Virtual hydrology observatory: an immersive visualization of hydrology modeling

NASA Astrophysics Data System (ADS)

Su, Simon; Cruz-Neira, Carolina; Habib, Emad; Gerndt, Andreas

2009-02-01

The Virtual Hydrology Observatory will provide students with the ability to observe the integrated hydrology simulation with an instructional interface by using a desktop based or immersive virtual reality setup. It is the goal of the virtual hydrology observatory application to facilitate the introduction of field experience and observational skills into hydrology courses through innovative virtual techniques that mimic activities during actual field visits. The simulation part of the application is developed from the integrated atmospheric forecast model: Weather Research and Forecasting (WRF), and the hydrology model: Gridded Surface/Subsurface Hydrologic Analysis (GSSHA). Both the output from WRF and GSSHA models are then used to generate the final visualization components of the Virtual Hydrology Observatory. The various visualization data processing techniques provided by VTK are 2D Delaunay triangulation and data optimization. Once all the visualization components are generated, they are integrated into the simulation data using VRFlowVis and VR Juggler software toolkit. VR Juggler is used primarily to provide the Virtual Hydrology Observatory application with fully immersive and real time 3D interaction experience; while VRFlowVis provides the integration framework for the hydrologic simulation data, graphical objects and user interaction. A six-sided CAVETM like system is used to run the Virtual Hydrology Observatory to provide the students with a fully immersive experience.

An Integrative, Multi-Scale Computational Model of a Swimming Lamprey Fully Coupled to Its Fluid Environment and Incorporating Proprioceptive Feedback

NASA Astrophysics Data System (ADS)

Hamlet, C. L.; Hoffman, K.; Fauci, L.; Tytell, E.

2016-02-01

The lamprey is a model organism for both neurophysiology and locomotion studies. To study the role of sensory feedback as an organism moves through its environment, a 2D, integrative, multi-scale model of an anguilliform swimmer driven by neural activation from a central pattern generator (CPG) is constructed. The CPG in turn drives muscle kinematics and is fully coupled to the surrounding fluid. The system is numerically evolved in time using an immersed boundary framework producing an emergent swimming mode. Proprioceptive feedback to the CPG based on experimental observations adjust the activation signal as the organism interacts with its environment. Effects on the speed, stability and cost (metabolic work) of swimming due to nonlinear dependencies associated with muscle force development combined with proprioceptive feedback to neural activation are estimated and examined.

A Model of Leadership in Integrating Educational Technology in Higher Education

ERIC Educational Resources Information Center

Markova, Mariya

2014-01-01

The potential impacts and implications of technology on the professional lives of instructors in higher education, and the role of leadership in integrating educational technology, present a variety of complexities and challenges. The purpose of this paper is to identify the reasons why faculty members are not fully embracing technology and what…

SMAUMAT_ITI

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jannetti, C.; Becker, R.

The software is an ABAQUS/Standard UMAT (user defined material behavior subroutine) that implements the constitutive model for shape-memory alloy materials developed by Jannetti et. al. (2003a) using a fully implicit time integration scheme to integrate the constitutive equations. The UMAT is used in conjunction with ABAQUS/Standard to perform a finite-element analysis of SMA materials.

Biomass and fire dynamics in a temperate forest-grassland mosaic: Integrating multi-species herbivory, climate, and fire with the FireBGCv2/GrazeBGC system

Treesearch

Robert A. Riggs; Robert E. Keane; Norm Cimon; Rachel Cook; Lisa Holsinger; John Cook; Timothy DelCurto; L.Scott Baggett; Donald Justice; David Powell; Martin Vavra; Bridgett Naylor

2015-01-01

Landscape fire succession models (LFSMs) predict spatially-explicit interactions between vegetation succession and disturbance, but these models have yet to fully integrate ungulate herbivory as a driver of their processes. We modified a complex LFSM, FireBGCv2, to include a multi-species herbivory module, GrazeBGC. The system is novel in that it explicitly...

Developing an Experimental Model of Vascular Toxicity in Embryonic Zebrafish

EPA Science Inventory

Developing an Experimental Model of Vascular Toxicity in Embryonic Zebrafish Tamara Tal, Integrated Systems Toxicology Division, U.S. EPA Background: There are tens of thousands of chemicals that have yet to be fully evaluated for their toxicity by validated in vivo testing ...

Development of the Hydrological-Ecological Integrated watershed Flow Model (HEIFLOW): an application to the Heihe River Basin

NASA Astrophysics Data System (ADS)

Tian, Y.; Zheng, Y.; Zheng, C.; Han, F., Sr.

2017-12-01

Physically based and fully-distributed integrated hydrological models (IHMs) can quantitatively depict hydrological processes, both surface and subsurface, with sufficient spatial and temporal details. However, the complexity involved in pre-processing data and setting up models seriously hindered the wider application of IHMs in scientific research and management practice. This study introduces our design and development of Visual HEIFLOW, hereafter referred to as VHF, a comprehensive graphical data processing and modeling system for integrated hydrological simulation. The current version of VHF has been structured to accommodate an IHM named HEIFLOW (Hydrological-Ecological Integrated watershed-scale FLOW model). HEIFLOW is a model being developed by the authors, which has all typical elements of physically based and fully-distributed IHMs. It is based on GSFLOW, a representative integrated surface water-groundwater model developed by USGS. HEIFLOW provides several ecological modules that enable to simulate growth cycle of general vegetation and special plants (maize and populus euphratica). VHF incorporates and streamlines all key steps of the integrated modeling, and accommodates all types of GIS data necessary to hydrological simulation. It provides a GIS-based data processing framework to prepare an IHM for simulations, and has functionalities to flexibly display and modify model features (e.g., model grids, streams, boundary conditions, observational sites, etc.) and their associated data. It enables visualization and various spatio-temporal analyses of all model inputs and outputs at different scales (i.e., computing unit, sub-basin, basin, or user-defined spatial extent). The above system features, as well as many others, can significantly reduce the difficulty and time cost of building and using a complex IHM. The case study in the Heihe River Basin demonstrated the applicability of VHF for large scale integrated SW-GW modeling. Visualization and spatial-temporal analysis of the modeling results by HEIFLOW greatly facilitates our understanding on the complicated hydrologic cycle and relationship among the hydrological and ecological variables in the study area, and provides insights into the regional water resources management.

Development of Fully-Integrated Micromagnetic Actuator Technologies

DTIC Science & Technology

2015-07-13

nonexistent because of certain design and fabrication challenges— primarily the inability to integrate high-performance, permanent - magnet ( magnetically ... efficiency necessary for certain applications. To enable the development of high-performance magnetic actuator technologies, the original research plan...developed permanent - magnet materials in more complex microfabrication process flows Objective 2: Design, model, and optimize a novel multi- magnet

A near-wall turbulence model and its application to fully developed turbulent channel and pipe flows

NASA Technical Reports Server (NTRS)

Kim, S.-W.

1988-01-01

A near wall turbulence model and its incorporation into a multiple-time-scale turbulence model are presented. In the method, the conservation of mass, momentum, and the turbulent kinetic energy equations are integrated up to the wall; and the energy transfer rate and the dissipation rate inside the near wall layer are obtained from algebraic equations. The algebraic equations for the energy transfer rate and the dissipation rate inside the near wall layer were obtained from a k-equation turbulence model and the near wall analysis. A fully developed turbulent channel flow and fully developed turbulent pipe flows were solved using a finite element method to test the predictive capability of the turbulence model. The computational results compared favorably with experimental data. It is also shown that the present turbulence model could resolve the over shoot phenomena of the turbulent kinetic energy and the dissipation rate in the region very close to the wall.

Horses for courses: analytical tools to explore planetary boundaries

NASA Astrophysics Data System (ADS)

van Vuuren, Detlef P.; Lucas, Paul L.; Häyhä, Tiina; Cornell, Sarah E.; Stafford-Smith, Mark

2016-03-01

There is a need for more integrated research on sustainable development and global environmental change. In this paper, we focus on the planetary boundaries framework to provide a systematic categorization of key research questions in relation to avoiding severe global environmental degradation. The four categories of key questions are those that relate to (1) the underlying processes and selection of key indicators for planetary boundaries, (2) understanding the impacts of environmental pressure and connections between different types of impacts, (3) better understanding of different response strategies to avoid further degradation, and (4) the available instruments to implement such strategies. Clearly, different categories of scientific disciplines and associated model types exist that can accommodate answering these questions. We identify the strength and weaknesses of different research areas in relation to the question categories, focusing specifically on different types of models. We discuss that more interdisciplinary research is need to increase our understanding by better linking human drivers and social and biophysical impacts. This requires better collaboration between relevant disciplines (associated with the model types), either by exchanging information or by fully linking or integrating them. As fully integrated models can become too complex, the appropriate type of model (the racehorse) should be applied for answering the target research question (the race course).

Integration of GCAM-USA into GLIMPSE: Update and demonstration

EPA Science Inventory

The purpose of this presentation is to (i) discuss changes made to the GCAM-USA model to more fully support long-term, coordinated environmental-climate-energy planning within the U.S., and (ii) demonstrate the graphical user interface that has been constructed to construct model...

Towards a high resolution, integrated hydrology model of North America.

NASA Astrophysics Data System (ADS)

Maxwell, R. M.; Condon, L. E.

2015-12-01

Recent studies demonstrate feedbacks between groundwater dynamics, overland flow, land surface and vegetation processes, and atmospheric boundary layer development that significantly affect local and regional climate across a range of climatic conditions. Furthermore, the type and distribution of vegetation cover alters land-atmosphere water and energy fluxes, as well as runoff generation and overland flow processes. These interactions can result in significant feedbacks on local and regional climate. In mountainous regions, recent research has shown that spatial and temporal variability in annual evapotranspiration, and thus water budgets, is strongly dependent on lateral groundwater flow; however, the full effects of these feedbacks across varied terrain (e.g. from plains to mountains) are not well understood. Here, we present a high-resolution, integrated hydrology model that covers much of continental North America and encompasses the Mississippi and Colorado watersheds. The model is run in a fully-transient manner at hourly temporal resolution incorporating fully-coupled land energy states and fluxes with integrated surface and subsurface hydrology. Connections are seen between hydrologic variables (such as water table depth) and land energy fluxes (such as latent heat) and spatial and temporal scaling is shown to span many orders of magnitude. Using these transient simulations as a proof of concept, we present a vision for future integrated simulation capabilities.

Socializing Giftedness: Toward an ACCEL-S Approach

ERIC Educational Resources Information Center

Glaveanu, Vlad P.; Kaufman, James C.

2017-01-01

In this response, we commend Sternberg's Active Concerned Citizenship and Ethical Leadership (ACCEL) model yet urge him to consider an ACCEL-S model that more fully incorporates society's integrative role in giftedness. ACCEL-S builds on the highly complex and contextual view of giftedness proposed by Sternberg and transforms it into a…

An Integrated Performance-Based Budgeting Model for Thai Higher Education

ERIC Educational Resources Information Center

Charoenkul, Nantarat; Siribanpitak, Pruet

2012-01-01

This research mainly aims to develop an administrative model of performance-based budgeting for autonomous state universities. The sample population in this study covers 4 representatives of autonomous state universities from 4 regions of Thailand, where the performance-based budgeting system has been fully practiced. The research informants…

Managing the physics of the economics of integrated health care.

PubMed

Zismer, Daniel K; Werner, Mark J

2012-01-01

The physics metaphor, as applied to the economics (and financial performance) of the integrated health system, seems appropriate when considered together with the nine principles of management framework provided. The nature of the integrated design enhances leaders' management potential as they consider organizational operations and strategy in the markets ahead. One question begged by this argument for the integrated design is the durability, efficiency and ultimate long-term survivability of the more "traditional" community health care delivery models, which, by design, are fragmented, internally competitive and less capital efficient. They also cannot exploit the leverage of teams, optimal access management or the pursuit of revenues made available in many forms. For those who wish to move from the traditional to the more integrated community health system designs (especially those who have not yet started the journey), the path requires: * Sufficient balance sheet capacity to fund the integration process-especially as the model requires physician practice acquisitions and electronic health record implementations * A well-prepared board13, 14 * A functional, durable and sustainable physician services enterprise design * A redesigned organizational and governance structure * Favorable internal financial incentives alignment design * Effective accountable physician leadership * Awareness that the system is not solely a funding strategy for acquired physicians, rather a fully -.. committed clinical and business model, one in which patient-centered integrated care is the core service (and not acute care hospital-based services) A willingness to create and exploit the implied and inherent potential of an integrated design and unified brand Last, it's important to remember that an integrated health system is a tool that creates a "new potential" (a physics metaphor reference, one last time). The design doesn't operate itself. Application of the management principles presented here are necessary as a complete recipe. Leaders of health systems moving toward integration are cautioned to apply the recipe in full. This article ends with two questions. First, if not an integrated model of health care, what's the alternative? Since it seems clear that many of the existing community-based models are excessively fragmented and inefficient, especially in a reforming U.S. health care marketplace, is there a new model that is superior to the integrated models and, if so, what is it and what are its functional principles? The second question: Is there more than one functional form of integration? This article argues for the most integrated form. Others would argue that clinical integration is sufficient,'s and full integration isn't required. The stability, durability and adaptability of the fully integrated models have, arguably, been tested. The lesser integrated models remain to be proven in an unstable health care marketplace seeking higher levels of economic efficiency.

Partially chaotic orbits in a perturbed cubic force model

NASA Astrophysics Data System (ADS)

Muzzio, J. C.

2017-11-01

Three types of orbits are theoretically possible in autonomous Hamiltonian systems with 3 degrees of freedom: fully chaotic (they only obey the energy integral), partially chaotic (they obey an additional isolating integral besides energy) and regular (they obey two isolating integrals besides energy). The existence of partially chaotic orbits has been denied by several authors, however, arguing either that there is a sudden transition from regularity to full chaoticity or that a long enough follow-up of a supposedly partially chaotic orbit would reveal a fully chaotic nature. This situation needs clarification, because partially chaotic orbits might play a significant role in the process of chaotic diffusion. Here we use numerically computed Lyapunov exponents to explore the phase space of a perturbed three-dimensional cubic force toy model, and a generalization of the Poincaré maps to show that partially chaotic orbits are actually present in that model. They turn out to be double orbits joined by a bifurcation zone, which is the most likely source of their chaos, and they are encapsulated in regions of phase space bounded by regular orbits similar to each one of the components of the double orbit.

Multi-Physics Demonstration Problem with the SHARP Reactor Simulation Toolkit

DOE Office of Scientific and Technical Information (OSTI.GOV)

Merzari, E.; Shemon, E. R.; Yu, Y. Q.

This report describes to employ SHARP to perform a first-of-a-kind analysis of the core radial expansion phenomenon in an SFR. This effort required significant advances in the framework Multi-Physics Demonstration Problem with the SHARP Reactor Simulation Toolkit used to drive the coupled simulations, manipulate the mesh in response to the deformation of the geometry, and generate the necessary modified mesh files. Furthermore, the model geometry is fairly complex, and consistent mesh generation for the three physics modules required significant effort. Fully-integrated simulations of a 7-assembly mini-core test problem have been performed, and the results are presented here. Physics models ofmore » a full-core model of the Advanced Burner Test Reactor have also been developed for each of the three physics modules. Standalone results of each of the three physics modules for the ABTR are presented here, which provides a demonstration of the feasibility of the fully-integrated simulation.« less

Fully Associative, Nonisothermal, Potential-Based Unified Viscoplastic Model for Titanium-Based Matrices

NASA Technical Reports Server (NTRS)

2005-01-01

A number of titanium matrix composite (TMC) systems are currently being investigated for high-temperature air frame and propulsion system applications. As a result, numerous computational methodologies for predicting both deformation and life for this class of materials are under development. An integral part of these methodologies is an accurate and computationally efficient constitutive model for the metallic matrix constituent. Furthermore, because these systems are designed to operate at elevated temperatures, the required constitutive models must account for both time-dependent and time-independent deformations. To accomplish this, the NASA Lewis Research Center is employing a recently developed, complete, potential-based framework. This framework, which utilizes internal state variables, was put forth for the derivation of reversible and irreversible constitutive equations. The framework, and consequently the resulting constitutive model, is termed complete because the existence of the total (integrated) form of the Gibbs complementary free energy and complementary dissipation potentials are assumed a priori. The specific forms selected here for both the Gibbs and complementary dissipation potentials result in a fully associative, multiaxial, nonisothermal, unified viscoplastic model with nonlinear kinematic hardening. This model constitutes one of many models in the Generalized Viscoplasticity with Potential Structure (GVIPS) class of inelastic constitutive equations.

Searches for third-generation squark production in fully hadronic final states in proton-proton collisions at $$ \\sqrt{s} = 8$$ TeV

DOE PAGES

Khachatryan, Vardan

2015-06-17

We searched for third-generation squarks in fully hadronic final states and presented them using data samples corresponding to integrated luminosities of 19.4 or 19.7 fb -1, collected at a centre-of-mass energy of 8 TeV with the CMS detector at the LHC. Three mutually exclusive searches are presented, each optimized for a different decay topology. They include a multijet search requiring one fully reconstructed top quark, a dijet search requiring one or two jets originating from b quarks, and a monojet search. Furthermore, no excesses above the standard model expectations are seen, and limits are set on top and bottom squarkmore » production in the context of simplified models of supersymmetry.« less

Integrated Evaluation of Reliability and Power Consumption of Wireless Sensor Networks.

PubMed

Dâmaso, Antônio; Rosa, Nelson; Maciel, Paulo

2017-11-05

Power consumption is a primary interest in Wireless Sensor Networks (WSNs), and a large number of strategies have been proposed to evaluate it. However, those approaches usually neither consider reliability issues nor the power consumption of applications executing in the network. A central concern is the lack of consolidated solutions that enable us to evaluate the power consumption of applications and the network stack also considering their reliabilities. To solve this problem, we introduce a fully automatic solution to design power consumption aware WSN applications and communication protocols. The solution presented in this paper comprises a methodology to evaluate the power consumption based on the integration of formal models, a set of power consumption and reliability models, a sensitivity analysis strategy to select WSN configurations and a toolbox named EDEN to fully support the proposed methodology. This solution allows accurately estimating the power consumption of WSN applications and the network stack in an automated way.

Near-wall turbulence model and its application to fully developed turbulent channel and pipe flows

NASA Technical Reports Server (NTRS)

Kim, S.-W.

1990-01-01

A near-wall turbulence model and its incorporation into a multiple-timescale turbulence model are presented. The near-wall turbulence model is obtained from a k-equation turbulence model and a near-wall analysis. In the method, the equations for the conservation of mass, momentum, and turbulent kinetic energy are integrated up to the wall, and the energy transfer and the dissipation rates inside the near-wall layer are obtained from algebraic equations. Fully developed turbulent channel and pipe flows are solved using a finite element method. The computational results compare favorably with experimental data. It is also shown that the turbulence model can resolve the overshoot phenomena of the turbulent kinetic energy and the dissipation rate in the region very close to the wall.

Improving Learning for All Students through Equity-Based Inclusive Reform Practices: Effectiveness of a Fully Integrated Schoolwide Model on Student Reading and Math Achievement

ERIC Educational Resources Information Center

Choi, Jeong Hoon; Meisenheimer, Jessica M.; McCart, Amy B.; Sailor, Wayne

2017-01-01

The present investigation examines the schoolwide applications model (SAM) as a potentially effective school reform model for increasing equity-based inclusive education practices while enhancing student reading and math achievement for all students. A 3-year quasi-experimental comparison group analysis using latent growth modeling (LGM) was used…

STS/DBS power subsystem end-to-end stability margin

NASA Astrophysics Data System (ADS)

Devaux, R. N.; Vattimo, R. J.; Peck, S. R.; Baker, W. E.

Attention is given to a full-up end-to-end subsystem stability test which was performed with a flight solar array providing power to a fully operational spacecraft. The solar array simulator is described, and a comparison is made between test results obtained with the simulator and those obtained with the actual array. It is concluded that stability testing with a fully integrated spacecraft is necessary to ensure that all elements have been adequately modeled.

Flight evaluation of differential GPS aided inertial navigation systems

NASA Technical Reports Server (NTRS)

Mcnally, B. David; Paielli, Russell A.; Bach, Ralph E., Jr.; Warner, David N., Jr.

1992-01-01

Algorithms are described for integration of Differential Global Positioning System (DGPS) data with Inertial Navigation System (INS) data to provide an integrated DGPS/INS navigation system. The objective is to establish the benefits that can be achieved through various levels of integration of DGPS with INS for precision navigation. An eight state Kalman filter integration was implemented in real-time on a twin turbo-prop transport aircraft to evaluate system performance during terminal approach and landing operations. A fully integrated DGPS/INS system is also presented which models accelerometer and rate-gyro measurement errors plus position, velocity, and attitude errors. The fully integrated system was implemented off-line using range-domain (seventeen-state) and position domain (fifteen-state) Kalman filters. Both filter integration approaches were evaluated using data collected during the flight test. Flight-test data consisted of measurements from a 5 channel Precision Code GPS receiver, a strap-down Inertial Navigation Unit (INU), and GPS satellite differential range corrections from a ground reference station. The aircraft was laser tracked to determine its true position. Results indicate that there is no significant improvement in positioning accuracy with the higher levels of DGPS/INS integration. All three systems provided high-frequency (e.g., 20 Hz) estimates of position and velocity. The fully integrated system provided estimates of inertial sensor errors which may be used to improve INS navigation accuracy should GPS become unavailable, and improved estimates of acceleration, attitude, and body rates which can be used for guidance and control. Precision Code DGPS/INS positioning accuracy (root-mean-square) was 1.0 m cross-track and 3.0 m vertical. (This AGARDograph was sponsored by the Guidance and Control Panel.)

Towards a high resolution, integrated hydrology model of North America: Diagnosis of feedbacks between groundwater and land energy fluxes at continental scales.

NASA Astrophysics Data System (ADS)

Maxwell, Reed; Condon, Laura

2016-04-01

Recent studies demonstrate feedbacks between groundwater dynamics, overland flow, land surface and vegetation processes, and atmospheric boundary layer development that significantly affect local and regional climate across a range of climatic conditions. Furthermore, the type and distribution of vegetation cover alters land-atmosphere water and energy fluxes, as well as runoff generation and overland flow processes. These interactions can result in significant feedbacks on local and regional climate. In mountainous regions, recent research has shown that spatial and temporal variability in annual evapotranspiration, and thus water budgets, is strongly dependent on lateral groundwater flow; however, the full effects of these feedbacks across varied terrain (e.g. from plains to mountains) are not well understood. Here, we present a high-resolution, integrated hydrology model that covers much of continental North America and encompasses the Mississippi and Colorado watersheds. The model is run in a fully-transient manner at hourly temporal resolution incorporating fully-coupled land energy states and fluxes with integrated surface and subsurface hydrology. Connections are seen between hydrologic variables (such as water table depth) and land energy fluxes (such as latent heat) and spatial and temporal scaling is shown to span many orders of magnitude. Model results suggest that partitioning of plant transpiration to bare soil evaporation is a function of water table depth and later groundwater flow. Using these transient simulations as a proof of concept, we present a vision for future integrated simulation capabilities.

New approach for optimal electricity planning and dispatching with hourly time-scale air quality and health considerations.

PubMed

Kerl, Paul Y; Zhang, Wenxian; Moreno-Cruz, Juan B; Nenes, Athanasios; Realff, Matthew J; Russell, Armistead G; Sokol, Joel; Thomas, Valerie M

2015-09-01

Integrating accurate air quality modeling with decision making is hampered by complex atmospheric physics and chemistry and its coupling with atmospheric transport. Existing approaches to model the physics and chemistry accurately lead to significant computational burdens in computing the response of atmospheric concentrations to changes in emissions profiles. By integrating a reduced form of a fully coupled atmospheric model within a unit commitment optimization model, we allow, for the first time to our knowledge, a fully dynamical approach toward electricity planning that accurately and rapidly minimizes both cost and health impacts. The reduced-form model captures the response of spatially resolved air pollutant concentrations to changes in electricity-generating plant emissions on an hourly basis with accuracy comparable to a comprehensive air quality model. The integrated model allows for the inclusion of human health impacts into cost-based decisions for power plant operation. We use the new capability in a case study of the state of Georgia over the years of 2004-2011, and show that a shift in utilization among existing power plants during selected hourly periods could have provided a health cost savings of $175.9 million dollars for an additional electricity generation cost of $83.6 million in 2007 US dollars (USD2007). The case study illustrates how air pollutant health impacts can be cost-effectively minimized by intelligently modulating power plant operations over multihour periods, without implementing additional emissions control technologies.

New approach for optimal electricity planning and dispatching with hourly time-scale air quality and health considerations

PubMed Central

Kerl, Paul Y.; Zhang, Wenxian; Moreno-Cruz, Juan B.; Nenes, Athanasios; Realff, Matthew J.; Russell, Armistead G.; Sokol, Joel; Thomas, Valerie M.

2015-01-01

Integrating accurate air quality modeling with decision making is hampered by complex atmospheric physics and chemistry and its coupling with atmospheric transport. Existing approaches to model the physics and chemistry accurately lead to significant computational burdens in computing the response of atmospheric concentrations to changes in emissions profiles. By integrating a reduced form of a fully coupled atmospheric model within a unit commitment optimization model, we allow, for the first time to our knowledge, a fully dynamical approach toward electricity planning that accurately and rapidly minimizes both cost and health impacts. The reduced-form model captures the response of spatially resolved air pollutant concentrations to changes in electricity-generating plant emissions on an hourly basis with accuracy comparable to a comprehensive air quality model. The integrated model allows for the inclusion of human health impacts into cost-based decisions for power plant operation. We use the new capability in a case study of the state of Georgia over the years of 2004–2011, and show that a shift in utilization among existing power plants during selected hourly periods could have provided a health cost savings of $175.9 million dollars for an additional electricity generation cost of $83.6 million in 2007 US dollars (USD2007). The case study illustrates how air pollutant health impacts can be cost-effectively minimized by intelligently modulating power plant operations over multihour periods, without implementing additional emissions control technologies. PMID:26283358

Integrated surface-subsurface model to investigate the role of groundwater in headwater catchment runoff generation: A minimalist approach to parameterisation

NASA Astrophysics Data System (ADS)

Ala-aho, Pertti; Soulsby, Chris; Wang, Hailong; Tetzlaff, Doerthe

2017-04-01

Understanding the role of groundwater for runoff generation in headwater catchments is a challenge in hydrology, particularly so in data-scarce areas. Fully-integrated surface-subsurface modelling has shown potential in increasing process understanding for runoff generation, but high data requirements and difficulties in model calibration are typically assumed to preclude their use in catchment-scale studies. We used a fully integrated surface-subsurface hydrological simulator to enhance groundwater-related process understanding in a headwater catchment with a rich background in empirical data. To set up the model we used minimal data that could be reasonably expected to exist for any experimental catchment. A novel aspect of our approach was in using simplified model parameterisation and including parameters from all model domains (surface, subsurface, evapotranspiration) in automated model calibration. Calibration aimed not only to improve model fit, but also to test the information content of the observations (streamflow, remotely sensed evapotranspiration, median groundwater level) used in calibration objective functions. We identified sensitive parameters in all model domains (subsurface, surface, evapotranspiration), demonstrating that model calibration should be inclusive of parameters from these different model domains. Incorporating groundwater data in calibration objectives improved the model fit for groundwater levels, but simulations did not reproduce well the remotely sensed evapotranspiration time series even after calibration. Spatially explicit model output improved our understanding of how groundwater functions in maintaining streamflow generation primarily via saturation excess overland flow. Steady groundwater inputs created saturated conditions in the valley bottom riparian peatlands, leading to overland flow even during dry periods. Groundwater on the hillslopes was more dynamic in its response to rainfall, acting to expand the saturated area extent and thereby promoting saturation excess overland flow during rainstorms. Our work shows the potential of using integrated surface-subsurface modelling alongside with rigorous model calibration to better understand and visualise the role of groundwater in runoff generation even with limited datasets.

Ontological modelling of knowledge management for human-machine integrated design of ultra-precision grinding machine

NASA Astrophysics Data System (ADS)

Hong, Haibo; Yin, Yuehong; Chen, Xing

2016-11-01

Despite the rapid development of computer science and information technology, an efficient human-machine integrated enterprise information system for designing complex mechatronic products is still not fully accomplished, partly because of the inharmonious communication among collaborators. Therefore, one challenge in human-machine integration is how to establish an appropriate knowledge management (KM) model to support integration and sharing of heterogeneous product knowledge. Aiming at the diversity of design knowledge, this article proposes an ontology-based model to reach an unambiguous and normative representation of knowledge. First, an ontology-based human-machine integrated design framework is described, then corresponding ontologies and sub-ontologies are established according to different purposes and scopes. Second, a similarity calculation-based ontology integration method composed of ontology mapping and ontology merging is introduced. The ontology searching-based knowledge sharing method is then developed. Finally, a case of human-machine integrated design of a large ultra-precision grinding machine is used to demonstrate the effectiveness of the method.

Cold Helium Pressurization for Liquid Oxygen/Liquid Methane Propulsion Systems: Fully-Integrated Hot-Fire Test Results

NASA Technical Reports Server (NTRS)

Morehead, R. L.; Atwell, M. J.; Melcher, J. C.; Hurlbert, E. A.

2016-01-01

Hot-fire test demonstrations were successfully conducted using a cold helium pressurization system fully integrated into a liquid oxygen (LOX) / liquid methane (LCH4) propulsion system (Figure 1). Cold helium pressurant storage at near liquid nitrogen (LN2) temperatures (-275 F and colder) and used as a heated tank pressurant provides a substantial density advantage compared to ambient temperature storage. The increased storage density reduces helium pressurant tank size and mass, creating payload increases of 35% for small lunar-lander sized applications. This degree of mass reduction also enables pressure-fed propulsion systems for human-rated Mars ascent vehicle designs. Hot-fire test results from the highly-instrumented test bed will be used to demonstrate system performance and validate integrated models of the helium and propulsion systems. A pressurization performance metric will also be developed as a means to compare different active pressurization schemes.

Nonlinear interaction between underwater explosion bubble and structure based on fully coupled model

NASA Astrophysics Data System (ADS)

Zhang, A. M.; Wu, W. B.; Liu, Y. L.; Wang, Q. X.

2017-08-01

The interaction between an underwater explosion bubble and an elastic-plastic structure is a complex transient process, accompanying violent bubble collapsing, jet impact, penetration through the bubble, and large structural deformation. In the present study, the bubble dynamics are modeled using the boundary element method and the nonlinear transient structural response is modeled using the explicit finite element method. A new fully coupled 3D model is established through coupling the equations for the state variables of the fluid and structure and solving them as a set of coupled linear algebra equations. Based on the acceleration potential theory, the mutual dependence between the hydrodynamic load and the structural motion is decoupled. The pressure distribution in the flow field is calculated with the Bernoulli equation, where the partial derivative of the velocity potential in time is calculated using the boundary integral method to avoid numerical instabilities. To validate the present fully coupled model, the experiments of small-scale underwater explosion near a stiffened plate are carried out. High-speed imaging is used to capture the bubble behaviors and strain gauges are used to measure the strain response. The numerical results correspond well with the experimental data, in terms of bubble shapes and structural strain response. By both the loosely coupled model and the fully coupled model, the interaction between a bubble and a hollow spherical shell is studied. The bubble patterns vary with different parameters. When the fully coupled model and the loosely coupled model are advanced with the same time step, the error caused by the loosely coupled model becomes larger with the coupling effect becoming stronger. The fully coupled model is more stable than the loosely coupled model. Besides, the influences of the internal fluid on the dynamic response of the spherical shell are studied. At last, the case that the bubble interacts with an air-backed stiffened plate is simulated. The associated interesting physical phenomenon is obtained and expounded.

A 3D THz image processing methodology for a fully integrated, semi-automatic and near real-time operational system

NASA Astrophysics Data System (ADS)

Brook, A.; Cristofani, E.; Vandewal, M.; Matheis, C.; Jonuscheit, J.; Beigang, R.

2012-05-01

The present study proposes a fully integrated, semi-automatic and near real-time mode-operated image processing methodology developed for Frequency-Modulated Continuous-Wave (FMCW) THz images with the center frequencies around: 100 GHz and 300 GHz. The quality control of aeronautics composite multi-layered materials and structures using Non-Destructive Testing is the main focus of this work. Image processing is applied on the 3-D images to extract useful information. The data is processed by extracting areas of interest. The detected areas are subjected to image analysis for more particular investigation managed by a spatial model. Finally, the post-processing stage examines and evaluates the spatial accuracy of the extracted information.

Numerical and experimental analysis of a ducted propeller designed by a fully automated optimization process under open water condition

NASA Astrophysics Data System (ADS)

Yu, Long; Druckenbrod, Markus; Greve, Martin; Wang, Ke-qi; Abdel-Maksoud, Moustafa

2015-10-01

A fully automated optimization process is provided for the design of ducted propellers under open water conditions, including 3D geometry modeling, meshing, optimization algorithm and CFD analysis techniques. The developed process allows the direct integration of a RANSE solver in the design stage. A practical ducted propeller design case study is carried out for validation. Numerical simulations and open water tests are fulfilled and proved that the optimum ducted propeller improves hydrodynamic performance as predicted.

An integrated approach to infer dynamic protein-gene interactions - A case study of the human P53 protein.

PubMed

Wang, Junbai; Wu, Qianqian; Hu, Xiaohua Tony; Tian, Tianhai

2016-11-01

Investigating the dynamics of genetic regulatory networks through high throughput experimental data, such as microarray gene expression profiles, is a very important but challenging task. One of the major hindrances in building detailed mathematical models for genetic regulation is the large number of unknown model parameters. To tackle this challenge, a new integrated method is proposed by combining a top-down approach and a bottom-up approach. First, the top-down approach uses probabilistic graphical models to predict the network structure of DNA repair pathway that is regulated by the p53 protein. Two networks are predicted, namely a network of eight genes with eight inferred interactions and an extended network of 21 genes with 17 interactions. Then, the bottom-up approach using differential equation models is developed to study the detailed genetic regulations based on either a fully connected regulatory network or a gene network obtained by the top-down approach. Model simulation error, parameter identifiability and robustness property are used as criteria to select the optimal network. Simulation results together with permutation tests of input gene network structures indicate that the prediction accuracy and robustness property of the two predicted networks using the top-down approach are better than those of the corresponding fully connected networks. In particular, the proposed approach reduces computational cost significantly for inferring model parameters. Overall, the new integrated method is a promising approach for investigating the dynamics of genetic regulation. Copyright © 2016 Elsevier Inc. All rights reserved.

Aircraft Survivability: Aircraft Battle Damage and Repair, Summer 2007

DTIC Science & Technology

2007-01-01

Modeling and Analysis Program ( TMAP ) Missile Modeling System for Advanced Investigation of Countermeasures (MOSAIC) & Joint Surface-to-Air Missle... TMAP Threat System Models (TSM) into engagement simulations (MOSAIC [IR] and JSAMS [RF]). This 3-year project will integrate and fully test six...three per engagement simulation) JASC priority TMAP TSMs in official releases of MOSAIC and JSAMS. Project Engineers— Luke Borntrager (USAF, AFRL) and

A fully coupled variable properties thermohydraulic model for a cryogenic hydrostatic journal bearing

NASA Technical Reports Server (NTRS)

Braun, M. J.; Wheeler, R. L., III; Hendricks, R. C.

1986-01-01

The goal set forth here is to continue the work started by Braun et al. (1984-1985) and present an integrated analysis of the behavior of the two row, 20 staggered pockets, hydrostatic cryogenic bearing used by the turbopumps of the Space Shuttle main engine. The variable properties Reynolds equation is fully coupled with the two-dimensional fluid film energy equation. The three-dimensional equations of the shaft and bushing model the boundary conditions of the fluid film energy equation. The effects of shaft eccentricity, angular velocity, and inertia pressure drops at pocket edge are incorporated in the model. Their effects on the bearing fluid properties, load carrying capacity, mass flow, pressure, velocity, and temperature form the ultimate object of this paper.

Integrating Health and Mental Health Services: A Past and Future History.

PubMed

Druss, Benjamin G; Goldman, Howard H

2018-04-25

The authors trace the modern history, current landscape, and future prospects for integration between mental health and general medical care in the United States. Research and new treatment models developed in the 1980s and early 1990s helped inform federal legislation, including the 2008 Mental Health Parity and Addiction Equity Act and the 2010 Affordable Care Act, which in turn are creating new opportunities to further integrate services. Future efforts should build on this foundation to develop clinical, service-level, and public health approaches that more fully integrate mental, medical, substance use, and social services.

The Magnetic Reconnection Code: an AMR-based fully implicit simulation suite

NASA Astrophysics Data System (ADS)

Germaschewski, K.; Bhattacharjee, A.; Ng, C.-S.

2006-12-01

Extended MHD models, which incorporate two-fluid effects, are promising candidates to enhance understanding of collisionless reconnection phenomena in laboratory, space and astrophysical plasma physics. In this paper, we introduce two simulation codes in the Magnetic Reconnection Code suite which integrate reduced and full extended MHD models. Numerical integration of these models comes with two challenges: Small-scale spatial structures, e.g. thin current sheets, develop and must be well resolved by the code. Adaptive mesh refinement (AMR) is employed to provide high resolution where needed while maintaining good performance. Secondly, the two-fluid effects in extended MHD give rise to dispersive waves, which lead to a very stringent CFL condition for explicit codes, while reconnection happens on a much slower time scale. We use a fully implicit Crank--Nicholson time stepping algorithm. Since no efficient preconditioners are available for our system of equations, we instead use a direct solver to handle the inner linear solves. This requires us to actually compute the Jacobian matrix, which is handled by a code generator that calculates the derivative symbolically and then outputs code to calculate it.

Closed-form solutions in stress-driven two-phase integral elasticity for bending of functionally graded nano-beams

NASA Astrophysics Data System (ADS)

Barretta, Raffaele; Fabbrocino, Francesco; Luciano, Raimondo; Sciarra, Francesco Marotti de

2018-03-01

Strain-driven and stress-driven integral elasticity models are formulated for the analysis of the structural behaviour of fuctionally graded nano-beams. An innovative stress-driven two-phases constitutive mixture defined by a convex combination of local and nonlocal phases is presented. The analysis reveals that the Eringen strain-driven fully nonlocal model cannot be used in Structural Mechanics since it is ill-posed and the local-nonlocal mixtures based on the Eringen integral model partially resolve the ill-posedeness of the model. In fact, a singular behaviour of continuous nano-structures appears if the local fraction tends to vanish so that the ill-posedness of the Eringen integral model is not eliminated. On the contrary, local-nonlocal mixtures based on the stress-driven theory are mathematically and mechanically appropriate for nanosystems. Exact solutions of inflected functionally graded nanobeams of technical interest are established by adopting the new local-nonlocal mixture stress-driven integral relation. Effectiveness of the new nonlocal approach is tested by comparing the contributed results with the ones corresponding to the mixture Eringen theory.

Integrated Evaluation of Reliability and Power Consumption of Wireless Sensor Networks

PubMed Central

Dâmaso, Antônio; Maciel, Paulo

2017-01-01

Power consumption is a primary interest in Wireless Sensor Networks (WSNs), and a large number of strategies have been proposed to evaluate it. However, those approaches usually neither consider reliability issues nor the power consumption of applications executing in the network. A central concern is the lack of consolidated solutions that enable us to evaluate the power consumption of applications and the network stack also considering their reliabilities. To solve this problem, we introduce a fully automatic solution to design power consumption aware WSN applications and communication protocols. The solution presented in this paper comprises a methodology to evaluate the power consumption based on the integration of formal models, a set of power consumption and reliability models, a sensitivity analysis strategy to select WSN configurations and a toolbox named EDEN to fully support the proposed methodology. This solution allows accurately estimating the power consumption of WSN applications and the network stack in an automated way. PMID:29113078

Modeling the Energy Use of a Connected and Automated Transportation System (Poster)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gonder, J.; Brown, A.

Early research points to large potential impacts of connected and automated vehicles (CAVs) on transportation energy use - dramatic savings, increased use, or anything in between. Due to a lack of suitable data and integrated modeling tools to explore these complex future systems, analyses to date have relied on simple combinations of isolated effects. This poster proposes a framework for modeling the potential energy implications from increasing penetration of CAV technologies and for assessing technology and policy options to steer them toward favorable energy outcomes. Current CAV modeling challenges include estimating behavior change, understanding potential vehicle-to-vehicle interactions, and assessing trafficmore » flow and vehicle use under different automation scenarios. To bridge these gaps and develop a picture of potential future automated systems, NREL is integrating existing modeling capabilities with additional tools and data inputs to create a more fully integrated CAV assessment toolkit.« less

A National Coordinating Center for Trauma Research

DTIC Science & Technology

2016-10-01

of ketamine during the first three days following injury has a sustained effect on reducing the incidence or severity of Post -Traumatic Stress... design , medical modeling, physical modeling, engineering and system integration. Progress Reported: The subcontract was fully executed on 05...were posted on the NTI website (www.nationaltraumainstitute.org). The goal is to comprehensively disseminate published works to the wider trauma

Impact of Media Richness and Flow on E-Learning Technology Acceptance

ERIC Educational Resources Information Center

Liu, Su-Houn; Liao, Hsiu-Li; Pratt, Jean A.

2009-01-01

Advances in e-learning technologies parallels a general increase in sophistication by computer users. The use of just one theory or model, such as the technology acceptance model, is no longer sufficient to study the intended use of e-learning systems. Rather, a combination of theories must be integrated in order to fully capture the complexity of…

Automated Welding System

NASA Technical Reports Server (NTRS)

Bayless, E. O.; Lawless, K. G.; Kurgan, C.; Nunes, A. C.; Graham, B. F.; Hoffman, D.; Jones, C. S.; Shepard, R.

1993-01-01

Fully automated variable-polarity plasma arc VPPA welding system developed at Marshall Space Flight Center. System eliminates defects caused by human error. Integrates many sensors with mathematical model of the weld and computer-controlled welding equipment. Sensors provide real-time information on geometry of weld bead, location of weld joint, and wire-feed entry. Mathematical model relates geometry of weld to critical parameters of welding process.

Compressive failure modes and parameter optimization of the trabecular structure of biomimetic fully integrated honeycomb plates.

PubMed

Chen, Jinxiang; Tuo, Wanyong; Zhang, Xiaoming; He, Chenglin; Xie, Juan; Liu, Chang

2016-12-01

To develop lightweight biomimetic composite structures, the compressive failure and mechanical properties of fully integrated honeycomb plates were investigated experimentally and through the finite element method. The results indicated that: fracturing of the fully integrated honeycomb plates primarily occurred in the core layer, including the sealing edge structure. The morphological failures can be classified into two types, namely dislocations and compactions, and were caused primarily by the stress concentrations at the interfaces between the core layer and the upper and lower laminations and secondarily by the disordered short-fiber distribution in the material; although the fully integrated honeycomb plates manufactured in this experiment were imperfect, their mass-specific compressive strength was superior to that of similar biomimetic samples. Therefore, the proposed bio-inspired structure possesses good overall mechanical properties, and a range of parameters, such as the diameter of the transition arc, was defined for enhancing the design of fully integrated honeycomb plates and improving their compressive mechanical properties. Copyright © 2016 Elsevier B.V. All rights reserved.

Fully integrated biochip platforms for advanced healthcare.

PubMed

Carrara, Sandro; Ghoreishizadeh, Sara; Olivo, Jacopo; Taurino, Irene; Baj-Rossi, Camilla; Cavallini, Andrea; de Beeck, Maaike Op; Dehollain, Catherine; Burleson, Wayne; Moussy, Francis Gabriel; Guiseppi-Elie, Anthony; De Micheli, Giovanni

2012-01-01

Recent advances in microelectronics and biosensors are enabling developments of innovative biochips for advanced healthcare by providing fully integrated platforms for continuous monitoring of a large set of human disease biomarkers. Continuous monitoring of several human metabolites can be addressed by using fully integrated and minimally invasive devices located in the sub-cutis, typically in the peritoneal region. This extends the techniques of continuous monitoring of glucose currently being pursued with diabetic patients. However, several issues have to be considered in order to succeed in developing fully integrated and minimally invasive implantable devices. These innovative devices require a high-degree of integration, minimal invasive surgery, long-term biocompatibility, security and privacy in data transmission, high reliability, high reproducibility, high specificity, low detection limit and high sensitivity. Recent advances in the field have already proposed possible solutions for several of these issues. The aim of the present paper is to present a broad spectrum of recent results and to propose future directions of development in order to obtain fully implantable systems for the continuous monitoring of the human metabolism in advanced healthcare applications.

Fully Integrated Biochip Platforms for Advanced Healthcare

PubMed Central

Carrara, Sandro; Ghoreishizadeh, Sara; Olivo, Jacopo; Taurino, Irene; Baj-Rossi, Camilla; Cavallini, Andrea; de Beeck, Maaike Op; Dehollain, Catherine; Burleson, Wayne; Moussy, Francis Gabriel; Guiseppi-Elie, Anthony; De Micheli, Giovanni

2012-01-01

Recent advances in microelectronics and biosensors are enabling developments of innovative biochips for advanced healthcare by providing fully integrated platforms for continuous monitoring of a large set of human disease biomarkers. Continuous monitoring of several human metabolites can be addressed by using fully integrated and minimally invasive devices located in the sub-cutis, typically in the peritoneal region. This extends the techniques of continuous monitoring of glucose currently being pursued with diabetic patients. However, several issues have to be considered in order to succeed in developing fully integrated and minimally invasive implantable devices. These innovative devices require a high-degree of integration, minimal invasive surgery, long-term biocompatibility, security and privacy in data transmission, high reliability, high reproducibility, high specificity, low detection limit and high sensitivity. Recent advances in the field have already proposed possible solutions for several of these issues. The aim of the present paper is to present a broad spectrum of recent results and to propose future directions of development in order to obtain fully implantable systems for the continuous monitoring of the human metabolism in advanced healthcare applications. PMID:23112644

Real-Time Hardware-in-the-Loop Simulation of Ares I Launch Vehicle

NASA Technical Reports Server (NTRS)

Tobbe, Patrick; Matras, Alex; Walker, David; Wilson, Heath; Fulton, Chris; Alday, Nathan; Betts, Kevin; Hughes, Ryan; Turbe, Michael

2009-01-01

The Ares Real-Time Environment for Modeling, Integration, and Simulation (ARTEMIS) has been developed for use by the Ares I launch vehicle System Integration Laboratory at the Marshall Space Flight Center. The primary purpose of the Ares System Integration Laboratory is to test the vehicle avionics hardware and software in a hardware - in-the-loop environment to certify that the integrated system is prepared for flight. ARTEMIS has been designed to be the real-time simulation backbone to stimulate all required Ares components for verification testing. ARTE_VIIS provides high -fidelity dynamics, actuator, and sensor models to simulate an accurate flight trajectory in order to ensure realistic test conditions. ARTEMIS has been designed to take advantage of the advances in underlying computational power now available to support hardware-in-the-loop testing to achieve real-time simulation with unprecedented model fidelity. A modular realtime design relying on a fully distributed computing architecture has been implemented.

Nonlinear Dynamic Modeling of a Supersonic Commercial Transport Turbo-Machinery Propulsion System for Aero-Propulso-Servo-Elasticity Research

NASA Technical Reports Server (NTRS)

Connolly, Joseph W.; Kopasakis, George; Carlson, Jan-Renee; Woolwine, Kyle

2015-01-01

This paper covers the development of an integrated nonlinear dynamic model for a variable cycle turbofan engine, supersonic inlet, and convergent-divergent nozzle that can be integrated with an aeroelastic vehicle model to create an overall Aero-Propulso-Servo-Elastic (APSE) modeling tool. The primary focus of this study is to provide a means to capture relevant thrust dynamics of a full supersonic propulsion system by using relatively simple quasi-one dimensional computational fluid dynamics (CFD) methods that will allow for accurate control algorithm development and capture the key aspects of the thrust to feed into an APSE model. Previously, propulsion system component models have been developed and are used for this study of the fully integrated propulsion system. An overview of the methodology is presented for the modeling of each propulsion component, with a focus on its associated coupling for the overall model. To conduct APSE studies the de- scribed dynamic propulsion system model is integrated into a high fidelity CFD model of the full vehicle capable of conducting aero-elastic studies. Dynamic thrust analysis for the quasi-one dimensional dynamic propulsion system model is presented along with an initial three dimensional flow field model of the engine integrated into a supersonic commercial transport.

Nonlinear Dynamic Modeling of a Supersonic Commercial Transport Turbo-Machinery Propulsion System for Aero-Propulso-Servo-Elasticity Research

NASA Technical Reports Server (NTRS)

Connolly, Joe; Carlson, Jan-Renee; Kopasakis, George; Woolwine, Kyle

2015-01-01

This paper covers the development of an integrated nonlinear dynamic model for a variable cycle turbofan engine, supersonic inlet, and convergent-divergent nozzle that can be integrated with an aeroelastic vehicle model to create an overall Aero-Propulso-Servo-Elastic (APSE) modeling tool. The primary focus of this study is to provide a means to capture relevant thrust dynamics of a full supersonic propulsion system by using relatively simple quasi-one dimensional computational fluid dynamics (CFD) methods that will allow for accurate control algorithm development and capture the key aspects of the thrust to feed into an APSE model. Previously, propulsion system component models have been developed and are used for this study of the fully integrated propulsion system. An overview of the methodology is presented for the modeling of each propulsion component, with a focus on its associated coupling for the overall model. To conduct APSE studies the described dynamic propulsion system model is integrated into a high fidelity CFD model of the full vehicle capable of conducting aero-elastic studies. Dynamic thrust analysis for the quasi-one dimensional dynamic propulsion system model is presented along with an initial three dimensional flow field model of the engine integrated into a supersonic commercial transport.

Challenges in Interpreting and Validating Satellite Soil Moisture Information

USDA-ARS?s Scientific Manuscript database

Global soil moisture products are now being generated routinely using microwave-based satellite observing systems. These include the NASA Soil Moisture Active Passive (SMAP) mission. In order to fully exploit these observations they must be integrated with both in situ measurements and model-based e...

From hospital information system components to the medical record and clinical guidelines & protocols.

PubMed

Veloso, M; Estevão, N; Ferreira, P; Rodrigues, R; Costa, C T; Barahona, P

1997-01-01

This paper introduces an ongoing project towards the development of a new generation HIS, aiming at the integration of clinical and administrative information within a common framework. Its design incorporates explicit knowledge about domain objects and professional activities to be processed by the system together with related knowledge management services and act management services. The paper presents the conceptual model of the proposed HIS architecture, that supports a rich and fully integrated patient data model, enabling the implementation of a dynamic electronic patient record tightly coupled with computerised guideline knowledge bases.

Modelling of charged satellite motion in Earth's gravitational and magnetic fields

NASA Astrophysics Data System (ADS)

Abd El-Bar, S. E.; Abd El-Salam, F. A.

2018-05-01

In this work Lagrange's planetary equations for a charged satellite subjected to the Earth's gravitational and magnetic force fields are solved. The Earth's gravity, and magnetic and electric force components are obtained and expressed in terms of orbital elements. The variational equations of orbit with the considered model in Keplerian elements are derived. The solution of the problem in a fully analytical way is obtained. The temporal rate of changes of the orbital elements of the spacecraft are integrated via Lagrange's planetary equations and integrals of the normalized Keplerian motion obtained by Ahmed (Astron. J. 107(5):1900, 1994).

Fully implicit Particle-in-cell algorithms for multiscale plasma simulation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chacon, Luis

The outline of the paper is as follows: Particle-in-cell (PIC) methods for fully ionized collisionless plasmas, explicit vs. implicit PIC, 1D ES implicit PIC (charge and energy conservation, moment-based acceleration), and generalization to Multi-D EM PIC: Vlasov-Darwin model (review and motivation for Darwin model, conservation properties (energy, charge, and canonical momenta), and numerical benchmarks). The author demonstrates a fully implicit, fully nonlinear, multidimensional PIC formulation that features exact local charge conservation (via a novel particle mover strategy), exact global energy conservation (no particle self-heating or self-cooling), adaptive particle orbit integrator to control errors in momentum conservation, and canonical momenta (EM-PICmore » only, reduced dimensionality). The approach is free of numerical instabilities: ω peΔt >> 1, and Δx >> λ D. It requires many fewer dofs (vs. explicit PIC) for comparable accuracy in challenging problems. Significant CPU gains (vs explicit PIC) have been demonstrated. The method has much potential for efficiency gains vs. explicit in long-time-scale applications. Moment-based acceleration is effective in minimizing N FE, leading to an optimal algorithm.« less

Self-Tuning Fully-Connected PID Neural Network System for Distributed Temperature Sensing and Control of Instrument with Multi-Modules.

PubMed

Zhang, Zhen; Ma, Cheng; Zhu, Rong

2016-10-14

High integration of multi-functional instruments raises a critical issue in temperature control that is challenging due to its spatial-temporal complexity. This paper presents a multi-input multi-output (MIMO) self-tuning temperature sensing and control system for efficiently modulating the temperature environment within a multi-module instrument. The smart system ensures that the internal temperature of the instrument converges to a target without the need of a system model, thus making the control robust. The system consists of a fully-connected proportional-integral-derivative (PID) neural network (FCPIDNN) and an on-line self-tuning module. The experimental results show that the presented system can effectively control the internal temperature under various mission scenarios, in particular, it is able to self-reconfigure upon actuator failure. The system provides a new scheme for a complex and time-variant MIMO control system which can be widely applied for the distributed measurement and control of the environment in instruments, integration electronics, and house constructions.

A fully disposable and integrated paper-based device for nucleic acid extraction, amplification and detection.

PubMed

Tang, Ruihua; Yang, Hui; Gong, Yan; You, MinLi; Liu, Zhi; Choi, Jane Ru; Wen, Ting; Qu, Zhiguo; Mei, Qibing; Xu, Feng

2017-03-29

Nucleic acid testing (NAT) has been widely used for disease diagnosis, food safety control and environmental monitoring. At present, NAT mainly involves nucleic acid extraction, amplification and detection steps that heavily rely on large equipment and skilled workers, making the test expensive, time-consuming, and thus less suitable for point-of-care (POC) applications. With advances in paper-based microfluidic technologies, various integrated paper-based devices have recently been developed for NAT, which however require off-chip reagent storage, complex operation steps and equipment-dependent nucleic acid amplification, restricting their use for POC testing. To overcome these challenges, we demonstrate a fully disposable and integrated paper-based sample-in-answer-out device for NAT by integrating nucleic acid extraction, helicase-dependent isothermal amplification and lateral flow assay detection into one paper device. This simple device allows on-chip dried reagent storage and equipment-free nucleic acid amplification with simple operation steps, which could be performed by untrained users in remote settings. The proposed device consists of a sponge-based reservoir and a paper-based valve for nucleic acid extraction, an integrated battery, a PTC ultrathin heater, temperature control switch and on-chip dried enzyme mix storage for isothermal amplification, and a lateral flow test strip for naked-eye detection. It can sensitively detect Salmonella typhimurium, as a model target, with a detection limit of as low as 10 2 CFU ml -1 in wastewater and egg, and 10 3 CFU ml -1 in milk and juice in about an hour. This fully disposable and integrated paper-based device has great potential for future POC applications in resource-limited settings.

Integrating resource selection information with spatial capture--recapture

USGS Publications Warehouse

Royle, J. Andrew; Chandler, Richard B.; Sun, Catherine C.; Fuller, Angela K.

2013-01-01

4. Finally, we find that SCR models using standard symmetric and stationary encounter probability models may not fully explain variation in encounter probability due to space usage, and therefore produce biased estimates of density when animal space usage is related to resource selection. Consequently, it is important that space usage be taken into consideration, if possible, in studies focused on estimating density using capture–recapture methods.

3MRA: A MULTI-MEDIA HUMAN AND ECOLOGICAL MODELING SYSTEM FOR SITE-SPECIFIC TO NATIONAL SCALE REGULATORY APPLICATIONS

EPA Science Inventory

3MRA provides a technology that fully integrates the full dimensionality of human and ecological exposure and risk assessment, thus allowing regulatory decisions a more complete expression of potential adverse health effects related to the disposal and reuse of contaminated waste...

The Shale Hills Sensorium for Embedded Sensors, Simulation, & Visualization: A Prototype for Land-Vegetation-Atmosphere Interactions

NASA Astrophysics Data System (ADS)

Duffy, C.

2008-12-01

The future of environmental observing systems will utilize embedded sensor networks with continuous real- time measurement of hydrologic, atmospheric, biogeochemical, and ecological variables across diverse terrestrial environments. Embedded environmental sensors, benefitting from advances in information sciences, networking technology, materials science, computing capacity, and data synthesis methods, are undergoing revolutionary change. It is now possible to field spatially-distributed, multi-node sensor networks that provide density and spatial coverage previously accessible only via numerical simulation. At the same time, computational tools are advancing rapidly to the point where it is now possible to simulate the physical processes controlling individual parcels of water and solutes through the complete terrestrial water cycle. Our goal for the Penn State Critical Zone Observatory is to apply environmental sensor arrays, integrated hydrologic models, and state-of-the-art visualization deployed and coordinated at a testbed within the Penn State Experimental Forest. The Shale Hills Hydro_Sensorium prototype proposed here is designed to observe land-atmosphere interactions in four-dimensional (space and time). The term Hydro_Sensorium implies the totality of physical sensors, models and visualization tools that allow us to perceive the detailed space and time complexities of the water and energy cycle for a watershed or river basin for all physical states and fluxes (groundwater, soil moisture, temperature, streamflow, latent heat, snowmelt, chemistry, isotopes etc.). This research will ultimately catalyze the study of complex interactions between the land surface, subsurface, biological and atmospheric systems over a broad range of scales. The sensor array would be real-time and fully controllable by remote users for "computational steering" and data fusion. Presently fully-coupled physical models are being developed that link the atmosphere-land-vegetation-subsurface system into a fully-coupled distributed system. During the last 5 years the Penn State Integrated Hydrologic Modeling System has been under development as an open-source community modeling project funded by NSF EAR/GEO and NSF CBET/ENG. PIHM represents a strategy for the formulation and solution of fully-coupled process equations at the watershed and river basin scales, and includes a tightly coupled GIS tool for data handling, domain decomposition, optimal unstructured grid generation, and model parameterization. The sensor and simulation system has the following elements: 1) extensive, spatially-distributed, non- invasive, smart sensor networks to gather massive geologic, hydrologic, and geochemical data; 2) stochastic information fusion methods; 3) spatially-explicit multiphysics models/solutions of the land-vegetation- atmosphere system; and 4) asynchronous, parallel/distributed, adaptive algorithms for rapidly simulating the states of a basin at high resolution, 5) signal processing tools for data mining and parameter estimation, and 6) visualization tools. The prototype proposed sensor array and simulation system proposed here will offer a coherent new approach to environmental predictions with a fully integrated observing system design. We expect that the Shale Hills Hydro_Sensorium may provide the needed synthesis of information and conceptualization necessary to advance predictive understanding in complex hydrologic systems.

An efficient model for coupling structural vibrations with acoustic radiation

NASA Technical Reports Server (NTRS)

Frendi, Abdelkader; Maestrello, Lucio; Ting, LU

1993-01-01

The scattering of an incident wave by a flexible panel is studied. The panel vibration is governed by the nonlinear plate equations while the loading on the panel, which is the pressure difference across the panel, depends on the reflected and transmitted waves. Two models are used to calculate this structural-acoustic interaction problem. One solves the three dimensional nonlinear Euler equations for the flow-field coupled with the plate equations (the fully coupled model). The second uses the linear wave equation for the acoustic field and expresses the load as a double integral involving the panel oscillation (the decoupled model). The panel oscillation governed by a system of integro-differential equations is solved numerically and the acoustic field is then defined by an explicit formula. Numerical results are obtained using the two models for linear and nonlinear panel vibrations. The predictions given by these two models are in good agreement but the computational time needed for the 'fully coupled model' is 60 times longer than that for 'the decoupled model'.

Spectrum of Elementary Excitations in Galilean-Invariant Integrable Models

NASA Astrophysics Data System (ADS)

Petković, Aleksandra; Ristivojevic, Zoran

2018-04-01

The spectrum of elementary excitations in one-dimensional quantum liquids is generically linear at low momenta. It is characterized by the sound velocity that can be related to the ground-state energy. Here we study the spectrum at higher momenta in Galilean-invariant integrable models. Somewhat surprisingly, we show that the spectrum at arbitrary momentum is fully determined by the properties of the ground state. We find general exact relations for the coefficients of several terms in the expansion of the excitation energy at low momenta and arbitrary interaction and express them in terms of the Luttinger liquid parameter. We apply the obtained formulas to the Lieb-Liniger model and obtain several new results.

Review of behavioral health integration in primary care at Baylor Scott and White Healthcare, Central Region

PubMed Central

Fluet, Norman R.; Reis, Michael D.; Stern, Charles H.; Thompson, Alexander W.; Jolly, Gillian A.

2016-01-01

The integration of behavioral health services in primary care has been referred to in many ways, but ultimately refers to common structures and processes. Behavioral health is integrated into primary care because it increases the effectiveness and efficiency of providing care and reduces costs in the care of primary care patients. Reimbursement is one factor, if not the main factor, that determines the level of integration that can be achieved. The federal health reform agenda supports changes that will eventually permit behavioral health to be fully integrated and will allow the health of the population to be the primary target of intervention. In an effort to develop more integrated services at Baylor Scott and White Healthcare, models of integration are reviewed and the advantages and disadvantages of each model are discussed. Recommendations to increase integration include adopting a disease management model with care management, planned guideline-based stepped care, follow-up, and treatment monitoring. Population-based interventions can be completed at the pace of the development of alternative reimbursement methods. The program should be based upon patient-centered medical home standards, and research is needed throughout the program development process. PMID:27034543

Integrated Models of Care for Individuals with Opioid Use Disorder: How Do We Prevent HIV and HCV?

PubMed

Rich, Katherine M; Bia, Joshua; Altice, Frederick L; Feinberg, Judith

2018-05-17

To describe models of integrated and co-located care for opioid use disorder (OUD), hepatitis C (HCV), and HIV. The design and scale-up of multidisciplinary care models that engage, retain, and treat individuals with HIV, HCV, and OUD are critical to preventing continued spread of HIV and HCV. We identified 17 models within primary care (N = 3), HIV specialty care (N = 5), opioid treatment programs (N = 6), transitional clinics (N = 2), and community-based harm reduction programs (N = 1), as well as two emerging models. Key components of such models are the provision of (1) medication-assisted treatment for OUD, (2) HIV and HCV treatment, (3) HIV pre-exposure prophylaxis, and (4) behavioral health services. Research is needed to understand differences in effectiveness between co-located and fully integrated care, combat the deleterious racial and ethnic legacies of the "War on Drugs," and inform the delivery of psychiatric care. Increased access to harm reduction services is crucial.

Predicting nurses' use of healthcare technology using the technology acceptance model: an integrative review.

PubMed

Strudwick, Gillian

2015-05-01

The benefits of healthcare technologies can only be attained if nurses accept and intend to fully use them. One of the most common models utilized to understand user acceptance of technology is the Technology Acceptance Model. This model and modified versions of it have only recently been applied in the healthcare literature among nurse participants. An integrative literature review was conducted on this topic. Ovid/MEDLINE, PubMed, Google Scholar, and CINAHL were searched yielding a total of 982 references. Upon eliminating duplicates and applying the inclusion and exclusion criteria, the review included a total of four dissertations, three symposium proceedings, and 13 peer-reviewed journal articles. These documents were appraised and reviewed. The results show that a modified Technology Acceptance Model with added variables could provide a better explanation of nurses' acceptance of healthcare technology. These added variables to modified versions of the Technology Acceptance Model are discussed, and the studies' methodologies are critiqued. Limitations of the studies included in the integrative review are also examined.

PARALLEL MEASUREMENT AND MODELING OF TRANSPORT IN THE DARHT II BEAMLINE ON ETA II

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chambers, F W; Raymond, B A; Falabella, S

To successfully tune the DARHT II transport beamline requires the close coupling of a model of the beam transport and the measurement of the beam observables as the beam conditions and magnet settings are varied. For the ETA II experiment using the DARHT II beamline components this was achieved using the SUICIDE (Simple User Interface Connecting to an Integrated Data Environment) data analysis environment and the FITS (Fully Integrated Transport Simulation) model. The SUICIDE environment has direct access to the experimental beam transport data at acquisition and the FITS predictions of the transport for immediate comparison. The FITS model ismore » coupled into the control system where it can read magnet current settings for real time modeling. We find this integrated coupling is essential for model verification and the successful development of a tuning aid for the efficient convergence on a useable tune. We show the real time comparisons of simulation and experiment and explore the successes and limitations of this close coupled approach.« less

Integrating Cellular Metabolism into a Multiscale Whole-Body Model

PubMed Central

Krauss, Markus; Schaller, Stephan; Borchers, Steffen; Findeisen, Rolf; Lippert, Jörg; Kuepfer, Lars

2012-01-01

Cellular metabolism continuously processes an enormous range of external compounds into endogenous metabolites and is as such a key element in human physiology. The multifaceted physiological role of the metabolic network fulfilling the catalytic conversions can only be fully understood from a whole-body perspective where the causal interplay of the metabolic states of individual cells, the surrounding tissue and the whole organism are simultaneously considered. We here present an approach relying on dynamic flux balance analysis that allows the integration of metabolic networks at the cellular scale into standardized physiologically-based pharmacokinetic models at the whole-body level. To evaluate our approach we integrated a genome-scale network reconstruction of a human hepatocyte into the liver tissue of a physiologically-based pharmacokinetic model of a human adult. The resulting multiscale model was used to investigate hyperuricemia therapy, ammonia detoxification and paracetamol-induced toxication at a systems level. The specific models simultaneously integrate multiple layers of biological organization and offer mechanistic insights into pathology and medication. The approach presented may in future support a mechanistic understanding in diagnostics and drug development. PMID:23133351

Using Hybrid Techniques for Generating Watershed-scale Flood Models in an Integrated Modeling Framework

NASA Astrophysics Data System (ADS)

Saksena, S.; Merwade, V.; Singhofen, P.

