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Sample records for functionally rigid bistable

  1. Large-strain, rigid-to-rigid deformation of bistable electroactive polymers

    NASA Astrophysics Data System (ADS)

    Yu, Zhibin; Yuan, Wei; Brochu, Paul; Chen, Bin; Liu, Zhitian; Pei, Qibing

    2009-11-01

    Thermoplastic poly(tert-butyl acrylate) (PTBA) is reported as an electroactive polymer that is rigid at ambient conditions and turns into a dielectric elastomer above a transition temperature. In the rubbery state, a PTBA thin film can be electrically actuated to strains up to 335% in area expansion. The calculated actuation pressure is 3.2 MPa. The actuation is made bistable by cooling to below glass transition temperature. The PTBA represents the bistable electroactive polymer (BSEP) that can be actuated to various largely strained, rigid shapes. The application of the BSEP for refreshable Braille display, an active tactile display, is also demonstrated.

  2. Modeling rigid magnetically rotated microswimmers: Rotation axes, bistability, and controllability

    NASA Astrophysics Data System (ADS)

    Meshkati, Farshad; Fu, Henry Chien

    2014-12-01

    Magnetically actuated microswimmers have recently attracted attention due to many possible biomedical applications. In this study we investigate the dynamics of rigid magnetically rotated microswimmers with permanent magnetic dipoles. Our approach uses a boundary element method to calculate a mobility matrix, accurate for arbitrary geometries, which is then used to identify the steady periodically rotating orbits in a co-rotating body-fixed frame. We evaluate the stability of each of these orbits. We map the magnetoviscous behavior as a function of dimensionless Mason number and as a function of the angle that the magnetic field makes with its rotation axis. We describe the wobbling motion of these swimmers by investigating how the rotation axis changes as a function of experimental parameters. We show that for a given magnetic field strength and rotation frequency, swimmers can have more than one stable periodic orbit with different rotation axes. Finally, we demonstrate that one can improve the controllability of these types of microswimmers by adjusting the relative angle between the magnetic field and its axis of rotation.

  3. Bistable electroactive polymers (BSEP): large-strain actuation of rigid polymers

    NASA Astrophysics Data System (ADS)

    Yu, Zhibin; Niu, Xiaofan; Brochu, Paul; Yuan, Wei; Li, Huafeng; Chen, Bin; Pei, Qibing

    2010-04-01

    Reversible, large-strain, bistable actuation has been a lasting puzzle in the pursuit of smart materials and structures. Conducting polymers are bistable, but the achievable strain is small. Large deformations have been achieved in dielectric elastomers at the expense of mechanical strength. The gel or gel-like soft polymers generally have elastic moduli around or less than 10 MPa. The deformed polymer relaxes to its original shape once the applied electric field is removed. We report new, bistable electroactive polymers (BSEP) that are capable of electrically actuated strains as high as 335% area strain. The BSEP could be useful for constructing rigid structures. The structures can support high mechanical loads, and be actuated to large-strain deformations. We will present one unique application of the BSEP for Braille displays that can be quickly refreshed and maintain the displayed contents without a bias voltage.

  4. Bistable electroactive polymer with sharp rigid-to-rubbery phase transition

    NASA Astrophysics Data System (ADS)

    Qiu, Yu; Ren, Zhi; Hu, Wei; Liu, Chao; Pei, Qibing

    2016-04-01

    Bistable electroactive polymers (BSEP) usually exhibit glass transition that spans a rather broad temperature range and are normally actuated above 70 °C. High actuation temperature limits the BSEP for wearable and personal assistive applications. A phase-changing polymer is synthesized and employed as BSEP having a narrow rigid-to-rubbery transition temperature range. Shape memory effect with both fixation and recovery rate close to 100% was observed. Diaphragm actuators of the BSEP can be electrically actuated at 50 °C up to 70% strain, and the deformed shape was fixed after cooling the BSEP below the transition temperature. The rigid-to-rigid actuation can be repeated for at least 10,000 cycles.

  5. Unbiased rigid registration using transfer functions

    NASA Astrophysics Data System (ADS)

    Hahn, Dieter A.; Hornegger, Joachim; Bautz, Werner; Kuwert, Torsten; Roemer, Wolfgang

    2005-04-01

    The evaluation of tumor growth as regression under therapy is an important clinical issue. Rigid registration of sequentially acquired 3D-images has proven its value for this purpose. Existing approaches to rigid image registration use the whole volume for the estimation of the rigid transform. Non-rigid soft tissue deformation, however, will imply a bias to the registration result, because local deformations cannot be modeled by rigid transforms. Anatomical substructures, like bones or teeth, are not affected by these deformations, but follow a rigid transform. This important observation is incorporated in the proposed registration algorithm. The selection of anatomical substructure is done by manual interaction of medical experts adjusting the transfer function of the volume rendering software. The parameters of the transfer function are used to identify the voxels that are considered for registration. A rigid transform is estimated by a quaternion gradient descent algorithm based on the intensity values of the specified tissue classes. Commonly used voxel intensity measures are adjusted to the modified registration algorithm. The contribution describes the mathematical framework of the proposed registration method and its implementation in a commercial software package. The experimental evaluation includes the discussion of different similarity measures, the comparison of the proposed method to established rigid registration techniques and the evaluation of the efficiency of the new method. We conclude with the discussion of potential medical applications of the proposed registration algorithm.

  6. Fractionation of parietal function in bistable perception probed with concurrent TMS-EEG.

    PubMed

    Schauer, Georg; Chang, Acer; Schwartzman, David; Rae, Charlotte L; Iriye, Heather; Seth, Anil K; Kanai, Ryota

    2016-01-01

    When visual input has conflicting interpretations, conscious perception can alternate spontaneously between these possible interpretations. This is called bistable perception. Previous neuroimaging studies have indicated the involvement of two right parietal areas in resolving perceptual ambiguity (ant-SPLr and post-SPLr). Transcranial magnetic stimulation (TMS) studies that selectively interfered with the normal function of these regions suggest that they play opposing roles in this type of perceptual switch. In the present study, we investigated this fractionation of parietal function by use of combined TMS with electroencephalography (EEG). Specifically, while participants viewed either a bistable stimulus, a replay stimulus, or resting-state fixation, we applied single pulse TMS to either location independently while simultaneously recording EEG. Combined with participant's individual structural magnetic resonance imaging (MRI) scans, this dataset allows for complex analyses of the effect of TMS on neural time series data, which may further elucidate the causal role of the parietal cortex in ambiguous perception. PMID:27529410

  7. Parietal theta burst TMS: Functional fractionation observed during bistable perception not evident in attention tasks.

    PubMed

    Schauer, Georg; Kanai, Ryota; Brascamp, Jan W

    2016-02-01

    When visual input is ambiguous, perception spontaneously alternates between interpretations: bistable perception. Studies have identified two distinct sites near the right intraparietal sulcus where inhibitory transcranial magnetic stimulation (TMS) affects the frequency of occurrence of these alternations, but strikingly with opposite directions of effect for the two sites. Lesion and TMS studies on spatial and sustained attention have also indicated a parcellation of right parietal cortex, into areas serving distinct attentional functions. We used the exact TMS procedure previously employed to affect bistable perception, yet measured its effect on spatial and sustained attention tasks. Although there was a trend for TMS to affect performance, trends were consistently similar for both parietal sites, with no indication of opposite effects. We interpret this as signifying that the previously observed parietal fractionation of function regarding the perception of ambiguous stimuli is not due to TMS-induced modification of spatial or sustained attention.

  8. Fractionation of parietal function in bistable perception probed with concurrent TMS-EEG

    PubMed Central

    Schauer, Georg; Chang, Acer; Schwartzman, David; Rae, Charlotte L.; Iriye, Heather; Seth, Anil K.; Kanai, Ryota

    2016-01-01

    When visual input has conflicting interpretations, conscious perception can alternate spontaneously between these possible interpretations. This is called bistable perception. Previous neuroimaging studies have indicated the involvement of two right parietal areas in resolving perceptual ambiguity (ant-SPLr and post-SPLr). Transcranial magnetic stimulation (TMS) studies that selectively interfered with the normal function of these regions suggest that they play opposing roles in this type of perceptual switch. In the present study, we investigated this fractionation of parietal function by use of combined TMS with electroencephalography (EEG). Specifically, while participants viewed either a bistable stimulus, a replay stimulus, or resting-state fixation, we applied single pulse TMS to either location independently while simultaneously recording EEG. Combined with participant’s individual structural magnetic resonance imaging (MRI) scans, this dataset allows for complex analyses of the effect of TMS on neural time series data, which may further elucidate the causal role of the parietal cortex in ambiguous perception. PMID:27529410

  9. Master equation for a bistable chemical system with perturbed particle velocity distribution function.

    PubMed

    Dziekan, P; Lemarchand, A; Nowakowski, B

    2012-02-01

    We present a modified master equation for a homogeneous gaseous reactive system which includes nonequilibrium corrections due to the reaction-induced perturbation of the particle velocity distribution function. For the Schlögl model, the modified stochastic approach predicts nonequilibrium-induced transitions between different dynamical regimes, including the transformation of a monostable system into a bistable one, and vice versa. These predictions are confirmed by the comparison with microscopic simulations using the direct simulation Monte Carlo method. Compared to microscopic simulations of the particle dynamics, the modified master equation approach proves to be much more efficient.

  10. Geometric and electrostatic modeling using molecular rigidity functions

    DOE PAGES

    Mu, Lin; Xia, Kelin; Wei, Guowei

    2017-03-01

    Geometric and electrostatic modeling is an essential component in computational biophysics and molecular biology. Commonly used geometric representations admit geometric singularities such as cusps, tips and self-intersecting facets that lead to computational instabilities in the molecular modeling. Our present work explores the use of flexibility and rigidity index (FRI), which has a proved superiority in protein B-factor prediction, for biomolecular geometric representation and associated electrostatic analysis. FRI rigidity surfaces are free of geometric singularities. We propose a rigidity based Poisson–Boltzmann equation for biomolecular electrostatic analysis. These approaches to surface and electrostatic modeling are validated by a set of 21 proteins.more » Our results are compared with those of established methods. Finally, being smooth and analytically differentiable, FRI rigidity functions offer excellent curvature analysis, which characterizes concave and convex regions on protein surfaces. Polarized curvatures constructed by using the product of minimum curvature and electrostatic potential is shown to predict potential protein–ligand binding sites.« less

  11. Functional integrity of flexible n-channel metal–oxide–semiconductor field-effect transistors on a reversibly bistable platform

    SciTech Connect

    Alfaraj, Nasir; Hussain, Aftab M.; Torres Sevilla, Galo A.; Ghoneim, Mohamed T.; Rojas, Jhonathan P.; Hussain, Muhammad M.; Aljedaani, Abdulrahman B.

    2015-10-26

    Flexibility can bring a new dimension to state-of-the-art electronics, such as rollable displays and integrated circuit systems being transformed into more powerful resources. Flexible electronics are typically hosted on polymeric substrates. Such substrates can be bent and rolled up, but cannot be independently fixed at the rigid perpendicular position necessary to realize rollable display-integrated gadgets and electronics. A reversibly bistable material can assume two stable states in a reversible way: flexibly rolled state and independently unbent state. Such materials are used in cycling and biking safety wristbands and a variety of ankle bracelets for orthopedic healthcare. They are often wrapped around an object with high impulsive force loading. Here, we study the effects of cumulative impulsive force loading on thinned (25 μm) flexible silicon-based n-channel metal–oxide–semiconductor field-effect transistor devices housed on a reversibly bistable flexible platform. We found that the transistors have maintained their high performance level up to an accumulated 180 kN of impact force loading. The gate dielectric layers have maintained their reliability, which is evidenced by the low leakage current densities. Also, we observed low variation in the effective electron mobility values, which manifests that the device channels have maintained their carrier transport properties.

  12. Functional integrity of flexible n-channel metal-oxide-semiconductor field-effect transistors on a reversibly bistable platform

    NASA Astrophysics Data System (ADS)

    Alfaraj, Nasir; Hussain, Aftab M.; Torres Sevilla, Galo A.; Ghoneim, Mohamed T.; Rojas, Jhonathan P.; Aljedaani, Abdulrahman B.; Hussain, Muhammad M.

    2015-10-01

    Flexibility can bring a new dimension to state-of-the-art electronics, such as rollable displays and integrated circuit systems being transformed into more powerful resources. Flexible electronics are typically hosted on polymeric substrates. Such substrates can be bent and rolled up, but cannot be independently fixed at the rigid perpendicular position necessary to realize rollable display-integrated gadgets and electronics. A reversibly bistable material can assume two stable states in a reversible way: flexibly rolled state and independently unbent state. Such materials are used in cycling and biking safety wristbands and a variety of ankle bracelets for orthopedic healthcare. They are often wrapped around an object with high impulsive force loading. Here, we study the effects of cumulative impulsive force loading on thinned (25 μm) flexible silicon-based n-channel metal-oxide-semiconductor field-effect transistor devices housed on a reversibly bistable flexible platform. We found that the transistors have maintained their high performance level up to an accumulated 180 kN of impact force loading. The gate dielectric layers have maintained their reliability, which is evidenced by the low leakage current densities. Also, we observed low variation in the effective electron mobility values, which manifests that the device channels have maintained their carrier transport properties.

  13. Function principle of a relaxation oscillator based on a bistable quantum Hall device

    NASA Astrophysics Data System (ADS)

    Nachtwei, G.; Kalugin, N. G.; Saǧol, B. E.; Stellmach, Ch.; Hein, G.

    2003-03-01

    We present a simple relaxation oscillator based on a quantum Hall device with Corbino geometry near the breakdown of the quantum Hall effect. In the hysteresis region of the breakdown, the quantum Hall device exhibits bistable behavior. If a resistance is connected in series and a capacitor in parallel to the quantum Hall device, the bistable switching leads to subsequent charging and discharging of the capacitor, detectable as relaxation oscillations. We explain the observed oscillations by solving Kirchhoff's equations and obtain a good quantitative description of the experiment. From this, we deduce some dynamical parameters of the Corbino device and discuss the performance limits of the oscillator.

  14. Generic Bistability in Creased Conical Surfaces

    NASA Astrophysics Data System (ADS)

    Lechenault, F.; Adda-Bedia, M.

    2015-12-01

    The emerging field of mechanical metamaterials has sought inspiration in the ancient art of origami as archetypal deployable structures that carry geometric rigidity, exhibit exotic material properties, and are potentially scalable. A promising venue to introduce functionality consists in coupling the elasticity of the sheet and the kinematics of the folds. In this spirit, we introduce a scale-free, analytical description of a very general class of snap-through, bistable patterns of creases naturally occurring at the vertices of real origami that can be used as building blocks to program and actuate the overall shape of the decorated sheet. These switches appear at the simplest possible level of creasing and admit straightforward experimental realizations.

  15. Nonlinear Geometric Effects in Mechanical Bistable Morphing Structures

    NASA Astrophysics Data System (ADS)

    Chen, Zi; Guo, Qiaohang; Majidi, Carmel; Chen, Wenzhe; Srolovitz, David J.; Haataja, Mikko P.

    2012-09-01

    Bistable structures associated with nonlinear deformation behavior, exemplified by the Venus flytrap and slap bracelet, can switch between different functional shapes upon actuation. Despite numerous efforts in modeling such large deformation behavior of shells, the roles of mechanical and nonlinear geometric effects on bistability remain elusive. We demonstrate, through both theoretical analysis and tabletop experiments, that two dimensionless parameters control bistability. Our work classifies the conditions for bistability, and extends the large deformation theory of plates and shells.

  16. Bistable microvalve and microcatheter system

    DOEpatents

    Seward, Kirk Patrick

    2003-05-20

    A bistable microvalve of shape memory material is operatively connected to a microcatheter. The bistable microvalve includes a tip that can be closed off until it is in the desired position. Once it is in position it can opened and closed. The system uses heat and pressure to open and close the microvalve. The shape memory material will change stiffness and shape when heated above a transition temperature. The shape memory material is adapted to move from a first shape to a second shape, either open or closed, where it can perform a desired function.

  17. Generalized Bistability in Origami Cylinders

    NASA Astrophysics Data System (ADS)

    Reid, Austin; Adda-Bedia, Mokhtar; Lechenault, Frederic

    Origami folded cylinders (origami bellows) have found increasingly sophisticated applications in space flight, medicine, and even experimental nuclear physics. In spite of this interest, a general understanding of the dynamics of an origami folded cylinder has been elusive. By solving the fully constrained behavior of a periodic fundamental origami cell defined by unit vectors, we have found an analytic solution for all possible rigid-face states accessible from a cylindrical Miura-ori pattern. Although an idealized bellows has two rigid-face configurations over a well-defined region, a physical device, limited by nonzero material thickness and forced to balance hinge with plate-bending energy, often cannot stably maintain a stowed configuration. We have identified and measured the parameters which control this emergent bistability, and have demonstrated the ability to fabricate bellows with tunable deployability.

  18. Structures of mesophilic and extremophilic citrate synthases reveal rigidity and flexibility for function.

    PubMed

    Wells, Stephen A; Crennell, Susan J; Danson, Michael J

    2014-10-01

    Citrate synthase (CS) catalyses the entry of carbon into the citric acid cycle and is highly-conserved structurally across the tree of life. Crystal structures of dimeric CSs are known in both "open" and "closed" forms, which differ by a substantial domain motion that closes the substrate-binding clefts. We explore both the static rigidity and the dynamic flexibility of CS structures from mesophilic and extremophilic organisms from all three evolutionary domains. The computational expense of this wide-ranging exploration is kept to a minimum by the use of rigidity analysis and rapid all-atom simulations of flexible motion, combining geometric simulation and elastic network modeling. CS structures from thermophiles display increased structural rigidity compared with the mesophilic enzyme. A CS structure from a psychrophile, stabilized by strong ionic interactions, appears to display likewise increased rigidity in conventional rigidity analysis; however, a novel modified analysis, taking into account the weakening of the hydrophobic effect at low temperatures, shows a more appropriate decreased rigidity. These rigidity variations do not, however, affect the character of the flexible dynamics, which are well conserved across all the structures studied. Simulation trajectories not only duplicate the crystallographically observed symmetric open-to-closed transitions, but also identify motions describing a previously unidentified antisymmetric functional motion. This antisymmetric motion would not be directly observed in crystallography but is revealed as an intrinsic property of the CS structure by modeling of flexible motion. This suggests that the functional motion closing the binding clefts in CS may be independent rather than symmetric and cooperative.

  19. Qualification of frequency response functions using the rigid-body response

    SciTech Connect

    Smallwood, D.O.; Lauffer, J.P.

    1987-01-01

    The response of a structure at low frequencies with free boundary conditions is dominated by the rigid-body modes. The displacement shapes obtained from the low frequency values of the frequency response functions can be compared with ideal rigid-body motion to point out errors in the measurements. Insight is enhanced when the comparisons are made in the coordinate system of the measurements. Without this procedure intuition can rarely determine the proper rigid-body response at each measurement location. Typical errors identified are scaling errors, errors in location or direction, measurements with poor dynamic range and other instrumentation problems. The procedure is particularly useful when the test object is multidimensional, has a complicated geometry, has measurements in other than rectangular coordinates, and where more than one rigid-body mode is excited. It is suggested that data qualification using this method would be a useful addition to most modal tests. A least squares approach, to determine the proper rigid-body response, is reviewed and several experimental examples are given. 4 refs., 12 figs.

  20. Perceptual, cognitive, and personality rigidity in Parkinson's disease.

    PubMed

    Díaz-Santos, Mirella; Cao, Bo; Yazdanbakhsh, Arash; Norton, Daniel J; Neargarder, Sandy; Cronin-Golomb, Alice

    2015-03-01

    Parkinson's disease (PD) is associated with motor and non-motor rigidity symptoms (e.g., cognitive and personality). The question is raised as to whether rigidity in PD also extends to perception, and if so, whether perceptual, cognitive, and personality rigidities are correlated. Bistable stimuli were presented to 28 non-demented individuals with PD and 26 normal control adults (NC). Necker cube perception and binocular rivalry were examined during passive viewing, and the Necker cube was additionally used for two volitional-control conditions: Hold one percept in front, and Switch between the two percepts. Relative to passive viewing, PD were significantly less able than NC to reduce dominance durations in the Switch condition, indicating perceptual rigidity. Tests of cognitive flexibility and a personality questionnaire were administered to explore the association with perceptual rigidity. Cognitive flexibility was not correlated with perceptual rigidity for either group. Personality (novelty seeking) correlated with dominance durations on Necker passive viewing for PD but not NC. The results indicate the presence in mild-moderate PD of perceptual rigidity and suggest shared neural substrates with novelty seeking, but functional divergence from those supporting cognitive flexibility. The possibility is raised that perceptual rigidity may be a harbinger of cognitive inflexibility later in the disease course.

  1. Bistability and Bacterial Infections

    PubMed Central

    Malka, Roy; Shochat, Eliezer; Rom-Kedar, Vered

    2010-01-01

    Bacterial infections occur when the natural host defenses are overwhelmed by invading bacteria. The main component of the host defense is impaired when neutrophil count or function is too low, putting the host at great risk of developing an acute infection. In people with intact immune systems, neutrophil count increases during bacterial infection. However, there are two important clinical cases in which they remain constant: a) in patients with neutropenic-associated conditions, such as those undergoing chemotherapy at the nadir (the minimum clinically observable neutrophil level); b) in ex vivo examination of the patient's neutrophil bactericidal activity. Here we study bacterial population dynamics under fixed neutrophil levels by mathematical modelling. We show that under reasonable biological assumptions, there are only two possible scenarios: 1) Bacterial behavior is monostable: it always converges to a stable equilibrium of bacterial concentration which only depends, in a gradual manner, on the neutrophil level (and not on the initial bacterial level). We call such a behavior type I dynamics. 2) The bacterial dynamics is bistable for some range of neutrophil levels. We call such a behavior type II dynamics. In the bistable case (type II), one equilibrium corresponds to a healthy state whereas the other corresponds to a fulminant bacterial infection. We demonstrate that published data of in vitro Staphylococcus epidermidis bactericidal experiments are inconsistent with both the type I dynamics and the commonly used linear model and are consistent with type II dynamics. We argue that type II dynamics is a plausible mechanism for the development of a fulminant infection. PMID:20463954

  2. Brain networks underlying bistable perception.

    PubMed

    Baker, Daniel H; Karapanagiotidis, Theodoros; Coggan, David D; Wailes-Newson, Kirstie; Smallwood, Jonathan

    2015-10-01

    Bistable stimuli, such as the Necker Cube, demonstrate that experience can change in the absence of changes in the environment. Such phenomena can be used to assess stimulus-independent aspects of conscious experience. The current study used resting state functional magnetic resonance imaging (rs-fMRI) to index stimulus-independent changes in neural activity to understand the neural architecture that determines dominance durations during bistable perception (using binocular rivalry and Necker cube stimuli). Anterior regions of the Superior Parietal Lobule (SPL) exhibited robust connectivity with regions of primary sensorimotor cortex. The strength of this region's connectivity with the striatum predicted shorter dominance durations during binocular rivalry, whereas its connectivity to pre-motor cortex predicted longer dominance durations for the Necker Cube. Posterior regions of the SPL, on the other hand, were coupled to associative cortex in the temporal and frontal lobes. The posterior SPL's connectivity to the temporal lobe predicted longer dominance during binocular rivalry. In conjunction with prior work, these data suggest that the anterior SPL contributes to perceptual rivalry through the inhibition of incongruent bottom up information, whereas the posterior SPL influences rivalry by supporting the current interpretation of a bistable stimulus. Our data suggests that the functional connectivity of the SPL with regions of sensory, motor, and associative cortex allows it to regulate the interpretation of the environment that forms the focus of conscious attention at a specific moment in time.

  3. Brain networks underlying bistable perception.

    PubMed

    Baker, Daniel H; Karapanagiotidis, Theodoros; Coggan, David D; Wailes-Newson, Kirstie; Smallwood, Jonathan

    2015-10-01

    Bistable stimuli, such as the Necker Cube, demonstrate that experience can change in the absence of changes in the environment. Such phenomena can be used to assess stimulus-independent aspects of conscious experience. The current study used resting state functional magnetic resonance imaging (rs-fMRI) to index stimulus-independent changes in neural activity to understand the neural architecture that determines dominance durations during bistable perception (using binocular rivalry and Necker cube stimuli). Anterior regions of the Superior Parietal Lobule (SPL) exhibited robust connectivity with regions of primary sensorimotor cortex. The strength of this region's connectivity with the striatum predicted shorter dominance durations during binocular rivalry, whereas its connectivity to pre-motor cortex predicted longer dominance durations for the Necker Cube. Posterior regions of the SPL, on the other hand, were coupled to associative cortex in the temporal and frontal lobes. The posterior SPL's connectivity to the temporal lobe predicted longer dominance during binocular rivalry. In conjunction with prior work, these data suggest that the anterior SPL contributes to perceptual rivalry through the inhibition of incongruent bottom up information, whereas the posterior SPL influences rivalry by supporting the current interpretation of a bistable stimulus. Our data suggests that the functional connectivity of the SPL with regions of sensory, motor, and associative cortex allows it to regulate the interpretation of the environment that forms the focus of conscious attention at a specific moment in time. PMID:26123379

  4. Functional Outcome Following Arthroscopic ACL Reconstruction with Rigid Fix: A Retrospective Observational Study

    PubMed Central

    Shervegar, Satish; Nagaraj, Prashanth; Grover, Amit; DJ, Niranthara Ganesh; Ravoof, Abdul

    2015-01-01

    Background: No uniform consensus exists to decide type of fixation for arthroscopic anterior cruciate ligament reconstruction. Hypothsis: There is similar functional outcome after rigid fix compared to other methods of fixation which has been published. Study design: Retrospective observational study. Methods: A total of 50 patients underwent arthroscopic anterior cruciate ligament reconstruction with hamstring tendons using femoral Rigid fix cross-pin and interference screw tibial fixation. The evaluation methods were clinical examination, IKDC scores, Lysholm and pre injury and post reconstruction Tegner score. Patients were followed up from minimum of 6 months to 4 year seven months. Results: C In our study of sample size 50 we found that mean age of patients was 30.8 Years with male preponderance. Mean post operative IKDC and Lysholm score has been 75.6 and 84.4 respectively. Mean Tegner pre-injury score and post reconstruction score has been 5.4 and 4.26. Box plot comparison of pre injury and post operativeTegner score reveals a statistically significant difference with respect to paired t test P<0.001. Conclusions: Arthroscopic anterior cruciate ligament reconstruction with femoral rigid fix cross pins and tibial interference screws results in comparable short term to midterm functional results compared to other types of fixation PMID:26550591

  5. Bistability in Apoptosis by Receptor Clustering

    PubMed Central

    Ho, Kenneth L.; Harrington, Heather A.

