal at normal and at a pathology. Increase of regional perfusion in periulcerose zone with its pathology disbalance can serve as a criterion for activities of an alteration processes in gastroduodenal ulcer defining the risk of possible hemorrhage.

  6. Endoscopic laser Doppler flowmetry in the experiment and in the bleeding gastric and duodenal ulcer clinic

    NASA Astrophysics Data System (ADS)

    Kapralov, S. V.; Shapkin, Y. G.; Lychagov, V. V.; Tuchin, V. V.

    2007-05-01

    One of the most complex problems of emergency surgery is the choice of surgical tactics to deal with bleeding peptic ulcer. Endoscopic hemostasis is prescribed to patients with continuing bleedings and prerelapse syndrome. But till nowdays the objective verification of the prerelapse condition had not been worked out. What is more there are no objective criteria to judge the effectiveness of the carried endohemostasis. The aim of the study was to work out a new objective diagnostic method of pre-recurrence syndrome that can be able to make prognosis for possible gastroduodenal ulcer bleeding recurrence more precise. Laser Doppler flowmetry was the method of studies the regional perfusion. The device used in this work was made at the Optics and Biophysics Department of Saratov State University.

  7. Laser Doppler anemometry measurements in the near-wake of an isolated Formula One wheel

    NASA Astrophysics Data System (ADS)

    Saddington, A. J.; Knowles, R. D.; Knowles, K.

    2007-05-01

    An experimental investigation was conducted to identify the main structures in the near wake of an isolated Formula One wheel rotating in ground contact. A 50 percent-scale isolated wheel assembly, geometrically similar to the configuration mounted on a Formula One racing car, was tested in a closed-return three-quarter open-jet wind tunnel. The test Reynolds number, based on wheel diameter was 6.8 × 105. Using laser doppler anemometry, three velocity components were measured with a total of 1966 data points across four planes and within one diameter downstream of the wheel axis. Based on analysis of these data, the main characteristics of the near-wake of an isolated wheel rotating in ground contact are presented. A revised model of the trailing vortex system induced in the wake of such a wheel is proposed, which clarifies the contradictory ones published in the literature to date.

  8. Measurement of the Resonant Characteristics of a Single Bubble Vibration by Using a Laser Doppler Vibrometer

    NASA Astrophysics Data System (ADS)

    Yoshikawa, Taisuke; Kotera, Hironori; Yoshida, Kenji; Koyama, Daisuke; Nakamura, Kentaro; Watanabe, Yoshiaki

    2011-07-01

    We constructed the experimental system with a laser Doppler vibrometer (LDV) for measuring the vibration of a single microbubble. It was demonstrated that the system enabled the capture of the vibration with an amplitude of nanometer order. We attempted to experimentally measure the resonant characteristics of a bubble attached to a wall by using the system. As a result, we succeeded in measuring the characteristics and evaluating the Q factor and the resonant radius at a driving frequency of 27.8 kHz, although these values are different from those predicted on the basis of the theory for a single free bubble. The LDV measurement system is expected to an effective tool for evaluating bubble vibrations with very small displacement amplitudes, such as the vibration of a microcapsule.

  9. Laser Doppler vibrometry for assessment of arteriosclerosis: A first step towards validation

    NASA Astrophysics Data System (ADS)

    Campo, Adriaan; Dirckx, Joris

    2014-05-01

    It has been shown that in cardiovascular risk management, stiffness of large arteries has a very good predictive value for cardiovascular disease and mortality. This parameter can be estimated from the pulse wave velocity (PWV) measured between the common carotid artery (CCA) in the neck and femoral artery (FA) in the groin. However PWV can also be measured locally in the CCA, using non-invasive methods such as ultrasound (US) or laser Doppler vibrometry (LDV). Potential of the latter approach was already explored in previous research, and in this work a first step towards clinical validation is made. 50 hypertension II/III patients aged between 30 and 65 participate in the study. Patients were asked to remain sober for 4 hours prior to the measurements. The trajectory of the CCA in the neck was determined by a trained clinician guided by an US probe. 3 laser Doppler vibrometer (LDV) systems were aimed along the CCA. PWV was then calculated from the distance between beams and the time-shift between waveforms. Immediately after LDV measurements, PWV was measured with US. Additionally, carotid-femoral PWV was measured. As a validation, PWV results of the different techniques were compared with each other, and with medical background of the test subjects. Since data acquisition is still ongoing, data from only 20 patients will be discussed. No trends between measurement methods for PWV are apparent. However, a positive trend was detected between PWV as measured with LDV and blood pressure. More data, including additional experiments will be needed to verify this observation.

  10. Laser Doppler vibrometry for assessment of arteriosclerosis: A first step towards validation

    SciTech Connect

    Campo, Adriaan; Dirckx, Joris

    2014-05-27

    It has been shown that in cardiovascular risk management, stiffness of large arteries has a very good predictive value for cardiovascular disease and mortality. This parameter can be estimated from the pulse wave velocity (PWV) measured between the common carotid artery (CCA) in the neck and femoral artery (FA) in the groin. However PWV can also be measured locally in the CCA, using non-invasive methods such as ultrasound (US) or laser Doppler vibrometry (LDV). Potential of the latter approach was already explored in previous research, and in this work a first step towards clinical validation is made. 50 hypertension II/III patients aged between 30 and 65 participate in the study. Patients were asked to remain sober for 4 hours prior to the measurements. The trajectory of the CCA in the neck was determined by a trained clinician guided by an US probe. 3 laser Doppler vibrometer (LDV) systems were aimed along the CCA. PWV was then calculated from the distance between beams and the time-shift between waveforms. Immediately after LDV measurements, PWV was measured with US. Additionally, carotid-femoral PWV was measured. As a validation, PWV results of the different techniques were compared with each other, and with medical background of the test subjects. Since data acquisition is still ongoing, data from only 20 patients will be discussed. No trends between measurement methods for PWV are apparent. However, a positive trend was detected between PWV as measured with LDV and blood pressure. More data, including additional experiments will be needed to verify this observation.

  11. The sources of laser Doppler blood-flow signals recorded from human teeth.

    PubMed

    Soo-ampon, S; Vongsavan, N; Soo-ampon, M; Chuckpaiwong, S; Matthews, B

    2003-05-01

    Records of pulpal blood flow obtained from human teeth with a laser Doppler flowmeter include a very large component derived from periodontal and other tissues outside the pulp, but this contamination can be reduced by covering the surrounding tissues with opaque rubber dam. The present experiments were carried out to determine what proportion of the signal obtained with this dam in place is derived from non-pulpal tissues. Recordings were made from 22 healthy, intact upper incisors in 14 individuals (aged 22-40 years) with and without dam under the following conditions: from the intact teeth, after local anaesthesia (LA) and the preparation of a deep cavity in the incisal third of the labial surface of the tooth, and after removal of the pulp and arrest of bleeding. In some cases, a reading was also made after replacing the pulp in the pulp cavity. The rubber dam reduced significantly (P<0.05) the mean blood flow reading from the intact teeth by 73%, from 6.98 arbitrary perfusion units (PU) (+/-1.30 S.D., n=22) to 1.92+/-1.50 PU. After LA and cavity preparation, the mean signal with dam was 1.45+/-0.61 PU (n=16). This fell significantly by 76% to 0.35+/-0.19 PU (n=16) when the pulp was removed but not replaced, and by 43% to 0.98+/-0.36 PU (n=14) when the pulp was removed and replaced in the pulp cavity. The latter condition is thought to reproduce most closely the scattering of light in an intact tooth. The results confirm previous findings that up to 80% of the laser Doppler blood-flow signal recorded from an intact human tooth without rubber dam is of non-pulpal origin. They also show that only approximately 43% of the signal recorded with an opaque rubber dam is from pulp.

  12. Rotating blade vibration analysis using photogrammetry and tracking laser Doppler vibrometry

    NASA Astrophysics Data System (ADS)

    Gwashavanhu, Benjamin; Oberholster, Abrie J.; Heyns, P. Stephan

    2016-08-01

    Online structural dynamic analysis of turbomachinery blades is conventionally done using contact techniques such as strain gauges for the collection of data. To transfer the captured data from the sensor to the data logging system, installation of telemetry systems is required. This is usually complicated, time consuming and may introduce electrical noise into the data. In addition, contact techniques are intrusive by definition and can introduce significant local mass loading. This affects the integrity of the captured measurements. Advances in technology now allow for the use of optical non-contact methods to analyse the dynamics of rotating structures. These include photogrammetry and tracking laser Doppler vibrometry (TLDV). Various investigations to establish the integrity of photogrammetry measurements for rotating structures involved a comparison to data captured using accelerometers. Discrepancies that were noticed were attributed to the intrusive nature of the contact measurement technique. As an extended investigation, the presented work focuses on the validation of photogrammetry applied to online turbomachinery blade measurements, using TLDV measurements. Through a frequency based characterisation approach of the dynamics of the two scanning mirrors inside the scanning head of a scanning laser Doppler vibrometer (SLDV), TLDV is employed in developing a system that can be used to achieve a perfect circular scan with a Polytec SLDV, (PSV 300). Photogrammetry out-of-plane displacements of a laser dot focused on a specific point on a rotating blade are compared to displacements captured by the laser scanning system. It is shown that there is good correlation between the two measurement techniques when applied to rotating structures, both in the time and frequency domains. The presence of slight discrepancies between the two techniques after elimination of accelerometer based errors illustrated that the optical system noise floor of photogrammetry does

  13. 21 CFR 892.1715 - Full-field digital mammography system.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... planar digital x-ray images of the entire breast. This generic type of device may include digital mammography acquisition software, full-field digital image receptor, acquisition workstation, automatic exposure control, image processing and reconstruction programs, patient and equipment supports,...

  14. 21 CFR 892.1715 - Full-field digital mammography system.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... planar digital x-ray images of the entire breast. This generic type of device may include digital mammography acquisition software, full-field digital image receptor, acquisition workstation, automatic exposure control, image processing and reconstruction programs, patient and equipment supports,...

  15. Measurements in the Turbulent Boundary Layer at Constant Pressure in Subsonic and Supersonic Flow. Part 2: Laser-Doppler Velocity Measurements

    NASA Technical Reports Server (NTRS)

    Dimotakis, P. E.; Collins, D. J.; Lang, D. B.

    1979-01-01

    A description of both the mean and the fluctuating components of the flow, and of the Reynolds stress as observed using a dual forward scattering laser-Doppler velocimeter is presented. A detailed description of the instrument and of the data analysis techniques were included in order to fully document the data. A detailed comparison was made between the laser-Doppler results and those presented in Part 1, and an assessment was made of the ability of the laser-Doppler velocimeter to measure the details of the flows involved.

  16. Mammographic artifacts on full-field digital mammography.

    PubMed

    Choi, Jae Jeong; Kim, Sung Hun; Kang, Bong Joo; Choi, Byung Gil; Song, ByungJoo; Jung, Haijo

    2014-04-01

    This study investigates the incidence of full-field digital mammographic (FFDM) artifacts with three systems at two institutions and compares the artifacts between two detector types and two grid types. A total of 4,440 direct and 4,142 indirect FFDM images were reviewed by two radiologists, and artifacts were classified as patient related, hardware related, and software processing. The overall incidence of FFDM artifacts was 3.4% (292/8,582). Patient related artifacts (motion artifacts and skin line artifacts) were the most commonly detected types (1.7%). Underexposure among hardware related artifacts and high-density artifacts among software processing artifacts also were common (0.7 and 0.5%, respectively). These artifacts, specific to digital mammography, were more common with the direct detector type and the crossed air grid type than with the indirect type and linear grid type (p < 0.05). The most common mammographic artifacts on FFDM were patient related, which might be controlled by the instruction of a patient and technologist. Underexposure and high-density artifacts were more common with direct detector and crossed air type of grid.

  17. Full-field transient vibrometry of the human tympanic membrane by local phase correlation and high-speed holography.

    PubMed

    Dobrev, Ivo; Furlong, Cosme; Cheng, Jeffrey T; Rosowski, John J

    2014-09-01

    Understanding the human hearing process would be helped by quantification of the transient mechanical response of the human ear, including the human tympanic membrane (TM or eardrum). We propose a new hybrid high-speed holographic system (HHS) for acquisition and quantification of the full-field nanometer transient (i.e., >10 kHz) displacement of the human TM. We have optimized and implemented a 2 þ 1 frame local correlation (LC) based phase sampling method in combination with a high-speed (i.e., >40 K fps) camera acquisition system. To our knowledge, there is currently no existing system that provides such capabilities for the study of the human TM. The LC sampling method has a displacement difference of <11 nm relative to measurements obtained by a four-phase step algorithm. Comparisons between our high-speed acquisition system and a laser Doppler vibrometer indicate differences of <10 μs. The high temporal (i.e., >40 kHz) and spatial (i.e., >100 k data points) resolution of our HHS enables parallel measurements of all points on the surface of the TM, which allows quantification of spatially dependent motion parameters, such as modal frequencies and acoustic delays. Such capabilities could allow inferring local material properties across the surface of the TM.

  18. Full-field transient vibrometry of the human tympanic membrane by local phase correlation and high-speed holography

    NASA Astrophysics Data System (ADS)

    Dobrev, Ivo; Furlong, Cosme; Cheng, Jeffrey T.; Rosowski, John J.

    2014-09-01

    Understanding the human hearing process would be helped by quantification of the transient mechanical response of the human ear, including the human tympanic membrane (TM or eardrum). We propose a new hybrid high-speed holographic system (HHS) for acquisition and quantification of the full-field nanometer transient (i.e., >10 kHz) displacement of the human TM. We have optimized and implemented a 2+1 frame local correlation (LC) based phase sampling method in combination with a high-speed (i.e., >40 K fps) camera acquisition system. To our knowledge, there is currently no existing system that provides such capabilities for the study of the human TM. The LC sampling method has a displacement difference of <11 nm relative to measurements obtained by a four-phase step algorithm. Comparisons between our high-speed acquisition system and a laser Doppler vibrometer indicate differences of <10 μs. The high temporal (i.e., >40 kHz) and spatial (i.e., >100 k data points) resolution of our HHS enables parallel measurements of all points on the surface of the TM, which allows quantification of spatially dependent motion parameters, such as modal frequencies and acoustic delays. Such capabilities could allow inferring local material properties across the surface of the TM.

  19. Full-field transient vibrometry of the human tympanic membrane by local phase correlation and high-speed holography

    PubMed Central

    Dobrev, Ivo; Furlong, Cosme; Cheng, Jeffrey T.; Rosowski, John J.

    2014-01-01

    Abstract. Understanding the human hearing process would be helped by quantification of the transient mechanical response of the human ear, including the human tympanic membrane (TM or eardrum). We propose a new hybrid high-speed holographic system (HHS) for acquisition and quantification of the full-field nanometer transient (i.e., >10  kHz) displacement of the human TM. We have optimized and implemented a 2+1 frame local correlation (LC) based phase sampling method in combination with a high-speed (i.e., >40  K fps) camera acquisition system. To our knowledge, there is currently no existing system that provides such capabilities for the study of the human TM. The LC sampling method has a displacement difference of <11  nm relative to measurements obtained by a four-phase step algorithm. Comparisons between our high-speed acquisition system and a laser Doppler vibrometer indicate differences of <10  μs. The high temporal (i.e., >40  kHz) and spatial (i.e., >100  k data points) resolution of our HHS enables parallel measurements of all points on the surface of the TM, which allows quantification of spatially dependent motion parameters, such as modal frequencies and acoustic delays. Such capabilities could allow inferring local material properties across the surface of the TM. PMID:25191832

  20. Experimental Validation of Simulations Using Full-field Measurement Techniques

    SciTech Connect

    Hack, Erwin

    2010-05-28

    The calibration by reference materials of dynamic full-field measurement systems is discussed together with their use to validate numerical simulations of structural mechanics. The discussion addresses three challenges that are faced in these processes, i.e. how to calibrate a measuring instrument that (i) provides full-field data, and (ii) is dynamic; (iii) how to compare data from simulation and experimentation.

  1. 75 FR 68200 - Medical Devices; Radiology Devices; Reclassification of Full-Field Digital Mammography System

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-05

    ... controls). The device type is intended to produce planar digital x-ray images of the entire breast; this... digital x-ray images of the entire breast. This generic type of device may include digital mammography... 892.1715. The final rule uses the term ``planar'' instead of ``full- field'' to describe digital...

  2. Time-domain algorithm for single-photon laser-Doppler flowmetry at large interoptode spacing in human bone.

    PubMed

    Binzoni, Tiziano; Van De Ville, Dimitri; Sanguinetti, Bruno

    2014-10-20

    A new laser-Doppler flowmeter at large interoptode spacing, based on single-photon counting (single-photon laser-Doppler flowmetry [SP-LDF]) and allowing assessment of blood flow deep in bone tissue, is proposed and implemented. To exploit the advantages of the new SP-LDF hardware, a dedicated simple and efficient time-domain algorithm has been developed. The new algorithm is based on the zero-order moment of the power density spectrum of the ad hoc prefiltered photoelectric current. The SP-LDF has been validated by Monte Carlo simulations, as well as by experimental measurements on a bone tissue phantom for optical flowmeters and on human. PMID:25402789

  3. Material properties identification using ultrasonic waves and laser Doppler vibrometer measurements: a multi-input multi-output approach

    NASA Astrophysics Data System (ADS)

    Longo, R.; Vanlanduit, S.; Guillaume, P.

    2013-10-01

    In this paper a multi-input multi-output approach able to determine the material properties of homogeneous materials is presented. To do so, an experimental set-up which combines the use of multi harmonic signals with interleaved frequencies and laser Doppler vibrometer measurements has been developed. A modeling technique, based on transmission and reflection measurements, allowed the simultaneous determination of longitudinal wave velocity, density and thickness of the materials under test with high levels of precision and accuracy.

  4. Laser-Doppler acoustic probing of granular media with in-depth property gradient and varying pore pressures

    SciTech Connect

    Bodet, L.; Dhemaied, A.; Mourgues, R.; Tournat, V.; Rejiba, F.

    2012-05-24

    Non-contacting ultrasonic techniques recently proved to be efficient in the physical modeling of seismic-wave propagation at various application scales, as for instance in the context of geological analogue and seismic modeling. An innovative experimental set-up is proposed here to perform laser-Doppler acoustic probing of unconsolidated granular media with varying pore pressures. The preliminary experiments presented here provide reproducible results and exploitable data, thus validating both the proposed medium preparation and pressure gradient generation procedure.

  5. A comparison of measurements of cerebral blood flow in the rabbit using laser Doppler spectroscopy and radionuclide labelled microspheres.

    PubMed

    Eyre, J A; Essex, T J; Flecknell, P A; Bartholomew, P H; Sinclair, J I

    1988-02-01

    Laser Doppler spectroscopy has been evaluated for the measurement of cerebral blood flow (CBF) by correlation with simultaneous measurements by radionuclide labelled microspheres. The experimental procedures were carried out on five anaesthetised rabbits. The cortical tissue was exposed by means of a small burr hole and illuminated by a helium neon laser (632.8 nm). Reflected light was detected using a silicon photodiode, and CBF was calculated continuously from the power of the frequency weighted Doppler spectrum in the reflected light. Three successive measurements of CBF were made using the microsphere technique. Following an initial baseline measurement, CBF was increased by an infusion of metaraminol and then reduced by controlled haemorrhage. Laser Doppler spectroscopy provided continuous monitoring of blood flow fluctuations and during the haemorrhage it was possible to demonstrate CBF autoregulation until the mean blood pressure fell below 6.7 kPa (50 mmHg). A regression analysis was performed between the simultaneous CBF measurements from the two techniques using a least squares best fit straight line analysis (r = 0.92, P less than 0.001). It was concluded that the flow computed from laser Doppler spectroscopy varied linearly with CBF and offers the unique advantage of continuous and instantaneous measurements even during nonsteady state flow.

  6. Laser Doppler flowmetry for bone blood flow measurements: helium-neon laser light attenuation and depth of perfusion assessment.

    PubMed

    Nötzli, H P; Swiontkowski, M F; Thaxter, S T; Carpenter, G K; Wyatt, R

    1989-01-01

    Laser Doppler flowmetry (LDF) has been successfully used in clinical and experimental settings to evaluate bone perfusion but unanswered questions regarding its capabilities and limitations still remain. This study was undertaken to determine absorption of He-Ne laser light (632.8 nm) and maximum depth for flow assessment (threshold thickness) under optimal conditions in bone. Light transmittance in bovine bone samples of femora and tibia was measured after each step of grinding and depth of penetration calculated. The threshold thickness was obtained by placing the same samples in a flow chamber where a solution of 2% latex circulated beneath; flow was detected by a laser Doppler probe resting on top of the sample. The results showed a significantly higher depth of penetration for trabecular than for cortical bone. A regression analysis showed a high correlation between the inorganic fraction of the bone and the depth of penetration. The maximum depth at which the laser Doppler probe can evaluate flow in bone conditions was found to be 2.9 +/- 0.2 mm in cortical bone, 3.5 +/- 0.3 mm in bone covered by 1 mm cartilage and 3.5 +/- 0.2 mm in trabecular bone. The study showed the limitations of LDF in bone and their correlations to various bone properties.

  7. Physiological effects of indomethacin and celecobix: an S-transform laser Doppler flowmetry signal analysis

    NASA Astrophysics Data System (ADS)

    Assous, S.; Humeau, A.; Tartas, M.; Abraham, P.; L'Huillier, J. P.

    2005-05-01

    Conventional signal processing typically involves frequency selective techniques which are highly inadequate for nonstationary signals. In this paper, we present an approach to perform time-frequency selective processing of laser Doppler flowmetry (LDF) signals using the S-transform. The approach is motivated by the excellent localization, in both time and frequency, afforded by the wavelet basis functions. Suitably chosen Gaussian wavelet functions are used to characterize the subspace of signals that have a given localized time-frequency support, thus enabling a time-frequency partitioning of signals. In this paper, the goal is to study the influence of various pharmacological substances taken by the oral way (celecobix (Celebrex®), indomethacin (Indocid®) and placebo) on the physiological activity behaviour. The results show that no statistical differences are observed in the energy computed from the time-frequency representation of LDF signals, for the myogenic, neurogenic and endothelial related metabolic activities between Celebrex and placebo, and Indocid and placebo. The work therefore proves that these drugs do not affect these physiological activities. For future physiological studies, there will therefore be no need to exclude patients having taken cyclo-oxygenase 1 inhibitions.

  8. Laser Doppler measurement of relative blood velocity in the human optic nerve head.

    PubMed

    Riva, C E; Grunwald, J E; Sinclair, S H

    1982-02-01

    The Doppler shift frequency spectrum (DSFS) of laser light scattered from red blood cells (RBCs) moving in the microcirculation of the optic nerve head has been recorded in normal volunteers by means of a fundus camera laser Doppler velocimeter. The width of the DSFS, which varies in proportion to the speed of the RBCs, has been characterized by a parameter alpha. With the use of a model for the scattering of light by tissue and RBCs and for the RBC velocity distribution, values of alpha recorded at normal intraocular pressure (IOP) suggest that the RBCs that contribute to the Doppler signal are flowing in capillaries. The parameter alpha was found to vary markedly with the IOP and with the phase of the ocular pressure pulse at elevated IOP. The return of the speed of RBCs toward normal, which is observed after a step increase of IOP above normal and after a step decrease below normal, has been attributed to an autoregulatory response of the optic nerve circulation.

  9. Pulse transit times to the capillary bed evaluated by laser Doppler flowmetry

    PubMed Central

    Bernjak, Alan; Stefanovska, Aneta

    2010-01-01

    The pulse transit time (PTT) of a wave over a specified distance along a blood vessel provides a simple non-invasive index that can be used for the evaluation of arterial distensibility. Current methods of measuring the PTT determine the propagation times of pulses only in the larger arteries. We have evaluated the pulse arrival time (PAT) to the capillary bed, through the microcirculation, and have investigated its relationship to the arterial PAT to a fingertip. To do so, we detected cardiac-induced pulse waves in skin microcirculation using laser Doppler flowmetry (LDF). Using the ECG as a reference, PATs to the microcirculation were measured on the four extremities of 108 healthy subjects. Simultaneously, PATs to the radial artery of the left index finger were obtained from blood pressure recordings using a piezoelectric sensor. Both PATs correlate in similar ways with heart rate and age. That to the microcirculation is shown to be sensitive to local changes in skin perfusion induced by cooling. We introduce a measure for the PTT through the microcirculation. We conclude that a combination of LDF and pressure measurements enables simultaneous characterization of the states of the macro and microvasculature. Information about the microcirculation, including an assessment of endothelial function, may be obtained from the responses to perturbations in skin perfusion, such as temperature stress or vasoactive substances. PMID:19202235

  10. CHARACTERIZATION OF AIRFLOWS NEAR THE EXIT OF HVAC REGISTERS USING LASER DOPPLER VELOCIMETRY (LDV).

    SciTech Connect

    TUTU,N.K.; KRISHNA,C.R.; ANDREWS,J.W.; BUTCHER,T.A.

    2003-03-13

    A facility to characterize the airflow at the exit of HVAC registers was designed and fabricated. The objective of this work is to obtain velocity and turbulence data at the exit of registers, which can then be used as an input boundary condition in a modern Computational Fluid Dynamics (CFD) code to predict the velocity and temperature distribution in an enclosure, and also the register performance parameters such as throw. During the course of this work, two commonly used registers were tested. Both registers were 8 inch x 4 inch sidewall registers. Laser Doppler Velocimetry was used to measure the axial and vertical components of the velocity vector at various locations across the face of the registers. For the two cases of registers studied here, the results suggest that the velocity field at the very exit of each of these registers scales with the flow rate through the registers. This means that, in the mode of operation in which the supply fan (of an HVAC system) has a ''High'' and ''Low'' setting, similar velocity scaling would result for the type of registers tested here.