2017-12-01

There is an increasing global trend towards developing large scale flood models that account for spatial heterogeneity at watershed scales to drive the future flood risk planning. Integrated surface water-groundwater modeling procedures can elucidate all the hydrologic processes taking part during a flood event to provide accurate flood outputs. Even though the advantages of using integrated modeling are widely acknowledged, the complexity of integrated process representation, computation time and number of input parameters required have deterred its application to flood inundation mapping, especially for large watersheds. This study presents a faster approach for creating watershed scale flood models using a hybrid design that breaks down the watershed into multiple regions of variable spatial resolution by prioritizing higher order streams. The methodology involves creating a hybrid model for the Upper Wabash River Basin in Indiana using Interconnected Channel and Pond Routing (ICPR) and comparing the performance with a fully-integrated 2D hydrodynamic model. The hybrid approach involves simplification procedures such as 1D channel-2D floodplain coupling; hydrologic basin (HUC-12) integration with 2D groundwater for rainfall-runoff routing; and varying spatial resolution of 2D overland flow based on stream order. The results for a 50-year return period storm event show that hybrid model (NSE=0.87) performance is similar to the 2D integrated model (NSE=0.88) but the computational time is reduced to half. The results suggest that significant computational efficiency can be obtained while maintaining model accuracy for large-scale flood models by using hybrid approaches for model creation.

IDEAS and App Development Internship in Hardware and Software Design

NASA Technical Reports Server (NTRS)

Alrayes, Rabab D.

2016-01-01

In this report, I will discuss the tasks and projects I have completed while working as an electrical engineering intern during the spring semester of 2016 at NASA Kennedy Space Center. In the field of software development, I completed tasks for the G-O Caching Mobile App and the Asbestos Management Information System (AMIS) Web App. The G-O Caching Mobile App was written in HTML, CSS, and JavaScript on the Cordova framework, while the AMIS Web App is written in HTML, CSS, JavaScript, and C# on the AngularJS framework. My goals and objectives on these two projects were to produce an app with an eye-catching and intuitive User Interface (UI), which will attract more employees to participate; to produce a fully-tested, fully functional app which supports workforce engagement and exploration; to produce a fully-tested, fully functional web app that assists technicians working in asbestos management. I also worked in hardware development on the Integrated Display and Environmental Awareness System (IDEAS) wearable technology project. My tasks on this project were focused in PCB design and camera integration. My goals and objectives for this project were to successfully integrate fully functioning custom hardware extenders on the wearable technology headset to minimize the size of hardware on the smart glasses headset for maximum user comfort; to successfully integrate fully functioning camera onto the headset. By the end of this semester, I was able to successfully develop four extender boards to minimize hardware on the headset, and assisted in integrating a fully-functioning camera into the system.

An intermediate-scale model for thermal hydrology in low-relief permafrost-affected landscapes

DOE PAGES

Jan, Ahmad; Coon, Ethan T.; Painter, Scott L.; ...

2017-07-10

Integrated surface/subsurface models for simulating the thermal hydrology of permafrost-affected regions in a warming climate have recently become available, but computational demands of those new process-rich simu- lation tools have thus far limited their applications to one-dimensional or small two-dimensional simulations. We present a mixed-dimensional model structure for efficiently simulating surface/subsurface thermal hydrology in low-relief permafrost regions at watershed scales. The approach replaces a full three-dimensional system with a two-dimensional overland thermal hydrology system and a family of one-dimensional vertical columns, where each column represents a fully coupled surface/subsurface thermal hydrology system without lateral flow. The system is then operatormore » split, sequentially updating the overland flow system without sources and the one-dimensional columns without lateral flows. We show that the app- roach is highly scalable, supports subcycling of different processes, and compares well with the corresponding fully three-dimensional representation at significantly less computational cost. Those advances enable recently developed representations of freezing soil physics to be coupled with thermal overland flow and surface energy balance at scales of 100s of meters. Furthermore developed and demonstrated for permafrost thermal hydrology, the mixed-dimensional model structure is applicable to integrated surface/subsurface thermal hydrology in general.« less

An integrated system for rainfall induced shallow landslides modeling

NASA Astrophysics Data System (ADS)

Formetta, Giuseppe; Capparelli, Giovanna; Rigon, Riccardo; Versace, Pasquale

2014-05-01

Rainfall induced shallow landslides (RISL) cause significant damages involving loss of life and properties. Predict susceptible locations for RISL is a complex task that involves many disciplines: hydrology, geotechnical science, geomorphology, statistic. Usually to accomplish this task two main approaches are used: statistical or physically based model. In this work an open source (OS), 3-D, fully distributed hydrological model was integrated in an OS modeling framework (Object Modeling System). The chain is closed by linking the system to a component for safety factor computation with infinite slope approximation able to take into account layered soils and suction contribution to hillslope stability. The model composition was tested for a case study in Calabria (Italy) in order to simulate the triggering of a landslide happened in the Cosenza Province. The integration in OMS allows the use of other components such as a GIS to manage inputs-output processes, and automatic calibration algorithms to estimate model parameters. Finally, model performances were quantified by comparing modelled and simulated trigger time. This research is supported by Ambito/Settore AMBIENTE E SICUREZZA (PON01_01503) project.

On determination of charge transfer efficiency of thick, fully depleted CCDs with 55 Fe x-rays

DOE PAGES

Yates, D.; Kotov, I.; Nomerotski, A.

2017-07-01

Charge transfer efficiency (CTE) is one of the most important CCD characteristics. Our paper examines ways to optimize the algorithms used to analyze 55Fe x-ray data on the CCDs, as well as explores new types of observables for CTE determination that can be used for testing LSST CCDs. Furthermore, the observables are modeled employing simple Monte Carlo simulations to determine how the charge diffusion in thick, fully depleted silicon affects the measurement. The data is compared to the simulations for one of the observables, integral flux of the x-ray hit.

Making School and Community Recreation Fun for Everyone: Places and Ways To Integrate.

ERIC Educational Resources Information Center

Moon, M. Sherril, Ed.

This text offers case studies, models, and specific techniques to assist children, teenagers, and adults with disabilities to participate more fully in local school and neighborhood social and leisure activities. Three basic themes are stressed: first, that of using a community leisure facilitator to support people with disabilities in community…

9th Annual Science and Engineering Technology Conference

DTIC Science & Technology

2008-04-17

Disks Composite Technology Titanium Aluminides Processing Microstructure Properties Curve Generator Go-Forward: Integrated Materials & Process Models...Initiatives Current DPA/T3s: Atomic Layer Deposition Hermetic Coatings: ...domestic ALD for electronic components; transition to fabrication process ...Production windows estim • Process capability fully established >Production specifications in place >Supply chain established •All necessary property

MEETING IN TUCSON: 3MRA: A MULTI-MEDIA HUMAN AND ECOLOGICAL MODELING SYSTEM FOR SITE-SPECIFIC TO NATIONAL SCALE REGULATORY APPLICATIONS

EPA Science Inventory

3MRA provides a technology that fully integrates the full dimensionality of human and ecological exposure and risk assessment, thus allowing regulatory decisions a more complete expression of potential adverse health effects related to the disposal and reuse of contaminated waste...

Bibliographic Networks and Microcomputer Applications for Aerospace and Defense Scientific and Technical Information.

ERIC Educational Resources Information Center

Hartt, Richard W.

This report discusses the characteristics, operations, and automation requirements of technical libraries providing services to organizations involved in aerospace and defense scientific and technical work, and describes the Local Automation Model project. This on-going project is designed to demonstrate the concept of a fully integrated library…

A Design Model: The Autism Spectrum Disorder Classroom Design Kit

ERIC Educational Resources Information Center

McAllister, Keith; Maguire, Barry

2012-01-01

Architects and designers have a responsibility to provide an inclusive built environment. However, for those with a diagnosis of autism spectrum disorder (ASD), the built environment can be a frightening and confusing place, difficult to negotiate and tolerate. The challenge of integrating more fully into society is denied by an alienating built…

Integrated surface/subsurface permafrost thermal hydrology: Model formulation and proof-of-concept simulations

DOE PAGES

Painter, Scott L.; Coon, Ethan T.; Atchley, Adam L.; ...

2016-08-11

The need to understand potential climate impacts and feedbacks in Arctic regions has prompted recent interest in modeling of permafrost dynamics in a warming climate. A new fine-scale integrated surface/subsurface thermal hydrology modeling capability is described and demonstrated in proof-of-concept simulations. The new modeling capability combines a surface energy balance model with recently developed three-dimensional subsurface thermal hydrology models and new models for nonisothermal surface water flows and snow distribution in the microtopography. Surface water flows are modeled using the diffusion wave equation extended to include energy transport and phase change of ponded water. Variation of snow depth in themore » microtopography, physically the result of wind scour, is also modeled heuristically with a diffusion wave equation. The multiple surface and subsurface processes are implemented by leveraging highly parallel community software. Fully integrated thermal hydrology simulations on the tilted open book catchment, an important test case for integrated surface/subsurface flow modeling, are presented. Fine-scale 100-year projections of the integrated permafrost thermal hydrological system on an ice wedge polygon at Barrow Alaska in a warming climate are also presented. Finally, these simulations demonstrate the feasibility of microtopography-resolving, process-rich simulations as a tool to help understand possible future evolution of the carbon-rich Arctic tundra in a warming climate.« less

A fully integrated direct-conversion digital satellite tuner in 0.18 μm CMOS

NASA Astrophysics Data System (ADS)

Si, Chen; Zengwang, Yang; Mingliang, Gu

2011-04-01

A fully integrated direct-conversion digital satellite tuner for DVB-S/S2 and ABS-S applications is presented. A broadband noise-canceling Balun-LNA and passive quadrature mixers provided a high-linearity low noise RF front-end, while the synthesizer integrated the loop filter to reduce the solution cost and system debug time. Fabricated in 0.18 μm CMOS, the chip achieves a less than 7.6 dB noise figure over a 900-2150 MHz L-band, while the measured sensitivity for 4.42 MS/s QPSK-3/4 mode is -91 dBm at the PCB connector. The fully integrated integer-N synthesizer operating from 2150 to 4350 MHz achieves less than 1 °C integrated phase error. The chip consumes about 145 mA at a 3.3 V supply with internal integrated LDOs.

The development of a fully-integrated immune response model (FIRM) simulator of the immune response through integration of multiple subset models

PubMed Central

2013-01-01

Background The complexity and multiscale nature of the mammalian immune response provides an excellent test bed for the potential of mathematical modeling and simulation to facilitate mechanistic understanding. Historically, mathematical models of the immune response focused on subsets of the immune system and/or specific aspects of the response. Mathematical models have been developed for the humoral side of the immune response, or for the cellular side, or for cytokine kinetics, but rarely have they been proposed to encompass the overall system complexity. We propose here a framework for integration of subset models, based on a system biology approach. Results A dynamic simulator, the Fully-integrated Immune Response Model (FIRM), was built in a stepwise fashion by integrating published subset models and adding novel features. The approach used to build the model includes the formulation of the network of interacting species and the subsequent introduction of rate laws to describe each biological process. The resulting model represents a multi-organ structure, comprised of the target organ where the immune response takes place, circulating blood, lymphoid T, and lymphoid B tissue. The cell types accounted for include macrophages, a few T-cell lineages (cytotoxic, regulatory, helper 1, and helper 2), and B-cell activation to plasma cells. Four different cytokines were accounted for: IFN-γ, IL-4, IL-10 and IL-12. In addition, generic inflammatory signals are used to represent the kinetics of IL-1, IL-2, and TGF-β. Cell recruitment, differentiation, replication, apoptosis and migration are described as appropriate for the different cell types. The model is a hybrid structure containing information from several mammalian species. The structure of the network was built to be physiologically and biochemically consistent. Rate laws for all the cellular fate processes, growth factor production rates and half-lives, together with antibody production rates and half-lives, are provided. The results demonstrate how this framework can be used to integrate mathematical models of the immune response from several published sources and describe qualitative predictions of global immune system response arising from the integrated, hybrid model. In addition, we show how the model can be expanded to include novel biological findings. Case studies were carried out to simulate TB infection, tumor rejection, response to a blood borne pathogen and the consequences of accounting for regulatory T-cells. Conclusions The final result of this work is a postulated and increasingly comprehensive representation of the mammalian immune system, based on physiological knowledge and susceptible to further experimental testing and validation. We believe that the integrated nature of FIRM has the potential to simulate a range of responses under a variety of conditions, from modeling of immune responses after tuberculosis (TB) infection to tumor formation in tissues. FIRM also has the flexibility to be expanded to include both complex and novel immunological response features as our knowledge of the immune system advances. PMID:24074340

Integrated Distribution Management System for Alabama Principal Investigator

DOE Office of Scientific and Technical Information (OSTI.GOV)

Schatz, Joe

2013-03-31

Southern Company Services, under contract with the Department of Energy, along with Alabama Power, Alstom Grid (formerly AREVA T&D) and others moved the work product developed in the first phase of the Integrated Distribution Management System (IDMS) from “Proof of Concept” to true deployment through the activity described in this Final Report. This Project – Integrated Distribution Management Systems in Alabama – advanced earlier developed proof of concept activities into actual implementation and furthermore completed additional requirements to fully realize the benefits of an IDMS. These tasks include development and implementation of a Distribution System based Model that enables datamore » access and enterprise application integration.« less

Universality in volume-law entanglement of scrambled pure quantum states.

PubMed

Nakagawa, Yuya O; Watanabe, Masataka; Fujita, Hiroyuki; Sugiura, Sho

2018-04-24

A pure quantum state can fully describe thermal equilibrium as long as one focuses on local observables. The thermodynamic entropy can also be recovered as the entanglement entropy of small subsystems. When the size of the subsystem increases, however, quantum correlations break the correspondence and mandate a correction to this simple volume law. The elucidation of the size dependence of the entanglement entropy is thus essentially important in linking quantum physics with thermodynamics. Here we derive an analytic formula of the entanglement entropy for a class of pure states called cTPQ states representing equilibrium. We numerically find that our formula applies universally to any sufficiently scrambled pure state representing thermal equilibrium, i.e., energy eigenstates of non-integrable models and states after quantum quenches. Our formula is exploited as diagnostics for chaotic systems; it can distinguish integrable models from non-integrable models and many-body localization phases from chaotic phases.

A Test of an Integrative Model Using Social Factors and Personality Traits: Prediction on the Delinquency of South Korean Youth.

PubMed

Yun, Minwoo; Kim, Eunyoung; Park, Woong-Sub

2017-08-01

To more fully comprehend juvenile delinquency, it is necessary to take an integrative approach, with consideration of both personality traits of social risk factors. Many scholars argue the necessity and strength of integrative approach on the ground that juvenile delinquency is an outcome of interplay of individual and social factors. The present study examines the general applicability of an integrative model of personal traits and social risk factors to youth delinquency in the South Korean context. The empirical results show that the delinquency predictors in the current South Korean sample are closely aligned to Loeber and Farrington's theoretical propositions and that found in Western nations. Perhaps this is because South Korea has undergone rapid Westernization for the last decades. Because the correlates in this sample and Western theoretical propositions and studies overlap, an integrative model of personality trait and social risk factors is indeed generally applicable to South Korea. This finding also depicts the extent of Westernization in the South Korean society at least among adolescents. Limitations of the present study and directions for the future study are discussed.

ATLAS from Data Research Associates: A Fully Integrated Automation System.

ERIC Educational Resources Information Center

Mellinger, Michael J.

1987-01-01

This detailed description of a fully integrated, turnkey library system includes a complete profile of the system (functions, operational characteristics, hardware, operating system, minimum memory and pricing); history of the technologies involved; and descriptions of customer services and availability. (CLB)

A fully reconfigurable photonic integrated signal processor

NASA Astrophysics Data System (ADS)

Liu, Weilin; Li, Ming; Guzzon, Robert S.; Norberg, Erik J.; Parker, John S.; Lu, Mingzhi; Coldren, Larry A.; Yao, Jianping

2016-03-01

Photonic signal processing has been considered a solution to overcome the inherent electronic speed limitations. Over the past few years, an impressive range of photonic integrated signal processors have been proposed, but they usually offer limited reconfigurability, a feature highly needed for the implementation of large-scale general-purpose photonic signal processors. Here, we report and experimentally demonstrate a fully reconfigurable photonic integrated signal processor based on an InP-InGaAsP material system. The proposed photonic signal processor is capable of performing reconfigurable signal processing functions including temporal integration, temporal differentiation and Hilbert transformation. The reconfigurability is achieved by controlling the injection currents to the active components of the signal processor. Our demonstration suggests great potential for chip-scale fully programmable all-optical signal processing.

Planner-Based Control of Advanced Life Support Systems

NASA Technical Reports Server (NTRS)

Muscettola, Nicola; Kortenkamp, David; Fry, Chuck; Bell, Scott

2005-01-01

The paper describes an approach to the integration of qualitative and quantitative modeling techniques for advanced life support (ALS) systems. Developing reliable control strategies that scale up to fully integrated life support systems requires augmenting quantitative models and control algorithms with the abstractions provided by qualitative, symbolic models and their associated high-level control strategies. This will allow for effective management of the combinatorics due to the integration of a large number of ALS subsystems. By focusing control actions at different levels of detail and reactivity we can use faster: simpler responses at the lowest level and predictive but complex responses at the higher levels of abstraction. In particular, methods from model-based planning and scheduling can provide effective resource management over long time periods. We describe reference implementation of an advanced control system using the IDEA control architecture developed at NASA Ames Research Center. IDEA uses planning/scheduling as the sole reasoning method for predictive and reactive closed loop control. We describe preliminary experiments in planner-based control of ALS carried out on an integrated ALS simulation developed at NASA Johnson Space Center.

A transition from using multi-step procedures to a fully integrated system for performing extracorporeal photopheresis: A comparison of costs and efficiencies.

PubMed

Azar, Nabih; Leblond, Veronique; Ouzegdouh, Maya; Button, Paul

2017-12-01

The Pitié Salpêtrière Hospital Hemobiotherapy Department, Paris, France, has been providing extracorporeal photopheresis (ECP) since November 2011, and started using the Therakos ® CELLEX ® fully integrated system in 2012. This report summarizes our single-center experience of transitioning from the use of multi-step ECP procedures to the fully integrated ECP system, considering the capacity and cost implications. The total number of ECP procedures performed 2011-2015 was derived from department records. The time taken to complete a single ECP treatment using a multi-step technique and the fully integrated system at our department was assessed. Resource costs (2014€) were obtained for materials and calculated for personnel time required. Time-driven activity-based costing methods were applied to provide a cost comparison. The number of ECP treatments per year increased from 225 (2012) to 727 (2015). The single multi-step procedure took 270 min compared to 120 min for the fully integrated system. The total calculated per-session cost of performing ECP using the multi-step procedure was greater than with the CELLEX ® system (€1,429.37 and €1,264.70 per treatment, respectively). For hospitals considering a transition from multi-step procedures to fully integrated methods for ECP where cost may be a barrier, time-driven activity-based costing should be utilized to gain a more comprehensive understanding the full benefit that such a transition offers. The example from our department confirmed that there were not just cost and time savings, but that the time efficiencies gained with CELLEX ® allow for more patient treatments per year. © 2017 The Authors Journal of Clinical Apheresis Published by Wiley Periodicals, Inc.

A transition from using multi‐step procedures to a fully integrated system for performing extracorporeal photopheresis: A comparison of costs and efficiencies

PubMed Central

Leblond, Veronique; Ouzegdouh, Maya; Button, Paul

2017-01-01

Abstract Introduction The Pitié Salpêtrière Hospital Hemobiotherapy Department, Paris, France, has been providing extracorporeal photopheresis (ECP) since November 2011, and started using the Therakos® CELLEX® fully integrated system in 2012. This report summarizes our single‐center experience of transitioning from the use of multi‐step ECP procedures to the fully integrated ECP system, considering the capacity and cost implications. Materials and Methods The total number of ECP procedures performed 2011–2015 was derived from department records. The time taken to complete a single ECP treatment using a multi‐step technique and the fully integrated system at our department was assessed. Resource costs (2014€) were obtained for materials and calculated for personnel time required. Time‐driven activity‐based costing methods were applied to provide a cost comparison. Results The number of ECP treatments per year increased from 225 (2012) to 727 (2015). The single multi‐step procedure took 270 min compared to 120 min for the fully integrated system. The total calculated per‐session cost of performing ECP using the multi‐step procedure was greater than with the CELLEX® system (€1,429.37 and €1,264.70 per treatment, respectively). Conclusions For hospitals considering a transition from multi‐step procedures to fully integrated methods for ECP where cost may be a barrier, time‐driven activity‐based costing should be utilized to gain a more comprehensive understanding the full benefit that such a transition offers. The example from our department confirmed that there were not just cost and time savings, but that the time efficiencies gained with CELLEX® allow for more patient treatments per year. PMID:28419561

Fully-Integrated Simulation of Conjunctive Use from Field to Basin Scales: Development of a Surface Water Operations Module for MODFLOW-OWHM

NASA Astrophysics Data System (ADS)

Ferguson, I. M.; Boyce, S. E.; Hanson, R. T.; Llewellyn, D.

2014-12-01

It is well established that groundwater pumping affects surface-water availability by intercepting groundwater that would otherwise discharge to streams and/or by increasing seepage from surface-water channels. Conversely, surface-water management operations effect groundwater availability by altering the timing, location, and quantity of groundwater recharge and demand. Successful conjunctive use may require analysis with an integrated approach that accounts for the many interactions and feedbacks between surface-water and groundwater availability and their joint management. In order to improve simulation and analysis of conjunctive use, Bureau of Reclamation and USGS are collaborating to develop a surface-water operations module within MODFLOW One Water Hydrologic Flow Model (MF-OWHM), a new version of the USGS Modular Groundwater Flow Model (MODFLOW). Here we describe the development and application of the surface-water operations module. We provide an overview of the conceptual approach used to simulate surface-water operations—including surface-water storage, allocation, release, diversion, and delivery on monthly to seasonal time frames—in a fully-integrated manner. We then present results from a recent case study analysis of the Rio Grande Project, a large-scale irrigation project located in New Mexico and Texas, under varying surface-water operations criteria and climate conditions. Case study results demonstrate the importance of integrated hydrologic simulation of surface water and groundwater operations in analysis and management of conjunctive-use systems.

Comparing a quasi-3D to a full 3D nearshore circulation model: SHORECIRC and ROMS

USGS Publications Warehouse

Haas, Kevin A.; Warner, John C.

2009-01-01

Predictions of nearshore and surf zone processes are important for determining coastal circulation, impacts of storms, navigation, and recreational safety. Numerical modeling of these systems facilitates advancements in our understanding of coastal changes and can provide predictive capabilities for resource managers. There exists many nearshore coastal circulation models, however they are mostly limited or typically only applied as depth integrated models. SHORECIRC is an established surf zone circulation model that is quasi-3D to allow the effect of the variability in the vertical structure of the currents while maintaining the computational advantage of a 2DH model. Here we compare SHORECIRC to ROMS, a fully 3D ocean circulation model which now includes a three dimensional formulation for the wave-driven flows. We compare the models with three different test applications for: (i) spectral waves approaching a plane beach with an oblique angle of incidence; (ii) monochromatic waves driving longshore currents in a laboratory basin; and (iii) monochromatic waves on a barred beach with rip channels in a laboratory basin. Results identify that the models are very similar for the depth integrated flows and qualitatively consistent for the vertically varying components. The differences are primarily the result of the vertically varying radiation stress utilized by ROMS and the utilization of long wave theory for the radiation stress formulation in vertical varying momentum balance by SHORECIRC. The quasi-3D model is faster, however the applicability of the fully 3D model allows it to extend over a broader range of processes, temporal, and spatial scales.

Comparing a quasi-3D to a full 3D nearshore circulation model: SHORECIRC and ROMS

USGS Publications Warehouse

Haas, K.A.; Warner, J.C.

2009-01-01

Predictions of nearshore and surf zone processes are important for determining coastal circulation, impacts of storms, navigation, and recreational safety. Numerical modeling of these systems facilitates advancements in our understanding of coastal changes and can provide predictive capabilities for resource managers. There exists many nearshore coastal circulation models, however they are mostly limited or typically only applied as depth integrated models. SHORECIRC is an established surf zone circulation model that is quasi-3D to allow the effect of the variability in the vertical structure of the currents while maintaining the computational advantage of a 2DH model. Here we compare SHORECIRC to ROMS, a fully 3D ocean circulation model which now includes a three dimensional formulation for the wave-driven flows. We compare the models with three different test applications for: (i) spectral waves approaching a plane beach with an oblique angle of incidence; (ii) monochromatic waves driving longshore currents in a laboratory basin; and (iii) monochromatic waves on a barred beach with rip channels in a laboratory basin. Results identify that the models are very similar for the depth integrated flows and qualitatively consistent for the vertically varying components. The differences are primarily the result of the vertically varying radiation stress utilized by ROMS and the utilization of long wave theory for the radiation stress formulation in vertical varying momentum balance by SHORECIRC. The quasi-3D model is faster, however the applicability of the fully 3D model allows it to extend over a broader range of processes, temporal, and spatial scales. ?? 2008 Elsevier Ltd.

Automated contour detection in X-ray left ventricular angiograms using multiview active appearance models and dynamic programming.

PubMed

Oost, Elco; Koning, Gerhard; Sonka, Milan; Oemrawsingh, Pranobe V; Reiber, Johan H C; Lelieveldt, Boudewijn P F

2006-09-01

This paper describes a new approach to the automated segmentation of X-ray left ventricular (LV) angiograms, based on active appearance models (AAMs) and dynamic programming. A coupling of shape and texture information between the end-diastolic (ED) and end-systolic (ES) frame was achieved by constructing a multiview AAM. Over-constraining of the model was compensated for by employing dynamic programming, integrating both intensity and motion features in the cost function. Two applications are compared: a semi-automatic method with manual model initialization, and a fully automatic algorithm. The first proved to be highly robust and accurate, demonstrating high clinical relevance. Based on experiments involving 70 patient data sets, the algorithm's success rate was 100% for ED and 99% for ES, with average unsigned border positioning errors of 0.68 mm for ED and 1.45 mm for ES. Calculated volumes were accurate and unbiased. The fully automatic algorithm, with intrinsically less user interaction was less robust, but showed a high potential, mostly due to a controlled gradient descent in updating the model parameters. The success rate of the fully automatic method was 91% for ED and 83% for ES, with average unsigned border positioning errors of 0.79 mm for ED and 1.55 mm for ES.

Post2 End-to-End Descent and Landing Simulation for ALHAT Design Analysis Cycle 2

NASA Technical Reports Server (NTRS)

Davis, Jody L.; Striepe, Scott A.; Maddock, Robert W.; Johnson, Andrew E.; Paschall, Stephen C., II

2010-01-01

The ALHAT project is an agency-level program involving NASA centers, academia, and industry, with a primary goal to develop a safe, autonomous, precision-landing system for robotic and crew-piloted lunar and planetary descent vehicles. POST2 is used as the 6DOF descent and landing trajectory simulation for determining integrated system performance of ALHAT landing-system models and lunar environment models. This paper presents updates in the development of the ALHAT POST2 simulation, as well as preliminary system performance analysis for ALDAC-2 used for the testing and assessment of ALHAT system models. The ALDAC-2 POST2 Monte Carlo simulation results have been generated and focus on HRN model performance with the fully integrated system, as well performance improvements of AGNC and TSAR model since the previous design analysis cycle

Integrated modelling for Sustainability Appraisal of urban river corridors: going beyond compartmentalised thinking.

PubMed

Kumar, Vikas; Rouquette, J R; Lerner, David N

2013-12-15

Sustainability Appraisal (SA) is a complex task that involves integration of social, environmental and economic considerations and often requires trade-offs between multiple stakeholders that may not easily be brought to consensus. Classical SA, often compartmentalised in the rigid boundary of disciplines, can facilitate discussion, but can only partially inform decision makers as many important aspects of sustainability remain abstract and not interlinked. A fully integrated model can overcome compartmentality in the assessment process and provides opportunity for a better integrative exploratory planning process. The objective of this paper is to explore the benefit of an integrated modelling approach to SA and how a structured integrated model can be used to provide a coherent, consistent and deliberative platform to assess policy or planning proposals. The paper discusses a participative and integrative modelling approach to urban river corridor development, incorporating the principal of sustainability. The paper uses a case study site in Sheffield, UK, with three alternative development scenarios, incorporating a number of possible riverside design features. An integrated SA model is used to develop better design by optimising different design elements and delivering a more sustainable (re)-development plan. We conclude that participatory integrated modelling has strong potential for supporting the SA processes. A high degree of integration provides the opportunity for more inclusive and informed decision-making regarding issues of urban development. It also provides the opportunity to reflect on their long-term dynamics, and to gain insights on the interrelationships underlying persistent sustainability problems. Thus the ability to address economic, social and environmental interdependencies within policies, plans, and legislations is enhanced. Copyright © 2013 Elsevier Ltd. All rights reserved.

Probabilistic models of eukaryotic evolution: time for integration

PubMed Central

Lartillot, Nicolas

2015-01-01

In spite of substantial work and recent progress, a global and fully resolved picture of the macroevolutionary history of eukaryotes is still under construction. This concerns not only the phylogenetic relations among major groups, but also the general characteristics of the underlying macroevolutionary processes, including the patterns of gene family evolution associated with endosymbioses, as well as their impact on the sequence evolutionary process. All these questions raise formidable methodological challenges, calling for a more powerful statistical paradigm. In this direction, model-based probabilistic approaches have played an increasingly important role. In particular, improved models of sequence evolution accounting for heterogeneities across sites and across lineages have led to significant, although insufficient, improvement in phylogenetic accuracy. More recently, one main trend has been to move away from simple parametric models and stepwise approaches, towards integrative models explicitly considering the intricate interplay between multiple levels of macroevolutionary processes. Such integrative models are in their infancy, and their application to the phylogeny of eukaryotes still requires substantial improvement of the underlying models, as well as additional computational developments. PMID:26323768

Developing an integrated 3D-hydrodynamic and emerging contaminant model for assessing water quality in a Yangtze Estuary Reservoir.

PubMed

Xu, Cong; Zhang, Jingjie; Bi, Xiaowei; Xu, Zheng; He, Yiliang; Gin, Karina Yew-Hoong

2017-12-01

An integrated 3D-hydrodynamic and emerging contaminant model was developed for better understanding of the fate and transport of emerging contaminants in Qingcaosha Reservoir. The reservoir, which supplies drinking water for nearly half of Shanghai's population, is located in Yangtze Delta. The integrated model was built by Delft3D suite, a fully integrated multidimensional modeling software. Atrazine and Bisphenol A (BPA) were selected as two representative emerging contaminants for the study in this reservoir. The hydrodynamic model was calibrated and validated against observations from 2011 to 2015 while the integrated model was calibrated against observations from 2014 to 2015 and then applied to explore the potential risk of high atrazine concentrations in the reservoir driven by agriculture activities. Our results show that the model is capable of describing the spatial and temporal patterns of water temperature, salinity and the dynamic distributions of two representative emerging contaminants (i.e. atrazine and BPA) in the reservoir. The physical and biodegradation processes in this study were found to play a crucial role in determining the fate and transport of atrazine and BPA in the reservoir. The model also provides an insight into the potential risk of emerging contaminants and possible mitigation thresholds. The integrated approach can be a very useful tool to support policy-makers in the future management of Qingcaosha Reservoir. Copyright © 2017 Elsevier Ltd. All rights reserved.

Earth-moon system: Dynamics and parameter estimation

NASA Technical Reports Server (NTRS)

Breedlove, W. J., Jr.

1975-01-01

A theoretical development of the equations of motion governing the earth-moon system is presented. The earth and moon were treated as finite rigid bodies and a mutual potential was utilized. The sun and remaining planets were treated as particles. Relativistic, non-rigid, and dissipative effects were not included. The translational and rotational motion of the earth and moon were derived in a fully coupled set of equations. Euler parameters were used to model the rotational motions. The mathematical model is intended for use with data analysis software to estimate physical parameters of the earth-moon system using primarily LURE type data. Two program listings are included. Program ANEAMO computes the translational/rotational motion of the earth and moon from analytical solutions. Program RIGEM numerically integrates the fully coupled motions as described above.

Integrated modeling of high βN steady state scenario on DIII-D

DOE PAGES

Park, Jin Myung; Ferron, J. R.; Holcomb, Christopher T.; ...

2018-01-10

Theory-based integrated modeling validated against DIII-D experiments predicts that fully non-inductive DIII-D operation with β N > 4.5 is possible with certain upgrades. IPS-FASTRAN is a new iterative numerical procedure that integrates models of core transport, edge pedestal, equilibrium, stability, heating, and current drive self-consistently to find steady-state ( d/dt = 0) solutions and reproduces most features of DIII-D high β N discharges with a stationary current profile. Projecting forward to scenarios possible on DIII-D with future upgrades, the high q min > 2 scenario achieves stable operation at β N as high as 5 by using a very broadmore » current density profile to improve the ideal-wall stabilization of low- n instabilities along with confinement enhancement from low magnetic shear. This modeling guides the necessary upgrades of the heating and current drive system to realize reactor-relevant high β N steady-state scenarios on DIII-D by simultaneous optimization of the current and pressure profiles.« less

An Implicit Algorithm for the Numerical Simulation of Shape-Memory Alloys

DOE Office of Scientific and Technical Information (OSTI.GOV)

Becker, R; Stolken, J; Jannetti, C

Shape-memory alloys (SMA) have the potential to be used in a variety of interesting applications due to their unique properties of pseudoelasticity and the shape-memory effect. However, in order to design SMA devices efficiently, a physics-based constitutive model is required to accurately simulate the behavior of shape-memory alloys. The scope of this work is to extend the numerical capabilities of the SMA constitutive model developed by Jannetti et. al. (2003), to handle large-scale polycrystalline simulations. The constitutive model is implemented within the finite-element software ABAQUS/Standard using a user defined material subroutine, or UMAT. To improve the efficiency of the numericalmore » simulations, so that polycrystalline specimens of shape-memory alloys can be modeled, a fully implicit algorithm has been implemented to integrate the constitutive equations. Using an implicit integration scheme increases the efficiency of the UMAT over the previously implemented explicit integration method by a factor of more than 100 for single crystal simulations.« less

Integrated modeling of high βN steady state scenario on DIII-D

DOE Office of Scientific and Technical Information (OSTI.GOV)

Park, Jin Myung; Ferron, J. R.; Holcomb, Christopher T.

Theory-based integrated modeling validated against DIII-D experiments predicts that fully non-inductive DIII-D operation with β N > 4.5 is possible with certain upgrades. IPS-FASTRAN is a new iterative numerical procedure that integrates models of core transport, edge pedestal, equilibrium, stability, heating, and current drive self-consistently to find steady-state ( d/dt = 0) solutions and reproduces most features of DIII-D high β N discharges with a stationary current profile. Projecting forward to scenarios possible on DIII-D with future upgrades, the high q min > 2 scenario achieves stable operation at β N as high as 5 by using a very broadmore » current density profile to improve the ideal-wall stabilization of low- n instabilities along with confinement enhancement from low magnetic shear. This modeling guides the necessary upgrades of the heating and current drive system to realize reactor-relevant high β N steady-state scenarios on DIII-D by simultaneous optimization of the current and pressure profiles.« less

Integrated modeling of high βN steady state scenario on DIII-D

NASA Astrophysics Data System (ADS)

Park, J. M.; Ferron, J. R.; Holcomb, C. T.; Buttery, R. J.; Solomon, W. M.; Batchelor, D. B.; Elwasif, W.; Green, D. L.; Kim, K.; Meneghini, O.; Murakami, M.; Snyder, P. B.

2018-01-01

Theory-based integrated modeling validated against DIII-D experiments predicts that fully non-inductive DIII-D operation with βN > 4.5 is possible with certain upgrades. IPS-FASTRAN is a new iterative numerical procedure that integrates models of core transport, edge pedestal, equilibrium, stability, heating, and current drive self-consistently to find steady-state (d/dt = 0) solutions and reproduces most features of DIII-D high βN discharges with a stationary current profile. Projecting forward to scenarios possible on DIII-D with future upgrades, the high qmin > 2 scenario achieves stable operation at βN as high as 5 by using a very broad current density profile to improve the ideal-wall stabilization of low-n instabilities along with confinement enhancement from low magnetic shear. This modeling guides the necessary upgrades of the heating and current drive system to realize reactor-relevant high βN steady-state scenarios on DIII-D by simultaneous optimization of the current and pressure profiles.

Solution of the Wang Chang-Uhlenbeck equation for molecular hydrogen

NASA Astrophysics Data System (ADS)

Anikin, Yu. A.

2017-06-01

Molecular hydrogen is modeled by numerically solving the Wang Chang-Uhlenbeck equation. The differential scattering cross sections of molecules are calculated using the quantum mechanical scattering theory of rigid rotors. The collision integral is computed by applying a fully conservative projection method. Numerical results for relaxation, heat conduction, and a one-dimensional shock wave are presented.

Principal Leadership and School Culture with a School-Wide Implementation of Professional Crisis Management: A Redemptive v. Punitive Model

ERIC Educational Resources Information Center

Adams, Mark Thomas

2013-01-01

This qualitative study investigated the nature of the relationship between principal leadership and school culture within a school-wide implementation of Professional Crisis Management (PCM). PCM is a comprehensive and fully integrated system designed to manage crisis situations effectively, safely, and with dignity. While designed primarily to…

Different modelling approaches to evaluate nitrogen transport and turnover at the watershed scale

NASA Astrophysics Data System (ADS)

Epelde, Ane Miren; Antiguedad, Iñaki; Brito, David; Jauch, Eduardo; Neves, Ramiro; Garneau, Cyril; Sauvage, Sabine; Sánchez-Pérez, José Miguel

2016-08-01

This study presents the simulation of hydrological processes and nutrient transport and turnover processes using two integrated numerical models: Soil and Water Assessment Tool (SWAT) (Arnold et al., 1998), an empirical and semi-distributed numerical model; and Modelo Hidrodinâmico (MOHID) (Neves, 1985), a physics-based and fully distributed numerical model. This work shows that both models reproduce satisfactorily water and nitrate exportation at the watershed scale at annual and daily basis, MOHID providing slightly better results. At the watershed scale, both SWAT and MOHID simulated similarly and satisfactorily the denitrification amount. However, as MOHID numerical model was the only one able to reproduce adequately the spatial variation of the soil hydrological conditions and water table level fluctuation, it proved to be the only model able of reproducing the spatial variation of the nutrient cycling processes that are dependent to the soil hydrological conditions such as the denitrification process. This evidences the strength of the fully distributed and physics-based models to simulate the spatial variability of nutrient cycling processes that are dependent to the hydrological conditions of the soils.

Building sector feedbacks lead to increased energy demands

NASA Astrophysics Data System (ADS)

Hartin, C.; Link, R. P.; Patel, P.; Horowitz, R.; Clarke, L.; Mundra, A.

2017-12-01

Typically in human-earth system modeling studies, feedbacks between the earth and human systems are analyzed by passing information between independent models, leading to data errors and poor reproducibility. In this study we explore the two-way feedbacks between the human and earth systems in the building sector of GCAM, an integrated assessment model and, its fully-integrated climate component, Hector. While there is a general agreement in the literature that increasing temperatures will increase cooling energy demands and decrease heating energy demands, there has been no fully-coupled analysis of this dynamic that would, for example, account for the feedbacks on hydrofluorocarbons from increased cooling demands. Using a statistical relationship between global mean temperature change and heating and cooling degree days, we find that the feedbacks on hydrofluorocarbons lead to an increase in global mean temperature of between 0.16 to 0.27 °C in 2100. Demands for electricity increase by about 10% in Africa, while demands decrease in Canada by about 3.0% when taking into account these feedbacks. While the feedbacks between building energy demand and global mean temperature are modest by themselves, this study prompts future research on coupled human-earth system feedbacks, in particular in regards to land, water, and other energy infrastructure.

A Fully Associative, Non-Linear Kinematic, Unified Viscoplastic Model for Titanium Based Matrices

NASA Technical Reports Server (NTRS)

Arnold, S. M.; Saleeb, A. F.; Castelli, M. G.

1994-01-01

Specific forms for both the Gibb's and complementary dissipation potentials are chosen such that a complete (i.e., fully associative) potential based multiaxial unified viscoplastic model is obtained. This model possesses one tensorial internal state variable that is associated with dislocation substructure, with an evolutionary law that has nonlinear kinematic hardening and both thermal and strain induced recovery mechanisms. A unique aspect of the present model is the inclusion of non-linear hardening through the use of a compliance operator, derived from the Gibb's potential, in the evolution law for the back stress. This non-linear tensorial operator is significant in that it allows both the flow and evolutionary laws to be fully associative (and therefore easily integrated) and greatly influences the multiaxial response under non-proportional loading paths. In addition to this nonlinear compliance operator, a new consistent, potential preserving, internal strain unloading criterion has been introduced to prevent abnormalities in the predicted stress-strain curves, which are present with nonlinear hardening formulations, during unloading and reversed loading of the external variables. Specification of an experimental program for the complete determination of the material functions and parameters for characterizing a metallic matrix, e.g., TIMETAL 21S, is given. The experiments utilized are tensile, creep, and step creep tests. Finally, a comparison of this model and a commonly used Bodner-Partom model is made on the basis of predictive accuracy and numerical efficiency.

An Anatomically Constrained Model for Path Integration in the Bee Brain.

PubMed

Stone, Thomas; Webb, Barbara; Adden, Andrea; Weddig, Nicolai Ben; Honkanen, Anna; Templin, Rachel; Wcislo, William; Scimeca, Luca; Warrant, Eric; Heinze, Stanley

2017-10-23

Path integration is a widespread navigational strategy in which directional changes and distance covered are continuously integrated on an outward journey, enabling a straight-line return to home. Bees use vision for this task-a celestial-cue-based visual compass and an optic-flow-based visual odometer-but the underlying neural integration mechanisms are unknown. Using intracellular electrophysiology, we show that polarized-light-based compass neurons and optic-flow-based speed-encoding neurons converge in the central complex of the bee brain, and through block-face electron microscopy, we identify potential integrator cells. Based on plausible output targets for these cells, we propose a complete circuit for path integration and steering in the central complex, with anatomically identified neurons suggested for each processing step. The resulting model circuit is thus fully constrained biologically and provides a functional interpretation for many previously unexplained architectural features of the central complex. Moreover, we show that the receptive fields of the newly discovered speed neurons can support path integration for the holonomic motion (i.e., a ground velocity that is not precisely aligned with body orientation) typical of bee flight, a feature not captured in any previously proposed model of path integration. In a broader context, the model circuit presented provides a general mechanism for producing steering signals by comparing current and desired headings-suggesting a more basic function for central complex connectivity, from which path integration may have evolved. Copyright © 2017 Elsevier Ltd. All rights reserved.

An integrated approach to reservoir modeling

DOE Office of Scientific and Technical Information (OSTI.GOV)

Donaldson, K.

1993-08-01

The purpose of this research is to evaluate the usefulness of the following procedural and analytical methods in investigating the heterogeneity of the oil reserve for the Mississipian Big Injun Sandstone of the Granny Creek field, Clay and Roane counties, West Virginia: (1) relational database, (2) two-dimensional cross sections, (3) true three-dimensional modeling, (4) geohistory analysis, (5) a rule-based expert system, and (6) geographical information systems. The large data set could not be effectively integrated and interpreted without this approach. A relational database was designed to fully integrate three- and four-dimensional data. The database provides an effective means for maintainingmore » and manipulating the data. A two-dimensional cross section program was designed to correlate stratigraphy, depositional environments, porosity, permeability, and petrographic data. This flexible design allows for additional four-dimensional data. Dynamic Graphics[sup [trademark

A Fully Nonlinear, Dynamically Consistent Numerical Model for Solid-Body Ship Motion. I. Ship Motion with Fixed Heading

NASA Technical Reports Server (NTRS)

Lin, Ray-Quing; Kuang, Weijia

2011-01-01

In this paper, we describe the details of our numerical model for simulating ship solidbody motion in a given environment. In this model, the fully nonlinear dynamical equations governing the time-varying solid-body ship motion under the forces arising from ship wave interactions are solved with given initial conditions. The net force and moment (torque) on the ship body are directly calculated via integration of the hydrodynamic pressure over the wetted surface and the buoyancy effect from the underwater volume of the actual ship hull with a hybrid finite-difference/finite-element method. Neither empirical nor free parametrization is introduced in this model, i.e. no a priori experimental data are needed for modelling. This model is benchmarked with many experiments of various ship hulls for heave, roll and pitch motion. In addition to the benchmark cases, numerical experiments are also carried out for strongly nonlinear ship motion with a fixed heading. These new cases demonstrate clearly the importance of nonlinearities in ship motion modelling.

An integrated radar model solution for mission level performance and cost trades

NASA Astrophysics Data System (ADS)

Hodge, John; Duncan, Kerron; Zimmerman, Madeline; Drupp, Rob; Manno, Mike; Barrett, Donald; Smith, Amelia

2017-05-01

A fully integrated Mission-Level Radar model is in development as part of a multi-year effort under the Northrop Grumman Mission Systems (NGMS) sector's Model Based Engineering (MBE) initiative to digitally interconnect and unify previously separate performance and cost models. In 2016, an NGMS internal research and development (IR and D) funded multidisciplinary team integrated radio frequency (RF), power, control, size, weight, thermal, and cost models together using a commercial-off-the-shelf software, ModelCenter, for an Active Electronically Scanned Array (AESA) radar system. Each represented model was digitally connected with standard interfaces and unified to allow end-to-end mission system optimization and trade studies. The radar model was then linked to the Air Force's own mission modeling framework (AFSIM). The team first had to identify the necessary models, and with the aid of subject matter experts (SMEs) understand and document the inputs, outputs, and behaviors of the component models. This agile development process and collaboration enabled rapid integration of disparate models and the validation of their combined system performance. This MBE framework will allow NGMS to design systems more efficiently and affordably, optimize architectures, and provide increased value to the customer. The model integrates detailed component models that validate cost and performance at the physics level with high-level models that provide visualization of a platform mission. This connectivity of component to mission models allows hardware and software design solutions to be better optimized to meet mission needs, creating cost-optimal solutions for the customer, while reducing design cycle time through risk mitigation and early validation of design decisions.

Cognitive theory in anorexia nervosa and bulimia nervosa: progress, development and future directions.

PubMed

Cooper, Myra J

2005-06-01

Important developments have taken place in cognitive theory of eating disorders (EDs) (and also in other disorders) since the review paper published by M.J. Cooper in 1997. The relevant empirical database has also expanded. Nevertheless, cognitive therapy for anorexia nervosa and bulimia nervosa, although helpful to many patients, leaves much to be desired. The current paper reviews the relevant empirical evidence collected, and the theoretical revisions that have been made to cognitive models of eating disorders, since 1997. The status and limitations of these developments are considered, including whether or not they meet the criteria for "good" theory. New theoretical developments relevant to cognitive explanations of eating disorders (second generation theories) are then presented, and the preliminary evidence that supports these is briefly reviewed. The lack of integration between cognitive theories of EDs and risk (vulnerability) factor research is noted, and a potential model that unites the two is noted. The implications of the review for future research and the development of cognitive theory in eating disorders are then discussed. These include the need for study of cognitive constructs not yet fully integrated (or indeed not yet applied clinically) into current theories and the need for cognitive theories of eating disorders to continue to evolve (as they have indeed done since 1997) in order to fully integrate such constructs. Treatment studies incorporating these new developments also urgently need to be undertaken.

Microfluidic vascularized bone tissue model with hydroxyapatite-incorporated extracellular matrix.

PubMed

Jusoh, Norhana; Oh, Soojung; Kim, Sudong; Kim, Jangho; Jeon, Noo Li

2015-10-21

Current in vitro systems mimicking bone tissues fail to fully integrate the three-dimensional (3D) microvasculature and bone tissue microenvironments, decreasing their similarity to in vivo conditions. Here, we propose 3D microvascular networks in a hydroxyapatite (HA)-incorporated extracellular matrix (ECM) for designing and manipulating a vascularized bone tissue model in a microfluidic device. Incorporation of HA of various concentrations resulted in ECM with varying mechanical properties. Sprouting angiogenesis was affected by mechanically modulated HA-extracellular matrix interactions, generating a model of vascularized bone microenvironment. Using this platform, we observed that hydroxyapatite enhanced angiogenic properties such as sprout length, sprouting speed, sprout number, and lumen diameter. This new platform integrates fibrin ECM with the synthetic bone mineral HA to provide in vivo-like microenvironments for bone vessel sprouting.

Multiscale mechanobiology: computational models for integrating molecules to multicellular systems

PubMed Central

Mak, Michael; Kim, Taeyoon

2015-01-01

Mechanical signals exist throughout the biological landscape. Across all scales, these signals, in the form of force, stiffness, and deformations, are generated and processed, resulting in an active mechanobiological circuit that controls many fundamental aspects of life, from protein unfolding and cytoskeletal remodeling to collective cell motions. The multiple scales and complex feedback involved present a challenge for fully understanding the nature of this circuit, particularly in development and disease in which it has been implicated. Computational models that accurately predict and are based on experimental data enable a means to integrate basic principles and explore fine details of mechanosensing and mechanotransduction in and across all levels of biological systems. Here we review recent advances in these models along with supporting and emerging experimental findings. PMID:26019013

Fully implicit adaptive mesh refinement MHD algorithm

NASA Astrophysics Data System (ADS)

Philip, Bobby

2005-10-01

In the macroscopic simulation of plasmas, the numerical modeler is faced with the challenge of dealing with multiple time and length scales. The former results in stiffness due to the presence of very fast waves. The latter requires one to resolve the localized features that the system develops. Traditional approaches based on explicit time integration techniques and fixed meshes are not suitable for this challenge, as such approaches prevent the modeler from using realistic plasma parameters to keep the computation feasible. We propose here a novel approach, based on implicit methods and structured adaptive mesh refinement (SAMR). Our emphasis is on both accuracy and scalability with the number of degrees of freedom. To our knowledge, a scalable, fully implicit AMR algorithm has not been accomplished before for MHD. As a proof-of-principle, we focus on the reduced resistive MHD model as a basic MHD model paradigm, which is truly multiscale. The approach taken here is to adapt mature physics-based technologyootnotetextL. Chac'on et al., J. Comput. Phys. 178 (1), 15- 36 (2002) to AMR grids, and employ AMR-aware multilevel techniques (such as fast adaptive composite --FAC-- algorithms) for scalability. We will demonstrate that the concept is indeed feasible, featuring optimal scalability under grid refinement. Results of fully-implicit, dynamically-adaptive AMR simulations will be presented on a variety of problems.

Modelling of double air-bridged structured inductor implemented by a GaAs integrated passive device manufacturing process

NASA Astrophysics Data System (ADS)

Li, Yang; Yao, Zhao; Zhang, Chun-Wei; Fu, Xiao-Qian; Li, Zhi-Ming; Li, Nian-Qiang; Wang, Cong

2017-05-01

In order to provide excellent performance and show the development of a complicated structure in a module and system, this paper presents a double air-bridge-structured symmetrical differential inductor based on integrated passive device technology. Corresponding to the proposed complicated structure, a new manufacturing process fabricated on a high-resistivity GaAs substrate is described in detail. Frequency-independent physical models are presented with lump elements and the results of skin effect-based measurements. Finally, some key features of the inductor are compared; good agreement between the measurements and modeled circuit fully verifies the validity of the proposed modeling approach. Meanwhile, we also present a comparison of different coil turns for inductor performance. The proposed work can provide a good solution for the design, fabrication, modeling, and practical application of radio-frequency modules and systems.

Three-Dimensional Simulations of Electron Beams Focused by Periodic Permanent Magnets

NASA Technical Reports Server (NTRS)

Kory, Carol L.

1999-01-01

A fully three-dimensional (3D) model of an electron beam focused by a periodic permanent magnet (PPM) stack has been developed. First, the simulation code MAFIA was used to model a PPM stack using the magnetostatic solver. The exact geometry of the magnetic focusing structure was modeled; thus, no approximations were made regarding the off-axis fields. The fields from the static solver were loaded into the 3D particle-in-cell (PIC) solver of MAFIA where fully 3D behavior of the beam was simulated in the magnetic focusing field. The PIC solver computes the time-integration of electromagnetic fields simultaneously with the time integration of the equations of motion of charged particles that move under the influence of those fields. Fields caused by those moving charges are also taken into account; thus, effects like space charge and magnetic forces between particles are fully simulated. The electron beam is simulated by a number of macro-particles. These macro-particles represent a given charge Q amounting to that of several million electrons in order to conserve computational time and memory. Particle motion is unrestricted, so particle trajectories can cross paths and move in three dimensions under the influence of 3D electric and magnetic fields. Correspondingly, there is no limit on the initial current density distribution of the electron beam, nor its density distribution at any time during the simulation. Simulation results including beam current density, percent ripple and percent transmission will be presented, and the effects current, magnetic focusing strength and thermal velocities have on beam behavior will be demonstrated using 3D movies showing the evolution of beam characteristics in time and space. Unlike typical beam optics models, this 3D model allows simulation of asymmetric designs such as non- circularly symmetric electrostatic or magnetic focusing as well as the inclusion of input/output couplers.

Noise Figure Optimization of Fully Integrated Inductively Degenerated Silicon Germanium HBT LNAs

NASA Astrophysics Data System (ADS)

Ibrahim, Mohamed Farhat

Silicon germanium (SiGe) heterojunction bipolar transistors (HBTs) have the properties of producing very low noise and high gain over a wide bandwidth. Because of these properties, SiGe HBTs have continually improved and now compete with InP and GaAs HEMTs for low-noise amplification. This thesis investigates the theoretical characterizations and optimizations of SiGe HBT low noise amplifiers (LNAs) for low-noise low-power applications, using SiGe BiCMOS (bipolar complementary metal-oxide-semiconductor) technology. The theoretical characterization of SiGe HBT transistors is investigated by a comprehensive study of the DC and small-signal transistor modeling. Based on a selected small-signal model, a noise model for the SiGe HBT transistor is produced. This noise model is used to build a cascode inductively degenerated SiGe HBT LNA circuit. The noise figure (NF) equation for this LNA is derived. This NF equation shows better than 94.4% agreement with the simulation results. With the small-signal model verification, a new analytical method for optimizing the noise figure of the SiGe HBT LNA circuits is presented. The novelty feature of this optimization is the inclusion of the noise contributions of the base inductor parasitic resistance, the emitter inductor parasitic resistance and the bond-wire inductor parasitic resistances. The optimization is performed by reducing the number of design variables as possible. This improved theoretical optimization results in LNA designs that achieve better noise figure performance compared to previously published results in bipolar and BiCMOS technologies. Different design constraints are discussed for the LNA optimization techniques. Three different LNAs are designed. The three designs are fully integrated and fabricated in a single chip to achieve a fully monolithic realization. The LNA designs are experimentally verified. The low noise design produced a NF of 1.5dB, S21 of 15dB, and power consumption of 15mW. The three LNA designs occupied 1.4mum 2 in 130 nm BiCMOS technology.

A variable resolution nonhydrostatic global atmospheric semi-implicit semi-Lagrangian model

NASA Astrophysics Data System (ADS)

Pouliot, George Antoine

2000-10-01

The objective of this project is to develop a variable-resolution finite difference adiabatic global nonhydrostatic semi-implicit semi-Lagrangian (SISL) model based on the fully compressible nonhydrostatic atmospheric equations. To achieve this goal, a three-dimensional variable resolution dynamical core was developed and tested. The main characteristics of the dynamical core can be summarized as follows: Spherical coordinates were used in a global domain. A hydrostatic/nonhydrostatic switch was incorporated into the dynamical equations to use the fully compressible atmospheric equations. A generalized horizontal variable resolution grid was developed and incorporated into the model. For a variable resolution grid, in contrast to a uniform resolution grid, the order of accuracy of finite difference approximations is formally lost but remains close to the order of accuracy associated with the uniform resolution grid provided the grid stretching is not too significant. The SISL numerical scheme was implemented for the fully compressible set of equations. In addition, the generalized minimum residual (GMRES) method with restart and preconditioner was used to solve the three-dimensional elliptic equation derived from the discretized system of equations. The three-dimensional momentum equation was integrated in vector-form to incorporate the metric terms in the calculations of the trajectories. Using global re-analysis data for a specific test case, the model was compared to similar SISL models previously developed. Reasonable agreement between the model and the other independently developed models was obtained. The Held-Suarez test for dynamical cores was used for a long integration and the model was successfully integrated for up to 1200 days. Idealized topography was used to test the variable resolution component of the model. Nonhydrostatic effects were simulated at grid spacings of 400 meters with idealized topography and uniform flow. Using a high-resolution topographic data set and the variable resolution grid, sets of experiments with increasing resolution were performed over specific regions of interest. Using realistic initial conditions derived from re-analysis fields, nonhydrostatic effects were significant for grid spacings on the order of 0.1 degrees with orographic forcing. If the model code was adapted for use in a message passing interface (MPI) on a parallel supercomputer today, it was estimated that a global grid spacing of 0.1 degrees would be achievable for a global model. In this case, nonhydrostatic effects would be significant for most areas. A variable resolution grid in a global model provides a unified and flexible approach to many climate and numerical weather prediction problems. The ability to configure the model from very fine to very coarse resolutions allows for the simulation of atmospheric phenomena at different scales using the same code. We have developed a dynamical core illustrating the feasibility of using a variable resolution in a global model.

Integrated Canada-U.S. Power Sector Modeling with the Regional Energy Deployment System (ReEDS)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Martinez, A.; Eurek, K.; Mai, T.

2013-02-01

The electric power system in North America is linked between the United States and Canada. Canada has historically been a net exporter of electricity to the United States. The extent to which this remains true will depend on the future evolution of power markets, technology deployment, and policies. To evaluate these and related questions, we modify the Regional Energy Deployment System (ReEDS) model to include an explicit representation of the grid-connected power system in Canada to the continental United States. ReEDS is unique among long-term capacity expansion models for its high spatial resolution and statistical treatment of the impact ofmore » variable renewable generation on capacity planning and dispatch. These unique traits are extended to new Canadian regions. We present example scenario results using the fully integrated Canada-U.S. version of ReEDS to demonstrate model capabilities. The newly developed, integrated Canada-U.S. ReEDS model can be used to analyze the dynamics of electricity transfers and other grid services between the two countries under different scenarios.« less

Integration of strained and relaxed silicon thin films on silicon wafers via engineered oxide heterostructures: Experiment and theory

NASA Astrophysics Data System (ADS)

Seifarth, O.; Dietrich, B.; Zaumseil, P.; Giussani, A.; Storck, P.; Schroeder, T.

2010-10-01

Strained and relaxed single crystalline Si on insulator systems is an important materials science approach for future Si-based nanoelectronics. Layer transfer techniques are the dominating global integration approach over the whole wafer system but are difficult to scale down for local integration purposes limited to the area of the future device. In this respect, the heteroepitaxy approach by two simple subsequent epitaxial deposition steps of the oxide and the Si thin film is a promising way. We introduce tailored (Pr2O3)1-x(Y2O3)x oxide heterostructures on Si(111) as flexible heteroepitaxy concept for the integration of either strained or fully relaxed single crystalline Si thin films. Two different buffer concepts are explored by a combined experimental and theoretical study. First, the growth of fully relaxed single crystalline Si films is achieved by the growth of mixed PrYO3 insulators on Si(111) whose lattice constant is matched to Si. Second, isomorphic oxide-on-oxide epitaxy is exploited to grow strained Si films on lattice mismatched Y2O3/Pr2O3/Si(111) support systems. A thickness dependent multilayer model, based on Matthew's approach for strain relaxation by misfit dislocations, is presented to describe the experimental data.

The Impact of an Alternative Professional Development Model on Teacher Practices in Formative Assessment and Student Learning

ERIC Educational Resources Information Center

Robinson, Jack; Myran, Steve; Strauss, Richard; Reed, William

2014-01-01

Among contemporary means of enhancing student learning, formative assessment is perhaps one of the most important and effective. While formative assessment ideas and practices have been shown to have a proven record enhancing student learning, these practices are slow to be fully integrated into teachers' day-to-day classroom practices. This study…

Potential Teaching Model for Applying Novel Approaches of Renewed Estonian National Curriculum into Visual Art Classes in Primary School

ERIC Educational Resources Information Center

Vahter, Edna

2015-01-01

In 2010, the renewed national curriculum was legislated in Estonia. Major changes include a new list of cross-curricular topics, increased importance of integration and specification of the components of the art learning process. In this situation, the question arises--how to fully implement the challenges of the renewed curriculum in primary…

Parallel numerical modeling of hybrid-dimensional compositional non-isothermal Darcy flows in fractured porous media

NASA Astrophysics Data System (ADS)

Xing, F.; Masson, R.; Lopez, S.

2017-09-01

This paper introduces a new discrete fracture model accounting for non-isothermal compositional multiphase Darcy flows and complex networks of fractures with intersecting, immersed and non-immersed fractures. The so called hybrid-dimensional model using a 2D model in the fractures coupled with a 3D model in the matrix is first derived rigorously starting from the equi-dimensional matrix fracture model. Then, it is discretized using a fully implicit time integration combined with the Vertex Approximate Gradient (VAG) finite volume scheme which is adapted to polyhedral meshes and anisotropic heterogeneous media. The fully coupled systems are assembled and solved in parallel using the Single Program Multiple Data (SPMD) paradigm with one layer of ghost cells. This strategy allows for a local assembly of the discrete systems. An efficient preconditioner is implemented to solve the linear systems at each time step and each Newton type iteration of the simulation. The numerical efficiency of our approach is assessed on different meshes, fracture networks, and physical settings in terms of parallel scalability, nonlinear convergence and linear convergence.

Selected Tether Applications Cost Model

NASA Technical Reports Server (NTRS)

Keeley, Michael G.

1988-01-01

Diverse cost-estimating techniques and data combined into single program. Selected Tether Applications Cost Model (STACOM 1.0) is interactive accounting software tool providing means for combining several independent cost-estimating programs into fully-integrated mathematical model capable of assessing costs, analyzing benefits, providing file-handling utilities, and putting out information in text and graphical forms to screen, printer, or plotter. Program based on Lotus 1-2-3, version 2.0. Developed to provide clear, concise traceability and visibility into methodology and rationale for estimating costs and benefits of operations of Space Station tether deployer system.

Direct use of linear time-domain aerodynamics in aeroservoelastic analysis: Aerodynamic model

NASA Technical Reports Server (NTRS)

Woods, J. A.; Gilbert, Michael G.

1990-01-01

The work presented here is the first part of a continuing effort to expand existing capabilities in aeroelasticity by developing the methodology which is necessary to utilize unsteady time-domain aerodynamics directly in aeroservoelastic design and analysis. The ultimate objective is to define a fully integrated state-space model of an aeroelastic vehicle's aerodynamics, structure and controls which may be used to efficiently determine the vehicle's aeroservoelastic stability. Here, the current status of developing a state-space model for linear or near-linear time-domain indicial aerodynamic forces is presented.

MODFLOW-OWHM v2: The next generation of fully integrated hydrologic simulation software

NASA Astrophysics Data System (ADS)

Boyce, S. E.; Hanson, R. T.; Ferguson, I. M.; Reimann, T.; Henson, W.; Mehl, S.; Leake, S.; Maddock, T.

2016-12-01

The One-Water Hydrologic Flow Model (One-Water) is a MODFLOW-based integrated hydrologic flow model designed for the analysis of a broad range of conjunctive-use and climate-related issues. One-Water fully links the movement and use of groundwater, surface water, and imported water for consumption by agriculture and natural vegetation on the landscape, and for potable and other uses within a supply-and-demand framework. One-Water includes linkages for deformation-, flow-, and head-dependent flows; additional observation and parameter options for higher-order calibrations; and redesigned code for facilitation of self-updating models and faster simulation run times. The next version of One-Water, currently under development, will include a new surface-water operations module that simulates dynamic reservoir operations, a new sustainability analysis package that facilitates the estimation and simulation of reduced storage depletion and captured discharge, a conduit-flow process for karst aquifers and leaky pipe networks, a soil zone process that adds an enhanced infiltration process, interflow, deep percolation and soil moisture, and a new subsidence and aquifer compaction package. It will also include enhancements to local grid refinement, and additional features to facilitate easier model updates, faster execution, better error messages, and more integration/cross communication between the traditional MODFLOW packages. By retaining and tracking the water within the hydrosphere, One-Water accounts for "all of the water everywhere and all of the time." This philosophy provides more confidence in the water accounting by the scientific community and provides the public a foundation needed to address wider classes of problems. Ultimately, more complex questions are being asked about water resources, so they require a more complete answer about conjunctive-use and climate-related issues.

The One-Water Hydrologic Flow Model - The next generation in fully integrated hydrologic simulation software

NASA Astrophysics Data System (ADS)

Boyce, S. E.; Hanson, R. T.