    2010-01-01

    Apoptosis is a highly regulated cell death mechanism involved in many physiological processes. A key component of extrinsically activated apoptosis is the death receptor Fas which, on binding to its cognate ligand FasL, oligomerize to form the death-inducing signaling complex. Motivated by recent experimental data, we propose a mathematical model of death ligand-receptor dynamics where FasL acts as a clustering agent for Fas, which form locally stable signaling platforms through proximity-induced receptor interactions. Significantly, the model exhibits hysteresis, providing an upstream mechanism for bistability and robustness. At low receptor concentrations, the bistability is contingent on the trimerism of FasL. Moreover, irreversible bistability, representing a committed cell death decision, emerges at high concentrations which may be achieved through receptor pre-association or localization onto membrane lipid rafts. Thus, our model provides a novel theory for these observed biological phenomena within the unified context of bistability. Importantly, as Fas interactions initiate the extrinsic apoptotic pathway, our model also suggests a mechanism by which cells may function as bistable life/death switches independently of any such dynamics in their downstream components. Our results highlight the role of death receptors in deciding cell fate and add to the signal processing capabilities attributed to receptor clustering. PMID:20976242

  6. Bistable Microvalve For Use With Microcatheter System

    DOEpatents

    Seward, Kirk Patrick

    2003-12-16

    A bistable microvalve of shape memory material is operatively connected to a microcatheter. The bistable microvalve includes a tip that can be closed off until it is in the desired position. Once it is in position it can be opened and closed. The system uses heat and pressure to open and close the microvalve. The shape memory material will change stiffness and shape when heated above a transition temperature. The shape memory material is adapted to move from a first shape to a second shape, either open or closed, where it can perform a desired function.

  7. Bistability, mushrooms, and isolas

    NASA Astrophysics Data System (ADS)

    Ganapathisubramanian, N.; Showalter, Kenneth

    1984-05-01

    The iodate oxidation of arsenous acid exhibits single-hysteresis bistability in a continuous flow stirred tank reactor. Other patterns of multiple stationary states including mushrooms and isolas are exhibited by this system when a constant flow of solvent is introduced to the CSTR in addition to the usual flow of reactants. A simple empirical rate law model provides a near quantitative description of the behavior. This model is analyzed and compared to other model systems.

  8. Bistable microelectromechanical actuator

    DOEpatents

    Fleming, James G.

    1999-01-01

    A bistable microelectromechanical (MEM) actuator is formed on a substrate and includes a stressed membrane of generally rectangular shape that upon release assumes a curvilinear cross-sectional shape due to attachment at a midpoint to a resilient member and at opposing edges to a pair of elongate supports. The stressed membrane can be electrostatically switched between a pair of mechanical states having mirror-image symmetry, with the MEM actuator remaining in a quiescent state after a programming voltage is removed. The bistable MEM actuator according to various embodiments of the present invention can be used to form a nonvolatile memory element, an optical modulator (with a pair of mirrors supported above the membrane and moving in synchronism as the membrane is switched), a switchable mirror (with a single mirror supported above the membrane at the midpoint thereof) and a latching relay (with a pair of contacts that open and close as the membrane is switched). Arrays of bistable MEM actuators can be formed for applications including nonvolatile memories, optical displays and optical computing.

  9. Bistable microelectromechanical actuator

    DOEpatents

    Fleming, J.G.

    1999-02-02

    A bistable microelectromechanical (MEM) actuator is formed on a substrate and includes a stressed membrane of generally rectangular shape that upon release assumes a curvilinear cross-sectional shape due to attachment at a midpoint to a resilient member and at opposing edges to a pair of elongate supports. The stressed membrane can be electrostatically switched between a pair of mechanical states having mirror-image symmetry, with the MEM actuator remaining in a quiescent state after a programming voltage is removed. The bistable MEM actuator according to various embodiments of the present invention can be used to form a nonvolatile memory element, an optical modulator (with a pair of mirrors supported above the membrane and moving in synchronism as the membrane is switched), a switchable mirror (with a single mirror supported above the membrane at the midpoint thereof) and a latching relay (with a pair of contacts that open and close as the membrane is switched). Arrays of bistable MEM actuators can be formed for applications including nonvolatile memories, optical displays and optical computing. 49 figs.

  10. Synergistic regulation of cell function by matrix rigidity and adhesive pattern

    PubMed Central

    Weng, Shinuo; Fu, Jianping

    2014-01-01

    Cell-extracellular matrix (ECM) interactions play a critical role in regulating cellular behaviors. Recent studies of cell-ECM interactions have mainly focused on the actomyosin based and adhesion mediated mechanosensing pathways to understand how individual mechanical signals in the cell microenvironment, such as matrix rigidity and adhesive ECM pattern, are sensed by the cell and further trigger downstream intracellular signaling cascades and cellular responses. However, synergistic and collective regulation of cellular behaviors by matrix rigidity and adhesive ECM pattern are still elusive and largely uncharacterized. Here, we generated a library of microfabricated polydimethylsiloxane (PDMS) micropost arrays to study the synergistic and independent effects of matrix rigidity and adhesive ECM pattern on mechanoresponsive behaviors of both NIH/3T3 fibroblasts and human umbilical vein endothelial cells (HUVECs). We showed that both cell types were mechanosensitive and their cell spreading, FA formation, cytoskeletal contractility, and proliferation were all strongly dependent on both substrate rigidity and adhesive ECM pattern. We further showed that under the same substrate rigidity condition, smaller and closer adhesive ECM islands would cause both cells to spread out more, form more adhesion structures, and have a higher proliferation rate. The influence of adhesive ECM pattern on rigidity-mediated cytoskeletal contractility was cell type specific and was only significant for NIH/3T3. Morphometric analysis of cell populations revealed a strong correlation between focal adhesion and cell spreading, regardless of substrate rigidity and adhesive ECM pattern. We also observed a strong correlation between cellular traction force and cell spreading, with a substantially smaller independent effect of substrate rigidity on traction force. Our study here had determined key aspects of the biomechanical responses of adherent cells to independent and collective changes of

  11. The Relation of Rigidity across Relationships with Symptoms and Functioning: An Investigation with the Revised Central Relationship Questionnaire

    ERIC Educational Resources Information Center

    McCarthy, Kevin S.; Gibbons, Mary Beth Connolly; Barber, Jacques P.

    2008-01-01

    The belief that rigidity across relationships is related to greater symptoms and poorer functioning commonly informs the practice of many psychodynamic and interpersonal therapists. Using a profile correlation approach, the authors tested this hypothesis in a sample of 250 clients and 90 undergraduate control participants. Symptoms and functioning…

  12. Structure-Function Relations and Rigidity Percolation in the Shear Properties of Articular Cartilage

    PubMed Central

    Silverberg, Jesse L.; Barrett, Aliyah R.; Das, Moumita; Petersen, Poul B.; Bonassar, Lawrence J.; Cohen, Itai

    2014-01-01

    Among mammalian soft tissues, articular cartilage is particularly interesting because it can endure a lifetime of daily mechanical loading despite having minimal regenerative capacity. This remarkable resilience may be due to the depth-dependent mechanical properties, which have been shown to localize strain and energy dissipation. This paradigm proposes that these properties arise from the depth-dependent collagen fiber orientation. Nevertheless, this structure-function relationship has not yet been quantified. Here, we use confocal elastography, quantitative polarized light microscopy, and Fourier-transform infrared imaging to make same-sample measurements of the depth-dependent shear modulus, collagen fiber organization, and extracellular matrix concentration in neonatal bovine articular cartilage. We find weak correlations between the shear modulus |G∗| and both the collagen fiber orientation and polarization. We find a much stronger correlation between |G∗| and the concentration of collagen fibers. Interestingly, very small changes in collagen volume fraction vc lead to orders-of-magnitude changes in the modulus with |G∗| scaling as (vc – v0)ξ. Such dependencies are observed in the rheology of other biopolymer networks whose structure exhibits rigidity percolation phase transitions. Along these lines, we propose that the collagen network in articular cartilage is near a percolation threshold that gives rise to these large mechanical variations and localization of strain at the tissue’s surface. PMID:25296326

  13. The rigid bi-functional sail, new concept concerning the reduction of the drag of ships

    NASA Astrophysics Data System (ADS)

    Țicu, I.; Popa, I.; Ristea, M.

    2015-11-01

    The policy of the European Union in the energy field, for the period to follow until 2020, is based on three fundamental objectives: sustainability, competitiveness and safety in energy supply. The “Energy - Climate Changes” program sets out a number of objectives for the EU for the year 2020, known as the “20-20-20 objectives”, namely: the reduction of greenhouse gas emissions by at least 20% from the level of those of 1990, a 20% increase in the share of renewable energy sources out of the total energy consumption as well as a target of 10% biofuels in the transports energy consumption. In this context, in order to produce or save a part of the propulsive power produced by the main propulsion machinery, by burning fossil fuels, we suggest the equipping of vessels designed for maritime transport with a bi-functional rigid sail. We consider that this device may have both the role of trapping wind energy and the role of acting as a deflector for reducing the resistance of the vessel's proceeding through the water by conveniently using the bow air current, as a result of the vessel's heading through the water with significant advantage in reducing the energy consumption for propulsion insurance.

  14. Optical bistability in semiconductor microcavities

    SciTech Connect

    Baas, A.; Karr, J.Ph.; Giacobino, E.; Eleuch, H.

    2004-02-01

    We report the observation of polaritonic bistability in semiconductor microcavities in the strong-coupling regime. The origin of bistability is the polariton-polariton interaction, which gives rise to a Kerr-like nonlinearity. The experimental results are in good agreement with a simple model taking transverse effects into account.

  15. Aquatic turning performance of painted turtles (Chrysemys picta) and functional consequences of a rigid body design.

    PubMed

    Rivera, Gabriel; Rivera, Angela R V; Dougherty, Erin E; Blob, Richard W

    2006-11-01

    The ability to capture prey and avoid predation in aquatic habitats depends strongly on the ability to perform unsteady maneuvers (e.g. turns), which itself depends strongly on body flexibility. Two previous studies of turning performance in rigid-bodied taxa have found either high maneuverability or high agility, but not both. However, examinations of aquatic turning performance in rigid-bodied animals have had limited taxonomic scope and, as such, the effects of many body shapes and designs on aquatic maneuverability and agility have yet to be examined. Turtles represent the oldest extant lineage of rigid-bodied vertebrates and the only aquatic rigid-bodied tetrapods. We evaluated the aquatic turning performance of painted turtles, Chrysemys picta (Schneider, 1783) using the minimum length-specific radius of the turning path (R/L) and the average turning rate (omega(avg)) as measures of maneuverability and agility, respectively. We filmed turtles conducting forward and backward turns in an aquatic arena. Each type of turn was executed using a different pattern of limb movements. During forward turns, turtles consistently protracted the inboard forelimb and held it stationary into the flow, while continuing to move the outboard forelimb and both hindlimbs as in rectilinear swimming. The limb movements of backward turns were more complex than those of forward turns, but involved near simultaneous retraction and protraction of contralateral fore- and hindlimbs, respectively. Forward turns had a minimum R/L of 0.0018 (the second single lowest value reported from any animal) and a maximum omega(avg) of 247.1 degrees. Values of R/L for backward turns (0.0091-0.0950 L) were much less variable than that of forward turns (0.0018-1.0442 L). The maneuverability of turtles is similar to that recorded previously for rigid-bodied boxfish. However, several morphological features of turtles (e.g. shell morphology and limb position) appear to increase agility relative to the body

  16. Bistable mechanisms for morphing rotors

    NASA Astrophysics Data System (ADS)

    Johnson, Terrence; Gandhi, Farhan; Frecker, Mary

    2008-03-01

    In this paper we explore the use of bistable mechanisms for rotor morphing, specifically, blade tip twist. The optimal blade twist distributions for hover and high-speed forward flight are very different, and the ability of the rotor to change effective twist is expected to be advantageous. Bistable or "snap-through" mechanisms have multiple stable equilibrium states and are a novel way to achieve large actuation output stroke at relatively modest effort for gross rotor morphing applications. This is because in addition to the large actuation stroke associated with the snap-through (relative to conventional actuator/ amplification systems) coming at relatively low actuation effort, no locking is required in either equilibrium state (since they are both stable). In this work, the performance of a bistable twisting device is evaluated under an aerodynamic lift load. The device is analyzed using finite element analysis to predict the device's load carrying capability and bistable behavior.

  17. Temporal nonlocality in bistable perception

    NASA Astrophysics Data System (ADS)

    Atmanspacher, Harald; Filk, Thomas

    2012-12-01

    A novel conceptual framework for theoretical psychology is presented and illustrated for the example of bistable perception. A basic formal feature of this framework is the non-commutativity of operations acting on mental states. A corresponding model for the bistable perception of ambiguous stimuli, the Necker-Zeno model, is sketched and some empirical evidence for it so far is described. It is discussed how a temporal nonlocality of mental states, predicted by the model, can be understood and tested.

  18. Aquatic turning performance of painted turtles (Chrysemys picta) and functional consequences of a rigid body design.

    PubMed

    Rivera, Gabriel; Rivera, Angela R V; Dougherty, Erin E; Blob, Richard W

    2006-11-01

    The ability to capture prey and avoid predation in aquatic habitats depends strongly on the ability to perform unsteady maneuvers (e.g. turns), which itself depends strongly on body flexibility. Two previous studies of turning performance in rigid-bodied taxa have found either high maneuverability or high agility, but not both. However, examinations of aquatic turning performance in rigid-bodied animals have had limited taxonomic scope and, as such, the effects of many body shapes and designs on aquatic maneuverability and agility have yet to be examined. Turtles represent the oldest extant lineage of rigid-bodied vertebrates and the only aquatic rigid-bodied tetrapods. We evaluated the aquatic turning performance of painted turtles, Chrysemys picta (Schneider, 1783) using the minimum length-specific radius of the turning path (R/L) and the average turning rate (omega(avg)) as measures of maneuverability and agility, respectively. We filmed turtles conducting forward and backward turns in an aquatic arena. Each type of turn was executed using a different pattern of limb movements. During forward turns, turtles consistently protracted the inboard forelimb and held it stationary into the flow, while continuing to move the outboard forelimb and both hindlimbs as in rectilinear swimming. The limb movements of backward turns were more complex than those of forward turns, but involved near simultaneous retraction and protraction of contralateral fore- and hindlimbs, respectively. Forward turns had a minimum R/L of 0.0018 (the second single lowest value reported from any animal) and a maximum omega(avg) of 247.1 degrees. Values of R/L for backward turns (0.0091-0.0950 L) were much less variable than that of forward turns (0.0018-1.0442 L). The maneuverability of turtles is similar to that recorded previously for rigid-bodied boxfish. However, several morphological features of turtles (e.g. shell morphology and limb position) appear to increase agility relative to the body

  19. Fitting properties from density functional theory based molecular dynamics simulations to parameterize a rigid water force field

    NASA Astrophysics Data System (ADS)

    Sala, Jonàs; Guàrdia, Elvira; Martí, Jordi; Spângberg, Daniel; Masia, Marco

    2012-02-01

    In the quest towards coarse-grained potentials and new water models, we present an extension of the force matching technique to parameterize an all-atom force field for rigid water. The methodology presented here allows to improve the matching procedure by first optimizing the weighting exponents present in the objective function. A new gauge for unambiguously evaluating the quality of the fit has been introduced; it is based on the root mean square difference of the distributions of target properties between reference data and fitted potentials. Four rigid water models have been parameterized; the matching procedure has been used to assess the role of the ghost atom in TIP4P-like models and of electrostatic damping. In the former case, burying the negative charge inside the molecule allows to fit better the torques. In the latter, since short-range interactions are damped, a better fit of the forces is obtained. Overall, the best performing model is the one with a ghost atom and with electrostatic damping. The approach shown in this paper is of general validity and could be applied to any matching algorithm and to any level of coarse graining, also for non-rigid molecules.

  20. Abdominal rigidity

    MedlinePlus

    Rigidity of the abdomen ... is a sore area inside the belly or abdomen, the pain will get worse when a hand ... Causes can include: Abscess inside the abdomen Appendicitis ... small intestine, large bowel, or gallbladder ( gastrointestinal ...

  1. Optically bistable interference filter

    NASA Astrophysics Data System (ADS)

    Feng, Weiting

    1990-07-01

    In general the temperature dependence of refractive index of coating materials is usually small. The most notable exception being the lead telluride. Thinfilm filters made of PbTe possess anomalously high nortlinearily in refractive index. We have investigated the phenomenon theoretically and experimexitally. 2 . BISTABLE CHARACTERISTICS OF INTERFERENCE FILTERS It can be proved that the transmittance and reflectance of a twin-cavity NLIF which consists of two F-B filters coupled by a single low-index are given by 2 a(1r1 )(1-r0) T --i. -. (1) -d (1r01) (1r12) (1-i-Fsin 4)(1+sin p) where a r01 F . Te phase change of the cavity 0 IS 2r0dnAI0D (2) 2k5dT 1k where the absorbtance A 00 the initial detunning of fresonance and the first term on the right side of the equation(1)-(2) the output characteristics of the NLIF can be calculated. 3 . EXPERIMENTAL CASE The interference filters suggested to be used in my research will be made by vacuum deposition with a thermal source. The filters will be made according to the prescripti The dominant mechanism responsible for d(nhl) must be the change in the refractive index. A low limit on the OB switch-on time is found to be O. 35us and switch-off time is 5. 5us. 4. REFERENCES 1. W. T. Feng " Temperature effects on properties of zinc selenide and lead telluride" to be published in Infrared Physics. 2. H. S. Carslaw Conduction

  2. Reentrant Origami-Based Metamaterials with Negative Poisson's Ratio and Bistability

    NASA Astrophysics Data System (ADS)

    Yasuda, H.; Yang, J.

    2015-05-01

    We investigate the unique mechanical properties of reentrant 3D origami structures based on the Tachi-Miura polyhedron (TMP). We explore the potential usage as mechanical metamaterials that exhibit tunable negative Poisson's ratio and structural bistability simultaneously. We show analytically and experimentally that the Poisson's ratio changes from positive to negative and vice versa during its folding motion. In addition, we verify the bistable mechanism of the reentrant 3D TMP under rigid origami configurations without relying on the buckling motions of planar origami surfaces. This study forms a foundation in designing and constructing TMP-based metamaterials in the form of bellowslike structures for engineering applications.

  3. Obituary--rigid contact lenses.

    PubMed

    Efron, Nathan

    2010-10-01

    Scleral and corneal rigid lenses represented 100 per cent of the contact lens market immediately prior to the invention of soft lenses in the mid-1960s. In the United Kingdom today, rigid lenses comprise 2 per cent of all new lens fits. Low rates of rigid lens fitting are also apparent in 27 other countries which have recently been surveyed. Thus, the 1998 prediction of the author that rigid lenses--also referred to as 'rigid gas permeable' (RGP) lenses or 'gas permeable' (GP) lenses--would be obsolete by the year 2010 has essentially turned out to be correct. In this obituary, the author offers 10 reasons for the demise of rigid lens fitting: initial rigid lens discomfort; intractable rigid lens-induced corneal and lid pathology; extensive soft lens advertising; superior soft lens fitting logistics; lack of rigid lens training opportunities; redundancy of the rigid lens 'problem solver' function; improved soft toric and bifocal/varifocal lenses; limited uptake of orthokeratology; lack of investment in rigid lenses; and the emergence of aberration control soft lenses. Rigid lenses are now being fitted by a minority of practitioners with specialist skills/training. Certainly, rigid lenses can no longer be considered as a mainstream form of contact lens correction. May their dear souls (bulk properties) rest in peace. PMID:20674469

  4. Optical-fiber-coupled optical bistable semiconductor lasers

    SciTech Connect

    Zhing Lichen; Tang Yunxin; Qin Ying; Guo Yili

    1986-12-01

    A compact, low input power optical bistable device, consisting of a photodetector, an optical fiber directional coupler, and a semiconductor laser diode, was presented. The principle is described graphically to explain the observed effects such as hysteresis, differential operational gain and memory functions.

  5. Design of a bistable switch to control cellular uptake.

    PubMed

    Oyarzún, Diego A; Chaves, Madalena

    2015-12-01

    Bistable switches are widely used in synthetic biology to trigger cellular functions in response to environmental signals. All bistable switches developed so far, however, control the expression of target genes without access to other layers of the cellular machinery. Here, we propose a bistable switch to control the rate at which cells take up a metabolite from the environment. An uptake switch provides a new interface to command metabolic activity from the extracellular space and has great potential as a building block in more complex circuits that coordinate pathway activity across cell cultures, allocate metabolic tasks among different strains or require cell-to-cell communication with metabolic signals. Inspired by uptake systems found in nature, we propose to couple metabolite import and utilization with a genetic circuit under feedback regulation. Using mathematical models and analysis, we determined the circuit architectures that produce bistability and obtained their design space for bistability in terms of experimentally tuneable parameters. We found an activation-repression architecture to be the most robust switch because it displays bistability for the largest range of design parameters and requires little fine-tuning of the promoters' response curves. Our analytic results are based on on-off approximations of promoter activity and are in excellent qualitative agreement with simulations of more realistic models. With further analysis and simulation, we established conditions to maximize the parameter design space and to produce bimodal phenotypes via hysteresis and cell-to-cell variability. Our results highlight how mathematical analysis can drive the discovery of new circuits for synthetic biology, as the proposed circuit has all the hallmarks of a toggle switch and stands as a promising design to control metabolic phenotypes across cell cultures. PMID:26674196

  6. Determinants of bistability in induction of the Escherichia coli lac operon.

    PubMed

    Dreisigmeyer, D W; Stajic, J; Nemenman, I; Hlavacek, W S; Wall, M E

    2008-09-01

    The authors have developed a mathematical model of regulation of expression of the Escherichia coli lac operon, and have investigated bistability in its steady-state induction behaviour in the absence of external glucose. Numerical analysis of equations describing regulation by artificial inducers revealed two natural bistability parameters that can be used to control the range of inducer concentrations over which the model exhibits bistability. By tuning these bistability parameters, the authors found a family of biophysically reasonable systems that are consistent with an experimentally determined bistable region for induction by thio-methylgalactoside (TMG) (in Ozbudak et al. Nature, 2004, 427; p. 737). To model regulation by lactose, the authors developed similar equations in which allolactose, a metabolic intermediate in lactose metabolism and a natural inducer of lac, is the inducer. For biophysically reasonable parameter values, these equations yield no bistability in response to induction by lactose - only systems with an unphysically small permease-dependent export effect can exhibit small amounts of bistability for limited ranges of parameter values. These results cast doubt on the relevance of bistability in the lac operon within the natural context of E. coli, and help shed light on the controversy among existing theoretical studies that address this issue. The results also motivate a deeper experimental characterisation of permease-independent transport of lac inducers, and suggest an experimental approach to address the relevance of bistability in the lac operon within the natural context of E. coli. The sensitivity of lac bistability to the type of inducer emphasises the importance of metabolism in determining the functions of genetic regulatory networks. PMID:19045824

  7. Bi-stable optical actuator

    DOEpatents

    Holdener, Fred R.; Boyd, Robert D.

    2000-01-01

    The present invention is a bi-stable optical actuator device that is depowered in both stable positions. A bearing is used to transfer motion and smoothly transition from one state to another. The optical actuator device may be maintained in a stable position either by gravity or a restraining device.

  8. Flexible Bistable Cholesteric Reflective Displays

    NASA Astrophysics Data System (ADS)

    Yang, Deng-Ke

    2006-03-01

    Cholesteric liquid crystals (ChLCs) exhibit two stable states at zero field condition-the reflecting planar state and the nonreflecting focal conic state. ChLCs are an excellent candidate for inexpensive and rugged electronic books and papers. This paper will review the display cell structure,materials and drive schemes for flexible bistable cholesteric (Ch) reflective displays.

  9. Launch and Functional Considerations Guiding the Scaling and Design of Rigid Inflatable Habitat Modules

    NASA Astrophysics Data System (ADS)

    Bell, L.