  11. Environmental effects on laser Doppler pulpal blood-flow measurements in man.

    PubMed

    Hartmann, A; Azérad, J; Boucher, Y

    1996-04-01

    The increasing number of experiments using laser Doppler flowmetry in man for pulpal blood-flow recordings leads to questioning of the experimental recording conditions. The present study focused on three points: the design of the laser probe holder, the isolation of the tooth, and the influence of the recording site. A rigid polyurethane splint used in addition to different isolation devices (cotton roll, metal shield, rubber dam) was compared with a silicone splint. The silicone resulted in significantly higher values (+341%) than the polyurethane splint. The combination of the polyurethane splint with isolation devices decreased, in all cases, the flux values. The polyurethane/rubber-dam combination was the most efficient in individualizing the pulpal blood flow (-69% decrease). Recordings on non-vital teeth confirmed the hypothesis that there was periodontal contamination of the recorded flow, as the signal was abolished when using the polyurethane/rubber-dam combination. Cervical recording sites gave significantly higher values than occlusal sites (+42%). It is concluded that, in man, the part played by the periodontium may have been underestimated in previous recordings of pulpal blood flow. The use of a rubber dam in combination with a rigid splint to enhance the validity of recordings is proposed.

  12. Laser-tissue interaction with fs pulses: measurement of the recoil momentum by laser Doppler vibrometry

    NASA Astrophysics Data System (ADS)

    Mittnacht, Dirk; Sessa, Gaetano; Travaglini, Michele; Foth, Hans-Jochen

    2004-06-01

    In the field of otolaryngology a precise contactless treatment of the bones in the middle ear is eligible. For this reason lasers are investgiated for the use in this field. The main risk during laser surgery in the middle ear (e.g. stapedotomy) is the damage of hair cells in the inner ear due to heat diffusion or high pressure fluctuations. While the temperature problem has been resolved by shortening the pulse durations; the transfer of a recoil momentum due to the ablation process rises as another problem. To measure this momentum, special spring plates were designed as vibration disks for the mounting of the tissue. The probes were exposed to amplified Ti:Sapphire laser pulses with a pulse length of 45 fs and a power density up to 5,6×1013 W/cm2. The beam of a laser Doppler vibrometer was focused on backside of the plate to monitor its motion. The results were compared to a damage threshold of hair cells in the inner ear calculated by a literature value for the Sound Pressure Level (SPL)-Threshold. The results lead to SPL values below the critical value of 160 dB. Measurements with higher time resolution and high speed photography are used to approve these results.

  13. Laser-tissue interaction with fs pulses: measurement of the recoil momentum by laser Doppler vibrometry

    NASA Astrophysics Data System (ADS)

    Mittnacht, Dirk, IV; Sessa, Gaetano; Travaglini, Michele; Foth, Hans-Jochen

    2003-10-01

    In the field of otolaryngology a precise contactless treatment of the bones in the middle ear is eligible. For this reason lasers are investigated for the use in this field. The main risk during laser surgery in the middle ear (e.g. stapedotomy) is the damage of hair cells in the inner ear due to heat diffusion or high pressure fluctuations. While the temperature problem has been resolved by shortening the pulse durations; the transfer of a recoil momentum due to the ablation process rises as another problem. To measure this momentum, special spring plates were designed as vibration disks for the mounting of the tissue. The probes were exposed to amplified Ti:Sapphire Laser pulses with a pulse length of 100fs and a power density up to 6,4*1013W/cm2. The beam of a Laser Doppler Vibrometer was focused on backside of the plate to monitor its motion. The results were compared to a damage threshold of hair cells in the inner ear calculated by a literature value for the Sound Pressure Level (SPL)-Threshold. The first results lead to SPL values below the critical value but measurements with a higher time resolution are necessary to verify this conclusion.

  14. Three-dimensional laser Doppler anemometer measurements of a jet in a crossflow

    NASA Technical Reports Server (NTRS)

    Snyder, P.; Orloff, K. L.

    1984-01-01

    A three-dimensional laser Doppler anemometer (3D-LDA) was used in a wind tunnel to measure a jet in a crossflow. Measurements were made in the vicinity of a 5-cm-diam jet which issued normally into a 10.65 m/sec wind tunnel crossflow; the velocity ratio Vjet/Vinf was 8. Detailed lateral surveys were made at two elevations (z = cm and 2 cm); both elevations were within the region affected by the boundary layer on the plate. The results are believed to provide reliable velocity field information in the boundary layer of the jet in a crossflow. Turbulence information also is available and believed to be roughly correct, although it may be subject to broadening effects for the lower values of turbulence. A weak vortex pair was observed in the wake at the plate surface. This structure existed in the boundary layer and built confidence because the 3D-LDA was, indeed, able to resolve fine detail in the wake. The capabilities of the 3D-LDA not only allow the making of the velocity surveys, but can be utilized to follow mean streamlines in the flow.

  15. Frescoes diagnostic using laser Doppler vibrometry and infrared thermography: experimental and numerical approaches

    NASA Astrophysics Data System (ADS)

    Agnani, Alexia; De Andrade, Roberto M.; Esposito, Enrico; Feligiotti, Mara; Tavares, Sinthya G.

    2006-06-01

    In this work laser Doppler vibrometry has been used for damage detection in frescoes. Results were compared with the ones obtained through infrared thermography, and, for both techniques, mathematical models were implemented to simulate the physical domains and conditions of the employed test sample. The limitations of each methodology are also discussed. The numerical model of the vibrometric investigations has been constructed using Finite Elements Method modeling. A new procedure based on the observation of Rayleigh waves propagation velocities allowed to acquire sample mechanical parameters. Comparison of experimental and simulated data and independent defect diameter measurement by echographic equipment, allowed to establish the confidence level and the discrepancies in the developed model. Also operational limits of the vibrometric technique have been studied by acquisition of Signal-to-Noise ratio on different areas of a sample. The Fourier equation has been used for the mathematical model employed for the numerical simulation of the thermographic investigations. Numerical technique with formularization in finite volumes has been employed and a FORTRAN code has been developed to solve the thermal problem.

  16. Dual-frequency laser Doppler velocimeter for speckle noise reduction and coherence enhancement.

    PubMed

    Cheng, Chih-Hao; Lee, Chia-Wei; Lin, Tzu-Wei; Lin, Fan-Yi

    2012-08-27

    We study the characteristics of a dual-frequency laser Doppler velocimeter (DF-LDV) based on an optically injected semiconductor laser. The laser operated in a period-one (P1) dynamical state with two optical frequencies separated by 11.25 GHz is used as the dual-frequency light source. With a microwave beat signal carried by the light, the DF-LDV possesses both the advantages of good directionality, high intensity, and high spatial resolution from the light and low speckle noise and good coherence from the microwave, respectively. By phase-locking the two frequency components with a microwave signal, the coherence of the dual-frequency light source can be further improved and the detection range can be much extended. In this paper, velocity resolutions of the DF-LDV with different amounts of speckle noise and at different detection ranges are experimentally measured and analyzed. Compared with the conventional single-frequency LDV (SF-LDV), the velocity resolution of the DF-LDV is improved by 8 × 10(3) times from 2.5 m/s to 0.31 mm/s for a target with a longitudinal velocity vz = 4 cm/s, a transverse velocity vt = 5 m/s, and at a detection range of 108 m.

  17. Identification of pavement material properties using a scanning laser Doppler vibrometer

    NASA Astrophysics Data System (ADS)

    Hasheminejad, Navid; Vuye, Cedric; Van den Bergh, Wim; Dirckx, Joris; Leysen, Jari; Sels, Seppe; Vanlanduit, Steve

    2016-06-01

    This paper presents an inverse modeling approach to estimate mechanical properties of asphalt concrete (i.e. Young's modulus E, Poisson ratio ν and damping coefficients). Modal analysis was performed on an asphalt slab using a shaker to excite the specimen and an optical measurement system (a Scanning Laser Doppler Vibrometer or SLDV) to measure the velocity of a measurement grid on the surface of the slab. The SLDV has the ability to measure the vibration pattern of an object with high accuracy, short testing time and without making any contact. The measured data were used as inputs for a frequency domain model parameter estimation method (the Polymax estimator). Meanwhile, natural frequencies and damping ratios of the system were calculated using a Finite Element Modeling (FEM) method. Then, the Modal Assurance Criterion (MAC) was used to pair the mode shapes of the structure determined by measurements and estimated by FEM. By changing the inputs of the FEM analysis (E, ν and damping coefficients of the material) iteratively and minimizing the discrepancy between paired natural frequencies and damping ratios of the system estimated using the Polymax estimator and calculated by FEM, the Young's modulus, Poisson ratio and damping coefficients of the asphalt slab were estimated.

  18. Laser Doppler flowmetry: in the assessment of peripheral vascular disorders? A preliminary evaluation.

    PubMed

    Cochrane, T; Sheriff, S B; Boulton, A J; Ward, J D; Atkins, R M

    1986-02-01

    Skin is a representative microvascular bed providing easy access for the study of capillary haemodynamics. In this preliminary evaluation we have used laser Doppler flowmetry to measure the response of skin capillary blood flow to local thermal stimulation. The purpose of our study was to see if such measurements can be used to derive useful clinical information. Thirty subjects, 15 male and 15 female, were selected to establish "normal' patterns of behaviour. All normal subjects studied showed similar patterns of response. There was a slight downward trend in red-blood-cell flux with age. Periods of vasomotor activity were present at rates ranging from 4-17 cycles/min. The mean temperature rise in the heated skin area was 4 degrees C. Blood flow over this range increased by a factor of 10 or more. Clinical cases studied were strictly limited to three categories of disease with known or suspected microvascular changes: algodystrophy, lower-limb ischaemia and diabetic neuropathy. All the clinical cases studied showed deviations from the normal pattern. Patients with algodystrophy had impaired peripheral vascular function in the affected area. Patients with lower-limb ischaemic problems all had poor peripheral perfusion. In the limited number of diabetic neuropathic feet studied two patterns emerged: patients with no evidence of ulceration displayed striking vasomotor activity; those with more severe problems had reduced red-blood-cell flux and little evidence of vasomotor control.

  19. Translational and Brownian motion in laser-Doppler flowmetry of large tissue volumes.

    PubMed

    Binzoni, T; Leung, T S; Seghier, M L; Delpy, D T

    2004-12-21

    This study reports the derivation of a precise mathematical relationship existing between the different p-moments of the power spectrum of the photoelectric current, obtained from a laser-Doppler flowmeter (LDF), and the red blood cell speed. The main purpose is that both the Brownian (defining the 'biological zero') and the translational movements are taken into account, clarifying in this way what the exact contribution of each parameter is to the LDF derived signals. The derivation of the equations is based on the quasi-elastic scattering theory and holds for multiple scattering (i.e. measurements in large tissue volumes and/or very high red blood cell concentration). The paper also discusses why experimentally there exists a range in which the relationship between the first moment of the power spectrum and the average red blood cells speed may be considered as 'linear' and what are the physiological determinants that can result in nonlinearity. A correct way to subtract the biological zero from the LDF data is also proposed. The findings should help in the design of improved LDF instruments and in the interpretation of experimental data.

  20. Toward a velocity-resolved microvascular blood flow measure by decomposition of the laser Doppler spectrum.

    PubMed

    Larsson, Marcus; Strömberg, Tomas

    2006-01-01

    Tissue microcirculation, as measured by laser Doppler flowmetry (LDF), comprises capillary, arterial, and venous blood flow. With the classical LDF approach, it has been impossible to differentiate between different vascular compartments. We suggest an alternative LDF algorithm that estimates at least three concentration measures of flowing red blood cells (RBCs), each associated with a predefined, physiologically relevant, absolute velocity in millimeters per second. As the RBC flow velocity depends on the dimension of the blood vessel, this approach might enable a microcirculatory flow differentiation. The LDF concentration estimates are derived by fitting predefined Monte Carlo simulated, single-velocity spectra to a measured, multiple-velocity LDF spectrum. Validation measurements, using both single- and double-tube flow phantoms perfused with a microsphere solution, show that it is possible to estimate velocity and concentration changes, and to differentiate between flows with different velocities. Our theory is also applied to RBC flow measurements. A Gegenbauer kernel phase function (alpha(gk)=1.05; g(gk)=0.93), with an anisotropy factor of 0.987 at 786 nm, is found suitable for modeling Doppler scattering by RBCs diluted in physiological saline. The method is developed for low concentrations of RBCs, but can in theory be extended to cover multiple Doppler scattering. PMID:16526901

  1. Development of JSNS target vessel diagnosis system using laser Doppler method

    NASA Astrophysics Data System (ADS)

    Teshigawara, M.; Wakui, T.; Naoe, T.; Kogawa, H.; Maekawa, F.; Futakawa, M.; Kikuchi, K.

    2010-03-01

    When an intense pulsed proton beam with a power of 1 MW is irradiated to a mercury target, a pressure wave caused by the proton beam gives a vibration on the target vessel. Pitting damage also occurs on the target vessel, especially incident beam area, resulting in shortening of a life-time. It is very important to monitor the vibration of the target vessel from the view point of the life-time estimation. We developed the target vessel diagnosis system using laser Doppler method and successfully installed it in an actual pulsed spallation source. The diagnosis system consists of retro-reflecting corner-cube mirror (reflective mirror) on the target, mirror assembly in a reflector plug and laser source-detector. The newly developed reflective mirror, made by nickel, was installed by vacuum silver brazing on the target vessel to detect the target vibration. In order to pass the laser beam to the target vessel, a mirror assembly was installed inside the reflector plug. It is replaceable using a remote handling machine during a maintenance period. Nd-YAG laser beam (wave length: 533 nm) with the power of 50 mW was adopted to detect the target vibration. The first proton beam to the target in the spallation neutron source (JSNS) was provided on 30 May 2008. The first signal related to the target vibration was also detected by using this target vessel diagnosis system.

  2. Reproducibility of transcutaneous oximetry and laser Doppler flowmetry in facial skin and gingival tissue.

    PubMed

    Svalestad, J; Hellem, S; Vaagbø, G; Irgens, A; Thorsen, E

    2010-01-01

    Laser Doppler flowmetry (LDF) and transcutaneous oximetry (TcPO(2)) are non-invasive techniques, widely used in the clinical setting, for assessing microvascular blood flow and tissue oxygen tension, e.g. recording vascular changes after radiotherapy and hyperbaric oxygen therapy. With standardized procedures and improved reproducibility, these methods might also be applicable in longitudinal studies. The aim of this study was to evaluate the reproducibility of facial skin and gingival LDF and facial skin TcPO(2). The subjects comprised ten healthy volunteers, 5 men, aged 31-68 years. Gingival perfusion was recorded with the LDF probe fixed to a custom made, tooth-supported acrylic splint. Skin perfusion was recorded on the cheek. TcPO(2) was recorded on the forehead and cheek and in the second intercostal space. The reproducibility of LDF measurements taken after vasodilation by heat provocation was greater than for basal flow in both facial skin and mandibular gingiva. Pronounced intraday variations were observed. Interweek reproducibility assessed by intraclass correlation coefficient ranged from 0.74 to 0.96 for LDF and from 0.44 to 0.75 for TcPO(2). The results confirm acceptable reproducibility of LDF and TcPO(2) in longitudinal studies in a vascular laboratory where subjects serve as their own controls. The use of thermoprobes is recommended. Repeat measurements should be taken at the same time of day.

  3. Quantification of sympathetic vascular responses in skin by laser Doppler flowmetry.

    PubMed

    Khan, F; Spence, V A; Wilson, S B; Abbot, N C

    1991-05-01

    An improved physiological test of focal sympathetic nervous function using a laser Doppler flowmeter is presented. The test evaluates rapid reflex changes in skin blood flow at the finger tip where there are abundant arteriovenous anastomoses with dense sympathetic innervation. Indirect body heating was employed in all subjects to induce central vasodilation and to obtain stable comparable finger tip blood flows prior to stimulus. The reflex vasoconstriction which occurs following inspiratory gasp and contralateral hand cold challenge was quantified and its reproducibility investigated on three separate occasions in 20 young subjects. The variability in responses both within and between young subjects was small. The test was applied to 10 diabetic patients with autonomic neuropathy and to 10 age-matched control subjects. Vasoconstrictor reflexes were significantly lower in the diabetic group (p less than 0.005) with responses lower than 2 SD from the mean for age-matched controls. In conclusion, the test provides an assessment of focal autonomic damage which can be applied to other regions of the body rich in arteriovenous anastomoses and may have application in clinical studies investigating autonomic activity. PMID:2060997

  4. Population pharmacokinetic/pharmacodynamic modeling of histamine response measured by histamine iontophoresis laser Doppler.

    PubMed

    Liu, Xiaoxi; Jones, Bridgette L; Roberts, Jessica K; Sherwin, Catherine M

    2016-08-01

    The epicutaneous histamine (EH) test is the current gold standard method for the clinical evaluation of allergic conditions. However, the EH method is limited in providing an objective and qualitative assessment of histamine pharmacodynamic response. The histamine iontophoresis with laser Doppler (HILD) monitoring method, an alternative method, allows a fixed dose of histamine to be delivered and provides an objective, continuous, and dynamic measurement of histamine epicutaneous response in children and adults. However, due to the high sampling frequency (up to 40 Hz), the output files are usually too cumbersome to be directly used for further analysis. In this study, we developed an averaging algorithm that efficiently reduces the HILD data in size. The reduced data was further analyzed and a population linked effect pharmacokinetic/pharmacodynamic (PK/PD) model was developed to describe the local histamine response. The model consisted of a one-compartment PK model and a direct-response fractional maximum effect (Emax) model. The parameter estimates were obtained as follows: absorption rate constant (ka), 0.094/min; absorption lag time (Tlag), 2.72 min; partitioning clearance from local depot to systemic circulation (CLpar), 0.0006 L/min; baseline effect (E0), 13.1 flux unit; Emax, 13.4; concentration at half maximum effect (EC50) 31.1 mg/L. Covariate analysis indicated that age and race had significant influence on Tlag and EC50, respectively.

  5. Percutaneous penetration of methyl nicotinate from ointments using the laser Doppler technique: bioequivalence and enhancer effects.

    PubMed

    Remane, Yvonne; Leopold, Claudia S; Maibach, Howard I

    2006-12-01

    Laser Doppler flowmetry (LDF) may be used to quantify erythema response as a result of an increased cutaneous microcirculation induced by methyl nicotinate (MN). Bioequivalence of a test and a standard preparation (vehicles: light mineral oil and medium chain triglycerides, respectively) was confirmed according to the pilot study of the FDA Guidance for Industry "Topical dermatologic corticosteroids: In Vivo bioequivalence" applying the staggered application and synchronized removal method for one defined concentration. Furthermore, the influence of penetration enhancers (5% w/w Dimethylsulfoxide (DMSO) and 10% w/w diethylene glycol monoethyl ether) on MN penetration was investigated. It was shown that DMSO and diethylene glycol monoethyl ether altered cutaneous microcirculation and thus MN penetration in comparison to the standard formulation. However, true penetration enhancement could only be proved with diethylene glycol monoethyl ether resulting from an improved drug solubility in the skin which was confirmed by attenuated total reflectance fourier transform infrared spectroscopy (ATR-FTIR). Increased MN penetration by DMSO was only caused by thermodynamic effects, i.e. a decreased drug solubility in the vehicle.

  6. Comparison of NIRS, laser Doppler flowmetry, photoplethysmography, and pulse oximetry during vascular occlusion challenges.

    PubMed

    Abay, T Y; Kyriacou, P A

    2016-04-01

    Monitoring changes in blood volume, blood flow, and oxygenation in tissues is of vital importance in fields such as reconstructive surgery and trauma medicine. Near infrared spectroscopy (NIRS), laser Doppler (LDF) flowmetry, photoplethysmography (PPG), and pulse oximetry (PO) contribute to such fields due to their safe and noninvasive nature. However, the techniques have been rarely investigated simultaneously or altogether. The aim of this study was to investigate all the techniques simultaneously on healthy subjects during vascular occlusion challenges. Sensors were attached on the forearm (NIRS and LDF) and fingers (PPG and PO) of 19 healthy volunteers. Different degrees of vascular occlusion were induced by inflating a pressure cuff on the upper arm. The responses of tissue oxygenation index (NIRS), tissue haemoglobin index (NIRS), flux (LDF), perfusion index (PPG), and arterial oxygen saturation (PO) have been recorded and analyzed. Moreover, the optical densities were calculated from slow varying dc PPG, in order to distinguish changes in venous blood volumes. The indexes showed significant changes (p  <  0.05) in almost all occlusions, either venous or over-systolic occlusions. However, differentiation between venous and arterial occlusion by LDF may be challenging and the perfusion index (PI) may not be adequate to indicate venous occlusions. Optical densities may be an additional tool to detect venous occlusions by PPG.

  7. Beam pointing angle optimization and experiments for vehicle laser Doppler velocimetry

    NASA Astrophysics Data System (ADS)

    Fan, Zhe; Hu, Shuling; Zhang, Chunxi; Nie, Yanju; Li, Jun

    2015-10-01

    Beam pointing angle (BPA) is one of the key parameters that affects the operation performance of the laser Doppler velocimetry (LDV) system. By considering velocity sensitivity and echo power, for the first time, the optimized BPA of vehicle LDV is analyzed. Assuming mounting error is within ±1.0 deg, the reflectivity and roughness are variable for different scenarios, the optimized BPA is obtained in the range from 29 to 43 deg. Therefore, velocity sensitivity is in the range of 1.25 to 1.76 MHz/(m/s), and the percentage of normalized echo power at optimized BPA with respect to that at 0 deg is greater than 53.49%. Laboratory experiments with a rotating table are done with different BPAs of 10, 35, and 66 deg, and the results coincide with the theoretical analysis. Further, vehicle experiment with optimized BPA of 35 deg is conducted by comparison with microwave radar (accuracy of ±0.5% full scale output). The root-mean-square error of LDV's results is smaller than the Microstar II's, 0.0202 and 0.1495 m/s, corresponding to LDV and Microstar II, respectively, and the mean velocity discrepancy is 0.032 m/s. It is also proven that with the optimized BPA both high velocity sensitivity and acceptable echo power can simultaneously be guaranteed.

  8. A multi-point laser Doppler vibrometer with fiber-based configuration

    SciTech Connect

    Yang, C.; Guo, M.; Liu, H.; Yan, K.; Xu, Y. J.; Fu, Y.; Miao, H.

    2013-12-15

    Laser Doppler vibrometer (LDV) is a non-contact optical interferometric system to measure vibrations of structures and machines with a high precision. Normal LDV can only offer a single-point measurement. Scanning LDV is usually impractical to do measurement on transient events. In this paper, a fiber-based self-synchronized multi-point LDV is proposed. The multiple laser beams with different frequency shifts are generated from one laser source. The beams are projected onto a vibrating object, reflected and interfered with a common reference beam. The signal including vibration information of multiple spatial points is captured by one single-pixel photodetector. The optical system is mainly integrated by fiber components for flexibility in measurement. Two experiments are conducted to measure a steady-state simple harmonic vibration of a cantilever beam and a transient vibration of a beam clamped at both ends. In the first measurement, a numerical interpolation is applied to reconstruct the mode shape with increased number of data points. The vibration mode obtained is compared with that from FEM simulation. In transient vibration measurement, the first five resonant frequencies are obtained. The results show the new-reported fiber-based multipoint LDV can offer a vibration measurement on various spatial points simultaneously. With the flexibility of fiber configuration, it becomes more practical for dynamic structural evaluation in industrial areas.

  9. Accurate estimation of normal incidence absorption coefficients with confidence intervals using a scanning laser Doppler vibrometer

    NASA Astrophysics Data System (ADS)

    Vuye, Cedric; Vanlanduit, Steve; Guillaume, Patrick

    2009-06-01

    When using optical measurements of the sound fields inside a glass tube, near the material under test, to estimate the reflection and absorption coefficients, not only these acoustical parameters but also confidence intervals can be determined. The sound fields are visualized using a scanning laser Doppler vibrometer (SLDV). In this paper the influence of different test signals on the quality of the results, obtained with this technique, is examined. The amount of data gathered during one measurement scan makes a thorough statistical analysis possible leading to the knowledge of confidence intervals. The use of a multi-sine, constructed on the resonance frequencies of the test tube, shows to be a very good alternative for the traditional periodic chirp. This signal offers the ability to obtain data for multiple frequencies in one measurement, without the danger of a low signal-to-noise ratio. The variability analysis in this paper clearly shows the advantages of the proposed multi-sine compared to the periodic chirp. The measurement procedure and the statistical analysis are validated by measuring the reflection ratio at a closed end and comparing the results with the theoretical value. Results of the testing of two building materials (an acoustic ceiling tile and linoleum) are presented and compared to supplier data.