2015-12-01

The One-Water Hydrologic Flow Model (MF-OWHM) is a MODFLOW-based integrated hydrologic flow model that is the most complete version, to date, of the MODFLOW family of hydrologic simulators needed for the analysis of a broad range of conjunctive-use issues. MF-OWHM fully links the movement and use of groundwater, surface water, and imported water for consumption by agriculture and natural vegetation on the landscape, and for potable and other uses within a supply-and-demand framework. MF-OWHM is based on the Farm Process for MODFLOW-2005 combined with Local Grid Refinement, Streamflow Routing, Surface-water Routing Process, Seawater Intrusion, Riparian Evapotranspiration, and the Newton-Raphson solver. MF-OWHM also includes linkages for deformation-, flow-, and head-dependent flows; additional observation and parameter options for higher-order calibrations; and redesigned code for facilitation of self-updating models and faster simulation run times. The next version of MF-OWHM, currently under development, will include a new surface-water operations module that simulates dynamic reservoir operations, the conduit flow process for karst aquifers and leaky pipe networks, a new subsidence and aquifer compaction package, and additional features and enhancements to enable more integration and cross communication between traditional MODFLOW packages. By retaining and tracking the water within the hydrosphere, MF-OWHM accounts for "all of the water everywhere and all of the time." This philosophy provides more confidence in the water accounting by the scientific community and provides the public a foundation needed to address wider classes of problems such as evaluation of conjunctive-use alternatives and sustainability analysis, including potential adaptation and mitigation strategies, and best management practices. By Scott E. Boyce and Randall T. Hanson

Scalable Nonlinear Solvers for Fully Implicit Coupled Nuclear Fuel Modeling. Final Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cai, Xiao-Chuan; Keyes, David; Yang, Chao

2014-09-29

The focus of the project is on the development and customization of some highly scalable domain decomposition based preconditioning techniques for the numerical solution of nonlinear, coupled systems of partial differential equations (PDEs) arising from nuclear fuel simulations. These high-order PDEs represent multiple interacting physical fields (for example, heat conduction, oxygen transport, solid deformation), each is modeled by a certain type of Cahn-Hilliard and/or Allen-Cahn equations. Most existing approaches involve a careful splitting of the fields and the use of field-by-field iterations to obtain a solution of the coupled problem. Such approaches have many advantages such as ease of implementationmore » since only single field solvers are needed, but also exhibit disadvantages. For example, certain nonlinear interactions between the fields may not be fully captured, and for unsteady problems, stable time integration schemes are difficult to design. In addition, when implemented on large scale parallel computers, the sequential nature of the field-by-field iterations substantially reduces the parallel efficiency. To overcome the disadvantages, fully coupled approaches have been investigated in order to obtain full physics simulations.« less

Further Conceptualizing Ethnic and Racial Identity Research: The Social Identity Approach and Its Dynamic Model.

PubMed

Verkuyten, Maykel

2016-11-01

This article proposes a further conceptualization of ethnic and racial identity (ERI) as a fundamental topic in developmental research. Adding to important recent efforts to conceptually integrate and synthesize this field, it is argued that ERI research will be enhanced by more fully considering the implications of the social identity approach. These implications include (a) the conceptualization of social identity, (b) the importance of identity motives, (c) systematic ways for theorizing and examining the critical role of situational and societal contexts, and (d) a dynamic model of the relation between ERI and context. These implications have not been fully considered in the developmental literature but offer important possibilities for moving the field forward in new directions. © 2016 The Author. Child Development © 2016 Society for Research in Child Development, Inc.

Approach to Modeling Boundary Layer Ingestion Using a Fully Coupled Propulsion-RANS Model

NASA Technical Reports Server (NTRS)

Gray, Justin S.; Mader, Charles A.; Kenway, Gaetan K. W.; Martins, Joaquim R. R. A.

2017-01-01

Airframe-propulsion integration concepts that use boundary layer ingestion have the potential to reduce aircraft fuel burn. One concept that has been recently explored is NASA's Starc-ABL aircraft configuration, which offers the potential for 12% mission fuel burn reduction by using a turbo-electric propulsion system with an aft-mounted electrically driven boundary layer ingestion propulsor. This large potential for improved performance motivates a more detailed study of the boundary layer ingestion propulsor design, but to date, analyses of boundary layer ingestion have used uncoupled methods. These methods account for only aerodynamic effects on the propulsion system or propulsion system effects on the aerodynamics, but not both simultaneously. This work presents a new approach for building fully coupled propulsive-aerodynamic models of boundary layer ingestion propulsion systems. A 1D thermodynamic cycle analysis is coupled to a RANS simulation to model the Starc-ABL aft propulsor at a cruise condition and the effects variation in propulsor design on performance are examined. The results indicates that both propulsion and aerodynamic effects contribute equally toward the overall performance and that the fully coupled model yields substantially different results compared to uncoupled. The most significant finding is that boundary layer ingestion, while offering substantial fuel burn savings, introduces throttle dependent aerodynamics effects that need to be accounted for. This work represents a first step toward the multidisciplinary design optimization of boundary layer ingestion propulsion systems.

Exact solution for the quench dynamics of a nested integrable system

NASA Astrophysics Data System (ADS)

Mestyán, Márton; Bertini, Bruno; Piroli, Lorenzo; Calabrese, Pasquale

2017-08-01

Integrable models provide an exact description for a wide variety of physical phenomena. For example nested integrable systems contain different species of interacting particles with a rich phenomenology in their collective behavior, which is the origin of the unconventional phenomenon of spin-charge separation. So far, however, most of the theoretical work in the study of non-equilibrium dynamics of integrable systems has focussed on models with an elementary (i.e. not nested) Bethe ansatz. In this work we explicitly investigate quantum quenches in nested integrable systems, by generalizing the application of the quench action approach. Specifically, we consider the spin-1 Lai-Sutherland model, described, in the thermodynamic limit, by the theory of two different species of Bethe-ansatz particles, each one forming an infinite number of bound states. We focus on the situation where the quench dynamics starts from a simple matrix product state for which the overlaps with the eigenstates of the Hamiltonian are known. We fully characterize the post-quench steady state and perform several consistency checks for the validity of our results. Finally, we provide predictions for the propagation of entanglement and mutual information after the quench, which can be used as signature of the quasi-particle content of the model.

Theoretical Innovations in Combustion Stability Research: Integrated Analysis and Computation

DTIC Science & Technology

2011-04-14

Quirk JJ, Shepherd JE (1997) An analytical model for direct initiation of gaseous detonation waves, in 21st International Symposium on Shock Waves...the initial vorticity thickness, hi is here performed over (x1, x3) planes and ∆U0 is the initial velocity difference across the layer. In all cases...Reynolds numbers were 1452, 1507 and 2004. Selle et al. [9] showed that this database is relevant for fully-turbulent flow modeling . VI. RESULTS In all

A Paradigm Shift From Brick and Mortar: Full-Time Nursing Faculty Off Campus.

PubMed

Beck, Marlene; Bradley, Holly B; Cook, Linda L; Leasca, Joslin B; Lampley, Tammy; Gatti-Petito, JoAnne

The organizational structure for the Master of Science in Nursing's online program at Sacred Heart University offers a remarkably different innovative faculty model. Full-time, doctorally prepared faculty reside in several different states and teach online but are fully integrated and immersed in all aspects of the college of nursing. This untraditional model, which has proven to be successful over time using best practices for online education, is replicable and offers an innovative option for online learning.

Testing a model of physical activity among mothers and fathers of young children: integrating self-determined motivation, planning, and the theory of planned behavior.

PubMed

Hamilton, Kyra; Cox, Stephen; White, Katherine M

2012-02-01

Parents are at risk for inactivity; however, research into understanding parental physical activity (PA) is scarce. We integrated self-determined motivation, planning, and the theory of planned behavior (TPB) to better understand parental PA. Parents (252 mothers, 206 fathers) completed a main questionnaire assessing measures underpinning these constructs and a 1-week follow-up of PA behavior to examine whether self-determined motivation indirectly influenced intention via the TPB variables (i.e., attitude, subjective norm, and perceived behavioral control) and intention indirectly influenced behavior via planning. We found self-determined motivation on intention was fully mediated by the TPB variables and intention on behavior was partially mediated by the planning variables. In addition, slight differences in the model's paths between the sexes were revealed. The results illustrate the range of important determinants of parental PA and provide support for the integrated model in explaining PA decision making as well as the importance of examining sex differences.

COREBA (cognition-oriented emergent behavior architecture)

NASA Astrophysics Data System (ADS)

Kwak, S. David

2000-06-01

Currently, many behavior implementation technologies are available for modeling human behaviors in Department of Defense (DOD) computerized systems. However, it is commonly known that any single currently adopted behavior implementation technology is not so capable of fully representing complex and dynamic human decision-making and cognition behaviors. The author views that the current situation can be greatly improved if multiple technologies are integrated within a well designed overarching architecture that amplifies the merits of each of the participating technologies while suppressing the limitations that are inherent with each of the technologies. COREBA uses an overarching behavior integration architecture that makes the multiple implementation technologies cooperate in a homogeneous environment while collectively transcending the limitations associated with the individual implementation technologies. Specifically, COREBA synergistically integrates Artificial Intelligence and Complex Adaptive System under Rational Behavior Model multi-level multi- paradigm behavior architecture. This paper will describe applicability of COREBA in DOD domain, behavioral capabilities and characteristics of COREBA and how the COREBA architectural integrates various behavior implementation technologies.

Specifications of insilicoML 1.0: a multilevel biophysical model description language.

PubMed

Asai, Yoshiyuki; Suzuki, Yasuyuki; Kido, Yoshiyuki; Oka, Hideki; Heien, Eric; Nakanishi, Masao; Urai, Takahito; Hagihara, Kenichi; Kurachi, Yoshihisa; Nomura, Taishin

2008-12-01

An extensible markup language format, insilicoML (ISML), version 0.1, describing multi-level biophysical models has been developed and available in the public domain. ISML is fully compatible with CellML 1.0, a model description standard developed by the IUPS Physiome Project, for enhancing knowledge integration and model sharing. This article illustrates the new specifications of ISML 1.0 that largely extend the capability of ISML 0.1. ISML 1.0 can describe various types of mathematical models, including ordinary/partial differential/difference equations representing the dynamics of physiological functions and the geometry of living organisms underlying the functions. ISML 1.0 describes a model using a set of functional elements (modules) each of which can specify mathematical expressions of the functions. Structural and logical relationships between any two modules are specified by edges, which allow modular, hierarchical, and/or network representations of the model. The role of edge-relationships is enriched by key words in order for use in constructing a physiological ontology. The ontology is further improved by the traceability of history of the model's development and by linking between different ISML models stored in the model's database using meta-information. ISML 1.0 is designed to operate with a model database and integrated environments for model development and simulations for knowledge integration and discovery.

A Fully Implantable, NFC Enabled, Continuous Interstitial Glucose Monitor

PubMed Central

Anabtawi, Nijad; Freeman, Sabrina; Ferzli, Rony

2017-01-01

This work presents an integrated system-on-chip (SoC) that forms the core of a long-term, fully implantable, battery assisted, passive continuous glucose monitor. It integrates an amperometric glucose sensor interface, a near field communication (NFC) wireless front-end and a fully digital switched mode power management unit for supply regulation and on board battery charging. It uses 13.56 MHz (ISM) band to harvest energy and backscatter data to an NFC reader. System was implemented in 14nm CMOS technology and validated with post layout simulations. PMID:28702512

A Fully Implantable, NFC Enabled, Continuous Interstitial Glucose Monitor.

PubMed

Anabtawi, Nijad; Freeman, Sabrina; Ferzli, Rony

2016-02-01

This work presents an integrated system-on-chip (SoC) that forms the core of a long-term, fully implantable, battery assisted, passive continuous glucose monitor. It integrates an amperometric glucose sensor interface, a near field communication (NFC) wireless front-end and a fully digital switched mode power management unit for supply regulation and on board battery charging. It uses 13.56 MHz (ISM) band to harvest energy and backscatter data to an NFC reader. System was implemented in 14nm CMOS technology and validated with post layout simulations.

Fully integrated carbon nanotube composite thin film strain sensors on flexible substrates for structural health monitoring

NASA Astrophysics Data System (ADS)

Burton, A. R.; Lynch, J. P.; Kurata, M.; Law, K. H.

2017-09-01

Multifunctional thin film materials have opened many opportunities for novel sensing strategies for structural health monitoring. While past work has established methods of optimizing multifunctional materials to exhibit sensing properties, comparatively less work has focused on their integration into fully functional sensing systems capable of being deployed in the field. This study focuses on the advancement of a scalable fabrication process for the integration of multifunctional thin films into a fully integrated sensing system. This is achieved through the development of an optimized fabrication process that can create a broad range of sensing systems using multifunctional materials. A layer-by-layer deposited multifunctional composite consisting of single walled carbon nanotubes (SWNT) in a polyvinyl alcohol and polysodium-4-styrene sulfonate matrix are incorporated with a lithography process to produce a fully integrated sensing system deposited on a flexible substrate. To illustrate the process, a strain sensing platform consisting of a patterned SWNT-composite thin film as a strain-sensitive element within an amplified Wheatstone bridge sensing circuit is presented. Strain sensing is selected because it presents many of the design and processing challenges that are core to patterning multifunctional thin film materials into sensing systems. Strain sensors fabricated on a flexible polyimide substrate are experimentally tested under cyclic loading using standard four-point bending coupons and a partial-scale steel frame assembly under lateral loading. The study reveals the material process is highly repeatable to produce fully integrated strain sensors with linearity and sensitivity exceeding 0.99 and 5 {{V}}/{ε }, respectively. The thin film strain sensors are robust and are capable of high strain measurements beyond 3000 μ {ε }.

Influence of the starting temperature of calorimetric measurements on the accuracy of determined magnetocaloric effect

DOE Office of Scientific and Technical Information (OSTI.GOV)

Moreno-Ramirez, L. M.; Franco, V.; Conde, A.

Availability of a restricted heat capacity data range has a clear influence on the accuracy of calculated magnetocaloric effect, as confirmed by both numerical simulations and experimental measurements. Simulations using the Bean-Rodbell model show that, in general, the approximated magnetocaloric effect curves calculated using a linear extrapolation of the data starting from a selected temperature point down to zero kelvin deviate in a non-monotonic way from those correctly calculated by fully integrating the data from near zero temperatures. However, we discovered that a particular temperature range exists where the approximated magnetocaloric calculation provides the same result as the fully integratedmore » one. These specific truncated intervals exist for both first and second order phase transitions and are the same for the adiabatic temperature change and magnetic entropy change curves. Here, the effect of this truncated integration in real samples was confirmed using heat capacity data of Gd metal and Gd 5Si 2Ge 2 compound measured from near zero temperatures.« less

Influence of the starting temperature of calorimetric measurements on the accuracy of determined magnetocaloric effect

DOE PAGES

Moreno-Ramirez, L. M.; Franco, V.; Conde, A.; ...

2018-02-27

Availability of a restricted heat capacity data range has a clear influence on the accuracy of calculated magnetocaloric effect, as confirmed by both numerical simulations and experimental measurements. Simulations using the Bean-Rodbell model show that, in general, the approximated magnetocaloric effect curves calculated using a linear extrapolation of the data starting from a selected temperature point down to zero kelvin deviate in a non-monotonic way from those correctly calculated by fully integrating the data from near zero temperatures. However, we discovered that a particular temperature range exists where the approximated magnetocaloric calculation provides the same result as the fully integratedmore » one. These specific truncated intervals exist for both first and second order phase transitions and are the same for the adiabatic temperature change and magnetic entropy change curves. Here, the effect of this truncated integration in real samples was confirmed using heat capacity data of Gd metal and Gd 5Si 2Ge 2 compound measured from near zero temperatures.« less

Integrating multimodal transport into cellulosic biofuel supply chain design under feedstock seasonality with a case study based on California.

PubMed

Xie, Fei; Huang, Yongxi; Eksioglu, Sandra

2014-01-01

A multistage, mixed integer programing model was developed that fully integrates multimodal transport into the cellulosic biofuel supply chain design under feedstock seasonality. Three transport modes are considered: truck, single railcar, and unit train. The goal is to minimize the total cost for infrastructure, feedstock harvesting, biofuel production, and transportation. Strategic decisions including the locations and capacities of transshipment hubs, biorefineries, and terminals and tactical decisions on system operations are optimized in an integrated manner. When the model was implemented to a case study of cellulosic ethanol production in California, it was found that trucks are convenient for short-haul deliveries while rails are more effective for long-haul transportation. Taking the advantage of these benefits, the multimodal transport provides more cost effective solutions than the single-mode transport (truck). Copyright © 2013 Elsevier Ltd. All rights reserved.

Horses for courses: analytical tools to explore planetary boundaries

NASA Astrophysics Data System (ADS)

van Vuuren, D. P.; Lucas, P. L.; Häyhä, T.; Cornell, S. E.; Stafford-Smith, M.

2015-09-01

There is a need for further integrated research on developing a set of sustainable development objectives, based on the proposed framework of planetary boundaries indicators. The relevant research questions are divided in this paper into four key categories, related to the underlying processes and selection of key indicators, understanding the impacts of different exposure levels and influence of connections between different types of impacts, a better understanding of different response strategies and the available options to implement changes. Clearly, different categories of scientific disciplines and associated models exist that can contribute to the necessary analysis, noting that the distinctions between them are fuzzy. In the paper, we both indicate how different models relate to the four categories of questions but also how further insights can be obtained by connecting the different disciplines (without necessarily fully integrating them). Research on integration can support planetary boundary quantification in a credible way, linking human drivers and social and biophysical impacts.

General practice, primary care, and health service psychology: concepts, competencies, and the Combined-Integrated model.

PubMed

Schulte, Timothy J; Isley, Elayne; Link, Nancy; Shealy, Craig N; Winfrey, LaPearl Logan

2004-10-01

The profession of psychology is being impacted profoundly by broader changes within the national system of health care, as mental and behavioral health services are being recognized as essential components of a comprehensive, preventive, and cost-efficient primary care system. To fully define and embrace this role, the discipline of professional psychology must develop a shared disciplinary identity of health service psychology and a generalized competency-based model for doctoral education and training. This very framework has been adopted by Combined-Integrated (C-I) doctoral programs in professional psychology, which train across the practice areas (clinical, counseling, and school psychology) to provide a general and integrative foundation for their students. Because C-I programs produce general practitioners who are competent to function within a variety of health service settings, this innovative training approach has great potential to educate and train psychologists for a changing health care marketplace. Copyright 2004 Wiley Periodicals, Inc.

Assessing sequential data assimilation techniques for integrating GRACE data into a hydrological model

NASA Astrophysics Data System (ADS)

Khaki, M.; Hoteit, I.; Kuhn, M.; Awange, J.; Forootan, E.; van Dijk, A. I. J. M.; Schumacher, M.; Pattiaratchi, C.

2017-09-01

The time-variable terrestrial water storage (TWS) products from the Gravity Recovery And Climate Experiment (GRACE) have been increasingly used in recent years to improve the simulation of hydrological models by applying data assimilation techniques. In this study, for the first time, we assess the performance of the most popular data assimilation sequential techniques for integrating GRACE TWS into the World-Wide Water Resources Assessment (W3RA) model. We implement and test stochastic and deterministic ensemble-based Kalman filters (EnKF), as well as Particle filters (PF) using two different resampling approaches of Multinomial Resampling and Systematic Resampling. These choices provide various opportunities for weighting observations and model simulations during the assimilation and also accounting for error distributions. Particularly, the deterministic EnKF is tested to avoid perturbing observations before assimilation (that is the case in an ordinary EnKF). Gaussian-based random updates in the EnKF approaches likely do not fully represent the statistical properties of the model simulations and TWS observations. Therefore, the fully non-Gaussian PF is also applied to estimate more realistic updates. Monthly GRACE TWS are assimilated into W3RA covering the entire Australia. To evaluate the filters performances and analyze their impact on model simulations, their estimates are validated by independent in-situ measurements. Our results indicate that all implemented filters improve the estimation of water storage simulations of W3RA. The best results are obtained using two versions of deterministic EnKF, i.e. the Square Root Analysis (SQRA) scheme and the Ensemble Square Root Filter (EnSRF), respectively, improving the model groundwater estimations errors by 34% and 31% compared to a model run without assimilation. Applying the PF along with Systematic Resampling successfully decreases the model estimation error by 23%.

The Modular Modeling System (MMS): A toolbox for water- and environmental-resources management

USGS Publications Warehouse

Leavesley, G.H.; Markstrom, S.L.; Viger, R.J.; Hay, L.E.; ,

2005-01-01

The increasing complexity of water- and environmental-resource problems require modeling approaches that incorporate knowledge from a broad range of scientific and software disciplines. To address this need, the U.S. Geological Survey (USGS) has developed the Modular Modeling System (MMS). MMS is an integrated system of computer software for model development, integration, and application. Its modular design allows a high level of flexibility and adaptability to enable modelers to incorporate their own software into a rich array of built-in models and modeling tools. These include individual process models, tightly coupled models, loosely coupled models, and fully- integrated decision support systems. A geographic information system (GIS) interface, the USGS GIS Weasel, has been integrated with MMS to enable spatial delineation and characterization of basin and ecosystem features, and to provide objective parameter-estimation methods for models using available digital data. MMS provides optimization and sensitivity-analysis tools to analyze model parameters and evaluate the extent to which uncertainty in model parameters affects uncertainty in simulation results. MMS has been coupled with the Bureau of Reclamation object-oriented reservoir and river-system modeling framework, RiverWare, to develop models to evaluate and apply optimal resource-allocation and management strategies to complex, operational decisions on multipurpose reservoir systems and watersheds. This decision support system approach has been developed, tested, and implemented in the Gunnison, Yakima, San Joaquin, Rio Grande, and Truckee River basins of the western United States. MMS is currently being coupled with the U.S. Forest Service model SIMulating Patterns and Processes at Landscape Scales (SIMPPLLE) to assess the effects of alternative vegetation-management strategies on a variety of hydrological and ecological responses. Initial development and testing of the MMS-SIMPPLLE integration is being conducted on the Colorado Plateau region of the western United Sates.

Optically transparent microwave screens based on engineered graphene layers.

PubMed

Grande, M; Bianco, G V; Vincenti, M A; de Ceglia, D; Capezzuto, P; Petruzzelli, V; Scalora, M; Bruno, G; D'Orazio, A

2016-10-03

We propose an innovative approach for the realization of a microwave absorber fully transparent in the optical regime. This device is based on the Salisbury screen configuration, which consists of a lossless spacer, sandwiched between two graphene sheets whose sheet resistances are different and properly engineered. Experimental results show that it is possible to achieve near-perfect electromagnetic absorption in the microwave X-band. These findings are fully supported by an analytical approach based on an equivalent circuital model. Engineering and integration of graphene sheets could facilitate the realization of innovative microwave absorbers with additional electromagnetic and optical functionalities that could circumvent some of the major limitations of opaque microwave absorbers.

Local control on precipitation in a fully coupled climate-hydrology model.

PubMed

Larsen, Morten A D; Christensen, Jens H; Drews, Martin; Butts, Michael B; Refsgaard, Jens C

2016-03-10

The ability to simulate regional precipitation realistically by climate models is essential to understand and adapt to climate change. Due to the complexity of associated processes, particularly at unresolved temporal and spatial scales this continues to be a major challenge. As a result, climate simulations of precipitation often exhibit substantial biases that affect the reliability of future projections. Here we demonstrate how a regional climate model (RCM) coupled to a distributed hydrological catchment model that fully integrates water and energy fluxes between the subsurface, land surface, plant cover and the atmosphere, enables a realistic representation of local precipitation. Substantial improvements in simulated precipitation dynamics on seasonal and longer time scales is seen for a simulation period of six years and can be attributed to a more complete treatment of hydrological sub-surface processes including groundwater and moisture feedback. A high degree of local influence on the atmosphere suggests that coupled climate-hydrology models have a potential for improving climate projections and the results further indicate a diminished need for bias correction in climate-hydrology impact studies.

Local control on precipitation in a fully coupled climate-hydrology model

PubMed Central

Larsen, Morten A. D.; Christensen, Jens H.; Drews, Martin; Butts, Michael B.; Refsgaard, Jens C.

2016-01-01

The ability to simulate regional precipitation realistically by climate models is essential to understand and adapt to climate change. Due to the complexity of associated processes, particularly at unresolved temporal and spatial scales this continues to be a major challenge. As a result, climate simulations of precipitation often exhibit substantial biases that affect the reliability of future projections. Here we demonstrate how a regional climate model (RCM) coupled to a distributed hydrological catchment model that fully integrates water and energy fluxes between the subsurface, land surface, plant cover and the atmosphere, enables a realistic representation of local precipitation. Substantial improvements in simulated precipitation dynamics on seasonal and longer time scales is seen for a simulation period of six years and can be attributed to a more complete treatment of hydrological sub-surface processes including groundwater and moisture feedback. A high degree of local influence on the atmosphere suggests that coupled climate-hydrology models have a potential for improving climate projections and the results further indicate a diminished need for bias correction in climate-hydrology impact studies. PMID:26960564

The 128-channel fully differential digital integrated neural recording and stimulation interface.

PubMed

Shahrokhi, Farzaneh; Abdelhalim, Karim; Serletis, Demitre; Carlen, Peter L; Genov, Roman

2010-06-01

We present a fully differential 128-channel integrated neural interface. It consists of an array of 8 X 16 low-power low-noise signal-recording and generation circuits for electrical neural activity monitoring and stimulation, respectively. The recording channel has two stages of signal amplification and conditioning with and a fully differential 8-b column-parallel successive approximation (SAR) analog-to-digital converter (ADC). The total measured power consumption of each recording channel, including the SAR ADC, is 15.5 ¿W. The measured input-referred noise is 6.08 ¿ Vrms over a 5-kHz bandwidth, resulting in a noise efficiency factor of 5.6. The stimulation channel performs monophasic or biphasic voltage-mode stimulation, with a maximum stimulation current of 5 mA and a quiescent power dissipation of 51.5 ¿W. The design is implemented in 0.35-¿m complementary metal-oxide semiconductor technology with the channel pitch of 200 ¿m for a total die size of 3.4 mm × 2.5 mm and a total power consumption of 9.33 mW. The neural interface was validated in in vitro recording of a low-Mg(2+)/high-K(+) epileptic seizure model in an intact hippocampus of a mouse.

A fully associative, nonisothermal, nonlinear kinematic, unified viscoplastic model for titanium alloys

NASA Astrophysics Data System (ADS)

Arnold, S. M.; Saleeb, A. F.; Castelli, M. G.

1995-05-01

Specific forms for both the Gibb's and complementary dissipation potentials are chosen such that a complete (i.e., fully associative) potential base multiaxial, nonisothermal unified viscoplastic model is obtained. This model possesses one tensorial internal state variable (that is, associated with dislocation substructure) and an evolutionary law that has nonlinear kinematic hardening and both thermal and strain induced recovery mechanisms. A unique aspect of the present model is the inclusion of nonlinear hardening through the use of a compliance operator, derived from the Gibb's potential, in the evolution law for the back stress. This nonlinear tensorial operator is significant in that it allows both the flow and evolutionary laws to be fully associative (and therefore easily integrated), greatly influences the multiaxial response under non-proportional loading paths, and in the case of nonisothermal histories, introduces an instantaneous thermal softening mechanism proportional to the rate of change in temperature. In addition to this nonlinear compliance operator, a new consistent, potential preserving, internal strain unloading criterion has been introduced to prevent abnormalities in the predicted stress-strain curves, which are present with nonlinear hardening formulations, during unloading and reversed loading of the external variables. The specific model proposed is characterized for a representative titanium alloy commonly used as the matrix material in SiC fiber reinforced composites, i.e., TIMETAL 21S. Verification of the proposed model is shown using 'specialized' non-standard isothermal and thermomechanical deformation tests.

A fully associative, nonisothermal, nonlinear kinematic, unified viscoplastic model for titanium alloys

NASA Technical Reports Server (NTRS)

Arnold, S. M.; Saleeb, A. F.; Castelli, M. G.

1995-01-01

Specific forms for both the Gibb's and complementary dissipation potentials are chosen such that a complete (i.e., fully associative) potential base multiaxial, nonisothermal unified viscoplastic model is obtained. This model possesses one tensorial internal state variable (that is, associated with dislocation substructure) and an evolutionary law that has nonlinear kinematic hardening and both thermal and strain induced recovery mechanisms. A unique aspect of the present model is the inclusion of nonlinear hardening through the use of a compliance operator, derived from the Gibb's potential, in the evolution law for the back stress. This nonlinear tensorial operator is significant in that it allows both the flow and evolutionary laws to be fully associative (and therefore easily integrated), greatly influences the multiaxial response under non-proportional loading paths, and in the case of nonisothermal histories, introduces an instantaneous thermal softening mechanism proportional to the rate of change in temperature. In addition to this nonlinear compliance operator, a new consistent, potential preserving, internal strain unloading criterion has been introduced to prevent abnormalities in the predicted stress-strain curves, which are present with nonlinear hardening formulations, during unloading and reversed loading of the external variables. The specific model proposed is characterized for a representative titanium alloy commonly used as the matrix material in SiC fiber reinforced composites, i.e., TIMETAL 21S. Verification of the proposed model is shown using 'specialized' non-standard isothermal and thermomechanical deformation tests.

Real-world hydrologic assessment of a fully-distributed hydrological model in a parallel computing environment

NASA Astrophysics Data System (ADS)

Vivoni, Enrique R.; Mascaro, Giuseppe; Mniszewski, Susan; Fasel, Patricia; Springer, Everett P.; Ivanov, Valeriy Y.; Bras, Rafael L.

2011-10-01

SummaryA major challenge in the use of fully-distributed hydrologic models has been the lack of computational capabilities for high-resolution, long-term simulations in large river basins. In this study, we present the parallel model implementation and real-world hydrologic assessment of the Triangulated Irregular Network (TIN)-based Real-time Integrated Basin Simulator (tRIBS). Our parallelization approach is based on the decomposition of a complex watershed using the channel network as a directed graph. The resulting sub-basin partitioning divides effort among processors and handles hydrologic exchanges across boundaries. Through numerical experiments in a set of nested basins, we quantify parallel performance relative to serial runs for a range of processors, simulation complexities and lengths, and sub-basin partitioning methods, while accounting for inter-run variability on a parallel computing system. In contrast to serial simulations, the parallel model speed-up depends on the variability of hydrologic processes. Load balancing significantly improves parallel speed-up with proportionally faster runs as simulation complexity (domain resolution and channel network extent) increases. The best strategy for large river basins is to combine a balanced partitioning with an extended channel network, with potential savings through a lower TIN resolution. Based on these advances, a wider range of applications for fully-distributed hydrologic models are now possible. This is illustrated through a set of ensemble forecasts that account for precipitation uncertainty derived from a statistical downscaling model.

True Concurrent Thermal Engineering Integrating CAD Model Building with Finite Element and Finite Difference Methods

NASA Technical Reports Server (NTRS)

Panczak, Tim; Ring, Steve; Welch, Mark

1999-01-01

Thermal engineering has long been left out of the concurrent engineering environment dominated by CAD (computer aided design) and FEM (finite element method) software. Current tools attempt to force the thermal design process into an environment primarily created to support structural analysis, which results in inappropriate thermal models. As a result, many thermal engineers either build models "by hand" or use geometric user interfaces that are separate from and have little useful connection, if any, to CAD and FEM systems. This paper describes the development of a new thermal design environment called the Thermal Desktop. This system, while fully integrated into a neutral, low cost CAD system, and which utilizes both FEM and FD methods, does not compromise the needs of the thermal engineer. Rather, the features needed for concurrent thermal analysis are specifically addressed by combining traditional parametric surface based radiation and FD based conduction modeling with CAD and FEM methods. The use of flexible and familiar temperature solvers such as SINDA/FLUINT (Systems Improved Numerical Differencing Analyzer/Fluid Integrator) is retained.

Bim-Gis Integrated Geospatial Information Model Using Semantic Web and Rdf Graphs

NASA Astrophysics Data System (ADS)

Hor, A.-H.; Jadidi, A.; Sohn, G.

2016-06-01

In recent years, 3D virtual indoor/outdoor urban modelling becomes a key spatial information framework for many civil and engineering applications such as evacuation planning, emergency and facility management. For accomplishing such sophisticate decision tasks, there is a large demands for building multi-scale and multi-sourced 3D urban models. Currently, Building Information Model (BIM) and Geographical Information Systems (GIS) are broadly used as the modelling sources. However, data sharing and exchanging information between two modelling domains is still a huge challenge; while the syntactic or semantic approaches do not fully provide exchanging of rich semantic and geometric information of BIM into GIS or vice-versa. This paper proposes a novel approach for integrating BIM and GIS using semantic web technologies and Resources Description Framework (RDF) graphs. The novelty of the proposed solution comes from the benefits of integrating BIM and GIS technologies into one unified model, so-called Integrated Geospatial Information Model (IGIM). The proposed approach consists of three main modules: BIM-RDF and GIS-RDF graphs construction, integrating of two RDF graphs, and query of information through IGIM-RDF graph using SPARQL. The IGIM generates queries from both the BIM and GIS RDF graphs resulting a semantically integrated model with entities representing both BIM classes and GIS feature objects with respect to the target-client application. The linkage between BIM-RDF and GIS-RDF is achieved through SPARQL endpoints and defined by a query using set of datasets and entity classes with complementary properties, relationships and geometries. To validate the proposed approach and its performance, a case study was also tested using IGIM system design.

Validation of Fatigue Modeling Predictions in Aviation Operations

NASA Technical Reports Server (NTRS)

Gregory, Kevin; Martinez, Siera; Flynn-Evans, Erin

2017-01-01

Bio-mathematical fatigue models that predict levels of alertness and performance are one potential tool for use within integrated fatigue risk management approaches. A number of models have been developed that provide predictions based on acute and chronic sleep loss, circadian desynchronization, and sleep inertia. Some are publicly available and gaining traction in settings such as commercial aviation as a means of evaluating flight crew schedules for potential fatigue-related risks. Yet, most models have not been rigorously evaluated and independently validated for the operations to which they are being applied and many users are not fully aware of the limitations in which model results should be interpreted and applied.

Beyond Between-Group Differences: Considering Race, Ethnicity, and Culture in Research on Positive Youth Development Programs

ERIC Educational Resources Information Center

Williams, Joanna L.; Deutsch, Nancy L.

2016-01-01

In this article, we explore how researchers can more fully consider and conceptualize the role of race and ethnicity in studies of youth development programs, with an emphasis on positive youth development (PYD). Such a focus can be integrated in a more meaningful way through the application of a theoretical model that provides a framework for…

Challenges to Providing End-of-Life Care to Low-Income Elders with Advanced Chronic Disease: Lessons Learned from a Model Program

ERIC Educational Resources Information Center

Kramer, Betty J.; Auer, Casey

2005-01-01

Purpose: This study explored the challenges in providing end-of-life care to low-income elders with multiple comorbid chronic conditions in a fully "integrated" managed care program, and it highlighted essential recommendations. Design and Methods: A case-study design was used that involved an extensive analysis of qualitative data from five focus…

DCERP Annual Technical Report 4: March 2010 - February 2011

DTIC Science & Technology

2011-05-01

of monitoring may be necessary to fully characterize and model the impact of major climatic events (e.g., tropical cyclones, major droughts ) and...stressors (past, present, and future) at local and regional scales; take account of extreme climatic events (e.g., hurricanes, droughts ); and integrate...the longleaf pine ( Pinus palustris), savannas, and pocosins (shrub bog) that dominate MCBCL’s terrestrial environments. Variation in the biota and

integrated Earth System Model

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jones, Andew; Di Vittorio, Alan; Collins, William

The integrated Earth system model (iESM) has been developed as a new tool for projecting the joint human/climate system. The iESM is based upon coupling an integrated assessment model (IAM) and an Earth system model (ESM) into a common modeling infrastructure. IAMs are the primary tool for describing the human-Earth system, including the sources of global greenhouse gases (GHGs) and short-lived species (SLS), land use and land cover change (LULCC), and other resource-related drivers of anthropogenic climate change. ESMs are the primary scientific tools for examining the physical, chemical, and biogeochemical impacts of human-induced changes to the climate system. Themore » iESM project integrates the economic and human-dimension modeling of an IAM and a fully coupled ESM within a single simulation system while maintaining the separability of each model if needed. Both IAM and ESM codes are developed and used by large communities and have been extensively applied in recent national and international climate assessments. By introducing heretofore-omitted feedbacks between natural and societal drivers, we can improve scientific understanding of the human-Earth system dynamics. Potential applications include studies of the interactions and feedbacks leading to the timing, scale, and geographic distribution of emissions trajectories and other human influences, corresponding climate effects, and the subsequent impacts of a changing climate on human and natural systems.« less

Model Based Optimization of Integrated Low Voltage DC-DC Converter for Energy Harvesting Applications

NASA Astrophysics Data System (ADS)

Jayaweera, H. M. P. C.; Muhtaroğlu, Ali

2016-11-01

A novel model based methodology is presented to determine optimal device parameters for the fully integrated ultra low voltage DC-DC converter for energy harvesting applications. The proposed model feasibly contributes to determine the maximum efficient number of charge pump stages to fulfill the voltage requirement of the energy harvester application. The proposed DC-DC converter based power consumption model enables the analytical derivation of the charge pump efficiency when utilized simultaneously with the known LC tank oscillator behavior under resonant conditions, and voltage step up characteristics of the cross-coupled charge pump topology. The verification of the model has been done using a circuit simulator. The optimized system through the established model achieves more than 40% maximum efficiency yielding 0.45 V output with single stage, 0.75 V output with two stages, and 0.9 V with three stages for 2.5 kΩ, 3.5 kΩ and 5 kΩ loads respectively using 0.2 V input.

Development of a Stirling System Dynamic Model With Enhanced Thermodynamics

NASA Technical Reports Server (NTRS)

Regan, Timothy F.; Lewandowski, Edward J.

2005-01-01

The Stirling Convertor System Dynamic Model developed at NASA Glenn Research Center is a software model developed from first principles that includes the mechanical and mounting dynamics, the thermodynamics, the linear alternator, and the controller of a free-piston Stirling power convertor, along with the end user load. As such it represents the first detailed modeling tool for fully integrated Stirling convertor-based power systems. The thermodynamics of the model were originally a form of the isothermal Stirling cycle. In some situations it may be desirable to improve the accuracy of the Stirling cycle portion of the model. An option under consideration is to enhance the SDM thermodynamics by coupling the model with Gedeon Associates Sage simulation code. The result will be a model that gives a more accurate prediction of the performance and dynamics of the free-piston Stirling convertor. A method of integrating the Sage simulation code with the System Dynamic Model is described. Results of SDM and Sage simulation are compared to test data. Model parameter estimation and model validation are discussed.

Development of a Stirling System Dynamic Model with Enhanced Thermodynamics

NASA Astrophysics Data System (ADS)

Regan, Timothy F.; Lewandowski, Edward J.

2005-02-01

The Stirling Convertor System Dynamic Model developed at NASA Glenn Research Center is a software model developed from first principles that includes the mechanical and mounting dynamics, the thermodynamics, the linear alternator, and the controller of a free-piston Stirling power convertor, along with the end user load. As such it represents the first detailed modeling tool for fully integrated Stirling convertor-based power systems. The thermodynamics of the model were originally a form of the isothermal Stirling cycle. In some situations it may be desirable to improve the accuracy of the Stirling cycle portion of the model. An option under consideration is to enhance the SDM thermodynamics by coupling the model with Gedeon Associates' Sage simulation code. The result will be a model that gives a more accurate prediction of the performance and dynamics of the free-piston Stirling convertor. A method of integrating the Sage simulation code with the System Dynamic Model is described. Results of SDM and Sage simulation are compared to test data. Model parameter estimation and model validation are discussed.

Modelling wetland-groundwater interactions in the boreal Kälväsvaara esker, Northern Finland

NASA Astrophysics Data System (ADS)

Jaros, Anna; Rossi, Pekka; Ronkanen, Anna-Kaisa; Kløve, Bjørn

2016-04-01

Many types of boreal peatland ecosystems such as alkaline fens, aapa mires and Fennoscandia spring fens rely on the presence of groundwater. In these ecosystems groundwater creates unique conditions for flora and fauna by providing water, nutrients and constant water temperature enriching local biodiversity. The groundwater-peatland interactions and their dynamics are not, however, in many cases fully understood and their measurement and quantification is difficult due to highly heterogeneous structure of peatlands and large spatial extend of these ecosystems. Understanding of these interactions and their changes due to anthropogenic impact on groundwater resources would benefit the protection of the groundwater dependent peatlands. The groundwater-peatland interactions were investigated using the fully-integrated physically-based groundwater-surface water code HydroGeoSphere in a case study of the Kälväsvaara esker aquifer, Northern Finland. The Kälväsvaara is a geologically complex esker and it is surrounded by vast aapa mire system including alkaline and springs fens. In addition, numerous small springs occur in the discharge zone of the esker. In order to quantify groundwater-peatland interactions a simple steady-state model was built and results were evaluated using expected trends and field measurements. The employed model reproduced relatively well spatially distributed hydrological variables such as soil water content, water depths and groundwater-surface water exchange fluxes within the wetland and esker areas. The wetlands emerged in simulations as a result of geological and topographical conditions. They could be identified by high saturation levels at ground surface and by presence of shallow ponded water over some areas. The model outputs exhibited also strong surface water-groundwater interactions in some parts of the aapa system. These areas were noted to be regions of substantial diffusive groundwater discharge by the earlier studies. In contrast, the simulations were not able to capture small scale point groundwater discharge i.e. springs. This reflects that modelling small scale groundwater input to wetland ecosystems can be challenging without detailed information on the aquifer and wetland geology. Overall, the good consistency between simulations and observations demonstrated that wetland-groundwater interactions can be studied using fully-integrated physically-based groundwater-surface water models.

Foundry fabricated photonic integrated circuit optical phase lock loop.

PubMed

Bałakier, Katarzyna; Fice, Martyn J; Ponnampalam, Lalitha; Graham, Chris S; Wonfor, Adrian; Seeds, Alwyn J; Renaud, Cyril C

2017-07-24

This paper describes the first foundry-based InP photonic integrated circuit (PIC) designed to work within a heterodyne optical phase locked loop (OPLL). The PIC and an external electronic circuit were used to phase-lock a single-line semiconductor laser diode to an incoming reference laser, with tuneable frequency offset from 4 GHz to 12 GHz. The PIC contains 33 active and passive components monolithically integrated on a single chip, fully demonstrating the capability of a generic foundry PIC fabrication model. The electronic part of the OPLL consists of commercially available RF components. This semi-packaged system stabilizes the phase and frequency of the integrated laser so that an absolute frequency, high-purity heterodyne signal can be generated when the OPLL is in operation, with phase noise lower than -100 dBc/Hz at 10 kHz offset from the carrier. This is the lowest phase noise level ever demonstrated by monolithically integrated OPLLs.

Experience, Challenges, and Opportunities of Being Fully Embedded in a User Group.

PubMed

Wu, Lin; Thornton, Joel

2017-01-01

Embedded librarian models can assume different forms and levels, depending on patron needs and a library's choice of delivery services. An academic health sciences library decided to enhance its service delivery model by integrating a librarian into the College of Pharmacy, approximately 250 miles away from the main library. This article describes the embedded librarian's first-year experience, challenges, and opportunities working as a library faculty in the college. The comparison of one-year recorded statistics on preembedded and postembedded activities demonstrated the effectiveness and impact of such an embedded librarian model.

Linear stability analysis of the three-dimensional thermally-driven ocean circulation: application to interdecadal oscillations

NASA Astrophysics Data System (ADS)

Huck, Thierry; Vallis, Geoffrey K.

2001-08-01

What can we learn from performing a linear stability analysis of the large-scale ocean circulation? Can we predict from the basic state the occurrence of interdecadal oscillations, such as might be found in a forward integration of the full equations of motion? If so, do the structure and period of the linearly unstable modes resemble those found in a forward integration? We pursue here a preliminary study of these questions for a case in idealized geometry, in which the full nonlinear behavior can also be explored through forward integrations. Specifically, we perform a three-dimensional linear stability analysis of the thermally-driven circulation of the planetary geostrophic equations. We examine the resulting eigenvalues and eigenfunctions, comparing them with the structure of the interdecadal oscillations found in the fully nonlinear model in various parameter regimes. We obtain a steady state by running the time-dependent, nonlinear model to equilibrium using restoring boundary conditions on surface temperature. If the surface heat fluxes are then diagnosed, and these values applied as constant flux boundary conditions, the nonlinear model switches into a state of perpetual, finite amplitude, interdecadal oscillations. We construct a linearized version of the model by empirically evaluating the tangent linear matrix at the steady state, under both restoring and constant-flux boundary conditions. An eigen-analysis shows there are no unstable eigenmodes of the linearized model with restoring conditions. In contrast, under constant flux conditions, we find a single unstable eigenmode that shows a striking resemblance to the fully-developed oscillations in terms of three-dimensional structure, period and growth rate. The mode may be damped through either surface restoring boundary conditions or sufficiently large horizontal tracer diffusion. The success of this simple numerical method in idealized geometry suggests applications in the study of the stability of the ocean circulation in more realistic configurations, and the possibility of predicting potential oceanic modes, even weakly damped, that might be excited by stochastic atmospheric forcing or mesoscale ocean eddies.

Lessons Learned from the Deployment of a Hydrologic Science Observations Data Model

NASA Astrophysics Data System (ADS)

Beran, B.; Valentine, D.; Zaslavsky, I.; van Ingen, C.

2007-12-01

The CUAHSI Hydrologic Information System project is developing information technology infrastructure to support hydrologic science. The CUAHSI Observations Data Model (ODM) is a data model to store hydrologic observations data in a system designed to optimize data retrieval for integrated analysis of information collected by multiple investigators. The ODM v1, provides a distinct view into what information the community has determined is important to store, and what data views the community. As we began to work with ODM v1, we discovered the problem with the approach of tightly linking the community views of data to the database model. Design decisions for ODM v1 hindered the ability to utilize the datamodel as an aggregated information catalog need for the cyberinfrastructure. Different development groups had different approaches to populating the datamodel, and handling the complexity. The approaches varied from populating the ODM with a bare minimum of constraints to creating a fully constrained datamodel. This made the integration of different tools, difficult. In the end, we decided to utilize the fully populate model which ensure maximum compatibility with the data sources. Groups also discovered that while the data model central concept was optimized for data retrieval of individual observation. In practice, the concept of data series is better to manage data, yet there is no link between data series and data value in ODM v1. We are beginning to develop ODM v2 as a series of profiles. By utilizing profiles, we intend to make the core information model smaller, more manageable, and simpler to understand and populate. We intend to keep the community semantics, improve the linkages between data series and data values, and enhance data discovery for the CUAHSI cyberinfrastructure.

Numerical Modeling of Self-Pressurization and Pressure Control by Thermodynamic Vent System in a Cryogenic Tank

NASA Technical Reports Server (NTRS)

Majumdar, Alok; Valenzuela, Juan; LeClair, Andre; Moder, Jeff

2015-01-01

This paper presents a numerical model of a system-level test bed - the multipurpose hydrogen test bed (MHTB) using Generalized Fluid System Simulation Program (GFSSP). MHTB is representative in size and shape of a fully integrated space transportation vehicle liquid hydrogen (LH2) propellant tank and was tested at Marshall Space Flight Center (MSFC) to generate data for cryogenic storage. GFSSP is a finite volume based network flow analysis software developed at MSFC and used for thermo-fluid analysis of propulsion systems. GFSSP has been used to model the self-pressurization and ullage pressure control by Thermodynamic Vent System (TVS). A TVS typically includes a Joule-Thompson (J-T) expansion device, a two-phase heat exchanger, and a mixing pump and spray to extract thermal energy from the tank without significant loss of liquid propellant. Two GFSSP models (Self-Pressurization & TVS) were separately developed and tested and then integrated to simulate the entire system. Self-Pressurization model consists of multiple ullage nodes, propellant node and solid nodes; it computes the heat transfer through Multi-Layer Insulation blankets and calculates heat and mass transfer between ullage and liquid propellant and ullage and tank wall. TVS model calculates the flow through J-T valve, heat exchanger and spray and vent systems. Two models are integrated by exchanging data through User Subroutines of both models. The integrated models results have been compared with MHTB test data of 50% fill level. Satisfactory comparison was observed between test and numerical predictions.

Bridging the divide: a model-data approach to Polar and Alpine microbiology.

PubMed

Bradley, James A; Anesio, Alexandre M; Arndt, Sandra

2016-03-01

Advances in microbial ecology in the cryosphere continue to be driven by empirical approaches including field sampling and laboratory-based analyses. Although mathematical models are commonly used to investigate the physical dynamics of Polar and Alpine regions, they are rarely applied in microbial studies. Yet integrating modelling approaches with ongoing observational and laboratory-based work is ideally suited to Polar and Alpine microbial ecosystems given their harsh environmental and biogeochemical characteristics, simple trophic structures, distinct seasonality, often difficult accessibility, geographical expansiveness and susceptibility to accelerated climate changes. In this opinion paper, we explain how mathematical modelling ideally complements field and laboratory-based analyses. We thus argue that mathematical modelling is a powerful tool for the investigation of these extreme environments and that fully integrated, interdisciplinary model-data approaches could help the Polar and Alpine microbiology community address some of the great research challenges of the 21st century (e.g. assessing global significance and response to climate change). However, a better integration of field and laboratory work with model design and calibration/validation, as well as a stronger focus on quantitative information is required to advance models that can be used to make predictions and upscale processes and fluxes beyond what can be captured by observations alone. © FEMS 2016.

Bridging the divide: a model-data approach to Polar and Alpine microbiology

PubMed Central

Bradley, James A.; Anesio, Alexandre M.; Arndt, Sandra

2016-01-01

Advances in microbial ecology in the cryosphere continue to be driven by empirical approaches including field sampling and laboratory-based analyses. Although mathematical models are commonly used to investigate the physical dynamics of Polar and Alpine regions, they are rarely applied in microbial studies. Yet integrating modelling approaches with ongoing observational and laboratory-based work is ideally suited to Polar and Alpine microbial ecosystems given their harsh environmental and biogeochemical characteristics, simple trophic structures, distinct seasonality, often difficult accessibility, geographical expansiveness and susceptibility to accelerated climate changes. In this opinion paper, we explain how mathematical modelling ideally complements field and laboratory-based analyses. We thus argue that mathematical modelling is a powerful tool for the investigation of these extreme environments and that fully integrated, interdisciplinary model-data approaches could help the Polar and Alpine microbiology community address some of the great research challenges of the 21st century (e.g. assessing global significance and response to climate change). However, a better integration of field and laboratory work with model design and calibration/validation, as well as a stronger focus on quantitative information is required to advance models that can be used to make predictions and upscale processes and fluxes beyond what can be captured by observations alone. PMID:26832206

Forecasting in an integrated surface water-ground water system: The Big Cypress Basin, South Florida

NASA Astrophysics Data System (ADS)

Butts, M. B.; Feng, K.; Klinting, A.; Stewart, K.; Nath, A.; Manning, P.; Hazlett, T.; Jacobsen, T.

2009-04-01

The South Florida Water Management District (SFWMD) manages and protects the state's water resources on behalf of 7.5 million South Floridians and is the lead agency in restoring America's Everglades - the largest environmental restoration project in US history. Many of the projects to restore and protect the Everglades ecosystem are part of the Comprehensive Everglades Restoration Plan (CERP). The region has a unique hydrological regime, with close connection between surface water and groundwater, and a complex managed drainage network with many structures. Added to the physical complexity are the conflicting needs of the ecosystem for protection and restoration, versus the substantial urban development with the accompanying water supply, water quality and flood control issues. In this paper a novel forecasting and real-time modelling system is presented for the Big Cypress Basin. The Big Cypress Basin includes 272 km of primary canals and 46 water control structures throughout the area that provide limited levels of flood protection, as well as water supply and environmental quality management. This system is linked to the South Florida Water Management District's extensive real-time (SCADA) data monitoring and collection system. Novel aspects of this system include the use of a fully distributed and integrated modeling approach and a new filter-based updating approach for accurately forecasting river levels. Because of the interaction between surface- and groundwater a fully integrated forecast modeling approach is required. Indeed, results for the Tropical Storm Fay in 2008, the groundwater levels show an extremely rapid response to heavy rainfall. Analysis of this storm also shows that updating levels in the river system can have a direct impact on groundwater levels.

A discontinuous Galerkin approach for conservative modeling of fully nonlinear and weakly dispersive wave transformations

NASA Astrophysics Data System (ADS)

Sharifian, Mohammad Kazem; Kesserwani, Georges; Hassanzadeh, Yousef

2018-05-01

This work extends a robust second-order Runge-Kutta Discontinuous Galerkin (RKDG2) method to solve the fully nonlinear and weakly dispersive flows, within a scope to simultaneously address accuracy, conservativeness, cost-efficiency and practical needs. The mathematical model governing such flows is based on a variant form of the Green-Naghdi (GN) equations decomposed as a hyperbolic shallow water system with an elliptic source term. Practical features of relevance (i.e. conservative modeling over irregular terrain with wetting and drying and local slope limiting) have been restored from an RKDG2 solver to the Nonlinear Shallow Water (NSW) equations, alongside new considerations to integrate elliptic source terms (i.e. via a fourth-order local discretization of the topography) and to enable local capturing of breaking waves (i.e. via adding a detector for switching off the dispersive terms). Numerical results are presented, demonstrating the overall capability of the proposed approach in achieving realistic prediction of nearshore wave processes involving both nonlinearity and dispersion effects within a single model.

Insights on the energy-water nexus through modeling of the integrated water cycle

NASA Astrophysics Data System (ADS)

Leung, L. R.; Li, H. Y.; Zhang, X.; Wan, W.; Voisin, N.; Leng, G.

2016-12-01

For sustainable energy planning, understanding the impacts of climate change, land use change, and water management is essential as they all exert notable controls on streamflow and stream temperature that influence energy production. An integrated water model representing river processes, irrigation water use and water management has been developed and coupled to a land surface model to investigate the energy-water nexus. Simulations driven by two climate change projections with the RCP 4.5 and RCP 8.5 emissions scenarios, with and without water management, are analyzed to evaluate the individual and combined effects of climate change and water management on streamflow and stream temperature. The simulations revealed important impacts of climate change and water management on both floods and droughts. The simulations also revealed the dynamics of competition between changes in water demand and water availability in the climate mitigation (RCP 4.5) and business as usual (RCP 8.5) scenarios that influence streamflow and stream temperature, with important consequences to energy production. The integrated water model is being implemented to the Accelerated Climate Modeling for Energy (ACME) to enable investigation of the energy-water nexus in the fully coupled Earth system.

Vulnerability Assessment of Water Supply Systems: Status, Gaps and Opportunities

NASA Astrophysics Data System (ADS)

Wheater, H. S.

2015-12-01

Conventional frameworks for assessing the impacts of climate change on water resource systems use cascades of climate and hydrological models to provide 'top-down' projections of future water availability, but these are subject to high uncertainty and are model and scenario-specific. Hence there has been recent interest in 'bottom-up' frameworks, which aim to evaluate system vulnerability to change in the context of possible future climate and/or hydrological conditions. Such vulnerability assessments are generic, and can be combined with updated information from top-down assessments as they become available. While some vulnerability methods use hydrological models to estimate water availability, fully bottom-up schemes have recently been proposed that directly map system vulnerability as a function of feasible changes in water supply characteristics. These use stochastic algorithms, based on reconstruction or reshuffling methods, by which multiple water supply realizations can be generated under feasible ranges of change in water supply conditions. The paper reports recent successes, and points to areas of future improvement. Advances in stochastic modeling and optimization can address some technical limitations in flow reconstruction, while various data mining and system identification techniques can provide possibilities to better condition realizations for consistency with top-down scenarios. Finally, we show that probabilistic and Bayesian frameworks together can provide a potential basis to combine information obtained from fully bottom-up analyses with projections available from climate and/or hydrological models in a fully integrated risk assessment framework for deep uncertainty.

A Consecutive Spray Printing Strategy to Construct and Integrate Diverse Supercapacitors on Various Substrates.

PubMed

Wang, Xinyu; Lu, Qiongqiong; Chen, Chen; Han, Mo; Wang, Qingrong; Li, Haixia; Niu, Zhiqiang; Chen, Jun

2017-08-30

The rapid development of printable electronic devices with flexible and wearable characteristics requires supercapacitor devices to be printable, light, thin, integrated macro- and micro-devices with flexibility. Herein, we developed a consecutive spray printing strategy to controllably construct and integrate diverse supercapacitors on various substrates. In such a strategy, all supercapacitor components are fully printable, and their thicknesses and shapes are well controlled. As a result, supercapacitors obtained by this strategy achieve diverse structures and shapes. In addition, different nanocarbon and pseudocapacitive materials are applicable for the fabrication of these diverse supercapacitors. Furthermore, the diverse supercapacitors can be readily constructed on various objects with planar, curved, or even rough surfaces (e.g., plastic film, glass, cloth, and paper). More importantly, the consecutive spray printing process can integrate several supercapacitors together in the perpendicular and parallel directions of one substrate by designing the structure of electrodes and separators. This enlightens the construction and integration of fully printable supercapacitors with diverse configurations to be compatible with fully printable electronics on various substrates.

The impact of pharmacy services on opioid prescribing in dental practice.

PubMed

Stewart, Autumn; Zborovancik, Kelsey J; Stiely, Kara L

To compare rates of dental opioid prescribing between periods of full and partial integration of pharmacy services and periods of no integration. This observational study used a retrospective chart review of opioid prescriptions written by dental providers practicing in a free dental clinic for the medically underserved over a period of 74 months. Pharmacy services were fully integrated into the practice model for 48 of the 74 months under study. During this time frame, all dental opioid orders required review by the pharmacy department before prescribing. Outcomes related to prescribing rates and errors were compared between groups, which were defined by the level of integrated pharmacy services. Demographic and prescription-specific data (drug name, dose, quantity, directions, professional designation of individual entering order) and clinic appointment data were collected and analyzed with the use of descriptive and inferential statistics. A total of 102 opioids were prescribed to 89 patients; hydrocodone-acetaminophen combination products were the most frequently used. Opioid prescribing rates were 5 times greater when pharmacy services were not integrated (P <0.001); and dentists were 81% less likely to prescribe opioids when pharmacy was fully integrated (odds ratio 0.19, 95% confidence interval 0.124-0.293; P <0.001). Frequency of hydrocodone use compared with other opioids did not decrease after the rescheduling of hydrocodone to a Schedule II controlled substance. The frequency of prescribing errors was not statistically different between groups, although there were numerically fewer errors with integrated pharmacy services. The literature reports that dentists are the third most frequent prescribers of opioids. The findings from this study suggest that collaboration between pharmacists and dentists has the potential to decrease opioid utilization in primary dental practice. Copyright © 2017 American Pharmacists Association®. Published by Elsevier Inc. All rights reserved.

Integrated Aeromechanics with Three-Dimensional Solid-Multibody Structures

NASA Technical Reports Server (NTRS)

Datta, Anubhav; Johnson, Wayne

2014-01-01

A full three-dimensional finite element-multibody structural dynamic solver is coupled to a three-dimensional Reynolds-averaged Navier-Stokes solver for the prediction of integrated aeromechanical stresses and strains on a rotor blade in forward flight. The objective is to lay the foundations of all major pieces of an integrated three-dimensional rotor dynamic analysis - from model construction to aeromechanical solution to stress/strain calculation. The primary focus is on the aeromechanical solution. Two types of three-dimensional CFD/CSD interfaces are constructed for this purpose with an emphasis on resolving errors from geometry mis-match so that initial-stage approximate structural geometries can also be effectively analyzed. A three-dimensional structural model is constructed as an approximation to a UH-60A-like fully articulated rotor. The aerodynamic model is identical to the UH-60A rotor. For preliminary validation measurements from a UH-60A high speed flight is used where CFD coupling is essential to capture the advancing side tip transonic effects. The key conclusion is that an integrated aeromechanical analysis is indeed possible with three-dimensional structural dynamics but requires a careful description of its geometry and discretization of its parts.

Aerodynamic Modeling of Transonic Aircraft Using Vortex Lattice Coupled with Transonic Small Disturbance for Conceptual Design

NASA Technical Reports Server (NTRS)

Chaparro, Daniel; Fujiwara, Gustavo E. C.; Ting, Eric; Nguyen, Nhan

2016-01-01

The need to rapidly scan large design spaces during conceptual design calls for computationally inexpensive tools such as the vortex lattice method (VLM). Although some VLM tools, such as Vorview have been extended to model fully-supersonic flow, VLM solutions are typically limited to inviscid, subcritical flow regimes. Many transport aircraft operate at transonic speeds, which limits the applicability of VLM for such applications. This paper presents a novel approach to correct three-dimensional VLM through coupling of two-dimensional transonic small disturbance (TSD) solutions along the span of an aircraft wing in order to accurately predict transonic aerodynamic loading and wave drag for transport aircraft. The approach is extended to predict flow separation and capture the attenuation of aerodynamic forces due to boundary layer viscosity by coupling the TSD solver with an integral boundary layer (IBL) model. The modeling framework is applied to the NASA General Transport Model (GTM) integrated with a novel control surface known as the Variable Camber Continuous Trailing Edge Flap (VCCTEF).

A Conformal, Fully-Conservative Approach for Predicting Blast Effects on Ground Vehicles

DTIC Science & Technology

2014-04-01

time integration  Approximate Riemann Fluxes (HLLE, HLLC) ◦ Robust mixture model for multi-material flows  Multiple Equations of State ◦ Perfect Gas...Loci/CHEM: Chemically reacting compressible flow solver . ◦ Currently in production use by NASA for the simulation of rocket motors, plumes, and...vehicles  Loci/DROPLET: Eulerian and Lagrangian multiphase solvers  Loci/STREAM: pressure-based solver ◦ Developed by Streamline Numerics and

EPE analysis of sub-N10 BEoL flow with and without fully self-aligned via using Coventor SEMulator3D

NASA Astrophysics Data System (ADS)

Franke, Joern-Holger; Gallagher, Matt; Murdoch, Gayle; Halder, Sandip; Juncker, Aurelie; Clark, William

2017-03-01

During the last few decades, the semiconductor industry has been able to scale device performance up while driving costs down. What started off as simple geometrical scaling, driven mostly by advances in lithography, has recently been accompanied by advances in processing techniques and in device architectures. The trend to combine efforts using process technology and lithography is expected to intensify, as further scaling becomes ever more difficult. One promising component of future nodes are "scaling boosters", i.e. processing techniques that enable further scaling. An indispensable component in developing these ever more complex processing techniques is semiconductor process modeling software. Visualization of complex 3D structures in SEMulator3D, along with budget analysis on film thicknesses, CD and etch budgets, allow process integrators to compare flows before any physical wafers are run. Hundreds of "virtual" wafers allow comparison of different processing approaches, along with EUV or DUV patterning options for defined layers and different overlay schemes. This "virtual fabrication" technology produces massively parallel process variation studies that would be highly time-consuming or expensive in experiment. Here, we focus on one particular scaling booster, the fully self-aligned via (FSAV). We compare metal-via-metal (mevia-me) chains with self-aligned and fully-self-aligned via's using a calibrated model for imec's N7 BEoL flow. To model overall variability, 3D Monte Carlo modeling of as many variability sources as possible is critical. We use Coventor SEMulator3D to extract minimum me-me distances and contact areas and show how fully self-aligned vias allow a better me-via distance control and tighter via-me contact area variability compared with the standard self-aligned via (SAV) approach.

Integrated Dynamic Gloabal Modeling of Land Use, Energy and Economic Growth

DOE Office of Scientific and Technical Information (OSTI.GOV)

Atul Jain, University of Illinois, Urbana-Champaign, IL

2009-10-14

The overall objective of this collaborative project is to integrate an existing general equilibrium energy-economic growth model with a biogeochemical cycles and biophysical models in order to more fully explore the potential contribution of land use-related activities to future emissions scenarios. Land cover and land use change activities, including deforestation, afforestation, and agriculture management, are important source of not only CO2, but also non-CO2 GHGs. Therefore, contribution of land-use emissions to total emissions of GHGs is important, and consequently their future trends are relevant to the estimation of climate change and its mitigation. This final report covers the full projectmore » period of the award, beginning May 2006, which includes a sub-contract to Brown University later transferred to the National Center for Atmospheric Research (NCAR) when Co-PI Brian O'Neill changed institutional affiliations.« less

Implementation of Laminate Theory Into Strain Rate Dependent Micromechanics Analysis of Polymer Matrix Composites

NASA Technical Reports Server (NTRS)

Goldberg, Robert K.

2000-01-01

A research program is in progress to develop strain rate dependent deformation and failure models for the analysis of polymer matrix composites subject to impact loads. Previously, strain rate dependent inelastic constitutive equations developed to model the polymer matrix were implemented into a mechanics of materials based micromechanics method. In the current work, the computation of the effective inelastic strain in the micromechanics model was modified to fully incorporate the Poisson effect. The micromechanics equations were also combined with classical laminate theory to enable the analysis of symmetric multilayered laminates subject to in-plane loading. A quasi-incremental trapezoidal integration method was implemented to integrate the constitutive equations within the laminate theory. Verification studies were conducted using an AS4/PEEK composite using a variety of laminate configurations and strain rates. The predicted results compared well with experimentally obtained values.

A New Occurrence Model for National Assessment of Undiscovered Volcanogenic Massive Sulfide Deposits

USGS Publications Warehouse

Shanks, W.C. Pat; Dusel-Bacon, Cynthia; Koski, Randolph; Morgan, Lisa A.; Mosier, Dan; Piatak, Nadine M.; Ridley, Ian; Seal, Robert R.; Schulz, Klaus J.; Slack, John F.; Thurston, Roland

2009-01-01

Volcanogenic massive sulfide (VMS) deposits are very significant current and historical resources of Cu-Pb-Zn-Au-Ag, are active exploration targets in several areas of the United States and potentially have significant environmental effects. This new USGS VMS deposit model provides a comprehensive review of deposit occurrence and ore genesis, and fully integrates recent advances in the understanding of active seafloor VMS-forming environments, and integrates consideration of geoenvironmental consequences of mining VMS deposits. Because VMS deposits exhibit a broad range of geological and geochemical characteristics, a suitable classification system is required to incorporate these variations into the mineral deposit model. We classify VMS deposits based on compositional variations in volcanic and sedimentary host rocks. The advantage of the classification method is that it provides a closer linkage between tectonic setting and lithostratigraphic assemblages, and an increased predictive capability during field-based studies.