    2002-01-01

    The Sasakawa International Center for Space Architecture (SICSA) has a long history of projects that involve design of space structures, including habitats for low-Earth orbit (LEO) and planetary applications. Most of these facilities and component systems are planned to comply with size, geometry and mass restrictions imposed by the Space Shuttle Orbiter's payload and lift/landing abort restrictions. These constraints limit launch elements to approximately 15 ft. diameter, 40 ft. long cylindrical dimensions weighing no more than approximately 25 metric tons. It is clear that future success of commercial space programs such as tourism will hinge upon the availability of bigger and more efficient Earth to LEO launch vehicles which can greatly reduce transportation and operational costs. This will enable development and utilization of larger habitat modules and other infrastructure elements which can be deployed with fewer launches and on-orbit assembly procedures. The sizing of these new heavy lift launchers should be scaled to optimize habitat functionality and efficiency, just as the habitat designs must consider optimization of launch vehicle economy. SICSA's planning studies address these vehicle and habitat optimization priorities as parallel and interdependent considerations. The allowable diameter of habitat modules established by launch vehicle capacity dictates functionally acceptable internal configuration options. Analyses of these options relative to practical dimensions for Earth-to-orbit launch vehicle scaling were conducted for two general schemes. The "bologna slice" configuration stacks the floors within a predominately cylindrical or spherical envelope, producing circular areas. The "banana split" approach divides a cylindrical module longitudinally, creating floors that are generally rectangular in shape. The assessments established minimum sizes for reasonable utility and efficiency. The bologna slice option. This configuration is only acceptable

  10. Pair mobility functions for rigid spheres in concentrated colloidal dispersions: Force, torque, translation, and rotation

    NASA Astrophysics Data System (ADS)

    Zia, Roseanna N.; Swan, James W.; Su, Yu

    2015-12-01

    The formulation of detailed models for the dynamics of condensed soft matter including colloidal suspensions and other complex fluids requires accurate description of the physical forces between microstructural constituents. In dilute suspensions, pair-level interactions are sufficient to capture hydrodynamic, interparticle, and thermodynamic forces. In dense suspensions, many-body interactions must be considered. Prior analytical approaches to capturing such interactions such as mean-field approaches replace detailed interactions with averaged approximations. However, long-range coupling and effects of concentration on local structure, which may play an important role in, e.g., phase transitions, are smeared out in such approaches. An alternative to such approximations is the detailed modeling of hydrodynamic interactions utilizing precise couplings between moments of the hydrodynamic traction on a suspended particle and the motion of that or other suspended particles. For two isolated spheres, a set of these functions was calculated by Jeffrey and Onishi [J. Fluid Mech. 139, 261-290 (1984)] and Jeffrey [J. Phys. Fluids 4, 16-29 (1992)]. Along with pioneering work by Batchelor, these are the touchstone for low-Reynolds-number hydrodynamic interactions and have been applied directly in the solution of many important problems related to the dynamics of dilute colloidal dispersions [G. K. Batchelor and J. T. Green, J. Fluid Mech. 56, 375-400 (1972) and G. K. Batchelor, J. Fluid Mech. 74, 1-29 (1976)]. Toward extension of these functions to concentrated systems, here we present a new stochastic sampling technique to rapidly calculate an analogous set of mobility functions describing the hydrodynamic interactions between two hard spheres immersed in a suspension of arbitrary concentration, utilizing accelerated Stokesian dynamics simulations. These mobility functions provide precise, radially dependent couplings of hydrodynamic force and torque to particle translation

  11. Pair mobility functions for rigid spheres in concentrated colloidal dispersions: Force, torque, translation, and rotation

    SciTech Connect

    Zia, Roseanna N. Su, Yu; Swan, James W.

    2015-12-14

    The formulation of detailed models for the dynamics of condensed soft matter including colloidal suspensions and other complex fluids requires accurate description of the physical forces between microstructural constituents. In dilute suspensions, pair-level interactions are sufficient to capture hydrodynamic, interparticle, and thermodynamic forces. In dense suspensions, many-body interactions must be considered. Prior analytical approaches to capturing such interactions such as mean-field approaches replace detailed interactions with averaged approximations. However, long-range coupling and effects of concentration on local structure, which may play an important role in, e.g., phase transitions, are smeared out in such approaches. An alternative to such approximations is the detailed modeling of hydrodynamic interactions utilizing precise couplings between moments of the hydrodynamic traction on a suspended particle and the motion of that or other suspended particles. For two isolated spheres, a set of these functions was calculated by Jeffrey and Onishi [J. Fluid Mech. 139, 261–290 (1984)] and Jeffrey [J. Phys. Fluids 4, 16–29 (1992)]. Along with pioneering work by Batchelor, these are the touchstone for low-Reynolds-number hydrodynamic interactions and have been applied directly in the solution of many important problems related to the dynamics of dilute colloidal dispersions [G. K. Batchelor and J. T. Green, J. Fluid Mech. 56, 375–400 (1972) and G. K. Batchelor, J. Fluid Mech. 74, 1–29 (1976)]. Toward extension of these functions to concentrated systems, here we present a new stochastic sampling technique to rapidly calculate an analogous set of mobility functions describing the hydrodynamic interactions between two hard spheres immersed in a suspension of arbitrary concentration, utilizing accelerated Stokesian dynamics simulations. These mobility functions provide precise, radially dependent couplings of hydrodynamic force and torque to particle

  12. Pair mobility functions for rigid spheres in concentrated colloidal dispersions: Force, torque, translation, and rotation.

    PubMed

    Zia, Roseanna N; Swan, James W; Su, Yu

    2015-12-14

    The formulation of detailed models for the dynamics of condensed soft matter including colloidal suspensions and other complex fluids requires accurate description of the physical forces between microstructural constituents. In dilute suspensions, pair-level interactions are sufficient to capture hydrodynamic, interparticle, and thermodynamic forces. In dense suspensions, many-body interactions must be considered. Prior analytical approaches to capturing such interactions such as mean-field approaches replace detailed interactions with averaged approximations. However, long-range coupling and effects of concentration on local structure, which may play an important role in, e.g., phase transitions, are smeared out in such approaches. An alternative to such approximations is the detailed modeling of hydrodynamic interactions utilizing precise couplings between moments of the hydrodynamic traction on a suspended particle and the motion of that or other suspended particles. For two isolated spheres, a set of these functions was calculated by Jeffrey and Onishi [J. Fluid Mech. 139, 261-290 (1984)] and Jeffrey [J. Phys. Fluids 4, 16-29 (1992)]. Along with pioneering work by Batchelor, these are the touchstone for low-Reynolds-number hydrodynamic interactions and have been applied directly in the solution of many important problems related to the dynamics of dilute colloidal dispersions [G. K. Batchelor and J. T. Green, J. Fluid Mech. 56, 375-400 (1972) and G. K. Batchelor, J. Fluid Mech. 74, 1-29 (1976)]. Toward extension of these functions to concentrated systems, here we present a new stochastic sampling technique to rapidly calculate an analogous set of mobility functions describing the hydrodynamic interactions between two hard spheres immersed in a suspension of arbitrary concentration, utilizing accelerated Stokesian dynamics simulations. These mobility functions provide precise, radially dependent couplings of hydrodynamic force and torque to particle translation

  13. Pair mobility functions for rigid spheres in concentrated colloidal dispersions: Force, torque, translation, and rotation.

    PubMed

    Zia, Roseanna N; Swan, James W; Su, Yu

    2015-12-14

    The formulation of detailed models for the dynamics of condensed soft matter including colloidal suspensions and other complex fluids requires accurate description of the physical forces between microstructural constituents. In dilute suspensions, pair-level interactions are sufficient to capture hydrodynamic, interparticle, and thermodynamic forces. In dense suspensions, many-body interactions must be considered. Prior analytical approaches to capturing such interactions such as mean-field approaches replace detailed interactions with averaged approximations. However, long-range coupling and effects of concentration on local structure, which may play an important role in, e.g., phase transitions, are smeared out in such approaches. An alternative to such approximations is the detailed modeling of hydrodynamic interactions utilizing precise couplings between moments of the hydrodynamic traction on a suspended particle and the motion of that or other suspended particles. For two isolated spheres, a set of these functions was calculated by Jeffrey and Onishi [J. Fluid Mech. 139, 261-290 (1984)] and Jeffrey [J. Phys. Fluids 4, 16-29 (1992)]. Along with pioneering work by Batchelor, these are the touchstone for low-Reynolds-number hydrodynamic interactions and have been applied directly in the solution of many important problems related to the dynamics of dilute colloidal dispersions [G. K. Batchelor and J. T. Green, J. Fluid Mech. 56, 375-400 (1972) and G. K. Batchelor, J. Fluid Mech. 74, 1-29 (1976)]. Toward extension of these functions to concentrated systems, here we present a new stochastic sampling technique to rapidly calculate an analogous set of mobility functions describing the hydrodynamic interactions between two hard spheres immersed in a suspension of arbitrary concentration, utilizing accelerated Stokesian dynamics simulations. These mobility functions provide precise, radially dependent couplings of hydrodynamic force and torque to particle translation

  14. Rigid and remodelled: cerebrovascular structure and function after experimental high-thoracic spinal cord transection.

    PubMed

    Phillips, A A; Matin, N; Frias, B; Zheng, M M Z; Jia, M; West, C; Dorrance, A M; Laher, I; Krassioukov, A V

    2016-03-15

    High-thoracic or cervical spinal cord injury (SCI) is associated with several critical clinical conditions related to impaired cerebrovascular health, including: 300-400% increased risk of stroke, cognitive decline and diminished cerebral blood flow regulation. The purpose of this study was to examine the influence of high-thoracic (T3 spinal segment) SCI on cerebrovascular structure and function, as well as molecular markers of profibrosis. Seven weeks after complete T3 spinal cord transection (T3-SCI, n = 15) or sham injury (Sham, n = 10), rats were sacrificed for either middle cerebral artery (MCA) structure and function assessments via ex vivo pressure myography, or immunohistochemical analyses. Myogenic tone was unchanged, but over a range of transmural pressures, inward remodelling occurred after T3-SCI with a 40% reduction in distensibility (both P < 0.05), and a 33% reduction in vasoconstrictive reactivity to 5-HT trending toward significance (P = 0.09). After T3-SCI, the MCA had more collagen I (42%), collagen III (24%), transforming growth factor β (47%) and angiotensin II receptor type 2 (132%), 27% less elastin as well as concurrent increased wall thickness and reduced lumen diameter (all P < 0.05). Sympathetic innervation (tyrosine hydroxylase-positive axon density) and endothelium-dependent dilatation (carbachol) of the MCA were not different between groups. This study demonstrates profibrosis and hypertrophic inward remodelling within the largest cerebral artery after high-thoracic SCI, leading to increased stiffness and possibly impaired reactivity. These deleterious adaptations would substantially undermine the capacity for regulation of cerebral blood flow and probably underlie several cerebrovascular clinical conditions in the SCI population.

  15. The smallest chemical reaction system with bistability

    PubMed Central

    Wilhelm, Thomas

    2009-01-01

    Background Bistability underlies basic biological phenomena, such as cell division, differentiation, cancer onset, and apoptosis. So far biologists identified two necessary conditions for bistability: positive feedback and ultrasensitivity. Results Biological systems are based upon elementary mono- and bimolecular chemical reactions. In order to definitely clarify all necessary conditions for bistability we here present the corresponding minimal system. According to our definition, it contains the minimal number of (i) reactants, (ii) reactions, and (iii) terms in the corresponding ordinary differential equations (decreasing importance from i-iii). The minimal bistable system contains two reactants and four irreversible reactions (three bimolecular, one monomolecular). We discuss the roles of the reactions with respect to the necessary conditions for bistability: two reactions comprise the positive feedback loop, a third reaction filters out small stimuli thus enabling a stable 'off' state, and the fourth reaction prevents explosions. We argue that prevention of explosion is a third general necessary condition for bistability, which is so far lacking discussion in the literature. Moreover, in addition to proving that in two-component systems three steady states are necessary for bistability (five for tristability, etc.), we also present a simple general method to design such systems: one just needs one production and three different degradation mechanisms (one production, five degradations for tristability, etc.). This helps modelling multistable systems and it is important for corresponding synthetic biology projects. Conclusion The presented minimal bistable system finally clarifies the often discussed question for the necessary conditions for bistability. The three necessary conditions are: positive feedback, a mechanism to filter out small stimuli and a mechanism to prevent explosions. This is important for modelling bistability with simple systems and for

  16. A novel bistable energy harvesting concept

    NASA Astrophysics Data System (ADS)

    Scarselli, G.; Nicassio, F.; Pinto, F.; Ciampa, F.; Iervolino, O.; Meo, M.

    2016-05-01

    Bistable energy harvesting has become a major field of research due to some unique features for converting mechanical energy into electrical power. When properly loaded, bistable structures snap-through from one stable configuration to another, causing large strains and consequently power generation. Moreover, bistable structures can harvest energy across a broad-frequency bandwidth due to their nonlinear characteristics. Despite the fact that snap-through may be triggered regardless of the form or frequency of exciting vibration, the external force must reach a specific snap-through activation threshold value to trigger the transition from one stable state to another. This aspect is a limiting factor for realistic vibration energy harvesting application with bistable devices. This paper presents a novel power harvesting concept for bistable composites based on a ‘lever effect’ aimed at minimising the activation force to cause the snap through by choosing properly the bistable structures’ constraints. The concept was demonstrated with the help of numerical simulation and experimental testing. The results showed that the actuation force is one order of magnitude smaller (3%-6%) than the activation force of conventionally constrained bistable devices. In addition, it was shown that the output voltage was higher than the conventional configuration, leading to a significant increase in power generation. This novel concept could lead to a new generation of more efficient bistable energy harvesters for realistic vibration environments.

  17. Bistable solutions for the electron energy distribution function in electron swarms in xenon: a comparison between the results of first-principles particle simulations and conventional Boltzmann equation analysis

    NASA Astrophysics Data System (ADS)

    Dyatko, Nikolay; Donkó, Zoltán

    2015-08-01

    At low reduced electric fields the electron energy distribution function in heavy noble gases can take two distinct shapes. This ‘bistability effect’—in which electron-electron (Coulomb) collisions play an essential role—is analyzed here for Xe with a Boltzmann equation approach and with a first principles particle simulation method. The solution of the Boltzmann equation adopts the usual approximations of (i) searching for the distribution function in the form of two terms (‘two-term approximation’), (ii) neglecting the Coulomb part of the collision integral for the anisotropic part of the distribution function, (iii) treating Coulomb collisions as binary events, and (iv) truncating the range of the electron-electron interaction beyond a characteristic distance. The particle-based simulation method avoids these approximations: the many-body interactions within the electron gas with a true (un-truncated) Coulomb potential are described by a molecular dynamics algorithm, while the collisions between electrons and the background gas atoms are treated with Monte Carlo simulation. We find a good general agreement between the results of the two techniques, which confirms, to a certain extent, the approximations used in the solution of the Boltzmann equation. The differences observed between the results are believed to originate from these approximations and from the presence of statistical noise in the particle simulations.

  18. Bistable electroactive polymer for refreshable Braille display with improved actuation stability

    NASA Astrophysics Data System (ADS)

    Niu, Xiaofan; Brochu, Paul; Stoyanov, Hristiyan; Yun, Sung Ryul; Pei, Qibing

    2012-04-01

    Poly(t-butyl acrylate) is a bistable electroactive polymer (BSEP) capable of rigid-to-rigid actuation. The BSEP combines the large-strain actuation of dielectric elastomers with shape memory property. We have introduced a material approach to overcome pull-in instability in poly(t-butyl acrylate) that significantly improves the actuation lifetime at strains greater than 100%. Refreshable Braille display devices with size of a smartphone screen have been fabricated to manifest a potential application of the BSEP. We will report the testing results of the devices by a Braille user.

  19. Mm-size bistable zipping dielectric elastomer actuators for integrated microfluidics

    NASA Astrophysics Data System (ADS)

    Maffli, Luc; Rosset, Samuel; Shea, Herbert R.

    2013-04-01

    We report on a new structure of Dielectric Elastomer Actuators (DEAs) called zipping DEAs, which have a set of unique characteristics that are a good match for the requirements of electrically-powered integrated microfluidic pumping and/or valving units as well as Braille displays. The zipping DEAs operate by pulling electrostatically an elastomer membrane in contact with the rigid sidewalls of a sloped chamber. In this work, we report on fully functional mm-size zipping DEAs that demonstrate a complete sealing of the chamber sidewalls and a tunable bistable behavior, and compare the measurements with an analytical model. Compared to our first generation of devices, we are able vary the sidewall angle and benefit therefore from more flexibility to study the requirements to make fully functional actuators. In particular, we show that with Nusil CF19 as membrane material (1.2 MPa Young's modulus), it is possible to zip completely 2.3 mm diameter chambers with 15° and 21° sidewalls angle equibiaxially prestretched to λ0=1.12 and 15° chambers with λ0=1.27.

  20. Evidence for distinct mechanisms underlying attentional priming and sensory memory for bistable perception.

    PubMed

    Brinkhuis, M A B; Kristjánsson, Á; Brascamp, J W

    2015-08-01

    Attentional selection in visual search paradigms and perceptual selection in bistable perception paradigms show functional similarities. For example, both are sensitive to trial history: They are biased toward previously selected targets or interpretations. We investigated whether priming by target selection in visual search and sensory memory for bistable perception are related. We did this by presenting two trial types to observers. We presented either ambiguous spheres that rotated over a central axis and could be perceived as rotating in one of two directions, or search displays in which the unambiguously rotating target and distractor spheres closely resembled the two possible interpretations of the ambiguous stimulus. We interleaved both trial types within experiments, to see whether priming by target selection during search trials would affect the perceptual outcome of bistable perception and, conversely, whether sensory memory during bistable perception would affect target selection times during search. Whereas we found intertrial repetition effects among consecutive search trials and among consecutive bistable trials, we did not find cross-paradigm effects. Thus, even though we could ascertain that our experiments robustly elicited processes of both search priming and sensory memory for bistable perception, these same experiments revealed no interaction between the two.

  1. Tunable bistable devices for harvesting energy from spinning wheels

    NASA Astrophysics Data System (ADS)

    Elhadidi, Mohamed; Helal, Mohammed; Nassar, Omar; Arafa, Mustafa; Zeyada, Yasser

    2015-04-01

    Bistable systems have recently been employed for vibration energy harvesting owing to their favorable dynamic characteristics and desirable response for wideband excitation. In this paper, we investigate the use of bistable harvesters to extract energy from spinning wheels. The proposed harvester consists of a piezoelectric cantilever beam that is mounted on a rigid spinning hub and carries a tip mass in the form of a permanent magnet. Magnetic repulsion forces from an opposite magnet cause the beam to possess two stable equilibrium positions. Inter-well lead-lag oscillations caused by rotation in a vertical plane provide a good source for energy extraction. The design offers frequency tuning, as the centrifugal forces strain the harvester, thereby increasing its natural frequency to cope with a variable rotational speed. This has applications in self-powered sensors mounted on spinning wheels, such as tire pressure monitoring sensors. An effort is made to select the design parameters to enable the harvester to exhibit favorable inter-well oscillations across a range of rotational speeds for enhanced energy harvesting. Findings of the present work are verified both numerically and experimentally.

  2. Exploring Neuronal Bistability at the Depolarization Block

    PubMed Central

    Dovzhenok, Andrey; Kuznetsov, Alexey S.

    2012-01-01

    Many neurons display bistability–coexistence of two firing modes such as bursting and tonic spiking or tonic spiking and silence. Bistability has been proposed to endow neurons with richer forms of information processing in general and to be involved in short-term memory in particular by allowing a brief signal to elicit long-lasting changes in firing. In this paper, we focus on bistability that allows for a choice between tonic spiking and depolarization block in a wide range of the depolarization levels. We consider the spike-producing currents in two neurons, models of which differ by the parameter values. Our dopaminergic neuron model displays bistability in a wide range of applied currents at the depolarization block. The Hodgkin-Huxley model of the squid giant axon shows no bistability. We varied parameter values for the model to analyze transitions between the two parameter sets. We show that bistability primarily characterizes the inactivation of the Na+ current. Our study suggests a connection between the amount of the Na+ window current and the length of the bistability range. For the dopaminergic neuron we hypothesize that bistability can be linked to a prolonged action of antipsychotic drugs. PMID:22900051

  3. Fast-switching bistable cholesteric intensity modulator.

    PubMed

    Hsiao, Yu-Cheng; Tang, Chen-Yu; Lee, Wei

    2011-05-01

    A fast-switching bistable optical intensity modulator is demonstrated. Using a dual-frequency cholesteric liquid crystal, the direct switching is achieved from the scattering focal conic state to the transparent long-pitch planar state. In comparison with the bistable cholesteric devices proposed previously, our device, characterized by its capability of direct two-way transitions between the two bistable states, possesses a very short transition time from the focal conic state to the planar state as short as 10 ms. No voltage has to be applied to sustain the optical states, making the device low energy consuming. Potential applications of this device are addressed.

  4. Topology and bistability in liquid crystal devices

    SciTech Connect

    Majumdar, A.; Newton, C. J. P.; Robbins, J. M.; Zyskin, M.

    2007-05-15

    We study nematic liquid crystal configurations in a prototype bistable device--the post aligned bistable nematic (PABN) cell. Working within the Oseen-Frank continuum model, we describe the liquid crystal configuration by a unit-vector field n, in a model version of the PABN cell. First, we identify four distinct topologies in this geometry. We explicitly construct trial configurations with these topologies which are used as initial conditions for a numerical solver, based on the finite-element method. The morphologies and energetics of the corresponding numerical solutions qualitatively agree with experimental observations and suggest a topological mechanism for bistability in the PABN cell geometry.

  5. Fast-switching bistable cholesteric intensity modulator.

    PubMed

    Hsiao, Yu-Cheng; Tang, Chen-Yu; Lee, Wei

    2011-05-01

    A fast-switching bistable optical intensity modulator is demonstrated. Using a dual-frequency cholesteric liquid crystal, the direct switching is achieved from the scattering focal conic state to the transparent long-pitch planar state. In comparison with the bistable cholesteric devices proposed previously, our device, characterized by its capability of direct two-way transitions between the two bistable states, possesses a very short transition time from the focal conic state to the planar state as short as 10 ms. No voltage has to be applied to sustain the optical states, making the device low energy consuming. Potential applications of this device are addressed. PMID:21643231

  6. MAPK Signaling and ERK1/2 bistability in Asthma

    PubMed Central

    Alam, Rafeul; Gorska, Magdalena M.

    2010-01-01

    Mitogen-activated protein kinases (MAPK) integrate signals from numerous receptors and translate these signals into cell functions. MAPKs are critical for immune cell metabolism, migration, production of pro-inflammatory mediators, survival, and differentiation. We provide a concise review of the involvement of MAPK in important cells of the immune system. Certain cell functions e.g. production of pro-inflammatory mediators resolve quickly and may require a transient MAPK activation, other processes such as cell differentiation and long-term survival may require persistent MAPK signal. The persistent MAPK signal is frequently a consequence of positive feedback loops or double negative feedback loops which perpetuate the signal after removal of an external cell stimulus. This self-perpetuated activation of a signaling circuit is a manifestation of its bistability. Bistable systems can exist in “on” and “off” states and both states are stable. We have demonstrated the existence of self-perpetuated activation mechanism for ERK1/2 in bronchial epithelial cells. This sustained activation of ERK1/2 supports long-term survival of these cells and primes them for cytokine transcription. ERK1/2 bistability arises from repetitive stimulation of the cell. The repeated stimulation (e.g. repeated viral infection or repeated allergen exposure) seems to be a common theme in asthma and other chronic illnesses. We thus hypothesize that the self-perpetuated ERK1/2 signal plays an important role in the pathogenesis of asthma. PMID:21121982

  7. Bistability and chaos at low levels of quanta

    NASA Astrophysics Data System (ADS)

    Gevorgyan, T. V.; Shahinyan, A. R.; Chew, Lock Yue; Kryuchkyan, G. Yu.

    2013-08-01

    We study nonlinear phenomena of bistability and chaos at a level of few quanta. For this purpose, we consider a single-mode dissipative oscillator with strong Kerr nonlinearity with respect to the dissipation rate driven by a monochromatic force as well as by a train of Gaussian pulses. The quantum effects and decoherence in the oscillatory mode are investigated in the framework of the purity of states and the Wigner functions calculated from the master equation. We demonstrate the quantum chaotic regime by means of a comparison between the contour plots of the Wigner functions and the strange attractors on the classical Poincaré section. Considering bistability at a low limit of quanta, we analyze the minimal level of excitation numbers at which the bistable regime of the system is displayed. We also discuss the formation of an oscillatory chaotic regime by varying oscillatory excitation numbers at ranges of a few quanta. We demonstrate quantum-interference phenomena that are assisted hysteresis-cycle behavior and quantum chaos for the oscillator driven by a train of Gaussian pulses. We establish the border of quantum-classical correspondence for chaotic regimes in the case of strong nonlinearities.

  8. Bistable diverter valve in microfluidics

    NASA Astrophysics Data System (ADS)

    Tesař, V.; Bandalusena, H. C. H.

    2011-05-01

    Bistable diverter valves are useful for a large number of no-moving-part flow control applications, and there is a considerable interest in using them also in microfluidics, especially for handling small pressure-driven flows. However, with decreasing Reynolds number, the Coanda effect—on which the flow diverting effect depends—becomes less effective. Authors performed a study, involving flow visualisation, PIV experiments, measurements of the flow rates, and numerical flowfield computations, aimed at clarifying behaviour of a typical fluidic valve at low Reynolds numbers. A typical fluidic valve originally developed for high Re operation was demonstrated to be useful, though with progressively limited efficiency, down to surprisingly low Re values as small as Re = 800. Also observed was a previously not reported discontinuation in the otherwise monotonic decrease in performance at Re between 1,500 and 2,000.