  10. Non-contact measurement of facial surface vibration patterns during singing by scanning laser Doppler vibrometer

    PubMed Central

    Kitamura, Tatsuya; Ohtani, Keisuke

    2015-01-01

    This paper presents a method of measuring the vibration patterns on facial surfaces by using a scanning laser Doppler vibrometer (LDV). The surfaces of the face, neck, and body vibrate during phonation and, according to Titze (2001), these vibrations occur when aerodynamic energy is efficiently converted into acoustic energy at the glottis. A vocalist's vibration velocity patterns may therefore indicate his or her phonatory status or singing skills. LDVs enable laser-based non-contact measurement of the vibration velocity and displacement of a certain point on a vibrating object, and scanning LDVs permit multipoint measurements. The benefits of scanning LDVs originate from the facts that they do not affect the vibrations of measured objects and that they can rapidly measure the vibration patterns across planes. A case study is presented herein to demonstrate the method of measuring vibration velocity patterns with a scanning LDV. The objective of the experiment was to measure the vibration velocity differences between the modal and falsetto registers while three professional soprano singers sang sustained vowels at four pitch frequencies. The results suggest that there is a possibility that pitch frequency are correlated with vibration velocity. However, further investigations are necessary to clarify the relationships between vibration velocity patterns and phonation status and singing skills. PMID:26579054

  11. Vibration Mode Observation of Piezoelectric Disk-type Resonator by High Frequency Laser Doppler Vibrometer

    NASA Astrophysics Data System (ADS)

    Matsumura, Takeshi; Esashi, Masayoshi; Harada, Hiroshi; Tanaka, Shuji

    For future mobile phones based on cognitive radio technology, a compact multi-band RF front-end architecture is strongly required and an integrated multi-band RF filter bank is a key component in it. Contour-mode resonators are receiving increased attention for a multi-band filter solution, because its resonant frequency is mainly determined by its size and shape, which are defined by lithography. However, spurious responses including flexural vibration are also excited due to its thin structure. To improve resonator performance and suppress spurious modes, visual observation with a laser probe system is very effective. In this paper, we have prototyped a mechanically-coupled disk-array filter, which consists of a Si disk and 2 disk-type resonators of higher-order wine-glass mode, and observed its vibration modes using a high-frequency laser-Doppler vibrometer (UHF-120, Polytec, Inc.). As a result, it was confirmed that higher order wine-glass mode vibration included a compound displacement, and that its out-of-plane vibration amplitude was much smaller than other flexural spurious modes. The observed vibration modes were compared with FEM (Finite Element Method) simulation results. In addition, it was also confirmed that the fabrication error, e.g. miss-alignment, induced asymmetric vibration.

  12. Schlieren laser Doppler flowmeter for the human optical nerve head with the flicker stimuli

    NASA Astrophysics Data System (ADS)

    Geiser, Martial H.; Truffer, Frederic; Evequoz, Hugo; Khayi, Hafid; Mottet, Benjamin; Chiquet, Christophe

    2013-12-01

    We describe a device to measure blood perfusion for the human optic nerve head (ONH) based on laser Doppler flowmetry (LDF) with a flicker stimuli of the fovea region. This device is self-aligned for LDF measurements and includes near-infrared pupil observation, green illumination, and observation of the ONH. The optical system of the flowmeter is based on a Schlieren arrangement which collects only photons that encounter multiple scattering and are back-scattered out of the illumination point. LDF measurements are based on heterodyne detection of Doppler shifted back-scattered light. We also describe an automated analysis of the LDF signals which rejects artifacts and false signals such as blinks. By using a Doppler simulator consisting of a lens and a rotating diffusing wheel, we demonstrate that velocity and flow vary linearly with the speed of the wheel. A cohort of 12 healthy subjects demonstrated that flicker stimulation induces an increase of 17.8% of blood flow in the ONH.

  13. Verification and validation of a patient simulator for test and evaluation of a laser doppler vibrometer

    NASA Astrophysics Data System (ADS)

    Byrd, Kenneth A.; Yauger, Sunny

    2012-06-01

    In the medical community, patient simulators are used to educate and train nurses, medics and doctors in rendering dierent levels of treatment and care to various patient populations. Students have the opportunity to perform real-world medical procedures without putting any patients at risk. A new thrust for the U.S. Army RDECOM CERDEC Night Vision and Electronic Sensors Directorate (NVESD), is the use of remote sensing technologies to detect human vital signs at stando distances. This capability will provide medics with the ability to diagnose while under re in addition to helping them to prioritize the care and evacuation of battleeld casualties. A potential alternative (or precursor) to human subject testing is the use of patient simulators. This substitution (or augmenting) provides a safe and cost eective means to develop, test, and evaluate sensors without putting any human subjects at risk. In this paper, we present a generalized framework that can be used to accredit patient simulator technologies as human simulants for remote physiological monitoring (RPM). Results indicate that we were successful in using a commercial Laser Doppler Vibrometer (LDV) to exploit pulse and respiration signals from a SimMan 3G patient simulator at stando (8 meters).

  14. Absorption and scattering coefficient dependence of laser-Doppler flowmetry models for large tissue volumes.

    PubMed

    Binzoni, T; Leung, T S; Rüfenacht, D; Delpy, D T

    2006-01-21

    Based on quasi-elastic scattering theory (and random walk on a lattice approach), a model of laser-Doppler flowmetry (LDF) has been derived which can be applied to measurements in large tissue volumes (e.g. when the interoptode distance is >30 mm). The model holds for a semi-infinite medium and takes into account the transport-corrected scattering coefficient and the absorption coefficient of the tissue, and the scattering coefficient of the red blood cells. The model holds for anisotropic scattering and for multiple scattering of the photons by the moving scatterers of finite size. In particular, it has also been possible to take into account the simultaneous presence of both Brownian and pure translational movements. An analytical and simplified version of the model has also been derived and its validity investigated, for the case of measurements in human skeletal muscle tissue. It is shown that at large optode spacing it is possible to use the simplified model, taking into account only a 'mean' light pathlength, to predict the blood flow related parameters. It is also demonstrated that the 'classical' blood volume parameter, derived from LDF instruments, may not represent the actual blood volume variations when the investigated tissue volume is large. The simplified model does not need knowledge of the tissue optical parameters and thus should allow the development of very simple and cost-effective LDF hardware.

  15. Dynamic Rotor Deformation and Vibration Monitoring Using a Non-Incremental Laser Doppler Distance Sensor

    SciTech Connect

    Pfister, Thorsten; Guenther, Philipp; Dreier, Florian; Czarske, Juergen

    2010-05-28

    Monitoring rotor deformations and vibrations dynamically is an important task for improving the safety and the lifetime as well as the energy efficiency of motors and turbo machines. However, due to the high rotor speed encountered in particular at turbo machines, this requires concurrently a high measurement rate and high accuracy, which can not be fulfilled by most commercially available sensors. To solve this problem, we developed a non-incremental laser Doppler distance sensor (LDDS), which is able to measure simultaneously the in-plane velocity and the out-of-plane position of moving rough solid objects with micrometer precision. In addition, this sensor concurrently offers a high temporal resolution in the microsecond range, because its position uncertainty is in principle independent of the object velocity in contrast to conventional distance sensors, which is a unique feature of the LDDS. Consequently, this novel sensor enables precise and dynamic in-process deformation and vibration measurements on rotating objects, such as turbo machine rotors, even at very high speed. In order to evidence the capability of the LDDS, measurements of rotor deformations (radial expansion), vibrations and wobbling motions are presented at up to 50,000 rpm rotor speed.

  16. Photo-vibrational spectroscopy of solid and liquid chemicals using laser Doppler vibrometer.

    PubMed

    Hu, Qi; Lim, Jacob Song Kiat; Liu, Huan; Fu, Yu

    2016-08-22

    Photoacoustic/photothermal spectroscopy is an established technique for trace detection of chemicals and explosives. However, prior sample preparation is required and the analysis is conducted in a sealed space with a high-sensitivity microphone or a piezo sensor coupled with a lock-in amplifier, limiting the technique to applications in a laboratory environment. Due to the aforementioned requirements, traditionally this technique may not be suitable for defense and security applications where the detection of explosives or hazardous chemicals is required in an open environment at a safe standoff distance. In this study, chemicals in various forms (membrane, powder and liquid) were excited by an intensity-modulated quantum cascade laser (QCL), while a laser Doppler vibrometer (LDV) based on the Mach-Zehnder interferometer was applied to detect the vibration signal resulting from the photocoustic/photothermal effect. The photo-vibrational spectrum obtained by scanning the QCL's wavelength in MIR range, coincides well with the corresponding spectrum obtained using typical FTIR equipment. The experiment demonstrated that the LDV is a capable sensor for applications in photoacoustic/photothermal spectroscopy, with potential to enable the detection of chemicals in open environment at safe standoff distance. PMID:27557194

  17. Serial assessment of laser Doppler flow during acute pain crises in sickle cell disease

    PubMed Central

    Shi, Patricia Ann; Manwani, Deepa; Olowokure, Olugbenga; Nandi, Vijay

    2014-01-01

    Changes in basal laser Doppler flowmetry (LDF) of skin blood flow in sickle cell disease are reported to have pathophysiologic relevance in pain crisis. This is the first study to strictly control for LDF variability in determining the value of serial, basal (unprovoked) skin LDF as a practical method to assess resolution of acute pain crisis in sickle cell patients. Daily LDF measurements were repeated on the exact same skin areas of the calf and forehead throughout each of 12 hospital admissions for uncomplicated acute pain crisis. A progressive increase in perfusion was observed in the calf throughout hospitalization as pain crisis resolved, but measurement reproducibility in the calf was poor. Reproducibility in the forehead was better, but no significant trend over time in perfusion was seen. There was no significant correlation between perfusion and pain scores over time. There was also no significant pattern of LDF oscillations over time. In conclusion, only perfusion units and not oscillatory pattern of LDF has probable pathophysiological significance in sickle cell disease vaso-occlusion. The reproducibility of basal skin LDF specifically in sickle cell disease needs to be confirmed. PMID:24857171

  18. Measurement of velocities in gas-liquid two-phase flow using Laser Doppler Velocimetry

    SciTech Connect

    Vassallo, P.F.; Trabold, T.A.; Moore, W.E.; Kirouac, G.J.

    1992-09-01

    Measurements of bubble and liquid velocities in two-phase flow have been made using a new forward/backward scattering Laser Doppler Velocimetry (LDV) technique. This work was performed in a 6.4 by 11.1 mm vertical duct using known air/water mixtures. A standard LDV fiber optic probe was used to measure the bubble velocity, using direct backscattered light. A novel retro-reflector and lens assembly permitted the same probe to measure the liquid velocity with direct forward-scattered light. The bubble velocity was confirmed by independent measurements with a high-speed video system. The liquid velocity was confirmed by demonstrating the dominance of the liquid seed data rate in the forward-scatter measurement. Experimental data are presented to demonstrate the accuracy of the technique for a wide range of flow conditions, from bubbles as small as 0.75-mm-diam to slugs as large as 10-mm wide by 30-mm long. In the slug regime, the LDV technique performed velocity measurements for both phases, for void fractions up to 50%, which was the upper limit of our experimental investigation.

  19. Laser Doppler anemometry measurements of steady flow through two bi-leaflet prosthetic heart valves

    PubMed Central

    Bazan, Ovandir; Ortiz, Jayme Pinto; Vieira Junior, Francisco Ubaldo; Vieira, Reinaldo Wilson; Antunes, Nilson; Tabacow, Fabio Bittencourt Dutra; Costa, Eduardo Tavares; Petrucci Junior, Orlando

    2013-01-01

    Introduction In vitro hydrodynamic characterization of prosthetic heart valves provides important information regarding their operation, especially if performed by noninvasive techniques of anemometry. Once velocity profiles for each valve are provided, it is possible to compare them in terms of hydrodynamic performance. In this first experimental study using laser doppler anemometry with mechanical valves, the simulations were performed at a steady flow workbench. Objective To compare unidimensional velocity profiles at the central plane of two bi-leaflet aortic prosthesis from St. Jude (AGN 21 - 751 and 21 AJ - 501 models) exposed to a steady flow regime, on four distinct sections, three downstream and one upstream. Methods To provide similar conditions for the flow through each prosthesis by a steady flow workbench (water, flow rate of 17L/min. ) and, for the same sections and sweeps, to obtain the velocity profiles of each heart valve by unidimensional measurements. Results It was found that higher velocities correspond to the prosthesis with smaller inner diameter and instabilities of flow are larger as the section of interest is closer to the valve. Regions of recirculation, stagnation of flow, low pressure, and flow peak velocities were also found. Conclusions Considering the hydrodynamic aspect and for every section measured, it could be concluded that the prosthesis model AGN 21 - 751 (RegentTM) is superior to the 21 AJ - 501 model (Master Series). Based on the results, future studies can choose to focus on specific regions of the these valves. PMID:24598950

  20. Modal parameter determination of a lightweight aerospace panel using laser Doppler vibrometer measurements

    NASA Astrophysics Data System (ADS)

    de Sousa, Kleverson C.; Domingues, Allan C.; Pereira, Pedro P. de S.; Carneiro, Sergio H.; de Morais, Marcus V. G.; Fabro, Adriano T.

    2016-06-01

    The experimental determination of modal parameters, i.e. natural frequencies, mode shapes and damping ratio, are key in characterizing the dynamic behaviour of structures. Typically, such parameters are obtained from dynamic measurements using one or a set of accelerometers, for response measurements, along with force transducers from an impact hammer or an electrodynamic actuator, i.e. a shaker. However, lightweight structures, commonly applied in the aerospace industry, can be significantly affected by the added mass from accelerometers. Therefore, non-contact measurement techniques, like Laser Doppler Vibrometer (LDV), are a more suitable approach in determining the dynamic characteristics of such structures. In this article, the procedures and results of a modal test for a honeycomb sandwich panel for aerospace applications are presented and discussed. The main objectives of the test are the identification of natural frequencies and mode shapes in order to validate a numerical model, as well as the identification of the damping characteristics of the panel. A validated numerical model will be necessary for future detailed response analysis of the satellite, including vibroacoustic investigations to account for acoustic excitations encountered during launching. The numerical model using homogenised material properties is updated to fit the experimental results and very good agreement between experimental and numerically obtained natural frequencies and mode shapes.

  1. Serial assessment of laser Doppler flow during acute pain crises in sickle cell disease.

    PubMed

    Shi, Patricia Ann; Manwani, Deepa; Olowokure, Olugbenga; Nandi, Vijay

    2014-12-01

    Changes in basal laser Doppler flowmetry (LDF) of skin blood flow in sickle cell disease are reported to have pathophysiologic relevance in pain crisis. This is the first study to strictly control for LDF variability in determining the value of serial, basal (unprovoked) skin LDF as a practical method to assess resolution of acute pain crisis in sickle cell patients. Daily LDF measurements were repeated on the exact same skin areas of the calf and forehead throughout each of 12 hospital admissions for uncomplicated acute pain crisis. A progressive increase in perfusion was observed in the calf throughout hospitalization as pain crisis resolved, but measurement reproducibility in the calf was poor. Reproducibility in the forehead was better, but no significant trend over time in perfusion was seen. There was no significant correlation between perfusion and pain scores over time. There was also no significant pattern of LDF oscillations over time. In conclusion, only perfusion units and not oscillatory patterns of LDF have probable pathophysiological significance in sickle cell disease vaso-occlusion. The reproducibility of basal skin LDF specifically in sickle cell disease needs to be confirmed.

  2. Schlieren laser Doppler flowmeter for the human optical nerve head with the flicker stimuli.

    PubMed

    Geiser, Martial H; Truffer, Frederic; Evequoz, Hugo; Khayi, Hafid; Mottet, Benjamin; Chiquet, Christophe

    2013-12-01

    We describe a device to measure blood perfusion for the human optic nerve head (ONH) based on laser Doppler flowmetry (LDF) with a flicker stimuli of the fovea region. This device is self-aligned for LDF measurements and includes near-infrared pupil observation, green illumination, and observation of the ONH. The optical system of the flowmeter is based on a Schlieren arrangement which collects only photons that encounter multiple scattering and are back-scattered out of the illumination point. LDF measurements are based on heterodyne detection of Doppler shifted back-scattered light. We also describe an automated analysis of the LDF signals which rejects artifacts and false signals such as blinks. By using a Doppler simulator consisting of a lens and a rotating diffusing wheel, we demonstrate that velocity and flow vary linearly with the speed of the wheel. A cohort of 12 healthy subjects demonstrated that flicker stimulation induces an increase of 17.8% of blood flow in the ONH.

  3. A multi-point laser Doppler vibrometer with fiber-based configuration.

    PubMed

    Yang, C; Guo, M; Liu, H; Yan, K; Xu, Y J; Miao, H; Fu, Y

    2013-12-01

    Laser Doppler vibrometer (LDV) is a non-contact optical interferometric system to measure vibrations of structures and machines with a high precision. Normal LDV can only offer a single-point measurement. Scanning LDV is usually impractical to do measurement on transient events. In this paper, a fiber-based self-synchronized multi-point LDV is proposed. The multiple laser beams with different frequency shifts are generated from one laser source. The beams are projected onto a vibrating object, reflected and interfered with a common reference beam. The signal including vibration information of multiple spatial points is captured by one single-pixel photodetector. The optical system is mainly integrated by fiber components for flexibility in measurement. Two experiments are conducted to measure a steady-state simple harmonic vibration of a cantilever beam and a transient vibration of a beam clamped at both ends. In the first measurement, a numerical interpolation is applied to reconstruct the mode shape with increased number of data points. The vibration mode obtained is compared with that from FEM simulation. In transient vibration measurement, the first five resonant frequencies are obtained. The results show the new-reported fiber-based multipoint LDV can offer a vibration measurement on various spatial points simultaneously. With the flexibility of fiber configuration, it becomes more practical for dynamic structural evaluation in industrial areas.

  4. In-field use of laser Doppler vibrometer on a wind turbine blade

    SciTech Connect

    Rumsey, M.; Hurtado, J.; Hansche, B.

    1998-12-31

    One of our primary goals was to determine how well a laser Doppler vibrometer (LDV) could measure the structural dynamic response of a wind turbine that was parked in the field. We performed a series of preliminary tests in the lab to determine the basic limitations of the LDV for this application. We then instrumented an installed parked horizontal axis wind turbine with accelerometers to determine the natural frequencies, damping, and mode shapes of the wind turbine and rotor as a baseline for the LDV and our other tests. We also wanted to determine if LDV modal information could be obtained from a naturally (wind) excited wind turbine. We compared concurrently obtained accelerometer and LDV data in an attempt to assess the quality of the LDV data. Our test results indicate the LDV can be successfully used in the field environment of an installed wind turbine, but with a few restrictions. We were successful in obtaining modal information from a naturally (wind) excited wind turbine in the field, but the data analysis requires a large number of averaged data sets to obtain reasonable results. An ultimate goal of this continuing project is to develop a technique that will monitor the health of a structure, detect damage, and hopefully predict an impending component failure.

  5. Directional-sensitive differential laser Doppler vibrometry for in-plane motion measurement of specular surface

    NASA Astrophysics Data System (ADS)

    Agusanto, Kusuma; Lau, Gih-Keong; Wu, Kun; Liu, Ting; Zhu, Chuangui; Yuan, Ling

    2015-03-01

    A new method for measuring in-plane vibration velocity of glossy and specular surface using differential laser Doppler vibrometer (LDV) is proposed in this work. A standard tangential LDV using similar differential configuration is only able to measure in-plane velocity of objects with rough surface, due to its inherent on-axis optical design that collects backscatter light along its optical axis. The proposed method adopts an off-axis detection scheme, in which the photodetector is decoupled from LDV, and placed along the dominant direction of the scattered light. For optimal placement, the bidirectional reflectance distribution function (BRDF) of the sample must be considered ideally, but in our measurement tests, the off-axis detection along the direction of specular reflection is sufficient to obtain good measurement results. Another advantage with this setup is that it also works with the objects with rough surface. Experimental works using the standard tangential LDV and a prototype of this method were conducted to measure the in-plane motion of four different samples representing rough, glossy and mirror-like surface. An electrodynamic shaker was used to provide the in-plane motion of the samples at three different frequencies. A single point axial vibrometer was used to validate the in-plane velocity of the measurement from both in-plane LDVs. Some preliminary results showed that the in-plane motion of the object with glossy and specular surface can be measured using the proposed method.

  6. Multi-frequency, 3D ODS measurement by continuous scan laser Doppler vibrometry

    NASA Astrophysics Data System (ADS)

    Weekes, Ben; Ewins, David

    2015-06-01

    Continuous scan laser Doppler vibrometry (CSLDV) is a technique which has been described and explored in the literature for over two decades, but remains niche compared to SLDV inspection by a series of discrete-point measurements. This is in part because of the unavoidable phenomenon of laser speckle, which deteriorates signal quality when velocity data is captured from a moving spot measurement. Further, applicability of CSLDV has typically been limited to line scans and rectangular areas by the application of sine, step, or ramp functions to the scanning mirrors which control the location of the measurement laser spot. In this paper it is shown that arbitrary functions to scan any area can easily be derived from a basic calibration routine, equivalent to the calibration performed in conventional discrete-point laser vibrometry. This is extended by performing the same scan path upon a test surface from three independent locations of the laser head, and decomposing the three sets of one-dimensional deflection shapes into a single set of three-dimensional deflection shapes. The test was performed with multi-sine excitation, yielding 34 operating deflection shapes from each scan.

  7. Agent-based station for on-line diagnostics by self-adaptive laser Doppler vibrometry.

    PubMed

    Serafini, S; Paone, N; Castellini, P

    2013-12-01

    A self-adaptive diagnostic system based on laser vibrometry is proposed for quality control of mechanical defects by vibration testing; it is developed for appliances at the end of an assembly line, but its characteristics are generally suited for testing most types of electromechanical products. It consists of a laser Doppler vibrometer, equipped with scanning mirrors and a camera, which implements self-adaptive bahaviour for optimizing the measurement. The system is conceived as a Quality Control Agent (QCA) and it is part of a Multi Agent System that supervises all the production line. The QCA behaviour is defined so to minimize measurement uncertainty during the on-line tests and to compensate target mis-positioning under guidance of a vision system. Best measurement conditions are reached by maximizing the amplitude of the optical Doppler beat signal (signal quality) and consequently minimize uncertainty. In this paper, the optimization strategy for measurement enhancement achieved by the down-hill algorithm (Nelder-Mead algorithm) and its effect on signal quality improvement is discussed. Tests on a washing machine in controlled operating conditions allow to evaluate the efficacy of the method; significant reduction of noise on vibration velocity spectra is observed. Results from on-line tests are presented, which demonstrate the potential of the system for industrial quality control.

  8. Hidden state models for noncontact measurements of the carotid pulse using a laser Doppler vibrometer.

    PubMed

    Kaplan, Alan D; O'Sullivan, Joseph A; Sirevaag, Erik J; Lai, Po-Hsiang; Rohrbaugh, John W

    2012-03-01

    The method of laser Doppler vibrometry (LDV) is used to sense movements of the skin overlying the carotid artery. When pointed at the skin overlying the carotid artery, the mechanical movements of the skin disclose physiological activity relating to the blood pressure pulse over the cardiac cycle. In this paper, signal modeling is addressed, with close attention to the underlying physiology. Segments of the LDV signal corresponding to single heartbeats, called LDV pulses, are extracted. Hidden Markov models (HMMs) are used to capture the dynamics of the LDV pulses from beat to beat based on pulse morphology; under resting conditions these dynamics are primarily due to respiration-related effects. LDV pulses are classified according to state, by computing the optimal state path through the data using trained HMMs. HMM state dynamics are examined within the context of respiratory effort using strain gauges placed around the abdomen. This study presented here provides a graphical model approach to modeling the dependence of the LDV pulse on latent states.

  9. Laser Doppler vibrometer (LDV)--a new clinical tool for the otologist.

    PubMed

    Goode, R L; Ball, G; Nishihara, S; Nakamura, K

    1996-11-01

    We describe a laser Doppler system (LDS) that can be used clinically for the measurement of tympanic membrane (TM), malleus and prosthesis head displacement in response to sound inputs of 80-to 100-dB sound-pressure level (SPL). It also has the potential for use in the operating room to perform measurements of prosthesis and stapes displacement. The information provided by such testing gives the otologist knowledge of TM and ossicular function that is unique in evaluating middle ear function; it should help select the best type of reconstruction in a given case and direct us toward new and better methods of TM and ossicular reconstruction. The results of umbo displacement measurements in 95 human ears are reported. Examples are provided of LDS measurements in representative ears and how they can be of help to the clinician. The potential of multisite TM-displacement testing is demonstrated in two temporal bones, including before and after partial ossicular replacement prosthesis (PORP) insertion.

  10. Multipoint laser Doppler vibrometry with single detector: principles, implementations, and signal analyses.

    PubMed

    Fu, Y; Guo, M; Phua, P B

    2011-04-01

    A 20-point laser Doppler vibrometer with single photodetector is presented for noncontact dynamic measurement. A 5×4 beam array with various frequency shifts is generated by a 1.55 μm distributed feedback laser and four acousto-optic devices, and illuminating different points on vibrating objects. The reflected beams are coupled into a single-mode fiber by a pigtailed collimator and interfere with a reference beam. The signal output from a high-speed photodetector is amplified and then digitized by a high-speed analog-to-digital converter with a sampling rate of 1 gigasample per second (1 GS/s). Several methods are introduced to avoid the cross talk among different frequencies and extract the vibration information of 20 points from a one-dimensional signal. Two signal processing algorithms based on Fourier transform and windowed Fourier transform are illustrated to extract the vibration signals at different points. The experimental results are compared with that from a commercial single-point laser vibrometer. The results show simultaneous vibration measurement can be realized on multiple points using a single laser source and a single photodetector.

  11. A normative study of tympanic membrane motion in humans using a laser Doppler vibrometer (LDV).

    PubMed

    Whittemore, Kenneth R; Merchant, Saumil N; Poon, Becky B; Rosowski, John J

    2004-01-01

    Laser Doppler vibrometry was used to measure the sound-induced tympanic membrane (TM) velocity, assessed near the umbo, in 56 normal hearing human subjects at nine sound frequencies. A second series of measurements was made in 47 subjects with sensorineural hearing loss (SNHL). Each set of measurements has features in common with previously published results. The measured velocity magnitude (normalized by the stimulus sound pressure) at any one frequency ranged among subjects by factors of 3-0.3 (+/-10 dB) from the mean and the phase angle of the normalized velocity ranged from +/-15 degrees around the mean at low frequencies to more than +/-200 degrees around the mean at 6 kHz. Measurements repeated after intervals of minutes to months were generally within 40% in magnitude (+/-3 dB) and 20 degrees in phase. Sources of variability included the effect of small differences in the location of the measurement on the TM and small static middle-ear pressures. No effects of stimulus level, ear sidedness (right or left), gender, age or the presence or absence of SNHL were found. These results provide a baseline normal response for studies of TM velocity with conductive hearing losses of different etiologies.

