Sample records for fully equivalent global

  1. Bonabeau model on a fully connected graph

    NASA Astrophysics Data System (ADS)

    Malarz, K.; Stauffer, D.; Kułakowski, K.

    2006-03-01

    Numerical simulations are reported on the Bonabeau model on a fully connected graph, where spatial degrees of freedom are absent. The control parameter is the memory factor f. The phase transition is observed at the dispersion of the agents power hi. The critical value fC shows a hysteretic behavior with respect to the initial distribution of hi. fC decreases with the system size; this decrease can be compensated by a greater number of fights between a global reduction of the distribution width of hi. The latter step is equivalent to a partial forgetting.

  2. A fully redundant double difference algorithm for obtaining minimum variance estimates from GPS observations

    NASA Technical Reports Server (NTRS)

    Melbourne, William G.

    1986-01-01

    In double differencing a regression system obtained from concurrent Global Positioning System (GPS) observation sequences, one either undersamples the system to avoid introducing colored measurement statistics, or one fully samples the system incurring the resulting non-diagonal covariance matrix for the differenced measurement errors. A suboptimal estimation result will be obtained in the undersampling case and will also be obtained in the fully sampled case unless the color noise statistics are taken into account. The latter approach requires a least squares weighting matrix derived from inversion of a non-diagonal covariance matrix for the differenced measurement errors instead of inversion of the customary diagonal one associated with white noise processes. Presented is the so-called fully redundant double differencing algorithm for generating a weighted double differenced regression system that yields equivalent estimation results, but features for certain cases a diagonal weighting matrix even though the differenced measurement error statistics are highly colored.

  3. Quantification and scaling of multipartite entanglement in continuous variable systems.

    PubMed

    Adesso, Gerardo; Serafini, Alessio; Illuminati, Fabrizio

    2004-11-26

    We present a theoretical method to determine the multipartite entanglement between different partitions of multimode, fully or partially symmetric Gaussian states of continuous variable systems. For such states, we determine the exact expression of the logarithmic negativity and show that it coincides with that of equivalent two-mode Gaussian states. Exploiting this reduction, we demonstrate the scaling of the multipartite entanglement with the number of modes and its reliable experimental estimate by direct measurements of the global and local purities.

  4. Decomposed direct matrix inversion for fast non-cartesian SENSE reconstructions.

    PubMed

    Qian, Yongxian; Zhang, Zhenghui; Wang, Yi; Boada, Fernando E

    2006-08-01

    A new k-space direct matrix inversion (DMI) method is proposed here to accelerate non-Cartesian SENSE reconstructions. In this method a global k-space matrix equation is established on basic MRI principles, and the inverse of the global encoding matrix is found from a set of local matrix equations by taking advantage of the small extension of k-space coil maps. The DMI algorithm's efficiency is achieved by reloading the precalculated global inverse when the coil maps and trajectories remain unchanged, such as in dynamic studies. Phantom and human subject experiments were performed on a 1.5T scanner with a standard four-channel phased-array cardiac coil. Interleaved spiral trajectories were used to collect fully sampled and undersampled 3D raw data. The equivalence of the global k-space matrix equation to its image-space version, was verified via conjugate gradient (CG) iterative algorithms on a 2x undersampled phantom and numerical-model data sets. When applied to the 2x undersampled phantom and human-subject raw data, the decomposed DMI method produced images with small errors (< or = 3.9%) relative to the reference images obtained from the fully-sampled data, at a rate of 2 s per slice (excluding 4 min for precalculating the global inverse at an image size of 256 x 256). The DMI method may be useful for noise evaluations in parallel coil designs, dynamic MRI, and 3D sodium MRI with fixed coils and trajectories. Copyright 2006 Wiley-Liss, Inc.

  5. Increasing global agricultural production by reducing ozone damages via methane emission controls and ozone-resistant cultivar selection

    PubMed Central

    Avnery, Shiri; Mauzerall, Denise L; Fiore, Arlene M

    2013-01-01

    Meeting the projected 50% increase in global grain demand by 2030 without further environmental degradation poses a major challenge for agricultural production. Because surface ozone (O3) has a significant negative impact on crop yields, one way to increase future production is to reduce O3-induced agricultural losses. We present two strategies whereby O3 damage to crops may be reduced. We first examine the potential benefits of an O3 mitigation strategy motivated by climate change goals: gradual emission reductions of methane (CH4), an important greenhouse gas and tropospheric O3 precursor that has not yet been targeted for O3 pollution abatement. Our second strategy focuses on adapting crops to O3 exposure by selecting cultivars with demonstrated O3 resistance. We find that the CH4 reductions considered would increase global production of soybean, maize, and wheat by 23–102 Mt in 2030 – the equivalent of a ∼2–8% increase in year 2000 production worth $3.5–15 billion worldwide (USD2000), increasing the cost effectiveness of this CH4 mitigation policy. Choosing crop varieties with O3 resistance (relative to median-sensitivity cultivars) could improve global agricultural production in 2030 by over 140 Mt, the equivalent of a 12% increase in 2000 production worth ∼$22 billion. Benefits are dominated by improvements for wheat in South Asia, where O3-induced crop losses would otherwise be severe. Combining the two strategies generates benefits that are less than fully additive, given the nature of O3 effects on crops. Our results demonstrate the significant potential to sustainably improve global agricultural production by decreasing O3-induced reductions in crop yields. PMID:23504903

  6. Experimental investigation on ignition schemes of partially covered cavities in a supersonic flow

    NASA Astrophysics Data System (ADS)

    Cai, Zun; Sun, Mingbo; Wang, Hongbo; Wang, Zhenguo

    2016-04-01

    In this study, ignition schemes of the partially covered cavity in a scramjet combustor were investigated under inflow conditions of Ma=2.1 with stagnation pressure P0=0.7 Mpa and stagnation temperature T0=947 K. It reveals that the ignition scheme of the partially covered cavity has a great impact on the ignition and flame stabilization process. There always exists an optimized global equivalence ratio of a fixed ignition scheme, and the optimized global equivalence ratio of ignition in the partially covered cavity is lower than that of the uncovered cavity. For tandem dual-cavities, ignition in the partially covered cavity could be enhanced with the optimization of global equivalence ratio. However, ignition in the partially covered cavity would be exacerbated with further increasing the global equivalence ratio. The global equivalence ratio and the jet penetration height have a strong coupling with the combustion flow-field. For multi-cavities, it is assured that fuel injection on the opposite side could hardly be ignited after ignition in the partially covered cavity even with the optimized global equivalence ratio. It is possible to realize ignition enhancement in the partially covered cavity with the optimization of global equivalence ratio, but it is not beneficial for thrust increment during the steady combustion process.

  7. A novel fully-humanised 3D skin equivalent to model early melanoma invasion

    PubMed Central

    Hill, David S; Robinson, Neil D P; Caley, Matthew P; Chen, Mei; O’Toole, Edel A; Armstrong, Jane L; Przyborski, Stefan; Lovat, Penny E

    2015-01-01

    Metastatic melanoma remains incurable, emphasising the acute need for improved research models to investigate the underlying biological mechanisms mediating tumour invasion and metastasis, and to develop more effective targeted therapies to improve clinical outcome. Available animal models of melanoma do not accurately reflect human disease and current in vitro human skin equivalent models incorporating melanoma cells are not fully representative of the human skin microenvironment. We have developed a robust and reproducible, fully-humanised 3D skin equivalent comprising a stratified, terminally differentiated epidermis and a dermal compartment consisting of fibroblast-generated extracellular matrix. Melanoma cells incorporated into the epidermis were able to invade through the basement membrane and into the dermis, mirroring early tumour invasion in vivo. Comparison of our novel 3D melanoma skin equivalent with melanoma in situ and metastatic melanoma indicates this model accurately recreates features of disease pathology, making it a physiologically representative model of early radial and vertical growth phase melanoma invasion. PMID:26330548

  8. Assessing the Global Climate Response to Freshwater Forcing from the Antarctic Ice Sheet Under Future Climate Scenarios

    NASA Astrophysics Data System (ADS)

    Rogstad, S.; Condron, A.; DeConto, R.; Pollard, D.

    2017-12-01

    Observational evidence indicates that the West Antarctic Ice Sheet (WAIS) is losing mass at an accelerating rate. Impacts to global climate resulting from changing ocean circulation patterns due to increased freshwater runoff from Antarctica in the future could have significant implications for global heat transport, but to-date this topic has not been investigated using complex numerical models with realistic freshwater forcing. Here, we present results from a high resolution fully coupled ocean-atmosphere model (CESM 1.2) forced with runoff from Antarctica prescribed from a high resolution regional ice sheet-ice shelf model. Results from the regional simulations indicate a potential freshwater contribution from Antarctica of up to 1 m equivalent sea level rise by the end of the century under RCP 8.5 indicating that a substantial input of freshwater into the Southern Ocean is possible. Our high resolution global simulations were performed under IPCC future climate scenarios RCP 4.5 and 8.5. We will present results showing the impact of WAIS collapse on global ocean circulation, sea ice, air temperature, and salinity in order to assess the potential for abrupt climate change triggered by WAIS collapse.

  9. The AMSR2 Satellite-based Microwave Snow Algorithm (SMSA) to estimate regional to global snow depth and snow water equivalent

    NASA Astrophysics Data System (ADS)

    Kelly, R. E. J.; Saberi, N.; Li, Q.

    2017-12-01

    With moderate to high spatial resolution (<1 km) regional to global snow water equivalent (SWE) observation approaches yet to be fully scoped and developed, the long-term satellite passive microwave record remains an important tool for cryosphere-climate diagnostics. A new satellite microwave remote sensing approach is described for estimating snow depth (SD) and snow water equivalent (SWE). The algorithm, called the Satellite-based Microwave Snow Algorithm (SMSA), uses Advanced Microwave Scanning Radiometer - 2 (AMSR2) observations aboard the Global Change Observation Mission - Water mission launched by the Japan Aerospace Exploration Agency in 2012. The approach is unique since it leverages observed brightness temperatures (Tb) with static ancillary data to parameterize a physically-based retrieval without requiring parameter constraints from in situ snow depth observations or historical snow depth climatology. After screening snow from non-snow surface targets (water bodies [including freeze/thaw state], rainfall, high altitude plateau regions [e.g. Tibetan plateau]), moderate and shallow snow depths are estimated by minimizing the difference between Dense Media Radiative Transfer model estimates (Tsang et al., 2000; Picard et al., 2011) and AMSR2 Tb observations to retrieve SWE and SD. Parameterization of the model combines a parsimonious snow grain size and density approach originally developed by Kelly et al. (2003). Evaluation of the SMSA performance is achieved using in situ snow depth data from a variety of standard and experiment data sources. Results presented from winter seasons 2012-13 to 2016-17 illustrate the improved performance of the new approach in comparison with the baseline AMSR2 algorithm estimates and approach the performance of the model assimilation-based approach of GlobSnow. Given the variation in estimation power of SWE by different land surface/climate models and selected satellite-derived passive microwave approaches, SMSA provides SWE estimates that are independent of real or near real-time in situ and model data.

  10. Driven by excess? Climatic implications of new global mapping of near-surface water-equivalent hydrogen on Mars

    NASA Astrophysics Data System (ADS)

    Pathare, Asmin V.; Feldman, William C.; Prettyman, Thomas H.; Maurice, Sylvestre

    2018-02-01

    We present improved Mars Odyssey Neutron Spectrometer (MONS) maps of near-surface Water-Equivalent Hydrogen (WEH) on Mars that have intriguing implications for the global distribution of "excess" ice, which occurs when the mass fraction of water ice exceeds the threshold amount needed to saturate the pore volume in normal soils. We have refined the crossover technique of Feldman et al. (2011) by using spatial deconvolution and Gaussian weighting to create the first globally self-consistent map of WEH. At low latitudes, our new maps indicate that WEH exceeds 15% in several near-equatorial regions, such as Arabia Terra, which has important implications for the types of hydrated minerals present at low latitudes. At high latitudes, we demonstrate that the disparate MONS and Phoenix Robotic Arm (RA) observations of near surface WEH can be reconciled by a three-layer model incorporating dry soil over fully saturated pore ice over pure excess ice: such a three-layer model can also potentially explain the strong anticorrelation of subsurface ice content and ice table depth observed at high latitudes. At moderate latitudes, we show that the distribution of recently formed impact craters is also consistent with our latest MONS results, as both the shallowest ice-exposing crater and deepest non-ice-exposing crater at each impact site are in good agreement with our predictions of near-surface WEH. Overall, we find that our new mapping is consistent with the widespread presence at mid-to-high Martian latitudes of recently deposited shallow excess ice reservoirs that are not yet in equilibrium with the atmosphere.

  11. Expanded algal cultivation can reverse key planetary boundary transgressions.

    PubMed

    Calahan, Dean; Osenbaugh, Edward; Adey, Walter

    2018-02-01

    Humanity is degrading multiple ecosystem services, potentially irreversibly. Two of the most important human impacts are excess agricultural nutrient loading in our fresh and estuarine waters and excess carbon dioxide in our oceans and atmosphere. Large-scale global intervention is required to slow, halt, and eventually reverse these stresses. Cultivating attached polyculture algae within controlled open-field photobioreactors is a practical technique for exploiting the ubiquity and high primary productivity of algae to capture and recycle the pollutants driving humanity into unsafe regimes of biogeochemical cycling, ocean acidification, and global warming. Expanded globally and appropriately distributed, algal cultivation is capable of removing excess nutrients from global environments, while additionally sequestering appreciable excess carbon. While obviously a major capital and operational investment, such a project is comparable in magnitude to the construction and maintenance of the global road transportation network. Beyond direct amelioration of critical threats, expanded algal cultivation would produce a major new commodity flow of biomass, potentially useful either as a valuable organic commodity itself, or used to reduce the scale of the problem by improving soils, slowing or reversing the loss of arable land. A 100 year project to expand algal cultivation to completely recycle excess global agricultural N and P would, when fully operational, require gross global expenses no greater than $2.3 × 10 12 yr -1 , (3.0% of the 2016 global domestic product) and less than 1.9 × 10 7 ha (4.7 × 10 7 ac), 0.38% of the land area used globally to grow food. The biomass generated embodies renewable energy equivalent to 2.8% of global primary energy production.

  12. 78 FR 4478 - New Postal Product

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  13. On the Use of Equivalent Linearization for High-Cycle Fatigue Analysis of Geometrically Nonlinear Structures

    NASA Technical Reports Server (NTRS)

    Rizzi, Stephen A.

    2003-01-01

    The use of stress predictions from equivalent linearization analyses in the computation of high-cycle fatigue life is examined. Stresses so obtained differ in behavior from the fully nonlinear analysis in both spectral shape and amplitude. Consequently, fatigue life predictions made using this data will be affected. Comparisons of fatigue life predictions based upon the stress response obtained from equivalent linear and numerical simulation analyses are made to determine the range over which the equivalent linear analysis is applicable.

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  15. Mesh Deformation Based on Fully Stressed Design: The Method and Two-Dimensional Examples

    NASA Technical Reports Server (NTRS)

    Hsu, Su-Yuen; Chang, Chau-Lyan

    2007-01-01

    Mesh deformation in response to redefined boundary geometry is a frequently encountered task in shape optimization and analysis of fluid-structure interaction. We propose a simple and concise method for deforming meshes defined with three-node triangular or four-node tetrahedral elements. The mesh deformation method is suitable for large boundary movement. The approach requires two consecutive linear elastic finite-element analyses of an isotropic continuum using a prescribed displacement at the mesh boundaries. The first analysis is performed with homogeneous elastic property and the second with inhomogeneous elastic property. The fully stressed design is employed with a vanishing Poisson s ratio and a proposed form of equivalent strain (modified Tresca equivalent strain) to calculate, from the strain result of the first analysis, the element-specific Young s modulus for the second analysis. The theoretical aspect of the proposed method, its convenient numerical implementation using a typical linear elastic finite-element code in conjunction with very minor extra coding for data processing, and results for examples of large deformation of two-dimensional meshes are presented in this paper. KEY WORDS: Mesh deformation, shape optimization, fluid-structure interaction, fully stressed design, finite-element analysis, linear elasticity, strain failure, equivalent strain, Tresca failure criterion

  16. SMAP L-Band Microwave Radiometer: Instrument Design and First Year on Orbit

    NASA Technical Reports Server (NTRS)

    Piepmeier, Jeffrey R.; Focardi, Paolo; Horgan, Kevin; Knuble, Joseph; Ehsan, Negar; Lucey, Jared; Brambora, Clifford; Brown, Paula R.; Hoffman, Pamela J.; French, Richard T.; hide

    2017-01-01

    The Soil Moisture Active Passive (SMAP) L-band microwave radiometer is a conical scanning instrument designed to measure soil moisture with 4 percent volumetric accuracy at 40-kilometer spatial resolution. SMAP is NASA's first Earth Systematic Mission developed in response to its first Earth science decadal survey. Here, the design is reviewed and the results of its first year on orbit are presented. Unique features of radiometer include a large 6-meter rotating reflector, fully polarimetric radiometer receiver with internal calibration, and radio-frequency interference detection and filtering hardware. The radiometer electronics are thermally controlled to achieve good radiometric stability. Analyses of on-orbit results indicate the electrical and thermal characteristics of the electronics and internal calibration sources are very stable and promote excellent gain stability. Radiometer NEdT (Noise Equivalent differential Temperature) less than 1 degree Kelvin for 17-millisecond samples. The gain spectrum exhibits low noise at frequencies greater than 1 megahertz and 1 divided by f (pink) noise rising at longer time scales fully captured by the internal calibration scheme. Results from sky observations and global swath imagery of all four Stokes antenna temperatures indicate the instrument is operating as expected.

  17. Partially premixed prevalorized kerosene spray combustion in turbulent flow

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Chrigui, M.; Ahmadi, W.; Sadiki, A.

    2010-04-15

    A detailed numerical simulation of kerosene spray combustion was carried out on a partially premixed, prevaporized, three-dimensional configuration. The focus was on the flame temperature profile dependency on the length of the pre-vaporization zone. The results were analyzed and compared to experimental data. A fundamental study was performed to observe the temperature variation and flame flashback. Changes were made to the droplet diameter, kerosene flammability limits, a combustion model parameter and the location of the combustion initialization. Investigations were performed for atmospheric pressure, inlet air temperature of 90 C and a global equivalence ratio of 0.7. The simulations were carriedmore » out using the Eulerian Lagrangian procedure under a fully two-way coupling. The Bray-Moss-Libby model was adjusted to account for the partially premixed combustion. (author)« less

  18. Inhibition accumulates over time at multiple processing levels in bilingual language control.

    PubMed

    Kleinman, Daniel; Gollan, Tamar H

    2018-04-01

    It is commonly assumed that bilinguals enable production in their nondominant language by inhibiting their dominant language temporarily, fully lifting inhibition to switch back. In a re-analysis of data from 416 Spanish-English bilinguals who repeatedly named a small set of pictures while switching languages in response to cues, we separated trials into different types that revealed three cumulative effects. Bilinguals named each picture (a) faster for every time they had previously named that same picture in the same language, an asymmetric repetition priming effect that was greater in their nondominant language, and (b) more slowly for every time they had previously named that same picture in the other language, an effect that was equivalent across languages and implies symmetric lateral inhibition between translation equivalents. Additionally, (c) bilinguals named pictures in the dominant language more slowly for every time they had previously named unrelated pictures in the nondominant language, exhibiting asymmetric language-wide global inhibition. These mechanisms dynamically alter the balances of activation between languages and between lemmas, providing evidence for an oft-assumed but seldom demonstrated key mechanism of bilingual control (competition between translations), resolving the mystery of why reversed language dominance sometimes emerges (the combined forces of asymmetrical effects emerge over time in mixed-language blocks), and also explaining other longer-lasting effects (block order). Key signatures of bilingual control can depend on seemingly trivial methodological details (e.g., the number of trials in a block) because inhibition is applied cumulatively at both local and global levels, persisting long after each individual act of selection. Copyright © 2018 Elsevier B.V. All rights reserved.

  19. Comparison of physically- and economically-based CO2-equivalences for methane

    NASA Astrophysics Data System (ADS)

    Boucher, O.

    2012-01-01

    There is a controversy on the role methane (and other short-lived species) should play in climate mitigation policies and no consensus on what an optimal methane CO2-equivalence should be. We revisit this question by discussing the relative merits of physically-based (i.e. Global Warming Potential or GWP and Global Temperature change Potential or GTP) and socio-economically-based climate metrics. To this effect we use a simplified Global Damage Potential (GDP) that was introduced by earlier authors and investigate the uncertainties in the methane CO2-equivalence that arise from physical and socio-economic factors. The median value of the methane GDP comes out very close to the widely used methane 100-year GWP because of various compensating effects. However there is a large spread in possible methane CO2-equivalences (1-99% interval: 10.0-42.5; 5-95% interval: 12.5-38.0) that is essentially due to the choice in some socio-economic parameters (i.e. the damage cost function and the discount rate). The methane 100-year GTP falls outside these ranges. It is legitimate to increase the methane CO2-equivalence in the future as global warming unfolds. While changes in biogeochemical cycles and radiative efficiencies cause some small changes to physically-based metrics, a systematic increase in the methane CO2-equivalence can only be achieved by some ad-hoc shortening of the time horizon. In contrast using a convex damage cost function provides a natural increase in the methane CO2-equivalence for the socio-economically-based metrics. We also show that a methane CO2-equivalence based on a pulse emission is sufficient to inform multi-year climate policies and emissions reductions as long as there is some degree of visibility on CO2 prices and CO2-equivalences.

  20. Green-house gas mitigation capacity of a small scale rural biogas plant calculations for Bangladesh through a general life cycle assessment.

    PubMed

    Rahman, Khondokar M; Melville, Lynsey; Fulford, David; Huq, Sm Imamul

    2017-10-01

    Calculations towards determining the greenhouse gas mitigation capacity of a small-scale biogas plant (3.2 m 3 plant) using cow dung in Bangladesh are presented. A general life cycle assessment was used, evaluating key parameters (biogas, methane, construction materials and feedstock demands) to determine the net environmental impact. The global warming potential saving through the use of biogas as a cooking fuel is reduced from 0.40 kg CO 2 equivalent to 0.064 kg CO 2 equivalent per kilogram of dung. Biomethane used for cooking can contribute towards mitigation of global warming. Prior to utilisation of the global warming potential of methane (from 3.2 m 3 biogas plant), the global warming potential is 13 t of carbon dioxide equivalent. This reduced to 2 t as a result of complete combustion of methane. The global warming potential saving of a bioenergy plant across a 20-year life cycle is 217 t of carbon dioxide equivalent, which is 11 t per year. The global warming potential of the resultant digestate is zero and from construction materials is less than 1% of total global warming potential. When the biogas is used as a fuel for cooking, the global warming potential will reduce by 83% compare with the traditional wood biomass cooking system. The total 80 MJ of energy that can be produced from a 3.2 m 3 anaerobic digestion plant would replace 1.9 t of fuel wood or 632 kg of kerosene currently used annually in Bangladesh. The digestate can also be used as a nutrient rich fertiliser substituting more costly inorganic fertilisers, with no global warming potential impact.

  1. Comparison of physically- and economically-based CO2-equivalences for methane

    NASA Astrophysics Data System (ADS)

    Boucher, O.

    2012-05-01

    There is a controversy on the role methane (and other short-lived species) should play in climate mitigation policies, and there is no consensus on what an optimal methane CO2-equivalence should be. We revisit this question by discussing some aspects of physically-based (i.e. global- warming potential or GWP and global temperature change potential or GTP) and socio-economically-based climate metrics. To this effect we use a simplified global damage potential (GDP) that was introduced by earlier authors and investigate the uncertainties in the methane CO2-equivalence that arise from physical and socio-economic factors. The median value of the methane GDP comes out very close to the widely used methane 100-yr GWP because of various compensating effects. However, there is a large spread in possible methane CO2-equivalences from this metric (1-99% interval: 10.0-42.5; 5-95% interval: 12.5-38.0) that is essentially due to the choice in some socio-economic parameters (i.e. the damage cost function and the discount rate). The main factor differentiating the methane 100-yr GTP from the methane 100-yr GWP and the GDP is the fact that the former metric is an end-point metric, whereas the latter are cumulative metrics. There is some rationale for an increase in the methane CO2-equivalence in the future as global warming unfolds, as implied by a convex damage function in the case of the GDP metric. We also show that a methane CO2-equivalence based on a pulse emission is sufficient to inform multi-year climate policies and emissions reductions, as long as there is enough visibility on CO2 prices and CO2-equivalences for the stakeholders.

  2. Formation of Partially and Fully Elaborated Generalized Equivalence Classes

    ERIC Educational Resources Information Center

    Fields, Lanny; Moss, Patricia

    2008-01-01

    Most complex categories observed in real-world settings consist of perceptually disparate stimuli, such as a picture of a person's face, the person's name as written, and the same name as heard, as well as dimensional variants of some or all of these stimuli. The stimuli function as members of a single partially or fully elaborated generalized…

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  10. An open ecosystem engagement strategy through the lens of global food safety

    PubMed Central

    Stacey, Paul; Fons, Garin; Bernardo, Theresa M

    2015-01-01

    The Global Food Safety Partnership (GFSP) is a public/private partnership established through the World Bank to improve food safety systems through a globally coordinated and locally-driven approach. This concept paper aims to establish a framework to help GFSP fully leverage the potential of open models. In preparing this paper the authors spoke to many different GFSP stakeholders who asked questions about open models such as: what is it?what’s in it for me?why use an open rather than a proprietary model?how will open models generate equivalent or greater sustainable revenue streams compared to the current “traditional” approaches?  This last question came up many times with assertions that traditional service providers need to see opportunity for equivalent or greater revenue dollars before they will buy-in. This paper identifies open value propositions for GFSP stakeholders and proposes a framework for creating and structuring that value. Open Educational Resources (OER) were the primary open practice GFSP partners spoke to us about, as they provide a logical entry point for collaboration. Going forward, funders should consider requiring that educational resources and concomitant data resulting from their sponsorship should be open, as a public good. There are, however, many other forms of open practice that bring value to the GFSP. Nine different open strategies and tactics (Appendix A) are described, including: open content (including OER and open courseware), open data, open access (research), open government, open source software, open standards, open policy, open licensing and open hardware. It is recommended that all stakeholders proactively pursue "openness" as an operating principle. This paper presents an overall GFSP Open Ecosystem Engagement Strategy within which specific local case examples can be situated. Two different case examples, China and Colombia, are presented to show both project-based and crowd-sourced, direct-to-public paths through this ecosystem. PMID:26213614

  11. Fair Balance? An Analysis of the Functional Equivalence of Risk and Benefit Information in Prescription Drug Direct-to-Consumer Television Advertising

    ERIC Educational Resources Information Center

    Baird-Harris, Kay

    2009-01-01

    Prescription drug direct-to-consumer advertising (DTCA) has been a subject of controversy in recent years. Though government regulations require equivalent prominence of risks and benefits, there is concern about the ability of consumers with limited health literacy to fully comprehend the risks and benefits associated with drug use. Evaluating…

  12. Effects of language of assessment on the measurement of acculturation: measurement equivalence and cultural frame switching.

    PubMed

    Schwartz, Seth J; Benet-Martínez, Verónica; Knight, George P; Unger, Jennifer B; Zamboanga, Byron L; Des Rosiers, Sabrina E; Stephens, Dionne P; Huang, Shi; Szapocznik, José

    2014-03-01

    The present study used a randomized design, with fully bilingual Hispanic participants from the Miami area, to investigate 2 sets of research questions. First, we sought to ascertain the extent to which measures of acculturation (Hispanic and U.S. practices, values, and identifications) satisfied criteria for linguistic measurement equivalence. Second, we sought to examine whether cultural frame switching would emerge--that is, whether latent acculturation mean scores for U.S. acculturation would be higher among participants randomized to complete measures in English and whether latent acculturation mean scores for Hispanic acculturation would be higher among participants randomized to complete measures in Spanish. A sample of 722 Hispanic students from a Hispanic-serving university participated in the study. Participants were first asked to complete translation tasks to verify that they were fully bilingual. Based on ratings from 2 independent coders, 574 participants (79.5% of the sample) qualified as fully bilingual and were randomized to complete the acculturation measures in either English or Spanish. Theoretically relevant criterion measures--self-esteem, depressive symptoms, and personal identity--were also administered in the randomized language. Measurement equivalence analyses indicated that all of the acculturation measures--Hispanic and U.S. practices, values, and identifications-met criteria for configural, weak/metric, strong/scalar, and convergent validity equivalence. These findings indicate that data generated using acculturation measures can, at least under some conditions, be combined or compared across languages of administration. Few latent mean differences emerged. These results are discussed in terms of the measurement of acculturation in linguistically diverse populations. 2014 APA

  13. Effects of Language of Assessment on the Measurement of Acculturation: Measurement Equivalence and Cultural Frame Switching

    PubMed Central

    Schwartz, Seth J.; Benet-Martínez, Verónica; Knight, George P.; Unger, Jennifer B.; Zamboanga, Byron L.; Des Rosiers, Sabrina E.; Stephens, Dionne; Huang, Shi; Szapocznik, José

    2014-01-01

    The present study used a randomized design, with fully bilingual Hispanic participants from the Miami area, to investigate two sets of research questions. First, we sought to ascertain the extent to which measures of acculturation (heritage and U.S. practices, values, and identifications) satisfied criteria for linguistic measurement equivalence. Second, we sought to examine whether cultural frame switching would emerge – that is, whether latent acculturation mean scores for U.S. acculturation would be higher among participants randomized to complete measures in English, and whether latent acculturation mean scores for Hispanic acculturation would be higher among participants randomized to complete measures in Spanish. A sample of 722 Hispanic students from a Hispanic-serving university participated in the study. Participants were first asked to complete translation tasks to verify that they were fully bilingual. Based on ratings from two independent coders, 574 participants (79.5% of the sample) qualified as fully bilingual and were randomized to complete the acculturation measures in either English or Spanish. Theoretically relevant criterion measures – self-esteem, depressive symptoms, and personal identity – were also administered in the randomized language. Measurement equivalence analyses indicated that all of the acculturation measures – Hispanic and U.S. practices, values, and identifications – met criteria for configural, weak/metric, strong/scalar, and convergent validity equivalence. These findings indicate that data generated using acculturation measures can, at least under some conditions, be combined or compared across languages of administration. Few latent mean differences emerged. These results are discussed in terms of the measurement of acculturation in linguistically diverse populations. PMID:24188146

  14. 75 FR 7296 - New Postal Product

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-18

    ... Equivalent Global Expedited package Services 2 Negotiated Service Agreement and Application for Non-Public... Postal Service believes the instant contract is functionally equivalent to previously submitted GEPS 2... established GEPS 1 as a product, also authorized functionally equivalent agreements to be included within the...

  15. Performance analysis of FET microwave devices by use of extended spectral-element time-domain method

    NASA Astrophysics Data System (ADS)

    Sheng, Yijun; Xu, Kan; Wang, Daoxiang; Chen, Rushan

    2013-05-01

    The extended spectral-element time-domain (SETD) method is employed to analyse field effect transistor (FET) microwave devices. In order to impose the contribution of the FET microwave devices into the electromagnetic simulation, the SETD method is extended by introducing a lumped current term into the vector Helmholtz equation. The change of currents on each lumped component can be expressed by the change of voltage via corresponding models of equivalent circuit. The electric fields around the lumped component must be influenced by the change of voltage on each lumped component, and vice versa. So a global coupling about the EM-circuit can be built directly. The fully explicit solving scheme is maintained in this extended SETD method and the CPU time can be saved spontaneously. Three practical FET microwave devices are analysed in this article. The numerical results demonstrate the ability and accuracy of this method.

  16. In Vitro Hydrodynamic Assessment of a New Transcatheter Heart Valve Concept (the TRISKELE).

    PubMed

    Rahmani, Benyamin; Tzamtzis, Spyros; Sheridan, Rose; Mullen, Michael J; Yap, John; Seifalian, Alexander M; Burriesci, Gaetano

    2017-04-01

    This study presents the in vitro hydrodynamic assessment of the TRISKELE, a new system suitable for transcatheter aortic valve implantation (TAVI), aiming to mitigate the procedural challenges experienced with current technologies. The TRISKELE valve comprises three polymeric leaflet and an adaptive sealing cuff, supported by a novel fully retrievable self-expanding nitinol wire frame. Valve prototypes were manufactured in three sizes of 23, 26, and 29 mm by automated dip-coating of a biostable polymer, and tested in a hydrodynamic bench setup in mock aortic roots of 21, 23, 25, and 27 mm annulus, and compared to two reference valves suitable for equivalent implantation ranges: Edwards SAPIEN XT and Medtronic CoreValve. The TRISKELE valves demonstrated a global hydrodynamic performance comparable or superior to the controls with significant reduction in paravalvular leakage. The TRISKELE valve exhibits enhanced anchoring and improved sealing. The valve is currently under preclinical investigation.

  17. Solving a class of generalized fractional programming problems using the feasibility of linear programs.

    PubMed

    Shen, Peiping; Zhang, Tongli; Wang, Chunfeng

    2017-01-01

    This article presents a new approximation algorithm for globally solving a class of generalized fractional programming problems (P) whose objective functions are defined as an appropriate composition of ratios of affine functions. To solve this problem, the algorithm solves an equivalent optimization problem (Q) via an exploration of a suitably defined nonuniform grid. The main work of the algorithm involves checking the feasibility of linear programs associated with the interesting grid points. It is proved that the proposed algorithm is a fully polynomial time approximation scheme as the ratio terms are fixed in the objective function to problem (P), based on the computational complexity result. In contrast to existing results in literature, the algorithm does not require the assumptions on quasi-concavity or low-rank of the objective function to problem (P). Numerical results are given to illustrate the feasibility and effectiveness of the proposed algorithm.

  18. DNS of turbulent premixed slot flames with mixture inhomogeneity: a study of NOx formation

    NASA Astrophysics Data System (ADS)

    Luca, Stefano; Attili, Antonio; Bisetti, Fabrizio

    2016-11-01

    A set of Direct Numerical Simulations of three-dimensional methane/air lean flames in a spatially developing turbulent slot burner are performed. The flames are in the thin-reaction zone regimes and the jet Reynolds number is 5600. This configuration is of interest since it displays turbulent production by mean shear as in real devices. The gas phase hydrodynamics are modeled with the reactive, unsteady Navier-Stokes equations in the low Mach number limit. Combustion is treated with finite-rate chemistry. The jet is characterized by a non-uniform equivalence ratio at the inlet and varying levels of incomplete premixing for the methane/air mixture are considered. The global equivalence ratio is 0.7 and temperature is 800 K. All simulations are performed at 4 atm. The instantaneous profiles of the mass fractions of methane and air at the inlet are sampled from a set of turbulent channel simulations that provide realistic, fully turbulent fields. The data are analyzed to study the influence of partial premixing on the flame structure. Particular focus is devoted to the assessment of heat release rate fluctuations and NOx formation. In particular, the effects of partial premixing on the production rates for the various pathways to NOx formation are investigated.

  19. Grandfathered, Grandmothered, And ACA-Compliant Health Plans Have Equivalent Premiums.

    PubMed

    Whitmore, Heidi; Gabel, Jon R; Satorius, Jennifer L; Green, Matthew

    2017-02-01

    Many small employers offer employees health plans that are not fully compliant with Affordable Care Act (ACA) provisions such as covering preventive services without cost sharing. These "grandfathered" and "grandmothered" plans accounted for about 65 percent of enrollment in the small-group market in 2014. Premium costs for these and ACA-compliant plans were equivalent. Project HOPE—The People-to-People Health Foundation, Inc.

  20. A quality assurance framework for the fully automated and objective evaluation of image quality in cone-beam computed tomography.

    PubMed

    Steiding, Christian; Kolditz, Daniel; Kalender, Willi A

    2014-03-01

    Thousands of cone-beam computed tomography (CBCT) scanners for vascular, maxillofacial, neurological, and body imaging are in clinical use today, but there is no consensus on uniform acceptance and constancy testing for image quality (IQ) and dose yet. The authors developed a quality assurance (QA) framework for fully automated and time-efficient performance evaluation of these systems. In addition, the dependence of objective Fourier-based IQ metrics on direction and position in 3D volumes was investigated for CBCT. The authors designed a dedicated QA phantom 10 cm in length consisting of five compartments, each with a diameter of 10 cm, and an optional extension ring 16 cm in diameter. A homogeneous section of water-equivalent material allows measuring CT value accuracy, image noise and uniformity, and multidimensional global and local noise power spectra (NPS). For the quantitative determination of 3D high-contrast spatial resolution, the modulation transfer function (MTF) of centrally and peripherally positioned aluminum spheres was computed from edge profiles. Additional in-plane and axial resolution patterns were used to assess resolution qualitatively. The characterization of low-contrast detectability as well as CT value linearity and artifact behavior was tested by utilizing sections with soft-tissue-equivalent and metallic inserts. For an automated QA procedure, a phantom detection algorithm was implemented. All tests used in the dedicated QA program were initially verified in simulation studies and experimentally confirmed on a clinical dental CBCT system. The automated IQ evaluation of volume data sets of the dental CBCT system was achieved with the proposed phantom requiring only one scan for the determination of all desired parameters. Typically, less than 5 min were needed for phantom set-up, scanning, and data analysis. Quantitative evaluation of system performance over time by comparison to previous examinations was also verified. The maximum percentage interscan variation of repeated measurements was less than 4% and 1.7% on average for all investigated quality criteria. The NPS-based image noise differed by less than 5% from the conventional standard deviation approach and spatially selective 10% MTF values were well comparable to subjective results obtained with 3D resolution pattern. Determining only transverse spatial resolution and global noise behavior in the central field of measurement turned out to be insufficient. The proposed framework transfers QA routines employed in conventional CT in an advanced version to CBCT for fully automated and time-efficient evaluation of technical equipment. With the modular phantom design, a routine as well as an expert version for assessing IQ is provided. The QA program can be used for arbitrary CT units to evaluate 3D imaging characteristics automatically.

  1. A quality assurance framework for the fully automated and objective evaluation of image quality in cone-beam computed tomography

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Steiding, Christian; Kolditz, Daniel; Kalender, Willi A., E-mail: willi.kalender@imp.uni-erlangen.de

    Purpose: Thousands of cone-beam computed tomography (CBCT) scanners for vascular, maxillofacial, neurological, and body imaging are in clinical use today, but there is no consensus on uniform acceptance and constancy testing for image quality (IQ) and dose yet. The authors developed a quality assurance (QA) framework for fully automated and time-efficient performance evaluation of these systems. In addition, the dependence of objective Fourier-based IQ metrics on direction and position in 3D volumes was investigated for CBCT. Methods: The authors designed a dedicated QA phantom 10 cm in length consisting of five compartments, each with a diameter of 10 cm, andmore » an optional extension ring 16 cm in diameter. A homogeneous section of water-equivalent material allows measuring CT value accuracy, image noise and uniformity, and multidimensional global and local noise power spectra (NPS). For the quantitative determination of 3D high-contrast spatial resolution, the modulation transfer function (MTF) of centrally and peripherally positioned aluminum spheres was computed from edge profiles. Additional in-plane and axial resolution patterns were used to assess resolution qualitatively. The characterization of low-contrast detectability as well as CT value linearity and artifact behavior was tested by utilizing sections with soft-tissue-equivalent and metallic inserts. For an automated QA procedure, a phantom detection algorithm was implemented. All tests used in the dedicated QA program were initially verified in simulation studies and experimentally confirmed on a clinical dental CBCT system. Results: The automated IQ evaluation of volume data sets of the dental CBCT system was achieved with the proposed phantom requiring only one scan for the determination of all desired parameters. Typically, less than 5 min were needed for phantom set-up, scanning, and data analysis. Quantitative evaluation of system performance over time by comparison to previous examinations was also verified. The maximum percentage interscan variation of repeated measurements was less than 4% and 1.7% on average for all investigated quality criteria. The NPS-based image noise differed by less than 5% from the conventional standard deviation approach and spatially selective 10% MTF values were well comparable to subjective results obtained with 3D resolution pattern. Determining only transverse spatial resolution and global noise behavior in the central field of measurement turned out to be insufficient. Conclusions: The proposed framework transfers QA routines employed in conventional CT in an advanced version to CBCT for fully automated and time-efficient evaluation of technical equipment. With the modular phantom design, a routine as well as an expert version for assessing IQ is provided. The QA program can be used for arbitrary CT units to evaluate 3D imaging characteristics automatically.« less

  2. Global survey of the omega-3 fatty acids, docosahexaenoic acid and eicosapentaenoic acid in the blood stream of healthy adults.

    PubMed

    Stark, Ken D; Van Elswyk, Mary E; Higgins, M Roberta; Weatherford, Charli A; Salem, Norman

    2016-07-01

    Studies reporting blood levels of the omega-3 polyunsaturated fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), were systematically identified in order to create a global map identifying countries and regions with different blood levels. Included studies were those of healthy adults, published in 1980 or later. A total of 298 studies met all inclusion criteria. Studies reported fatty acids in various blood fractions including plasma total lipids (33%), plasma phospholipid (32%), erythrocytes (32%) and whole blood (3.0%). Fatty acid data from each blood fraction were converted to relative weight percentages (wt.%) and then assigned to one of four discrete ranges (high, moderate, low, very low) corresponding to wt.% EPA+DHA in erythrocyte equivalents. Regions with high EPA+DHA blood levels (>8%) included the Sea of Japan, Scandinavia, and areas with indigenous populations or populations not fully adapted to Westernized food habits. Very low blood levels (≤4%) were observed in North America, Central and South America, Europe, the Middle East, Southeast Asia, and Africa. The present review reveals considerable variability in blood levels of EPA+DHA and the very low to low range of blood EPA+DHA for most of the world may increase global risk for chronic disease. Copyright © 2016 The Authors. Published by Elsevier Ltd.. All rights reserved.

  3. Molecular Dynamics Pinpoint the Global Fluorine Effect in Balanoid Binding to PKCε and PKA.

    PubMed

    Hardianto, Ari; Liu, Fei; Ranganathan, Shoba

    2018-02-26

    (-)-Balanol is an adenosine triphosphate mimic that inhibits protein kinase C (PKC) isozymes and cAMP-dependent protein kinase (PKA) with limited selectivity. While PKA is known as a tumor promoter, PKC isozymes can be tumor promoters or suppressors. In particular, PKCε is frequently involved in tumorigenesis and a potential target for anticancer drugs. We recently reported that stereospecific fluorination of balanol yielded a balanoid with enhanced selectivity for PKCε over other PKC isozymes and PKA, although the global fluorine effect behind the selectivity enhancement is not fully understood. Interestingly, in contrast to PKA, PKCε is more sensitive to this fluorine effect. Here we investigate the global fluorine effect on the different binding responses of PKCε and PKA to balanoids using molecular dynamics (MD) simulations. For the first time to the best of our knowledge, we found that a structurally equivalent residue in each kinase, Thr184 in PKA and Ala549 in PKCε, is essential for the different binding responses. Furthermore, the study revealed that the invariant Lys, Lys73 in PKA and Lys437 in PKCε, already known to have a crucial role in the catalytic activity of kinases, serves as the main anchor for balanol binding. Overall, while Thr184 in PKA attenuates the effect of fluorination, Ala549 permits remote response of PKCε to fluorine substitution, with implications for rational design of future balanol-based PKCε inhibitors.

  4. A Prototype Two-Decade Fully-Coupled Fine-Resolution CCSM Simulation

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    McClean, Julie L.; Bader, David C; Bryan, Frank O.

    2011-01-01

    A fully coupled global simulation using the Community Climate System Model (CCSM) was configured using grid resolutions of 0.1{sup o} for the ocean and sea-ice, and 0.25{sup o} for the atmosphere and land, and was run under present-day greenhouse gas conditions for 20 years. It represents one of the first efforts to simulate the planetary system at such high horizontal resolution. The climatology of the circulation of the atmosphere and the upper ocean were compared with observational data and reanalysis products to identify persistent mean climate biases. Intensified and contracted polar vortices, and too cold sea surface temperatures (SSTs) inmore » the subpolar and mid-latitude Northern Hemisphere were the dominant biases produced by the model. Intense category 4 cyclones formed spontaneously in the tropical North Pacific. A case study of the ocean response to one such event shows the realistic formation of a cold SST wake, mixed layer deepening, and warming below the mixed layer. Too many tropical cyclones formed in the North Pacific however, due to too high SSTs in the tropical eastern Pacific. In the North Atlantic anomalously low SSTs lead to a dearth of hurricanes. Agulhas eddy pathways are more realistic than in equivalent stand-alone ocean simulations forced with atmospheric reanalysis.« less

  5. Electrical and mechanical fully coupled theory and experimental verification of Rosen-type piezoelectric transformers.

    PubMed

    Hsu, Yu-Hsiang; Lee, Chih-Kung; Hsiao, Wen-Hsin

    2005-10-01

    A piezoelectric transformer is a power transfer device that converts its input and output voltage as well as current by effectively using electrical and mechanical coupling effects of piezoelectric materials. Equivalent-circuit models, which are traditionally used to analyze piezoelectric transformers, merge each mechanical resonance effect into a series of ordinary differential equations. Because of using ordinary differential equations, equivalent circuit models are insufficient to reflect the mechanical behavior of piezoelectric plates. Electromechanically, fully coupled governing equations of Rosen-type piezoelectric transformers, which are partial differential equations in nature, can be derived to address the deficiencies of the equivalent circuit models. It can be shown that the modal actuator concept can be adopted to optimize the electromechanical coupling effect of the driving section once the added spatial domain design parameters are taken into account, which are three-dimensional spatial dependencies of electromechanical properties. The maximum power transfer condition for a Rosen-type piezoelectric transformer is detailed. Experimental results, which lead us to a series of new design rules, also are presented to prove the validity and effectiveness of the theoretical predictions.

  6. GLOBAL SOLUTIONS TO FOLDED CONCAVE PENALIZED NONCONVEX LEARNING

    PubMed Central

    Liu, Hongcheng; Yao, Tao; Li, Runze

    2015-01-01

    This paper is concerned with solving nonconvex learning problems with folded concave penalty. Despite that their global solutions entail desirable statistical properties, there lack optimization techniques that guarantee global optimality in a general setting. In this paper, we show that a class of nonconvex learning problems are equivalent to general quadratic programs. This equivalence facilitates us in developing mixed integer linear programming reformulations, which admit finite algorithms that find a provably global optimal solution. We refer to this reformulation-based technique as the mixed integer programming-based global optimization (MIPGO). To our knowledge, this is the first global optimization scheme with a theoretical guarantee for folded concave penalized nonconvex learning with the SCAD penalty (Fan and Li, 2001) and the MCP penalty (Zhang, 2010). Numerical results indicate a significant outperformance of MIPGO over the state-of-the-art solution scheme, local linear approximation, and other alternative solution techniques in literature in terms of solution quality. PMID:27141126

  7. Insight into climate change from the carbon exchange of biocrusts utilizing non-rainfall water.

    PubMed

    Ouyang, Hailong; Hu, Chunxiang

    2017-05-31

    Biocrusts are model ecosystems of global change studies. However, light and non-rainfall water (NRW) were previously few considered. Different biocrust types further aggravated the inconsistence. So carbon-exchange of biocrusts (cyanobacteria crusts-AC1/AC2; cyanolichen crust-LC1; chlorolichen crust-LC2; moss crust-MC) utilizing NRW at various temperatures and light-intensities were determined under simulated and insitu mesocosm experiments. Carbon input of all biocrusts were negatively correlated with experimental temperature under all light-intensity with saturated water and stronger light with equivalent NRW, but positively correlated with temperature under weak light with equivalent NRW. LCPs and R/Pg of AC1 were lowest, followed in turn by AC2, LC2 and MC. Thus AC1 had most opportunities to use NRW, and 2.5 °C warming did cause significant changes of carbon exchange. Structural equation models further revealed that air-temperature was most important for carbon-exchange of ACs, but equally important as NRW for LC2 and MC; positive influence of warming on carbon-input in ACs was much stronger than the latter. Therefore, temperature effect on biocrust carbon-input depends on both moisture and light. Meanwhile, the role of NRW, transitional states between ACs, and obvious carbon-fixation differences between lichen crusts should be fully considered in the future study of biocrusts responding to climate change.

  8. Wideband analytical equivalent circuit for one-dimensional periodic stacked arrays.

    PubMed

    Molero, Carlos; Rodríguez-Berral, Raúl; Mesa, Francisco; Medina, Francisco; Yakovlev, Alexander B

    2016-01-01

    A wideband equivalent circuit is proposed for the accurate analysis of scattering from a set of stacked slit gratings illuminated by a plane wave with transverse magnetic or electric polarization that impinges normally or obliquely along one of the principal planes of the structure. The slit gratings are printed on dielectric slabs of arbitrary thickness, including the case of closely spaced gratings that interact by higher-order modes. A Π-circuit topology is obtained for a pair of coupled arrays, with fully analytical expressions for all the circuit elements. This equivalent Π circuit is employed as the basis to derive the equivalent circuit of finite stacks with any given number of gratings. Analytical expressions for the Brillouin diagram and the Bloch impedance are also obtained for infinite periodic stacks.

  9. State dependence of climatic instability over the past 720,000 years from Antarctic ice cores and climate modeling.

    PubMed

    Kawamura, Kenji; Abe-Ouchi, Ayako; Motoyama, Hideaki; Ageta, Yutaka; Aoki, Shuji; Azuma, Nobuhiko; Fujii, Yoshiyuki; Fujita, Koji; Fujita, Shuji; Fukui, Kotaro; Furukawa, Teruo; Furusaki, Atsushi; Goto-Azuma, Kumiko; Greve, Ralf; Hirabayashi, Motohiro; Hondoh, Takeo; Hori, Akira; Horikawa, Shinichiro; Horiuchi, Kazuho; Igarashi, Makoto; Iizuka, Yoshinori; Kameda, Takao; Kanda, Hiroshi; Kohno, Mika; Kuramoto, Takayuki; Matsushi, Yuki; Miyahara, Morihiro; Miyake, Takayuki; Miyamoto, Atsushi; Nagashima, Yasuo; Nakayama, Yoshiki; Nakazawa, Takakiyo; Nakazawa, Fumio; Nishio, Fumihiko; Obinata, Ichio; Ohgaito, Rumi; Oka, Akira; Okuno, Jun'ichi; Okuyama, Junichi; Oyabu, Ikumi; Parrenin, Frédéric; Pattyn, Frank; Saito, Fuyuki; Saito, Takashi; Saito, Takeshi; Sakurai, Toshimitsu; Sasa, Kimikazu; Seddik, Hakime; Shibata, Yasuyuki; Shinbori, Kunio; Suzuki, Keisuke; Suzuki, Toshitaka; Takahashi, Akiyoshi; Takahashi, Kunio; Takahashi, Shuhei; Takata, Morimasa; Tanaka, Yoichi; Uemura, Ryu; Watanabe, Genta; Watanabe, Okitsugu; Yamasaki, Tetsuhide; Yokoyama, Kotaro; Yoshimori, Masakazu; Yoshimoto, Takayasu

    2017-02-01

    Climatic variabilities on millennial and longer time scales with a bipolar seesaw pattern have been documented in paleoclimatic records, but their frequencies, relationships with mean climatic state, and mechanisms remain unclear. Understanding the processes and sensitivities that underlie these changes will underpin better understanding of the climate system and projections of its future change. We investigate the long-term characteristics of climatic variability using a new ice-core record from Dome Fuji, East Antarctica, combined with an existing long record from the Dome C ice core. Antarctic warming events over the past 720,000 years are most frequent when the Antarctic temperature is slightly below average on orbital time scales, equivalent to an intermediate climate during glacial periods, whereas interglacial and fully glaciated climates are unfavourable for a millennial-scale bipolar seesaw. Numerical experiments using a fully coupled atmosphere-ocean general circulation model with freshwater hosing in the northern North Atlantic showed that climate becomes most unstable in intermediate glacial conditions associated with large changes in sea ice and the Atlantic Meridional Overturning Circulation. Model sensitivity experiments suggest that the prerequisite for the most frequent climate instability with bipolar seesaw pattern during the late Pleistocene era is associated with reduced atmospheric CO 2 concentration via global cooling and sea ice formation in the North Atlantic, in addition to extended Northern Hemisphere ice sheets.

  10. State dependence of climatic instability over the past 720,000 years from Antarctic ice cores and climate modeling

    PubMed Central

    Kawamura, Kenji; Abe-Ouchi, Ayako; Motoyama, Hideaki; Ageta, Yutaka; Aoki, Shuji; Azuma, Nobuhiko; Fujii, Yoshiyuki; Fujita, Koji; Fujita, Shuji; Fukui, Kotaro; Furukawa, Teruo; Furusaki, Atsushi; Goto-Azuma, Kumiko; Greve, Ralf; Hirabayashi, Motohiro; Hondoh, Takeo; Hori, Akira; Horikawa, Shinichiro; Horiuchi, Kazuho; Igarashi, Makoto; Iizuka, Yoshinori; Kameda, Takao; Kanda, Hiroshi; Kohno, Mika; Kuramoto, Takayuki; Matsushi, Yuki; Miyahara, Morihiro; Miyake, Takayuki; Miyamoto, Atsushi; Nagashima, Yasuo; Nakayama, Yoshiki; Nakazawa, Takakiyo; Nakazawa, Fumio; Nishio, Fumihiko; Obinata, Ichio; Ohgaito, Rumi; Oka, Akira; Okuno, Jun’ichi; Okuyama, Junichi; Oyabu, Ikumi; Parrenin, Frédéric; Pattyn, Frank; Saito, Fuyuki; Saito, Takashi; Saito, Takeshi; Sakurai, Toshimitsu; Sasa, Kimikazu; Seddik, Hakime; Shibata, Yasuyuki; Shinbori, Kunio; Suzuki, Keisuke; Suzuki, Toshitaka; Takahashi, Akiyoshi; Takahashi, Kunio; Takahashi, Shuhei; Takata, Morimasa; Tanaka, Yoichi; Uemura, Ryu; Watanabe, Genta; Watanabe, Okitsugu; Yamasaki, Tetsuhide; Yokoyama, Kotaro; Yoshimori, Masakazu; Yoshimoto, Takayasu

    2017-01-01

    Climatic variabilities on millennial and longer time scales with a bipolar seesaw pattern have been documented in paleoclimatic records, but their frequencies, relationships with mean climatic state, and mechanisms remain unclear. Understanding the processes and sensitivities that underlie these changes will underpin better understanding of the climate system and projections of its future change. We investigate the long-term characteristics of climatic variability using a new ice-core record from Dome Fuji, East Antarctica, combined with an existing long record from the Dome C ice core. Antarctic warming events over the past 720,000 years are most frequent when the Antarctic temperature is slightly below average on orbital time scales, equivalent to an intermediate climate during glacial periods, whereas interglacial and fully glaciated climates are unfavourable for a millennial-scale bipolar seesaw. Numerical experiments using a fully coupled atmosphere-ocean general circulation model with freshwater hosing in the northern North Atlantic showed that climate becomes most unstable in intermediate glacial conditions associated with large changes in sea ice and the Atlantic Meridional Overturning Circulation. Model sensitivity experiments suggest that the prerequisite for the most frequent climate instability with bipolar seesaw pattern during the late Pleistocene era is associated with reduced atmospheric CO2 concentration via global cooling and sea ice formation in the North Atlantic, in addition to extended Northern Hemisphere ice sheets. PMID:28246631

  11. 78 FR 79710 - New Postal Product

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-31

    ... Functionally Equivalent Global Expedited Package Services 3 Negotiated Service Agreement and Application for Non-Public Treatment of Materials Filed Under Seal, December 23, 2013 (Notice). II. Background The.... CP2010-71 to serve as the baseline agreement for comparison of potentially functionally equivalent...

  12. The Quadrennial Review of Military Compensation (3rd). Staff Studies and Selected Supporting Papers. Volume 9. Reserve Compensation, Sample Foreign Pay Systems

    DTIC Science & Technology

    1976-12-01

    System * 4. Fringe Benefits 5. Government Incurred Costs 6. Military Compensatioh Item 7. Military Equivalent Salary 114. Military Salary System 9. Non ...compensation whereby the military equivalent salary is paid entirely in cash and is fully taxable. 9. Non -Compensation Benefit a. An advantage to a service...other circumstances, the rate is 50 p daily. o Disturbance Allowance. The Disturbance Alowance is a non -taxable allowance designed to help pay for the

  13. Future change in seasonal march of snow water equivalent due to global climate change

    NASA Astrophysics Data System (ADS)

    Hara, M.; Kawase, H.; Ma, X.; Wakazuki, Y.; Fujita, M.; Kimura, F.

    2012-04-01

    Western side of Honshu Island in Japan is one of the heaviest snowfall areas in the world, although the location is relatively lower latitude than other heavy snowfall areas. Snowfall is one of major source for agriculture, industrial, and house-use in Japan. The change in seasonal march of snow water equivalent, e.g., snowmelt season and amount will strongly influence to social-economic activities (ex. Ma et al., 2011). We performed the four numerical experiments including present and future climate simulations and much-snow and less-snow cases using a regional climate model. Pseudo-Global-Warming (PGW) method (Kimura and Kitoh, 2008) is applied for the future climate simulations. NCEP/NCAR reanalysis is used for initial and boundary conditions in present climate simulation and PGW method. MIROC 3.2 medres 2070s output under IPCC SRES A2 scenario and 1990s output under 20c3m scenario used for PGW method. In much-snow cases, Maximum total snow water equivalent over Japan, which is mostly observed in early February, is 49 G ton in the present simulation, the one decreased 26 G ton in the future simulation. The decreasing rate of snow water equivalent due to climate change was 49%. Main cause of the decrease of the total snow water equivalent is strongly affected by the air temperature rise due to global climate change. The difference in present and future precipitation amount is little.

  14. Motivating patients to exercise: translating high blood pressure into equivalent risk of inactivity.

    PubMed

    Li, Chu-Shiu; Liu, Chwen-Chi; Tsai, Min-Kuang; Tai, Ya-Ping; Wai, Jackson Pui Man; Tsao, Chwen-Keng; Wen, Chi-Pang

    2015-02-01

    Even with the 2008 physical activity guidelines for Americans and the strong epidemiological evidence, physicians are not routinely emphasizing the importance of exercise. We try to explore an innovative way to communicate the benefits of physical activity in a term familiar to patients. A cohort of 470, 163 adults from a medical screening program in Taiwan were recruited between 1994 and 2008. Their vital status was followed up by matching with the National Death File. Individuals were classified as 'inactive', 'low active', or 'fully active', with 'fully active' meeting the current exercise recommendation of 150  min per week or more. Cox proportional model was used to calculate the hazard ratio. More than one-half of the cohort was inactive (54%), with one-quarter fully active (24%). One in seven was hypertensive (14%), defined as SBP at least 140  mmHg. Among the hypertensive individuals, mortality risks were increased by 37% for the inactive. Inactive individuals had higher all-cause mortality than active ones across all blood pressure (BP) levels. At 110-119  mmHg, the inactive had a risk as high as the risk at 155  mmHg, an increased mortality risk equivalent to a risk of BP increase of 41.2 mmHg. The mortality risk of being inactive was equivalent to an increase of around 40  mmHg in SBP or 20  mmHg in DBP, a number relevant to hypertensive patients. Appreciating this relationship may convince the inactive to start exercising, a behavior as important as controlling BP.

  15. Repeated folding stress-induced morphological changes in the dermal equivalent.

    PubMed

    Arai, Koji Y; Sugimoto, Mami; Ito, Kanako; Ogura, Yuki; Akutsu, Nobuko; Amano, Satoshi; Adachi, Eijiro; Nishiyama, Toshio

    2014-11-01

    Repeated mechanical stresses applied to the same region of the skin are thought to induce morphological changes known as wrinkle. However, the underlying mechanisms are not fully understood. To study the mechanisms, we examined effects of repeated mechanical stress on the dermal equivalent. We developed a novel device to apply repeated folding stress to the dermal equivalent. After applying the mechanical stress, morphological changes of the dermal equivalent and expression of several genes related to extracellular matrix turn over and cell contraction were examined. The repeated folding stress induced a noticeable decrease in the width of the dermal equivalent. The mechanical stress altered orientations of collagen fibrils. Hydroxyproline contents, dry weights and cell viability of the dermal equivalents were not affected by the mechanical stress. On the other hand, Rho-associated coiled-coil-containing kinase (ROCK) specific inhibitor Y27632 completely suppressed the decrease in the width of the dermal equivalent. The present results revealed that either degradation of collagen or changes in the number of cells were not responsible for the decrease in the width of the dermal equivalent and indicate that the repeated mechanical stress induces unidirectional contraction in the dermal equivalent through the RhoA-ROCK signaling pathway. © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  16. Statistical equivalence and test-retest reliability of delay and probability discounting using real and hypothetical rewards.

    PubMed

    Matusiewicz, Alexis K; Carter, Anne E; Landes, Reid D; Yi, Richard

    2013-11-01

    Delay discounting (DD) and probability discounting (PD) refer to the reduction in the subjective value of outcomes as a function of delay and uncertainty, respectively. Elevated measures of discounting are associated with a variety of maladaptive behaviors, and confidence in the validity of these measures is imperative. The present research examined (1) the statistical equivalence of discounting measures when rewards were hypothetical or real, and (2) their 1-week reliability. While previous research has partially explored these issues using the low threshold of nonsignificant difference, the present study fully addressed this issue using the more-compelling threshold of statistical equivalence. DD and PD measures were collected from 28 healthy adults using real and hypothetical $50 rewards during each of two experimental sessions, one week apart. Analyses using area-under-the-curve measures revealed a general pattern of statistical equivalence, indicating equivalence of real/hypothetical conditions as well as 1-week reliability. Exceptions are identified and discussed. Copyright © 2013 Elsevier B.V. All rights reserved.

  17. A new learning algorithm for a fully connected neuro-fuzzy inference system.

    PubMed

    Chen, C L Philip; Wang, Jing; Wang, Chi-Hsu; Chen, Long

    2014-10-01

    A traditional neuro-fuzzy system is transformed into an equivalent fully connected three layer neural network (NN), namely, the fully connected neuro-fuzzy inference systems (F-CONFIS). The F-CONFIS differs from traditional NNs by its dependent and repeated weights between input and hidden layers and can be considered as the variation of a kind of multilayer NN. Therefore, an efficient learning algorithm for the F-CONFIS to cope these repeated weights is derived. Furthermore, a dynamic learning rate is proposed for neuro-fuzzy systems via F-CONFIS where both premise (hidden) and consequent portions are considered. Several simulation results indicate that the proposed approach achieves much better accuracy and fast convergence.

  18. Multidatabase Query Processing with Uncertainty in Global Keys and Attribute Values.

    ERIC Educational Resources Information Center

    Scheuermann, Peter; Li, Wen-Syan; Clifton, Chris

    1998-01-01

    Presents an approach for dynamic database integration and query processing in the absence of information about attribute correspondences and global IDs. Defines different types of equivalence conditions for the construction of global IDs. Proposes a strategy based on ranked role-sets that makes use of an automated semantic integration procedure…

  19. Global Competition, Coloniality, and the Geopolitics of Knowledge in Higher Education

    ERIC Educational Resources Information Center

    Shahjahan, Riyad A.; Morgan, Clara

    2016-01-01

    While scholars have analyzed global higher education (HE) competition, they have largely failed to address how global spaces of equivalence are tied both to coloniality and to competition. Using the OECD's International Assessment of Higher Education Learning Outcomes (AHELO) as a case study and drawing on concepts from coloniality including…

  20. The Short Form 36 English and Chinese versions were equivalent in a multiethnic Asian population.

    PubMed

    Tan, Maudrene L S; Wee, Hwee-Lin; Lee, Jeannette; Ma, Stefan; Heng, Derrick; Tai, E-Shyong; Thumboo, Julian

    2013-07-01

    The primary aim of this article was to evaluate measurement equivalence of the English and Chinese versions of the Short Form 36 version 2 (SF-36v2) and Short Form 6D (SF-6D). In this cross-sectional study, health-related quality of life (HRQoL) was measured from 4,973 ethnic Chinese subjects using the SF-36v2 questionnaire. Measurement equivalence of domain and utility scores for the English- and Chinese-language SF-36v2 and SF-6D were assessed by examining the score differences between the two languages using linear regression models, with and without adjustment for known determinants of HRQoL. Equivalence was achieved if the 90% confidence interval (CI) of the differences in scores, due to language, fell within a predefined equivalence margin. Compared with English-speaking Chinese, Chinese-speaking Chinese were significantly older (47.6 vs. 55.5 years). All SF-36v2 domains were equivalent after adjusting for known HRQoL. SF-6D utility/items had the 90% CI either fully or partially overlap their predefined equivalence margin. The English- and Chinese-language versions of the SF-36v2 and SF-6D demonstrated equivalence. Copyright © 2013 Elsevier Inc. All rights reserved.

  1. Requirements to Design to Code: Towards a Fully Formal Approach to Automatic Code Generation

    NASA Technical Reports Server (NTRS)

    Hinchey, Michael G.; Rash, James L.; Rouff, Christopher A.

    2004-01-01

    A general-purpose method to mechanically transform system requirements into a provably equivalent model has yet to appear. Such a method represents a necessary step toward high-dependability system engineering for numerous possible application domains, including sensor networks and autonomous systems. Currently available tools and methods that start with a formal model of a system and mechanically produce a provably equivalent implementation are valuable but not sufficient. The gap that current tools and methods leave unfilled is that their formal models cannot be proven to be equivalent to the system requirements as originated by the customer. For the classes of systems whose behavior can be described as a finite (but significant) set of scenarios, we offer a method for mechanically transforming requirements (expressed in restricted natural language, or in other appropriate graphical notations) into a provably equivalent formal model that can be used as the basis for code generation and other transformations.

  2. Global equivalent magnetization of the oceanic lithosphere

    NASA Astrophysics Data System (ADS)

    Dyment, J.; Choi, Y.; Hamoudi, M.; Lesur, V.; Thebault, E.