  9. Analysis on optical bistability parameters in photonic switching devices

    NASA Astrophysics Data System (ADS)

    Sarafraz, Hossein; Sayeh, Mohammad R.

    2016-06-01

    An investigation has been done on the parameters of a hysteretic bistable optical Schmitt trigger device. From a design point of view, it is important to know the regions where this bistability occurs and is fully functional with respect to its subsystem parameters. Otherwise experimentally reaching such behavior will be very time-consuming and frustrating, especially with multiple devices employed in a single photonic circuit. A photonic Schmitt trigger consisting of two feedbacked inverting amplifiers, each characterized by -m (slope), A (y-intercept), and B (constant base) parameters is considered. This system is investigated dynamically with a varying input to find its stable and unstable states both mathematically and with simulation. In addition to a complete mathematical analysis of the system, we also describe how m, A, and B can be properly chosen in order to satisfy certain system conditions that result in bistability. More restrictions are also imposed to these absolute conditions by the system conditions as will be discussed. Finally, all results are verified in a more realistic photonic simulation.

  10. GABA shapes the dynamics of bistable perception.

    PubMed

    van Loon, Anouk M; Knapen, Tomas; Scholte, H Steven; St John-Saaltink, Elexa; Donner, Tobias H; Lamme, Victor A F

    2013-05-01

    Sometimes, perception fluctuates spontaneously between two distinct interpretations of a constant sensory input. These bistable perceptual phenomena provide a unique window into the neural mechanisms that create the contents of conscious perception. Models of bistable perception posit that mutual inhibition between stimulus-selective neural populations in visual cortex plays a key role in these spontaneous perceptual fluctuations. However, a direct link between neural inhibition and bistable perception has not yet been established experimentally. Here, we link perceptual dynamics in three distinct bistable visual illusions (binocular rivalry, motion-induced blindness, and structure from motion) to measurements of gamma-aminobutyric acid (GABA) concentrations in human visual cortex (as measured with magnetic resonance spectroscopy) and to pharmacological stimulation of the GABAA receptor by means of lorazepam. As predicted by a model of neural interactions underlying bistability, both higher GABA concentrations in visual cortex and lorazepam administration induced slower perceptual dynamics, as reflected in a reduced number of perceptual switches and a lengthening of percept durations. Thus, we show that GABA, the main inhibitory neurotransmitter, shapes the dynamics of bistable perception. These results pave the way for future studies into the competitive neural interactions across the visual cortical hierarchy that elicit conscious perception. PMID:23602476

  11. Nonlinear time-varying potential bistable energy harvesting from human motion

    NASA Astrophysics Data System (ADS)

    Cao, Junyi; Wang, Wei; Zhou, Shengxi; Inman, Daniel J.; Lin, Jing

    2015-10-01

    A theoretical and experimental investigation into nonlinear bistable energy harvesting with time-varying potential energy is presented. The motivation for examining time-varying potentials comes from the desire to harvest energy from human motion. Time-varying potential energy function of bistable oscillator with respect to the swing angle are established to derive the governing electromechanical model for harvesting vibration energy from the swaying motion during human walking or running. Numerical simulations show good agreement with the experimental potential energy function under different swing angles. Various motion speed treadmill tests are performed to demonstrate the advantage of time-varying bistable harvesters over linear and monostable ones in harvesting energy from human motion.

  12. Origin of bistability in the lac Operon.

    PubMed

    Santillán, M; Mackey, M C; Zeron, E S

    2007-06-01

    Multistability is an emergent dynamic property that has been invoked to explain multiple coexisting biological states. In this work, we investigate the origin of bistability in the lac operon. To do this, we develop a mathematical model for the regulatory pathway in this system and compare the model predictions with other experimental results in which a nonmetabolizable inducer was employed. We investigate the effect of lactose metabolism using this model, and show that it greatly modifies the bistable region in the external lactose (Le) versus external glucose (Ge) parameter space. The model also predicts that lactose metabolism can cause bistability to disappear for very low Ge. We have also carried out stochastic numerical simulations of the model for several values of Ge and Le. Our results indicate that bistability can help guarantee that Escherichia coli consumes glucose and lactose in the most efficient possible way. Namely, the lac operon is induced only when there is almost no glucose in the growing medium, but if Le is high, the operon induction level increases abruptly when the levels of glucose in the environment decrease to very low values. We demonstrate that this behavior could not be obtained without bistability if the stability of the induced and uninduced states is to be preserved. Finally, we point out that the present methods and results may be useful to study the emergence of multistability in biological systems other than the lac operon. PMID:17351004

  13. Hybrid optoelectronic device with multiple bistable outputs

    NASA Astrophysics Data System (ADS)

    Costazo-Caso, Pablo A.; Jin, Yiye; Gelh, Michael; Granieri, Sergio; Siahmakoun, Azad

    2011-01-01

    Optoelectronic circuits which exhibit optical and electrical bistability with hysteresis behavior are proposed and experimentally demonstrated. The systems are based on semiconductor optical amplifiers (SOA), bipolar junction transistors (BJT), PIN photodiodes (PD) and laser diodes externally modulated with integrated electro-absorption modulators (LD-EAM). The device operates based on two independent phenomena leading to both electrical bistability and optical bistability. The electrical bistability is due to the series connection of two p-i-n structures (SOA, BJT, PD or LD) in reverse bias. The optical bistability is consequence of the quantum confined Stark effect (QCSE) in the multi-quantum well (MQW) structure in the intrinsic region of the device. This effect produces the optical modulation of the transmitted light through the SOA (or reflected from the PD). Finally, because the optical transmission of the SOA (in reverse bias) and the reflected light from the PD are so small, a LD-EAM modulated by the voltage across these devices are employed to obtain a higher output optical power. Experiments show that the maximum switching frequency is in MHz range and the rise/fall times lower than 1 us. The temporal response is mainly limited by the electrical capacitance of the devices and the parasitic inductances of the connecting wires. The effects of these components can be reduced in current integration technologies.

  14. Bistable dielectric elastomer minimum energy structures

    NASA Astrophysics Data System (ADS)

    Zhao, Jianwen; Wang, Shu; McCoul, David; Xing, Zhiguang; Huang, Bo; Liu, Liwu; Leng, Jinsong

    2016-07-01

    Dielectric elastomer minimum energy structures (DEMES) can realize large angular deformations by small voltage-induced strains, which make them an attractive candidate for use as soft actuators. If the task only needs binary action, the bistable structure will be an efficient solution and can save energy because it requires only a very short duration of voltage to switch its state. To obtain bistable DEMES, a method to realize the two stable states of traditional DEMES is provided in this paper. Based on this, a type of symmetrical bistable DEMES is proposed, and the required actuation pulse duration is shorter than 0.1 s. When a suitable mass is attached to end of the DEMES, or two layers of dielectric elastomer are affixed to both sides of the primary frame, the DEMES can realize two stable states and can be switched by a suitable pulse duration. To calculate the required minimum pulse duration, a mathematical model is provided and validated by experiment.

  15. Designing rigid carbon foams.

    PubMed

    Park, Sora; Kittimanapun, Kritsada; Ahn, Jeung Sun; Kwon, Young-Kyun; Tománek, David

    2010-08-25

    We use ab initio density functional calculations to study the stability, elastic properties and electronic structure of sp(2) carbon minimal surfaces with negative Gaussian curvature, called schwarzites. We focus on two systems with cubic unit cells containing 152 and 200 carbon atoms, which are metallic and very rigid. The porous schwarzite structure allows for efficient and reversible doping by electron donors and acceptors, making it a promising candidate for the next generation of alkali ion batteries. We identify schwarzite structures that act as arrays of interconnected spin quantum dots or become magnetic when doped. We introduce two interpenetrating schwarzite structures that may find their use as the ultimate super-capacitor.

  16. Bi-stable energy harvesting based on a simply supported piezoelectric buckled beam

    NASA Astrophysics Data System (ADS)

    Xu, Chundong; Liang, Zhu; Ren, Bo; Di, Wenning; Luo, Haosu; Wang, Dong; Wang, Kailing; Chen, Zhifang

    2013-09-01

    Bi-stable piezoelectric energy harvester has been found as a promising structure for vibration energy harvesting. This paper presents a high performance and simple structure bi-stable piezoelectric energy harvester based on simply supported piezoelectric buckled beam. The potential energy function is established theoretically, and electrical properties of the device under different axial compressive displacements, excitation frequencies, and accelerations are investigated systematically. Experimental results demonstrate that the output properties and bandwidth of the bi-stable nonlinear energy harvester under harmonic mechanical excitation are improved dramatically compared with the traditional linear energy harvester. The device demonstrates the potential in energy harvesting application to low-power portable electronics and wireless sensor nodes.

  17. Neuromechanistic Model of Auditory Bistability

    PubMed Central

    Rankin, James; Sussman, Elyse; Rinzel, John

    2015-01-01

    Sequences of higher frequency A and lower frequency B tones repeating in an ABA- triplet pattern are widely used to study auditory streaming. One may experience either an integrated percept, a single ABA-ABA- stream, or a segregated percept, separate but simultaneous streams A-A-A-A- and -B---B--. During minutes-long presentations, subjects may report irregular alternations between these interpretations. We combine neuromechanistic modeling and psychoacoustic experiments to study these persistent alternations and to characterize the effects of manipulating stimulus parameters. Unlike many phenomenological models with abstract, percept-specific competition and fixed inputs, our network model comprises neuronal units with sensory feature dependent inputs that mimic the pulsatile-like A1 responses to tones in the ABA- triplets. It embodies a neuronal computation for percept competition thought to occur beyond primary auditory cortex (A1). Mutual inhibition, adaptation and noise are implemented. We include slow NDMA recurrent excitation for local temporal memory that enables linkage across sound gaps from one triplet to the next. Percepts in our model are identified in the firing patterns of the neuronal units. We predict with the model that manipulations of the frequency difference between tones A and B should affect the dominance durations of the stronger percept, the one dominant a larger fraction of time, more than those of the weaker percept—a property that has been previously established and generalized across several visual bistable paradigms. We confirm the qualitative prediction with our psychoacoustic experiments and use the behavioral data to further constrain and improve the model, achieving quantitative agreement between experimental and modeling results. Our work and model provide a platform that can be extended to consider other stimulus conditions, including the effects of context and volition. PMID:26562507

  18. Unidirectional Transition Waves in Bistable Lattices

    NASA Astrophysics Data System (ADS)

    Nadkarni, Neel; Arrieta, Andres F.; Chong, Christopher; Kochmann, Dennis M.; Daraio, Chiara

    2016-06-01

    We present a model system for strongly nonlinear transition waves generated in a periodic lattice of bistable members connected by magnetic links. The asymmetry of the on-site energy wells created by the bistable members produces a mechanical diode that supports only unidirectional transition wave propagation with constant wave velocity. We theoretically justify the cause of the unidirectionality of the transition wave and confirm these predictions by experiments and simulations. We further identify how the wave velocity and profile are uniquely linked to the double-well energy landscape, which serves as a blueprint for transition wave control.

  19. THE DENSITY DISTRIBUTION IN TURBULENT BISTABLE FLOWS

    SciTech Connect

    Gazol, Adriana; Kim, Jongsoo E-mail: jskim@kasi.re.kr

    2013-03-01

    We numerically study the volume density probability distribution function (n-PDF) and the column density probability distribution function ({Sigma}-PDF) resulting from thermally bistable turbulent flows. We analyze three-dimensional hydrodynamic models in periodic boxes of 100 pc by side, where turbulence is driven in the Fourier space at a wavenumber corresponding to 50 pc. At low densities (n {approx}< 0.6 cm{sup -3}), the n-PDF is well described by a lognormal distribution for an average local Mach number ranging from {approx}0.2 to {approx}5.5. As a consequence of the nonlinear development of thermal instability (TI), the logarithmic variance of the distribution of the diffuse gas increases with M faster than in the well-known isothermal case. The average local Mach number for the dense gas (n {approx}> 7.1 cm{sup -3}) goes from {approx}1.1 to {approx}16.9 and the shape of the high-density zone of the n-PDF changes from a power law at low Mach numbers to a lognormal at high M values. In the latter case, the width of the distribution is smaller than in the isothermal case and grows slower with M. At high column densities, the {Sigma}-PDF is well described by a lognormal for all of the Mach numbers we consider and, due to the presence of TI, the width of the distribution is systematically larger than in the isothermal case but follows a qualitatively similar behavior as M increases. Although a relationship between the width of the distribution and M can be found for each one of the cases mentioned above, these relations are different from those of the isothermal case.

  20. Rigid particulate matter sensor

    DOEpatents

    Hall, Matthew

    2011-02-22

    A sensor to detect particulate matter. The sensor includes a first rigid tube, a second rigid tube, a detection surface electrode, and a bias surface electrode. The second rigid tube is mounted substantially parallel to the first rigid tube. The detection surface electrode is disposed on an outer surface of the first rigid tube. The detection surface electrode is disposed to face the second rigid tube. The bias surface electrode is disposed on an outer surface of the second rigid tube. The bias surface electrode is disposed to face the detection surface electrode on the first rigid tube. An air gap exists between the detection surface electrode and the bias surface electrode to allow particulate matter within an exhaust stream to flow between the detection and bias surface electrodes.

  1. Representation of solutions to the problem of the motion of a heavy rigid body in the Kovalevskaya case in terms of Weierstrass \\zeta- and \\wp-functions and nonintegrability of the Hess case by quadratures

    NASA Astrophysics Data System (ADS)

    Belyaev, A. V.

    2016-07-01

    A method for the representation of Delaunay's solutions and some other particular solutions to the problem of the motion of a heavy rigid body in the Kovalevskaya case in terms of the Weierstrass \\zeta- and \\wp-functions is put forward. The Hess case in the problem of the motion of a heavy rigid body is shown to be nonintegrable by quadratures. Bibliography: 24 titles.

  2. A bistable model of cell polarity.

    PubMed

    Semplice, Matteo; Veglio, Andrea; Naldi, Giovanni; Serini, Guido; Gamba, Andrea

    2012-01-01

    Ultrasensitivity, as described by Goldbeter and Koshland, has been considered for a long time as a way to realize bistable switches in biological systems. It is not as well recognized that when ultrasensitivity and reinforcing feedback loops are present in a spatially distributed system such as the cell plasmamembrane, they may induce bistability and spatial separation of the system into distinct signaling phases. Here we suggest that bistability of ultrasensitive signaling pathways in a diffusive environment provides a basic mechanism to realize cell membrane polarity. Cell membrane polarization is a fundamental process implicated in several basic biological phenomena, such as differentiation, proliferation, migration and morphogenesis of unicellular and multicellular organisms. We describe a simple, solvable model of cell membrane polarization based on the coupling of membrane diffusion with bistable enzymatic dynamics. The model can reproduce a broad range of symmetry-breaking events, such as those observed in eukaryotic directional sensing, the apico-basal polarization of epithelium cells, the polarization of budding and mating yeast, and the formation of Ras nanoclusters in several cell types.

  3. Organic bistable light-emitting devices

    NASA Astrophysics Data System (ADS)

    Ma, Liping; Liu, Jie; Pyo, Seungmoon; Yang, Yang

    2002-01-01

    An organic bistable device, with a unique trilayer structure consisting of organic/metal/organic sandwiched between two outmost metal electrodes, has been invented. [Y. Yang, L. P. Ma, and J. Liu, U.S. Patent Pending, U.S. 01/17206 (2001)]. When the device is biased with voltages beyond a critical value (for example 3 V), the device suddenly switches from a high-impedance state to a low-impedance state, with a difference in injection current of more than 6 orders of magnitude. When the device is switched to the low-impedance state, it remains in that state even when the power is off. (This is called "nonvolatile" phenomenon in memory devices.) The high-impedance state can be recovered by applying a reverse bias; therefore, this bistable device is ideal for memory applications. In order to increase the data read-out rate of this type of memory device, a regular polymer light-emitting diode has been integrated with the organic bistable device, such that it can be read out optically. These features make the organic bistable light-emitting device a promising candidate for several applications, such as digital memories, opto-electronic books, and recordable papers.

  4. Asymptotic iteration approach to supersymmetric bistable potentials

    NASA Astrophysics Data System (ADS)

    Ciftci, H.; Özer, O.; P., Roy

    2012-01-01

    We examine quasi exactly solvable bistable potentials and their supersymmetric partners within the framework of the asymptotic iteration method (AIM). It is shown that the AIM produces excellent approximate spectra and that sometimes it is found to be more useful to use the partner potential for computation. We also discuss the direct application of the AIM to the Fokker—Planck equation.

  5. Bistability and hysteresis of annular impinging jets

    NASA Astrophysics Data System (ADS)

    Tisovsky, Tomas

    2016-06-01

    In present study, the bistability and hysteresis of annular impinging jets is investigated. Annular impinging jets are simulated using open source CFD code - OpenFOAM. Both flow field patterns of interest are obtained and hysteresis is found by means of dynamic mesh simulation. Effect of nozzle exit velocity on resulting hysteresis loop is also illustrated.

  6. Designing light responsive bistable arches for rapid, remotely triggered actuation

    NASA Astrophysics Data System (ADS)

    Smith, Matthew L.; Shankar, M. Ravi; Backman, Ryan; Tondiglia, Vincent P.; Lee, Kyung Min; McConney, Michael E.; Wang, David H.; Tan, Loon-Seng; White, Timothy J.

    2014-03-01

    Light responsive azobenzene functionalized polymer networks enjoy several advantages as actuator candidates including the ability to be remotely triggered and the capacity for highly tunable control via light intensity, polarization, wavelength and material alignments. One signi cant challenge hindering these materials from being employed in applications is their often relatively slow actuation rates and low power densities, especially in the absence of photo-thermal e ects. One well known strategy employed in nature for increasing actuation rate and power output is the storage and quick release of elastic energy (e.g., the Venus ytrap). Using nature as inspiration we have conducted a series of experiments and developed an equilibrium mechanics model for investigating remotely triggered snap-through of bistable light responsive arches made from glassy azobenzene functionalized polymers. After brie y discussing experimental observations we consider in detail a geometrically exact, planar rod model of photomechanical snap-through. Theoretical energy release characteristics and unique strain eld pro les provide insight toward design strategies for improved actuator performance. The bistable light responsive arches presented here are potentially a powerful option for remotely triggered, rapid motion from apparently passive structures in applications such as binary optical switches and positioners, surfaces with morphing topologies, and impulse locomotion in micro or millimeter scale robotics.

  7. The Bistable Potential:. AN Archetype for Classical and Quantum Systems

    NASA Astrophysics Data System (ADS)

    Spagnolo, B.; Caldara, P.; La Cognata, A.; Valenti, D.; Fiasconaro, A.; Dubkov, A. A.; Falci, G.

    In this work we analyze the transient dynamics of three different classical and quantum systems. First, we consider a classical Brownian particle moving in an asymmetric bistable potential, subject to a multiplicative and additive noise source. We investigate the role of these two noise sources on the life time of the metastable state. A nonmonotonic behavior of the lifetime as a function of both additive and multiplicative noise intensities is found, revealing the phenomenon of noise enhanced stability. Afterward, by using a Lotka-Volterra model, the dynamics of two competing species in the presence of Lévy noise sources is analyzed. Quasiperiodic oscillations and stochastic resonance phenomenon in the dynamics of the competing species are found. Finally the dynamics of a quantum particle subject to an asymmetric bistable potential and interacting with a thermal reservoir is investigated. We use the Caldeira-Leggett model and the approach of the Feynman-Vernon functional in discrete variable representation. We obtain the time evolution of the population distributions in energy eigenstates of the particle, for different values of the coupling strength with the thermal bath.

  8. An analytical approach to bistable biological circuit discrimination using real algebraic geometry

    PubMed Central

    Siegal-Gaskins, Dan; Franco, Elisa; Zhou, Tiffany; Murray, Richard M.

    2015-01-01

    Biomolecular circuits with two distinct and stable steady states have been identified as essential components in a wide range of biological networks, with a variety of mechanisms and topologies giving rise to their important bistable property. Understanding the differences between circuit implementations is an important question, particularly for the synthetic biologist faced with determining which bistable circuit design out of many is best for their specific application. In this work we explore the applicability of Sturm's theorem—a tool from nineteenth-century real algebraic geometry—to comparing ‘functionally equivalent’ bistable circuits without the need for numerical simulation. We first consider two genetic toggle variants and two different positive feedback circuits, and show how specific topological properties present in each type of circuit can serve to increase the size of the regions of parameter space in which they function as switches. We then demonstrate that a single competitive monomeric activator added to a purely monomeric (and otherwise monostable) mutual repressor circuit is sufficient for bistability. Finally, we compare our approach with the Routh–Hurwitz method and derive consistent, yet more powerful, parametric conditions. The predictive power and ease of use of Sturm's theorem demonstrated in this work suggest that algebraic geometric techniques may be underused in biomolecular circuit analysis. PMID:26109633

  9. An analytical approach to bistable biological circuit discrimination using real algebraic geometry.

    PubMed

    Siegal-Gaskins, Dan; Franco, Elisa; Zhou, Tiffany; Murray, Richard M

    2015-07-01

    Biomolecular circuits with two distinct and stable steady states have been identified as essential components in a wide range of biological networks, with a variety of mechanisms and topologies giving rise to their important bistable property. Understanding the differences between circuit implementations is an important question, particularly for the synthetic biologist faced with determining which bistable circuit design out of many is best for their specific application. In this work we explore the applicability of Sturm's theorem--a tool from nineteenth-century real algebraic geometry--to comparing 'functionally equivalent' bistable circuits without the need for numerical simulation. We first consider two genetic toggle variants and two different positive feedback circuits, and show how specific topological properties present in each type of circuit can serve to increase the size of the regions of parameter space in which they function as switches. We then demonstrate that a single competitive monomeric activator added to a purely monomeric (and otherwise monostable) mutual repressor circuit is sufficient for bistability. Finally, we compare our approach with the Routh-Hurwitz method and derive consistent, yet more powerful, parametric conditions. The predictive power and ease of use of Sturm's theorem demonstrated in this work suggest that algebraic geometric techniques may be underused in biomolecular circuit analysis.

  10. Rigidity and flexibility of biological networks.

    PubMed

    Gáspár, Merse E; Csermely, Peter

    2012-11-01

    The network approach became a widely used tool to understand the behaviour of complex systems in the last decade. We start from a short description of structural rigidity theory. A detailed account on the combinatorial rigidity analysis of protein structures, as well as local flexibility measures of proteins and their applications in explaining allostery and thermostability is given. We also briefly discuss the network aspects of cytoskeletal tensegrity. Finally, we show the importance of the balance between functional flexibility and rigidity in protein-protein interaction, metabolic, gene regulatory and neuronal networks. Our summary raises the possibility that the concepts of flexibility and rigidity can be generalized to all networks. PMID:23165349

  11. Coherent signal amplification in bistable nanomechanical oscillators by stochastic resonance

    NASA Astrophysics Data System (ADS)

    Badzey, Robert L.; Mohanty, Pritiraj

    2005-10-01

    Stochastic resonance is a counterintuitive concept: the addition of noise to a noisy system induces coherent amplification of its response. First suggested as a mechanism for the cyclic recurrence of ice ages, stochastic resonance has been seen in a wide variety of macroscopic physical systems: bistable ring lasers, superconducting quantum interference devices (SQUIDs), magnetoelastic ribbons and neurophysiological systems such as the receptors in crickets and crayfish. Although fundamentally important as a mechanism of coherent signal amplification, stochastic resonance has yet to be observed in nanoscale systems. Here we report the observation of stochastic resonance in bistable nanomechanical silicon oscillators. Our nanomechanical systems consist of beams that are clamped at each end and driven into transverse oscillation with the use of a radiofrequency source. Modulation of the source induces controllable switching of the beams between two stable, distinct states. We observe that the addition of white noise causes a marked amplification of the signal strength. Stochastic resonance in nanomechanical systems could have a function in the realization of controllable high-speed nanomechanical memory cells, and paves the way for exploring macroscopic quantum coherence and tunnelling.

  12. Designing a stochastic genetic switch by coupling chaos and bistability

    SciTech Connect

    Zhao, Xiang; Ouyang, Qi; Wang, Hongli

    2015-11-15

    In stem cell differentiation, a pluripotent stem cell becomes progressively specialized and generates specific cell types through a series of epigenetic processes. How cells can precisely determine their fate in a fluctuating environment is a currently unsolved problem. In this paper, we suggest an abstract gene regulatory network to describe mathematically the differentiation phenomenon featuring stochasticity, divergent cell fates, and robustness. The network consists of three functional motifs: an upstream chaotic motif, a buffering motif of incoherent feed forward loop capable of generating a pulse, and a downstream motif which is bistable. The dynamic behavior is typically a transient chaos with fractal basin boundaries. The trajectories take transiently chaotic journeys before divergently settling down to the bistable states. The ratio of the probability that the high state is achieved to the probability that the low state is reached can maintain a constant in a population of cells with varied molecular fluctuations. The ratio can be turned up or down when proper parameters are adjusted. The model suggests a possible mechanism for the robustness against fluctuations that is prominently featured in pluripotent cell differentiations and developmental phenomena.