Fully automated adipose tissue measurement on abdominal CT

NASA Astrophysics Data System (ADS)

Yao, Jianhua; Sussman, Daniel L.; Summers, Ronald M.

2011-03-01

Obesity has become widespread in America and has been associated as a risk factor for many illnesses. Adipose tissue (AT) content, especially visceral AT (VAT), is an important indicator for risks of many disorders, including heart disease and diabetes. Measuring adipose tissue (AT) with traditional means is often unreliable and inaccurate. CT provides a means to measure AT accurately and consistently. We present a fully automated method to segment and measure abdominal AT in CT. Our method integrates image preprocessing which attempts to correct for image artifacts and inhomogeneities. We use fuzzy cmeans to cluster AT regions and active contour models to separate subcutaneous and visceral AT. We tested our method on 50 abdominal CT scans and evaluated the correlations between several measurements.

Integrative modelling for One Health: pattern, process and participation

PubMed Central

Redding, D. W.; Wood, J. L. N.

2017-01-01

This paper argues for an integrative modelling approach for understanding zoonoses disease dynamics, combining process, pattern and participatory models. Each type of modelling provides important insights, but all are limited. Combining these in a ‘3P’ approach offers the opportunity for a productive conversation between modelling efforts, contributing to a ‘One Health’ agenda. The aim is not to come up with a composite model, but seek synergies between perspectives, encouraging cross-disciplinary interactions. We illustrate our argument with cases from Africa, and in particular from our work on Ebola virus and Lassa fever virus. Combining process-based compartmental models with macroecological data offers a spatial perspective on potential disease impacts. However, without insights from the ground, the ‘black box’ of transmission dynamics, so crucial to model assumptions, may not be fully understood. We show how participatory modelling and ethnographic research of Ebola and Lassa fever can reveal social roles, unsafe practices, mobility and movement and temporal changes in livelihoods. Together with longer-term dynamics of change in societies and ecologies, all can be important in explaining disease transmission, and provide important complementary insights to other modelling efforts. An integrative modelling approach therefore can offer help to improve disease control efforts and public health responses. This article is part of the themed issue ‘One Health for a changing world: zoonoses, ecosystems and human well-being’. PMID:28584172

Modelling surface water-groundwater interaction with a conceptual approach: model development and application in New Zealand

NASA Astrophysics Data System (ADS)

Yang, J.; Zammit, C.; McMillan, H. K.

2016-12-01

As in most countries worldwide, water management in lowland areas is a big concern for New Zealand due to its economic importance for water related human activities. As a result, the estimation of available water resources in these areas (e.g., for irrigation and water supply purpose) is crucial and often requires an understanding of complex hydrological processes, which are often characterized by strong interactions between surface water and groundwater (usually expressed as losing and gaining rivers). These processes are often represented and simulated using integrated physically based hydrological models. However models with physically based groundwater modules typically require large amount of non-readily available geologic and aquifer information and are computationally intensive. Instead, this paper presents a conceptual groundwater model that is fully integrated into New Zealand's national hydrological model TopNet based on TopModel concepts (Beven, 1992). Within this conceptual framework, the integrated model can simulate not only surface processes, but also groundwater processes and surface water-groundwater interaction processes (including groundwater flow, river-groundwater interaction, and groundwater interaction with external watersheds). The developed model was applied to two New Zealand catchments with different hydro-geological and climate characteristics (Pareora catchment in the Canterbury Plains and Grey catchment on the West Coast). Previous studies have documented strong interactions between the river and groundwater, based on the analysis of a large number of concurrent flow measurements and associated information along the river main stem. Application of the integrated hydrological model indicates flow simulation (compared to the original hydrological model conceptualisation) during low flow conditions are significantly improved and further insights on local river dynamics are gained. Due to its conceptual characteristics and low level of data requirement, the integrated model could be used at local and national scales to improve the simulation of hydrological processes in non-topographically driven areas (where groundwater processes are important), and to assess impact of climate change on the integrated hydrological cycle in these areas.

PHM Enabled Autonomous Propellant Loading Operations

NASA Technical Reports Server (NTRS)

Walker, Mark; Figueroa, Fernando

2017-01-01

The utility of Prognostics and Health Management (PHM) software capability applied to Autonomous Operations (AO) remains an active research area within aerospace applications. The ability to gain insight into which assets and subsystems are functioning properly, along with the derivation of confident predictions concerning future ability, reliability, and availability, are important enablers for making sound mission planning decisions. When coupled with software that fully supports mission planning and execution, an integrated solution can be developed that leverages state assessment and estimation for the purposes of delivering autonomous operations. The authors have been applying this integrated, model-based approach to the autonomous loading of cryogenic spacecraft propellants at Kennedy Space Center.

Technology for the product and process data base

NASA Technical Reports Server (NTRS)

Barnes, R. D.

1984-01-01

The computerized product and process data base is increasingly recognized to be the cornerstone component of an overall system aimed at the integrated automation of the industrial processes of a given company or enterprise. The technology needed to support these more effective computer integrated design and manufacturing methods, especially the concept of 3-D computer-sensible product definitions rather than engineering drawings, is not fully available and rationalized. Progress is being made, however, in bridging this technology gap with concentration on the modeling of sophisticated information and data structures, high-performance interactive user interfaces and comprehensive tools for managing the resulting computerized product definition and process data base.

Assessing Hydrologic Impacts of Land Configuration Changes Using an Integrated Hydrologic Model at the Rocky Flats Environmental Technology Site, Colorado

NASA Astrophysics Data System (ADS)

Prucha, R. H.; Dayton, C. S.; Hawley, C. M.

2002-12-01

The Rocky Flats Environmental Technology Site (RFETS) in Golden, Colorado, a former Department of Energy nuclear weapons manufacturing facility, is currently undergoing closure. The natural semi-arid interaction between surface and subsurface flow at RFETS is complex and complicated by the industrial modifications to the flow system. Using a substantial site data set, a distributed parameter, fully-integrated hydrologic model was developed to assess the hydrologic impact of different hypothetical site closure configurations on the current flow system and to better understand the integrated hydrologic behavior of the system. An integrated model with this level of detail has not been previously developed in a semi-arid area, and a unique, but comprehensive, approach was required to calibrate and validate the model. Several hypothetical scenarios were developed to simulate hydrologic effects of modifying different aspects of the site. For example, some of the simulated modifications included regrading the current land surface, changing the existing surface channel network, removing subsurface trenches and gravity drain flow systems, installing a slurry wall and geotechnical cover, changing the current vegetative cover, and converting existing buildings and pavement to permeable soil areas. The integrated flow model was developed using a rigorous physically-based code so that realistic design parameters can simulate these changes. This code also permitted evaluation of changes to complex integrated hydrologic system responses that included channelized and overland flow, pond levels, unsaturated zone storage, groundwater heads and flow directions, and integrated water balances for key areas. Results generally show that channel flow offsite decreases substantially for different scenarios, while groundwater heads generally increase within the reconfigured industrial area most of which is then discharged as evapotranspiration. These changes have significant implications to site closure and operation.

The Swiss Master in Chiropractic Medicine Curriculum: Preparing Graduates to Work Together With Medicine to Improve Patient Care.

PubMed

Humphreys, B Kim; Peterson, Cynthia K

2016-12-01

In 2007, chiropractic became 1 of the 5 medical professions in Switzerland. This required a new chiropractic program that was fully integrated within a Swiss medical school. The purpose of this article was to discuss the Master in Chiropractic Medicine (MChiroMed) program at the University of Zürich, including advantages, opportunities, and challenges. In 2008, the MChiroMed program began with its first student cohort. The MChiroMed program is a 6-year Bologna model 2-cycle (bachelor and master) "spiral curriculum," with the first 4 years being fully integrated within the medical curriculum. A review of the main features of the curriculum revealed the advantages, opportunities, and challenges of this program in comparison with other contemporary chiropractic educational programs. Advantages and opportunities include an integrated curriculum within a university, medical school, and musculoskeletal hospital, with their associated human and physical resources. Many opportunities exist for high-level research collaborations. The rigorous entrance qualifications and small student cohorts result in bright, motivated, and enthusiastic students; appropriate assessments; and timely feedback on academic and clinical subjects. Early patient contact in hospitals and clinical facilities encourages the integration of academic theory and clinical practice. The main challenges faced by this program include difficulty recruiting a sufficient number of students because of the rigorous entrance requirements and curriculum overload resulting from undertaking a full medical curriculum and chiropractic modules. The MChiroMed program is a unique chiropractic curriculum that integrates medical and chiropractic education within a spiral curriculum at a world-class Swiss university medical school. The expectation is that graduates, with their expanded diagnostic and therapeutic knowledge, skills, and experience, will become future experts in primary spine care in Switzerland. It is hoped that this curriculum model will be adopted by other countries and jurisdictions seeking to enhance the role of chiropractic in health care.

A Synthetic Vision Preliminary Integrated Safety Analysis

NASA Technical Reports Server (NTRS)

Hemm, Robert; Houser, Scott

2001-01-01

This report documents efforts to analyze a sample of aviation safety programs, using the LMI-developed integrated safety analysis tool to determine the change in system risk resulting from Aviation Safety Program (AvSP) technology implementation. Specifically, we have worked to modify existing system safety tools to address the safety impact of synthetic vision (SV) technology. Safety metrics include reliability, availability, and resultant hazard. This analysis of SV technology is intended to be part of a larger effort to develop a model that is capable of "providing further support to the product design and development team as additional information becomes available". The reliability analysis portion of the effort is complete and is fully documented in this report. The simulation analysis is still underway; it will be documented in a subsequent report. The specific goal of this effort is to apply the integrated safety analysis to SV technology. This report also contains a brief discussion of data necessary to expand the human performance capability of the model, as well as a discussion of human behavior and its implications for system risk assessment in this modeling environment.

Bridging the Engineering and Medicine Gap

NASA Technical Reports Server (NTRS)

Walton, M.; Antonsen, E.

2018-01-01

A primary challenge NASA faces is communication between the disparate entities of engineers and human system experts in life sciences. Clear communication is critical for exploration mission success from the perspective of both risk analysis and data handling. The engineering community uses probabilistic risk assessment (PRA) models to inform their own risk analysis and has extensive experience managing mission data, but does not always fully consider human systems integration (HSI). The medical community, as a part of HSI, has been working 1) to develop a suite of tools to express medical risk in quantitative terms that are relatable to the engineering approaches commonly in use, and 2) to manage and integrate HSI data with engineering data. This talk will review the development of the Integrated Medical Model as an early attempt to bridge the communication gap between the medical and engineering communities in the language of PRA. This will also address data communication between the two entities in the context of data management considerations of the Medical Data Architecture. Lessons learned from these processes will help identify important elements to consider in future communication and integration of these two groups.

One carbon cycle: Impacts of model integration, ecosystem process detail, model resolution, and initialization data, on projections of future climate mitigation strategies

NASA Astrophysics Data System (ADS)

Fisk, J.; Hurtt, G. C.; le page, Y.; Patel, P. L.; Chini, L. P.; Sahajpal, R.; Dubayah, R.; Thomson, A. M.; Edmonds, J.; Janetos, A. C.

2013-12-01

Integrated assessment models (IAMs) simulate the interactions between human and natural systems at a global scale, representing a broad suite of phenomena across the global economy, energy system, land-use, and carbon cycling. Most proposed climate mitigation strategies rely on maintaining or enhancing the terrestrial carbon sink as a substantial contribution to restrain the concentration of greenhouse gases in the atmosphere, however most IAMs rely on simplified regional representations of terrestrial carbon dynamics. Our research aims to reduce uncertainties associated with forest modeling within integrated assessments, and to quantify the impacts of climate change on forest growth and productivity for integrated assessments of terrestrial carbon management. We developed the new Integrated Ecosystem Demography (iED) to increase terrestrial ecosystem process detail, resolution, and the utilization of remote sensing in integrated assessments. iED brings together state-of-the-art models of human society (GCAM), spatial land-use patterns (GLM) and terrestrial ecosystems (ED) in a fully coupled framework. The major innovative feature of iED is a consistent, process-based representation of ecosystem dynamics and carbon cycle throughout the human, terrestrial, land-use, and atmospheric components. One of the most challenging aspects of ecosystem modeling is to provide accurate initialization of land surface conditions to reflect non-equilibrium conditions, i.e., the actual successional state of the forest. As all plants in ED have an explicit height, it is one of the few ecosystem models that can be initialized directly with vegetation height data. Previous work has demonstrated that ecosystem model resolution and initialization data quality have a large effect on flux predictions at continental scales. Here we use a factorial modeling experiment to quantify the impacts of model integration, process detail, model resolution, and initialization data on projections of future climate mitigation strategies. We find substantial effects on key integrated assessment projections including the magnitude of emissions to mitigate, the economic value of ecosystem carbon storage, future land-use patterns, food prices and energy technology.

Experiences of Community-Living Older Adults Receiving Integrated Care Based on the Chronic Care Model: A Qualitative Study

PubMed Central

Spoorenberg, Sophie L. W.; Wynia, Klaske; Fokkens, Andrea S.; Slotman, Karin; Kremer, Hubertus P. H.; Reijneveld, Sijmen A.

2015-01-01

Background Integrated care models aim to solve the problem of fragmented and poorly coordinated care in current healthcare systems. These models aim to be patient-centered by providing continuous and coordinated care and by considering the needs and preferences of patients. The objective of this study was to evaluate the opinions and experiences of community-living older adults with regard to integrated care and support, along with the extent to which it meets their health and social needs. Methods Semi-structured interviews were conducted with 23 older adults receiving integrated care and support through “Embrace,” an integrated care model for community-living older adults that is based on the Chronic Care Model and a population health management model. Embrace is currently fully operational in the northern region of the Netherlands. Data analysis was based on the grounded theory approach. Results Responses of participants concerned two focus areas: 1) Experiences with aging, with the themes “Struggling with health,” “Increasing dependency,” “Decreasing social interaction,” “Loss of control,” and “Fears;” and 2) Experiences with Embrace, with the themes “Relationship with the case manager,” “Interactions,” and “Feeling in control, safe, and secure”. The prospect of becoming dependent and losing control was a key concept in the lives of the older adults interviewed. Embrace reinforced the participants’ ability to stay in control, even if they were dependent on others. Furthermore, participants felt safe and secure, in contrast to the fears of increasing dependency within the standard care system. Conclusion The results indicate that integrated care and support provided through Embrace met the health and social needs of older adults, who were coping with the consequences of aging. PMID:26489096

Experiences of Community-Living Older Adults Receiving Integrated Care Based on the Chronic Care Model: A Qualitative Study.

PubMed

Spoorenberg, Sophie L W; Wynia, Klaske; Fokkens, Andrea S; Slotman, Karin; Kremer, Hubertus P H; Reijneveld, Sijmen A

2015-01-01

Integrated care models aim to solve the problem of fragmented and poorly coordinated care in current healthcare systems. These models aim to be patient-centered by providing continuous and coordinated care and by considering the needs and preferences of patients. The objective of this study was to evaluate the opinions and experiences of community-living older adults with regard to integrated care and support, along with the extent to which it meets their health and social needs. Semi-structured interviews were conducted with 23 older adults receiving integrated care and support through "Embrace," an integrated care model for community-living older adults that is based on the Chronic Care Model and a population health management model. Embrace is currently fully operational in the northern region of the Netherlands. Data analysis was based on the grounded theory approach. Responses of participants concerned two focus areas: 1) Experiences with aging, with the themes "Struggling with health," "Increasing dependency," "Decreasing social interaction," "Loss of control," and "Fears;" and 2) Experiences with Embrace, with the themes "Relationship with the case manager," "Interactions," and "Feeling in control, safe, and secure". The prospect of becoming dependent and losing control was a key concept in the lives of the older adults interviewed. Embrace reinforced the participants' ability to stay in control, even if they were dependent on others. Furthermore, participants felt safe and secure, in contrast to the fears of increasing dependency within the standard care system. The results indicate that integrated care and support provided through Embrace met the health and social needs of older adults, who were coping with the consequences of aging.

Compressive Spectral Method for the Simulation of the Nonlinear Gravity Waves

PubMed Central

Bayındır, Cihan

2016-01-01

In this paper an approach for decreasing the computational effort required for the spectral simulations of the fully nonlinear ocean waves is introduced. The proposed approach utilizes the compressive sampling algorithm and depends on the idea of using a smaller number of spectral components compared to the classical spectral method. After performing the time integration with a smaller number of spectral components and using the compressive sampling technique, it is shown that the ocean wave field can be reconstructed with a significantly better efficiency compared to the classical spectral method. For the sparse ocean wave model in the frequency domain the fully nonlinear ocean waves with Jonswap spectrum is considered. By implementation of a high-order spectral method it is shown that the proposed methodology can simulate the linear and the fully nonlinear ocean waves with negligible difference in the accuracy and with a great efficiency by reducing the computation time significantly especially for large time evolutions. PMID:26911357

Inside black holes with synchronized hair

NASA Astrophysics Data System (ADS)

Brihaye, Yves; Herdeiro, Carlos; Radu, Eugen

2016-09-01

Recently, various examples of asymptotically flat, rotating black holes (BHs) with synchronized hair have been explicitly constructed, including Kerr BHs with scalar or Proca hair, and Myers-Perry BHs with scalar hair and a mass gap, showing there is a general mechanism at work. All these solutions have been found numerically, integrating the fully non-linear field equations of motion from the event horizon outwards. Here, we address the spacetime geometry of these solutions inside the event horizon. Firstly, we provide arguments, within linear theory, that there is no regular inner horizon for these solutions. Then, we address this question fully non-linearly, using as a tractable model five dimensional, equal spinning, Myers-Perry hairy BHs. We find that, for non-extremal solutions: (1) the inside spacetime geometry in the vicinity of the event horizon is smooth and the equations of motion can be integrated inwards; (2) before an inner horizon is reached, the spacetime curvature grows (apparently) without bound. In all cases, our results suggest the absence of a smooth Cauchy horizon, beyond which the metric can be extended, for hairy BHs with synchronized hair.

Mm-size bistable zipping dielectric elastomer actuators for integrated microfluidics

NASA Astrophysics Data System (ADS)

Maffli, Luc; Rosset, Samuel; Shea, Herbert R.

2013-04-01

We report on a new structure of Dielectric Elastomer Actuators (DEAs) called zipping DEAs, which have a set of unique characteristics that are a good match for the requirements of electrically-powered integrated microfluidic pumping and/or valving units as well as Braille displays. The zipping DEAs operate by pulling electrostatically an elastomer membrane in contact with the rigid sidewalls of a sloped chamber. In this work, we report on fully functional mm-size zipping DEAs that demonstrate a complete sealing of the chamber sidewalls and a tunable bistable behavior, and compare the measurements with an analytical model. Compared to our first generation of devices, we are able vary the sidewall angle and benefit therefore from more flexibility to study the requirements to make fully functional actuators. In particular, we show that with Nusil CF19 as membrane material (1.2 MPa Young's modulus), it is possible to zip completely 2.3 mm diameter chambers with 15° and 21° sidewalls angle equibiaxially prestretched to λ0=1.12 and 15° chambers with λ0=1.27.

General Multimechanism Reversible-Irreversible Time-Dependent Constitutive Deformation Model Being Developed

NASA Technical Reports Server (NTRS)

Saleeb, A. F.; Arnold, Steven M.

2001-01-01

Since most advanced material systems (for example metallic-, polymer-, and ceramic-based systems) being currently researched and evaluated are for high-temperature airframe and propulsion system applications, the required constitutive models must account for both reversible and irreversible time-dependent deformations. Furthermore, since an integral part of continuum-based computational methodologies (be they microscale- or macroscale-based) is an accurate and computationally efficient constitutive model to describe the deformation behavior of the materials of interest, extensive research efforts have been made over the years on the phenomenological representations of constitutive material behavior in the inelastic analysis of structures. From a more recent and comprehensive perspective, the NASA Glenn Research Center in conjunction with the University of Akron has emphasized concurrently addressing three important and related areas: that is, 1) Mathematical formulation; 2) Algorithmic developments for updating (integrating) the external (e.g., stress) and internal state variables; 3) Parameter estimation for characterizing the model. This concurrent perspective to constitutive modeling has enabled the overcoming of the two major obstacles to fully utilizing these sophisticated time-dependent (hereditary) constitutive models in practical engineering analysis. These obstacles are: 1) Lack of efficient and robust integration algorithms; 2) Difficulties associated with characterizing the large number of required material parameters, particularly when many of these parameters lack obvious or direct physical interpretations.

PCSIM: A Parallel Simulation Environment for Neural Circuits Fully Integrated with Python

PubMed Central

Pecevski, Dejan; Natschläger, Thomas; Schuch, Klaus

2008-01-01

The Parallel Circuit SIMulator (PCSIM) is a software package for simulation of neural circuits. It is primarily designed for distributed simulation of large scale networks of spiking point neurons. Although its computational core is written in C++, PCSIM's primary interface is implemented in the Python programming language, which is a powerful programming environment and allows the user to easily integrate the neural circuit simulator with data analysis and visualization tools to manage the full neural modeling life cycle. The main focus of this paper is to describe PCSIM's full integration into Python and the benefits thereof. In particular we will investigate how the automatically generated bidirectional interface and PCSIM's object-oriented modular framework enable the user to adopt a hybrid modeling approach: using and extending PCSIM's functionality either employing pure Python or C++ and thus combining the advantages of both worlds. Furthermore, we describe several supplementary PCSIM packages written in pure Python and tailored towards setting up and analyzing neural simulations. PMID:19543450

Biomaterials for integration with 3-D bioprinting.

PubMed

Skardal, Aleksander; Atala, Anthony

2015-03-01

Bioprinting has emerged in recent years as an attractive method for creating 3-D tissues and organs in the laboratory, and therefore is a promising technology in a number of regenerative medicine applications. It has the potential to (i) create fully functional replacements for damaged tissues in patients, and (ii) rapidly fabricate small-sized human-based tissue models, or organoids, for diagnostics, pathology modeling, and drug development. A number of bioprinting modalities have been explored, including cellular inkjet printing, extrusion-based technologies, soft lithography, and laser-induced forward transfer. Despite the innovation of each of these technologies, successful implementation of bioprinting relies heavily on integration with compatible biomaterials that are responsible for supporting the cellular components during and after biofabrication, and that are compatible with the bioprinting device requirements. In this review, we will evaluate a variety of biomaterials, such as curable synthetic polymers, synthetic gels, and naturally derived hydrogels. Specifically we will describe how they are integrated with the bioprinting technologies above to generate bioprinted constructs with practical application in medicine.

Framework for Infectious Disease Analysis: A comprehensive and integrative multi-modeling approach to disease prediction and management.

PubMed

Erraguntla, Madhav; Zapletal, Josef; Lawley, Mark

2017-12-01

The impact of infectious disease on human populations is a function of many factors including environmental conditions, vector dynamics, transmission mechanics, social and cultural behaviors, and public policy. A comprehensive framework for disease management must fully connect the complete disease lifecycle, including emergence from reservoir populations, zoonotic vector transmission, and impact on human societies. The Framework for Infectious Disease Analysis is a software environment and conceptual architecture for data integration, situational awareness, visualization, prediction, and intervention assessment. Framework for Infectious Disease Analysis automatically collects biosurveillance data using natural language processing, integrates structured and unstructured data from multiple sources, applies advanced machine learning, and uses multi-modeling for analyzing disease dynamics and testing interventions in complex, heterogeneous populations. In the illustrative case studies, natural language processing from social media, news feeds, and websites was used for information extraction, biosurveillance, and situation awareness. Classification machine learning algorithms (support vector machines, random forests, and boosting) were used for disease predictions.

Benchmarking the Integration of WAVEWATCH III Results into HAZUS-MH: Preliminary Results

NASA Technical Reports Server (NTRS)

Berglund, Judith; Holland, Donald; McKellip, Rodney; Sciaudone, Jeff; Vickery, Peter; Wang, Zhanxian; Ying, Ken

2005-01-01

The report summarizes the results from the preliminary benchmarking activities associated with the use of WAVEWATCH III (WW3) results in the HAZUS-MH MR1 flood module. Project partner Applied Research Associates (ARA) is integrating the WW3 model into HAZUS. The current version of HAZUS-MH predicts loss estimates from hurricane-related coastal flooding by using values of surge only. Using WW3, wave setup can be included with surge. Loss estimates resulting from the use of surge-only and surge-plus-wave-setup were compared. This benchmarking study is preliminary because the HAZUS-MH MR1 flood module was under development at the time of the study. In addition, WW3 is not scheduled to be fully integrated with HAZUS-MH and available for public release until 2008.

The challenge of causal inference in gene-environment interaction research: leveraging research designs from the social sciences.

PubMed

Fletcher, Jason M; Conley, Dalton

2013-10-01

The integration of genetics and the social sciences will lead to a more complex understanding of the articulation between social and biological processes, although the empirical difficulties inherent in this integration are large. One key challenge is the implications of moving "outside the lab" and away from the experimental tools available for research with model organisms. Social science research methods used to examine human behavior in nonexperimental, real-world settings to date have not been fully taken advantage of during this disciplinary integration, especially in the form of gene-environment interaction research. This article outlines and provides examples of several prominent research designs that should be used in gene-environment research and highlights a key benefit to geneticists of working with social scientists.

Discretely Integrated Condition Event (DICE) Simulation for Pharmacoeconomics.

PubMed

Caro, J Jaime

2016-07-01

Several decision-analytic modeling techniques are in use for pharmacoeconomic analyses. Discretely integrated condition event (DICE) simulation is proposed as a unifying approach that has been deliberately designed to meet the modeling requirements in a straightforward transparent way, without forcing assumptions (e.g., only one transition per cycle) or unnecessary complexity. At the core of DICE are conditions that represent aspects that persist over time. They have levels that can change and many may coexist. Events reflect instantaneous occurrences that may modify some conditions or the timing of other events. The conditions are discretely integrated with events by updating their levels at those times. Profiles of determinant values allow for differences among patients in the predictors of the disease course. Any number of valuations (e.g., utility, cost, willingness-to-pay) of conditions and events can be applied concurrently in a single run. A DICE model is conveniently specified in a series of tables that follow a consistent format and the simulation can be implemented fully in MS Excel, facilitating review and validation. DICE incorporates both state-transition (Markov) models and non-resource-constrained discrete event simulation in a single formulation; it can be executed as a cohort or a microsimulation; and deterministically or stochastically.

Implicit-Explicit Time Integration Methods for Non-hydrostatic Atmospheric Models

NASA Astrophysics Data System (ADS)

Gardner, D. J.; Guerra, J. E.; Hamon, F. P.; Reynolds, D. R.; Ullrich, P. A.; Woodward, C. S.

2016-12-01

The Accelerated Climate Modeling for Energy (ACME) project is developing a non-hydrostatic atmospheric dynamical core for high-resolution coupled climate simulations on Department of Energy leadership class supercomputers. An important factor in computational efficiency is avoiding the overly restrictive time step size limitations of fully explicit time integration methods due to the stiffest modes present in the model (acoustic waves). In this work we compare the accuracy and performance of different Implicit-Explicit (IMEX) splittings of the non-hydrostatic equations and various Additive Runge-Kutta (ARK) time integration methods. Results utilizing the Tempest non-hydrostatic atmospheric model and the ARKode package show that the choice of IMEX splitting and ARK scheme has a significant impact on the maximum stable time step size as well as solution quality. Horizontally Explicit Vertically Implicit (HEVI) approaches paired with certain ARK methods lead to greatly improved runtimes. With effective preconditioning IMEX splittings that incorporate some implicit horizontal dynamics can be competitive with HEVI results. This work was performed under the auspices of the U.S. Department of Energy by Lawrence Livermore National Laboratory under Contract DE-AC52-07NA27344. LLNL-ABS-699187

Integrated Blowoff and Breakup Calculations for Asteroid Deflection by Nuclear Ablation

NASA Astrophysics Data System (ADS)

Bruck Syal, M.; Owen, M.; Dearborn, D. S.; Miller, P. L.

2016-12-01

When the warning timing is short, hazardous asteroids or comets can only be deflected off of an Earth-impacting trajectory by a nuclear device [1]. Here we model asteroid response to a standoff nuclear explosion, a problem which requires sub-millimeter spatial resolution at the body's surface to fully capture x-ray energy deposition. The first stage of the calculation focuses on modeling blowoff momentum from vaporized material, using a problem domain confined to the uppermost surface of the asteroid. Once the blowoff momentum transfer process is complete, the problem is remapped into a coarser resolution and the remainder of the asteroid body is added to the calculation, so that asteroid response can be tracked over longer timescales. This two-stage approach enables an integrated assessment of both the efficacy of momentum delivery and damage incurred by the bulk of the asteroid. Investigating the degree of post-ablation fracture, fragmentation, and fragment dispersion is necessary for modeling the outcomes of cases intended to fully fragment and disperse the body (disruption), as well as cases where the bulk of the asteroid should remain intact (deflection). We begin with 500-m spherical asteroids but also extend our analysis to radar-derived asteroid shape models. [1] Dearborn, D.S.P., Miller, P.L., 2014. Deflecting or Disrupting a Threatening Object, in: Pelton, J.N., Allahdadi, F. (Eds.), Handbook of Cosmic Hazards and Planetary Defense, Springer. This work was performed under the auspices of the U.S. Department of Energy by Lawrence Livermore National Laboratory under Contract DE-AC52- 07NA27344. LLNL-ABS-699631.

Toward a unified account of comprehension and production in language development.

PubMed

McCauley, Stewart M; Christiansen, Morten H

2013-08-01

Although Pickering & Garrod (P&G) argue convincingly for a unified system for language comprehension and production, they fail to explain how such a system might develop. Using a recent computational model of language acquisition as an example, we sketch a developmental perspective on the integration of comprehension and production. We conclude that only through development can we fully understand the intertwined nature of comprehension and production in adult processing.

Accelerator Technology Division: Annual Report FY 1990

DTIC Science & Technology

1991-05-01

new version of PARMTEQ that includes 3-D space - charge and image- charge effects in the Figure 2.4. Preliminary concept for the SSC RFQ Linac 25...developing a better space - charge model based on the work of Sachercr. We have successfully demonstrated the ability to include off-axis effects in...a way fully consistent with the space - charge forces. Modifying BEDLAM to include these effects will leave almost all of the code (the integrator

The Army Did Not Fully Document Procedures for Processing Wholesale Equipment in Kuwait

DTIC Science & Technology

2016-02-24

accountability , integrity, and efficiency; advises the Secretary of Defense and Congress; and informs the public. Vision Our vision is to be a model oversight...property accountability in support of Operation Inherent Resolve. Findings Army Field Support Battalion (AFSBn)–Kuwait generally had effective...established and equipment moving into and out of Camp Arifjan is properly accounted for and maintained. During the audit, we also observed a lack of physical

Integrating Experimentation, Modeling, and Visualization Through Full-Field Methods (Preprint)

DTIC Science & Technology

2009-04-01

including fatigue, fatigue-crack growth, tribology , fracture toughness, Figure 1. Full-field, in-plane, maximum principal stress in a fully lamellar...studied, and 3) the correlation between 1) and 2). The emphases in this paper will be on the first and second areas, but the need for work in the third ...problems, concentrating on displacements rather than strains is appropriate for this work. The top figure shows the overall displacements, after rigid- body

Defense Coastal/Estuarine Research Program (DCERP) Annual Technical Report IV: March 2010-February 2011

DTIC Science & Technology

2011-05-01

of monitoring may be necessary to fully characterize and model the impact of major climatic events (e.g., tropical cyclones, major droughts ) and...stressors (past, present, and future) at local and regional scales; take account of extreme climatic events (e.g., hurricanes, droughts ); and integrate...the longleaf pine ( Pinus palustris), savannas, and pocosins (shrub bog) that dominate MCBCL’s terrestrial environments. Variation in the biota and

Integration of Nanofluids into Commercial Antifreeze Concentrates with ASTM D15 Corrosion Testing

DTIC Science & Technology

2013-05-01

are also proprietary. Blending and Milling A Fisher Scientific Model 550 Sonic Disembrator was used in making nano dispersions. A horizontal 2L...Commercial Antifreeze Zerex/Water Three Zerex antifreeze concentrates were chosen: Zerex G-05: Phosphate free, long life hybrid formulation, mostly used ...for passenger cars. Zerex 618: Fully formulated with organic acid, mostly used for heavy duty diesel engines. Zerex Dex-Cool: Phosphate and silicate

Modeling Fanconi Anemia pathogenesis and therapeutics using integration-free patient-derived iPSCs

PubMed Central

Montserrat, Nuria; Tarantino, Carolina; Gu, Ying; Yi, Fei; Xu, Xiuling; Zhang, Weiqi; Ruiz, Sergio; Plongthongkum, Nongluk; Zhang, Kun; Masuda, Shigeo; Nivet, Emmanuel; Tsunekawa, Yuji; Soligalla, Rupa Devi; Goebl, April; Aizawa, Emi; Kim, Na Young; Kim, Jessica; Dubova, Ilir; Li, Ying; Ren, Ruotong; Benner, Chris; del Sol, Antonio; Bueren, Juan; Trujillo, Juan Pablo; Surralles, Jordi; Cappelli, Enrico; Dufour, Carlo; Esteban, Concepcion Rodriguez; Belmonte, Juan Carlos Izpisua

2014-01-01

Fanconi Anemia (FA) is a recessive disorder characterized by genomic instability, congenital abnormalities, cancer predisposition and bone marrow failure. However, the pathogenesis of FA is not fully understood partly due to the limitations of current disease models. Here, we derive integration-free induced pluripotent stem cells (iPSCs) from an FA patient without genetic complementation and report in situ gene correction in FA-iPSCs as well as the generation of isogenic FANCA deficient human embryonic stem cell (ESC) lines. FA cellular phenotypes are recapitulated in iPSCs/ESCs and their adult stem/progenitor cell derivatives. By using isogenic pathogenic mutation-free controls as well as cellular and genomic tools, our model serves to facilitate the discovery of novel disease features. We validate our model as a drug-screening platform by identifying several compounds that improve hematopoietic differentiation of FA-iPSCs. These compounds are also able to rescue the hematopoietic phenotype of FA-patient bone marrow cells. PMID:24999918

Modelling Fanconi anemia pathogenesis and therapeutics using integration-free patient-derived iPSCs.

PubMed

Liu, Guang-Hui; Suzuki, Keiichiro; Li, Mo; Qu, Jing; Montserrat, Nuria; Tarantino, Carolina; Gu, Ying; Yi, Fei; Xu, Xiuling; Zhang, Weiqi; Ruiz, Sergio; Plongthongkum, Nongluk; Zhang, Kun; Masuda, Shigeo; Nivet, Emmanuel; Tsunekawa, Yuji; Soligalla, Rupa Devi; Goebl, April; Aizawa, Emi; Kim, Na Young; Kim, Jessica; Dubova, Ilir; Li, Ying; Ren, Ruotong; Benner, Chris; Del Sol, Antonio; Bueren, Juan; Trujillo, Juan Pablo; Surralles, Jordi; Cappelli, Enrico; Dufour, Carlo; Esteban, Concepcion Rodriguez; Belmonte, Juan Carlos Izpisua

2014-07-07

Fanconi anaemia (FA) is a recessive disorder characterized by genomic instability, congenital abnormalities, cancer predisposition and bone marrow (BM) failure. However, the pathogenesis of FA is not fully understood partly due to the limitations of current disease models. Here, we derive integration free-induced pluripotent stem cells (iPSCs) from an FA patient without genetic complementation and report in situ gene correction in FA-iPSCs as well as the generation of isogenic FANCA-deficient human embryonic stem cell (ESC) lines. FA cellular phenotypes are recapitulated in iPSCs/ESCs and their adult stem/progenitor cell derivatives. By using isogenic pathogenic mutation-free controls as well as cellular and genomic tools, our model serves to facilitate the discovery of novel disease features. We validate our model as a drug-screening platform by identifying several compounds that improve hematopoietic differentiation of FA-iPSCs. These compounds are also able to rescue the hematopoietic phenotype of FA patient BM cells.

A design for integration.

PubMed

Fenna, D

1977-09-01

For nearly two decades, the development of computerized information systems has struggled for acceptable compromises between the unattainable "total system" and the unacceptable separate applications. Integration of related applications is essential if the computer is to be exploited fully, yet relative simplicity is necessary for systems to be implemented in a reasonable time-scale. This paper discusses a system being progressively developed from minimal beginnings but which, from the outset, had a highly flexible and fully integrated system basis. The system is for batch processing, but can accommodate on-line data input; it is similar in its approach to many transaction-processing real-time systems.

Coupling integrated assessment and earth system models: concepts and an application to land use change

NASA Astrophysics Data System (ADS)

O'Neill, B. C.; Lawrence, P.; Ren, X.

2016-12-01

Collaboration between the integrated assessment modeling (IAM) and earth system modeling (ESM) communities is increasing, driven by a growing interest in research questions that require analysis integrating both social and natural science components. This collaboration often takes the form of integrating their respective models. There are a number of approaches available to implement this integration, ranging from one-way linkages to full two-way coupling, as well as approaches that retain a single modeling framework but improve the representation of processes from the other framework. We discuss the pros and cons of these different approaches and the conditions under which a two-way coupling of IAMs and ESMs would be favored over a one-way linkage. We propose a criterion that is necessary and sufficient to motivate two-way coupling: A human process must have an effect on an earth system process that is large enough to cause a change in the original human process that is substantial compared to other uncertainties in the problem being investigated. We then illustrate a test of this criterion for land use-climate interactions based on work using the Community Earth System Model (CESM) and land use scenarios from the Representative Concentration Pathways (RCPs), in which we find that the land use effect on regional climate is unlikely to meet the criterion. We then show an example of implementing a one-way linkage of land use and agriculture between an IAM, the integrated Population-Economy-Technology-Science (iPETS) model, and CESM that produces fully consistent outcomes between iPETS and the CESM land surface model. We use the linked system to model the influence of climate change on crop yields, agricultural land use, crop prices and food consumption under two alternative future climate scenarios. This application demonstrates the ability to link an IAM to a global land surface and climate model in a computationally efficient manner.

Data driven modeling of plastic deformation

DOE PAGES

Versino, Daniele; Tonda, Alberto; Bronkhorst, Curt A.

2017-05-01

In this paper the application of machine learning techniques for the development of constitutive material models is being investigated. A flow stress model, for strain rates ranging from 10 –4 to 10 12 (quasi-static to highly dynamic), and temperatures ranging from room temperature to over 1000 K, is obtained by beginning directly with experimental stress-strain data for Copper. An incrementally objective and fully implicit time integration scheme is employed to integrate the hypo-elastic constitutive model, which is then implemented into a finite element code for evaluation. Accuracy and performance of the flow stress models derived from symbolic regression are assessedmore » by comparison to Taylor anvil impact data. The results obtained with the free-form constitutive material model are compared to well-established strength models such as the Preston-Tonks-Wallace (PTW) model and the Mechanical Threshold Stress (MTS) model. Here, preliminary results show candidate free-form models comparing well with data in regions of stress-strain space with sufficient experimental data, pointing to a potential means for both rapid prototyping in future model development, as well as the use of machine learning in capturing more data as a guide for more advanced model development.« less

Data driven modeling of plastic deformation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Versino, Daniele; Tonda, Alberto; Bronkhorst, Curt A.

In this paper the application of machine learning techniques for the development of constitutive material models is being investigated. A flow stress model, for strain rates ranging from 10 –4 to 10 12 (quasi-static to highly dynamic), and temperatures ranging from room temperature to over 1000 K, is obtained by beginning directly with experimental stress-strain data for Copper. An incrementally objective and fully implicit time integration scheme is employed to integrate the hypo-elastic constitutive model, which is then implemented into a finite element code for evaluation. Accuracy and performance of the flow stress models derived from symbolic regression are assessedmore » by comparison to Taylor anvil impact data. The results obtained with the free-form constitutive material model are compared to well-established strength models such as the Preston-Tonks-Wallace (PTW) model and the Mechanical Threshold Stress (MTS) model. Here, preliminary results show candidate free-form models comparing well with data in regions of stress-strain space with sufficient experimental data, pointing to a potential means for both rapid prototyping in future model development, as well as the use of machine learning in capturing more data as a guide for more advanced model development.« less

Foreign Police Development: The Third Time’s the Charm

DTIC Science & Technology

2010-02-10

inclusive concept of a standing Interagency Task Force ( IATF ) headquarters, which would deploy on short notice as part of a combatant command’s...COCOM) combined joint task force (CJTF). In this case, the President would appoint a senior civilian to lead the IATF and its fully integrated civil...agencies in support seems the most practical, flexible, and cost-effective. Part of that IATF would be a fully integrated police development team

An integral turbulent kinetic energy analysis of free shear flows

NASA Technical Reports Server (NTRS)

Peters, C. E.; Phares, W. J.

1973-01-01

Mixing of coaxial streams is analyzed by application of integral techniques. An integrated turbulent kinetic energy (TKE) equation is solved simultaneously with the integral equations for the mean flow. Normalized TKE profile shapes are obtained from incompressible jet and shear layer experiments and are assumed to be applicable to all free turbulent flows. The shear stress at the midpoint of the mixing zone is assumed to be directly proportional to the local TKE, and dissipation is treated with a generalization of the model developed for isotropic turbulence. Although the analysis was developed for ducted flows, constant-pressure flows were approximated with the duct much larger than the jet. The axisymmetric flows under consideration were predicted with reasonable accuracy. Fairly good results were also obtained for the fully developed two-dimensional shear layers, which were computed as thin layers at the boundary of a large circular jet.

Parameter redundancy in discrete state-space and integrated models.

PubMed

Cole, Diana J; McCrea, Rachel S

2016-09-01

Discrete state-space models are used in ecology to describe the dynamics of wild animal populations, with parameters, such as the probability of survival, being of ecological interest. For a particular parametrization of a model it is not always clear which parameters can be estimated. This inability to estimate all parameters is known as parameter redundancy or a model is described as nonidentifiable. In this paper we develop methods that can be used to detect parameter redundancy in discrete state-space models. An exhaustive summary is a combination of parameters that fully specify a model. To use general methods for detecting parameter redundancy a suitable exhaustive summary is required. This paper proposes two methods for the derivation of an exhaustive summary for discrete state-space models using discrete analogues of methods for continuous state-space models. We also demonstrate that combining multiple data sets, through the use of an integrated population model, may result in a model in which all parameters are estimable, even though models fitted to the separate data sets may be parameter redundant. © 2016 The Author. Biometrical Journal published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Blur Clarified: A review and Synthesis of Blur Discrimination

NASA Technical Reports Server (NTRS)

Watson, Andrew B.; Ahumada, Albert J.

2011-01-01

Blur is an important attribute of human spatial vision, and sensitivity to blur has been the subject of considerable experimental research and theoretical modeling. Often these models have invoked specialized concepts or mechanisms, such as intrinsic blur, multiple channels, or blur estimation units. In this paper we review the several experimental studies of blur discrimination and find they are in broad empirical agreement. But contrary to previous modeling efforts, we find that the essential features of blur discrimination are fully accounted for by a visible contrast energy model (ViCE), in which two spatial patterns are distinguished when the integrated difference between their masked local contrast energy responses reaches a threshold value.

Determining Pain Detection and Tolerance Thresholds Using an Integrated, Multi-Modal Pain Task Battery.

PubMed

Hay, Justin L; Okkerse, Pieter; van Amerongen, Guido; Groeneveld, Geert Jan

2016-04-14

Human pain models are useful in the assessing the analgesic effect of drugs, providing information about a drug's pharmacology and identify potentially suitable therapeutic populations. The need to use a comprehensive battery of pain models is highlighted by studies whereby only a single pain model, thought to relate to the clinical situation, demonstrates lack of efficacy. No single experimental model can mimic the complex nature of clinical pain. The integrated, multi-modal pain task battery presented here encompasses the electrical stimulation task, pressure stimulation task, cold pressor task, the UVB inflammatory model which includes a thermal task and a paradigm for inhibitory conditioned pain modulation. These human pain models have been tested for predicative validity and reliability both in their own right and in combination, and can be used repeatedly, quickly, in short succession, with minimum burden for the subject and with a modest quantity of equipment. This allows a drug to be fully characterized and profiled for analgesic effect which is especially useful for drugs with a novel or untested mechanism of action.

A low power on-chip class-E power amplifier for remotely powered implantable sensor systems

NASA Astrophysics Data System (ADS)

Ture, Kerim; Kilinc, Enver G.; Dehollain, Catherine

2015-06-01

This paper presents a low power fully integrated class-E power amplifier and its integration with remotely powered sensor system. The class-E power amplifier is suitable solution for low-power applications due to its high power efficiency. However, the required high inductance values which make the on-chip integration of the power amplifier difficult. The designed power amplifier is fully integrated in the remotely powered sensor system and fabricated in 0.18 μm CMOS process. The power is transferred to the implantable sensor system at 13.56 MHz by using an inductively coupled remote powering link. The induced AC voltage on the implant coil is converted into a DC voltage by a passive full-wave rectifier. A voltage regulator is used to suppress the ripples and create a clean and stable 1.8 V supply voltage for the sensor and communication blocks. The data collected from the sensors is transmitted by on-off keying modulated low-power transmitter at 1.2 GHz frequency. The transmitter is composed of a LC tank oscillator and a fully on-chip class-E power amplifier. An additional output network is used for the power amplifier which makes the integration of the power amplifier fully on-chip. The integrated power amplifier with 0.2 V supply voltage has a drain efficiency of 31.5% at -10 dBm output power for 50 Ω load. The measurement results verify the functionality of the power amplifier and the remotely powered implantable sensor system. The data communication is also verified by using a commercial 50 Ω chip antenna and has 600 kbps data rate at 1 m communication distance.

Widespread mechanosensing controls the structure behind the architecture in plants.

PubMed

Hamant, Olivier

2013-10-01

Mechanical forces play an instructing role for many aspects of animal cell biology, such as division, polarity and fate. Although the associated mechanoperception pathways still remain largely elusive in plants, physical cues have long been thought to guide development in parallel to biochemical factors. With the development of new imaging techniques, micromechanics tools and modeling approaches, the role of mechanical signals in plant development is now re-examined and fully integrated with modern cell biology. Using recent examples from the literature, I propose to use a multiscale perspective, from the whole plant down to the cell wall, to fully appreciate the diversity of developmental processes that depend on mechanical signals. Incidentally, this also illustrates how conceptually rich this field is. Copyright © 2013 Elsevier Ltd. All rights reserved.

A 10.6mm3 Fully-Integrated, Wireless Sensor Node with 8GHz UWB Transmitter.

PubMed

Kim, Hyeongseok; Kim, Gyouho; Lee, Yoonmyung; Foo, Zhiyoong; Sylvester, Dennis; Blaauw, David; Wentzloff, David

2015-06-01

This paper presents a complete, autonomous, wireless temperature sensor, fully encapsulated in a 10.6mm 3 volume. The sensor includes solar energy harvesting with an integrated 2 μAh battery, optical receiver for programming, microcontroller and memory, 8GHz UWB transmitter, and miniaturized custom antennas with a wireless range of 7 meters. Full, stand-alone operation was demonstrated for the first time for a system of this size and functionality.

Response of a partially penetrating well in a heterogeneous aquifer: integrated well-face flux vs. uniform well-face flux boundary conditions

NASA Astrophysics Data System (ADS)

Ruud, N. C.; Kabala, Z. J.

1997-07-01

A two-dimensional integrated well-face flux (IWFF) model is developed for computing the drawdown at the well-face and around a fully or partially penetrating well with wellbore storage, situated in a layered confined aquifer. In this model, we calculate drawdown and well-face flux distributions by numerically solving a two-dimensional diffusion equation in cylindrical coordinates subject to appropriate initial and boundary conditions and to the well-face boundary constraint of an integrated well-face flux rather than the physically inconsistent uniform well-face flux boundary condition (the UWFF model). The differences between the IWFF and UWFF models in a partially penetrating well situated in a homogeneous isotropic aquifer are insignificant for wellbore drawdown (less than 3%) but are pronounced for the well-face flux. In fact, the latter strongly deviates from uniformity as the ratio of the screen length to the aquifer thickness decreases. For partially penetrating wells situated in multilayer aquifers, significant differences between the two models may arise, especially if the screen is not located in the most conductive layer. These differences depend on the hydraulic conductivity contrast of the adjacent layers. Consequently, the uniform well-face flux boundary condition should be used with extreme caution.

Incorporating the soil environment and microbial community into plant competition theory

PubMed Central

Ke, Po-Ju; Miki, Takeshi

2015-01-01

Plants affect microbial communities and abiotic properties of nearby soils, which in turn influence plant growth and interspecific interaction, forming a plant-soil feedback (PSF). PSF is a key determinant influencing plant population dynamics, community structure, and ecosystem functions. Despite accumulating evidence for the importance of PSF and development of specific PSF models, different models are not yet fully integrated. Here, we review the theoretical progress in understanding PSF. When first proposed, PSF was integrated with various mathematical frameworks to discuss its influence on plant competition. Recent theoretical models have advanced PSF research at different levels of ecological organizations by considering multiple species, applying spatially explicit simulations to examine how local-scale predictions apply to larger scales, and assessing the effect of PSF on plant temporal dynamics over the course of succession. We then review two foundational models for microbial- and litter-mediated PSF. We present a theoretical framework to illustrate that although the two models are typically presented separately, their behavior can be understood together by invasibility analysis. We conclude with suggestions for future directions in PSF theoretical studies, which include specifically addressing microbial diversity to integrate litter- and microbial-mediated PSF, and apply PSF to general coexistence theory through a trait-based approach. PMID:26500621

Heterogeneous Silicon III-V Mode-Locked Lasers

NASA Astrophysics Data System (ADS)

Davenport, Michael Loehrlein

Mode-locked lasers are useful for a variety of applications, such as sensing, telecommunication, and surgical instruments. This work focuses on integrated-circuit mode-locked lasers: those that combine multiple optical and electronic functions and are manufactured together on a single chip. While this allows production at high volume and lower cost, the true potential of integration is to open applications for mode-locked laser diodes where solid state lasers cannot fit, either due to size and power consumption constraints, or where small optical or electrical paths are needed for high bandwidth. Unfortunately, most high power and highly stable mode-locked laser diode demonstrations in scientific literature are based on the Fabry-Perot resonator design, with cleaved mirrors, and are unsuitable for use in integrated circuits because of the difficulty of producing integrated Fabry-Perot cavities. We use silicon photonics and heterogeneous integration with III-V gain material to produce the most powerful and lowest noise fully integrated mode-locked laser diode in the 20 GHz frequency range. If low noise and high peak power are required, it is arguably the best performing fully integrated mode-locked laser ever demonstrated. We present the design methodology and experimental pathway to realize a fully integrated mode-locked laser diode. The construction of the device, beginning with the selection of an integration platform, and proceeding through the fabrication process to final optimization, is presented in detail. The dependence of mode-locked laser performance on a wide variety of design parameters is presented. Applications for integrated circuit mode-locked lasers are also discussed, as well as proposed methods for using integration to improve mode-locking performance to beyond the current state of the art.

Tidal Love Numbers of Neutron Stars

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hinderer, Tanja

For a variety of fully relativistic polytropic neutron star models we calculate the star's tidal Love number k{sub 2}. Most realistic equations of state for neutron stars can be approximated as a polytrope with an effective index n {approx} 0.5-1.0. The equilibrium stellar model is obtained by numerical integration of the Tolman-Oppenheimer-Volkhov equations. We calculate the linear l = 2 static perturbations to the Schwarzschild spacetime following the method of Thorne and Campolattaro. Combining the perturbed Einstein equations into a single second-order differential equation for the perturbation to the metric coefficient g{sub tt} and matching the exterior solution to themore » asymptotic expansion of the metric in the star's local asymptotic rest frame gives the Love number. Our results agree well with the Newtonian results in the weak field limit. The fully relativistic values differ from the Newtonian values by up to {approx}24%. The Love number is potentially measurable in gravitational wave signals from inspiralling binary neutron stars.« less

Towards full-Braginskii implicit extended MHD

NASA Astrophysics Data System (ADS)

Chacon, Luis

2009-05-01

Recently, viable algorithms have been proposed for the scalable, fully-implicit temporal integration of 3D resistive MHD and cold-ion extended MHD models. While significant, these achievements must be tempered by the fact that such models lack predictive capabilities in regimes of interest for magnetic fusion. Short of including kinetic closures, a natural evolution path towards predictability starts by considering additional terms as described in Braginskii's fluid closures in the collisional regime. Here, we focus on the inclusion of two fundamental elements of relevance for fusion plasmas: anisotropic parallel electron transport, and warm-ion physics (i.e., ion finite Larmor radius effects, included via gyroviscosity). Both these elements introduce significant numerical difficulties, due to the strong anisotropy in the former, and the presence of dispersive waves in the latter. In this presentation, we will discuss progress in our fully implicit algorithmic formulation towards the inclusion of both these elements. L. Chac'on, Phys. Plasmas, 15, 056103 (2008) L. Chac'on, J. Physics: Conf. Series, 125, 012041 (2008)

Blood Glucose Meters and Accessibility to Blind and Visually Impaired People

PubMed Central

Burton, Darren M.; Enigk, Matthew G.; Lilly, John W.

2012-01-01

In 2007, five blood glucose meters (BGMs) were introduced with integrated speech output necessary for use by persons with vision loss. One of those five meters had fully integrated speech output, allowing a person with vision loss independence in accessing all features and functions of the meter. In comparison, 13 BGMs with integrated speech output were available in 2011. Accessibility attributes of these 11 meters were tabulated and product design features examined. All 13 meters were found to be usable by persons with vision loss to obtain a blood glucose measurement. However, only 4 of them featured the fully integrated speech output necessary for a person with vision loss to access all features and functions independently. PMID:22538131

A fully-integrated 12.5-Gb/s 850-nm CMOS optical receiver based on a spatially-modulated avalanche photodetector.

PubMed

Lee, Myung-Jae; Youn, Jin-Sung; Park, Kang-Yeob; Choi, Woo-Young

2014-02-10

We present a fully integrated 12.5-Gb/s optical receiver fabricated with standard 0.13-µm complementary metal-oxide-semiconductor (CMOS) technology for 850-nm optical interconnect applications. Our integrated optical receiver includes a newly proposed CMOS-compatible spatially-modulated avalanche photodetector, which provides larger photodetection bandwidth than previously reported CMOS-compatible photodetectors. The receiver also has high-speed CMOS circuits including transimpedance amplifier, DC-balanced buffer, equalizer, and limiting amplifier. With the fabricated optical receiver, detection of 12.5-Gb/s optical data is successfully achieved at 5.8 pJ/bit. Our receiver achieves the highest data rate ever reported for 850-nm integrated CMOS optical receivers.

Blood glucose meters and accessibility to blind and visually impaired people.

PubMed

Burton, Darren M; Enigk, Matthew G; Lilly, John W

2012-03-01

In 2007, five blood glucose meters (BGMs) were introduced with integrated speech output necessary for use by persons with vision loss. One of those five meters had fully integrated speech output, allowing a person with vision loss independence in accessing all features and functions of the meter. In comparison, 13 BGMs with integrated speech output were available in 2011. Accessibility attributes of these 11 meters were tabulated and product design features examined. All 13 meters were found to be usable by persons with vision loss to obtain a blood glucose measurement. However, only 4 of them featured the fully integrated speech output necessary for a person with vision loss to access all features and functions independently. © 2012 Diabetes Technology Society.

Modeling the hydro-mechanical responses of strip and circular punch loadings on water-saturated collapsible geomaterials

DOE PAGES

Sun, WaiChing; Chen, Qiushi; Ostien, Jakob T.

2013-11-22

A stabilized enhanced strain finite element procedure for poromechanics is fully integrated with an elasto-plastic cap model to simulate the hydro-mechanical interactions of fluid-infiltrating porous rocks with associative and non-associative plastic flow. We present a quantitative analysis on how macroscopic plastic volumetric response caused by pore collapse and grain rearrangement affects the seepage of pore fluid, and vice versa. Results of finite element simulations imply that the dissipation of excess pore pressure may significantly affect the stress path and thus alter the volumetric plastic responses.

Jupiter Environment Tool

NASA Technical Reports Server (NTRS)

Sturm, Erick J.; Monahue, Kenneth M.; Biehl, James P.; Kokorowski, Michael; Ngalande, Cedrick,; Boedeker, Jordan

2012-01-01

The Jupiter Environment Tool (JET) is a custom UI plug-in for STK that provides an interface to Jupiter environment models for visualization and analysis. Users can visualize the different magnetic field models of Jupiter through various rendering methods, which are fully integrated within STK s 3D Window. This allows users to take snapshots and make animations of their scenarios with magnetic field visualizations. Analytical data can be accessed in the form of custom vectors. Given these custom vectors, users have access to magnetic field data in custom reports, graphs, access constraints, coverage analysis, and anywhere else vectors are used within STK.

Development and validation of P-MODTRAN7 and P-MCScene, 1D and 3D polarimetric radiative transfer models

NASA Astrophysics Data System (ADS)

Hawes, Frederick T.; Berk, Alexander; Richtsmeier, Steven C.

2016-05-01

A validated, polarimetric 3-dimensional simulation capability, P-MCScene, is being developed by generalizing Spectral Sciences' Monte Carlo-based synthetic scene simulation model, MCScene, to include calculation of all 4 Stokes components. P-MCScene polarimetric optical databases will be generated by a new version (MODTRAN7) of the government-standard MODTRAN radiative transfer algorithm. The conversion of MODTRAN6 to a polarimetric model is being accomplished by (1) introducing polarimetric data, by (2) vectorizing the MODTRAN radiation calculations and by (3) integrating the newly revised and validated vector discrete ordinate model VDISORT3. Early results, presented here, demonstrate a clear pathway to the long-term goal of fully validated polarimetric models.

Phase field modeling of brittle fracture for enhanced assumed strain shells at large deformations: formulation and finite element implementation

NASA Astrophysics Data System (ADS)

Reinoso, J.; Paggi, M.; Linder, C.

2017-06-01

Fracture of technological thin-walled components can notably limit the performance of their corresponding engineering systems. With the aim of achieving reliable fracture predictions of thin structures, this work presents a new phase field model of brittle fracture for large deformation analysis of shells relying on a mixed enhanced assumed strain (EAS) formulation. The kinematic description of the shell body is constructed according to the solid shell concept. This enables the use of fully three-dimensional constitutive models for the material. The proposed phase field formulation integrates the use of the (EAS) method to alleviate locking pathologies, especially Poisson thickness and volumetric locking. This technique is further combined with the assumed natural strain method to efficiently derive a locking-free solid shell element. On the computational side, a fully coupled monolithic framework is consistently formulated. Specific details regarding the corresponding finite element formulation and the main aspects associated with its implementation in the general purpose packages FEAP and ABAQUS are addressed. Finally, the applicability of the current strategy is demonstrated through several numerical examples involving different loading conditions, and including linear and nonlinear hyperelastic constitutive models.

Supporting Collaborative Model and Data Service Development and Deployment with DevOps

NASA Astrophysics Data System (ADS)

David, O.

2016-12-01

Adopting DevOps practices for model service development and deployment enables a community to engage in service-oriented modeling and data management. The Cloud Services Integration Platform (CSIP) developed the last 5 years at Colorado State University provides for collaborative integration of environmental models into scalable model and data services as a micro-services platform with API and deployment infrastructure. Originally developed to support USDA natural resource applications, it proved suitable for a wider range of applications in the environmental modeling domain. While extending its scope and visibility it became apparent community integration and adequate work flow support through the full model development and application cycle drove successful outcomes.DevOps provide best practices, tools, and organizational structures to optimize the transition from model service development to deployment by minimizing the (i) operational burden and (ii) turnaround time for modelers. We have developed and implemented a methodology to fully automate a suite of applications for application lifecycle management, version control, continuous integration, container management, and container scaling to enable model and data service developers in various institutions to collaboratively build, run, deploy, test, and scale services within minutes.To date more than 160 model and data services are available for applications in hydrology (PRMS, Hydrotools, CFA, ESP), water and wind erosion prediction (WEPP, WEPS, RUSLE2), soil quality trends (SCI, STIR), water quality analysis (SWAT-CP, WQM, CFA, AgES-W), stream degradation assessment (SWAT-DEG), hydraulics (cross-section), and grazing management (GRAS). In addition, supporting data services include soil (SSURGO), ecological site (ESIS), climate (CLIGEN, WINDGEN), land management and crop rotations (LMOD), and pesticides (WQM), developed using this workflow automation and decentralized governance.

Enviro-HIRLAM online integrated meteorology-chemistry modelling system: strategy, methodology, developments and applications (v7.2)

NASA Astrophysics Data System (ADS)

Baklanov, Alexander; Smith Korsholm, Ulrik; Nuterman, Roman; Mahura, Alexander; Pagh Nielsen, Kristian; Hansen Sass, Bent; Rasmussen, Alix; Zakey, Ashraf; Kaas, Eigil; Kurganskiy, Alexander; Sørensen, Brian; González-Aparicio, Iratxe

2017-08-01

The Environment - High Resolution Limited Area Model (Enviro-HIRLAM) is developed as a fully online integrated numerical weather prediction (NWP) and atmospheric chemical transport (ACT) model for research and forecasting of joint meteorological, chemical and biological weather. The integrated modelling system is developed by the Danish Meteorological Institute (DMI) in collaboration with several European universities. It is the baseline system in the HIRLAM Chemical Branch and used in several countries and different applications. The development was initiated at DMI more than 15 years ago. The model is based on the HIRLAM NWP model with online integrated pollutant transport and dispersion, chemistry, aerosol dynamics, deposition and atmospheric composition feedbacks. To make the model suitable for chemical weather forecasting in urban areas, the meteorological part was improved by implementation of urban parameterisations. The dynamical core was improved by implementing a locally mass-conserving semi-Lagrangian numerical advection scheme, which improves forecast accuracy and model performance. The current version (7.2), in comparison with previous versions, has a more advanced and cost-efficient chemistry, aerosol multi-compound approach, aerosol feedbacks (direct and semi-direct) on radiation and (first and second indirect effects) on cloud microphysics. Since 2004, the Enviro-HIRLAM has been used for different studies, including operational pollen forecasting for Denmark since 2009 and operational forecasting atmospheric composition with downscaling for China since 2017. Following the main research and development strategy, further model developments will be extended towards the new NWP platform - HARMONIE. Different aspects of online coupling methodology, research strategy and possible applications of the modelling system, and fit-for-purpose model configurations for the meteorological and air quality communities are discussed.

Cost analysis of hospital material management systems.

PubMed

Egbelu, P J; Harmonosky, C M; Ventura, J A; O'Brien, W E; Sommer, H J

1998-01-01

Integrated healthcare material management begins with manufactures of medical/surgical supplies, uses distributors and ends at the point of use at hospitals. Recent material management philosophies in the healthcare industry, such as just-in-time and stockless systems, are yet to be fully evaluated. In order to evaluate the cost effectiveness of each type of material management technique, a cost model for hospital materials management has been designed. Several case scenarios are analyzed and results are reported.

Photonic integrated circuits unveil crisis-induced intermittency.

PubMed

Karsaklian Dal Bosco, Andreas; Akizawa, Yasuhiro; Kanno, Kazutaka; Uchida, Atsushi; Harayama, Takahisa; Yoshimura, Kazuyuki

2016-09-19

We experimentally investigate an intermittent route to chaos in a photonic integrated circuit consisting of a semiconductor laser with time-delayed optical feedback from a short external cavity. The transition from a period-doubling dynamics to a fully-developed chaos reveals a stage intermittently exhibiting these two dynamics. We unveil the bifurcation mechanism underlying this route to chaos by using the Lang-Kobayashi model and demonstrate that the process is based on a phenomenon of attractor expansion initiated by a particular distribution of the local Lyapunov exponents. We emphasize on the crucial importance of the distribution of the steady-state solutions introduced by the time-delayed feedback on the existence of this intermittent dynamics.

A review of recent advances in data analytics for post-operative patient deterioration detection.

PubMed

Petit, Clemence; Bezemer, Rick; Atallah, Louis

2018-06-01

Most deaths occurring due to a surgical intervention happen postoperatively rather than during surgery. The current standard of care in many hospitals cannot fully cope with detecting and addressing post-surgical deterioration in time. For millions of patients, this deterioration is left unnoticed, leading to increased mortality and morbidity. Postoperative deterioration detection currently relies on general scores that are not fully able to cater for the complex post-operative physiology of surgical patients. In the last decade however, advanced risk and warning scoring techniques have started to show encouraging results in terms of using the large amount of data available peri-operatively to improve postoperative deterioration detection. Relevant literature has been carefully surveyed to provide a summary of the most promising approaches as well as how they have been deployed in the perioperative domain. This work also aims to highlight the opportunities that lie in personalizing the models developed for patient deterioration for these particular post-surgical patients and make the output more actionable. The integration of pre- and intra-operative data, e.g. comorbidities, vitals, lab data, and information about the procedure performed, in post-operative early warning algorithms would lead to more contextualized, personalized, and adaptive patient modelling. This, combined with careful integration in the clinical workflow, would result in improved clinical decision support and better post-surgical care outcomes.