    2015-11-01

    As a by-product of the construction of a new World Digital Magnetic Anomaly Map over oceanic areas, we use an original approach based on the global forward modeling of seafloor spreading magnetic anomalies and their comparison to the available marine magnetic data to derive the first map of the equivalent magnetization over the World's ocean. This map reveals consistent patterns related to the age of the oceanic lithosphere, the spreading rate at which it was formed, and the presence of mantle thermal anomalies which affects seafloor spreading and the resulting lithosphere. As for the age, the equivalent magnetization decreases significantly during the first 10-15 Myr after its formation, probably due to the alteration of crustal magnetic minerals under pervasive hydrothermal alteration, then increases regularly between 20 and 70 Ma, reflecting variations in the field strength or source effects such as the acquisition of a secondary magnetization. As for the spreading rate, the equivalent magnetization is twice as strong in areas formed at fast rate than in those formed at slow rate, with a threshold at ∼40 km/Myr, in agreement with an independent global analysis of the amplitude of Anomaly 25. This result, combined with those from the study of the anomalous skewness of marine magnetic anomalies, allows building a unified model for the magnetic structure of normal oceanic lithosphere as a function of spreading rate. Finally, specific areas affected by thermal mantle anomalies at the time of their formation exhibit peculiar equivalent magnetization signatures, such as the cold Australian-Antarctic Discordance, marked by a lower magnetization, and several hotspots, marked by a high magnetization.

  3. Essential Foundations for Establishing Equivalence in Cross-National Higher Education Assessment

    ERIC Educational Resources Information Center

    Richardson, Sarah; Coates, Hamish

    2014-01-01

    The global context of contemporary higher education demands international benchmarks. Quality assurance of teaching and learning would benefit from the insights gained from cross-cultural assessments. If cross-cultural assessments are used it is imperative that equivalence is assured, requiring attention to the technical standards used. In this…

  4. Knowledge Hierarchies in Transnational Education: Staging Dissensus. Routledge Research in International and Comparative Education

    ERIC Educational Resources Information Center

    Qi, Jing

    2015-01-01

    Transnational education seeks equivalence in standards and/or relevance of outcomes through the transfer of Western theories, concepts and methods. Utilising a critique-interpretative approach, Jing Qi argues that equivalence/relevance-oriented approaches to transnational education assume the legitimacy of the global knowledge hierarchy.…

  5. 9 CFR 381.150 - Requirements for the production of fully cooked poultry products and partially cooked poultry...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... standards: (1) Lethality. A 7-log10 reduction of Salmonella or an alternative lethality that achieves an equivalent probability that no viable Salmonella organisms remain in the finished product, as well as the...

  6. 5 CFR 430.207 - Monitoring performance.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... appraisal program shall include methods for appraising each critical and non-critical element during the appraisal period. Performance on each critical and non-critical element shall be appraised against its... provide assistance whenever performance is determined to be below “Fully Successful” or equivalent but...

  7. 5 CFR 430.207 - Monitoring performance.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... appraisal program shall include methods for appraising each critical and non-critical element during the appraisal period. Performance on each critical and non-critical element shall be appraised against its... provide assistance whenever performance is determined to be below “Fully Successful” or equivalent but...

  8. Validation of artificial skin equivalents as in vitro testing systems

    NASA Astrophysics Data System (ADS)

    Schmitt, Robert; Marx, Ulrich; Walles, Heike; Schober, Lena

    2011-03-01

    With the increasing complexity of the chemical composition of pharmaceuticals, cosmetics and everyday substances, the awareness of potential health issues and long term damages for humanoid organs is shifting into focus. Artificial in vitro testing systems play an important role in providing reliable test conditions and replacing precarious animal testing. Especially artificial skin equivalents ASEs are used for a broad spectrum of studies like penetration, irritation and corrosion of substances. One major challenge in tissue engineering is the qualification of each individual ASE as in vitro testing system. Due to biological fluctuations, the stratum corneum hornified layer of some ASEs may not fully develop or other defects might occur. For monitoring these effects we developed an fully automated Optical Coherence Tomography device. Here, we present different methods to characterize and evaluate the quality of the ASEs based on image and data processing of OCT B-scans. By analysing the surface structure, defects, like cuts or tears, are detectable. A further indicator for the quality of the ASE is the morphology of the tissue. This allows to determine if the skin model has reached the final growth state. We found, that OCT is a well suited technology for automatically characterizing artificial skin equivalents and validating the application as testing system.

  9. Building confidence and credibility amid growing model and computing complexity

    NASA Astrophysics Data System (ADS)

    Evans, K. J.; Mahajan, S.; Veneziani, C.; Kennedy, J. H.

    2017-12-01

    As global Earth system models are developed to answer an ever-wider range of science questions, software products that provide robust verification, validation, and evaluation must evolve in tandem. Measuring the degree to which these new models capture past behavior, predict the future, and provide the certainty of predictions is becoming ever more challenging for reasons that are generally well known, yet are still challenging to address. Two specific and divergent needs for analysis of the Accelerated Climate Model for Energy (ACME) model - but with a similar software philosophy - are presented to show how a model developer-based focus can address analysis needs during expansive model changes to provide greater fidelity and execute on multi-petascale computing facilities. A-PRIME is a python script-based quick-look overview of a fully-coupled global model configuration to determine quickly if it captures specific behavior before significant computer time and expense is invested. EVE is an ensemble-based software framework that focuses on verification of performance-based ACME model development, such as compiler or machine settings, to determine the equivalence of relevant climate statistics. The challenges and solutions for analysis of multi-petabyte output data are highlighted from the aspect of the scientist using the software, with the aim of fostering discussion and further input from the community about improving developer confidence and community credibility.

  10. ARES v2: new features and improved performance

    NASA Astrophysics Data System (ADS)

    Sousa, S. G.; Santos, N. C.; Adibekyan, V.; Delgado-Mena, E.; Israelian, G.

    2015-05-01

    Aims: We present a new upgraded version of ARES. The new version includes a series of interesting new features such as automatic radial velocity correction, a fully automatic continuum determination, and an estimation of the errors for the equivalent widths. Methods: The automatic correction of the radial velocity is achieved with a simple cross-correlation function, and the automatic continuum determination, as well as the estimation of the errors, relies on a new approach to evaluating the spectral noise at the continuum level. Results: ARES v2 is totally compatible with its predecessor. We show that the fully automatic continuum determination is consistent with the previous methods applied for this task. It also presents a significant improvement on its performance thanks to the implementation of a parallel computation using the OpenMP library. Automatic Routine for line Equivalent widths in stellar Spectra - ARES webpage: http://www.astro.up.pt/~sousasag/ares/Based on observations made with ESO Telescopes at the La Silla Paranal Observatory under programme ID 075.D-0800(A).

  11. A Lightweight, Direct-Drive, Fully Superconducting Generator for Large Wind Turbines

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Meinke, Rainer; Morrison, Darrell; Prince, Vernon Gregory

    2014-12-31

    The current trend in the offshore wind turbine industry favors direct-drive generators based on permanent magnets, as they allow for a simple and reliable drivetrain without a gearbox. These generators, however, do not scale very well to high power levels beneficial for offshore wind, and their use in wind turbines over 6 MW is questionable in terms of mass and economic feasibility. Moreover, rare earth materials composing the permanent magnets are becoming less available, more costly and potentially unavailable in the foreseeable future. A stated goal of the DOE is a critical materials strategy that pursues the development of substitutemore » materials and technology for rare earth materials to improve supply chain flexibility and meet the needs of the clean energy economy.Therefore, alternative solutions are needed, in terms of both favorable up-scaling and minimizing or eliminating the use of permanent magnets. The generator design presented in this document addresses both these issues with the development of a fully superconducting generator (FSG) with unprecedented high specific torque. A full-scale, 10-MW, 10-rpm generator will weigh less about 150 metric tons, compared to 300 metric tons for an equivalent direct-drive, permanent magnet generator. The developed concept does not use any rare earth materials in its critical drive components, but rather relies on a superconductor composed of mainly magnesium and boron (MgB2), both of which are in abundant supply from multiple global sources.« less

  12. Developing Successful Global Leaders

    ERIC Educational Resources Information Center

    Training, 2011

    2011-01-01

    Everyone seems to agree the world desperately needs strong leaders who can manage a global workforce and all the inherent challenges that go with it. That's a big part of the raison d'etre for global leadership development programs. But are today's organizations fully utilizing these programs to develop global leaders, and, if so, are they…

  13. Global MHD simulation of magnetosphere using HPF

    NASA Astrophysics Data System (ADS)

    Ogino, T.

    We have translated a 3-dimensional magnetohydrodynamic (MHD) simulation code of the Earth's magnetosphere from VPP Fortran to HPF/JA on the Fujitsu VPP5000/56 vector-parallel supercomputer and the MHD code was fully vectorized and fully parallelized in VPP Fortran. The entire performance and capability of the HPF MHD code could be shown to be almost comparable to that of VPP Fortran. A 3-dimensional global MHD simulation of the earth's magnetosphere was performed at a speed of over 400 Gflops with an efficiency of 76.5% using 56 PEs of Fujitsu VPP5000/56 in vector and parallel computation that permitted comparison with catalog values. We have concluded that fluid and MHD codes that are fully vectorized and fully parallelized in VPP Fortran can be translated with relative ease to HPF/JA, and a code in HPF/JA may be expected to perform comparably to the same code written in VPP Fortran.

  14. Near Infrared Multispectral Mapping of Venus Supports the Hypothesis that Tessera Plateau Material was Formed in the Presence of Surface Water

    NASA Astrophysics Data System (ADS)

    Mueller, N. T.; Tsang, C.; Nunes, D. C.; Helbert, J.; Dyar, M. D.; Smrekar, S. E.

    2017-12-01

    The VIRTIS instrument on Venus Express observed surface thermal emission from the surface. Studies of 1020nm data showed that tessera plateaus, intensely tectonically deformed highlands that predate most other terrains, have significantly lower thermal emission than other highlands. Lower thermal emission could be due either to lower surface emissivity, supporting the hypothesis that tessera are analogous to continental crust on Earth, or to a bias of Magellan altimetry, which does not fully resolve the topographic relief of tessera terrain. To eliminate this ambiguity, we additionally investigate the spectral windows at 1100 and 1180nm. Data are reduced to surface emissivity using an atmospheric radiative transfer model to account for atmospheric scattering and absorption/emission. Magellan altimetry was used to model atmospheric column height and surface temperature. The model uses a binary (collision-induced) absorption coefficient for each window. It fits absolute radiance and gradient with surface elevation reasonably well, although there are indications that the assumed adiabatic temperature lapse rate is not appropriate globally. The 1100nm band has a relatively low signal-to-noise ratio at the latitudes of the tessera plateaus, but Alpha Regio is visible in both the 1020 and the 1180nm band. The difference in emissivity between Alpha and the adjacent corona Eve, which has a similar elevation as Alpha, is 3.6% at 1020nm, but only 2% at 1180nm. The altimetry bias equivalent to the 1020nm deviation is 230 m, while the equivalent is only 70m at 1180nm. An altimetry bias therefore cannot fully explain the observations, and there must be a real difference in emissivity. The observations are consistent with the hypothesis that Alpha Regio has a more felsic composition. The emissivity spectra of granites at Venus temperatures are lower than those of basalt at 1020nm, but the difference decreases or vanishes towards the 1180nm window. The most plausible explanation for continent-sized felsic plateaus would be a formation analogous to Earth's continents, i.e. differentiation of basaltic crust in the presence of water.

  15. Ecological Equivalence Assessment Methods: What Trade-Offs between Operationality, Scientific Basis and Comprehensiveness?

    PubMed

    Bezombes, Lucie; Gaucherand, Stéphanie; Kerbiriou, Christian; Reinert, Marie-Eve; Spiegelberger, Thomas

    2017-08-01

    In many countries, biodiversity compensation is required to counterbalance negative impacts of development projects on biodiversity by carrying out ecological measures, called offset when the goal is to reach "no net loss" of biodiversity. One main issue is to ensure that offset gains are equivalent to impact-related losses. Ecological equivalence is assessed with ecological equivalence assessment methods taking into account a range of key considerations that we summarized as ecological, spatial, temporal, and uncertainty. When equivalence assessment methods take into account all considerations, we call them "comprehensive". Equivalence assessment methods should also aim to be science-based and operational, which is challenging. Many equivalence assessment methods have been developed worldwide but none is fully satisfying. In the present study, we examine 13 equivalence assessment methods in order to identify (i) their general structure and (ii) the synergies and trade-offs between equivalence assessment methods characteristics related to operationality, scientific-basis and comprehensiveness (called "challenges" in his paper). We evaluate each equivalence assessment methods on the basis of 12 criteria describing the level of achievement of each challenge. We observe that all equivalence assessment methods share a general structure, with possible improvements in the choice of target biodiversity, the indicators used, the integration of landscape context and the multipliers reflecting time lags and uncertainties. We show that no equivalence assessment methods combines all challenges perfectly. There are trade-offs between and within the challenges: operationality tends to be favored while scientific basis are integrated heterogeneously in equivalence assessment methods development. One way of improving the challenges combination would be the use of offset dedicated data-bases providing scientific feedbacks on previous offset measures.

  16. Differences between near-surface equivalent temperature and temperature trends for the Eastern United States. Equivalent temperature as an alternative measure of heat content

    USGS Publications Warehouse

    Davey, C.A.; Pielke, R.A.; Gallo, K.P.

    2006-01-01

    There is currently much attention being given to the observed increase in near-surface air temperatures during the last century. The proper investigation of heating trends, however, requires that we include surface heat content to monitor this aspect of the climate system. Changes in heat content of the Earth's climate are not fully described by temperature alone. Moist enthalpy or, alternatively, equivalent temperature, is more sensitive to surface vegetation properties than is air temperature and therefore more accurately depicts surface heating trends. The microclimates evident at many surface observation sites highlight the influence of land surface characteristics on local surface heating trends. Temperature and equivalent temperature trend differences from 1982-1997 are examined for surface sites in the Eastern U.S. Overall trend differences at the surface indicate equivalent temperature trends are relatively warmer than temperature trends in the Eastern U.S. Seasonally, equivalent temperature trends are relatively warmer than temperature trends in winter and are relatively cooler in the fall. These patterns, however, vary widely from site to site, so local microclimate is very important. ?? 2006 Elsevier B.V. All rights reserved.

  17. Equivalent damage: A critical assessment

    NASA Technical Reports Server (NTRS)

    Laflen, J. R.; Cook, T. S.

    1982-01-01

    Concepts in equivalent damage were evaluated to determine their applicability to the life prediction of hot path components of aircraft gas turbine engines. Equivalent damage was defined as being those effects which influence the crack initiation life-time beyond the damage that is measured in uniaxial, fully-reversed sinusoidal and isothermal experiments at low homologous temperatures. Three areas of equivalent damage were examined: mean stress, cumulative damage, and multiaxiality. For each area, a literature survey was conducted to aid in selecting the most appropriate theories. Where possible, data correlations were also used in the evaluation process. A set of criteria was developed for ranking the theories in each equivalent damage regime. These criteria considered aspects of engine utilization as well as the theoretical basis and correlative ability of each theory. In addition, consideration was given to the complex nature of the loading cycle at fatigue critical locations of hot path components; this loading includes non-proportional multiaxial stressing, combined temperature and strain fluctuations, and general creep-fatigue interactions. Through applications of selected equivalent damage theories to some suitable data sets it was found that there is insufficient data to allow specific recommendations of preferred theories for general applications. A series of experiments and areas of further investigations were identified.

  18. Global Education Implications of the Foreign Pharmacy Graduate Equivalency Examination

    PubMed Central

    Clauson, Kevin A.; Latif, David A.; Al-Rousan, Rabaa M.

    2010-01-01

    Although the Foreign Pharmacy Graduate Equivalency Examination (FPGEE) is not intended to measure educational outcomes or institutional effectiveness, it may be a reliable and valid criterion to assess the quality or success of international pharmacy programs. This comprehensive review describes the evolution and historical milestones of the FPGEE, along with trends in structure, administration, and passing rates, and the impact of country of origin on participant performance. Similarities between the FPGEE and the Pharmacy Curriculum Outcomes Assessment (PCOA) are also explored. This paper aims to provide a global prospective and insight for foreign academic institutions into parameters for evaluating their students' educational capabilities. PMID:20798798

  19. Team Formation in Partially Observable Multi-Agent Systems

    NASA Technical Reports Server (NTRS)

    Agogino, Adrian K.; Tumer, Kagan

    2004-01-01

    Sets of multi-agent teams often need to maximize a global utility rating the performance of the entire system where a team cannot fully observe other teams agents. Such limited observability hinders team-members trying to pursue their team utilities to take actions that also help maximize the global utility. In this article, we show how team utilities can be used in partially observable systems. Furthermore, we show how team sizes can be manipulated to provide the best compromise between having easy to learn team utilities and having them aligned with the global utility, The results show that optimally sized teams in a partially observable environments outperform one team in a fully observable environment, by up to 30%.

  20. CONCEPTUAL BASIS FOR NATURAL ATTENUATION (NA) AS REMEDIATION APPROACH

    EPA Science Inventory

    As used in enforcement actions at hazardous waste sites by U.S. EPA, monitored natural attenuation is a remedy fully equivalent to any other remedy. The acceptance of MNA is based on three lines of evidence: historical ground water and/or soil chemistry data that demonstrates a ...

  1. 5 CFR 330.702 - Definitions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ...) Received a reduction in force (RIF) separation notice under part 351 of this chapter and has not declined... record was at least fully successful (Level 3) or equivalent who was either: (i) Separated by RIF under... appointment eligibility and selection priority for competitive service positions; and (ii) Has received a RIF...

  2. 5 CFR 330.702 - Definitions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ...) Received a reduction in force (RIF) separation notice under part 351 of this chapter and has not declined... record was at least fully successful (Level 3) or equivalent who was either: (i) Separated by RIF under... appointment eligibility and selection priority for competitive service positions; and (ii) Has received a RIF...

  3. 5 CFR 330.702 - Definitions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ...) Received a reduction in force (RIF) separation notice under part 351 of this chapter and has not declined... record was at least fully successful (Level 3) or equivalent who was either: (i) Separated by RIF under... appointment eligibility and selection priority for competitive service positions; and (ii) Has received a RIF...

  4. 29 CFR 1910.68 - Manlifts.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... balance. (2) Open type. One which has a handgrip surface fully exposed and capable of being encircled by... not less than No. 18 U.S. gauge sheet steel or material of equivalent strength or stiffness. The lower... type controller contacts carrying the main motor current shall be copper to carbon or equal, except...

  5. 5 CFR 531.404 - Earning within-grade increase.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ...) upon meeting the following three requirements established by law: (a) The employee's performance must be at an acceptable level of competence, as defined in this subpart. To be determined at an... chapter) shall be at least Level 3 (“Fully Successful” or equivalent). (1) When a within-grade increase...

  6. Global Citizenship Education for Every Student: The Washington, DC Public Schools' Study Abroad Program

    ERIC Educational Resources Information Center

    Engel, Laura C.; Fundalinski, Jessica; Gatalica, Kayla; Gibson, Heidi; Ireland, Kate

    2017-01-01

    What if every child could have a global experience? While such an idea might sound far-fetched, one school district is trying to change the narrative about access to study abroad through a large, fully-funded, district-wide global travel program.

  7. Requirements to Design to Code: Towards a Fully Formal Approach to Automatic Code Generation

    NASA Technical Reports Server (NTRS)

    Hinchey, Michael G.; Rash, James L.; Rouff, Christopher A.

    2005-01-01

    A general-purpose method to mechanically transform system requirements into a provably equivalent model has yet to appear. Such a method represents a necessary step toward high-dependability system engineering for numerous possible application domains, including distributed software systems, sensor networks, robot operation, complex scripts for spacecraft integration and testing, and autonomous systems. Currently available tools and methods that start with a formal model of a system and mechanically produce a provably equivalent implementation are valuable but not sufficient. The gap that current tools and methods leave unfilled is that their formal models cannot be proven to be equivalent to the system requirements as originated by the customer. For the classes of systems whose behavior can be described as a finite (but significant) set of scenarios, we offer a method for mechanically transforming requirements (expressed in restricted natural language, or in other appropriate graphical notations) into a provably equivalent formal model that can be used as the basis for code generation and other transformations.

  8. Requirements to Design to Code: Towards a Fully Formal Approach to Automatic Code Generation

    NASA Technical Reports Server (NTRS)

    Hinchey, Michael G.; Rash, James L.; Rouff, Christopher A.

    2005-01-01

    A general-purpose method to mechanically transform system requirements into a provably equivalent model has yet to appear. Such a method represents a necessary step toward high-dependability system engineering for numerous possible application domains, including distributed software systems, sensor networks, robot operation, complex scripts for spacecraft integration and testing, and autonomous systems. Currently available tools and methods that start with a formal model of a: system and mechanically produce a provably equivalent implementation are valuable but not sufficient. The "gap" that current tools and methods leave unfilled is that their formal models cannot be proven to be equivalent to the system requirements as originated by the customer. For the ciasses of systems whose behavior can be described as a finite (but significant) set of scenarios, we offer a method for mechanically transforming requirements (expressed in restricted natural language, or in other appropriate graphical notations) into a provably equivalent formal model that can be used as the basis for code generation and other transformations.

  9. Simulations of Flame Acceleration and DDT in Mixture Composition Gradients

    NASA Astrophysics Data System (ADS)

    Zheng, Weilin; Kaplan, Carolyn; Houim, Ryan; Oran, Elaine

    2017-11-01

    Unsteady, multidimensional, fully compressible numerical simulations of methane-air in an obstructed channel with spatial gradients in equivalence ratios have been carried to determine the effects of the gradients on flame acceleration and transition to detonation. Results for gradients perpendicular to the propagation direction were considered here. A calibrated, optimized chemical-diffusive model that reproduces correct flame and detonation properties for methane-air over a range of equivalence ratios was derived from a combination of a genetic algorithm with a Nelder-Mead optimization scheme. Inhomogeneous mixtures of methane-air resulted in slower flame acceleration and longer distance to DDT. Detonations were more likely to decouple into a flame and a shock under sharper concentration gradients. Detailed analyses of temperature and equivalence ratio illustrated that vertical gradients can greatly affect the formation of hot spots that initiate detonation by changing the strength of leading shock wave and local equivalence ratio near the base of obstacles. This work is supported by the Alpha Foundation (Grant No. AFC215-20).

  10. Impact of a small ellipticity on the sustainability condition of developed turbulence in a precessing spheroid

    NASA Astrophysics Data System (ADS)

    Horimoto, Yasufumi; Simonet-Davin, Gabriel; Katayama, Atsushi; Goto, Susumu

    2018-04-01

    We experimentally investigate the flow transition to developed turbulence in a precessing spheroid with a small ellipticity. Fully developed turbulence appears through a subcritical transition when we fix the Reynolds number (the spin rate) and gradually increase the Poincaré number (the precession rate). In the transitional range of the Poincaré number, two qualitatively different turbulent states (i.e., fully developed turbulence and quiescent turbulence with a spin-driven global circulation) are stable and they are connected by a hysteresis loop. This discontinuous transition is in contrast to the continuous transition in a precessing sphere, for which neither bistable turbulent states nor hysteresis loops are observed. The small ellipticity of the container makes the global circulation of the confined fluid more stable, and it requires much stronger precession of the spheroid, than a sphere, for fully developed turbulence to be sustained. Nevertheless, once fully developed turbulence is sustained, its flow structures are almost identical in the spheroid and sphere. The argument [Lorenzani and Tilgner, J. Fluid Mech. 492, 363 (2003), 10.1017/S002211200300572X; Noir et al., Geophys. J. Int. 154, 407 (2003), 10.1046/j.1365-246X.2003.01934.x] on the basis of the analytical solution [Busse, J. Fluid Mech. 33, 739 (1968), 10.1017/S0022112068001655] of the steady global circulation in a weak precession range well describes the onset of the fully developed turbulence in the spheroid.

  11. An Equivalent cross-section Framework for improving computational efficiency in Distributed Hydrologic Modelling

    NASA Astrophysics Data System (ADS)

    Khan, Urooj; Tuteja, Narendra; Ajami, Hoori; Sharma, Ashish

    2014-05-01

    While the potential uses and benefits of distributed catchment simulation models is undeniable, their practical usage is often hindered by the computational resources they demand. To reduce the computational time/effort in distributed hydrological modelling, a new approach of modelling over an equivalent cross-section is investigated where topographical and physiographic properties of first-order sub-basins are aggregated to constitute modelling elements. To formulate an equivalent cross-section, a homogenization test is conducted to assess the loss in accuracy when averaging topographic and physiographic variables, i.e. length, slope, soil depth and soil type. The homogenization test indicates that the accuracy lost in weighting the soil type is greatest, therefore it needs to be weighted in a systematic manner to formulate equivalent cross-sections. If the soil type remains the same within the sub-basin, a single equivalent cross-section is formulated for the entire sub-basin. If the soil type follows a specific pattern, i.e. different soil types near the centre of the river, middle of hillslope and ridge line, three equivalent cross-sections (left bank, right bank and head water) are required. If the soil types are complex and do not follow any specific pattern, multiple equivalent cross-sections are required based on the number of soil types. The equivalent cross-sections are formulated for a series of first order sub-basins by implementing different weighting methods of topographic and physiographic variables of landforms within the entire or part of a hillslope. The formulated equivalent cross-sections are then simulated using a 2-dimensional, Richards' equation based distributed hydrological model. The simulated fluxes are multiplied by the weighted area of each equivalent cross-section to calculate the total fluxes from the sub-basins. The simulated fluxes include horizontal flow, transpiration, soil evaporation, deep drainage and soil moisture. To assess the accuracy of equivalent cross-section approach, the sub-basins are also divided into equally spaced multiple hillslope cross-sections. These cross-sections are simulated in a fully distributed settings using the 2-dimensional, Richards' equation based distributed hydrological model. The simulated fluxes are multiplied by the contributing area of each cross-section to get total fluxes from each sub-basin referred as reference fluxes. The equivalent cross-section approach is investigated for seven first order sub-basins of the McLaughlin catchment of the Snowy River, NSW, Australia, and evaluated in Wagga-Wagga experimental catchment. Our results show that the simulated fluxes using an equivalent cross-section approach are very close to the reference fluxes whereas computational time is reduced of the order of ~4 to ~22 times in comparison to the fully distributed settings. The transpiration and soil evaporation are the dominant fluxes and constitute ~85% of actual rainfall. Overall, the accuracy achieved in dominant fluxes is higher than the other fluxes. The simulated soil moistures from equivalent cross-section approach are compared with the in-situ soil moisture observations in the Wagga-Wagga experimental catchment in NSW, and results found to be consistent. Our results illustrate that the equivalent cross-section approach reduces the computational time significantly while maintaining the same order of accuracy in predicting the hydrological fluxes. As a result, this approach provides a great potential for implementation of distributed hydrological models at regional scales.

  12. Exploring equivalence domain in nonlinear inverse problems using Covariance Matrix Adaption Evolution Strategy (CMAES) and random sampling

    NASA Astrophysics Data System (ADS)

    Grayver, Alexander V.; Kuvshinov, Alexey V.

    2016-05-01

    This paper presents a methodology to sample equivalence domain (ED) in nonlinear partial differential equation (PDE)-constrained inverse problems. For this purpose, we first applied state-of-the-art stochastic optimization algorithm called Covariance Matrix Adaptation Evolution Strategy (CMAES) to identify low-misfit regions of the model space. These regions were then randomly sampled to create an ensemble of equivalent models and quantify uncertainty. CMAES is aimed at exploring model space globally and is robust on very ill-conditioned problems. We show that the number of iterations required to converge grows at a moderate rate with respect to number of unknowns and the algorithm is embarrassingly parallel. We formulated the problem by using the generalized Gaussian distribution. This enabled us to seamlessly use arbitrary norms for residual and regularization terms. We show that various regularization norms facilitate studying different classes of equivalent solutions. We further show how performance of the standard Metropolis-Hastings Markov chain Monte Carlo algorithm can be substantially improved by using information CMAES provides. This methodology was tested by using individual and joint inversions of magneotelluric, controlled-source electromagnetic (EM) and global EM induction data.

  13. Comparison of alternative designs for reducing complex neurons to equivalent cables.

    PubMed

    Burke, R E

    2000-01-01

    Reduction of the morphological complexity of actual neurons into accurate, computationally efficient surrogate models is an important problem in computational neuroscience. The present work explores the use of two morphoelectrotonic transformations, somatofugal voltage attenuation (AT cables) and signal propagation delay (DL cables), as bases for construction of electrotonically equivalent cable models of neurons. In theory, the AT and DL cables should provide more accurate lumping of membrane regions that have the same transmembrane potential than the familiar equivalent cables that are based only on somatofugal electrotonic distance (LM cables). In practice, AT and DL cables indeed provided more accurate simulations of the somatic transient responses produced by fully branched neuron models than LM cables. This was the case in the presence of a somatic shunt as well as when membrane resistivity was uniform.

  14. Equivalent retarder-rotator approach to on-state twisted nematic liquid crystal displays

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Duran, Vicente; Lancis, Jesus; Tajahuerce, Enrique

    2006-06-01

    Polarization properties of a twisted nematic liquid crystal cell are fully characterized by an equivalent optical system that consists of a retarder wave plate and a rotator. In this paper we show that this result is of interest to optimize the light-modulation capabilities of a voltage-addressed liquid crystal display (LCD). We provide two examples. First, we demonstrate a calibration method that can be carried out by a standard polarimetric technique with a high degree of precision. Second, we propose an optical device to generate a family of equiazimuth polarization states by adding a quarter-wave plate to the LCD. We findmore » that the design procedure is best described in geometrical terms on the Poincare sphere by use of the equivalent model. Finally, laboratory results corresponding to a commercial LCD are presented.« less

  15. Issues of Qualification Assessment for Nurses in a Global Market.

    ERIC Educational Resources Information Center

    Wickett, Diane; McCutcheon, Helen

    2002-01-01

    Nursing shortages are creating a global market for nurses. However, assessment of qualifications varies widely among nations. In Australia, for example, overseas nurses must pass English language and nursing competency assessments. Issues of equivalence, cost, and time are involved. (Includes commentaries by Paula Kay Hancock and Abigail…

  16. Sample size allocation in multiregional equivalence studies.

    PubMed

    Liao, Jason J Z; Yu, Ziji; Li, Yulan

    2018-06-17

    With the increasing globalization of drug development, the multiregional clinical trial (MRCT) has gained extensive use. The data from MRCTs could be accepted by regulatory authorities across regions and countries as the primary sources of evidence to support global marketing drug approval simultaneously. The MRCT can speed up patient enrollment and drug approval, and it makes the effective therapies available to patients all over the world simultaneously. However, there are many challenges both operationally and scientifically in conducting a drug development globally. One of many important questions to answer for the design of a multiregional study is how to partition sample size into each individual region. In this paper, two systematic approaches are proposed for the sample size allocation in a multiregional equivalence trial. A numerical evaluation and a biosimilar trial are used to illustrate the characteristics of the proposed approaches. Copyright © 2018 John Wiley & Sons, Ltd.

  17. Global Magnetohydrodynamic Simulation Using High Performance FORTRAN on Parallel Computers

    NASA Astrophysics Data System (ADS)

    Ogino, T.

    High Performance Fortran (HPF) is one of modern and common techniques to achieve high performance parallel computation. We have translated a 3-dimensional magnetohydrodynamic (MHD) simulation code of the Earth's magnetosphere from VPP Fortran to HPF/JA on the Fujitsu VPP5000/56 vector-parallel supercomputer and the MHD code was fully vectorized and fully parallelized in VPP Fortran. The entire performance and capability of the HPF MHD code could be shown to be almost comparable to that of VPP Fortran. A 3-dimensional global MHD simulation of the earth's magnetosphere was performed at a speed of over 400 Gflops with an efficiency of 76.5 VPP5000/56 in vector and parallel computation that permitted comparison with catalog values. We have concluded that fluid and MHD codes that are fully vectorized and fully parallelized in VPP Fortran can be translated with relative ease to HPF/JA, and a code in HPF/JA may be expected to perform comparably to the same code written in VPP Fortran.

  18. Effective implementation of the weak Galerkin finite element methods for the biharmonic equation

    DOE PAGES

    Mu, Lin; Wang, Junping; Ye, Xiu

    2017-07-06

    The weak Galerkin (WG) methods have been introduced in [11, 12, 17] for solving the biharmonic equation. The purpose of this paper is to develop an algorithm to implement the WG methods effectively. This can be achieved by eliminating local unknowns to obtain a global system with significant reduction of size. In fact this reduced global system is equivalent to the Schur complements of the WG methods. The unknowns of the Schur complement of the WG method are those defined on the element boundaries. The equivalence of theWG method and its Schur complement is established. The numerical results demonstrate themore » effectiveness of this new implementation technique.« less

  19. Effective implementation of the weak Galerkin finite element methods for the biharmonic equation

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Mu, Lin; Wang, Junping; Ye, Xiu

    The weak Galerkin (WG) methods have been introduced in [11, 12, 17] for solving the biharmonic equation. The purpose of this paper is to develop an algorithm to implement the WG methods effectively. This can be achieved by eliminating local unknowns to obtain a global system with significant reduction of size. In fact this reduced global system is equivalent to the Schur complements of the WG methods. The unknowns of the Schur complement of the WG method are those defined on the element boundaries. The equivalence of theWG method and its Schur complement is established. The numerical results demonstrate themore » effectiveness of this new implementation technique.« less

  20. Inertia and Double Bending of Light from Equivalence

    NASA Technical Reports Server (NTRS)

    Shuler, Robert L., Jr.

    2010-01-01

    Careful examination of light paths in an accelerated reference frame, with use of Special Relativity, can account fully for the observed bending of light in a gravitational field, not just half of it as reported in 1911. This analysis also leads to a Machian formulation of inertia similar to the one proposed by Einstein in 1912 and later derived from gravitational field equations in Minkowsky Space by Sciama in 1953. There is a clear inference from equivalence that there is some type of inertial mass increase in a gravitational field. It is the purpose of the current paper to suggest that equivalence provides a more complete picture of gravitational effects than previously thought, correctly predicting full light bending, and that since the theory of inertia is derivable from equivalence, any theory based on equivalence must take account of it. Einstein himself clearly was not satisfied with the status of inertia in GRT, as our quotes have shown. Many have tried to account for inertia and met with less than success, for example Davidson s integration of Sciama s inertia into GRT but only for a steady state cosmology [10], and the Machian gravity theory of Brans and Dicke [11]. Yet Mach s idea hasn t gone away, and now it seems that it cannot go away without also disposing of equivalence.

  1. Exploring the Dynamics of Globalization: Supply Chain Vulnerability to Natural Disasters

    ERIC Educational Resources Information Center

    Kalafsky, Ronald V.; Conner, Neil

    2015-01-01

    Global supply chains play an increasingly important role in the economy and should therefore be addressed within geography coursework, especially given concerns that geographers have not fully explored various angles of globalization. This article explores the use of an online case study on supply chains and their vulnerability to natural…

  2. Global Learning and the School Curriculum

    ERIC Educational Resources Information Center

    Bourn, Douglas

    2016-01-01

    The global society of today is one that children and young people are aware of but this has not been fully recognised by education policy-makers despite the efforts and activities of many civil society organisations and the enthusiasm of teachers. Since 2010 in England, a government-sponsored programme, the Global Learning Programme, has been a…

  3. Applying machine learning to pattern analysis for automated in-design layout optimization

    NASA Astrophysics Data System (ADS)

    Cain, Jason P.; Fakhry, Moutaz; Pathak, Piyush; Sweis, Jason; Gennari, Frank; Lai, Ya-Chieh

    2018-04-01

    Building on previous work for cataloging unique topological patterns in an integrated circuit physical design, a new process is defined in which a risk scoring methodology is used to rank patterns based on manufacturing risk. Patterns with high risk are then mapped to functionally equivalent patterns with lower risk. The higher risk patterns are then replaced in the design with their lower risk equivalents. The pattern selection and replacement is fully automated and suitable for use for full-chip designs. Results from 14nm product designs show that the approach can identify and replace risk patterns with quantifiable positive impact on the risk score distribution after replacement.

  4. Reduced complexity structural modeling for automated airframe synthesis

    NASA Technical Reports Server (NTRS)

    Hajela, Prabhat

    1987-01-01

    A procedure is developed for the optimum sizing of wing structures based on representing the built-up finite element assembly of the structure by equivalent beam models. The reduced-order beam models are computationally less demanding in an optimum design environment which dictates repetitive analysis of several trial designs. The design procedure is implemented in a computer program requiring geometry and loading information to create the wing finite element model and its equivalent beam model, and providing a rapid estimate of the optimum weight obtained from a fully stressed design approach applied to the beam. The synthesis procedure is demonstrated for representative conventional-cantilever and joined wing configurations.

  5. Future Change of Snow Water Equivalent over Japan

    NASA Astrophysics Data System (ADS)

    Hara, M.; Kawase, H.; Kimura, F.; Fujita, M.; Ma, X.

    2012-12-01

    Western side of Honshu Island and Hokkaido Island in Japan are ones of the heaviest snowfall areas in the world. Although a heavy snowfall often brings disaster, snow is one of the major sources for agriculture, industrial, and house-use in Japan. Even during the winter, the monthly mean of the surface air temperature often exceeds 0 C in large parts of the heavy snow areas along the Sea of Japan. Thus, snow cover may be seriously reduced in these areas as a result of the global warming, which is caused by an increase in greenhouse gases. The change in seasonal march of snow water equivalent, e.g., snowmelt season and amount will strongly influence to social-economic activities. We performed a series of numerical experiments including present and future climate simulations and much-snow and less-snow cases using a regional climate model. Pseudo-Global-Warming (PGW) method (Kimura and Kitoh, 2008) is applied for the future climate simulations. MIROC 3.2 medres 2070s output under IPCC SRES A2 scenario and 1990s output under 20c3m scenario used for PGW method. The precipitation, snow depth, and surface air temperature of the hindcast simulations show good agreement with the AMeDAS station data. In much-snow cases, The decreasing rate of maximum total snow water equivalent over Japan due to climate change was 49%. Main cause of the decrease of the total snow water equivalent is the air temperature rise due to global climate change. The difference in the precipitation amount between the present and the future simulations is small.

  6. A global dataset of sub-daily rainfall indices

    NASA Astrophysics Data System (ADS)

    Fowler, H. J.; Lewis, E.; Blenkinsop, S.; Guerreiro, S.; Li, X.; Barbero, R.; Chan, S.; Lenderink, G.; Westra, S.

    2017-12-01

    It is still uncertain how hydrological extremes will change with global warming as we do not fully understand the processes that cause extreme precipitation under current climate variability. The INTENSE project is using a novel and fully-integrated data-modelling approach to provide a step-change in our understanding of the nature and drivers of global precipitation extremes and change on societally relevant timescales, leading to improved high-resolution climate model representation of extreme rainfall processes. The INTENSE project is in conjunction with the World Climate Research Programme (WCRP)'s Grand Challenge on 'Understanding and Predicting Weather and Climate Extremes' and the Global Water and Energy Exchanges Project (GEWEX) Science questions. A new global sub-daily precipitation dataset has been constructed (data collection is ongoing). Metadata for each station has been calculated, detailing record lengths, missing data, station locations. A set of global hydroclimatic indices have been produced based upon stakeholder recommendations including indices that describe maximum rainfall totals and timing, the intensity, duration and frequency of storms, frequency of storms above specific thresholds and information about the diurnal cycle. This will provide a unique global data resource on sub-daily precipitation whose derived indices will be freely available to the wider scientific community.

  7. Towards a Fine-Resolution Global Coupled Climate System for Prediction on Decadal/Centennial Scales

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    McClean, Julie L.

    The over-arching goal of this project was to contribute to the realization of a fully coupled fine resolution Earth System Model simulation in which a weather-scale atmosphere is coupled to an ocean in which mesoscale eddies are largely resolved. Both a prototype fine-resolution fully coupled ESM simulation and a first-ever multi-decadal forced fine-resolution global coupled ocean/ice simulation were configured, tested, run, and analyzed as part of this grant. Science questions focused on the gains from the use of high horizontal resolution, particularly in the ocean and sea-ice, with respect to climatically important processes. Both these fine resolution coupled ocean/sea icemore » and fully-coupled simulations and precedent stand-alone eddy-resolving ocean and eddy-permitting coupled ocean/ice simulations were used to explore the high resolution regime. Overall, these studies showed that the presence of mesoscale eddies significantly impacted mixing processes and the global meridional overturning circulation in the ocean simulations. Fourteen refereed publications and a Ph.D. dissertation resulted from this grant.« less

  8. Renewable Energy Capability vs. Climate Necessity

    ERIC Educational Resources Information Center

    Mills, David

    2006-01-01

    A 450-ppm equivalent CO[2] target by 2050 is an often-proposed goal under a future global emissions agreement, but there is considerable high side risk in global-warming models due to cloud formation, feedbacks in dissolved organic carbon from peat bogs in polar regions, and unaccounted solar dimming by particulates. The 450-ppm figure is…

  9. An automated system for global atmospheric sampling using B-747 airliners

    NASA Technical Reports Server (NTRS)

    Lew, K. Q.; Gustafsson, U. R. C.; Johnson, R. E.

    1981-01-01

    The global air sampling program utilizes commercial aircrafts in scheduled service to measure atmospheric constituents. A fully automated system designed for the 747 aircraft is described. Airline operational constraints and data and control subsystems are treated. The overall program management, system monitoring, and data retrieval from four aircraft in global service is described.

  10. A hypothesis for Proterozoic-Phanerozoic supercontinent cyclicity, with implications for mantle convection, plate tectonics and Earth system evolution

    NASA Astrophysics Data System (ADS)

    Grenholm, Mikael; Scherstén, Anders

    2015-11-01

    We present a conceptual model for supercontinent cycles in the Proterozoic-Phanerozoic Eons. It is based on the repetitive behavior of C and Sr isotopes in marine carbonates and U-Pb ages and εHf of detrital zircons seen during the Neoproterozoic-Paleozoic and Paleoproterozoic Eras, respectively. These records are considered to reflect secular changes in global tectonics, and it is hypothesized that the repetitive pattern is caused by the same type of changes in global tectonics. The fundamental premise of this paper is that such repetitive changes should also be recorded in orogenic belts worldwide. This carries the implication that Neoproterozoic-Paleozoic orogenic belts should have Paleoproterozoic equivalents. It is proposed that this is the case for the East African, Uralides and Ouachita-Alleghanian orogens, which have Paleoproterozoic analogs in the West African-Amazon, Laurentian and East European cratons, respectively. The Neoproterozoic-Paleozoic orogenic belts are not isolated features but occur in a specific global context, which correspond to the relatively well-constrained Neoproterozoic break-up of Rodinia, and the subsequent Late Paleozoic assembly of Pangea. The existence of Paleoproterozoic equivalents to Neoproterozoic-Paleozoic orogens requires that the same cycle defined the Paleoproterozoic. We therefore hypothesize that there were Paleoproterozoic supercontinents equivalent to Rodinia and Pangea, and that Proterozoic-Phanerozoic supercontinents are comprised of two basic types of configurations, equivalent to Rodinia (R-type) and Pangea (P-type). The Paleoproterozoic equivalent of Rodinia is likely the first supercontinent to have formed, and Proterozoic-Phanerozoic supercontinent cycles are therefore defined by R- to R-type cycles, each lasting approximately 1.5 Gyr. We use this cyclic pattern as a framework to develop a conceptual model that predicts the configuration and cycles of Proterozoic-Phanerozoic supercontinents, and their relation to mantle convection and Earth system evolution.

  11. Toward textbook multigrid efficiency for fully implicit resistive magnetohydrodynamics

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Adams, Mark F.; Samtaney, Ravi, E-mail: samtaney@pppl.go; Brandt, Achi

    2010-09-01

    Multigrid methods can solve some classes of elliptic and parabolic equations to accuracy below the truncation error with a work-cost equivalent to a few residual calculations - so-called 'textbook' multigrid efficiency. We investigate methods to solve the system of equations that arise in time dependent magnetohydrodynamics (MHD) simulations with textbook multigrid efficiency. We apply multigrid techniques such as geometric interpolation, full approximate storage, Gauss-Seidel smoothers, and defect correction for fully implicit, nonlinear, second-order finite volume discretizations of MHD. We apply these methods to a standard resistive MHD benchmark problem, the GEM reconnection problem, and add a strong magnetic guide field,more » which is a critical characteristic of magnetically confined fusion plasmas. We show that our multigrid methods can achieve near textbook efficiency on fully implicit resistive MHD simulations.« less

  12. Toward textbook multigrid efficiency for fully implicit resistive magnetohydrodynamics

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Adams, Mark F.; Samtaney, Ravi; Brandt, Achi

    2010-09-01

    Multigrid methods can solve some classes of elliptic and parabolic equations to accuracy below the truncation error with a work-cost equivalent to a few residual calculations – so-called ‘‘textbook” multigrid efficiency. We investigate methods to solve the system of equations that arise in time dependent magnetohydrodynamics (MHD) simulations with textbook multigrid efficiency. We apply multigrid techniques such as geometric interpolation, full approximate storage, Gauss–Seidel smoothers, and defect correction for fully implicit, nonlinear, second-order finite volume discretizations of MHD. We apply these methods to a standard resistive MHD benchmark problem, the GEM reconnection problem, and add a strong magnetic guide field,more » which is a critical characteristic of magnetically confined fusion plasmas. We show that our multigrid methods can achieve near textbook efficiency on fully implicit resistive MHD simulations.« less

  13. Toward textbook multigrid efficiency for fully implicit resistive magnetohydrodynamics

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Adams, Mark F.; Samtaney, Ravi; Brandt, Achi

    2013-12-14

    Multigrid methods can solve some classes of elliptic and parabolic equations to accuracy below the truncation error with a work-cost equivalent to a few residual calculations – so-called “textbook” multigrid efficiency. We investigate methods to solve the system of equations that arise in time dependent magnetohydrodynamics (MHD) simulations with textbook multigrid efficiency. We apply multigrid techniques such as geometric interpolation, full approximate storage, Gauss-Seidel smoothers, and defect correction for fully implicit, nonlinear, second-order finite volume discretizations of MHD. We apply these methods to a standard resistive MHD benchmark problem, the GEM reconnection problem, and add a strong magnetic guide field,more » which is a critical characteristic of magnetically confined fusion plasmas. We show that our multigrid methods can achieve near textbook efficiency on fully implicit resistive MHD simulations.« less

  14. Optimum structural sizing of conventional cantilever and joined wing configurations using equivalent beam models

    NASA Technical Reports Server (NTRS)

    Hajela, P.; Chen, J. L.

    1986-01-01

    The present paper describes an approach for the optimum sizing of single and joined wing structures that is based on representing the built-up finite element model of the structure by an equivalent beam model. The low order beam model is computationally more efficient in an environment that requires repetitive analysis of several trial designs. The design procedure is implemented in a computer program that requires geometry and loading data typically available from an aerodynamic synthesis program, to create the finite element model of the lifting surface and an equivalent beam model. A fully stressed design procedure is used to obtain rapid estimates of the optimum structural weight for the beam model for a given geometry, and a qualitative description of the material distribution over the wing structure. The synthesis procedure is demonstrated for representative single wing and joined wing structures.

  15. Equivalency principle for magnetoelectroelastic multiferroics with arbitrary microstructure: The phase field approach

    NASA Astrophysics Data System (ADS)

    Ni, Yong; He, Linghui; Khachaturyan, Armen G.

    2010-07-01

    A phase field method is proposed to determine the equilibrium fields of a magnetoelectroelastic multiferroic with arbitrarily distributed constitutive constants under applied loadings. This method is based on a developed generalized Eshelby's equivalency principle, in which the elastic strain, electrostatic, and magnetostatic fields at the equilibrium in the original heterogeneous system are exactly the same as those in an equivalent homogeneous magnetoelectroelastic coupled or uncoupled system with properly chosen distributed effective eigenstrain, polarization, and magnetization fields. Finding these effective fields fully solves the equilibrium elasticity, electrostatics, and magnetostatics in the original heterogeneous multiferroic. The paper formulates a variational principle proving that the effective fields are minimizers of appropriate close-form energy functional. The proposed phase field approach produces the energy minimizing effective fields (and thus solving the general multiferroic problem) as a result of artificial relaxation process described by the Ginzburg-Landau-Khalatnikov kinetic equations.

  16. The Equivalent Thermal Resistance of Tile Roofs with and without Batten Systems

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Miller, William A

    Clay and concrete tile roofs were installed on a fully instrumented attic test facility operating in East Tennessee s climate. Roof, attic and deck temperatures and heat flows were recorded for each of the tile roofs and also on an adjacent attic cavity covered with a conventionally pigmented and direct-nailed asphalt shingle roof. The data were used to benchmark a computer tool for simulation of roofs and attics and the tool used to develop an approach for computing an equivalent seasonal R-value for sub-tile venting. The approach computed equal heat fluxes through the ceilings of roofs having different combinations ofmore » surface radiation properties and or building constructions. A direct nailed shingle roof served as a control for estimating the equivalent thermal resistance of the air space. Simulations were benchmarked to data in the ASHRAE Fundamentals for the thermal resistance of inclined and closed air spaces.« less

  17. 49 CFR 192.112 - Additional design requirements for steel pipe using alternative maximum allowable operating...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ..., fully killed, continuously cast steel with calcium treatment. (2) The carbon equivalents of the steel... under this section. (b) Fracture control (1) The toughness properties for pipe must address the... specification level 2 or ASME B31.8 (incorporated by reference, see § 192.7). (2) Fracture control must: (i...

  18. 49 CFR 192.112 - Additional design requirements for steel pipe using alternative maximum allowable operating...

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ..., fully killed, continuously cast steel with calcium treatment. (2) The carbon equivalents of the steel... under this section. (b) Fracture control (1) The toughness properties for pipe must address the... specification level 2 or ASME B31.8 (incorporated by reference, see § 192.7). (2) Fracture control must: (i...

  19. 49 CFR 192.112 - Additional design requirements for steel pipe using alternative maximum allowable operating...

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ..., fully killed, continuously cast steel with calcium treatment. (2) The carbon equivalents of the steel... under this section. (b) Fracture control (1) The toughness properties for pipe must address the... specification level 2 or ASME B31.8 (incorporated by reference, see § 192.7). (2) Fracture control must: (i...

  20. 49 CFR 192.112 - Additional design requirements for steel pipe using alternative maximum allowable operating...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ..., fully killed, continuously cast steel with calcium treatment. (2) The carbon equivalents of the steel... under this section. (b) Fracture control (1) The toughness properties for pipe must address the... specification level 2 or ASME B31.8 (incorporated by reference, see § 192.7). (2) Fracture control must: (i...

  1. 49 CFR 192.112 - Additional design requirements for steel pipe using alternative maximum allowable operating...

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ..., fully killed, continuously cast steel with calcium treatment. (2) The carbon equivalents of the steel... under this section. (b) Fracture control (1) The toughness properties for pipe must address the... specification level 2 or ASME B31.8 (incorporated by reference, see § 192.7). (2) Fracture control must: (i...

  2. Particle swarm optimization and its application in MEG source localization using single time sliced data

    NASA Astrophysics Data System (ADS)

    Lin, Juan; Liu, Chenglian; Guo, Yongning

    2014-10-01

    The estimation of neural active sources from the magnetoencephalography (MEG) data is a very critical issue for both clinical neurology and brain functions research. A widely accepted source-modeling technique for MEG involves calculating a set of equivalent current dipoles (ECDs). Depth in the brain is one of difficulties in MEG source localization. Particle swarm optimization(PSO) is widely used to solve various optimization problems. In this paper we discuss its ability and robustness to find the global optimum in different depths of the brain when using single equivalent current dipole (sECD) model and single time sliced data. The results show that PSO is an effective global optimization to MEG source localization when given one dipole in different depths.

  3. Fully automatic time-window selection using machine learning for global adjoint tomography

    NASA Astrophysics Data System (ADS)

    Chen, Y.; Hill, J.; Lei, W.; Lefebvre, M. P.; Bozdag, E.; Komatitsch, D.; Tromp, J.

    2017-12-01

    Selecting time windows from seismograms such that the synthetic measurements (from simulations) and measured observations are sufficiently close is indispensable in a global adjoint tomography framework. The increasing amount of seismic data collected everyday around the world demands "intelligent" algorithms for seismic window selection. While the traditional FLEXWIN algorithm can be "automatic" to some extent, it still requires both human input and human knowledge or experience, and thus is not deemed to be fully automatic. The goal of intelligent window selection is to automatically select windows based on a learnt engine that is built upon a huge number of existing windows generated through the adjoint tomography project. We have formulated the automatic window selection problem as a classification problem. All possible misfit calculation windows are classified as either usable or unusable. Given a large number of windows with a known selection mode (select or not select), we train a neural network to predict the selection mode of an arbitrary input window. Currently, the five features we extract from the windows are its cross-correlation value, cross-correlation time lag, amplitude ratio between observed and synthetic data, window length, and minimum STA/LTA value. More features can be included in the future. We use these features to characterize each window for training a multilayer perceptron neural network (MPNN). Training the MPNN is equivalent to solve a non-linear optimization problem. We use backward propagation to derive the gradient of the loss function with respect to the weighting matrices and bias vectors and use the mini-batch stochastic gradient method to iteratively optimize the MPNN. Numerical tests show that with a careful selection of the training data and a sufficient amount of training data, we are able to train a robust neural network that is capable of detecting the waveforms in an arbitrary earthquake data with negligible detection error compared to existing selection methods (e.g. FLEXWIN). We will introduce in detail the mathematical formulation of the window-selection-oriented MPNN and show very encouraging results when applying the new algorithm to real earthquake data.

  4. Embryology training for Reproductive Endocrine fellows in the clinical human embryology laboratory.

    PubMed

    Scott, Richard T; Hong, Kathleen H; Werner, Marie D; Forman, Eric J; Ruiz, Andrew; Cheng, Michael C; Zhao, Tian; Upham, Kathleen M

    2014-04-01

    To determine if comprehensive embryology training for clinical Reproductive Endocrinology fellows could be completed to a level of proficiency equivalent to that of experienced embryologists. Clinical fellows were integrated into the clinical embryology team and were trained to perform all the various procedures utilized in clinical embryology. The fellows were trained to the same standards as the clinical embryology staff and underwent the same certification and sign off procedures. To determine if inclusion of clinical fellows on the embryology team impacted outcomes, outcomes for individual oocytes/embryos and the clinical cases where the fellows perform embryology procedures were compared to the outcomes of those oocytes/embryos and cases performed by the full time embryology staff. Clinical procedures performed by the fellows included isolation and processing of oocytes following retrieval, loading catheters for embryo transfer, and vitrification (N = 823 cases). Micromanipulation procedures compared included ICSI and assisted hatching (N = 650 cases). For each procedure, the outcomes in those cases performed by the RE fellows were equivalent to those done by the fully trained clinical embryology staff. When fellows are trained to perform embryology procedures as an integral part of their fellowship curricula, laboratory efficiencies and clinical outcomes are fully maintained. This experience provides valuable insight into the ART process critical to this subspecialty. It also empowers fellows to fully participate in research relating to the viability of gamete and embryos and optimization of the clinical ART laboratory.

  5. Flattening Property and the Existence of Global Attractors in Banach Space

    NASA Astrophysics Data System (ADS)

    Aris, Naimah; Maharani, Sitti; Jusmawati, Massalesse; Nurwahyu, Budi

    2018-03-01

    This paper analyses the existence of global attractor in infinite dimensional system using flattening property. The earlier stage we show the existence of the global attractor in complete metric space by using concept of the ω-limit compact concept with measure of non-compactness methods. Then we show that the ω-limit compact concept is equivalent with the flattening property in Banach space. If we can prove there exist an absorbing set in the system and the flattening property holds, then the global attractor exist in the system.

  6. The variability of atmospheric equivalent temperature for radar altimeter range correction

    NASA Technical Reports Server (NTRS)

    Liu, W. Timothy; Mock, Donald

    1990-01-01

    Two sets of data were used to test the validity of the presently used approximation for radar altimeter range correction due to atmospheric water vapor. The approximation includes an assumption of constant atmospheric equivalent temperature. The first data set includes monthly, three-dimensional, gridded temperature and humidity fields over global oceans for a 10-year period, and the second is comprised of daily or semidaily rawinsonde data at 17 island stations for a 7-year period. It is found that the standard method underestimates the variability of the equivalent temperature, and the approximation could introduce errors of 2 cm for monthly means. The equivalent temperature is found to have a strong meridional gradient, and the highest temporal variabilities are found over western boundary currents. The study affirms that the atmospheric water vapor is a good predictor for both the equivalent temperature and the range correction. A relation is proposed to reduce the error.

  7. A Comparison of Satellite-Derived Snow Maps with a Focus on Ephemeral Snow in North Carolina

    NASA Technical Reports Server (NTRS)

    Hall, Dorothy K.; Fuhrmann, Christopher M.; Perry, L. Baker; Riggs, George A.; Robinson, David A.; Foster, James L.

    2010-01-01

    In this paper, we focus on the attributes and limitations of four commonly-used daily snowcover products with respect to their ability to map ephemeral snow in central and eastern North Carolina. We show that the Moderate-Resolution Imaging Spectroradiometer (MODIS) fractional snow-cover maps can delineate the snow-covered area very well through the use of a fully-automated algorithm, but suffer from the limitation that cloud cover precludes mapping some ephemeral snow. The semi-automated Interactive Multi-sensor Snow and ice mapping system (IMS) and Rutgers Global Snow Lab (GSL) snow maps are often able to capture ephemeral snow cover because ground-station data are employed to develop the snow maps, The Rutgers GSL maps are based on the IMS maps. Finally, the Advanced Microwave Scanning Radiometer for EOS (AMSR-E) provides some good detail of snow-water equivalent especially in deeper snow, but may miss ephemeral snow cover because it is often very thin or wet; the AMSR-E maps also suffer from coarse spatial resolution. We conclude that the southeastern United States represents a good test region for validating the ability of satellite snow-cover maps to capture ephemeral snow cover,

  8. Progressive transmission of secured images with authentication using decompositions into monovariate functions

    NASA Astrophysics Data System (ADS)

    Leni, Pierre-Emmanuel; Fougerolle, Yohan D.; Truchetet, Frédéric

    2014-05-01

    We propose a progressive transmission approach of an image authenticated using an overlapping subimage that can be removed to restore the original image. Our approach is different from most visible watermarking approaches that allow one to later remove the watermark, because the mark is not directly introduced in the two-dimensional image space. Instead, it is rather applied to an equivalent monovariate representation of the image. Precisely, the approach is based on our progressive transmission approach that relies on a modified Kolmogorov spline network, and therefore inherits its advantages: resilience to packet losses during transmission and support of heterogeneous display environments. The marked image can be accessed at any intermediate resolution, and a key is needed to remove the mark to fully recover the original image without loss. Moreover, the key can be different for every resolution, and the images can be globally restored in case of packet losses during the transmission. Our contributions lie in the proposition of decomposing a mark (an overlapping image) and an image into monovariate functions following the Kolmogorov superposition theorem; and in the combination of these monovariate functions to provide a removable visible "watermarking" of images with the ability to restore the original image using a key.

  9. Halal and kosher slaughter methods and meat quality: a review.

    PubMed

    Farouk, M M; Al-Mazeedi, H M; Sabow, A B; Bekhit, A E D; Adeyemi, K D; Sazili, A Q; Ghani, A

    2014-11-01

    There are many slaughter procedures that religions and cultures use around the world. The two that are commercially relevant are the halal and kosher methods practiced by Muslims and Jews respectively. The global trade in red meat and poultry produced using these two methods is substantial, thus the importance of the quality of the meat produced using the methods. Halal and kosher slaughter per se should not affect meat quality more than their industrial equivalents, however, some of their associated pre- and post-slaughter processes do. For instance, the slow decline in blood pressure following a halal pre-slaughter head-only stun and neck cut causes blood splash (ecchymosis) in a range of muscles and organs of slaughtered livestock. Other quality concerns include bruising, hemorrhages, skin discoloration and broken bones particularly in poultry. In addition to these conventional quality issues, the "spiritual quality" of the meat can also be affected when the halal and kosher religious requirements are not fully met during the slaughter process. The nature, causes, importance and mitigations of these and other quality issues related to halal and kosher slaughtering and meat production using these methods are the subjects of this review. Copyright © 2014 Elsevier Ltd. All rights reserved.

  10. Design and economics of a photovoltaic concentrator array for off-grid applications

    NASA Astrophysics Data System (ADS)

    Maish, A. B.; Rios, M., Jr.

    1982-09-01

    The array design and expected operation of a photovoltaic concentrator are discussed. A second generation stand alone 680 W/sub p/ photovoltaic (PV) concentrating array for low power, nongrid connected applications was designed. The array consists of six passive cooled point focus Fresnel lens concentrating modules on a two axis polar mount tracking structure. The new array design incorporates several major improvements to the first generation design. These include 50% more array area and a control system which allows unattended, fully automatic operation. The life cycle energy costs are calculated and compared to the equivalent energy costs of a 3 kW diesel electric generator set and an equivalent flat panel PV system.

  11. The fully differential top decay distribution

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Aguilar-Saavedra, J. A.; Boudreau, J.; Escobar, C.

    We write down the four-dimensional fully differential decay distribution for the top quark decay t → Wb → ℓνb. We discuss how its eight physical parameters can be measured, either with a global fit or with the use of selected one-dimensional distributions and asymmetries. We give expressions for the top decay amplitudes for a general tbW interaction, and show how the untangled measurement of the two components of the fraction of longitudinal W bosons – those with b quark helicities of 1/2 and –1/2, respectively – could improve the precision of a global fit to the tbW vertex.

  12. The fully differential top decay distribution

    DOE PAGES

    Aguilar-Saavedra, J. A.; Boudreau, J.; Escobar, C.; ...

    2017-03-29

    We write down the four-dimensional fully differential decay distribution for the top quark decay t → Wb → ℓνb. We discuss how its eight physical parameters can be measured, either with a global fit or with the use of selected one-dimensional distributions and asymmetries. We give expressions for the top decay amplitudes for a general tbW interaction, and show how the untangled measurement of the two components of the fraction of longitudinal W bosons – those with b quark helicities of 1/2 and –1/2, respectively – could improve the precision of a global fit to the tbW vertex.

  13. A Variational Reduction and the Existence of a Fully Localised Solitary Wave for the Three-Dimensional Water-Wave Problem with Weak Surface Tension

    NASA Astrophysics Data System (ADS)

    Buffoni, Boris; Groves, Mark D.; Wahlén, Erik

    2017-12-01

    Fully localised solitary waves are travelling-wave solutions of the three- dimensional gravity-capillary water wave problem which decay to zero in every horizontal spatial direction. Their existence has been predicted on the basis of numerical simulations and model equations (in which context they are usually referred to as `lumps'), and a mathematically rigorous existence theory for strong surface tension (Bond number {β} greater than {1/3} ) has recently been given. In this article we present an existence theory for the physically more realistic case {0 < β < 1/3} . A classical variational principle for fully localised solitary waves is reduced to a locally equivalent variational principle featuring a perturbation of the functional associated with the Davey-Stewartson equation. A nontrivial critical point of the reduced functional is found by minimising it over its natural constraint set.

  14. A Variational Reduction and the Existence of a Fully Localised Solitary Wave for the Three-Dimensional Water-Wave Problem with Weak Surface Tension

    NASA Astrophysics Data System (ADS)

    Buffoni, Boris; Groves, Mark D.; Wahlén, Erik

    2018-06-01

    Fully localised solitary waves are travelling-wave solutions of the three- dimensional gravity-capillary water wave problem which decay to zero in every horizontal spatial direction. Their existence has been predicted on the basis of numerical simulations and model equations (in which context they are usually referred to as `lumps'), and a mathematically rigorous existence theory for strong surface tension (Bond number {β} greater than {1/3}) has recently been given. In this article we present an existence theory for the physically more realistic case {0 < β < 1/3}. A classical variational principle for fully localised solitary waves is reduced to a locally equivalent variational principle featuring a perturbation of the functional associated with the Davey-Stewartson equation. A nontrivial critical point of the reduced functional is found by minimising it over its natural constraint set.

  15. Generalized Causal Quantum Theories

    NASA Astrophysics Data System (ADS)

    Parmeggiani, Claudio

    2007-12-01

    We shall show that is always possible to construct causal Quantum Theories fully equivalent (as predictive tools) to acausal, standard Quantum Theory, relativistic or not relativistic; we re-obtain, as a particular case, the usual Quantum Bohmian Theory. Then we consider the measurement process, in causal theories, and we conclude that the state of affairs is not really improved, with respect to standard theories.

  16. Amorphous MoS3 as the sulfur-equivalent cathode material for room-temperature Li-S and Na-S batteries.

    PubMed

    Ye, Hualin; Ma, Lu; Zhou, Yu; Wang, Lu; Han, Na; Zhao, Feipeng; Deng, Jun; Wu, Tianpin; Li, Yanguang; Lu, Jun

    2017-12-12

    Many problems associated with Li-S and Na-S batteries essentially root in the generation of their soluble polysulfide intermediates. While conventional wisdom mainly focuses on trapping polysulfides at the cathode using various functional materials, few strategies are available at present to fully resolve or circumvent this long-standing issue. In this study, we propose the concept of sulfur-equivalent cathode materials, and demonstrate the great potential of amorphous MoS 3 as such a material for room-temperature Li-S and Na-S batteries. In Li-S batteries, MoS 3 exhibits sulfur-like behavior with large reversible specific capacity, excellent cycle life, and the possibility to achieve high areal capacity. Most remarkably, it is also fully cyclable in the carbonate electrolyte under a relatively high temperature of 55 °C. MoS 3 can also be used as the cathode material of even more challenging Na-S batteries to enable decent capacity and good cycle life. Operando X-ray absorption spectroscopy (XAS) experiments are carried out to track the structural evolution of MoS 3 It largely preserves its chain-like structure during repetitive battery cycling without generating any free polysulfide intermediates.