  13. Designing a stochastic genetic switch by coupling chaos and bistability

    NASA Astrophysics Data System (ADS)

    Zhao, Xiang; Ouyang, Qi; Wang, Hongli

    2015-11-01

    In stem cell differentiation, a pluripotent stem cell becomes progressively specialized and generates specific cell types through a series of epigenetic processes. How cells can precisely determine their fate in a fluctuating environment is a currently unsolved problem. In this paper, we suggest an abstract gene regulatory network to describe mathematically the differentiation phenomenon featuring stochasticity, divergent cell fates, and robustness. The network consists of three functional motifs: an upstream chaotic motif, a buffering motif of incoherent feed forward loop capable of generating a pulse, and a downstream motif which is bistable. The dynamic behavior is typically a transient chaos with fractal basin boundaries. The trajectories take transiently chaotic journeys before divergently settling down to the bistable states. The ratio of the probability that the high state is achieved to the probability that the low state is reached can maintain a constant in a population of cells with varied molecular fluctuations. The ratio can be turned up or down when proper parameters are adjusted. The model suggests a possible mechanism for the robustness against fluctuations that is prominently featured in pluripotent cell differentiations and developmental phenomena.

  14. Identification of optimal parameter combinations for the emergence of bistability

    NASA Astrophysics Data System (ADS)

    Májer, Imre; Hajihosseini, Amirhossein; Becskei, Attila

    2015-12-01

    Bistability underlies cellular memory and maintains alternative differentiation states. Bistability can emerge only if its parameter range is either physically realizable or can be enlarged to become realizable. We derived a general rule and showed that the bistable range of a reaction parameter is maximized by a pair of other parameters in any gene regulatory network provided they satisfy a general condition. The resulting analytical expressions revealed whether or not such reaction pairs are present in prototypical positive feedback loops. They are absent from the feedback loop enclosed by protein dimers but present in both the toggle-switch and the feedback circuit inhibited by sequestration. Sequestration can generate bistability even at narrow feedback expression range at which cooperative binding fails to do so, provided inhibition is set to an optimal value. These results help to design bistable circuits and cellular reprogramming and reveal whether bistability is possible in gene networks in the range of realistic parameter values.

  15. Optical bistability in a nonlinear-shell-coated metallic nanoparticle

    PubMed Central

    Chen, Hongli; Zhang, Youming; Zhang, Baile; Gao, Lei

    2016-01-01

    We provide a self-consistent mean field approximation in the framework of Mie scattering theory to study the optical bistability of a metallic nanoparticle coated with a nonlinear shell. We demonstrate that the nanoparticle coated with a weakly nonlinear shell exhibits optical bistability in a broad range of incident optical intensity. This optical bistability critically relies on the geometry of the shell-coated nanoparticle, especially the fractional volume of the metallic core. The incident wavelength can also affect the optical bistability. Through an optimization-like process, we find a design with broader bistable region and lower threshold field by adjusting the size of the nonlinear shell, the fractional volume of the metallic core, and the incident wavelength. These results may find potential applications in optical bistable devices such as all-optical switches, optical transistors and optical memories. PMID:26907967

  16. Bistable perception modeled as competing stochastic integrations at two levels.

    PubMed

    Gigante, Guido; Mattia, Maurizio; Braun, Jochen; Del Giudice, Paolo

    2009-07-01

    We propose a novel explanation for bistable perception, namely, the collective dynamics of multiple neural populations that are individually meta-stable. Distributed representations of sensory input and of perceptual state build gradually through noise-driven transitions in these populations, until the competition between alternative representations is resolved by a threshold mechanism. The perpetual repetition of this collective race to threshold renders perception bistable. This collective dynamics - which is largely uncoupled from the time-scales that govern individual populations or neurons - explains many hitherto puzzling observations about bistable perception: the wide range of mean alternation rates exhibited by bistable phenomena, the consistent variability of successive dominance periods, and the stabilizing effect of past perceptual states. It also predicts a number of previously unsuspected relationships between observable quantities characterizing bistable perception. We conclude that bistable perception reflects the collective nature of neural decision making rather than properties of individual populations or neurons.

  17. Analysis of steady-state characteristics of bistable laser diodes

    SciTech Connect

    Zhong Lichen; Guo Yili

    1987-05-01

    In this paper we analyze the steady-state characteristics of bistable semiconductor laser diode (BILD). A simple model for optical output of BILD is obtained using nonlinear rate equations for electron and photon densities. This model emphasizes the physical mechanisms and parameters responsible for the bistability, gives the state equation and explains the main features of BILD. Bistability with a very large hysteresis in P/sub 0/-P/sub 4/ characteristics is a distinctive feature of BILD.

  18. Bistable defect structures in blue phase devices.

    PubMed

    Tiribocchi, A; Gonnella, G; Marenduzzo, D; Orlandini, E; Salvadore, F

    2011-12-01

    Blue phases are liquid crystals made up by networks of defects, or disclination lines. While existing phase diagrams show a striking variety of competing metastable topologies for these networks, very little is known as to how to kinetically reach a target structure, or how to switch from one to the other, which is of paramount importance for devices. We theoretically identify two confined blue phase I systems in which by applying an appropriate series of electric field it is possible to select one of two bistable defect patterns. Our results may be used to realize new generation and fast switching energy-saving bistable devices in ultrathin surface treated blue phase I wafers. PMID:22182126

  19. Tubulin Bistability and Polymorphic Dynamics of Microtubules

    NASA Astrophysics Data System (ADS)

    Mohrbach, Hervé; Johner, Albert; Kulić, Igor M.

    2010-12-01

    Based on the hypothesis that the GDP-tubulin dimer is a conformationally bistable molecule—rapidly fluctuating between a discrete curved and a straight state—we develop a model for polymorphic dynamics of the microtubule lattice. We show that GDP-tubulin bistability consistently explains unusual dynamic fluctuations, the apparent length-stiffness relation of grafted taxol-stabilized microtubules, and the curved-helical appearance of microtubules in general. When clamped by one end the microtubules undergo an unusual zero energy motion—in its effect reminiscent of a limited rotational hinge. We conclude that microtubules exist in highly cooperative energy-degenerate helical states and discuss possible implications in vivo.

  20. Dynamo efficiency controlled by hydrodynamic bistability.

    PubMed

    Miralles, Sophie; Herault, Johann; Herault, Johann; Fauve, Stephan; Gissinger, Christophe; Pétrélis, François; Daviaud, François; Dubrulle, Bérengère; Boisson, Jean; Bourgoin, Mickaël; Verhille, Gautier; Odier, Philippe; Pinton, Jean-François; Plihon, Nicolas

    2014-06-01

    Hydrodynamic and magnetic behaviors in a modified experimental setup of the von Kármán sodium flow-where one disk has been replaced by a propeller-are investigated. When the rotation frequencies of the disk and the propeller are different, we show that the fully turbulent hydrodynamic flow undergoes a global bifurcation between two configurations. The bistability of these flow configurations is associated with the dynamics of the central shear layer. The bistable flows are shown to have different dynamo efficiencies; thus for a given rotation rate of the soft-iron disk, two distinct magnetic behaviors are observed depending on the flow configuration. The hydrodynamic transition controls the magnetic field behavior, and bifurcations between high and low magnetic field branches are investigated. PMID:25019895

  1. Memory bistable mechanisms of organic memory devices

    NASA Astrophysics Data System (ADS)

    Lee, Ching-Ting; Yu, Li-Zhen; Chen, Hung-Chun

    2010-07-01

    To investigate the memory bistable mechanisms of organic memory devices, the structure of [top Au anode/9,10-di(2-naphthyl)anthracene (ADN) active layer/bottom Au cathode] was deposited using a thermal deposition system. The Au atoms migrated into the ADN active layer was observed from the secondary ion mass spectrometry. The density of 9.6×1016 cm-3 and energy level of 0.553 eV of the induced trapping centers caused by the migrated Au atoms in the ADN active layer were calculated. The induced trapping centers did not influence the carrier injection barrier height between Au and ADN active layer. Therefore, the memory bistable behaviors of the organic memory devices were attributed to the induced trapping centers. The energy diagram was established to verify the mechanisms.

  2. Bistable (latching) solenoid actuated propellant isolation valve

    NASA Technical Reports Server (NTRS)

    Wichmann, H.; Deboi, H. H.

    1979-01-01

    The design, fabrication, assembly and test of a development configuration bistable (latching) solenoid actuated propellant isolation valve suitable for the control hydrazine and liquid fluorine to an 800 pound thrust rocket engine is described. The valve features a balanced poppet, utilizing metal bellows, a hard poppet/seat interface and a flexure support system for the internal moving components. This support system eliminates sliding surfaces, thereby rendering the valve free of self generated particles.

  3. Voltage impulse induced bistable magnetization switching in multiferroic heterostructures

    NASA Astrophysics Data System (ADS)

    Nan, T. X.; Zhou, Z. Y.; Lou, J.; Liu, M.; Yang, X.; Gao, Y.; Rand, S.; Sun, N. X.

    2012-03-01

    We report on voltage impulse induced reversible bistable magnetization switching in FeGaB/lead zirconate titanate (PZT) multiferroic heterostructures at room temperature. This was realized through strain-mediated magnetoelectric coupling between ferroelectric PZT and ferromagnetic FeGaB layer. Two reversible and stable voltage-impulse induced mechanical strain states were obtained in the PZT by applying an electric field impulse with its amplitude smaller than the electric coercive field, which led to reversible voltage impulse induced bistable magnetization switching. These voltage impulse induced bistable magnetization switching in multiferroic heterostructures provides a promising approach to power efficient bistable magnetization switching that is crucial for information storage.

  4. Rigidity of lattice domes

    NASA Technical Reports Server (NTRS)

    Savelyev, V. A.

    1979-01-01

    The means of ensuring total rigidity of lattice domes, using comparison with solid shells of 1-3 layers are discussed. Irregularities of manufacture, processing, and other factors are considered, as they relate to diminution of rigidity. The discussion uses the concepts of upper and lower critical loads on the structure in question.

  5. [Significance of functional tests in investigation of arterial wall rigidity in patients with chronic obstructive pulmonary disease].

    PubMed

    Gel'tser, B I; Brodskaia, T A; Nevzorova, V A

    2008-01-01

    The aim of the investigation was to study mechanical properties of the aorta in patients with chronic obstructive pulmonary disease (COPD) using functional tests. 60 patients with COPD and 25 healthy volunteers of comparable age were examined by non-invasive arteriography (Tensio Clinic TL 1 arteriograph, Tensiomed, Hungary) with physical exercise (PE) and nitroglycerin test (NT). Oxygen saturation and the basal serum concentration of nitric oxide were measured. The study found a significant decrease in aortal reactivity after PE in patients with II to III stage COPD vs. healthy persons. The degree of this decrease correlates with the duration and severity of the disease, the degree of ventilatory disturbances, hypoxemia and hyponitrooxidemia. According to non-invasive arteriography, the relative coronary perfusion index during NT was most sensitive to COPD severity when PE test was performed. It was 10 times worse in patients with COPD III vs. healthy persons. The degree of a decrease in the velocity of the spread of pulse wave in the aorta (VSPW) and augmentation index during NT was the same in COPD patients and healthy persons, while in COPD II the sensitivity of these parameters was higher. Study of the mechanic properties of aorta using functional tests substantially complements possibilities provided by conventional arteriography. For instance, some of COPD patients with "optimal" VSPW at rest display a significantly decreased response to PE. PMID:18494284

  6. Magnetic bistability and Overhauser shift of conduction electrons in gallium oxide

    NASA Astrophysics Data System (ADS)

    Aubay, Eric; Gourier, Didier

    1993-06-01

    We study the intrinsic magnetic bistability of conduction-electron spins in gallium oxide β-Ga2O3 by electron-paramagnetic-resonance (EPR) spectroscopy. This compound, normally an insulator, becomes an n-type semiconductor when synthesized under reducing conditions. The crystals studied in this work have a conductivity of 180-200 Ω-1 cm-1 at room temperature and 140 Ω-1 cm-1 at liquid-helium temperature. It has been previously shown [J. Phys. Chem. 96, 5513 (1992)] that the hyperfine interaction between conduction-electron spins and nuclear spins of gallium is responsible for a strong dynamic nuclear polarization when the EPR of conduction electrons is saturated (Overhauser effect). The resulting nuclear field acting on the electron spins was found to be bistable, which causes a hysteresis of the resonance line. In this work we demonstrate that hysteresis can be theoretically produced by three different control parameters: the external magnetic field B0, the microwave frequency ν, and the microwave field B1 (or the microwave power P). A model is presented for the EPR line shape under bistable dynamic nuclear polarization, which is in fair agreement with experimental results for gallium oxide. We verify in this compound the existence of hysteresis of the EPR intensity upon positive and negative variations of the incident microwave power. The effect of sample size on bistability is also investigated. It is shown that this phenomenon can disappear if the sample size is larger than the skin depth of the compound. Bistability at room temperature in gallium oxide is found to be very sensitive to this size effect. The Overhauser shift of conduction electrons is also studied as a function of temperature. This parameter gives details on the hyperfine interaction between charge carriers and magnetic nuclei despite the extreme motional narrowing of the EPR line. The results are interpreted in terms of electronic transport at low temperatures involving an impurity band

  7. Bistable States of Quantum Dot Array Junctions for High-Density Memory

    NASA Astrophysics Data System (ADS)

    Kuo, David M.-T.; Chang, Yia-Chung

    2009-10-01

    We demonstrate that two-dimensional (2D) arrays of coupled quantum dots (QDs) with six-fold degenerate p orbitals (including spin degeneracy) can display bistable states, suitable for application in high-density memory device with low power consumption. Due to the inter-dot overlap of px,y orbitals in these QD arrays, two dimensional conduction bands can be formed in the x-y plane, while the pz orbitals remain localized in the x-y plane such that the coupling between pz orbitals located at different dots can be neglected. We model such systems by taking into account the on-site repulsive Coulomb interactions (U) between electrons in any of the three p orbitals, which also lead to a coupling between the localized pz orbitals with the 2D conduction bands formed by px/py orbitals. The Green's function method within an extended Anderson model is used to calculate the tunneling current through the QDs. We find that bistable tunneling current can exist for such systems due to the interplay of the on-site Coulomb interactions between the pz orbitals and the delocalized nature of conduction band states derived from the hybridization of px/py orbitals. This bistable current depends critically on the strength of U, the band width, and the ratio of the left and right tunneling rates. The behavior of the electrical bistability can be sustained when the 2D QD array reduces to a one-dimensional (1D) QD array, indicating the feasibility for high-density packing of these bistable nanoscale structures.

  8. Temporal cross-correlation asymmetry and departure from equilibrium in a bistable chemical system.

    PubMed

    Bianca, C; Lemarchand, A

    2014-06-14

    This paper aims at determining sustained reaction fluxes in a nonlinear chemical system driven in a nonequilibrium steady state. The method relies on the computation of cross-correlation functions for the internal fluctuations of chemical species concentrations. By employing Langevin-type equations, we derive approximate analytical formulas for the cross-correlation functions associated with nonlinear dynamics. Kinetic Monte Carlo simulations of the chemical master equation are performed in order to check the validity of the Langevin equations for a bistable chemical system. The two approaches are found in excellent agreement, except for critical parameter values where the bifurcation between monostability and bistability occurs. From the theoretical point of view, the results imply that the behavior of cross-correlation functions cannot be exploited to measure sustained reaction fluxes in a specific nonlinear system without the prior knowledge of the associated chemical mechanism and the rate constants.

  9. Local structure of germanium selenide glasses around the rigidity percolation threshold using atomic pair distribution function and X-ray absorption fine structure techniques

    NASA Astrophysics Data System (ADS)

    Shatnawi, Moneeb Taiseer

    A search for a structural response to a recently proposed self-organized and stress-free intermediate phase [1, 2] in semiconductor chalcogenide Ge xSe1-x glasses has been performed in this study. These glasses, according to the mean-field approach, undergo a structural phase transition from floppy to rigid network that occurs at a mean coordination number of 2.4. Based on thermodynamic and spectroscopic measurements, these glasses appear to exhibit two transitions instead of one [3]. The region between these transitions has been called the intermediate phase (IP) [3, 4]. The original theoretical work assumed that the network was generic and the connectivity random [5]. It was therefore suggested [1] that the IP phase is a region of finite width in composition where the network could self-organize in such a way that maintains a rigid but unstressed state. However, it has proved difficult to establish this result experimentally. High-resolution atomic pair distribution functions (PDF), derived from high energy synchrotron radiation, coupled with high-resolution X-ray absorption fine structure (XAFS) measurements on 18 compositions of well-prepared Ge xSe1-x glasses that span the range of the IP have been performed to elucidate aspects of rigidity percolation and the IP. These data sets are the most complete and the highest resolution data set on this system to date. Analysis of the structure functions (in reciprocal space) and the PDFs (in real space) as well as the XAFS data at both Ge and Se edges show no correlations with the IP. The network evolves smoothly without any break in slope or discontinuity that might be linked due to the IP. The results obtained in this study contradict previously published work [1, 2] that claim experimental evidence for a structural origin of the IP. The so-called first sharp diffraction peak (FSDP), which is a signature of the medium range order in these glasses, changes systematically with Ge content. It develops smoothly from a

  10. Bistable polarization switching in a continuous wave ruby laser

    NASA Technical Reports Server (NTRS)

    Lawandy, N. M.; Afzal, R. Sohrab

    1988-01-01

    Bistability in the output power, polarization state, and mode volume of an argon-ion laser pumped single mode ruby laser at 6943 A has been observed. The laser operates in a radially confined mode which exhibits hysteresis and bistability only when the pump polarization is parallel to the c-axis.

  11. Magnetic-field-induced bistability in resonant tunneling

    NASA Astrophysics Data System (ADS)

    Brown, S. A.; Macks, L. D.

    1998-07-01

    We report an unusual magnetic-field-induced bistability in the current-voltage characteristic of an asymmetric double-barrier resonant tunneling structure. It is suggested that this bistability is the experimental manifestation of self-sustained current oscillations that have recently been predicted by Orellana, Anda, and Claro [Phys. Rev. Lett. 79, 1118 (1997)].

  12. Bistable chiral tilted-homeotropic nematic liquid crystal cells

    NASA Astrophysics Data System (ADS)

    Hsu, Jy-Shan; Liang, Bau-Jy; Chen, Shu-Hsia

    2004-12-01

    A bistable chiral tilted-homeotropic nematic cell which uses dual-frequency liquid crystal is demonstrated. This cell can be switched between the tilted homeotropic state and the twisted state. The switching mechanisms are achieved by the backflow effect together with the anisotropic properties of the dual-frequency liquid crystal material. The experimental results of this bistable cell are described explicitly.

  13. Optical bistability involving photonic crystal microcavities and Fano line shapes.

    PubMed

    Cowan, A R; Young, Jeff F

    2003-10-01

    The reflectivity of a single-channel waveguide mode upon resonantly coupling to a Kerr-active nonlinear resonant cavity is calculated analytically, including the effects of two-photon absorption. The resonant reflectivity takes the form of a Fano resonance because the solution includes linear reflections from perturbations downstream of the localized cavity. Instead of using a Hamiltonian formulation of the scattering problem, an intuitive set of basis states is used to expand the Green's function of the electric field wave equation. All resulting overlap functions describing the linear coupling between guided and localized states, and the nonlinear renormalization of the material's refractive index, are in terms of well-defined physical quantities. Although derived in the context of photonic crystal-based waveguides and cavities, the treatment is valid for any low-loss waveguide-resonator geometry that satisfies specific weak coupling criteria. For a cavity consisting of Al0.18Ga0.82As, hosting a localized mode at 1.55 microm with a Q of 4000 and a mode volume of 0.055 microm(3), we predict the onset of bistable reflection at incident powers of approximately 40 mW. The downstream reflections lead to hysteresis loops in the reflectivity that are topologically distinct from conventional Lorentzian-derived loops characteristic of isolated Fabry-Perot cavities. We provide a stability argument that reveals the unstable branches of these unique hysteresis loops, and we illustrate some of the rich bistable behaviors that can be engineered with such downstream sources. PMID:14683064

  14. Optical bistability in core-shell magnetoplasmonic nanoparticles with magnetocontrollability.

    PubMed

    Yu, W J; Sun, H; Gao, L

    2016-09-19

    We propose a mechanism to actively tune optical bistable behavior with the external magnetic field in nonlinear coated nanospheres with a magneto-optical (MO) shell and nonlinear metallic core. We show that such nanostructures can exhibit typical bistable phenomena near surface plasmon resonant wavelengths, which can be modified through the external magnetic fields B. We demonstrate numerically that the optical bistability exists only when the volume fraction η of the metallic core is larger than a critical one ηc. Moreover, the bistable behavior is found to be dependent on the incident polarization state as well as the external magnetic field. The application of an external magnetic field does not only increase (or decrease) the upper/lower threshold fields but also changes the critical volume fractions. Such nanostructures with magneto-controllable optical bistability may be designed for us as nonlinear optical nanodevices, such as optical nanoswitches, nanosensors and so on. PMID:27661961

  15. Monomeric Bistability and the Role of Autoloops in Gene Regulation

    PubMed Central

    Solé, Ricard

    2009-01-01

    Genetic toggle switches are widespread in gene regulatory networks (GRN). Bistability, namely the ability to choose among two different stable states, is an essential feature of switching and memory devices. Cells have many regulatory circuits able to provide bistability that endow a cell with efficient and reliable switching between different physiological modes of operation. It is often assumed that negative feedbacks with cooperative binding (i.e. the formation of dimers or multimers) are a prerequisite for bistability. Here we analyze the relation between bistability in GRN under monomeric regulation and the role of autoloops under a deterministic setting. Using a simple geometric argument, we show analytically that bistability can also emerge without multimeric regulation, provided that at least one regulatory autoloop is present. PMID:19404388

  16. Weighted sum threshold logic operation of MOBILE (monostable-bistable transition logic element) using resonant-tunneling transistors

    NASA Astrophysics Data System (ADS)

    Akeyoshi, Tomoyuki; Maezawa, Koichi; Mizutani, Takashi

    1993-10-01

    The functional operation of MOBILE (monostable-bistable transition logic element) has been studied using multiple-input logic gates. MOBILE uses two resonant-tunneling transistors (RTT's), connected in series and driven by oscillating bias voltage to produce a mono-to-bistable transition of the circuit. A fabricated MOBILE having three-input gates with a 1:2:4 width ratio can distinguish all 8 (2(exp 3)) input patterns corresponding to each weighted sum, depending on the threshold value selected by the control gate. The results signify the realization of the weighted sum threshold logic operation of input signals.

  17. On the bistable zone of milling processes

    PubMed Central

    Dombovari, Zoltan; Stepan, Gabor

    2015-01-01

    A modal-based model of milling machine tools subjected to time-periodic nonlinear cutting forces is introduced. The model describes the phenomenon of bistability for certain cutting parameters. In engineering, these parameter domains are referred to as unsafe zones, where steady-state milling may switch to chatter for certain perturbations. In mathematical terms, these are the parameter domains where the periodic solution of the corresponding nonlinear, time-periodic delay differential equation is linearly stable, but its domain of attraction is limited due to the existence of an unstable quasi-periodic solution emerging from a secondary Hopf bifurcation. A semi-numerical method is presented to identify the borders of these bistable zones by tracking the motion of the milling tool edges as they might leave the surface of the workpiece during the cutting operation. This requires the tracking of unstable quasi-periodic solutions and the checking of their grazing to a time-periodic switching surface in the infinite-dimensional phase space. As the parameters of the linear structural behaviour of the tool/machine tool system can be obtained by means of standard modal testing, the developed numerical algorithm provides efficient support for the design of milling processes with quick estimates of those parameter domains where chatter can still appear in spite of setting the parameters into linearly stable domains. PMID:26303918

  18. Single coil bistable, bidirectional micromechanical actuator

    SciTech Connect

    Tabat, Ned; Guckel, Henry

    1998-09-15

    Micromechanical actuators capable of bidirectional and bistable operation can be formed on substrates using lithographic processing techniques. Bistable operation of the microactuator is obtained using a single coil and a magnetic core with a gap. A plunger having two magnetic heads is supported for back and forth linear movement with respect to the gap in the magnetic core, and is spring biased to a neutral position in which the two heads are on each side of the gap in the core. The single electrical coil is coupled to the core and is provided with electrical current to attract one of the heads toward the core by reluctance action to drive the plunger to a limit of travel in one direction. The current is then cut off and the plunger returns by spring action toward the gap, whereafter the current is reapplied to the coil to attract the other head of the plunger by reluctance action to drive the plunger to its other limit of travel. This process can be repeated at a time when switching of the actuator is required.

  19. On the bistable zone of milling processes

    PubMed Central

    Dombovari, Zoltan; Stepan, Gabor

    2015-01-01

    A modal-based model of milling machine tools subjected to time-periodic nonlinear cutting forces is introduced. The model describes the phenomenon of bistability for certain cutting parameters. In engineering, these parameter domains are referred to as unsafe zones, where steady-state milling may switch to chatter for certain perturbations. In mathematical terms, these are the parameter domains where the periodic solution of the corresponding nonlinear, time-periodic delay differential equation is linearly stable, but its domain of attraction is limited due to the existence of an unstable quasi-periodic solution emerging from a secondary Hopf bifurcation. A semi-numerical method is presented to identify the borders of these bistable zones by tracking the motion of the milling tool edges as they might leave the surface of the workpiece during the cutting operation. This requires the tracking of unstable quasi-periodic solutions and the checking of their grazing to a time-periodic switching surface in the infinite-dimensional phase space. As the parameters of the linear structural behaviour of the tool/machine tool system can be obtained by means of standard modal testing, the developed numerical algorithm provides efficient support for the design of milling processes with quick estimates of those parameter domains where chatter can still appear in spite of setting the parameters into linearly stable domains. PMID:26303918

  20. Electroencephalograph (EEG) study of brain bistable illusion

    NASA Astrophysics Data System (ADS)

    Meng, Qinglei; Hong, Elliot; Choa, Fow-Sen

    2015-05-01

    Bistable illusion reflects two different kinds of interpretations for a single image, which is currently known as a competition between two groups of antagonism of neurons. Recent research indicates that these two groups of antagonism of neurons express different comprehension, while one group is emitting a pulse, the other group will be restrained. On the other hand, when this inhibition mechanism becomes weaker, the other antagonism neurons group will take over the interpretation. Since attention plays key roles controlling cognition, is highly interesting to find the location and frequency band used by brain (with either top-down or bottom-up control) to reach deterministic visual perceptions. In our study, we used a 16-channel EEG system to record brain signals from subjects while conducting bistable illusion testing. An extra channel of the EEG system was used for temporal marking. The moment when subjects reach a perception switch, they click the channel and mark the time. The recorded data were presented in form of brain electrical activity map (BEAM) with different frequency bands for analysis. It was found that the visual cortex in the on the right side between parietal and occipital areas was controlling the switching of perception. In the periods with stable perception, we can constantly observe all the delta, theta, alpha and beta waves. While the period perception is switching, almost all theta, alpha, and beta waves were suppressed by delta waves. This result suggests that delta wave may control the processing of perception switching.