  12. Photo-vibrational spectroscopy of solid and liquid chemicals using laser Doppler vibrometer.

    PubMed

    Hu, Qi; Lim, Jacob Song Kiat; Liu, Huan; Fu, Yu

    2016-08-22

    Photoacoustic/photothermal spectroscopy is an established technique for trace detection of chemicals and explosives. However, prior sample preparation is required and the analysis is conducted in a sealed space with a high-sensitivity microphone or a piezo sensor coupled with a lock-in amplifier, limiting the technique to applications in a laboratory environment. Due to the aforementioned requirements, traditionally this technique may not be suitable for defense and security applications where the detection of explosives or hazardous chemicals is required in an open environment at a safe standoff distance. In this study, chemicals in various forms (membrane, powder and liquid) were excited by an intensity-modulated quantum cascade laser (QCL), while a laser Doppler vibrometer (LDV) based on the Mach-Zehnder interferometer was applied to detect the vibration signal resulting from the photocoustic/photothermal effect. The photo-vibrational spectrum obtained by scanning the QCL's wavelength in MIR range, coincides well with the corresponding spectrum obtained using typical FTIR equipment. The experiment demonstrated that the LDV is a capable sensor for applications in photoacoustic/photothermal spectroscopy, with potential to enable the detection of chemicals in open environment at safe standoff distance.

  13. Engine classification using vibrations measured by Laser Doppler Vibrometer on different surfaces

    NASA Astrophysics Data System (ADS)

    Wei, J.; Liu, Chi-Him; Zhu, Zhigang; Vongsy, Karmon; Mendoza-Schrock, Olga

    2015-05-01

    In our previous studies, vehicle surfaces' vibrations caused by operating engines measured by Laser Doppler Vibrometer (LDV) have been effectively exploited in order to classify vehicles of different types, e.g., vans, 2-door sedans, 4-door sedans, trucks, and buses, as well as different types of engines, such as Inline-four engines, V-6 engines, 1-axle diesel engines, and 2-axle diesel engines. The results are achieved by employing methods based on an array of machine learning classifiers such as AdaBoost, random forests, neural network, and support vector machines. To achieve effective classification performance, we seek to find a more reliable approach to pick authentic vibrations of vehicle engines from a trustworthy surface. Compared with vibrations directly taken from the uncooperative vehicle surfaces that are rigidly connected to the engines, these vibrations are much weaker in magnitudes. In this work we conducted a systematic study on different types of objects. We tested different types of engines ranging from electric shavers, electric fans, and coffee machines among different surfaces such as a white board, cement wall, and steel case to investigate the characteristics of the LDV signals of these surfaces, in both the time and spectral domains. Preliminary results in engine classification using several machine learning algorithms point to the right direction on the choice of type of object surfaces to be planted for LDV measurements.

  14. Non-contact measurement of facial surface vibration patterns during singing by scanning laser Doppler vibrometer.

    PubMed

    Kitamura, Tatsuya; Ohtani, Keisuke

    2015-01-01

    This paper presents a method of measuring the vibration patterns on facial surfaces by using a scanning laser Doppler vibrometer (LDV). The surfaces of the face, neck, and body vibrate during phonation and, according to Titze (2001), these vibrations occur when aerodynamic energy is efficiently converted into acoustic energy at the glottis. A vocalist's vibration velocity patterns may therefore indicate his or her phonatory status or singing skills. LDVs enable laser-based non-contact measurement of the vibration velocity and displacement of a certain point on a vibrating object, and scanning LDVs permit multipoint measurements. The benefits of scanning LDVs originate from the facts that they do not affect the vibrations of measured objects and that they can rapidly measure the vibration patterns across planes. A case study is presented herein to demonstrate the method of measuring vibration velocity patterns with a scanning LDV. The objective of the experiment was to measure the vibration velocity differences between the modal and falsetto registers while three professional soprano singers sang sustained vowels at four pitch frequencies. The results suggest that there is a possibility that pitch frequency are correlated with vibration velocity. However, further investigations are necessary to clarify the relationships between vibration velocity patterns and phonation status and singing skills.

  15. Broadband measurement of translational and angular vibrations using a single continuously scanning laser Doppler vibrometer.

    PubMed

    Salman, Muhammad; Sabra, Karim G

    2012-09-01

    A continuous scanning laser Doppler velocimetry (CSLDV) technique is used to measure the low frequency broadband vibrations associated with human skeletal muscle vibrations (typically f < 100 Hz) by continuously varying the orientation of laser beam over distances that are short compared to the characteristic wavelengths of the vibrations. The high frequency scan (compared to the vibration frequency) enables the detection of broadband translational and angular velocities at a single point using amplitude demodulation of the CSDLV signal. For instance, linear scans allow measurement of the normal surface velocity and one component of angular velocity vector, while circular scans allow measurement of an additional angular velocity component. This CSLDV technique is first validated here using gel samples mimicking soft tissues and then applied to measure multiple degrees of freedom (DOF) of a subject's hand exhibiting fatigue-induced tremor. Hence this CSLDV technique potentially provides a means for measuring multiple DOF of small human body parts (e.g., fingers, tendons, small muscles) for various applications (e.g., haptic technology, remote surgery) when the use of skin-mounted sensors (e.g. accelerometers) can be problematic due to mass-loading artifacts or tethering issues.

  16. Laser Doppler velocity measurements in a transferred-arc plasma torch

    SciTech Connect

    Norton, O.P.; Okhuysen, W.P.

    1995-12-31

    Laser Doppler velocimetry (LDV) is a nonintrusive method of measuring velocity. The measurement volume formed by the intersection of the two laser beams is compact, thus the method provides excellent spatial resolution. Furthermore, aside from the requirement that the flow contain scattering particles, the method is nonintrusive. Thus, no probe disturbs the flow and measurements can be made in extremely high temperature and hostile environments. Here, the LDV technique has been used to map the velocity field in the plasma jet issuing from a transferred-arc, reverse polarity plasma torch. This gas flow field is important in understanding the physics of the plasma torch. The torch was operated with nitrogen at a fixed distance of 5 inches from the graphite billet. Velocity measurements were made for combinations of current at 125 and 175 A and pressure at 22 and 55 psig. Results are presented for the high current/high pressure condition. Since the test procedure involves reestablishing the same flow conditions after swapping graphite billets, it is instructive to see how closely the torch operating variables were reproduced. The average current varied from 175.2 to 175.8 A over the eight separate time periods. The nitrogen supply pressure varied from 52.5 to 53.9 psi. The torch voltage drop ranged from 430.6 to 436.1 V, and the nitrogen flow rate from 4.8 to 5.4 scfm.

  17. Choroidal laser Doppler flowmeter with enhanced sensitivity based on a scattering plate

    NASA Astrophysics Data System (ADS)

    Wang, Chuan; Ding, Zhihua; Geiser, Martial; Wu, Tong; Chen, Minghui

    2011-04-01

    A portable choroidal laser Doppler flowmeter (LDF) with enhanced sensitivity based on a scattering plate is developed. The portable LDF is weighted 2 kg operated at center wavelength of 780 nm, leading to a better penetration into the eye fundus in contrast to the previous LDF operated at center wavelength of 670 nm. Enhancement of number of detected photons that undergo Doppler scattering and improved measured speed of choroidal blood flow are achieved with the use of a scattering plate positioned in front of the eye. The mechanism of detection and sensitivity enhancement is theoretically analyzed. Evaluation of system performance is done by in vivo measurements on ten volunteers. The results demonstrate that an increased percentage of backscattering light at high Doppler shift frequency is collected due to utilization of the scattering plate. However, this kind of light detection influences spatial resolution of the system and decreases the total signal measured. The proposed method for detection and sensitivity enhancement might be useful in a case where the perception of very slight alternation of blood flow is pursued and the spatial resolution is not as critical as that in a choroidal vascular bed.

  18. Multifractal spectra of laser Doppler flowmetry signals in healthy and sleep apnea syndrome subjects

    NASA Astrophysics Data System (ADS)

    Buard, Benjamin; Trzepizur, Wojciech; Mahe, Guillaume; Chapeau-Blondeau, François; Rousseau, David; Gagnadoux, Frédéric; Abraham, Pierre; Humeau, Anne

    2009-07-01

    Laser Doppler flowmetry (LDF) signals give a peripheral view of the cardiovascular system. To better understand the possible modifications brought by sleep apnea syndrome (SAS) in LDF signals, we herein propose to analyze the complexity of such signals in obstructive SAS subjects, and to compare the results with those obtained in healthy subjects. SAS is a pathology that leads to a drop in the parasympathetic tone associated with an increase in the sympathetic tone in awakens SAS patients. Nine men with obstructive SAS and nine healthy men participated awaken in our study and LDF signals were recorded in the forearm. In our work, complexity of LDF signals is analyzed through the computation and analysis of their multifractal spectra. The multifractal spectra are estimated by first estimating the discrete partition function of the signals, then by determining their Renyi exponents with a linear regression, and finally by computing their Legendre transform. The results show that, at rest, obstructive SAS has no or little impact on the multifractal spectra of LDF signals recorded in the forearm. This study shows that the physiological modifications brought by obstructive SAS do not modify the complexity of LDF signals when recorded in the forearm.

  19. Agent-based station for on-line diagnostics by self-adaptive laser Doppler vibrometry

    NASA Astrophysics Data System (ADS)

    Serafini, S.; Paone, N.; Castellini, P.

    2013-12-01

    A self-adaptive diagnostic system based on laser vibrometry is proposed for quality control of mechanical defects by vibration testing; it is developed for appliances at the end of an assembly line, but its characteristics are generally suited for testing most types of electromechanical products. It consists of a laser Doppler vibrometer, equipped with scanning mirrors and a camera, which implements self-adaptive bahaviour for optimizing the measurement. The system is conceived as a Quality Control Agent (QCA) and it is part of a Multi Agent System that supervises all the production line. The QCA behaviour is defined so to minimize measurement uncertainty during the on-line tests and to compensate target mis-positioning under guidance of a vision system. Best measurement conditions are reached by maximizing the amplitude of the optical Doppler beat signal (signal quality) and consequently minimize uncertainty. In this paper, the optimization strategy for measurement enhancement achieved by the down-hill algorithm (Nelder-Mead algorithm) and its effect on signal quality improvement is discussed. Tests on a washing machine in controlled operating conditions allow to evaluate the efficacy of the method; significant reduction of noise on vibration velocity spectra is observed. Results from on-line tests are presented, which demonstrate the potential of the system for industrial quality control.

  20. Microcirculation assessment using an individualized model for diffuse reflectance spectroscopy and conventional laser Doppler flowmetry

    NASA Astrophysics Data System (ADS)

    Strömberg, Tomas; Karlsson, Hanna; Fredriksson, Ingemar; Nyström, Fredrik H.; Larsson, Marcus

    2014-05-01

    Microvascular assessment would benefit from co-registration of blood flow and hemoglobin oxygenation dynamics during stimulus response tests. We used a fiber-optic probe for simultaneous recording of white light diffuse reflectance (DRS; 475-850 nm) and laser Doppler flowmetry (LDF; 780 nm) spectra at two source-detector distances (0.4 and 1.2 mm). An inverse Monte Carlo algorithm, based on a multiparameter three-layer adaptive skin model, was used for analyzing DRS data. LDF spectra were conventionally processed for perfusion. The system was evaluated on volar forearm recordings of 33 healthy subjects during a 5-min systolic occlusion protocol. The calibration scheme and the optimal adaptive skin model fitted DRS spectra at both distances within 10%. During occlusion, perfusion decreased within 5 s while oxygenation decreased slowly (mean time constant 61 s dissociation of oxygen from hemoglobin). After occlusion release, perfusion and oxygenation increased within 3 s (inflow of oxygenized blood). The increased perfusion was due to increased blood tissue fraction and speed. The supranormal hemoglobin oxygenation indicates a blood flow in excess of metabolic demands. In conclusion, by integrating DRS and LDF in a fiber-optic probe, a powerful tool for assessment of blood flow and oxygenation in the same microvascular bed has been presented.

  1. Microcirculation in healing and healthy Achilles tendon assessed with invasive laser doppler flowmetry

    PubMed Central

    Arverud, Erica Domeij; Persson-Lindell, Olof; Sundquist, Fredrik; Labruto, Fausto; Edman, Gunnar; Ackermann, Paul W.

    2016-01-01

    Summary Introduction Achilles tendon (AT) rupture exhibits a prolonged healing process with varying clinical outcome. Reduced blood flow to the AT has been considered an underlying factor to AT rupture (ATR) and impaired healing. In vivo measurements using laser Doppler flowmetry (LDF) may be a viable method to assess blood flow in healthy and healing AT. Methods 29 persons were included in the study; 9 being ATR patients and 20 healthy subjects without any prior symptoms from the AT. Invasive LDF was used to determine the post-occlusive reactive hyperemia (PORH) in the paratenon after 15 minutes of occlusion of the lower extremities. ATR patients were examined two weeks post-operatively. Results LDF-assessments demonstrated a significantly different (p < 0.001) PORH response in the healing- versus intact- and control AT. In the healing AT, a slow, flattened PORH was observed compared to a fast, high peak PORH in intact, healthy AT. Conclusion in vivo LDF appears to be a feasible method to assess alterations in blood flow in healing and intact AT. The healing ATs capability to react to an ischemic period is clearly impaired, which may be due to the trauma at injury and/or surgery or degenerative changes in the tendon. PMID:27331035

  2. Atmospheric transmission of CO2 laser radiation with application to laser Doppler systems

    NASA Technical Reports Server (NTRS)

    Murty, S. S. R.

    1975-01-01

    The molecular absorption coefficients of carbon dioxide, water vapor, and nitrous oxide are calculated at the P16, P18, P20, P22, and P24 lines of the CO2 laser for temperatures from 200 to 300 K and for pressures from 100 to 1100 mb. The temperature variation of the continuum absorption coefficient of water vapor is taken into account semi-empirically from Burch's data. The total absorption coefficient from the present calculations falls within + or - 20 percent of the results of McClatchey and Selby. The transmission loss which the CO2 pulsed laser Doppler system experiences was calculated for flight test conditions for the five P-lines. The total transmission loss is approximately 7 percent higher at the P16 line and 10 percent lower at the P24 line compared to the P20 line. Comparison of the CO2 laser with HF and DF laser transmission reveals the P2(8) line at 3.8 micrometers of the DF laser is much better from the transmission point of view for altitudes below 10 km.

  3. Full-field vibrometry with digital Fresnel holography

    SciTech Connect

    Leval, Julien; Picart, Pascal; Boileau, Jean Pierre; Pascal, Jean Claude

    2005-09-20

    A setup that permits full-field vibration amplitude and phase retrieval with digital Fresnel holography is presented. Full reconstruction of the vibration is achieved with a three-step stroboscopic holographic recording, and an extraction algorithm is proposed. The finite temporal width of the illuminating light is considered in an investigation of the distortion of the measured amplitude and phase. In particular, a theoretical analysis is proposed and compared with numerical simulations that show good agreement. Experimental results are presented for a loudspeaker under sinusoidal excitation; the mean quadratic velocity extracted from amplitude evaluation under two different measuring conditions is presented. Comparison with time averaging validates the full-field vibrometer.

  4. Inspection 13.2 nm table-top full-field microscope

    SciTech Connect

    Brizuela, F.; Wang, Y.; Brewer, C. A.; Pedaci, F.; Chao, W.; Anderson, E. H.; Liu, Y.; Goldberg, K. A.; Naulleau, P.; Wachulak, P.; Marconi, M. C.; Attwood, D. T.; Rocca, J. J.; Menoni, C. S.

    2009-02-23

    We present results on a table-top microscope that uses an EUV stepper geometry to capture full-field images with a halfpitch spatial resolution of 55 nm. This microscope uses a 13.2 nm wavelength table-top laser for illumination and acquires images of reflective masks with exposures of 20 seconds. These experiments open the path to the realization of high resolution table-top imaging systems for actinic defect characterization.

  5. STIS MAMA Full-Field Sensitivity Monitor C21

    NASA Astrophysics Data System (ADS)

    Roman-Duval, Julia

    2013-10-01

    The purpose of this program is to monitor the sensitivity of the MAMA detectors over the full field. This is achieved by observing the globular cluster NGC6681 once during Cycle 21. The data can be directly compared with similar data obtained in previous cycles.

  6. STIS MAMA Full-Field Sensitivity Monitor C18

    NASA Astrophysics Data System (ADS)

    Dixon, W.

    2010-09-01

    The purpose of this program is to monitor the sensitivity of the MAMA detectors over the full field. This is achieved by observing the globular cluster NGC6681 once during Cycle 18. The data can be directly compared with similar data obtained in Cycles 7, 8, 9, 10, 11, 12, and 17.

  7. STIS MAMA Full-Field Sensitivity Monitor C19

    NASA Astrophysics Data System (ADS)

    Roman-Duval, Julia

    2011-10-01

    The purpose of this program is to monitor the sensitivity of the MAMA detectors over the full field. This is achieved by observing the globular cluster NGC6681 once during Cycle 19. The data can be directly compared with similar data obtained in Cycles 7, 8, 9, 10, 11, 12, 17, and 18.

  8. STIS MAMA Full-Field Sensitivity Monitor C20

    NASA Astrophysics Data System (ADS)

    Roman-Duval, Julia

    2012-10-01

    The purpose of this program is to monitor the sensitivity of the MAMA detectors over the full field. This is achieved by observing the globular cluster NGC6681 once during Cycle 19. The data can be directly compared with similar data obtained in Cycles 7, 8, 9, 10, 11, 12, 17, and 18.

  9. In vivo visualization method by absolute blood flow velocity based on speckle and fringe pattern using two-beam multipoint laser Doppler velocimetry

    NASA Astrophysics Data System (ADS)

    Kyoden, Tomoaki; Naruki, Shoji; Akiguchi, Shunsuke; Ishida, Hiroki; Andoh, Tsugunobu; Takada, Yogo; Momose, Noboru; Homae, Tomotaka; Hachiga, Tadashi

    2016-08-01

    Two-beam multipoint laser Doppler velocimetry (two-beam MLDV) is a non-invasive imaging technique able to provide an image of two-dimensional blood flow and has potential for observing cancer as previously demonstrated in a mouse model. In two-beam MLDV, the blood flow velocity can be estimated from red blood cells passing through a fringe pattern generated in the skin. The fringe pattern is created at the intersection of two beams in conventional LDV and two-beam MLDV. Being able to choose the depth position is an advantage of two-beam MLDV, and the position of a blood vessel can be identified in a three-dimensional space using this technique. Initially, we observed the fringe pattern in the skin, and the undeveloped or developed speckle pattern generated in a deeper position of the skin. The validity of the absolute velocity value detected by two-beam MLDV was verified while changing the number of layers of skin around a transparent flow channel. The absolute velocity value independent of direction was detected using the developed speckle pattern, which is created by the skin construct and two beams in the flow channel. Finally, we showed the relationship between the signal intensity and the fringe pattern, undeveloped speckle, or developed speckle pattern based on the skin depth. The Doppler signals were not detected at deeper positions in the skin, which qualitatively indicates the depth limit for two-beam MLDV.

  10. Precise full-field distortion rectification and evaluation method for a digital projector

    NASA Astrophysics Data System (ADS)

    Wang, Zhangying; Liu, Miao; Yang, Shourui; Huang, Shujun; Bai, Xuefei; Liu, Xiaohong; Zhu, Jigui; Liu, Xiaoli; Zhang, Zonghua

    2016-10-01

    Digital projectors have been widely used in many accuracy-sensitive fields. Although some calibration methods have been proposed to obtain the intrinsic parameters for a digital projector, especially the radial and tangential distortion, there are few studies on how to rectify the projected image to obtain an ideal projection pattern and further evaluate the results. In this paper, a precise full-field image rectification technique is proposed based on the principle of projector calibration. The pixel remapping and interpolation techniques are detailed step by step. All of the method's steps maintain subpixel accuracy. Moreover, a full-field verification method is presented to evaluate the effectiveness of the projector distortion procedure using a full-field phase map. A full-field non-linear distortion distribution map can be generated to represent distortion characteristics of nearly all the pixels of a projector in a very intuitive way. The experimental results validate and show the effectiveness of the proposed full-field rectification technique and evaluation method.

  11. Precise full-field distortion rectification and evaluation method for a digital projector

    NASA Astrophysics Data System (ADS)

    Wang, Zhangying; Liu, Miao; Yang, Shourui; Huang, Shujun; Bai, Xuefei; Liu, Xiaohong; Zhu, Jigui; Liu, Xiaoli; Zhang, Zonghua

    2016-08-01

    Digital projectors have been widely used in many accuracy-sensitive fields. Although some calibration methods have been proposed to obtain the intrinsic parameters for a digital projector, especially the radial and tangential distortion, there are few studies on how to rectify the projected image to obtain an ideal projection pattern and further evaluate the results. In this paper, a precise full-field image rectification technique is proposed based on the principle of projector calibration. The pixel remapping and interpolation techniques are detailed step by step. All of the method's steps maintain subpixel accuracy. Moreover, a full-field verification method is presented to evaluate the effectiveness of the projector distortion procedure using a full-field phase map. A full-field non-linear distortion distribution map can be generated to represent distortion characteristics of nearly all the pixels of a projector in a very intuitive way. The experimental results validate and show the effectiveness of the proposed full-field rectification technique and evaluation method.

  12. Autonomous structural health monitoring technique for interplanetary drilling applications using laser Doppler velocimeters

    NASA Astrophysics Data System (ADS)

    Statham, Shannon M.

    The research work presented in this thesis is devoted to the formulation and field testing of a dynamics-based structural health monitoring system for an interplanetary subsurface exploration drill system. Structural health monitoring is the process of detecting damage or other types of defects in structural and mechanical systems that have the potential to adversely affect the current or future performance of these systems. Interplanetary exploration missions, specifically to Mars, involve operations to search for water and other signs of extant or past life. Such missions require advanced robotic systems that are more susceptible to structural and mechanical failures, which motivates a need for structural health monitoring techniques relevant to interplanetary exploration systems. Strict design requirements for interplanetary exploration missions create unique research problems and challenges compared with structural health monitoring procedures and techniques developed to date. These challenges include implementing sensors and devices that will not interfere with the drilling operation, producing "real-time" diagnostics of the drilling condition, and developing an automation procedure for complete autonomous operations. The first research area involves modal analysis experiments to understand the dynamic characteristics of interplanetary drill structural systems in operation. These experiments also validate the use of Laser Doppler Velocimeter sensors in real-time structural health monitoring and prove the drill motor system adequately excites the drill for dynamic measurements and modal analysis while the drill is in operation. The second research area involves the development of modal analysis procedures for rotating structures using a Chebyshev signal filter to remove harmonic component and other noise from the rotating drill signal. This filter is necessary to accurately analyze the condition of the rotating drill auger tube while in operation. The third

  13. Laser-tissue interaction with fs pulses: measurement of the recoil momentum by laser Doppler vibrometry

    NASA Astrophysics Data System (ADS)

    Sessa, Gaetano; Travaglini, Michele; Mittnacht, Dirk; Foth, Hans-Jochen

    2003-07-01

    Currently ultra short pulses with pluse duration close to 100 fs are investigated for tissue ablation to perform laser surgery in a microscopic scale without any damage to the remaining tissue. Several groups showed already that the risk of thermal damage can be avoided; however the ablated material leaves the surface with a high velocity which leads to significant recoil momentum to the tissue. This paper focuses on the experimental set-up to measure this momentum transfer. Various set-ups had been developd over the last years like a pendulum that is highly senstive but cannot ensure that in a train of pulses each pulse will impact at exactly the same spot. A sliding rod in a glass tube ensured the constant impact point but is sensitive to several environmental conditions, which are hard to control. Recently, special swing plates were designed as vibration disks. The small sample was mounted in the center of this plate and exposed by fs pulses of a TiSa laser. The beam of a laser Doppler vibrometer was focused onto the backside of the plate monitored its motion. This set-up enabled us to measure the recoil momentum. While the total momentum transfer could be well determined to Δp=6 10-3 g mm/s, the question about a mechanical damage, for example for hair cells in the inner ear is much more difficult to answer, since this depends on the time in which the ablated materials leaves the surface. Evaporation times of 40 ps would lead to serious risk ofhar cell damage.