  17. Amorphous MoS3 as the sulfur-equivalent cathode material for room-temperature Li–S and Na–S batteries

    PubMed Central

    Ye, Hualin; Ma, Lu; Zhou, Yu; Wang, Lu; Han, Na; Zhao, Feipeng; Deng, Jun; Wu, Tianpin; Li, Yanguang; Lu, Jun

    2017-01-01

    Many problems associated with Li–S and Na–S batteries essentially root in the generation of their soluble polysulfide intermediates. While conventional wisdom mainly focuses on trapping polysulfides at the cathode using various functional materials, few strategies are available at present to fully resolve or circumvent this long-standing issue. In this study, we propose the concept of sulfur-equivalent cathode materials, and demonstrate the great potential of amorphous MoS3 as such a material for room-temperature Li–S and Na–S batteries. In Li–S batteries, MoS3 exhibits sulfur-like behavior with large reversible specific capacity, excellent cycle life, and the possibility to achieve high areal capacity. Most remarkably, it is also fully cyclable in the carbonate electrolyte under a relatively high temperature of 55 °C. MoS3 can also be used as the cathode material of even more challenging Na–S batteries to enable decent capacity and good cycle life. Operando X-ray absorption spectroscopy (XAS) experiments are carried out to track the structural evolution of MoS3. It largely preserves its chain-like structure during repetitive battery cycling without generating any free polysulfide intermediates. PMID:29180431

  18. A Prospective, Matched Comparison Study of SUV Measurements From Time-of-Flight Versus Non-Time-of-Flight PET/CT Scanners.

    PubMed

    Thompson, Holly M; Minamimoto, Ryogo; Jamali, Mehran; Barkhodari, Amir; von Eyben, Rie; Iagaru, Andrei

    2016-07-01

    As quantitative F-FDG PET numbers and pooling of results from different PET/CT scanners become more influential in the management of patients, it becomes imperative that we fully interrogate differences between scanners to fully understand the degree of scanner bias on the statistical power of studies. Participants with body mass index (BMI) greater than 25, scheduled on a time-of-flight (TOF)-capable PET/CT scanner, had a consecutive scan on a non-TOF-capable PET/CT scanner and vice versa. SUVmean in various tissues and SUVmax of malignant lesions were measured from both scans, matched to each subject. Data were analyzed using a mixed-effects model, and statistical significance was determined using equivalence testing, with P < 0.05 being significant. Equivalence was established in all baseline organs, except the cerebellum, matched per patient between scanner types. Mixed-effects method analysis of lesions, repeated between scan types and matched per patient, demonstrated good concordance between scanner types. Patients could be scanned on either a TOF or non-TOF-capable PET/CT scanner without clinical compromise to quantitative SUV measurements.

  19. Optically transparent microwave screens based on engineered graphene layers.

    PubMed

    Grande, M; Bianco, G V; Vincenti, M A; de Ceglia, D; Capezzuto, P; Petruzzelli, V; Scalora, M; Bruno, G; D'Orazio, A

    2016-10-03

    We propose an innovative approach for the realization of a microwave absorber fully transparent in the optical regime. This device is based on the Salisbury screen configuration, which consists of a lossless spacer, sandwiched between two graphene sheets whose sheet resistances are different and properly engineered. Experimental results show that it is possible to achieve near-perfect electromagnetic absorption in the microwave X-band. These findings are fully supported by an analytical approach based on an equivalent circuital model. Engineering and integration of graphene sheets could facilitate the realization of innovative microwave absorbers with additional electromagnetic and optical functionalities that could circumvent some of the major limitations of opaque microwave absorbers.

  20. Exact closed-form solutions of a fully nonlinear asymptotic two-fluid model

    NASA Astrophysics Data System (ADS)

    Cheviakov, Alexei F.

    2018-05-01

    A fully nonlinear model of Choi and Camassa (1999) describing one-dimensional incompressible dynamics of two non-mixing fluids in a horizontal channel, under a shallow water approximation, is considered. An equivalence transformation is presented, leading to a special dimensionless form of the system, involving a single dimensionless constant physical parameter, as opposed to five parameters present in the original model. A first-order dimensionless ordinary differential equation describing traveling wave solutions is analyzed. Several multi-parameter families of physically meaningful exact closed-form solutions of the two-fluid model are derived, corresponding to periodic, solitary, and kink-type bidirectional traveling waves; specific examples are given, and properties of the exact solutions are analyzed.

  1. Recycling of metals: accounting of greenhouse gases and global warming contributions.

    PubMed

    Damgaard, Anders; Larsen, Anna W; Christensen, Thomas H

    2009-11-01

    Greenhouse gas (GHG) emissions related to recycling of metals in post-consumer waste are assessed from a waste management perspective; here the material recovery facility (MRF), for the sorting of the recovered metal. The GHG accounting includes indirect upstream emissions, direct activities at the MRF as well as indirect downstream activities in terms of reprocessing of the metal scrap and savings in terms of avoided production of virgin metal. The global warming factor (GWF) shows that upstream activities and the MRF causes negligible GHG emissions (12.8 to 52.6 kg CO(2)-equivalents tonne(-1) recovered metal) compared to the reprocessing of the metal itself (360-1260 kg CO(2)-equivalents tonne(-1) of recovered aluminium and 400- 1020 kg CO(2)-equivalents tonne(- 1) of recovered steel).The reprocessing is however counterbalanced by large savings of avoided virgin production of steel and aluminium. The net downstream savings were found to be 5040-19 340 kg CO(2)-equivalents tonne(-1) of treated aluminium and 560-2360 kg CO(2)-equivalents tonne(-1) of treated steel. Due to the huge differences in reported data it is hard to compare general data on the recovery of metal scrap as they are very dependent on the technology and data choices. Furthermore, the energy used in both the recovery process as well as the avoided primary production is crucial. The range of avoided impact shows that recovery of metals will always be beneficial over primary production, due to the high energy savings, and that the GHG emissions associated with the sorting of metals are negligible.

  2. Global reduced mechanisms for methane and hydrogen combustion with nitric oxide formation constructed with CSP data

    NASA Astrophysics Data System (ADS)

    Massias, A.; Diamantis, D.; Mastorakos, E.; Goussis, D. A.

    1999-06-01

    Reduced mechanisms for methane-air and hydrogen-air combustion including NO formation have been constructed with the computational singular perturbation (CSP) method using the fully automated algorithm described by Massias et al. The analysis was performed on solutions of unstrained adiabatic premixed flames with detailed chemical kinetics described by GRI 2.11 for methane and a 71-reaction mechanism for hydrogen including NOx formation. A 10-step reduced mechanism for methane has been constructed which reproduces accurately laminar burning velocities, flame temperatures and mass fraction distributions of major species for the whole flammability range. Many steady-state species are also predicted satisfactorily. This mechanism is an improvement over the seven-step set of Massias et al, especially for rich flames, because the use of HCNO, HCN and C2H2 as major species results in a better calculation of prompt NO. The present 10-step mechanism may thus also be applicable to diffusion flames. A five-step mechanism for lean and hydrogen-rich combustion has also been constructed based on a detailed mechanism including thermal NO. This mechanism is accurate for a wide range of the equivalence ratio and for pressures as high as 40 bar. For both fuels, the CSP algorithm automatically pointed to the same steady-state species as those identified by laborious analysis or intuition in the literature and the global reactions were similar to well established previous methane-reduced mechanisms. This implies that the method is very well suited for the study of complex mechanisms for heavy hydrocarbon combustion.

  3. Benefits of Outsourcing Strategy and IT Technology in Clinical Trials.

    PubMed

    Stamenovic, Milorad; Dobraca, Amra

    2017-09-01

    Aim of this paper is to describe some of models of outsourcing (numerous and response to different types of risks and increment of quality is based on individual problem and situation). Defining whether to outsource or not and whether to build or buy new information technology (IT) is question for contract research organization (CRO) and Pharma companies dealing with clinical trials, so the aim of this paper is to show business model that could make process of decision making less time consuming, less segmented and more efficient. This paper has a descriptive character, and represents a review of the literature that deals with the described issues. Outsourcing should enable optimal capacity flexibility (technology that is outsourced should be done only optimally not entirely). The goal with CRO partners is to establish equivalent levels of global quality, as extensions of other research and development activities (by unification of standards of performance of alliance partners with best standards of industry). IT is gaining greater significance at each stage of clinical study and represent an inevitable element of the quality of a clinical study (for the purpose of monitoring of clinical site activities, data collection and management, medical monitoring, statistical programming, statistical analysis, clinical study reporting). CROs are able to maximize work within the CRO global development, to support the notion of a fully integrated outsourced company; facilitate the use of similar business processes and norms, reusing established CRO standards and improve CRO operational decision making within outsourced studies by providing consistent and current information across outsourced and in-house activities.

  4. Benefits of Outsourcing Strategy and IT Technology in Clinical Trials

    PubMed Central

    Stamenovic, Milorad; Dobraca, Amra

    2017-01-01

    Introduction: Aim of this paper is to describe some of models of outsourcing (numerous and response to different types of risks and increment of quality is based on individual problem and situation). Defining whether to outsource or not and whether to build or buy new information technology (IT) is question for contract research organization (CRO) and Pharma companies dealing with clinical trials, so the aim of this paper is to show business model that could make process of decision making less time consuming, less segmented and more efficient. Material and methods: This paper has a descriptive character, and represents a review of the literature that deals with the described issues. Results: Outsourcing should enable optimal capacity flexibility (technology that is outsourced should be done only optimally not entirely). The goal with CRO partners is to establish equivalent levels of global quality, as extensions of other research and development activities (by unification of standards of performance of alliance partners with best standards of industry). IT is gaining greater significance at each stage of clinical study and represent an inevitable element of the quality of a clinical study (for the purpose of monitoring of clinical site activities, data collection and management, medical monitoring, statistical programming, statistical analysis, clinical study reporting). Conclusion: CROs are able to maximize work within the CRO global development, to support the notion of a fully integrated outsourced company; facilitate the use of similar business processes and norms, reusing established CRO standards and improve CRO operational decision making within outsourced studies by providing consistent and current information across outsourced and in-house activities. PMID:29114116

  5. BikeMaps.org: A Global Tool for Collision and Near Miss Mapping

    PubMed Central

    Nelson, Trisalyn A.; Denouden, Taylor; Jestico, Benjamin; Laberee, Karen; Winters, Meghan

    2015-01-01

    There are many public health benefits to cycling, such as chronic disease reduction and improved air quality. Real and perceived concerns about safety are primary barriers to new ridership. Due to limited forums for official reporting of cycling incidents, lack of comprehensive data is limiting our ability to study cycling safety and conduct surveillance. Our goal is to introduce BikeMaps.org, a new website developed by the authors for crowd-source mapping of cycling collisions and near misses. BikeMaps.org is a global mapping system that allows citizens to map locations of cycling incidents and report on the nature of the event. Attributes collected are designed for spatial modeling research on predictors of safety and risk, and to aid surveillance and planning. Released in October 2014, within 2 months the website had more than 14,000 visitors and mapping in 14 countries. Collisions represent 38% of reports (134/356) and near misses 62% (222/356). In our pilot city, Victoria, Canada, citizens mapped data equivalent to about 1 year of official cycling collision reports within 2 months via BikeMaps.org. Using report completeness as an indicator, early reports indicate that data are of high quality with 50% being fully attributed and another 10% having only one missing attribute. We are advancing this technology, with the development of a mobile App, improved data visualization, real-time altering of hazard reports, and automated open-source tools for data sharing. Researchers and citizens interested in utilizing the BikeMaps.org technology can get involved by encouraging citizen mapping in their region. PMID:25870852

  6. BikeMaps.org: A Global Tool for Collision and Near Miss Mapping.

    PubMed

    Nelson, Trisalyn A; Denouden, Taylor; Jestico, Benjamin; Laberee, Karen; Winters, Meghan

    2015-01-01

    There are many public health benefits to cycling, such as chronic disease reduction and improved air quality. Real and perceived concerns about safety are primary barriers to new ridership. Due to limited forums for official reporting of cycling incidents, lack of comprehensive data is limiting our ability to study cycling safety and conduct surveillance. Our goal is to introduce BikeMaps.org, a new website developed by the authors for crowd-source mapping of cycling collisions and near misses. BikeMaps.org is a global mapping system that allows citizens to map locations of cycling incidents and report on the nature of the event. Attributes collected are designed for spatial modeling research on predictors of safety and risk, and to aid surveillance and planning. Released in October 2014, within 2 months the website had more than 14,000 visitors and mapping in 14 countries. Collisions represent 38% of reports (134/356) and near misses 62% (222/356). In our pilot city, Victoria, Canada, citizens mapped data equivalent to about 1 year of official cycling collision reports within 2 months via BikeMaps.org. Using report completeness as an indicator, early reports indicate that data are of high quality with 50% being fully attributed and another 10% having only one missing attribute. We are advancing this technology, with the development of a mobile App, improved data visualization, real-time altering of hazard reports, and automated open-source tools for data sharing. Researchers and citizens interested in utilizing the BikeMaps.org technology can get involved by encouraging citizen mapping in their region.

  7. The Effects of Global Change upon United States Air Quality

    EPA Science Inventory

    To understand more fully the effects of global changes on ambient concentrations of ozone and particulate matter with aerodynamic diameter smaller than 2.5 μm (PM2.5) in the US, we conducted a comprehensive modeling effort to evaluate explicitly the effects of change...

  8. LOCAL AND GLOBAL DYNAMICS OF POLYLACTIDES. (R826733)

    EPA Science Inventory

    Polylactides (PLAs) are a family of degradable plastics having a component of the dipole moment both perpendicular and parallel to the polymer backbone (i.e. is a type-A polymer). We have studied the sub-glass, segmental and global chain dynamics in a series of fully amorphous...

  9. Impairment of willed actions and use of advance information for movement preparation in schizophrenia

    PubMed Central

    Fuller, R.; Jahanshahi, M.

    1999-01-01

    OBJECTIVES—To assess willed actions in patients with schizophrenia using reaction time (RT) tasks that differ in the degree to which they involve volitionally controlled versus stimulus driven responses.
METHODS—Ten patients diagnosed with schizophrenia and 13 normal controls of comparable age were tested. Subjects performed a visual simple RT (SRT), an uncued four choice reaction time (CRT), and a fully cued four choice RT task. A stimulus 1(S1)−stimulus 2(S2) paradigm was used. The warning signal/precue (S1) preceded the imperative stimulus (S2) by either 0 (no warning signal or precue) 200, 800, 1600, or 3200ms.
RESULTS—The patients with schizophrenia had significantly slower RTs and movement times than normal subjects across all RT tasks. The unwarned SRT trials were significantly faster than the uncued CRT trials for both groups. For both groups, fully cued CRTs were significantly faster than the uncued CRTs. However, the S1−S2 interval had a differential effect on CRTs in the two groups. For the normal subjects fully cued CRTs and SRTs were equivalent when S1-S2 intervals were 800 ms or longer. A similar pattern of effects was not seen in the patients with schizophrenia, for whom the fully cued CRT were unexpectedly equivalent to SRT for the 200 ms interval and expectedly for the 1600 ms S1-S2 interval, but not the 3200 or 800 ms intervals.
CONCLUSIONS—Patients with schizophrenia were able to use advance information inherent in SRT or provided by the precue in fully cued CRT to speed up RT relative to uncued CRT. However, in the latter task, in which the volitional demands of preprogramming are higher since a different response has to be prepared on each trial, patients showed some unusual and inconsistent interval effects suggesting instability of attentional set. It is possible that future studies using RT tasks with higher volitional demands in patients with predominance of negative signs may disclose greater deficits in willed action in schizophrenia.

 PMID:10201424

  10. The fully actuated traffic control problem solved by global optimization and complementarity

    NASA Astrophysics Data System (ADS)

    Ribeiro, Isabel M.; de Lurdes de Oliveira Simões, Maria

    2016-02-01

    Global optimization and complementarity are used to determine the signal timing for fully actuated traffic control, regarding effective green and red times on each cycle. The average values of these parameters can be used to estimate the control delay of vehicles. In this article, a two-phase queuing system for a signalized intersection is outlined, based on the principle of minimization of the total waiting time for the vehicles. The underlying model results in a linear program with linear complementarity constraints, solved by a sequential complementarity algorithm. Departure rates of vehicles during green and yellow periods were treated as deterministic, while arrival rates of vehicles were assumed to follow a Poisson distribution. Several traffic scenarios were created and solved. The numerical results reveal that it is possible to use global optimization and complementarity over a reasonable number of cycles and determine with efficiency effective green and red times for a signalized intersection.

  11. Attenuation-based size metric for estimating organ dose to patients undergoing tube current modulated CT exams

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Bostani, Maryam, E-mail: mbostani@mednet.ucla.edu; McMillan, Kyle; Lu, Peiyun

    2015-02-15

    Purpose: Task Group 204 introduced effective diameter (ED) as the patient size metric used to correlate size-specific-dose-estimates. However, this size metric fails to account for patient attenuation properties and has been suggested to be replaced by an attenuation-based size metric, water equivalent diameter (D{sub W}). The purpose of this study is to investigate different size metrics, effective diameter, and water equivalent diameter, in combination with regional descriptions of scanner output to establish the most appropriate size metric to be used as a predictor for organ dose in tube current modulated CT exams. Methods: 101 thoracic and 82 abdomen/pelvis scans frommore » clinically indicated CT exams were collected retrospectively from a multidetector row CT (Sensation 64, Siemens Healthcare) with Institutional Review Board approval to generate voxelized patient models. Fully irradiated organs (lung and breasts in thoracic scans and liver, kidneys, and spleen in abdominal scans) were segmented and used as tally regions in Monte Carlo simulations for reporting organ dose. Along with image data, raw projection data were collected to obtain tube current information for simulating tube current modulation scans using Monte Carlo methods. Additionally, previously described patient size metrics [ED, D{sub W}, and approximated water equivalent diameter (D{sub Wa})] were calculated for each patient and reported in three different ways: a single value averaged over the entire scan, a single value averaged over the region of interest, and a single value from a location in the middle of the scan volume. Organ doses were normalized by an appropriate mAs weighted CTDI{sub vol} to reflect regional variation of tube current. Linear regression analysis was used to evaluate the correlations between normalized organ doses and each size metric. Results: For the abdominal organs, the correlations between normalized organ dose and size metric were overall slightly higher for all three differently (global, regional, and middle slice) reported D{sub W} and D{sub Wa} than they were for ED, but the differences were not statistically significant. However, for lung dose, computed correlations using water equivalent diameter calculated in the middle of the image data (D{sub W,middle}) and averaged over the low attenuating region of lung (D{sub W,regional}) were statistically significantly higher than correlations of normalized lung dose with ED. Conclusions: To conclude, effective diameter and water equivalent diameter are very similar in abdominal regions; however, their difference becomes noticeable in lungs. Water equivalent diameter, specifically reported as a regional average and middle of scan volume, was shown to be better predictors of lung dose. Therefore, an attenuation-based size metric (water equivalent diameter) is recommended because it is more robust across different anatomic regions. Additionally, it was observed that the regional size metric reported as a single value averaged over a region of interest and the size metric calculated from a single slice/image chosen from the middle of the scan volume are highly correlated for these specific patient models and scan types.« less

  12. Electrothermal Equivalent Three-Dimensional Finite-Element Model of a Single Neuron.

    PubMed

    Cinelli, Ilaria; Destrade, Michel; Duffy, Maeve; McHugh, Peter

    2018-06-01

    We propose a novel approach for modelling the interdependence of electrical and mechanical phenomena in nervous cells, by using electrothermal equivalences in finite element (FE) analysis so that existing thermomechanical tools can be applied. First, the equivalence between electrical and thermal properties of the nerve materials is established, and results of a pure heat conduction analysis performed in Abaqus CAE Software 6.13-3 are validated with analytical solutions for a range of steady and transient conditions. This validation includes the definition of equivalent active membrane properties that enable prediction of the action potential. Then, as a step toward fully coupled models, electromechanical coupling is implemented through the definition of equivalent piezoelectric properties of the nerve membrane using the thermal expansion coefficient, enabling prediction of the mechanical response of the nerve to the action potential. Results of the coupled electromechanical model are validated with previously published experimental results of deformation for squid giant axon, crab nerve fibre, and garfish olfactory nerve fibre. A simplified coupled electromechanical modelling approach is established through an electrothermal equivalent FE model of a nervous cell for biomedical applications. One of the key findings is the mechanical characterization of the neural activity in a coupled electromechanical domain, which provides insights into the electromechanical behaviour of nervous cells, such as thinning of the membrane. This is a first step toward modelling three-dimensional electromechanical alteration induced by trauma at nerve bundle, tissue, and organ levels.

  13. Why were Matrix Mechanics and Wave Mechanics considered equivalent?

    NASA Astrophysics Data System (ADS)

    Perovic, Slobodan

    A recent rethinking of the early history of Quantum Mechanics deemed the late 1920s agreement on the equivalence of Matrix Mechanics and Wave Mechanics, prompted by Schrödinger's 1926 proof, a myth. Schrödinger supposedly failed to prove isomorphism, or even a weaker equivalence ("Schrödinger-equivalence") of the mathematical structures of the two theories; developments in the early 1930s, especially the work of mathematician von Neumann provided sound proof of mathematical equivalence. The alleged agreement about the Copenhagen Interpretation, predicated to a large extent on this equivalence, was deemed a myth as well. In response, I argue that Schrödinger's proof concerned primarily a domain-specific ontological equivalence, rather than the isomorphism or a weaker mathematical equivalence. It stemmed initially from the agreement of the eigenvalues of Wave Mechanics and energy-states of Bohr's Model that was discovered and published by Schrödinger in his first and second communications of 1926. Schrödinger demonstrated in this proof that the laws of motion arrived at by the method of Matrix Mechanics are satisfied by assigning the auxiliary role to eigenfunctions in the derivation of matrices (while he only outlined the reversed derivation of eigenfunctions from Matrix Mechanics, which was necessary for the proof of both isomorphism and Schrödinger-equivalence of the two theories). This result was intended to demonstrate the domain-specific ontological equivalence of Matrix Mechanics and Wave Mechanics, with respect to the domain of Bohr's atom. And although the mathematical equivalence of the theories did not seem out of the reach of existing theories and methods, Schrödinger never intended to fully explore such a possibility in his proof paper. In a further development of Quantum Mechanics, Bohr's complementarity and Copenhagen Interpretation captured a more substantial convergence of the subsequently revised (in light of the experimental results) Wave and Matrix Mechanics. I argue that both the equivalence and Copenhagen Interpretation can be deemed myths if one predicates the philosophical and historical analysis on a narrow model of physical theory which disregards its historical context, and focuses exclusively on its formal aspects and the exploration of the logical models supposedly implicit in it.

  14. Control topologies for deep space formation flying spacecraft

    NASA Technical Reports Server (NTRS)

    Hadaegh, F. Y.; Smith, R. S.

    2002-01-01

    This paper gives a characterization of the equivalent topologies and uses this approach to show that there exists a control topology which achieves a global tracking objective using only local controllers.

  15. Creating a global sub-daily precipitation dataset

    NASA Astrophysics Data System (ADS)

    Lewis, Elizabeth; Blenkinsop, Stephen; Fowler, Hayley

    2017-04-01

    Extremes of precipitation can cause flooding and droughts which can lead to substantial damages to infrastructure and ecosystems and can result in loss of life. It is still uncertain how hydrological extremes will change with global warming as we do not fully understand the processes that cause extreme precipitation under current climate variability. The INTENSE project is using a novel and fully-integrated data-modelling approach to provide a step-change in our understanding of the nature and drivers of global precipitation extremes and change on societally relevant timescales, leading to improved high-resolution climate model representation of extreme rainfall processes. The INTENSE project is in conjunction with the World Climate Research Programme (WCRP)'s Grand Challenge on 'Understanding and Predicting Weather and Climate Extremes' and the Global Water and Energy Exchanges Project (GEWEX) Science questions. The first step towards achieving this is to construct a new global sub-daily precipitation dataset. Data collection is ongoing and already covers North America, Europe, Asia and Australasia. Comprehensive, open source quality control software is being developed to set a new standard for verifying sub-daily precipitation data and a set of global hydroclimatic indices will be produced based upon stakeholder recommendations. This will provide a unique global data resource on sub-daily precipitation whose derived indices, e.g. monthly/annual maxima, will be freely available to the wider scientific community.

  16. Variational iteration method — a promising technique for constructing equivalent integral equations of fractional order

    NASA Astrophysics Data System (ADS)

    Wang, Yi-Hong; Wu, Guo-Cheng; Baleanu, Dumitru

    2013-10-01

    The variational iteration method is newly used to construct various integral equations of fractional order. Some iterative schemes are proposed which fully use the method and the predictor-corrector approach. The fractional Bagley-Torvik equation is then illustrated as an example of multi-order and the results show the efficiency of the variational iteration method's new role.

  17. The limits to equivalent living conditions: regional disparities in premature mortality in Germany.

    PubMed

    Plümper, Thomas; Laroze, Denise; Neumayer, Eric

    2018-01-01

    Despite the country's explicit political goal to establish equivalent living conditions across Germany, significant inequality continues to exist. We argue that premature mortality is an excellent proxy variable for testing the claim of equivalent living conditions since the root causes of premature death are socioeconomic. We analyse variation in premature mortality across Germany's 402 districts and cities in 2014. Premature mortality spatially clusters among geographically contiguous and proximate districts/cities and is higher in more urban places as well as in districts/cities located further north and in former East Germany. We demonstrate that, first, socioeconomic factors account for 62% of the cross-sectional variation in years of potential life lost and 70% of the variation in the premature mortality rate. Second, we show that these socioeconomic factors either entirely or almost fully eliminate the systematic spatial patterns that exist in premature mortality. On its own, fiscal redistribution, the centrepiece of how Germany aspires to establish its political goal, cannot generate equivalent living conditions in the absence of a comprehensive set of economic and social policies at all levels of political administration, tackling the disparities in socioeconomic factors that collectively result in highly unequal living conditions.

  18. Thickening the Global SOF Network

    DTIC Science & Technology

    2013-12-01

    in thought, and regulate both positive and negative emotions in oneself and others. EI is a necessary, but not fully sufficient, quality Green...assimilate emotions in thought, and regulate both positive and negative emotions in oneself and others. EI is a necessary, but not fully sufficient...both positive and negative emotions in oneself and others. B. THE HISTORY AND CONTROVERSY SURROUNDING EMOTIONAL INTELLIGENCE Since its first

  19. Male-typical courtship, spawning behavior, and olfactory sensitivity are induced to different extents by androgens in the goldfish suggesting they are controlled by different neuroendocrine mechanisms.

    PubMed

    Ghosal, Ratna; Sorensen, Peter W

    2016-06-01

    Male-typical reproductive behaviors vary greatly between different species of fishes with androgens playing a variety of roles that appear especially important in the gonochorist cypriniform fishes. The goldfish is an important model for the cypriniformes and while it is clear that male goldfish are fully feminized by prostaglandin F2α(PGF2α), it is not clear whether females will exhibit normal levels of male-typical reproductive behaviors as well as olfactory function when treated with androgens. To answer this question, we exposed sexually-regressed adult female goldfish to several types of androgen and monitored their tendencies to court (inspect females) and mate (spawn, or attempt to release gametes) while monitoring their olfactory sensitivity until changes in these attributes were maximized. Untreated adult males (intact) were included to determine the extent of masculinization. Treatments included the natural androgens, 11-ketotestosterone and testosterone (KT and T), administered via capsules (KT+T-implanted fish); the artificial androgen, methyltestosterone (MT), administered via capsules (MT-C); and MT administered in the fishes' water (MT-B). Male-typical olfactory sensitivity to a pheromone (15keto-PGF2α) increased in all androgen-treated groups and by week 6 was fully equivalent to that of males. Male-typical courtship behavior increased in all androgen-treated groups although slowly, and only MT-B females came to exhibit levels equivalent to those of males after 18weeks. In contrast, male-typical mating activity increased only slightly, with MT-B females reaching levels one-third that of males after 30weeks. We conclude that while androgens fully masculinize olfactory sensitivity and courtship behavior in goldfish, mating behavior is controlled by a different neuroendocrine mechanism(s) that has yet to be fully elucidated. Copyright © 2016 Elsevier Inc. All rights reserved.

  20. Lyapounov Functions of Closed Cone Fields: From Conley Theory to Time Functions

    NASA Astrophysics Data System (ADS)

    Bernard, Patrick; Suhr, Stefan

    2018-03-01

    We propose a theory "à la Conley" for cone fields using a notion of relaxed orbits based on cone enlargements, in the spirit of space time geometry. We work in the setting of closed (or equivalently semi-continuous) cone fields with singularities. This setting contains (for questions which are parametrization independent such as the existence of Lyapounov functions) the case of continuous vector-fields on manifolds, of differential inclusions, of Lorentzian metrics, and of continuous cone fields. We generalize to this setting the equivalence between stable causality and the existence of temporal functions. We also generalize the equivalence between global hyperbolicity and the existence of a steep temporal function.

  1. Does Global Progress on Sanitation Really Lag behind Water? An Analysis of Global Progress on Community- and Household-Level Access to Safe Water and Sanitation

    PubMed Central

    Cumming, Oliver; Elliott, Mark; Overbo, Alycia; Bartram, Jamie

    2014-01-01

    Safe drinking water and sanitation are important determinants of human health and wellbeing and have recently been declared human rights by the international community. Increased access to both were included in the Millennium Development Goals under a single dedicated target for 2015. This target was reached in 2010 for water but sanitation will fall short; however, there is an important difference in the benchmarks used for assessing global access. For drinking water the benchmark is community-level access whilst for sanitation it is household-level access, so a pit latrine shared between households does not count toward the Millennium Development Goal (MDG) target. We estimated global progress for water and sanitation under two scenarios: with equivalent household- and community-level benchmarks. Our results demonstrate that the “sanitation deficit” is apparent only when household-level sanitation access is contrasted with community-level water access. When equivalent benchmarks are used for water and sanitation, the global deficit is as great for water as it is for sanitation, and sanitation progress in the MDG-period (1990–2015) outstrips that in water. As both drinking water and sanitation access yield greater benefits at the household-level than at the community-level, we conclude that any post–2015 goals should consider a household-level benchmark for both. PMID:25502659

  2. Does global progress on sanitation really lag behind water? An analysis of global progress on community- and household-level access to safe water and sanitation.

    PubMed

    Cumming, Oliver; Elliott, Mark; Overbo, Alycia; Bartram, Jamie

    2014-01-01

    Safe drinking water and sanitation are important determinants of human health and wellbeing and have recently been declared human rights by the international community. Increased access to both were included in the Millennium Development Goals under a single dedicated target for 2015. This target was reached in 2010 for water but sanitation will fall short; however, there is an important difference in the benchmarks used for assessing global access. For drinking water the benchmark is community-level access whilst for sanitation it is household-level access, so a pit latrine shared between households does not count toward the Millennium Development Goal (MDG) target. We estimated global progress for water and sanitation under two scenarios: with equivalent household- and community-level benchmarks. Our results demonstrate that the "sanitation deficit" is apparent only when household-level sanitation access is contrasted with community-level water access. When equivalent benchmarks are used for water and sanitation, the global deficit is as great for water as it is for sanitation, and sanitation progress in the MDG-period (1990-2015) outstrips that in water. As both drinking water and sanitation access yield greater benefits at the household-level than at the community-level, we conclude that any post-2015 goals should consider a household-level benchmark for both.

  3. A fully traits-based approach to modeling global vegetation distribution.

    PubMed

    van Bodegom, Peter M; Douma, Jacob C; Verheijen, Lieneke M

    2014-09-23

    Dynamic Global Vegetation Models (DGVMs) are indispensable for our understanding of climate change impacts. The application of traits in DGVMs is increasingly refined. However, a comprehensive analysis of the direct impacts of trait variation on global vegetation distribution does not yet exist. Here, we present such analysis as proof of principle. We run regressions of trait observations for leaf mass per area, stem-specific density, and seed mass from a global database against multiple environmental drivers, making use of findings of global trait convergence. This analysis explained up to 52% of the global variation of traits. Global trait maps, generated by coupling the regression equations to gridded soil and climate maps, showed up to orders of magnitude variation in trait values. Subsequently, nine vegetation types were characterized by the trait combinations that they possess using Gaussian mixture density functions. The trait maps were input to these functions to determine global occurrence probabilities for each vegetation type. We prepared vegetation maps, assuming that the most probable (and thus, most suited) vegetation type at each location will be realized. This fully traits-based vegetation map predicted 42% of the observed vegetation distribution correctly. Our results indicate that a major proportion of the predictive ability of DGVMs with respect to vegetation distribution can be attained by three traits alone if traits like stem-specific density and seed mass are included. We envision that our traits-based approach, our observation-driven trait maps, and our vegetation maps may inspire a new generation of powerful traits-based DGVMs.

  4. Native temperature regime influences soil response to simulated warming

    Treesearch

    Timothy G. Whitby; Michael D. Madritch

    2013-01-01

    Anthropogenic climate change is expected to increase global temperatures and potentially increase soil carbon (C) mineralization, which could lead to a positive feedback between global warming and soil respiration. However the magnitude and spatial variability of belowground responses to warming are not yet fully understood. Some of the variability may depend...

  5. Assessing Global Perspectives at a Hispanic and Minority Serving Institution: A University-Wide Effort

    ERIC Educational Resources Information Center

    Durodoye, Beth A.; Coryell, Joellen E.; Redmon Wright, Robin; Pate, P. Elizabeth

    2011-01-01

    Across the United States, colleges and universities are increasingly giving voice to campus internationalization. However, the benefits of this endeavor cannot be fully realized if institutions do not balance their efforts with deliberate and consistent assessment practices. This study examined the global worldviews of students, faculty, and…

  6. Global CLEWs model - A novel application of OSeMOSYS

    NASA Astrophysics Data System (ADS)

    Avgerinopoulos, Georgios; Pereira Ramos, Eunice; Howells, Mark

    2017-04-01

    Over the past years, studies that analyse Nexus issues from a holistic point of view and not energy, land or water separately have been gaining momentum. This project aims at giving insights into global issues through the application and the analysis of a global scale OSeMOSYS model. The latter -which is based on a fully open and amendable code- has been used successfully in the latest years as it has been the producing fully accessible energy models suitable for capacity building and policy making suggestions. This study develops a CLEWs (climate, land, energy and water) model with the objective of interrogating global challenges (e.g. increasing food demand) and international trade features, with policy priorities on food security, resource efficiency, low-carbon energy and climate change mitigation, water availability and vulnerability to water stress and floods, water quality, biodiversity and ecosystem services. It will for instance assess (i) the impact of water constraints on food security and human development (clean water for human use; industrial and energy water demands), as well as (ii) the impact of climate change on aggravating or relieving water problems.

  7. Measles and Rubella Global Strategic Plan 2012-2020 midterm review.

    PubMed

    Orenstein, W A; Hinman, A; Nkowane, B; Olive, J M; Reingold, A

    2018-01-11

    1. Measles eradication is the ultimate goal but it is premature to set a date for its accomplishment. Existing regional elimination goals should be vigorously pursued to enable setting a global target by 2020. 2. The basic strategic approaches articulated in the Global Measles and Rubella Strategic Plan 2012-2020 are valid to achieve the goals but have not been fully implemented (or not appropriately adapted to local situations). 3. The report recommends a shift from primary reliance on supplementary immunization activities (SIAs) to assure two doses of measles-containing vaccine (MCV) are delivered to the target population to primary reliance on ongoing services to assure administration of two doses of MCV. Regular high quality SIAs will still be necessary while ongoing services are being strengthened. 4. The report recommends a shift from primary reliance on coverage to measure progress to incorporating disease incidence as a major indicator. 5. The report recommends that the measles/rubella vaccination program be considered an indicator for the quality of the overall immunization program and that measles/rubella incidence and measles and rubella vaccination coverage be considered as primary indicators of immunization program performance. 6. Polio transition presents both risks and opportunities: risks should be minimized and opportunities maximized. 7. A school entry immunization check could contribute significantly to strengthening overall immunization services with assurance that recommended doses of measles and rubella vaccines as well as other vaccines have been delivered and providing those vaccines at that time if the child is un- or under-vaccinated. 8. Program decisions should increasingly be based on good quality data and appropriate analysis. 9. The incorporation of rubella vaccination into the immunization program needs to be accelerated - it should be accorded equivalent emphasis as measles. 10. Outbreak investigation and response are critical but the most important thing is to prevent outbreaks. Copyright © 2017 World Health Organization. Published by Elsevier Ltd.. All rights reserved.

  8. Reconstruction of living bilayer human skin equivalent utilizing human fibrin as a scaffold.

    PubMed

    Mazlyzam, A L; Aminuddin, B S; Fuzina, N H; Norhayati, M M; Fauziah, O; Isa, M R; Saim, L; Ruszymah, B H I

    2007-05-01

    Our aim of this study was to develop a new methodology for constructing a bilayer human skin equivalent to create a more clinical compliance skin graft composite for the treatment of various skin defects. We utilized human plasma derived fibrin as the scaffold for the development of a living bilayer human skin equivalent: fibrin-fibroblast and fibrin-keratinocyte (B-FF/FK SE). Skin cells from six consented patients were culture-expanded to passage 1. For B-FF/FK SE formation, human fibroblasts were embedded in human fibrin matrix and subsequently another layer of human keratinocytes in human fibrin matrix was stacked on top. The B-FF/FK SE was then transplanted to athymic mice model for 4 weeks to evaluate its regeneration and clinical performance. The in vivo B-FF/FK SE has similar properties as native human skin by histological analysis and expression of basal Keratin 14 gene in the epidermal layer and Collagen type I gene in the dermal layer. Electron microscopy analysis of in vivo B-FF/FK SE showed well-formed and continuous epidermal-dermal junction. We have successfully developed a technique to engineer living bilayer human skin equivalent using human fibrin matrix. The utilization of culture-expanded human skin cells and fibrin matrix from human blood will allow a fully autologous human skin equivalent construction.

  9. Global bifurcation of solutions of the mean curvature spacelike equation in certain Friedmann-Lemaître-Robertson-Walker spacetimes

    NASA Astrophysics Data System (ADS)

    Dai, Guowei; Romero, Alfonso; Torres, Pedro J.

    2018-06-01

    We study the existence of spacelike graphs for the prescribed mean curvature equation in the Friedmann-Lemaître-Robertson-Walker (FLRW) spacetime. By using a conformal change of variable, this problem is translated into an equivalent problem in the Lorentz-Minkowski spacetime. Then, by using Rabinowitz's global bifurcation method, we obtain the existence and multiplicity of positive solutions for this equation with 0-Dirichlet boundary condition on a ball. Moreover, the global structure of the positive solution set is studied.

  10. From local to global measurements of nonclassical nonlinear elastic effects in geomaterials

    DOE PAGES

    Lott, Martin; Remillieux, Marcel C.; Le Bas, Pierre-Yves; ...

    2016-09-07

    Here, the equivalence between local and global measures of nonclassical nonlinear elasticity is established in a slender resonant bar. Nonlinear effects are first measured globally using nonlinear resonance ultrasound spectroscopy (NRUS), which monitors the relative shift of the resonance frequency as a function of the maximum dynamic strain in the sample. Subsequently, nonlinear effects are measured locally at various positions along the sample using dynamic acousto elasticity testing (DAET). Finally, after correcting analytically the DAET data for three-dimensional strain effects and integrating numerically these corrected data along the length of the sample, the NRUS global measures are retrieved almost exactly.

  11. Early life predictors of brain development at term-equivalent age in infants born across the gestational age spectrum.

    PubMed

    Thompson, Deanne K; Kelly, Claire E; Chen, Jian; Beare, Richard; Alexander, Bonnie; Seal, Marc L; Lee, Katherine; Matthews, Lillian G; Anderson, Peter J; Doyle, Lex W; Spittle, Alicia J; Cheong, Jeanie L Y

    2018-04-13

    It is well established that preterm infants have altered brain development compared with full-term (FT; ≥37 weeks' gestational age [GA]) infants, however the perinatal factors associated with brain development in preterm infants have not been fully elucidated. In particular, perinatal predictors of brain development may differ between very preterm infants (VP; <32 weeks' GA) and infants born moderate (MP; 32-33 weeks' GA) and late (LP; 34-36 weeks' GA) preterm, but this has not been studied. This study aimed to investigate the effects of early life predictors on brain volume and microstructure at term-equivalent age (TEA; 38-44 weeks), and whether these effects differ for GA groups (VP, MP, LP or FT). Structural images from 328 infants (91 VP, 63 MP, 104 LP and 70 FT) were segmented into white matter, cortical grey matter, cerebrospinal fluid, subcortical grey matter, brainstem and cerebellum. Cortical grey matter and white matter images were analysed using voxel-based morphometry. Fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD) and radial diffusivity (RD) images from 361 infants (92 VP, 69 MP, 120 LP and 80 FT) were analysed using Tract-Based Spatial Statistics. Relationships between early life predictors (birthweight standard deviation score [BWSDS], multiple birth, sex, postnatal growth and social risk) and global brain volumes were analysed using linear regressions. Relationships between early life predictors and regional brain volumes and diffusion measures were analysed using voxelwise non-parametric permutation testing. Male sex was associated with higher global volumes of all tissues and higher regional volumes throughout much of the cortical grey matter and white matter, particularly in the FT group. Male sex was also associated with lower FA and higher AD, RD and MD in the optic radiation, external and internal capsules and corona radiata, and these associations were generally similar between GA groups. Higher BWSDS was associated with higher global volumes of all tissues and higher regional volumes in much of the cortical grey matter and white matter in all GA groups, as well as higher FA and lower RD and MD in many major tracts (corpus callosum, optic radiation, internal and external capsules and corona radiata), particularly in the MP and LP groups. Multiple birth and social risk also showed associations with global and regional volumes and regional diffusion values which varied by GA group, but these associations were not independent of the other early life predictors. Postnatal growth was not associated with brain volumes or diffusion values. Early life predictors of brain volumes and microstructure at TEA include sex, BWSDS, multiple birth and social risk, which have different effects based on GA group at birth. This study improves knowledge of the perinatal factors associated with brain abnormalities in infants born across the prematurity spectrum. Copyright © 2018. Published by Elsevier Inc.

  12. Estudio comparativo de los metodos analitico-sintetico y global en el aprendizaje de la lectura (Comparative Study of the Analytical-Synthetical (Phonics) and Global (Sight) Reading Methods).

    ERIC Educational Resources Information Center

    Carbonell de Grompone, Maria A.; And Others

    An investigation into the phonics and sight methods of reading instruction being taught in Uruguay schools seeks valid predictions in support of each approach. The study, written in Spanish, examines the progressive reading habits and abilities of 12 first-grade classes. Teachers assigned to teach each method uniformly had equivalent training and…

  13. Defense Science Board Task Force on The Future of the Global Positioning System

    DTIC Science & Technology

    2005-10-01

    interference. Incorporate a fully reprogrammable Navigation Payload aboard GPS satellites as soon as practicable to enable future flexibility in signal...its use increases in automobiles , it is becoming a significant factor in E-911-type situations, where emergency vehicles are dispatched to accident...mitigation for GPS against both intentional and unintentional interference. Incorporate a fully reprogrammable Navigation Payload aboard GPS

  14. An approach for heterogeneous and loosely coupled geospatial data distributed computing

    NASA Astrophysics Data System (ADS)

    Chen, Bin; Huang, Fengru; Fang, Yu; Huang, Zhou; Lin, Hui

    2010-07-01

    Most GIS (Geographic Information System) applications tend to have heterogeneous and autonomous geospatial information resources, and the availability of these local resources is unpredictable and dynamic under a distributed computing environment. In order to make use of these local resources together to solve larger geospatial information processing problems that are related to an overall situation, in this paper, with the support of peer-to-peer computing technologies, we propose a geospatial data distributed computing mechanism that involves loosely coupled geospatial resource directories and a term named as Equivalent Distributed Program of global geospatial queries to solve geospatial distributed computing problems under heterogeneous GIS environments. First, a geospatial query process schema for distributed computing as well as a method for equivalent transformation from a global geospatial query to distributed local queries at SQL (Structured Query Language) level to solve the coordinating problem among heterogeneous resources are presented. Second, peer-to-peer technologies are used to maintain a loosely coupled network environment that consists of autonomous geospatial information resources, thus to achieve decentralized and consistent synchronization among global geospatial resource directories, and to carry out distributed transaction management of local queries. Finally, based on the developed prototype system, example applications of simple and complex geospatial data distributed queries are presented to illustrate the procedure of global geospatial information processing.

  15. Rapid Ultrasonic Inspection of Artillery Projectiles

    DTIC Science & Technology

    1980-11-01

    field behavior as a function of gap separation d 26 Fig. 14 Electromagnet equivalent circuit model use for final design of yoke, pole pieces and...card 64 Fig. 37 Frequency response of receiver circuit 66 Fig. 38 a) Configuration of EMAT used to launch both longitudinal and circumferential... circuit for OD and ID location 88 Fig. 51 Photograph of fully assembled EMAT inspection system during projectile inspection 92 Fig. 52 Sequence

  16. Flexible Manufacturing System Handbook. Volume IV. Appendices

    DTIC Science & Technology

    1983-02-01

    and Acceptance Test(s)" on page 26 of this Proposal Request. 1.1.10 Options 1. Centralized Automatic Chip/Coolant Recovery System a. Scope The...viable, from manual- ly moving the pallet/fixture/part combinations from machine to machine to fully automatic , unmanned material handling systems , such...English. Where dimensions are shown in metric units, the English system (inch) equivalent will also be shown. Hydraulic, pneumatic , and electrical

  17. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Ip, Hiu Yan; Schmidt, Fabian, E-mail: iphys@mpa-garching.mpg.de, E-mail: fabians@mpa-garching.mpg.de

    Density perturbations in cosmology, i.e. spherically symmetric adiabatic perturbations of a Friedmann-Lemaȋtre-Robertson-Walker (FLRW) spacetime, are locally exactly equivalent to a different FLRW solution, as long as their wavelength is much larger than the sound horizon of all fluid components. This fact is known as the 'separate universe' paradigm. However, no such relation is known for anisotropic adiabatic perturbations, which correspond to an FLRW spacetime with large-scale tidal fields. Here, we provide a closed, fully relativistic set of evolutionary equations for the nonlinear evolution of such modes, based on the conformal Fermi (CFC) frame. We show explicitly that the tidal effectsmore » are encoded by the Weyl tensor, and are hence entirely different from an anisotropic Bianchi I spacetime, where the anisotropy is sourced by the Ricci tensor. In order to close the system, certain higher derivative terms have to be dropped. We show that this approximation is equivalent to the local tidal approximation of Hui and Bertschinger [1]. We also show that this very simple set of equations matches the exact evolution of the density field at second order, but fails at third and higher order. This provides a useful, easy-to-use framework for computing the fully relativistic growth of structure at second order.« less

  18. Automatic segmentation method of pelvic floor levator hiatus in ultrasound using a self-normalizing neural network

    PubMed Central

    Dietz, Hans Peter; D’hooge, Jan; Barratt, Dean; Deprest, Jan

    2018-01-01

    Abstract. Segmentation of the levator hiatus in ultrasound allows the extraction of biometrics, which are of importance for pelvic floor disorder assessment. We present a fully automatic method using a convolutional neural network (CNN) to outline the levator hiatus in a two-dimensional image extracted from a three-dimensional ultrasound volume. In particular, our method uses a recently developed scaled exponential linear unit (SELU) as a nonlinear self-normalizing activation function, which for the first time has been applied in medical imaging with CNN. SELU has important advantages such as being parameter-free and mini-batch independent, which may help to overcome memory constraints during training. A dataset with 91 images from 35 patients during Valsalva, contraction, and rest, all labeled by three operators, is used for training and evaluation in a leave-one-patient-out cross validation. Results show a median Dice similarity coefficient of 0.90 with an interquartile range of 0.08, with equivalent performance to the three operators (with a Williams’ index of 1.03), and outperforming a U-Net architecture without the need for batch normalization. We conclude that the proposed fully automatic method achieved equivalent accuracy in segmenting the pelvic floor levator hiatus compared to a previous semiautomatic approach. PMID:29340289

  19. Automatic segmentation method of pelvic floor levator hiatus in ultrasound using a self-normalizing neural network.

    PubMed

    Bonmati, Ester; Hu, Yipeng; Sindhwani, Nikhil; Dietz, Hans Peter; D'hooge, Jan; Barratt, Dean; Deprest, Jan; Vercauteren, Tom

    2018-04-01

    Segmentation of the levator hiatus in ultrasound allows the extraction of biometrics, which are of importance for pelvic floor disorder assessment. We present a fully automatic method using a convolutional neural network (CNN) to outline the levator hiatus in a two-dimensional image extracted from a three-dimensional ultrasound volume. In particular, our method uses a recently developed scaled exponential linear unit (SELU) as a nonlinear self-normalizing activation function, which for the first time has been applied in medical imaging with CNN. SELU has important advantages such as being parameter-free and mini-batch independent, which may help to overcome memory constraints during training. A dataset with 91 images from 35 patients during Valsalva, contraction, and rest, all labeled by three operators, is used for training and evaluation in a leave-one-patient-out cross validation. Results show a median Dice similarity coefficient of 0.90 with an interquartile range of 0.08, with equivalent performance to the three operators (with a Williams' index of 1.03), and outperforming a U-Net architecture without the need for batch normalization. We conclude that the proposed fully automatic method achieved equivalent accuracy in segmenting the pelvic floor levator hiatus compared to a previous semiautomatic approach.

  20. Multilevel Optimization Framework for Hierarchical Stiffened Shells Accelerated by Adaptive Equivalent Strategy

    NASA Astrophysics Data System (ADS)

    Wang, Bo; Tian, Kuo; Zhao, Haixin; Hao, Peng; Zhu, Tianyu; Zhang, Ke; Ma, Yunlong

    2017-06-01

    In order to improve the post-buckling optimization efficiency of hierarchical stiffened shells, a multilevel optimization framework accelerated by adaptive equivalent strategy is presented in this paper. Firstly, the Numerical-based Smeared Stiffener Method (NSSM) for hierarchical stiffened shells is derived by means of the numerical implementation of asymptotic homogenization (NIAH) method. Based on the NSSM, a reasonable adaptive equivalent strategy for hierarchical stiffened shells is developed from the concept of hierarchy reduction. Its core idea is to self-adaptively decide which hierarchy of the structure should be equivalent according to the critical buckling mode rapidly predicted by NSSM. Compared with the detailed model, the high prediction accuracy and efficiency of the proposed model is highlighted. On the basis of this adaptive equivalent model, a multilevel optimization framework is then established by decomposing the complex entire optimization process into major-stiffener-level and minor-stiffener-level sub-optimizations, during which Fixed Point Iteration (FPI) is employed to accelerate convergence. Finally, the illustrative examples of the multilevel framework is carried out to demonstrate its efficiency and effectiveness to search for the global optimum result by contrast with the single-level optimization method. Remarkably, the high efficiency and flexibility of the adaptive equivalent strategy is indicated by compared with the single equivalent strategy.

  1. Cyclo-octafluorobutane (PFC-318) in the global atmosphere

    NASA Astrophysics Data System (ADS)

    Muhle, J.; Vollmer, M. K.; Fraser, P. J.; Rhee, T. S.; Ivy, D. J.; Arnold, T.; Harth, C. M.; Salameh, P.; O'Doherty, S.; Young, D.; Steele, P.; Krummel, P. B.; Leist, M.; Schmidbauer, N.; Lunder, C.; Kim, J.; Kim, K.; Reimann, S.; Simmonds, P.; Prinn, R. G.; Weiss, R. F.

    2010-12-01

    PFC-318 (c-C4F8, cyclo-octafluorobutane) is a long-lived (3200 years) perfluorocarbon (PFC) greenhouse gas with a high 100-year Global Warming Potential (GWP100 = 10,300) and a wide range of industrial uses. We extend previous atmospheric measurements of PFC-318 in the Cape Grim Air Archive (Oram, 1999) with our new in situ measurements from remote and urban AGAGE (Advanced Global Atmospheric Gases Experiment) and affiliated stations. Our longest in situ record is from the Jungfraujoch observatory in the Swiss Alps, and our data set is augmented by measurements of flasks from the King Sejong and Troll coastal Antarctic stations and several locations in the Northern Hemisphere. In mid-2009 we find ˜1.25 ppt (parts-per-trillion, dry mol fraction) in the Northern Hemisphere and ˜1.20 ppt in the Southern Hemisphere, with rise rates of ˜0.03 ppt/yr and an interhemispheric ratio of ˜1.04. We obtain PFC-318 emissions for 2008-2010 of ˜1 Gg/yr using a simple box model, and preliminary measurements of older archived air at SIO indicate similar emissions since at the least the late 1990s. In contrast, the EDGAR v4 emissions database estimates much lower PFC-318 emissions of 0.02 Gg/yr for 2005. Using GWP100 we calculate ˜10 million tons of CO2-equivalent PFC-318 emissions/yr for 2008-2010, about double the CO2-equivalent PFC-218 annual emissions, or 0.4 times the CO2-equivalent PFC-116 annual emissions, reported for 2008-2009 by Mühle et al. (2010). Thus PFC-318 is the third most important PFC in terms of CO2-equivalent emissions. We find mostly baseline conditions at remote AGAGE stations and urban sites in the USA, Europe, and Australia, in contrast to frequent above baseline conditions at Gosan station, Jeju Island, South Korea, indicating significant emission sources in East Asia as found by Saito et al. (2010). Oram, D.E., Trends of long-lived anthropogenic halocarbons in the Southern Hemisphere and model calculation of global emissions, Ph.D. thesis, University of East Anglia, Norwich, U.K., 1999. Mühle et al., Perfluorocarbons in the global atmosphere: tetrafluoromethane, hexafluoroethane, and octafluoropropane, Atmos. Chem. Phys., 10(11), 5145-5164, doi:10.5194/acp-10-5145-2010, 2010. Saito et al., Large Emissions of Perfluorocarbons in East Asia Deduced from Continuous Atmospheric Measurements, Environ. Sci. Technol., 44(11), 4089-4095, doi:10.1021/es1001488, 2010.

  2. Global Pressures, Local Reactions: Higher Education and Neo-Liberal Economic Policies

    ERIC Educational Resources Information Center

    Shumar, Wesley

    2004-01-01

    As a summary piece, this essay describes more fully the wider globalizing context in which both students and institutions of higher education are now located. It explores three transitions that signal this new configuration: the creation of new information and media technologies; the transformation of time and space; and the expansion of the…

  3. Schooling, Symbolism and Social Power: The Hijab in Republican France

    ERIC Educational Resources Information Center

    Windle, Joel

    2004-01-01

    To fully understand the implications of the global climate of heightened suspicion about Islam we must also be aware of its expression through distinctive national discourses. Media debate leading up to the adoption by the French parliament of a law banning the hijab at school fits into a global discourse, but also presents local strategies of…

  4. Life Cycle Assessment of Bio-diesel Production—A Comparative Analysis

    NASA Astrophysics Data System (ADS)

    Chatterjee, R.; Sharma, V.; Mukherjee, S.; Kumar, S.

    2014-04-01

    This work deals with the comparative analysis of environmental impacts of bio-diesel produced from Jatropha curcas, Rapeseed and Palm oil by applying the life cycle assessment and eco-efficiency concepts. The environmental impact indicators considered in the present paper include global warming potential (GWP, CO2 equivalent), acidification potential (AP, SO2 equivalent) and eutrophication potential (EP, NO3 equivalent). Different weighting techniques have been used to present and evaluate the environmental characteristics of bio-diesel. With the assistance of normalization values, the eco-efficiency was demonstrated in this work. The results indicate that the energy consumption of bio-diesel production is lowest in Jatropha while AP and EP are more in case of Jatropha than that of Rapeseed and Palm oil.

  5. Challenges in Preparing Veterinarians for Global Animal Health: Understanding the Public Sector.

    PubMed

    Hollier, Paul J; Quinn, Kaylee A; Brown, Corrie C

    Understanding of global systems is essential for veterinarians seeking to work in realms outside of their national domain. In the global system, emphasis remains on the public sector, and the current curricular emphasis in developed countries is on private clinical practice for the domestic employment market. There is a resulting lack of competency at graduation for effective engagement internationally. The World Organisation for Animal Health (OIE) has created standards for public sector operations in animal health, which must be functional to allow for sustainable development. This public sector, known as the Veterinary Services, or VS, serves to control public good diseases, and once effectively built and fully operational, allows for the evolution of a functional private sector, focused on private good diseases. Until the VS is fully functional, support of private good services is non-sustainable and any efforts delivered are not long lasting. As new graduates opt for careers working in the international development sector, it is essential that they understand the OIE guidelines to help support continuing improvement. Developing global veterinarians by inserting content into the veterinary curriculum on how public systems can operate effectively could markedly increase the potential of our professional contributions globally, and particularly in the areas most in need.

  6. Snapshots in X-ray binary evolution: Using Hα Emitters and post-starburst galaxies to study the age-dependence of XRB populations

    NASA Astrophysics Data System (ADS)

    Basu-Zych, Antara; Hornschemeier, Ann; Fragkos, Anastasios; Lehmer, Bret; Zezas, Andreas; Yukita, Mihoko; Tzanavaris, Panayiotis

    2018-01-01

    The X-ray emission in galaxies, due to X-ray binaries (XRBs), appears to depend on global galaxy properties such as stellar mass (M*), star formation rate (SFR), metallicity, and stellar age. This poster will present unique galaxy populations with well-defined stellar ages to test current relations and models. Specifically, Hα emitters (HAEs), which are nearby analogs of galaxies in the early universe, trace how XRBs form and evolve in young, metal-poor environments. We find that HAEs have lower X-ray luminosities per SFR and metallicity compared to other normal galaxies. At such young ages (<10Myr), XRBs may not have fully formed. Therefore, these observations provide constraints for the expected X-ray emission from XRBs in the early Universe. Post-starburst galaxies, selected by the strength of the Hδ equivalent width (> 500 Å), probe the XRB population related to stellar ages of 0.1-1 Gyr. At these ages, the donor star is expected to be an A-star whose mass is ~2 M⊙ and similar to that of the compact object, which may potentially lead to high mass transfer rates and high X-ray luminosities. Together, these samples offer important constraints for the evolution of XRBs with stellar age.

  7. Phytotoxicity, accumulation and transport of silver nanoparticles by Arabidopsis thaliana.

    PubMed

    Geisler-Lee, Jane; Wang, Qiang; Yao, Ying; Zhang, Wen; Geisler, Matt; Li, Kungang; Huang, Ying; Chen, Yongsheng; Kolmakov, Andrei; Ma, Xingmao

    2013-05-01

    The widespread availability of nano-enabled products in the global market may lead to the release of a substantial amount of engineered nanoparticles in the environment, which frequently display drastically different physiochemical properties than their bulk counterparts. The purpose of the study was to evaluate the impact of citrate-stabilised silver nanoparticles (AgNPs) on the plant Arabidopsis thaliana at three levels, physiological phytotoxicity, cellular accumulation and subcellular transport of AgNPs. The monodisperse AgNPs of three different sizes (20, 40 and 80 nm) aggregated into much larger sizes after mixing with quarter-strength Hoagland solution and became polydisperse. Immersion in AgNP suspension inhibited seedling root elongation and demonstrated a linear dose-response relationship within the tested concentration range. The phytotoxic effect of AgNPs could not be fully explained by the released silver ions. Plants exposed to AgNP suspensions bioaccumulated higher silver content than plants exposed to AgNO3 solutions (Ag(+) representative), indicating AgNP uptake by plants. AgNP toxicity was size and concentration dependent. AgNPs accumulated progressively in this sequence: border cells, root cap, columella and columella initials. AgNPs were apoplastically transported in the cell wall and found aggregated at plasmodesmata. In all the three levels studied, AgNP impacts differed from equivalent dosages of AgNO3.

  8. Fully Electrical Modeling of Thermoelectric Generators with Contact Thermal Resistance Under Different Operating Conditions

    NASA Astrophysics Data System (ADS)

    Siouane, Saima; Jovanović, Slaviša; Poure, Philippe

    2017-01-01

    The Seebeck effect is used in thermoelectric generators (TEGs) to supply electronic circuits by converting the waste thermal into electrical energy. This generated electrical power is directly proportional to the temperature difference between the TEG module's hot and cold sides. Depending on the applications, TEGs can be used either under constant temperature gradient between heat reservoirs or constant heat flow conditions. Moreover, the generated electrical power of a TEG depends not only on these operating conditions, but also on the contact thermal resistance. The influence of the contact thermal resistance on the generated electrical power have already been extensively reported in the literature. However, as reported in Park et al. (Energy Convers Manag 86:233, 2014) and Montecucco and Knox (IEEE Trans Power Electron 30:828, 2015), while designing TEG-powered circuit and systems, a TEG module is mostly modeled with a Thévenin equivalent circuit whose resistance is constant and voltage proportional to the temperature gradient applied to the TEG's terminals. This widely used simplified electrical TEG model is inaccurate and not suitable under constant heat flow conditions or when the contact thermal resistance is considered. Moreover, it does not provide realistic behaviour corresponding to the physical phenomena taking place in a TEG. Therefore, from the circuit designer's point of view, faithful and fully electrical TEG models under different operating conditions are needed. Such models are mainly necessary to design and evaluate the power conditioning electronic stages and the maximum power point tracking algorithms of a TEG power supply. In this study, these fully electrical models with the contact thermal resistance taken into account are presented and the analytical expressions of the Thévenin equivalent circuit parameters are provided.

  9. Design and performance of a SWaP short-range fully fibered monostatic laser rangefinder

    NASA Astrophysics Data System (ADS)

    Pallier, G.; Portalis, A.; Canat, G.; Chiquet, F.; Auffray, P.; Le, S.-D.; Le Flohic, M.

    2017-10-01

    The development of a multisensor optronic device requires Size, Weight and Power (SWaP), cost-effective and modular rangefinders while keeping a good range performance. We report on a fully fibered monostatic laser rangerfinder based on a one lens collimator used as the aperture of both the emission and reception channels. This has been possible thanks to the use of a diplexer. This design makes the system compacter and achieves a 200g system weight. In addition to its low volume, the fully fibered architecture allows designing a building block rangefinder with the collimator sub-system on one side and the laser and electronics cards module on the other side. Both are linked up by only an optical fiber. This kit format enables the rangefinder to better fit in any available space in higher level systems such as gimbals and multi-function imagers. Besides, no alignment is needed, and no parallax error is possible: the alignment between channels is guaranteed by design over the whole range. The emission/reception channels of the first prototype has a 28mm diameter 80mm focal length lens, and a 1.55μm 100μJ pulsed laser firing in a burst mode. The rangefinder is set in a class 1 configuration, and measures at 1Hz. The achieved Extinction Ratio is 30dB, which is equivalent to a range on NATO targets of 7km. The achieved ER being class 1M at 5Hz is even 32dB, which is equivalent to a range of 8.5km on NATO targets. More configurations are reported in this article with their associated performance.

  10. Cherenkov excited phosphorescence-based pO2 estimation during multi-beam radiation therapy: phantom and simulation studies

    NASA Astrophysics Data System (ADS)

    Holt, Robert W.; Zhang, Rongxiao; Esipova, Tatiana V.; Vinogradov, Sergei A.; Glaser, Adam K.; Gladstone, David J.; Pogue, Brian W.

    2014-09-01

    Megavoltage radiation beams used in External Beam Radiotherapy (EBRT) generate Cherenkov light emission in tissues and equivalent phantoms. This optical emission was utilized to excite an oxygen-sensitive phosphorescent probe, PtG4, which has been developed specifically for NIR lifetime-based sensing of the partial pressure of oxygen (pO2). Phosphorescence emission, at different time points with respect to the excitation pulse, was acquired by an intensifier-gated CCD camera synchronized with radiation pulses delivered by a medical linear accelerator. The pO2 distribution was tomographically recovered in a tissue-equivalent phantom during EBRT with multiple beams targeted from different angles at a tumor-like anomaly. The reconstructions were tested in two different phantoms that have fully oxygenated background, to compare a fully oxygenated and a fully deoxygenated inclusion. To simulate a realistic situation of EBRT, where the size and location of the tumor is well known, spatial information of a prescribed region was utilized in the recovery estimation. The phantom results show that region-averaged pO2 values were recovered successfully, differentiating aerated and deoxygenated inclusions. Finally, a simulation study was performed showing that pO2 in human brain tumors can be measured to within 15 mmHg for edge depths less than 10-20 mm using the Cherenkov Excited Phosphorescence Oxygen imaging (CEPhOx) method and PtG4 as a probe. This technique could allow non-invasive monitoring of pO2 in tumors during the normal process of EBRT, where beams are generally delivered from multiple angles or arcs during each treatment fraction.

  11. Cherenkov excited phosphorescence-based pO2 estimation during multi-beam radiation therapy: phantom and simulation studies.

    PubMed

    Holt, Robert W; Zhang, Rongxiao; Esipova, Tatiana V; Vinogradov, Sergei A; Glaser, Adam K; Gladstone, David J; Pogue, Brian W

    2014-09-21

    Megavoltage radiation beams used in External Beam Radiotherapy (EBRT) generate Cherenkov light emission in tissues and equivalent phantoms. This optical emission was utilized to excite an oxygen-sensitive phosphorescent probe, PtG4, which has been developed specifically for NIR lifetime-based sensing of the partial pressure of oxygen (pO2). Phosphorescence emission, at different time points with respect to the excitation pulse, was acquired by an intensifier-gated CCD camera synchronized with radiation pulses delivered by a medical linear accelerator. The pO2 distribution was tomographically recovered in a tissue-equivalent phantom during EBRT with multiple beams targeted from different angles at a tumor-like anomaly. The reconstructions were tested in two different phantoms that have fully oxygenated background, to compare a fully oxygenated and a fully deoxygenated inclusion. To simulate a realistic situation of EBRT, where the size and location of the tumor is well known, spatial information of a prescribed region was utilized in the recovery estimation. The phantom results show that region-averaged pO2 values were recovered successfully, differentiating aerated and deoxygenated inclusions. Finally, a simulation study was performed showing that pO2 in human brain tumors can be measured to within 15 mmHg for edge depths less than 10-20 mm using the Cherenkov Excited Phosphorescence Oxygen imaging (CEPhOx) method and PtG4 as a probe. This technique could allow non-invasive monitoring of pO2 in tumors during the normal process of EBRT, where beams are generally delivered from multiple angles or arcs during each treatment fraction.