  1. On the bistable zone of milling processes.

    PubMed

    Dombovari, Zoltan; Stepan, Gabor

    2015-09-28

    A modal-based model of milling machine tools subjected to time-periodic nonlinear cutting forces is introduced. The model describes the phenomenon of bistability for certain cutting parameters. In engineering, these parameter domains are referred to as unsafe zones, where steady-state milling may switch to chatter for certain perturbations. In mathematical terms, these are the parameter domains where the periodic solution of the corresponding nonlinear, time-periodic delay differential equation is linearly stable, but its domain of attraction is limited due to the existence of an unstable quasi-periodic solution emerging from a secondary Hopf bifurcation. A semi-numerical method is presented to identify the borders of these bistable zones by tracking the motion of the milling tool edges as they might leave the surface of the workpiece during the cutting operation. This requires the tracking of unstable quasi-periodic solutions and the checking of their grazing to a time-periodic switching surface in the infinite-dimensional phase space. As the parameters of the linear structural behaviour of the tool/machine tool system can be obtained by means of standard modal testing, the developed numerical algorithm provides efficient support for the design of milling processes with quick estimates of those parameter domains where chatter can still appear in spite of setting the parameters into linearly stable domains.

  2. Resonant Tunneling and Intrinsic Bistability in Twisted Graphene Structures

    NASA Astrophysics Data System (ADS)

    Rodriguez-Nieva, Joaquin; Dresselhaus, Mildred; Levitov, Leonid

    2015-03-01

    Bistable systems exhibit several distinct macroscopic states and can switch between them upon variation of some control parameter. Nonvolatile electronic systems that exhibit intrinsic bistability and fast switching times are desirable for low-power memory and logic. Experimental realizations of such systems, however, are scarce. We propose a novel mechanism for intrinsic bistability in van der Waals heterostructures formed by twisted graphene monolayers. Bistability in these systems originates from resonant tunneling and charge coupling between different graphene layers. These characteristics, governed by Dirac-like spectrum and Moiré periodicity of the tunneling Hamiltonian, allow multiple stable states in the sequential tunneling regime. In the bistability region, an intermediate electrically decoupled graphene layer can, for the same external bias, be either in a resonant or non-resonant state with respect to the top/bottom layer. Features of interest, such as resonant tunneling, negative differential resistance and bistability, are controlled by parameters easily accessible in experiments, namely the twist angle and interlayer conductances. We estimate the power required to retain this state, switching times, and assess volatility of such intrinsically bistable systems.

  3. Stability and morphing characteristics of bistable composite laminates

    NASA Astrophysics Data System (ADS)

    Tawfik, Samer A.

    The focus of the current research is to investigate the potential of using bistable unsymmetric cross-ply laminated composites as a means for achieving structures with morphed characteristics. To this end, an investigation of the design space for laminated composites exhibiting bistable behavior is undertaken and the key parameters controlling their behavior are identified. For this purpose a nonlinear Finite Element methodology using ABAQUS(TM) code is developed to predict both the cured shapes and the stability characteristics of unsymmetric cross-ply laminates. In addition, an experimental program is developed to validate the analytically predicted results through comparison with test data. A new method is proposed for attaching piezoelectric actuators to a bistable panel in order to preserve its favorable stability characteristics as well as optimizing the actuators performance. The developed nonlinear FE methodology is extended to predict the actuation requirements of bistable panels. Actuator requirements, predicted using the nonlinear FE analysis, are found to be in agreement with the test results. The current research also explores the potential for implementing bistable panels for Uninhabited Aerial Vehicle (UAV) wing configuration. To this end, a set of bistable panels is manufactured by combining symmetric and unsymmetric balanced and unbalanced stacking sequence and their stability characteristics are predicted. A preliminary analysis of the aerodynamic characteristics of the manufactured panels is carried out and the aerodynamic benefits of manufactured bistable panel are noted.

  4. pH and light-controlled self-assembly of bistable [c2] daisy chain rotaxanes.

    PubMed

    Wolf, Adrian; Moulin, Emilie; Cid, Juan-José; Goujon, Antoine; Du, Guangyan; Busseron, Eric; Fuks, Gad; Giuseppone, Nicolas

    2015-03-11

    A logic gate based on a bistable [c2] daisy chain rotaxane decorated with lateral triarylamine units is described, giving rise to an INHIBIT logic function using proton concentration and light as inputs, and producing dual color change and supramolecular self-assembly as outputs. PMID:25661046

  5. Bistability and steady-state spin squeezing in diamond nanostructures controlled by a nanomechanical resonator

    NASA Astrophysics Data System (ADS)

    Ma, Yong-Hong; Zhang, Xue-Feng; Song, Jie; Wu, E.

    2016-06-01

    As the quantum states of nitrogen vacancy (NV) center can be coherently manipulated and obtained at room temperature, it is important to generate steady-state spin squeezing in spin qubits associated with NV impurities in diamond. With this task we consider a new type of a hybrid magneto-nano-electromechanical resonator, the functionality of which is based on a magnetic-field induced deflection of an appropriate cantilever that oscillates between NV spins in diamond. We show that there is bistability and spin squeezing state due to the presence of the microwave field, despite the damping from mechanical damping. Moreover, we find that bistability and spin squeezing can be controlled by the microwave field and the parameter Vz. Our scheme may have the potential application on spin clocks, magnetometers, and other measurements based on spin-spin system in diamond nanostructures.

  6. Modulating resonance behaviors by noise recycling in bistable systems with time delay

    SciTech Connect

    Sun, Zhongkui Xu, Wei; Yang, Xiaoli; Xiao, Yuzhu

    2014-06-01

    In this paper, the impact of noise recycling on resonance behaviors is studied theoretically and numerically in a prototypical bistable system with delayed feedback. According to the interior cooperating and interacting activity of noise recycling, a theory has been proposed by reducing the non-Markovian problem into a two-state model, wherein both the master equation and the transition rates depend on not only the current state but also the earlier two states due to the recycling lag and the feedback delay. By virtue of this theory, the formulae of the power spectrum density and the linear response function have been found analytically. And the theoretical results are well verified by numerical simulations. It has been demonstrated that both the recycling lag and the feedback delay play a crucial role in the resonance behaviors. In addition, the results also suggest an alternative scheme to modulate or control the coherence or stochastic resonance in bistable systems with time delay.

  7. A new bistable electroactive polymer for prolonged cycle lifetime of refreshable Braille displays

    NASA Astrophysics Data System (ADS)

    Ren, Zhi; Niu, Xiaofan; Chen, Dustin; Hu, Wei; Pei, Qibing

    2014-03-01

    ABSTRACT: Bistable electroactive polymers (BSEP) amalgamating electrically induced large-strain actuation and shape memory effect present a unique opportunity for refreshable Braille displays. A new BSEP material with long-chain crosslinkers to achieve prolonged cycle lifetime of refreshable Braille displays is reported here. The modulus of the BSEP material decreases by more than three orders of magnitude from a rigid, plastic state to a rubbery state when heated above the polymer's glass transition temperature. In its rubbery state, the polymer film can be electrically actuated to buckle convexly when a high voltage is applied across a circular active area. Modifying the concentration of long-chain crosslinkers in the polymer allows not only for fine-tuning of the polymer's glass transition temperature and elasticity in the rubbery state, but also enhancement of the actuation stability. For a raised height of 0.4 mm by a Braille dot with a 1.3 mm diameter, actuation can be repeated over 2000 cycles at 70°C in the rubbery state. The actuated dome shape can be fixed by cooling the polymer below the glass transition temperature. This refreshable rigid-to-rigid actuation simultaneously provides large-strain actuation and large force support. Devices capable of displaying Braille characters over a page-size area consisting of 324 Braille cells have been fabricated.

  8. Resonant tunneling and intrinsic bistability in twisted graphene structures

    NASA Astrophysics Data System (ADS)

    Rodriguez-Nieva, J. F.; Dresselhaus, M. S.; Levitov, L. S.

    2016-08-01

    We predict that vertical transport in heterostructures formed by twisted graphene layers can exhibit a unique bistability mechanism. Intrinsically bistable I -V characteristics arise from resonant tunneling and interlayer charge coupling, enabling multiple stable states in the sequential tunneling regime. We consider a simple trilayer architecture, with the outer layers acting as the source and drain and the middle layer floating. Under bias, the middle layer can be either resonant or nonresonant with the source and drain layers. The bistability is controlled by geometric device parameters easily tunable in experiments. The nanoscale architecture can enable uniquely fast switching times.

  9. Feedback-induced bistability of an optically levitated nanoparticle: A Fokker-Planck treatment

    NASA Astrophysics Data System (ADS)

    Ge, Wenchao; Rodenburg, Brandon; Bhattacharya, M.

    2016-08-01

    Optically levitated nanoparticles have recently emerged as versatile platforms for investigating macroscopic quantum mechanics and enabling ultrasensitive metrology. In this paper we theoretically consider two damping regimes of an optically levitated nanoparticle cooled by cavityless parametric feedback. Our treatment is based on a generalized Fokker-Planck equation derived from the quantum master equation presented recently and shown to agree very well with experiment [B. Rodenburg, L. P. Neukirch, A. N. Vamivakas, and M. Bhattacharya, Quantum model of cooling and force sensing with an optically trapped nanoparticle, Optica 3, 318 (2016), 10.1364/OPTICA.3.000318]. For low damping, we find that the resulting Wigner function yields the single-peaked oscillator position distribution and recovers the appropriate energy distribution derived earlier using a classical theory and verified experimentally [J. Gieseler, R. Quidant, C. Dellago, and L. Novotny, Dynamic relaxation of a levitated nanoparticle from a non-equilibrium steady state, Nat. Nano. 9, 358 (2014), 10.1038/nnano.2014.40]. For high damping, in contrast, we predict a double-peaked position distribution, which we trace to an underlying bistability induced by feedback. Unlike in cavity-based optomechanics, stochastic processes play a major role in determining the bistable behavior. To support our conclusions, we present analytical expressions as well as numerical simulations using the truncated Wigner function approach. Our work opens up the prospect of developing bistability-based devices, characterization of phase-space dynamics, and investigation of the quantum-classical transition using levitated nanoparticles.

  10. Concurrent design of a morphing aerofoil with variable stiffness bi-stable laminates

    NASA Astrophysics Data System (ADS)

    Kuder, I. K.; Fasel, U.; Ermanni, P.; Arrieta, A. F.

    2016-11-01

    Morphing systems able to efficiently adjust their characteristics to resolve the conflicting demands of changing operating conditions offer great potential for enhanced performance and functionality. The main practical challenge, however, consists in combining the desired compliance to accomplish radical reversible geometry modifications at reduced actuation effort with the requirement of high stiffness imposed by operational functions. A potential decoupling strategy entails combining the conformal shape adaptation benefits of distributed compliance with purely elastic stiffness variability provided by embedded bi-stable laminates. This selective compliance can allow for on-demand stiffness adaptation by switching between the stable states of the internal elements. The current paper considers the optimal positioning of the bi-stable components within the structure while assessing the energy required for morphing under aerodynamic loading. Compared to a time-invariant system, activating specific deformation modes permits decreasing the amount of actuation energy, and hence the amount of actuation material to be carried. A concurrent design and optimisation framework is implemented to develop selective configurations targeting different flight conditions. First, an aerodynamically favourable high-lift mode achieves large geometric changes due to reduced actuation demands. This is only possible by virtue of the internally tailored compliance, arising from the stable state switch of the embedded bi-stable components. A second, stiff configuration, targets operation under increased aerodynamic loading. The dynamic adequacy of the design is proved via high fidelity fluid–structure interaction simulations.

  11. Rigidity of melting DNA.

    PubMed

    Pal, Tanmoy; Bhattacharjee, Somendra M

    2016-05-01

    The temperature dependence of DNA flexibility is studied in the presence of stretching and unzipping forces. Two classes of models are considered. In one case the origin of elasticity is entropic due to the polymeric correlations, and in the other the double-stranded DNA is taken to have an intrinsic rigidity for bending. In both cases single strands are completely flexible. The change in the elastic constant for the flexible case due to thermally generated bubbles is obtained exactly. For the case of intrinsic rigidity, the elastic constant is found to be proportional to the square root of the bubble number fluctuation. PMID:27300825

  12. Rigidity of melting DNA

    NASA Astrophysics Data System (ADS)

    Pal, Tanmoy; Bhattacharjee, Somendra M.

    2016-05-01

    The temperature dependence of DNA flexibility is studied in the presence of stretching and unzipping forces. Two classes of models are considered. In one case the origin of elasticity is entropic due to the polymeric correlations, and in the other the double-stranded DNA is taken to have an intrinsic rigidity for bending. In both cases single strands are completely flexible. The change in the elastic constant for the flexible case due to thermally generated bubbles is obtained exactly. For the case of intrinsic rigidity, the elastic constant is found to be proportional to the square root of the bubble number fluctuation.

  13. Flexible and rigid amine-functionalized microporous frameworks based on different secondary building units: supramolecular isomerism, selective CO(2) capture, and catalysis.

    PubMed

    Haldar, Ritesh; Reddy, Sandeep K; Suresh, Venkata M; Mohapatra, Sudip; Balasubramanian, Sundaram; Maji, Tapas Kumar

    2014-04-01

    We report the synthesis, structural characterization, and porous properties of two isomeric supramolecular complexes of ([Cd(NH2 bdc)(bphz)0.5 ]⋅DMF⋅H2 O}n (NH2 bdc=2-aminobenzenedicarboxylic acid, bphz=1,2-bis(4-pyridylmethylene)hydrazine) composed of a mixed-ligand system. The first isomer, with a paddle-wheel-type Cd2 (COO)4 secondary building unit (SBU), is flexible in nature, whereas the other isomer has a rigid framework based on a μ-oxo-bridged Cd2 (μ-OCO)2 SBU. Both frameworks are two-fold interpenetrated and the pore surface is decorated with pendant -NH2 and NN functional groups. Both the frameworks are nonporous to N2 , revealed by the type II adsorption profiles. However, at 195 K, the first isomer shows an unusual double-step hysteretic CO2 adsorption profile, whereas the second isomer shows a typical type I CO2 profile. Moreover, at 195 K, both frameworks show excellent selectivity for CO2 among other gases (N2 , O2 , H2 , and Ar), which has been correlated to the specific interaction of CO2 with the -NH2 and NN functionalized pore surface. DFT calculations for the oxo-bridged isomer unveiled that the -NH2 group is the primary binding site for CO2 . The high heat of CO2 adsorption (ΔHads =37.7 kJ mol(-1) ) in the oxo-bridged isomer is realized by NH2 ⋅⋅⋅CO2 /aromatic π⋅⋅⋅CO2 and cooperative CO2 ⋅⋅⋅CO2 interactions. Further, postsynthetic modification of the -NH2 group into -NHCOCH3 in the second isomer leads to a reduced CO2 uptake with lower binding energy, which establishes the critical role of the -NH2 group for CO2 capture. The presence of basic -NH2 sites in the oxo-bridged isomer was further exploited for efficient catalytic activity in a Knoevenagel condensation reaction.

  14. Synthesizing A Phase Changing Bistable Electroactive Polymer And Silver Nanoparticles Coated Fabric As A Resistive Heating Element

    NASA Astrophysics Data System (ADS)

    Ren, Zhi

    Transducer technologies that convert energy from one form to another (e.g. electrical energy to mechanical energy or thermal energy and vise versa) are considered as the basic building blocks of robots and wearable electronics, two of the rapidly emerging technologies that impact our daily life. With an emphasis on developing the essential smart materials, this dissertation focuses on two specific transducer technologies, bistable large-strain electro-mechanical actuation and resistive Joule heating, in pursuit of refreshable Braille electronic displays and wearable thermal management element, respectively. Dielectric elastomers (DEs) have been intensively studied for their promising ability to mimic human muscles in providing efficient electro-mechanical actuation. They exhibit a unique combination of properties, including large strain, fast response, high energy density, mechanical compliancy, lightweight, and low cost. However, the softness of the DE materials, which is a prerequisite for electrically induced large actuation strain, has been hindering their application in adaptive structures. In these applications such as braille displays, a certain amount of mechanical support is necessary in addition to large strains for the device or system to function. Bistable electroactive polymers (BSEP) that leverage the electrically induced large-strain actuation of DE actuators and the bi-stable rigid-to-rigid deformation of shape memory polymers are innovated to provide large electrical actuation strain in their rubbery state and fix the deformation by cooling down to room temperature to incorporate mechanical rigidity. BSEP materials that can suppress electromechanical instability and exhibit stable mechanical properties in the rubbery state are desired. A bimodal BSEP material with a glass transition temperature right above room temperature has been synthesized employing simple UV curing process. The BSEP has a large storage modulus over 1GPa at room temperature

  15. Bistability in a Driven-Dissipative Superfluid.

    PubMed

    Labouvie, Ralf; Santra, Bodhaditya; Heun, Simon; Ott, Herwig

    2016-06-10

    We experimentally study a driven-dissipative Josephson junction array, realized with a weakly interacting Bose-Einstein condensate residing in a one-dimensional optical lattice. Engineered losses on one site act as a local dissipative process, while tunneling from the neighboring sites constitutes the driving force. We characterize the emerging steady states of this atomtronic device. With increasing dissipation strength γ the system crosses from a superfluid state, characterized by a coherent Josephson current into the lossy site, to a resistive state, characterized by an incoherent hopping transport. For intermediate values of γ, the system exhibits bistability, where a superfluid and an incoherent branch coexist. We also study the relaxation dynamics towards the steady state, where we find a critical slowing down, indicating the presence of a nonequilibrium phase transition. PMID:27341243

  16. Bistability in a Driven-Dissipative Superfluid

    NASA Astrophysics Data System (ADS)

    Labouvie, Ralf; Santra, Bodhaditya; Heun, Simon; Ott, Herwig

    2016-06-01

    We experimentally study a driven-dissipative Josephson junction array, realized with a weakly interacting Bose-Einstein condensate residing in a one-dimensional optical lattice. Engineered losses on one site act as a local dissipative process, while tunneling from the neighboring sites constitutes the driving force. We characterize the emerging steady states of this atomtronic device. With increasing dissipation strength γ the system crosses from a superfluid state, characterized by a coherent Josephson current into the lossy site, to a resistive state, characterized by an incoherent hopping transport. For intermediate values of γ , the system exhibits bistability, where a superfluid and an incoherent branch coexist. We also study the relaxation dynamics towards the steady state, where we find a critical slowing down, indicating the presence of a nonequilibrium phase transition.

  17. Bistable Boundary Reactions in Two Dimensions

    NASA Astrophysics Data System (ADS)

    Dávila, Juan; del Pino, Manuel; Musso, Monica

    2011-04-01

    In a bounded domain {Ω subset mathbb R^2} with smooth boundary we consider the problem Δ u = 0 quad {{in }} Ω, qquad partial u/partial ν = frac1\\varepsilon f(u) quad {{on }} partialΩ, where ν is the unit normal exterior vector, ɛ > 0 is a small parameter and f is a bistable nonlinearity such as f( u) = sin( π u) or f( u) = (1 - u 2) u. We construct solutions that develop multiple transitions from -1 to 1 and vice-versa along a connected component of the boundary ∂Ω. We also construct an explicit solution when Ω is a disk and f( u) = sin( π u).

  18. Bifurcation of transition paths induced by coupled bistable systems.

    PubMed

    Tian, Chengzhe; Mitarai, Namiko

    2016-06-01

    We discuss the transition paths in a coupled bistable system consisting of interacting multiple identical bistable motifs. We propose a simple model of coupled bistable gene circuits as an example and show that its transition paths are bifurcating. We then derive a criterion to predict the bifurcation of transition paths in a generalized coupled bistable system. We confirm the validity of the theory for the example system by numerical simulation. We also demonstrate in the example system that, if the steady states of individual gene circuits are not changed by the coupling, the bifurcation pattern is not dependent on the number of gene circuits. We further show that the transition rate exponentially decreases with the number of gene circuits when the transition path does not bifurcate, while a bifurcation facilitates the transition by lowering the quasi-potential energy barrier.

  19. Bistable responses in bacterial genetic networks: Designs and dynamical consequences

    PubMed Central

    Tiwari, Abhinav; Ray, J. Christian J.; Narula, Jatin; Igoshin, Oleg A.

    2011-01-01

    A key property of living cells is their ability to react to stimuli with specific biochemical responses. These responses can be understood through the dynamics of underlying biochemical and genetic networks. Evolutionary design principles have been well studied in networks that display graded responses, with a continuous relationship between input signal and system output. Alternatively, biochemical networks can exhibit bistable responses so that over a range of signals the network possesses two stable steady states. In this review, we discuss several conceptual examples illustrating network designs that can result in a bistable response of the biochemical network. Next, we examine manifestations of these designs in bacterial master-regulatory genetic circuits. In particular, we discuss mechanisms and dynamic consequences of bistability in three circuits: two-component systems, sigma-factor networks, and a multistep phosphorelay. Analyzing these examples allows us to expand our knowledge of evolutionary design principles for networks with bistable responses. PMID:21385588

  20. On the Selection of Bistability in Genetic Regulatory Circuits

    NASA Astrophysics Data System (ADS)

    Ghim, Cheol-Min; Almaas, Eivind

    2008-03-01

    Bistability is a defining character of switching and memory devices. Many regulatory circuits observed in cellular reaction networks contain ``bistability motifs'' that endow a cell with efficient and reliable switching between different physiological modes of operation. One of the best characterized system, the lac operon in E. coli, has been shown to display a saddle-node bifurcation when induced by nonmetabolizable lactose analogue inducers, such as isopropylthio-β-D-galactoside (IPTG) and thio-methyl-galactoside (TMG). Motivated by the absence of bifurcation in the same system with its natural inducer, lactose, we studied the conditions for bistability and rationalized its fitness effects in the light of evolution. Stochastic simulations as well as mean-field approach confirm that history-dependent behavior as well as nongenetic inheritance, being realized by bistability motifs, may be beneficial in fluctuating environments.

  1. Bifurcation of transition paths induced by coupled bistable systems.

    PubMed

    Tian, Chengzhe; Mitarai, Namiko

    2016-06-01

    We discuss the transition paths in a coupled bistable system consisting of interacting multiple identical bistable motifs. We propose a simple model of coupled bistable gene circuits as an example and show that its transition paths are bifurcating. We then derive a criterion to predict the bifurcation of transition paths in a generalized coupled bistable system. We confirm the validity of the theory for the example system by numerical simulation. We also demonstrate in the example system that, if the steady states of individual gene circuits are not changed by the coupling, the bifurcation pattern is not dependent on the number of gene circuits. We further show that the transition rate exponentially decreases with the number of gene circuits when the transition path does not bifurcate, while a bifurcation facilitates the transition by lowering the quasi-potential energy barrier. PMID:27276971

  2. Bifurcation of transition paths induced by coupled bistable systems

    NASA Astrophysics Data System (ADS)

    Tian, Chengzhe; Mitarai, Namiko

    2016-06-01

    We discuss the transition paths in a coupled bistable system consisting of interacting multiple identical bistable motifs. We propose a simple model of coupled bistable gene circuits as an example and show that its transition paths are bifurcating. We then derive a criterion to predict the bifurcation of transition paths in a generalized coupled bistable system. We confirm the validity of the theory for the example system by numerical simulation. We also demonstrate in the example system that, if the steady states of individual gene circuits are not changed by the coupling, the bifurcation pattern is not dependent on the number of gene circuits. We further show that the transition rate exponentially decreases with the number of gene circuits when the transition path does not bifurcate, while a bifurcation facilitates the transition by lowering the quasi-potential energy barrier.

  3. The effects of intrinsic noise on the behaviour of bistable cell regulatory systems under quasi-steady state conditions

    SciTech Connect

    Cruz, Roberto; Alarcón, Tomás de la; Guerrero, Pilar; Spill, Fabian

    2015-08-21

    We analyse the effect of intrinsic fluctuations on the properties of bistable stochastic systems with time scale separation operating under quasi-steady state conditions. We first formulate a stochastic generalisation of the quasi-steady state approximation based on the semi-classical approximation of the partial differential equation for the generating function associated with the chemical master equation. Such approximation proceeds by optimising an action functional whose associated set of Euler-Lagrange (Hamilton) equations provides the most likely fluctuation path. We show that, under appropriate conditions granting time scale separation, the Hamiltonian can be re-scaled so that the set of Hamilton equations splits up into slow and fast variables, whereby the quasi-steady state approximation can be applied. We analyse two particular examples of systems whose mean-field limit has been shown to exhibit bi-stability: an enzyme-catalysed system of two mutually inhibitory proteins and a gene regulatory circuit with self-activation. Our theory establishes that the number of molecules of the conserved species is order parameters whose variation regulates bistable behaviour in the associated systems beyond the predictions of the mean-field theory. This prediction is fully confirmed by direct numerical simulations using the stochastic simulation algorithm. This result allows us to propose strategies whereby, by varying the number of molecules of the three conserved chemical species, cell properties associated to bistable behaviour (phenotype, cell-cycle status, etc.) can be controlled.