Stratification established by peeling detrainment from gravity currents: laboratory experiments and models

NASA Astrophysics Data System (ADS)

Hogg, Charlie; Dalziel, Stuart; Huppert, Herbert; Imberger, Jorg; Department of Applied Mathematics; Theoretical Physics Team; CentreWater Research Team

2014-11-01

Dense gravity currents feed fluid into confined basins in lakes, the oceans and many industrial applications. Existing models of the circulation and mixing in such basins are often based on the currents entraining ambient fluid. However, recent observations have suggested that uni-directional entrainment into a gravity current does not fully describe the mixing in such currents. Laboratory experiments were carried out which visualised peeling detrainment from the gravity current occurring when the ambient fluid was stratified. A theoretical model of the observed peeling detrainment was developed to predict the stratification in the basin. This new model gives a better approximation of the stratification observed in the experiments than the pre-existing entraining model. The model can now be developed such that it integrates into operational models of lakes.

The Shale Hills Critical Zone Observatory for Embedded Sensing and Simulation

NASA Astrophysics Data System (ADS)

Duffy, C.; Davis, K.; Kane, T.; Boyer, E.

2009-04-01

The future of environmental observing systems will utilize embedded sensor networks with continuous real-time measurement of hydrologic, atmospheric, biogeochemical, and ecological variables across diverse terrestrial environments. Embedded environmental sensors, benefitting from advances in information sciences, networking technology, materials science, computing capacity, and data synthesis methods, are undergoing revolutionary change. It is now possible to field spatially-distributed, multi-node sensor networks that provide density and spatial coverage previously accessible only via numerical simulation. At the same time, computational tools are advancing rapidly to the point where it is now possible to simulate the physical processes controlling individual parcels of water and solutes through the complete terrestrial water cycle. Our goal for the Penn State Critical Zone Observatory is to apply environmental sensor arrays, integrated hydrologic models deployed and coordinated at a testbed within the Penn State Experimental Forest. The NSF-funded CZO is designed to observe the detailed space and time complexities of the water and energy cycle for a watershed and ultimately the river basin for all physical states and fluxes (groundwater, soil moisture, temperature, streamflow, latent heat, snowmelt, chemistry, isotopes etc.). Presently fully-coupled physical models are being developed that link the atmosphere-land-vegetation-subsurface system into a fully-coupled distributed system. During the last 5 years the Penn State Integrated Hydrologic Modeling System has been under development as an open-source community modeling project funded by NSF EAR/GEO and NSF CBET/ENG. PIHM represents a strategy for the formulation and solution of fully-coupled process equations at the watershed and river basin scales, and includes a tightly coupled GIS tool for data handling, domain decomposition, optimal unstructured grid generation, and model parameterization. (PIHM; http://sourceforge.net/projects/pihmmodel/; http://sourceforge.net/projects/pihmgis/ ) The CZO sensor and simulation system is being developed to have the following elements: 1) extensive, spatially-distributed smart sensor networks to gather intensive soil, geologic, hydrologic, geochemical and isotopic data; 2) spatially-explicit multiphysics models/solutions of the land-subsurface-vegetation-atmosphere system; and 3) parallel/distributed, adaptive algorithms for rapidly simulating the states of the watershed at high resolution, and 4) signal processing tools for data mining and parameter estimation. The prototype proposed sensor array and simulation system proposed is demonstrated with preliminary results from our first year.

Numerical study of hydrogen-air supersonic combustion by using elliptic and parabolized equations

NASA Technical Reports Server (NTRS)

Chitsomboon, T.; Tiwari, S. N.

1986-01-01

The two-dimensional Navier-Stokes and species continuity equations are used to investigate supersonic chemically reacting flow problems which are related to scramjet-engine configurations. A global two-step finite-rate chemistry model is employed to represent the hydrogen-air combustion in the flow. An algebraic turbulent model is adopted for turbulent flow calculations. The explicit unsplit MacCormack finite-difference algorithm is used to develop a computer program suitable for a vector processing computer. The computer program developed is then used to integrate the system of the governing equations in time until convergence is attained. The chemistry source terms in the species continuity equations are evaluated implicitly to alleviate stiffness associated with fast chemical reactions. The problems solved by the elliptic code are re-investigated by using a set of two-dimensional parabolized Navier-Stokes and species equations. A linearized fully-coupled fully-implicit finite difference algorithm is used to develop a second computer code which solves the governing equations by marching in spce rather than time, resulting in a considerable saving in computer resources. Results obtained by using the parabolized formulation are compared with the results obtained by using the fully-elliptic equations. The comparisons indicate fairly good agreement of the results of the two formulations.

Performance of a parallel algebraic multilevel preconditioner for stabilized finite element semiconductor device modeling

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lin, Paul T.; Shadid, John N.; Sala, Marzio

In this study results are presented for the large-scale parallel performance of an algebraic multilevel preconditioner for solution of the drift-diffusion model for semiconductor devices. The preconditioner is the key numerical procedure determining the robustness, efficiency and scalability of the fully-coupled Newton-Krylov based, nonlinear solution method that is employed for this system of equations. The coupled system is comprised of a source term dominated Poisson equation for the electric potential, and two convection-diffusion-reaction type equations for the electron and hole concentration. The governing PDEs are discretized in space by a stabilized finite element method. Solution of the discrete system ismore » obtained through a fully-implicit time integrator, a fully-coupled Newton-based nonlinear solver, and a restarted GMRES Krylov linear system solver. The algebraic multilevel preconditioner is based on an aggressive coarsening graph partitioning of the nonzero block structure of the Jacobian matrix. Representative performance results are presented for various choices of multigrid V-cycles and W-cycles and parameter variations for smoothers based on incomplete factorizations. Parallel scalability results are presented for solution of up to 10{sup 8} unknowns on 4096 processors of a Cray XT3/4 and an IBM POWER eServer system.« less

Insights in time dependent cross compartment sensitivities from ensemble simulations with the fully coupled subsurface-land surface-atmosphere model TerrSysMP

NASA Astrophysics Data System (ADS)

Schalge, Bernd; Rihani, Jehan; Haese, Barbara; Baroni, Gabriele; Erdal, Daniel; Haefliger, Vincent; Lange, Natascha; Neuweiler, Insa; Hendricks-Franssen, Harrie-Jan; Geppert, Gernot; Ament, Felix; Kollet, Stefan; Cirpka, Olaf; Saavedra, Pablo; Han, Xujun; Attinger, Sabine; Kunstmann, Harald; Vereecken, Harry; Simmer, Clemens

2017-04-01

Currently, an integrated approach to simulating the earth system is evolving where several compartment models are coupled to achieve the best possible physically consistent representation. We used the model TerrSysMP, which fully couples subsurface, land surface and atmosphere, in a synthetic study that mimicked the Neckar catchment in Southern Germany. A virtual reality run at a high resolution of 400m for the land surface and subsurface and 1.1km for the atmosphere was made. Ensemble runs at a lower resolution (800m for the land surface and subsurface) were also made. The ensemble was generated by varying soil and vegetation parameters and lateral atmospheric forcing among the different ensemble members in a systematic way. It was found that the ensemble runs deviated for some variables and some time periods largely from the virtual reality reference run (the reference run was not covered by the ensemble), which could be related to the different model resolutions. This was for example the case for river discharge in the summer. We also analyzed the spread of model states as function of time and found clear relations between the spread and the time of the year and weather conditions. For example, the ensemble spread of latent heat flux related to uncertain soil parameters was larger under dry soil conditions than under wet soil conditions. Another example is that the ensemble spread of atmospheric states was more influenced by uncertain soil and vegetation parameters under conditions of low air pressure gradients (in summer) than under conditions with larger air pressure gradients in winter. The analysis of the ensemble of fully coupled model simulations provided valuable insights in the dynamics of land-atmosphere feedbacks which we will further highlight in the presentation.

Response of the Antarctic ice sheet to ocean forcing using the POPSICLES coupled ice sheet-ocean model

NASA Astrophysics Data System (ADS)

Martin, D. F.; Asay-Davis, X.; Price, S. F.; Cornford, S. L.; Maltrud, M. E.; Ng, E. G.; Collins, W.

2014-12-01

We present the response of the continental Antarctic ice sheet to sub-shelf-melt forcing derived from POPSICLES simulation results covering the full Antarctic Ice Sheet and the Southern Ocean spanning the period 1990 to 2010. Simulations are performed at 0.1 degree (~5 km) ocean resolution and ice sheet resolution as fine as 500 m using adaptive mesh refinement. A comparison of fully-coupled and comparable standalone ice-sheet model results demonstrates the importance of two-way coupling between the ice sheet and the ocean. The POPSICLES model couples the POP2x ocean model, a modified version of the Parallel Ocean Program (Smith and Gent, 2002), and the BISICLES ice-sheet model (Cornford et al., 2012). BISICLES makes use of adaptive mesh refinement to fully resolve dynamically-important regions like grounding lines and employs a momentum balance similar to the vertically-integrated formulation of Schoof and Hindmarsh (2009). Results of BISICLES simulations have compared favorably to comparable simulations with a Stokes momentum balance in both idealized tests like MISMIP3D (Pattyn et al., 2013) and realistic configurations (Favier et al. 2014). POP2x includes sub-ice-shelf circulation using partial top cells (Losch, 2008) and boundary layer physics following Holland and Jenkins (1999), Jenkins (2001), and Jenkins et al. (2010). Standalone POP2x output compares well with standard ice-ocean test cases (e.g., ISOMIP; Losch, 2008) and other continental-scale simulations and melt-rate observations (Kimura et al., 2013; Rignot et al., 2013). A companion presentation, "Present-day circum-Antarctic simulations using the POPSICLES coupled land ice-ocean model" in session C027 describes the ocean-model perspective of this work, while we focus on the response of the ice sheet and on details of the model. The figure shows the BISICLES-computed vertically-integrated ice velocity field about 1 month into a 20-year coupled Antarctic run. Groundling lines are shown in green.

Quasi-brittle damage modeling based on incremental energy relaxation combined with a viscous-type regularization

NASA Astrophysics Data System (ADS)

Langenfeld, K.; Junker, P.; Mosler, J.

2018-05-01

This paper deals with a constitutive model suitable for the analysis of quasi-brittle damage in structures. The model is based on incremental energy relaxation combined with a viscous-type regularization. A similar approach—which also represents the inspiration for the improved model presented in this paper—was recently proposed in Junker et al. (Contin Mech Thermodyn 29(1):291-310, 2017). Within this work, the model introduced in Junker et al. (2017) is critically analyzed first. This analysis leads to an improved model which shows the same features as that in Junker et al. (2017), but which (i) eliminates unnecessary model parameters, (ii) can be better interpreted from a physics point of view, (iii) can capture a fully softened state (zero stresses), and (iv) is characterized by a very simple evolution equation. In contrast to the cited work, this evolution equation is (v) integrated fully implicitly and (vi) the resulting time-discrete evolution equation can be solved analytically providing a numerically efficient closed-form solution. It is shown that the final model is indeed well-posed (i.e., its tangent is positive definite). Explicit conditions guaranteeing this well-posedness are derived. Furthermore, by additively decomposing the stress rate into deformation- and purely time-dependent terms, the functionality of the model is explained. Illustrative numerical examples confirm the theoretical findings.

Independent Peer Review of Communications, Navigation, and Networking re-Configurable Testbed (CoNNeCT) Project Antenna Pointing Subsystem (APS) Integrated Gimbal Assembly (IGA) Structural Analysis

NASA Technical Reports Server (NTRS)

Raju, Ivatury S.; Larsen, Curtis E.; Pellicciotti, Joseph W.

2010-01-01

Glenn Research Center Chief Engineer's Office requested an independent review of the structural analysis and modeling of the Communications, Navigation, and Networking re-Configurable Testbed (CoNNeCT) Project Antenna Pointing Subsystem (APS) Integrated Gimbal Assembly (IGA) to be conducted by the NASA Engineering and Safety Center (NESC). At this time, the IGA had completed its critical design review (CDR). The assessment was to be a peer review of the NEi-NASTRAN1 model of the APS Antenna, and not a peer review of the design and the analysis that had been completed by the GRC team for CDR. Thus, only a limited amount of information was provided on the structural analysis. However, the NESC team had difficulty separating analysis concerns from modeling issues. The team studied the NASTRAN model, but did not fully investigate how the model was used by the CoNNeCT Project and how the Project was interpreting the results. The team's findings, observations, and NESC recommendations are contained in this report.

Stabilized FE simulation of prototype thermal-hydraulics problems with integrated adjoint-based capabilities

NASA Astrophysics Data System (ADS)

Shadid, J. N.; Smith, T. M.; Cyr, E. C.; Wildey, T. M.; Pawlowski, R. P.

2016-09-01

A critical aspect of applying modern computational solution methods to complex multiphysics systems of relevance to nuclear reactor modeling, is the assessment of the predictive capability of specific proposed mathematical models. In this respect the understanding of numerical error, the sensitivity of the solution to parameters associated with input data, boundary condition uncertainty, and mathematical models is critical. Additionally, the ability to evaluate and or approximate the model efficiently, to allow development of a reasonable level of statistical diagnostics of the mathematical model and the physical system, is of central importance. In this study we report on initial efforts to apply integrated adjoint-based computational analysis and automatic differentiation tools to begin to address these issues. The study is carried out in the context of a Reynolds averaged Navier-Stokes approximation to turbulent fluid flow and heat transfer using a particular spatial discretization based on implicit fully-coupled stabilized FE methods. Initial results are presented that show the promise of these computational techniques in the context of nuclear reactor relevant prototype thermal-hydraulics problems.

Stabilized FE simulation of prototype thermal-hydraulics problems with integrated adjoint-based capabilities

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shadid, J.N., E-mail: jnshadi@sandia.gov; Department of Mathematics and Statistics, University of New Mexico; Smith, T.M.

A critical aspect of applying modern computational solution methods to complex multiphysics systems of relevance to nuclear reactor modeling, is the assessment of the predictive capability of specific proposed mathematical models. In this respect the understanding of numerical error, the sensitivity of the solution to parameters associated with input data, boundary condition uncertainty, and mathematical models is critical. Additionally, the ability to evaluate and or approximate the model efficiently, to allow development of a reasonable level of statistical diagnostics of the mathematical model and the physical system, is of central importance. In this study we report on initial efforts tomore » apply integrated adjoint-based computational analysis and automatic differentiation tools to begin to address these issues. The study is carried out in the context of a Reynolds averaged Navier–Stokes approximation to turbulent fluid flow and heat transfer using a particular spatial discretization based on implicit fully-coupled stabilized FE methods. Initial results are presented that show the promise of these computational techniques in the context of nuclear reactor relevant prototype thermal-hydraulics problems.« less

Stabilized FE simulation of prototype thermal-hydraulics problems with integrated adjoint-based capabilities

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shadid, J. N.; Smith, T. M.; Cyr, E. C.

A critical aspect of applying modern computational solution methods to complex multiphysics systems of relevance to nuclear reactor modeling, is the assessment of the predictive capability of specific proposed mathematical models. The understanding of numerical error, the sensitivity of the solution to parameters associated with input data, boundary condition uncertainty, and mathematical models is critical. Additionally, the ability to evaluate and or approximate the model efficiently, to allow development of a reasonable level of statistical diagnostics of the mathematical model and the physical system, is of central importance. In our study we report on initial efforts to apply integrated adjoint-basedmore » computational analysis and automatic differentiation tools to begin to address these issues. The study is carried out in the context of a Reynolds averaged Navier–Stokes approximation to turbulent fluid flow and heat transfer using a particular spatial discretization based on implicit fully-coupled stabilized FE methods. We present the initial results that show the promise of these computational techniques in the context of nuclear reactor relevant prototype thermal-hydraulics problems.« less

Stabilized FE simulation of prototype thermal-hydraulics problems with integrated adjoint-based capabilities

DOE PAGES

Shadid, J. N.; Smith, T. M.; Cyr, E. C.; ...

2016-05-20

A critical aspect of applying modern computational solution methods to complex multiphysics systems of relevance to nuclear reactor modeling, is the assessment of the predictive capability of specific proposed mathematical models. The understanding of numerical error, the sensitivity of the solution to parameters associated with input data, boundary condition uncertainty, and mathematical models is critical. Additionally, the ability to evaluate and or approximate the model efficiently, to allow development of a reasonable level of statistical diagnostics of the mathematical model and the physical system, is of central importance. In our study we report on initial efforts to apply integrated adjoint-basedmore » computational analysis and automatic differentiation tools to begin to address these issues. The study is carried out in the context of a Reynolds averaged Navier–Stokes approximation to turbulent fluid flow and heat transfer using a particular spatial discretization based on implicit fully-coupled stabilized FE methods. We present the initial results that show the promise of these computational techniques in the context of nuclear reactor relevant prototype thermal-hydraulics problems.« less

The integrated Earth system model version 1: formulation and functionality

DOE PAGES

Collins, W. D.; Craig, A. P.; Truesdale, J. E.; ...

2015-07-23

The integrated Earth system model (iESM) has been developed as a new tool for projecting the joint human/climate system. The iESM is based upon coupling an integrated assessment model (IAM) and an Earth system model (ESM) into a common modeling infrastructure. IAMs are the primary tool for describing the human–Earth system, including the sources of global greenhouse gases (GHGs) and short-lived species (SLS), land use and land cover change (LULCC), and other resource-related drivers of anthropogenic climate change. ESMs are the primary scientific tools for examining the physical, chemical, and biogeochemical impacts of human-induced changes to the climate system. Themore » iESM project integrates the economic and human-dimension modeling of an IAM and a fully coupled ESM within a single simulation system while maintaining the separability of each model if needed. Both IAM and ESM codes are developed and used by large communities and have been extensively applied in recent national and international climate assessments. By introducing heretofore-omitted feedbacks between natural and societal drivers, we can improve scientific understanding of the human–Earth system dynamics. Potential applications include studies of the interactions and feedbacks leading to the timing, scale, and geographic distribution of emissions trajectories and other human influences, corresponding climate effects, and the subsequent impacts of a changing climate on human and natural systems. This paper describes the formulation, requirements, implementation, testing, and resulting functionality of the first version of the iESM released to the global climate community.« less

Clinician perceptions and patient experiences of antiretroviral treatment integration in primary health care clinics, Tshwane, South Africa.

PubMed

Mathibe, Maphuthego D; Hendricks, Stephen J H; Bergh, Anne-Marie

2015-10-02

Primary Health Care (PHC) clinicians and patients are major role players in the South African antiretroviral treatment programme. Understanding their perceptions and experiences of integrated care and the management of people living with HIV and AIDS in PHC facilities is necessary for successful implementation and sustainability of integration. This study explored clinician perceptions and patient experiences of integration of antiretroviral treatment in PHC clinics. An exploratory, qualitative study was conducted in four city of Tshwane PHC facilities. Two urban and two rural facilities following different models of integration were included. A self-administered questionnaire with open-ended items was completed by 35 clinicians and four focus group interviews were conducted with HIV-positive patients. The data were coded and categories were grouped into sub-themes and themes. Workload, staff development and support for integration affected clinicians' performance and viewpoints. They perceived promotion of privacy, reduced discrimination and increased access to comprehensive care as benefits of service integration. Delays, poor patient care and patient dissatisfaction were viewed as negative aspects of integration. In three facilities patients were satisfied with integration or semi-integration and felt common queues prevented stigma and discrimination, whilst the reverse was true in the facility with separate services. Single-month issuance of antiretroviral drugs and clinic schedule organisation was viewed negatively, as well as poor staff attitudes, poor communication and long waiting times. Although a fully integrated service model is preferable, aspects that need further attention are management support from health authorities for health facilities, improved working conditions and appropriate staff development opportunities.

Towards energy-efficient nonoscillatory forward-in-time integrations on lat-lon grids

NASA Astrophysics Data System (ADS)

Polkowski, Marcin; Piotrowski, Zbigniew; Ryczkowski, Adam

2017-04-01

The design of the next-generation weather prediction models calls for new algorithmic approaches allowing for robust integrations of atmospheric flow over complex orography at sub-km resolutions. These need to be accompanied by efficient implementations exposing multi-level parallelism, capable to run on modern supercomputing architectures. Here we present the recent advances in the energy-efficient implementation of the consistent soundproof/implicit compressible EULAG dynamical core of the COSMO weather prediction framework. Based on the experiences of the atmospheric dwarfs developed within H2020 ESCAPE project, we develop efficient, architecture agnostic implementations of fully three-dimensional MPDATA advection schemes and generalized diffusion operator in curvilinear coordinates and spherical geometry. We compare optimized Fortran implementation with preliminary C++ implementation employing the Gridtools library, allowing for integrations on CPU and GPU while maintaining single source code.

An integrated approach to conjunctive-use analysis with the one-water hydrologic flow model, MODFLOW-OWHM

USGS Publications Warehouse

Boyce, Scott E.; Hanson, Randall T.

2015-01-01

The MODFLOW-2005 (MF) family of hydrologic simulators has diverged into multiple versions designed for specific needs, thus limiting their use to their respective designs. The One-Water Hydrologic Flow Model (MF-OWHM v1.0) is an integrated hydrologic flow model that is an enhanced fusion of multiple MF versions. While maintaining compatibility with existing MF versions, MF-OWHM includes: linkages for coupled heads, flows, and deformation; facilitation of self-updating models, additional observation and parameter options for higher-order calibrations; and redesigned code for faster simulations. This first release of MF-OWHM incorporates MODFLOW-2005 and the Farm Process (MF-FMP2), with new features (FMP3), combined with Local Grid Refinement (MF-LGR), Streamflow Routing (SFR), Surfacewater Routing Process (SWR), Seawater Intrusion (SWI), Riparian Evapotranspiration (RIP-ET), the Newton Formulation (MF-NWT), and more. MF-OWHM represents a complete integrated hydrologic model that fully links the movement and use of groundwater, surface water, and imported water for consumption by agriculture and natural vegetation on the landscape, and for potable and other uses. By retaining and keeping track of the water during simulation of the hydrosphere, MF-OWHM accounts for “all of the water everywhere and all of the time.” This provides the foundation needed to address integrated hydrologic problems such as evaluation of conjunctive-use alternatives and sustainability analysis, including potential adaptation and mitigation strategies, and best management practices.

Multi-ray-based system matrix generation for 3D PET reconstruction

NASA Astrophysics Data System (ADS)

Moehrs, Sascha; Defrise, Michel; Belcari, Nicola; DelGuerra, Alberto; Bartoli, Antonietta; Fabbri, Serena; Zanetti, Gianluigi

2008-12-01

Iterative image reconstruction algorithms for positron emission tomography (PET) require a sophisticated system matrix (model) of the scanner. Our aim is to set up such a model offline for the YAP-(S)PET II small animal imaging tomograph in order to use it subsequently with standard ML-EM (maximum-likelihood expectation maximization) and OSEM (ordered subset expectation maximization) for fully three-dimensional image reconstruction. In general, the system model can be obtained analytically, via measurements or via Monte Carlo simulations. In this paper, we present the multi-ray method, which can be considered as a hybrid method to set up the system model offline. It incorporates accurate analytical (geometric) considerations as well as crystal depth and crystal scatter effects. At the same time, it has the potential to model seamlessly other physical aspects such as the positron range. The proposed method is based on multiple rays which are traced from/to the detector crystals through the image volume. Such a ray-tracing approach itself is not new; however, we derive a novel mathematical formulation of the approach and investigate the positioning of the integration (ray-end) points. First, we study single system matrix entries and show that the positioning and weighting of the ray-end points according to Gaussian integration give better results compared to equally spaced integration points (trapezoidal integration), especially if only a small number of integration points (rays) are used. Additionally, we show that, for a given variance of the single matrix entries, the number of rays (events) required to calculate the whole matrix is a factor of 20 larger when using a pure Monte-Carlo-based method. Finally, we analyse the quality of the model by reconstructing phantom data from the YAP-(S)PET II scanner.

A Fully Integrated Micro-Magnometer/Microspacecraft for Multipoint Measurements: The Free-Flyer Magnometer

NASA Technical Reports Server (NTRS)

Goldstein, R.; Miller, L. N.; Fossum, E.; Pain, B.; Randolph, J. E.; Turner, P. R.; Cutting, E.

1995-01-01

In the decades since the advent of in situ plasma measurements on board spacecraft, the instrumentation has grown bigger, heavier, and more complex as our understanding of space plasmas improves and our appetite for more information increases...There has thus been a recent interest in the miniaturization of both spacecraft and the instrument payload... This paper describes the results and status of an ongoing design study to understand the problems and trade space of fully integrating an instrument into a micro-spacecraft.

Note: Fully integrated active quenching circuit achieving 100 MHz count rate with custom technology single photon avalanche diodes.

PubMed

Acconcia, G; Labanca, I; Rech, I; Gulinatti, A; Ghioni, M

2017-02-01

The minimization of Single Photon Avalanche Diodes (SPADs) dead time is a key factor to speed up photon counting and timing measurements. We present a fully integrated Active Quenching Circuit (AQC) able to provide a count rate as high as 100 MHz with custom technology SPAD detectors. The AQC can also operate the new red enhanced SPAD and provide the timing information with a timing jitter Full Width at Half Maximum (FWHM) as low as 160 ps.

Integrating high dimensional bi-directional parsing models for gene mention tagging.

PubMed

Hsu, Chun-Nan; Chang, Yu-Ming; Kuo, Cheng-Ju; Lin, Yu-Shi; Huang, Han-Shen; Chung, I-Fang

2008-07-01

Tagging gene and gene product mentions in scientific text is an important initial step of literature mining. In this article, we describe in detail our gene mention tagger participated in BioCreative 2 challenge and analyze what contributes to its good performance. Our tagger is based on the conditional random fields model (CRF), the most prevailing method for the gene mention tagging task in BioCreative 2. Our tagger is interesting because it accomplished the highest F-scores among CRF-based methods and second over all. Moreover, we obtained our results by mostly applying open source packages, making it easy to duplicate our results. We first describe in detail how we developed our CRF-based tagger. We designed a very high dimensional feature set that includes most of information that may be relevant. We trained bi-directional CRF models with the same set of features, one applies forward parsing and the other backward, and integrated two models based on the output scores and dictionary filtering. One of the most prominent factors that contributes to the good performance of our tagger is the integration of an additional backward parsing model. However, from the definition of CRF, it appears that a CRF model is symmetric and bi-directional parsing models will produce the same results. We show that due to different feature settings, a CRF model can be asymmetric and the feature setting for our tagger in BioCreative 2 not only produces different results but also gives backward parsing models slight but constant advantage over forward parsing model. To fully explore the potential of integrating bi-directional parsing models, we applied different asymmetric feature settings to generate many bi-directional parsing models and integrate them based on the output scores. Experimental results show that this integrated model can achieve even higher F-score solely based on the training corpus for gene mention tagging. Data sets, programs and an on-line service of our gene mention tagger can be accessed at http://aiia.iis.sinica.edu.tw/biocreative2.htm.

A highly linear fully integrated powerline filter for biopotential acquisition systems.

PubMed

Alzaher, Hussain A; Tasadduq, Noman; Mahnashi, Yaqub

2013-10-01

Powerline interference is one of the most dominant problems in detection and processing of biopotential signals. This work presents a new fully integrated notch filter exhibiting high linearity and low power consumption. High filter linearity is preserved utilizing active-RC approach while IC implementation is achieved through replacing passive resistors by R-2R ladders achieving area saving of approximately 120 times. The filter design is optimized for low power operation using an efficient circuit topology and an ultra-low power operational amplifier. Fully differential implementation of the proposed filter shows notch depth of 43 dB (78 dB for 4th-order) with THD of better than -70 dB while consuming about 150 nW from 1.5 V supply.

Registered dietitian nutritionists bring value to emerging health care delivery models.

PubMed

Jortberg, Bonnie T; Fleming, Michael O

2014-12-01

Health care in the United States is the most expensive in the world; however, most citizens do not receive quality care that is comprehensive and coordinated. To address this gap, the Institute for Healthcare Improvement developed the Triple Aim (ie, improving population health, improving the patient experience, and reducing costs), which has been adopted by patient-centered medical homes and accountable care organizations. The patient-centered medical home and other population health models focus on improving the care for all people, particularly those with multiple morbidities. The Joint Principles of the Patient-Centered Medical Home, developed by the major primary care physician organizations in 2007, recognizes the key role of the multidisciplinary team in meeting the challenge of caring for these individuals. Registered dietitian nutritionists (RDNs) bring value to this multidisciplinary team by providing care coordination, evidence-based care, and quality-improvement leadership. RDNs have demonstrated efficacy for improvements in outcomes for patients with a wide variety of medical conditions. Primary care physicians, as well as several patient-centered medical home and population health demonstration projects, have reported the benefits of RDNs as part of the integrated primary care team. One of the most significant barriers to integrating RDNs into primary care has been an insufficient reimbursement model. Newer innovative payment models provide the opportunity to overcome this barrier. In order to achieve this integration, the Academy of Nutrition and Dietetics and RDNs must fully understand and embrace the opportunities and challenges that the new health care delivery and payment models present, and be prepared and empowered to lead the necessary changes. All stakeholders within the health care system need to more fully recognize and embrace the value and multidimensional role of the RDN on the multidisciplinary team. The Academy's Patient-Centered Medical Home/Accountable Care Organizations Workgroup Report provides a framework for the Academy, its members, and key partners to use to achieve this goal. Copyright © 2014 Academy of Nutrition and Dietetics. Published by Elsevier Inc. All rights reserved.

PV_LIB Toolbox

DOE Office of Scientific and Technical Information (OSTI.GOV)

2012-09-11

While an organized source of reference information on PV performance modeling is certainly valuable, there is nothing to match the availability of actual examples of modeling algorithms being used in practice. To meet this need, Sandia has developed a PV performance modeling toolbox (PV_LIB) for Matlab. It contains a set of well-documented, open source functions and example scripts showing the functions being used in practical examples. This toolbox is meant to help make the multi-step process of modeling a PV system more transparent and provide the means for model users to validate and understand the models they use and ormore » develop. It is fully integrated into Matlab's help and documentation utilities. The PV_LIB Toolbox provides more than 30 functions that are sorted into four categories« less

Biomimetic engineered muscle with capacity for vascular integration and functional maturation in vivo

PubMed Central

Juhas, Mark; Engelmayr, George C.; Fontanella, Andrew N.; Palmer, Gregory M.; Bursac, Nenad

2014-01-01

Tissue-engineered skeletal muscle can serve as a physiological model of natural muscle and a potential therapeutic vehicle for rapid repair of severe muscle loss and injury. Here, we describe a platform for engineering and testing highly functional biomimetic muscle tissues with a resident satellite cell niche and capacity for robust myogenesis and self-regeneration in vitro. Using a mouse dorsal window implantation model and transduction with fluorescent intracellular calcium indicator, GCaMP3, we nondestructively monitored, in real time, vascular integration and the functional state of engineered muscle in vivo. During a 2-wk period, implanted engineered muscle exhibited a steady ingrowth of blood-perfused microvasculature along with an increase in amplitude of calcium transients and force of contraction. We also demonstrated superior structural organization, vascularization, and contractile function of fully differentiated vs. undifferentiated engineered muscle implants. The described in vitro and in vivo models of biomimetic engineered muscle represent enabling technology for novel studies of skeletal muscle function and regeneration. PMID:24706792

Understanding future emissions from low-carbon power systems by integration of life-cycle assessment and integrated energy modelling

NASA Astrophysics Data System (ADS)

Pehl, Michaja; Arvesen, Anders; Humpenöder, Florian; Popp, Alexander; Hertwich, Edgar G.; Luderer, Gunnar

2017-12-01

Both fossil-fuel and non-fossil-fuel power technologies induce life-cycle greenhouse gas emissions, mainly due to their embodied energy requirements for construction and operation, and upstream CH4 emissions. Here, we integrate prospective life-cycle assessment with global integrated energy-economy-land-use-climate modelling to explore life-cycle emissions of future low-carbon power supply systems and implications for technology choice. Future per-unit life-cycle emissions differ substantially across technologies. For a climate protection scenario, we project life-cycle emissions from fossil fuel carbon capture and sequestration plants of 78-110 gCO2eq kWh-1, compared with 3.5-12 gCO2eq kWh-1 for nuclear, wind and solar power for 2050. Life-cycle emissions from hydropower and bioenergy are substantial (˜100 gCO2eq kWh-1), but highly uncertain. We find that cumulative emissions attributable to upscaling low-carbon power other than hydropower are small compared with direct sectoral fossil fuel emissions and the total carbon budget. Fully considering life-cycle greenhouse gas emissions has only modest effects on the scale and structure of power production in cost-optimal mitigation scenarios.

Endangered Mangroves in Segara Anakan, Indonesia: Effective and Failed Problem-Solving Policy Advice.

PubMed

Dharmawan, Budi; Böcher, Michael; Krott, Max

2017-09-01

The success of scientific knowledge transfer depends on if the decision maker can transform the scientific advice into a policy that can be accepted by all involved actors. We use a science-policy interactions model called research-integration-utilization to observe the process of scientific knowledge transfer in the case of endangered mangroves in Segara Anakan, Indonesia. Scientific knowledge is produced within the scientific system (research), science-based solutions to problems are practically utilized by political actors (utilization), and important links between research and utilization must be made (integration). We looked for empirical evidence to test hypotheses about the research-integration-utilization model based on document analysis and expert interviews. Our study finds that the failures in knowledge transfer are caused by the inappropriate use of scientific findings. The district government is expected by presidential decree to only used scientifically sound recommendations as a prerequisite for designing the regulation. However, the district government prefers to implement their own solutions because they believe that they understand the solutions better than the researcher. In the process of integration, the researcher cannot be involved, since the selection of scientific recommendations here fully depends on the interests of the district government as the powerful ally.

Endangered Mangroves in Segara Anakan, Indonesia: Effective and Failed Problem-Solving Policy Advice

NASA Astrophysics Data System (ADS)

Dharmawan, Budi; Böcher, Michael; Krott, Max

2017-09-01

The success of scientific knowledge transfer depends on if the decision maker can transform the scientific advice into a policy that can be accepted by all involved actors. We use a science-policy interactions model called research-integration-utilization to observe the process of scientific knowledge transfer in the case of endangered mangroves in Segara Anakan, Indonesia. Scientific knowledge is produced within the scientific system (research), science-based solutions to problems are practically utilized by political actors (utilization), and important links between research and utilization must be made (integration). We looked for empirical evidence to test hypotheses about the research-integration-utilization model based on document analysis and expert interviews. Our study finds that the failures in knowledge transfer are caused by the inappropriate use of scientific findings. The district government is expected by presidential decree to only used scientifically sound recommendations as a prerequisite for designing the regulation. However, the district government prefers to implement their own solutions because they believe that they understand the solutions better than the researcher. In the process of integration, the researcher cannot be involved, since the selection of scientific recommendations here fully depends on the interests of the district government as the powerful ally.

Implementation of an integrated op-amp based chaotic neuron model and observation of its chaotic dynamics

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jung, Jinwoo; Lee, Jewon; Song, Hanjung

2011-03-15

This paper presents a fully integrated circuit implementation of an operational amplifier (op-amp) based chaotic neuron model with a bipolar output function, experimental measurements, and analyses of its chaotic behavior. The proposed chaotic neuron model integrated circuit consists of several op-amps, sample and hold circuits, a nonlinear function block for chaotic signal generation, a clock generator, a nonlinear output function, etc. Based on the HSPICE (circuit program) simulation results, approximated empirical equations for analyses were formulated. Then, the chaotic dynamical responses such as bifurcation diagrams, time series, and Lyapunov exponent were calculated using these empirical equations. In addition, we performedmore » simulations about two chaotic neuron systems with four synapses to confirm neural network connections and got normal behavior of the chaotic neuron such as internal state bifurcation diagram according to the synaptic weight variation. The proposed circuit was fabricated using a 0.8-{mu}m single poly complementary metal-oxide semiconductor technology. Measurements of the fabricated single chaotic neuron with {+-}2.5 V power supplies and a 10 kHz sampling clock frequency were carried out and compared with the simulated results.« less

Integrated Modeling of Aerosol, Cloud, Precipitation and Land Processes at Satellite-Resolved Scales

NASA Technical Reports Server (NTRS)

Peters-Lidard, Christa; Tao, Wei-Kuo; Chin, Mian; Braun, Scott; Case, Jonathan; Hou, Arthur; Kumar, Anil; Kumar, Sujay; Lau, William; Matsui, Toshihisa;

A data-driven emulation framework for representing water-food nexus in a changing cold region

NASA Astrophysics Data System (ADS)

Nazemi, A.; Zandmoghaddam, S.; Hatami, S.

2017-12-01

Water resource systems are under increasing pressure globally. Growing population along with competition between water demands and emerging effects of climate change have caused enormous vulnerabilities in water resource management across many regions. Diagnosing such vulnerabilities and provision of effective adaptation strategies requires the availability of simulation tools that can adequately represent the interactions between competing water demands for limiting water resources and inform decision makers about the critical vulnerability thresholds under a range of potential natural and anthropogenic conditions. Despite a significant progress in integrated modeling of water resource systems, regional models are often unable to fully represent the contemplating dynamics within the key elements of water resource systems locally. Here we propose a data-driven approach to emulate a complex regional water resource system model developed for Oldman River Basin in southern Alberta, Canada. The aim of the emulation is to provide a detailed understanding of the trade-offs and interaction at the Oldman Reservoir, which is the key to flood control and irrigated agriculture in this over-allocated semi-arid cold region. Different surrogate models are developed to represent the dynamic of irrigation demand and withdrawal as well as reservoir evaporation and release individually. The nan-falsified offline models are then integrated through the water balance equation at the reservoir location to provide a coupled model for representing the dynamic of reservoir operation and water allocation at the local scale. The performance of individual and integrated models are rigorously examined and sources of uncertainty are highlighted. To demonstrate the practical utility of such surrogate modeling approach, we use the integrated data-driven model for examining the trade-off in irrigation water supply, reservoir storage and release under a range of changing climate, upstream streamflow and local irrigation conditions.

Environmental Management Competitive Pressure Effect on SME Environmental Innovation Activities: A Green Supply Chain Perspective

NASA Astrophysics Data System (ADS)

Rashid, A. A.; Sidek, A. A.; Suffian, S. A.; Daud, M. R. C.

2018-01-01

The idea of assimilating green supply chain is to integrate and establish environmental management into the supply chain practices. The study aims to explore how environmental management competitive pressure influences a SME company in Malaysia to incorporate green supply chain integration, which is an efficient platform to develop environmental innovation. This study further advances green supply chain management research in Malaysia by using the method of quantitative analysis to analyze the model developed which data will be collected based on a sample of SMEs in Malaysia in manufacturing sector. The model developed in this study illustrates how environmental management competitive pressure from main competitors affects three fundamental dimensions of green supply chain integration. The research findings suggest that environmental management competitive pressure is a vital driving force for a SME company to incorporate internal and external collaboration in developing green product innovation. From the analysis conducted, the study strongly demonstrated that the best way for a company to counteract competitor’s environmental management success is to first implement strong internal green product development process then move to incorporate external environmental management innovation between their suppliers and customers. The findings also show that internal integration of green product innovation fully mediates the relationship of environmental management competitive pressure and the external integration of green product innovation.

On the integration of financial markets: How strong is the evidence from five international stock markets?

NASA Astrophysics Data System (ADS)

Bentes, Sónia R.

2015-07-01

This paper examines the integration of financial markets using data from five international stock markets in the context of globalization. The theoretical basis of this study relies on the price theory and the Law of One Price, which was adjusted to the framework of financial markets. When price levels are nonstationary, cointegration and the error correction model constitute a powerful tool for the empirical examination of market integration. The error correction model provides a fully dynamic framework that allows to separating the long and the short run effects of the integration process. A dataset encompassing the daily stock price series of the PSI 20 (Portugal), IBEX 35 (Spain), FTSE 100 (UK), NIKKEI 225 (Japan) and SP 500 (US) indices from January 4th 1999 to September 19th 2014 is employed. The results highlight that these five stock markets are linked together by just one long-run relationship, although short-run movements are also present, which causes distinct deviations from the long-run equilibrium relationship. Endogeneity prevails in the system as a whole. While market integration in the sense of the Law of One Price holds, pairwise full price transmission has limited evidence. The results therefore show that stock market price movements are highly nonlinear and complex.

Direct correlation between potentiometric and impedance biosensing of antibody-antigen interactions using an integrated system

NASA Astrophysics Data System (ADS)

Tsai, Meng-Yen; Creedon, Niamh; Brightbill, Eleanor; Pavlidis, Spyridon; Brown, Billyde; Gray, Darren W.; Shields, Niall; Sayers, Ríona; Mooney, Mark H.; O'Riordan, Alan; Vogel, Eric M.

2017-08-01

A fully integrated system that combines extended gate field-effect transistor (EGFET)-based potentiometric biosensors and electrochemical impedance spectroscopy (EIS)-based biosensors has been demonstrated. This integrated configuration enables the sequential measurement of the same immunological binding event on the same sensing surface and consequently sheds light on the fundamental origins of sensing signals produced by FET and EIS biosensors, as well as the correlation between the two. Detection of both the bovine serum albumin (BSA)/anti-BSA model system in buffer solution and bovine parainfluenza antibodies in complex blood plasma samples was demonstrated using the integrated biosensors. Comparison of the EGFET and EIS sensor responses reveals similar dynamic ranges, while equivalent circuit modeling of the EIS response shows that the commonly reported total impedance change (ΔZtotal) is dominated by the change in charge transfer resistance (Rct) rather than surface capacitance (Csurface). Using electrochemical kinetics and the Butler-Volmer equation, we unveil that the surface potential and charge transfer resistance, measured by potentiometric and impedance biosensors, respectively, are, in fact, intrinsically linked. This observation suggests that there is no significant gain in using the FET/EIS integrated system and leads to the demonstration that low-cost EGFET biosensors are sufficient as a detection tool to resolve the charge information of biomolecules for practical sensing applications.

Air emissions of ammonia and methane from livestock operations: valuation and policy options.

PubMed

Shih, Jhih-Shyang; Burtraw, Dallas; Palmer, Karen; Siikamäki, Juha

2008-09-01

The animal husbandry industry is a major emitter of ammonia (NH3), which is a precursor of fine particulate matter (PM2.5)--arguably, the number-one environment-related public health threat facing the nation. The industry is also a major emitter of methane (CH4), which is an important greenhouse gas (GHG). We present an integrated process model of the engineering economics of technologies to reduce NH3 and CH4 emissions at dairy operations in California. Three policy options are explored: PM offset credits for NH3 control, GHG offset credits for CH4 control, and expanded net metering policies to provide revenue for the sale of electricity generated from captured methane (CH4) gas. Individually these policies vary substantially in the economic incentives they provide for farm operators to reduce emissions. We report on initial steps to fully develop the integrated process model that will provide guidance for policy-makers.

Towards an integrated understanding of gut microbiota using insects as model systems.

PubMed

Pernice, Mathieu; Simpson, Stephen J; Ponton, Fleur

2014-10-01

Metazoans form symbioses with microorganisms that synthesize essential nutritional compounds and increase their efficiency to digest and absorb nutrients. Despite the growing awareness that microbes within the gut play key roles in metabolism, health and development of metazoans, symbiotic relationships within the gut are far from fully understood. Insects, which generally harbor a lower microbial diversity than vertebrates, have recently emerged as potential model systems to study these interactions. In this review, we give a brief overview of the characteristics of the gut microbiota in insects in terms of low diversity but high variability at intra- and interspecific levels and we investigate some of the ecological and methodological factors that might explain such variability. We then emphasize how studies integrating an array of techniques and disciplines have the potential to provide new understanding of the biology of this micro eco-system. Crown Copyright © 2014. Published by Elsevier Ltd. All rights reserved.

Semiotic diversity in utterance production and the concept of ‘language’

PubMed Central

Kendon, Adam

2014-01-01

Sign language descriptions that use an analytic model borrowed from spoken language structural linguistics have proved to be not fully appropriate. Pictorial and action-like modes of expression are integral to how signed utterances are constructed and to how they work. However, observation shows that speakers likewise use kinesic and vocal expressions that are not accommodated by spoken language structural linguistic models, including pictorial and action-like modes of expression. These, also, are integral to how speaker utterances in face-to-face interaction are constructed and to how they work. Accordingly, the object of linguistic inquiry should be revised, so that it comprises not only an account of the formal abstract systems that utterances make use of, but also an account of how the semiotically diverse resources that all languaging individuals use are organized in relation to one another. Both language as an abstract system and languaging should be the concern of linguistics. PMID:25092661

[Lübeck University Model for Physiotherapy].

PubMed

Bretin, Annette; Großmann, Kirsten; Schulz, ArndtPeter

2018-02-19

The aim of this paper is to describe the development of an innovative bachelor's degree program for physiotherapy directly affiliated with the medical department, which is a unique approach to making physiotherapy an academic course in Germany. The previous system for qualifying as a physiotherapist was amended by the adaption of qualification objectives resulting in a model that links scientific and vocational knowledge from the beginning of the study. Several lectures support interprofessionality. The vocational training is fully integrated into the curriculum. The exemplary concept is monitored by an extensive quality management program. The approach meets general recommendations of experts and can serve as a model for other universities. © Georg Thieme Verlag KG Stuttgart · New York.

Transformation of Graphical ECA Policies into Executable PonderTalk Code

NASA Astrophysics Data System (ADS)

Romeikat, Raphael; Sinsel, Markus; Bauer, Bernhard

Rules are becoming more and more important in business modeling and systems engineering and are recognized as a high-level programming paradigma. For the effective development of rules it is desired to start at a high level, e.g. with graphical rules, and to refine them into code of a particular rule language for implementation purposes later. An model-driven approach is presented in this paper to transform graphical rules into executable code in a fully automated way. The focus is on event-condition-action policies as a special rule type. These are modeled graphically and translated into the PonderTalk language. The approach may be extended to integrate other rule types and languages as well.

Planetary Moon Cycler Trajectories

NASA Technical Reports Server (NTRS)

Russell, Ryan P.; Strange, Nathan J.

2007-01-01

Free-return cycler trajectories repeatedly shuttle a spacecraft between two bodies using little or no fuel. Here, the cycler architecture is proposed as a complementary and alternative method for designing planetary moon tours. Previously applied enumerative cycler search and optimization techniques are generalized and specifically implemented in the Jovian and Saturnian moon systems. In addition, the algorithms are tested for general use to find non-Earth heliocentric cyclers. Overall, hundreds of ideal model ballistic cycler geometries are found and several representative cases are documented and discussed. Many of the ideal model solutions are found to remain ballistic in a zero radius sphere of influence patched conic ephemeris model, and preliminary work in a high-fidelity fully integrated model demonstrates near-ballistic cycles for several example cases.

River Devices to Recover Energy with Advanced Materials (River DREAM)

DOE Office of Scientific and Technical Information (OSTI.GOV)

McMahon, Daniel P.

2013-07-03

The purpose of this project is to develop a generator called a Galloping Hydroelectric Energy Extraction Device (GHEED). It uses a galloping prism to convert water flow into linear motion. This motion is converted into electricity via a dielectric elastomer generator (DEG). The galloping mechanism and the DEG are combined to create a system to effectively generate electricity. This project has three research objectives: 1. Oscillator development and design a. Characterize galloping behavior, evaluate control surface shape change on oscillator performance and demonstrate shape change with water flow change. 2. Dielectric Energy Generator (DEG) characterization and modeling a. Characterize andmore » model the performance of the DEG based on oscillator design 3. Galloping Hydroelectric Energy Extraction Device (GHEED) system modeling and integration a. Create numerical models for construction of a system performance model and define operating capabilities for this approach Accomplishing these three objectives will result in the creation of a model that can be used to fully define the operating parameters and performance capabilities of a generator based on the GHEED design. This information will be used in the next phase of product development, the creation of an integrated laboratory scale generator to confirm model predictions.« less

Prioritization Risk Integration Simulation Model (PRISM) For Environmental Remediation and Waste Management - 12097

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pentz, David L.; Stoll, Ralph H.; Greeves, John T.

2012-07-01

The PRISM (Prioritization Risk Integration Simulation Model), a computer model was developed to support the Department of Energy's Office of Environmental Management (DOE-EM) in its mission to clean up the environmental legacy from the Nation's nuclear weapons materials production complex. PRISM provides a comprehensive, fully integrated planning tool that can tie together DOE-EM's projects. It is designed to help DOE managers develop sound, risk-informed business practices and defend program decisions. It provides a better ability to understand and manage programmatic risks. The underlying concept for PRISM is that DOE-EM 'owns' a portfolio of environmental legacy obligations (ELOs), and that itsmore » mission is to transform the ELOs from their current conditions to acceptable conditions, in the most effective way possible. There are many types of ELOs - - contaminated soils and groundwater plumes, disused facilities awaiting D and D, and various types of wastes waiting for processing or disposal. For a given suite of planned activities, PRISM simulates the outcomes as they play out over time, allowing for all key identified uncertainties and risk factors. Each contaminated building, land area and waste stream is tracked from cradle to grave, and all of the linkages affecting different waste streams are captured. The progression of the activities is fully dynamic, reflecting DOE-EM's prioritization approaches, precedence requirements, available funding, and the consequences of risks and uncertainties. The top level of PRISM is the end-user interface that allows rapid evaluation of alternative scenarios and viewing the results in a variety of useful ways. PRISM is a fully probabilistic model, allowing the user to specify uncertainties in input data (such as the magnitude of an existing groundwater plume, or the total cost to complete a planned activity) as well as specific risk events that might occur. PRISM is based on the GoldSim software that is widely used for risk and performance assessment calculations. PRISM can be run in a deterministic mode, which quickly provides an estimate of the most likely results of a given plan. Alternatively, the model can be run probabilistically in a Monte Carlo mode, exploring the risks and uncertainties in the system and producing probability distributions for the different performance measures. The PRISM model demonstrates how EM can evaluate a portfolio of ELOs, and transform the ELOs from their current conditions to acceptable conditions, utilizing different strategic approaches. There are many types of ELOs - contaminated soils and groundwater plumes, disused facilities awaiting D and D, and various types of wastes waiting for processing or disposal. This scope of work for the PRISM process and the development of a dynamic simulation model are a logical extension of the GoldSim simulation software used by the OCRWM to assess the long-term performance for the Yucca Mountain Project and by NNSA to assess project risk at its sites. Systems integration modeling will promote better understanding of all project risks, technical and nontechnical, and more defensible decision-making for complex projects with significant uncertainties. It can provide effective visual communication and rapid adaptation during interactions with stakeholders (Administration, Congress, State, Local, and NGO). It will also allow rapid assessment of alternative management approaches. (authors)« less

First Year Teachers Technology Use: Perceptions of Factors Affecting Technology Integration

ERIC Educational Resources Information Center

Jones, Elodie J.

2013-01-01

For decades, technology integration into the classroom and curriculum has been at the forefront of education. Although public perception and technology funding assumes that teachers are integrating technology into the curriculum, research shows that actual integration is still far from being fully implemented. This study detailed how first-year…

Integration of Gross Anatomy in an Organ System-Based Medical Curriculum: Strategies and Challenges

ERIC Educational Resources Information Center

Brooks, William S.; Woodley, Kristina T. C. Panizzi; Jackson, James R.; Hoesley, Craig J.

2015-01-01

The University of Alabama School of Medicine (UASOM) instituted a fully integrated, organ system-based preclinical curriculum in 2007. Gross anatomy and embryology were integrated with other basic science disciplines throughout the first two years of undergraduate medical education. Here we describe the methods of instruction and integration of…

Discussion on Reformation of Biotechnological Pharmacy Experimental Teaching

NASA Astrophysics Data System (ADS)

Wen, Zhang; Yanjun, Li; Qiao, Zeng

This article constructs a "comprehensive-designable-innovation" multi-level experimental teaching model, through integrating related disciplines courses, updating biopharmaceutical experiment teaching content, adding designing and innovation experiment item. During the teaching, the teacher mobilizes and stimulates the students' learning interest, enthusiasm and initiative fully by adopting the opening experiment teaching mode. The experiment not only consolidates the students' theory knowledge, makes them master the basic skills of biological pharmacy experiment, but also cultivates the students' independent innovating and independent ability.

Multisensor-integrated organs-on-chips platform for automated and continual in situ monitoring of organoid behaviors

PubMed Central

Zhang, Yu Shrike; Aleman, Julio; Shin, Su Ryon; Kim, Duckjin; Mousavi Shaegh, Seyed Ali; Massa, Solange; Riahi, Reza; Chae, Sukyoung; Hu, Ning; Avci, Huseyin; Zhang, Weijia; Silvestri, Antonia; Sanati Nezhad, Amir; Manbohi, Ahmad; De Ferrari, Fabio; Polini, Alessandro; Calzone, Giovanni; Shaikh, Noor; Alerasool, Parissa; Budina, Erica; Kang, Jian; Bhise, Nupura; Pourmand, Adel; Skardal, Aleksander; Shupe, Thomas; Bishop, Colin E.; Dokmeci, Mehmet Remzi; Atala, Anthony; Khademhosseini, Ali

2017-01-01

Organ-on-a-chip systems are miniaturized microfluidic 3D human tissue and organ models designed to recapitulate the important biological and physiological parameters of their in vivo counterparts. They have recently emerged as a viable platform for personalized medicine and drug screening. These in vitro models, featuring biomimetic compositions, architectures, and functions, are expected to replace the conventional planar, static cell cultures and bridge the gap between the currently used preclinical animal models and the human body. Multiple organoid models may be further connected together through the microfluidics in a similar manner in which they are arranged in vivo, providing the capability to analyze multiorgan interactions. Although a wide variety of human organ-on-a-chip models have been created, there are limited efforts on the integration of multisensor systems. However, in situ continual measuring is critical in precise assessment of the microenvironment parameters and the dynamic responses of the organs to pharmaceutical compounds over extended periods of time. In addition, automated and noninvasive capability is strongly desired for long-term monitoring. Here, we report a fully integrated modular physical, biochemical, and optical sensing platform through a fluidics-routing breadboard, which operates organ-on-a-chip units in a continual, dynamic, and automated manner. We believe that this platform technology has paved a potential avenue to promote the performance of current organ-on-a-chip models in drug screening by integrating a multitude of real-time sensors to achieve automated in situ monitoring of biophysical and biochemical parameters. PMID:28265064

13A. Integrative Cancer Care: The Life Over Cancer Model

PubMed Central

Block, Keith; Block, Penny; Shoham, Jacob

2013-01-01

Focus Areas: Integrative Algorithms of Care Integrative cancer treatment fully blends conventional cancer treatment with integrative therapies such as diet, supplements, exercise and biobehavioral approaches. The Life Over Cancer model comprises three spheres of intervention: improving lifestyle, improving biochemical environment (terrain), and improving tolerance of conventional treatment. These levels are applied within the context of a life-affirming approach to cancer patients and treatment. Clinical staff involved include MDs, psychosocial, physical therapy, and dietetic professionals, all located in a single private clinic, the Block Center for Integrative Cancer Treatment. This session will describe the rationale and operation of the clinical model. An outpatient chemotherapy unit is incorporated in the clinic. Chronomodulated chemotherapy is used for selected chemotherapy drugs. Physical care includes massage, exercise and other therapies as directed by the center's physical therapy staff. Notably, cancer patients who are physically active have lower mortality and recurrence risks. Behavioral approaches are being shown increasingly to affect physiological parameters and expression of genes potentially related to cancer. Thus, biobehavioral approaches such as relaxed abdominal breathing and comfort space imagery are taught to patients by a staff including a clinical psychologist and other practitioners. Nutrition is also emerging as a relevant area of intervention in cancer, with recent guidelines from the American Cancer Society. A team of registered dietitians counsels patients individually and conducts cooking classes. Finally, the Life Over Cancer model includes analysis of multiple biological parameters relevant to cancer and general health, with standard laboratory tests. Inflammation, glycemic variables, immune functioning and other variables are regularly monitored. Dietary changes and where necessary supplements are suggested when laboratory results are abnormal. Interaction of supplements with cancer treatment drugs is monitored. The session will highlight the roles played by both conventional and integrative therapies in the treatment of cancer patients.

Integrating Antarctic Science Into Geospace System Science

NASA Astrophysics Data System (ADS)

Kelly, J. D.

2010-12-01

Addressing the scientific, technical, and sociological challenges of the future requires both detailed basic research and system based approaches to the entire geospace system from the Earth’s core, through solid Earth, ice, oceans, atmosphere, ionosphere, and magnetosphere to the Sun’s outer atmosphere and even beyond. Fully integrating Antarctic science, and fully exploiting the scientific research possibilities of the Antarctic continent through effective and efficient support infrastructure, will be a very important contribution to future success. Amongst many new facilities and programs which can and are being proposed, the Moveable Antarctic Incoherent Scatter Radar (MAISR) at McMurdo illustrates the potential for innovative future science. This poster uses some of the proposed science programs to show how the scientific community can use the data products of this facility, and how they can contribute to the development of the tools and mechanisms for proposing, executing, and utilizing such new research capabilities. In particular, incoherent scatter radars played a big role in data collection during the recent International Polar Year and plans for future extended operations, including those in Antarctica, will be discussed in the light of lessons learnt in applying observations to global modeling developments.

Fully Integrated e-Services for Prevention, Diagnosis, and Treatment of Sexually Transmitted Infections: Results of a 4-County Study in California

PubMed Central

Levy, Vivian; Lensing, Shelly; Chattopadhyay, Ishita; Venkatasubramanian, Lalitha; Acevedo, Nincoshka; Wolff, Peter; Callabresi, Debra; Philip, Susan; Lopez, Teresa P.; Padian, Nancy; Blake, Diane R.; Gaydos, Charlotte A.

2014-01-01

Objectives. We examined the acceptability, feasibility, and cost of a fully integrated online system (eSTI) for sexually transmitted infection (STI) testing, treatment, and linkage to care with 4 Northern California health departments. Methods. In April 2012, we implemented the eSTI system, which provided education; testing of self-collected vaginal swabs for chlamydia, gonorrhea, and trichomoniasis; e-prescriptions; e-partner notification; and data integration with clinic electronic health records. We analyzed feasibility, acceptability, and cost measures. Results. During a 3-month period, 217 women aged 18 to 30 years enrolled; 67% returned the kit. Of these, 92% viewed their results online. STI prevalence was 5.6% (chlamydia and trichomoniasis). All participants with STIs received treatment either the same day at a pharmacy (62%) or within 7 days at a clinic (38%). Among participants completing follow-up surveys, 99% would recommend the online eSTI system to a friend, and 95% preferred it over clinic-based testing within a study. Conclusions. The fully integrated eSTI system has the potential to increase diagnosis and treatment of STIs with higher patient satisfaction at a potentially lower cost. PMID:25320878

Fully integrated e-services for prevention, diagnosis, and treatment of sexually transmitted infections: results of a 4-county study in California.

PubMed

Spielberg, Freya; Levy, Vivian; Lensing, Shelly; Chattopadhyay, Ishita; Venkatasubramanian, Lalitha; Acevedo, Nincoshka; Wolff, Peter; Callabresi, Debra; Philip, Susan; Lopez, Teresa P; Padian, Nancy; Blake, Diane R; Gaydos, Charlotte A

2014-12-01

We examined the acceptability, feasibility, and cost of a fully integrated online system (eSTI) for sexually transmitted infection (STI) testing, treatment, and linkage to care with 4 Northern California health departments. In April 2012, we implemented the eSTI system, which provided education; testing of self-collected vaginal swabs for chlamydia, gonorrhea, and trichomoniasis; e-prescriptions; e-partner notification; and data integration with clinic electronic health records. We analyzed feasibility, acceptability, and cost measures. During a 3-month period, 217 women aged 18 to 30 years enrolled; 67% returned the kit. Of these, 92% viewed their results online. STI prevalence was 5.6% (chlamydia and trichomoniasis). All participants with STIs received treatment either the same day at a pharmacy (62%) or within 7 days at a clinic (38%). Among participants completing follow-up surveys, 99% would recommend the online eSTI system to a friend, and 95% preferred it over clinic-based testing within a study. The fully integrated eSTI system has the potential to increase diagnosis and treatment of STIs with higher patient satisfaction at a potentially lower cost.

A Fully Integrated Quartz MEMS VHF TCXO.

PubMed

Kubena, Randall L; Stratton, Frederic P; Nguyen, Hung D; Kirby, Deborah J; Chang, David T; Joyce, Richard J; Yong, Yook-Kong; Garstecki, Jeffrey F; Cross, Matthew D; Seman, S E

2018-06-01

We report on a 32-MHz quartz temperature compensated crystal oscillator (TCXO) fully integrated with commercial CMOS electronics and vacuum packaged at wafer level using a low-temperature MEMS-after quartz process. The novel quartz resonator design provides for stress isolation from the CMOS substrate, thereby yielding classical AT-cut f/T profiles and low hysteresis which can be compensated to < ±0.2 parts per million over temperature using on-chip third-order compensation circuitry. The TCXO operates at low power of 2.5 mW and can be thinned to as part of the wafer-level eutectic encapsulation. Full integration with large state-of-the-art CMOS wafers is possible using carrier wafer techniques.

Three Course Connections: Integrated Event Design

ERIC Educational Resources Information Center

Johnson, Corey W.; Pate, Joseph A.

2013-01-01

Integrated Event Design (IED) capitalizes on three distinct courses to achieve a blended course delivery: Event Management, Research and Evaluation (for undergraduate students), and Experiential Education (for graduate students). Through the use of an event management company metaphor that fully integrates the diverse curricular concepts, course…

Fully-coupled analysis of jet mixing problems. Part 1. Shock-capturing model, SCIPVIS

NASA Technical Reports Server (NTRS)

Dash, S. M.; Wolf, D. E.

1984-01-01

A computational model, SCIPVIS, is described which predicts the multiple cell shock structure in imperfectly expanded, turbulent, axisymmetric jets. The model spatially integrates the parabolized Navier-Stokes jet mixing equations using a shock-capturing approach in supersonic flow regions and a pressure-split approximation in subsonic flow regions. The regions are coupled using a viscous-characteristic procedure. Turbulence processes are represented via the solution of compressibility-corrected two-equation turbulence models. The formation of Mach discs in the jet and the interactive analysis of the wake-like mixing process occurring behind Mach discs is handled in a rigorous manner. Calculations are presented exhibiting the fundamental interactive processes occurring in supersonic jets and the model is assessed via comparisons with detailed laboratory data for a variety of under- and overexpanded jets.

An anisotropic thermomechanical damage model for concrete at transient elevated temperatures.

PubMed

Baker, Graham; de Borst, René

2005-11-15

The behaviour of concrete at elevated temperatures is important for an assessment of integrity (strength and durability) of structures exposed to a high-temperature environment, in applications such as fire exposure, smelting plants and nuclear installations. In modelling terms, a coupled thermomechanical analysis represents a generalization of the computational mechanics of fracture and damage. Here, we develop a fully coupled anisotropic thermomechanical damage model for concrete under high stress and transient temperature, with emphasis on the adherence of the model to the laws of thermodynamics. Specific analytical results are given, deduced from thermodynamics, of a novel interpretation on specific heat, evolution of entropy and the identification of the complete anisotropic, thermomechanical damage surface. The model is also shown to be stable in a computational sense, and to satisfy the laws of thermodynamics.

ATGC transcriptomics: a web-based application to integrate, explore and analyze de novo transcriptomic data.

PubMed

Gonzalez, Sergio; Clavijo, Bernardo; Rivarola, Máximo; Moreno, Patricio; Fernandez, Paula; Dopazo, Joaquín; Paniego, Norma

2017-02-22

In the last years, applications based on massively parallelized RNA sequencing (RNA-seq) have become valuable approaches for studying non-model species, e.g., without a fully sequenced genome. RNA-seq is a useful tool for detecting novel transcripts and genetic variations and for evaluating differential gene expression by digital measurements. The large and complex datasets resulting from functional genomic experiments represent a challenge in data processing, management, and analysis. This problem is especially significant for small research groups working with non-model species. We developed a web-based application, called ATGC transcriptomics, with a flexible and adaptable interface that allows users to work with new generation sequencing (NGS) transcriptomic analysis results using an ontology-driven database. This new application simplifies data exploration, visualization, and integration for a better comprehension of the results. ATGC transcriptomics provides access to non-expert computer users and small research groups to a scalable storage option and simple data integration, including database administration and management. The software is freely available under the terms of GNU public license at http://atgcinta.sourceforge.net .

Evolutionary perspectives on emotions and their link to intentions, dispositions and behavior. Comment on "The quartet theory of human emotions: An integrative and neurofunctional model" by S. Koelsch et al.

NASA Astrophysics Data System (ADS)

Wildgruber, Dirk; Kreifelts, Benjamin

2015-06-01

Koelsch and coworkers present a sophisticated neuroanatomical model of emotions comprising four affect-systems and four output-systems, each bound to a specific brain area [1]. Moreover, they suggest the emergence of distinct components of subjective feelings or "emotion percepts" due to integration of the activation across these subsystems. Incorporating numerous neurobiological, psychological and philosophical findings on human emotions, the model reflects an extensive interdisciplinary approach. Considering an evolutionary perspective, however, we would like to address some issues concerning emotions and their link to intentions, dispositions and behavior that are not fully covered by the Quartet Model. Charles Darwin pointed out that individuals that are better adapted to their environment have increased chances of survival and reproduction. Therefore, natural selection leads to a rising prevalence of properties offering a survival benefit across generations [2]. To better understand the biological functions of emotions we propose to ask the question: How do emotions provide a benefit for survival and reproduction?