  12. U.S. Space Policy and Space Industry Strangulation

    DTIC Science & Technology

    2010-03-01

    protecting U.S. national security, and creating an environment in which non-U.S. citizens can participate fully in the U.S. space industry. 14...still protecting U.S. national security, and creating an environment in which non-U.S. citizens can participate fully in the U.S. space industry...security, and creating and sustaining a globally competitive space industry. These realms are not mutually exclusive. If technologies are overly guarded

  13. NASA Global Hawk: A New Tool for Earth Science Research

    NASA Technical Reports Server (NTRS)

    Hall, Phill

    2009-01-01

    This slide presentation reviews the Global Hawk, a unmanned aerial vehicle (UAV) that NASA plans to use for Earth Sciences research. The Global Hawk is the world's first fully autonomous high-altitude, long-endurance aircraft, and is capable of conducting long duration missions. Plans are being made for the use of the aircraft on missions in the Arctic, Pacific and Western Atlantic Oceans. There are slides showing the Global Hawk Operations Center (GHOC), Flight Control and Air Traffic Control Communications Architecture, and Payload Integration and Accommodations on the Global Hawk. The first science campaign, planned for a study of the Pacific Ocean, is reviewed.

  14. Carbon dioxide emission implications if hydrofluorocarbons are regulated: a refrigeration case study.

    PubMed

    Blowers, Paul; Lownsbury, James M

    2010-03-01

    The U.S. is strongly considering regulating hydrofluorocarbons (HFCs) due to their global climate change forcing effects. A drop-in replacement hydrofluoroether has been evaluated using a gate-to-grave life cycle assessment of greenhouse gas emissions for the trade-offs between direct and indirect carbon dioxide equivalent emissions compared to a current HFC and a historically used refrigerant. The results indicate current regulations being considered may increase global climate change.

  15. Global stability and quadratic Hamiltonian structure in Lotka-Volterra and quasi-polynomial systems

    NASA Astrophysics Data System (ADS)

    Szederkényi, Gábor; Hangos, Katalin M.

    2004-04-01

    We show that the global stability of quasi-polynomial (QP) and Lotka-Volterra (LV) systems with the well-known logarithmic Lyapunov function is equivalent to the existence of a local generalized dissipative Hamiltonian description of the LV system with a diagonal quadratic form as a Hamiltonian function. The Hamiltonian function can be calculated and the quadratic dissipativity neighborhood of the origin can be estimated by solving linear matrix inequalities.

  16. Global Properties of Fully Convective Accretion Disks from Local Simulations

    NASA Astrophysics Data System (ADS)

    Bodo, G.; Cattaneo, F.; Mignone, A.; Ponzo, F.; Rossi, P.

    2015-08-01

    We present an approach to deriving global properties of accretion disks from the knowledge of local solutions derived from numerical simulations based on the shearing box approximation. The approach consists of a two-step procedure. First, a local solution valid for all values of the disk height is constructed by piecing together an interior solution obtained numerically with an analytical exterior radiative solution. The matching is obtained by assuming hydrostatic balance and radiative equilibrium. Although in principle the procedure can be carried out in general, it simplifies considerably when the interior solution is fully convective. In these cases, the construction is analogous to the derivation of the Hayashi tracks for protostars. The second step consists of piecing together the local solutions at different radii to obtain a global solution. Here we use the symmetry of the solutions with respect to the defining dimensionless numbers—in a way similar to the use of homology relations in stellar structure theory—to obtain the scaling properties of the various disk quantities with radius.

  17. On the global well-posedness theory for a class of PDE models for criminal activity

    NASA Astrophysics Data System (ADS)

    Rodríguez, N.

    2013-10-01

    We study a class of ‘reaction-advection-diffusion’ system of partial differential equations, which can be taken as basic models for criminal activity. This class of models are based on routine activity theory and other theories, such as the ‘repeat and near-repeat victimization effect’ and were first introduced in Short et al. (2008) [11]. In these models the criminal density is advected by a velocity field that depends on a scalar field, which measures the appeal to commit a crime. We refer to this scalar field as the attractiveness field. We prove local well-posedness of solutions for the general class of models. Furthermore, we prove global well-posedness of solutions to a fully-parabolic system with a velocity field that depends logarithmically on the attractiveness field. Our final result is the global well-posedness of solutions the fully-parabolic system with velocity field that depends linearly on the attractiveness field for small initial mass.

  18. Using fluorescent dyes as proxies to study herbicide removal by sorption in buffer zones.

    PubMed

    Dollinger, Jeanne; Dagès, Cécile; Voltz, Marc

    2017-04-01

    The performance of buffer zones for removing pesticides from runoff water varies greatly according to landscape settings, hydraulic regime, and system design. Evaluating the performance of buffers for a range of pesticides and environmental conditions can be very expensive. Recent studies suggested that the fluorescent dyes uranine and sulforhodamine B could be used as cost-effective surrogates of herbicides to evaluate buffer performance. However, while transformation mechanisms in buffers have been extensively documented, sorption processes of both dyes have rarely been investigated. In this study, we measured the adsorption, desorption, and kinetic sorption coefficients of uranine and sulforhodamine B for a diverse range of buffer zone materials (soils, litters, plants) and compared the adsorption coefficients (Kd) to those of selected herbicides. We also compared the global sorption capacity of 6 ditches, characterized by varying proportions of the aforementioned materials, between both dyes and a set of four herbicides using the sorption-induced pesticide retention indicator (SPRI). We found that both the individual Kd of uranine for the diverse buffer materials and the global sorption capacity of the ditches are equivalent to those of the herbicides diuron, isoproturon, and metolachlor. The Kd of sulforhodamine B on plants and soils are equivalent to those of glyphosate, and the global sorption capacities of the ditches are equivalent for both molecules. Hence, we demonstrate for the first time that uranine can be used as a proxy of moderately hydrophobic herbicides to evaluate the performance of buffer systems, whereas sulforhodamine B can serve as a proxy for more strongly sorbing herbicides.

  19. Agricultural Land Cover from Multitemporal C-Band SAR Data

    NASA Astrophysics Data System (ADS)

    Skriver, H.

    2013-12-01

    Henning Skriver DTU Space, Technical University of Denmark Ørsteds Plads, Building 348, DK-2800 Lyngby e-mail: hs@space.dtu.dk Problem description This paper focuses on land cover type from SAR data using high revisit acquisitions, including single and dual polarisation and fully polarimetric data, at C-band. The data set were acquired during an ESA-supported campaign, AgriSAR09, with the Radarsat-2 system. Ground surveys to obtain detailed land cover maps were performed during the campaign. Classification methods using single- and dual-polarisation data, and fully polarimetric data are used with multitemporal data with short revisit time. Results for airborne campaigns have previously been reported in Skriver et al. (2011) and Skriver (2012). In this paper, the short revisit satellite SAR data will be used to assess the trade-off between polarimetric SAR data and data as single or dual polarisation SAR data. This is particularly important in relation to the future GMES Sentinel-1 SAR satellites, where two satellites with a relatively wide swath will ensure a short revisit time globally. Questions dealt with are: which accuracy can we expect from a mission like the Sentinel-1, what is the improvement of using polarimetric SAR compared to single or dual polarisation SAR, and what is the optimum number of acquisitions needed. Methodology The data have sufficient number of looks for the Gaussian assumption to be valid for the backscatter coefficients for the individual polarizations. The classification method used for these data is therefore the standard Bayesian classification method for multivariate Gaussian statistics. For the full-polarimetric cases two classification methods have been applied, the standard ML Wishart classifier, and a method based on a reversible transform of the covariance matrix into backscatter intensities. The following pre-processing steps were performed on both data sets: The scattering matrix data in the form of SLC products were coregistered, converted to covariance matrix format and multilooked to a specific equivalent number of looks. Results The multitemporal data improve significantly the classification results, and single acquisition data cannot provide the necessary classification performance. The multitemporal data are especially important for the single and dual polarization data, but less important for the fully polarimetric data. The satellite data set produces realistic classification results based on about 2000 fields. The best classification results for the single-polarized mode provide classification errors in the mid-twenties. Using the dual-polarized mode reduces the classification error with about 5 percentage points, whereas the polarimetric mode reduces it with about 10 percentage points. These results show, that it will be possible to obtain reasonable results with relatively simple systems with short revisit time. This very important result shows that systems like the Sentinel-1 mission will be able to produce fairly good results for global land cover classification. References Skriver, H. et al., 2011, 'Crop Classification using Short-Revisit Multitemporal SAR Data', IEEE J. Sel. Topics in Appl. Earth Obs. Rem. Sens., vol. 4, pp. 423-431. Skriver, H., 2012, 'Crop classification by multitemporal C- and L-band single- and dual-polarization and fully polarimetric SAR', IEEE Trans. Geosc. Rem. Sens., vol. 50, pp. 2138-2149.

  20. Global Improvement in Genotyping of Human Papillomavirus DNA: the 2011 HPV LabNet International Proficiency Study

    PubMed Central

    Eklund, Carina; Forslund, Ola; Wallin, Keng-Ling

    2014-01-01

    Accurate and internationally comparable human papillomavirus (HPV) DNA genotyping is essential for HPV vaccine research and for HPV surveillance. The HPV Laboratory Network (LabNet) has designed international proficiency studies that can be issued regularly and in a reproducible manner. The 2011 HPV genotyping proficiency panel contained 43 coded samples composed of purified plasmids of 16 HPV types (HPV6, -11, -16, -18, -31, -33, -35, -39, -45, -51, -52, -56, -58, -59, -66, -68a, and -68b) and 3 extraction controls. Tests that detected 50 IU of HPV16 and HPV18 and 500 genome equivalents for the other 14 HPV types in both single and multiple infections were considered proficient. Ninety-six laboratories worldwide submitted 134 data sets. Twenty-five different HPV genotyping assay methods were used, including the Linear Array, line blot/INNO-LiPA, PapilloCheck, and PCR Luminex assays. The major oncogenic HPV types, HPV16 and HPV18, were proficiently detected in 97.0% (113/116) and 87.0% (103/118) of the data sets, respectively. In 2011, 51 data sets (39%) were 100% proficient for the detection of at least one HPV type, and 37 data sets (28%) were proficient for all 16 HPV types; this was an improvement over the panel results from the 2008 and 2010 studies, when <25 data sets (23% and 19% for 2008 and 2010, respectively) were fully proficient. The improvement was also evident for the 54 laboratories that had also participated in the previous proficiency studies. In conclusion, a continuing global proficiency program has documented worldwide improvement in the comparability and reliability of HPV genotyping assay performances. PMID:24478473

  1. Global invariants of paths and curves for the group of all linear similarities in the two-dimensional Euclidean space

    NASA Astrophysics Data System (ADS)

    Khadjiev, Djavvat; Ören, Idri˙s; Pekşen, Ömer

    Let E2 be the 2-dimensional Euclidean space, LSim(2) be the group of all linear similarities of E2 and LSim+(2) be the group of all orientation-preserving linear similarities of E2. The present paper is devoted to solutions of problems of global G-equivalence of paths and curves in E2 for the groups G = LSim(2),LSim+(2). Complete systems of global G-invariants of a path and a curve in E2 are obtained. Existence and uniqueness theorems are given. Evident forms of a path and a curve with the given global invariants are obtained.

  2. Solving fully fuzzy transportation problem using pentagonal fuzzy numbers

    NASA Astrophysics Data System (ADS)

    Maheswari, P. Uma; Ganesan, K.

    2018-04-01

    In this paper, we propose a simple approach for the solution of fuzzy transportation problem under fuzzy environment in which the transportation costs, supplies at sources and demands at destinations are represented by pentagonal fuzzy numbers. The fuzzy transportation problem is solved without converting to its equivalent crisp form using a robust ranking technique and a new fuzzy arithmetic on pentagonal fuzzy numbers. To illustrate the proposed approach a numerical example is provided.

  3. Development of Commercially Useable Codes to Simulate Aluminized Propellant Combustion and Related Issues

    DTIC Science & Technology

    2009-11-03

    functions and the second derivative of Green’s function. We exploit the geometrical characteristics of our integrand, i.e., we use spherical coordinates...statistically equivalent medium. Both the fully resolved probability spectrum and the geometrically exact particle shapes are considered in this...18 Buckmaster Research A1-18 FA9550-07-C-0123 References [1] B.D. Lubachevsky and F.H. Stillinger. “ Geometric properties of random disk packings”, J

  4. Proportional-scanning-phase method to suppress the vibrational noise in nonisotope dual-atom-interferometer-based weak-equivalence-principle-test experiments

    NASA Astrophysics Data System (ADS)

    Chen, Xi; Zhong, Jiaqi; Song, Hongwei; Zhu, Lei; Wang, Jin; Zhan, Mingsheng

    2014-08-01

    Vibrational noise is one of the most important noises that limits the performance of the nonisotopes atom-interferometers (AIs) -based weak-equivalence-principle (WEP) -test experiment. By analyzing the vibration-induced phases, we find that, although the induced phases are not completely common, their ratio is always a constant at every experimental data point, which is not fully utilized in the traditional elliptic curve-fitting method. From this point, we propose a strategy that can greatly suppress the vibration-induced phase noise by stabilizing the Raman laser frequencies at high precision and controlling the scanning-phase ratio. The noise rejection ratio can be as high as 1015 with arbitrary dual-species AIs. Our method provides a Lissajous curve, and the shape of the curve indicates the breakdown of the weak-equivalence-principle signal. Then we manage to derive an estimator for the differential phase of the Lissajous curve. This strategy could be helpful in extending the candidates of atomic species for high-precision AIs-based WEP-test experiments.

  5. Ziprasidone and amisulpride effectively treat negative symptoms of schizophrenia: results of a 12-week, double-blind study.

    PubMed

    Olié, Jean-Pierre; Spina, Edoardo; Murray, Stephen; Yang, Ruoyong

    2006-05-01

    We compared the efficacy of ziprasidone and amisulpride in the treatment of negative symptoms and overall psychopathology in subjects who had chronic schizophrenia with predominantly negative symptoms. This multicentre, 12-week, double-blind study randomly assigned subjects with predominantly negative-symptom schizophrenia [i.e. Positive and Negative Syndrome Scale (PANSS) Negative Subscale score >or=6 points greater than Positive Subscale score] to ziprasidone (40-80 mg b.i.d.; n=60) or amisulpride (50-100 mg b.i.d.; n=63). The primary efficacy variable was the change from baseline in PANSS Negative Subscale score. Secondary efficacy variables included change in scores for PANSS Total, Global Assessment of Functioning, Brief Psychiatric Rating Scale derived from PANSS Total and Core, Clinical Global Impression (CGI)-Severity and CGI-Improvement. For the change in PANSS Negative Subscale score, a ratio to assess the equivalence of the treatment groups was calculated from the least squares mean changes from baseline, with equivalence claimed if the lower limit of the 95% confidence interval of the ratio exceeded 0.60. Mean daily dose, adjusted for differential numbers of subjects and differential days between visits, was 118.0 mg for ziprasidone and 144.7 mg for amisulpride. Mean PANSS Negative Subscale scores improved over the 12-week treatment period for intent-to-treat subjects, evaluable subjects (subjects with >or=4 weeks of double-blind treatment and no protocol deviations) and completers in both treatment groups. Ziprasidone demonstrated efficacy comparable to amisulpride in improving negative symptoms and global psychopathology. The groups demonstrated comparable improvements in secondary efficacy variables. Both agents were generally well tolerated, with comparably low incidences of movement disorders. In subjects with negative symptom-prominent schizophrenia, ziprasidone in mean daily doses of 118 mg was equivalent to amisulpride in mean daily doses of 148 mg in ameliorating negative symptoms and comparable in improving overall psychopathology and global illness severity.

  6. Uncertainty propagation through an aeroelastic wind turbine model using polynomial surrogates

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Murcia, Juan Pablo; Réthoré, Pierre-Elouan; Dimitrov, Nikolay

    Polynomial surrogates are used to characterize the energy production and lifetime equivalent fatigue loads for different components of the DTU 10 MW reference wind turbine under realistic atmospheric conditions. The variability caused by different turbulent inflow fields are captured by creating independent surrogates for the mean and standard deviation of each output with respect to the inflow realizations. A global sensitivity analysis shows that the turbulent inflow realization has a bigger impact on the total distribution of equivalent fatigue loads than the shear coefficient or yaw miss-alignment. The methodology presented extends the deterministic power and thrust coefficient curves to uncertaintymore » models and adds new variables like damage equivalent fatigue loads in different components of the turbine. These surrogate models can then be implemented inside other work-flows such as: estimation of the uncertainty in annual energy production due to wind resource variability and/or robust wind power plant layout optimization. It can be concluded that it is possible to capture the global behavior of a modern wind turbine and its uncertainty under realistic inflow conditions using polynomial response surfaces. In conclusion, the surrogates are a way to obtain power and load estimation under site specific characteristics without sharing the proprietary aeroelastic design.« less

  7. Uncertainty propagation through an aeroelastic wind turbine model using polynomial surrogates

    DOE PAGES

    Murcia, Juan Pablo; Réthoré, Pierre-Elouan; Dimitrov, Nikolay; ...

    2017-07-17

    Polynomial surrogates are used to characterize the energy production and lifetime equivalent fatigue loads for different components of the DTU 10 MW reference wind turbine under realistic atmospheric conditions. The variability caused by different turbulent inflow fields are captured by creating independent surrogates for the mean and standard deviation of each output with respect to the inflow realizations. A global sensitivity analysis shows that the turbulent inflow realization has a bigger impact on the total distribution of equivalent fatigue loads than the shear coefficient or yaw miss-alignment. The methodology presented extends the deterministic power and thrust coefficient curves to uncertaintymore » models and adds new variables like damage equivalent fatigue loads in different components of the turbine. These surrogate models can then be implemented inside other work-flows such as: estimation of the uncertainty in annual energy production due to wind resource variability and/or robust wind power plant layout optimization. It can be concluded that it is possible to capture the global behavior of a modern wind turbine and its uncertainty under realistic inflow conditions using polynomial response surfaces. In conclusion, the surrogates are a way to obtain power and load estimation under site specific characteristics without sharing the proprietary aeroelastic design.« less

  8. Condensation-nuclei (Aitken Particle) measurement system used in NASA global atmospheric sampling program

    NASA Technical Reports Server (NTRS)

    Nyland, T. W.

    1979-01-01

    The condensation-nuclei (Aitken particle) measuring system used in the NASA Global Atmospheric Sampling Program is described. Included in the paper is a description of the condensation-nuclei monitor sensor, the pressurization system, and the Pollack-counter calibration system used to support the CN measurement. The monitor has a measurement range to 1000 CN/cm cubed and a noise level equivalent to 5 CN/cm cubed at flight altitudes between 6 and 13 km.

  9. 78 FR 47531 - Airworthiness Directives; Various Restricted Category Helicopters

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-06

    ... Technology, Inc.; Hagglund Helicopters, LLC (previously Western International Aviation, Inc.); International.... This AD requires creating a component history card or equivalent record for each main rotor grip (grip....); California Department of Forestry; Garlick Helicopters, Inc.; Global Helicopter Technology, Inc.; Hagglund...

  10. Hydrofluorocarbon (HFC) Emissions in China: An Inventory for 2005-2013 and Projections to 2050.

    PubMed

    Fang, Xuekun; Velders, Guus J M; Ravishankara, A R; Molina, Mario J; Hu, Jianxin; Prinn, Ronald G

    2016-02-16

    Many hydrofluorocarbons (HFCs) that are widely used as substitutes for ozone-depleting substances (now regulated under the Montreal Protocol) are very potent greenhouse gases (GHGs). China's past and future HFC emissions are of great interest because China has emerged as a major producer and consumer of HFCs. Here, we present for the first time a comprehensive inventory estimate of China's HFC emissions during 2005-2013. Results show a rapid increase in HFC production, consumption, and emissions in China during the period and that the emissions of HFC with a relatively high global warming potential (GWP) grew faster than those with a relatively low GWP. The proportions of China's historical HFC CO2-equivalent emissions to China's CO2 emissions or global HFC CO2-equivalent emissions increased rapidly during 2005-2013. Using the "business-as-usual" (BAU) scenario, in which HFCs are used to replace a significant fraction of hydrochlorofluorocarbons (HCFCs) in China (to date, there are no regulations on HFC uses in China), emissions of HFCs are projected to be significant components of China's and global future GHG emissions. However, potentials do exist for minimizing China's HFC emissions (for example, if regulations on HFC uses are established in China). Our findings on China's historical and projected HFC emission trajectories could also apply to other developing countries, with important implications for mitigating global GHG emissions.

  11. Exhaustive oxidation of a nickel dithiolate complex: some mechanistic insights en route to sulfate formation.

    PubMed

    Hosler, Erik R; Herbst, Robert W; Maroney, Michael J; Chohan, Balwant S

    2012-01-21

    A study of the step-wise oxidation of a Ni(II) diaminodithiolate complex through the formation of sulfate, the ultimate sulfur oxygenate, is reported. Controlled oxygenations or peroxidations of a neutral, planar, tetracoordinate, low-spin Ni(II) complex of a N(2)S(2)-donor ligand, (N,N'-dimethyl-N-N'-bis(2-mecaptoethyl)-1,3-propanediaminato) nickel(ii) (1), led to a series of sulfur oxygenates that have been isolated and characterized by ESI-MS and single-crystal X-ray diffraction. A monosulfenate complex (2) was detected by ESI-MS as a product of oxidation with one equivalent of H(2)O(2). However, this complex proved too unstable to isolate. Reaction of the dithiolate (1) with two equivalents of H(2)O(2) or one O(2) molecule leads to the formation of a monosulfinate complex (3), which was isolated and fully characterized by crystallography. The oxidation product of the monosulfinate (3) produced with either O(2) or H(2)O(2) is an interesting dimeric complex containing both sulfonate and thiolate ligands (4), this complex was fully characterized by crystallography, details of which were reported earlier by us. A disulfonate complex (7) is produced by reaction of 1 in the presence of O(2) or by reaction with exactly six equivalents of H(2)O(2). This complex was isolated and also fully characterized by crystallography. Possible intermediates in the conversion of the monosulfinate complex (3) to the disulfonate complex (7) include complexes with mixed sulfonate/sulfenate (5) or sulfonate/sulfinate (6) ligands. Complex 5, a four-oxygen adduct of 1, was not detected, but the sulfonate/sulfinate complex (6) was isolated and characterized. The oxidation chemistry of 1 is very different from that reported for other planar cis-N(2)S(2) Ni(ii) complexes including N,N'-dimethyl-N-N'-bis(2-mecaptoethyl)-1,3-ethylenediaminato) nickel(II), (8), and N,N'-bis(mercaptoethyl)-1,5-diazacyclooctane nickel(II). To address the structural aspects of the reactivity differences, the crystal structure of 8 was also determined. A comparison of the structures of planar Ni(II) complexes containing cis-dithiolate ligands, strongly suggests that the differences in reactivity are determined in part by the degree of flexibility that is allowed by the NN' chelate ring.

  12. Asymptotic Equivalence of Probability Measures and Stochastic Processes

    NASA Astrophysics Data System (ADS)

    Touchette, Hugo

    2018-03-01

    Let P_n and Q_n be two probability measures representing two different probabilistic models of some system (e.g., an n-particle equilibrium system, a set of random graphs with n vertices, or a stochastic process evolving over a time n) and let M_n be a random variable representing a "macrostate" or "global observable" of that system. We provide sufficient conditions, based on the Radon-Nikodym derivative of P_n and Q_n, for the set of typical values of M_n obtained relative to P_n to be the same as the set of typical values obtained relative to Q_n in the limit n→ ∞. This extends to general probability measures and stochastic processes the well-known thermodynamic-limit equivalence of the microcanonical and canonical ensembles, related mathematically to the asymptotic equivalence of conditional and exponentially-tilted measures. In this more general sense, two probability measures that are asymptotically equivalent predict the same typical or macroscopic properties of the system they are meant to model.

  13. Calculation of transient potential rise on the wind turbine struck by lightning.

    PubMed

    Xiaoqing, Zhang

    2014-01-01

    A circuit model is proposed in this paper for calculating the transient potential rise on the wind turbine struck by lightning. The model integrates the blade, sliding contact site, and tower and grounding system of the wind turbine into an equivalent circuit. The lightning current path from the attachment point to the ground can be fully described by the equivalent circuit. The transient potential responses are obtained in the different positions on the wind turbine by solving the circuit equations. In order to check the validity of the model, the laboratory measurement is made with a reduced-scale wind turbine. The measured potential waveform is compared with the calculated one and a better agreement is shown between them. The practical applicability of the model is also examined by a numerical example of a 2 MW Chinese-built wind turbine.

  14. Challenging, Eye-Opening, and Changing U.S. Teacher Training in Korea: Creating Experiences That Will Enhance Global Perspectives

    ERIC Educational Resources Information Center

    Oh, Kevin; Nussli, Natalie

    2014-01-01

    This case study explored the short-term international experience of pre-service teachers to create and enhance global perspectives. These teachers (n = 5), all female graduate students at a university in the U.S., were fully immersed in a foreign culture for three weeks while teaching English to primary and secondary students in Korea. Pre-,…

  15. Assessments in the Global Peace Operations Initiative: A Systems Engineering Approach

    DTIC Science & Technology

    2014-06-01

    police unit GCC GPOI Coordination Committee GIG GPOI Implementation Guide GPOI Global Peace Operations Initiative GRC GPOI Regional Committee G8...degree necessary to build a coherent assessments framework. The GPOI Implementation Guide ( GIG ) begins by alluding to what the program intended to...elements and associated interactions fully observed and understood. Using the U.S. economy as an example, Driscoll (2011) illustrates the common

  16. Local effects of partly cloudy skies on solar and emitted radiations

    NASA Technical Reports Server (NTRS)

    Whitney, D. A.; Venable, D. D.

    1981-01-01

    Solar radiation measurements are made on a routine basis. Global solar, atmospheric emitted, downwelled diffuse solar, and direct solar radiation measurement systems are fully operational with the first two in continuous operation. Fractional cloud cover measurements are made from GOES imagery or from ground based whole sky photographs. Normalized global solar irradiance values for partly cloudy skies were correlated to fractional cloud cover.

  17. Macroscopic constitutive equations of thermo-poroviscoelasticity derived using eigenstrains

    NASA Astrophysics Data System (ADS)

    Suvorov, A. P.; Selvadurai, A. P. S.

    2010-10-01

    Macroscopic constitutive equations for thermo-viscoelastic processes in a fully saturated porous medium are re-derived from basic principles of micromechanics applicable to solid multi-phase materials such as composites. Simple derivations of the constitutive relations and the void occupancy relationship are presented. The derivations use the notion of eigenstrain or, equivalently, eigenstress applied to the separate phases of a porous medium. Governing coupled equations for the displacement components and the fluid pressure are also obtained.

  18. Standardized 3D Bioprinting of Soft Tissue Models with Human Primary Cells.

    PubMed

    Rimann, Markus; Bono, Epifania; Annaheim, Helene; Bleisch, Matthias; Graf-Hausner, Ursula

    2016-08-01

    Cells grown in 3D are more physiologically relevant than cells cultured in 2D. To use 3D models in substance testing and regenerative medicine, reproducibility and standardization are important. Bioprinting offers not only automated standardizable processes but also the production of complex tissue-like structures in an additive manner. We developed an all-in-one bioprinting solution to produce soft tissue models. The holistic approach included (1) a bioprinter in a sterile environment, (2) a light-induced bioink polymerization unit, (3) a user-friendly software, (4) the capability to print in standard labware for high-throughput screening, (5) cell-compatible inkjet-based printheads, (6) a cell-compatible ready-to-use BioInk, and (7) standard operating procedures. In a proof-of-concept study, skin as a reference soft tissue model was printed. To produce dermal equivalents, primary human dermal fibroblasts were printed in alternating layers with BioInk and cultured for up to 7 weeks. During long-term cultures, the models were remodeled and fully populated with viable and spreaded fibroblasts. Primary human dermal keratinocytes were seeded on top of dermal equivalents, and epidermis-like structures were formed as verified with hematoxylin and eosin staining and immunostaining. However, a fully stratified epidermis was not achieved. Nevertheless, this is one of the first reports of an integrative bioprinting strategy for industrial routine application. © 2015 Society for Laboratory Automation and Screening.

  19. Population risk perceptions of global warming in Australia.

    PubMed

    Agho, Kingsley; Stevens, Garry; Taylor, Mel; Barr, Margo; Raphael, Beverley

    2010-11-01

    According to the World Health Organisation (WHO), global warming has the potential to dramatically disrupt some of life's essential requirements for health, water, air and food. Understanding how Australians perceive the risk of global warming is essential for climate change policy and planning. The aim of this study was to determine the prevalence of, and socio-demographic factors associated with, high levels of perceived likelihood that global warming would worsen, concern for self and family and reported behaviour changes. A module of questions on global warming was incorporated into the New South Wales Population Health Survey in the second quarter of 2007. This Computer Assisted Telephone Interview (CATI) was completed by a representative sample of 2004 adults. The weighted sample was comparable to the Australian population. Bivariate and multivariate statistical analyses were conducted to examine the socio-demographic and general health factors. Overall 62.1% perceived that global warming was likely to worsen; 56.3% were very or extremely concerned that they or their family would be directly affected by global warming; and 77.6% stated that they had made some level of change to the way they lived their lives, because of the possibility of global warming. After controlling for confounding factors, multivariate analyses revealed that those with high levels of psychological distress were 2.17 (Adjusted Odds Ratio (AOR)=2.17; CI: 1.16-4.03; P=0.015) times more likely to be concerned about global warming than those with low psychological distress levels. Those with a University degree or equivalent and those who lived in urban areas were significantly more likely to think that global warming would worsen compared to those without a University degree or equivalent and those who lived in the rural areas. Females were significantly (AOR=1.69; CI: 1.23-2.33; P=0.001) more likely to report they had made changes to the way they lived their lives due to the risk of global warming. A high proportion of respondents reported that they perceived that global warming would worsen, were concerned that it would affect them and their families and had already made changes in their lives because of it. These findings support a readiness in the population to deal with global warming. Future research and programs are needed to investigate population-level strategies for future action. Crown Copyright © 2010. Published by Elsevier Inc. All rights reserved.

  20. Nitrogen trifluoride global emissions estimated from updated atmospheric measurements

    PubMed Central

    Arnold, Tim; Harth, Christina M.; Mühle, Jens; Manning, Alistair J.; Salameh, Peter K.; Kim, Jooil; Ivy, Diane J.; Steele, L. Paul; Petrenko, Vasilii V.; Severinghaus, Jeffrey P.; Baggenstos, Daniel; Weiss, Ray F.

    2013-01-01

    Nitrogen trifluoride (NF3) has potential to make a growing contribution to the Earth’s radiative budget; however, our understanding of its atmospheric burden and emission rates has been limited. Based on a revision of our previous calibration and using an expanded set of atmospheric measurements together with an atmospheric model and inverse method, we estimate that the global emissions of NF3 in 2011 were 1.18 ± 0.21 Gg⋅y−1, or ∼20 Tg CO2-eq⋅y−1 (carbon dioxide equivalent emissions based on a 100-y global warming potential of 16,600 for NF3). The 2011 global mean tropospheric dry air mole fraction was 0.86 ± 0.04 parts per trillion, resulting from an average emissions growth rate of 0.09 Gg⋅y−2 over the prior decade. In terms of CO2 equivalents, current NF3 emissions represent between 17% and 36% of the emissions of other long-lived fluorinated compounds from electronics manufacture. We also estimate that the emissions benefit of using NF3 over hexafluoroethane (C2F6) in electronics manufacture is significant—emissions of between 53 and 220 Tg CO2-eq⋅y−1 were avoided during 2011. Despite these savings, total NF3 emissions, currently ∼10% of production, are still significantly larger than expected assuming global implementation of ideal industrial practices. As such, there is a continuing need for improvements in NF3 emissions reduction strategies to keep pace with its increasing use and to slow its rising contribution to anthropogenic climate forcing. PMID:23341630

  1. Fully decoupled monolithic projection method for natural convection problems

    NASA Astrophysics Data System (ADS)

    Pan, Xiaomin; Kim, Kyoungyoun; Lee, Changhoon; Choi, Jung-Il

    2017-04-01

    To solve time-dependent natural convection problems, we propose a fully decoupled monolithic projection method. The proposed method applies the Crank-Nicolson scheme in time and the second-order central finite difference in space. To obtain a non-iterative monolithic method from the fully discretized nonlinear system, we first adopt linearizations of the nonlinear convection terms and the general buoyancy term with incurring second-order errors in time. Approximate block lower-upper decompositions, along with an approximate factorization technique, are additionally employed to a global linearly coupled system, which leads to several decoupled subsystems, i.e., a fully decoupled monolithic procedure. We establish global error estimates to verify the second-order temporal accuracy of the proposed method for velocity, pressure, and temperature in terms of a discrete l2-norm. Moreover, according to the energy evolution, the proposed method is proved to be stable if the time step is less than or equal to a constant. In addition, we provide numerical simulations of two-dimensional Rayleigh-Bénard convection and periodic forced flow. The results demonstrate that the proposed method significantly mitigates the time step limitation, reduces the computational cost because only one Poisson equation is required to be solved, and preserves the second-order temporal accuracy for velocity, pressure, and temperature. Finally, the proposed method reasonably predicts a three-dimensional Rayleigh-Bénard convection for different Rayleigh numbers.

  2. Using a Morphine Equivalence Metric to Quantify Opioid Consumption: Examining the Capacity to Provide Effective Treatment of Debilitating Pain at the Global, Regional, and Country Levels

    PubMed Central

    Gilson, Aaron M.; Maurer, Martha A.; Ryan, Karen M.; Cleary, James F.; Rathouz, Paul J.

    2014-01-01

    Context Morphine has been considered the gold standard for treating moderate to severe pain, although many new opioid products and formulations have been marketed in the last two decades and should be considered when examining opioid consumption. Understanding opioid consumption is improved by using an equianalgesic measure that controls for the strengths of all examined opioids. Objectives The research objective was to utilize a morphine equivalence metric to determine the extent that morphine consumption relates to the total consumption of all other study opioids. Methods A Morphine Equivalence (ME) metric was created for morphine and for the aggregate consumption of each study opioid (Total ME), adjusted for country population to allow for uniform equianalgesic comparisons. Graphical and statistical evaluations of morphine use and Total ME consumption trends (between 1980 and 2009) were made for the global and geographic regional levels, and for selected developed and developing countries. Results Global morphine consumption rose dramatically in the early 1980s but has been significantly outpaced by Total ME since 1996. As expected, the extent of morphine and Total ME consumption varied notably among regions, with the Americas, Europe, and Oceania regions accounting for the highest morphine use and Total ME in 2009. Developing and least developed countries, compared to developed countries, demonstrated lower overall Total ME consumption. Conclusion Generally, worldwide morphine use has not increased at the rate of Total ME, especially in recent years. Examining a country's ability to effectively manage moderate to severe pain should extend beyond morphine to account for all available potent opioids. PMID:23017614

  3. On a numerical solving of random generated hexamatrix games

    NASA Astrophysics Data System (ADS)

    Orlov, Andrei; Strekalovskiy, Alexander

    2016-10-01

    In this paper, we develop a global search method for finding a Nash equilibrium in a hexamatrix game (polymatrix game of three players). The method, on the one hand, is based on the equivalence theorem of the problem of finding a Nash equilibrium in the game and a special mathematical optimization problem, and, on the other hand, on the usage of Global Search Theory for solving the latter problem. The efficiency of this approach is demonstrated by the results of computational testing.

  4. Mars: Crustal pore volume, cryospheric depth, and the global occurrence of groundwater

    NASA Technical Reports Server (NTRS)

    Clifford, Stephen M.

    1987-01-01

    It is argued that most of the Martian hydrosphere resides in a porous outer layer of crust that, based on a lunar analogy, appears to extend to a depth of about 10 km. The total pore volume of this layer is sufficient to store the equivalent of a global ocean of water some 500 to 1500 m deep. Thermal modeling suggests that about 300 to 500 m of water could be stored as ice within the crust. Any excess must exist as groundwater.

  5. Recycling of wood for particle board production: accounting of greenhouse gases and global warming contributions.

    PubMed

    Merrild, Hanna; Christensen, Thomas H

    2009-11-01

    The greenhouse gas (GHG) emissions related to the recycling of wood waste have been assessed with the purpose to provide useful data that can be used in accounting of greenhouse gas emissions. Here we present data related to the activities in a material recovery facility (MRF) where wood waste is shredded and foreign objects are removed in order to produce wood chips for use in the production of particleboard. The data are presented in accordance with the UOD (upstream, operational, downstream) framework presented in Gentil et al. (Waste Management & Research, 27, 2009). The GHG accounting shows that the emissions related to upstream activities (5 to 41 kg CO(2)-equivalents tonne( -1) wood waste) and to activities at the MRF (approximately 5 kg CO(2)-equivalents tonne(-1) wood waste) are negligible compared to the downstream processing (-560 to -120 kg CO(2)equivalents tonne(-1) wood waste). The magnitude of the savings in GHG emissions downstream are mainly related to savings in energy consumption for drying of fresh wood for particleboard production. However, the GHG account highly depends on the choices made in the modelling of the downstream system. The inclusion of saved electricity from avoided chipping of virgin wood does not change the results radically (-665 to -125 kg CO(2)-equivalents tonne(- 1) wood waste). However, if in addition it is assumed that the GHG emissions from combustion of wood has no global warming potential (GWP) and that the energy produced from excess wood due to recycling substitutes energy from fossil fuels, here assumed to be coal, potentially large downstream GHG emissions savings can be achieved by recycling of waste wood (-1.9 to -1.3 tonnes CO(2)-equivalents tonne(- 1) wood waste). As the data ranges are broad, it is necessary to carefully evaluate the feasibility of the data in the specific system which the GHG accounting is to be applied to.

  6. Impact on Bacterial Resistance of Therapeutically Nonequivalent Generics: The Case of Piperacillin-Tazobactam

    PubMed Central

    Rodriguez, Carlos A.; Agudelo, Maria; Aguilar, Yudy A.; Zuluaga, Andres F.

    2016-01-01

    Previous studies have demonstrated that pharmaceutical equivalence and pharmacokinetic equivalence of generic antibiotics are necessary but not sufficient conditions to guarantee therapeutic equivalence (better called pharmacodynamic equivalence). In addition, there is scientific evidence suggesting a direct link between pharmacodynamic nonequivalence of generic vancomycin and promotion of resistance in Staphylococcus aureus. To find out if even subtle deviations from the expected pharmacodynamic behavior with respect to the innovator could favor resistance, we studied a generic product of piperacillin-tazobactam characterized by pharmaceutical and pharmacokinetic equivalence but a faulty fit of Hill’s Emax sigmoid model that could be interpreted as pharmacodynamic nonequivalence. We determined the impact in vivo of this generic product on the resistance of a mixed Escherichia coli population composed of ∼99% susceptible cells (ATCC 35218 strain) and a ∼1% isogenic resistant subpopulation that overproduces TEM-1 β-lactamase. After only 24 hours of treatment in the neutropenic murine thigh infection model, the generic amplified the resistant subpopulation up to 20-times compared with the innovator, following an inverted-U dose-response relationship. These findings highlight the critical role of therapeutic nonequivalence of generic antibiotics as a key factor contributing to the global problem of bacterial resistance. PMID:27191163

  7. Closed-Loop Control and Advisory Mode Evaluation of an Artificial Pancreatic β Cell: Use of Proportional–Integral–Derivative Equivalent Model-Based Controllers

    PubMed Central

    Percival, Matthew W.; Zisser, Howard; Jovanovič, Lois; Doyle, Francis J.

    2008-01-01

    Background Using currently available technology, it is possible to apply modern control theory to produce a closed-loop artificial β cell. Novel use of established control techniques would improve glycemic control, thereby reducing the complications of diabetes. Two popular controller structures, proportional–integral–derivative (PID) and model predictive control (MPC), are compared first in a theoretical sense and then in two applications. Methods The Bergman model is transformed for use in a PID equivalent model-based controller. The internal model control (IMC) structure, which makes explicit use of the model, is compared with the PID controller structure in the transfer function domain. An MPC controller is then developed as an optimization problem with restrictions on its tuning parameters and is shown to be equivalent to an IMC controller. The controllers are tuned for equivalent performance and evaluated in a simulation study as a closed-loop controller and in an advisory mode scenario on retrospective clinical data. Results Theoretical development shows conditions under which PID and MPC controllers produce equivalent output via IMC. The simulation study showed that the single tuning parameter for the equivalent controllers relates directly to the closed-loop speed of response and robustness, an important result considering system uncertainty. The risk metric allowed easy identification of instances of inadequate control. Results of the advisory mode simulation showed that suitable tuning produces consistently appropriate delivery recommendations. Conclusion The conditions under which PID and MPC are equivalent have been derived. The MPC framework is more suitable given the extensions necessary for a fully closed-loop artificial β cell, such as consideration of controller constraints. Formulation of the control problem in risk space is attractive, as it explicitly addresses the asymmetry of the problem; this is done easily with MPC. PMID:19885240

  8. Integration of local motion is normal in amblyopia

    NASA Astrophysics Data System (ADS)

    Hess, Robert F.; Mansouri, Behzad; Dakin, Steven C.; Allen, Harriet A.

    2006-05-01

    We investigate the global integration of local motion direction signals in amblyopia, in a task where performance is equated between normal and amblyopic eyes at the single element level. We use an equivalent noise model to derive the parameters of internal noise and number of samples, both of which we show are normal in amblyopia for this task. This result is in apparent conflict with a previous study in amblyopes showing that global motion processing is defective in global coherence tasks [Vision Res. 43, 729 (2003)]. A similar discrepancy between the normalcy of signal integration [Vision Res. 44, 2955 (2004)] and anomalous global coherence form processing has also been reported [Vision Res. 45, 449 (2005)]. We suggest that these discrepancies for form and motion processing in amblyopia point to a selective problem in separating signal from noise in the typical global coherence task.

  9. Fully-kinetic Ion Simulation of Global Electrostatic Turbulent Transport in C-2U

    NASA Astrophysics Data System (ADS)

    Fulton, Daniel; Lau, Calvin; Bao, Jian; Lin, Zhihong; Tajima, Toshiki; TAE Team

    2017-10-01

    Understanding the nature of particle and energy transport in field-reversed configuration (FRC) plasmas is a crucial step towards an FRC-based fusion reactor. The C-2U device at Tri Alpha Energy (TAE) achieved macroscopically stable plasmas and electron energy confinement time which scaled favorably with electron temperature. This success led to experimental and theoretical investigation of turbulence in C-2U, including gyrokinetic ion simulations with the Gyrokinetic Toroidal Code (GTC). A primary objective of TAE's new C-2W device is to explore transport scaling in an extended parameter regime. In concert with the C-2W experimental campaign, numerical efforts have also been extended in A New Code (ANC) to use fully-kinetic (FK) ions and a Vlasov-Poisson field solver. Global FK ion simulations are presented. Future code development is also discussed.

  10. On Verifying Currents and Other Features in the Hawaiian Islands Region Using Fully Coupled Ocean/Atmosphere Mesoscale Prediction System Compared to Global Ocean Model and Ocean Observations

    NASA Astrophysics Data System (ADS)

    Jessen, P. G.; Chen, S.

    2014-12-01

    This poster introduces and evaluates features concerning the Hawaii, USA region using the U.S. Navy's fully Coupled Ocean/Atmosphere Mesoscale Prediction System (COAMPS-OS™) coupled to the Navy Coastal Ocean Model (NCOM). It also outlines some challenges in verifying ocean currents in the open ocean. The system is evaluated using in situ ocean data and initial forcing fields from the operational global Hybrid Coordinate Ocean Model (HYCOM). Verification shows difficulties in modelling downstream currents off the Hawaiian islands (Hawaii's wake). Comparing HYCOM to NCOM current fields show some displacement of small features such as eddies. Generally, there is fair agreement from HYCOM to NCOM in salinity and temperature fields. There is good agreement in SSH fields.

  11. Validation of an MRI Brain Injury and Growth Scoring System in Very Preterm Infants Scanned at 29- to 35-Week Postmenstrual Age.

    PubMed

    George, J M; Fiori, S; Fripp, J; Pannek, K; Bursle, J; Moldrich, R X; Guzzetta, A; Coulthard, A; Ware, R S; Rose, S E; Colditz, P B; Boyd, R N

    2017-07-01

    The diagnostic and prognostic potential of brain MR imaging before term-equivalent age is limited until valid MR imaging scoring systems are available. This study aimed to validate an MR imaging scoring system of brain injury and impaired growth for use at 29 to 35 weeks postmenstrual age in infants born at <31 weeks gestational age. Eighty-three infants in a prospective cohort study underwent early 3T MR imaging between 29 and 35 weeks' postmenstrual age (mean, 32 +2 ± 1 +3 weeks; 49 males, born at median gestation of 28 +4 weeks; range, 23 +6 -30 +6 weeks; mean birthweight, 1068 ± 312 g). Seventy-seven infants had a second MR scan at term-equivalent age (mean, 40 +6 ± 1 +3 weeks). Structural images were scored using a modified scoring system which generated WM, cortical gray matter, deep gray matter, cerebellar, and global scores. Outcome at 12-months corrected age (mean, 12 months 4 days ± 1 +2 weeks) consisted of the Bayley Scales of Infant and Toddler Development, 3rd ed. (Bayley III), and the Neuro-Sensory Motor Developmental Assessment. Early MR imaging global, WM, and deep gray matter scores were negatively associated with Bayley III motor (regression coefficient for global score β = -1.31; 95% CI, -2.39 to -0.23; P = .02), cognitive (β = -1.52; 95% CI, -2.39 to -0.65; P < .01) and the Neuro-Sensory Motor Developmental Assessment outcomes (β = -1.73; 95% CI, -3.19 to -0.28; P = .02). Early MR imaging cerebellar scores were negatively associated with the Neuro-Sensory Motor Developmental Assessment (β = -5.99; 95% CI, -11.82 to -0.16; P = .04). Results were reconfirmed at term-equivalent-age MR imaging. This clinically accessible MR imaging scoring system is valid for use at 29 to 35 weeks postmenstrual age in infants born very preterm. It enables identification of infants at risk of adverse outcomes before the current standard of term-equivalent age. © 2017 by American Journal of Neuroradiology.

  12. Global transport calculations with an equivalent barotropic system

    NASA Technical Reports Server (NTRS)

    Salby, Murry L.; O'Sullivan, Donal; Garcia, Rolando R.; Tribbia, Joseph

    1990-01-01

    Transport properties of the two-dimensional equations governing equivalent barotropic motion are investigated on the sphere. This system has ingredients such as forcing, equivalent depth, and thermal dissipation explicitly represented, and takes into account compression effects associated with vertical motion along isentropic surfaces. Horizontal transport properties of this system are investigated under adiabatic and diabatic conditions for different forms of dissipation, and over a range of resolutions. It is shown that forcing represetative of time-mean and amplified conditions at 10 mb leads to the behavior typical of observations at this level. The displacement of the polar night vortex and its distortion into a comma shape are evident, as is irreversible mixing under sufficiently strong forcing amplitude. It is shown that thermal dissipation influences the behavior significantly by inhibiting the amplification of unstable eddies and thereby the horizontal stirring of air.

  13. GLOBAL PROPERTIES OF FULLY CONVECTIVE ACCRETION DISKS FROM LOCAL SIMULATIONS

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Bodo, G.; Ponzo, F.; Rossi, P.

    2015-08-01

    We present an approach to deriving global properties of accretion disks from the knowledge of local solutions derived from numerical simulations based on the shearing box approximation. The approach consists of a two-step procedure. First, a local solution valid for all values of the disk height is constructed by piecing together an interior solution obtained numerically with an analytical exterior radiative solution. The matching is obtained by assuming hydrostatic balance and radiative equilibrium. Although in principle the procedure can be carried out in general, it simplifies considerably when the interior solution is fully convective. In these cases, the construction ismore » analogous to the derivation of the Hayashi tracks for protostars. The second step consists of piecing together the local solutions at different radii to obtain a global solution. Here we use the symmetry of the solutions with respect to the defining dimensionless numbers—in a way similar to the use of homology relations in stellar structure theory—to obtain the scaling properties of the various disk quantities with radius.« less

  14. Automatic bone detection and soft tissue aware ultrasound-CT registration for computer-aided orthopedic surgery.

    PubMed

    Wein, Wolfgang; Karamalis, Athanasios; Baumgartner, Adrian; Navab, Nassir

    2015-06-01

    The transfer of preoperative CT data into the tracking system coordinates within an operating room is of high interest for computer-aided orthopedic surgery. In this work, we introduce a solution for intra-operative ultrasound-CT registration of bones. We have developed methods for fully automatic real-time bone detection in ultrasound images and global automatic registration to CT. The bone detection algorithm uses a novel bone-specific feature descriptor and was thoroughly evaluated on both in-vivo and ex-vivo data. A global optimization strategy aligns the bone surface, followed by a soft tissue aware intensity-based registration to provide higher local registration accuracy. We evaluated the system on femur, tibia and fibula anatomy in a cadaver study with human legs, where magnetically tracked bone markers were implanted to yield ground truth information. An overall median system error of 3.7 mm was achieved on 11 datasets. Global and fully automatic registration of bones aquired with ultrasound to CT is feasible, with bone detection and tracking operating in real time for immediate feedback to the surgeon.

  15. Globalization and Inequality: Explaining American Exceptionalism

    PubMed Central

    Massey, Douglas S.

    2013-01-01

    Globalization creates pressure for greater inequality throughout the world, but these pressures are expressed more fully in the United States than in other developed nations. Although the distribution of US income before taxes is no more unequal than other nations, after taxes it is considerably less egalitarian. This occurs because of specific institutional arrangements that fail to redistribute income effectively and allow the pressures of globalization to be fully realized. These arrangements represent a shift from the past and were deliberately enacted over the past two decades with divergent consequences for those at the top and bottom of the socioeconomic hierarchy. The realignment of the US political economy can ultimately be traced to America’s legacy of racism. Once leaders in the Democratic party sought to include African Americans in the benefits of Roosevelt’s New Deal, support for economic populism evaporated in the middle and working classes. The advantage of the wealth is further enhanced by a political system in which those with money are better able to have their interests served legislatively than the poor or working classes. PMID:24298198

  16. Globalization and Inequality: Explaining American Exceptionalism.

    PubMed

    Massey, Douglas S

    2009-01-01

    Globalization creates pressure for greater inequality throughout the world, but these pressures are expressed more fully in the United States than in other developed nations. Although the distribution of US income before taxes is no more unequal than other nations, after taxes it is considerably less egalitarian. This occurs because of specific institutional arrangements that fail to redistribute income effectively and allow the pressures of globalization to be fully realized. These arrangements represent a shift from the past and were deliberately enacted over the past two decades with divergent consequences for those at the top and bottom of the socioeconomic hierarchy. The realignment of the US political economy can ultimately be traced to America's legacy of racism. Once leaders in the Democratic party sought to include African Americans in the benefits of Roosevelt's New Deal, support for economic populism evaporated in the middle and working classes. The advantage of the wealth is further enhanced by a political system in which those with money are better able to have their interests served legislatively than the poor or working classes.

  17. Politicizing Critical Pedagogies for the Logic of Late Capitalism

    ERIC Educational Resources Information Center

    Rice, J. A.

    2008-01-01

    In current critical pedagogy theory, the term "globalization" frequently signifies the rapid homogenization and structural equivalency of material and intellectual differences into a unified, transnational, capitalist rationality. For many composition scholars, this homogeneity signals an interpellation of not just subjects, but any and…

  18. Distinguished Lecture Series - Balancing the Energy & Climate Budget

    ScienceCinema

    None

    2017-12-09

    The average American uses 11400 Watts of power continuously. This is the equivalent of burning 114 x100 Watt light bulbs, all the time. The average person globally uses 2255 Watts of power, or a little less than 23 x100 Watt light bulbs.

  19. Non-local sub-characteristic zones of influence in unsteady interactive boundary-layers

    NASA Technical Reports Server (NTRS)

    Rothmayer, A. P.

    1992-01-01

    The properties of incompressible, unsteady, interactive, boundary layers are examined for a model hypersonic boundary layer and internal flow past humps or, equivalently, external flow past short-scaled humps. Using a linear high frequency analysis, it is shown that the domains of dependence within the viscous sublayer may be a strong function of position within the sublayer and may be strongly influenced by the pressure displacement interaction, or the prescribed displacement condition. Detailed calculations are presented for the hypersonic boundary layer. This effect is found to carry over directly to the fully viscous problem as well as the nonlinear problem. In the fully viscous problem, the non-local character of the domains of dependence manifests itself in the sub-characteristics. Potential implications of the domain of dependence structure on finite difference computations of unsteady boundary layers are briefly discussed.

  20. Fully Implanted Brain-Computer Interface in a Locked-In Patient with ALS.

    PubMed

    Vansteensel, Mariska J; Pels, Elmar G M; Bleichner, Martin G; Branco, Mariana P; Denison, Timothy; Freudenburg, Zachary V; Gosselaar, Peter; Leinders, Sacha; Ottens, Thomas H; Van Den Boom, Max A; Van Rijen, Peter C; Aarnoutse, Erik J; Ramsey, Nick F

    2016-11-24

    Options for people with severe paralysis who have lost the ability to communicate orally are limited. We describe a method for communication in a patient with late-stage amyotrophic lateral sclerosis (ALS), involving a fully implanted brain-computer interface that consists of subdural electrodes placed over the motor cortex and a transmitter placed subcutaneously in the left side of the thorax. By attempting to move the hand on the side opposite the implanted electrodes, the patient accurately and independently controlled a computer typing program 28 weeks after electrode placement, at the equivalent of two letters per minute. The brain-computer interface offered autonomous communication that supplemented and at times supplanted the patient's eye-tracking device. (Funded by the Government of the Netherlands and the European Union; ClinicalTrials.gov number, NCT02224469 .).

  1. Global Collaborative STEM Education

    NASA Astrophysics Data System (ADS)

    Meabh Kelly, Susan; Smith, Walter

    2016-04-01

    Global Collaborative STEM Education, as the name suggests, simultaneously supports two sets of knowledge and skills. The first set is STEM -- science, technology, engineering and math. The other set of content knowledge and skills is that of global collaboration. Successful global partnerships require awareness of one's own culture, the biases embedded within that culture, as well as developing awareness of the collaborators' culture. Workforce skills fostered include open-mindedness, perseverance when faced with obstacles, and resourceful use of technological "bridges" to facilitate and sustain communication. In respect for the 2016 GIFT Workshop focus, Global Collaborative STEM Education projects dedicated to astronomy research will be presented. The projects represent different benchmarks within the Global Collaborative STEM Education continuum, culminating in an astronomy research experience that fully reflects how the global STEM workforce collaborates. To facilitate wider engagement in Global Collaborative STEM Education, project summaries, classroom resources and contact information for established international collaborative astronomy research projects will be disseminated.

  2. Aspiring to Spectral Ignorance in Earth Observation

    NASA Astrophysics Data System (ADS)

    Oliver, S. A.

    2016-12-01

    Enabling robust, defensible and integrated decision making in the Era of Big Earth Data requires the fusion of data from multiple and diverse sensor platforms and networks. While the application of standardised global grid systems provides a common spatial analytics framework that facilitates the computationally efficient and statistically valid integration and analysis of these various data sources across multiple scales, there remains the challenge of sensor equivalency; particularly when combining data from different earth observation satellite sensors (e.g. combining Landsat and Sentinel-2 observations). To realise the vision of a sensor ignorant analytics platform for earth observation we require automation of spectral matching across the available sensors. Ultimately, the aim is to remove the requirement for the user to possess any sensor knowledge in order to undertake analysis. This paper introduces the concept of spectral equivalence and proposes a methodology through which equivalent bands may be sourced from a set of potential target sensors through application of equivalence metrics and thresholds. A number of parameters can be used to determine whether a pair of spectra are equivalent for the purposes of analysis. A baseline set of thresholds for these parameters and how to apply them systematically to enable relation of spectral bands amongst numerous different sensors is proposed. The base unit for comparison in this work is the relative spectral response. From this input, determination of a what may constitute equivalence can be related by a user, based on their own conceptualisation of equivalence.

  3. Using force-based adaptive resolution simulations to calculate solvation free energies of amino acid sidechain analogues

    NASA Astrophysics Data System (ADS)

    Fiorentini, Raffaele; Kremer, Kurt; Potestio, Raffaello; Fogarty, Aoife C.

    2017-06-01

    The calculation of free energy differences is a crucial step in the characterization and understanding of the physical properties of biological molecules. In the development of efficient methods to compute these quantities, a promising strategy is that of employing a dual-resolution representation of the solvent, specifically using an accurate model in the proximity of a molecule of interest and a simplified description elsewhere. One such concurrent multi-resolution simulation method is the Adaptive Resolution Scheme (AdResS), in which particles smoothly change their resolution on-the-fly as they move between different subregions. Before using this approach in the context of free energy calculations, however, it is necessary to make sure that the dual-resolution treatment of the solvent does not cause undesired effects on the computed quantities. Here, we show how AdResS can be used to calculate solvation free energies of small polar solutes using Thermodynamic Integration (TI). We discuss how the potential-energy-based TI approach combines with the force-based AdResS methodology, in which no global Hamiltonian is defined. The AdResS free energy values agree with those calculated from fully atomistic simulations to within a fraction of kBT. This is true even for small atomistic regions whose size is on the order of the correlation length, or when the properties of the coarse-grained region are extremely different from those of the atomistic region. These accurate free energy calculations are possible because AdResS allows the sampling of solvation shell configurations which are equivalent to those of fully atomistic simulations. The results of the present work thus demonstrate the viability of the use of adaptive resolution simulation methods to perform free energy calculations and pave the way for large-scale applications where a substantial computational gain can be attained.

  4. Design, Implementation, and Characterization of a Dedicated Breast Computed Mammo Tomography System for Enhanced Lesion Imaging

    DTIC Science & Technology

    2007-03-01

    common FOV of each system. 64 SPECT System Our current emission tomography system uses a compact 16x20cm 2 field of view Cadmium Zinc Telluride (CZT...Brzymialkiewicz, M.P. Tornai, R.L. McKinley, J.E. Bowsher. “Evaluation of Fully 3D Emission Mammotomography with a Compact Cadmium Zinc Telluride Detector...conclusions. Stacks of breast tissue equivalent plates, each 2.0cm thick (CIRS Inc., Norfolk, VA) having either 100% glandular or 100% adipose composition

  5. General purpose molecular dynamics simulations fully implemented on graphics processing units

    NASA Astrophysics Data System (ADS)

    Anderson, Joshua A.; Lorenz, Chris D.; Travesset, A.

    2008-05-01

    Graphics processing units (GPUs), originally developed for rendering real-time effects in computer games, now provide unprecedented computational power for scientific applications. In this paper, we develop a general purpose molecular dynamics code that runs entirely on a single GPU. It is shown that our GPU implementation provides a performance equivalent to that of fast 30 processor core distributed memory cluster. Our results show that GPUs already provide an inexpensive alternative to such clusters and discuss implications for the future.

  6. Macroscopic constitutive equations of thermo-poroelasticity derived using eigenstrain-eigenstress approaches

    NASA Astrophysics Data System (ADS)

    Suvorov, Alexander P.; Selvadurai, A. P. S.

    2011-06-01

    Macroscopic constitutive equations for thermoelastic processes in a fluid-saturated porous medium are re-derived using the notion of eigenstrain or, equivalently, eigenstress. The eigenstrain-stress approach is frequently used in micromechanics of solid multi-phase materials, such as composites. Simple derivations of the stress-strain constitutive relations and the void occupancy relationship are presented for both fully saturated and partially saturated porous media. Governing coupled equations for the displacement components and the fluid pressure are also obtained.

  7. Chapter 1: Introduction and Summary

    USDA-ARS?s Scientific Manuscript database

    In 2013, total U.S. greenhouse gas emissions measured 6,673 million metric tons of carbon dioxide equivalents (MMT CO2 eq.), rising 5.9 percent from 1990 estimates. Global concentrations of the three most important long-lived greenhouse gases (GHG) in the atmosphere have increased measurably since t...

  8. CRaTER Cosmic Ray Telescope

    Science.gov Websites

    Rays Solar Proton Events Biological Effects of Radiation News Recent News Journal Articles Science for the Effects of Radiation. CRaTER characterizes the global lunar radiation environment and its orbit. Investigate the effects of shielding by measuring LET spectra behind tissue-equivalent plastic

  9. 77 FR 1957 - New Postal Product

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-12

    ... Notice of Filing Two Functionally Equivalent Global Plus 2C Contracts Negotiated Service Agreements and Application for Non-Public Treatment of Materials Filed Under Seal, December 30, 2011 (Notice). See also... documents, under seal. Attachment 1 to the Notice is an application for non-public treatment of this...

  10. 77 FR 2098 - New Postal Product

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-13

    ... Competitive Products List and Notice of Filing Two Functionally Equivalent Global Plus 1C Contracts Negotiated Service Agreements and Application for Non-Public Treatment of Materials Filed Under Seal, December 30... under seal. Attachment 1 to the Notice is an application for non-public treatment of that material...

  11. Calculation of Transient Potential Rise on the Wind Turbine Struck by Lightning

    PubMed Central

    Xiaoqing, Zhang

    2014-01-01

    A circuit model is proposed in this paper for calculating the transient potential rise on the wind turbine struck by lightning. The model integrates the blade, sliding contact site, and tower and grounding system of the wind turbine into an equivalent circuit. The lightning current path from the attachment point to the ground can be fully described by the equivalent circuit. The transient potential responses are obtained in the different positions on the wind turbine by solving the circuit equations. In order to check the validity of the model, the laboratory measurement is made with a reduced-scale wind turbine. The measured potential waveform is compared with the calculated one and a better agreement is shown between them. The practical applicability of the model is also examined by a numerical example of a 2 MW Chinese-built wind turbine. PMID:25254231

  12. Establishing an NP-staffed minor emergency area.

    PubMed

    Buchanan, L; Powers, R D

    1997-04-01

    Patients with problems of high acuity need fully trained emergency physicians and nurses. Some patients with nonurgent problems can be cared for within the emergency department (ED) in a lower-cost setting designed and staffed specifically for this purpose. Staffing a fast track or minor emergency area (MEA) with nurse practitioners (NPs) is one way to satisfy the ED's care needs. One site analysis of the effectiveness of NPs indicates that patients are satisfied with their care, that nurses' interpersonal skills are better than those of physicians, that technical skills are equivalent, that patient outcomes are equivalent or superior and that NPs improve access to care. A nurse practitioner-staffed minor emergency area provides high quality care for approximately 21% of this site's adult emergency department population. Patients are triaged based on set criteria, allowing for short treatment times. The physical layout, triage criteria, and the NPs' scope of practice in the level 1 trauma center's ED are detailed.

  13. Longitudinal Regional Brain Development and Clinical Risk Factors in Extremely Preterm Infants.

    PubMed

    Kersbergen, Karina J; Makropoulos, Antonios; Aljabar, Paul; Groenendaal, Floris; de Vries, Linda S; Counsell, Serena J; Benders, Manon J N L

    2016-11-01

    To investigate third-trimester extrauterine brain growth and correlate this with clinical risk factors in the neonatal period, using serially acquired brain tissue volumes in a large, unselected cohort of extremely preterm born infants. Preterm infants (gestational age <28 weeks) underwent brain magnetic resonance imaging (MRI) at around 30 weeks postmenstrual age and again around term equivalent age. MRIs were segmented in 50 different regions covering the entire brain. Multivariable regression analysis was used to determine the influence of clinical variables on volumes at both scans, as well as on volumetric growth. MRIs at term equivalent age were available for 210 infants and serial data were available for 131 infants. Growth over these 10 weeks was greatest for the cerebellum, with an increase of 258%. Sex, birth weight z-score, and prolonged mechanical ventilation showed global effects on brain volumes on both scans. The effect of brain injury on ventricular size was already visible at 30 weeks, whereas growth data and volumes at term-equivalent age revealed the effect of brain injury on the cerebellum. This study provides data about third-trimester extrauterine volumetric brain growth in preterm infants. Both global and local effects of several common clinical risk factors were found to influence serial volumetric measurements, highlighting the vulnerability of the human brain, especially in the presence of brain injury, during this period. Copyright © 2016 Elsevier Inc. All rights reserved.

  14. Identification of Interesting Objects in Large Spectral Surveys Using Highly Parallelized Machine Learning

    NASA Astrophysics Data System (ADS)

    Škoda, Petr; Palička, Andrej; Koza, Jakub; Shakurova, Ksenia

    2017-06-01

    The current archives of LAMOST multi-object spectrograph contain millions of fully reduced spectra, from which the automatic pipelines have produced catalogues of many parameters of individual objects, including their approximate spectral classification. This is, however, mostly based on the global shape of the whole spectrum and on integral properties of spectra in given bandpasses, namely presence and equivalent width of prominent spectral lines, while for identification of some interesting object types (e.g. Be stars or quasars) the detailed shape of only a few lines is crucial. Here the machine learning is bringing a new methodology capable of improving the reliability of classification of such objects even in boundary cases. We present results of Spark-based semi-supervised machine learning of LAMOST spectra attempting to automatically identify the single and double-peak emission of Hα line typical for Be and B[e] stars. The labelled sample was obtained from archive of 2m Perek telescope at Ondřejov observatory. A simple physical model of spectrograph resolution was used in domain adaptation to LAMOST training domain. The resulting list of candidates contains dozens of Be stars (some are likely yet unknown), but also a bunch of interesting objects resembling spectra of quasars and even blazars, as well as many instrumental artefacts. The verification of a nature of interesting candidates benefited considerably from cross-matching and visualisation in the Virtual Observatory environment.

  15. Mango (Mangifera indica L.) Polyphenols Ameliorate Functional Constipation Symptoms in Humans Beyond Equivalent Amount of Fiber.

    PubMed

    P Venancio, Vinicius; Kim, Hyemee; A Sirven, Maritza; D Tekwe, Carmen; Honvoh, Gilson; T Talcott, Stephen; U Mertens-Talcott, Susanne

    2018-05-07

    Chronic constipation is a common gastrointestinal condition associated with intestinal inflammation and considerably impaired quality of life, affecting about 20% of Americans. Dietary fiber and laxatives aid in its treatment but do not fully address all symptoms, such as intestinal inflammation. Mango (Mangifera indica L.), a fiber- and polyphenol-rich fruit may provide anti-inflammatory effects in constipation. The 4-week consumption of mango fruit (300 g) or the equivalent amount of fiber was investigated in otherwise healthy human volunteers with chronic constipation that were randomly assigned to either group. Blood and fecal samples and digestive wellness questionnaires were collected at the beginning and end of the study. Results show that mango consumption significantly improved constipation status (stool frequency, consistency, and shape) and increased gastrin levels and fecal concentrations of short chain fatty acid (valeric acid) while lowering endotoxin and interleukin 6 concentrations in plasma. In this pilot study, the consumption of mango improves symptoms and associated biomarkers of constipation beyond an equivalent amount of fiber. Larger follow-up studies would need to investigate biomarkers for intestinal inflammation in more detail. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

  16. Exploring the Inner Edge of the Habitable Zone with Fully Coupled Oceans

    NASA Technical Reports Server (NTRS)

    Way, M.J; Del Genio, A.D.; Kelley, M.; Aleinov, I.; Clune, T.