  14. Quantitative assessment of UV-induced changes in microcirculatory flow by laser Doppler velocimetry.

    PubMed

    Drouard, V; Wilson, D R; Maibach, H I; Guy, R H

    1984-09-01

    Objective measurements of blood flow changes following UV irradiation in the skin of human volunteers have been made with the noninvasive technique of laser Doppler velocimetry (LDV). This optical procedure allowed perfusion (number of red cells X velocity) alterations in the cutaneous microcirculation to be monitored after exposure of the skin to UVA and UVB + UVC radiation. Response curves were obtained in 6 subjects following irradiation at 4 times the minimal UVB + UVC erythema dose (MED). Measurements were made on control (untreated) skin and on skin pretreated with a sunscreen lotion. It was found that: (1) the lotion vehicle had no protective effect, (2) the active sunscreen constituent (2-ethylhexylcinnamate, 5%) was significantly protective, and (3) the presence of bergapten (5-methoxypsoralen, 30 ppm) did not enhance or diminish the cinnamate protective effect. LDV measurements in 5 subjects were also taken during and subsequent to 5 daily exposures to 1 MED of UVB + UVC radiation. Control and pretreated skin sites were again studied and similar protective effects were observed. However, on subsequent reexposure of these sites to 4 MED of UVB + UVC, 14 days after the first of the 5 single MED doses, no significant change in skin blood perfusion was detected at either control or pretreated sites. In a separate series of experiments, LDV data were collected after UVA radiation exposures up to 15 J/cm2. No changes in microcirculation perfusion were detected in any of the situations considered. All LDV measurements were made with 2 instruments of slightly different design and were compared to subjective assessments of erythema performed by a single observer. The results suggest that LDV has significant potential as a means to quantify (1) UV exposures in excess of the MED and (2) the inhibition of UV-induced changes in microcirculatory flow by chemical protectants.

  15. Does tropicamide affect choroidal blood flow in humans? a laser Doppler flowmetry study

    NASA Astrophysics Data System (ADS)

    Palanisamy, Nithiyanantham; Riva, Charles E.; Rovati, Luigi; Cellini, Mauro; Gizzi, Corrado; Strobbe, Ernesto; Campos, Emilio C.

    2012-03-01

    The measurement of blood flow in the ocular fundus is of scientific and clinical interest. Investigating ocular blood flow in the choroid may be important to understand the pathogenesis of numerous ocular diseases, such as glaucoma or agerelated macular degeneration (AMD). Laser Doppler flowmetry (LDF) was applied to measure relative velocity, volume and flux of red blood cells in the tissues of human eye. Its main application lies in the possibility of assessing alterations in blood flow early in the course of diseases. The purpose of the present study was to investigate the effect of pupil dilatation with one drop of 1% tropicamide on blood flow in the foveal region of the choroid of the human fundus. The blood flow parameters were measured in 24 eyes during 30 minutes (one measurement in every 3 minutes) after the application of the drop. Since the Doppler parameters depend on the scattering geometry, which may change as the pupil dilates; an artificial pupil of 4mm in diameter was placed directly in front the eye. Following the administration of tropicamide the mean pupil diameter was increased from 3.29 mm to 8.25 mm (P<0.0001, Paired student t-test). In comparison to the baseline values, the data shows no significant increases were observed in velocity, volume, and flow with 4 mm artificial pupil (0.2%, 1.3%, 0.8% respectively) and a statistically significant increases were observed without artificial pupil (10.7%, 13.9%, 12.8% respectively) following the application of tropicamide.

  16. Vibration transmissibility on rifle shooter: A comparison between accelerometer and laser Doppler vibrometer data

    NASA Astrophysics Data System (ADS)

    Scalise, L.; Casacanditella, L.; Santolini, C.; Martarelli, M.; Tomasini, E. P.

    2014-05-01

    The transmission of mechanical vibrations from tools to human subjects is known to be potentially dangerous for the circulatory and neurological systems. It is also known that such damages are strictly depending on the intensity and the frequency range of the vibrational signals transferred to the different anatomical districts. In this paper, very high impulsive signals, generated during a shooting by a rifle, will be studied, being such signals characterised by a very high acceleration amplitude as well as high frequency range. In this paper, it will be presented an experimental setup aimed to collect experimental data relative to the transmission of the vibration signals from the rifle to the shoulder of subject during the shooting action. In particular the transmissibility of acceleration signals, as well as of the velocity signals, between the rifle stock and the subject's back shoulder will be measured using two piezoelectric accelerometers and a single point laser Doppler vibrometer (LDV). Tests have been carried out in a shooting lab where a professional shooter has conducted the experiments, using different experimental configurations: two different types of stocks and two kinds of bullets with different weights were considered. Two uniaxial accelerometers were fixed on the stock of the weapon and on the back of the shoulder of the shooter respectively. Vibration from the back shoulder was also measured by means of a LDV simultaneously. A comparison of the measured results will be presented and the pros and cons of the use of contact and non-contact transducers will be discussed taking into account the possible sources of the measurement uncertainty as unwanted sensor vibrations for the accelerometer.

  17. Methodology for Intraoperative Laser Doppler Vibrometry Measurements of Ossicular Chain Reconstruction

    PubMed Central

    Sokołowski, Jacek; Lachowska, Magdalena; Bartoszewicz, Robert; Niemczyk, Kazimierz

    2016-01-01

    Objectives Despite the increasing number of research concerning the applications of the Laser Doppler Vibrometry (LDV) in medicine, its usefulness is still under discussion. The aim of this study is to present a methodology developed in our Department for the LDV intraoperative assessment of ossicular chain reconstruction. Methods Ten patients who underwent “second look” tympanoplasty were involved in the study. The measurements of the acoustic conductivity of the middle ear were performed using the LDV system. Tone bursts with carrier frequencies of 500, 1,000, 2,000, and 4,000 Hz set in motion the ossicular chain. The study was divided into four experiments that examined the intra- and interindividual reproducibility, the utility of the posterior tympanotomy, the impact of changes in the laser beam angle, and the influence of reflective tape presence on measurements. Results There were no statistically significant differences between the two measurements performed in the same patient. However, interindividual differences were significant. In all cases, posterior tympanotomy proved to be useful for LDV measurements of the ossicular prosthesis vibrations. In most cases, changing the laser beam angle decreased signal amplitude about 1.5% (not significant change). The reflective tape was necessary to achieve adequate reflection of the laser beam. Conclusion LDV showed to be a valuable noncontact intraoperative tool for measurements of the middle ear conductive system mobility with a very good intraindividual repeatability. Neither a small change in the angle of the laser beam nor performing the measurements through posterior tympanotomy showed a significant influence on the results. Reflective tape was necessary to obtain good quality responses in LDV measurements. PMID:27090282

  18. Application of a laser Doppler vibrometer for air-water to subsurface signature detection

    NASA Astrophysics Data System (ADS)

    Land, Phillip; Roeder, James; Robinson, Dennis; Majumdar, Arun

    2015-05-01

    There is much interest in detecting a target and optical communications from an airborne platform to a platform submerged under water. Accurate detection and communications between underwater and aerial platforms would increase the capabilities of surface, subsurface, and air, manned and unmanned vehicles engaged in oversea and undersea activities. The technique introduced in this paper involves a Laser Doppler Vibrometer (LDV) for acousto-optic sensing for detecting acoustic information propagated towards the water surface from a submerged platform inside a 12 gallon water tank. The LDV probes and penetrates the water surface from an aerial platform to detect air-water surface interface vibrations caused by an amplifier to a speaker generating a signal generated from underneath the water surface (varied water depth from 1" to 8"), ranging between 50Hz to 5kHz. As a comparison tool, a hydrophone was used simultaneously inside the water tank for recording the acoustic signature of the signal generated between 50Hz to 5kHz. For a signal generated by a submerged platform, the LDV can detect the signal. The LDV detects the signal via surface perturbations caused by the impinging acoustic pressure field; proving a technique of transmitting/sending information/messages from a submerged platform acoustically to the surface of the water and optically receiving the information/message using the LDV, via the Doppler Effect, allowing the LDV to become a high sensitivity optical-acoustic device. The technique developed has much potential usage in commercial oceanography applications. The present work is focused on the reception of acoustic information from an object located underwater.

  19. Response measurement by laser Doppler vibrometry in vibration qualification tests with non-Gaussian random excitation

    NASA Astrophysics Data System (ADS)

    Troncossi, M.; Di Sante, R.; Rivola, A.

    2016-10-01

    In the field of vibration qualification testing, random excitations are typically imposed on the tested system in terms of a power spectral density (PSD) profile. This is the one of the most popular ways to control the shaker or slip table for durability tests. However, these excitations (and the corresponding system responses) exhibit a Gaussian probability distribution, whereas not all real-life excitations are Gaussian, causing the response to be also non-Gaussian. In order to introduce non-Gaussian peaks, a further parameter, i.e., kurtosis, has to be controlled in addition to the PSD. However, depending on the specimen behaviour and input signal characteristics, the use of non-Gaussian excitations with high kurtosis and a given PSD does not automatically imply a non-Gaussian stress response. For an experimental investigation of these coupled features, suitable measurement methods need to be developed in order to estimate the stress amplitude response at critical failure locations and consequently evaluate the input signals most representative for real-life, non-Gaussian excitations. In this paper, a simple test rig with a notched cantilevered specimen was developed to measure the response and examine the kurtosis values in the case of stationary Gaussian, stationary non-Gaussian, and burst non-Gaussian excitation signals. The laser Doppler vibrometry technique was used in this type of test for the first time, in order to estimate the specimen stress amplitude response as proportional to the differential displacement measured at the notch section ends. A method based on the use of measurements using accelerometers to correct for the occasional signal dropouts occurring during the experiment is described. The results demonstrate the ability of the test procedure to evaluate the output signal features and therefore to select the most appropriate input signal for the fatigue test.

  20. Non-invasive technique for assessment of vascular wall stiffness using laser Doppler vibrometry

    NASA Astrophysics Data System (ADS)

    Campo, Adriaan; Segers, Patrick; Heuten, Hilde; Goovaerts, Inge; Ennekens, Guy; Vrints, Christiaan; Baets, Roel; Dirckx, Joris

    2014-06-01

    It has been shown that in cardiovascular risk management, stiffness of large arteries has a very good predictive value for cardiovascular disease and mortality. This parameter is best known when estimated from the pulse wave velocity (PWV) measured between the common carotid artery (CCA) in the neck and femoral artery in the groin, but may also be determined locally from short-distance measurements on a short vessel segment. In this work, we propose a novel, non-invasive, non-contact laser Doppler vibrometry (LDV) technique for evaluating PWV locally in an elastic vessel. First, the method was evaluated in a phantom setup using LDV and a reference method. Values correlated significantly between methods (R ≤ 0.973 (p ≤ 0.01)); and a Bland-Altman analysis indicated that the mean bias was reasonably small (mean bias ≤ -2.33 ms). Additionally, PWV was measured locally on the skin surface of the CCA in 14 young healthy volunteers. As a preliminary validation, PWV measured on two locations along the same artery was compared. Local PWV was found to be between 3 and 20 m s-1, which is in line with the literature (PWV = 5-13 m s-1). PWV assessed on two different locations on the same artery correlated significantly (R = 0.684 (p < 0.01)). In summary, we conclude that this new non-contact method is a promising technique to measure local vascular stiffness in a fully non-invasive way, providing new opportunities for clinical diagnosing.

  1. A performance study of a laser Doppler vibrometer for measuring waveforms from piezoelectric transducers.

    PubMed

    Fukushima, Yo; Nishizawa, Osamu; Sato, Haruo

    2009-07-01

    The stresses at transducer contacts were estimated from accurate particle velocity measurements by using a laser Doppler vibrometer (LDV). We then evaluated the performance of LDV for ultrasonic waveform measurements in physical model experiments that are employed for modeling seismic observations. For such experiments, the characteristics of the source and detector should be exactly known. Disc-shaped compression and shear-mode piezoelectric transducers were attached on a flat surface of a steel semicircular column, and ultrasonic waves were excited by single-shot sine waves with 0.25, 0.5, and 1 MHz frequencies. Radial and transverse components were measured by LDV at a distance of 150 mm from the source. The maximum amplitudes of waves with respect to radiation angle give a radiation pattern of a transducer. Each observed radiation pattern was fitted to the calculated radiation pattern by assuming a harmonically oscillating stress distributed uniformly on a flat circular area. The observed radiation patterns show fairly good agreement with the calculated radiation patterns for both radial and transverse components when the source frequencies are 0.25 and 0.5 MHz. Because the best-fit stress values were independently estimated from the radial and the transverse radiation patterns, the 2 stress values should be equal for each source and frequency. The discrepancy between the estimated radial and transverse stress values becomes larger as the source frequency increases. Provided that coincidence of the 2 stress values indicates the validity of waveform measurements, the results suggest that LDV is applicable for measuring the 3-D particle-velocity at frequencies up to 0.5 MHz.

  2. [Intraoperative assessment by laser-Doppler skin blood flowmetry of the efficacy of endoscopic thoracic sympathectomy].

    PubMed

    Sano, T; Fukushige, T; Miyagawa, Y; Yamada, S; Kano, T

    1999-05-01

    We have investigated whether laser-Doppler (L-D) skin blood flowmetry on the finger could be useful for an intraoperative assessment of the efficacy of endoscopic thoracic sympathectomy (ETS) under general anesthesia. Subjects were 5 young adults receiving ETS for palmar hyperhidrosis. ETS was performed with the patients in the semi-sitting position under one lung ventilation. A pair of LDF probes were placed on the palmar side of the both second fingers. Palmar hyperhidrosis disappeared after ETS in all cases, but compensatory hyperhidrosis developed in the back of the body and the thigh. After completion of ETS on one side, the L-D skin blood flow increased to 267.6 +/- 211.1% on the side of ETS, and it increased in 2 other cases and decreased on the contrary in 3 cases on the other side. After ETS on both sides the L-D skin blood flow increased to 265.0 +/- 185.9% on the side of initial ETS and to 211.4 +/- 172.8% on the side of subsequent ETS. The initial EST induced reflex vasoconstriction on the finger of both sides and also on the toe. Spontaneous fluctuation and reflex vasoconstriction of the skin blood flow were still observed, although the periodicity of spontaneous fluctuation between the right and the left finger was lost in some of the cases. An increase in L-D skin blood flow on the side of ongoing ETS is useful for intraoperative assessment of ETS. PMID:10380502

  3. Full-field spatially incoherent illumination interferometry: a spatial resolution almost insensitive to aberrations

    NASA Astrophysics Data System (ADS)

    Xiao, Peng; Fink, Mathias; Boccara, A. Claude

    2016-09-01

    We show that with spatially incoherent illumination, the point spread function width of an imaging interferometer like that used in full-field optical coherence tomography (FFOCT) is almost insensitive to aberrations that mostly induce a reduction of the signal level without broadening. This is demonstrated by comparison with traditional scanning OCT and wide-field OCT with spatially coherent illuminations. Theoretical analysis, numerical calculation as well as experimental results are provided to show this specific merit of incoherent illumination in full-field OCT. To the best of our knowledge, this is the first time that such result has been demonstrated.

  4. Halo suppression in full-field x-ray Zernike phase contrast microscopy.

    PubMed

    Vartiainen, Ismo; Mokso, Rajmund; Stampanoni, Marco; David, Christian

    2014-03-15

    Visible light Zernike phase contrast (ZPC) microscopy is a well established method for imaging weakly absorbing samples. The method is also used with hard x-ray photon energies for structural evaluation of material science and biological applications. However, the method suffers from artifacts that are inherent for the Zernike image formation. In this Letter, we investigate their origin and experimentally show how to suppress them in x-ray full-field ZPC microscopy based on diffractive x-ray optics.

  5. The Use Of Full-Field XRF For Simultaneous Elemental Mapping

    SciTech Connect

    Alfeld, M.; Janssens, K.; Sasov, A.; Liu, X.; Kostenko, A.; Rickers-Appel, K.; Falkenberg, G.

    2010-04-06

    The characteristics of a Full-Field X-ray Fluorescence (FF-XRF) set-up for element-specific imaging, installed at the HASYLAB synchrotron radiation source, were determined. A lateral resolution of 10 {mu}m and limits of detection in the percentage range were found. Further potential developments in CCDs available for FF-XRF are discussed and the use of polycapillary lenses as image transfer optics is illustrated in some explorative experiments.

  6. Integration of a laser doppler vibrometer and adaptive optics system for acoustic-optical detection in the presence of random water wave distortions

    NASA Astrophysics Data System (ADS)

    Land, Phillip; Robinson, Dennis; Roeder, James; Cook, Dean; Majumdar, Arun K.

    2016-05-01

    A new technique has been developed for improving the Signal-to-Noise Ratio (SNR) of underwater acoustic signals measured above the water's surface. This technique uses a Laser Doppler Vibrometer (LDV) and an Adaptive Optics (AO) system (consisting of a fast steering mirror, deformable mirror, and Shack-Hartmann Wavefront Sensor) for mitigating the effect of surface water distortions encountered while remotely recording underwater acoustic signals. The LDV is used to perform non-contact vibration measurements of a surface via a two beam laser interferometer. We have demonstrated the feasibility of this technique to overcome water distortions artificially generated on the surface of the water in a laboratory tank. In this setup, the LDV beam penetrates the surface of the water and travels down to be reflected off a submerged acoustic transducer. The reflected or returned beam is then recorded by the LDV as a vibration wave measurement. The LDV extracts the acoustic wave information while the AO mitigates the water surface distortions, increasing the overall SNR. The AO system records the Strehl ratio, which is a measure of the quality of optical image formation. In a perfect optical system the Strehl ratio is unity, however realistic systems with imperfections have Strehl ratios below one. The operation of the AO control system in open-loop and closed-loop configurations demonstrates the utility of the AO-based LDV for many applications.

  7. Time of correlation of low-frequency fluctuations in the regional laser Doppler flow signal from human skin

    NASA Astrophysics Data System (ADS)

    Folgosi-Correa, M. S.; Nogueira, G. E. C.

    2012-06-01

    The laser Doppler flowmetry allows the non-invasive assessment of the skin perfusion in real-time, being an attractive technique to study the human microcirculation in clinical settings. Low-frequency oscillations in the laser Doppler blood flow signal from the skin have been related to the endothelial, endothelial-metabolic, neurogenic and myogenic mechanisms of microvascular flow control, in the range 0.005-0.0095 Hz, 0.0095-0.021 Hz, 0.021-0.052 Hz and 0.052- 0.145 Hz respectively. The mean Amplitude (A) of the periodic fluctuations in the laser Doppler blood flow signal, in each frequency range, derived from the respective wavelet-transformed coefficients, has been used to assess the function and dysfunctions of each mechanism of flow control. Known sources of flow signal variances include spatial and temporal variability, diminishing the discriminatory capability of the technique. Here a new time domain method of analysis is proposed, based on the Time of Correlation (TC) of flow fluctuations between two adjacent sites. Registers of blood flow from two adjacent regions, for skin temperature at 32 0C (basal) and thermally stimulated (42 0C) of volar forearms from 20 healthy volunteers were collected and analyzed. The results obtained revealed high time of correlation between two adjacent regions when thermally stimulated, for signals in the endothelial, endothelial-metabolic, neurogenic and myogenic frequency ranges. Experimental data also indicate lower variability for TC when compared to A, when thermally stimulated, suggesting a new promising parameter for assessment of the microvascular flow control.

  8. Three-channel three-dimensional self-mixing thin-slice solid-state laser-Doppler measurements

    SciTech Connect

    Ohtomo, Takayuki; Sudo, Seiichi; Otsuka, Kenju

    2009-01-20

    We report successful real-time three-channel self-mixing laser-Doppler measurements with extreme optical sensitivity using a laser-diode-pumped thin-slice Nd:GdVO4 laser in the carrier-frequency-division-multiplexing scheme with three pairs of acoustic optical modulators (i.e., frequency shifters) and a three-channel FM-wave demodulation circuit. We demonstrate (1) simultaneous independent measurement of three different nanometer-vibrating targets, (2) simultaneous measurements of small particles in Brownian motion from three directions, and (3) identification of the velocity vector of small particles moving in water flowing in a small-diameter glass pipe.

  9. Velocity surveys in a turbine stator annular-cascade facility using laser Doppler techniques. [flow measurement and flow characteristics

    NASA Technical Reports Server (NTRS)

    Goldman, L. J.; Seasholtz, R. G.; Mclallin, K. L.

    1976-01-01

    A laser Doppler velocimeter (LDV) was used to determine the flow conditions downstream of an annular cascade of stator blades operating at an exit critical velocity ratio of 0.87. Two modes of LDV operation (continuous scan and discrete point) were investigated. Conventional pressure probe measurements were also made for comparison with the LDV results. Biasing errors that occur in the LDV measurement of velocity components were also studied. In addition, the effect of pressure probe blockage on the flow conditions was determined with the LDV. Photographs and descriptions of the test equipment used are given.

  10. Evaluation of a dual beam laser Doppler displacement meter retrofitted to a coordinate measuring machine. Final report

    SciTech Connect

    Ramsdale, S.J.; Hanshaw, R.A.

    1997-05-01

    A dual beam laser Doppler displacement measuring system was mounted to a fixed-table, cantilever-type coordinate measuring machine (CMM) to establish the feasibility of real time angular error correction for each CMM axis. The performance improvement was evaluated relative to the CMM`s standard scales. The dual beam system proved to have no advantage over a single beam laser due to an inability to measure the actual angular errors at the probe location, but showed potential for substantial accuracy improvement over the standard CMM scales when geometry errors were software corrected.

  11. Wearable blood flowmeter appcessory with low-power laser Doppler signal processing for daily-life healthcare monitoring.

    PubMed

    Kuwabara, K; Higuchi, Y; Ogasawara, T; Koizumi, H; Haga, T

    2014-01-01

    A new appcessory for monitoring peripheral blood flow in daily life consists of a wearable laser Doppler sensor device and a cooperating smart phone application. Bluetooth Low Energy connects them wirelessly. The sensor device features ultralight weight of 15 g and an intermittent signal processing technique that reduces power consumption to only 7 mW at measurement intervals of 0.1 s. These features enable more than 24-h continuous monitoring of peripheral blood flow in daily life, which can provide valuable vital-sign information for healthcare services.

  12. Wearable blood flowmeter appcessory with low-power laser Doppler signal processing for daily-life healthcare monitoring.

    PubMed

    Kuwabara, K; Higuchi, Y; Ogasawara, T; Koizumi, H; Haga, T

    2014-01-01

    A new appcessory for monitoring peripheral blood flow in daily life consists of a wearable laser Doppler sensor device and a cooperating smart phone application. Bluetooth Low Energy connects them wirelessly. The sensor device features ultralight weight of 15 g and an intermittent signal processing technique that reduces power consumption to only 7 mW at measurement intervals of 0.1 s. These features enable more than 24-h continuous monitoring of peripheral blood flow in daily life, which can provide valuable vital-sign information for healthcare services. PMID:25571431

  13. Non-mechanical scanning laser Doppler velocimetry with sensitivity to direction of transverse velocity component using optical serrodyne frequency shifting

    NASA Astrophysics Data System (ADS)

    Maru, Koichi; Watanabe, Kento

    2014-05-01

    This paper proposes a non-mechanical axial scanning laser Doppler velocimeter (LDV) with sensitivity to the direction of the transverse velocity component using optical serrodyne frequency shifting. Serrodyne modulation via the electro-optic effect of a LiNbO3 (LN) phase shifter is employed to discriminate the direction of the transverse velocity component. The measurement position is scanned without any moving mechanism in the probe by changing the wavelength of the light input to the probe. The experimental results using a sensor probe setup indicate that both the scan of the measurement position and the introduction of directional sensitivity are successfully demonstrated.

  14. Full-field laser vibration measurement in NDT techniques

    NASA Astrophysics Data System (ADS)

    Yue, Kaiduan; Li, Zhongke; Yi, Yaxing; Zhang, Fei

    2008-12-01

    Research of Non Destructive Testing (NDT) methodology has developed rapidly in recent years[1][2]. But it is rarely used for small objects such as Micro-electronic Mechanics System. Due to the small size of the MEMS, the traditional method of contact measurement seriously affects the parameter of the object measured. So a high accuracy non-contact measurement is required for optimization of MEMS designs and improvement of its reliability[3][4]. With recent advances in photonics, electronics, and computer technology, a Non Destructive Testing (NDT) laser time average interferometry is proposed in the paper. Laser interferometry has the advantages of non-contact, high accuracy, full-field and fast speed, so it can be used to detect cracks in MEMS. A time average measurement method of digital speckle pattern interferometry is proposed to measure the vibration mode of the MEMS in the paper. According to the sudden change of amplitude of vibration mode, a crack can be measured. With the speckle average technology, high accuracy phase-shift, continuous phase scanning technology, combined with optical amplification technology, the resolution of the amplitude reaches 1nm, and the resolution of the crack reaches 5μm. The measurement system being full-field, the measuring speed of the measurement system can reach 512*512 points per one minute.

  15. Decoding carotid pressure waveforms recorded by laser Doppler vibrometry: Effects of rebreathing

    NASA Astrophysics Data System (ADS)

    Casaccia, Sara; Sirevaag, Erik J.; Richter, Edward; O'Sullivan, Joseph A.; Scalise, Lorenzo; Rohrbaugh, John W.

    2014-05-01

    The principal goal of this study was to assess the capability of the laser Doppler vibrometry (LDV) method for assessing cardiovascular activity. A rebreathing task was used to provoke changes within individuals in cardiac and vascular performance. The rebreathing task is known to produce multiple effects, associated with changes in autonomic drive as well as alterations in blood gases. The rise in CO2 (hypercapnia), in particular, produces changes in the cerebral and systemic circulation. The results from a rebreathing task (involving rebreathing the same air in a rubber bag) are presented for 35 individuals. The LDV pulse was measured from a site overlying the carotid artery. For comparison and validation purposes, several conventional measures of cardiovascular function were also obtained, with an emphasis on the electrocardiogram (ECG), continuous blood pressure (BP) from the radial artery, and measures of myocardial performance using impedance cardiography (ICG). During periods of active rebreathing, ventilation increased. The conventional cardiovascular effects included increased mean arterial BP and systemic vascular resistance, and decreased cardiac stroke volume (SV) and pulse transit time (PTT). These effects were consistent with a pattern of α-adrenergic stimulation. During the immediate post-rebreathing segments, in contrast, mean BP was largely unaffected but pulse BP increased, as did PTT and SV, whereas systemic vascular resistance decreased-a pattern consistent with β-adrenergic effects in combination with the direct effects of hypercapnia on the vascular system. Measures of cardiovascular activity derived from the LDV pulse velocity and displacement waveforms revealed patterns of changes that mirrored the results obtained using conventional measures. In particular, the ratio of the maximum early peak in the LDV velocity pulse to the maximum amplitude of the LDV displacement pulse (in an early systolic interval) closely mirrored the conventional

  16. Assessment of speed distribution of red blood cells in the microvascular network in healthy volunteers and type 1 diabetes using laser Doppler spectra decomposition.