Data integration for inference about spatial processes: A model-based approach to test and account for data inconsistency

PubMed Central

Pedrini, Paolo; Bragalanti, Natalia; Groff, Claudio

2017-01-01

Recently-developed methods that integrate multiple data sources arising from the same ecological processes have typically utilized structured data from well-defined sampling protocols (e.g., capture-recapture and telemetry). Despite this new methodological focus, the value of opportunistic data for improving inference about spatial ecological processes is unclear and, perhaps more importantly, no procedures are available to formally test whether parameter estimates are consistent across data sources and whether they are suitable for integration. Using data collected on the reintroduced brown bear population in the Italian Alps, a population of conservation importance, we combined data from three sources: traditional spatial capture-recapture data, telemetry data, and opportunistic data. We developed a fully integrated spatial capture-recapture (SCR) model that included a model-based test for data consistency to first compare model estimates using different combinations of data, and then, by acknowledging data-type differences, evaluate parameter consistency. We demonstrate that opportunistic data lend itself naturally to integration within the SCR framework and highlight the value of opportunistic data for improving inference about space use and population size. This is particularly relevant in studies of rare or elusive species, where the number of spatial encounters is usually small and where additional observations are of high value. In addition, our results highlight the importance of testing and accounting for inconsistencies in spatial information from structured and unstructured data so as to avoid the risk of spurious or averaged estimates of space use and consequently, of population size. Our work supports the use of a single modeling framework to combine spatially-referenced data while also accounting for parameter consistency. PMID:28973034

Scale effect challenges in urban hydrology highlighted with a Fully Distributed Model and High-resolution rainfall data

NASA Astrophysics Data System (ADS)

Ichiba, Abdellah; Gires, Auguste; Tchiguirinskaia, Ioulia; Schertzer, Daniel; Bompard, Philippe; Ten Veldhuis, Marie-Claire

2017-04-01

Nowadays, there is a growing interest on small-scale rainfall information, provided by weather radars, to be used in urban water management and decision-making. Therefore, an increasing interest is in parallel devoted to the development of fully distributed and grid-based models following the increase of computation capabilities, the availability of high-resolution GIS information needed for such models implementation. However, the choice of an appropriate implementation scale to integrate the catchment heterogeneity and the whole measured rainfall variability provided by High-resolution radar technologies still issues. This work proposes a two steps investigation of scale effects in urban hydrology and its effects on modeling works. In the first step fractal tools are used to highlight the scale dependency observed within distributed data used to describe the catchment heterogeneity, both the structure of the sewer network and the distribution of impervious areas are analyzed. Then an intensive multi-scale modeling work is carried out to understand scaling effects on hydrological model performance. Investigations were conducted using a fully distributed and physically based model, Multi-Hydro, developed at Ecole des Ponts ParisTech. The model was implemented at 17 spatial resolutions ranging from 100 m to 5 m and modeling investigations were performed using both rain gauge rainfall information as well as high resolution X band radar data in order to assess the sensitivity of the model to small scale rainfall variability. Results coming out from this work demonstrate scale effect challenges in urban hydrology modeling. In fact, fractal concept highlights the scale dependency observed within distributed data used to implement hydrological models. Patterns of geophysical data change when we change the observation pixel size. The multi-scale modeling investigation performed with Multi-Hydro model at 17 spatial resolutions confirms scaling effect on hydrological model performance. Results were analyzed at three ranges of scales identified in the fractal analysis and confirmed in the modeling work. The sensitivity of the model to small-scale rainfall variability was discussed as well.

Prediction and Informative Risk Factor Selection of Bone Diseases.

PubMed

Li, Hui; Li, Xiaoyi; Ramanathan, Murali; Zhang, Aidong

2015-01-01

With the booming of healthcare industry and the overwhelming amount of electronic health records (EHRs) shared by healthcare institutions and practitioners, we take advantage of EHR data to develop an effective disease risk management model that not only models the progression of the disease, but also predicts the risk of the disease for early disease control or prevention. Existing models for answering these questions usually fall into two categories: the expert knowledge based model or the handcrafted feature set based model. To fully utilize the whole EHR data, we will build a framework to construct an integrated representation of features from all available risk factors in the EHR data and use these integrated features to effectively predict osteoporosis and bone fractures. We will also develop a framework for informative risk factor selection of bone diseases. A pair of models for two contrast cohorts (e.g., diseased patients versus non-diseased patients) will be established to discriminate their characteristics and find the most informative risk factors. Several empirical results on a real bone disease data set show that the proposed framework can successfully predict bone diseases and select informative risk factors that are beneficial and useful to guide clinical decisions.

Science based integrated approach to advanced nuclear fuel development - integrated multi-scale multi-physics hierarchical modeling and simulation framework Part III: cladding

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tome, Carlos N; Caro, J A; Lebensohn, R A

2010-01-01

Advancing the performance of Light Water Reactors, Advanced Nuclear Fuel Cycles, and Advanced Reactors, such as the Next Generation Nuclear Power Plants, requires enhancing our fundamental understanding of fuel and materials behavior under irradiation. The capability to accurately model the nuclear fuel systems to develop predictive tools is critical. Not only are fabrication and performance models needed to understand specific aspects of the nuclear fuel, fully coupled fuel simulation codes are required to achieve licensing of specific nuclear fuel designs for operation. The backbone of these codes, models, and simulations is a fundamental understanding and predictive capability for simulating themore » phase and microstructural behavior of the nuclear fuel system materials and matrices. In this paper we review the current status of the advanced modeling and simulation of nuclear reactor cladding, with emphasis on what is available and what is to be developed in each scale of the project, how we propose to pass information from one scale to the next, and what experimental information is required for benchmarking and advancing the modeling at each scale level.« less

Image reconstruction and system modeling techniques for virtual-pinhole PET insert systems

PubMed Central

Keesing, Daniel B; Mathews, Aswin; Komarov, Sergey; Wu, Heyu; Song, Tae Yong; O'Sullivan, Joseph A; Tai, Yuan-Chuan

2012-01-01

Virtual-pinhole PET (VP-PET) imaging is a new technology in which one or more high-resolution detector modules are integrated into a conventional PET scanner with lower-resolution detectors. It can locally enhance the spatial resolution and contrast recovery near the add-on detectors, and depending on the configuration, may also increase the sensitivity of the system. This novel scanner geometry makes the reconstruction problem more challenging compared to the reconstruction of data from a standalone PET scanner, as new techniques are needed to model and account for the non-standard acquisition. In this paper, we present a general framework for fully 3D modeling of an arbitrary VP-PET insert system. The model components are incorporated into a statistical reconstruction algorithm to estimate an image from the multi-resolution data. For validation, we apply the proposed model and reconstruction approach to one of our custom-built VP-PET systems – a half-ring insert device integrated into a clinical PET/CT scanner. Details regarding the most important implementation issues are provided. We show that the proposed data model is consistent with the measured data, and that our approach can lead to reconstructions with improved spatial resolution and lesion detectability. PMID:22490983

The exploration and practice of integrated innovation teaching mode in the Applied Optics course

NASA Astrophysics Data System (ADS)

Liu, Dongmei; Zhao, Huifu; Fu, Xiuhua; Zhang, Jing

2017-08-01

In recent years, the Ministry of Education of China attaches great importance to the reform of higher education quality. As an important link in the reform of higher education, curriculum development is bound to promote the development of "quality-centered connotative education". Zhejiang University, Changchun University of Science and Technology, Southern Airlines University and other colleges and universities carried out a full range of close cooperation, proposed integrated innovation teaching mode of the course based on network technology. Based on this model, the course of "Applied Optics" has been practiced for two years. The results show that the integrated innovation teaching mode can fully realize the integration amplification effect among multiple colleges and universities and the depth sharing all types of resources. Based on the principle of co-building and sharing, mutual help, comprehensively improve the teaching quality of domestic related courses and promote the comprehensive development of the curriculum to meet the needs of learning society.

Integrated management of major depression for people with cancer.

PubMed

Walker, Jane; Sharpe, Michael

2014-12-01

Major depression is an important complication of cancer. However, it is frequently inadequately treated. There are challenges both in identifying which cancer patients are depressed, and in ensuring that these patients receive effective treatment for their depression. Integration of depression management into cancer care has been advocated as a way to address these challenges. Such integrated approaches must include both the systematic identification of cases and the delivery of treatment. We describe here a system of depression care that includes both a screening programme to identify patients with depression and a linked treatment programme, based on the collaborative care model, called 'Depression Care for People with Cancer' (DCPC). The system of care was designed to be fully integrated with specialist cancer services and has been robustly evaluated in randomized trials. We describe how the system operates and explain why it is designed as it is. We also summarize the evidence for its effectiveness and cost-effectiveness and discuss its implementation in routine clinical practice.

Integrative and distinctive coding of visual and conceptual object features in the ventral visual stream

PubMed Central

Douglas, Danielle; Newsome, Rachel N; Man, Louisa LY

2018-01-01

A significant body of research in cognitive neuroscience is aimed at understanding how object concepts are represented in the human brain. However, it remains unknown whether and where the visual and abstract conceptual features that define an object concept are integrated. We addressed this issue by comparing the neural pattern similarities among object-evoked fMRI responses with behavior-based models that independently captured the visual and conceptual similarities among these stimuli. Our results revealed evidence for distinctive coding of visual features in lateral occipital cortex, and conceptual features in the temporal pole and parahippocampal cortex. By contrast, we found evidence for integrative coding of visual and conceptual object features in perirhinal cortex. The neuroanatomical specificity of this effect was highlighted by results from a searchlight analysis. Taken together, our findings suggest that perirhinal cortex uniquely supports the representation of fully specified object concepts through the integration of their visual and conceptual features. PMID:29393853

Energy saving by using asymmetric aftbodies for merchant ships-design methodology, numerical simulation and validation

NASA Astrophysics Data System (ADS)

Dang, Jie; Chen, Hao

2016-12-01

The methodology and procedures are discussed on designing merchant ships to achieve fully-integrated and optimized hull-propulsion systems by using asymmetric aftbodies. Computational fluid dynamics (CFD) has been used to evaluate the powering performance through massive calculations with automatic deformation algorisms for the hull forms and the propeller blades. Comparative model tests of the designs to the optimized symmetric hull forms have been carried out to verify the efficiency gain. More than 6% improvement on the propulsive efficiency of an oil tanker has been measured during the model tests. Dedicated sea-trials show good agreement with the predicted performance from the test results.

The quantization of the chiral Schwinger model based on the BFT-BFV formalism II

NASA Astrophysics Data System (ADS)

Park, Mu-In; Park, Young-Jai; Yoon, Sean J.

1998-12-01

We apply an improved version of Batalin-Fradkin-Tyutin Hamiltonian method to the a = 1 chiral Schwinger model, which is much more nontrivial than the a>1 one. Furthermore, through the path integral quantization, we newly resolve the problem of the nontrivial 0954-3899/24/12/002/img6-function as well as that of the unwanted Fourier parameter 0954-3899/24/12/002/img7 in the measure. As a result, we explicitly obtain the fully gauge invariant partition function, which includes a new type of Wess-Zumino term irrelevant to the gauge symmetry as well as the usual WZ action.

A cooperative game theory approach to transmission planning in power systems

NASA Astrophysics Data System (ADS)

Contreras, Javier

The rapid restructuring of the electric power industry from a vertically integrated entity into a decentralized industry has given rise to complex problems. In particular, the transmission component of the electric power system requires new methodologies to fully capture this emerging competitive industry. Game theory models are used to model strategic interactions in a competitive environment. This thesis presents a new decentralized framework to study the transmission network expansion problem using cooperative game theory. First, the players and the rules of the game are defined. Second, a coalition formation scheme is developed. Finally, the optimized cost of expansion is allocated based on the history of the coalition formation.

Astronomical Simulations Using Visual Python

NASA Astrophysics Data System (ADS)

Cobb, Michael L.

2007-05-01

The Physics and Engineering Physics Department at Southeast Missouri State University has adopted the “Matter and Interactions I Modern Mechanics” text by Chabay and Sherwood for our calculus based introductory physics course. We have fully integrated the use of modeling and simulations by using the Visual Python language also know as VPython. This powerful, high level, object orientated language with full three dimensional, stereo graphics has stimulated both my students and myself to find wider applications for our new found skills. We have successfully modeled gravitational resonances in planetary rings, galaxy collisions, and planetary orbits around binary star systems. This talk will provide a quick overview of VPython and demonstrate the various simulations.

Status of NASA/Army rotorcraft research and development piloted flight simulation

NASA Technical Reports Server (NTRS)

Condon, Gregory W.; Gossett, Terrence D.

1988-01-01

The status of the major NASA/Army capabilities in piloted rotorcraft flight simulation is reviewed. The requirements for research and development piloted simulation are addressed as well as the capabilities and technologies that are currently available or are being developed by NASA and the Army at Ames. The application of revolutionary advances (in visual scene, electronic cockpits, motion, and modelling of interactive mission environments and/or vehicle systems) to the NASA/Army facilities are also addressed. Particular attention is devoted to the major advances made in integrating these individual capabilities into fully integrated simulation environment that were or are being applied to new rotorcraft mission requirements. The specific simulators discussed are the Vertical Motion Simulator and the Crew Station Research and Development Facility.

Broadband microwave photonic fully tunable filter using a single heterogeneously integrated III-V/SOI-microdisk-based phase shifter.

PubMed

Lloret, Juan; Morthier, Geert; Ramos, Francisco; Sales, Salvador; Van Thourhout, Dries; Spuesens, Thijs; Olivier, Nicolas; Fédéli, Jean-Marc; Capmany, José

2012-05-07

A broadband microwave photonic phase shifter based on a single III-V microdisk resonator heterogeneously integrated on and coupled to a nanophotonic silicon-on-insulator waveguide is reported. The phase shift tunability is accomplished by modifying the effective index through carrier injection. A comprehensive semi-analytical model aiming at predicting its behavior is formulated and confirmed by measurements. Quasi-linear and continuously tunable 2π phase shifts at radiofrequencies greater than 18 GHz are experimentally demonstrated. The phase shifter performance is also evaluated when used as a key element in tunable filtering schemes. Distortion-free and wideband filtering responses with a tuning range of ~100% over the free spectral range are obtained.

Analysis of renewable energy sources and electric vehicle penetration into energy systems predominantly based on lignite

NASA Astrophysics Data System (ADS)

Dedinec, A.; Jovanovski, B.; Gajduk, A.; Markovska, N.; Kocarev, L.

2016-05-01

We consider an integration of renewable energy into transport and electricity sectors through vehicle to grid (V2G) technologies for an energy system that is predominantly based on lignite. The national energy system of Macedonia is modeled using EnergyPLAN which integrates energy for electricity, transport and heat, and includes hourly fluctuations in human needs and the environment. We show that electric-vehicles can provide the necessary storage enabling a fully renewable energy profile for Macedonia that can match the country's growing demand for energy. Furthermore, a large penetration of electric vehicles leads to a dramatic reduction of 47% of small particles and other air pollutants generated by car traffic in 2050.

Real-time micro-modelling of city evacuations

NASA Astrophysics Data System (ADS)

Löhner, Rainald; Haug, Eberhard; Zinggerling, Claudio; Oñate, Eugenio

2018-01-01

A methodology to integrate geographical information system (GIS) data with large-scale pedestrian simulations has been developed. Advances in automatic data acquisition and archiving from GIS databases, automatic input for pedestrian simulations, as well as scalable pedestrian simulation tools have made it possible to simulate pedestrians at the individual level for complete cities in real time. An example that simulates the evacuation of the city of Barcelona demonstrates that this is now possible. This is the first step towards a fully integrated crowd prediction and management tool that takes into account not only data gathered in real time from cameras, cell phones or other sensors, but also merges these with advanced simulation tools to predict the future state of the crowd.

A taxonomy of integral reaction path analysis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Grcar, Joseph F.; Day, Marcus S.; Bell, John B.

2004-12-23

W. C. Gardiner observed that achieving understanding through combustion modeling is limited by the ability to recognize the implications of what has been computed and to draw conclusions about the elementary steps underlying the reaction mechanism. This difficulty can be overcome in part by making better use of reaction path analysis in the context of multidimensional flame simulations. Following a survey of current practice, an integral reaction flux is formulated in terms of conserved scalars that can be calculated in a fully automated way. Conditional analyses are then introduced, and a taxonomy for bidirectional path analysis is explored. Many examplesmore » illustrate the resulting path analysis and uncover some new results about nonpremixed methane-air laminar jets.« less

Novel, Integrated Reactor / Power Conversion System (LMR-AMTEC)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pablo Rubiolo, Principal Investigator

2003-03-21

The main features of this project were the development of a long life (up to 10 years) Liquid Metal Reactor (LMR) and a static conversion subsystem comprising an Alkali Metal Thermal-to-Electric (AMTEC) topping cycle and a ThermoElectric (TE) Bottom cycle. Various coupling options of the LMR with the energy conversion subsystem were explored and, base in the performances found in this analysis, an Indirect Coupling (IC) between the LMR and the AMTEC/TE converters with Alkali Metal Boilers (AMB) was chosen as the reference design. The performance model of the fully integrated sodium-and potassium-AMTEC/TE converters shows that a combined conversion efficiencymore » in excess of 30% could be achieved by the plant. (B204)« less

Integrated analysis of large space systems

NASA Technical Reports Server (NTRS)

Young, J. P.

1980-01-01

Based on the belief that actual flight hardware development of large space systems will necessitate a formalized method of integrating the various engineering discipline analyses, an efficient highly user oriented software system capable of performing interdisciplinary design analyses with tolerable solution turnaround time is planned Specific analysis capability goals were set forth with initial emphasis given to sequential and quasi-static thermal/structural analysis and fully coupled structural/control system analysis. Subsequently, the IAC would be expanded to include a fully coupled thermal/structural/control system, electromagnetic radiation, and optical performance analyses.

Integrated bio-photonics to revolutionize health care enabled through PIX4life and PIXAPP

NASA Astrophysics Data System (ADS)

Jans, Hilde; O'Brien, Peter; Artundo, Iñigo; Porcel, Marco A. G.; Hoofman, Romano; Geuzebroek, Douwe; Dumon, Pieter; van der Vliet, Marcel; Witzens, Jeremy; Bourguignon, Eric; Van Dorpe, Pol; Lagae, Liesbet

2018-02-01

Photonics has become critical to life sciences. However, the field is far from benefiting fully from photonics' capabilities. Today, bulky and expensive optical systems dominate biomedical photonics, even though robust optical functionality can be realized cost-effectively on single photonic integrated circuits (PICs). Such chips are commercially available mostly for telecom applications, and at infrared wavelengths. Although proof-of-concept demonstrations for PICs in life sciences, using visible wavelengths are abundant, the gating factor for wider adoption is limited in resource capacity. Two European pilot lines, PIX4life and PIXAPP, were established to facilitate European R and D in biophotonics, by helping European companies and universities bridge the gap between research and industrial development. Through creation of an open-access model, PIX4life aims to lower barriers to entry for prototyping and validating biophotonics concepts for larger scale production. In addition, PIXAPP enables the assembly and packaging of photonic integrated circuits.

The crack problem in a reinforced cylindrical shell

NASA Technical Reports Server (NTRS)

Yahsi, O. S.; Erdogan, F.

1986-01-01

In this paper a partially reinforced cylinder containing an axial through crack is considered. The reinforcement is assumed to be fully bonded to the main cylinder. The composite cylinder is thus modelled by a nonhomogeneous shell having a step change in the elastic properties at the z=0 plane, z being the axial coordinate. Using a Reissner type transverse shear theory the problem is reduced to a pair of singular integral equations. In the special case of a crack tip touching the bimaterial interface it is shown that the dominant parts of the kernels of the integral equations associated with both membrane loading and bending of the shell reduce to the generalized Cauchy kernel obtained for the corresponding plane stress case. The integral equations are solved and the stress intensity factors are given for various crack and shell dimensions. A bonded fiberglass reinforcement which may serve as a crack arrestor is used as an example.

The crack problem in a reinforced cylindrical shell

NASA Technical Reports Server (NTRS)

Yahsi, O. S.; Erdogan, F.

1986-01-01

A partially reinforced cylinder containing an axial through crack is considered. The reinforcement is assumed to be fully bonded to the main cylinder. The composite cylinder is thus modelled by a nonhomogeneous shell having a step change in the elastic properties at the z = 0 plane, z being the axial coordinate. Using a Reissner type transverse shear theory the problem is reduced to a pair of singular integral equations. In the special case of a crack tip touching the bimaterial interface it is shown that the dominant parts of the kernels of the integral equations associated with both membrane loading and bending of the shell reduce to the generalized Cauchy kernel obtained for the corresponding plane stress case. The integral equations are solved and the stress intensity factors are given for various crack and shell dimensions. A bonded fiberglass reinforcement which may serve as a crack arrestor is used as an example.

Nonlinear characterization of a silicon integrated Bragg waveguide filter.

PubMed

Massara, Micol Previde; Menotti, Matteo; Bergamasco, Nicola; Harris, Nicholas C; Baehr-Jones, Tom; Hochberg, Michael; Galland, Christophe; Liscidini, Marco; Galli, Matteo; Bajoni, Daniele

2018-03-01

Bragg waveguides are promising optical filters for pump suppression in spontaneous four-wave mixing (FWM) photon sources. In this work, we investigate the generation of unwanted photon pairs in the filter itself. We do this by taking advantage of the relation between spontaneous and classical FWM, which allows for the precise characterization of the nonlinear response of the device. The pair generation rate estimated from the classical measurement is compared with the theoretical value calculated by means of a full quantum model of the filter, which also allows investigation of the spectral properties of the generated pairs. We find a good agreement between theory and experiment, confirming that stimulated FWM is a valuable approach to characterize the nonlinear response of an integrated filter, and that the pairs generated in a Bragg waveguide are not a serious issue for the operation of a fully integrated nonclassical source.

A proactive system for maritime environment monitoring.

PubMed

Moroni, Davide; Pieri, Gabriele; Tampucci, Marco; Salvetti, Ovidio

2016-01-30

The ability to remotely detect and monitor oil spills is becoming increasingly important due to the high demand of oil-based products. Indeed, shipping routes are becoming very crowded and the likelihood of oil slick occurrence is increasing. In this frame, a fully integrated remote sensing system can be a valuable monitoring tool. We propose an integrated and interoperable system able to monitor ship traffic and marine operators, using sensing capabilities from a variety of electronic sensors, along with geo-positioning tools, and through a communication infrastructure. Our system is capable of transferring heterogeneous data, freely and seamlessly, between different elements of the information system (and their users) in a consistent and usable form. The system also integrates a collection of decision support services providing proactive functionalities. Such services demonstrate the potentiality of the system in facilitating dynamic links among different data, models and actors, as indicated by the performed field tests. Copyright © 2015 Elsevier Ltd. All rights reserved.

Using an Integrated Hydrologic Model to Assess the Ecohydrological Impacts of Change on a Mountain Headwaters Critical Zone

NASA Astrophysics Data System (ADS)

Collins, C.; Maxwell, R. M.; Visser, A.

2016-12-01

The critical zone is the region of the Earth's crust where hydrogeology, ecology, and climate interact. As many critical zone processes are fundamental, the significance of studying critical zone processes goes beyond understanding the local ecohydrological setting. Therefore studying critical zone governing processes requires an interdisciplinary approach that integrates simulation and observation. In this study, a high-resolution integrated hydrologic model, ParFlow-CLM, was developed for the Providence Creek watershed. Providence Creek is a highly instrumented critical zone observatory (CZO) located in the southern Sierra Nevada Mountains, a region currently experiencing a range of short-term responses (i.e. tree mortality) to a severe four-year drought. Sources of plant water use, pathways and residence times of water through the subsurface are identified using a suite of isotopic signatures and numerical particle tracking. Implications of using a fully coupled integrated hydrologic model accompanied by tracer analysis include better understanding of water partitioning and water storage in the regolith and vegetation water use during drought time conditions. The importance of subsurface storage, plant available water and lateral flow during the 2012-2015 drought to mitigate vegetation stress are addressed and verified against observed tree mortality. The stream flow response to tree mortality in the aftermath of the drought, analogous to the Colorado Mountain Pine Beetle case, provides insight into the potential effects of proposed forest management practices.

Integration of Irma tactical scene generator into directed-energy weapon system simulation

NASA Astrophysics Data System (ADS)

Owens, Monte A.; Cole, Madison B., III; Laine, Mark R.

2003-08-01

Integrated high-fidelity physics-based simulations that include engagement models, image generation, electro-optical hardware models and control system algorithms have previously been developed by Boeing-SVS for various tracking and pointing systems. These simulations, however, had always used images with featureless or random backgrounds and simple target geometries. With the requirement to engage tactical ground targets in the presence of cluttered backgrounds, a new type of scene generation tool was required to fully evaluate system performance in this challenging environment. To answer this need, Irma was integrated into the existing suite of Boeing-SVS simulation tools, allowing scene generation capabilities with unprecedented realism. Irma is a US Air Force research tool used for high-resolution rendering and prediction of target and background signatures. The MATLAB/Simulink-based simulation achieves closed-loop tracking by running track algorithms on the Irma-generated images, processing the track errors through optical control algorithms, and moving simulated electro-optical elements. The geometry of these elements determines the sensor orientation with respect to the Irma database containing the three-dimensional background and target models. This orientation is dynamically passed to Irma through a Simulink S-function to generate the next image. This integrated simulation provides a test-bed for development and evaluation of tracking and control algorithms against representative images including complex background environments and realistic targets calibrated using field measurements.

An Integrated Approach to Modeling Solar Electric Propulsion Vehicles During Long Duration, Near-Earth Orbit Transfers

NASA Technical Reports Server (NTRS)

Smith, David A.; Hojnicki, Jeffrey S.; Sjauw, Waldy K.

2014-01-01

Recent NASA interest in utilizing solar electronic propulsion (SEP) technology to transfer payloads, e.g. from low-Earth orbit (LEO) to higher energy geostationary-Earth orbit (GEO) or to Earth escape, has necessitated the development of high fidelity SEP vehicle models and simulations. These models and simulations need to be capable of capturing vehicle dynamics and sub-system interactions experienced during the transfer trajectories which are typically accomplished with continuous-burn (potentially interrupted by solar eclipse), long duration "spiral out" maneuvers taking several months or more to complete. This paper presents details of an integrated simulation approach achieved by combining a high fidelity vehicle simulation code with a detailed solar array model. The combined simulation tool gives researchers the functionality to study the integrated effects of various vehicle sub-systems (e.g. vehicle guidance, navigation and control (GN&C), electric propulsion system (EP)) with time varying power production. Results from a simulation model of a vehicle with a 50 kW class SEP system using the integrated tool are presented and compared to the results from another simulation model employing a 50 kW end-of-life (EOL) fixed power level assumption. These models simulate a vehicle under three degree of freedom dynamics (i.e. translational dynamics only) and include the effects of a targeting guidance algorithm (providing a "near optimal" transfer) during a LEO to near Earth escape (C (sub 3) = -2.0 km (sup 2) / sec (sup -2) spiral trajectory. The presented results include the impact of the fully integrated, time-varying solar array model (e.g. cumulative array degradation from traversing the Van Allen belts, impact of solar eclipses on the vehicle and the related temperature responses in the solar arrays due to operating in the Earth's thermal environment, high fidelity array power module, etc.); these are used to assess the impact on vehicle performance (i.e. propellant consumption) and transit times.

Modeling the Buildup of Annular Pressure in Cased and Uncased Annuli of Faulty Wellbores

NASA Astrophysics Data System (ADS)

Lackey, G.; Rajaram, H.

2017-12-01

Structurally sound wellbores are essential to oil and gas production, natural gas storage, and carbon dioxide sequestration operations. Wellbore integrity is easily assessed at the wellhead by the presence of pressure or gas flow in the outer annuli of a well, as it indicates the uncontrolled vertical migration of fluids outside the production casing. This phenomenon is typically referred to as sustained casing pressure (SCP), sustained annular pressure, or surface casing vent flow. Of particular concern is the buildup of pressure in the surface casing annulus. If the surface casing is sealed at the wellhead and cement is not brought into the bottom of the casing, annular pressure that builds induces gas migration when the fluid and entry pressure of the formation at the bottom of the surface casing is exceeded. Multiple incidents of stray gas migration from oil and gas operations have contaminated water wells in Colorado, Pennsylvania, and Ohio through this mechanism. Natural gas escaping the #25 Standard Senson well at the Aliso Gas storage facility in California, the largest accidental release of greenhouse gases in US history, also followed this pathway. Previous studies have modeled the buildup of SCP in faulty wells with fully-cased annuli that are isolated from the surrounding formation. However, the majority of onshore oil and gas wells in the US are constructed with uncased outermost annuli that are hydraulically connected to the surrounding subsurface. In this study, we adapt current approaches of modeling SCP to include the regulation of annular liquid level by formation fluid pressure, dissolution of gas into the annular liquids, the transport of aqueous gas by crossflow into deep formations, and gas migration away from the well, when the entry pressure of the formations or fractures along the uncased annulus is exceeded, to compare the buildup behavior of SCP in both uncased and fully-cased annuli. We consider well construction and subsurface geology representative of the Wattenberg Field in Colorado and interpret observations of sustained casing pressure collected by the Colorado Oil and Gas Conservation Commission. We demonstrate that the potential negative consequences of integrity loss are much greater for an uncased well than for fully-cased well.

Water resources sensitivity to the isolated effects of land use, water demand and climate change under 2 degree global warming

NASA Astrophysics Data System (ADS)

Bisselink, Berny; Bernhard, Jeroen; de Roo, Ad

2017-04-01

One of the key impacts of global change are the future water resources. These water resources are influenced by changes in land use (LU), water demand (WD) and climate change. Recent developments in scenario modelling opened new opportunities for an integrated assessment. However, for identifying water resource management strategies it is helpful to focus on the isolated effects of possible changes in LU, WD and climate that may occur in the near future. In this work, we quantify the isolated contribution of LU, WD and climate to the integrated total water resources assuming a linear model behavior. An ensemble of five EURO-CORDEX RCP8.5 climate projections for the 31-year periods centered on the year of exceeding the global-mean temperature of 2 degree is used to drive the fully distributed hydrological model LISFLOOD for multiple river catchments in Europe. The JRC's Land Use Modelling Platform LUISA was used to obtain a detailed pan-European reference land use scenario until 2050. Water demand is estimated based on socio-economic (GDP, population estimates etc.), land use and climate projections as well. For each climate projection, four model runs have been performed including an integrated (LU, WD and climate) simulation and other three simulations to isolate the effect of LU, WD and climate. Changes relative to the baseline in terms of water resources indicators of the ensemble means of the 2 degree warming period and their associated uncertainties will reveal the integrated and isolated effect of LU, WD and climate change on water resources.

European vegetation during Marine Oxygen Isotope Stage-3

NASA Astrophysics Data System (ADS)

Huntley, Brian; Alfano, Mary J. o.; Allen, Judy R. M.; Pollard, Dave; Tzedakis, Polychronis C.; de Beaulieu, Jacques-Louis; Grüger, Eberhard; Watts, Bill

2003-03-01

European vegetation during representative "warm" and "cold" intervals of stage-3 was inferred from pollen analytical data. The inferred vegetation differs in character and spatial pattern from that of both fully glacial and fully interglacial conditions and exhibits contrasts between warm and cold intervals, consistent with other evidence for stage-3 palaeoenvironmental fluctuations. European vegetation thus appears to have been an integral component of millennial environmental fluctuations during stage-3; vegetation responded to this scale of environmental change and through feedback mechanisms may have had effects upon the environment. The pollen-inferred vegetation was compared with vegetation simulated using the BIOME 3.5 vegetation model for climatic conditions simulated using a regional climate model (RegCM2) nested within a coupled global climate and vegetation model (GENESIS-BIOME). Despite some discrepancies in detail, both approaches capture the principal features of the present vegetation of Europe. The simulated vegetation for stage-3 differs markedly from that inferred from pollen analytical data, implying substantial discrepancy between the simulated climate and that actually prevailing. Sensitivity analyses indicate that the simulated climate is too warm and probably has too short a winter season. These discrepancies may reflect incorrect specification of sea surface temperature or sea-ice conditions and may be exacerbated by vegetation-climate feedback in the coupled global model.

Fully implicit adaptive mesh refinement algorithm for reduced MHD

NASA Astrophysics Data System (ADS)

Philip, Bobby; Pernice, Michael; Chacon, Luis

2006-10-01

In the macroscopic simulation of plasmas, the numerical modeler is faced with the challenge of dealing with multiple time and length scales. Traditional approaches based on explicit time integration techniques and fixed meshes are not suitable for this challenge, as such approaches prevent the modeler from using realistic plasma parameters to keep the computation feasible. We propose here a novel approach, based on implicit methods and structured adaptive mesh refinement (SAMR). Our emphasis is on both accuracy and scalability with the number of degrees of freedom. As a proof-of-principle, we focus on the reduced resistive MHD model as a basic MHD model paradigm, which is truly multiscale. The approach taken here is to adapt mature physics-based technology to AMR grids, and employ AMR-aware multilevel techniques (such as fast adaptive composite grid --FAC-- algorithms) for scalability. We demonstrate that the concept is indeed feasible, featuring near-optimal scalability under grid refinement. Results of fully-implicit, dynamically-adaptive AMR simulations in challenging dissipation regimes will be presented on a variety of problems that benefit from this capability, including tearing modes, the island coalescence instability, and the tilt mode instability. L. Chac'on et al., J. Comput. Phys. 178 (1), 15- 36 (2002) B. Philip, M. Pernice, and L. Chac'on, Lecture Notes in Computational Science and Engineering, accepted (2006)

77 FR 59932 - Single Source Award; Exception to Competition

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-01

... Primary Care Integration Project. In fiscal year (FY) 2012, $486,394 will be available to fully fund this..., effectively, and efficiently implement the CHW Behavioral Health Primary Care Integration Project within their... qualified to carry out the CHW Behavioral Health Primary Care Integration Project because of their...

Rejoinder to Guterman, Martin, and Kopp

ERIC Educational Resources Information Center

Hansen, James T.

2012-01-01

In their reply to the author's keystone article (Hansen, 2012), Guterman, Martin, and Kopp (2012) charge that the author's integrative framework was not sufficiently integrative. They also argue that his proposal results in logical contradictions and the mind-body problem. The author responds by noting that his proposal fully integrates the…

Ultramap v3 - a Revolution in Aerial Photogrammetry

NASA Astrophysics Data System (ADS)

Reitinger, B.; Sormann, M.; Zebedin, L.; Schachinger, B.; Hoefler, M.; Tomasi, R.; Lamperter, M.; Gruber, B.; Schiester, G.; Kobald, M.; Unger, M.; Klaus, A.; Bernoegger, S.; Karner, K.; Wiechert, A.; Ponticelli, M.; Gruber, M.

2012-07-01

In the last years, Microsoft has driven innovation in the aerial photogrammetry community. Besides the market leading camera technology, UltraMap has grown to an outstanding photogrammetric workflow system which enables users to effectively work with large digital aerial image blocks in a highly automated way. Best example is the project-based color balancing approach which automatically balances images to a homogeneous block. UltraMap V3 continues innovation, and offers a revolution in terms of ortho processing. A fully automated dense matching module strives for high precision digital surface models (DSMs) which are calculated either on CPUs or on GPUs using a distributed processing framework. By applying constrained filtering algorithms, a digital terrain model can be derived which in turn can be used for fully automated traditional ortho texturing. By having the knowledge about the underlying geometry, seamlines can be generated automatically by applying cost functions in order to minimize visual disturbing artifacts. By exploiting the generated DSM information, a DSMOrtho is created using the balanced input images. Again, seamlines are detected automatically resulting in an automatically balanced ortho mosaic. Interactive block-based radiometric adjustments lead to a high quality ortho product based on UltraCam imagery. UltraMap v3 is the first fully integrated and interactive solution for supporting UltraCam images at best in order to deliver DSM and ortho imagery.

Integrated corridor management (ICM) knowledge and technology transfer (KTT).

DOT National Transportation Integrated Search

2014-01-01

The ICM approach involves aggressive, proactive integration of infrastructure along major corridors so that transportation professionals can fully leverage all existing modal choices and assets. ICM helps transportation leaders improve travel time re...

Numerical study of interfacial solitary waves propagating under an elastic sheet

PubMed Central

Wang, Zhan; Părău, Emilian I.; Milewski, Paul A.; Vanden-Broeck, Jean-Marc

2014-01-01

Steady solitary and generalized solitary waves of a two-fluid problem where the upper layer is under a flexible elastic sheet are considered as a model for internal waves under an ice-covered ocean. The fluid consists of two layers of constant densities, separated by an interface. The elastic sheet resists bending forces and is mathematically described by a fully nonlinear thin shell model. Fully localized solitary waves are computed via a boundary integral method. Progression along the various branches of solutions shows that barotropic (i.e. surface modes) wave-packet solitary wave branches end with the free surface approaching the interface. On the other hand, the limiting configurations of long baroclinic (i.e. internal) solitary waves are characterized by an infinite broadening in the horizontal direction. Baroclinic wave-packet modes also exist for a large range of amplitudes and generalized solitary waves are computed in a case of a long internal mode in resonance with surface modes. In contrast to the pure gravity case (i.e without an elastic cover), these generalized solitary waves exhibit new Wilton-ripple-like periodic trains in the far field. PMID:25104909

Design for and efficient dynamic climate model with realistic geography

NASA Technical Reports Server (NTRS)

Suarez, M. J.; Abeles, J.

1984-01-01

The long term climate sensitivity which include realistic atmospheric dynamics are severely restricted by the expense of integrating atmospheric general circulation models are discussed. Taking as an example models used at GSFC for this dynamic model is an alternative which is of much lower horizontal or vertical resolution. The model of Heid and Suarez uses only two levels in the vertical and, although it has conventional grid resolution in the meridional direction, horizontal resolution is reduced by keeping only a few degrees of freedom in the zonal wavenumber spectrum. Without zonally asymmetric forcing this model simulates a day in roughly 1/2 second on a CRAY. The model under discussion is a fully finite differenced, zonally asymmetric version of the Heid-Suarez model. It is anticipated that speeds can be obtained a few seconds a day roughly 50 times faster than moderate resolution, multilayer GCM's.

Fully Printed Memristors from Cu-SiO2 Core-Shell Nanowire Composites

NASA Astrophysics Data System (ADS)

Catenacci, Matthew J.; Flowers, Patrick F.; Cao, Changyong; Andrews, Joseph B.; Franklin, Aaron D.; Wiley, Benjamin J.

2017-07-01

This article describes a fully printed memory in which a composite of Cu-SiO2 nanowires dispersed in ethylcellulose acts as a resistive switch between printed Cu and Au electrodes. A 16-cell crossbar array of these memristors was printed with an aerosol jet. The memristors exhibited moderate operating voltages (˜3 V), no degradation over 104 switching cycles, write speeds of 3 μs, and extrapolated retention times of 10 years. The low operating voltage enabled the programming of a fully printed 4-bit memristor array with an Arduino. The excellent performance of these fully printed memristors could help enable the creation of fully printed RFID tags and sensors with integrated data storage.

Numerical Approach to Spatial Deterministic-Stochastic Models Arising in Cell Biology.

PubMed

Schaff, James C; Gao, Fei; Li, Ye; Novak, Igor L; Slepchenko, Boris M

2016-12-01

Hybrid deterministic-stochastic methods provide an efficient alternative to a fully stochastic treatment of models which include components with disparate levels of stochasticity. However, general-purpose hybrid solvers for spatially resolved simulations of reaction-diffusion systems are not widely available. Here we describe fundamentals of a general-purpose spatial hybrid method. The method generates realizations of a spatially inhomogeneous hybrid system by appropriately integrating capabilities of a deterministic partial differential equation solver with a popular particle-based stochastic simulator, Smoldyn. Rigorous validation of the algorithm is detailed, using a simple model of calcium 'sparks' as a testbed. The solver is then applied to a deterministic-stochastic model of spontaneous emergence of cell polarity. The approach is general enough to be implemented within biologist-friendly software frameworks such as Virtual Cell.

Modeling and Simulation of Nanoindentation

NASA Astrophysics Data System (ADS)

Huang, Sixie; Zhou, Caizhi

2017-11-01

Nanoindentation is a hardness test method applied to small volumes of material which can provide some unique effects and spark many related research activities. To fully understand the phenomena observed during nanoindentation tests, modeling and simulation methods have been developed to predict the mechanical response of materials during nanoindentation. However, challenges remain with those computational approaches, because of their length scale, predictive capability, and accuracy. This article reviews recent progress and challenges for modeling and simulation of nanoindentation, including an overview of molecular dynamics, the quasicontinuum method, discrete dislocation dynamics, and the crystal plasticity finite element method, and discusses how to integrate multiscale modeling approaches seamlessly with experimental studies to understand the length-scale effects and microstructure evolution during nanoindentation tests, creating a unique opportunity to establish new calibration procedures for the nanoindentation technique.

Integrated treatment options for male perpetrators of intimate partner violence.

PubMed

Crane, Cory A; Easton, Caroline J

2017-01-01

Male-to-female intimate partner violence remains a worldwide public health issue with adverse physical and psychological consequences for victims, perpetrators and children. Personality disorders, addiction, trauma and mood symptoms are established risk factors for intimate partner violence perpetration and factor prominently into a recovery-oriented treatment approach. We reviewed the partner violence literature for detailed reports of traditional as well as innovative, integrated treatment approaches. Empirically based recommendations for intervention programs and the policies that guide intervention efforts are offered. Nascent research suggests that integrated treatment models utilising a holistic approach to account for psychological comorbidity and interventions that involve a motivational interviewing component appear promising in terms of significantly improving intimate partner violence treatment compliance and reducing subsequent acts of physical partner violence. Further, methodologically rigorous research is required to fully assess the benefits of traditional and integrated treatment options. We have advanced several recommendations, including the development of and exclusive reliance upon empirically supported treatments, conducting a thorough risk and needs assessment of the offender and the immediate family to facilitate appropriate treatment referrals, integrating content to foster the offender's internal motivation to change maladaptive behaviours, and attempting to minimise offender treatment burdens through the strategic use of integrated treatment models. Intimate partner violence is a complicated and nuanced problem that is perpetrated by a heterogeneous population and requires greater variability in integrated treatment options. [Crane CA, Easton CJ. Integrated treatment options for male perpetrators of intimate partner violence. Drug Alcohol Rev 2017;36:24-33]. © 2017 Australasian Professional Society on Alcohol and other Drugs.

Bridging Animal and Human Models

PubMed Central

Barkley-Levenson, Amanda M.; Crabbe, John C.

2012-01-01

Genetics play an important role in the development and course of alcohol abuse, and understanding genetic contributions to this disorder may lead to improved preventative and therapeutic strategies in the future. Studies both in humans and in animal models are necessary to fully understand the neurobiology of alcoholism from the molecular to the cognitive level. By dissecting the complex facets of alcoholism into discrete, well-defined phenotypes that are measurable in both human populations and animal models of the disease, researchers will be better able to translate findings across species and integrate the knowledge obtained from various disciplines. Some of the key areas of alcoholism research where consilience between human and animal studies is possible are alcohol withdrawal severity, sensitivity to rewards, impulsivity, and dysregulated alcohol consumption. PMID:23134048

Characterization of Space Shuttle Ascent Debris Aerodynamics Using CFD Methods

NASA Technical Reports Server (NTRS)

Murman, Scott M.; Aftosmis, Michael J.; Rogers, Stuart E.

2005-01-01

An automated Computational Fluid Dynamics process for determining the aerodynamic Characteristics of debris shedding from the Space Shuttle Launch Vehicle during ascent is presented. This process uses Cartesian fully-coupled, six-degree-of-freedom simulations of isolated debris pieces in a Monte Carlo fashion to produce models for the drag and crossrange behavior over a range of debris shapes and shedding scenarios. A validation of the Cartesian methods against ballistic range data for insulating foam debris shapes at flight conditions, as well as validation of the resulting models, are both contained. These models are integrated with the existing shuttle debris transport analysis software to provide an accurate and efficient engineering tool for analyzing debris sources and their potential for damage.

Bayesian Population Forecasting: Extending the Lee-Carter Method.

PubMed

Wiśniowski, Arkadiusz; Smith, Peter W F; Bijak, Jakub; Raymer, James; Forster, Jonathan J

2015-06-01

In this article, we develop a fully integrated and dynamic Bayesian approach to forecast populations by age and sex. The approach embeds the Lee-Carter type models for forecasting the age patterns, with associated measures of uncertainty, of fertility, mortality, immigration, and emigration within a cohort projection model. The methodology may be adapted to handle different data types and sources of information. To illustrate, we analyze time series data for the United Kingdom and forecast the components of population change to the year 2024. We also compare the results obtained from different forecast models for age-specific fertility, mortality, and migration. In doing so, we demonstrate the flexibility and advantages of adopting the Bayesian approach for population forecasting and highlight areas where this work could be extended.

Atmosphere-Wave-Ocean Coupling from Regional to Global Earth System Models for High-Impact Extreme Weather Prediction

NASA Astrophysics Data System (ADS)

Chen, S. S.; Curcic, M.

2017-12-01

The need for acurrate and integrated impact forecasts of extreme wind, rain, waves, and storm surge is growing as coastal population and built environment expand worldwide. A key limiting factor in forecasting impacts of extreme weather events associated with tropical cycle and winter storms is fully coupled atmosphere-wave-ocean model interface with explicit momentum and energy exchange. It is not only critical for accurate prediction of storm intensity, but also provides coherent wind, rian, ocean waves and currents forecasts for forcing for storm surge. The Unified Wave INterface (UWIN) has been developed for coupling of the atmosphere-wave-ocean models. UWIN couples the atmosphere, wave, and ocean models using the Earth System Modeling Framework (ESMF). It is a physically based and computationally efficient coupling sytem that is flexible to use in a multi-model system and portable for transition to the next generation global Earth system prediction mdoels. This standardized coupling framework allows researchers to develop and test air-sea coupling parameterizations and coupled data assimilation, and to better facilitate research-to-operation activities. It has been used and extensively tested and verified in regional coupled model forecasts of tropical cycles and winter storms (Chen and Curcic 2016, Curcic et al. 2016, and Judt et al. 2016). We will present 1) an overview of UWIN and its applications in fully coupled atmosphere-wave-ocean model predictions of hurricanes and coastal winter storms, and 2) implenmentation of UWIN in the NASA GMAO GEOS-5.

Integrated built-in-test false and missed alarms reduction based on forward infinite impulse response & recurrent finite impulse response dynamic neural networks

NASA Astrophysics Data System (ADS)

Cui, Yiqian; Shi, Junyou; Wang, Zili

2017-11-01

Built-in tests (BITs) are widely used in mechanical systems to perform state identification, whereas the BIT false and missed alarms cause trouble to the operators or beneficiaries to make correct judgments. Artificial neural networks (ANN) are previously used for false and missed alarms identification, which has the features such as self-organizing and self-study. However, these ANN models generally do not incorporate the temporal effect of the bottom-level threshold comparison outputs and the historical temporal features are not fully considered. To improve the situation, this paper proposes a new integrated BIT design methodology by incorporating a novel type of dynamic neural networks (DNN) model. The new DNN model is termed as Forward IIR & Recurrent FIR DNN (FIRF-DNN), where its component neurons, network structures, and input/output relationships are discussed. The condition monitoring false and missed alarms reduction implementation scheme based on FIRF-DNN model is also illustrated, which is composed of three stages including model training, false and missed alarms detection, and false and missed alarms suppression. Finally, the proposed methodology is demonstrated in the application study and the experimental results are analyzed.

Initial Coupling of the RELAP-7 and PRONGHORN Applications

DOE Office of Scientific and Technical Information (OSTI.GOV)

J. Ortensi; D. Andrs; A.A. Bingham

2012-10-01

Modern nuclear reactor safety codes require the ability to solve detailed coupled neutronic- thermal fluids problems. For larger cores, this implies fully coupled higher dimensionality spatial dynamics with appropriate feedback models that can provide enough resolution to accurately compute core heat generation and removal during steady and unsteady conditions. The reactor analysis code PRONGHORN is being coupled to RELAP-7 as a first step to extend RELAP’s current capabilities. This report details the mathematical models, the type of coupling, and the testing results from the integrated system. RELAP-7 is a MOOSE-based application that solves the continuity, momentum, and energy equations inmore » 1-D for a compressible fluid. The pipe and joint capabilities enable it to model parts of the power conversion unit. The PRONGHORN application, also developed on the MOOSE infrastructure, solves the coupled equations that define the neutron diffusion, fluid flow, and heat transfer in a full core model. The two systems are loosely coupled to simplify the transition towards a more complex infrastructure. The integration is tested on a simplified version of the OECD/NEA MHTGR-350 Coupled Neutronics-Thermal Fluids benchmark model.« less

From functional structure to packaging: full-printing fabrication of a microfluidic chip.

PubMed

Zheng, Fengyi; Pu, Zhihua; He, Enqi; Huang, Jiasheng; Yu, Bocheng; Li, Dachao; Li, Zhihong

2018-05-24

This paper presents a concept of a full-printing methodology aiming at convenient and fast fabrication of microfluidic devices. For the first time, we achieved a microfluidic biochemical sensor with all functional structures fabricated by inkjet printing, including electrodes, immobilized enzymes, microfluidic components and packaging. With the cost-effective and rapid process, this method provides the possibility of quick model validation of a novel lab-on-chip system. In this study, a three-electrode electrochemical system was integrated successfully with glucose oxidase immobilization gel and sealed in an ice channel, forming a disposable microfluidic sensor for glucose detection. This fully-printed chip was characterized and showed good sensitivity and a linear section at a low-level concentration of glucose (0-10 mM). With the aid of automatic equipment, the fully-printed sensor can be massively produced with low cost.

Personal resilience, cognitive appraisals, and coping: an integrative model of adjustment to abortion.

PubMed

Major, B; Richards, C; Cooper, M L; Cozzarelli, C; Zubek, J

1998-03-01

We hypothesized that the effects of personality (self-esteem, control, and optimism) on postabortion adaptation (distress, well-being, and decision satisfaction) would be fully mediated by preabortion cognitive appraisals (stress appraisals and self-efficacy appraisals) and postabortion coping. We further proposed that the effects of preabortion appraisals on adaptation would be fully mediated by postabortion coping. Results of a longitudinal study of 527 women who had first-trimester abortions supported our hypotheses. Women with more resilient personalities appraised their abortion as less stressful and had higher self-efficacy for coping with the abortion. More positive appraisals predicted greater acceptance/reframing coping and lesser avoidance/denial, venting, support seeking, and religious coping. Acceptance-reframing predicted better adjustment on all measures, whereas avoidance-denial and venting related to poorer adjustment on all measures. Greater support seeking was associated with reduced distress, and greater religious coping was associated with less decision satisfaction.

A 40 GHz fully integrated circuit with a vector network analyzer and a coplanar-line-based detection area for circulating tumor cell analysis using 65 nm CMOS technology

NASA Astrophysics Data System (ADS)

Nakanishi, Taiki; Matsunaga, Maya; Kobayashi, Atsuki; Nakazato, Kazuo; Niitsu, Kiichi

2018-03-01

A 40-GHz fully integrated CMOS-based circuit for circulating tumor cells (CTC) analysis, consisting of an on-chip vector network analyzer (VNA) and a highly sensitive coplanar-line-based detection area is presented in this paper. In this work, we introduce a fully integrated architecture that eliminates unwanted parasitic effects. The proposed analyzer was designed using 65 nm CMOS technology, and SPICE and MWS simulations were used to validate its operation. The simulation confirmed that the proposed circuit can measure S-parameter shifts resulting from the addition of various types of tumor cells to the detection area, the data of which are provided in a previous study: the |S 21| values for HepG2, A549, and HEC-1-A cells are -0.683, -0.580, and -0.623 dB, respectively. Additionally, the measurement demonstrated an S-parameters reduction of -25.7% when a silicone resin was put on the circuit. Hence, the proposed system is expected to contribute to cancer diagnosis.

An NFC-Enabled CMOS IC for a Wireless Fully Implantable Glucose Sensor.

PubMed

DeHennis, Andrew; Getzlaff, Stefan; Grice, David; Mailand, Marko

2016-01-01

This paper presents an integrated circuit (IC) that merges integrated optical and temperature transducers, optical interface circuitry, and a near-field communication (NFC)-enabled digital, wireless readout for a fully passive implantable sensor platform to measure glucose in people with diabetes. A flip-chip mounted LED and monolithically integrated photodiodes serve as the transduction front-end to enable fluorescence readout. A wide-range programmable transimpedance amplifier adapts the sensor signals to the input of an 11-bit analog-to-digital converter digitizing the measurements. Measurement readout is enabled by means of wireless backscatter modulation to a remote NFC reader. The system is able to resolve current levels of less than 10 pA with a single fluorescent measurement energy consumption of less than 1 μJ. The wireless IC is fabricated in a 0.6-μm-CMOS process and utilizes a 13.56-MHz-based ISO15693 for passive wireless readout through a NFC interface. The IC is utilized as the core interface to a fluorescent, glucose transducer to enable a fully implantable sensor-based continuous glucose monitoring system.

Recurrence formulas for fully exponentially correlated four-body wave functions

NASA Astrophysics Data System (ADS)

Harris, Frank E.

2009-03-01

Formulas are presented for the recursive generation of four-body integrals in which the integrand consists of arbitrary integer powers (≥-1) of all the interparticle distances rij , multiplied by an exponential containing an arbitrary linear combination of all the rij . These integrals are generalizations of those encountered using Hylleraas basis functions and include all that are needed to make energy computations on the Li atom and other four-body systems with a fully exponentially correlated Slater-type basis of arbitrary quantum numbers. The only quantities needed to start the recursion are the basic four-body integral first evaluated by Fromm and Hill plus some easily evaluated three-body “boundary” integrals. The computational labor in constructing integral sets for practical computations is less than when the integrals are generated using explicit formulas obtained by differentiating the basic integral with respect to its parameters. Computations are facilitated by using a symbolic algebra program (MAPLE) to compute array index pointers and present syntactically correct FORTRAN source code as output; in this way it is possible to obtain error-free high-speed evaluations with minimal effort. The work can be checked by verifying sum rules the integrals must satisfy.

ATLAS, an integrated structural analysis and design system. Volume 6: Design module theory

NASA Technical Reports Server (NTRS)

Backman, B. F.

1979-01-01

The automated design theory underlying the operation of the ATLAS Design Module is decribed. The methods, applications and limitations associated with the fully stressed design, the thermal fully stressed design and a regional optimization algorithm are presented. A discussion of the convergence characteristics of the fully stressed design is also included. Derivations and concepts specific to the ATLAS design theory are shown, while conventional terminology and established methods are identified by references.

The Sponsor Program: Facilitating Anticipatory Socialization for Personnel being Transferred in the United States Coast Guard.

DTIC Science & Technology

1980-12-01

acquisition." Following entry into the organization, a transitioner undergoes four areas of change to become fully integrated into the organization. First, the...that he/she has accepted the organization. Only when this psychological contract has been completed does the transitioner become a fully accepted...Questionnaire, respect- fully . Responses for each question are listed, followed by the number of times (frequency) each response was given and the percentage

DOE Office of Scientific and Technical Information (OSTI.GOV)

Collins, William D.; Craig, Anthony P.; Truesdale, John E.

The integrated Earth System Model (iESM) has been developed as a new tool for pro- jecting the joint human/climate system. The iESM is based upon coupling an Integrated Assessment Model (IAM) and an Earth System Model (ESM) into a common modeling in- frastructure. IAMs are the primary tool for describing the human–Earth system, including the sources of global greenhouse gases (GHGs) and short-lived species, land use and land cover change, and other resource-related drivers of anthropogenic climate change. ESMs are the primary scientific tools for examining the physical, chemical, and biogeochemical impacts of human-induced changes to the climate system. Themore » iESM project integrates the economic and human dimension modeling of an IAM and a fully coupled ESM within a sin- gle simulation system while maintaining the separability of each model if needed. Both IAM and ESM codes are developed and used by large communities and have been extensively applied in recent national and international climate assessments. By introducing heretofore- omitted feedbacks between natural and societal drivers, we can improve scientific under- standing of the human–Earth system dynamics. Potential applications include studies of the interactions and feedbacks leading to the timing, scale, and geographic distribution of emissions trajectories and other human influences, corresponding climate effects, and the subsequent impacts of a changing climate on human and natural systems. This paper de- scribes the formulation, requirements, implementation, testing, and resulting functionality of the first version of the iESM released to the global climate community.« less

DOE Office of Scientific and Technical Information (OSTI.GOV)

Collins, W. D.; Craig, A. P.; Truesdale, J. E.

The integrated Earth system model (iESM) has been developed as a new tool for projecting the joint human/climate system. The iESM is based upon coupling an integrated assessment model (IAM) and an Earth system model (ESM) into a common modeling infrastructure. IAMs are the primary tool for describing the human–Earth system, including the sources of global greenhouse gases (GHGs) and short-lived species (SLS), land use and land cover change (LULCC), and other resource-related drivers of anthropogenic climate change. ESMs are the primary scientific tools for examining the physical, chemical, and biogeochemical impacts of human-induced changes to the climate system. Themore » iESM project integrates the economic and human-dimension modeling of an IAM and a fully coupled ESM within a single simulation system while maintaining the separability of each model if needed. Both IAM and ESM codes are developed and used by large communities and have been extensively applied in recent national and international climate assessments. By introducing heretofore-omitted feedbacks between natural and societal drivers, we can improve scientific understanding of the human–Earth system dynamics. Potential applications include studies of the interactions and feedbacks leading to the timing, scale, and geographic distribution of emissions trajectories and other human influences, corresponding climate effects, and the subsequent impacts of a changing climate on human and natural systems. This paper describes the formulation, requirements, implementation, testing, and resulting functionality of the first version of the iESM released to the global climate community.« less

32 CFR 158.4 - Policy.

Code of Federal Regulations, 2013 CFR

2013-07-01

... program management processes during applicable contingency operations. (2) Comply with applicable U.S..., “Policy and Procedures for Determining Workforce Mix.” (4) Fully consider, plan for, integrate, and execute acquisition of, contracted support, including synchronizing and integrating contracted support...

32 CFR 158.4 - Policy.

Code of Federal Regulations, 2012 CFR

2012-07-01

... program management processes during applicable contingency operations. (2) Comply with applicable U.S..., “Policy and Procedures for Determining Workforce Mix.” (4) Fully consider, plan for, integrate, and execute acquisition of, contracted support, including synchronizing and integrating contracted support...

32 CFR 158.4 - Policy.

Code of Federal Regulations, 2014 CFR

2014-07-01

... program management processes during applicable contingency operations. (2) Comply with applicable U.S..., “Policy and Procedures for Determining Workforce Mix.” (4) Fully consider, plan for, integrate, and execute acquisition of, contracted support, including synchronizing and integrating contracted support...

Chemotherapy and treatment scheduling: the Johns Hopkins Oncology Center Outpatient Department.

PubMed Central

Majidi, F.; Enterline, J. P.; Ashley, B.; Fowler, M. E.; Ogorzalek, L. L.; Gaudette, R.; Stuart, G. J.; Fulton, M.; Ettinger, D. S.

1993-01-01

The Chemotherapy and Treatment Scheduling System provides integrated appointment and facility scheduling for very complex procedures. It is fully integrated with other scheduling systems at The Johns Hopkins Oncology Center and is supported by the Oncology Clinical Information System (OCIS). It provides a combined visual and textual environment for the scheduling of events that have multiple dimensions and dependencies on other scheduled events. It is also fully integrated with other clinical decision support and ancillary systems within OCIS. The system has resulted in better patient flow through the ambulatory care areas of the Center. Implementing the system required changes in behavior among physicians, staff, and patients. This system provides a working example of building a sophisticated rule-based scheduling system using a relatively simple paradigm. It also is an example of what can be achieved when there is total integration between the operational and clinical components of patient care automation. PMID:8130453

Enhancing vehicle cornering limit through sideslip and yaw rate control

NASA Astrophysics Data System (ADS)

Lu, Qian; Gentile, Pierangelo; Tota, Antonio; Sorniotti, Aldo; Gruber, Patrick; Costamagna, Fabio; De Smet, Jasper

2016-06-01

Fully electric vehicles with individually controlled drivetrains can provide a high degree of drivability and vehicle safety, all while increasing the cornering limit and the 'fun-to-drive' aspect. This paper investigates a new approach on how sideslip control can be integrated into a continuously active yaw rate controller to extend the limit of stable vehicle cornering and to allow sustained high values of sideslip angle. The controllability-related limitations of integrated yaw rate and sideslip control, together with its potential benefits, are discussed through the tools of multi-variable feedback control theory and non-linear phase-plane analysis. Two examples of integrated yaw rate and sideslip control systems are presented and their effectiveness is experimentally evaluated and demonstrated on a four-wheel-drive fully electric vehicle prototype. Results show that the integrated control system allows safe operation at the vehicle cornering limit at a specified sideslip angle independent of the tire-road friction conditions.

vECTlab—A fully integrated multi-modality Monte Carlo simulation framework for the radiological imaging sciences

NASA Astrophysics Data System (ADS)

Peter, Jörg; Semmler, Wolfhard

2007-10-01

Alongside and in part motivated by recent advances in molecular diagnostics, the development of dual-modality instruments for patient and dedicated small animal imaging has gained attention by diverse research groups. The desire for such systems is high not only to link molecular or functional information with the anatomical structures, but also for detecting multiple molecular events simultaneously at shorter total acquisition times. While PET and SPECT have been integrated successfully with X-ray CT, the advance of optical imaging approaches (OT) and the integration thereof into existing modalities carry a high application potential, particularly for imaging small animals. A multi-modality Monte Carlo (MC) simulation approach at present has been developed that is able to trace high-energy (keV) as well as optical (eV) photons concurrently within identical phantom representation models. We show that the involved two approaches for ray-tracing keV and eV photons can be integrated into a unique simulation framework which enables both photon classes to be propagated through various geometry models representing both phantoms and scanners. The main advantage of such integrated framework for our specific application is the investigation of novel tomographic multi-modality instrumentation intended for in vivo small animal imaging through time-resolved MC simulation upon identical phantom geometries. Design examples are provided for recently proposed SPECT-OT and PET-OT imaging systems.

Coordinating vendor-buyer decisions for imperfect quality items considering trade credit and fully backlogged shortages

NASA Astrophysics Data System (ADS)

Khanna, Aditi; Gautam, Prerna; Jaggi, Chandra K.

2016-03-01

Supply chain management has become a critical issue for modern business environments. In today's world of cooperative decision-making, individual decisions in order to reduce inventory costs may not lead to an overall optimal solution. Coordination is necessary among participants of supply chain to achieve better performance. There are legitimate and important efforts from the vendor to enhance the relation with buyer; one such effort is offering trade credit which has been a driver of growth and development of business between them. The cost of financing is a core consideration in effective financial management, in general and in context of business. Also, due to imperfect production a vendor may produce defective items which results in shortages. Motivated with these aspects, an integrated vendor-buyer inventory model is developed for imperfect quality items with allowable shortages; in which the vendor offers credit period to the buyer for payment. The objective is to minimize the total joint annual costs incurred by the vendor and the buyer by using integrated decision making approach. The expected total annual integrated cost is derived and a solution procedure is provided to find the optimal solution. Numerical analysis shows that the integrated model gives an impressive cost reduction, in comparison to independent decision policies by the vendor and the buyer.

Big data or bust: realizing the microbial genomics revolution.

PubMed

Raza, Sobia; Luheshi, Leila

2016-02-01

Pathogen genomics has the potential to transform the clinical and public health management of infectious diseases through improved diagnosis, detection and tracking of antimicrobial resistance and outbreak control. However, the wide-ranging benefits of this technology can only fully be realized through the timely collation, integration and sharing of genomic and clinical/epidemiological metadata by all those involved in the delivery of genomic-informed services. As part of our review on bringing pathogen genomics into 'health-service' practice, we undertook extensive stakeholder consultation to examine the factors integral to achieving effective data sharing and integration. Infrastructure tailored to the needs of clinical users, as well as practical support and policies to facilitate the timely and responsible sharing of data with relevant health authorities and beyond, are all essential. We propose a tiered data sharing and integration model to maximize the immediate and longer term utility of microbial genomics in healthcare. Realizing this model at the scale and sophistication necessary to support national and international infection management services is not uncomplicated. Yet the establishment of a clear data strategy is paramount if failures in containing disease spread due to inadequate knowledge sharing are to be averted, and substantial progress made in tackling the dangers posed by infectious diseases.

Standardized 3D Bioprinting of Soft Tissue Models with Human Primary Cells.

PubMed

Rimann, Markus; Bono, Epifania; Annaheim, Helene; Bleisch, Matthias; Graf-Hausner, Ursula

2016-08-01

Cells grown in 3D are more physiologically relevant than cells cultured in 2D. To use 3D models in substance testing and regenerative medicine, reproducibility and standardization are important. Bioprinting offers not only automated standardizable processes but also the production of complex tissue-like structures in an additive manner. We developed an all-in-one bioprinting solution to produce soft tissue models. The holistic approach included (1) a bioprinter in a sterile environment, (2) a light-induced bioink polymerization unit, (3) a user-friendly software, (4) the capability to print in standard labware for high-throughput screening, (5) cell-compatible inkjet-based printheads, (6) a cell-compatible ready-to-use BioInk, and (7) standard operating procedures. In a proof-of-concept study, skin as a reference soft tissue model was printed. To produce dermal equivalents, primary human dermal fibroblasts were printed in alternating layers with BioInk and cultured for up to 7 weeks. During long-term cultures, the models were remodeled and fully populated with viable and spreaded fibroblasts. Primary human dermal keratinocytes were seeded on top of dermal equivalents, and epidermis-like structures were formed as verified with hematoxylin and eosin staining and immunostaining. However, a fully stratified epidermis was not achieved. Nevertheless, this is one of the first reports of an integrative bioprinting strategy for industrial routine application. © 2015 Society for Laboratory Automation and Screening.