    2015-01-01

    The role of rotation in planetary atmospheres plays an important role in regulating atmospheric and oceanic heat flow, cloud formation and precipitation. Using the Goddard Institute for Space Studies (GISS) three dimension General Circulation Model (3D-GCM) we demonstrate how varying rotation rate and increasing the incident solar flux on a planet are related to each other and may allow the inner edge of the habitable zone to be much closer than many previous habitable zone studies have indicated. This is shown in particular for fully coupled ocean runs -- some of the first that have been utilized in this context. Results with a 100m mixed layer depth and our fully coupled ocean runs are compared with those of Yang et al. 2014, which demonstrates consistency across models. However, there are clear differences for rotations rates of 1-16x present earth day lengths between the mixed layer and fully couple ocean models, which points to the necessity of using fully coupled oceans whenever possible. The latter was recently demonstrated quite clearly by Hu & Yang 2014 in their aquaworld study with a fully coupled ocean when compared with similar mixed layer ocean studies and by Cullum et al. 2014. Atmospheric constituent amounts were also varied alongside adjustments to cloud parameterizations (results not shown here). While the latter have an effect on what a planet's global mean temperature is once the oceans reach equilibrium they do not qualitatively change the overall relationship between the globally averaged surface temperature and incident solar flux for rotation rates ranging from 1 to 256 times the present Earth day length. At the same time this study demonstrates that given the lack of knowledge about the atmospheric constituents and clouds on exoplanets there is still a large uncertainty as to where a planet will sit in a given star's habitable zone.

  17. Greenland ice sheet beyond 2100: Simulating its evolution and influence using the coupled climate-ice sheet model EC-Earth - PISM

    NASA Astrophysics Data System (ADS)

    Yang, S.; Christensen, J. H.; Madsen, M. S.; Ringgaard, I. M.; Petersen, R. A.; Langen, P. P.

    2017-12-01

    Greenland ice sheet (GrIS) is observed undergoing a rapid change in the recent decades, with an increasing area of surface melting and ablation and a speeding mass loss. Predicting the GrIS changes and their climate consequences relies on the understanding of the interaction of the GrIS with the climate system on both global and local scales, and requires climate model systems incorporating with an explicit and physically consistent ice sheet module. In this work we study the GrIS evolution and its interaction with the climate system using a fully coupled global climate model with a dynamical ice sheet model for the GrIS. The coupled model system, EC-EARTH - PISM, consisting of the atmosphere-ocean-sea ice model system EC-EARTH, and the Parallel Ice Sheet Model (PISM), has been employed for a 1400-year simulation forced by CMIP5 historical forcing from 1850 to 2005 and continued along an extended RCP8.5 scenario with the forcing peaking at 2200 and stabilized hereafter. The simulation reveals that, following the anthropogenic forcing increase, the global mean surface temperature rapidly rises about 10 °C in the 21st and 22nd century. After the forcing stops increasing after 2200, the temperature change slows down and eventually stabilizes at about 12.5 °C above the preindustrial level. In response to the climate warming, the GrIS starts losing mass slowly in the 21st century, but the ice retreat accelerates substantially after 2100 and ice mass loss continues hereafter at a constant rate of approximately 0.5 m sea level rise equivalence per 100 years, even as the warming rate gradually levels off. Ultimately the volume and extent of GrIS reduce to less than half of its preindustrial value. To understand the interaction of GrIS with the climate system, the characteristics of atmospheric and oceanic circulation in the warm climate are analyzed. The circulation patterns associated with the negative surface mass balance that leads to GrIS retreat are investigated. The impact of the simulated surface warming on the ice flow and ice dynamics is explored.

  18. Five-minute, 1/2°, and 1° data sets of continental watersheds and river networks for use in regional and global hydrologic and climate system modeling studies

    NASA Astrophysics Data System (ADS)

    Graham, S. T.; Famiglietti, J. S.; Maidment, D. R.

    1999-02-01

    A major shortcoming of the land surface component in climate models is the absence of a river transport algorithm. This issue becomes particularly important in fully coupled climate system models (CSMs), where river transport is required to close and realistically represent the global water cycle. The development of a river transport algorithm requires knowledge of watersheds and river networks at a scale that is appropriate for use in CSMs. These data must be derived largely from global digital topographic information. The purpose of this paper is to describe a new data set of watersheds and river networks, which is derived primarily from the TerrainBase 5' Global DTM (digital terrain model) and the CIA World Data Bank II. These data serve as a base map for routing continental runoff to the appropriate coast and therefore into the appropriate ocean or inland sea. Using this data set, the runoff produced in any grid cell, when coupled with a routing algorithm, can easily be transported to the appropriate water body and distributed across that water body as desired. The data set includes watershed and flow direction information, as well as supporting hydrologic data at 5', 1/2°, and 1° resolutions globally. It will be useful in fully coupled land-ocean-atmosphere models, in terrestrial ecosystem models, or in stand-alone macroscale hydrologic-modeling studies.

  19. Characterizing the LANDSAT Global Long-Term Data Record

    NASA Technical Reports Server (NTRS)

    Arvidson, T.; Goward, S. N.; Williams, D. L.

    2006-01-01

    The effects of global climate change are fast becoming politically, sociologically, and personally important: increasing storm frequency and intensity, lengthening cycles of drought and flood, expanding desertification and soil salinization. A vital asset in the analysis of climate change on a global basis is the 34-year record of Landsat imagery. In recognition of its increasing importance, a detailed analysis of the Landsat observation coverage within the US archive was commissioned. Results to date indicate some unexpected gaps in the US-held archive. Fortunately, throughout the Landsat program, data have been downlinked routinely to International Cooperator (IC) ground stations for archival, processing, and distribution. These IC data could be combined with the current US holdings to build a nearly global, annual observation record over this 34-year period. Today, we have inadequate information as to which scenes are available from which IC archives. Our best estimate is that there are over four million digital scenes in the IC archives, compared with the nearly two million scenes held in the US archive. This vast pool of Landsat observations needs to be accurately documented, via metadata, to determine the existence of complementary scenes and to characterize the potential scope of the global Landsat observation record. Of course, knowing the extent and completeness of the data record is but the first step. It will be necessary to assure that the data record is easy to use, internally consistent in terms of calibration and data format, and fully accessible in order to fully realize its potential.

  20. Paris Agreement on Climate Change: A Booster to Enable Sustainable Global Development and Beyond.

    PubMed

    Bhore, Subhash Janardhan

    2016-11-14

    The global warming and its adverse effects on the atmosphere, the biosphere, the lithosphere, and the hydrosphere are obvious. Based on this fact, the international community is fully convinced that we need to fix the problem urgently for our survival, good health, and wellbeing. The aim of this article is to promote the awareness about the United Nations (UN) historic 'Paris Agreement on Climate Change (PACC)' which entered into-force on 4 November 2016. The expected impact of PACC on the global average temperature rise by 2100 as well as its role in enabling accomplishment of global sustainable development goals (SDGs) for the people and planet is also highlighted.

  1. Assessing Proposals for New Global Health Treaties: An Analytic Framework.

    PubMed

    Hoffman, Steven J; Røttingen, John-Arne; Frenk, Julio

    2015-08-01

    We have presented an analytic framework and 4 criteria for assessing when global health treaties have reasonable prospects of yielding net positive effects. First, there must be a significant transnational dimension to the problem being addressed. Second, the goals should justify the coercive nature of treaties. Third, proposed global health treaties should have a reasonable chance of achieving benefits. Fourth, treaties should be the best commitment mechanism among the many competing alternatives. Applying this analytic framework to 9 recent calls for new global health treaties revealed that none fully meet the 4 criteria. Efforts aiming to better use or revise existing international instruments may be more productive than is advocating new treaties.

  2. Assessing Proposals for New Global Health Treaties: An Analytic Framework

    PubMed Central

    Røttingen, John-Arne; Frenk, Julio

    2015-01-01

    We have presented an analytic framework and 4 criteria for assessing when global health treaties have reasonable prospects of yielding net positive effects. First, there must be a significant transnational dimension to the problem being addressed. Second, the goals should justify the coercive nature of treaties. Third, proposed global health treaties should have a reasonable chance of achieving benefits. Fourth, treaties should be the best commitment mechanism among the many competing alternatives. Applying this analytic framework to 9 recent calls for new global health treaties revealed that none fully meet the 4 criteria. Efforts aiming to better use or revise existing international instruments may be more productive than is advocating new treaties. PMID:26066926

  3. Paris Agreement on Climate Change: A Booster to Enable Sustainable Global Development and Beyond

    PubMed Central

    Bhore, Subhash Janardhan

    2016-01-01

    The global warming and its adverse effects on the atmosphere, the biosphere, the lithosphere, and the hydrosphere are obvious. Based on this fact, the international community is fully convinced that we need to fix the problem urgently for our survival, good health, and wellbeing. The aim of this article is to promote the awareness about the United Nations (UN) historic ‘Paris Agreement on Climate Change (PACC)’ which entered into-force on 4 November 2016. The expected impact of PACC on the global average temperature rise by 2100 as well as its role in enabling accomplishment of global sustainable development goals (SDGs) for the people and planet is also highlighted. PMID:27854248

  4. The collapse of the local, Spitzer-Haerm formulation and a global-local generalization for heat flow in an inhomogeneous, fully ionized plasma

    NASA Technical Reports Server (NTRS)

    Scudder, J. D.; Olbert, S.

    1983-01-01

    The breakdown of the classical (CBES) field aligned transport relations for electrons in an inhomogeneous, fully ionized plasma as a mathematical issue of radius of convergence is addressed, the finite Knudsen number conditions when CBES results are accurate is presented and a global-local (GL) way to describe the results of Coulomb physics moderated conduction that is more nearly appropriate for astrophysical plasmas are defined. This paper shows the relationship to and points of departure of the present work from the CBES approach. The CBES heat law in current use is shown to be an especially restrictive special case of the new, more general GL result. A preliminary evaluation of the dimensionless heat function, using analytic formulas, shows that the dimensionless heat function profiles versus density of the type necessary for a conduction supported high speed solar wind appear possible.

  5. The costs of climate change: ecosystem services and wildland fires

    EPA Science Inventory

    In this paper we use Habitat Equivalency Analysis (HEA) to monetize the avoided ecosystem services losses due to climate change-induced wildland fires in the U.S. Specifically, we use the U.S. Forest Service’s MC1 dynamic global vegetation model to forecast changes in wildland fi...

  6. 75 FR 79053 - New Postal Product

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-17

    ... POSTAL REGULATORY COMMISSION [Docket Nos. MC2011-7, CP2011-39 and CP2011-40; Order No. 607] New... Service seeks to add Global Plus 1B as a new product, to the competitive product list.\\1\\ The Request has... instant contracts be considered ``the new `baseline' contracts for future functional equivalency analyses...

  7. Multicultural Music Education: A National Profile of Elementary Schools

    ERIC Educational Resources Information Center

    Weidknecht, Marguerite K.

    2011-01-01

    Globalization and increased diversity within student populations results in a growing impetus toward a multicultural approach to music education. The National Standards in Music Education (MENC, 2010) requires that students experience the music of other cultures; however, not all multicultural music programs are equivalent in content, depth of…

  8. Commonwealth Degrees from Class to Equivalence: Changing to Grade Point Averages in the Caribbean

    ERIC Educational Resources Information Center

    Bastick, Tony

    2004-01-01

    British Commonwealth universities inherited the class system for classifying degrees. However, increasing global marketization has brought with it increasing demands for student exchanges, particularly with universities in North America. Hence, Commonwealth universities are considering adopting grade point averages (GPAs) for degree classification…

  9. Implementation of SEREP Into LLNL Dyna3d for Global/Local Analysis

    DTIC Science & Technology

    2005-08-01

    System Equivalent Reduction Expansion Process (SEREP). Presented at the 7th International Modal Analysis Conference, Las Vegas, NV, February 1989. 7...HUTCHINSON F SCHWARZ WARREN MI 48397-5000 14 BENET LABS AMSTA AR CCB R FISCELLA M SOJA E KATHE M SCAVULO G SPENCER P WHEELER

  10. Intercode comparison of gyrokinetic global electromagnetic modes

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Görler, T., E-mail: tobias.goerler@ipp.mpg.de; Tronko, N.; Hornsby, W. A.

    Aiming to fill a corresponding lack of sophisticated test cases for global electromagnetic gyrokinetic codes, a new hierarchical benchmark is proposed. Starting from established test sets with adiabatic electrons, fully gyrokinetic electrons, and electrostatic fluctuations are taken into account before finally studying the global electromagnetic micro-instabilities. Results from up to five codes involving representatives from different numerical approaches as particle-in-cell methods, Eulerian and Semi-Lagrangian are shown. By means of spectrally resolved growth rates and frequencies and mode structure comparisons, agreement can be confirmed on ion-gyro-radius scales, thus providing confidence in the correct implementation of the underlying equations.

  11. Ductile Tearing of Thin Aluminum Plates Under Blast Loading. Predictions with Fully Coupled Models and Biaxial Material Response Characterization

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Corona, Edmundo; Gullerud, Arne S.; Haulenbeek, Kimberly K.

    2015-06-01

    The work presented in this report concerns the response and failure of thin 2024- T3 aluminum alloy circular plates to a blast load produced by the detonation of a nearby spherical charge. The plates were fully clamped around the circumference and the explosive charge was located centrally with respect to the plate. The principal objective was to conduct a numerical model validation study by comparing the results of predictions to experimental measurements of plate deformation and failure for charges with masses in the vicinity of the threshold between no tearing and tearing of the plates. Stereo digital image correlation datamore » was acquired for all tests to measure the deflection and strains in the plates. The size of the virtual strain gage in the measurements, however, was relatively large, so the strain measurements have to be interpreted accordingly as lower bounds of the actual strains in the plate and of the severity of the strain gradients. A fully coupled interaction model between the blast and the deflection of the structure was considered. The results of the validation exercise indicated that the model predicted the deflection of the plates reasonably accurately as well as the distribution of strain on the plate. The estimation of the threshold charge based on a critical value of equivalent plastic strain measured in a bulge test, however, was not accurate. This in spite of efforts to determine the failure strain of the aluminum sheet under biaxial stress conditions. Further work is needed to be able to predict plate tearing with some degree of confidence. Given the current technology, at least one test under the actual blast conditions where the plate tears is needed to calibrate the value of equivalent plastic strain when failure occurs in the numerical model. Once that has been determined, the question of the explosive mass value at the threshold could be addressed with more confidence.« less

  12. Multiscale global identification of porous structures

    NASA Astrophysics Data System (ADS)

    Hatłas, Marcin; Beluch, Witold

    2018-01-01

    The paper is devoted to the evolutionary identification of the material constants of porous structures based on measurements conducted on a macro scale. Numerical homogenization with the RVE concept is used to determine the equivalent properties of a macroscopically homogeneous material. Finite element method software is applied to solve the boundary-value problem in both scales. Global optimization methods in form of evolutionary algorithm are employed to solve the identification task. Modal analysis is performed to collect the data necessary for the identification. A numerical example presenting the effectiveness of proposed attitude is attached.

  13. An efficient method for generalized linear multiplicative programming problem with multiplicative constraints.

    PubMed

    Zhao, Yingfeng; Liu, Sanyang

    2016-01-01

    We present a practical branch and bound algorithm for globally solving generalized linear multiplicative programming problem with multiplicative constraints. To solve the problem, a relaxation programming problem which is equivalent to a linear programming is proposed by utilizing a new two-phase relaxation technique. In the algorithm, lower and upper bounds are simultaneously obtained by solving some linear relaxation programming problems. Global convergence has been proved and results of some sample examples and a small random experiment show that the proposed algorithm is feasible and efficient.

  14. Combining virtual observatory and equivalent source dipole approaches to describe the geomagnetic field with Swarm measurements

    NASA Astrophysics Data System (ADS)

    Saturnino, Diana; Langlais, Benoit; Amit, Hagay; Civet, François; Mandea, Mioara; Beucler, Éric

    2018-03-01

    A detailed description of the main geomagnetic field and of its temporal variations (i.e., the secular variation or SV) is crucial to understanding the geodynamo. Although the SV is known with high accuracy at ground magnetic observatory locations, the globally uneven distribution of the observatories hampers the determination of a detailed global pattern of the SV. Over the past two decades, satellites have provided global surveys of the geomagnetic field which have been used to derive global spherical harmonic (SH) models through some strict data selection schemes to minimise external field contributions. However, discrepancies remain between ground measurements and field predictions by these models; indeed the global models do not reproduce small spatial scales of the field temporal variations. To overcome this problem we propose to directly extract time series of the field and its temporal variation from satellite measurements as it is done at observatory locations. We follow a Virtual Observatory (VO) approach and define a global mesh of VOs at satellite altitude. For each VO and each given time interval we apply an Equivalent Source Dipole (ESD) technique to reduce all measurements to a unique location. Synthetic data are first used to validate the new VO-ESD approach. Then, we apply our scheme to data from the first two years of the Swarm mission. For the first time, a 2.5° resolution global mesh of VO time series is built. The VO-ESD derived time series are locally compared to ground observations as well as to satellite-based model predictions. Our approach is able to describe detailed temporal variations of the field at local scales. The VO-ESD time series are then used to derive global spherical harmonic models. For a simple SH parametrization the model describes well the secular trend of the magnetic field both at satellite altitude and at the surface. As more data will be made available, longer VO-ESD time series can be derived and consequently used to study sharp temporal variation features, such as geomagnetic jerks.

  15. Structural Statics Analysis and Optimization Design of Regulating Device for Air Conveyer Outlet in Coal Mine

    NASA Astrophysics Data System (ADS)

    Gong, Xiaoyan; Li, Ying; Zhang, Yongqiang

    2018-06-01

    In view of the enlargement of fully mechanized face excavation and long distance driving, gas emission and dust production increase greatly. However, the current ventilation device direction angle, caliber and front-back distance cannot change dynamically at any time, resulting in the serious accumulation in the dead zone. In this paper, a new device were proposed that can solve above problems. Finite element ANSYS software were used to simulate and optimize the structural safety of the control device' key components. The optimization results showed that the equivalent stress decreases by 49%; after the optimization of deformation and mass are 0.829mm and 0.548kg, which were 21% and 10% lower than before.The quality, safety, reliability and cost of the control device reach the expected standards perfectly, which can meet the requirements of safe ventilation and down-dusting of fully mechanized face.

  16. Performance assessment of a single-pixel compressive sensing imaging system

    NASA Astrophysics Data System (ADS)

    Du Bosq, Todd W.; Preece, Bradley L.

    2016-05-01

    Conventional electro-optical and infrared (EO/IR) systems capture an image by measuring the light incident at each of the millions of pixels in a focal plane array. Compressive sensing (CS) involves capturing a smaller number of unconventional measurements from the scene, and then using a companion process known as sparse reconstruction to recover the image as if a fully populated array that satisfies the Nyquist criteria was used. Therefore, CS operates under the assumption that signal acquisition and data compression can be accomplished simultaneously. CS has the potential to acquire an image with equivalent information content to a large format array while using smaller, cheaper, and lower bandwidth components. However, the benefits of CS do not come without compromise. The CS architecture chosen must effectively balance between physical considerations (SWaP-C), reconstruction accuracy, and reconstruction speed to meet operational requirements. To properly assess the value of such systems, it is necessary to fully characterize the image quality, including artifacts and sensitivity to noise. Imagery of the two-handheld object target set at range was collected using a passive SWIR single-pixel CS camera for various ranges, mirror resolution, and number of processed measurements. Human perception experiments were performed to determine the identification performance within the trade space. The performance of the nonlinear CS camera was modeled with the Night Vision Integrated Performance Model (NV-IPM) by mapping the nonlinear degradations to an equivalent linear shift invariant model. Finally, the limitations of CS modeling techniques will be discussed.

  17. Simultaneous reproduction of global carbon exchange and storage of terrestrial forest ecosystems

    NASA Astrophysics Data System (ADS)

    Kondo, M.; Ichii, K.

    2012-12-01

    Understanding the mechanism of the terrestrial carbon cycle is essential for assessing the impact of climate change. Quantification of both carbon exchange and storage is the key to the understanding, but it often associates with difficulties due to complex entanglement of environmental and physiological factors. Terrestrial ecosystem models have been the major tools to assess the terrestrial carbon budget for decades. Because of its strong association with climate change, carbon exchange has been more rigorously investigated by the terrestrial biosphere modeling community. Seeming success of model based assessment of carbon budge often accompanies with the ill effect, substantial misrepresentation of storage. In practice, a number of model based analyses have paid attention solely on terrestrial carbon fluxes and often neglected carbon storage such as forest biomass. Thus, resulting model parameters are inevitably oriented to carbon fluxes. This approach is insufficient to fully reduce uncertainties about future terrestrial carbon cycles and climate change because it does not take into account the role of biomass, which is equivalently important as carbon fluxes in the system of carbon cycle. To overcome this issue, a robust methodology for improving the global assessment of both carbon budget and storage is needed. One potentially effective approach to identify a suitable balance of carbon allocation proportions for each individual ecosystem. Carbon allocations can influence the plant growth by controlling the amount of investment acquired from photosynthesis, as well as carbon fluxes by controlling the carbon content of leaves and litter, both are active media for photosynthesis and decomposition. Considering those aspects, there may exist the suitable balance of allocation proportions enabling the simultaneous reproduction of carbon budget and storage. The present study explored the existence of such suitable balances of allocation proportions, and examines the performance of carbon fluxes and biomass simulations with them. An experiment was performed with a widely used model, Biome-BGC, and effects of disturbance and forest age were considered in the model run. As for disturbance, human influence index map derived by CIESIN was used. A global forest age map was prepared with model inversion method using CIESIN human influence index, GFED fire burnt area, and IIASA global forest biomass maps. To validate model GPP and RE, we prepared the global GPP map estimated with support vector machine and the global RE map derived by downscaling the carbon budget product (L4A) of Greenhouse gases Observing SATellite (GOSAT) in conjunction with IIASA biomass and soil carbon products. Through a process of testing the simultaneous reproducibility of the Biome-BGC model, it will be determined whether the current terrestrial ecosystem model is sophisticated enough for clarifying the mechanism of carbon cycle.

  18. Global Arrays

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Krishnamoorthy, Sriram; Daily, Jeffrey A.; Vishnu, Abhinav

    2015-11-01

    Global Arrays (GA) is a distributed-memory programming model that allows for shared-memory-style programming combined with one-sided communication, to create a set of tools that combine high performance with ease-of-use. GA exposes a relatively straightforward programming abstraction, while supporting fully-distributed data structures, locality of reference, and high-performance communication. GA was originally formulated in the early 1990’s to provide a communication layer for the Northwest Chemistry (NWChem) suite of chemistry modeling codes that was being developed concurrently.

  19. Update on the Global Campaign Against Terrorist Financing: Second Report of an Independent Task Force on Terrorist Financing

    DTIC Science & Technology

    2004-06-15

    therefore should be the subject of additional due diligence . Independent Task Force on Terrorist Financing 47 • Cooperate fully with any multilateral...unusually talented group who brought enthusiasm, diligence , and strong analytical skills to this project. We are especially appreciative of the hard...State Department’s latest Patterns of Global Terrorism report, continue to give praise where praise is due but too often go to lengths to avoid

  20. Competition of the connectivity with the local and the global order in polymer melts and crystals

    NASA Astrophysics Data System (ADS)

    Bernini, S.; Puosi, F.; Barucco, M.; Leporini, D.

    2013-11-01

    The competition between the connectivity and the local or global order in model fully flexible chain molecules is investigated by molecular-dynamics simulations. States with both missing (melts) and high (crystal) global order are considered. Local order is characterized within the first coordination shell (FCS) of a tagged monomer and found to be lower than in atomic systems in both melt and crystal. The role played by the bonds linking the tagged monomer to FCS monomers (radial bonds), and the bonds linking two FCS monomers (shell bonds) is investigated. The detailed analysis in terms of Steinhardt's orientation order parameters Ql (l = 2 - 10) reveals that increasing the number of shell bonds decreases the FCS order in both melt and crystal. Differently, the FCS arrangements organize the radial bonds. Even if the molecular chains are fully flexible, the distribution of the angle formed by adjacent radial bonds exhibits sharp contributions at the characteristic angles θ ≈ 70°, 122°, 180°. The fractions of adjacent radial bonds with θ ≈ 122°, 180° are enhanced by the global order of the crystal, whereas the fraction with 70° ≲ θ ≲ 110° is nearly unaffected by the crystallization. Kink defects, i.e., large lateral displacements of the chains, are evidenced in the crystalline state.

  1. Global health: A lasting partnership in paediatric surgery

    PubMed Central

    Lakhoo, Kokila; Msuya, David

    2015-01-01

    Background: To emphasise the value of on-going commitment in Global Health Partnerships. Materials and Methods: A hospital link, by invitation, was set up between United Kingdom and Tanzania since 2002. The project involved annual visits with activities ranging from exchange of skill to training health professionals. Furthermore, the programme attracted teaching and research activities. For continuity, there was electronic communication between visits. Results: Six paediatric surgeons are now fully trained with three further in training in Africa. Paediatric surgery services are now separate from adult services. Seven trainee exchanges have taken place with four awarded fellowships/scholarships. Twenty-three clinical projects have been presented internationally resulting in eight international publications. The programme has attracted other health professionals, especially nursing and engineering. The Tropical Health and Education Trust prize was recently achieved for nursing and radiography. National Health Service has benefited from volunteering staff bringing new cost-effective ideas. A fully funded medical student elective programme has been achieved since 2008. Conclusion: Global Health Partnerships are an excellent initiative in establishing specialist services in countries with limited resources. In the future, this will translate into improved patient care as long as it is sustained and valued by long term commitment. PMID:26168748

  2. Global health: A lasting partnership in paediatric surgery.

    PubMed

    Lakhoo, Kokila; Msuya, David

    2015-01-01

    To emphasise the value of on-going commitment in Global Health Partnerships. A hospital link, by invitation, was set up between United Kingdom and Tanzania since 2002. The project involved annual visits with activities ranging from exchange of skill to training health professionals. Furthermore, the programme attracted teaching and research activities. For continuity, there was electronic communication between visits. Six paediatric surgeons are now fully trained with three further in training in Africa. Paediatric surgery services are now separate from adult services. Seven trainee exchanges have taken place with four awarded fellowships/scholarships. Twenty-three clinical projects have been presented internationally resulting in eight international publications. The programme has attracted other health professionals, especially nursing and engineering. The Tropical Health and Education Trust prize was recently achieved for nursing and radiography. National Health Service has benefited from volunteering staff bringing new cost-effective ideas. A fully funded medical student elective programme has been achieved since 2008. Global Health Partnerships are an excellent initiative in establishing specialist services in countries with limited resources. In the future, this will translate into improved patient care as long as it is sustained and valued by long term commitment.

  3. Fully decentralized estimation and control for a modular wheeled mobile robot

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Mutambara, A.G.O.; Durrant-Whyte, H.F.

    2000-06-01

    In this paper, the problem of fully decentralized data fusion and control for a modular wheeled mobile robot (WMR) is addressed. This is a vehicle system with nonlinear kinematics, distributed multiple sensors, and nonlinear sensor models. The problem is solved by applying fully decentralized estimation and control algorithms based on the extended information filter. This is achieved by deriving a modular, decentralized kinematic model by using plane motion kinematics to obtain the forward and inverse kinematics for a generalized simple wheeled vehicle. This model is then used in the decentralized estimation and control algorithms. WMR estimation and control is thusmore » obtained locally using reduced order models with reduced communication of information between nodes is carried out after every measurement (full rate communication), the estimates and control signals obtained at each node are equivalent to those obtained by a corresponding centralized system. Transputer architecture is used as the basis for hardware and software design as it supports the extensive communication and concurrency requirements that characterize modular and decentralized systems. The advantages of a modular WMR vehicle include scalability, application flexibility, low prototyping costs, and high reliability.« less

  4. A fully implicit Hall MHD algorithm based on the ion Ohm's law

    NASA Astrophysics Data System (ADS)

    Chacón, Luis

    2010-11-01

    Hall MHD is characterized by extreme hyperbolic numerical stiffness stemming from fast dispersive waves. Implicit algorithms are potentially advantageous, but of very difficult efficient implementation due to the condition numbers of associated matrices. Here, we explore the extension of a successful fully implicit, fully nonlinear algorithm for resistive MHD,ootnotetextL. Chac'on, Phys. Plasmas, 15 (2008) based on Jacobian-free Newton-Krylov methods with physics-based preconditioning, to Hall MHD. Traditionally, Hall MHD has been formulated using the electron equation of motion (EOM) to determine the electric field in the plasma (the so-called Ohm's law). However, given that the center-of-mass EOM, the ion EOM, and the electron EOM are linearly dependent, one could equivalently employ the ion EOM as the Ohm's law for a Hall MHD formulation. While, from a physical standpoint, there is no a priori advantage for using one Ohm's law vs. the other, we argue in this poster that there is an algorithmic one. We will show that, while the electron Ohm's law prevents the extension of the resistive MHD preconditioning strategy to Hall MHD, an ion Ohm's law allows it trivially. Verification and performance numerical results on relevant problems will be presented.

  5. Transnational Education and the New Economy: Delivery and Quality. Studies on Higher Education.

    ERIC Educational Resources Information Center

    United Nations Educational, Scientific, and Cultural Organization, Bucharest (Romania). European Centre for Higher Education.

    This volume contains 17 papers based on presentations given at a conference on transnational education. These papers focus on academic recognition and the equivalence of academic qualifications. The papers in the first section, "Challenges for the New Economy--Reskilling and Retraining a Global Workforce," are: (1) "Industry-Based…

  6. The Australian Press and Education: A Survey of National and Global Perspectives.

    ERIC Educational Resources Information Center

    Woolman, David C.

    The news media are often the main source of public information about education. This paper analyzes press coverage of selected issues in contemporary Australian education. From December 28, 1998, to February 17, 1999, daily educational reporting was surveyed in "The Australian" (a paper roughly equivalent to "USA Today") and in…

  7. 76 FR 787 - Notice of Availability of the Recommended Toxicity Equivalence Factors (TEFs) for Human Health...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-06

    ... manufacturing, combustion, and metal processing. There is global contamination of air, soil and water with trace... food chain, and accumulate in the tissues of animals. Human exposures to these compounds occur primarily through eating contaminated foods. The health effects from exposures to dioxins and DLCs have been...

  8. Measurement Invariance in Mentoring Research: A Cross-Cultural Examination across Taiwan and the U.S.

    ERIC Educational Resources Information Center

    Hu, Changya; Pellegrini, Ekin K.; Scandura, Terri A.

    2011-01-01

    Workplace mentoring in the international context is an emerging research area with significant potential for global integration. However, although measurement equivalence is a prerequisite for examining cross-cultural differences, this assumption has yet to be examined in mentoring research. This study contributes to the mentoring literature by…

  9. Global CO2 emissions from cement production

    NASA Astrophysics Data System (ADS)

    Andrew, Robbie M.

    2018-01-01

    The global production of cement has grown very rapidly in recent years, and after fossil fuels and land-use change, it is the third-largest source of anthropogenic emissions of carbon dioxide. The required data for estimating emissions from global cement production are poor, and it has been recognised that some global estimates are significantly inflated. Here we assemble a large variety of available datasets and prioritise official data and emission factors, including estimates submitted to the UNFCCC plus new estimates for China and India, to present a new analysis of global process emissions from cement production. We show that global process emissions in 2016 were 1.45±0.20 Gt CO2, equivalent to about 4 % of emissions from fossil fuels. Cumulative emissions from 1928 to 2016 were 39.3±2.4 Gt CO2, 66 % of which have occurred since 1990. Emissions in 2015 were 30 % lower than those recently reported by the Global Carbon Project. The data associated with this article can be found at https://doi.org/10.5281/zenodo.831455.

  10. Global carbon stocks and potential emissions due to mangrove deforestation from 2000 to 2012

    NASA Astrophysics Data System (ADS)

    Hamilton, Stuart E.; Friess, Daniel A.

    2018-03-01

    Mangrove forests store high densities of organic carbon, which, when coupled with high rates of deforestation, means that mangroves have the potential to contribute substantially to carbon emissions. Consequently, mangroves are strong candidates for inclusion in nationally determined contributions (NDCs) to the United Nations Framework Convention on Climate Change (UNFCCC), and payments for ecosystem services (PES) programmes that financially incentivize the conservation of forested carbon stocks. This study quantifies annual mangrove carbon stocks from 2000 to 2012 at the global, national and sub-national levels, and global carbon emissions resulting from deforestation over the same time period. Globally, mangroves stored 4.19 Pg of carbon in 2012, with Indonesia, Brazil, Malaysia and Papua New Guinea accounting for more than 50% of the global stock. 2.96 Pg of the global carbon stock is contained within the soil and 1.23 Pg in the living biomass. Two percent of global mangrove carbon was lost between 2000 and 2012, equivalent to a maximum potential of 316,996,250 t of CO2 emissions.

  11. Constraining the physical state by symmetries

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Fatibene, L., E-mail: lorenzo.fatibene@unito.it; INFN - Sezione Torino - IS QGSKY; Ferraris, M.

    After reviewing the hole argument and its relations with initial value problem and general covariance, we shall discuss how much freedom one has to define the physical state in a generally covariant field theory (with or without internal gauge symmetries). Our analysis relies on Cauchy problems, thus it is restricted to globally hyperbolic spacetimes. We shall show that in generally covariant theories on a compact space (as well as for internal gauge symmetries on any spacetime) one has no freedom and one is forced to declare as physically equivalent two configurations which differ by a global spacetime diffeomorphism (or bymore » an internal gauge transformation) as it is usually prescribed. On the contrary, when space is not compact, the result does not hold true and one may have different options to define physically equivalent configurations, still preserving determinism. - Highlights: • Investigate the relation between the hole argument, covariance, determinism and physical state. • Show that if space is compact then any diffeomorphism is a gauge symmetry. • Show that if space is not compact then there may be more freedom in choosing gauge group.« less

  12. Evidence of a global magma ocean in Io's interior.

    PubMed

    Khurana, Krishan K; Jia, Xianzhe; Kivelson, Margaret G; Nimmo, Francis; Schubert, Gerald; Russell, Christopher T

    2011-06-03

    Extensive volcanism and high-temperature lavas hint at a global magma reservoir in Io, but no direct evidence has been available. We exploited Jupiter's rotating magnetic field as a sounding signal and show that the magnetometer data collected by the Galileo spacecraft near Io provide evidence of electromagnetic induction from a global conducting layer. We demonstrate that a completely solid mantle provides insufficient response to explain the magnetometer observations, but a global subsurface magma layer with a thickness of over 50 kilometers and a rock melt fraction of 20% or more is fully consistent with the observations. We also place a stronger upper limit of about 110 nanoteslas (surface equatorial field) on the dynamo dipolar field generated inside Io.

  13. Global public goods and health: taking the agenda forward.

    PubMed Central

    Kaul, I.; Faust, M.

    2001-01-01

    We examined recent special health initiatives to control HIV/AIDS, malaria, and tuberculosis, and make four policy recommendations for improving the sustainability of such initiatives. First, international cooperation on health should be seen as an issue of global public goods that concerns both poor and rich countries. Second, national health and other sector budgets should be tapped to ensure that global health concerns are fully and reliably funded; industrialized countries should lead the way. Third, a global research council should be established to foster more efficient health-related knowledge management. Fourth, managers for specific disease issues should be appointed, to facilitate policy partnerships. Policy changes in these areas have already begun and can provide a basis for further reform. PMID:11584736

  14. Antarctica, Greenland and Gulf of Alaska Land-ice Evolution from an Iterated GRACE Global Mascon Solution

    NASA Technical Reports Server (NTRS)

    Luthcke, Scott B.; Sabaka, T. J.; Loomis, B. D.; Arendt, A. A.; McCarthy, J. J.; Camp, J.

    2013-01-01

    We have determined the ice mass evolution of the Antarctica and Greenland ice sheets (AIS and GIS) and Gulf of Alaska (GOA) glaciers from a new GRACE global solution of equal-area surface mass concentration parcels (mascons) in equivalent height of water. The mascons were estimated directly from the reduction of the inter-satellite K-band range-rate (KBRR) observations, taking into account the full noise covariance, and formally iterating the solution. The new solution increases signal recovery while reducing the GRACE KBRR observation residuals. The mascons were estimated with 10 day and 1 arc degree equal-area sampling, applying anisotropic constraints. An ensemble empirical mode decomposition adaptive filter was applied to the mascon time series to compute annual mass balances. The details and causes of the spatial and temporal variability of the land-ice regions studied are discussed. The estimated mass trend over the total GIS, AIS and GOA glaciers for the time period 1 December 2003 to 1 December 2010 is -380 plus or minus 31 Gt a(exp -1), equivalent to -1.05 plus or minus 0.09 mma(exp -1) sea-level rise. Over the same time period we estimate the mass acceleration to be -41 plus or minus 27 Gt a(exp -2), equivalent to a 0.11 plus or minus 0.08 mm a(exp -2) rate of change in sea level. The trends and accelerations are dependent on significant seasonal and annual balance anomalies.

  15. Antarctica, Greenland and Gulf of Alaska Land-Ice Evolution from an Iterated GRACE Global Mascon Solution

    NASA Technical Reports Server (NTRS)

    Luthcke, Scott B.; Sabaka, T. J.; Loomis, B. D.; Arendt, A. A.; McCarthy, J. J.; Camp, J.

    2013-01-01

    We have determined the ice mass evolution of the Antarctica and Greenland ice sheets (AIS and GIS) and Gulf of Alaska (GOA) glaciers from a new GRACE global solution of equal-area surface mass concentration parcels (mascons) in equivalent height of water. The mascons were estimated directly from the reduction of the inter-satellite K-band range-rate (KBRR) observations, taking into account the full noise covariance, and formally iterating the solution. The new solution increases signal recovery while reducing the GRACE KBRR observation residuals. The mascons were estimated with 10 day and 1 arc degree equal-area sampling, applying anisotropic constraints. An ensemble empirical mode decomposition adaptive filter was applied to the mascon time series to compute annual mass balances. The details and causes of the spatial and temporal variability of the land-ice regions studied are discussed. The estimated mass trend over the total GIS, AIS and GOA glaciers for the time period 1 December 2003 to 1 December 2010 is -380 plus or minus 31 Gt a(exp -1), equivalent to -1.05 plus or minus 0.09 mma(exp -1) sea-level rise. Over the same time period we estimate the mass acceleration to be -41 plus or minus 27 Gt a(exp -2), equivalent to a 0.11 plus or minus 0.08 mm a(exp -2) rate of change in sea level. The trends and accelerations are dependent on significant seasonal and annual balance anomalies.

  16. A Coulomb-Like Off-Shell T-Matrix with the Correct Coulomb Phase Shift

    NASA Astrophysics Data System (ADS)

    Oryu, Shinsho; Watanabe, Takashi; Hiratsuka, Yasuhisa; Togawa, Yoshio

    2017-03-01

    We confirm the reliability of the well-known Coulomb renormalization method (CRM). It is found that the CRM is only available for a very-long-range screened Coulomb potential (SCP). However, such an SCP calculation in momentum space is considerably difficult because of the cancelation of significant digits. In contrast to the CRM, we propose a new method by using an on-shell equivalent SCP and the rest term. The two-potential theory with r-space is introduced, which defines fully the off-shell Coulomb amplitude.

  17. A Novel Solid State Ultracapacitor

    NASA Technical Reports Server (NTRS)

    Cortes-Pena, A. Y.; Rolin, T. D.; Hill, C. W.

    2017-01-01

    Novel dielectric materials were researched to develop an internal barrier layer capacitor that is fully solid state. These materials included reduced nanoparticles of barium titanate that were coated with various atomic layer deposited oxides. The nanoparticle powders were then densified into pellets and characterized using a dielectric test fixture over a frequency range of 20 Hz to 2 MHz. Densification and sintering were evaluated using scanning electron microscopic techniques. Ultimately, the samples showing the most promising electrical characteristics of permittivity, dissipation factor and equivalent series resistance were chosen to manufacture devices for subsequent testing.

  18. Application of Rapid Solidification Techniques to Aluminum Alloys

    DTIC Science & Technology

    1980-10-01

    relatkonship h e 4r eoTs/(T5 TG) (3.7) 32 where e is the surface emissivity, a is the Stefan Boltzmann constant, Ts and TG are the droplet and cooling...their fully implicit form and solved by a Gauss Seidel iteration routine. The results are I I 40I compared with the equivalent Newtonian case and...temperature respectively, Fo is the Fourier number or dimensionless time, Fo = aLt/r2 (5.2) and Ste is the Stefan number, Ste = CL (TM - TG)/AHM (5.3) which

  19. A variable resolution nonhydrostatic global atmospheric semi-implicit semi-Lagrangian model

    NASA Astrophysics Data System (ADS)

    Pouliot, George Antoine

    2000-10-01

    The objective of this project is to develop a variable-resolution finite difference adiabatic global nonhydrostatic semi-implicit semi-Lagrangian (SISL) model based on the fully compressible nonhydrostatic atmospheric equations. To achieve this goal, a three-dimensional variable resolution dynamical core was developed and tested. The main characteristics of the dynamical core can be summarized as follows: Spherical coordinates were used in a global domain. A hydrostatic/nonhydrostatic switch was incorporated into the dynamical equations to use the fully compressible atmospheric equations. A generalized horizontal variable resolution grid was developed and incorporated into the model. For a variable resolution grid, in contrast to a uniform resolution grid, the order of accuracy of finite difference approximations is formally lost but remains close to the order of accuracy associated with the uniform resolution grid provided the grid stretching is not too significant. The SISL numerical scheme was implemented for the fully compressible set of equations. In addition, the generalized minimum residual (GMRES) method with restart and preconditioner was used to solve the three-dimensional elliptic equation derived from the discretized system of equations. The three-dimensional momentum equation was integrated in vector-form to incorporate the metric terms in the calculations of the trajectories. Using global re-analysis data for a specific test case, the model was compared to similar SISL models previously developed. Reasonable agreement between the model and the other independently developed models was obtained. The Held-Suarez test for dynamical cores was used for a long integration and the model was successfully integrated for up to 1200 days. Idealized topography was used to test the variable resolution component of the model. Nonhydrostatic effects were simulated at grid spacings of 400 meters with idealized topography and uniform flow. Using a high-resolution topographic data set and the variable resolution grid, sets of experiments with increasing resolution were performed over specific regions of interest. Using realistic initial conditions derived from re-analysis fields, nonhydrostatic effects were significant for grid spacings on the order of 0.1 degrees with orographic forcing. If the model code was adapted for use in a message passing interface (MPI) on a parallel supercomputer today, it was estimated that a global grid spacing of 0.1 degrees would be achievable for a global model. In this case, nonhydrostatic effects would be significant for most areas. A variable resolution grid in a global model provides a unified and flexible approach to many climate and numerical weather prediction problems. The ability to configure the model from very fine to very coarse resolutions allows for the simulation of atmospheric phenomena at different scales using the same code. We have developed a dynamical core illustrating the feasibility of using a variable resolution in a global model.

  20. Complex dynamics of a new 3D Lorenz-type autonomous chaotic system

    NASA Astrophysics Data System (ADS)

    Zhang, Fuchen; Liao, Xiaofeng; Zhang, Guangyun; Mu, Chunlai

    2017-12-01

    This paper investigates a new three-dimensional continuous quadratic autonomous chaotic system which is not topologically equivalent to the Lorenz system. The dynamical behaviours of this system are further investigated in detail, including the ultimate boundedness, the invariant sets and the global attraction domain according to Lyapunov stability theory of dynamical systems. The innovation of the paper lies in the fact that this paper not only proves this chaotic system is globally bounded for the parameters of this system but also gives a family of mathematical expressions of global exponential attractive sets with respect to the parameters of this system. To validate the ultimate bound estimation, numerical simulations are also investigated. Numerical simulations verify the effectiveness and feasibility of the theoretical scheme.

  1. The impact of agricultural soil erosion on the global carbon cycle

    USGS Publications Warehouse

    Van Oost, Kristof; Quine, T.A.; Govers, G.; De Gryze, S.; Six, J.; Harden, J.W.; Ritchie, J.C.; McCarty, G.W.; Heckrath, G.; Kosmas, C.; Giraldez, J.V.; Marques Da Silva, J.R.; Merckx, R.

    2007-01-01

    Agricultural soil erosion is thought to perturb the global carbon cycle, but estimates of its effect range from a source of 1 petagram per year -1 to a sink of the same magnitude. By using caesium-137 and carbon inventory measurements from a large-scale survey, we found consistent evidence for an erosion-induced sink of atmospheric carbon equivalent to approximately 26% of the carbon transported by erosion. Based on this relationship, we estimated a global carbon sink of 0.12 (range 0.06 to 0.27) petagrams of carbon per year-1 resulting from erosion in the world's agricultural landscapes. Our analysis directly challenges the view that agricultural erosion represents an important source or sink for atmospheric CO2.

  2. Comparing the effects of kamikihito in Japan and kami-guibi-tang in Korea on memory enhancement: working towards the development of a global study.

    PubMed

    Watari, Hidetoshi; Shigyo, Michiko; Tanabe, Norio; Tohda, Michihisa; Cho, Ki-Ho; Kyung, Park Su; Jung, Woo Sang; Shimada, Yutaka; Shibahara, Naotoshi; Kuboyama, Tomoharu; Tohda, Chihiro

    2015-03-01

    Traditional medicine is widely used in East Asia, and studies that demonstrate its usefulness have recently become more common. However, formulation-based studies are not globally understood because these studies are country-specific. There are many types of formulations that have been introduced to Japan and Korea from China. Establishing whether a same-origin formulation has equivalent effects in other countries is important for the development of studies that span multiple countries. The present study compared the effects of same-origin traditional medicine used in Japan and Korea in an in vivo experiment. We prepared drugs that had the same origin and the same components. The drugs are called kamikihito (KKT) in Japan and kami-guibi-tang (KGT) in Korea. KKT (500 mg extract/kg/day) and KGT (500 mg extract/kg/day) were administered to ddY mice, and object recognition and location memory tests were performed. KKT and KGT administration yielded equivalent normal memory enhancement effects. 3D-HPLC showed similar, but not identical, patterns of the detected compounds between KKT and KGT. This comparative research approach enables future global clinical studies of traditional medicine to be conducted through the use of the formulations prescribed in each country. Copyright © 2014 John Wiley & Sons, Ltd.

  3. In situ imaging reveals the biomass of giant protists in the global ocean.

    PubMed

    Biard, Tristan; Stemmann, Lars; Picheral, Marc; Mayot, Nicolas; Vandromme, Pieter; Hauss, Helena; Gorsky, Gabriel; Guidi, Lionel; Kiko, Rainer; Not, Fabrice

    2016-04-28

    Planktonic organisms play crucial roles in oceanic food webs and global biogeochemical cycles. Most of our knowledge about the ecological impact of large zooplankton stems from research on abundant and robust crustaceans, and in particular copepods. A number of the other organisms that comprise planktonic communities are fragile, and therefore hard to sample and quantify, meaning that their abundances and effects on oceanic ecosystems are poorly understood. Here, using data from a worldwide in situ imaging survey of plankton larger than 600 μm, we show that a substantial part of the biomass of this size fraction consists of giant protists belonging to the Rhizaria, a super-group of mostly fragile unicellular marine organisms that includes the taxa Phaeodaria and Radiolaria (for example, orders Collodaria and Acantharia). Globally, we estimate that rhizarians in the top 200 m of world oceans represent a standing stock of 0.089 Pg carbon, equivalent to 5.2% of the total oceanic biota carbon reservoir. In the vast oligotrophic intertropical open oceans, rhizarian biomass is estimated to be equivalent to that of all other mesozooplankton (plankton in the size range 0.2-20 mm). The photosymbiotic association of many rhizarians with microalgae may be an important factor in explaining their distribution. The previously overlooked importance of these giant protists across the widest ecosystem on the planet changes our understanding of marine planktonic ecosystems.

  4. Current and Future Greenhouse Gas Emissions from Global Crop Intensification and Expansion

    NASA Astrophysics Data System (ADS)

    Carlson, K. M.; Gerber, J. S.; Mueller, N. D.; O'Connell, C.; West, P. C.

    2014-12-01

    Food systems currently contribute up to one-third of total anthropogenic greenhouse gas emissions, and these emissions are expected to rise as demand for agricultural products increases. Thus, improving the greenhouse gas emissions efficiency of agriculture - the tons or kilocalories of production per ton of CO2 equivalent emissions - will be critical to support a resilient future global system. Here, we model and evaluate global, 2000-era, spatially explicit relationships between a suite of greenhouse gas emissions from various agronomic practices (i.e., fertilizer application, peatland draining, and rice cultivation) and crop yields. Then, we predict potential emissions from future crop production increases achieved through intensification and extensification, including CO2 emissions from croplands replacing non-urban land cover. We find that 2000-era yield-scaled agronomic emissions are highly heterogeneous across crops types, crop management practices, and regions. Rice agriculture produces more total CO2-equivalent emissions than any other crop. Moreover, inundated rice in just a few countries contributes the vast majority of these rice emissions. Crops such as sunflower and cotton have low efficiency on a caloric basis. Our results suggest that intensification tends to be a more efficient pathway to boost greenhouse gas emissions efficiency than expansion. We conclude by discussing potential crop- and region-specific agricultural development pathways that may boost the greenhouse gas emissions efficiency of agriculture.

  5. The eHealth agenda for developing countries.

    PubMed

    Drury, Peter

    2005-01-01

    Delivering eHealth in developing countries faces different health and socio-economic challenges to the developed one. But, if a global health infrastructure is to evolve, then developing countries need to play their part. So, whilst the context may differ, the localization-globalization of content issues needs to be jointly addressed. In providing robust and affordable connectivity, particularly to rural areas, developing countries can fully exploit the potential of handheld computers and wireless connectivity. Over such an infrastructure new ways of building capacity, both locally and globally, can be supported. Finally, an eHealth infrastructure can support the delivery of healthcare in communities, thereby supporting individuals and community development.

  6. Salt Transport in the Near-Surface Layer in the Monsoon-Influenced Indian Ocean Using HYCOM

    DTIC Science & Technology

    2010-08-04

    A copy is filed in this office. Office of Counsel,Code 1008.3 ADOR/Director NCST E. R. Franchi , 7000 .^SLjdM/fc^- */?//<» Public Affairs...mechanisms for the transport of salt in the Indian Ocean are not fully understood. Global HYCOM simulated SSS data, validated with in situ observations...included in the HYCOM SSS simulations. 2. Data and Methods [6] This study uses the 4 year period (2003-2006) monthly SSS from the global HYbrid

  7. United States Policy in India: Balancing Global and Regional Perspectives.

    DTIC Science & Technology

    1983-12-01

    ability to contribute to the Soviet Union’s adoption of a prb-Indian position on the Kashmir dispute from Novembe;, 1955; ii| Moscow’s impact on India’s...policies of the current administration under President Reagan. The generally positive attitude. that the 4W Soviet Union has adopted towards Indian... impact of the actions on local opinion or they discounted it as unimportant in the global context. The United States did not become fully. involved in

  8. Evaluation, Language, and Untranslatables

    ERIC Educational Resources Information Center

    Dahler-Larsen, Peter; Abma, Tineke; Bustelo, María; Irimia, Roxana; Kosunen, Sonja; Kravchuk, Iryna; Minina, Elena; Segerholm, Christina; Shiroma, Eneida; Stame, Nicoletta; Tshali, Charlie Kabanga

    2017-01-01

    The issue of translatability is pressing in international evaluation, in global transfer of evaluative instruments, in comparative performance management, and in culturally responsive evaluation. Terms that are never fully understood, digested, or accepted may continue to influence issues, problems, and social interactions in and around and after…

  9. Quenched dynamics of classical isolated systems: the spherical spin model with two-body random interactions or the Neumann integrable model

    NASA Astrophysics Data System (ADS)

    Cugliandolo, Leticia F.; Lozano, Gustavo S.; Nessi, Nicolás; Picco, Marco; Tartaglia, Alessandro

    2018-06-01

    We study the Hamiltonian dynamics of the spherical spin model with fully-connected two-body random interactions. In the statistical physics framework, the potential energy is of the so-called p  =  2 kind, closely linked to the scalar field theory. Most importantly for our setting, the energy conserving dynamics are equivalent to the ones of the Neumann integrable model. We take initial conditions from the Boltzmann equilibrium measure at a temperature that can be above or below the static phase transition, typical of a disordered (paramagnetic) or of an ordered (disguised ferromagnetic) equilibrium phase. We subsequently evolve the configurations with Newton dynamics dictated by a different Hamiltonian, obtained from an instantaneous global rescaling of the elements in the interaction random matrix. In the limit of infinitely many degrees of freedom, , we identify three dynamical phases depending on the parameters that characterise the initial state and the final Hamiltonian. We next set the analysis of the system with finite number of degrees of freedom in terms of N non-linearly coupled modes. We argue that in the limit the modes decouple at long times. We evaluate the mode temperatures and we relate them to the frequency-dependent effective temperature measured with the fluctuation-dissipation relation in the frequency domain, similarly to what was recently proposed for quantum integrable cases. Finally, we analyse the N  ‑  1 integrals of motion, notably, their scaling with N, and we use them to show that the system is out of equilibrium in all phases, even for parameters that show an apparent Gibbs–Boltzmann behaviour of the global observables. We elaborate on the role played by these constants of motion after the quench and we briefly discuss the possible description of the asymptotic dynamics in terms of a generalised Gibbs ensemble.

  10. Cross-cultural adaptation of the Schizophrenia Caregiver Questionnaire (SCQ) and the Caregiver Global Impression (CaGI) Scales in 11 languages.

    PubMed

    Rofail, Diana; Acquadro, Catherine; Izquierdo, Cécile; Regnault, Antoine; Zarit, Steven H

    2015-06-09

    The Schizophrenia Caregiver Questionnaire (SCQ) was developed to provide a comprehensive view of caregivers' subjective experiences of the impacts of caring for someone with schizophrenia. The Caregiver Global Impression (CaGI) scales were designed to assess their perception of the severity of the schizophrenia symptoms, of change in schizophrenia symptoms and in the experience of caring since the beginning of the study. The objectives of the study were to translate the SCQ and CaGI scales in 11 languages [French (Canada, France), English (Canada, UK, Australia), German (Germany), Italian (Italy), Spanish (Spain), Dutch (the Netherlands), Finnish (Finland), and Swedish (Sweden)], to present evidence that the translations capture the concepts of the original questionnaires and are well understood by caregivers of patients with schizophrenia in each target country. The different language versions were developed using a standard or adjusted linguistic validation process fully complying with the International Society for Pharmacoeconomics and Outcomes Research (ISPOR) recommended procedures. Interviews were conducted with 55 caregivers of patients with schizophrenia from 10 countries representing the 11 different languages. Participants ranged in age from 28 to 84 years and had 5 to 16 years of education. Women represented 69.1 % (38/55) of the sample. Fourteen out of the 32 items of the SCQ generated difficulties which were mostly of semantic origin (13 items). The translation of the CaGI scales did not raise any major difficulty. Only five out of the 55 caregivers had difficulty understanding the meaning of the translations of "degree" in the expressions "degree of change in experience of caring" and "degree of change in symptoms". Translations of the SCQ and CaGI scales into 11 languages adequately captured the concepts in the original English versions of the questionnaires, thereby demonstrating the conceptual, semantic, and cultural equivalence of each translation.

  11. Identification of adverse events that have a negative impact on quality of life in a clinical trial comparing docetaxel versus S-1 with cisplatin in lung cancer.

    PubMed

    Aotani, Eriko; Hamano, Tetsutaro; Gemma, Akihiko; Takeuchi, Masahiro; Takebayashi, Toru; Kobayashi, Kunihiko

    2016-10-01

    In the CATS (Cisplatin And TS-1) randomized trial comparing cisplatin plus either docetaxel (DP arm) or TS-1 (SP arm) in lung cancer, efficacy was found to be equivalent but the global quality of life (QOL) score was higher in the SP arm. The purpose of the current study was to identify which of the adverse events (AEs) contributed to the deterioration of QOL. QOL and AE data from the CATS trial were used to quantitatively analyze the relationship between deterioration of QOL score and occurrence of AEs. Subtracted values of the QOL score from post-chemotherapy to pre-chemotherapy were fully compared between patients with or without each AE (Student's t test, significance level = 0.001). Multivariate linear regression analysis was also performed. Analysis of variance was performed to identify whether grade of AE(s) might be significantly correlated with the deterioration of the QOL score (significance level of 0.05). As expected, gastrointestinal (GI) toxicities were associated with worsening of a variety of QOL items in both trial arms, detected by both univariate and multivariate analysis (p < 0.001 and p < 0.0001, respectively). Multivariate analysis unpredictably indicated that an increase in serum bilirubin level was the only AE that was uniquely associated with worsening of physical functioning (p = 0.0002), cognitive functioning (p < 0.0001), and financial problems (p = 0.0005) in the DP arm, although not in the SP arm. GI toxicities tended to be prolonged in the SP arm. An increase in serum bilirubin level may contribute to the worse global QOL of subjects in the DP arm in the CATS trial. The method we used here may be a unique approach to identify unpredictable AE(s) that worsen the QOL of patients treated by chemotherapy.

  12. Evolution and polymorphism in the multilocus Levene model with no or weak epistasis.

    PubMed

    Bürger, Reinhard

    2010-09-01

    Evolution and the maintenance of polymorphism under the multilocus Levene model with soft selection are studied. The number of loci and alleles, the number of demes, the linkage map, and the degree of dominance are arbitrary, but epistasis is absent or weak. We prove that, without epistasis and under mild, generic conditions, every trajectory converges to a stationary point in linkage equilibrium. Consequently, the equilibrium and stability structure can be determined by investigating the much simpler gene-frequency dynamics on the linkage-equilibrium manifold. For a haploid species an analogous result is shown. For weak epistasis, global convergence to quasi-linkage equilibrium is established. As an application, the maintenance of multilocus polymorphism is explored if the degree of dominance is intermediate at every locus and epistasis is absent or weak. If there are at least two demes, then arbitrarily many multiallelic loci can be maintained polymorphic at a globally asymptotically stable equilibrium. Because this holds for an open set of parameters, such equilibria are structurally stable. If the degree of dominance is not only intermediate but also deme independent, and loci are diallelic, an open set of parameters yielding an internal equilibrium exists only if the number of loci is strictly less than the number of demes. Otherwise, a fully polymorphic equilibrium exists only nongenerically, and if it exists, it consists of a manifold of equilibria. Its dimension is determined. In the absence of genotype-by-environment interaction, however, a manifold of equilibria occurs for an open set of parameters. In this case, the equilibrium structure is not robust to small deviations from no genotype-by-environment interaction. In a quantitative-genetic setting, the assumptions of no epistasis and intermediate dominance are equivalent to assuming that in every deme directional selection acts on a trait that is determined additively, i.e., by nonepistatic loci with dominance. Some of our results are exemplified in this quantitative-genetic context. Copyright 2010 Elsevier Inc. All rights reserved.

  13. Connected Component Model for Multi-Object Tracking.

    PubMed

    He, Zhenyu; Li, Xin; You, Xinge; Tao, Dacheng; Tang, Yuan Yan

    2016-08-01

    In multi-object tracking, it is critical to explore the data associations by exploiting the temporal information from a sequence of frames rather than the information from the adjacent two frames. Since straightforwardly obtaining data associations from multi-frames is an NP-hard multi-dimensional assignment (MDA) problem, most existing methods solve this MDA problem by either developing complicated approximate algorithms, or simplifying MDA as a 2D assignment problem based upon the information extracted only from adjacent frames. In this paper, we show that the relation between associations of two observations is the equivalence relation in the data association problem, based on the spatial-temporal constraint that the trajectories of different objects must be disjoint. Therefore, the MDA problem can be equivalently divided into independent subproblems by equivalence partitioning. In contrast to existing works for solving the MDA problem, we develop a connected component model (CCM) by exploiting the constraints of the data association and the equivalence relation on the constraints. Based upon CCM, we can efficiently obtain the global solution of the MDA problem for multi-object tracking by optimizing a sequence of independent data association subproblems. Experiments on challenging public data sets demonstrate that our algorithm outperforms the state-of-the-art approaches.

  14. Equivalent Sensor Radiance Generation and Remote Sensing from Model Parameters. Part 1; Equivalent Sensor Radiance Formulation

    NASA Technical Reports Server (NTRS)

    Wind, Galina; DaSilva, Arlindo M.; Norris, Peter M.; Platnick, Steven E.

    2013-01-01

    In this paper we describe a general procedure for calculating equivalent sensor radiances from variables output from a global atmospheric forecast model. In order to take proper account of the discrepancies between model resolution and sensor footprint the algorithm takes explicit account of the model subgrid variability, in particular its description of the probably density function of total water (vapor and cloud condensate.) The equivalent sensor radiances are then substituted into an operational remote sensing algorithm processing chain to produce a variety of remote sensing products that would normally be produced from actual sensor output. This output can then be used for a wide variety of purposes such as model parameter verification, remote sensing algorithm validation, testing of new retrieval methods and future sensor studies. We show a specific implementation using the GEOS-5 model, the MODIS instrument and the MODIS Adaptive Processing System (MODAPS) Data Collection 5.1 operational remote sensing cloud algorithm processing chain (including the cloud mask, cloud top properties and cloud optical and microphysical properties products.) We focus on clouds and cloud/aerosol interactions, because they are very important to model development and improvement.

  15. A novel automated direct measurement method for total antioxidant capacity using a new generation, more stable ABTS radical cation.

    PubMed

    Erel, Ozcan

    2004-04-01

    To develop a novel colorimetric and automated direct measurement method for total antioxidant capacity (TAC). A new generation, more stable, colored 2,2'-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid radical cation (ABTS(*+)) was employed. The ABTS(*+) is decolorized by antioxidants according to their concentrations and antioxidant capacities. This change in color is measured as a change in absorbance at 660 nm. This process is applied to an automated analyzer and the assay is calibrated with Trolox. The novel assay is linear up to 6 mmol Trolox equivalent/l, its precision values are lower than 3%, and there is no interference from hemoglobin, bilirubin, EDTA, or citrate. The method developed is significantly correlated with the Randox- total antioxidant status (TAS) assay (r = 0.897, P < 0.0001; n = 91) and with the ferric reducing ability of plasma (FRAP) assay (r = 0.863, P < 0.0001; n = 110). Serum TAC level was lower in patients with major depression (1.69 +/- 0.11 mmol Trolox equivalent/l) than in healthy subjects (1.75 +/- 0.08 mmol Trolox equivalent/l, P = 0.041). This easy, stable, reliable, sensitive, inexpensive, and fully automated method described can be used to measure total antioxidant capacity.

  16. An empirical assessment of taxic paleobiology.

    PubMed

    Adrain, J M; Westrop, S R

    2000-07-07

    The analysis of major changes in faunal diversity through time is a central theme of analytical paleobiology. The most important sources of data are literature-based compilations of stratigraphic ranges of fossil taxa. The levels of error in these compilations and the possible effects of such error have often been discussed but never directly assessed. We compared our comprehensive database of trilobites to the equivalent portion of J. J. Sepkoski Jr.'s widely used global genus database. More than 70% of entries in the global database are inaccurate; however, as predicted, the error is randomly distributed and does not introduce bias.

  17. Neutrino Masses in the Landscape and Global-Local Dualities in Eternal Inflation

    NASA Astrophysics Data System (ADS)

    Mainemer Katz, Dan

    In this dissertation we study two topics in Theoretical Cosmology: one more formal, the other more phenomenological. We work in the context of eternally inflating cosmologies. These arise in any fundamental theory that contains at least one stable or metastable de Sitter vacuum. Each topic is presented in a different chapter: Chapter 1 deals with the measure problem in eternal inflation. Global-local duality is the equivalence of seemingly different regulators in eternal inflation. For example, the light- cone time cutoff (a global measure, which regulates time) makes the same predictions as the causal patch (a local measure that cuts off space). We show that global-local duality is far more general. It rests on a redundancy inherent in any global cutoff: at late times, an attractor regime is reached, characterized by the unlimited exponential self-reproduction of a certain fundamental region of spacetime. An equivalent local cutoff can be obtained by restricting to this fundamental region. We derive local duals to several global cutoffs of interest. The New Scale Factor Cutoff is dual to the Short Fat Geodesic, a geodesic of fixed infinitesimal proper width. Vilenkin's CAH Cutoff is equivalent to the Hubbletube, whose width is proportional to the local Hubble volume. The famous youngness problem of the Proper Time Cutoff can be readily understood by considering its local dual, the Incredible Shrinking Geodesic. The chapter closely follows our paper. Chapter 2 deals with the question of whether neutrino masses could be anthropically explained. The sum of active neutrino masses is well constrained, 58 meV ≤ mupsilon [is approximately less than] 0.23 eV, but the origin of this scale is not well understood. Here we investigate the possibility that it arises by environmental selection in a large landscape of vacua. Earlier work had noted the detrimental effects of neutrinos on large scale structure. However, using Boltzmann codes to compute the smoothed density contrast on Mpc scales, we find that dark matter halos form abundantly for mupsilon [is approximately greater than] 10eV. This finding rules out an anthropic origin of mupsilon, unless a different catastrophic boundary can be identified. Here we argue that galaxy formation becomes inefficient for mupsilon [is approximately greater than] 10 eV. We show that in this regime, structure forms late and is dominated by cluster scales, as in a top-down scenario. This is catastrophic: baryonic gas will cool too slowly to form stars in an abundance comparable to our universe. With this novel cooling boundary, we find that the anthropic prediction for mupsilon agrees at better than 2sigma with current observational bounds. A degenerate hierarchy is mildly preferred. The chapter closely follows our paper.