  4. The effects of intrinsic noise on the behaviour of bistable cell regulatory systems under quasi-steady state conditions

    NASA Astrophysics Data System (ADS)

    de la Cruz, Roberto; Guerrero, Pilar; Spill, Fabian; Alarcón, Tomás

    2015-08-01

    We analyse the effect of intrinsic fluctuations on the properties of bistable stochastic systems with time scale separation operating under quasi-steady state conditions. We first formulate a stochastic generalisation of the quasi-steady state approximation based on the semi-classical approximation of the partial differential equation for the generating function associated with the chemical master equation. Such approximation proceeds by optimising an action functional whose associated set of Euler-Lagrange (Hamilton) equations provides the most likely fluctuation path. We show that, under appropriate conditions granting time scale separation, the Hamiltonian can be re-scaled so that the set of Hamilton equations splits up into slow and fast variables, whereby the quasi-steady state approximation can be applied. We analyse two particular examples of systems whose mean-field limit has been shown to exhibit bi-stability: an enzyme-catalysed system of two mutually inhibitory proteins and a gene regulatory circuit with self-activation. Our theory establishes that the number of molecules of the conserved species is order parameters whose variation regulates bistable behaviour in the associated systems beyond the predictions of the mean-field theory. This prediction is fully confirmed by direct numerical simulations using the stochastic simulation algorithm. This result allows us to propose strategies whereby, by varying the number of molecules of the three conserved chemical species, cell properties associated to bistable behaviour (phenotype, cell-cycle status, etc.) can be controlled.

  5. Electrostatics of Rigid Polyelectrolytes

    SciTech Connect

    Wong, G.C.L.

    2009-06-04

    The organization of rigid biological polyelectrolytes by multivalent ions and macroions are important for many fundamental problems in biology and biomedicine, such as cytoskeletal regulation and antimicrobial sequestration in cystic fibrosis. These polyelectrolytes have been used as model systems for understanding electrostatics in complex fluids. Here, we review some recent results in theory, simulations, and experiments.

  6. Effective rigidity of membranes

    NASA Astrophysics Data System (ADS)

    Peliti, L.

    1986-12-01

    The role of thermal fluctuations of shape (undulations) in reducing the effective rigidity of membranes is reviewed. The consequences of this effect on vesicle size distribution and on the structure of microemulsions, as well as on other physical phenomena, are sketched.

  7. Rigid molecular foams

    SciTech Connect

    Steckle, W.P. Jr.; Mitchell, M.A.; Aspen, P.G.

    1998-12-31

    This is the final report of a three-year, Laboratory Directed Research and Development (LDRD) project at the Los Alamos National Laboratory (LANL). Organic analogues to inorganic zeolites would be a significant step forward in engineered porous materials and would provide advantages in range, selectivity, tailorability, and processing. Rigid molecular foams or {open_quotes}organic zeolites{close_quotes} would not be crystalline materials and could be tailored over a broader range of pore sizes and volumes. A novel process for preparing hypercrosslinked polymeric foams has been developed via a Friedel-Crafts polycondensation reaction. A series of rigid hypercrosslinked foams have been prepared using simple rigid polyaromatic hydrocarbons including benzene, biphenyl, m-terphenyl, diphenylmethane, and polystyrene, with dichloroxylene (DCX) as the pore size. After drying the foams are robust and rigid. Densities of the resulting foams can range from 0.15 g/cc to 0.75 g/cc. Nitrogen adsorption studies have shown that by judiciously selecting monomers and the crosslinking agent along with the level of crosslinking and the cure time of the resulting gel, the pore size, pore size distribution, and the total surface area of the foam can be tailored. Surface areas range from 160 to 1,200 m{sup 2}/g with pore sizes ranging from 6 {angstrom} to 2,000 {angstrom}.

  8. Analytic descriptions of stochastic bistable systems under force ramp

    DOE PAGES

    Friddle, Raymond W.

    2016-05-13

    Solving the two-state master equation with time-dependent rates, the ubiquitous driven bistable system, is a long-standing problem that does not permit a complete solution for all driving rates. We show an accurate approximation to this problem by considering the system in the control parameter regime. Moreover, the results are immediately applicable to a diverse range of bistable systems including single-molecule mechanics.

  9. Analytic descriptions of stochastic bistable systems under force ramp.

    PubMed

    Friddle, Raymond W

    2016-05-01

    Solving the two-state master equation with time-dependent rates, the ubiquitous driven bistable system, is a long-standing problem that does not permit a complete solution for all driving rates. Here we show an accurate approximation to this problem by considering the system in the control parameter regime. The results are immediately applicable to a diverse range of bistable systems including single-molecule mechanics. PMID:27300849

  10. Alternation rate in perceptual bistability is maximal at and symmetric around equi-dominance.

    PubMed

    Moreno-Bote, Rubén; Shpiro, Asya; Rinzel, John; Rubin, Nava

    2010-01-01

    When an ambiguous stimulus is viewed for a prolonged time, perception alternates between the different possible interpretations of the stimulus. The alternations seem haphazard, but closer inspection of their dynamics reveals systematic properties in many bistable phenomena. Parametric manipulations result in gradual changes in the fraction of time a given interpretation dominates perception, often over the entire possible range of zero to one. The mean dominance durations of the competing interpretations can also vary over wide ranges (from less than a second to dozens of seconds or more), but finding systematic relations in how they vary has proven difficult. Following the pioneering work of W. J. M. Levelt (1968) in binocular rivalry, previous studies have sought to formulate a relation in terms of the effect of physical parameters of the stimulus, such as image contrast in binocular rivalry. However, the link between external parameters and "stimulus strength" is not as obvious for other bistable phenomena. Here we show that systematic relations readily emerge when the mean dominance durations are examined instead as a function of "percept strength," as measured by the fraction of dominance time, and provide theoretical rationale for this observation. For three different bistable phenomena, plotting the mean dominance durations of the two percepts against the fraction of dominance time resulted in complementary curves with near-perfect symmetry around equi-dominance (the point where each percept dominates half the time). As a consequence, the alternation rate reaches a maximum at equi-dominance. We next show that the observed behavior arises naturally in simple double-well energy models and in neural competition models with cross-inhibition and input normalization. Finally, we discuss the possibility that bistable perceptual switches reflect a perceptual "exploratory" strategy, akin to foraging behavior, which leads naturally to maximal alternation rate at equi

  11. Dynamics and bistability in a reduced model of the lac operon.

    PubMed

    Yildirim, Necmettin; Santillan, Moises; Horike, Daisuke; Mackey, Michael C

    2004-06-01

    It is known that the lac operon regulatory pathway is capable of showing bistable behavior. This is an important complex feature, arising from the nonlinearity of the involved mechanisms, which is essential to understand the dynamic behavior of this molecular regulatory system. To find which of the mechanisms involved in the regulation of the lac operon is the origin of bistability, we take a previously published model which accounts for the dynamics of mRNA, lactose, allolactose, permease and beta-galactosidase involvement and simplify it by ignoring permease dynamics (assuming a constant permease concentration). To test the behavior of the reduced model, three existing sets of data on beta-galactosidase levels as a function of time are simulated and we obtain a reasonable agreement between the data and the model predictions. The steady states of the reduced model were numerically and analytically analyzed and it was shown that it may indeed display bistability, depending on the extracellular lactose concentration and growth rate. PMID:15189056

  12. A broadband bi-stable flow energy harvester based on the wake-galloping phenomenon

    NASA Astrophysics Data System (ADS)

    Alhadidi, A. H.; Daqaq, M. F.

    2016-07-01

    Linear wake-galloping flow energy harvesters have a narrow frequency bandwidth restricted to the lock-in region, where the vortex shedding frequency is close to the natural frequency of the harvester. As a result, their performance is very sensitive to variations in the flow speed around the nominal design value. This letter demonstrates that the lock-in region of a wake-galloping flow energy harvester can be improved by exploiting a bi-stable restoring force. To demonstrate the enhanced performance, the response behavior of a bi-stable piezoelectric cantilever harvester is evaluated in a wind tunnel. A Von Kármán vortex street is generated by placing a rectangular rod in the windward direction of the harvester and the voltage response of the harvester is evaluated as a function of the wind speed. It is shown that, compared to the linear design, bi-stability can be used to improve the steady-state bandwidth considerably.

  13. Dynamics and bistability in a reduced model of the lac operon

    NASA Astrophysics Data System (ADS)

    Yildirim, Necmettin; Santillán, Moisés; Horike, Daisuke; Mackey, Michael C.

    2004-06-01

    It is known that the lac operon regulatory pathway is capable of showing bistable behavior. This is an important complex feature, arising from the nonlinearity of the involved mechanisms, which is essential to understand the dynamic behavior of this molecular regulatory system. To find which of the mechanisms involved in the regulation of the lac operon is the origin of bistability, we take a previously published model which accounts for the dynamics of mRNA, lactose, allolactose, permease and β-galactosidase involvement and simplify it by ignoring permease dynamics (assuming a constant permease concentration). To test the behavior of the reduced model, three existing sets of data on β-galactosidase levels as a function of time are simulated and we obtain a reasonable agreement between the data and the model predictions. The steady states of the reduced model were numerically and analytically analyzed and it was shown that it may indeed display bistability, depending on the extracellular lactose concentration and growth rate.

  14. Bistability of the lac operon during growth of Escherichia coli on lactose and lactose+glucose.

    PubMed

    Narang, Atul; Pilyugin, Sergei S

    2008-05-01

    The lac operon of Escherichia coli can exhibit bistability. Early studies showed that bistability occurs during growth on TMG/succinate and lactose+glucose, but not during growth on lactose. More recently, studies with lacGFP-transfected cells show bistability during growth on TMG/succinate, but not during growth on lactose and lactose+glucose. In the literature, these results are invariably attributed to variations in the destabilizing effect of the positive feedback generated by induction. Specifically, during growth on TMG/succinate, lac induction generates strong positive feedback because the permease stimulates the accumulation of intracellular TMG, which in turn, promotes the synthesis of even more permease. This positive feedback is attenuated during growth on lactose because hydrolysis of intracellular lactose by beta-galactosidase suppresses the stimulatory effect of the permease. It is attenuated even more during growth on lactose + glucose because glucose inhibits the uptake of lactose. But it is clear that the stabilizing effect of dilution also changes dramatically as a function of the medium composition. For instance, during growth on TMG/succinate, the dilution rate of lac permease is proportional to its activity, e, because the specific growth rate is independent of e (it is completely determined by the concentration of succinate). However, during growth on lactose, the dilution rate of the permease is proportional to e2 because the specific growth rate is proportional to the specific lactose uptake rate, which in turn, proportional to e. We show that: (a) This dependence on e2 creates such a strong stabilizing effect that bistability is virtually impossible during growth on lactose, even in the face of the intense positive feedback generated by induction. (b) This stabilizing effect is weakened during growth on lactose+glucose because the specific growth rate on glucose is independent of e, so that the dilution rate once again contains a term that

  15. Coupling Functions for NM-64 and NM Without Lead Derived on the Basis of Calculated Apparent Cutoff Rigidities for CR Latitude Survey from Antarctica to Italy in Minimum of Solar Activity

    NASA Astrophysics Data System (ADS)

    Dorman, L.I.; Danilova, O.A.; Tyasto, M.I.; Ptitsina, N.G.; Villoresi, G.; Iucci, N.; Parisi, M.

    L. I. Dorman (1,2), O. A. Danilova (3), M. I. Tyasto (3), N. G. Ptitsina (3), G. Villoresi (4), N. Iucci (4) and M. Parisi (4) ? (1) Israel Cosmic Ray Center affiliated to Tel Aviv University, Technion and Israel Space Agency, Israel; (2) IZMIRAN, Troitsk, Russia; (3) SPbFIZMIRAN, St. Petersburg, Russia; (4) Dipartimento di Fisica "E. Amaldi", Università "Roma Tre", Rome, Italy In Dorman et al. (2007) it was calculate the apparent cut-off rigidities for the backward route (Antarctica-Italy) of the CR latitude survey performed on a ship during 1996-1997 solar minimum. These computations were done on the basis of results of trajectory calculations for inclined cut-off rigidities for various azimuth and zenith angles (0°, 15°, 30°, 45°, 60°) and azimuth directions changing from 0° to 360° in steps of 45°. The information on integral multiplicities of secondary neutrons detected by neutron monitor in dependence of zenith angle of incoming primary CR particles have been also used. This information is based on the theoretical calculations of meson-nuclear cascades of primary protons with different rigidities arriving to the Earth's atmosphere at zenith angles 0°, 15°, 30°, 45°, 60° and 75°. By using this information and data of CR latitude survey from Antarctica to Italy in minimum of solar activity we determine coupling functions for NM-64 and NM without lead. Reference: L.I. Dorman et al. “Apparent Cutoff Rigidities for Cosmic Ray Latitude Survey from Antarctica to Italy in Minimum of Solar Activity”, Adv. Space Res., 2007 (in press).

  16. Two bi-stability jumps in theoretical wind models for massive stars and the implications for luminous blue variable supernovae

    NASA Astrophysics Data System (ADS)

    Petrov, Blagovest; Vink, Jorick S.; Gräfener, Götz

    2016-05-01

    Luminous blue variables (LBVs) have been suggested to be the direct progenitors of supernova Types IIb and IIn, with enhanced mass loss prior to explosion. However, the mechanism of this mass loss is not yet known. Here, we investigate the qualitative behaviour of theoretical stellar wind mass loss as a function of Teff across two bi-stability jumps in blue supergiant regime and also in proximity to the Eddington limit, relevant for LBVs. To investigate the physical ingredients that play a role in the radiative acceleration we calculate blue supergiant wind models with the CMFGEN non-local thermodynamic equilibrium model atmosphere code over an effective temperature range between 30 000 and 8800 K. Although our aim is not to provide new mass-loss rates for BA supergiants, we study and confirm the existence of two bi-stability jumps in mass-loss rates predicted by Vink et al. However, they are found to occur at somewhat lower Teff (20 000 and 9000 K, respectively) than found previously, which would imply that stars may evolve towards lower Teff before strong mass loss is induced by the bi-stability jumps. When the combined effects of the second bi-stability jump and the proximity to Eddington limit are accounted for, we find a dramatic increase in the mass-loss rate by up to a factor of 30. Further investigation of both bi-stability jumps is expected to lead to a better understanding of discrepancies between empirical modelling and theoretical mass-loss rates reported in the literature, and to provide key inputs for the evolution of both normal AB supergiants and LBVs, as well as their subsequent supernova Type II explosions.

  17. Measurement of the ground-state distributions in bistable mechanically interlocked molecules using slow scan rate cyclic voltammetry

    PubMed Central

    Fahrenbach, Albert C.; Barnes, Jonathan C.; Li, Hao; Benítez, Diego; Basuray, Ashish N.; Fang, Lei; Sue, Chi-Hau; Barin, Gokhan; Dey, Sanjeev K.; Goddard, William A.; Stoddart, J. Fraser

    2011-01-01

    In donor–acceptor mechanically interlocked molecules that exhibit bistability, the relative populations of the translational isomers—present, for example, in a bistable [2]rotaxane, as well as in a couple of bistable [2]catenanes of the donor–acceptor vintage—can be elucidated by slow scan rate cyclic voltammetry. The practice of transitioning from a fast scan rate regime to a slow one permits the measurement of an intermediate redox couple that is a function of the equilibrium that exists between the two translational isomers in the case of all three mechanically interlocked molecules investigated. These intermediate redox potentials can be used to calculate the ground-state distribution constants, K. Whereas, (i) in the case of the bistable [2]rotaxane, composed of a dumbbell component containing π-electron-rich tetrathiafulvalene and dioxynaphthalene recognition sites for the ring component (namely, a tetracationic cyclophane, containing two π-electron-deficient bipyridinium units), a value for K of 10 ± 2 is calculated, (ii) in the case of the two bistable [2]catenanes—one containing a crown ether with tetrathiafulvalene and dioxynaphthalene recognition sites for the tetracationic cyclophane, and the other, tetrathiafulvalene and butadiyne recognition sites—the values for K are orders (one and three, respectively) of magnitude greater. This observation, which has also been probed by theoretical calculations, supports the hypothesis that the extra stability of one translational isomer over the other is because of the influence of the enforced side-on donor–acceptor interactions brought about by both π-electron-rich recognition sites being part of a macrocyclic polyether. PMID:22135467

  18. Molecular control of irreversible bistability during trypanosome developmental commitment

    PubMed Central

    Domingo-Sananes, Maria Rosa; Szöőr, Balazs; Ferguson, Michael A.J.

    2015-01-01

    The life cycle of Trypanosoma brucei involves developmental transitions that allow survival, proliferation, and transmission of these parasites. One of these, the differentiation of growth-arrested stumpy forms in the mammalian blood into insect-stage procyclic forms, can be induced synchronously in vitro with cis-aconitate. Here, we show that this transition is an irreversible bistable switch, and we map the point of commitment to differentiation after exposure to cis-aconitate. This irreversibility implies that positive feedback mechanisms operate to allow commitment (i.e., the establishment of “memory” of exposure to the differentiation signal). Using the reversible translational inhibitor cycloheximide, we show that this signal memory requires new protein synthesis. We further performed stable isotope labeling by amino acids in cell culture to analyze synchronized parasite populations, establishing the protein and phosphorylation profile of parasites pre- and postcommitment, thereby defining the “commitment proteome.” Functional interrogation of this data set identified Nek-related kinase as the first-discovered protein kinase controlling the initiation of differentiation to procyclic forms. PMID:26483558

  19. Optical bistability with film-coupled metasurfaces.

    PubMed

    Huang, Zhiqin; Baron, Alexandre; Larouche, Stéphane; Argyropoulos, Christos; Smith, David R

    2015-12-01

    Metasurfaces comprising arrays of film-coupled, nanopatch antennas are a promising platform for low-energy, all-optical switches. The large field enhancements that can be achieved in the dielectric spacer region between the nanopatch and the metallic substrate can substantially enhance optical nonlinear processes. Here we consider a dielectric material that exhibits an optical Kerr effect as the spacer layer and numerically calculate the optical bistability of a metasurface using the finite element method (FEM). We expect the proposed method to be highly accurate compared with other numerical approaches, such as those based on graphical post-processing techniques, because it self-consistently solves for both the spatial field distribution and the intensity-dependent refractive index distribution of the spacer layer. This method offers an alternative approach to finite-difference time-domain (FDTD) modeling. We use this numerical tool to design a metasurface optical switch and our optimized design exhibits exceptionally low switching intensity of 33  kW/cm2, corresponding to switching energy on the order of tens of attojoules per resonator, a value much smaller than those found for most devices reported in the literature. We propose our method as a tool for designing all-optical switches and modulators.

  20. Conductance bistability in metal oxide junctions

    NASA Astrophysics Data System (ADS)

    Tan, Zhongkui; Patel, Vijay; Monge, Esteban; Chang, Shih-Sheng; Pottorf, Shawn; Lukens, James; Likharev, Konstantin

    2009-03-01

    We are exploring conductance bistability (memory) effects in junctions based on metal oxides, in the context of their possible applications in hybrid CMOS/nanoelectronic (e.g., CMOL [1]) circuits. So far, we have investigated CuOx, NbOx and TiOx formed by thermal and plasma oxidation, with or without rapid thermal post-annealing (at 200 to 800^oC for 30 to 300 seconds). Conductance switching effects have been observed for all these materials. Particularly high endurance (over 1000 switching cycles) has been obtained for TiOx junctions plasma oxidized in 15mTorr oxygen and then post-annealed at 700^oC. However, the ON/OFF conductance ratio for these junctions is only about 5, and the sample-to-sample reproducibility is much lower than required for integrated circuit applications. Our plans are to extend our studies to a-Si junctions with one Ag electrode, and multilayer TiOx junctions, with the main goal to improve device reproducibility. The work is supported in part by AFOSR. [3pt] [1] K. K. Likharev, ``Hybrid CMOS/Nanoelectronic Circuits,'' accepted for publication in J. Nanoelectronics and Optoelectronics, Nov. 2008.

  1. Epigenetic chromatin silencing: bistability and front propagation

    NASA Astrophysics Data System (ADS)

    Sedighi, Mohammad; Sengupta, Anirvan M.

    2007-12-01

    The role of post-translational modification of histones in eukaryotic gene regulation is well recognized. Epigenetic silencing of genes via heritable chromatin modifications plays a major role in cell fate specification in higher organisms. We formulate a coarse-grained model of chromatin silencing in yeast and study the conditions under which the system becomes bistable, allowing for different epigenetic states. We also study the dynamics of the boundary between the two locally stable states of chromatin: silenced and unsilenced. The model could be of use in guiding the discussion on chromatin silencing in general. In the context of silencing in budding yeast, it helps us understand the phenotype of various mutants, some of which may be non-trivial to see without the help of a mathematical model. One such example is a mutation that reduces the rate of background acetylation of particular histone side chains that competes with the deacetylation by Sir2p. The resulting negative feedback due to a Sir protein depletion effect gives rise to interesting counter-intuitive consequences. Our mathematical analysis brings forth the different dynamical behaviors possible within the same molecular model and guides the formulation of more refined hypotheses that could be addressed experimentally.

  2. Epigenetic chromatin silencing: bistability and front propagation

    PubMed Central

    Sedighi, Mohammad; Sengupta, Anirvan M

    2008-01-01

    The role of post-translational modification of histones in eukaryotic gene regulation is well recognized. Epigenetic silencing of genes via heritable chromatin modifications plays a major role in cell fate specification in higher organisms. We formulate a coarse-grained model of chromatin silencing in yeast and study the conditions under which the system becomes bistable, allowing for different epigenetic states. We also study the dynamics of the boundary between the two locally stable states of chromatin: silenced and unsilenced. The model could be of use in guiding the discussion on chromatin silencing in general. In the context of silencing in budding yeast, it helps us understand the phenotype of various mutants, some of which may be non-trivial to see without the help of a mathematical model. One such example is a mutation that reduces the rate of background acetylation of particular histone side chains that competes with the deacetylation by Sir2p. The resulting negative feedback due to a Sir protein depletion effect gives rise to interesting counter-intuitive consequences. Our mathematical analysis brings forth the different dynamical behaviors possible within the same molecular model and guides the formulation of more refined hypotheses that could be addressed experimentally. PMID:17991991

  3. An analytical study on bistability of Fabry-Perot semiconductor optical amplifiers

    NASA Astrophysics Data System (ADS)

    Wang, Gang; Chen, Shuqiang; Yang, Huajun

    2016-09-01

    Optical bistabilities have been considered to be useful for sensor applications. As a typical nonlinear device, Fabry-Perot semiconductor optical amplifiers (FPSOAs) exhibit bistability under certain conditions. In this paper, the bistable characteristics in FPSOAs are investigated theoretically. Based on Adams's relationship between the incident optical intensity I in and the z-independent average intracavity intensity I av, an analytical expression of the bistable loop width in SOAs is derived. Numerical simulations confirm the accuracy of the analytical result.

  4. Non-resonant energy harvesting via an adaptive bistable potential

    NASA Astrophysics Data System (ADS)

    Haji Hosseinloo, Ashkan; Turitsyn, Konstantin

    2016-01-01

    Narrow bandwidth and easy detuning, inefficiency in broadband and non-stationary excitations, and difficulties in matching a linear harvester’s resonance frequency to low-frequency excitations at small scales, have convinced researchers to investigate nonlinear, and in particular bistable, energy harvesters in recent years. However, bistable harvesters suffer from co-existing low and high energy orbits, and sensitivity to initial conditions, and have recently been proven inefficient when subjected to many real-world random and non-stationary excitations. Here, we propose a novel non-resonant buy-low-sell-high strategy that can significantly improve the harvester’s effectiveness at low frequencies in a much more robust fashion. This strategy could be realized by a passive adaptive bistable system. Simulation results confirm the high effectiveness of the adaptive bistable system following a buy-low-sell-high logic when subjected to harmonic and random non-stationary walking excitations compared to its conventional bistable and linear counterparts.

  5. Oscillations in the bistable regime of neuronal networks

    NASA Astrophysics Data System (ADS)

    Roxin, Alex; Compte, Albert

    2016-07-01

    Bistability between attracting fixed points in neuronal networks has been hypothesized to underlie persistent activity observed in several cortical areas during working memory tasks. In network models this kind of bistability arises due to strong recurrent excitation, sufficient to generate a state of high activity created in a saddle-node (SN) bifurcation. On the other hand, canonical network models of excitatory and inhibitory neurons (E-I networks) robustly produce oscillatory states via a Hopf (H) bifurcation due to the E-I loop. This mechanism for generating oscillations has been invoked to explain the emergence of brain rhythms in the β to γ bands. Although both bistability and oscillatory activity have been intensively studied in network models, there has not been much focus on the coincidence of the two. Here we show that when oscillations emerge in E-I networks in the bistable regime, their phenomenology can be explained to a large extent by considering coincident SN and H bifurcations, known as a codimension two Takens-Bogdanov bifurcation. In particular, we find that such oscillations are not composed of a stable limit cycle, but rather are due to noise-driven oscillatory fluctuations. Furthermore, oscillations in the bistable regime can, in principle, have arbitrarily low frequency.