Sample extraction and injection with a microscale preconcentrator.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Robinson, Alex Lockwood; Chan, Helena Kai Lun

2007-09-01

This report details the development of a microfabricated preconcentrator that functions as a fully integrated chemical extractor-injector for a microscale gas chromatograph (GC). The device enables parts-per-billion detection and quantitative analysis of volatile organic compounds (VOCs) in indoor air with size and power advantages over macro-scale systems. The 44 mm{sup 3} preconcentrator extracts VOCs using highly adsorptive, granular forms of graphitized carbon black and carbon molecular sieves. The micron-sized silicon cavities have integrated heating and temperature sensing allowing low power, yet rapid heating to thermally desorb the collected VOCs (GC injection). The keys to device construction are a new adsorbent-solventmore » filling technique and solvent-tolerant wafer-level silicon-gold eutectic bonding technology. The product is the first granular adsorbent preconcentrator integrated at the wafer level. Other advantages include exhaustive VOC extraction and injection peak widths an order of magnitude narrower than predecessor prototypes. A mass transfer model, the first for any microscale preconcentrator, is developed to describe both adsorption and desorption behaviors. The physically intuitive model uses implicit and explicit finite differences to numerically solve the required partial differential equations. The model is applied to the adsorption and desorption of decane at various concentrations to extract Langmuir adsorption isotherm parameters from effluent curve measurements where properties are unknown a priori.« less

Integrated Scenario Modeling of NSTX Advanced Plasma Configurations

NASA Astrophysics Data System (ADS)

Kessel, Charles; Synakowski, Edward

2003-10-01

The Spherical Torus will provide an attractive fusion energy source if it can demonstrate the following major features: high elongation and triangularity, 100% non-inductive current with a credible path to high bootstrap fractions, non-solenoidal startup and current rampup, high beta with stabilization of RWM instabilities, and sufficiently high energy confinement. NSTX has specific experimental milestones to examine these features, and integrated scenario modeling is helping to understand how these configurations might be produced and what tools are needed to access this operating space. Simulations with the Tokamak Simulation Code (TSC), CURRAY, and JSOLVER/BALMSC/PEST2 have identified fully non-inductively sustained, high beta plasmas that rely on strong plasma shaping accomplished with a PF coil modification, off-axis current drive from Electron Bernstein Waves (EBW), flexible on-axis heating and CD from High Harmonic Fast Wave (HHFW) and Neutral Beam Injection (NBI), and density control. Ideal MHD stability shows that with wall stabilization through plasma rotation and/or RWM feedback coils, a beta of 40% is achievable, with 100% non-inductive current sustained for 4 current diffusion times. Experimental data and theory are combined to produce a best extrapolation to these regimes, which is continuously improved as the discharges approach these parameters, and theoretical/computational methods expand. Further investigations and development for integrated scenario modeling on NSTX is discussed.

ATLAS Cloud R&D

NASA Astrophysics Data System (ADS)

Panitkin, Sergey; Barreiro Megino, Fernando; Caballero Bejar, Jose; Benjamin, Doug; Di Girolamo, Alessandro; Gable, Ian; Hendrix, Val; Hover, John; Kucharczyk, Katarzyna; Medrano Llamas, Ramon; Love, Peter; Ohman, Henrik; Paterson, Michael; Sobie, Randall; Taylor, Ryan; Walker, Rodney; Zaytsev, Alexander; Atlas Collaboration

2014-06-01

The computing model of the ATLAS experiment was designed around the concept of grid computing and, since the start of data taking, this model has proven very successful. However, new cloud computing technologies bring attractive features to improve the operations and elasticity of scientific distributed computing. ATLAS sees grid and cloud computing as complementary technologies that will coexist at different levels of resource abstraction, and two years ago created an R&D working group to investigate the different integration scenarios. The ATLAS Cloud Computing R&D has been able to demonstrate the feasibility of offloading work from grid to cloud sites and, as of today, is able to integrate transparently various cloud resources into the PanDA workload management system. The ATLAS Cloud Computing R&D is operating various PanDA queues on private and public resources and has provided several hundred thousand CPU days to the experiment. As a result, the ATLAS Cloud Computing R&D group has gained a significant insight into the cloud computing landscape and has identified points that still need to be addressed in order to fully utilize this technology. This contribution will explain the cloud integration models that are being evaluated and will discuss ATLAS' learning during the collaboration with leading commercial and academic cloud providers.

An Update on Improvements to NiCE Support for RELAP-7

DOE Office of Scientific and Technical Information (OSTI.GOV)

McCaskey, Alex; Wojtowicz, Anna; Deyton, Jordan H.

The Multiphysics Object-Oriented Simulation Environment (MOOSE) is a framework that facilitates the development of applications that rely on finite-element analysis to solve a coupled, nonlinear system of partial differential equations. RELAP-7 represents an update to the venerable RELAP-5 simulator that is built upon this framework and attempts to model the balance-of-plant concerns in a full nuclear plant. This report details the continued support and integration of RELAP-7 and the NEAMS Integrated Computational Environment (NiCE). RELAP-7 is fully supported by the NiCE due to on-going work to tightly integrate NiCE with the MOOSE framework, and subsequently the applications built upon it.more » NiCE development throughout the first quarter of FY15 has focused on improvements, bug fixes, and feature additions to existing MOOSE-based application support. Specifically, this report will focus on improvements to the NiCE MOOSE Model Builder, the MOOSE application job launcher, and the 3D Nuclear Plant Viewer. This report also includes a comprehensive tutorial that guides RELAP-7 users through the basic NiCE workflow: from input generation and 3D Plant modeling, to massively parallel job launch and post-simulation data visualization.« less

Integrated Pest Management of the Southern Pine Beetle

Treesearch

Robert N. Coulson; Hannu Saarenmaa

2011-01-01

Integrated pest management (IPM) is the maintenance of destructive agents, including insects, at tolerable levels by the planned use of a variety of preventive, suppressive, or regulatory tactics and strategies that are ecologically and economically efficient and socially and politically acceptable. It is explicit that the actions taken are fully integrated into the...

Molecular Symmetry in Ab Initio Calculations

NASA Astrophysics Data System (ADS)

Madhavan, P. V.; Written, J. L.

1987-05-01

A scheme is presented for the construction of the Fock matrix in LCAO-SCF calculations and for the transformation of basis integrals to LCAO-MO integrals that can utilize several symmetry unique lists of integrals corresponding to different symmetry groups. The algorithm is fully compatible with vector processing machines and is especially suited for parallel processing machines.

The fully integrated biomedical engineering programme at Eindhoven University of Technology.

PubMed

Slaaf, D W; van Genderen, M H P

2009-05-01

The development of a fully integrated biomedical engineering programme (life sciences included from the start) is described. Details are provided about background, implementation, and didactic concept: design centred learning combined with courses. The curriculum has developed into a bachelor-master's programme with two different master's degrees: Master's Degree in Biomedical Engineering and Master's Degree in Medical Engineering. Recently, the programme has adopted semester programming, has included a major and minor in the bachelor's degree phase, and a true bachelor's degree final project. Details about the programme and data about where graduates find jobs are provided in this paper.

Leading-Color Fully Differential Two-Loop Soft Corrections to QCD Dipole Showers

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dulat, Falko; Höche, Stefan; Prestel, Stefan

We compute the next-to-leading order corrections to soft-gluon radiation differentially in the one-emission phase space. We show that their contribution to the evolution of color dipoles can be obtained in a modified subtraction scheme, such that both one- and two-emission terms are amenable to Monte-Carlo integration. The two-loop cusp anomalous dimension is recovered naturally upon integration over the full phase space. We present two independent implementations of the new algorithm in the two event generators Pythia and Sherpa, and we compare the resulting fully differential simulation to the CMW scheme.

Modelling water use in global hydrological models: review, challenges and directions

NASA Astrophysics Data System (ADS)

Bierkens, M. F.; de Graaf, I.; Wada, Y.; Wanders, N.; Van Beek, L. P.

2017-12-01

During the late 1980s and early 1990s, awareness of the shortage of global water resources lead to the first detailed global water resources assessments using regional statistics of water use and observations of meteorological and hydrological variables. Shortly thereafter, the first macroscale hydrological models (MHM) appeared. In these models, blue water (i.e., surface water and renewable groundwater) availability was calculated by accumulating runoff over a stream network and comparing it with population densities or with estimated water demand for agriculture, industry and households. In this talk we review the evolution of human impact modelling in global land models with a focus on global water resources, touching upon developments of the last 15 years: i.e. calculating human water scarcity; estimating groundwater depletion; adding dams and reservoirs; fully integrating water use (demand, withdrawal, consumption, return flow) in the hydrology; simulating the effects of land use change. We show example studies for each of these steps. We identify We identify major challenges that hamper the further development of integrated water resources modelling. Examples of these are: 1) simulating reservoir operations; 2) including local infrastructure and redistribution; 3) using the correct allocations rules; 4) projecting future water demand and water use. For each of these challenges we signify promising directions for further research.

Manufacturing and control of the aspherical mirrors for the telescope of the satellite Pleiades

NASA Astrophysics Data System (ADS)

Ducollet, Hélène; du Jeu, Christian; Fermé, Jean-Jacques

2017-11-01

For the Pleiades space program, SESO has been awarded the contract (fully completed), for the manufacturing of the whole set of telescope mirrors (4 mirrors, 2 flight models). These works did also include the mechanical design, manufacturing and mounting of the attachment flexures between the mirrors and the telescope main structure. This presentation is focused on the different steps of lightweighting, polishing, integration and control of these mirrors as well as a presentation of the existing SESO facilities and capabilities to produce such kind of aspherical components/sub-assemblies.

Development of an Integrated Modeling Framework for Simulations of Coastal Processes in Deltaic Environments Using High-Performance Computing

DTIC Science & Technology

2008-01-01

exceeds the local water depth. The approximation eliminates the vertical dimension of the elliptic equation that is normally required for the fully non...used for vertical resolution. The shallow water equations (SWE) are a set of non-linear hyperbolic equations. As the equations are derived under...linear standing wave with a wavelength of 10 m in a square 10 m by 10 m basin. The still water depth is 0.5 m. In order to compare with the analytical

Organomatics and organometrics: Novel platforms for long-term whole-organ culture

PubMed Central

Bruinsma, Bote G.; Yarmush, Martin L.; Uygun, Korkut

2014-01-01

Organ culture systems are instrumental as experimental whole-organ models of physiology and disease, as well as preservation modalities facilitating organ replacement therapies such as transplantation. Nevertheless, a coordinated system of machine perfusion components and integrated regulatory control has yet to be fully developed to achieve long-term maintenance of organ function ex vivo. Here we outline current strategies for organ culture, or organomatics, and how these systems can be regulated by means of computational algorithms, or organometrics, to achieve the organ culture platforms anticipated in modern-day biomedicine. PMID:25035864

Failure of continuum methods for determining the effective temperature of hot stars

NASA Technical Reports Server (NTRS)

Hummer, D. G.; Abbott, David C.; Voels, Stephen A.; Bohannan, Bruce

1988-01-01

It is demonstrated here that, for hot stars, methods based on the integrated continuum flux are completely unreliable discriminators of the effective temperature. Absorption line profiles provide much more accurate values of these parameters. It is not necessary to invoke nonradiative energy and momentum effects to explain the spectroscopic appearance of O-type stars of very different spectral type; rather, the observed spectra can be well modeled and fully interpreted by normal interaction of gas and radiation in stellar atmospheres of differing effective temperature and gravity.

Retooling CFD for hypersonic aircraft

NASA Technical Reports Server (NTRS)

Dwoyer, Douglas L.; Kutler, Paul; Povinelli, Louis A.

1987-01-01

The CFD facility requirements of hypersonic aircraft configuration design development are different from those thus far employed for reentry vehicle design, because (1) the airframe and the propulsion system must be fully integrated to achieve the desired performance; (2) the vehicle must be reusable, with minimum refurbishment requirements between flights; and (3) vehicle performance must be optimized for a wide range of Mach numbers. An evaluation is presently made of flow resolution within shock waves, transition and turbulence phenomenon tractability, chemical reaction modeling, and hypersonic boundary layer transition, with state-of-the-art CFD.

[Point of Care 2.0: Coagulation Monitoring Using Rotem® Sigma and Teg® 6S].

PubMed

Weber, Christian Friedrich; Zacharowski, Kai

2018-06-01

New-generation methods for point of care based coagulation monitoring enable fully automated viscoelastic analyses for the assessment of particular parts of hemostasis. Contrary to the measuring techniques of former models, the viscoelastic ROTEM ® sigma and TEG ® 6s analyses are performed in single-use test cartridges without time- and personnel-intensive pre-analytical procedures. This review highlights methodical strengths and limitations of the devices and meets concerns associated with their integration in routine clinical practice. Georg Thieme Verlag KG Stuttgart · New York.

Case based reasoning in criminal intelligence using forensic case data.

PubMed

Ribaux, O; Margot, P

2003-01-01

A model that is based on the knowledge of experienced investigators in the analysis of serial crime is suggested to bridge a gap between technology and methodology. Its purpose is to provide a solid methodology for the analysis of serial crimes that supports decision making in the deployment of resources, either by guiding proactive policing operations or helping the investigative process. Formalisation has helped to derive a computerised system that efficiently supports the reasoning processes in the analysis of serial crime. This novel approach fully integrates forensic science data.

VCM Process Design: An ABET 2000 Fully Compliant Project

ERIC Educational Resources Information Center

Benyahia, Farid

2005-01-01

A long experience in undergraduate vinyl chloride monomer (VCM) process design projects is shared in this paper. The VCM process design is shown to be fully compliant with ABET 2000 criteria by virtue of its abundance in chemical engineering principles, integration of interpersonal and interdisciplinary skills in design, safety, economics, and…

Autonomous Learning through Task-Based Instruction in Fully Online Language Courses

ERIC Educational Resources Information Center

Lee, Lina

2016-01-01

This study investigated the affordances for autonomous learning in a fully online learning environment involving the implementation of task-based instruction in conjunction with Web 2.0 technologies. To that end, four-skill-integrated tasks and digital tools were incorporated into the coursework. Data were collected using midterm reflections,…

An Instrumental Case Study of Administrative Smart Practices for Fully Online Programs and Degrees

ERIC Educational Resources Information Center

Gregory, Charles V.

2017-01-01

The purpose of this instrumental case study was to explore administrators' responses to significant administrative challenges of fully online programs and degrees. The case was a single public community college located in the Integrated Postsecondary Education Data System Plains Region. In this study Bardach's (1994) method to identify and…

Knowledge boosting: a graph-based integration approach with multi-omics data and genomic knowledge for cancer clinical outcome prediction

PubMed Central

Kim, Dokyoon; Joung, Je-Gun; Sohn, Kyung-Ah; Shin, Hyunjung; Park, Yu Rang; Ritchie, Marylyn D; Kim, Ju Han

2015-01-01

Objective Cancer can involve gene dysregulation via multiple mechanisms, so no single level of genomic data fully elucidates tumor behavior due to the presence of numerous genomic variations within or between levels in a biological system. We have previously proposed a graph-based integration approach that combines multi-omics data including copy number alteration, methylation, miRNA, and gene expression data for predicting clinical outcome in cancer. However, genomic features likely interact with other genomic features in complex signaling or regulatory networks, since cancer is caused by alterations in pathways or complete processes. Methods Here we propose a new graph-based framework for integrating multi-omics data and genomic knowledge to improve power in predicting clinical outcomes and elucidate interplay between different levels. To highlight the validity of our proposed framework, we used an ovarian cancer dataset from The Cancer Genome Atlas for predicting stage, grade, and survival outcomes. Results Integrating multi-omics data with genomic knowledge to construct pre-defined features resulted in higher performance in clinical outcome prediction and higher stability. For the grade outcome, the model with gene expression data produced an area under the receiver operating characteristic curve (AUC) of 0.7866. However, models of the integration with pathway, Gene Ontology, chromosomal gene set, and motif gene set consistently outperformed the model with genomic data only, attaining AUCs of 0.7873, 0.8433, 0.8254, and 0.8179, respectively. Conclusions Integrating multi-omics data and genomic knowledge to improve understanding of molecular pathogenesis and underlying biology in cancer should improve diagnostic and prognostic indicators and the effectiveness of therapies. PMID:25002459

Knowledge boosting: a graph-based integration approach with multi-omics data and genomic knowledge for cancer clinical outcome prediction.

PubMed

Kim, Dokyoon; Joung, Je-Gun; Sohn, Kyung-Ah; Shin, Hyunjung; Park, Yu Rang; Ritchie, Marylyn D; Kim, Ju Han

2015-01-01

Cancer can involve gene dysregulation via multiple mechanisms, so no single level of genomic data fully elucidates tumor behavior due to the presence of numerous genomic variations within or between levels in a biological system. We have previously proposed a graph-based integration approach that combines multi-omics data including copy number alteration, methylation, miRNA, and gene expression data for predicting clinical outcome in cancer. However, genomic features likely interact with other genomic features in complex signaling or regulatory networks, since cancer is caused by alterations in pathways or complete processes. Here we propose a new graph-based framework for integrating multi-omics data and genomic knowledge to improve power in predicting clinical outcomes and elucidate interplay between different levels. To highlight the validity of our proposed framework, we used an ovarian cancer dataset from The Cancer Genome Atlas for predicting stage, grade, and survival outcomes. Integrating multi-omics data with genomic knowledge to construct pre-defined features resulted in higher performance in clinical outcome prediction and higher stability. For the grade outcome, the model with gene expression data produced an area under the receiver operating characteristic curve (AUC) of 0.7866. However, models of the integration with pathway, Gene Ontology, chromosomal gene set, and motif gene set consistently outperformed the model with genomic data only, attaining AUCs of 0.7873, 0.8433, 0.8254, and 0.8179, respectively. Integrating multi-omics data and genomic knowledge to improve understanding of molecular pathogenesis and underlying biology in cancer should improve diagnostic and prognostic indicators and the effectiveness of therapies. © The Author 2014. Published by Oxford University Press on behalf of the American Medical Informatics Association.

SAS macro programs for geographically weighted generalized linear modeling with spatial point data: applications to health research.

PubMed

Chen, Vivian Yi-Ju; Yang, Tse-Chuan

2012-08-01

An increasing interest in exploring spatial non-stationarity has generated several specialized analytic software programs; however, few of these programs can be integrated natively into a well-developed statistical environment such as SAS. We not only developed a set of SAS macro programs to fill this gap, but also expanded the geographically weighted generalized linear modeling (GWGLM) by integrating the strengths of SAS into the GWGLM framework. Three features distinguish our work. First, the macro programs of this study provide more kernel weighting functions than the existing programs. Second, with our codes the users are able to better specify the bandwidth selection process compared to the capabilities of existing programs. Third, the development of the macro programs is fully embedded in the SAS environment, providing great potential for future exploration of complicated spatially varying coefficient models in other disciplines. We provided three empirical examples to illustrate the use of the SAS macro programs and demonstrated the advantages explained above. Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

Modeling Subgrid Scale Droplet Deposition in Multiphase-CFD

NASA Astrophysics Data System (ADS)

Agostinelli, Giulia; Baglietto, Emilio

2017-11-01

The development of first-principle-based constitutive equations for the Eulerian-Eulerian CFD modeling of annular flow is a major priority to extend the applicability of multiphase CFD (M-CFD) across all two-phase flow regimes. Two key mechanisms need to be incorporated in the M-CFD framework, the entrainment of droplets from the liquid film, and their deposition. Here we focus first on the aspect of deposition leveraging a separate effects approach. Current two-field methods in M-CFD do not include appropriate local closures to describe the deposition of droplets in annular flow conditions. As many integral correlations for deposition have been proposed for lumped parameters methods applications, few attempts exist in literature to extend their applicability to CFD simulations. The integral nature of the approach limits its applicability to fully developed flow conditions, without geometrical or flow variations, therefore negating the scope of CFD application. A new approach is proposed here that leverages local quantities to predict the subgrid-scale deposition rate. The methodology is first tested into a three-field approach CFD model.

Use of Annotations for Component and Framework Interoperability

NASA Astrophysics Data System (ADS)

David, O.; Lloyd, W.; Carlson, J.; Leavesley, G. H.; Geter, F.

2009-12-01

The popular programming languages Java and C# provide annotations, a form of meta-data construct. Software frameworks for web integration, web services, database access, and unit testing now take advantage of annotations to reduce the complexity of APIs and the quantity of integration code between the application and framework infrastructure. Adopting annotation features in frameworks has been observed to lead to cleaner and leaner application code. The USDA Object Modeling System (OMS) version 3.0 fully embraces the annotation approach and additionally defines a meta-data standard for components and models. In version 3.0 framework/model integration previously accomplished using API calls is now achieved using descriptive annotations. This enables the framework to provide additional functionality non-invasively such as implicit multithreading, and auto-documenting capabilities while achieving a significant reduction in the size of the model source code. Using a non-invasive methodology leads to models and modeling components with only minimal dependencies on the modeling framework. Since models and modeling components are not directly bound to framework by the use of specific APIs and/or data types they can more easily be reused both within the framework as well as outside of it. To study the effectiveness of an annotation based framework approach with other modeling frameworks, a framework-invasiveness study was conducted to evaluate the effects of framework design on model code quality. A monthly water balance model was implemented across several modeling frameworks and several software metrics were collected. The metrics selected were measures of non-invasive design methods for modeling frameworks from a software engineering perspective. It appears that the use of annotations positively impacts several software quality measures. In a next step, the PRMS model was implemented in OMS 3.0 and is currently being implemented for water supply forecasting in the western United States at the USDA NRCS National Water and Climate Center. PRMS is a component based modular precipitation-runoff model developed to evaluate the impacts of various combinations of precipitation, climate, and land use on streamflow and general basin hydrology. The new OMS 3.0 PRMS model source code is more concise and flexible as a result of using the new framework’s annotation based approach. The fully annotated components are now providing information directly for (i) model assembly and building, (ii) dataflow analysis for implicit multithreading, (iii) automated and comprehensive model documentation of component dependencies, physical data properties, (iv) automated model and component testing, and (v) automated audit-traceability to account for all model resources leading to a particular simulation result. Experience to date has demonstrated the multi-purpose value of using annotations. Annotations are also a feasible and practical method to enable interoperability among models and modeling frameworks. As a prototype example, model code annotations were used to generate binding and mediation code to allow the use of OMS 3.0 model components within the OpenMI context.

Cold Helium Pressurization for Liquid Oxygen / Liquid Methane Propulsion Systems: Fully-Integrated Initial Hot-Fire Test Results

NASA Technical Reports Server (NTRS)

Morehead, R. L.; Atwell, M. J.; Melcher, J. C.; Hurlbert, E. A.

2016-01-01

A prototype cold helium active pressurization system was incorporated into an existing liquid oxygen (LOX) / liquid methane (LCH4) prototype planetary lander and hot-fire tested to collect vehicle-level performance data. Results from this hot-fire test series were used to validate integrated models of the vehicle helium and propulsion systems and demonstrate system effectiveness for a throttling lander. Pressurization systems vary greatly in complexity and efficiency between vehicles, so a pressurization performance metric was also developed as a means to compare different active pressurization schemes. This implementation of an active repress system is an initial sizing draft. Refined implementations will be tested in the future, improving the general knowledge base for a cryogenic lander-based cold helium system.

Electrical and Mechanical Strategies to Enable Cardiac Repair and Regeneration

PubMed Central

Cao, Hung; Kang, Bong Jin; Lee, Chia-An; Shung, K. Kirk; Hsiai, Tzung K.

2015-01-01

Inadequate replacement of lost ventricular myocardium from myocardial infarction leads to heart failure. Investigating the regenerative capacity of mammalian hearts represents an emerging direction for tissue engineering and cell-based therapy. Recent advances in stem cells hold promise to restore cardiac functions. However, embryonic or induced pluripotent stem cell-derived cardiomyocytes lack functional phenotypes of the native myocardium, and transplanted tissues are not fully integrated for synchronized electrical and mechanical coupling with the host. In this context, this review highlights the mechanical and electrical strategies to promote cardiomyocyte maturation and integration, and to assess the functional phenotypes of regenerating myocardium. Simultaneous micro-electrocardiogram and high-frequency ultrasound techniques will also be introduced to assess electrical and mechanical coupling for small animal models of heart regeneration. PMID:25974948

Putting the Power of Configuration in the Hands of the Users

NASA Technical Reports Server (NTRS)

Al-Shihabi, Mary-Jo; Brown, Mark; Rigolini, Marianne

2011-01-01

Goal was to reduce the overall cost of human space flight while maintaining the most demanding standards for safety and mission success. In support of this goal, a project team was chartered to replace 18 legacy Space Shuttle nonconformance processes and systems with one fully integrated system Problem Reporting and Corrective Action (PRACA) processes provide a closed-loop system for the identification, disposition, resolution, closure, and reporting of all Space Shuttle hardware/software problems PRACA processes are integrated throughout the Space Shuttle organizational processes and are critical to assuring a safe and successful program Primary Project Objectives Develop a fully integrated system that provides an automated workflow with electronic signatures Support multiple NASA programs and contracts with a single "system" architecture Define standard processes, implement best practices, and minimize process variations

Elucidating Critical Zone Process Interactions with an Integrated Hydrology Model in a Headwaters Research Catchment

NASA Astrophysics Data System (ADS)

Collins, C.; Maxwell, R. M.

2017-12-01

Providence Creek (P300) watershed is an alpine headwaters catchment located at the Southern Sierra Critical Zone Observatory (SSCZO). Evidence of groundwater-dependent vegetation and drought-induced tree mortality at P300 along with the effect of subsurface characterization on mountain ecohydrology motivates this study. A hyper resolution integrated hydrology model of this site, along with extensive instrumentation, provides an opportunity to study the effects of lateral groundwater flow on vegetation's tolerance to drought. ParFlow-CLM is a fully integrated surface-subsurface model that is driven with reconstructed meteorology, such as the North American Land Data Assimilation System project phase 2 (NLDAS-2) dataset. However, large-scale data products mute orographic effects on climate at smaller scales. Climate variables often do not behave uniformly in highly heterogeneous mountain regions. Therefore, forcing physically-based integrated hydrologic models—especially of mountain headwaters catchments—with a large-scale data product is a major challenge. Obtaining reliable observations in complex terrain is challenging and while climate data products introduce uncertainties likewise, documented discrepancies between several data products and P300 observations suggest these data products may suffice. To tackle these issues, a suite of simulations was run to parse out (1) the effects of climate data source (data products versus observations) and (2) the effects of climate data spatial variability. One tool for evaluating the effect of climate data on model outputs is the relationship between latent head flux (LH) and evapotranspiration (ET) partitioning with water table depth (WTD). This zone of LH sensitivity to WTD is referred to as the "critical zone." Preliminary results suggest that these critical zone relationships are preserved despite forcing albeit significant shifts in magnitude. These results demonstrate that integrated hydrology models are sensitive to climate data thereby impacting the accuracy of hydrologic modeling of headwaters catchments used for water management and planning purposes and exploring the effects of climate change perturbations.

Conversion of Component-Based Point Definition to VSP Model and Higher Order Meshing

NASA Technical Reports Server (NTRS)

Ordaz, Irian

2011-01-01

Vehicle Sketch Pad (VSP) has become a powerful conceptual and parametric geometry tool with numerous export capabilities for third-party analysis codes as well as robust surface meshing capabilities for computational fluid dynamics (CFD) analysis. However, a capability gap currently exists for reconstructing a fully parametric VSP model of a geometry generated by third-party software. A computer code called GEO2VSP has been developed to close this gap and to allow the integration of VSP into a closed-loop geometry design process with other third-party design tools. Furthermore, the automated CFD surface meshing capability of VSP are demonstrated for component-based point definition geometries in a conceptual analysis and design framework.

A healthcare Lean Six Sigma System for postanesthesia care unit workflow improvement.

PubMed

Kuo, Alex Mu-Hsing; Borycki, Elizabeth; Kushniruk, Andre; Lee, Te-Shu

2011-01-01

The aim of this article is to propose a new model called Healthcare Lean Six Sigma System that integrates Lean and Six Sigma methodologies to improve workflow in a postanesthesia care unit. The methodology of the proposed model is fully described. A postanesthesia care unit case study is also used to demonstrate the benefits of using the Healthcare Lean Six Sigma System model by combining Lean and Six Sigma methodologies together. The new model bridges the service gaps between health care providers and patients, balances the requirements of health care managers, and delivers health care services to patients by taking the benefits of the Lean speed and Six Sigma high-quality principles. The full benefits of the new model will be realized when applied at both strategic and operational levels. For further research, we will examine how the proposed model is used in different real-world case studies.

Automated Analysis of Stateflow Models

NASA Technical Reports Server (NTRS)

Bourbouh, Hamza; Garoche, Pierre-Loic; Garion, Christophe; Gurfinkel, Arie; Kahsaia, Temesghen; Thirioux, Xavier

2017-01-01

Stateflow is a widely used modeling framework for embedded and cyber physical systems where control software interacts with physical processes. In this work, we present a framework a fully automated safety verification technique for Stateflow models. Our approach is two-folded: (i) we faithfully compile Stateflow models into hierarchical state machines, and (ii) we use automated logic-based verification engine to decide the validity of safety properties. The starting point of our approach is a denotational semantics of State flow. We propose a compilation process using continuation-passing style (CPS) denotational semantics. Our compilation technique preserves the structural and modal behavior of the system. The overall approach is implemented as an open source toolbox that can be integrated into the existing Mathworks Simulink Stateflow modeling framework. We present preliminary experimental evaluations that illustrate the effectiveness of our approach in code generation and safety verification of industrial scale Stateflow models.

Integration of animal health, food pathogen and foodborne disease surveillance in the Americas.

PubMed

Hulebak, K; Rodricks, J; Smith DeWaal, C

2013-08-01

This paper describes the characteristics of surveillance and the attempts made in the Americas to institute truly integrated surveillance systems that bring together disease surveillance of medically treated clinical populations with disease surveillance for food-production animals. Characteristics of an ideal, integrated food safety system are described. Systematic surveillance programmes in the Americas vary widely in scope and reliability, and none is fully integrated. Estimates of foodborne disease rates, particularly in North America, are becoming increasingly accurate, and programmes such as those promoted by the Pan American Health Organization are gradually leading to improvements in estimates of the foodborne disease burden in Latin America. Linking foodborne diseases to their sources is necessary for reducing disease incidence, and the World Health Organization's Global Foodborne Infections Network is building global capacity in this area. Activities in these areas in the Americas are described in detail. There is now clear recognition that there are dynamic links between infectious diseases occurring in wildlife and livestock and those occurring in humans, and this has led to calls from organisations such as the US National Academy of Sciences and the American Veterinary Medical Association to integrate surveillance programmes for zoonotic and human diseases. Models for the development of such integrated programmes, at local, national and international levels, are described. To be effective, such models must incorporate programmes to capture information from numerous, discrete surveillance systems in a way that allows rapid analysis to identify zoonotic and human disease connections. No effective integration now exists, but there are signals that governments in the Americas are working together towards this goal.

A 3.2-GHz fully integrated low-phase noise CMOS VCO with self-biasing current source for the IEEE 802.11a/hiperLAN WLAN standard

NASA Astrophysics Data System (ADS)

Quemada, C.; Adin, I.; Bistue, G.; Berenguer, R.; Mendizabal, J.

2005-06-01

A 3.3V, fully integrated 3.2-GHz voltage-controlled oscillator (VCO) is designed in a 0.18μm CMOS technology for the IEE 802.11a/HiperLAN WLAN standard for the UNII band from 5.15 to 5.35 GHz. The VCO is tunable between 2.85 GHz and 3.31 GHz. NMOS architecture with self-biasing current of the tank source is chosen. A startup circuit has been employed to avoid zero initial current. Current variation is lower than 1% for voltage supply variations of 10%. The use of a self-biasing current source in the tank provides a greater safety in the transconductance value and allows running along more extreme point operation The designed VCO displays a phase noise and output power of -98dBc/Hz (at 100 KHz offset frequency) and 0dBm respectively. This phase noise has been obtained with inductors of 2.2nH and quality factor of 12 at 3.2 GHz, and P-N junction varactors whose quality factor is estimated to exceed 40 at 3.2 GHz. These passive components have been fabricated, measured and modeled previously. The core of the VCO consumes 33mW DC power.

A cell-based computational model of early embryogenesis coupling mechanical behaviour and gene regulation

NASA Astrophysics Data System (ADS)

Delile, Julien; Herrmann, Matthieu; Peyriéras, Nadine; Doursat, René

2017-01-01

The study of multicellular development is grounded in two complementary domains: cell biomechanics, which examines how physical forces shape the embryo, and genetic regulation and molecular signalling, which concern how cells determine their states and behaviours. Integrating both sides into a unified framework is crucial to fully understand the self-organized dynamics of morphogenesis. Here we introduce MecaGen, an integrative modelling platform enabling the hypothesis-driven simulation of these dual processes via the coupling between mechanical and chemical variables. Our approach relies upon a minimal `cell behaviour ontology' comprising mesenchymal and epithelial cells and their associated behaviours. MecaGen enables the specification and control of complex collective movements in 3D space through a biologically relevant gene regulatory network and parameter space exploration. Three case studies investigating pattern formation, epithelial differentiation and tissue tectonics in zebrafish early embryogenesis, the latter with quantitative comparison to live imaging data, demonstrate the validity and usefulness of our framework.

Semiotic diversity in utterance production and the concept of 'language'.

PubMed

Kendon, Adam

2014-09-19

Sign language descriptions that use an analytic model borrowed from spoken language structural linguistics have proved to be not fully appropriate. Pictorial and action-like modes of expression are integral to how signed utterances are constructed and to how they work. However, observation shows that speakers likewise use kinesic and vocal expressions that are not accommodated by spoken language structural linguistic models, including pictorial and action-like modes of expression. These, also, are integral to how speaker utterances in face-to-face interaction are constructed and to how they work. Accordingly, the object of linguistic inquiry should be revised, so that it comprises not only an account of the formal abstract systems that utterances make use of, but also an account of how the semiotically diverse resources that all languaging individuals use are organized in relation to one another. Both language as an abstract system and languaging should be the concern of linguistics. © 2014 The Author(s) Published by the Royal Society. All rights reserved.

Approach to Modeling Boundary Layer Ingestion Using a Fully Coupled Propulsion-RANS Model

NASA Technical Reports Server (NTRS)

Gray, Justin; Mader, Charles A.; Kenway, Gaetan K. W.; Martins, Joaquim R. R. A.

2017-01-01

Although boundary layer ingestion (BLI), or wake ingestion, is commonly applied in marine propulsion applications, it has not yet seen wide-spread adoption in aircraft applications. However, recent studies have predicted that BLI offers a potential for a 10 reduction in aircraft fuel burn, even on a fairly traditional aircraft configuration. This dramatic reduction in fuel burn is achieved via tight integration of the propulsion system and airframe aerodynamics, but actually realizing such large performance gains will require modifying the aircraft design process to account for this integration. Traditionally, in aircraft design, the airframe and the propulsion system are designed separately and then the engine sizing is managed with a rubber-engine approach. This works when the propulsion system is placed in the free-stream air, away from the aerodynamic influence of the airframe, and it is reasonable to assume that small changes to either system won't have a strong impact on the other.

Density-functional theory simulation of large quantum dots

NASA Astrophysics Data System (ADS)

Jiang, Hong; Baranger, Harold U.; Yang, Weitao

2003-10-01

Kohn-Sham spin-density functional theory provides an efficient and accurate model to study electron-electron interaction effects in quantum dots, but its application to large systems is a challenge. Here an efficient method for the simulation of quantum dots using density-function theory is developed; it includes the particle-in-the-box representation of the Kohn-Sham orbitals, an efficient conjugate-gradient method to directly minimize the total energy, a Fourier convolution approach for the calculation of the Hartree potential, and a simplified multigrid technique to accelerate the convergence. We test the methodology in a two-dimensional model system and show that numerical studies of large quantum dots with several hundred electrons become computationally affordable. In the noninteracting limit, the classical dynamics of the system we study can be continuously varied from integrable to fully chaotic. The qualitative difference in the noninteracting classical dynamics has an effect on the quantum properties of the interacting system: integrable classical dynamics leads to higher-spin states and a broader distribution of spacing between Coulomb blockade peaks.

Distributed Cooperation Solution Method of Complex System Based on MAS

NASA Astrophysics Data System (ADS)

Weijin, Jiang; Yuhui, Xu

To adapt the model in reconfiguring fault diagnosing to dynamic environment and the needs of solving the tasks of complex system fully, the paper introduced multi-Agent and related technology to the complicated fault diagnosis, an integrated intelligent control system is studied in this paper. Based on the thought of the structure of diagnostic decision and hierarchy in modeling, based on multi-layer decomposition strategy of diagnosis task, a multi-agent synchronous diagnosis federation integrated different knowledge expression modes and inference mechanisms are presented, the functions of management agent, diagnosis agent and decision agent are analyzed, the organization and evolution of agents in the system are proposed, and the corresponding conflict resolution algorithm in given, Layered structure of abstract agent with public attributes is build. System architecture is realized based on MAS distributed layered blackboard. The real world application shows that the proposed control structure successfully solves the fault diagnose problem of the complex plant, and the special advantage in the distributed domain.

Integrating Decision Tree and Hidden Markov Model (HMM) for Subtype Prediction of Human Influenza A Virus

NASA Astrophysics Data System (ADS)

Attaluri, Pavan K.; Chen, Zhengxin; Weerakoon, Aruna M.; Lu, Guoqing

Multiple criteria decision making (MCDM) has significant impact in bioinformatics. In the research reported here, we explore the integration of decision tree (DT) and Hidden Markov Model (HMM) for subtype prediction of human influenza A virus. Infection with influenza viruses continues to be an important public health problem. Viral strains of subtype H3N2 and H1N1 circulates in humans at least twice annually. The subtype detection depends mainly on the antigenic assay, which is time-consuming and not fully accurate. We have developed a Web system for accurate subtype detection of human influenza virus sequences. The preliminary experiment showed that this system is easy-to-use and powerful in identifying human influenza subtypes. Our next step is to examine the informative positions at the protein level and extend its current functionality to detect more subtypes. The web functions can be accessed at http://glee.ist.unomaha.edu/.

Declic: design, integration and testing of a multi configurable instrument using optical diagnostics to study directional solidification and critical fluids

NASA Astrophysics Data System (ADS)

Durieux, A.; Martin, B.; Laubier, D.

2017-11-01

DECLIC, a Facility dedicated to the study of transparent media under microgravity, will be used in an ISS EXPRESS Rack. This paper focuses on the EXL which contains two optical boxes disposed on two opposite sides of the cavity where the Inserts to be studied shall be locked. At the moment, three types of inserts are planned to be accommodated in the EXL. Various optical diagnostics are available by configuring the EXL (sources, sensors, mechanisms). After the presentation of the EXL design, this article deals with some manufacturing and testing aspects, such as the use of COTS (cameras). Specific OGSE have been developed in order to simulate the optical interfaces and the propagation of beams in the inserts. Three models of the EXL have been integrated and fully tested, including the Flight Model. The sequence of tests, the performances measured, and then some images of the experiments performed with the inserts will be presented.

MathWorks Simulink and C++ integration with the new VLT PLC-based standard development platform for instrument control systems

NASA Astrophysics Data System (ADS)

Kiekebusch, Mario J.; Di Lieto, Nicola; Sandrock, Stefan; Popovic, Dan; Chiozzi, Gianluca

2014-07-01

ESO is in the process of implementing a new development platform, based on PLCs, for upcoming VLT control systems (new instruments and refurbishing of existing systems to manage obsolescence issues). In this context, we have evaluated the integration and reuse of existing C++ libraries and Simulink models into the real-time environment of BECKHOFF Embedded PCs using the capabilities of the latest version of TwinCAT software and MathWorks Embedded Coder. While doing so the aim was to minimize the impact of the new platform by adopting fully tested solutions implemented in C++. This allows us to reuse the in house expertise, as well as extending the normal capabilities of the traditional PLC programming environments. We present the progress of this work and its application in two concrete cases: 1) field rotation compensation for instrument tracking devices like derotators, 2) the ESO standard axis controller (ESTAC), a generic model-based controller implemented in Simulink and used for the control of telescope main axes.

Fully CMOS-compatible titanium nitride nanoantennas

DOE Office of Scientific and Technical Information (OSTI.GOV)

Briggs, Justin A., E-mail: jabriggs@stanford.edu; Department of Materials Science and Engineering, Stanford University, 496 Lomita Mall, Stanford, California 94305; Naik, Gururaj V.

CMOS-compatible fabrication of plasmonic materials and devices will accelerate the development of integrated nanophotonics for information processing applications. Using low-temperature plasma-enhanced atomic layer deposition (PEALD), we develop a recipe for fully CMOS-compatible titanium nitride (TiN) that is plasmonic in the visible and near infrared. Films are grown on silicon, silicon dioxide, and epitaxially on magnesium oxide substrates. By optimizing the plasma exposure per growth cycle during PEALD, carbon and oxygen contamination are reduced, lowering undesirable loss. We use electron beam lithography to pattern TiN nanopillars with varying diameters on silicon in large-area arrays. In the first reported single-particle measurements onmore » plasmonic TiN, we demonstrate size-tunable darkfield scattering spectroscopy in the visible and near infrared regimes. The optical properties of this CMOS-compatible material, combined with its high melting temperature and mechanical durability, comprise a step towards fully CMOS-integrated nanophotonic information processing.« less

FULLY COUPLED "ONLINE" CHEMISTRY WITHIN THE WRF MODEL

EPA Science Inventory

A fully coupled "online" Weather Research and Forecasting/Chemistry (WRF/Chem) model has been developed. The air quality component of the model is fully consistent with the meteorological component; both components use the same transport scheme (mass and scalar preserving), the s...

Integrated earth system dynamic modeling for life cycle impact assessment of ecosystem services.

PubMed

Arbault, Damien; Rivière, Mylène; Rugani, Benedetto; Benetto, Enrico; Tiruta-Barna, Ligia

2014-02-15

Despite the increasing awareness of our dependence on Ecosystem Services (ES), Life Cycle Impact Assessment (LCIA) does not explicitly and fully assess the damages caused by human activities on ES generation. Recent improvements in LCIA focus on specific cause-effect chains, mainly related to land use changes, leading to Characterization Factors (CFs) at the midpoint assessment level. However, despite the complexity and temporal dynamics of ES, current LCIA approaches consider the environmental mechanisms underneath ES to be independent from each other and devoid of dynamic character, leading to constant CFs whose representativeness is debatable. This paper takes a step forward and is aimed at demonstrating the feasibility of using an integrated earth system dynamic modeling perspective to retrieve time- and scenario-dependent CFs that consider the complex interlinkages between natural processes delivering ES. The GUMBO (Global Unified Metamodel of the Biosphere) model is used to quantify changes in ES production in physical terms - leading to midpoint CFs - and changes in human welfare indicators, which are considered here as endpoint CFs. The interpretation of the obtained results highlights the key methodological challenges to be solved to consider this approach as a robust alternative to the mainstream rationale currently adopted in LCIA. Further research should focus on increasing the granularity of environmental interventions in the modeling tools to match current standards in LCA and on adapting the conceptual approach to a spatially-explicit integrated model. Copyright © 2013 Elsevier B.V. All rights reserved.

Cooley building opens in Houston. Demonstrates value of fully integrated marketing communications.

PubMed

Rees, Tom

2002-01-01

The Texas Heart Institute at St. Luke's Episcopal HospiTal in Houston dedicated its new 10-story Denton A. Cooley Building in January. The structure opened with a fanfare, thanks to a well-integrated marketing communications program.

Toward an Integrative Computational Model of the Guinea Pig Cardiac Myocyte

PubMed Central

Gauthier, Laura Doyle; Greenstein, Joseph L.; Winslow, Raimond L.

2012-01-01

The local control theory of excitation-contraction (EC) coupling asserts that regulation of calcium (Ca2+) release occurs at the nanodomain level, where openings of single L-type Ca2+ channels (LCCs) trigger openings of small clusters of ryanodine receptors (RyRs) co-localized within the dyad. A consequence of local control is that the whole-cell Ca2+ transient is a smooth continuous function of influx of Ca2+ through LCCs. While this so-called graded release property has been known for some time, its functional importance to the integrated behavior of the cardiac ventricular myocyte has not been fully appreciated. We previously formulated a biophysically based model, in which LCCs and RyRs interact via a coarse-grained representation of the dyadic space. The model captures key features of local control using a low-dimensional system of ordinary differential equations. Voltage-dependent gain and graded Ca2+ release are emergent properties of this model by virtue of the fact that model formulation is closely based on the sub-cellular basis of local control. In this current work, we have incorporated this graded release model into a prior model of guinea pig ventricular myocyte electrophysiology, metabolism, and isometric force production. The resulting integrative model predicts the experimentally observed causal relationship between action potential (AP) shape and timing of Ca2+ and force transients, a relationship that is not explained by models lacking the graded release property. Model results suggest that even relatively subtle changes in AP morphology that may result, for example, from remodeling of membrane transporter expression in disease or spatial variation in cell properties, may have major impact on the temporal waveform of Ca2+ transients, thus influencing tissue level electromechanical function. PMID:22783206

Toward an integrative computational model of the Guinea pig cardiac myocyte.

PubMed

Gauthier, Laura Doyle; Greenstein, Joseph L; Winslow, Raimond L

2012-01-01

The local control theory of excitation-contraction (EC) coupling asserts that regulation of calcium (Ca(2+)) release occurs at the nanodomain level, where openings of single L-type Ca(2+) channels (LCCs) trigger openings of small clusters of ryanodine receptors (RyRs) co-localized within the dyad. A consequence of local control is that the whole-cell Ca(2+) transient is a smooth continuous function of influx of Ca(2+) through LCCs. While this so-called graded release property has been known for some time, its functional importance to the integrated behavior of the cardiac ventricular myocyte has not been fully appreciated. We previously formulated a biophysically based model, in which LCCs and RyRs interact via a coarse-grained representation of the dyadic space. The model captures key features of local control using a low-dimensional system of ordinary differential equations. Voltage-dependent gain and graded Ca(2+) release are emergent properties of this model by virtue of the fact that model formulation is closely based on the sub-cellular basis of local control. In this current work, we have incorporated this graded release model into a prior model of guinea pig ventricular myocyte electrophysiology, metabolism, and isometric force production. The resulting integrative model predicts the experimentally observed causal relationship between action potential (AP) shape and timing of Ca(2+) and force transients, a relationship that is not explained by models lacking the graded release property. Model results suggest that even relatively subtle changes in AP morphology that may result, for example, from remodeling of membrane transporter expression in disease or spatial variation in cell properties, may have major impact on the temporal waveform of Ca(2+) transients, thus influencing tissue level electromechanical function.

Design, analysis, and testing of the Phase 1 CSI Evolutionary Model erectable truss

NASA Technical Reports Server (NTRS)

Gronet, M. J.; Davis, D. A.; Kintis, D. H.; Brillhart, R. D.; Atkins, E. M.

1992-01-01

This report addressed the design, analysis, and testing of the erectable truss structure for the Phase 1 CSI Evolutionary Model (CEM) testbed. The Phase 1 CEM testbed is the second testbed to form part of an ongoing program of focused research at NASA/LaRC in the development of Controls-Structures Integration (CSI) technology. The Phase 1 CEM contains the same overall geometry, weight, and sensor locations as the Phase 0 CEM, but is based in an integrated controller and structure design, whereby both structure and controller design variables are sized simultaneously. The Phase 1 CEM design features seven truss sections composed of struts with tailored mass and stiffness properties. A common erectable joint is used and the strut stiffness is tailored by varying the cross-sectional area. To characterize the structure, static tests were conducted on individual struts and 10-bay truss assemblies. Dynamic tests were conducted on 10-bay truss assemblies as well as the fully-assembled CEM truss. The results indicate that the static and dynamic properties of the structure are predictable, well-characterized, and within the performance requirements established during the Phase 1 CEM integrated controller/structure design analysis.

An architecture and model for cognitive engineering simulation analysis - Application to advanced aviation automation

NASA Technical Reports Server (NTRS)

Corker, Kevin M.; Smith, Barry R.

1993-01-01

The process of designing crew stations for large-scale, complex automated systems is made difficult because of the flexibility of roles that the crew can assume, and by the rapid rate at which system designs become fixed. Modern cockpit automation frequently involves multiple layers of control and display technology in which human operators must exercise equipment in augmented, supervisory, and fully automated control modes. In this context, we maintain that effective human-centered design is dependent on adequate models of human/system performance in which representations of the equipment, the human operator(s), and the mission tasks are available to designers for manipulation and modification. The joint Army-NASA Aircrew/Aircraft Integration (A3I) Program, with its attendant Man-machine Integration Design and Analysis System (MIDAS), was initiated to meet this challenge. MIDAS provides designers with a test bed for analyzing human-system integration in an environment in which both cognitive human function and 'intelligent' machine function are described in similar terms. This distributed object-oriented simulation system, its architecture and assumptions, and our experiences from its application in advanced aviation crew stations are described.

Systems Genetics as a Tool to Identify Master Genetic Regulators in Complex Disease.

PubMed

Moreno-Moral, Aida; Pesce, Francesco; Behmoaras, Jacques; Petretto, Enrico

2017-01-01

Systems genetics stems from systems biology and similarly employs integrative modeling approaches to describe the perturbations and phenotypic effects observed in a complex system. However, in the case of systems genetics the main source of perturbation is naturally occurring genetic variation, which can be analyzed at the systems-level to explain the observed variation in phenotypic traits. In contrast with conventional single-variant association approaches, the success of systems genetics has been in the identification of gene networks and molecular pathways that underlie complex disease. In addition, systems genetics has proven useful in the discovery of master trans-acting genetic regulators of functional networks and pathways, which in many cases revealed unexpected gene targets for disease. Here we detail the central components of a fully integrated systems genetics approach to complex disease, starting from assessment of genetic and gene expression variation, linking DNA sequence variation to mRNA (expression QTL mapping), gene regulatory network analysis and mapping the genetic control of regulatory networks. By summarizing a few illustrative (and successful) examples, we highlight how different data-modeling strategies can be effectively integrated in a systems genetics study.

Integrating evo-devo with ecology for a better understanding of phenotypic evolution

PubMed Central

Emília Santos, M.; Berger, Chloé S.; Refki, Peter N.

2015-01-01

Evolutionary developmental biology (evo-devo) has provided invaluable contributions to our understanding of the mechanistic relationship between genotypic and phenotypic change. Similarly, evolutionary ecology has greatly advanced our understanding of the relationship between the phenotype and the environment. To fully understand the evolution of organismal diversity, a thorough integration of these two fields is required. This integration remains highly challenging because model systems offering a rich ecological and evolutionary background, together with the availability of developmental genetic tools and genomic resources, are scarce. In this review, we introduce the semi-aquatic bugs (Gerromorpha, Heteroptera) as original models well suited to study why and how organisms diversify. The Gerromorpha invaded water surfaces over 200 mya and diversified into a range of remarkable new forms within this new ecological habitat. We summarize the biology and evolutionary history of this group of insects and highlight a set of characters associated with the habitat change and the diversification that followed. We further discuss the morphological, behavioral, molecular and genomic tools available that together make semi-aquatic bugs a prime model for integration across disciplines. We present case studies showing how the implementation and combination of these approaches can advance our understanding of how the interaction between genotypes, phenotypes and the environment drives the evolution of distinct morphologies. Finally, we explain how the same set of experimental designs can be applied in other systems to address similar biological questions. PMID:25750411

Integrating evo-devo with ecology for a better understanding of phenotypic evolution.

PubMed

Santos, M Emília; Berger, Chloé S; Refki, Peter N; Khila, Abderrahman

2015-11-01

Evolutionary developmental biology (evo-devo) has provided invaluable contributions to our understanding of the mechanistic relationship between genotypic and phenotypic change. Similarly, evolutionary ecology has greatly advanced our understanding of the relationship between the phenotype and the environment. To fully understand the evolution of organismal diversity, a thorough integration of these two fields is required. This integration remains highly challenging because model systems offering a rich ecological and evolutionary background, together with the availability of developmental genetic tools and genomic resources, are scarce. In this review, we introduce the semi-aquatic bugs (Gerromorpha, Heteroptera) as original models well suited to study why and how organisms diversify. The Gerromorpha invaded water surfaces over 200 mya and diversified into a range of remarkable new forms within this new ecological habitat. We summarize the biology and evolutionary history of this group of insects and highlight a set of characters associated with the habitat change and the diversification that followed. We further discuss the morphological, behavioral, molecular and genomic tools available that together make semi-aquatic bugs a prime model for integration across disciplines. We present case studies showing how the implementation and combination of these approaches can advance our understanding of how the interaction between genotypes, phenotypes and the environment drives the evolution of distinct morphologies. Finally, we explain how the same set of experimental designs can be applied in other systems to address similar biological questions. © The Author 2015. Published by Oxford University Press.

The associations between adult attachment, posttraumatic symptoms, and posttraumatic growth.

PubMed

Arikan, Gizem; Stopa, Lusia; Carnelley, Katherine B; Karl, Anke

2016-01-01

Individual differences after trauma vary considerably and can range from posttraumatic stress disorder (PTSD) to posttraumatic growth (PTG). Current theoretical models cannot fully explain this variability. Therefore, we integrated attachment theory with Ehlers and Clark's model of PTSD to understand whether attachment style is associated with negative appraisals of a traumatic event(s), posttraumatic stress symptoms (PTS), and PTG. Our aim was to test this integrated model PTSD in an analog sample who had experienced at least one traumatic event. We used structural equation modeling to test the association of adult attachment and posttraumatic cognitions (self and world/others) with PTS and PTG using a cross-sectional, correlational design. The sample comprised 393 university staff and students (RangeAge= 18-49, 85% females) who completed online measures. Attachment anxiety and negative posttraumatic self-cognitions were positively associated. Negative posttraumatic self-cognitions were positively associated with PTS. Attachment anxiety had an indirect effect (via negative posttraumatic self-cognitions) on PTS, whereas attachment avoidance predicted more negative posttraumatic world cognitions and lower perceived PTG. The study highlights the importance of considering how attachment styles influence posttraumatic emotion regulation and cognitive processing of the trauma to determine posttraumatic mental health.

Are the Literacy Difficulties That Characterize Developmental Dyslexia Associated with a Failure to Integrate Letters and Speech Sounds?

ERIC Educational Resources Information Center

Nash, Hannah M.; Gooch, Debbie; Hulme, Charles; Mahajan, Yatin; McArthur, Genevieve; Steinmetzger, Kurt; Snowling, Margaret J.

2017-01-01

The "automatic letter-sound integration hypothesis" (Blomert, [Blomert, L., 2011]) proposes that dyslexia results from a failure to fully integrate letters and speech sounds into automated audio-visual objects. We tested this hypothesis in a sample of English-speaking children with dyslexic difficulties (N = 13) and samples of…

Identifying Discriminating Variables between Teachers Who Fully Integrate Computers and Teachers with Limited Integration

ERIC Educational Resources Information Center

Mueller, Julie; Wood, Eileen; Willoughby, Teena; Ross, Craig; Specht, Jacqueline

2008-01-01

Given the prevalence of computers in education today, it is critical to understand teachers' perspectives regarding computer integration in their classrooms. The current study surveyed a random sample of a heterogeneous group of 185 elementary and 204 secondary teachers in order to provide a comprehensive summary of teacher characteristics and…

GIS model-based real-time hydrological forecasting and operation management system for the Lake Balaton and its watershed

NASA Astrophysics Data System (ADS)

Adolf Szabó, János; Zoltán Réti, Gábor; Tóth, Tünde

2017-04-01

Today, the most significant mission of the decision makers on integrated water management issues is to carry out sustainable management for sharing the resources between a variety of users and the environment under conditions of considerable uncertainty (such as climate/land-use/population/etc. change) conditions. In light of this increasing water management complexity, we consider that the most pressing needs is to develop and implement up-to-date GIS model-based real-time hydrological forecasting and operation management systems for aiding decision-making processes to improve water management. After years of researches and developments the HYDROInform Ltd. has developed an integrated, on-line IT system (DIWA-HFMS: DIstributed WAtershed - Hydrologyc Forecasting & Modelling System) which is able to support a wide-ranging of the operational tasks in water resources management such as: forecasting, operation of lakes and reservoirs, water-control and management, etc. Following a test period, the DIWA-HFMS has been implemented for the Lake Balaton and its watershed (in 500 m resolution) at Central-Transdanubian Water Directorate (KDTVIZIG). The significant pillars of the system are: - The DIWA (DIstributed WAtershed) hydrologic model, which is a 3D dynamic water-balance model that distributed both in space and its parameters, and which was developed along combined principles but its mostly based on physical foundations. The DIWA integrates 3D soil-, 2D surface-, and 1D channel-hydraulic components as well. - Lakes and reservoir-operating component; - Radar-data integration module; - fully online data collection tools; - scenario manager tool to create alternative scenarios, - interactive, intuitive, highly graphical user interface. In Vienna, the main functions, operations and results-management of the system will be presented.

Asymptotic analysis of discrete schemes for non-equilibrium radiation diffusion

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cui, Xia, E-mail: cui_xia@iapcm.ac.cn; Yuan, Guang-wei; Shen, Zhi-jun

Motivated by providing well-behaved fully discrete schemes in practice, this paper extends the asymptotic analysis on time integration methods for non-equilibrium radiation diffusion in [2] to space discretizations. Therein studies were carried out on a two-temperature model with Larsen's flux-limited diffusion operator, both the implicitly balanced (IB) and linearly implicit (LI) methods were shown asymptotic-preserving. In this paper, we focus on asymptotic analysis for space discrete schemes in dimensions one and two. First, in construction of the schemes, in contrast to traditional first-order approximations, asymmetric second-order accurate spatial approximations are devised for flux-limiters on boundary, and discrete schemes with second-ordermore » accuracy on global spatial domain are acquired consequently. Then by employing formal asymptotic analysis, the first-order asymptotic-preserving property for these schemes and furthermore for the fully discrete schemes is shown. Finally, with the help of manufactured solutions, numerical tests are performed, which demonstrate quantitatively the fully discrete schemes with IB time evolution indeed have the accuracy and asymptotic convergence as theory predicts, hence are well qualified for both non-equilibrium and equilibrium radiation diffusion. - Highlights: • Provide AP fully discrete schemes for non-equilibrium radiation diffusion. • Propose second order accurate schemes by asymmetric approach for boundary flux-limiter. • Show first order AP property of spatially and fully discrete schemes with IB evolution. • Devise subtle artificial solutions; verify accuracy and AP property quantitatively. • Ideas can be generalized to 3-dimensional problems and higher order implicit schemes.« less

Numerical Approach to Spatial Deterministic-Stochastic Models Arising in Cell Biology

PubMed Central

Gao, Fei; Li, Ye; Novak, Igor L.; Slepchenko, Boris M.

2016-01-01

Hybrid deterministic-stochastic methods provide an efficient alternative to a fully stochastic treatment of models which include components with disparate levels of stochasticity. However, general-purpose hybrid solvers for spatially resolved simulations of reaction-diffusion systems are not widely available. Here we describe fundamentals of a general-purpose spatial hybrid method. The method generates realizations of a spatially inhomogeneous hybrid system by appropriately integrating capabilities of a deterministic partial differential equation solver with a popular particle-based stochastic simulator, Smoldyn. Rigorous validation of the algorithm is detailed, using a simple model of calcium ‘sparks’ as a testbed. The solver is then applied to a deterministic-stochastic model of spontaneous emergence of cell polarity. The approach is general enough to be implemented within biologist-friendly software frameworks such as Virtual Cell. PMID:27959915

Calculation of transient potential rise on the wind turbine struck by lightning.

PubMed

Xiaoqing, Zhang

2014-01-01

A circuit model is proposed in this paper for calculating the transient potential rise on the wind turbine struck by lightning. The model integrates the blade, sliding contact site, and tower and grounding system of the wind turbine into an equivalent circuit. The lightning current path from the attachment point to the ground can be fully described by the equivalent circuit. The transient potential responses are obtained in the different positions on the wind turbine by solving the circuit equations. In order to check the validity of the model, the laboratory measurement is made with a reduced-scale wind turbine. The measured potential waveform is compared with the calculated one and a better agreement is shown between them. The practical applicability of the model is also examined by a numerical example of a 2 MW Chinese-built wind turbine.

Viscoelastic tides: models for use in Celestial Mechanics

NASA Astrophysics Data System (ADS)

Ragazzo, C.; Ruiz, L. S.

2017-05-01

This paper contains equations for the motion of linear viscoelastic bodies interacting under gravity. The equations are fully three dimensional and allow for the integration of the spin, the orbit, and the deformation of each body. The goal is to present good models for the tidal forces that take into account the possibly different rheology of each body. The equations are obtained within a finite dimension Lagrangian framework with dissipation function. The main contribution is a procedure to associate to each spring-dashpot model, which defines the rheology of a body, a potential and a dissipation function for the body deformation variables. The theory is applied to the Earth (solid part plus oceans) and a comparison between model and observation of the following quantities is made: norm of the Love numbers, rate of tidal energy dissipation, Chandler period, and Earth-Moon distance increase.

Sixth-Order Lie Group Integrators

DOE Office of Scientific and Technical Information (OSTI.GOV)

Forest, E.

1990-03-01

In this paper we present the coefficients of several 6th order symplectic integrator of the type developed by R. Ruth. To get these results we fully exploit the connection with Lie groups. This integrator, as well as all the explicit integrators of Ruth, may be used in any equation where some sort of Lie bracket is preserved. In fact, if the Lie operator governing the equation of motion is separable into two solvable parts, the Ruth integrators can be used.

The UIST image slicing integral field unit

NASA Astrophysics Data System (ADS)

Ramsay Howat, S.; Todd, S.; Wells, M.; Hastings, P.

2006-06-01

The UKIRT Imager Spectrometer (UIST) contains a deployable integral field unit which is one of the most popular modes of this common-user instrument. In this paper, we review all aspects of the UIST IFU from the design and production of the aluminium mirrors to the integration with the telescope system during commissioning. Reduction of the integral field data is fully supported by the UKIRT data reduction pipeline, ORAC-DR.

U.S. Movements of Crude Oil By Rail

EIA Publications

2017-01-01

U.S. Movements of Crude Oil By Rail includes new data on crude oil transported by railroad. This product will fully integrate EIA's petroleum supply and disposition data along with pipeline, tanker, and barge data. Fully incorporating crude-by-rail movements improves EIA's regional petroleum balances by reducing regional crude oil adjustments (unaccounted for crude oil).

3D engineered cardiac tissue models of human heart disease: learning more from our mice.

PubMed

Ralphe, J Carter; de Lange, Willem J

2013-02-01

Mouse engineered cardiac tissue constructs (mECTs) are a new tool available to study human forms of genetic heart disease within the laboratory. The cultured strips of cardiac cells generate physiologic calcium transients and twitch force, and respond to electrical pacing and adrenergic stimulation. The mECT can be made using cells from existing mouse models of cardiac disease, providing a robust readout of contractile performance and allowing a rapid assessment of genotype-phenotype correlations and responses to therapies. mECT represents an efficient and economical extension to the existing tools for studying cardiac physiology. Human ECTs generated from iPSCMs represent the next logical step for this technology and offer significant promise of an integrated, fully human, cardiac tissue model. Copyright © 2013. Published by Elsevier Inc.

Does cultural integration explain a mental health advantage for adolescents?

PubMed

Bhui, Kamaldeep S; Lenguerrand, Erik; Maynard, Maria J; Stansfeld, Stephen A; Harding, Seeromanie

2012-06-01

A mental health advantage has been observed among adolescents in urban areas. This prospective study tests whether cultural integration measured by cross-cultural friendships explains a mental health advantage for adolescents. A prospective cohort of adolescents was recruited from 51 secondary schools in 10 London boroughs. Cultural identity was assessed by friendship choices within and across ethnic groups. Cultural integration is one of four categories of cultural identity. Using gender-specific linear-mixed models we tested whether cultural integration explained a mental health advantage, and whether gender and age were influential. Demographic and other relevant factors, such as ethnic group, socio-economic status, family structure, parenting styles and perceived racism were also measured and entered into the models. Mental health was measured by the Strengths and Difficulties Questionnaire as a 'total difficulties score' and by classification as a 'probable clinical case'. A total of 6643 pupils in first and second years of secondary school (ages 11-13 years) took part in the baseline survey (2003/04) and 4785 took part in the follow-up survey in 2005-06. Overall mental health improved with age, more so in male rather than female students. Cultural integration (friendships with own and other ethnic groups) was associated with the lowest levels of mental health problems especially among male students. This effect was sustained irrespective of age, ethnicity and other potential explanatory variables. There was a mental health advantage among specific ethnic groups: Black Caribbean and Black African male students (Nigerian/Ghanaian origin) and female Indian students. This was not fully explained by cultural integration, although cultural integration was independently associated with better mental health. Cultural integration was associated with better mental health, independent of the mental health advantage found among specific ethnic groups: Black Caribbean and some Black African male students and female Indian students.

Physically-Based Assessment of Intrinsic Groundwater Resource Vulnerability in AN Urban Catchment

NASA Astrophysics Data System (ADS)

Graf, T.; Therrien, R.; Lemieux, J.; Molson, J. W.