    PubMed

    Wojtkiewicz, S; Wojcik-Sosnowska, E; Jasik, M; Maniewski, R; Karnafel, W; Liebert, A

    2014-02-01

    We applied a recently reported method of decomposition of laser Doppler power density spectra for in vivo monitoring of speed distributions of red blood cells (RBCs) in the microvascular network. The spectrum decomposition technique allows us to derive the distribution of RBC speed (in absolute units (mm s(-1))) versus RBC concentration (in arbitrary units). We carried out postocclusive reactive hyperaemia (PORH) test in 15 healthy volunteers and 21 diabetic patients in which the duration of type 1 diabetes was longer than 10 years. Measurements were carried out simultaneously with the use of a typical laser Doppler commercial instrument and speed resolved laser Doppler instrument utilizing the new technique based on decomposition of the laser Doppler spectra. We show that for the classical laser Doppler instrument, none of the PORH parameters revealed a statistical significance of difference between the groups analyzed. In contrast, the RBC speed distributions obtained from laser Doppler spectra during rest in the control group and type 1 diabetes are statistically significant. This result suggests that speed distribution measurements in the rest state (without any kind of stimulation test) allows for the assessment of microcirculation disorders. Measurements carried out in healthy subjects show that the first moment of speed distributions (mean speed of the distributions) is 2.32 ± 0.54 mm s(-1) and 2.57 ± 0.41 mm s(-1) for optodes located on the toe and finger of the hand, respectively. Respective values in type 1 diabetes were higher: 3.00 ± 0.36 mm s(-1) and 3.10 ± 0.48 mm s(-1).

  17. Noninvasive Measure of Microvascular Nitric Oxide Function in Humans Using Very Low-Frequency Cutaneous Laser Doppler Flow Spectra

    PubMed Central

    STEWART, JULIAN M.; TANEJA, INDU; GOLIGORSKY, MICHAEL S.; MEDOW, MARVIN S.

    2015-01-01

    Objective While higher frequency oscillations (0.021–0.6 Hz) in cutaneous blood flow measured by laser Doppler flowmetry (LDF) relate to oscillations in blood pressure and sympathetic nerve activity, very low-frequency oscillations (VLF, 0.0095–0.021 Hz) do not. The authors investigated whether VLF LDF power is nitric oxide (NO) specific. Methods LDF combined with intradermal microdialysis was used in the calves of 22 healthy volunteers aged 19–27 years. LDF power spectral analysis was performed by windowed fast Fourier transform. The authors tested whether the NO synthesis inhibitor nitro-l-arginine (NLA) produced selective decreases in VLF power before and after stimulation with acetylcholine. Results NLA alone did not alter total power but selectively reduced VLF power by approximately 50%. LDF and spectral power increased markedly across all spectra with acetylcholine. This increase was blunted by NLA, which selectively reduced VLF power by approximately 50%. Conclusions The data suggest that VLF oscillations in the laser Doppler signal are NO dependent, increase with cholinergic stimulation, and have potential as a noninvasive marker for NO-dependent microvascular reactivity. PMID:17454670

  18. Microsurgical laser Doppler probe for simultaneous intraoperative monitoring of cochlear blood flow and electrocochleography from the round window

    NASA Astrophysics Data System (ADS)

    Abiy, Lidet; Telischi, Fred; Parel, Jean-Marie A.; Manns, Fabrice; Saettele, Ralph; Morawski, Krzysztof; Ozdamar, Ozcan; Borgos, John; Delgado, Rafael; Miskiel, Edward; Yavuz, Erdem

    2003-06-01

    The aim of this project is the development of a microsurgical laser Doppler (LD) probe that simultaneously monitors blood flow and Electrocochleography (ECochG) from the round window of the ear. The device will prevent neurosensory hearing loss during acoustic neuroma surgery by preventing damage to the internal auditory nerve and to the cochlear blood flow supply. A commercially available 0.5 mm diameter Laser-Doppler velocimetry probe (LaserFlo, Vasamedics) was modified to integrate an ECochG electrode. A tube for suction and irrigation was incorporated into a sheath of the probe shaft, to facilitate cleaning of the round window (RW) and allow drug delivery to the round window membrane. The prototype microprobe was calibrated on a single vessel model and tested in vivo in a rabbit model. Preliminary results indicate that the microprobe was able to measure changes in cochlear blood flow (CBF) and ECochG potentials from the round window of rabbits in vivo. The microprobe is suitable for monitoring cochlear blood flow and auditory cochlear potentials during human surgery.

  19. [The value of laser Doppler examination of differential diagnosis of the Sudeck syndrome with local osteoporosis after tibia fracture].

    PubMed

    Grys, Grzegorz; Orłowski, Jan; Pomianowski, Stanisław; Sawicki, Grzegorz

    2003-01-01

    The fractures of the shaft of the tibia were analyzed in 120 cases. The level of the osteoporosis in the radiological examination was assessed in comparison to the healthy limb. Osteoporosis was recorded in 60.6% of the cases. The clinical symptoms of the Sudeck syndrome was recorded in 11.25% of the cases. The Laser-Doppler examination was carried out in 120 cases. A standard 3 points measurement was employed: the apex of the toe, the flexion-dorsal part of the foot, and the medial part of the mid tibia length. The examination was done comparatively on both limbs. The pressure used in the occlusion, was 100 mm Hg higher than the pressure on the humeral artery. A faster and higher amplitude post-occlusion circulation reaction in the affected limb, among the patients with an early stage of the clinically diagnosed Sudeck syndrome had been recorded. The outcome is significant statistically. The Laser-Doppler measurement of the microcirculation is a new method and definite conclusions must be draw with caution. However, these results encourage further research. PMID:15052726

  20. Continuous-scanning laser Doppler vibrometry: Extensions to arbitrary areas, multi-frequency and 3D capture

    SciTech Connect

    Weekes, B.; Ewins, D.; Acciavatti, F.

    2014-05-27

    To date, differing implementations of continuous scan laser Doppler vibrometry have been demonstrated by various academic institutions, but since the scan paths were defined using step or sine functions from function generators, the paths were typically limited to 1D line scans or 2D areas such as raster paths or Lissajous trajectories. The excitation was previously often limited to a single frequency due to the specific signal processing performed to convert the scan data into an ODS. In this paper, a configuration of continuous-scan laser Doppler vibrometry is demonstrated which permits scanning of arbitrary areas, with the benefit of allowing multi-frequency/broadband excitation. Various means of generating scan paths to inspect arbitrary areas are discussed and demonstrated. Further, full 3D vibration capture is demonstrated by the addition of a range-finding facility to the described configuration, and iteratively relocating a single scanning laser head. Here, the range-finding facility was provided by a Microsoft Kinect, an inexpensive piece of consumer electronics.

  1. New applications of scanning laser Doppler vibrometry (SLDV) to nondestructive diagnosis of artwork: mosaics, ceramics, inlaid wood, and easel painting

    NASA Astrophysics Data System (ADS)

    Castellini, Paolo; Esposito, Enrico; Marchetti, Barbara; Paone, Nicola; Tomasini, Enrico P.

    2001-10-01

    During the last years the growing importance of the correct determination of the state of conservation of artworks has been stated by all personalities in care of Cultural Heritage. There exist many analytical methodologies and techniques to individuate the physical and chemical characteristics of artworks, but at present their structural diagnostics mainly rely on the expertise of the restorer and the typical diagnostic process is accomplished mainly through manual and visual inspection of the object surface. The basic idea behind the proposed technique is to substitute human senses with measurement instruments: surfaces are very slightly vibrated by mechanical actuators, while a laser Doppler vibrometer scans the objects measuring surface velocity and producing 2D or 3D maps. Where a defect occurs velocity is higher than neighboring areas so defects can be easily spotted. Laser vibrometers also identify structural resonance frequencies thus leading to a complete characterization of defects. This work will present the most recent results coming out of the application of Scanning Laser Doppler Vibrometers (SLDV) to different types of artworks: mosaics, ceramics, inlaid wood and easel painting. Real artworks and samples realized on purpose have been studied using the proposed technique and different measuring issues resulting from each artwork category will be described.

  2. Utilization of laser Doppler flowmetry and tissue spectrophotometry for burn depth assessment using a miniature swine model.

    PubMed

    Lotter, Oliver; Held, Manuel; Schiefer, Jennifer; Werner, Ole; Medved, Fabian; Schaller, Hans-Eberhard; Rahmanian-Schwarz, Afshin; Jaminet, Patrick; Rothenberger, Jens

    2015-01-01

    Currently, the diagnosis of burn depth is primarily based on a visual assessment and can be dependent on the surgeons' experience. The goal of this study was to determine the ability of laser Doppler flowmeter combined with a tissue spectrophotometer to discriminate burn depth in a miniature swine burn model. Burn injuries of varying depth, including superficial-partial, deep-partial, and full thickness, were created in seven Göttingen minipigs using an aluminium bar (100 °C), which was applied to the abdominal skin for periods of 1, 3, 6, 12, 30, and 60 seconds with gravity alone. The depth of injury was evaluated histologically using hematoxylin and eosin staining. All burns were assessed 3 hours after injury using a device that combines a laser light and a white light to determine blood flow, hemoglobin oxygenation, and relative amount of hemoglobin. The blood flow (41 vs. 124 arbitrary units [AU]) and relative amount of hemoglobin (32 vs. 52 AU) were significantly lower in full thickness compared with superficial-partial thickness burns. However, no significant differences in hemoglobin oxygenation were observed between these depths of burns (61 vs. 60%). These results show the ability of laser Doppler flowmeter and tissue spectrophotometer in combination to discriminate between various depths of injury in the minipig model, suggesting that this device may offer a valuable tool for burn depth assessment influencing burn management.

  3. Continuous-scanning laser Doppler vibrometry: Extensions to arbitrary areas, multi-frequency and 3D capture

    NASA Astrophysics Data System (ADS)

    Weekes, B.; Ewins, D.; Acciavatti, F.

    2014-05-01

    To date, differing implementations of continuous scan laser Doppler vibrometry have been demonstrated by various academic institutions, but since the scan paths were defined using step or sine functions from function generators, the paths were typically limited to 1D line scans or 2D areas such as raster paths or Lissajous trajectories. The excitation was previously often limited to a single frequency due to the specific signal processing performed to convert the scan data into an ODS. In this paper, a configuration of continuous-scan laser Doppler vibrometry is demonstrated which permits scanning of arbitrary areas, with the benefit of allowing multi-frequency/broadband excitation. Various means of generating scan paths to inspect arbitrary areas are discussed and demonstrated. Further, full 3D vibration capture is demonstrated by the addition of a range-finding facility to the described configuration, and iteratively relocating a single scanning laser head. Here, the range-finding facility was provided by a Microsoft Kinect, an inexpensive piece of consumer electronics.

  4. Vibrational spectra of nanowires measured using laser doppler vibrometry and STM studies of epitaxial graphene : an LDRD fellowship report.

    SciTech Connect

    Biedermann, Laura Butler

    2009-09-01

    A few of the many applications for nanowires are high-aspect ratio conductive atomic force microscope (AFM) cantilever tips, force and mass sensors, and high-frequency resonators. Reliable estimates for the elastic modulus of nanowires and the quality factor of their oscillations are of interest to help enable these applications. Furthermore, a real-time, non-destructive technique to measure the vibrational spectra of nanowires will help enable sensor applications based on nanowires and the use of nanowires as AFM cantilevers (rather than as tips for AFM cantilevers). Laser Doppler vibrometry is used to measure the vibration spectra of individual cantilevered nanowires, specifically multiwalled carbon nanotubes (MWNTs) and silver gallium nanoneedles. Since the entire vibration spectrum is measured with high frequency resolution (100 Hz for a 10 MHz frequency scan), the resonant frequencies and quality factors of the nanowires are accurately determined. Using Euler-Bernoulli beam theory, the elastic modulus and spring constant can be calculated from the resonance frequencies of the oscillation spectrum and the dimensions of the nanowires, which are obtained from parallel SEM studies. Because the diameters of the nanowires studied are smaller than the wavelength of the vibrometer's laser, Mie scattering is used to estimate the lower diameter limit for nanowires whose vibration can be measured in this way. The techniques developed in this thesis can be used to measure the vibrational spectra of any suspended nanowire with high frequency resolution Two different nanowires were measured - MWNTs and Ag{sub 2}Ga nanoneedles. Measurements of the thermal vibration spectra of MWNTs under ambient conditions showed that the elastic modulus, E, of plasma-enhanced chemical vapor deposition (PECVD) MWNTs is 37 {+-} 26 GPa, well within the range of E previously reported for CVD-grown MWNTs. Since the Ag{sub 2}Ga nanoneedles have a greater optical scattering efficiency than MWNTs

  5. Full field frequency domain common path optical coherence tomography with annular aperture

    NASA Astrophysics Data System (ADS)

    Abdulhalim, I.; Friedman, Ron; Liraz, Lior; Dadon, Ronen

    2007-07-01

    Theoretical and experimental results are presented using the common path Mirau interference microscope and using the Linnik microscope with annular masks to increase the depth of field. The competence between the spatial and temporal coherence was investigated theoretically and confirmed experimentally. Phase imaging of onion epidermis cells was presented showing the possibility of obtaining profiles of the cells. Frequency domain OCT was shown to be possible using full field setup.

  6. Full-field interferometric confocal microscopy using a VCSEL array

    PubMed Central

    Redding, Brandon; Bromberg, Yaron; Choma, Michael A.; Cao, Hui

    2014-01-01

    We present an interferometric confocal microscope using an array of 1200 VCSELs coupled to a multimode fiber. Spatial coherence gating provides ~18,000 continuous virtual pinholes allowing an entire en face plane to be imaged in a snapshot. This approach maintains the same optical sectioning as a scanning confocal microscope without moving parts, while the high power of the VCSEL array (~5 mW per laser) enables high-speed image acquisition with integration times as short as 100 µs. Interferometric detection also recovers the phase of the image, enabling quantitative phase measurements and improving the contrast when imaging phase objects. PMID:25078199

  7. Full field electron spectromicroscopy applied to ferroelectric materials

    NASA Astrophysics Data System (ADS)

    Barrett, N.; Rault, J. E.; Wang, J. L.; Mathieu, C.; Locatelli, A.; Mentes, T. O.; Niño, M. A.; Fusil, S.; Bibes, M.; Barthélémy, A.; Sando, D.; Ren, W.; Prosandeev, S.; Bellaiche, L.; Vilquin, B.; Petraru, A.; Krug, I. P.; Schneider, C. M.

    2013-05-01

    The application of PhotoEmission Electron Microscopy (PEEM) and Low Energy Electron Microscopy (LEEM) techniques to the study of the electronic and chemical structures of ferroelectric materials is reviewed. Electron optics in both techniques gives spatial resolution of a few tens of nanometres. PEEM images photoelectrons, whereas LEEM images reflected and elastically backscattered electrons. Both PEEM and LEEM can be used in direct and reciprocal space imaging. Together, they provide access to surface charge, work function, topography, chemical mapping, surface crystallinity, and band structure. Examples of applications for the study of ferroelectric thin films and single crystals are presented.

  8. Halo suppression in full-field x-ray Zernike phase contrast microscopy.

    PubMed

    Vartiainen, Ismo; Mokso, Rajmund; Stampanoni, Marco; David, Christian

    2014-03-15

    Visible light Zernike phase contrast (ZPC) microscopy is a well established method for imaging weakly absorbing samples. The method is also used with hard x-ray photon energies for structural evaluation of material science and biological applications. However, the method suffers from artifacts that are inherent for the Zernike image formation. In this Letter, we investigate their origin and experimentally show how to suppress them in x-ray full-field ZPC microscopy based on diffractive x-ray optics. PMID:24690848

  9. Full-field interferometric confocal microscopy using a VCSEL array.

    PubMed

    Redding, Brandon; Bromberg, Yaron; Choma, Michael A; Cao, Hui

    2014-08-01

    We present an interferometric confocal microscope using an array of 1200 vertical cavity surface emitting lasers (VCSELs) coupled to a multimode fiber. Spatial coherence gating provides ~18,000 continuous virtual pinholes, allowing an entire en face plane to be imaged in a snapshot. This approach maintains the same optical sectioning as a scanning confocal microscope without moving parts, while the high power of the VCSEL array (∼5  mW per laser) enables high-speed image acquisition with integration times as short as 100 μs. Interferometric detection also recovers the phase of the image, enabling quantitative phase measurements and improving the contrast when imaging phase objects. PMID:25078199

  10. Full-field spatially incoherent illumination interferometry: a spatial resolution almost insensitive to aberrations.

    PubMed

    Xiao, Peng; Fink, Mathias; Boccara, A Claude

    2016-09-01

    We show that with spatially incoherent illumination, the point spread function (PSF) width/spatial resolution of an imaging interferometer like that used in full-field optical coherence tomography (OCT) is almost insensitive to aberrations. In these systems, aberrations mostly induce a reduction of the signal level that leads to a loss of the signal-to-noise ratio without broadening the system PSF. This is demonstrated by comparison with traditional scanning OCT and wide-field OCT with spatially coherent illuminations. Theoretical analysis and numerical calculation as well as experimental results are provided to show this specific merit of incoherent illumination in full-field OCT. To the best of our knowledge, this is the first time that such a result has been demonstrated. PMID:27607937

  11. Effect of oxymetazoline on nasal and sinus mucosal blood flow in the rabbit as measured with laser-Doppler flowmetry.

    PubMed

    Akerlund, A; Arfors, K E; Bende, M; Intaglietta, M

    1993-02-01

    The effect of topical oxymetazoline hydrochloride on the blood flow of the nasal and sinus mucosa of the rabbit was measured by laser-Doppler flowmetry. Oxymetazoline, the active component in clinically used nose drops, induced a dose-dependent decrease of the nasal mucosal blood flow. This effect has previously been shown in humans and suggests the presence of alpha 2-adrenoceptors in the nasal mucosa of the rabbit. Doses of oxymetazoline used clinically in humans induced a 50% reduction of blood flow in rabbits. Rhythmic variations in blood flow were seen in 30% of the rabbits after administration of oxymetazoline. Additionally, oxymetazoline induced a dose-dependent decrease of the mucosal blood flow in the maxillary sinus when the drug was applied in the nose. A vasoconstricting effect of oxymetazoline on the arteries penetrating the maxillary sinus ostium is a possible explanation. This can have positive as well as negative consequences on acute sinus infections.

  12. A feasibility study for the detection of upper atmospheric winds using a ground based laser Doppler velocimeter

    NASA Technical Reports Server (NTRS)

    Thomson, J. A. L.; Meng, J. C. S.

    1975-01-01

    A possible measurement program designed to obtain the information requisite to determining the feasibility of airborne and/or satellite-borne LDV (Laser Doppler Velocimeter) systems is discussed. Measurements made from the ground are favored over an airborne measurement as far as for the purpose of determining feasibility is concerned. The expected signal strengths for scattering at various altitude and elevation angles are examined; it appears that both molecular absorption and ambient turbulence degrade the signal at low elevation angles and effectively constrain the ground based measurement of elevation angles exceeding a critical value. The nature of the wind shear and turbulence to be expected are treated from a linear hydrodynamic model - a mountain lee wave model. The spatial and temporal correlation distances establish requirements on the range resolution, the maximum detectable range and the allowable integration time.

  13. Conceptual design of an airborne laser Doppler velocimeter system for studying wind fields associated with severe local storms

    NASA Technical Reports Server (NTRS)

    Thomson, J. A. L.; Davies, A. R.; Sulzmann, K. G. P.

    1976-01-01

    An airborne laser Doppler velocimeter was evaluated for diagnostics of the wind field associated with an isolated severe thunderstorm. Two scanning configurations were identified, one a long-range (out to 10-20 km) roughly horizontal plane mode intended to allow probing of the velocity field around the storm at the higher altitudes (4-10 km). The other is a shorter range (out to 1-3 km) mode in which a vertical or horizontal plane is scanned for velocity (and possibly turbulence), and is intended for diagnostics of the lower altitude region below the storm and in the out-flow region. It was concluded that aircraft flight velocities are high enough and severe storm lifetimes are long enough that a single airborne Doppler system, operating at a range of less than about 20 km, can view the storm area from two or more different aspects before the storm characteristics change appreciably.

  14. Investigations of slip in capillary flow by laser-Doppler velocimetry and their relations to melt fracture

    NASA Astrophysics Data System (ADS)

    Münstedt, Helmut

    2015-04-01

    Flow profiles within a slit capillary are measured by laser-Doppler velocimetry. They allow the direct determination of the slip velocity at the wall. It is demonstrated that the flow profile of the melt of a high density polyethylene (HDPE) already shows slip components at small shear rates. At high shear rates the slip is dominant and a plug flow is found. Furthermore, it is shown that the surface irregularity called "shark skin" is generated at the slit exit by the stretching of surface layers at pronounced elongational rates. These elongational rates are due to the differences between the flow velocities at the wall of the slit and those of the extruded strand. It is shown how "shark skin" may be avoided when the elongational rate is reduced by introducing slip of the melt in the slit using special additives.

  15. An LDA (Laser-Doppler Anemometry) investigation of three-dimensional normal shock wave boundary-layer interactions

    NASA Technical Reports Server (NTRS)

    Chriss, R. M.; Hingst, W. R.; Strazisar, A. J.; Keith, T. G., Jr.

    1989-01-01

    Nonintrusive measurements were made of a normal shock wave/boundary layer interaction. Two dimensional measurements were made throughout the interaction region while 3-D measurements were made in the vicinity of the shock wave. The measurements were made in the corner of the test section of a continuous supersonic wind tunnel in which a normal shock wave had been stabilized. Laser Doppler Anemometry, surface pressure measurement and flow visualization techniques were employed for two freestream Mach number test cases: 1.6 and 1.3. The former contained separated flow regions and a system of shock waves. The latter was found to be far less complicated. The results define the flow field structure in detail for each case.

  16. Three-dimensional ray tracing through curvilinear interfaces with application to laser Doppler anemometry in a blood analogue fluid.

    PubMed

    Nugent, Allen H; Bertram, Christopher D

    2010-02-01

    Prediction of the effects of refractive index (RI) mismatch on laser Doppler anemometer (LDA) measurements within a curvilinear cavity (an artificial ventricle) was achieved by developing a general technique for modelling the paths of the convergent beams of the LDA system using 3D vector geometry. Validated by ray tracing through CAD drawings, the predicted maximum tolerance in RI between the solid model and the working fluid was +/- 0.0005, equivalent to focusing errors commensurate with the geometric and alignment uncertainties associated with the flow model and the LDA arrangement. This technique supports predictions of the effects of refraction within a complex geometry. Where the RI mismatch is unavoidable but known, it is possible not only to calculate the true position of the measuring volume (using the probe location and model geometry), but also to estimate degradation in signal quality arising from differential displacement and refraction of the laser beams.

  17. Three-dimensional ray tracing through curvilinear interfaces with application to laser Doppler anemometry in a blood analogue fluid.

    PubMed

    Nugent, Allen H; Bertram, Christopher D

    2010-02-01

    Prediction of the effects of refractive index (RI) mismatch on laser Doppler anemometer (LDA) measurements within a curvilinear cavity (an artificial ventricle) was achieved by developing a general technique for modelling the paths of the convergent beams of the LDA system using 3D vector geometry. Validated by ray tracing through CAD drawings, the predicted maximum tolerance in RI between the solid model and the working fluid was +/- 0.0005, equivalent to focusing errors commensurate with the geometric and alignment uncertainties associated with the flow model and the LDA arrangement. This technique supports predictions of the effects of refraction within a complex geometry. Where the RI mismatch is unavoidable but known, it is possible not only to calculate the true position of the measuring volume (using the probe location and model geometry), but also to estimate degradation in signal quality arising from differential displacement and refraction of the laser beams. PMID:19669821

  18. Rotor redesign for a highly loaded 1800 ft/sec tip speed fan. 3: Laser Doppler velocimeter report

    NASA Technical Reports Server (NTRS)

    Harvey, W. B.; Hobbs, D. E.; Lee, D.; Williams, M. C.; Williams, K. F.

    1982-01-01

    Laser Doppler velocimeter (LDV) techniques were employed for testing a highly loaded, 550 m/sec (1800 ft/sec) tip speed, test fan stage, the objective to provide detailed mapping of the upstream, intrablade, and downstream flowfields of the rotor. Intrablade LDV measurements of velocity and flow angle were obtained along four streamlines passing through the leading edge at 45%, 69%, 85%, and 95% span measured from hub to tip, at 100% of design speed, peak efficiency; 100% speed, near surge; and 95% speed, peak efficiency. At the design point, most passages appeared to have a strong leading edge shock, which moved forward with increasing strength near surge and at part speeds. The flow behind the shock was of a complex mixed subsonic and supersonic form. The intrablade flowfields were found to be significantly nonperiodic at 100% design speed, peak efficiency.