  18. Formation and Reconnection of Three-Dimensional Current Sheets in the Solar Corona

    NASA Technical Reports Server (NTRS)

    Edmondson, J. K.; Antiochos, S. K.; DeVore, C. R.; Zurbuchen, T. H.

    2010-01-01

    Current-sheet formation and magnetic reconnection are believed to be the basic physical processes responsible for much of the activity observed in astrophysical plasmas, such as the Sun s corona. We investigate these processes for a magnetic configuration consisting of a uniform background field and an embedded line dipole, a topology that is expected to be ubiquitous in the corona. This magnetic system is driven by a uniform horizontal flow applied at the line-tied photosphere. Although both the initial field and the driver are translationally symmetric, the resulting evolution is calculated using a fully three-dimensional magnetohydrodynamic (3D MHD) simulation with adaptive mesh refinement that resolves the current sheet and reconnection dynamics in detail. The advantage of our approach is that it allows us to apply directly the vast body of knowledge gained from the many studies of 2D reconnection to the fully 3D case. We find that a current sheet forms in close analogy to the classic Syrovatskii 2D mechanism, but the resulting evolution is different than expected. The current sheet is globally stable, showing no evidence for a disruption or a secondary instability even for aspect ratios as high as 80:1. The global evolution generally follows the standard Sweet- Parker 2D reconnection model except for an accelerated reconnection rate at a very thin current sheet, due to the tearing instability and the formation of magnetic islands. An interesting conclusion is that despite the formation of fully 3D structures at small scales, the system remains close to 2D at global scales. We discuss the implications of our results for observations of the solar corona. Subject Headings: Sun: corona Sun: magnetic fields Sun: reconnection

  19. Fugitive Emissions from the Bakken Shale Illustrate Role of Shale Production in Global Ethane Shift

    NASA Technical Reports Server (NTRS)

    Kort, E. A.; Smith, M. L.; Murray, L. T.; Gvakharia, A.; Brandt, A. R.; Peischl, J.; Ryerson, T. B.; Sweeney, C.; Travis, K.

    2016-01-01

    Ethane is the second most abundant atmospheric hydrocarbon, exerts a strong influence on tropospheric ozone, and reduces the atmosphere's oxidative capacity. Global observations showed declining ethane abundances from 1984 to 2010, while a regional measurement indicated increasing levels since 2009, with the reason for this subject to speculation. The Bakken shale is an oil and gas-producing formation centered in North Dakota that experienced a rapid increase in production beginning in 2010. We use airborne data collected over the North Dakota portion of the Bakken shale in 2014 to calculate ethane emissions of 0.23 +/- 0.07 (2 sigma) Tg/yr, equivalent to 1-3% of total global sources. Emissions of this magnitude impact air quality via concurrent increases in tropospheric ozone. This recently developed large ethane source from one location illustrates the key role of shale oil and gas production in rising global ethane levels.

  20. Key global environmental impacts of genetically modified (GM) crop use 1996–2012

    PubMed Central

    Barfoot, Peter; Brookes, Graham

    2014-01-01

    Against the background of increasing awareness and appreciation of issues such as global warming and the impact of mankind’s activities such as agriculture on the global environment, this paper updates previous assessments of some key environmental impacts that crop biotechnology has had on global agriculture. It focuses on the environmental impacts associated with changes in pesticide use and greenhouse gas emissions arising from the use of GM crops. The adoption of the technology has reduced pesticide spraying by 503 million kg (-8.8%) and, as a result, decreased the environmental impact associated with herbicide and insecticide use on these crops (as measured by the indicator the Environmental Impact Quotient [EIQ]) by 18.7%. The technology has also facilitated a significant reduction in the release of greenhouse gas emissions from this cropping area, which, in 2012, was equivalent to removing 11.88 million cars from the roads. PMID:24637726

  1. Fuel use and greenhouse gas emissions of world fisheries

    NASA Astrophysics Data System (ADS)

    Parker, Robert W. R.; Blanchard, Julia L.; Gardner, Caleb; Green, Bridget S.; Hartmann, Klaas; Tyedmers, Peter H.; Watson, Reg A.

    2018-04-01

    Food production is responsible for a quarter of anthropogenic greenhouse gas (GHG) emissions globally. Marine fisheries are typically excluded from global assessments of GHGs or are generalized based on a limited number of case studies. Here we quantify fuel inputs and GHG emissions for the global fishing fleet from 1990-2011 and compare emissions from fisheries to those from agriculture and livestock production. We estimate that fisheries consumed 40 billion litres of fuel in 2011 and generated a total of 179 million tonnes of CO2-equivalent GHGs (4% of global food production). Emissions from the global fishing industry grew by 28% between 1990 and 2011, with little coinciding increase in production (average emissions per tonne landed grew by 21%). Growth in emissions was driven primarily by increased harvests from fuel-intensive crustacean fisheries. The environmental benefit of low-carbon fisheries could be further realized if a greater proportion of landings were directed to human consumption rather than industrial uses.

  2. Modern inhalation anesthetics: Potent greenhouse gases in the global atmosphere

    NASA Astrophysics Data System (ADS)

    Vollmer, Martin K.; Rhee, Tae Siek; Rigby, Matt; Hofstetter, Doris; Hill, Matthias; Schoenenberger, Fabian; Reimann, Stefan

    2015-03-01

    Modern halogenated inhalation anesthetics undergo little metabolization during clinical application and evaporate almost completely to the atmosphere. Based on their first measurements in a range of environments, from urban areas to the pristine Antarctic environment, we detect a rapid accumulation and ubiquitous presence of isoflurane, desflurane, and sevoflurane in the global atmosphere. Over the past decade, their abundances in the atmosphere have increased to global mean mole fractions in 2014 of 0.097ppt, 0.30ppt, and 0.13ppt (parts per trillion, 10-12, in dry air), respectively. Emissions of these long-lived greenhouse gases inferred from the observations suggest a global combined release to the atmosphere of 3.1 ± 0.6 million t CO2 equivalent in 2014 of which ≈80% stems from desflurane. We also report on halothane, a previously widely used anesthetic. Its global mean mole fraction has declined to 9.2ppq (parts per quadrillion, 10-15) by 2014. However, the inferred present usage is still 280 ±120t yr-1.

  3. Weighted interior penalty discretization of fully nonlinear and weakly dispersive free surface shallow water flows

    NASA Astrophysics Data System (ADS)

    Di Pietro, Daniele A.; Marche, Fabien

    2018-02-01

    In this paper, we further investigate the use of a fully discontinuous Finite Element discrete formulation for the study of shallow water free surface flows in the fully nonlinear and weakly dispersive flow regime. We consider a decoupling strategy in which we approximate the solutions of the classical shallow water equations supplemented with a source term globally accounting for the non-hydrostatic effects. This source term can be computed through the resolution of elliptic second-order linear sub-problems, which only involve second order partial derivatives in space. We then introduce an associated Symmetric Weighted Internal Penalty discrete bilinear form, allowing to deal with the discontinuous nature of the elliptic problem's coefficients in a stable and consistent way. Similar discrete formulations are also introduced for several recent optimized fully nonlinear and weakly dispersive models. These formulations are validated again several benchmarks involving h-convergence, p-convergence and comparisons with experimental data, showing optimal convergence properties.

  4. Tests of gravity with future space-based experiments

    NASA Astrophysics Data System (ADS)

    Sakstein, Jeremy

    2018-03-01

    Future space-based tests of relativistic gravitation—laser ranging to Phobos, accelerometers in orbit, and optical networks surrounding Earth—will constrain the theory of gravity with unprecedented precision by testing the inverse-square law, the strong and weak equivalence principles, and the deflection and time delay of light by massive bodies. In this paper, we estimate the bounds that could be obtained on alternative gravity theories that use screening mechanisms to suppress deviations from general relativity in the Solar System: chameleon, symmetron, and Galileon models. We find that space-based tests of the parametrized post-Newtonian parameter γ will constrain chameleon and symmetron theories to new levels, and that tests of the inverse-square law using laser ranging to Phobos will provide the most stringent constraints on Galileon theories to date. We end by discussing the potential for constraining these theories using upcoming tests of the weak equivalence principle, and conclude that further theoretical modeling is required in order to fully utilize the data.

  5. Application of photon Doppler velocimetry to direct impact Hopkinson pressure bars

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Lea, Lewis J., E-mail: ll379@cam.ac.uk; Jardine, Andrew P.

    2016-02-15

    Direct impact Hopkinson pressure bar systems offer many potential advantages over split Hopkinson pressure bars, including access to higher strain rates, higher strains for equivalent striker velocity and system length, lower dispersion, and faster achievement of force equilibrium. Currently, these advantages are gained at the expense of all information about the striker impacted specimen face, preventing the experimental determination of force equilibrium, and requiring approximations to be made on the sample deformation history. In this paper, we discuss an experimental method and complementary data analysis for using photon Doppler velocimetry to measure surface velocities of the striker and output barsmore » in a direct impact bar experiment, allowing similar data to be recorded as in a split bar system. We discuss extracting velocity and force measurements, and the precision of measurements. Results obtained using the technique are compared to equivalent split bar tests, showing improved stress measurements for the lowest and highest strains in fully dense metals, and improvement for all strains in slow and non-equilibrating materials.« less

  6. 77 FR 70440 - Hertz Global Holdings, Inc.; Analysis of Agreement Containing Consent Orders To Aid Public Comment

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-26

    ... state identification number or foreign country equivalent, passport number, financial account number, or... information. In addition, do not include any ``[t]rade secret or any commercial or financial information which... convenience, autonomy, or cost efficiency of renting a car, and, as a practical matter, customers are unlikely...

  7. Teaching International Business across Multiple Modes of Delivery: How to Maintain Equivalence in Learning Outcomes

    ERIC Educational Resources Information Center

    Drew, Antony

    2014-01-01

    The drivers of globalization are changing how, where, and when international business (IB) is being taught, and increasing student diversity. Concomitantly, education is becoming an important contributor to GDP in developed economies. Today, the same course may be taught at home to domestic and in-bound international students, in host countries,…

  8. English-Portuguese Equivalents of Forestry and Conservation Terms

    Treesearch

    John K. Francis

    1994-01-01

    Signs of deterioration of the global environment and threatened destruction of the vast Amazon forest have stirred a call for action.Conservationists have always been concerned about the tropical forests; now funds are being made available for increased work on problems in the region. Brazilian scientists struggle to communicate with colleagues in the rest of the world...

  9. Developing and Testing a Measure of Social Support with Mexican-Origin Pregnant Adolescents and Their Mother Figures

    ERIC Educational Resources Information Center

    Umana-Taylor, Adriana J.; Updegraff, Kimberly A.; White, Rebecca M. B.; Herzog, Melissa J.; Pflieger, Jacqueline C.; Madden-Derdich, Debra

    2011-01-01

    The current study describes the development and psychometric testing of the Global Support From Mother Figure During Pregnancy Scale (GSMF-P). The measure is developed in both Spanish and English to assess social support provided to adolescents during their pregnancies. The current study examines the reliability, cross-language equivalence, and…

  10. Complete Genome Sequences of Four Isolates of Plutella xylostella Granulovirus.

    PubMed

    Spence, Robert J; Noune, Christopher; Hauxwell, Caroline

    2016-06-30

    Granuloviruses are widespread pathogens of Plutella xylostella L. (diamondback moth) and potential biopesticides for control of this global insect pest. We report the complete genomes of four Plutella xylostella granulovirus isolates from China, Malaysia, and Taiwan exhibiting pairs of noncoding, homologous repeat regions with significant sequence variation but equivalent length. Copyright © 2016 Spence et al.

  11. LABORATORY CAPACITY NEEDS ASSESSMENT OF DRINKING WATER UTILITIES: A GLOBAL PERSPECTIVE

    EPA Science Inventory

    Fully-functioning analytical laboratories capable of producing quality data are essential components of well-run drinking water utilities. In Europe and the US, drinking water laboratory performance is closely monitored and regulated; this is not always the case in the less indu...

  12. THE GLOBAL PERSPECTIVES AND HOW CAN THE ETV SCHEMES COOPERATE

    EPA Science Inventory

    Canada, the European Commission and US Environmental Technology Verification (ETV) programs have established an international group to develop a common approach to ETV. This group is also welcoming new members who have either a fully operating or pilot ETV program. The group ha...

  13. Modeling lakes and reservoirs in the climate system

    USGS Publications Warehouse

    MacKay, M.D.; Neale, P.J.; Arp, C.D.; De Senerpont Domis, L. N.; Fang, X.; Gal, G.; Jo, K.D.; Kirillin, G.; Lenters, J.D.; Litchman, E.; MacIntyre, S.; Marsh, P.; Melack, J.; Mooij, W.M.; Peeters, F.; Quesada, A.; Schladow, S.G.; Schmid, M.; Spence, C.; Stokes, S.L.

    2009-01-01

    Modeling studies examining the effect of lakes on regional and global climate, as well as studies on the influence of climate variability and change on aquatic ecosystems, are surveyed. Fully coupled atmosphere-land surface-lake climate models that could be used for both of these types of study simultaneously do not presently exist, though there are many applications that would benefit from such models. It is argued here that current understanding of physical and biogeochemical processes in freshwater systems is sufficient to begin to construct such models, and a path forward is proposed. The largest impediment to fully representing lakes in the climate system lies in the handling of lakes that are too small to be explicitly resolved by the climate model, and that make up the majority of the lake-covered area at the resolutions currently used by global and regional climate models. Ongoing development within the hydrological sciences community and continual improvements in model resolution should help ameliorate this issue.

  14. A 2017 Horizon Scan of Emerging Issues for Global Conservation and Biological Diversity.

    PubMed

    Sutherland, William J; Barnard, Phoebe; Broad, Steven; Clout, Mick; Connor, Ben; Côté, Isabelle M; Dicks, Lynn V; Doran, Helen; Entwistle, Abigail C; Fleishman, Erica; Fox, Marie; Gaston, Kevin J; Gibbons, David W; Jiang, Zhigang; Keim, Brandon; Lickorish, Fiona A; Markillie, Paul; Monk, Kathryn A; Pearce-Higgins, James W; Peck, Lloyd S; Pretty, Jules; Spalding, Mark D; Tonneijck, Femke H; Wintle, Bonnie C; Ockendon, Nancy

    2017-01-01

    We present the results of our eighth annual horizon scan of emerging issues likely to affect global biological diversity, the environment, and conservation efforts in the future. The potential effects of these novel issues might not yet be fully recognized or understood by the global conservation community, and the issues can be regarded as both opportunities and risks. A diverse international team with collective expertise in horizon scanning, science communication, and conservation research, practice, and policy reviewed 100 potential issues and identified 15 that qualified as emerging, with potential substantial global effects. These issues include new developments in energy storage and fuel production, sand extraction, potential solutions to combat coral bleaching and invasive marine species, and blockchain technology. Copyright © 2016 The Authors. Published by Elsevier Ltd.. All rights reserved.

  15. Effect of maturity on phenolics (phenolic acids and flavonoids) profile of strawberry cultivars and mulberry species from Pakistan.

    PubMed

    Mahmood, Tahir; Anwar, Farooq; Abbas, Mateen; Saari, Nazamid

    2012-01-01

    In this study, we investigated how the extent of ripeness affects the yield of extract, total phenolics, total flavonoids, individual flavonols and phenolic acids in strawberry and mulberry cultivars from Pakistan. In strawberry, the yield of extract (%), total phenolics (TPC) and total flavonoids (TFC) ranged from 8.5-53.3%, 491-1884 mg gallic acid equivalents (GAE)/100 g DW and 83-327 mg catechin equivalents (CE)/100 g DW, respectively. For the different species of mulberry the yield of extract (%), total phenolics and total flavonoids of 6.9-54.0%, 201-2287 mg GAE/100 g DW and 110-1021 mg CE/100 g DW, respectively, varied significantly as fruit maturity progressed. The amounts of individual flavonols and phenolic acid in selected berry fruits were analyzed by RP-HPLC. Among the flavonols, the content of myricetin was found to be high in Morus alba (88 mg/100 g DW), the amount of quercetin as high in Morus laevigata (145 mg/100 g DW) while kaempferol was highest in the Korona strawberry (98 mg/100 g DW) at fully ripened stage. Of the six phenolic acids detected, p-hydroxybenzoic and p-coumaric acid were the major compounds in the strawberry. M. laevigata and M. nigra contained p-coumaric acid and vanillic acid while M. macroura and M. alba contained p-hydroxy-benzoic acid and chlorogenic acid as the major phenolic acids. Overall, a trend to an increase in the percentage of extraction yield, TPC, TFC, flavonols and phenolic acids was observed as maturity progressed from un-ripened to fully-ripened stages.

  16. Parallel Transport with Sheath and Collisional Effects in Global Electrostatic Turbulent Transport in FRCs

    NASA Astrophysics Data System (ADS)

    Bao, Jian; Lau, Calvin; Kuley, Animesh; Lin, Zhihong; Fulton, Daniel; Tajima, Toshiki; Tri Alpha Energy, Inc. Team

    2017-10-01

    Collisional and turbulent transport in a field reversed configuration (FRC) is studied in global particle simulation by using GTC (gyrokinetic toroidal code). The global FRC geometry is incorporated in GTC by using a field-aligned mesh in cylindrical coordinates, which enables global simulation coupling core and scrape-off layer (SOL) across the separatrix. Furthermore, fully kinetic ions are implemented in GTC to treat magnetic-null point in FRC core. Both global simulation coupling core and SOL regions and independent SOL region simulation have been carried out to study turbulence. In this work, the ``logical sheath boundary condition'' is implemented to study parallel transport in the SOL. This method helps to relax time and spatial steps without resolving electron plasma frequency and Debye length, which enables turbulent transports simulation with sheath effects. We will study collisional and turbulent SOL parallel transport with mirror geometry and sheath boundary condition in C2-W divertor.

  17. Networks of global bird invasion altered by regional trade ban

    PubMed Central

    Reino, Luís; Figueira, Rui; Beja, Pedro; Araújo, Miguel B.; Capinha, César; Strubbe, Diederik

    2017-01-01

    Wildlife trade is a major pathway for introduction of invasive species worldwide. However, how exactly wildlife trade influences invasion risk, beyond the transportation of individuals to novel areas, remains unknown. We analyze the global trade network of wild-caught birds from 1995 to 2011 as reported by CITES (Convention on International Trade in Endangered Species of Wild Fauna and Flora). We found that before the European Union ban on imports of wild-caught birds, declared in 2005, invasion risk was closely associated with numbers of imported birds, diversity of import sources, and degree of network centrality of importer countries. After the ban, fluxes of global bird trade declined sharply. However, new trade routes emerged, primarily toward the Nearctic, Afrotropical, and Indo-Malay regions. Although regional bans can curtail invasion risk globally, to be fully effective and prevent rerouting of trade flows, bans should be global. PMID:29181443

  18. Networks of global bird invasion altered by regional trade ban.

    PubMed

    Reino, Luís; Figueira, Rui; Beja, Pedro; Araújo, Miguel B; Capinha, César; Strubbe, Diederik

    2017-11-01

    Wildlife trade is a major pathway for introduction of invasive species worldwide. However, how exactly wildlife trade influences invasion risk, beyond the transportation of individuals to novel areas, remains unknown. We analyze the global trade network of wild-caught birds from 1995 to 2011 as reported by CITES (Convention on International Trade in Endangered Species of Wild Fauna and Flora). We found that before the European Union ban on imports of wild-caught birds, declared in 2005, invasion risk was closely associated with numbers of imported birds, diversity of import sources, and degree of network centrality of importer countries. After the ban, fluxes of global bird trade declined sharply. However, new trade routes emerged, primarily toward the Nearctic, Afrotropical, and Indo-Malay regions. Although regional bans can curtail invasion risk globally, to be fully effective and prevent rerouting of trade flows, bans should be global.

  19. Planning for Coupling Effects in Bitoric Mixed Astigmatism Ablative Treatments.

    PubMed

    Alpins, Noel; Ong, James K Y; Stamatelatos, George

    2017-08-01

    To demonstrate how to determine the historical coupling adjustments of bitoric mixed astigmatism ablative treatments and how to use these historical coupling adjustments to adjust future bitoric treatments. The individual coupling adjustments of the myopic and hyperopic cylindrical components of a bitoric treatment were derived empirically from a retrospective study where the theoretical combined treatment effect on spherical equivalent was compared to the actual change in refractive spherical equivalent. The coupling adjustments that provided the best fit in both mean and standard deviation were determined to be the historical coupling adjustments. Theoretical treatments that incorporated the historical coupling adjustments were then calculated. The actual distribution of postoperative spherical equivalent errors was compared to the theoretically adjusted distribution. The study group comprised 242 eyes and included 118 virgin right eyes and 124 virgin left eyes of 155 individuals. For the laser used, the myopic coupling adjustment was -0.02 and the hyperopic coupling adjustment was 0.30, as derived by global nonlinear optimization. This implies that almost no adjustment of the myopic component of the bitoric treatment is necessary, but that the hyperopic component of the bitoric treatment generates a large amount of unintended spherical shift. The theoretically adjusted treatments targeted zero mean spherical equivalent error, as intended, and the distribution of the theoretical spherical equivalent errors had the same spread as the distribution of actual postoperative spherical equivalent errors. Bitoric mixed astigmatism ablative treatments may display non-trivial coupling effects. Historical coupling adjustments should be taken into consideration when planning mixed astigmatism treatments to improve surgical outcomes. [J Refract Surg. 2017;33(8):545-551.]. Copyright 2017, SLACK Incorporated.

  20. Method and basis set dependence of anharmonic ground state nuclear wave functions and zero-point energies: application to SSSH.

    PubMed

    Kolmann, Stephen J; Jordan, Meredith J T

    2010-02-07

    One of the largest remaining errors in thermochemical calculations is the determination of the zero-point energy (ZPE). The fully coupled, anharmonic ZPE and ground state nuclear wave function of the SSSH radical are calculated using quantum diffusion Monte Carlo on interpolated potential energy surfaces (PESs) constructed using a variety of method and basis set combinations. The ZPE of SSSH, which is approximately 29 kJ mol(-1) at the CCSD(T)/6-31G* level of theory, has a 4 kJ mol(-1) dependence on the treatment of electron correlation. The anharmonic ZPEs are consistently 0.3 kJ mol(-1) lower in energy than the harmonic ZPEs calculated at the Hartree-Fock and MP2 levels of theory, and 0.7 kJ mol(-1) lower in energy at the CCSD(T)/6-31G* level of theory. Ideally, for sub-kJ mol(-1) thermochemical accuracy, ZPEs should be calculated using correlated methods with as big a basis set as practicable. The ground state nuclear wave function of SSSH also has significant method and basis set dependence. The analysis of the nuclear wave function indicates that SSSH is localized to a single symmetry equivalent global minimum, despite having sufficient ZPE to be delocalized over both minima. As part of this work, modifications to the interpolated PES construction scheme of Collins and co-workers are presented.

  1. Method and basis set dependence of anharmonic ground state nuclear wave functions and zero-point energies: Application to SSSH

    NASA Astrophysics Data System (ADS)

    Kolmann, Stephen J.; Jordan, Meredith J. T.

    2010-02-01

    One of the largest remaining errors in thermochemical calculations is the determination of the zero-point energy (ZPE). The fully coupled, anharmonic ZPE and ground state nuclear wave function of the SSSH radical are calculated using quantum diffusion Monte Carlo on interpolated potential energy surfaces (PESs) constructed using a variety of method and basis set combinations. The ZPE of SSSH, which is approximately 29 kJ mol-1 at the CCSD(T)/6-31G∗ level of theory, has a 4 kJ mol-1 dependence on the treatment of electron correlation. The anharmonic ZPEs are consistently 0.3 kJ mol-1 lower in energy than the harmonic ZPEs calculated at the Hartree-Fock and MP2 levels of theory, and 0.7 kJ mol-1 lower in energy at the CCSD(T)/6-31G∗ level of theory. Ideally, for sub-kJ mol-1 thermochemical accuracy, ZPEs should be calculated using correlated methods with as big a basis set as practicable. The ground state nuclear wave function of SSSH also has significant method and basis set dependence. The analysis of the nuclear wave function indicates that SSSH is localized to a single symmetry equivalent global minimum, despite having sufficient ZPE to be delocalized over both minima. As part of this work, modifications to the interpolated PES construction scheme of Collins and co-workers are presented.

  2. Human impacts on terrestrial hydrology: climate change versus pumping and irrigation

    NASA Astrophysics Data System (ADS)

    Ferguson, Ian M.; Maxwell, Reed M.

    2012-12-01

    Global climate change is altering terrestrial water and energy budgets, with subsequent impacts on surface and groundwater resources; recent studies have shown that local water management practices such as groundwater pumping and irrigation similarly alter terrestrial water and energy budgets over many agricultural regions, with potential feedbacks on weather and climate. Here we use a fully-integrated hydrologic model to directly compare effects of climate change and water management on terrestrial water and energy budgets of a representative agricultural watershed in the semi-arid Southern Great Plains, USA. At local scales, we find that the impacts of pumping and irrigation on latent heat flux, potential recharge and water table depth are similar in magnitude to the impacts of changing temperature and precipitation; however, the spatial distributions of climate and management impacts are substantially different. At the basin scale, the impacts on stream discharge and groundwater storage are remarkably similar. Notably, for the watershed and scenarios studied here, the changes in groundwater storage and stream discharge in response to a 2.5 °C temperature increase are nearly equivalent to those from groundwater-fed irrigation. Our results imply that many semi-arid basins worldwide that practice groundwater pumping and irrigation may already be experiencing similar impacts on surface water and groundwater resources to a warming climate. These results demonstrate that accurate assessment of climate change impacts and development of effective adaptation and mitigation strategies must account for local water management practices.

  3. Catalytic Conversion of Carbohydrates to Initial Platform Chemicals: Chemistry and Sustainability.

    PubMed

    Mika, László T; Cséfalvay, Edit; Németh, Áron

    2018-01-24

    The replacement of fossil resources that currently provide more than 90% of our energy needs and feedstocks of the chemical industry in combination with reduced emission of carbon dioxide is one of the most pressing challenges of mankind. Biomass as a globally available resource has been proposed as an alternative feedstock for production of basic building blocks, which could partially or even fully replace the currently utilized fossil-based ones in well-established chemical processes. The destruction of lignocellulosic feed followed by oxygen removal from its cellulose and hemicellulose content by catalytic processes results in the formation of initial platform chemicals (IPCs). However, their sustainable production strongly depends on the availability of resources, their efficient or even industrially viable conversion processes, and replenishment time of feedstocks. Herein, we overview recent advances and developments in catalytic transformations of the carbohydrate content of lignocellulosic biomass to IPCs (i.e., ethanol, 3-hydroxypropionic acid, isoprene, succinic and levulinic acids, furfural, and 5-hydroxymethylfurfural). The mechanistic aspects, development of new catalysts, different efficiency indicators (yield and selectivity), and conversion conditions of their production are presented and compared. The potential biochemical production routes utilizing recently engineered microorganisms are reviewed, as well. The sustainability metrics that could be applied to the chemical industry (individual set of sustainability indicators, composite indices methods, material and energy flow analysis-based metrics, and ethanol equivalents) are also overviewed as well as an outlook is provided to highlight challenges and opportunities associated with this huge research area.

  4. Performance and characterization of new micromachined high-frequency linear arrays.

    PubMed

    Lukacs, Marc; Yin, Jianhua; Pang, Guofeng; Garcia, Richard C; Cherin, Emmanuel; Williams, Ross; Mehi, Jim; Foster, F Stuart

    2006-10-01

    A new approach for fabricating high frequency (> 20 MHz) linear array transducers, based on laser micromachining, has been developed. A 30 MHz, 64-element, 74-microm pitch, linear array design is presented. The performance of the device is demonstrated by comparing electrical and acoustic measurements with analytical, equivalent circuit, and finite-element analysis (FEA) simulations. All FEA results for array performance have been generated using one global set of material parameters. Each fabricated array has been integrated onto a flex circuit for ease of handling, and the flex has been integrated onto a custom printed circuit board test card for ease of testing. For a fully assembled array, with an acoustic lens, the center frequency was 28.7 MHz with a one-way -3 dB and -6 dB bandwidth of 59% and 83%, respectively, and a -20 dB pulse width of -99 ns. The per-element peak acoustic power, for a +/- 30 V single cycle pulse, measured at the 10 mm focal length of the lens was 590 kPa with a -6 dB directivity span of about 30 degrees. The worst-case total cross talk of the combined array and flex assembly is for nearest neighboring elements and was measured to have an average level -40 dB across the -6 dB bandwidth of the device. Any significant deviation from simulation can be explained through limitations in apparatus calibration and in device packaging.

  5. Ontogeny of the daily profile of plasma melatonin in European starlings raised under long or short photoperiods.

    PubMed

    Dawson, Alistair; Van't, Hof Thomas J

    2002-06-01

    Photoperiodic manipulation of young European starlings suggests that their reproductive physiology is incapable of responding to a short photoperiod until they are fully grown. This study aimed to determine whether the lack of response to a short photoperiod is reflected in the daily profile of plasma melatonin concentrations. Five-day-old starlings taken from nest boxes showed a significant (p < 0.0001) rhythm in plasma melatonin concentrations, with high values during night. In nestlings hand-reared from 5 days of age on a long photoperiod (LD 16:8), equivalent to natural photoperiod at the time, the amplitude of the daily rhythm in melatonin increased significantly (p < 0.01) with age until birds were fully grown (20 days old). In nestlings reared on a short photoperiod (LD 8:16), the daily melatonin profile remained almost identical to that of long photoperiod birds until they were fully grown. However, after 20 days old, the duration of elevated nighttime melatonin began to extend to encompass the entire period of darkness. In contrast, fully grown starlings transferred from a long to a short photoperiod had partially adapted to the short photoperiod after 5 days; by 10 days, the daily melatonin profile was identical to that of birds held chronically on a short photoperiod. Thus, consistent with responses of reproductive physiology, the pineal of young birds appears to be incapable of perceiving, or adapting to, a short photoperiod.

  6. Colorado River basin sensitivity to disturbance impacts

    NASA Astrophysics Data System (ADS)

    Bennett, K. E.; Urrego-Blanco, J. R.; Jonko, A. K.; Vano, J. A.; Newman, A. J.; Bohn, T. J.; Middleton, R. S.

    2017-12-01

    The Colorado River basin is an important river for the food-energy-water nexus in the United States and is projected to change under future scenarios of increased CO2emissions and warming. Streamflow estimates to consider climate impacts occurring as a result of this warming are often provided using modeling tools which rely on uncertain inputs—to fully understand impacts on streamflow sensitivity analysis can help determine how models respond under changing disturbances such as climate and vegetation. In this study, we conduct a global sensitivity analysis with a space-filling Latin Hypercube sampling of the model parameter space and statistical emulation of the Variable Infiltration Capacity (VIC) hydrologic model to relate changes in runoff, evapotranspiration, snow water equivalent and soil moisture to model parameters in VIC. Additionally, we examine sensitivities of basin-wide model simulations using an approach that incorporates changes in temperature, precipitation and vegetation to consider impact responses for snow-dominated headwater catchments, low elevation arid basins, and for the upper and lower river basins. We find that for the Colorado River basin, snow-dominated regions are more sensitive to uncertainties. New parameter sensitivities identified include runoff/evapotranspiration sensitivity to albedo, while changes in snow water equivalent are sensitive to canopy fraction and Leaf Area Index (LAI). Basin-wide streamflow sensitivities to precipitation, temperature and vegetation are variable seasonally and also between sub-basins; with the largest sensitivities for smaller, snow-driven headwater systems where forests are dense. For a major headwater basin, a 1ºC of warming equaled a 30% loss of forest cover, while a 10% precipitation loss equaled a 90% forest cover decline. Scenarios utilizing multiple disturbances led to unexpected results where changes could either magnify or diminish extremes, such as low and peak flows and streamflow timing, dependent on the strength and direction of the forcing. These results indicate the importance of understanding model sensitivities under disturbance impacts to manage these shifts; plan for future water resource changes and determine how the impacts will affect the sustainability and adaptability of food-energy-water systems.

  7. Key Parameters for the Use of AbobotulinumtoxinA in Aesthetics: Onset and Duration

    PubMed Central

    Ablon, Glynis; Pickett, Andy

    2017-01-01

    Abstract Time to onset of response and duration of response are key measures of botulinum toxin efficacy that have a considerable influence on patient satisfaction with aesthetic treatment. However, there is no overall accepted definition of efficacy for aesthetic uses of botulinumtoxinA (BoNT-A). Mechanical methods of assessment do not lend themselves to clinical practice and clinicians rely instead on assessment scales such as the Frontalis Activity Measurement Standard, Frontalis Rating Scale, Wrinkle Severity Scale, and Subject Global Assessment Scale, but not all of these have been fully validated. Onset of activity is typically seen within 5 days of injection, but has also been recorded within 12 hours with abobotulinumtoxinA. Duration of effect is more variable, and is influenced by parameters such as muscle mass (including the effects of age and sex) and type of product used. Even when larger muscles are treated with higher doses of BoNT-A, the duration of effect is still shorter than that for smaller muscles. Muscle injection technique, including dilution of the toxin, the volume of solution injected, and the positioning of the injections, can also have an important influence on onset and duration of activity. Comparison of the efficacy of different forms of BoNT-A must be made with the full understanding that the dosing units are not equivalent. Range of equivalence studies for abobotulinumtoxinA (Azzalure; Ipsen Limited, Slough UK/Galderma, Lausanne CH/Dysport, Ipsen Biopharm Limited, Wrexham UK/Galderma LP, Fort Worth, TX) and onabotulinumtoxinA (Botox; Allergan, Parsippany, NJ) have been conducted, and results indicate that the number of units of abobotulinumtoxinA needs to be approximately twice as high as that of onabotulinumtoxinA to achieve the same effect. An appreciation of the potential influence of all of the parameters that influence onset and duration of activity of BoNT-A, along with a thorough understanding of the anatomy of the face and potency of doses, are essential to tailoring treatment to individual patient needs and expectations. PMID:28388717

  8. Inverse Design of Low-Boom Supersonic Concepts Using Reversed Equivalent-Area Targets

    NASA Technical Reports Server (NTRS)

    Li, Wu; Rallabhand, Sriam

    2011-01-01

    A promising path for developing a low-boom configuration is a multifidelity approach that (1) starts from a low-fidelity low-boom design, (2) refines the low-fidelity design with computational fluid dynamics (CFD) equivalent-area (Ae) analysis, and (3) improves the design with sonic-boom analysis by using CFD off-body pressure distributions. The focus of this paper is on the third step of this approach, in which the design is improved with sonic-boom analysis through the use of CFD calculations. A new inverse design process for off-body pressure tailoring is formulated and demonstrated with a low-boom supersonic configuration that was developed by using the mixed-fidelity design method with CFD Ae analysis. The new inverse design process uses the reverse propagation of the pressure distribution (dp/p) from a mid-field location to a near-field location, converts the near-field dp/p into an equivalent-area distribution, generates a low-boom target for the reversed equivalent area (Ae,r) of the configuration, and modifies the configuration to minimize the differences between the configuration s Ae,r and the low-boom target. The new inverse design process is used to modify a supersonic demonstrator concept for a cruise Mach number of 1.6 and a cruise weight of 30,000 lb. The modified configuration has a fully shaped ground signature that has a perceived loudness (PLdB) value of 78.5, while the original configuration has a partially shaped aft signature with a PLdB of 82.3.

  9. Symmetry investigations on the incompressible stationary axisymmetric Euler equations with swirl

    NASA Astrophysics Data System (ADS)

    Frewer, M.; Oberlack, M.; Guenther, S.

    2007-08-01

    We discuss the incompressible stationary axisymmetric Euler equations with swirl, for which we derive via a scalar stream function an equivalent representation, the Bragg-Hawthorne equation [Bragg, S.L., Hawthorne, W.R., 1950. Some exact solutions of the flow through annular cascade actuator discs. J. Aero. Sci. 17, 243]. Despite this obvious equivalence, we will show that under a local Lie point symmetry analysis the Bragg-Hawthorne equation exposes itself as not being fully equivalent to the original Euler equations. This is reflected in the way that it possesses additional symmetries not being admitted by its counterpart. In other words, a symmetry of the Bragg-Hawthorne equation is in general not a symmetry of the Euler equations. Not the differential Euler equations but rather a set of integro-differential equations attains full equivalence to the Bragg-Hawthorne equation. For these intermediate Euler equations, it is interesting to note that local symmetries of the Bragg-Hawthorne equation transform to local as well as to nonlocal symmetries. This behaviour, on the one hand, is in accordance with Zawistowski's result [Zawistowski, Z.J., 2001. Symmetries of integro-differential equations. Rep. Math. Phys. 48, 269; Zawistowski, Z.J., 2004. General criterion of invariance for integro-differential equations. Rep. Math. Phys. 54, 341] that it is possible for integro-differential equations to admit local Lie point symmetries. On the other hand, with this transformation process we collect symmetries which cannot be obtained when carrying out a usual local Lie point symmetry analysis. Finally, the symmetry classification of the Bragg-Hawthorne equation is used to find analytical solutions for the phenomenon of vortex breakdown.

  10. Implications of possible interpretations of ‘greenhouse gas balance’ in the Paris Agreement

    PubMed Central

    Millar, R. J.; Allen, M.; Boucher, O.; Cain, M.; Forster, P. M.; Shindell, D.

    2018-01-01

    The main goal of the Paris Agreement as stated in Article 2 is ‘holding the increase in the global average temperature to well below 2°C above pre-industrial levels and pursuing efforts to limit the temperature increase to 1.5°C’. Article 4 points to this long-term goal and the need to achieve ‘balance between anthropogenic emissions by sources and removals by sinks of greenhouse gases'. This statement on ‘greenhouse gas balance’ is subject to interpretation, and clarifications are needed to make it operational for national and international climate policies. We study possible interpretations from a scientific perspective and analyse their climatic implications. We clarify how the implications for individual gases depend on the metrics used to relate them. We show that the way in which balance is interpreted, achieved and maintained influences temperature outcomes. Achieving and maintaining net-zero CO2-equivalent emissions conventionally calculated using GWP100 (100-year global warming potential) and including substantial positive contributions from short-lived climate-forcing agents such as methane would result in a sustained decline in global temperature. A modified approach to the use of GWP100 (that equates constant emissions of short-lived climate forcers with zero sustained emission of CO2) results in global temperatures remaining approximately constant once net-zero CO2-equivalent emissions are achieved and maintained. Our paper provides policymakers with an overview of issues and choices that are important to determine which approach is most appropriate in the context of the Paris Agreement. This article is part of the theme issue ‘The Paris Agreement: understanding the physical and social challenges for a warming world of 1.5°C above pre-industrial levels'. PMID:29610378

  11. Implications of possible interpretations of 'greenhouse gas balance' in the Paris Agreement.

    PubMed

    Fuglestvedt, J; Rogelj, J; Millar, R J; Allen, M; Boucher, O; Cain, M; Forster, P M; Kriegler, E; Shindell, D

    2018-05-13

    The main goal of the Paris Agreement as stated in Article 2 is 'holding the increase in the global average temperature to well below 2°C above pre-industrial levels and pursuing efforts to limit the temperature increase to 1.5°C'. Article 4 points to this long-term goal and the need to achieve 'balance between anthropogenic emissions by sources and removals by sinks of greenhouse gases'. This statement on 'greenhouse gas balance' is subject to interpretation, and clarifications are needed to make it operational for national and international climate policies. We study possible interpretations from a scientific perspective and analyse their climatic implications. We clarify how the implications for individual gases depend on the metrics used to relate them. We show that the way in which balance is interpreted, achieved and maintained influences temperature outcomes. Achieving and maintaining net-zero CO 2 -equivalent emissions conventionally calculated using GWP 100 (100-year global warming potential) and including substantial positive contributions from short-lived climate-forcing agents such as methane would result in a sustained decline in global temperature. A modified approach to the use of GWP 100 (that equates constant emissions of short-lived climate forcers with zero sustained emission of CO 2 ) results in global temperatures remaining approximately constant once net-zero CO 2 -equivalent emissions are achieved and maintained. Our paper provides policymakers with an overview of issues and choices that are important to determine which approach is most appropriate in the context of the Paris Agreement.This article is part of the theme issue 'The Paris Agreement: understanding the physical and social challenges for a warming world of 1.5°C above pre-industrial levels'. © 2018 The Authors.

  12. Integrated assessment of global water scarcity over the 21st century - Part 2: Climate change mitigation policies

    NASA Astrophysics Data System (ADS)

    Hejazi, M. I.; Edmonds, J.; Clarke, L.; Kyle, P.; Davies, E.; Chaturvedi, V.; Eom, J.; Wise, M.; Patel, P.; Calvin, K.

    2013-03-01

    We investigate the effects of emission mitigation policies on water scarcity both globally and regionally using the Global Change Assessment Model (GCAM), a leading community integrated assessment model of energy, agriculture, climate, and water. Three climate policy scenarios with increasing mitigation stringency of 7.7, 5.5, and 4.2 W m-2 in year 2095 (equivalent to the SRES A2, B2, and B1 emission scenarios, respectively), under two carbon tax regimes (a universal carbon tax (UCT) which includes land use change emissions, and a fossil fuel and industrial emissions carbon tax (FFICT) which excludes land use change emissions) are analyzed. The results are compared to a baseline scenario (i.e. no climate change mitigation policy) with radiative forcing reaching 8.8 W m-2 (equivalent to the SRES A1Fi emission scenario) by 2095. When compared to the baseline scenario and maintaining the same baseline socioeconomic assumptions, water scarcity declines under a UCT mitigation policy but increases with a FFICT mitigation scenario by the year 2095 particularly with more stringent climate mitigation targets. The decreasing trend with UCT policy stringency is due to substitution from more water-intensive to less water-intensive choices in food and energy production, and in land use. Under the FFICT scenario, water scarcity is projected to increase driven by higher water demands for bio-energy crops. This study implies an increasingly prominent role for water availability in future human decisions, and highlights the importance of including water in integrated assessment of global change. Future research will be directed at incorporating water shortage feedbacks in GCAM to better understand how such stresses will propagate across the various human and natural systems in GCAM.

  13. Implications of possible interpretations of `greenhouse gas balance' in the Paris Agreement

    NASA Astrophysics Data System (ADS)

    Fuglestvedt, J.; Rogelj, J.; Millar, R. J.; Allen, M.; Boucher, O.; Cain, M.; Forster, P. M.; Kriegler, E.; Shindell, D.

    2018-05-01

    The main goal of the Paris Agreement as stated in Article 2 is `holding the increase in the global average temperature to well below 2°C above pre-industrial levels and pursuing efforts to limit the temperature increase to 1.5°C'. Article 4 points to this long-term goal and the need to achieve `balance between anthropogenic emissions by sources and removals by sinks of greenhouse gases'. This statement on `greenhouse gas balance' is subject to interpretation, and clarifications are needed to make it operational for national and international climate policies. We study possible interpretations from a scientific perspective and analyse their climatic implications. We clarify how the implications for individual gases depend on the metrics used to relate them. We show that the way in which balance is interpreted, achieved and maintained influences temperature outcomes. Achieving and maintaining net-zero CO2-equivalent emissions conventionally calculated using GWP100 (100-year global warming potential) and including substantial positive contributions from short-lived climate-forcing agents such as methane would result in a sustained decline in global temperature. A modified approach to the use of GWP100 (that equates constant emissions of short-lived climate forcers with zero sustained emission of CO2) results in global temperatures remaining approximately constant once net-zero CO2-equivalent emissions are achieved and maintained. Our paper provides policymakers with an overview of issues and choices that are important to determine which approach is most appropriate in the context of the Paris Agreement. This article is part of the theme issue `The Paris Agreement: understanding the physical and social challenges for a warming world of 1.5°C above pre-industrial levels'.

  14. Integrated assessment of global water scarcity over the 21st century - Part 2: Climate change mitigation policies

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Hejazi, Mohamad I.; Edmonds, James A.; Clarke, Leon E.

    2013-01-01

    We investigate the effects of emission mitigation policies on water scarcity both globally and regionally using the Global Change Assessment Model (GCAM), a leading community integrated assessment model of energy, agriculture, climate, and water. Three climate policy scenarios with increasing mitigation stringency of 7.7, 5.5, and 4.2 W/m2 in year 2095 (equivalent to the SRES A2, B2, and B1 emission scenarios, respectively), under two carbon tax regimes (a universal carbon tax (UCT) which includes land use change emissions, and a fossil fuel and industrial emissions carbon tax (FFICT) which excludes land use change emissions) are analyzed. The results are comparedmore » to a baseline scenario (i.e., no climate change mitigation policy) with radiative forcing reaching 8.8 W/m2 (equivalent to the SRES A1Fi emission scenario) by 2095. When compared to the baseline scenario and maintaining the same baseline underlying socioeconomic assumptions, water scarcity declines under a UCT mitigation policy while increases with a FFICT mitigation scenario by the year 2095 with more stringent climate mitigation targets. The decreasing trend with UCT policy stringency is due to substitution from more water-intensive to less water-intensive choices in food, energy, and land use. Under the FFICT scenario, water scarcity is projected to increase driven by higher water demands for bio-energy crops. This study implies an increasingly prominent role for water availability in future human decisions, and highlights the importance of including water in integrated assessment of global change. Future research will be directed at incorporating water shortage feedbacks in GCAM to better understand how such stresses will propagate across the various human and natural systems in GCAM.« less

  15. Global surface density of water mass variations by using a two-step inversion by cumulating daily satellite gravity information

    NASA Astrophysics Data System (ADS)

    Ramillien, Guillaume; Frappart, Frédéric; Seoane, Lucia

    2016-04-01

    We propose a new method to produce time series of global maps of surface mass variations by progressive integration of daily geopotential variations measured by orbiting satellites. In the case of the GRACE mission, these geopotential variations can be determined from very accurate inter-satellite K-Band Range Rate (KBRR) measurements of 5-second daily orbits. In particular, the along-track gravity contribution of hydrological mass changes is extracted by removing de-aliasing models for static field, atmosphere, oceans mass variations (including periodical tides), as well as polar movements. Our determination of surface mass sources is composed of two successive dependent Kalman filter stages. The first one consists of reducing the satellite-based potential anomalies by adjusting the longest spatial wavelengths (i.e., low-degree spherical harmonics lower than 2). In the second stage, the residual potential anomalies from the previous stage are used to recover surface mass density changes - in terms of Equivalent-Water Height (EWH) - over a global network of juxtaposed triangular elements. These surface tiles of ~100,000 km x km (or equivalently 330 km by 330 km) are defined to be of equal areas over the terrestrial sphere. However they can be adapted to the local geometry of the surface mass. Our global approach was tested by inverting geopotential data, and successfully applied to estimate time-varying surface mass densities from real GRACE-based residuals. This strategy of combined Kalman filter-type inversions can also be useful for exploring the possibility of improving time and space resolutions for ocean and land studies that would be hopefully brought by future low altitude geodetic missions.

  16. Building sector feedbacks lead to increased energy demands

    NASA Astrophysics Data System (ADS)

    Hartin, C.; Link, R. P.; Patel, P.; Horowitz, R.; Clarke, L.; Mundra, A.

    2017-12-01

    Typically in human-earth system modeling studies, feedbacks between the earth and human systems are analyzed by passing information between independent models, leading to data errors and poor reproducibility. In this study we explore the two-way feedbacks between the human and earth systems in the building sector of GCAM, an integrated assessment model and, its fully-integrated climate component, Hector. While there is a general agreement in the literature that increasing temperatures will increase cooling energy demands and decrease heating energy demands, there has been no fully-coupled analysis of this dynamic that would, for example, account for the feedbacks on hydrofluorocarbons from increased cooling demands. Using a statistical relationship between global mean temperature change and heating and cooling degree days, we find that the feedbacks on hydrofluorocarbons lead to an increase in global mean temperature of between 0.16 to 0.27 °C in 2100. Demands for electricity increase by about 10% in Africa, while demands decrease in Canada by about 3.0% when taking into account these feedbacks. While the feedbacks between building energy demand and global mean temperature are modest by themselves, this study prompts future research on coupled human-earth system feedbacks, in particular in regards to land, water, and other energy infrastructure.

  17. GLOBAL WATER RESEARCH COALITION: AN INTERNATIONAL COLLABORATION ON WATER RESEARCH

    EPA Science Inventory

    The research needs for drinking water far exceed the ability of any one research organization to fully address by itself. For this reason, the U.S. Environmental Protection Agency's (U.S.EPA) Office of Research and Development (ORD) historically has sought opportunities to levera...

  18. Challenges in Interpreting and Validating Satellite Soil Moisture Information

    USDA-ARS?s Scientific Manuscript database

    Global soil moisture products are now being generated routinely using microwave-based satellite observing systems. These include the NASA Soil Moisture Active Passive (SMAP) mission. In order to fully exploit these observations they must be integrated with both in situ measurements and model-based e...

  19. Identifying STEM Concepts Associated with Junior Livestock Projects

    ERIC Educational Resources Information Center

    Wooten, Kate; Rayfield, John; Moore, Lori L.

    2013-01-01

    Science, technology, engineering, and mathematics (STEM) education is intended to provide students with a cross-subject, contextual learning experience. To more fully prepare our nation's students to enter the globally competitive workforce, STEM integration allows students to make connections between the abstract concepts learned in core subject…

  20. Development of a Full-Thickness Human Skin Equivalent In Vitro Model Derived from TERT-Immortalized Keratinocytes and Fibroblasts

    PubMed Central

    Reijnders, Christianne M.A.; van Lier, Amanda; Roffel, Sanne; Kramer, Duco; Scheper, Rik J.

    2015-01-01

    Currently, human skin equivalents (HSEs) used for in vitro assays (e.g., for wound healing) make use of primary human skin cells. Limitations of primary keratinocytes and fibroblasts include availability of donor skin and donor variation. The use of physiologically relevant cell lines could solve these limitations. The aim was to develop a fully differentiated HSE constructed entirely from human skin cell lines, which could be applied for in vitro wound-healing assays. Skin equivalents were constructed from human TERT-immortalized keratinocytes and fibroblasts (TERT-HSE) and compared with native skin and primary HSEs. HSEs were characterized by hematoxylin–eosin and immunohistochemical stainings with markers for epidermal proliferation and differentiation, basement membrane (BM), fibroblasts, and the extracellular matrix (ECM). Ultrastructure was determined with electron microscopy. To test the functionality of the TERT-HSE, burn and cold injuries were applied, followed by immunohistochemical stainings, measurement of reepithelialization, and determination of secreted wound-healing mediators. The TERT-HSE was composed of a fully differentiated epidermis and a fibroblast-populated dermis comparable to native skin and primary HSE. The epidermis consisted of proliferating keratinocytes within the basal layer, followed by multiple spinous layers, a granular layer, and cornified layers. Within the TERT-HSE, the membrane junctions such as corneosomes, desmosomes, and hemidesmosomes were well developed as shown by ultrastructure pictures. Furthermore, the BM consisted of a lamina lucida and lamina densa comparable to native skin. The dermal matrix of the TERT-HSE was more similar to native skin than the primary construct, since collagen III, an ECM marker, was present in TERT-HSEs and absent in primary HSEs. After wounding, the TERT-HSE was able to reepithelialize and secrete inflammatory wound-healing mediators. In conclusion, the novel TERT-HSE, constructed entirely from human cell lines, provides an excellent opportunity to study in vitro skin biology and can also be used for drug targeting and testing new therapeutics, and ultimately, for incorporating into skin-on-a chip in the future. PMID:26135533

  1. Development of a Full-Thickness Human Skin Equivalent In Vitro Model Derived from TERT-Immortalized Keratinocytes and Fibroblasts.

    PubMed

    Reijnders, Christianne M A; van Lier, Amanda; Roffel, Sanne; Kramer, Duco; Scheper, Rik J; Gibbs, Susan

    2015-09-01

    Currently, human skin equivalents (HSEs) used for in vitro assays (e.g., for wound healing) make use of primary human skin cells. Limitations of primary keratinocytes and fibroblasts include availability of donor skin and donor variation. The use of physiologically relevant cell lines could solve these limitations. The aim was to develop a fully differentiated HSE constructed entirely from human skin cell lines, which could be applied for in vitro wound-healing assays. Skin equivalents were constructed from human TERT-immortalized keratinocytes and fibroblasts (TERT-HSE) and compared with native skin and primary HSEs. HSEs were characterized by hematoxylin-eosin and immunohistochemical stainings with markers for epidermal proliferation and differentiation, basement membrane (BM), fibroblasts, and the extracellular matrix (ECM). Ultrastructure was determined with electron microscopy. To test the functionality of the TERT-HSE, burn and cold injuries were applied, followed by immunohistochemical stainings, measurement of reepithelialization, and determination of secreted wound-healing mediators. The TERT-HSE was composed of a fully differentiated epidermis and a fibroblast-populated dermis comparable to native skin and primary HSE. The epidermis consisted of proliferating keratinocytes within the basal layer, followed by multiple spinous layers, a granular layer, and cornified layers. Within the TERT-HSE, the membrane junctions such as corneosomes, desmosomes, and hemidesmosomes were well developed as shown by ultrastructure pictures. Furthermore, the BM consisted of a lamina lucida and lamina densa comparable to native skin. The dermal matrix of the TERT-HSE was more similar to native skin than the primary construct, since collagen III, an ECM marker, was present in TERT-HSEs and absent in primary HSEs. After wounding, the TERT-HSE was able to reepithelialize and secrete inflammatory wound-healing mediators. In conclusion, the novel TERT-HSE, constructed entirely from human cell lines, provides an excellent opportunity to study in vitro skin biology and can also be used for drug targeting and testing new therapeutics, and ultimately, for incorporating into skin-on-a chip in the future.

  2. The novel 2016 WHO Neisseria gonorrhoeae reference strains for global quality assurance of laboratory investigations: phenotypic, genetic and reference genome characterization.

    PubMed

    Unemo, Magnus; Golparian, Daniel; Sánchez-Busó, Leonor; Grad, Yonatan; Jacobsson, Susanne; Ohnishi, Makoto; Lahra, Monica M; Limnios, Athena; Sikora, Aleksandra E; Wi, Teodora; Harris, Simon R

    2016-11-01

    Gonorrhoea and MDR Neisseria gonorrhoeae remain public health concerns globally. Enhanced, quality-assured, gonococcal antimicrobial resistance (AMR) surveillance is essential worldwide. The WHO global Gonococcal Antimicrobial Surveillance Programme (GASP) was relaunched in 2009. We describe the phenotypic, genetic and reference genome characteristics of the 2016 WHO gonococcal reference strains intended for quality assurance in the WHO global GASP, other GASPs, diagnostics and research worldwide. The 2016 WHO reference strains (n = 14) constitute the eight 2008 WHO reference strains and six novel strains. The novel strains represent low-level to high-level cephalosporin resistance, high-level azithromycin resistance and a porA mutant. All strains were comprehensively characterized for antibiogram (n = 23), serovar, prolyliminopeptidase, plasmid types, molecular AMR determinants, N. gonorrhoeae multiantigen sequence typing STs and MLST STs. Complete reference genomes were produced using single-molecule PacBio sequencing. The reference strains represented all available phenotypes, susceptible and resistant, to antimicrobials previously and currently used or considered for future use in gonorrhoea treatment. All corresponding resistance genotypes and molecular epidemiological types were described. Fully characterized, annotated and finished references genomes (n = 14) were presented. The 2016 WHO gonococcal reference strains are intended for internal and external quality assurance and quality control in laboratory investigations, particularly in the WHO global GASP and other GASPs, but also in phenotypic (e.g. culture, species determination) and molecular diagnostics, molecular AMR detection, molecular epidemiology and as fully characterized, annotated and finished reference genomes in WGS analysis, transcriptomics, proteomics and other molecular technologies and data analysis. © The Author 2016. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

  3. Fully reprocessed ERS-1 altimeter data from 1992 to 1995: Feasibility of the detection of long term sea level change

    NASA Astrophysics Data System (ADS)

    Anzenhofer, M.; Gruber, T.

    1998-04-01

    Global mean sea level observations are necessary to answer the urgent questions about climate changes and their impact on socio-economy. At GeoForschungsZentrum/Geman Processing and Archiving Facility ERS altimeter data is used to systematically generate geophysical products such as sea surface topography, high-resolution geoid and short- and long-period sea surface height models. On the basis of this experience, fully reprocessed ERS-1 altimeter data is used to generated a time series of monthly sea surface height models from April 1992 to April 1995. The reprocessing consists of improved satellite ephemerides, merging of Grenoble tidal model, and application of range corrections due to timing errors. With the new data set the TOPEX/POSEIDON prelaunch accuracy requirements are fulfilled. The 3-year time series is taken to estimate the rate of change of global mean sea level. A careful treatment of seasonal effects is considered. A masking of continents, sea ice, and suspect sea surface heights is chosen that is common for all sea surface height models. The obtained rate of change is compared to external results from tide gauge records and TOPEX/POSEIDON data. The relation of sea level changes and sea surface temperature variations is examined by means of global monthly sea surface temperature maps. Both global wind speed and wave height maps are investigated and correlated with sea surface heights and sea surface temperatures in order to find other indicators of climate variations. The obtained rate of changes of the various global maps is compared to an atmospheric CO2 anomaly record, which is highly correlated to El Niño events. The relatively short period of 3 years, however, does not allow definite conclusions with respect to possible long-term climate changes.

  4. Evaluating the relation between memory and intelligence in children with learning disabilities.

    PubMed

    Hoerig, Dianne C; David, Andrew S; D'Amato, Rik Carl

    2002-12-01

    Although both intelligence tests and memory tests are commonly used in neuropsychological examinations, the relationship between memory and intelligence has not been fully explored, particularly for children having learning disabilities. Memory, or the ability to retain information, was evaluated using the Test of Memory and Learning, a recently released test that gives a comprehensive measure of global memory functioning. This, and the Wechsler Intelligence Scale for Children-Third Edition, used to assess intelligence, were given to 80 students with learning disabilities. The correlation between a global measure of memory and a global measure f intelligence was significant (r = .59), indicating that memory should be viewed as an important component when evaluating children with learning disabilities.

  5. Forecasting carbon dioxide emissions.

    PubMed

    Zhao, Xiaobing; Du, Ding

    2015-09-01

    This study extends the literature on forecasting carbon dioxide (CO2) emissions by applying the reduced-form econometrics approach of Schmalensee et al. (1998) to a more recent sample period, the post-1997 period. Using the post-1997 period is motivated by the observation that the strengthening pace of global climate policy may have been accelerated since 1997. Based on our parameter estimates, we project 25% reduction in CO2 emissions by 2050 according to an economic and population growth scenario that is more consistent with recent global trends. Our forecasts are conservative due to that we do not have sufficient data to fully take into account recent developments in the global economy. Copyright © 2015 Elsevier Ltd. All rights reserved.

  6. Implications of possible interpretations of "greenhouse gas balance" in the Paris Agreement

    NASA Astrophysics Data System (ADS)

    Millar, R.; Fuglestvedt, J. S.; Rogelj, J.; Allen, M. R.; Boucher, O.; Forster, P.; Kriegler, E.; Shindell, D. T.

    2017-12-01

    The main goal of the Paris Agreement as stated in its Article 2 is "Holding the increase in the global average temperature to well below 2°C above pre-industrial levels and pursuing efforts to limit the temperature increase to 1.5°C above pre-industrial levels…". Article 4 points to this long-term goal and the need to "… achieve balance between anthropogenic emissions by sources and removals by sinks of greenhouse gases …". The statement on "greenhouse gas balance" is subject to interpretation, and several clarifications are needed in order to make it operational for implementation in climate policies. Here we study possible interpretations from a scientific perspective and analyze their climatic implications. We clarify how the balance referred to in Article 4 of the Paris Agreement applies to anthropogenic sources and anthropogenic sinks and how the implications for individual gases depends strongly on the emission metrics used to relate them. We also show that the way in which balance is interpreted, achieved and maintained influences the anticipated temperature outcome over time. For example, achieving and maintaining net zero CO2-equivalent emissions calculated with the widely used metric Global Warming Potential with a horizon of 100 years (GWP100) - adopted for the implementation of the Kyoto Protocol and in UNFCCC reporting - would result in a peak and decline in global mean temperature. Adopting a different metric, like GWP* (Allen et al., 2016), would result in global mean temperatures remaining approximately constant once net zero CO2-equivalent emissions are achieved and maintained. Policymakers should be aware of these issues and choices and determine which approach is most appropriate in the context of the goals of the Paris Agreement.Reference:Allen, Fuglestvedt, Shine, Reisinger, Pierrehumbert, Forster: New use of global warming potentials to compare cumulative and short-lived climate pollutants. Nature Climate Change (2016). doi:10.1038/nclimate2998

  7. Paleobotany and Global Change: Important Lessons for Species to Biomes from Vegetation Responses to Past Global Change.

    PubMed

    McElwain, Jennifer C

    2018-04-29

    Human carbon use during the next century will lead to atmospheric carbon dioxide concentrations (pCO 2 ) that have been unprecedented for the past 50-100+ million years according to fossil plant-based CO 2 estimates. The paleobotanical record of plants offers key insights into vegetation responses to past global change, including suitable analogs for Earth's climatic future. Past global warming events have resulted in transient poleward migration at rates that are equivalent to the lowest climate velocities required for current taxa to keep pace with climate change. Paleobiome reconstructions suggest that the current tundra biome is the biome most threatened by global warming. The common occurrence of paleoforests at high polar latitudes when pCO 2 was above 500 ppm suggests that the advance of woody shrub and tree taxa into tundra environments may be inevitable. Fossil pollen studies demonstrate the resilience of wet tropical forests to global change up to 700 ppm CO 2 , contrary to modeled predictions of the future. The paleobotanical record also demonstrates a high capacity for functional trait evolution as an additional strategy to migration and maintenance of a species' climate envelope in response to global change.

  8. Worldwide orthopaedic research activity 2010-2014: Publication rates in the top 15 orthopaedic journals related to population size and gross domestic product.

    PubMed

    Hohmann, Erik; Glatt, Vaida; Tetsworth, Kevin

    2017-06-18

    To perform a bibliometric analysis of publications rates in orthopedics in the top 15 orthopaedic journals. Based on their 2015 impact factor, the fifteen highest ranked orthopaedic journals between January 2010 and December 2014 were used to establish the total number of publications; cumulative impact factor points (IF) per country were determined, and normalized to population size, GDP, and GDP/capita, comparison to the median country output and the global leader. Twenty-three thousand and twenty-one orthopaedic articles were published, with 66 countries publishing. The United States had 8149 publications, followed by the United Kingdom (1644) and Japan (1467). The highest IF was achieved by the United States (24744), United Kingdom (4776), and Japan (4053). Normalized by population size Switzerland lead. Normalized by GDP, Croatia was the top achiever. Adjusting GDP/capita, for publications and IF, China, India, and the United States were the leaders. Adjusting for population size and GDP, 28 countries achieved numbers of publications to be considered at least equivalent with the median academic output. Adjusting GDP/capita only China and India reached the number of publications to be considered equivalent to the current global leader, the United States. Five countries were responsible for 60% of the orthopaedic research output over this 5-year period. After correcting for GDP/capita, only 28 of 66 countries achieved a publication rate equivalent to the median country. The United States, United Kingdom, South Korea, Japan, and Germany were the top five countries for both publication totals and cumulative impact factor points.

  9. Lack of broad functional differences in immunity in fully vaccinated vs. unvaccinated children.

    PubMed

    Sherrid, Ashley M; Ruck, Candice E; Sutherland, Darren; Cai, Bing; Kollmann, Tobias R

    2017-04-01

    Concerns have been raised that with an increase in the number of vaccines administered early in life, immune development could be altered, leading to either increased or decreased immune reactivity. We investigated the impact of vaccination on immune status, contrasting the immune response to general, nonantigen-specific stimuli in a cohort of entirely unvaccinated vs. fully vaccinated children at 3-5 y of age. Innate immunity was assessed by quantifying bulk and cell-type-specific cytokine production in response to stimulation with pathogen associated microbial patterns. Adaptive immune status was characterized by assessing lymphocyte proliferation and cytokine production in response to generic T cell stimuli. Our investigations failed to reveal a broadly evident alteration of either innate or adaptive immunity in vaccinated children. Equivalently robust innate and adaptive responses to pathogen associated microbial patterns and generic T cell stimulants were observed in both groups. Although our sample size was small, our data suggest that standard childhood vaccinations do not lead to long-lasting gross alterations of the immune system.

  10. Evaluating Nonattachment and Decentering as Possible Mediators of the Link Between Mindfulness and Psychological Distress in a Nonclinical College Sample.

    PubMed

    Bhambhani, Yash; Cabral, Gail

    2016-10-01

    Although increasing evidence shows that mindfulness is positively related to mental health, the nature and mechanisms of this relationship are not fully understood. Based on previous research findings and suggestions, the authors of the current study hypothesized that decentering and nonattachment are 2 variables that mediate the relationship between mindfulness and psychological distress. A nonclinical, non-treatment-seeking sample of 308 students and employees from a middle-class, primarily Caucasian university filled out mindfulness, decentering, nonattachment, and mental distress measures online. Mediational analyses failed to support the hypothesis. Results suggest that mindfulness and nonattachment are independent predictors of nonclinical psychological distress and fully explain the effect of decentering on psychological distress. Results should be interpreted with caution and not generalized to clinical issues. A more comprehensive look into the mechanisms of mindfulness, especially with rigorous experimental, longitudinal studies, is warranted. The authors stress the importance of checking alternative, equivalent models in mediation studies. © The Author(s) 2015.

  11. Human semi-supervised learning.

    PubMed

    Gibson, Bryan R; Rogers, Timothy T; Zhu, Xiaojin

    2013-01-01

    Most empirical work in human categorization has studied learning in either fully supervised or fully unsupervised scenarios. Most real-world learning scenarios, however, are semi-supervised: Learners receive a great deal of unlabeled information from the world, coupled with occasional experiences in which items are directly labeled by a knowledgeable source. A large body of work in machine learning has investigated how learning can exploit both labeled and unlabeled data provided to a learner. Using equivalences between models found in human categorization and machine learning research, we explain how these semi-supervised techniques can be applied to human learning. A series of experiments are described which show that semi-supervised learning models prove useful for explaining human behavior when exposed to both labeled and unlabeled data. We then discuss some machine learning models that do not have familiar human categorization counterparts. Finally, we discuss some challenges yet to be addressed in the use of semi-supervised models for modeling human categorization. Copyright © 2013 Cognitive Science Society, Inc.