2013-12-01

Several methods exist to assess intrinsic groundwater (re)source vulnerability for the purpose of sustainable groundwater management and protection. However, several methods are empirical and limited in their application to specific types of hydrogeological systems. Recent studies suggest that a physically-based approach could be better suited to provide a general, conceptual and operational basis for groundwater vulnerability assessment. A novel method for physically-based assessment of intrinsic aquifer vulnerability is currently under development and tested to explore the potential of an integrated modelling approach, combining groundwater travel time probability and future scenario modelling in conjunction with the fully integrated HydroGeoSphere model. To determine the intrinsic groundwater resource vulnerability, a fully coupled 2D surface water and 3D variably-saturated groundwater flow model in conjunction with a 3D geological model (GoCAD) has been developed for a case study of the Rivière Saint-Charles (Québec/Canada) regional scale, urban watershed. The model has been calibrated under transient flow conditions for the hydrogeological, variably-saturated subsurface system, coupled with the overland flow zone by taking into account monthly recharge variation and evapotranspiration. To better determine the intrinsic groundwater vulnerability, two independent approaches are considered and subsequently combined in a simple, holistic multi-criteria-decision analyse. Most data for the model comes from an extensive hydrogeological database for the watershed, whereas data gaps have been complemented via field tests and literature review. The subsurface is composed of nine hydrofacies, ranging from unconsolidated fluvioglacial sediments to low permeability bedrock. The overland flow zone is divided into five major zones (Urban, Rural, Forest, River and Lake) to simulate the differences in landuse, whereas the unsaturated zone is represented via the model integrated Van-Genuchten function. The model setup and optimisation turn out to be the most challenging part because of the non-trivial nature (due to the highly non-linear PDEs) of the coupling procedure between the surface and subsurface domain, while keeping realistic parameter ranges and obtaining realistic simulation results in both domains. The model calibration is based on water level monitoring as well as daily mean river discharge measurement at different gauge stations within the catchment. It is intended to create multiple model outcomes for the numerical modelling of the groundwater vulnerability to take into account uncertainty due to the model input data. The next step of the overall vulnerability assessment consists in modelling future vulnerability scenario(s), applying realistic changes to the model by using PEST with SENSAN for subsequent sensitivity analysis. The PEST model could also potentially be used for a model recalibration as a function of the model parameters sensitivity (simple perturbation method). Preliminary results showing a good fit between the observed and simulated water levels and hydrographs. However the simulated water depth at the overland flow domain as well as the simulated saturation distribution in the porous media domain are still showing room for improvement of the numerical model.

Computer simulation models as a tool to investigate the role of microRNAs in osteoarthritis

PubMed Central

Smith, Graham R.

2017-01-01

The aim of this study was to show how computational models can be used to increase our understanding of the role of microRNAs in osteoarthritis (OA) using miR-140 as an example. Bioinformatics analysis and experimental results from the literature were used to create and calibrate models of gene regulatory networks in OA involving miR-140 along with key regulators such as NF-κB, SMAD3, and RUNX2. The individual models were created with the modelling standard, Systems Biology Markup Language, and integrated to examine the overall effect of miR-140 on cartilage homeostasis. Down-regulation of miR-140 may have either detrimental or protective effects for cartilage, indicating that the role of miR-140 is complex. Studies of individual networks in isolation may therefore lead to different conclusions. This indicated the need to combine the five chosen individual networks involving miR-140 into an integrated model. This model suggests that the overall effect of miR-140 is to change the response to an IL-1 stimulus from a prolonged increase in matrix degrading enzymes to a pulse-like response so that cartilage degradation is temporary. Our current model can easily be modified and extended as more experimental data become available about the role of miR-140 in OA. In addition, networks of other microRNAs that are important in OA could be incorporated. A fully integrated model could not only aid our understanding of the mechanisms of microRNAs in ageing cartilage but could also provide a useful tool to investigate the effect of potential interventions to prevent cartilage loss. PMID:29095952

Hybrid Environmental Control System Integrated Modeling Trade Study Analysis for Commercial Aviation

NASA Astrophysics Data System (ADS)

Parrilla, Javier

Current industry trends demonstrate aircraft electrification will be part of future platforms in order to achieve higher levels of efficiency in various vehicle level sub-systems. However electrification requires a substantial change in aircraft design that is not suitable for re-winged or re-engined applications as some aircraft manufacturers are opting for today. Thermal limits arise as engine cores progressively get smaller and hotter to improve overall engine efficiency, while legacy systems still demand a substantial amount of pneumatic, hydraulic and electric power extraction. The environmental control system (ECS) provides pressurization, ventilation and air conditioning in commercial aircraft, making it the main heat sink for all aircraft loads with exception of the engine. To mitigate the architecture thermal limits in an efficient manner, the form in which the ECS interacts with the engine will have to be enhanced as to reduce the overall energy consumed and achieve an energy optimized solution. This study examines a tradeoff analysis of an electric ECS by use of a fully integrated Numerical Propulsion Simulation System (NPSS) model that is capable of studying the interaction between the ECS and the engine cycle deck. It was found that a peak solution lays in a hybrid ECS where it utilizes the correct balance between a traditional pneumatic and a fully electric system. This intermediate architecture offers a substantial improvement in aircraft fuel consumptions due to a reduced amount of waste heat and customer bleed in exchange for partial electrification of the air-conditions pack which is a viable option for re-winged applications.

Dynamic coupling of three hydrodynamic models

NASA Astrophysics Data System (ADS)

Hartnack, J. N.; Philip, G. T.; Rungoe, M.; Smith, G.; Johann, G.; Larsen, O.; Gregersen, J.; Butts, M. B.

2008-12-01

The need for integrated modelling is evidently present within the field of flood management and flood forecasting. Engineers, modellers and managers are faced with flood problems which transcend the classical hydrodynamic fields of urban, river and coastal flooding. Historically the modeller has been faced with having to select one hydrodynamic model to cover all the aspects of the potentially complex dynamics occurring in a flooding situation. Such a single hydrodynamic model does not cover all dynamics of flood modelling equally well. Thus the ideal choice may in fact be a combination of models. Models combining two numerical/hydrodynamic models are becoming more standard, typically these models combine a 1D river model with a 2D overland flow model or alternatively a 1D sewer/collection system model with a 2D overland solver. In complex coastal/urban areas the flood dynamics may include rivers/streams, collection/storm water systems along with the overland flow. The dynamics within all three areas is of the same time scale and there is feedback in the system across the couplings. These two aspects dictate a fully dynamic three way coupling as opposed to running the models sequentially. It will be shown that the main challenges of the three way coupling are time step issues related to the difference in numerical schemes used in the three model components and numerical instabilities caused by the linking of the model components. MIKE FLOOD combines the models MIKE 11, MIKE 21 and MOUSE into one modelling framework which makes it possible to couple any combination of river, urban and overland flow fully dynamically. The MIKE FLOOD framework will be presented with an overview of the coupling possibilities. The flood modelling concept will be illustrated through real life cases in Australia and in Germany. The real life cases reflect dynamics and interactions across all three model components which are not possible to reproduce using a two-way coupling alone. The models comprise 2D inundation modelling, river networks with multiple structures (pumps, weirs, culverts), urban drainage networks as well as dam break modelling. The models were used to quantify the results of storm events or failures (dam break, pumping failures etc) coinciding with high discharge in river system and heavy rainfall. The detailed representation of the flow path through the city allowed a direct assessment of flood risk Thus it is found that the three-way coupled model is a practical and useful tool for integrated flood management.

Service-oriented model-encapsulation strategy for sharing and integrating heterogeneous geo-analysis models in an open web environment

NASA Astrophysics Data System (ADS)

Yue, Songshan; Chen, Min; Wen, Yongning; Lu, Guonian

2016-04-01

Earth environment is extremely complicated and constantly changing; thus, it is widely accepted that the use of a single geo-analysis model cannot accurately represent all details when solving complex geo-problems. Over several years of research, numerous geo-analysis models have been developed. However, a collaborative barrier between model providers and model users still exists. The development of cloud computing has provided a new and promising approach for sharing and integrating geo-analysis models across an open web environment. To share and integrate these heterogeneous models, encapsulation studies should be conducted that are aimed at shielding original execution differences to create services which can be reused in the web environment. Although some model service standards (such as Web Processing Service (WPS) and Geo Processing Workflow (GPW)) have been designed and developed to help researchers construct model services, various problems regarding model encapsulation remain. (1) The descriptions of geo-analysis models are complicated and typically require rich-text descriptions and case-study illustrations, which are difficult to fully represent within a single web request (such as the GetCapabilities and DescribeProcess operations in the WPS standard). (2) Although Web Service technologies can be used to publish model services, model users who want to use a geo-analysis model and copy the model service into another computer still encounter problems (e.g., they cannot access the model deployment dependencies information). This study presents a strategy for encapsulating geo-analysis models to reduce problems encountered when sharing models between model providers and model users and supports the tasks with different web service standards (e.g., the WPS standard). A description method for heterogeneous geo-analysis models is studied. Based on the model description information, the methods for encapsulating the model-execution program to model services and for describing model-service deployment information are also included in the proposed strategy. Hence, the model-description interface, model-execution interface and model-deployment interface are studied to help model providers and model users more easily share, reuse and integrate geo-analysis models in an open web environment. Finally, a prototype system is established, and the WPS standard is employed as an example to verify the capability and practicability of the model-encapsulation strategy. The results show that it is more convenient for modellers to share and integrate heterogeneous geo-analysis models in cloud computing platforms.

Integrated Glass Coating Manufacturing Line

DOE Office of Scientific and Technical Information (OSTI.GOV)

Brophy, Brenor

2015-09-30

This project aims to enable US module manufacturers to coat glass with Enki’s state of the art tunable functionalized AR coatings at the lowest possible cost and highest possible performance by encapsulating Enki’s coating process in an integrated tool that facilitates effective process improvement through metrology and data analysis for greater quality and performance while reducing footprint, operating and capital costs. The Phase 1 objective was a fully designed manufacturing line, including fully specified equipment ready for issue of purchase requisitions; a detailed economic justification based on market prices at the end of Phase 1 and projected manufacturing costs andmore » a detailed deployment plan for the equipment.« less

Long term in vitro stability of fully integrated wireless neural interfaces based on Utah slant electrode array

NASA Astrophysics Data System (ADS)

Sharma, Asha; Rieth, Loren; Tathireddy, Prashant; Harrison, Reid; Solzbacher, Florian

2010-02-01

We herein report in vitro functional stability and recording longevity of a fully integrated wireless neural interface (INI). The INI uses biocompatible Parylene-C as an encapsulation layer, and was immersed in phosphate buffered saline (PBS) for a period of over 150 days. The full functionality (wireless radio-frequency power, command, and signal transmission) and the ability of INI to record artificial action potentials even after 150 days of PBS soaking without any change in signal/noise amplitude constitutes a major milestone in long term stability, and evaluate the encapsulation reliability, functional stability, and potential usefulness for future chronic implants.

River Inflows into Lakes: Basin Temperature Profiles Driven By Peeling Detrainment from Dense Underflows

NASA Astrophysics Data System (ADS)

Hogg, C. A. R.; Huppert, H. E.; Imberger, J.; Dalziel, S. B.

2014-12-01

Dense gravity currents from river inflows feed fluid into confined basins in lakes. Large inflows can influence temperature profiles in the basins. Existing parameterisations of the circulation and mixing of such inflows are often based on the entrainment of ambient fluid into the underflowing gravity currents. However, recent observations have suggested that uni-directional entrainment into a gravity current does not fully describe the transfer between such gravity currents and the ambient water. Laboratory experiments visualised peeling detrainment from the gravity current occurring when the ambient fluid was stratified. A theoretical model of the observed peeling detrainment was developed to predict the temperature profile in the basin. This new model gives a better approximation of the temperature profile observed in the experiments than the pre-existing entraining model. The model can now be developed such that it integrates into operational models of lake basins.

Search for new resonances decaying via WZ to leptons in proton–proton collisions at $$\\sqrt s =$$ 8 TeV

DOE PAGES

Khachatryan, V.

2014-11-18

A search is performed in proton–proton collisions at √s=8 TeV for exotic particles decaying via WZ to fully leptonic final states with electrons, muons, and neutrinos. The data set corresponds to an integrated luminosity of 19.5 fb -1. No significant excess is observed above the expected standard model background. Upper bounds at 95% confidence level are set on the production cross section of a W' boson as predicted by an extended gauge model, and on the W'WZ coupling. The expected and observed mass limits for a W' boson, as predicted by this model, are 1.55 and 1.47 TeV, respectively. Stringentmore » limits are also set in the context of low-scale technicolor models under a range of assumptions for the model parameters.« less

Space-based Doppler lidar sampling strategies: Algorithm development and simulated observation experiments

NASA Technical Reports Server (NTRS)

Emmitt, G. D.; Wood, S. A.; Morris, M.

1990-01-01

Lidar Atmospheric Wind Sounder (LAWS) Simulation Models (LSM) were developed to evaluate the potential impact of global wind observations on the basic understanding of the Earth's atmosphere and on the predictive skills of current forecast models (GCM and regional scale). Fully integrated top to bottom LAWS Simulation Models for global and regional scale simulations were developed. The algorithm development incorporated the effects of aerosols, water vapor, clouds, terrain, and atmospheric turbulence into the models. Other additions include a new satellite orbiter, signal processor, line of sight uncertainty model, new Multi-Paired Algorithm and wind error analysis code. An atmospheric wind field library containing control fields, meteorological fields, phenomena fields, and new European Center for Medium Range Weather Forecasting (ECMWF) data was also added. The LSM was used to address some key LAWS issues and trades such as accuracy and interpretation of LAWS information, data density, signal strength, cloud obscuration, and temporal data resolution.

Application of Simulated Reactivity Feedback in Nonnuclear Testing of a Direct-Drive Gas-Cooled Reactor

NASA Technical Reports Server (NTRS)

Bragg-Sitton, S. M.; Webster, K. L.

2007-01-01

Nonnuclear testing can be a valuable tool in the development of an in-space nuclear power or propulsion system. In a nonnuclear test facility, electric heaters are used to simulate heat from nuclear fuel. Standard testing allows one to fully assess thermal, heat transfer, and stress related attributes of a given system but fails to demonstrate the dynamic response that would be present in an integrated, fueled reactor system. The integration of thermal hydraulic hardware tests with simulated neutronic response provides a bridge between electrically heated testing and full nuclear testing. By implementing a neutronic response model to simulate the dynamic response that would be expected in a fueled reactor system, one can better understand system integration issues, characterize integrated system response times and response and response characteristics, and assess potential design improvements with a relatively small fiscal investment. Initial system dynamic response testing was demonstrated on the integrated SAFE 100a heat pipe cooled, electrically heated reactor and heat exchanger hardware. This Technical Memorandum discusses the status of the planned dynamic test methodology for implementation in the direct-drive gas-cooled reactor testing and assesses the additional instrumentation needed to implement high-fidelity dynamic testing.

Modeling of Kerena Emergency Condenser

NASA Astrophysics Data System (ADS)

Bryk, Rafał; Schmidt, Holger; Mull, Thomas; Wagner, Thomas; Ganzmann, Ingo; Herbst, Oliver

2017-12-01

KERENA is an innovative boiling water reactor concept equipped with several passive safety systems. For the experimental verification of performance of the systems and for codes validation, the Integral Test Stand Karlstein (INKA) was built in Karlstein, Germany. The emergency condenser (EC) system transfers heat from the reactor pressure vessel (RPV) to the core flooding pool in case of water level decrease in the RPV. EC is composed of a large number of slightly inclined tubes. During accident conditions, steam enters into the tubes and condenses due to the contact of the tubes with cold water at the secondary side. The condensed water flows then back to the RPV due to gravity. In this paper two approaches for modeling of condensation in slightly inclined tubes are compared and verified against experiments. The first approach is based on the flow regime map. Depending on the regime, heat transfer coefficient is calculated according to specific semi-empirical correlation. The second approach uses a general, fully-empirical correlation. The models are developed with utilization of the object-oriented Modelica language and the open-source OpenModelica environment. The results are compared with data obtained during a large scale integral test, simulating loss of coolant accident performed at Integral Test Stand Karlstein (INKA). The comparison shows a good agreement.Due to the modularity of models, both of them may be used in the future in systems incorporating condensation in horizontal or slightly inclined tubes. Depending on his preferences, the modeller may choose one-equation based approach or more sophisticated model composed of several exchangeable semi-empirical correlations.

Self-consistent Bulge/Disk/Halo Galaxy Dynamical Modeling Using Integral Field Kinematics

NASA Astrophysics Data System (ADS)

Taranu, D. S.; Obreschkow, D.; Dubinski, J. J.; Fogarty, L. M. R.; van de Sande, J.; Catinella, B.; Cortese, L.; Moffett, A.; Robotham, A. S. G.; Allen, J. T.; Bland-Hawthorn, J.; Bryant, J. J.; Colless, M.; Croom, S. M.; D'Eugenio, F.; Davies, R. L.; Drinkwater, M. J.; Driver, S. P.; Goodwin, M.; Konstantopoulos, I. S.; Lawrence, J. S.; López-Sánchez, Á. R.; Lorente, N. P. F.; Medling, A. M.; Mould, J. R.; Owers, M. S.; Power, C.; Richards, S. N.; Tonini, C.

2017-11-01

We introduce a method for modeling disk galaxies designed to take full advantage of data from integral field spectroscopy (IFS). The method fits equilibrium models to simultaneously reproduce the surface brightness, rotation, and velocity dispersion profiles of a galaxy. The models are fully self-consistent 6D distribution functions for a galaxy with a Sérsic profile stellar bulge, exponential disk, and parametric dark-matter halo, generated by an updated version of GalactICS. By creating realistic flux-weighted maps of the kinematic moments (flux, mean velocity, and dispersion), we simultaneously fit photometric and spectroscopic data using both maximum-likelihood and Bayesian (MCMC) techniques. We apply the method to a GAMA spiral galaxy (G79635) with kinematics from the SAMI Galaxy Survey and deep g- and r-band photometry from the VST-KiDS survey, comparing parameter constraints with those from traditional 2D bulge-disk decomposition. Our method returns broadly consistent results for shared parameters while constraining the mass-to-light ratios of stellar components and reproducing the H I-inferred circular velocity well beyond the limits of the SAMI data. Although the method is tailored for fitting integral field kinematic data, it can use other dynamical constraints like central fiber dispersions and H I circular velocities, and is well-suited for modeling galaxies with a combination of deep imaging and H I and/or optical spectra (resolved or otherwise). Our implementation (MagRite) is computationally efficient and can generate well-resolved models and kinematic maps in under a minute on modern processors.

A two-channel, spectrally degenerate polarization entangled source on chip

NASA Astrophysics Data System (ADS)

Sansoni, Linda; Luo, Kai Hong; Eigner, Christof; Ricken, Raimund; Quiring, Viktor; Herrmann, Harald; Silberhorn, Christine

2017-12-01

Integrated optics provides the platform for the experimental implementation of highly complex and compact circuits for quantum information applications. In this context integrated waveguide sources represent a powerful resource for the generation of quantum states of light due to their high brightness and stability. However, the confinement of the light in a single spatial mode limits the realization of multi-channel sources. Due to this challenge one of the most adopted sources in quantum information processes, i.e. a source which generates spectrally indistinguishable polarization entangled photons in two different spatial modes, has not yet been realized in a fully integrated platform. Here we overcome this limitation by suitably engineering two periodically poled waveguides and an integrated polarization splitter in lithium niobate. This source produces polarization entangled states with fidelity of F = 0.973 ±0.003 and a test of Bell's inequality results in a violation larger than 14 standard deviations. It can work both in pulsed and continuous wave regime. This device represents a new step toward the implementation of fully integrated circuits for quantum information applications.

An End-To-End Test of A Simulated Nuclear Electric Propulsion System

NASA Technical Reports Server (NTRS)

VanDyke, Melissa; Hrbud, Ivana; Goddfellow, Keith; Rodgers, Stephen L. (Technical Monitor)

2002-01-01

The Safe Affordable Fission Engine (SAFE) test series addresses Phase I Space Fission Systems issues in it particular non-nuclear testing and system integration issues leading to the testing and non-nuclear demonstration of a 400-kW fully integrated flight unit. The first part of the SAFE 30 test series demonstrated operation of the simulated nuclear core and heat pipe system. Experimental data acquired in a number of different test scenarios will validate existing computational models, demonstrated system flexibility (fast start-ups, multiple start-ups/shut downs), simulate predictable failure modes and operating environments. The objective of the second part is to demonstrate an integrated propulsion system consisting of a core, conversion system and a thruster where the system converts thermal heat into jet power. This end-to-end system demonstration sets a precedent for ground testing of nuclear electric propulsion systems. The paper describes the SAFE 30 end-to-end system demonstration and its subsystems.

Measurement of the Boltzmann constant by Johnson noise thermometry using a superconducting integrated circuit

NASA Astrophysics Data System (ADS)

Urano, C.; Yamazawa, K.; Kaneko, N.-H.

2017-12-01

We report on our measurement of the Boltzmann constant by Johnson noise thermometry (JNT) using an integrated quantum voltage noise source (IQVNS) that is fully implemented with superconducting integrated circuit technology. The IQVNS generates calculable pseudo white noise voltages to calibrate the JNT system. The thermal noise of a sensing resistor placed at the temperature of the triple point of water was measured precisely by the IQVNS-based JNT. We accumulated data of more than 429 200 s in total (over 6 d) and used the Akaike information criterion to estimate the fitting frequency range for the quadratic model to calculate the Boltzmann constant. Upon detailed evaluation of the uncertainty components, the experimentally obtained Boltzmann constant was k=1.380 6436× {{10}-23} J K-1 with a relative combined uncertainty of 10.22× {{10}-6} . The value of k is relatively -3.56× {{10}-6} lower than the CODATA 2014 value (Mohr et al 2016 Rev. Mod. Phys. 88 035009).

End-to-End Demonstrator of the Safe Affordable Fission Engine (SAFE) 30: Power Conversion and Ion Engine Operation

NASA Technical Reports Server (NTRS)

Hrbud, Ivana; VanDyke, Melissa; Houts, Mike; Goodfellow, Keith; Schafer, Charles (Technical Monitor)

2001-01-01

The Safe Affordable Fission Engine (SAFE) test series addresses Phase 1 Space Fission Systems issues in particular non-nuclear testing and system integration issues leading to the testing and non-nuclear demonstration of a 400-kW fully integrated flight unit. The first part of the SAFE 30 test series demonstrated operation of the simulated nuclear core and heat pipe system. Experimental data acquired in a number of different test scenarios will validate existing computational models, demonstrated system flexibility (fast start-ups, multiple start-ups/shut downs), simulate predictable failure modes and operating environments. The objective of the second part is to demonstrate an integrated propulsion system consisting of a core, conversion system and a thruster where the system converts thermal heat into jet power. This end-to-end system demonstration sets a precedent for ground testing of nuclear electric propulsion systems. The paper describes the SAFE 30 end-to-end system demonstration and its subsystems.

Research Integrity and Peer Review-past highlights and future directions.

PubMed

Boughton, Stephanie L; Kowalczuk, Maria K; Meerpohl, Joerg J; Wager, Elizabeth; Moylan, Elizabeth C

2018-01-01

In May 2016, we launched Research Integrity and Peer Review , an international, open access journal with fully open peer review (reviewers are identified on their reports and named reports are published alongside the article) to provide a home for research on research and publication ethics, research reporting, and research on peer review. As the journal enters its third year, we reflect on recent events and highlights for the journal and explore how the journal is faring in terms of gender and diversity in peer review. We also share the particular interests of our Editors-in-Chief regarding models of peer review, reporting quality, common research integrity issues that arise during the publishing process, and how people interact with the published literature. We continue to encourage further research into peer review, research and publication ethics and research reporting, as we believe that all new initiatives should be evidence-based. We also remain open to constructive discussions of the developments in the field that offer new solutions.

Resilience mediated the association between acculturation and psychological growth in college students from Hong Kong to Guangzhou, China.

PubMed

Yu, Nancy Xiaonan; Liu, Chang; Yue, Zhenzhu

2017-08-01

The number of Hong Kong citizens living in mainland China is increasing. The process of acculturation may create opportunities for psychological growth. This study aimed at examining whether resilience mediated the effects of acculturation on psychological growth in college students from Hong Kong to Guangzhou. In this cross-sectional survey, 164 college students in Guangzhou who were Hong Kong permanent residents (female: 46%, age: 21.09 ± 1.50) joined the study. The integration group reported more psychological growth than the assimilation, separation, and marginalization groups. Resilience partially mediated the effect of integration on psychological growth and fully mediated the effect of marginalization on psychological growth. Resilience represents one of the mechanisms to explain beneficial effects of integration on psychological growth in college students from Hong Kong to Guangzhou. Theoretical considerations to rethink the acculturation model, implications for developing intervention programs, and recommendations for future research are discussed.

Qualitative evaluation of titanium implant integration into bone by diffraction enhanced imaging.

PubMed

Wagner, A; Sachse, A; Keller, M; Aurich, M; Wetzel, W-D; Hortschansky, P; Schmuck, K; Lohmann, M; Reime, B; Metge, J; Arfelli, F; Menk, R; Rigon, L; Muehleman, C; Bravin, A; Coan, P; Mollenhauer, J

2006-03-07

Diffraction enhanced imaging (DEI) uses refraction of x-rays at edges, which allows pronounced visualization of material borders and rejects scattering which often obscures edges and blurs images. Here, the first evidence is presented that, using DEI, a destruction-free evaluation of the quality of integration of metal implants into bone is possible. Experiments were performed in rabbits and sheep with model implants to investigate the option for DEI as a tool in implant research. The results obtained from DEI were compared to conventional histology obtained from the specimens. DE images allow the identification of the quality of ingrowth of bone into the hydroxyapatite layer of the implant. Incomplete integration of the implant with a remaining gap of less than 0.3 mm caused the presence of a highly refractive edge at the implant/bone border. In contrast, implants with bone fully grown onto the surface did not display a refractive signal. Therefore, the refractive signal could be utilized to diagnose implant healing and/or loosening.

Qualitative evaluation of titanium implant integration into bone by diffraction enhanced imaging

NASA Astrophysics Data System (ADS)

Wagner, A.; Sachse, A.; Keller, M.; Aurich, M.; Wetzel, W.-D.; Hortschansky, P.; Schmuck, K.; Lohmann, M.; Reime, B.; Metge, J.; Arfelli, F.; Menk, R.; Rigon, L.; Muehleman, C.; Bravin, A.; Coan, P.; Mollenhauer, J.

2006-03-01

Diffraction enhanced imaging (DEI) uses refraction of x-rays at edges, which allows pronounced visualization of material borders and rejects scattering which often obscures edges and blurs images. Here, the first evidence is presented that, using DEI, a destruction-free evaluation of the quality of integration of metal implants into bone is possible. Experiments were performed in rabbits and sheep with model implants to investigate the option for DEI as a tool in implant research. The results obtained from DEI were compared to conventional histology obtained from the specimens. DE images allow the identification of the quality of ingrowth of bone into the hydroxyapatite layer of the implant. Incomplete integration of the implant with a remaining gap of less than 0.3 mm caused the presence of a highly refractive edge at the implant/bone border. In contrast, implants with bone fully grown onto the surface did not display a refractive signal. Therefore, the refractive signal could be utilized to diagnose implant healing and/or loosening.

Integrating Space Flight Resource Management Skills into Technical Lessons for International Space Station Flight Controller Training

NASA Technical Reports Server (NTRS)

Baldwin, Evelyn

2008-01-01

The Johnson Space Center s (JSC) International Space Station (ISS) Space Flight Resource Management (SFRM) training program is designed to teach the team skills required to be an effective flight controller. It was adapted from the SFRM training given to Shuttle flight controllers to fit the needs of a "24 hours a day/365 days a year" flight controller. More recently, the length reduction of technical training flows for ISS flight controllers impacted the number of opportunities for fully integrated team scenario based training, where most SFRM training occurred. Thus, the ISS SFRM training program is evolving yet again, using a new approach of teaching and evaluating SFRM alongside of technical materials. Because there are very few models in other industries that have successfully tied team and technical skills together, challenges are arising. Despite this, the Mission Operations Directorate of NASA s JSC is committed to implementing this integrated training approach because of the anticipated benefits.

Agent-Based Modeling of Mitochondria Links Sub-Cellular Dynamics to Cellular Homeostasis and Heterogeneity.

PubMed

Dalmasso, Giovanni; Marin Zapata, Paula Andrea; Brady, Nathan Ryan; Hamacher-Brady, Anne

2017-01-01

Mitochondria are semi-autonomous organelles that supply energy for cellular biochemistry through oxidative phosphorylation. Within a cell, hundreds of mobile mitochondria undergo fusion and fission events to form a dynamic network. These morphological and mobility dynamics are essential for maintaining mitochondrial functional homeostasis, and alterations both impact and reflect cellular stress states. Mitochondrial homeostasis is further dependent on production (biogenesis) and the removal of damaged mitochondria by selective autophagy (mitophagy). While mitochondrial function, dynamics, biogenesis and mitophagy are highly-integrated processes, it is not fully understood how systemic control in the cell is established to maintain homeostasis, or respond to bioenergetic demands. Here we used agent-based modeling (ABM) to integrate molecular and imaging knowledge sets, and simulate population dynamics of mitochondria and their response to environmental energy demand. Using high-dimensional parameter searches we integrated experimentally-measured rates of mitochondrial biogenesis and mitophagy, and using sensitivity analysis we identified parameter influences on population homeostasis. By studying the dynamics of cellular subpopulations with distinct mitochondrial masses, our approach uncovered system properties of mitochondrial populations: (1) mitochondrial fusion and fission activities rapidly establish mitochondrial sub-population homeostasis, and total cellular levels of mitochondria alter fusion and fission activities and subpopulation distributions; (2) restricting the directionality of mitochondrial mobility does not alter morphology subpopulation distributions, but increases network transmission dynamics; and (3) maintaining mitochondrial mass homeostasis and responding to bioenergetic stress requires the integration of mitochondrial dynamics with the cellular bioenergetic state. Finally, (4) our model suggests sources of, and stress conditions amplifying, cell-to-cell variability of mitochondrial morphology and energetic stress states. Overall, our modeling approach integrates biochemical and imaging knowledge, and presents a novel open-modeling approach to investigate how spatial and temporal mitochondrial dynamics contribute to functional homeostasis, and how subcellular organelle heterogeneity contributes to the emergence of cell heterogeneity.

Transport simulation of EAST long-pulse H-mode discharge with integrated modeling

NASA Astrophysics Data System (ADS)

Wu, M. Q.; Li, G. Q.; Chen, J. L.; Du, H. F.; Gao, X.; Ren, Q. L.; Li, K.; Chan, Vincent; Pan, C. K.; Ding, S. Y.; Jian, X.; Zhu, X.; Lian, H.; Qian, J. P.; Gong, X. Z.; Zang, Q.; Duan, Y. M.; Liu, H. Q.; Lyu, B.

2018-04-01

In the 2017 EAST experimental campaign, a steady-state long-pulse H-mode discharge lasting longer than 100 s has been obtained using only radio frequency heating and current drive, and the confinement quality is slightly better than standard H-mode, H98y2 ~ 1.1, with stationary peaked electron temperature profiles. Integrated modeling of one long-pulse H-mode discharge in the 2016 EAST experimental campaign has been performed with equilibrium code EFIT, and transport codes TGYRO and ONETWO under integrated modeling framework OMFIT. The plasma current is fully-noninductively driven with a combination of ~2.2 MW LHW, ~0.3 MW ECH and ~1.1 MW ICRF. Time evolution of the predicted electron and ion temperature profiles through integrated modeling agree closely with that from measurements. The plasma current (I p ~ 0.45 MA) and electron density are kept constantly. A steady-state is achieved using integrated modeling, and the bootstrap current fraction is ~28%, the RF drive current fraction is ~72%. The predicted current density profile matches the experimental one well. Analysis shows that electron cyclotron heating (ECH) makes large contribution to the plasma confinement when heating in the core region while heating in large radius does smaller improvement, also a more peaked LHW driven current profile is got when heating in the core. Linear analysis shows that the high-k modes instability (electron temperature gradient driven modes) is suppressed in the core region where exists weak electron internal transport barriers. The trapped electron modes dominates in the low-k region, which is mainly responsible for driving the electron energy flux. It is found that the ECH heating effect is very local and not the main cause to sustained the good confinement, the peaked current density profile has the most important effect on plasma confinement improvement. Transport analysis of the long-pulse H-mode experiments on EAST will be helpful to build future experiments.

Agent-Based Modeling of Mitochondria Links Sub-Cellular Dynamics to Cellular Homeostasis and Heterogeneity

PubMed Central

Dalmasso, Giovanni; Marin Zapata, Paula Andrea; Brady, Nathan Ryan; Hamacher-Brady, Anne

2017-01-01

Mitochondria are semi-autonomous organelles that supply energy for cellular biochemistry through oxidative phosphorylation. Within a cell, hundreds of mobile mitochondria undergo fusion and fission events to form a dynamic network. These morphological and mobility dynamics are essential for maintaining mitochondrial functional homeostasis, and alterations both impact and reflect cellular stress states. Mitochondrial homeostasis is further dependent on production (biogenesis) and the removal of damaged mitochondria by selective autophagy (mitophagy). While mitochondrial function, dynamics, biogenesis and mitophagy are highly-integrated processes, it is not fully understood how systemic control in the cell is established to maintain homeostasis, or respond to bioenergetic demands. Here we used agent-based modeling (ABM) to integrate molecular and imaging knowledge sets, and simulate population dynamics of mitochondria and their response to environmental energy demand. Using high-dimensional parameter searches we integrated experimentally-measured rates of mitochondrial biogenesis and mitophagy, and using sensitivity analysis we identified parameter influences on population homeostasis. By studying the dynamics of cellular subpopulations with distinct mitochondrial masses, our approach uncovered system properties of mitochondrial populations: (1) mitochondrial fusion and fission activities rapidly establish mitochondrial sub-population homeostasis, and total cellular levels of mitochondria alter fusion and fission activities and subpopulation distributions; (2) restricting the directionality of mitochondrial mobility does not alter morphology subpopulation distributions, but increases network transmission dynamics; and (3) maintaining mitochondrial mass homeostasis and responding to bioenergetic stress requires the integration of mitochondrial dynamics with the cellular bioenergetic state. Finally, (4) our model suggests sources of, and stress conditions amplifying, cell-to-cell variability of mitochondrial morphology and energetic stress states. Overall, our modeling approach integrates biochemical and imaging knowledge, and presents a novel open-modeling approach to investigate how spatial and temporal mitochondrial dynamics contribute to functional homeostasis, and how subcellular organelle heterogeneity contributes to the emergence of cell heterogeneity. PMID:28060865

Terrestrial Planet Finder Coronagraph Optical Modeling

NASA Technical Reports Server (NTRS)

Basinger, Scott A.; Redding, David C.

2004-01-01

The Terrestrial Planet Finder Coronagraph will rely heavily on modeling and analysis throughout its mission lifecycle. Optical modeling is especially important, since the tolerances on the optics as well as scattered light suppression are critical for the mission's success. The high contrast imaging necessary to observe a planet orbiting a distant star requires new and innovative technologies to be developed and tested, and detailed optical modeling provides predictions for evaluating design decisions. It also provides a means to develop and test algorithms designed to actively suppress scattered light via deformable mirrors and other techniques. The optical models are used in conjunction with structural and thermal models to create fully integrated optical/structural/thermal models that are used to evaluate dynamic effects of disturbances on the overall performance of the coronagraph. The optical models we have developed have been verified on the High Contrast Imaging Testbed. Results of the optical modeling verification and the methods used to perform full three-dimensional near-field diffraction analysis are presented.

Integrating Wind and Solar on the Grid-NREL Analysis Leads the Way -

Science.gov Websites

shown in color, but not including pink/IESO area.) Map provided by NREL Integrating Wind and Solar on the Grid-NREL Analysis Leads the Way NREL studies confirm big wind, solar potential for grid integration To fully harvest the nation's bountiful wind and solar resources, it is critical to know how much

Improving pharmacy revenue integrity.

PubMed

Carmody, Jennifer J; Townsend, Kyle; Schwartz, Kathy

2013-09-01

Billings Clinic learned the following important lessons in implementing a pharmacy revenue integrity initiative: Integrate pharmacy data as fully as possible. Audit and review pharmacy data regularly to validate the data and identify key areas where education can be provided to support accuracy and compliance. Use technology to bridge gaps between pharmacy data, such as gaps in billable units and billed units. Establish data governance workflows.

A Comparison of Product Realization Frameworks

DTIC Science & Technology

1993-10-01

software (integrated FrameMaker ). Also included are BOLD for on-line documentation delivery, printer/plotter support, and 18 network licensing support. AMPLE...are built with DSS. Documentation tools include an on-line information system (BOLD), text editing (Notepad), word processing (integrated FrameMaker ...within an application. FrameMaker is fully integrated with the Falcon Framework to provide consistent documentation capabilities within engineering

Online CTE in the Community College

ERIC Educational Resources Information Center

Garza Mitchell, Regina L.; Etshim, Rachal; Dietz, Brian T.

2016-01-01

This single-site case study explored how one community college integrated online education into CTE courses and programs. Through semi-structured interviews and document analysis, the study explores how one college integrated online education (fully online, hybrid, and web-enhanced) into areas typically considered "hands-on".…

Microfluidic integration of parallel solid-phase liquid chromatography.

PubMed

Huft, Jens; Haynes, Charles A; Hansen, Carl L

2013-03-05

We report the development of a fully integrated microfluidic chromatography system based on a recently developed column geometry that allows for robust packing of high-performance separation columns in poly(dimethylsiloxane) microfluidic devices having integrated valves made by multilayer soft lithography (MSL). The combination of parallel high-performance separation columns and on-chip plumbing was used to achieve a fully integrated system for on-chip chromatography, including all steps of automated sample loading, programmable gradient generation, separation, fluorescent detection, and sample recovery. We demonstrate this system in the separation of fluorescently labeled DNA and parallel purification of reverse transcription polymerase chain reaction (RT-PCR) amplified variable regions of mouse immunoglobulin genes using a strong anion exchange (AEX) resin. Parallel sample recovery in an immiscible oil stream offers the advantage of low sample dilution and high recovery rates. The ability to perform nucleic acid size selection and recovery on subnanogram samples of DNA holds promise for on-chip genomics applications including sequencing library preparation, cloning, and sample fractionation for diagnostics.

Fully integrated aerodynamic/dynamic optimization of helicopter rotor blades

NASA Technical Reports Server (NTRS)

Walsh, Joanne L.; Lamarsh, William J., II; Adelman, Howard M.

1992-01-01

This paper describes a fully integrated aerodynamic/dynamic optimization procedure for helicopter rotor blades. The procedure combines performance and dynamics analyses with a general purpose optimizer. The procedure minimizes a linear combination of power required (in hover, forward flight, and maneuver) and vibratory hub shear. The design variables include pretwist, taper initiation, taper ratio, root chord, blade stiffnesses, tuning masses, and tuning mass locations. Aerodynamic constraints consist of limits on power required in hover, forward flight and maneuver; airfoil section stall; drag divergence Mach number; minimum tip chord; and trim. Dynamic constraints are on frequencies, minimum autorotational inertia, and maximum blade weight. The procedure is demonstrated for two cases. In the first case the objective function involves power required (in hover, forward flight, and maneuver) and dynamics. The second case involves only hover power and dynamics. The designs from the integrated procedure are compared with designs from a sequential optimization approach in which the blade is first optimized for performance and then for dynamics. In both cases, the integrated approach is superior.

Fully integrated aerodynamic/dynamic optimization of helicopter rotor blades

NASA Technical Reports Server (NTRS)

Walsh, Joanne L.; Lamarsh, William J., II; Adelman, Howard M.

1992-01-01

A fully integrated aerodynamic/dynamic optimization procedure is described for helicopter rotor blades. The procedure combines performance and dynamic analyses with a general purpose optimizer. The procedure minimizes a linear combination of power required (in hover, forward flight, and maneuver) and vibratory hub shear. The design variables include pretwist, taper initiation, taper ratio, root chord, blade stiffnesses, tuning masses, and tuning mass locations. Aerodynamic constraints consist of limits on power required in hover, forward flight and maneuvers; airfoil section stall; drag divergence Mach number; minimum tip chord; and trim. Dynamic constraints are on frequencies, minimum autorotational inertia, and maximum blade weight. The procedure is demonstrated for two cases. In the first case, the objective function involves power required (in hover, forward flight and maneuver) and dynamics. The second case involves only hover power and dynamics. The designs from the integrated procedure are compared with designs from a sequential optimization approach in which the blade is first optimized for performance and then for dynamics. In both cases, the integrated approach is superior.

Regulation of multispanning membrane protein topology via post-translational annealing.

PubMed

Van Lehn, Reid C; Zhang, Bin; Miller, Thomas F

2015-09-26

The canonical mechanism for multispanning membrane protein topogenesis suggests that protein topology is established during cotranslational membrane integration. However, this mechanism is inconsistent with the behavior of EmrE, a dual-topology protein for which the mutation of positively charged loop residues, even close to the C-terminus, leads to dramatic shifts in its topology. We use coarse-grained simulations to investigate the Sec-facilitated membrane integration of EmrE and its mutants on realistic biological timescales. This work reveals a mechanism for regulating membrane-protein topogenesis, in which initially misintegrated configurations of the proteins undergo post-translational annealing to reach fully integrated multispanning topologies. The energetic barriers associated with this post-translational annealing process enforce kinetic pathways that dictate the topology of the fully integrated proteins. The proposed mechanism agrees well with the experimentally observed features of EmrE topogenesis and provides a range of experimentally testable predictions regarding the effect of translocon mutations on membrane protein topogenesis.

Extensive characterization of Tupaia belangeri neuropeptidome using an integrated mass spectrometric approach.

PubMed

Petruzziello, Filomena; Fouillen, Laetitia; Wadensten, Henrik; Kretz, Robert; Andren, Per E; Rainer, Gregor; Zhang, Xiaozhe

2012-02-03

Neuropeptidomics is used to characterize endogenous peptides in the brain of tree shrews (Tupaia belangeri). Tree shrews are small animals similar to rodents in size but close relatives of primates, and are excellent models for brain research. Currently, tree shrews have no complete proteome information available on which direct database search can be allowed for neuropeptide identification. To increase the capability in the identification of neuropeptides in tree shrews, we developed an integrated mass spectrometry (MS)-based approach that combines methods including data-dependent, directed, and targeted liquid chromatography (LC)-Fourier transform (FT)-tandem MS (MS/MS) analysis, database construction, de novo sequencing, precursor protein search, and homology analysis. Using this integrated approach, we identified 107 endogenous peptides that have sequences identical or similar to those from other mammalian species. High accuracy MS and tandem MS information, with BLAST analysis and chromatographic characteristics were used to confirm the sequences of all the identified peptides. Interestingly, further sequence homology analysis demonstrated that tree shrew peptides have a significantly higher degree of homology to equivalent sequences in humans than those in mice or rats, consistent with the close phylogenetic relationship between tree shrews and primates. Our results provide the first extensive characterization of the peptidome in tree shrews, which now permits characterization of their function in nervous and endocrine system. As the approach developed fully used the conservative properties of neuropeptides in evolution and the advantage of high accuracy MS, it can be portable for identification of neuropeptides in other species for which the fully sequenced genomes or proteomes are not available.

The EBM-DPSER Conceptual Model: Integrating Ecosystem Services into the DPSIR Framework

PubMed Central

Kelble, Christopher R.; Loomis, Dave K.; Lovelace, Susan; Nuttle, William K.; Ortner, Peter B.; Fletcher, Pamela; Cook, Geoffrey S.; Lorenz, Jerry J.; Boyer, Joseph N.

2013-01-01

There is a pressing need to integrate biophysical and human dimensions science to better inform holistic ecosystem management supporting the transition from single species or single-sector management to multi-sector ecosystem-based management. Ecosystem-based management should focus upon ecosystem services, since they reflect societal goals, values, desires, and benefits. The inclusion of ecosystem services into holistic management strategies improves management by better capturing the diversity of positive and negative human-natural interactions and making explicit the benefits to society. To facilitate this inclusion, we propose a conceptual model that merges the broadly applied Driver, Pressure, State, Impact, and Response (DPSIR) conceptual model with ecosystem services yielding a Driver, Pressure, State, Ecosystem service, and Response (EBM-DPSER) conceptual model. The impact module in traditional DPSIR models focuses attention upon negative anthropomorphic impacts on the ecosystem; by replacing impacts with ecosystem services the EBM-DPSER model incorporates not only negative, but also positive changes in the ecosystem. Responses occur as a result of changes in ecosystem services and include inter alia management actions directed at proactively altering human population or individual behavior and infrastructure to meet societal goals. The EBM-DPSER conceptual model was applied to the Florida Keys and Dry Tortugas marine ecosystem as a case study to illustrate how it can inform management decisions. This case study captures our system-level understanding and results in a more holistic representation of ecosystem and human society interactions, thus improving our ability to identify trade-offs. The EBM-DPSER model should be a useful operational tool for implementing EBM, in that it fully integrates our knowledge of all ecosystem components while focusing management attention upon those aspects of the ecosystem most important to human society and does so within a framework already familiar to resource managers. PMID:23951002

The EBM-DPSER conceptual model: integrating ecosystem services into the DPSIR framework.

PubMed

Kelble, Christopher R; Loomis, Dave K; Lovelace, Susan; Nuttle, William K; Ortner, Peter B; Fletcher, Pamela; Cook, Geoffrey S; Lorenz, Jerry J; Boyer, Joseph N

2013-01-01

There is a pressing need to integrate biophysical and human dimensions science to better inform holistic ecosystem management supporting the transition from single species or single-sector management to multi-sector ecosystem-based management. Ecosystem-based management should focus upon ecosystem services, since they reflect societal goals, values, desires, and benefits. The inclusion of ecosystem services into holistic management strategies improves management by better capturing the diversity of positive and negative human-natural interactions and making explicit the benefits to society. To facilitate this inclusion, we propose a conceptual model that merges the broadly applied Driver, Pressure, State, Impact, and Response (DPSIR) conceptual model with ecosystem services yielding a Driver, Pressure, State, Ecosystem service, and Response (EBM-DPSER) conceptual model. The impact module in traditional DPSIR models focuses attention upon negative anthropomorphic impacts on the ecosystem; by replacing impacts with ecosystem services the EBM-DPSER model incorporates not only negative, but also positive changes in the ecosystem. Responses occur as a result of changes in ecosystem services and include inter alia management actions directed at proactively altering human population or individual behavior and infrastructure to meet societal goals. The EBM-DPSER conceptual model was applied to the Florida Keys and Dry Tortugas marine ecosystem as a case study to illustrate how it can inform management decisions. This case study captures our system-level understanding and results in a more holistic representation of ecosystem and human society interactions, thus improving our ability to identify trade-offs. The EBM-DPSER model should be a useful operational tool for implementing EBM, in that it fully integrates our knowledge of all ecosystem components while focusing management attention upon those aspects of the ecosystem most important to human society and does so within a framework already familiar to resource managers.

Traffic and Driving Simulator Based on Architecture of Interactive Motion.

PubMed

Paz, Alexander; Veeramisti, Naveen; Khaddar, Romesh; de la Fuente-Mella, Hanns; Modorcea, Luiza

2015-01-01

This study proposes an architecture for an interactive motion-based traffic simulation environment. In order to enhance modeling realism involving actual human beings, the proposed architecture integrates multiple types of simulation, including: (i) motion-based driving simulation, (ii) pedestrian simulation, (iii) motorcycling and bicycling simulation, and (iv) traffic flow simulation. The architecture has been designed to enable the simulation of the entire network; as a result, the actual driver, pedestrian, and bike rider can navigate anywhere in the system. In addition, the background traffic interacts with the actual human beings. This is accomplished by using a hybrid mesomicroscopic traffic flow simulation modeling approach. The mesoscopic traffic flow simulation model loads the results of a user equilibrium traffic assignment solution and propagates the corresponding traffic through the entire system. The microscopic traffic flow simulation model provides background traffic around the vicinities where actual human beings are navigating the system. The two traffic flow simulation models interact continuously to update system conditions based on the interactions between actual humans and the fully simulated entities. Implementation efforts are currently in progress and some preliminary tests of individual components have been conducted. The implementation of the proposed architecture faces significant challenges ranging from multiplatform and multilanguage integration to multievent communication and coordination.

Traffic and Driving Simulator Based on Architecture of Interactive Motion

PubMed Central

Paz, Alexander; Veeramisti, Naveen; Khaddar, Romesh; de la Fuente-Mella, Hanns; Modorcea, Luiza

2015-01-01

This study proposes an architecture for an interactive motion-based traffic simulation environment. In order to enhance modeling realism involving actual human beings, the proposed architecture integrates multiple types of simulation, including: (i) motion-based driving simulation, (ii) pedestrian simulation, (iii) motorcycling and bicycling simulation, and (iv) traffic flow simulation. The architecture has been designed to enable the simulation of the entire network; as a result, the actual driver, pedestrian, and bike rider can navigate anywhere in the system. In addition, the background traffic interacts with the actual human beings. This is accomplished by using a hybrid mesomicroscopic traffic flow simulation modeling approach. The mesoscopic traffic flow simulation model loads the results of a user equilibrium traffic assignment solution and propagates the corresponding traffic through the entire system. The microscopic traffic flow simulation model provides background traffic around the vicinities where actual human beings are navigating the system. The two traffic flow simulation models interact continuously to update system conditions based on the interactions between actual humans and the fully simulated entities. Implementation efforts are currently in progress and some preliminary tests of individual components have been conducted. The implementation of the proposed architecture faces significant challenges ranging from multiplatform and multilanguage integration to multievent communication and coordination. PMID:26491711

Inner and outer coronary vessel wall segmentation from CCTA using an active contour model with machine learning-based 3D voxel context-aware image force

NASA Astrophysics Data System (ADS)

Sivalingam, Udhayaraj; Wels, Michael; Rempfler, Markus; Grosskopf, Stefan; Suehling, Michael; Menze, Bjoern H.

2016-03-01

In this paper, we present a fully automated approach to coronary vessel segmentation, which involves calcification or soft plaque delineation in addition to accurate lumen delineation, from 3D Cardiac Computed Tomography Angiography data. Adequately virtualizing the coronary lumen plays a crucial role for simulating blood ow by means of fluid dynamics while additionally identifying the outer vessel wall in the case of arteriosclerosis is a prerequisite for further plaque compartment analysis. Our method is a hybrid approach complementing Active Contour Model-based segmentation with an external image force that relies on a Random Forest Regression model generated off-line. The regression model provides a strong estimate of the distance to the true vessel surface for every surface candidate point taking into account 3D wavelet-encoded contextual image features, which are aligned with the current surface hypothesis. The associated external image force is integrated in the objective function of the active contour model, such that the overall segmentation approach benefits from the advantages associated with snakes and from the ones associated with machine learning-based regression alike. This yields an integrated approach achieving competitive results on a publicly available benchmark data collection (Rotterdam segmentation challenge).

The development and validation of a numerical integration method for non-linear viscoelastic modeling

PubMed Central

Ramo, Nicole L.; Puttlitz, Christian M.

2018-01-01

Compelling evidence that many biological soft tissues display both strain- and time-dependent behavior has led to the development of fully non-linear viscoelastic modeling techniques to represent the tissue’s mechanical response under dynamic conditions. Since the current stress state of a viscoelastic material is dependent on all previous loading events, numerical analyses are complicated by the requirement of computing and storing the stress at each step throughout the load history. This requirement quickly becomes computationally expensive, and in some cases intractable, for finite element models. Therefore, we have developed a strain-dependent numerical integration approach for capturing non-linear viscoelasticity that enables calculation of the current stress from a strain-dependent history state variable stored from the preceding time step only, which improves both fitting efficiency and computational tractability. This methodology was validated based on its ability to recover non-linear viscoelastic coefficients from simulated stress-relaxation (six strain levels) and dynamic cyclic (three frequencies) experimental stress-strain data. The model successfully fit each data set with average errors in recovered coefficients of 0.3% for stress-relaxation fits and 0.1% for cyclic. The results support the use of the presented methodology to develop linear or non-linear viscoelastic models from stress-relaxation or cyclic experimental data of biological soft tissues. PMID:29293558

RRegrs: an R package for computer-aided model selection with multiple regression models.

PubMed

Tsiliki, Georgia; Munteanu, Cristian R; Seoane, Jose A; Fernandez-Lozano, Carlos; Sarimveis, Haralambos; Willighagen, Egon L

2015-01-01

Predictive regression models can be created with many different modelling approaches. Choices need to be made for data set splitting, cross-validation methods, specific regression parameters and best model criteria, as they all affect the accuracy and efficiency of the produced predictive models, and therefore, raising model reproducibility and comparison issues. Cheminformatics and bioinformatics are extensively using predictive modelling and exhibit a need for standardization of these methodologies in order to assist model selection and speed up the process of predictive model development. A tool accessible to all users, irrespectively of their statistical knowledge, would be valuable if it tests several simple and complex regression models and validation schemes, produce unified reports, and offer the option to be integrated into more extensive studies. Additionally, such methodology should be implemented as a free programming package, in order to be continuously adapted and redistributed by others. We propose an integrated framework for creating multiple regression models, called RRegrs. The tool offers the option of ten simple and complex regression methods combined with repeated 10-fold and leave-one-out cross-validation. Methods include Multiple Linear regression, Generalized Linear Model with Stepwise Feature Selection, Partial Least Squares regression, Lasso regression, and Support Vector Machines Recursive Feature Elimination. The new framework is an automated fully validated procedure which produces standardized reports to quickly oversee the impact of choices in modelling algorithms and assess the model and cross-validation results. The methodology was implemented as an open source R package, available at https://www.github.com/enanomapper/RRegrs, by reusing and extending on the caret package. The universality of the new methodology is demonstrated using five standard data sets from different scientific fields. Its efficiency in cheminformatics and QSAR modelling is shown with three use cases: proteomics data for surface-modified gold nanoparticles, nano-metal oxides descriptor data, and molecular descriptors for acute aquatic toxicity data. The results show that for all data sets RRegrs reports models with equal or better performance for both training and test sets than those reported in the original publications. Its good performance as well as its adaptability in terms of parameter optimization could make RRegrs a popular framework to assist the initial exploration of predictive models, and with that, the design of more comprehensive in silico screening applications.Graphical abstractRRegrs is a computer-aided model selection framework for R multiple regression models; this is a fully validated procedure with application to QSAR modelling.

A global dataset of sub-daily rainfall indices

NASA Astrophysics Data System (ADS)

Fowler, H. J.; Lewis, E.; Blenkinsop, S.; Guerreiro, S.; Li, X.; Barbero, R.; Chan, S.; Lenderink, G.; Westra, S.

2017-12-01

It is still uncertain how hydrological extremes will change with global warming as we do not fully understand the processes that cause extreme precipitation under current climate variability. The INTENSE project is using a novel and fully-integrated data-modelling approach to provide a step-change in our understanding of the nature and drivers of global precipitation extremes and change on societally relevant timescales, leading to improved high-resolution climate model representation of extreme rainfall processes. The INTENSE project is in conjunction with the World Climate Research Programme (WCRP)'s Grand Challenge on 'Understanding and Predicting Weather and Climate Extremes' and the Global Water and Energy Exchanges Project (GEWEX) Science questions. A new global sub-daily precipitation dataset has been constructed (data collection is ongoing). Metadata for each station has been calculated, detailing record lengths, missing data, station locations. A set of global hydroclimatic indices have been produced based upon stakeholder recommendations including indices that describe maximum rainfall totals and timing, the intensity, duration and frequency of storms, frequency of storms above specific thresholds and information about the diurnal cycle. This will provide a unique global data resource on sub-daily precipitation whose derived indices will be freely available to the wider scientific community.

Supporting Academic Integrity in a Fully-Online Degree Completion Program through the Use of Synchronous Video Conferences

ERIC Educational Resources Information Center

Wagner, Erica; Enders, Jeanne; Pirie, Melissa Shaquid; Thomas, Domanic

2016-01-01

Since 2012, we have used synchronous, web-based video conferences in our fully-online degree completion program. Students are required to participate in four live video conferences with their professor and a small group of peers in all upper division online courses as a minimum requirement for passing the class. While these synchronous video…

Integrating Digital Technology in an Intensive, Fully Online College Course for Japanese Beginning Learners: A Standards-Based, Performance-Driven Approach

ERIC Educational Resources Information Center

Sato, Eriko; Chen, Julian Cheng Chiang; Jourdain, Sarah

2017-01-01

The development of distance learning courses for less commonly taught languages (LCTLs) often meets with instructional challenges, especially for Asian LCTLs with their distinct non-Roman characters and structures. This study documents the implementation of a fully online, elementary Japanese course at Stony Brook University. The curriculum was…

Four decades of modeling methane cycling in terrestrial ecosystems: Where we are heading?

NASA Astrophysics Data System (ADS)

Xu, X.; Yuan, F.; Hanson, P. J.; Wullschleger, S. D.; Thornton, P. E.; Tian, H.; Riley, W. J.; Song, X.; Graham, D. E.; Song, C.

2015-12-01

A modeling approach to methane (CH4) is widely used to quantify the budget, investigate spatial and temporal variabilities, and understand the mechanistic processes and environmental controls on CH4 fluxes across spatial and temporal scales. Moreover, CH4 models are an important tool for integrating CH4 data from multiple sources, such as laboratory-based incubation and molecular analysis, field observational experiments, remote sensing, and aircraft-based measurements across a variety of terrestrial ecosystems. We reviewed 39 terrestrial CH4 models to characterize their strengths and weaknesses and to design a roadmap for future model improvement and application. We found that: (1) the focus of CH4 models have been shifted from theoretical to site- to regional-level application over the past four decades, expressed as dramatic increases in CH4 model development on regional budget quantification; (2) large discrepancies exist among models in terms of representing CH4 processes and their environmental controls; (3) significant data-model and model-model mismatches are partially attributed to different representations of wetland characterization and inundation dynamics. Three efforts should be paid special attention for future improvements and applications of fully mechanistic CH4 models: (1) CH4 models should be improved to represent the mechanisms underlying land-atmosphere CH4 exchange, with emphasis on improving and validating individual CH4 processes over depth and horizontal space; (2) models should be developed that are capable of simulating CH4 fluxes across space and time (particularly hot moments and hot spots); (3) efforts should be invested to develop model benchmarking frameworks that can easily be used for model improvement, evaluation, and integration with data from molecular to global scales. A newly developed microbial functional group-based CH4 model (CLM-Microbe) was further used to demonstrate the features of mechanistic representation and integration with multiple source of observational datasets.

Advancing Physically-Based Flow Simulations of Alluvial Systems Through Atmospheric Noble Gases and the Novel 37Ar Tracer Method

NASA Astrophysics Data System (ADS)

Schilling, Oliver S.; Gerber, Christoph; Partington, Daniel J.; Purtschert, Roland; Brennwald, Matthias S.; Kipfer, Rolf; Hunkeler, Daniel; Brunner, Philip

2017-12-01

To provide a sound understanding of the sources, pathways, and residence times of groundwater water in alluvial river-aquifer systems, a combined multitracer and modeling experiment was carried out in an important alluvial drinking water wellfield in Switzerland. 222Rn, 3H/3He, atmospheric noble gases, and the novel 37Ar-method were used to quantify residence times and mixing ratios of water from different sources. With a half-life of 35.1 days, 37Ar allowed to successfully close a critical observational time gap between 222Rn and 3H/3He for residence times of weeks to months. Covering the entire range of residence times of groundwater in alluvial systems revealed that, to quantify the fractions of water from different sources in such systems, atmospheric noble gases and helium isotopes are tracers suited for end-member mixing analysis. A comparison between the tracer-based mixing ratios and mixing ratios simulated with a fully-integrated, physically-based flow model showed that models, which are only calibrated against hydraulic heads, cannot reliably reproduce mixing ratios or residence times of alluvial river-aquifer systems. However, the tracer-based mixing ratios allowed the identification of an appropriate flow model parametrization. Consequently, for alluvial systems, we recommend the combination of multitracer studies that cover all relevant residence times with fully-coupled, physically-based flow modeling to better characterize the complex interactions of river-aquifer systems.

Traveling wave solutions of the nonlinear Schrödinger equation

NASA Astrophysics Data System (ADS)

Akbari-Moghanjoughi, M.

2017-10-01

In this paper, we investigate the traveling soliton and the periodic wave solutions of the nonlinear Schrödinger equation (NLSE) with generalized nonlinear functionality. We also explore the underlying close connection between the well-known KdV equation and the NLSE. It is remarked that both one-dimensional KdV and NLSE models share the same pseudoenergy spectrum. We also derive the traveling wave solutions for two cases of weakly nonlinear mathematical models, namely, the Helmholtz and the Duffing oscillators' potentials. It is found that these models only allow gray-type NLSE solitary propagations. It is also found that the pseudofrequency ratio for the Helmholtz potential between the nonlinear periodic carrier and the modulated sinusoidal waves is always in the range 0.5 ≤ Ω/ω ≤ 0.537285 regardless of the potential parameter values. The values of Ω/ω = {0.5, 0.537285} correspond to the cnoidal waves modulus of m = {0, 1} for soliton and sinusoidal limits and m = 0.5, respectively. Moreover, the current NLSE model is extended to fully NLSE (FNLSE) situation for Sagdeev oscillator pseudopotential which can be derived using a closed set of hydrodynamic fluid equations with a fully integrable Hamiltonian system. The generalized quasi-three-dimensional traveling wave solution is also derived. The current simple hydrodynamic plasma model may also be generalized to two dimensions and other complex situations including different charged species and cases with magnetic or gravitational field effects.

Open Software Tools Applied to Jordan's National Multi-Agent Water Management Model

NASA Astrophysics Data System (ADS)

Knox, Stephen; Meier, Philipp; Harou, Julien; Yoon, Jim; Selby, Philip; Lachaut, Thibaut; Klassert, Christian; Avisse, Nicolas; Khadem, Majed; Tilmant, Amaury; Gorelick, Steven

2016-04-01

Jordan is the fourth most water scarce country in the world, where demand exceeds supply in a politically and demographically unstable context. The Jordan Water Project (JWP) aims to perform policy evaluation by modelling the hydrology, economics, and governance of Jordan's water resource system. The multidisciplinary nature of the project requires a modelling software system capable of integrating submodels from multiple disciplines into a single decision making process and communicating results to stakeholders. This requires a tool for building an integrated model and a system where diverse data sets can be managed and visualised. The integrated Jordan model is built using Pynsim, an open-source multi-agent simulation framework implemented in Python. Pynsim operates on network structures of nodes and links and supports institutional hierarchies, where an institution represents a grouping of nodes, links or other institutions. At each time step, code within each node, link and institution can executed independently, allowing for their fully autonomous behaviour. Additionally, engines (sub-models) perform actions over the entire network or on a subset of the network, such as taking a decision on a set of nodes. Pynsim is modular in design, allowing distinct modules to be modified easily without affecting others. Data management and visualisation is performed using Hydra (www.hydraplatform.org), an open software platform allowing users to manage network structure and data. The Hydra data manager connects to Pynsim, providing necessary input parameters for the integrated model. By providing a high-level portal to the model, Hydra removes a barrier between the users of the model (researchers, stakeholders, planners etc) and the model itself, allowing them to manage data, run the model and visualise results all through a single user interface. Pynsim's ability to represent institutional hierarchies, inter-network communication and the separation of node, link and institutional logic from higher level processes (engine) suit JWP's requirements. The use of Hydra Platform and Pynsim helps make complex customised models such as the JWP model easier to run and manage with international groups of researchers.

Incorporation of an Energy Equation into a Pulsed Inductive Thruster Performance Model

NASA Technical Reports Server (NTRS)

Polzin, Kurt A.; Reneau, Jarred P.; Sankaran, Kameshwaran

2011-01-01

A model for pulsed inductive plasma acceleration containing an energy equation to account for the various sources and sinks in such devices is presented. The model consists of a set of circuit equations coupled to an equation of motion and energy equation for the plasma. The latter two equations are obtained for the plasma current sheet by treating it as a one-element finite volume, integrating the equations over that volume, and then matching known terms or quantities already calculated in the model to the resulting current sheet-averaged terms in the equations. Calculations showing the time-evolution of the various sources and sinks in the system are presented to demonstrate the efficacy of the model, with two separate resistivity models employed to show an example of how the plasma transport properties can affect the calculation. While neither resistivity model is fully accurate, the demonstration shows that it is possible within this modeling framework to time-accurately update various plasma parameters.

Modeling the detailed kinetics of mitochondrial cytochrome c oxidase: Catalytic mechanism and nitric oxide inhibition

PubMed Central

Pannala, Venkat R.; Camara, Amadou K. S.

2016-01-01

Cytochrome c oxidase (CcO) catalyzes the exothermic reduction of O2 to H2O by using electrons from cytochrome c, and hence plays a crucial role in ATP production. Although details on the enzyme structure and redox centers involved in O2 reduction have been known, there still remains a considerable ambiguity on its mechanism of action, e.g., the number of sequential electrons donated to O2 in each catalytic step, the sites of protonation and proton pumping, and nitric oxide (NO) inhibition mechanism. In this work, we developed a thermodynamically constrained mechanistic mathematical model for the catalytic action of CcO based on available kinetic data. The model considers a minimal number of redox centers on CcO and couples electron transfer and proton pumping driven by proton motive force (PMF), and accounts for the inhibitory effects of NO on the reaction kinetics. The model is able to fit well all the available kinetic data under diverse experimental conditions with a physiologically realistic unique parameter set. The model predictions show that: 1) the apparent Km of O2 varies considerably and increases from fully reduced to fully oxidized cytochrome c depending on pH and the energy state of mitochondria, and 2) the intermediate enzyme states depend on pH and cytochrome c redox fraction and play a central role in coupling mitochondrial respiration to PMF. The developed CcO model can easily be integrated into existing mitochondrial bioenergetics models to understand the role of the enzyme in controlling oxidative phosphorylation in normal and disease conditions. PMID:27633738