  19. Laser Doppler velocimetry based on the optoacoustic effect in a RF-excited CO{sub 2} laser

    SciTech Connect

    Lee, Teaghee; Choi, Jong Woon; Kim, Yong Pyung

    2012-09-15

    We present a compact optoacoustic laser Doppler velocimetry method that utilizes the self-mixing effect in a RF-excited CO{sub 2} laser. A portion of a Doppler-shifted laser beam, produced by irradiating a single wavelength laser beam on a moving object, is mixed with an originally existing laser beam inside a laser cavity. The fine change of pressure in the laser cavity modulated by the Doppler-shifted frequency is detected by a condenser microphone in the laser tube. In our studies, the frequency of the Doppler signal due to the optoacoustic effect was detected as high as 50 kHz. Our measurements also confirmed that the signal varied linearly with the velocity of the external scatterer (the moving object) and the cosine of the angle between the laser beam and the velocity vector of the object.

  20. Development of a wireless sensor for the measurement of chicken blood flow using the laser Doppler blood flow meter technique.

    PubMed

    Nishihara, Kei; Iwasaki, Wataru; Nakamura, Masaki; Higurashi, Eiji; Soh, Tomoki; Itoh, Toshihiro; Okada, Hironao; Maeda, Ryutaro; Sawada, Renshi

    2013-06-01

    Here, we report the development of an integrated laser Doppler blood flow micrometer for chickens. This sensor weighs only 18 g and is one of the smallest-sized blood flow meters, with no wired line, these are features necessary for attaching the sensor to the chicken. The structure of the sensor chip consists of two silicon cavities with a photo diode and a laser diode, which was achieved using the microelectromechanical systems technique, resulting in its small size and significantly low power consumption. In addition, we introduced an intermittent measuring arrangement in the measuring system to reduce power consumption and to enable the sensor to work longer. We were successfully able to measure chicken blood flow for five consecutive days, and discovered that chicken blood flow shows daily fluctuations.

  1. Detection and localization of rib detachment in thin metal and composite plates by inversion of laser Doppler vibrometry scans.

    PubMed

    Romano, Anthony J; Bucaro, Joseph A; Vignola, Joseph F; Abraham, Phillip B

    2007-05-01

    The laboratory implementation of a fault detection and localization method based on inversion of dynamic surface displacements measured by a scanned laser Doppler vibrometer (SLDV) was investigated. The technique uses flexural wave and generalized force inversion algorithms which have previously been demonstrated using simulated noise-free vibration data generated for thick plates with a finite element model. Here these inversion algorithms to SLDV measurements made in the laboratory on a thin nickel plate and a thin carbon fiber composite plate, both having attached reinforcing ribs with intentional de-bonding of the rib/plate interface at a specific location on each structure are applied. The inverted displacement maps clearly detect and locate the detachment, whereas direct observation of the surface displacements does not. It is shown that the technique is relatively robust to the choice of frequency and to the presence of noise.

  2. Intraoperative prediction of ischaemic injury of the bowel: a comparison of laser Doppler flowmetry and tissue oximetry to histological analysis.

    PubMed

    Krohg-Sørensen, K; Line, P D; Haaland, T; Horn, R S; Kvernebo, K

    1992-09-01

    Intraoperative diagnosis of inadequate colonic perfusion would contribute to prevention of ischaemic colitis after abdominal aortic reconstructions. The aim of this study was to evaluate laser Doppler flowmetry (LDF) and tissue oximetry (TpO2) as predictors of the development of bowel necrosis. Devascularised loops of colon and ileum in anaesthetised pigs were divided into 10-20 mm segments and measurements of laser Doppler flux and TpO2 were performed in each segment. After 7 h of ischaemia the segments were resected for histological and biochemical analysis. In 65 colonic and 58 ileal segments a significantly lower flux was found in segments with necrosis of greater than or equal to 30% of the mucosal thickness compared to segments with necrosis of less than or equal to 10% (p less than 0.01). The discriminant flux value was 50 perfusion units, confirming a previous clinical study. The specificity was 0.96 and the sensitivity 0.94. Flux was inversely correlated to tissue lactate concentration. Significantly lower TpO2 was found in 19 colonic segments with necrosis of greater than or equal to 30% of mucosa compared to 19 colonic segments with necrosis of less than or equal to 10% (p less than 0.01). Using a discriminant value of 5kPa, a specificity of 0.79, and a sensitivity of 0.95 were calculated. In 27 ileum segments no significant difference in TpO2 between different histological groups was found (p greater than 0.30). The results show that LDF and TpO2 can predict ischaemic injury of the colon, and LDF also of the small bowel. PMID:1397347

  3. Laser Doppler line scanner for monitoring skin perfusion changes of port wine stains during vascular-targeted photodynamic therapy

    NASA Astrophysics Data System (ADS)

    Chen, Defu; Ren, Jie; Wang, Ying; Gu, Ying

    2014-11-01

    Vascular-targeted photodynamic therapy (V-PDT) is known to be an effective therapeutic modality for the treatment of port wine stains (PWS). Monitoring the PWS microvascular response to the V-PDT is crucial for improving the effectiveness of PWS treatment. The objective of this study was to use laser Doppler technique to directly assess the skin perfusion in PWS before and during V-PDT. In this study, 30 patients with PWS were treated with V-PDT. A commercially laser Doppler line scanner (LDLS) was used to record the skin perfusion of PWS immediately before; and at 1, 3, 5, 7, 10, 15 and 20 minutes during V-PDT treatment. Our results showed that there was substantial inter- and intra-patient perfusion heterogeneity in PWS lesion. Before V-PDT, the comparison of skin perfusion in PWS and contralateral healthy control normal skin indicated that PWS skin perfusion could be larger than, or occasionally equivalent to, that of control normal skin. During V-PDT, the skin perfusion in PWS significantly increased after the initiation of V-PDT treatment, then reached a peak within 10 minutes, followed by a slowly decrease to a relatively lower level. Furthermore, the time for reaching peak and the subsequent magnitude of decrease in skin perfusion varied with different patients, as well as different PWS lesion locations. In conclusion, the LDLS system is capable of assessing skin perfusion changes in PWS during V-PDT, and has potential for elucidating the mechanisms of PWS microvascular response to V-PDT.

  4. Optical biopsy on head and neck tissue using full-field OCT: a pilot study

    NASA Astrophysics Data System (ADS)

    De Leeuw, Frédéric; Latrive, Anne; Casiraghi, Odile; Ferchiou, Malek; Harms, Fabrice; Boccara, Claude; Laplace-Builhé, Corinne

    2014-03-01

    Here we evaluate the clinical value of Full-Field OCT imaging in the management of patients with Head and Neck cancers by making a reliable histological diagnosis on FFOCT images produced during preoperative procedure. FFOCT performs a true "virtual extemporaneous exam" that we want to compare to the gold standard (extemporaneous and conventional histology with H and E staining). This new optical technology could be useful when diagnosing a lesion, cancerous or precancerous, or at the time of its surgical management. Full-Field Optical Coherence Tomography virtually slices the tissue using white light interferometry to produce in-depth 2D images with an isotropic resolution around 1 micrometer. With such a high resolution FFOCT systems produce "optical biopsy" images that are similar to that obtained with classical histology procedures, but without any staining and in only a few minutes. We imaged freshly excised samples from patients, of mouth, tongue, epiglottis and larynx tissues, both healthy and cancerous. FFOCT images were acquired and later compared with histology of the same samples. Common features were identified and characteristics of each tissue type were matched in order to form an image atlas for pathologist training. We were able to identify indicators of tumors such as heterogeneities in cell distribution, surrounding stroma, anomalous keratinization… In conclusion, FFOCT is a fast, non-invasive, non-destructive imaging tool that can be inserted into the pathology lab workflow and can provide a quick assessment of microscopic tissue architecture and content. Furthermore we are developing a similar system with a rigid endoscopic probe in order to do in vivo and in situ high-resolution imaging. Our probe could thus guide the surgeon in real time before and during excision and ensure a more precise gesture.

  5. Contrast visibility of simulated microcalcifications in full field mammography systems

    NASA Astrophysics Data System (ADS)

    Carton, Ann-Katherine; Bosmans, Hilde; Van Ongeval, Chantal; Souverijns, Geert; Rogge, Frank; Marchal, Guy

    2003-05-01

    We evaluated the visibility of simulated subtle microcalcifications in real digital mammograms acquired with a flat-panel system (GE) and a CR system (Fuji). Ideal templates of microcalcifications were created, based on the attenuation characteristics of subtle microcalcifications from biopsied specimen in magnified images. X-ray transmission coefficients were expressed in Al-equivalent thickness. In this way, the X-ray transmission of a particular lesion could be re-calculated for other X-ray beams, different mammography systems and for different breast thickness. Extra corrections for differences in spatial resolution were based on the pre-sampled MTF. Zero to 10 simulated microcalcifications were randomly distributed in square frames. These software phantoms were then inserted in sets of raw mammograms of the modalities under study. The composed images were compressed, processed and printed as in clinical routine. Two experienced radiologists indicated the locations of the microcalcifications and rated their detection confidence. It is possible to assess the visibility of 'well controlled" microcalcifications in digital clinical mammograms. Microcalcifications were better visible in the CR images than in the flat panel images. This psychophysical method comes close to the radiologists" practice. It allows fpr including processing and visualization in the analysis and was well appreciated by our radiologists.

  6. En-face full-field optical coherence tomography for fast and efficient fingerprints acquisition

    NASA Astrophysics Data System (ADS)

    Harms, Fabrice; Dalimier, Eugénie; Boccara, A. Claude

    2014-05-01

    Optical coherence tomography (OCT) has been recently proposed by a number of laboratories as a promising tool for fingerprints acquisitions and for fakes discrimination. Indeed OCT being a non-contact, non-destructive optical method that virtually sections the volume of biological tissues that strongly scatter light it appears obvious to use it for fingerprints. Nevertheless most of the OCT setups have to go through the long acquisition of a full 3D image to isolate an "en-face" image suitable for fingerprint analysis. A few "en-face" OCT approaches have been proposed that use either a complex 2D scanning setup and image processing, or a full-field illumination using a camera and a spatially coherent source that induces crosstalks and degrades the image quality. We show here that Full Field OCT (FFOCT) using a spatially incoherent source is able to provide "en-face" high quality optical sectioning of the fingers skin. Indeed such approach shows a unique spatial resolution able to reveal a number of morphological details of fingerprints that are not seen with competing OCT setups. In particular the cellular structure of the stratum corneum and the epidermis-dermis interface appear clearly. We describe our high-resolution (1 micrometer, isotropic) setup and show our first design to get a large field of view while keeping a good sectioning ability of about 3 micrometers. We display the results obtained using these two setups for fingerprints examination.

  7. Full-field measurement of surface reflectivity using a microscopy for refractive index profiling of GRIN lenses

    NASA Astrophysics Data System (ADS)

    Weng, Chun-Jen; Chen, Chih-Yen; Hwang, Chi-Hung; Liu, Da-Ren

    2016-07-01

    This paper outlines an improved technique for profiling the refractive index of Graded-index (GRIN) lenses based on the measurements obtained from a reflectivity image. Reflective cross-sectional image of the GRIN lens were compared with a reflectance reference target under illumination at small incidence angles to obtain the full-field refractive index distribution of the GRIN lens quickly and easily.

  8. Three Dimensional Mapping of Nicle Oxidation States Using Full Field Xray Absorption Near Edge Structure Nanotomography

    SciTech Connect

    Nelson, G.J.; Chu, Y.; Harris, W.M.; Izzo, J.R.; Grew, K.N., Chiu, W.K.S.; Yi, J.; Andrews, J.C.; Liu, Y., Pierro, P.

    2011-04-28

    The reduction-oxidation cycling of the nickel-based oxides in composite solid oxide fuel cells and battery electrodes is directly related to cell performance. A greater understanding of nickel redox mechanisms at the microstructural level can be achieved in part using transmission x-ray microscopy (TXM) to explore material oxidation states. X-ray nanotomography combined with x-ray absorption near edge structure (XANES) spectroscopy has been applied to study samples containing distinct regions of nickel and nickel oxide (NiO) compositions. Digitally processed images obtained using TXM demonstrate the three-dimensional chemical mapping and microstructural distribution capabilities of full-field XANES nanotomography.

  9. High-resolution full-field spatial coherence gated optical tomography using monochromatic light source

    NASA Astrophysics Data System (ADS)

    Srivastava, Vishal; Nandy, Sreyankar; Singh Mehta, Dalip

    2013-09-01

    We demonstrate dispersion free, high-resolution full-field spatial coherence gated optical tomography using spatially incoherent monochromatic light source. Spatial coherence properties of light source were synthesized by means of combining a static diffuser and vibrating multi mode fiber bundle. Due to low spatial coherence of light source, the axial resolution of the system was achieved similar to that of conventional optical coherence tomography which utilizes low temporal coherence. Experimental results of fringe visibility versus optical path difference are presented for varying numerical apertures objective lenses. High resolution optically sectioned images of multilayer onion skin, and red blood cells are presented.

  10. Automatic exposure control for a slot scanning full field digital mammography system

    SciTech Connect

    Elbakri, Idris A.; Lakshminarayanan, A.V.; Tesic, Mike M.

    2005-09-15

    Automatic exposure control (AEC) is an important feature in mammography. It enables consistently optimal image exposure despite variations in tissue density and thickness, and user skill level. Full field digital mammography systems cannot employ conventional AEC methods because digital receptors fully absorb the x-ray beam. In this paper we describe an AEC procedure for slot scanning mammography. With slot scanning detectors, our approach uses a fast low-resolution and low-exposure prescan to acquire an image of the breast. Tube potential depends on breast thickness, and the prescan histogram provides the necessary information to calculate the required tube current. We validate our approach with simulated prescan images and phantom measurements. We achieve accurate exposure tracking with thickness and density, and expect this method of AEC to reduce retakes and improve workflow.

  11. Effective x-ray attenuation measurements with full field digital mammography

    SciTech Connect

    Heine, John J.; Behera, Madhusmita

    2006-11-15

    This work shows that effective x-ray attenuation coefficients may be estimated by applying Beer's Law to phantom image data acquired with the General Electric Senographe 2000D full field digital mammography system. Theoretical developments are provided indicating that an approximate form of the Beer's relation holds for polychromatic x-ray beams. The theoretical values were compared with experimentally determined measured values, which were estimated at various detector locations. The measured effective attenuation coefficients are in agreement with those estimated with theoretical developments and numerical integration. The work shows that the measured quantities show little spatial variation. The main ideas are demonstrated with polymethylmethacrylate and breast tissue equivalent phantom imaging experiments. The work suggests that the effective attenuation coefficients may be used as known values for radiometric standardization applications that compensate for the image acquisition influences. The work indicates that it is possible to make quantitative attenuation coefficient measurements from a system designed for clinical purposes.

  12. Applying LED in full-field optical coherence tomography for gastrointestinal endoscopy

    NASA Astrophysics Data System (ADS)

    Yang, Bor-Wen; Wang, Yu-Yen; Juan, Yu-Shan; Hsu, Sheng-Jie

    2015-08-01

    Optical coherence tomography (OCT) has become an important medical imaging technology due to its non-invasiveness and high resolution. Full-field optical coherence tomography (FF-OCT) is a scanning scheme especially suitable for en face imaging as it employs a CMOS/CCD device for parallel pixels processing. FF-OCT can also be applied to high-speed endoscopic imaging. Applying cylindrical scanning and a right-angle prism, we successfully obtained a 360° tomography of the inner wall of an intestinal cavity through an FF-OCT system with an LED source. The 10-μm scale resolution enables the early detection of gastrointestinal lesions, which can increase detection rates for esophageal, stomach, or vaginal cancer. All devices used in this system can be integrated by MOEMS technology to contribute to the studies of gastrointestinal medicine and advanced endoscopy technology.

  13. Full-field OCT for fast diagnostic of head and neck cancer

    NASA Astrophysics Data System (ADS)

    De Leeuw, Frederic; Casiraghi, Odile; Ben Lakhdar, Aïcha; Abbaci, Muriel; Laplace-Builhé, Corinne

    2015-02-01

    Full-Field OCT (FFOCT) produces optical slices of tissue using white light interferometry providing in-depth 2D images, with an isotropic resolution around 1 micrometer. These optical biopsy images are similar to those obtained with established histological procedures, but without tissue preparation and within few minutes. This technology could be useful when diagnosing a lesion or at the time of its surgical management. Here we evaluate the clinical value of FFOCT imaging in the management of patients with Head and Neck cancers by assessing the accuracy of the diagnosis done on FFOCT images from resected specimen. FFOCT images from Head and Neck samples were first compared to the gold standard (HES-conventional histology). An image atlas dedicated to the training of pathologists was built and diagnosis criteria were identified. Then, we performed a morphological correlative study: both healthy and cancerous samples from patients who undergo Head and Neck surgery of oral cavity, pharynx, and larynx were imaged. Images were interpreted in a random way by two pathologists and the FFOCT based diagnostics were compared with HES (gold standard) of the same samples. Here we present preliminary results showing that FFOCT provides a quick assessment of tissue architecture at microscopic level that could guide surgeons for tumor margin delineation during intraoperative procedure.

  14. Scatter radiation intensities around full-field digital mammography units.

    PubMed

    Judge, M A; Keavey, E; Phelan, N

    2013-01-01

    The aim of this study was to investigate the scatter radiation intensity around digital mammography systems and apply these data to standard shielding calculations to reveal whether shielding design of existing breast screening rooms is adequate for the use of digital mammography systems. Three digital mammography systems from GE Healthcare, Hologic and Philips were employed in the study. A breast-equivalent phantom was imaged under clinical workload conditions and scatter radiation intensities around the digital mammography systems were measured for a range of angles in three planes using an ionisation chamber. The results were compared with those from previous studies of film-screen systems. It may be deduced from the results that scattering in the backward direction is significant for all three systems, while scattering in the forward direction can be significant for some planes around the GE and Hologic systems. Measurements at typical clinical settings on each system revealed the Philips system to have markedly lower scatter radiation intensities than the other systems. Substituting the measured scattered radiation intensity into shielding calculations yielded barrier requirements similar to those already in place at the screening centres operating these systems. Current radiation protection requirements based on film-screen technology remain sufficient when applied to rooms with digital mammography installations and no alteration is required to the structural shielding.

  15. Full-field IR measurement of subsurface grinding temperatures

    NASA Astrophysics Data System (ADS)

    Sakagami, Takahide; Madhavan, Viswanathan; Harish, G.; Krishnamurthy, K.; Ju, Yongqing; Farris, Thomas N.; Chandrasekar, Srinivasan

    1998-03-01

    A multiple-element, forward looking IR system is used to measure the subsurface temperature field produced by dry grinding of steel with both aluminum oxide and cubic boron nitride (CBN) grinding wheels. The technique is base don imaging the IR radiation obtained from the side of the specimen. A recent theoretical analysis of heat partition and surface temperatures in grinding is reviewed. The analysis partitions heat on the two length scales pertinent to grinding between the workpiece, wheel, coolant and chips. Spectral analysis is combined with FFT techniques to calculate subsurface temperature contours from the predicted heat partition. The numerical predictions of the model are shown to agree wit the experimental results taken for a range of grinding conditions. It is found that heat partition varies over a wide range depending on grinding conditions. Also, heat partition is a strong function of position inside the grinding zone. The presence of the fluid inside the grinding zone can reduce the heat flux into the workpiece and the workpiece temperature significantly. For typical grinding of steel with CBN, or creep feed grinding of steel with aluminum oxide or CBN, it is possible to keep the fluid active and therefore to reduce thermal damage. However, the analysis suggests that the fluid may not be effective inside the grinding zone, in the conventional grinding of steel with aluminum oxide, due to boiling. It is also found that a moderate ratio of the workpiece velocity to wheel velocity gives high temperatures and therefore should be avoided.

  16. Evaluation of Computer-aided Diagnosis on a Large Clinical Full-Field Digital Mammographic Dataset

    PubMed Central

    Li, Hui; Giger, Maryellen L.; Yuan, Yading; Chen, Weijie; Horsch, Karla; Lan, Li; Jamieson, Andrew R.; Sennett, Charlene A.; Jansen, Sanaz A.

    2008-01-01

    Rationale and Objectives: To convert and optimize our previously developed computerized analysis methods for use with images from full-field digital mammography (FFDM) for breast mass classification in order to aid in the diagnosis of breast cancer. Materials and Methods: An institutional review board approved protocol was obtained, with waiver of consent for retrospective use of mammograms and pathology data. Seven hundreds and thirty-nine full-field digital mammographic images, which contained 287 biopsy-proven breast mass lesions, of which 148 lesions were malignant and 139 lesions were benign, were retrospectively collected. Lesion margins were delineated by an expert breast radiologist and were used as the truth for lesion-segmentation evaluation. Our computerized image analysis method consisted of several steps: 1) identified lesions were automatically extracted from the parenchymal background using computerized segmentation methods; 2) a set of image characteristics (mathematical descriptors) were automatically extracted from image data of the lesions and surrounding tissues; and 3) selected features were merged into an estimate of the probability of malignancy using a Bayesian artificial neural network classifier. Performance of the analyses was evaluated at various stages of the conversion using receiver operating characteristic (ROC) analysis. Results: An AUC value of 0.81 was obtained in the task of distinguishing between malignant and benign mass lesions in a round-robin by case evaluation on the entire FFDM dataset. We failed to show a statistically significant difference (P value=0.83) as compared with results from our previous study in which the computerized classification was performed on digitized screen-film mammograms (SFMD). Conclusion: Our computerized analysis methods developed on digitized screen-film mammography can be converted for use with FFDM. Results show that the computerized analysis methods for the diagnosis of breast mass lesions on

  17. Full-field dynamic deformation and strain measurements using high-speed digital cameras

    NASA Astrophysics Data System (ADS)

    Schmidt, Timothy E.; Tyson, John; Galanulis, Konstantin; Revilock, Duane M.; Melis, Matthew E.

    2005-03-01

    Digital cameras are rapidly supplanting film, even for very high speed and ultra high-speed applications. The benefits of these cameras, particularly CMOS versions, are well appreciated. This paper describes how a pair of synchronized digital high-speed cameras can provide full-field dynamic deformation, shape and strain information, through a process known as 3D image correlation photogrammetry. The data is equivalent to thousands of non-contact x-y-z extensometers and strain rosettes, as well as instant non-contact CMM shape measurement. A typical data acquisition rate is 27,000 frames per second, with displacement accuracy on the order of 25-50 microns, and strain accuracy of 250-500 microstrain. High-speed 3D image correlation is being used extensively at the NASA Glenn Ballistic Impact Research Lab, in support of Return to Flight activities. This leading edge work is playing an important role in validating and iterating LS-DYNA models of foam impact on reinforced carbon-carbon, including orbiter wing panel tests. The technique has also been applied to air blast effect studies and Kevlar ballistic impact testing. In these cases, full-field and time history analysis revealed the complexity of the dynamic buckling, including multiple lobes of out-of-plane and in-plane displacements, strain maxima shifts, and damping over time.

  18. Investigation of a laser Doppler velocimeter system to measure the flow field around a large scale V/STOL aircraft in ground effect

    NASA Technical Reports Server (NTRS)

    Zalay, A. D.; Brashears, M. R.; Jordan, A. J.; Shrider, K. R.; Vought, C. D.

    1979-01-01

    The flow field measured around a hovering 70 percent scale vertical takeoff and landing (V/STOL) aircraft model is described. The velocity measurements were conducted with a ground based laser Doppler velocimeter. The remote sensing instrumentation and experimental tests of the velocity surveys are discussed. The distribution of vertical velocity in the fan jet and fountain; the radial velocity in the wall jet and the horizontal velocity along the aircraft underside are presented for different engine rpms and aircraft height above ground. Results show that it is feasible to use a mobile laser Doppler velocimeter to measure the flow field generated by a large scale V/STOL aircraft operating in ground effect.

  19. Investigation of a laser Doppler velocimeter system to measure the flow field of a large scale V/STOL aircraft in ground effect

    NASA Technical Reports Server (NTRS)

    Zalay, A. D.; Brashears, M. R.; Jordan, A. J.; Shrider, K. R.; Vought, C. D.

    1979-01-01

    An experimental research program for measuring the flow field around a 70 percent scale V/STOL aircraft model in ground effect is described. The velocity measurements were conducted with a ground-based laser Doppler velocimeter at an outdoor test pad. The remote sensing instrumentation, experimental tests, and results of the velocity surveys are discussed. The distribution of vertical velocity in the fan jet and fountain, the radial velocity in the wall jet and the horizontal velocity along the aircraft underside are presented for different engine rpms and aircraft heights above ground. The study shows that it is feasible to use a mobile laser Doppler velocimeter to measure the flow field generated by a large scale V/STOL aircraft operating in ground effect.

  20. Spontaneous laser doppler flux distribution in ischemic ulcers and the effect of prostanoids: a crossover study comparing the acute action of prostaglandin E1 and iloprost vs saline.