  12. Universal microfluidic automaton for autonomous sample processing: application to the Mars Organic Analyzer.

    PubMed

    Kim, Jungkyu; Jensen, Erik C; Stockton, Amanda M; Mathies, Richard A

    2013-08-20

    A fully integrated multilayer microfluidic chemical analyzer for automated sample processing and labeling, as well as analysis using capillary zone electrophoresis is developed and characterized. Using lifting gate microfluidic control valve technology, a microfluidic automaton consisting of a two-dimensional microvalve cellular array is fabricated with soft lithography in a format that enables facile integration with a microfluidic capillary electrophoresis device. The programmable sample processor performs precise mixing, metering, and routing operations that can be combined to achieve automation of complex and diverse assay protocols. Sample labeling protocols for amino acid, aldehyde/ketone and carboxylic acid analysis are performed automatically followed by automated transfer and analysis by the integrated microfluidic capillary electrophoresis chip. Equivalent performance to off-chip sample processing is demonstrated for each compound class; the automated analysis resulted in a limit of detection of ~16 nM for amino acids. Our microfluidic automaton provides a fully automated, portable microfluidic analysis system capable of autonomous analysis of diverse compound classes in challenging environments.

  13. Disentangling the Cosmic Web with Lagrangian Submanifold

    NASA Astrophysics Data System (ADS)

    Shandarin, Sergei F.; Medvedev, Mikhail V.

    2016-10-01

    The Cosmic Web is a complicated highly-entangled geometrical object. Remarkably it has formed from practically Gaussian initial conditions, which may be regarded as the simplest departure from exactly uniform universe in purely deterministic mapping. The full complexity of the web is revealed neither in configuration no velocity spaces considered separately. It can be fully appreciated only in six-dimensional (6D) phase space. However, studies of the phase space is complicated by the fact that every projection of it on a three-dimensional (3D) space is multivalued and contained caustics. In addition phase space is not a metric space that complicates studies of geometry. We suggest to use Lagrangian submanifold i.e., x = x(q), where both x and q are 3D vectors instead of the phase space for studies the complexity of cosmic web in cosmological N-body dark matter simulations. Being fully equivalent in dynamical sense to the phase space it has an advantage of being a single valued and also metric space.

  14. Electromechanical modeling of a honeycomb core integrated vibration energy converter with increased specific power for energy harvesting applications

    NASA Astrophysics Data System (ADS)

    Chandrasekharan, Nataraj

    Innovation in integrated circuit technology along with improved manufacturing processes has resulted in considerable reduction in power consumption of electromechanical devices. Majority of these devices are currently powered by batteries. However, the issues posed by batteries, including the need for frequent battery recharge/replacement has resulted in a compelling need for alternate energy to achieve self-sufficient device operation or to supplement battery power. Vibration based energy harvesting methods through piezoelectric transduction provides with a promising potential towards replacing or supplementing battery power source. However, current piezoelectric energy harvesters generate low specific power (power-to-weight ratio) when compared to batteries that the harvesters seek to replace or supplement. In this study, the potential of integrating lightweight cellular honeycomb structures with existing piezoelectric device configurations (bimorph) to achieve higher specific power is investigated. It is shown in this study that at low excitation frequency ranges, replacing the solid continuous substrate of a conventional piezoelectric bimorph with honeycomb structures of the same material results in a significant increase in power-to-weight ratio of the piezoelectric harvester. In order to maximize the electrical response of vibration based power harvesters, the natural frequency of these harvesters is designed to match the input driving frequency. The commonly used technique of adding a tip mass is employed to lower the natural frequency (to match driving frequency) of both, solid and honeycomb substrate bimorphs. At higher excitation frequency, the natural frequency of the traditional solid substrate bimorph can only be altered (to match driving frequency) through a change in global geometric design parameters, typically achieved by increasing the thickness of the harvester. As a result, the size of the harvester is increased and can be disadvantageous especially if the application imposes a space/size constraint. Moreover, the bimorph with increased thickness will now require a larger mechanical force to deform the structure which can fall outside the input ambient excitation amplitude range. In contrast, the honeycomb core bimorph offers an advantage in terms of preserving the global geometric dimensions. The natural frequency of the honeycomb core bimorph can be altered by manipulating honeycomb cell design parameters, such as cell angle, cell wall thickness, vertical cell height and inclined cell length. This results in a change in the mass and stiffness properties of the substrate and hence the bimorph, thereby altering the natural frequency of the harvester. Design flexibility of honeycomb core bimorphs is demonstrated by varying honeycomb cell parameters to alter mass and stiffness properties for power harvesting. The influence of honeycomb cell parameters on power generation is examined to evaluate optimum design to attain highest specific power. In addition, the more compliant nature of a honeycomb core bimorph decreases susceptibility towards fatigue and can increase the operating lifetime of the harvester. The second component of this dissertation analyses an uncoupled equivalent circuit model for piezoelectric energy harvesting. Open circuit voltage developed on the piezoelectric materials can be easily computed either through analytical or finite element models. The efficacy of a method to determine power developed across a resistive load, by representing the coupled piezoelectric electromechanical problem with an external load as an open circuit voltage driven equivalent circuit, is evaluated. The lack of backward feedback at finite resistive loads resulting from such an equivalent representation is examined by comparing the equivalent circuit model to the governing equations of a fully coupled circuit model for the electromechanical problem. It is found that the backward feedback is insignificant for weakly coupled systems typically seen in micro electromechanical systems and other energy harvesting device configurations with low coupling. For moderate to high coupling systems, a correction factor based on a calibrated resistance is presented which can be used to evaluate power generation at a specific resistive load.

  15. One-loop topological expansion for spin glasses in the large connectivity limit

    NASA Astrophysics Data System (ADS)

    Chiara Angelini, Maria; Parisi, Giorgio; Ricci-Tersenghi, Federico

    2018-01-01

    We apply for the first time a new one-loop topological expansion around the Bethe solution to the spin-glass model with a field in the high connectivity limit, following the methodological scheme proposed in a recent work. The results are completely equivalent to the well-known ones, found by standard field-theoretical expansion around the fully connected model (Bray and Roberts 1980, and following works). However this method has the advantage that the starting point is the original Hamiltonian of the model, with no need to define an associated field theory, nor to know the initial values of the couplings, and the computations have a clear and simple physical meaning. Moreover this new method can also be applied in the case of zero temperature, when the Bethe model has a transition in field, contrary to the fully connected model that is always in the spin-glass phase. Sharing with finite-dimensional model the finite connectivity properties, the Bethe lattice is clearly a better starting point for an expansion with respect to the fully connected model. The present work is a first step towards the generalization of this new expansion to more difficult and interesting cases as the zero-temperature limit, where the expansion could lead to different results with respect to the standard one.

  16. Method for modeling the gradual physical degradation of a porous material

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Flach, Greg

    Cementitious and other engineered porous materials encountered in waste disposals may degrade over time due to one or more mechanisms. Physical degradation may take the form of cracking (fracturing) and/or altered (e.g. increased) porosity, depending on the material and underlying degradation mechanism. In most cases, the hydraulic properties of degrading materials are expected to evolve due to physical changes occurring over roughly the pore to decimeter scale, which is conducive to calculating equivalent or effective material properties. The exact morphology of a degrading material in its end-state may or may not be known. In the latter case, the fully-degraded conditionmore » can be assumed to be similar to a more-permeable material in the surrounding environment, such as backfill soil. Then the fully-degraded waste form or barrier material is hydraulically neutral with respect to its surroundings, constituting neither a barrier to nor conduit for moisture flow and solute transport. Unless the degradation mechanism is abrupt, a gradual transition between the intact initial and fully-degraded final states is desired. Linear interpolation through time is one method for smoothly blending hydraulic properties between those of an intact matrix and those of a soil or other surrogate for the end-state.« less

  17. Hybrid graphene-copper UWB array sensor for brain tumor detection via scattering parameters in microwave detection system

    NASA Astrophysics Data System (ADS)

    Jamlos, Mohd Aminudin; Ismail, Abdul Hafiizh; Jamlos, Mohd Faizal; Narbudowicz, Adam

    2017-01-01

    Hybrid graphene-copper ultra-wideband array sensor applied to microwave imaging technique is successfully used in detecting and visualizing tumor inside human brain. The sensor made of graphene coated film for the patch while copper for both the transmission line and parasitic element. The hybrid sensor performance is better than fully copper sensor. Hybrid sensor recorded wider bandwidth of 2.0-10.1 GHz compared with fully copper sensor operated from 2.5 to 10.1 GHz. Higher gain of 3.8-8.5 dB is presented by hybrid sensor, while fully copper sensor stated lower gain ranging from 2.6 to 6.7 dB. Both sensors recorded excellent total efficiency averaged at 97 and 94%, respectively. The sensor used for both transmits equivalent signal and receives backscattering signal from stratified human head model in detecting tumor. Difference in the data of the scattering parameters recorded from the head model with presence and absence of tumor is used as the main data to be further processed in confocal microwave imaging algorithm in generating image. MATLAB software is utilized to analyze S-parameter signals obtained from measurement. Tumor presence is indicated by lower S-parameter values compared to higher values recorded by tumor absence.

  18. 4-S Positive Youth Development in Latin America: Professional Schools in Costa Rica

    ERIC Educational Resources Information Center

    Lopes, Sandro; Geldhof, G. John; Bowers, Edmond P.; Thogmartin, Asia

    2018-01-01

    As youth development programs established in the United States expand globally, researchers must evaluate their impacts in diverse contexts. The work described in this article established a baseline for assessing the impact of a 4-S youth program at professional technical high schools in Costa Rica. The 4-S program is equivalent to 4-H in…

  19. Global-local duality in eternal inflation

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Bousso, Raphael; Yang, I-S.

    2009-12-15

    We prove that the light-cone time cutoff on the multiverse defines the same probabilities as a causal patch with initial conditions in the longest-lived metastable vacuum. This establishes the equivalence of two measures of eternal inflation which naively appear very different (though both are motivated by holography). The duality can be traced to an underlying geometric relation which we identify.

  20. Communication—indentation of Li-ion pouch cell: Effect of material homogenization on prediction of internal short circuit

    DOE PAGES

    Kumar, A.; Kalnaus, Sergiy; Simunovic, Srdjan; ...

    2016-09-12

    We performed finite element simulations of spherical indentation of Li-ion pouch cells. Our model fully resolves different layers in the cell. The results of the layer resolved models were compared to the models available in the literature that treat the cell as an equivalent homogenized continuum material. Simulations were carried out for different sizes of the spherical indenter. Here, we show that calibration of a failure criterion for the cell in the homogenized model depends on the indenter size, whereas in the layer-resoled model, such dependency is greatly diminished.

  1. Impaired functioning of immune defenses to infection in premature and term infants and their implications for vaccination.

    PubMed

    Baxter, David

    2010-06-01

    Newborn infants, particularly those born prematurely are at increased risk of infections, including vaccine preventable ones, resulting in an increased morbidity and mortality risk. Defects associated with higher mortality may involve external barriers and the innate and adaptive systems. The available evidence suggests a complex situation that ranges from pathogen/immunogen non-responsiveness to fully mature adult-equivalent functionality depending on both host and vaccine characteristics. This review considers potential qualitative and quantitative differences with respect to immune defences between premature/term infants and adults and evaluates implications of such differences for immunization outcomes.

  2. CONCEPTUAL BASIS FOR NATURAL ATTENUATION (NA) ...

    EPA Pesticide Factsheets

    As used in enforcement actions at hazardous waste sites by U.S. EPA, monitored natural attenuation is a remedy fully equivalent to any other remedy. The acceptance of MNA is based on three lines of evidence: historical ground water and/or soil chemistry data that demonstrates a trend of declining contaminant concentration, 2. hydrogeologic and geochemical data that demonstrate NA processes and rates, and 3. Field or microcosm studies. MNA is appropriate as remedial approach only where it can be demonstrated to achieve remedial objectives within reasonable time frame, and meets the applicable remedy selection criteria for the particular regulatory program. To inform the public.

  3. 3.0 Tesla magnetic resonance imaging: A new standard in liver imaging?

    PubMed Central

    Girometti, Rossano

    2015-01-01

    An ever-increasing number of 3.0 Tesla (T) magnets are installed worldwide. Moving from the standard of 1.5 T to higher field strength implies a number of potential advantage and drawbacks, requiring careful optimization of imaging protocols or implementation of novel hardware components. Clinical practice and literature review suggest that state-of-the-art 3.0 T is equivalent to 1.5 T in the assessment of focal liver lesions and diffuse liver disease. Therefore, further technical improvements are needed in order to fully exploit the potential of higher field strength. PMID:26244063

  4. 3.0 Tesla magnetic resonance imaging: A new standard in liver imaging?

    PubMed

    Girometti, Rossano

    2015-07-28

    An ever-increasing number of 3.0 Tesla (T) magnets are installed worldwide. Moving from the standard of 1.5 T to higher field strength implies a number of potential advantage and drawbacks, requiring careful optimization of imaging protocols or implementation of novel hardware components. Clinical practice and literature review suggest that state-of-the-art 3.0 T is equivalent to 1.5 T in the assessment of focal liver lesions and diffuse liver disease. Therefore, further technical improvements are needed in order to fully exploit the potential of higher field strength.

  5. Modular microfluidic valve structures based on reversible thermoresponsive ionogel actuators.

    PubMed

    Benito-Lopez, Fernando; Antoñana-Díez, Marta; Curto, Vincenzo F; Diamond, Dermot; Castro-López, Vanessa

    2014-09-21

    This paper reports for the first time the use of a cross-linked poly(N-isopropylacrylamide) ionogel encapsulating the ionic liquid 1-ethyl-3-methylimidazolium ethyl sulphate as a thermoresponsive and modular microfluidic valve. The ionogel presents superior actuation behaviour to its equivalent hydrogel. Ionogel swelling and shrinking mechanisms and kinetics are investigated as well as the performance of the ionogel when integrated as a valve in a microfluidic device. The modular microfluidic valve demonstrates fully a reversible on-off behaviour without failure for up to eight actuation cycles and a pressure resistance of 1100 mbar.

  6. Fully Coupled Thermomechanical Finite Element Analysis of Material Evolution During Friction-Stir Welding of AA5083

    DTIC Science & Technology

    2009-09-03

    coefficients are set to a value of 0.3. The stick/slip critical shear stress level is defined using a modified Coulomb friction law. Within this law, there...Modified Johnson Cook Model Equivalent Plastic Strain a P M,htgnert S d lei Y 1 2 3 4 5 6 7 420 440 460 480 500 520 540 560 Original Johnson Cook Model...Lett., 2005, 59, 3315–3318. 7 Thomas, W. M. and Nicholas, E. D. Friction stir welding for the transportation industries. Mater. Des ., 1997, 18, 269

  7. Generating polarization-entangled photon pairs using cross-spliced birefringent fibers.

    PubMed

    Meyer-Scott, Evan; Roy, Vincent; Bourgoin, Jean-Philippe; Higgins, Brendon L; Shalm, Lynden K; Jennewein, Thomas

    2013-03-11

    We demonstrate a novel polarization-entangled photon-pair source based on standard birefringent polarization-maintaining optical fiber. The source consists of two stretches of fiber spliced together with perpendicular polarization axes, and has the potential to be fully fiber-based, with all bulk optics replaced with in-fiber equivalents. By modelling the temporal walk-off in the fibers, we implement compensation necessary for the photon creation processes in the two stretches of fiber to be indistinguishable. Our source subsequently produces a high quality entangled state having (92.2 ± 0.2) % fidelity with a maximally entangled Bell state.

  8. Effect of Damping and Yielding on the Seismic Response of 3D Steel Buildings with PMRF

    PubMed Central

    Haldar, Achintya; Rodelo-López, Ramon Eduardo; Bojórquez, Eden

    2014-01-01

    The effect of viscous damping and yielding, on the reduction of the seismic responses of steel buildings modeled as three-dimensional (3D) complex multidegree of freedom (MDOF) systems, is studied. The reduction produced by damping may be larger or smaller than that of yielding. This reduction can significantly vary from one structural idealization to another and is smaller for global than for local response parameters, which in turn depends on the particular local response parameter. The uncertainty in the estimation is significantly larger for local response parameter and decreases as damping increases. The results show the limitations of the commonly used static equivalent lateral force procedure where local and global response parameters are reduced in the same proportion. It is concluded that estimating the effect of damping and yielding on the seismic response of steel buildings by using simplified models may be a very crude approximation. Moreover, the effect of yielding should be explicitly calculated by using complex 3D MDOF models instead of estimating it in terms of equivalent viscous damping. The findings of this paper are for the particular models used in the study. Much more research is needed to reach more general conclusions. PMID:25097892

  9. Energy Finite Element Analysis Developments for Vibration Analysis of Composite Aircraft Structures

    NASA Technical Reports Server (NTRS)

    Vlahopoulos, Nickolas; Schiller, Noah H.

    2011-01-01

    The Energy Finite Element Analysis (EFEA) has been utilized successfully for modeling complex structural-acoustic systems with isotropic structural material properties. In this paper, a formulation for modeling structures made out of composite materials is presented. An approach based on spectral finite element analysis is utilized first for developing the equivalent material properties for the composite material. These equivalent properties are employed in the EFEA governing differential equations for representing the composite materials and deriving the element level matrices. The power transmission characteristics at connections between members made out of non-isotropic composite material are considered for deriving suitable power transmission coefficients at junctions of interconnected members. These coefficients are utilized for computing the joint matrix that is needed to assemble the global system of EFEA equations. The global system of EFEA equations is solved numerically and the vibration levels within the entire system can be computed. The new EFEA formulation for modeling composite laminate structures is validated through comparison to test data collected from a representative composite aircraft fuselage that is made out of a composite outer shell and composite frames and stiffeners. NASA Langley constructed the composite cylinder and conducted the test measurements utilized in this work.

  10. Effect of damping and yielding on the seismic response of 3D steel buildings with PMRF.

    PubMed

    Reyes-Salazar, Alfredo; Haldar, Achintya; Rodelo-López, Ramon Eduardo; Bojórquez, Eden

    2014-01-01

    The effect of viscous damping and yielding, on the reduction of the seismic responses of steel buildings modeled as three-dimensional (3D) complex multidegree of freedom (MDOF) systems, is studied. The reduction produced by damping may be larger or smaller than that of yielding. This reduction can significantly vary from one structural idealization to another and is smaller for global than for local response parameters, which in turn depends on the particular local response parameter. The uncertainty in the estimation is significantly larger for local response parameter and decreases as damping increases. The results show the limitations of the commonly used static equivalent lateral force procedure where local and global response parameters are reduced in the same proportion. It is concluded that estimating the effect of damping and yielding on the seismic response of steel buildings by using simplified models may be a very crude approximation. Moreover, the effect of yielding should be explicitly calculated by using complex 3D MDOF models instead of estimating it in terms of equivalent viscous damping. The findings of this paper are for the particular models used in the study. Much more research is needed to reach more general conclusions.

  11. Comparison of Fully Automated Computer Analysis and Visual Scoring for Detection of Coronary Artery Disease from Myocardial Perfusion SPECT in a Large Population

    PubMed Central

    Arsanjani, Reza; Xu, Yuan; Hayes, Sean W.; Fish, Mathews; Lemley, Mark; Gerlach, James; Dorbala, Sharmila; Berman, Daniel S.; Germano, Guido; Slomka, Piotr

    2012-01-01

    We compared the performance of a fully automated quantification of attenuation-corrected (AC) and non-corrected (NC) myocardial perfusion single photon emission computed tomography (MPS) with the corresponding performance of experienced readers for the detection coronary artery disease (CAD). Methods 995 rest/stress 99mTc-sestamibi MPS studies, [650 consecutive cases with coronary angiography and 345 with likelihood of CAD < 5% (LLk)] were obtained by MPS with AC. Total perfusion deficit (TPD) for AC and NC data were compared to the visual summed stress and rest scores of 2 experienced readers. Visual reads were performed in 4 consecutive steps with the following information progressively revealed: NC data, AC+NC data, computer results, all clinical information. Results The diagnostic accuracy of TPD for detection of CAD was similar to both readers (NC: 82% vs. 84%, AC: 86% vs. 85–87% p = NS) with the exception of second reader when using clinical information (89%, p < 0.05). The Receiver-Operator-Characteristics Areas-Under-Curve (ROC-AUC) for TPD were significantly better than visual reads for NC (0.91 vs. 0.87 and 0.89, p < 0.01) and AC (0.92 vs. 0.90, p < 0.01), and it was comparable to visual reads incorporating all clinical information. Per-vessel accuracy of TPD was superior to one reader for NC (81% vs. 77%, p < 0.05) and AC (83% vs. 78%, p < 0.05) and equivalent to second reader [NC (79%) and AC (81%)]. Per-vessel ROC-AUC for NC (0.83) and AC (0.84) for TPD were better than (0.78–0.80 p < 0.01), and comparable to second reader (0.82–0.84, p = NS), for all steps. Conclusion For the detection of ≥ 70% stenosis based on angiographic criteria, a fully automated computer analysis of NC and AC MPS data is equivalent for per-patient and can be superior for per-vessel analysis, when compared to expert analysis. PMID:23315665

  12. Satellite Snow-Cover Mapping: A Brief Review

    NASA Technical Reports Server (NTRS)

    Hall, Dorothy K.

    1995-01-01

    Satellite snow mapping has been accomplished since 1966, initially using data from the reflective part of the electromagnetic spectrum, and now also employing data from the microwave part of the spectrum. Visible and near-infrared sensors can provide excellent spatial resolution from space enabling detailed snow mapping. When digital elevation models are also used, snow mapping can provide realistic measurements of snow extent even in mountainous areas. Passive-microwave satellite data permit global snow cover to be mapped on a near-daily basis and estimates of snow depth to be made, but with relatively poor spatial resolution (approximately 25 km). Dense forest cover limits both techniques and optical remote sensing is limited further by cloudcover conditions. Satellite remote sensing of snow cover with imaging radars is still in the early stages of research, but shows promise at least for mapping wet or melting snow using C-band (5.3 GHz) synthetic aperture radar (SAR) data. Observing System (EOS) Moderate Resolution Imaging Spectroradiometer (MODIS) data beginning with the launch of the first EOS platform in 1998. Digital maps will be produced that will provide daily, and maximum weekly global snow, sea ice and lake ice cover at 1-km spatial resolution. Statistics will be generated on the extent and persistence of snow or ice cover in each pixel for each weekly map, cloudcover permitting. It will also be possible to generate snow- and ice-cover maps using MODIS data at 250- and 500-m resolution, and to study and map snow and ice characteristics such as albedo. been under development. Passive-microwave data offer the potential for determining not only snow cover, but snow water equivalent, depth and wetness under all sky conditions. A number of algorithms have been developed to utilize passive-microwave brightness temperatures to provide information on snow cover and water equivalent. The variability of vegetative Algorithms are being developed to map global snow and ice cover using Earth Algorithms to map global snow cover using passive-microwave data have also cover and of snow grain size, globally, limits the utility of a single algorithm to map global snow cover.

  13. Emergence of the global research alliance on agricultural greenhouse gases

    USDA-ARS?s Scientific Manuscript database

    Increasing human population pressure on the Earth is of great concern and a key reason why agricultural and natural resource sciences must be fully engaged to develop solutions for a sustainable future. Increasing population puts pressure on the demand for food, clean water, healthy soil, and a sta...

  14. Effects of Country and Delivery Mode on Perceived Risk in International Higher Education

    ERIC Educational Resources Information Center

    Kamal Basha, Norazlyn; Sweeney, Jillian C.; Soutar, Geoff

    2015-01-01

    Higher education is an increasingly competitive global market. Consequently, it is crucial that universities fully understand students' motivations in university selection. While past research mainly focused on university-level attributes, this study extends the factors used to evaluate different international universities to include both the…

  15. 75 FR 2181 - Bureau of Educational and Cultural Affairs (ECA) Request for Grant Proposals: Global...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-14

    ... Solicitation Package for further information. IV.3d.2 Diversity, Freedom and Democracy Guidelines: Pursuant to... ethnicity, race, gender, religion, geographic location, socio-economic status, and physical challenges... whose people do not fully enjoy freedom and democracy,'' the Bureau ``shall take appropriate steps to...

  16. Evaluation Systems, Ethics, and Development Evaluation

    ERIC Educational Resources Information Center

    Thomas, Vinod

    2010-01-01

    After some 65 years of international development assistance, it is still difficult to show the effectiveness of aid in ways that are fully convincing. In part, this reflects inadequacies in the evaluation systems of the bilateral, multilateral, and global organizations that provide official development aid. Underlying these weaknesses often are a…

  17. Differential Outcomes in Agency-Based Mental Health Care between Minority and Majority Youth

    ERIC Educational Resources Information Center

    Patterson, David A.; Dulmus, Catherine N.; Maguin, Eugene; Perkins, Jacob

    2016-01-01

    Background: Childhood mental health problems represent a significant public health concern globally. There is a converging discussion among researchers and practitioners alike that the research results of effectiveness studies are not fully generalizable and applicable to ethnoracial minority groups in real-world practice settings. Methods:…

  18. Comparison of perfluorooctanoic acid mobility in soil with and without alfalfa

    USDA-ARS?s Scientific Manuscript database

    Perfluorooctanoic acid (PFOA) is a fully fluorinated organic compound (C8HF15O2) that is widely used in consumer products as a surfactant because of its chemical resistance to stains, grease, and water. Perfluorooctanoic acid is a persistent organic pollutant because it is globally distributed, stab...

  19. Improved treatment of global positioning system force parameters in precise orbit determination applications

    NASA Technical Reports Server (NTRS)

    Vigue, Y.; Lichten, S. M.; Muellerschoen, R. J.; Blewitt, G.; Heflin, M. B.

    1993-01-01

    Data collected from a worldwide 1992 experiment were processed at JPL to determine precise orbits for the satellites of the Global Positioning System (GPS). A filtering technique was tested to improve modeling of solar-radiation pressure force parameters for GPS satellites. The new approach improves orbit quality for eclipsing satellites by a factor of two, with typical results in the 25- to 50-cm range. The resultant GPS-based estimates for geocentric coordinates of the tracking sites, which include the three DSN sites, are accurate to 2 to 8 cm, roughly equivalent to 3 to 10 nrad of angular measure.

  20. Author Correction: Global patterns in mangrove soil carbon stocks and losses

    NASA Astrophysics Data System (ADS)

    Atwood, Trisha B.; Connolly, Rod M.; Almahasheer, Hanan; Carnell, Paul E.; Duarte, Carlos M.; Lewis, Carolyn J. Ewers; Irigoien, Xabier; Kelleway, Jeffrey J.; Lavery, Paul S.; Macreadie, Peter I.; Serrano, Oscar; Sanders, Christian J.; Santos, Isaac; Steven, Andrew D. L.; Lovelock, Catherine E.

    2018-03-01

    In the version of this Article originally published, the potential carbon loss from soils as a result of mangrove deforestation was incorrectly given as `2.0-75 Tg C yr-1'; this should have read `2-8 Tg C yr-1'. The corresponding emissions were incorrectly given as ` 7.3-275 Tg of CO2e'; this should have read ` 7-29 Tg of CO2e'. The corresponding percentage equivalent of these emissions compared with those from global terrestrial deforestation was incorrectly given as `0.2-6%'; this should have read `0.6-2.4%'. These errors have now been corrected in all versions of the Article.

  1. Combustion of Gaseous Fuels with High Temperature Air in Normal- and Micro-gravity Conditions

    NASA Technical Reports Server (NTRS)

    Wang, Y.; Gupta, A. K.

    2001-01-01

    The objective of this study is determine the effect of air preheat temperature on flame characteristics in normal and microgravity conditions. We have obtained qualitative (global flame features) and some quantitative information on the features of flames using high temperature combustion air under normal gravity conditions with propane and methane as the fuels. This data will be compared with the data under microgravity conditions. The specific focus under normal gravity conditions has been on determining the global flame features as well as the spatial distribution of OH, CH, and C2 from flames using high temperature combustion air at different equivalence ratio.

  2. Nonlinear static and dynamic analysis of beam structures using fully intrinsic equations

    NASA Astrophysics Data System (ADS)

    Sotoudeh, Zahra

    2011-07-01

    Beams are structural members with one dimension much larger than the other two. Examples of beams include propeller blades, helicopter rotor blades, and high aspect-ratio aircraft wings in aerospace engineering; shafts and wind turbine blades in mechanical engineering; towers, highways and bridges in civil engineering; and DNA modeling in biomedical engineering. Beam analysis includes two sets of equations: a generally linear two-dimensional problem over the cross-sectional plane and a nonlinear, global one-dimensional analysis. This research work deals with a relatively new set of equations for one-dimensional beam analysis, namely the so-called fully intrinsic equations. Fully intrinsic equations comprise a set of geometrically exact, nonlinear, first-order partial differential equations that is suitable for analyzing initially curved and twisted anisotropic beams. A fully intrinsic formulation is devoid of displacement and rotation variables, making it especially attractive because of the absence of singularities, infinite-degree nonlinearities, and other undesirable features associated with finite rotation variables. In spite of the advantages of these equations, using them with certain boundary conditions presents significant challenges. This research work will take a broad look at these challenges of modeling various boundary conditions when using the fully intrinsic equations. Hopefully it will clear the path for wider and easier use of the fully intrinsic equations in future research. This work also includes application of fully intrinsic equations in structural analysis of joined-wing aircraft, different rotor blade configuration and LCO analysis of HALE aircraft.

  3. [Cross-cultural adaptation and validation of the PROMIS Global Health scale in the Portuguese language].

    PubMed

    Zumpano, Camila Eugênia; Mendonça, Tânia Maria da Silva; Silva, Carlos Henrique Martins da; Correia, Helena; Arnold, Benjamin; Pinto, Rogério de Melo Costa

    2017-01-23

    This study aimed to perform the cross-cultural adaptation and validation of the Patient-Reported Outcomes Measurement Information System (PROMIS) Global Health scale in the Portuguese language. The ten Global Health items were cross-culturally adapted by the method proposed in the Functional Assessment of Chronic Illness Therapy (FACIT). The instrument's final version in Portuguese was self-administered by 1,010 participants in Brazil. The scale's precision was verified by floor and ceiling effects analysis, reliability of internal consistency, and test-retest reliability. Exploratory and confirmatory factor analyses were used to assess the construct's validity and instrument's dimensionality. Calibration of the items used the Gradual Response Model proposed by Samejima. Four global items required adjustments after the pretest. Analysis of the psychometric properties showed that the Global Health scale has good reliability, with Cronbach's alpha of 0.83 and intra-class correlation of 0.89. Exploratory and confirmatory factor analyses showed good fit in the previously established two-dimensional model. The Global Physical Health and Global Mental Health scale showed good latent trait coverage according to the Gradual Response Model. The PROMIS Global Health items showed equivalence in Portuguese compared to the original version and satisfactory psychometric properties for application in clinical practice and research in the Brazilian population.

  4. MUTZ-3 derived Langerhans cells in human skin equivalents show differential migration and phenotypic plasticity after allergen or irritant exposure

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kosten, Ilona J.; Spiekstra, Sander W.; Gruijl, Tanja D. de

    After allergen or irritant exposure, Langerhans cells (LC) undergo phenotypic changes and exit the epidermis. In this study we describe the unique ability of MUTZ-3 derived Langerhans cells (MUTZ-LC) to display similar phenotypic plasticity as their primary counterparts when incorporated into a physiologically relevant full-thickness skin equivalent model (SE-LC). We describe differences and similarities in the mechanisms regulating LC migration and plasticity upon allergen or irritant exposure. The skin equivalent consisted of a reconstructed epidermis containing primary differentiated keratinocytes and CD1a{sup +} MUTZ-LC on a primary fibroblast-populated dermis. Skin equivalents were exposed to a panel of allergens and irritants. Topicalmore » exposure to sub-toxic concentrations of allergens (nickel sulfate, resorcinol, cinnamaldehyde) and irritants (Triton X-100, SDS, Tween 80) resulted in LC migration out of the epidermis and into the dermis. Neutralizing antibody to CXCL12 blocked allergen-induced migration, whereas anti-CCL5 blocked irritant-induced migration. In contrast to allergen exposure, irritant exposure resulted in cells within the dermis becoming CD1a{sup −}/CD14{sup +}/CD68{sup +} which is characteristic of a phenotypic switch of MUTZ-LC to a macrophage-like cell in the dermis. This phenotypic switch was blocked with anti-IL-10. Mechanisms previously identified as being involved in LC activation and migration in native human skin could thus be reproduced in the in vitro constructed skin equivalent model containing functional LC. This model therefore provides a unique and relevant research tool to study human LC biology in situ under controlled in vitro conditions, and will provide a powerful tool for hazard identification, testing novel therapeutics and identifying new drug targets. - Highlights: • MUTZ-3 derived Langerhans cells integrated into skin equivalents are fully functional. • Anti-CXCL12 blocks allergen-induced MUTZ-LC migration. • Anti-CCL5 blocks irritant-induced MUTZ-LC migration. • Irritant mediated MUTZ-LC trans-differentiation to macrophage-like cell in dermis. • Trans-differentiation of MUTZ-LC is IL-10 dependent.« less

  5. Fluoroscopy and imageless navigation enable an equivalent reconstruction of leg length and global and femoral offset in THA.

    PubMed

    Weber, Markus; Woerner, Michael; Springorum, Robert; Sendtner, Ernst; Hapfelmeier, Alexander; Grifka, Joachim; Renkawitz, Tobias

    2014-10-01

    Restoration of biomechanics is a major goal in THA. Imageless navigation enables intraoperative control of leg length equalization and offset reconstruction. However, the effect of navigation compared with intraoperative fluoroscopy is unclear. We asked whether intraoperative use of imageless navigation (1) improves the relative accuracy of leg length and global and femoral offset restoration; (2) increases the absolute precision of leg length and global and femoral offset equalization; and (3) reduces outliers in a reconstruction zone of ± 5 mm for leg length and global and femoral offset restoration compared with intraoperative fluoroscopy during minimally invasive (MIS) THA with the patient in a lateral decubitus position. In this prospective study a consecutive series of 125 patients were randomized to either navigation-guided or fluoroscopy-controlled THA using sealed, opaque envelopes. All patients received the same cementless prosthetic components through an anterolateral MIS approach while they were in a lateral decubitus position. Leg length, global or total offset (representing the combination of femoral and acetabular offset), and femoral offset differences were restored using either navigation or fluoroscopy. Postoperatively, residual leg length and global and femoral offset discrepancies were analyzed on magnification-corrected radiographs of the pelvis by an independent and blinded examiner using digital planning software. Accuracy was defined as the relative postoperative difference between the surgically treated and the unaffected contralateral side for leg length and offset, respectively; precision was defined as the absolute postoperative deviation of leg length and global and femoral offset regardless of lengthening or shortening of leg length and offset throughout the THA. All analyses were performed per intention-to-treat. Analyzing the relative accuracy of leg length restoration we found a mean difference of 0.2 mm (95% CI, -1.0 to +1.4 mm; p = 0.729) between fluoroscopy and navigation, 0.2 mm (95 % CI, -0.9 to +1.3 mm; p = 0.740) for global offset and 1.7 mm (95 % CI, +0.4 to +2.9 mm; p = 0.008) for femoral offset. For the absolute precision of leg length and global and femoral offset equalization, there was a mean difference of 1.7 ± 0.3 mm (p < 0.001) between fluoroscopy and navigation. The biomechanical reconstruction with a residual leg length and global and femoral offset discrepancy less than 5 mm and less than 8 mm, respectively, succeeded in 93% and 98%, respectively, in the navigation group and in 54% and 95%, respectively, in the fluoroscopy group. Intraoperative fluoroscopy and imageless navigation seem equivalent in accuracy and precision to reconstruct leg length and global and femoral offset during MIS THA with the patient in the lateral decubitus position.

  6. Equivalence of the EMD- and NEMD-based decomposition of thermal conductivity into microscopic building blocks.

    PubMed

    Matsubara, Hiroki; Kikugawa, Gota; Ishikiriyama, Mamoru; Yamashita, Seiji; Ohara, Taku

    2017-09-21

    Thermal conductivity of a material can be comprehended as being composed of microscopic building blocks relevant to the energy transfer due to a specific microscopic process or structure. The building block is called the partial thermal conductivity (PTC). The concept of PTC is essential to evaluate the contributions of various molecular mechanisms to heat conduction and has been providing detailed knowledge of the contribution. The PTC can be evaluated by equilibrium molecular dynamics (EMD) and non-equilibrium molecular dynamics (NEMD) in different manners: the EMD evaluation utilizes the autocorrelation of spontaneous heat fluxes in an equilibrium state whereas the NEMD one is based on stationary heat fluxes in a non-equilibrium state. However, it has not been fully discussed whether the two methods give the same PTC or not. In the present study, we formulate a Green-Kubo relation, which is necessary for EMD to calculate the PTCs equivalent to those by NEMD. Unlike the existing theories, our formulation is based on the local equilibrium hypothesis to describe a clear connection between EMD and NEMD simulations. The equivalence of the two derivations of PTCs is confirmed by the numerical results for liquid methane and butane. The present establishment of the EMD-NEMD correspondence makes the MD analysis of PTCs a robust way to clarify the microscopic origins of thermal conductivity.

  7. Influence of Th2 Cytokines on the Cornified Envelope, Tight Junction Proteins, and ß-Defensins in Filaggrin-Deficient Skin Equivalents.

    PubMed

    Hönzke, Stefan; Wallmeyer, Leonie; Ostrowski, Anja; Radbruch, Moritz; Mundhenk, Lars; Schäfer-Korting, Monika; Hedtrich, Sarah

    2016-03-01

    Atopic dermatitis is a chronic skin condition with complex etiology. It is characterized by skin barrier defects and T helper type 2 (Th2)-polarized inflammation. Although mutations in the filaggrin gene are known to be prominent genetic risk factors for the development of atopic dermatitis, the interdependency between these and an altered cytokine milieu is not fully understood. In this study, we evaluated the direct effects of filaggrin deficiency on the cornified envelope, tight junction proteins, and innate immune response, and report the effects of Th2 cytokines in normal and filaggrin-deficient skin equivalents. Supplementation with IL-4 and IL-13 led to distinct histologic changes and significantly increased skin surface pH, both of which were enhanced in filaggrin knockdown skin equivalents. We detected a compensatory up-regulation of involucrin and occludin in filaggrin-deficient skin that was dramatically disturbed when simultaneous inflammation occurred. Furthermore, we found that a lack of filaggrin triggered an up-regulation of human ?-defensin 2 via an unknown mechanism, which was abolished by Th2 cytokine supplementation. Taken together, these results indicate that defects in the epidermal barrier, skin permeability, and cutaneous innate immune response are not primarily linked to filaggrin deficiency but are rather secondarily induced by Th2 inflammation. Copyright © 2015 The Authors. Published by Elsevier Inc. All rights reserved.

  8. On the local well-posedness and a Prodi-Serrin-type regularity criterion of the three-dimensional MHD-Boussinesq system without thermal diffusion

    NASA Astrophysics Data System (ADS)

    Larios, Adam; Pei, Yuan

    2017-07-01

    We prove a Prodi-Serrin-type global regularity condition for the three-dimensional Magnetohydrodynamic-Boussinesq system (3D MHD-Boussinesq) without thermal diffusion, in terms of only two velocity and two magnetic components. To the best of our knowledge, this is the first Prodi-Serrin-type criterion for such a 3D hydrodynamic system which is not fully dissipative, and indicates that such an approach may be successful on other systems. In addition, we provide a constructive proof of the local well-posedness of solutions to the fully dissipative 3D MHD-Boussinesq system, and also the fully inviscid, irresistive, non-diffusive MHD-Boussinesq equations. We note that, as a special case, these results include the 3D non-diffusive Boussinesq system and the 3D MHD equations. Moreover, they can be extended without difficulty to include the case of a Coriolis rotational term.

  9. Fully implicit Particle-in-cell algorithms for multiscale plasma simulation

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Chacon, Luis

    The outline of the paper is as follows: Particle-in-cell (PIC) methods for fully ionized collisionless plasmas, explicit vs. implicit PIC, 1D ES implicit PIC (charge and energy conservation, moment-based acceleration), and generalization to Multi-D EM PIC: Vlasov-Darwin model (review and motivation for Darwin model, conservation properties (energy, charge, and canonical momenta), and numerical benchmarks). The author demonstrates a fully implicit, fully nonlinear, multidimensional PIC formulation that features exact local charge conservation (via a novel particle mover strategy), exact global energy conservation (no particle self-heating or self-cooling), adaptive particle orbit integrator to control errors in momentum conservation, and canonical momenta (EM-PICmore » only, reduced dimensionality). The approach is free of numerical instabilities: ω peΔt >> 1, and Δx >> λ D. It requires many fewer dofs (vs. explicit PIC) for comparable accuracy in challenging problems. Significant CPU gains (vs explicit PIC) have been demonstrated. The method has much potential for efficiency gains vs. explicit in long-time-scale applications. Moment-based acceleration is effective in minimizing N FE, leading to an optimal algorithm.« less

  10. Integrated assessment of global water scarcity over the 21st century under multiple climate change mitigation policies

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Hejazi, Mohamad I.; Edmonds, James A.; Clarke, Leon E.

    2014-08-01

    Water scarcity conditions over the 21st century both globally and regionally are assessed in the context of climate change and climate mitigation policies, by estimating both water availability and water demand within the Global Change Assessment Model (GCAM), a leading community integrated assessment model of energy, agriculture, climate, and water. To quantify changes in future water availability, a new gridded water-balance global hydrologic model – namely, the Global Water Availability Model (GWAM) – is developed and evaluated. Global water demands for six major demand sectors (irrigation, livestock, domestic, electricity generation, primary energy production, and manufacturing) are modeled in GCAM atmore » the regional scale (14 geopolitical regions, 151 sub-regions) and then spatially downscaled to 0.5 o x 0.5o resolution to match the scale of GWAM. Using a baseline scenario (i.e., no climate change mitigation policy) with radiative forcing reaching 8.8 W/m2 (equivalent to the SRES A1Fi emission scenario) and three climate policy scenarios with increasing mitigation stringency of 7.7, 5.5, and 4.2 W/m2 (equivalent to the SRES A2, B2, and B1 emission scenarios, respectively), we investigate the effects of emission mitigation policies on water scarcity. Two carbon tax regimes (a universal carbon tax (UCT) which includes land use change emissions, and a fossil fuel and industrial emissions carbon tax (FFICT) which excludes land use change emissions) are analyzed. The baseline scenario results in more than half of the world population living under extreme water scarcity by the end of the 21st century. Additionally, in years 2050 and 2095, 36% (28%) and 44% (39%) of the global population, respectively, is projected to live in grid cells (in basins) that will experience greater water demands than the amount of available water in a year (i.e., the water scarcity index (WSI) > 1.0). When comparing the climate policy scenarios to the baseline scenario while maintaining the same baseline socioeconomic assumptions, water scarcity declines under a UCT mitigation policy but increases with a FFICT mitigation scenario by the year 2095 particularly with more stringent climate mitigation targets. Under the FFICT scenario, water scarcity is projected to increase driven by higher water demands for bio-energy crops.« less

  11. Integrated assessment of global water scarcity over the 21st century under multiple climate change mitigation policies

    NASA Astrophysics Data System (ADS)

    Hejazi, M. I.; Edmonds, J.; Clarke, L.; Kyle, P.; Davies, E.; Chaturvedi, V.; Wise, M.; Patel, P.; Eom, J.; Calvin, K.

    2014-08-01

    Water scarcity conditions over the 21st century both globally and regionally are assessed in the context of climate change and climate mitigation policies, by estimating both water availability and water demand within the Global Change Assessment Model (GCAM), a leading community-integrated assessment model of energy, agriculture, climate, and water. To quantify changes in future water availability, a new gridded water-balance global hydrologic model - namely, the Global Water Availability Model (GWAM) - is developed and evaluated. Global water demands for six major demand sectors (irrigation, livestock, domestic, electricity generation, primary energy production, and manufacturing) are modeled in GCAM at the regional scale (14 geopolitical regions, 151 sub-regions) and then spatially downscaled to 0.5° × 0.5° resolution to match the scale of GWAM. Using a baseline scenario (i.e., no climate change mitigation policy) with radiative forcing reaching 8.8 W m-2 (equivalent to the SRES A1Fi emission scenario) and three climate policy scenarios with increasing mitigation stringency of 7.7, 5.5, and 4.2 W m-2 (equivalent to the SRES A2, B2, and B1 emission scenarios, respectively), we investigate the effects of emission mitigation policies on water scarcity. Two carbon tax regimes (a universal carbon tax (UCT) which includes land use change emissions, and a fossil fuel and industrial emissions carbon tax (FFICT) which excludes land use change emissions) are analyzed. The baseline scenario results in more than half of the world population living under extreme water scarcity by the end of the 21st century. Additionally, in years 2050 and 2095, 36% (28%) and 44% (39%) of the global population, respectively, is projected to live in grid cells (in basins) that will experience greater water demands than the amount of available water in a year (i.e., the water scarcity index (WSI) > 1.0). When comparing the climate policy scenarios to the baseline scenario while maintaining the same baseline socioeconomic assumptions, water scarcity declines under a UCT mitigation policy but increases with a FFICT mitigation scenario by the year 2095, particularly with more stringent climate mitigation targets. Under the FFICT scenario, water scarcity is projected to increase, driven by higher water demands for bio-energy crops.

  12. The trouble with 'Categories': Rethinking men who have sex with men, transgender and their equivalents in HIV prevention and health promotion.

    PubMed

    Parker, Richard; Aggleton, Peter; Perez-Brumer, Amaya G

    2016-01-01

    This double Special Issue of Global Public Health presents a collection of articles that seek more adequately to represent sexual and gender diversities and to begin to rethink the relationship to HIV prevention and health promotion - in both the resource rich nations of the global North, as well as in the more resource constrained nations of the global South. Reckoning with the reality that today the global response to HIV has failed to respond to the needs of gay, bisexual and other men who have sex with men, and transgender persons, we turn our attention to processes and practices of categorisation and classification, and the entanglement of the multiple social worlds that constitute our understanding of each of these categories and people within the categories. Jointly, these articles provide critical perspectives on how defining and redefining categories may impact the conceptual frameworks and empirical evidence that inform global understandings of HIV infection, those communities most vulnerable, and our collective response to the evolving HIV epidemic.

  13. High-Level ab initio electronic structure calculations of Water Clusters (H2O)16 and (H2O)17: a new global minimum for (H2O)16

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Yoo, Soohaeng; Apra, Edoardo; Zeng, Xiao Cheng

    The lowest-energy structures of water clusters (H2O)16 and (H2O)17 were revisited at the MP2 and CCSD(T) levels of theory. A new global minimum structure for (H2O)16 was found at the MP2 and CCSD(T) levels of theory and the effect of zero-point energy corrections on the relative stability of the low-lying minimum energy structures was assessed. For (H2O)17 the CCSD(T) calculations confirm the previously found at the MP2 level of theory "interior" arrangement (fully coordinated water molecule inside a spherical cluster) as the global minimum.

  14. High-Level ab-initio Electronic Structure Calculations of Water Clusters (H2O)16 and (H2O)17 : a New Global Minimum for (H2O)16

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Yoo, Soohaeng; Apra, Edoardo; Zeng, X.C.

    The lowest-energy structures of water clusters (H2O)16 and (H2O)17 were revisited at the MP2 and CCSD(T) levels of theory. A new global minimum structure for (H2O)16 was found at both the MP2 and CCSD(T) levels of theory, and the effect of zero-point energy corrections on the relative stability of the low-lying minimum energy structures was assessed. For (H2O)17, the CCSD(T) calculations confirm the previously found at the MP2 level of theory interior arrangement (fully coordinated water molecule inside a spherical cluster) as the global minimum

  15. GPS/GLONASS Time Transfer with 20-Channel Dual GNSS Receiver

    NASA Technical Reports Server (NTRS)

    Daly, P.; Riley, S.

    1996-01-01

    One of the world's two global navigation systems, the Global Positioning System (GPS), is already fully operational (April 1994) and the other, the Global Navigation Satellite System (GLONASS) will become operational by the end of 1995 or early 1996. Each will offer, independently of the other, precise location and time transfer continuously anywhere in the world and indeed in space itself. Many potential users, in particular the civil aviation community, are keenly interested in a joint GPS/GLONASS operation since it would offer substantial advantages in defining and maintaining the integrity of the navigation aid. Results are presented on the characterization of GPS/GLONASS time comparison using a 20-channel dual receiver developed and constructed at the University of Leeds, UK.

  16. Quantifying the Global Fresh Water Budget: Capabilities from Current and Future Satellite Sensors

    NASA Technical Reports Server (NTRS)

    Hildebrand, Peter; Zaitchik, Benjamin

    2007-01-01

    The global water cycle is complex and its components are difficult to measure, particularly at the global scales and with the precision needed for assessing climate impacts. Recent advances in satellite observational capabilities, however, are greatly improving our knowledge of the key terms in the fresh water flux budget. Many components of the of the global water budget, e.g. precipitation, atmospheric moisture profiles, soil moisture, snow cover, sea ice are now routinely measured globally using instruments on satellites such as TRMM, AQUA, TERRA, GRACE, and ICESat, as well as on operational satellites. New techniques, many using data assimilation approaches, are providing pathways toward measuring snow water equivalent, evapotranspiration, ground water, ice mass, as well as improving the measurement quality for other components of the global water budget. This paper evaluates these current and developing satellite capabilities to observe the global fresh water budget, then looks forward to evaluate the potential for improvements that may result from future space missions as detailed by the US Decadal Survey, and operational plans. Based on these analyses, and on the goal of improved knowledge of the global fresh water budget under the effects of climate change, we suggest some priorities for the future, based on new approaches that may provide the improved measurements and the analyses needed to understand and observe the potential speed-up of the global water cycle under the effects of climate change.

  17. Rapid, Fully Automated Digital Immunoassay for p24 Protein with the Sensitivity of Nucleic Acid Amplification for Detecting Acute HIV Infection.

    PubMed

    Cabrera, Carlos; Chang, Lei; Stone, Mars; Busch, Michael; Wilson, David H

    2015-11-01

    Nucleic acid testing (NAT) has become the standard for high sensitivity in detecting low levels of virus. However, adoption of NAT can be cost prohibitive in low-resource settings where access to extreme sensitivity could be clinically advantageous for early detection of infection. We report development and preliminary validation of a simple, low-cost, fully automated digital p24 antigen immunoassay with the sensitivity of quantitative NAT viral load (NAT-VL) methods for detection of acute HIV infection. We developed an investigational 69-min immunoassay for p24 capsid protein for use on a novel digital analyzer on the basis of single-molecule-array technology. We evaluated the assay for sensitivity by dilution of standardized preparations of p24, cultured HIV, and preseroconversion samples. We characterized analytical performance and concordance with 2 NAT-VL methods and 2 contemporary p24 Ag/Ab combination immunoassays with dilutions of viral isolates and samples from the earliest stages of HIV infection. Analytical sensitivity was 0.0025 ng/L p24, equivalent to 60 HIV RNA copies/mL. The limit of quantification was 0.0076 ng/L, and imprecision across 10 runs was <10% for samples as low as 0.09 ng/L. Clinical specificity was 95.1%. Sensitivity concordance vs NAT-VL on dilutions of preseroconversion samples and Group M viral isolates was 100%. The digital immunoassay exhibited >4000-fold greater sensitivity than contemporary immunoassays for p24 and sensitivity equivalent to that of NAT methods for early detection of HIV. The data indicate that NAT-level sensitivity for acute HIV infection is possible with a simple, low-cost digital immunoassay. © 2015 American Association for Clinical Chemistry.

  18. Effect of Maturity on Phenolics (Phenolic Acids and Flavonoids) Profile of Strawberry Cultivars and Mulberry Species from Pakistan

    PubMed Central

    Mahmood, Tahir; Anwar, Farooq; Abbas, Mateen; Saari, Nazamid

    2012-01-01

    In this study, we investigated how the extent of ripeness affects the yield of extract, total phenolics, total flavonoids, individual flavonols and phenolic acids in strawberry and mulberry cultivars from Pakistan. In strawberry, the yield of extract (%), total phenolics (TPC) and total flavonoids (TFC) ranged from 8.5–53.3%, 491–1884 mg gallic acid equivalents (GAE)/100 g DW and 83–327 mg catechin equivalents (CE)/100 g DW, respectively. For the different species of mulberry the yield of extract (%), total phenolics and total flavonoids of 6.9–54.0%, 201–2287 mg GAE/100 g DW and 110–1021 mg CE/100 g DW, respectively, varied significantly as fruit maturity progressed. The amounts of individual flavonols and phenolic acid in selected berry fruits were analyzed by RP-HPLC. Among the flavonols, the content of myricetin was found to be high in Morus alba (88 mg/100 g DW), the amount of quercetin as high in Morus laevigata (145 mg/100 g DW) while kaempferol was highest in the Korona strawberry (98 mg/100 g DW) at fully ripened stage. Of the six phenolic acids detected, p-hydroxybenzoic and p-coumaric acid were the major compounds in the strawberry. M. laevigata and M. nigra contained p-coumaric acid and vanillic acid while M. macroura and M. alba contained p-hydroxy-benzoic acid and chlorogenic acid as the major phenolic acids. Overall, a trend to an increase in the percentage of extraction yield, TPC, TFC, flavonols and phenolic acids was observed as maturity progressed from un-ripened to fully-ripened stages. PMID:22605997

  19. A global experiment suggests climate warming will not accelerate litter decomposition in streams but might reduce carbon sequestration.

    PubMed

    Boyero, Luz; Pearson, Richard G; Gessner, Mark O; Barmuta, Leon A; Ferreira, Verónica; Graça, Manuel A S; Dudgeon, David; Boulton, Andrew J; Callisto, Marcos; Chauvet, Eric; Helson, Julie E; Bruder, Andreas; Albariño, Ricardo J; Yule, Catherine M; Arunachalam, Muthukumarasamy; Davies, Judy N; Figueroa, Ricardo; Flecker, Alexander S; Ramírez, Alonso; Death, Russell G; Iwata, Tomoya; Mathooko, Jude M; Mathuriau, Catherine; Gonçalves, José F; Moretti, Marcelo S; Jinggut, Tajang; Lamothe, Sylvain; M'Erimba, Charles; Ratnarajah, Lavenia; Schindler, Markus H; Castela, José; Buria, Leonardo M; Cornejo, Aydeé; Villanueva, Verónica D; West, Derek C

    2011-03-01

    The decomposition of plant litter is one of the most important ecosystem processes in the biosphere and is particularly sensitive to climate warming. Aquatic ecosystems are well suited to studying warming effects on decomposition because the otherwise confounding influence of moisture is constant. By using a latitudinal temperature gradient in an unprecedented global experiment in streams, we found that climate warming will likely hasten microbial litter decomposition and produce an equivalent decline in detritivore-mediated decomposition rates. As a result, overall decomposition rates should remain unchanged. Nevertheless, the process would be profoundly altered, because the shift in importance from detritivores to microbes in warm climates would likely increase CO(2) production and decrease the generation and sequestration of recalcitrant organic particles. In view of recent estimates showing that inland waters are a significant component of the global carbon cycle, this implies consequences for global biogeochemistry and a possible positive climate feedback. © 2011 Blackwell Publishing Ltd/CNRS.

  20. Letting Schools off the Hook? Exploring the Role of Australian Secondary Schools in the COAG Year 12 Attainment Agenda

    ERIC Educational Resources Information Center

    Keating, Jack; Savage, Glenn C.; Polesel, John

    2013-01-01

    In 2009, the Council of Australian Governments (COAG) set a target to lift Australia's Year 12 or equivalent attainment rate from 83.5 to 90% by 2015. In the context of global financial uncertainty, the target was rationalised as a means for boosting national productivity and developing human capital to help Australia compete in the global…

  1. Adsorption of water from aqueous acetonitrile on silica-based stationary phases in aqueous normal-phase liquid chromatography.

    PubMed

    Soukup, Jan; Jandera, Pavel

    2014-12-29

    Excess adsorption of water from aqueous acetonitrile mobile phases was investigated on 16 stationary phases using the frontal analysis method and coulometric Karl-Fischer titration. The stationary phases include silica gel and silica-bonded phases with different polarities, octadecyl and cholesterol, phenyl, nitrile, pentafluorophenylpropyl, diol and zwitterionic sulfobetaine and phosphorylcholine ligands bonded on silica, hybrid organic-silica and hydrosilated matrices. Both fully porous and core-shell column types were included. Preferential uptake of water by the columns can be described by Langmuir isotherms. Even though a diffuse rather than a compact adsorbed discrete layer of water on the adsorbent surface can be formed because of the unlimited miscibility of water with acetonitrile, for convenience, the preferentially adsorbed water was expressed in terms of a hypothetical monomolecular water layer equivalent in the inner pores. The uptake of water strongly depends on the polarity and type of the column. Less than one monomolecular water layer equivalent was adsorbed on moderate polar silica hydride-based stationary phases, Ascentis Express F5 and Ascentis Express CN column at the saturation capacity, while on more polar stationary phases, several water layer equivalents were up-taken from the mobile phase. The strongest affinity to water was observed on the ZIC cHILIC stationary phases, where more than nine water layer equivalents were adsorbed onto its surface at its saturation capacity. Columns with bonded hydroxyl and diol ligands show stronger water adsorption in comparison to bare silica. Columns based on hydrosilated silica generally show significantly decreased water uptake in comparison to stationary phases bonded on ordinary silica. Significant correlations were found between the water uptake and the separation selectivity for compounds with strong polarity differences. Copyright © 2014 Elsevier B.V. All rights reserved.

  2. Math and Science Teachers: Recruiting and Retaining California's Workforce. Policy Brief

    ERIC Educational Resources Information Center

    EdSource, 2008

    2008-01-01

    Middle and high school math and science teachers provide the foundation for education in the growing science, technology, engineering, and mathematics fields. They are crucial to California's efforts to remain competitive in a global economy. This policy brief looks at the shortage and challenges involved in recruiting and retaining fully prepared…

  3. Student Characteristics, Prior Experiences, and the Perception of Mixed Methods as an Innovation

    ERIC Educational Resources Information Center

    Brown, Sydney E.

    2014-01-01

    There are persistent challenges to teaching mixed methods and innovative solutions are sought in order to address the needs of an increasingly diverse global audience seeking mixed methods instruction. This mixed methods study was conducted to gain insights to course design by more fully understanding the relationships among graduate student…

  4. Designing an Internationationalised Curriculum for Higher Education: Embracing the Local and the Global Citizen

    ERIC Educational Resources Information Center

    Clifford, Valerie; Montgomery, Catherine

    2017-01-01

    In this article, differing interpretations of the internationalisation of higher education curriculum are explored analysing the structural and cultural aspects of the curriculum. Voices of tertiary staff from around the world taking part in a four-week, fully online course, entitled "Internationalising the curriculum for all students"…

  5. 75 FR 1803 - Lower Florida Keys Refuges, Monroe County, FL

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-13

    ... fully assessed and the effect of climate change (e.g., sea level rise) is not known. We would protect... (e.g., hurricanes, wildfire) and global climate change, particularly sea level rise. Current ongoing... evaluate the potential impacts of sea level rise on the ecology of wading birds. Since a primary purpose of...

  6. Exploring the Nature of Disciplinary Teaching and Learning Using Legitimation Code Theory Semantics

    ERIC Educational Resources Information Center

    Clarence, Sherran

    2016-01-01

    Teaching and learning is a growing field of research and practice globally, and increasing investments are being made in developing academics as teachers. An inability to adequately account for disciplinary knowledge can lead to academic development inputs that are unable to fully address the needs of students, educators, or disciplines…

  7. Shifting Patterns of International Higher Education: Ebb and Flow or Sea Change?

    ERIC Educational Resources Information Center

    Middlehurst, Robin

    2013-01-01

    In November 2012, the US Department of Education published its first-ever "fully articulated international strategy." Its two strategic goals are to strengthen US education and advance the international priorities of the US through increasing the global competencies of students, learning from other countries, and engaging in education…

  8. 75 FR 47339 - Bureau of Educational and Cultural Affairs (ECA) Request for Grant Proposals: Global...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-05

    .... Please refer to Solicitation Package for further information. IV.3d.2 Diversity, Freedom and Democracy... including, but not limited to ethnicity, race, gender, religion, geographic location, socio-economic status... countries whose people do not fully enjoy freedom and democracy,'' the Bureau ``shall take appropriate steps...

  9. Subterranean ventilation of allochthonous CO2 governs net CO2 exchange in a semiarid Mediterranean grassland

    USDA-ARS?s Scientific Manuscript database

    Recent research highlights the important role of (semi-) arid ecosystems in the global carbon (C) cycle. However, detailed process based investigations are still necessary in order to fully understand how drylands behave and to determine the main factors currently affecting their C balance with the ...

  10. Theorizing a "Halfie" Researcher's Identity in Transnational Fieldwork

    ERIC Educational Resources Information Center

    Subedi, Binaya

    2006-01-01

    The topic of how reflexivity ought to be utilized in the global aspect of research is yet to be fully theorized in educational research. Through the use of rigorous reflexivity, this paper examines a "halfie" researcher's negotiation of insider and outsider identities within his transnational home/field site of Nepal. By examining how…

  11. Optimization of Influenza Antiviral Response in Texas

    DTIC Science & Technology

    2015-03-01

    populations of the world . Through the past century, four global influenza pandemics and a severe influenza epidemic have shown that the world is not fully...2 2. 1928 U.S. Influenza Epidemic .............................................................4 3. Asian Flu (1957–1958...7 Figure 5. Locations of cases of swine flu by 15, August 2010 (from World

  12. Formation of Foreign Communicative Competence of Adult Immigrants in the USA

    ERIC Educational Resources Information Center

    Sadovets, Olesya

    2014-01-01

    The necessity of forming foreign communicative competence of adult immigrants has been substantiated. The topicality of this issue for Ukraine has been defined. The experience of Global Talent Bridge, an initiative of World Education Services that is dedicated to helping skilled immigrants fully utilize their talents and education in the United…

  13. Bacterial flora on Cascades frogs in the Klamath Mountains of California

    Treesearch

    Karen Pope

    2013-01-01

    Amphibians are experiencing global declines due in part to the infectious disease chytridiomycosis. Some symbiotic bacteria residents on frog skin have been shown to inhibit the growth of Batrachochytrium dendrobatitis (Bd) but few studies have attempted to fully describe the resident bacterial flora of frog skin. We cultured and sequenced 130...

  14. Circuits of Education, Rural Gentrification, and Family Migration from the Global City

    ERIC Educational Resources Information Center

    Smith, Darren P.; Higley, Rebecca

    2012-01-01

    Although there is recurring empirical evidence of gentrifier families with young children, the importance of education-related factors in the migration and residential decision-making of rural gentrifiers have yet to be fully examined. Using the case study of Cranbrook, Kent, processes of education-led rural gentrification are revealed that are…

  15. A clock steering method: using a third-order type 3 DPLL equivalent to a Kalman filter with a delay

    NASA Astrophysics Data System (ADS)

    Wu, Yiwei; Gong, Hang; Zhu, Xiangwei; Ou, Gang

    2015-12-01

    In this paper we propose a new clock steering method, which uses a third-order type 3 digital phase locked loop (DPLL) which is equivalent to a Kalman filter with a delay. A general overview of the theoretical framework is described in detail including the transfer functions, the structure and control values, the specifications, and the approach to choosing a parameter. Simulations show that the performance of the time and frequency steering errors and the frequency stability are quite desirable. Comparing with traditional clock steering methods, it is easier to work with just one parameter. The DPLL method satisfies the requirements of generating a local representation of universal time coordinated and the system time of a global navigation satellite system.

  16. Spectral Profiler Probe for In Situ Snow Grain Size and Composition Stratigraphy

    NASA Technical Reports Server (NTRS)

    Berisford, Daniel F.; Molotch, Noah P.; Painter, Thomas

    2012-01-01

    An ultimate goal of the climate change, snow science, and hydrology communities is to measure snow water equivalent (SWE) from satellite measurements. Seasonal SWE is highly sensitive to climate change and provides fresh water for much of the world population. Snowmelt from mountainous regions represents the dominant water source for 60 million people in the United States and over one billion people globally. Determination of snow grain sizes comprising mountain snowpack is critical for predicting snow meltwater runoff, understanding physical properties and radiation balance, and providing necessary input for interpreting satellite measurements. Both microwave emission and radar backscatter from the snow are dominated by the snow grain size stratigraphy. As a result, retrieval algorithms for measuring snow water equivalents from orbiting satellites is largely hindered by inadequate knowledge of grain size.

  17. Ongoing drought-induced uplift in the western United States.

    USGS Publications Warehouse

    Borsa, Adrian Antal; Agnew, Duncan Carr; Cayan, Daniel R.

    2014-01-01

    The western United States has been experiencing severe drought since 2013. The solid earth response to the accompanying loss of surface and near-surface water mass should be a broad region of uplift. We use seasonally adjusted time series from continuously operating global positioning system stations to measure this uplift, which we invert to estimate mass loss. The median uplift is 5 millimeters (mm), with values up to 15 mm in California’s mountains. The associated pattern of mass loss, ranging up to 50 centimeters (cm) of water equivalent, is consistent with observed decreases in precipitation and streamflow. We estimate the total deficit to be ~240 gigatons, equivalent to a 10-cm layer of water over the entire region, or the annual mass loss from the Greenland Ice Sheet.