    PubMed

    Gschwandtner, M E; Koppensteiner, R; Maca, T; Minar, E; Schneider, B; Schnürer, G; Ehringer, H

    1996-01-01

    The flux distribution within ischemic ulcers and adjacent skin and its change by prostanoids was investigated using laser Doppler flux scanning. A prostanoid-induced increase in ulcer flux could be a rationale for the improved wound healing. In a single-blind prospective study 18 patients received prostaglandin E1 (PGE1) (333.3 ng/min.), iloprost (41.7 ng/min final dose), and 0.9% saline in a randomized order. The average laser Doppler flux within the ulcer (LFU, x +/- SEM, arbitrary units) or in the adjacent skin (LFS) was evaluated before and 30, 60, 90, and 120 min after prostanoid/saline infusion. LFU increased with PGE1 from 2.30 +/- 0.27 to 3.08 +/- 0.31 (+33.9%; P < 0.001) and with iloprost from 2.37 +/- 0.26 to 3.03 +/- 0.27 (+27.8%; P < 0.001) after 120 min, respectively. Saline did not change LFU significantly: 2.19 +/- 0.18 vs 2.55 +/- 0.26 (+16.4%; P > 0.05). Simultaneously, LFS was not significantly changed when pretreatment values were compared with mean flux at 120 min: PGE1 2.13 +/- 0.27 vs 2.54 +/- 0.34, iloprost 2.03 +/- 0.26 vs 1.94 +/- 0.21, and saline 1.74 +/- 0.27 vs 1.92 +/- 0.30 (P > 0.05, each), respectively. The laser Doppler flux scanning technique might be a tool to study the distribution of laser Doppler flux within ischemic ulcers. This might be useful to study the physiological or pathophysiological control of flux within ischemic ulcers as well as possible therapeutic approaches. PMID:8812752

  1. Applications of Hard X-ray Full-Field Transmission X-ray Microscopy at SSRL

    NASA Astrophysics Data System (ADS)

    Liu, Y.; Andrews, J. C.; Meirer, F.; Mehta, A.; Gil, S. Carrasco; Sciau, P.; Mester, Z.; Pianetta, P.

    2011-09-01

    State-of-the-art hard x-ray full-field transmission x-ray microscopy (TXM) at beamline 6-2C of Stanford Synchrotron Radiation Lightsource has been applied to various research fields including biological, environmental, and material studies. With the capability of imaging a 32-micron field-of-view at 30-nm resolution using both absorption mode and Zernike phase contrast, the 3D morphology of yeast cells grown in gold-rich media was investigated. Quantitative evaluation of the absorption coefficient was performed for mercury nanoparticles in alfalfa roots exposed to mercury. Combining XANES and TXM, we also performed XANES-imaging on an ancient pottery sample from the Roman pottery workshop at LaGraufesenque (Aveyron).

  2. Applications of Hard X-ray Full-Field Transmission X-ray Microscopy at SSRL

    SciTech Connect

    Liu, Y.; Andrews, J. C.; Mehta, A.; Pianetta, P.; Meirer, F.; Gil, S. Carrasco; Sciau, P.; Mester, Z.

    2011-09-09

    State-of-the-art hard x-ray full-field transmission x-ray microscopy (TXM) at beamline 6-2C of Stanford Synchrotron Radiation Lightsource has been applied to various research fields including biological, environmental, and material studies. With the capability of imaging a 32-micron field-of-view at 30-nm resolution using both absorption mode and Zernike phase contrast, the 3D morphology of yeast cells grown in gold-rich media was investigated. Quantitative evaluation of the absorption coefficient was performed for mercury nanoparticles in alfalfa roots exposed to mercury. Combining XANES and TXM, we also performed XANES-imaging on an ancient pottery sample from the Roman pottery workshop at LaGraufesenque (Aveyron).

  3. Development of hard X-ray dark-field microscope using full-field optics

    NASA Astrophysics Data System (ADS)

    Takano, Hidekazu; Azuma, Hiroaki; Shimomura, Sho; Tsuji, Takuya; Tsusaka, Yoshiyuki; Kagoshima, Yasushi

    2016-10-01

    We develop a dark-field X-ray microscope using full-field optics based on a synchrotron beamline. Our setup consists of a condenser system and a microscope objective with an angular acceptance larger than that of the condenser. The condenser system is moved downstream from its regular position such that the focus of the condenser is behind the objective. The dark-field microscope optics are configured by excluding the converging beam from the condenser at the focal point. The image properties of the system are evaluated by observing and calculating a Siemens star test chart with 10 keV X-rays. Our setup allows easy switching to bright-field imaging.

  4. A High Resolution Full Field Transmission X-ray Microscope at SSRL

    SciTech Connect

    Luening, Katharina; Pianetta, Piero; Yun Wenbing; Almeida, Eduardo; Meulen, Marjolein van der

    2007-01-19

    The Stanford Synchrotron Radiation Laboratory (SSRL) in collaboration with Xradia Inc., the NASA Ames Research Center and Cornell University is implementing a commercial hard x-ray full field imaging microscope based on zone plate optics on a wiggler beam line on SPEAR3. This facility will provide unprecedented analytical capabilities for a broad range of scientific areas and will enable research on nanoscale phenomena and structures in biology as well as materials science and environmental science. This instrument will provide high resolution x-ray microscopy, tomography, and spectromicroscopy capabilities in a photon energy range between 5-14 keV. The spatial resolution of the TXM microscope is specified as 20 nm exploiting imaging in third diffraction order. This imaging facility will optimally combine the latest imaging technology developed by Xradia Inc. with the wiggler source characteristics at beam line 6-2 at SSRL. This will result in an instrument capable of high speed and high resolution imaging with spectral tunability for spectromicroscopy, element specific and Zernike phase contrast imaging. Furthermore, a scanning microprobe capability will be integral to the system thus allowing elemental mapping and fluorescence yield XANES to be performed with a spatial resolution of about 1 {mu}m without introducing any changes to the optical configuration of the instrument.

  5. A High Resolution Full Field Transmission X-ray Microscope at SSRL

    NASA Astrophysics Data System (ADS)

    Lüning, Katharina; Pianetta, Piero; Yun, Wenbing; Almeida, Eduardo; van der Meulen, Marjolein

    2007-01-01

    The Stanford Synchrotron Radiation Laboratory (SSRL) in collaboration with Xradia Inc., the NASA Ames Research Center and Cornell University is implementing a commercial hard x-ray full field imaging microscope based on zone plate optics on a wiggler beam line on SPEAR3. This facility will provide unprecedented analytical capabilities for a broad range of scientific areas and will enable research on nanoscale phenomena and structures in biology as well as materials science and environmental science. This instrument will provide high resolution x-ray microscopy, tomography, and spectromicroscopy capabilities in a photon energy range between 5-14 keV. The spatial resolution of the TXM microscope is specified as 20 nm exploiting imaging in third diffraction order. This imaging facility will optimally combine the latest imaging technology developed by Xradia Inc. with the wiggler source characteristics at beam line 6-2 at SSRL. This will result in an instrument capable of high speed and high resolution imaging with spectral tunability for spectromicroscopy, element specific and Zernike phase contrast imaging. Furthermore, a scanning microprobe capability will be integral to the system thus allowing elemental mapping and fluorescence yield XANES to be performed with a spatial resolution of about 1 μm without introducing any changes to the optical configuration of the instrument.

  6. High efficiency for prostate biopsy qualification with full-field OCT after training

    NASA Astrophysics Data System (ADS)

    Yang, C.; Ricco, R.; Sisk, A.; Duc, A.; Sibony, M.; Beuvon, F.; Dalimier, E.; Delongchamps, N. B.

    2016-02-01

    Full-field optical coherence tomography (FFOCT) offers a fast and non-destructive method of obtaining images of biological tissues at ultrahigh resolution, approaching traditional histological sections. In the context of prostate cancer diagnosis involving multiple biopsies, FFOCT could be used to validate the cores just after they are obtained in order to guide the number of biopsies to be performed. The aim of the study was to define and test a training protocol for efficient FFOCT prostate biopsy assessment. Three readers (a pathologist with previous experience with FFOCT, a pathologist new to FFOCT, and a urologist new to FFOCT) were trained to read FFOCT images of prostate biopsies on a set of 20 commented zooms (1 mm field of view) and 25 complete images. They were later tested on a set of 115 anonymized and randomized images of prostate biopsies. The results showed that an extra 30 images were necessary for more complete training as compared to prior studies. After training, pathologists obtained 100% sensitivity on high-grade cancer detection and 96% overall specificity; the urologist obtained 88% sensitivity on high-grade cancer and 89% overall specificity. Overall, the readers obtained a mean of 93% accuracy of qualifying malignancy on prostate biopsies. Moreover, the two pathologists showed a steeper learning curve than the urologist. This study demonstrates that a training protocol for such a new imaging modality may be implemented and yield very high efficiency for the pre-histologic detection of malignancy on prostate biopsies.

  7. Fast full-field OCT assessment of clinical tissue specimens (Conference Presentation)

    NASA Astrophysics Data System (ADS)

    Dalimier, Eugénie; Harms, Fabrice; Brossolet, Charles; Benoit, Emilie; Martins, Franck; Boccara, Claude

    2016-03-01

    Full-field optical coherence tomography (FFOCT) offers a non-invasive method of obtaining images of biological tissues at ultrahigh resolution (1µm in all 3 directions) approaching traditional histological sections. Previous clinical studies have shown the high efficiency of this imaging technique for the detection of cancer on various organs. This promises great potential of the technique for an ex-vivo quick analysis of surgical resections or biopsy specimens, in the aim to help the surgeon/radiologist decide on the course of action. Here we will present some of the latest technical developments on a FFOCT system which can produce 1cm2 images with 1 µm resolution in 1 minute. Larger samples, up to 50mm diameter, can also be imaged. Details on the large sample handling, high-speed image acquisition, optimized scanning, and accelerated GPU tiles stitching will be given. Results on the clinical applications for breast, urology, and digestive tissues will also be given. They highlight the relevance of the system characteristics for the detection of cancer on ex-vivo specimens. FFOCT now appears clearly as a very fast and non-destructive imaging technique that provides a quick assessment of the tissue morphology. With the benefit of both new technical developments and clinical validation, it turned into a mature technique to be implemented in the clinical environment. In particular, the technique holds potential for the fast ex-vivo analysis of excision margins or biopsies in the operating room.

  8. O2C Laser Doppler and Digital Photo Analysis for Treatment Evaluation of Beta-Glucan versus Provitamin Pantothenic Acid of Facial Burns.

    PubMed

    Thieme, Daniel; Spilker, Gerald; Lefering, Rolf; Weinand, Christian

    2016-04-01

    Various creams are available for superficial second-degree burns (SSDB) of the face. We evaluated provitamin pantothenic acid versus β-glucan for SSDB of the face using the O2C laser Doppler system and digital photo analysis. Out of 20 patients (January to December 2012) with facial burns, 7 with SSDB of both cheeks were included to our study. Burned cheek wounds were treated using pantothenic acid or β-glucan. Digital photos of marked regions were taken daily from predefined distances. Microcirculation was measured at marked regions for 7 days at scheduled time points using the O2C laser Doppler. Data were evaluated using the SPSS program (SPSS Inc., Chicago, IL). Wounds treated with β-glucan showed faster reepithelialization. O2C laser Doppler measurements showed faster increase in SO2, microvascular perfusion, hemoglobin content, and blood flow. This correlated good with clinical Vancouver Scar Scale results. Although not statistically significant, β-glucan cream therapy of SSDB results in aesthetically superior outcome and faster reepithelialization.

  9. Guided-wave-based damage detection in a composite T-joint using 3D scanning laser Doppler vibrometer

    NASA Astrophysics Data System (ADS)

    Kolappan Geetha, Ganesh; Roy Mahapatra, D.; Srinivasan, Gopalakrishnan

    2012-04-01

    Composite T-joints are commonly used in modern composite airframe, pressure vessels and piping structures, mainly to increase the bending strength of the joint and prevents buckling of plates and shells, and in multi-cell thin-walled structures. Here we report a detailed study on the propagation of guided ultrasonic wave modes in a composite T-joint and their interactions with delamination in the co-cured co-bonded flange. A well designed guiding path is employed wherein the waves undergo a two step mode conversion process, one is due to the web and joint filler on the back face of the flange and the other is due to the delamination edges close to underneath the accessible surface of the flange. A 3D Laser Doppler Vibrometer is used to obtain the three components of surface displacements/velocities of the accessible face of the flange of the T-joint. The waves are launched by a piezo ceramic wafer bonded on to the back surface of the flange. What is novel in the proposed method is that the location of any change in material/geometric properties can be traced by computing a frequency domain power flow along a scan line. The scan line can be chosen over a grid either during scan or during post-processing of the scan data off-line. The proposed technique eliminates the necessity of baseline data and disassembly of structure for structural interrogation.

  10. Laser doppler velocimeter system for subsonic jet mixer nozzle testing at the NASA Lewis Aeroacoustic Propulsion Lab

    NASA Technical Reports Server (NTRS)

    Podboy, Gary G.; Bridges, James E.; Saiyed, Naseem H.; Krupar, Martin J.

    1995-01-01

    A laser Doppler velocimeter (LDV) system developed for the Aeroacoustic Propulsion Laboratory (APL) at the NASA Lewis Research Center is described. This system was developed to acquire detailed flow field data which could be used to quantify the effectiveness of internal exhaust gas mixers (IEGM's) and to verify and calibrate computational codes. The LDV was used as an orthogonal, three component system to measure the flow field downstream of the exit of a series of IEGM's and a reference axisymmetric splitter configuration. The LDV system was also used as a one component system to measure the internal axial flow within the nozzle tailpipe downstream of the mixers. These IEGM's were designed for low-bypass ratio turbofan engines. The data were obtained at a simulated low flight speed, high-power operating condition. The optical, seeding, and data acquisition systems of the LDV are described in detail. Sample flow field measurements are provided to illustrate the capabilities of the system at the time of this test, which represented the first use of LDV at the APL. A discussion of planned improvements to the LDV is also included.

  11. Laser Doppler velocimetry measurement at a hard-to-reach intake port of a two-stroke engine

    NASA Astrophysics Data System (ADS)

    Chehroudi, B.; Schuh, D.

    To understand better the complex scavenging process in ported two-stroke engines, optical set-ups were designed for velocity measurements at the exit of an intake port of a motoring and firing single-cylinder propane-fueled two-stroke engine by laser Doppler velocimetry. The radial velocity component was measured at the center of one port at engine speeds of 600, 900, and 1200 rpm. Laser beams entered the engine from the top through a quartz window and the light scattered by the seed particles was collected at 90° through the exhaust ports and a side window. The noise produced by the piston head was analyzed and separated from the signal generated by the seed particles. Analysis of the results from this engine showed that, in general, differences in both magnitude and the shape of the plotted results were observed when the engine was firing. A backflow into the intake system was observed at 600 rpm; this backflow decreased in strength, shifted in crank angle at 900 rpm, and eventually was eliminated at an engine speed of 1200 rpm.

  12. Investigations of unsteady flow in the draft tube of the pump- turbine model using laser Doppler anemometry

    NASA Astrophysics Data System (ADS)

    Kaznacheev, A.; Kuznetsov, I.

    2014-03-01

    The measurements and video observation of unsteady flow in the draft tube cone of the pump-turbine model were conducted in the Laboratory of Water Turbines, property of OJSC "Power machines" - "LMZ". The prototype head was about 250 m. The experiments were performed for the turbine mode of operation. Measurements were taken for the unit speed value n11 corresponding to rated head in the generating mode of operation, for a wide range of guide vanes openings at loads ranging from partial to maximum value. The researches of the velocity field in function of the Thoma number were carried out in some operating conditions. The mean values and RMS deviations of the velocity components were the results of laser measurements. The curves of the intensity of the vortex versus the guide vane opening and the Thoma number were plotted. The energy velocity spectra were presented for the points at which the most pronounced frequency precession of the helical axial vortex was observed. Video recording and laser Doppler anemometry were made in the operating conditions of the developed cavitation. Based on the results of video observations and energy spectra obtained via LDA, vortex frequencies were determined i.e. the frequencies of the vortex precession under the runner in the draft tube cone.

  13. A simulation environment for assisting system design of coherent laser doppler wind sensor for active wind turbine pitch control

    NASA Astrophysics Data System (ADS)

    Shinohara, Leilei; Pham Tran, Tuan Anh; Beuth, Thorsten; Umesh Babu, Harsha; Heussner, Nico; Bogatscher, Siegwart; Danilova, Svetlana; Stork, Wilhelm

    2013-05-01

    In order to assist a system design of laser coherent Doppler wind sensor for active pitch control of wind turbine systems (WTS), we developed a numerical simulation environment for modeling and simulation of the sensor system. In this paper we present this simulation concept. In previous works, we have shown the general idea and the possibility of using a low cost coherent laser Doppler wind sensing system for an active pitch control of WTS in order to achieve a reduced mechanical stress, increase the WTS lifetime and therefore reduce the electricity price from wind energy. Such a system is based on a 1.55μm Continuous-Wave (CW) laser plus an erbium-doped fiber amplifier (EDFA) with an output power of 1W. Within this system, an optical coherent detection method is chosen for the Doppler frequency measurement in megahertz range. A comparatively low cost short coherent length laser with a fiber delay line is used for achieving a multiple range measurement. In this paper, we show the current results on the improvement of our simulation by applying a Monte Carlo random generation method for positioning the random particles in atmosphere and extend the simulation to the entire beam penetrated space by introducing a cylindrical co-ordinate concept and meshing the entire volume into small elements in order to achieve a faster calculation and gain more realistic simulation result. In addition, by applying different atmospheric parameters, such as particle sizes and distributions, we can simulate different weather and wind situations.

  14. Simultaneous recording of fingertip skin blood flow changes by multiprobe laser Doppler flowmetry and frequency-corrected thermal clearance.

    PubMed

    Raamat, Rein; Jagomägi, Kersti; Kingisepp, Peet

    2002-09-01

    We compared the results of skin blood flow (SBF) measurements, obtained simultaneously in adjacent fingertips by laser Doppler flowmetry (LDF) and thermal clearance (TC) probes, having approximately the same spatial and temporal characteristics. Experiments were performed in nine healthy volunteers during rest at room temperature (26-28 degrees C). A time resolution equal to about a second was achieved by speeding up the response of the thermal measurement circuit by applying the computer simulation software of the MATLAB package. The comparison revealed that the frequency-corrected TC signal correlated well with the multiprobe LDF signal (median correlation coefficient = 0.90, range = 0.84 to 0.96). At the same time the individual slope values of the regression equation ranged from 0.58 to 1.61, revealing the difficulties encountered in obtaining the invariant scaling factor between the TC and LDF measurements. The relationship between the frequency-corrected TC signal and the multiprobe LDF signal was found to be linear in the range of SBF changes of about three- to fourfold. In the case of larger fluctuations in SBF, excessive acceleration at high SBF rates was noted. PMID:12204645

  15. Velocity gradients in spatially resolved laser Doppler flowmetry and dynamic light scattering with confocal and coherence gating.

    PubMed

    Uribe-Patarroyo, Néstor; Bouma, Brett E

    2016-08-01

    Dynamic light scattering (DLS) is widely used to characterize diffusive motion to obtain precise information on colloidal suspensions by calculating the autocorrelation function of the signal from a heterodyne optical system. DLS can also be used to determine the flow velocity field in systems that exhibit mass transport by incorporating the effects of the deterministic motion of scatterers on the autocorrelation function, a technique commonly known as laser Doppler flowmetry. DLS measurements can be localized with confocal and coherence gating techniques such as confocal microscopy and optical coherence tomography, thereby enabling the determination of the spatially resolved velocity field in three dimensions. It has been thought that spatially resolved DLS can determine the axial velocity as well as the lateral speed in a single measurement. We demonstrate, however, that gradients in the axial velocity of scatterers exert a fundamental influence on the autocorrelation function even in well-behaved, nonturbulent flow. By obtaining the explicit functional relation between axial-velocity gradients and the autocorrelation function, we show that the velocity field and its derivatives are intimately related and their contributions cannot be separated. Therefore, a single DLS measurement cannot univocally determine the velocity field. Our extended theoretical model was found to be in good agreement with experimental measurements. PMID:27627357

  16. Multi-channel laser Doppler velocimetry using a two-dimensional optical fiber array for obtaining instantaneous velocity distribution characteristics

    NASA Astrophysics Data System (ADS)

    Kyoden, Tomoaki; Yasue, Youichi; Ishida, Hiroki; Akiguchi, Shunsuke; Andoh, Tsugunobu; Takada, Yogo; Teranishi, Tsunenobu; Hachiga, Tadashi

    2015-01-01

    A laser Doppler velocimeter (LDV) has been developed that is capable of performing two-dimensional (2D) cross-sectional measurements. It employs two horizontal laser light sheets that intersect at an angle of 13.3°. Since the intersection region is thin, it can be used to approximately determine the 2D flow field. An 8 × 8 array of optical fibers is used to simultaneously measure Doppler frequencies at 64 points. Experiments were conducted to assess the performance of the LDV, and it was found to be capable of obtaining spatial and temporal velocity information at multiple points in a flow field. The technique is fast, noninvasive, and accurate over long sampling periods. Furthermore, its applicability to an actual flow field was confirmed by measuring the temporal velocity distribution of a pulsatile flow in a rectangular flow channel with an obstruction. The proposed device is thus a useful, compact optical instrument for conducting simultaneous 2D cross-sectional multipoint measurements.

  17. Detection of Site-Specific Blood Flow Variation in Humans during Running by a Wearable Laser Doppler Flowmeter.

    PubMed

    Iwasaki, Wataru; Nogami, Hirofumi; Takeuchi, Satoshi; Furue, Masutaka; Higurashi, Eiji; Sawada, Renshi

    2015-01-01

    Wearable wireless physiological sensors are helpful for monitoring and maintaining human health. Blood flow contains abundant physiological information but it is hard to measure blood flow during exercise using conventional blood flowmeters because of their size, weight, and use of optic fibers. To resolve these disadvantages, we previously developed a micro integrated laser Doppler blood flowmeter using microelectromechanical systems technology. This micro blood flowmeter is wearable and capable of stable measurement signals even during movement. Therefore, we attempted to measure skin blood flow at the forehead, fingertip, and earlobe of seven young men while running as a pilot experiment to extend the utility of the micro blood flowmeter. We measured blood flow in each subject at velocities of 6, 8, and 10 km/h. We succeeded in obtaining stable measurements of blood flow, with few motion artifacts, using the micro blood flowmeter, and the pulse wave signal and motion artifacts were clearly separated by conducting frequency analysis. Furthermore, the results showed that the extent of the changes in blood flow depended on the intensity of exercise as well as previous work with an ergometer. Thus, we demonstrated the capability of this wearable blood flow sensor for measurement during exercise. PMID:26445047

  18. Velocity gradients in spatially-resolved laser Doppler flowmetry and dynamic light scattering with confocal and coherence gating

    PubMed Central

    Uribe-Patarroyo, Néstor; Bouma, Brett E.

    2016-01-01

    Dynamic light scattering (DLS) is widely used to characterize diffusive motion to obtain precise information on colloidal suspensions by calculating the autocorrelation function of the signal from a heterodyne optical system. DLS can also be used to determine the flow velocity field in systems that exhibit mass transport by incorporating the effects of the deterministic motion of scatterers on the autocorrelation function, a technique commonly known as laser Doppler flowmetry. DLS measurements can be localized with confocal and coherence gating techniques such as confocal microscopy and optical coherence tomography, thereby enabling the determination of the spatially-resolved velocity field in three dimensions. It has been thought that spatially-resolved DLS can determine the axial velocity as well as the lateral speed in a single measurement. We demonstrate, however, that gradients in the axial velocity of scatterers exert a fundamental influence on the autocorrelation function even in well-behaved, non-turbulent flow. By obtaining the explicit functional relation between axial-velocity gradients and the autocorrelation function, we show that the velocity field and its derivatives are intimately related and their contributions cannot be separated. Therefore, a single DLS measurement cannot univocally determine the velocity field. Our extended theoretical model was found to be in good agreement with experimental measurements. PMID:27627357

  19. Detection of Site-Specific Blood Flow Variation in Humans during Running by a Wearable Laser Doppler Flowmeter

    PubMed Central

    Iwasaki, Wataru; Nogami, Hirofumi; Takeuchi, Satoshi; Furue, Masutaka; Higurashi, Eiji; Sawada, Renshi

    2015-01-01

    Wearable wireless physiological sensors are helpful for monitoring and maintaining human health. Blood flow contains abundant physiological information but it is hard to measure blood flow during exercise using conventional blood flowmeters because of their size, weight, and use of optic fibers. To resolve these disadvantages, we previously developed a micro integrated laser Doppler blood flowmeter using microelectromechanical systems technology. This micro blood flowmeter is wearable and capable of stable measurement signals even during movement. Therefore, we attempted to measure skin blood flow at the forehead, fingertip, and earlobe of seven young men while running as a pilot experiment to extend the utility of the micro blood flowmeter. We measured blood flow in each subject at velocities of 6, 8, and 10 km/h. We succeeded in obtaining stable measurements of blood flow, with few motion artifacts, using the micro blood flowmeter, and the pulse wave signal and motion artifacts were clearly separated by conducting frequency analysis. Furthermore, the results showed that the extent of the changes in blood flow depended on the intensity of exercise as well as previous work with an ergometer. Thus, we demonstrated the capability of this wearable blood flow sensor for measurement during exercise. PMID:26445047

  20. Errors in measurement of three-dimensional motions of the stapes using a laser Doppler vibrometer system.

    PubMed

    Sim, Jae Hoon; Lauxmann, Michael; Chatzimichalis, Michail; Röösli, Christof; Eiber, Albrecht; Huber, Alexander M

    2010-12-01

    Previous studies have suggested complex modes of physiological stapes motions based upon various measurements. The goal of this study was to analyze the detailed errors in measurement of the complex stapes motions using laser Doppler vibrometer (LDV) systems, which are highly sensitive to the stimulation intensity and the exact angulations of the stapes. Stapes motions were measured with acoustic stimuli as well as mechanical stimuli using a custom-made three-axis piezoelectric actuator, and errors in the motion components were analyzed. The ratio of error in each motion component was reduced by increasing the magnitude of the stimuli, but the improvement was limited when the motion component was small relative to other components. This problem was solved with an improved reflectivity on the measurement surface. Errors in estimating the position of the stapes also caused errors on the coordinates of the measurement points and the laser beam direction relative to the stapes footplate, thus producing errors in the 3-D motion components. This effect was small when the position error of the stapes footplate did not exceed 5 degrees.