  18. Impacts of future radiation management scenarios on terrestrial carbon dynamics simulated with fully coupled NorESM

    NASA Astrophysics Data System (ADS)

    Ekici, Altug; Tjiputra, Jerry; Grini, Alf; Muri, Helene

    2017-04-01

    We have simulated 3 different radiation management geoengineering methods (CCT - cirrus cloud thinning; SAI - stratospheric aerosol injection; MSB - marine sky brightening) on top of future RCP8.5 scenario with the fully coupled Norwegian Earth System Model (NorESM). A globally consistent cooling in both atmosphere and soil is observed with all methods. However, precipitation patterns are dependent on the used method. Globally CCT and MSB methods do not affect the vegetation carbon budget, while SAI leads to a loss compared to RCP8.5 simulations. Spatially the most sensitive region is the tropics. Here, the changes in vegetation carbon content are related to the precipitation changes. Increase in soil carbon is projected in all three methods, the biggest change seen in SAI method. Simulations with CCT method leads to twice as much soil carbon retention in the tropics compared to the MSB method. Our findings show that there are unforeseen regional consequences of such geoengineering methods in the biogeochemical cycles and they should be considered with care in future climate policies.

  19. Generalization of one-dimensional solute transport: A stochastic-convective flow conceptualization

    NASA Astrophysics Data System (ADS)

    Simmons, C. S.

    1986-04-01

    A stochastic-convective representation of one-dimensional solute transport is derived. It is shown to conceptually encompass solutions of the conventional convection-dispersion equation. This stochastic approach, however, does not rely on the assumption that dispersive flux satisfies Fick's diffusion law. Observable values of solute concentration and flux, which together satisfy a conservation equation, are expressed as expectations over a flow velocity ensemble, representing the inherent random processess that govern dispersion. Solute concentration is determined by a Lagrangian pdf for random spatial displacements, while flux is determined by an equivalent Eulerian pdf for random travel times. A condition for such equivalence is derived for steady nonuniform flow, and it is proven that both Lagrangian and Eulerian pdfs are required to account for specified initial and boundary conditions on a global scale. Furthermore, simplified modeling of transport is justified by proving that an ensemble of effectively constant velocities always exists that constitutes an equivalent representation. An example of how a two-dimensional transport problem can be reduced to a single-dimensional stochastic viewpoint is also presented to further clarify concepts.

  20. On the equivalence of spherical splines with least-squares collocation and Stokes's formula for regional geoid computation

    NASA Astrophysics Data System (ADS)

    Ophaug, Vegard; Gerlach, Christian

    2017-11-01

    This work is an investigation of three methods for regional geoid computation: Stokes's formula, least-squares collocation (LSC), and spherical radial base functions (RBFs) using the spline kernel (SK). It is a first attempt to compare the three methods theoretically and numerically in a unified framework. While Stokes integration and LSC may be regarded as classic methods for regional geoid computation, RBFs may still be regarded as a modern approach. All methods are theoretically equal when applied globally, and we therefore expect them to give comparable results in regional applications. However, it has been shown by de Min (Bull Géod 69:223-232, 1995. doi: 10.1007/BF00806734) that the equivalence of Stokes's formula and LSC does not hold in regional applications without modifying the cross-covariance function. In order to make all methods comparable in regional applications, the corresponding modification has been introduced also in the SK. Ultimately, we present numerical examples comparing Stokes's formula, LSC, and SKs in a closed-loop environment using synthetic noise-free data, to verify their equivalence. All agree on the millimeter level.

  1. Rapid and coordinated processing of global motion images by local clusters of retinal ganglion cells.

    PubMed

    Matsumoto, Akihiro; Tachibana, Masao

    2017-01-01

    Even when the body is stationary, the whole retinal image is always in motion by fixational eye movements and saccades that move the eye between fixation points. Accumulating evidence indicates that the brain is equipped with specific mechanisms for compensating for the global motion induced by these eye movements. However, it is not yet fully understood how the retina processes global motion images during eye movements. Here we show that global motion images evoke novel coordinated firing in retinal ganglion cells (GCs). We simultaneously recorded the firing of GCs in the goldfish isolated retina using a multi-electrode array, and classified each GC based on the temporal profile of its receptive field (RF). A moving target that accompanied the global motion (simulating a saccade following a period of fixational eye movements) modulated the RF properties and evoked synchronized and correlated firing among local clusters of the specific GCs. Our findings provide a novel concept for retinal information processing during eye movements.

  2. Recoupling Industrial Dairy Feedlots and Industrial Farmlands Mitigates the Environmental Impacts of Milk Production in China.

    PubMed

    Fan, Xing; Chang, Jie; Ren, Yuan; Wu, Xu; Du, Yuanyuan; Xu, Ronghua; Liu, Dong; Chang, Scott X; Meyerson, Laura A; Peng, Changhui; Ge, Ying

    2018-04-03

    Dairy production is becoming more industrialized globally, especially in developing countries. The large amount of animal wastes from industrial feedlots cannot be fully used on nearby farmlands, leading to severe environmental problems. Using China as a case study, we found that most dairy feedlots employ a semicoupled mode that only recycles solid manure to farmlands, and only a few dairy feedlots employ a fully coupled mode that recycles both solid and liquid animal manure. To produce 1 ton of milk, the fully coupled mode could reduce greenhouse gas (including carbon dioxide, methane, and nitrous oxide in this paper) emissions by 24%, ammonia emissions by 14%, and N discharge into water by 29%, compared with the semicoupled systems. Coupling feedlots with constructed wetlands can further result in greater mitigation of N leaching into groundwater. However, the fully coupled system has not been widely used due to the low benefit to farmers and the institutional barrier that the feedlot owners have no right to use adjacent farmlands. Since a fully coupled system improves net ecosystem services that favor the public, a policy that supports removing the economic and institutional barriers is necessary. Our approach provides a template for mitigating environmental impacts from livestock production without sacrificing milk production.

  3. CD44 Is a Negative Cell Surface Marker for Pluripotent Stem Cell Identification during Human Fibroblast Reprogramming

    PubMed Central

    Vaz, Candida; Tanavde, Vivek; Lakshmipathy, Uma

    2014-01-01

    Induced pluripotent stem cells (iPSCs) are promising tools for disease research and cell therapy. One of the critical steps in establishing iPSC lines is the early identification of fully reprogrammed colonies among unreprogrammed fibroblasts and partially reprogrammed intermediates. Currently, colony morphology and pluripotent stem cell surface markers are used to identify iPSC colonies. Through additional clonal characterization, we show that these tools fail to distinguish partially reprogrammed intermediates from fully reprogrammed iPSCs. Thus, they can lead to the selection of suboptimal clones for expansion. A subsequent global transcriptome analysis revealed that the cell adhesion protein CD44 is a marker that differentiates between partially and fully reprogrammed cells. Immunohistochemistry and flow cytometry confirmed that CD44 is highly expressed in the human parental fibroblasts used for the reprogramming experiments. It is gradually lost throughout the reprogramming process and is absent in fully established iPSCs. When used in conjunction with pluripotent cell markers, CD44 staining results in the clear identification of fully reprogrammed cells. This combination of positive and negative surface markers allows for easier and more accurate iPSC detection and selection, thus reducing the effort spent on suboptimal iPSC clones. PMID:24416407

  4. Global Electricity Trade Network: Structures and Implications

    PubMed Central

    Ji, Ling; Jia, Xiaoping; Chiu, Anthony S. F.; Xu, Ming

    2016-01-01

    Nations increasingly trade electricity, and understanding the structure of the global power grid can help identify nations that are critical for its reliability. This study examines the global grid as a network with nations as nodes and international electricity trade as links. We analyze the structure of the global electricity trade network and find that the network consists of four sub-networks, and provide a detailed analysis of the largest network, Eurasia. Russia, China, Ukraine, and Azerbaijan have high betweenness measures in the Eurasian sub-network, indicating the degrees of centrality of the positions they hold. The analysis reveals that the Eurasian sub-network consists of seven communities based on the network structure. We find that the communities do not fully align with geographical proximity, and that the present international electricity trade in the Eurasian sub-network causes an approximately 11 million additional tons of CO2 emissions. PMID:27504825

  5. Global Electricity Trade Network: Structures and Implications.

    PubMed

    Ji, Ling; Jia, Xiaoping; Chiu, Anthony S F; Xu, Ming

    2016-01-01

    Nations increasingly trade electricity, and understanding the structure of the global power grid can help identify nations that are critical for its reliability. This study examines the global grid as a network with nations as nodes and international electricity trade as links. We analyze the structure of the global electricity trade network and find that the network consists of four sub-networks, and provide a detailed analysis of the largest network, Eurasia. Russia, China, Ukraine, and Azerbaijan have high betweenness measures in the Eurasian sub-network, indicating the degrees of centrality of the positions they hold. The analysis reveals that the Eurasian sub-network consists of seven communities based on the network structure. We find that the communities do not fully align with geographical proximity, and that the present international electricity trade in the Eurasian sub-network causes an approximately 11 million additional tons of CO2 emissions.

  6. Stochastic process of pragmatic information for 2D spiral wave turbulence in globally and locally coupled Alief-Panfilov oscillators

    NASA Astrophysics Data System (ADS)

    Kuwahara, Jun; Miyata, Hajime; Konno, Hidetoshi

    2017-09-01

    Recently, complex dynamics of globally coupled oscillators have been attracting many researcher's attentions. In spite of their numerous studies, their features of nonlinear oscillator systems with global and local couplings in two-dimension (2D) are not understood fully. The paper focuses on 2D states of coherent, clustered and chaotic oscillation especially under the effect of negative global coupling (NGC) in 2D Alief-Panfilov model. It is found that the tuning NGC can cause various new coupling-parameter dependency on the features of oscillations. Then quantitative characterization of various states of oscillations (so called spiral wave turbulence) is examined by using the pragmatic information (PI) which have been utilized in analyzing multimode laser, solar activity and neuronal systems. It is demonstrated that the dynamics of the PI for various oscillations can be characterized successfully by the Hyper-Gamma stochastic process.

  7. Worldwide orthopaedic research activity 2010-2014: Publication rates in the top 15 orthopaedic journals related to population size and gross domestic product

    PubMed Central

    Hohmann, Erik; Glatt, Vaida; Tetsworth, Kevin

    2017-01-01

    AIM To perform a bibliometric analysis of publications rates in orthopedics in the top 15 orthopaedic journals. METHODS Based on their 2015 impact factor, the fifteen highest ranked orthopaedic journals between January 2010 and December 2014 were used to establish the total number of publications; cumulative impact factor points (IF) per country were determined, and normalized to population size, GDP, and GDP/capita, comparison to the median country output and the global leader. RESULTS Twenty-three thousand and twenty-one orthopaedic articles were published, with 66 countries publishing. The United States had 8149 publications, followed by the United Kingdom (1644) and Japan (1467). The highest IF was achieved by the United States (24744), United Kingdom (4776), and Japan (4053). Normalized by population size Switzerland lead. Normalized by GDP, Croatia was the top achiever. Adjusting GDP/capita, for publications and IF, China, India, and the United States were the leaders. Adjusting for population size and GDP, 28 countries achieved numbers of publications to be considered at least equivalent with the median academic output. Adjusting GDP/capita only China and India reached the number of publications to be considered equivalent to the current global leader, the United States. CONCLUSION Five countries were responsible for 60% of the orthopaedic research output over this 5-year period. After correcting for GDP/capita, only 28 of 66 countries achieved a publication rate equivalent to the median country. The United States, United Kingdom, South Korea, Japan, and Germany were the top five countries for both publication totals and cumulative impact factor points. PMID:28660144

  8. Application of a global magnetospheric-ionospheric current model for dayside and terminator Pi2 pulsations

    NASA Astrophysics Data System (ADS)

    Imajo, S.; Yoshikawa, A.; Uozumi, T.; Ohtani, S.; Nakamizo, A.; Chi, P. J.

    2017-12-01

    Pi2 magnetic oscillations on the dayside are considered to be produced by the ionospheric current that is driven by Pi2-associated electric fields from the high-latitude region, but this idea has not been quantitatively tested. The present study numerically tested the magnetospheric-ionospheric current system for Pi2 consisting of field-aligned currents (FACs) localized in the nightside auroral region, the perpendicular magnetospheric current flowing in the azimuthal direction, and horizontal ionospheric currents driven by the FACs. We calculated the spatial distribution of the ground magnetic field produced by these currents using the Biot-Savart law in a stationary state. The calculated magnetic field reproduced the observational features reported by previous studies; (1) the sense of the H component does not change a wide range of local time sectors at low latitudes; (2) the amplitude of the H component on the dayside is enhanced at the equator; (3) The D component reverses its phase near the dawn and dusk terminators; (4) the meridian of the D-component phase reversal near the dusk terminator is shifted more sunward than that near the dawn terminator; (5) the amplitude of the D component in the morning is larger than that in the early evening. We also derived the global distributions of observed equivalent currents for two Pi2 events. The spatial patterns of dayside equivalent currents were similar to the spatial pattern of numerically derived equivalent currents. The results indicate that the oscillation of the magnetospheric-ionospheric current system is a plausible explanation of Pi2s on the dayside and near the terminator. These results are included in an accepted paper by Imajo et al. [2017JGR, DOI: 10.1002/2017JA024246].

  9. Complex Dynamical Networks Constructed with Fully Controllable Nonlinear Nanomechanical Oscillators.

    PubMed

    Fon, Warren; Matheny, Matthew H; Li, Jarvis; Krayzman, Lev; Cross, Michael C; D'Souza, Raissa M; Crutchfield, James P; Roukes, Michael L

    2017-10-11

    Control of the global parameters of complex networks has been explored experimentally in a variety of contexts. Yet, the more difficult prospect of realizing arbitrary network architectures, especially analog physical networks that provide dynamical control of individual nodes and edges, has remained elusive. Given the vast hierarchy of time scales involved, it also proves challenging to measure a complex network's full internal dynamics. These span from the fastest nodal dynamics to very slow epochs over which emergent global phenomena, including network synchronization and the manifestation of exotic steady states, eventually emerge. Here, we demonstrate an experimental system that satisfies these requirements. It is based upon modular, fully controllable, nonlinear radio frequency nanomechanical oscillators, designed to form the nodes of complex dynamical networks with edges of arbitrary topology. The dynamics of these oscillators and their surrounding network are analog and continuous-valued and can be fully interrogated in real time. They comprise a piezoelectric nanomechanical membrane resonator, which serves as the frequency-determining element within an electrical feedback circuit. This embodiment permits network interconnections entirely within the electrical domain and provides unprecedented node and edge control over a vast region of parameter space. Continuous measurement of the instantaneous amplitudes and phases of every constituent oscillator node are enabled, yielding full and detailed network data without reliance upon statistical quantities. We demonstrate the operation of this platform through the real-time capture of the dynamics of a three-node ring network as it evolves from the uncoupled state to full synchronization.

  10. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Komura, Jun-ichiro, E-mail: junkom@med.tohoku.ac.jp; Ikehata, Hironobu; Mori, Toshio

    During mitosis, chromatin is highly condensed, and activities such as transcription and semiconservative replication do not occur. Consequently, the condensed condition of mitotic chromatin is assumed to inhibit DNA metabolism by impeding the access of DNA-transacting proteins. However, about 40 years ago, several researchers observed unscheduled DNA synthesis in UV-irradiated mitotic chromosomes, suggesting the presence of excision repair. We re-examined this subject by directly measuring the removal of UV-induced DNA lesions by an ELISA and by a Southern-based technique in HeLa cells arrested at mitosis. We observed that the removal of (6-4) photoproducts from the overall genome in mitotic cellsmore » was as efficient as in interphase cells. This suggests that global genome repair of (6-4) photoproducts is fully functional during mitosis, and that the DNA in mitotic chromatin is accessible to proteins involved in this mode of DNA repair. Nevertheless, not all modes of DNA repair seem fully functional during mitosis. We also observed that the removal of cyclobutane pyrimidine dimers from the dihydrofolate reductase and c-MYC genes in mitotic cells was very slow. This suggests that transcription-coupled repair of cyclobutane pyrimidine dimers is compromised or non-functional during mitosis, which is probably the consequence of mitotic transcriptional repression. -- Highlights: Black-Right-Pointing-Pointer Global genome repair of (6-4) photoproducts is fully active in mitotic cells. Black-Right-Pointing-Pointer DNA in condensed mitotic chromatin does not seem inaccessible or inert. Black-Right-Pointing-Pointer Mitotic transcriptional repression may impair transcription-coupled repair.« less

  11. Vision for a worldwide fluvial-sediment information network

    USGS Publications Warehouse

    Gray, J.R.; Osterkamp, W.R.

    2007-01-01

    The WoFSIN is described in the ensuing sections in stand-alone fashion, followed by a section that describes the complementary aspects of the WoFSIN and the International Sediment Initiative. Thus, our first objective is to describe the fundamental components of a WoFSIN. Our second objective is to identify overlap or gaps between the WoFSIN and ISI concepts that might be useful in refining the ISI’s ability to meet its global mission to develop decision support for sediment management at the global scale more fully, cost-effectively, and (or) with enhanced quality.

  12. Global Precipitation Measurement mission data released on This Week @NASA - September 5, 2014

    NASA Image and Video Library

    2014-09-05

    Precipitation information from the first six months of the Global Precipitation Measurement Core Observatory mission now is fully available to the public. Launched from Japan in February, the joint NASA and Japan Aerospace Exploration Agency mission works with international partner satellites to produce precise and standardized data sets on worldwide rainfall, snowfall and other precipitation. The data can be used to improve forecasts of extreme weather events like floods and help decision makers worldwide better manage water resources. Also, Earthquake data from the air, Next ISS crew trains, Talking STEM with students and OSIRIS-REx time capsule!

  13. A Self-Tuning Kalman Filter for Autonomous Navigation Using the Global Positioning System (GPS)

    NASA Technical Reports Server (NTRS)

    Truong, Son H.

    1999-01-01

    Most navigation systems currently operated by NASA are ground-based, and require extensive support to produce accurate results. Recently developed systems that use Kalman filter and GPS (Global Positioning Systems) data for orbit determination greatly reduce dependency on ground support, and have potential to provide significant economies for NASA spacecraft navigation. These systems, however, still rely on manual tuning from analysts. A sophisticated neuro-fuzzy component fully integrated with the flight navigation system can perform the self-tuning capability for the Kalman filter and help the navigation system recover from estimation errors in real time.

  14. Ethanol for a sustainable energy future.

    PubMed

    Goldemberg, José

    2007-02-09

    Renewable energy is one of the most efficient ways to achieve sustainable development. Increasing its share in the world matrix will help prolong the existence of fossil fuel reserves, address the threats posed by climate change, and enable better security of the energy supply on a global scale. Most of the "new renewable energy sources" are still undergoing large-scale commercial development, but some technologies are already well established. These include Brazilian sugarcane ethanol, which, after 30 years of production, is a global energy commodity that is fully competitive with motor gasoline and appropriate for replication in many countries.

  15. Global signal modulation of single-trial fMRI response variability: Effect on positive vs negative BOLD response relationship.

    PubMed

    Mayhew, S D; Mullinger, K J; Ostwald, D; Porcaro, C; Bowtell, R; Bagshaw, A P; Francis, S T

    2016-06-01

    In functional magnetic resonance imaging (fMRI), the relationship between positive BOLD responses (PBRs) and negative BOLD responses (NBRs) to stimulation is potentially informative about the balance of excitatory and inhibitory brain responses in sensory cortex. In this study, we performed three separate experiments delivering visual, motor or somatosensory stimulation unilaterally, to one side of the sensory field, to induce PBR and NBR in opposite brain hemispheres. We then assessed the relationship between the evoked amplitudes of contralateral PBR and ipsilateral NBR at the level of both single-trial and average responses. We measure single-trial PBR and NBR peak amplitudes from individual time-courses, and show that they were positively correlated in all experiments. In contrast, in the average response across trials the absolute magnitudes of both PBR and NBR increased with increasing stimulus intensity, resulting in a negative correlation between mean response amplitudes. Subsequent analysis showed that the amplitude of single-trial PBR was positively correlated with the BOLD response across all grey-matter voxels and was not specifically related to the ipsilateral sensory cortical response. We demonstrate that the global component of this single-trial response modulation could be fully explained by voxel-wise vascular reactivity, the BOLD signal standard deviation measured in a separate resting-state scan (resting state fluctuation amplitude, RSFA). However, bilateral positive correlation between PBR and NBR regions remained. We further report that modulations in the global brain fMRI signal cannot fully account for this positive PBR-NBR coupling and conclude that the local sensory network response reflects a combination of superimposed vascular and neuronal signals. More detailed quantification of physiological and noise contributions to the BOLD signal is required to fully understand the trial-by-trial PBR and NBR relationship compared with that of average responses. Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.

  16. Mathematical investigation of one-way transform matrix options.

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Cooper, James Arlin

    2006-01-01

    One-way transforms have been used in weapon systems processors since the mid- to late-1970s in order to help recognize insertion of correct pre-arm information while maintaining abnormal-environment safety. Level-One, Level-Two, and Level-Three transforms have been designed. The Level-One and Level-Two transforms have been implemented in weapon systems, and both of these transforms are equivalent to matrix multiplication applied to the inserted information. The Level-Two transform, utilizing a 6 x 6 matrix, provided the basis for the ''System 2'' interface definition for Unique-Signal digital communication between aircraft and attached weapons. The investigation described in this report was carried out to findmore » out if there were other size matrices that would be equivalent to the 6 x 6 Level-Two matrix. One reason for the investigation was to find out whether or not other dimensions were possible, and if so, to derive implementation options. Another important reason was to more fully explore the potential for inadvertent inversion. The results were that additional implementation methods were discovered, but no inversion weaknesses were revealed.« less

  17. Generation of 3D Skin Equivalents Fully Reconstituted from Human Induced Pluripotent Stem Cells (iPSCs)

    PubMed Central

    Guo, Zongyou; Liu, Liang; Higgins, Claire A.; Christiano, Angela M.

    2013-01-01

    Recent generation of patient-specific induced pluripotent stem cells (PS-iPSCs) provides significant advantages for cell- and gene-based therapy. Establishment of iPSC-based therapy for skin diseases requires efficient methodology for differentiating iPSCs into both keratinocytes and fibroblasts, the major cellular components of the skin, as well as the reconstruction of skin structures using these iPSC-derived skin components. We previously reported generation of keratinocytes from human iPSCs for use in the treatment of recessive dystrophic epidermolysis bullosa (RDEB) caused by mutations in the COL7A1 gene. Here, we developed a protocol for differentiating iPSCs into dermal fibroblasts, which also produce type VII collagen and therefore also have the potential to treat RDEB. Moreover, we generated in vitro 3D skin equivalents composed exclusively human iPSC-derived keratinocytes and fibroblasts for disease models and regenerative therapies for skin diseases, first demonstrating that iPSCs can provide the basis for modeling a human organ derived entirely from two different types of iPSC-derived cells. PMID:24147053

  18. The effect of stratification on premixed swirl-flame flashback by using porous center-body injection

    NASA Astrophysics Data System (ADS)

    McCaslin, Andrew; Ranjan, Rakesh; Clemens, Noel

    2016-11-01

    Boundary layer flashback must be prevented in order to stably operate stationary gas turbines. One strategy to avoid flashback is to create equivalence-ratio stratification, such as by reducing the fuel/air ratio in the boundary layer below the flammability limit. Typically, stratification is achieved by using radially non-uniform fuel injection. The goal of the current study is to reduce the propensity of flashback in a premixed annular swirl combustor that uses a premix section with center-body. A porous metal center-body (10 micron pore size) is used to bleed air directly into the boundary layer and thus locally reduce the equivalence ratio. Planar laser-induced fluorescence imaging of anisole-seeded flow is carried out to assess the stratification in the flow. Time-resolved PIV and chemiluminescence imaging are used to investigate flashback at atmospheric pressure conditions. A comparative study between fully premixed and stratified flame flashback is conducted to determine how stratification influences flashback physics. This work was sponsored by the DOE NETL under Grant DEFC2611-FE0007107. This source of funding is gratefully acknowledged.

  19. Chain stiffness, salt valency, and concentration influences on titration curves of polyelectrolytes: Monte Carlo simulations

    NASA Astrophysics Data System (ADS)

    Carnal, Fabrice; Stoll, Serge

    2011-01-01

    Monte Carlo simulations have been used to study two different models of a weak linear polyelectrolyte surrounded by explicit counterions and salt particles: (i) a rigid rod and (ii) a flexible chain. We focused on the influence of the pH, chain stiffness, salt concentration, and valency on the polyelectrolyte titration process and conformational properties. It is shown that chain acid-base properties and conformational properties are strongly modified when multivalent salt concentration variation ranges below the charge equivalence. Increasing chain stiffness allows to minimize intramolecular electrostatic monomer interactions hence improving the deprotonation process. The presence of di and trivalent salt cations clearly promotes the chain degree of ionization but has only a limited effect at very low salt concentration ranges. Moreover, folded structures of fully charged chains are only observed when multivalent salt at a concentration equal or above charge equivalence is considered. Long-range electrostatic potential is found to influence the distribution of charges along and around the polyelectrolyte backbones hence resulting in a higher degree of ionization and a lower attraction of counterions and salt particles at the chain extremities.

  20. Chain stiffness, salt valency, and concentration influences on titration curves of polyelectrolytes: Monte Carlo simulations.

    PubMed

    Carnal, Fabrice; Stoll, Serge

    2011-01-28

    Monte Carlo simulations have been used to study two different models of a weak linear polyelectrolyte surrounded by explicit counterions and salt particles: (i) a rigid rod and (ii) a flexible chain. We focused on the influence of the pH, chain stiffness, salt concentration, and valency on the polyelectrolyte titration process and conformational properties. It is shown that chain acid-base properties and conformational properties are strongly modified when multivalent salt concentration variation ranges below the charge equivalence. Increasing chain stiffness allows to minimize intramolecular electrostatic monomer interactions hence improving the deprotonation process. The presence of di and trivalent salt cations clearly promotes the chain degree of ionization but has only a limited effect at very low salt concentration ranges. Moreover, folded structures of fully charged chains are only observed when multivalent salt at a concentration equal or above charge equivalence is considered. Long-range electrostatic potential is found to influence the distribution of charges along and around the polyelectrolyte backbones hence resulting in a higher degree of ionization and a lower attraction of counterions and salt particles at the chain extremities.

  1. Global Sensitivity of Simulated Water Balance Indicators Under Future Climate Change in the Colorado Basin

    NASA Astrophysics Data System (ADS)

    Bennett, Katrina E.; Urrego Blanco, Jorge R.; Jonko, Alexandra; Bohn, Theodore J.; Atchley, Adam L.; Urban, Nathan M.; Middleton, Richard S.

    2018-01-01

    The Colorado River Basin is a fundamentally important river for society, ecology, and energy in the United States. Streamflow estimates are often provided using modeling tools which rely on uncertain parameters; sensitivity analysis can help determine which parameters impact model results. Despite the fact that simulated flows respond to changing climate and vegetation in the basin, parameter sensitivity of the simulations under climate change has rarely been considered. In this study, we conduct a global sensitivity analysis to relate changes in runoff, evapotranspiration, snow water equivalent, and soil moisture to model parameters in the Variable Infiltration Capacity (VIC) hydrologic model. We combine global sensitivity analysis with a space-filling Latin Hypercube Sampling of the model parameter space and statistical emulation of the VIC model to examine sensitivities to uncertainties in 46 model parameters following a variance-based approach. We find that snow-dominated regions are much more sensitive to uncertainties in VIC parameters. Although baseflow and runoff changes respond to parameters used in previous sensitivity studies, we discover new key parameter sensitivities. For instance, changes in runoff and evapotranspiration are sensitive to albedo, while changes in snow water equivalent are sensitive to canopy fraction and Leaf Area Index (LAI) in the VIC model. It is critical for improved modeling to narrow uncertainty in these parameters through improved observations and field studies. This is important because LAI and albedo are anticipated to change under future climate and narrowing uncertainty is paramount to advance our application of models such as VIC for water resource management.

  2. Sensitivity analysis of a wing aeroelastic response

    NASA Technical Reports Server (NTRS)

    Kapania, Rakesh K.; Eldred, Lloyd B.; Barthelemy, Jean-Francois M.

    1991-01-01

    A variation of Sobieski's Global Sensitivity Equations (GSE) approach is implemented to obtain the sensitivity of the static aeroelastic response of a three-dimensional wing model. The formulation is quite general and accepts any aerodynamics and structural analysis capability. An interface code is written to convert one analysis's output to the other's input, and visa versa. Local sensitivity derivatives are calculated by either analytic methods or finite difference techniques. A program to combine the local sensitivities, such as the sensitivity of the stiffness matrix or the aerodynamic kernel matrix, into global sensitivity derivatives is developed. The aerodynamic analysis package FAST, using a lifting surface theory, and a structural package, ELAPS, implementing Giles' equivalent plate model are used.

  3. Assessment of dynamic effects on aircraft design loads: The landing impact case

    NASA Astrophysics Data System (ADS)

    Bronstein, Michael; Feldman, Esther; Vescovini, Riccardo; Bisagni, Chiara

    2015-10-01

    This paper addresses the potential benefits due to a fully dynamic approach to determine the design loads of a mid-size business jet. The study is conducted by considering the fuselage midsection of the DAEDALOS aircraft model with landing impact conditions. The comparison is presented in terms of stress levels between the novel dynamic approach and the standard design practice based on the use of equivalent static loads. The results illustrate that a slight reduction of the load levels can be achieved, but careful modeling of the damping level is needed. Guidelines for an improved load definition are discussed, and suggestions for future research activities are provided.

  4. Digital Fresnel reflection holography for high-resolution 3D near-wall flow measurement.

    PubMed

    Kumar, S Santosh; Hong, Jiarong

    2018-05-14

    We propose a novel backscatter holographic imaging system, as a compact and effective tool for 3D near-wall flow diagnostics at high resolutions, utilizing light reflected at the solid-liquid interface as a reference beam. The technique is fully calibrated, and is demonstrated in a densely seeded channel to achieve a spatial resolution of near-wall flows equivalent to or exceeding prior digital inline holographic measurements using local tracer seeding technique. Additionally, we examined the effects of seeding concentration and laser coherence on the measurement resolution and sample volume resolved, demonstrating the potential to manipulate sample domain by tuning the laser coherence profile.

  5. Thrust measurements of a complete axisymmetric scramjet in an impulse facility

    NASA Technical Reports Server (NTRS)

    Paull, A.; Stalker, R. J.; Mee, D.

    1995-01-01

    This paper describes tests which were conducted in the hypersonic impulse facility T4 on a fully integrated axisymmetric scramjet configuration. In these tests the net force on the scramjet vehicle was measured using a deconvolution force balance. This measurement technique and its application to a complex model such as the scramjet are discussed. Results are presented for the scramjet's aerodynamic drag and the net force on the scramjet when fuel is injected into the combustion chambers. It is shown that a scramjet using a hydrogen-silane fuel produces greater thrust than its aerodynamic drag at flight speeds equivalent to 260 m/s.

  6. Analyzing The Impacts of the Biogas-to-Electricity Purchase Incentives on Electric Vehicle Deployment with the MA3T Vehicle Choice Model

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Podkaminer, Kara; Xie, Fei; Lin, Zhenhong

    This analysis represents the biogas-to-electricity pathway under the Renewable Fuel Standard (RFS) as a point of purchase incentive and tests the impact of this incentive on EV deployment using a vehicle consumer choice model. The credit value generated under this policy was calculated in a number of scenarios based on electricity use of each power train choice on a yearly basis over the 15 year vehicle lifetime, accounting for the average electric vehicle miles travelled and vehicle efficiency, competition for biogas-derived electricity among electric vehicles (EVs), the RIN equivalence value and the time value of money. The credit value calculationmore » in each of these scenarios is offered upfront as a point of purchase incentive for EVs using the Market Acceptance of Advanced Automotive Technologies (MA3T) vehicle choice model, which tracks sales, fleet size and energy use over time. The majority of the scenarios use a proposed RIN equivalence value, which increases the credit value as a way to explore the analysis space. Additional model runs show the relative impact of the equivalence value on EV deployment. The MA3T model output shows that a consumer incentive accelerates the deployment of EVs for all scenarios relative to the baseline (no policy) case. In the scenario modeled to represent the current biogas-to-electricity generation capacity (15 TWh/year) with a 5.24kWh/RIN equivalence value, the policy leads to an additional 1.4 million plug-in hybrid electric vehicles (PHEVs) and 3.5 million battery electric vehicles (BEVs) in 2025 beyond the no-policy case of 1.3 million PHEVs and 2.1 million BEVs when the full value of the credit is passed on to the consumer. In 2030, this increases to 2.4 million PHEVs and 7.3 million BEVs beyond the baseline. This larger impact on BEVs relative to PHEVs is due in part to the larger credit that BEVs receive in the model based on the greater percentage of electric vehicle miles traveled by BEVs relative to PHEVs. In this scenario 2025 also represents the last year in which biogas-derived electricity is able to fully supply the transportation electricity demand in the model. After 2025, the credit value declines on a per vehicle basis. At the same time a larger fraction of the credit may shift towards biogas producers in order to incent additional biogas production. The expanded 41 TWh/year biogas availability scenarios represent an increase beyond today s generation capacity and allow greater eRIN generation. With a 5.24kWh/RIN equivalence value, when all of the credit is directed towards reducing vehicle purchase prices, the 41 TWh/year biogas scenario results in 4.1 million additional PHEVs and 12.2 million additional BEVs on the road in 2030 beyond the baseline of 2.5 million PHEVs and 6.1 million BEVs. Under this expanded biogas capacity, biogas-derived electricity generation is able to fully supply electricity for a fleet of over 21 million EVs (15.6 million BEVs and 5.8 million PHEVs) on a yearly basis. In addition to assessing the full value credit scenarios described above, multiple scenarios were analyzed to determine the impact if only a fraction of the credit value was passed on to the consumer. In all of these cases, the EV deployment was scaled back as the fraction of the credit that was passed on to the consumer was reduced. These scenarios can be used to estimate the impact if the credit value is reduced in other ways as well, as demonstrated by the scenarios where the current (22.6 kWh/RIN) equivalence value was used. The EV deployment that results from an equivalence value of 22.6 kWh/RIN equivalence value is roughly equivalent to the EV deployment observed in the 25% case using the 5.24 kWh/RIN equivalence value. A higher equivalence value means that a smaller number of credits, and therefore value, is created for each kWh, and therefore the impact on EV deployment is reduced. This analysis shows several of the drivers that will impact eRIN generation and credit value, and tests the impact of an eRIN point of purchase incentive on EV deployment. This additional incentive can accelerate the deployment of EVs when it is used to reduce vehicle purchase prices. However, the ultimate impact of this policy, as modeled here, will be determined by future RIN prices, the extent to which eRIN credit value can be passed on to the consumer as a point of purchase incentive and the equivalence value.« less

  7. Global Sensitivity of Simulated Water Balance Indicators Under Future Climate Change in the Colorado Basin

    DOE PAGES

    Bennett, Katrina Eleanor; Urrego Blanco, Jorge Rolando; Jonko, Alexandra; ...

    2017-11-20

    The Colorado River basin is a fundamentally important river for society, ecology and energy in the United States. Streamflow estimates are often provided using modeling tools which rely on uncertain parameters; sensitivity analysis can help determine which parameters impact model results. Despite the fact that simulated flows respond to changing climate and vegetation in the basin, parameter sensitivity of the simulations under climate change has rarely been considered. In this study, we conduct a global sensitivity analysis to relate changes in runoff, evapotranspiration, snow water equivalent and soil moisture to model parameters in the Variable Infiltration Capacity (VIC) hydrologic model.more » Here, we combine global sensitivity analysis with a space-filling Latin Hypercube sampling of the model parameter space and statistical emulation of the VIC model to examine sensitivities to uncertainties in 46 model parameters following a variance-based approach.« less

  8. Low-CO(2) electricity and hydrogen: a help or hindrance for electric and hydrogen vehicles?

    PubMed

    Wallington, T J; Grahn, M; Anderson, J E; Mueller, S A; Williander, M I; Lindgren, K

    2010-04-01

    The title question was addressed using an energy model that accounts for projected global energy use in all sectors (transportation, heat, and power) of the global economy. Global CO(2) emissions were constrained to achieve stabilization at 400-550 ppm by 2100 at the lowest total system cost (equivalent to perfect CO(2) cap-and-trade regime). For future scenarios where vehicle technology costs were sufficiently competitive to advantage either hydrogen or electric vehicles, increased availability of low-cost, low-CO(2) electricity/hydrogen delayed (but did not prevent) the use of electric/hydrogen-powered vehicles in the model. This occurs when low-CO(2) electricity/hydrogen provides more cost-effective CO(2) mitigation opportunities in the heat and power energy sectors than in transportation. Connections between the sectors leading to this counterintuitive result need consideration in policy and technology planning.

  9. A global network topology of stock markets: Transmitters and receivers of spillover effects

    NASA Astrophysics Data System (ADS)

    Shahzad, Syed Jawad Hussain; Hernandez, Jose Areola; Rehman, Mobeen Ur; Al-Yahyaee, Khamis Hamed; Zakaria, Muhammad

    2018-02-01

    This paper applies a bivariate cross-quantilogram approach to examine the spillover network structure in the stock markets of 58 countries according to bearish, normal and bullish market scenarios. Our aim is to identify the strongest interdependencies, the directionality of the spillover risk effects, and to detect those equity markets with the potential to cause global systemic risk. The results highlight the role of the US and Canadian equity markets as major spillover transmitters, while the stock markets of Romania, Taiwan and Mexico act mainly as spillover receivers. Particularly strong spillovers are observed from the Canadian and US equity markets towards the Irish market, and from the Brazilian equity market towards the Kenyan equivalent. The equity market networks suggest that only the US equity market can trigger systemic risk on a global scale. Implications of the results are discussed.

  10. Electrical description of N2 capacitively coupled plasmas with the global model

    NASA Astrophysics Data System (ADS)

    Cao, Ming-Lu; Lu, Yi-Jia; Cheng, Jia; Ji, Lin-Hong; Engineering Design Team

    2016-10-01

    N2 discharges in a commercial capacitively coupled plasma reactor are modelled by a combination of an equivalent circuit and the global model, for a range of gas pressure at 1 4 Torr. The ohmic and inductive plasma bulk and the capacitive sheath are represented as LCR elements, with electrical characteristics determined by plasma parameters. The electron density and electron temperature are obtained from the global model in which a Maxwellian electron distribution is assumed. Voltages and currents are recorded by a VI probe installed after the match network. Using the measured voltage as an input, the current flowing through the discharge volume is calculated from the electrical model and shows excellent agreement with the measurements. The experimentally verified electrical model provides a simple and accurate description for the relationship between the external electrical parameters and the plasma properties, which can serve as a guideline for process window planning in industrial applications.

  11. High-resolution Local Gravity Model of the South Pole of the Moon from GRAIL Extended Mission Data

    NASA Technical Reports Server (NTRS)

    Goossens, Sander Johannes; Sabaka, Terence J.; Nicholas, Joseph B.; Lemoine, Frank G.; Rowlands, David D.; Mazarico, Erwan; Neumann, Gregory A.; Smith, David E.; Zuber, Maria T.

    2014-01-01

    We estimated a high-resolution local gravity field model over the south pole of the Moon using data from the Gravity Recovery and Interior Laboratory's extended mission. Our solution consists of adjustments with respect to a global model expressed in spherical harmonics. The adjustments are expressed as gridded gravity anomalies with a resolution of 1/6deg by 1/6deg (equivalent to that of a degree and order 1080 model in spherical harmonics), covering a cap over the south pole with a radius of 40deg. The gravity anomalies have been estimated from a short-arc analysis using only Ka-band range-rate (KBRR) data over the area of interest. We apply a neighbor-smoothing constraint to our solution. Our local model removes striping present in the global model; it reduces the misfit to the KBRR data and improves correlations with topography to higher degrees than current global models.

  12. Global Sensitivity of Simulated Water Balance Indicators Under Future Climate Change in the Colorado Basin

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Bennett, Katrina Eleanor; Urrego Blanco, Jorge Rolando; Jonko, Alexandra

    The Colorado River basin is a fundamentally important river for society, ecology and energy in the United States. Streamflow estimates are often provided using modeling tools which rely on uncertain parameters; sensitivity analysis can help determine which parameters impact model results. Despite the fact that simulated flows respond to changing climate and vegetation in the basin, parameter sensitivity of the simulations under climate change has rarely been considered. In this study, we conduct a global sensitivity analysis to relate changes in runoff, evapotranspiration, snow water equivalent and soil moisture to model parameters in the Variable Infiltration Capacity (VIC) hydrologic model.more » Here, we combine global sensitivity analysis with a space-filling Latin Hypercube sampling of the model parameter space and statistical emulation of the VIC model to examine sensitivities to uncertainties in 46 model parameters following a variance-based approach.« less

  13. Low and High Frequency Models of Response Statistics of a Cylindrical Orthogrid Vehicle Panel to Acoustic Excitation

    NASA Technical Reports Server (NTRS)

    Smith, Andrew; LaVerde, Bruce; Teague, David; Gardner, Bryce; Cotoni, Vincent

    2010-01-01

    This presentation further develops the orthogrid vehicle panel work. Employed Hybrid Module capabilities to assess both low/mid frequency and high frequency models in the VA One simulation environment. The response estimates from three modeling approaches are compared to ground test measurements. Detailed Finite Element Model of the Test Article -Expect to capture both the global panel modes and the local pocket mode response, but at a considerable analysis expense (time & resources). A Composite Layered Construction equivalent global stiffness approximation using SEA -Expect to capture response of the global panel modes only. An SEA approximation using the Periodic Subsystem Formulation. A finite element model of a single periodic cell is used to derive the vibroacoustic properties of the entire periodic structure (modal density, radiation efficiency, etc. Expect to capture response at various locations on the panel (on the skin and on the ribs) with less analysis expense

  14. An intercomparison of GCM and RCM dynamical downscaling for characterizing the hydroclimatology of California and Nevada

    NASA Astrophysics Data System (ADS)

    Xu, Z.; Rhoades, A.; Johansen, H.; Ullrich, P. A.; Collins, W. D.

    2017-12-01

    Dynamical downscaling is widely used to properly characterize regional surface heterogeneities that shape the local hydroclimatology. However, the factors in dynamical downscaling, including the refinement of model horizontal resolution, large-scale forcing datasets and dynamical cores, have not been fully evaluated. Two cutting-edge global-to-regional downscaling methods are used to assess these, specifically the variable-resolution Community Earth System Model (VR-CESM) and the Weather Research & Forecasting (WRF) regional climate model, under different horizontal resolutions (28, 14, and 7 km). Two groups of WRF simulations are driven by either the NCEP reanalysis dataset (WRF_NCEP) or VR-CESM outputs (WRF_VRCESM) to evaluate the effects of the large-scale forcing datasets. The impacts of dynamical core are assessed by comparing the VR-CESM simulations to the coupled WRF_VRCESM simulations with the same physical parameterizations and similar grid domains. The simulated hydroclimatology (i.e., total precipitation, snow cover, snow water equivalent and surface temperature) are compared with the reference datasets. The large-scale forcing datasets are critical to the WRF simulations in more accurately simulating total precipitation, SWE and snow cover, but not surface temperature. Both the WRF and VR-CESM results highlight that no significant benefit is found in the simulated hydroclimatology by just increasing horizontal resolution refinement from 28 to 7 km. Simulated surface temperature is sensitive to the choice of dynamical core. WRF generally simulates higher temperatures than VR-CESM, alleviates the systematic cold bias of DJF temperatures over the California mountain region, but overestimates the JJA temperature in California's Central Valley.

  15. Economic consequences of paratuberculosis control in dairy cattle: A stochastic modeling study.

    PubMed

    Smith, R L; Al-Mamun, M A; Gröhn, Y T

    2017-03-01

    The cost of paratuberculosis to dairy herds, through decreased milk production, early culling, and poor reproductive performance, has been well-studied. The benefit of control programs, however, has been debated. A recent stochastic compartmental model for paratuberculosis transmission in US dairy herds was modified to predict herd net present value (NPV) over 25 years in herds of 100 and 1000 dairy cattle with endemic paratuberculosis at initial prevalence of 10% and 20%. Control programs were designed by combining 5 tests (none, fecal culture, ELISA, PCR, or calf testing), 3 test-related culling strategies (all test-positive, high-positive, or repeated positive), 2 test frequencies (annual and biannual), 3 hygiene levels (standard, moderate, or improved), and 2 cessation decisions (testing ceased after 5 negative whole-herd tests or testing continued). Stochastic dominance was determined for each herd scenario; no control program was fully dominant for maximizing herd NPV in any scenario. Use of the ELISA test was generally preferred in all scenarios, but no paratuberculosis control was highly preferred for the small herd with 10% initial prevalence and was frequently preferred in other herd scenarios. Based on their effect on paratuberculosis alone, hygiene improvements were not found to be as cost-effective as test-and-cull strategies in most circumstances. Global sensitivity analysis found that economic parameters, such as the price of milk, had more influence on NPV than control program-related parameters. We conclude that paratuberculosis control can be cost effective, and multiple control programs can be applied for equivalent economic results. Copyright © 2017 Elsevier B.V. All rights reserved.

  16. Role of compostable tableware in food service and waste management. A life cycle assessment study.

    PubMed

    Fieschi, Maurizio; Pretato, Ugo

    2018-03-01

    It is estimated that in Europe 88-100 million tonnes of food waste are generated every year, with a Global Warming Potential (GWP) of around 227 MT of CO 2 equivalents generated for their collection and disposal. A 12% of this waste is estimated to arise from food service within the hospitality sector, which includes quick service restaurants, casual and fine dining, contract catering (canteens, prisons, hospitals, schools etc.) as well as indoor and outdoor events and exhibitions. Given this considerable amount and that the mixed unsorted collection is often the only practicable way to handle such waste flows, the choice of tableware and cutlery can make a big difference in facilitating waste collection as well as in reducing the overall environmental impact of food waste management. This study compares the environmental performance of using biodegradable & compostable single use tableware with organic recycling of food waste through composting against a traditional scenario using fossil-based plastic tableware and disposal of the waste flows through incineration and landfill. The study has taken into account the main requirements of the recently published Product Environmental Footprint (PEF) methodology of the European Commission. The results confirm that the use of biodegradable and compostable tableware combined with organic recycling is the preferred option for catering in quick service restaurants, contract catering and events, since it reduces significantly the carbon, water and resource footprint and is fully in line with the principles of a circular economy. Copyright © 2017 Elsevier Ltd. All rights reserved.

  17. Assessing the Impact of Topography on Groundwater Salinization Due to Storm Surge Inundation

    NASA Astrophysics Data System (ADS)

    Yu, X.; Yang, J.; Graf, T.; Koneshloo, M.; O'Neal, M. A.; Michael, H. A.

    2015-12-01

    The sea-level rise and increase in the frequency and intensity of coastal storms due to climate change are likely to exacerbate adverse effects of storm surges on low-lying coastal areas. The landward flow of water during storm surges introduces salt to surficial coastal aquifers and threatens groundwater resources. Coastal topography (e.g. ponds, dunes, canals) likely has a strong impact on overwash and salinization processes, but is generally highly simplified in modeling studies. To understand the topographic impacts on groundwater salinization, we modeled overwash and variable-density groundwater flow and salt transport in 3D using the fully coupled surface and subsurface numerical simulator, HydroGeoSphere. The model simulates the coastal aquifer as an integrated system considering processes such as overland flow, coupled surface and subsurface exchange, variably saturated flow, and variable-density flow. To represent various coastal landscape types, we started with realistic coastal topography from Delaware, USA, and then generated synthetic fields with differing shore-perpendicular connectivity and surface depressions. The groundwater salinization analysis suggested that the topographic connectivity promoting overland flow controls the volume of aquifer that is salinized. In contrast, depression storage of surface water mainly controls the time for infiltrated salt to flush from the aquifer. The results indicate that for a range of synthetic conditions, topography increases the flushing time of salt by 20-300% relative to an equivalent "simple slope" in which topographic variation is absent. Our study suggests that topography have a significant impact on overwash salinization, with important implications for land management at local scales and groundwater vulnerability assessment at regional to global scales.

  18. Evaluation of the Retinal Vasculature in Hypertension and Chronic Kidney Disease in an Elderly Population of Irish Nuns.

    PubMed

    McGowan, Amy; Silvestri, Giuliana; Moore, Evelyn; Silvestri, Vittorio; Patterson, Christopher C; Maxwell, Alexander P; McKay, Gareth J

    2015-01-01

    Chronic kidney disease (CKD) and hypertension are global public health problems associated with considerable morbidity, premature mortality and attendant healthcare costs. Previous studies have highlighted that non-invasive examination of the retinal microcirculation can detect microvascular pathology that is associated with systemic disorders of the circulatory system such as hypertension. We examined the associations between retinal vessel caliber (RVC) and fractal dimension (DF), with both hypertension and CKD in elderly Irish nuns. Data from 1233 participants in the cross-sectional observational Irish Nun Eye Study (INES) were assessed from digital photographs with a standardized protocol using computer-assisted software. Multivariate regression analyses were used to assess associations with hypertension and CKD, with adjustment for age, body mass index (BMI), refraction, fellow eye RVC, smoking, alcohol consumption, ischemic heart disease (IHD), cerebrovascular accident (CVA), diabetes and medication use. In total, 1122 (91%) participants (mean age: 76.3 [range: 56-100] years) had gradable retinal images of sufficient quality for blood vessel assessment. Hypertension was significantly associated with a narrower central retinal arteriolar equivalent (CRAE) in a fully adjusted analysis (P = 0.002; effect size = -2.16 μm; 95% confidence intervals [CI]: -3.51, -0.81 μm). No significant associations between other retinal vascular parameters and hypertension or between any retinal vascular parameters and CKD were found. Individuals with hypertension have significantly narrower retinal arterioles which may afford an earlier opportunity for tailored prevention and treatment options to optimize the structure and function of the microvasculature, providing additional clinical utility. No significant associations between retinal vascular parameters and CKD were detected.

  19. Mutual learning and reverse innovation--where next?

    PubMed

    Crisp, Nigel

    2014-03-28

    There is a clear and evident need for mutual learning in global health systems. It is increasingly recognized that innovation needs to be sourced globally and that we need to think in terms of co-development as ideas are developed and spread from richer to poorer countries and vice versa. The Globalization and Health journal's ongoing thematic series, "Reverse innovation in global health systems: learning from low-income countries" illustrates how mutual learning and ideas about so-called "reverse innovation" or "frugal innovation" are being developed and utilized by researchers and practitioners around the world. The knowledge emerging from the series is already catalyzing change and challenging the status quo in global health. The path to truly "global innovation flow", although not fully established, is now well under way. Mobilization of knowledge and resources through continuous communication and awareness raising can help sustain this movement. Global health learning laboratories, where partners can support each other in generating and sharing lessons, have the potential to construct solutions for the world. At the heart of this dialogue is a focus on creating practical local solutions and, simultaneously, drawing out the lessons for the whole world.

  20. Magnetostratigraphy susceptibility for the Guadalupian Series GSSPs (Middle Permian) in Guadalupe Mountains National Park and adjacent areas in West Texas

    USGS Publications Warehouse

    Wardlaw, Bruce R.; Ellwood, Brooks B.; Lambert, Lance L.; Tomkin, Jonathan H.; Bell, Gordon L.; Nestell, Galina P.

    2012-01-01

    Here we establish a magnetostratigraphy susceptibility zonation for the three Middle Permian Global boundary Stratotype Sections and Points (GSSPs) that have recently been defined, located in Guadalupe Mountains National Park, West Texas, USA. These GSSPs, all within the Middle Permian Guadalupian Series, define (1) the base of the Roadian Stage (base of the Guadalupian Series), (2) the base of the Wordian Stage and (3) the base of the Capitanian Stage. Data from two additional stratigraphic successions in the region, equivalent in age to the Kungurian–Roadian and Wordian–Capitanian boundary intervals, are also reported. Based on low-field, mass specific magnetic susceptibility (χ) measurements of 706 closely spaced samples from these stratigraphic sections and time-series analysis of one of these sections, we (1) define the magnetostratigraphy susceptibility zonation for the three Guadalupian Series Global boundary Stratotype Sections and Points; (2) demonstrate that χ datasets provide a proxy for climate cyclicity; (3) give quantitative estimates of the time it took for some of these sediments to accumulate; (4) give the rates at which sediments were accumulated; (5) allow more precise correlation to equivalent sections in the region; (6) identify anomalous stratigraphic horizons; and (7) give estimates for timing and duration of geological events within sections.

  1. Environmental assessment of mild bisulfite pretreatment of forest residues into fermentable sugars for biofuel production.

    PubMed

    Nwaneshiudu, Ikechukwu C; Ganguly, Indroneil; Pierobon, Francesca; Bowers, Tait; Eastin, Ivan

    2016-01-01

    Sugar production via pretreatment and enzymatic hydrolysis of cellulosic feedstock, in this case softwood harvest residues, is a critical step in the biochemical conversion pathway towards drop-in biofuels. Mild bisulfite (MBS) pretreatment is an emerging option for the breakdown and subsequent processing of biomass towards fermentable sugars. An environmental assessment of this process is critical to discern its future sustainability in the ever-changing biofuels landscape. The subsequent cradle-to-gate assessment of a proposed sugar production facility analyzes sugar made from woody biomass using MBS pretreatment across all seven impact categories (functional unit 1 kg dry mass sugar), with a specific focus on potential global warming and eutrophication impacts. The study found that the eutrophication impact (0.000201 kg N equivalent) is less than the impacts from conventional beet and cane sugars, while the global warming impact (0.353 kg CO2 equivalent) falls within the range of conventional processes. This work discusses some of the environmental impacts of designing and operating a sugar production facility that uses MBS as a method of treating cellulosic forest residuals. The impacts of each unit process in the proposed facility are highlighted. A comparison to other sugar-making process is detailed and will inform the growing biofuels literature.

  2. Earth's UV Reflectivity Data from the Ozone Monitoring Instrument on EOS-Aura

    NASA Astrophysics Data System (ADS)

    Larko, D. E.; Mao, J.; Herman, J. R.; Huang, L.; Qin, W.; Labow, G. J.; Lloyd, S. A.; DeLand, M. T.

    2011-12-01

    The Lambert Equivalent Reflectivity (LER), derived from satellite ultraviolet (UV) radiance measurements, represents the equivalent scene reflectivity of the Earth's surface and atmosphere without Rayleigh scattering. It provides a better opportunity to quantify variations of the planetary reflectance and albedo associated with snow/ice, atmospheric aerosols and clouds, since UV reflectance is very low over most land surfaces and water. LER values at 340 nm from the Ozone Monitoring Instrument (OMI) on EOS-Aura have been generated as a new product from the OMI TO3 ozone retrieval algorithm and provided to users in HDF format. The wide field of view of OMI (~2200 km) provides complete global coverage every day with 13 km x 24 km resolution at nadir. These data are then mapped to 1 degree x 1 degree latitude-longitude grid as daily and monthly means for weather and climate studies. The OMI LER data set has been used to validate other UV LER data sets from NOAA and NASA polar orbiting satellites, and has been combined with these data sets to construct a continuous long-term data record of terrestrial UV reflectivity. This paper will present details about the data processing and format of the OMI LER product. Applications of this data set in global climate studies will be demonstrated and discussed in this presentation.

  3. Mapping the zebrafish brain methylome using reduced representation bisulfite sequencing

    PubMed Central

    Chatterjee, Aniruddha; Ozaki, Yuichi; Stockwell, Peter A; Horsfield, Julia A; Morison, Ian M; Nakagawa, Shinichi

    2013-01-01

    Reduced representation bisulfite sequencing (RRBS) has been used to profile DNA methylation patterns in mammalian genomes such as human, mouse and rat. The methylome of the zebrafish, an important animal model, has not yet been characterized at base-pair resolution using RRBS. Therefore, we evaluated the technique of RRBS in this model organism by generating four single-nucleotide resolution DNA methylomes of adult zebrafish brain. We performed several simulations to show the distribution of fragments and enrichment of CpGs in different in silico reduced representation genomes of zebrafish. Four RRBS brain libraries generated 98 million sequenced reads and had higher frequencies of multiple mapping than equivalent human RRBS libraries. The zebrafish methylome indicates there is higher global DNA methylation in the zebrafish genome compared with its equivalent human methylome. This observation was confirmed by RRBS of zebrafish liver. High coverage CpG dinucleotides are enriched in CpG island shores more than in the CpG island core. We found that 45% of the mapped CpGs reside in gene bodies, and 7% in gene promoters. This analysis provides a roadmap for generating reproducible base-pair level methylomes for zebrafish using RRBS and our results provide the first evidence that RRBS is a suitable technique for global methylation analysis in zebrafish. PMID:23975027

  4. A metabolomic study of preterm and term human and formula milk by proton MRS analysis: preliminary results.

    PubMed

    Longini, Mariangela; Tataranno, Maria Luisa; Proietti, Fabrizio; Tortoriello, Mario; Belvisi, Elisa; Vivi, Antonio; Tassini, Maria; Perrone, Serafina; Buonocore, Giuseppe

    2014-10-01

    To investigate changes in global metabolic profile between: 1 - breast milk and formula milk, 2 - breast milk from mothers delivering at different gestational age (GA) collected within one week from delivery, and then week by week until term equivalent age. Proton magnetic resonance spectroscopy (MRS) was used to analyze the water-soluble and lipid fractions extracted from 50 milk samples, 46 human milk at different GA, from 23 weeks of gestation until term equivalent age and four different formula milks. The formula milk for premature infants was the most similar to breast milk of preterm babies. Breast milk showed higher lactose concentrations than formula milk, that conversely presented higher galactose 1-phosphate and maltose concentrations. Mother's milk of very preterm babies (23-25 wks of GA) showed a different metabolic profile from preterm infants ≥29 wks of GA with a subsequent trend to similarity around the 30th week of post-natal age. Breast milk from preterm infants of 29-34 wks, collected up to 40 wks of post-natal age showed a temporal change over the first three weeks of lactation, approaching to zero with the achievement of term age. Metabolome is a promising tool to study human and artificial milk global metabolic profile.

  5. Improving the MODIS Global Snow-Mapping Algorithm

    NASA Technical Reports Server (NTRS)

    Klein, Andrew G.; Hall, Dorothy K.; Riggs, George A.

    1997-01-01

    An algorithm (Snowmap) is under development to produce global snow maps at 500 meter resolution on a daily basis using data from the NASA MODIS instrument. MODIS, the Moderate Resolution Imaging Spectroradiometer, will be launched as part of the first Earth Observing System (EOS) platform in 1998. Snowmap is a fully automated, computationally frugal algorithm that will be ready to implement at launch. Forests represent a major limitation to the global mapping of snow cover as a forest canopy both obscures and shadows the snow underneath. Landsat Thematic Mapper (TM) and MODIS Airborne Simulator (MAS) data are used to investigate the changes in reflectance that occur as a forest stand becomes snow covered and to propose changes to the Snowmap algorithm that will improve snow classification accuracy forested areas.

  6. A robot control architecture supported on contraction theory

    NASA Astrophysics Data System (ADS)

    Silva, Jorge; Sequeira, João; Santos, Cristina

    2017-01-01

    This paper proposes fundamentals for stability and success of a global system composed by a mobile robot, a real environment and a navigation architecture with time constraints. Contraction theory is a typical framework that provides tools and properties to prove the stability and convergence of the global system to a unique fixed point that identifies the mission success. A stability indicator based on the combination contraction property is developed to identify the mission success as a stability measure. The architecture is fully designed through C1 nonlinear dynamical systems and feedthrough maps, which makes it amenable for contraction analysis. Experiments in a realistic and uncontrolled environment are realised to verify if inherent perturbations of the sensory information and of the environment affect the stability and success of the global system.

  7. Training the next generation of global health experts: experiences and recommendations from Pacific Rim universities.

    PubMed

    Withers, Mellissa; Press, David; Wipfli, Heather; McCool, Judith; Chan, Chang-Chuan; Jimba, Masamine; Tremewan, Christopher; Samet, Jonathan

    2016-06-23

    Finding solutions to global health problems will require a highly-trained, inter-disciplinary workforce. Global health education and research can potentially have long-range impact in addressing the global burden of disease and protecting and improving the health of the global population. We conducted an online survey of twelve higher education institutions in the Pacific Rim that spanned the period 2005-2011. Program administrators provided data on program concentrations, student enrollment and student funding opportunities for 41 public health programs, including those specific to global health. The Master of Public Health (MPH) was the most common degree offered. A growing demand for global health education was evident. Enrollment in global health programs increased over three-fold between 2005-2011. Very few institutions had specific global health programs or offered training to undergraduates. Funding for student scholarships was also lacking. The growing demand for global health education suggests that universities in the Pacific Rim should increase educational and training opportunities in this field. Schools of medicine may not be fully equipped to teach global health-related courses and to mentor students who are interested in global health. Increasing the number of dedicated global health research and training institutions in the Pacific Rim can contribute to building capacity in the region. Faculty from different departments and disciplines should be engaged to provide multi-disciplinary global health educational opportunities for undergraduate and graduate students. New, innovative ways to collaborate in education, such as distance education, can also help universities offer a wider range of global health-related courses. Additional funding of global health is also required.

  8. The White Working Class, Racism and Respectability: Victims, Degenerates and Interest-Convergence

    ERIC Educational Resources Information Center

    Gillborn, David

    2010-01-01

    This paper argues that race and class inequalities cannot be fully understood in isolation: their intersectional quality is explored through an analysis of how the White working class were portrayed in popular and political discourse during late 2008 (the timing is highly significant). While global capitalism reeled on the edge of financial…

  9. Bridging the Local with the Global: Building a New University on the Fringes of Europe

    ERIC Educational Resources Information Center

    Pinheiro, Romulo

    2013-01-01

    In Norway, the higher education landscape is undergoing profound transformation. This process is being driven by a number of factors, including demography, competition and academic aspirations, with many so-called "university-colleges" aspiring to become fully-fledged universities. We shed light on the dynamics of one such institution,…

  10. Bananas on Trail: Inspiring Global Connections

    ERIC Educational Resources Information Center

    Jacklein, Charlotte

    2007-01-01

    As an outdoor educator, the author loves the immediacy of her work and the sense of living fully in every moment. She values seeing the change in students as they step out of the complex framework of their home lives and experience themselves and their surroundings from a new perspective. An ongoing challenge for her as an outdoor educator is to…

  11. Strengthening Deeper Learning through Virtual Teams in E-Learning: A Synthesis of Determinants and Best Practices

    ERIC Educational Resources Information Center

    Makani, Joyline; Durier-Copp, Martine; Kiceniuk, Deborah; Blandford, Alieda

    2016-01-01

    Globally, e-learning is gaining popularity as its potential contributions to economic and social development are recognised. However, its full potential has not been realised, as most e-learning practices merely replicate traditional existing teaching methods and have not fully exploited the interactive and social components of peer learning.…

  12. Globalization, National Identity, and Citizenship Education: China's Search for Modernization and a Modern Chinese Citizenry

    ERIC Educational Resources Information Center

    Law, Wing-Wah

    2013-01-01

    Since the early 20th century, numerous scholars have proposed theories and models describing, interpreting, and suggesting the development paths countries have taken or should take. None of these, however, can fully explain China's efforts, mainly through education and citizenship education, to modernize itself and foster a modern citizenry since…

  13. Leadership or Hegemony Investigating U.S. Command of the Sea and Implications for U.S. Grand Strategy

    DTIC Science & Technology

    acknowledged command of the global commons. At the turn of the 21st century, the U.S. was fully dominant in its command of sea and space, and largely... sea ; offers implications for naval doctrine, strategy, and acquisitions; and provides vital lessons to inform U.S. grand strategy.

  14. Informant Accuracy in Recall of Communications and Perception of One’s Place in Global Social Structure and Summary.

    DTIC Science & Technology

    1980-09-01

    group. Perhaps- people in a more fully closed group would be more accurate. 7. The data we collected were essentially precognitive . Perhaps postcognitive...sets yield the fol- lowing results: I. Postcognitive data are (mainly) more accurate than precognitive , but not signif- icantly so. 2. With the

  15. Mergers in Chinese Higher Education: Lessons for Studies in a Global Context

    ERIC Educational Resources Information Center

    Cai, Yuzhuo; Yang, Xi

    2016-01-01

    Since the 1990s, there have been more than 400 cases of university mergers in China, representing various types and involving 1000 public institutions. While China has provided good and abundant cases for studies on university mergers, such an opportunity has not yet been fully exploited by international scholars of university merger research.…

  16. Promoting the Reading Culture Towards Human Capital and Global Development

    ERIC Educational Resources Information Center

    Olasehinde, M. O.; Akanmode, O. A.; Alaiyemola, A. T.; Babatunde, O. T.

    2015-01-01

    It is commonly agreed that a country cannot be fully developed without large-scale investment in her educational scheme since the breakthrough of a country is directly proportional to her educational level. Since the acquisition of effective reading skills has a positive effect on all school subjects, then reading is sine-qua-non for human capital…

  17. On the Margins or at the Center? Distance Education in Higher Education

    ERIC Educational Resources Information Center

    Xiao, Junhong

    2018-01-01

    This reflection focuses on the position of distance education in today's global higher education. Firstly, it identifies three types of convergence of distance and campus-based education--dual mode, add-on/blended, and full convergence--arguing that the last type has yet to be fully realized due to the complexities involved. It then critiques the…

  18. Perfluorocarbons (PFCs), Some of the Immortal Molecules in the Earth's Atmosphere

    ERIC Educational Resources Information Center

    Shallcross, Dudley E.; Martin, Damien

    2011-01-01

    Perfluorocarbons (PFCs) are fully fluorinated hydrocarbons that are used as blood plasma substitutes, in medical imaging and in the cosmetics industry. Most are inert and can also be used as tracers for applications such as air flow. However, because of their C-F bonds and their longevity in the atmosphere, PFCs have large global warming…

  19. From Designing to Organizing New Social Futures: Multiliteracies Pedagogies for Today

    ERIC Educational Resources Information Center

    Penuel, William R.; O'Connor, Kevin

    2018-01-01

    More than 20 years ago, literacy pedagogies informed by the emerging networked world defined by local diversity and global connectedness, new digital media and fast capitalism. Modern people now fully inhabit the world they described, but the contours of that world's racial dynamics and growing inequality call for a refinement of pedagogies that…

  20. Role of H2O2 in the Oxidative Effects of Zinc Exposure in Human Airway Epithelial Cells

    EPA Science Inventory

    Human exposure to particulate matter (PM) is a global environmental health concern. Zinc (Zn(2+)) is a ubiquitous respiratory toxicant that has been associated with PM health effects. However, the molecular mechanism of Zn(2+) toxicity is not fully understood. H202 and Zn(2+) hav...

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