  6. Fundamental role of bistability in optimal homeostatic control

    NASA Astrophysics Data System (ADS)

    Wang, Guanyu

    2013-03-01

    Bistability is a fundamental phenomenon in nature and has a number of fine properties. However, these properties are consequences of bistability at the physiological level, which do not explain why it had to emerge during evolution. Using optimal homeostasis as the first principle and Pontryagin's Maximum Principle as the optimization approach, I find that bistability emerges as an indispensable control mechanism. Because the mathematical model is general and the result is independent of parameters, it is likely that most biological systems use bistability to control homeostasis. Glucose homeostasis represents a good example. It turns out that bistability is the only solution to a dilemma in glucose homeostasis: high insulin efficiency is required for rapid plasma glucose clearance, whereas an insulin sparing state is required to guarantee the brain's safety during fasting. This new perspective can illuminate studies on the twin epidemics of obesity and diabetes and the corresponding intervening strategies. For example, overnutrition and sedentary lifestyle may represent sudden environmental changes that cause the lose of optimality, which may contribute to the marked rise of obesity and diabetes in our generation.

  7. Bistability of mangrove forests and competition with freshwater plants

    USGS Publications Warehouse

    Jiang, Jiang; Fuller, Douglas O; Teh, Su Yean; Zhai, Lu; Koh, Hock Lye; DeAngelis, Donald L.; Sternberg, L.D.S.L.

    2015-01-01

    Halophytic communities such as mangrove forests and buttonwood hammocks tend to border freshwater plant communities as sharp ecotones. Most studies attribute this purely to underlying physical templates, such as groundwater salinity gradients caused by tidal flux and topography. However, a few recent studies hypothesize that self-reinforcing feedback between vegetation and vadose zone salinity are also involved and create a bistable situation in which either halophytic dominated habitat or freshwater plant communities may dominate as alternative stable states. Here, we revisit the bistability hypothesis and demonstrate the mechanisms that result in bistability. We demonstrate with remote sensing imagery the sharp boundaries between freshwater hardwood hammock communities in southern Florida and halophytic communities such as buttonwood hammocks and mangroves. We further document from the literature how transpiration of mangroves and freshwater plants respond differently to vadose zone salinity, thus altering the salinity through feedback. Using mathematical models, we show how the self-reinforcing feedback, together with physical template, controls the ecotones between halophytic and freshwater communities. Regions of bistability along environmental gradients of salinity have the potential for large-scale vegetation shifts following pulse disturbances such as hurricane tidal surges in Florida, or tsunamis in other regions. The size of the region of bistability can be large for low-lying coastal habitat due to the saline water table, which extends inland due to salinity intrusion. We suggest coupling ecological and hydrologic processes as a framework for future studies.

  8. Oscillations in the bistable regime of neuronal networks.

    PubMed

    Roxin, Alex; Compte, Albert

    2016-07-01

    Bistability between attracting fixed points in neuronal networks has been hypothesized to underlie persistent activity observed in several cortical areas during working memory tasks. In network models this kind of bistability arises due to strong recurrent excitation, sufficient to generate a state of high activity created in a saddle-node (SN) bifurcation. On the other hand, canonical network models of excitatory and inhibitory neurons (E-I networks) robustly produce oscillatory states via a Hopf (H) bifurcation due to the E-I loop. This mechanism for generating oscillations has been invoked to explain the emergence of brain rhythms in the β to γ bands. Although both bistability and oscillatory activity have been intensively studied in network models, there has not been much focus on the coincidence of the two. Here we show that when oscillations emerge in E-I networks in the bistable regime, their phenomenology can be explained to a large extent by considering coincident SN and H bifurcations, known as a codimension two Takens-Bogdanov bifurcation. In particular, we find that such oscillations are not composed of a stable limit cycle, but rather are due to noise-driven oscillatory fluctuations. Furthermore, oscillations in the bistable regime can, in principle, have arbitrarily low frequency. PMID:27575167

  9. Bistable property of a flexible ring in a uniform flow

    NASA Astrophysics Data System (ADS)

    Kim, Bo Young; Shin, Soo Jai; Sung, Hyung Jin

    2011-11-01

    An improved version of the immersed boundary (IB) method is developed for simulating a flexible ring clamped at one point in a uniform flow. The boundary of the ring consists of a flexible filament with tension and bending stiffness, which can be modeled as a linear spring with spring constant k and initially unstretched length. In our simulation, we observe bistable states, one stationary stable and the other self-sustained periodically flapping, that coexist over a range of flow velocities depending on the initial inclination angle. The bistable property of the initially elliptic flexible ring is observed in the simulations. The Reynolds number range of the bistability region and the flapping amplitude are specified for various aspect ratios (a/b). It is found that for a/b = 0.5, the bistability region is most postponed and the flapping amplitude at the self-sustained flapping state is minimized. A new bistability phenomenon is observed that with certain aspect ratio two periodically flapping states coexist with different amplitudes in a Reynolds number range, instead of the stationary stable and periodically flapping states. This study was supported by the Creative Research Initiatives of NRF/MEST (No. 2011-0000423) of Korea.

  10. Oscillations in the bistable regime of neuronal networks.

    PubMed

    Roxin, Alex; Compte, Albert

    2016-07-01

    Bistability between attracting fixed points in neuronal networks has been hypothesized to underlie persistent activity observed in several cortical areas during working memory tasks. In network models this kind of bistability arises due to strong recurrent excitation, sufficient to generate a state of high activity created in a saddle-node (SN) bifurcation. On the other hand, canonical network models of excitatory and inhibitory neurons (E-I networks) robustly produce oscillatory states via a Hopf (H) bifurcation due to the E-I loop. This mechanism for generating oscillations has been invoked to explain the emergence of brain rhythms in the β to γ bands. Although both bistability and oscillatory activity have been intensively studied in network models, there has not been much focus on the coincidence of the two. Here we show that when oscillations emerge in E-I networks in the bistable regime, their phenomenology can be explained to a large extent by considering coincident SN and H bifurcations, known as a codimension two Takens-Bogdanov bifurcation. In particular, we find that such oscillations are not composed of a stable limit cycle, but rather are due to noise-driven oscillatory fluctuations. Furthermore, oscillations in the bistable regime can, in principle, have arbitrarily low frequency.

  11. Metrology of Non-Rigid Objects

    SciTech Connect

    Blaedel, K L; Smith, D W; Claudet, A A; Kasper, E P; Patterson, S R

    2002-01-01

    Dimensional characterization of non-rigid parts presents many challenges. For example, when a non-rigid part is mounted in an inspection apparatus the effects of fixturing constraints cause significant deformation of the part. If the part is not used in normal service with the same load conditions as during inspection, the dimensional characteristics in service will deviate from the reported values during inspection. Further, the solution of designing specialized fixturing to duplicate ''as-installed'' conditions does not fully resolve the problem because each inspection requires its own methodology. The goal of this project is to formulate the research problem and propose a method of assessing the dimensional characteristics of non-rigid parts. The measured dimension of a rigid component is traceable at some level of confidence to a single source (NIST in the USA). Hence the measurement of one component of an assembly can be related to the measurement of another component of that assembly. There is no generalized analog to this pedigreed process for dimensionally characterizing non-rigid bodies. For example, a measurement made on a sheet-metal automobile fender is heavily influenced by how it is held during the measurement making it difficult to determine how well that fender will assemble to the rest of the (non-rigid) car body. This problem is often overcome for specific manufacturing problems by constructing rigid fixtures that over-constrain the non-rigid parts to be assembled and then performing the dimensional measurement of the contour of each component to check whether each meets specification. Note that such inspection measurements will yield only an approximation to the assembled shape, which is a function of both the geometry and the compliance of the component parts of the assembly. As a result, non-rigid components are more difficult to specify and inspect and therefore are more difficult to purchase from outside vendors compared to rigid components

  12. Rigid porous filter

    DOEpatents

    Chiang, Ta-Kuan; Straub, Douglas L.; Dennis, Richard A.

    2000-01-01

    The present invention involves a porous rigid filter including a plurality of concentric filtration elements having internal flow passages and forming external flow passages there between. The present invention also involves a pressure vessel containing the filter for the removal of particulates from high pressure particulate containing gases, and further involves a method for using the filter to remove such particulates. The present filter has the advantage of requiring fewer filter elements due to the high surface area-to-volume ratio provided by the filter, requires a reduced pressure vessel size, and exhibits enhanced mechanical design properties, improved cleaning properties, configuration options, modularity and ease of fabrication.

  13. Optical bistability: A novel approach to optical signal processing and communications

    NASA Technical Reports Server (NTRS)

    Peyghambarian, N.

    1984-01-01

    Optical bistability and its potential for optical signal processing and communications are reviewed. Recent experimental results in semiconductor optical bistability are presented. In particular, optical bistability in GaAs-AlGaAs superlattices and CuCl, ZnS, and ZnSe is discussed.

  14. Working cycles of devices based on bistable carbon nanotubes

    NASA Astrophysics Data System (ADS)

    Shklyaev, Oleg; Mockensturm, Eric; Crespi, Vincent; Carbon Nanotubes Collaboration

    2013-03-01

    Shape-changing nanotubes are an example of variable-shape sp2 carbon-based systems where the competition between strain and surface energies can be moderated by an externally controllable stimuli such as applied voltage, temperature, or pressure of gas encapsulated inside the tube. Using any of these stimuli one can transition a bistable carbon nanotube between the collapsed and inflated states and thus perform mechanical work. During the working cycle of such a device, energy from an electric or heat source is transferred to mechanical energy. Combinations of these stimuli allow the system to convert energy between different sources using the bistable shape-changing tube as a mediator. For example, coupling a bistable carbon nanotube to the heat and charge reservoirs can enable energy transfer between heat and electric forms. The developed theory can be extended to other nano-systems which change configurations in response to external stimuli.

  15. Optical bistability in erbium-doped yttrium aluminum garnet crystal combined with a laser diode.

    PubMed

    Maeda, Y

    1994-01-10

    Optical bistability was observed in a simple structure of an injection laser diode combined with an erbium-doped yttrium aluminum garnet crystal. Since a hysteresis characteristic exists in the relationship between the wavelength and the injection current of a laser diode, an optical memory function capable of holding the output status is confirmed. In addition, an optical signal inversion was caused by the decrease of transmission of the erbium-doped yttrium aluminum garnet crystal against the red shift (principally mode hopping) of the laser diode. It is suggested that the switching time of this phenomenon is the time necessary for a mode hopping by current injection.

  16. Magnetic bistability in a submonolayer of sublimated Fe4 single-molecule magnets.

    PubMed

    Malavolti, Luigi; Lanzilotto, Valeria; Ninova, Silviya; Poggini, Lorenzo; Cimatti, Irene; Cortigiani, Brunetto; Margheriti, Ludovica; Chiappe, Daniele; Otero, Edwige; Sainctavit, Philippe; Totti, Federico; Cornia, Andrea; Mannini, Matteo; Sessoli, Roberta

    2015-01-14

    We demonstrate that Fe4 molecules can be deposited on gold by thermal sublimation in ultra-high vacuum with retention of single molecule magnet behavior. A magnetic hysteresis comparable to that found in bulk samples is indeed observed when a submonolayer film is studied by X-ray magnetic circular dichroism. Scanning tunneling microscopy evidences that Fe4 molecules are assembled in a two-dimensional lattice with short-range hexagonal order and coexist with a smaller contaminant. The presence of intact Fe4 molecules and the retention of their bistable magnetic behavior on the gold surface are supported by density functional theory calculations.

  17. The geodynamo as a bistable oscillator

    NASA Astrophysics Data System (ADS)

    Hoyng, P.; Ossendrijver, M. A. J. H.; Schmitt, D.

    2001-07-01

    Our intent is to provide a simple and quantitative understanding of the variability of the axial dipole component of the geomagnetic field on both short and long time scales. To this end we study the statistical properties of a prototype nonlinear mean field model. An azimuthal average is employed, so that (1) we address only the axisymmetric component of the field, and (2) the dynamo parameters have a random component that fluctuates on the (fast) eddy turnover time scale. Numerical solutions with a rapidly fluctuating alpha reproduce several features of the geomagnetic field: (1) a variable, dominantly dipolar field with additional fine structure due to excited overtones, and sudden reversals during which the field becomes almost quadrupolar, (2) aborted reversals and excursions, (3) intervals between reversals having a Poisson distribution. These properties are robust, and appear regardless of the type of nonlinearity and the model parameters. A technique is presented for analysing the statistical properties of dynamo models of this type. The Fokker-Planck equation for the amplitude a of the fundamental dipole mode shows that a behaves as the position of a heavily damped particle in a bistable potential ~(1-a^2)^2, subject to random forcing. The dipole amplitude oscillates near the bottom of one well and makes occasional jumps to the other. These reversals are induced solely by the overtones. Theoretical expressions are derived for the statistical distribution of the dipole amplitude, the variance of the dipole amplitude between reversals, and the mean reversal rate. The model explains why the reversal rate increases with increasing secular variation, as observed. Moreover, the present reversal rate of the geodynamo, once per (2-3)x10^5years, is shown to imply a secular variation of the dipole moment of ~15% (about the current value). The theoretical dipole amplitude distribution agrees well with the Sint-800 data.

  18. Thermodielectric bistability in dual frequency nematic liquid crystal.

    PubMed

    Yin, Y; Shiyanovskii, S V; Lavrentovich, O D

    2007-03-01

    We report on a thermodielectric bistability in dual frequency nematic liquid crystals (LCs) caused by the anisotropic nature of dielectric heating and director reorientation in an electric field. The bistability is a result of the positive feedback loop: director reorientation --> anisotropic dielectric heating --> dielectric anisotrophy --> director reorientation. We demonstrate both experimentally and theoretically that two states with different temperature and director orientation, namely, a cold planar state and a hot homeotropic state coexist in a LC cell for a certain frequency and amplitude range of the applied voltage.

  19. New organic bistable films for ultrafast electric memories

    NASA Astrophysics Data System (ADS)

    Hua, Z. Y.; Chen, G. R.; Xu, W.; Chen, D. Y.

    2001-01-01

    Thin films which have electrical bistable effects are mostly metal-organic complexes and/or organic-organic (all-organic) complexes. Very recently some simple (mono-molecular) organic materials have been discovered which have bistable states at room temperature, too. The threshold voltage across these organic films with a thickness of 60 nm is 4-6 V and the transition time is 5-10 ns. Therefore, they are suitable to make ultrafast, non-volatile, organic memories (WORM or EPROM). Another possible application for an STM type ultrahigh-capacity memory is also illustrated.

  20. Thermodielectric Bistability in Dual Frequency Nematic Liquid Crystal

    NASA Astrophysics Data System (ADS)

    Yin, Y.; Shiyanovskii, S. V.; Lavrentovich, O. D.

    2007-03-01

    We report on a thermodielectric bistability in dual frequency nematic liquid crystals (LCs) caused by the anisotropic nature of dielectric heating and director reorientation in an electric field. The bistability is a result of the positive feedback loop: director reorientation → anisotropic dielectric heating → dielectric anisotrophy → director reorientation. We demonstrate both experimentally and theoretically that two states with different temperature and director orientation, namely, a cold planar state and a hot homeotropic state coexist in a LC cell for a certain frequency and amplitude range of the applied voltage.

  1. Graphene-controlled fiber Bragg grating and enabled optical bistability.

    PubMed

    Gan, Xuetao; Wang, Yadong; Zhang, Fanlu; Zhao, Chenyang; Jiang, Biqiang; Fang, Liang; Li, Dongying; Wu, Hao; Ren, Zhaoyu; Zhao, Jianlin

    2016-02-01

    We report a graphene-assisted all-optical control of a fiber Bragg grating (FBG), which enables in-fiber optical bistability and switching. With an optical pump, a micro-FBG wrapped by graphene evolves into chirped and phase-shifted FBGs, whose characteristic wavelengths and bandwidths could be controlled by the pump power. Optical bistability and multistability are achieved in the controlled FBG based on a shifted Bragg reflection or Fabry-Perot-type resonance, which allow the implementation of optical switching with an extinction ratio exceeding 20 dB and a response time in tens of milliseconds. PMID:26907434

  2. Bistable moving optical solitons in resonant photonic crystals

    SciTech Connect

    Vlasov, R. A.; Lemeza, A. M.

    2011-08-15

    We consider some new aspects of the formation of moving optical solitons in a medium of Bragg-type resonant grating doped with two-level atoms. For generality, account is taken of the local-field effect assisted by a sufficiently high density of resonant atoms. It is established analytically that there exists a family of soliton solutions to the two-wave Maxwell-Bloch system of equations, with these solitons exhibiting bistable properties. The existence of bistable solitons and their properties are confirmed by numerical simulations.

  3. Wavelength demodulation of fiber grating sensors using hybrid optical bistability

    NASA Astrophysics Data System (ADS)

    Lv, Guohui; Ou, Jinping; Wang, Huiying; Jiang, Xu; Shang, Shaohua

    2007-07-01

    In this article, a novel approach for demodulation of fiber grating sensors with high resolution is proposed based on a hybrid fiber optical bistablity device (OBD). This OBD is consisted of a FFP ring-cavity laser, fiber Bragg grating (FBG) and a certain optoelectronic feedback circuit. The optical bistability can be realized through alternative the center wavelength of the tunable fiber laser when the output power of the laser is fixed. The Bragg wavelength of sensing grating is determined by the switching on voltage of OBD.

  4. Thermodielectric bistability in dual frequency nematic liquid crystal.

    PubMed

    Yin, Y; Shiyanovskii, S V; Lavrentovich, O D

    2007-03-01

    We report on a thermodielectric bistability in dual frequency nematic liquid crystals (LCs) caused by the anisotropic nature of dielectric heating and director reorientation in an electric field. The bistability is a result of the positive feedback loop: director reorientation --> anisotropic dielectric heating --> dielectric anisotrophy --> director reorientation. We demonstrate both experimentally and theoretically that two states with different temperature and director orientation, namely, a cold planar state and a hot homeotropic state coexist in a LC cell for a certain frequency and amplitude range of the applied voltage. PMID:17359197

  5. Improved Accuracy in RNA-Protein Rigid Body Docking by Incorporating Force Field for Molecular Dynamics Simulation into the Scoring Function.

    PubMed

    Iwakiri, Junichi; Hamada, Michiaki; Asai, Kiyoshi; Kameda, Tomoshi

    2016-09-13

    RNA-protein interactions play fundamental roles in many biological processes. To understand these interactions, it is necessary to know the three-dimensional structures of RNA-protein complexes. However, determining the tertiary structure of these complexes is often difficult, suggesting that an accurate rigid body docking for RNA-protein complexes is needed. In general, the rigid body docking process is divided into two steps: generating candidate structures from the individual RNA and protein structures and then narrowing down the candidates. In this study, we focus on the former problem to improve the prediction accuracy in RNA-protein docking. Our method is based on the integration of physicochemical information about RNA into ZDOCK, which is known as one of the most successful computer programs for protein-protein docking. Because recent studies showed the current force field for molecular dynamics simulation of protein and nucleic acids is quite accurate, we modeled the physicochemical information about RNA by force fields such as AMBER and CHARMM. A comprehensive benchmark of RNA-protein docking, using three recently developed data sets, reveals the remarkable prediction accuracy of the proposed method compared with existing programs for docking: the highest success rate is 34.7% for the predicted structure of the RNA-protein complex with the best score and 79.2% for 3,600 predicted ones. Three full atomistic force fields for RNA (AMBER94, AMBER99, and CHARMM22) produced almost the same accurate result, which showed current force fields for nucleic acids are quite accurate. In addition, we found that the electrostatic interaction and the representation of shape complementary between protein and RNA plays the important roles for accurate prediction of the native structures of RNA-protein complexes.

  6. Improved Accuracy in RNA-Protein Rigid Body Docking by Incorporating Force Field for Molecular Dynamics Simulation into the Scoring Function.

    PubMed

    Iwakiri, Junichi; Hamada, Michiaki; Asai, Kiyoshi; Kameda, Tomoshi

    2016-09-13

    RNA-protein interactions play fundamental roles in many biological processes. To understand these interactions, it is necessary to know the three-dimensional structures of RNA-protein complexes. However, determining the tertiary structure of these complexes is often difficult, suggesting that an accurate rigid body docking for RNA-protein complexes is needed. In general, the rigid body docking process is divided into two steps: generating candidate structures from the individual RNA and protein structures and then narrowing down the candidates. In this study, we focus on the former problem to improve the prediction accuracy in RNA-protein docking. Our method is based on the integration of physicochemical information about RNA into ZDOCK, which is known as one of the most successful computer programs for protein-protein docking. Because recent studies showed the current force field for molecular dynamics simulation of protein and nucleic acids is quite accurate, we modeled the physicochemical information about RNA by force fields such as AMBER and CHARMM. A comprehensive benchmark of RNA-protein docking, using three recently developed data sets, reveals the remarkable prediction accuracy of the proposed method compared with existing programs for docking: the highest success rate is 34.7% for the predicted structure of the RNA-protein complex with the best score and 79.2% for 3,600 predicted ones. Three full atomistic force fields for RNA (AMBER94, AMBER99, and CHARMM22) produced almost the same accurate result, which showed current force fields for nucleic acids are quite accurate. In addition, we found that the electrostatic interaction and the representation of shape complementary between protein and RNA plays the important roles for accurate prediction of the native structures of RNA-protein complexes. PMID:27494732

  7. Generalized flexibility-rigidity index

    NASA Astrophysics Data System (ADS)

    Nguyen, Duc Duy; Xia, Kelin; Wei, Guo-Wei

    2016-06-01

    Flexibility-rigidity index (FRI) has been developed as a robust, accurate, and efficient method for macromolecular thermal fluctuation analysis and B-factor prediction. The performance of FRI depends on its formulations of rigidity index and flexibility index. In this work, we introduce alternative rigidity and flexibility formulations. The structure of the classic Gaussian surface is utilized to construct a new type of rigidity index, which leads to a new class of rigidity densities with the classic Gaussian surface as a special case. Additionally, we introduce a new type of flexibility index based on the domain indicator property of normalized rigidity density. These generalized FRI (gFRI) methods have been extensively validated by the B-factor predictions of 364 proteins. Significantly outperforming the classic Gaussian network model, gFRI is a new generation of methodologies for accurate, robust, and efficient analysis of protein flexibility and fluctuation. Finally, gFRI based molecular surface generation and flexibility visualization are demonstrated.

  8. Fractal rigidity in migraine

    NASA Astrophysics Data System (ADS)

    Latka, Miroslaw; Glaubic-Latka, Marta; Latka, Dariusz; West, Bruce J.

    2004-04-01

    We study the middle cerebral artery blood flow velocity (MCAfv) in humans using transcranial Doppler ultrasonography (TCD). Scaling properties of time series of the axial flow velocity averaged over a cardiac beat interval may be characterized by two exponents. The short time scaling exponent (STSE) determines the statistical properties of fluctuations of blood flow velocities in short-time intervals while the Hurst exponent describes the long-term fractal properties. In many migraineurs the value of the STSE is significantly reduced and may approach that of the Hurst exponent. This change in dynamical properties reflects the significant loss of short-term adaptability and the overall hyperexcitability of the underlying cerebral blood flow control system. We call this effect fractal rigidity.

  9. Rigid collapsible dish structure

    NASA Technical Reports Server (NTRS)

    Palmer, William B. (Inventor); Giebler, Martin M. (Inventor)

    1982-01-01

    A collapsible dish structure composed of a plurality of rows of rigid radial petal assemblies concentric with the axis of the dish. The petal assemblies consist of a center petal and two side petals, the center petal hinged on an axis tangent to a circle concentric with the axis of the dish and the side petals hinged to the center petal at their mating edge. The center petal is foldable inwardly and the side petals rotate about their hinges such that the collapsed dish structure occupies a much smaller volume than the deployed dish. Means of controlling the shape of the dish to compensate for differential expansion of the deployed dish are also provided.

  10. Neural substrates of perceptual integration during bistable object perception

    PubMed Central

    Flevaris, Anastasia V.; Martínez, Antigona; Hillyard, Steven A.

    2013-01-01

    The way we perceive an object depends both on feedforward, bottom-up processing of its physical stimulus properties and on top-down factors such as attention, context, expectation, and task relevance. Here we compared neural activity elicited by varying perceptions of the same physical image—a bistable moving image in which perception spontaneously alternates between dissociated fragments and a single, unified object. A time-frequency analysis of EEG changes associated with the perceptual switch from object to fragment and vice versa revealed a greater decrease in alpha (8–12 Hz) accompanying the switch to object percept than to fragment percept. Recordings of event-related potentials elicited by irrelevant probes superimposed on the moving image revealed an enhanced positivity between 184 and 212 ms when the probes were contained within the boundaries of the perceived unitary object. The topography of the positivity (P2) in this latency range elicited by probes during object perception was distinct from the topography elicited by probes during fragment perception, suggesting that the neural processing of probes differed as a function of perceptual state. Two source localization algorithms estimated the neural generator of this object-related difference to lie in the lateral occipital cortex, a region long associated with object perception. These data suggest that perceived objects attract attention, incorporate visual elements occurring within their boundaries into unified object representations, and enhance the visual processing of elements occurring within their boundaries. Importantly, the perceived object in this case emerged as a function of the fluctuating perceptual state of the viewer. PMID:24246467

  11. In silico evolved lac operons exhibit bistability for artificial inducers, but not for lactose.

    PubMed

    van Hoek, M J A; Hogeweg, P

    2006-10-15

    Bistability in the lac operon of Escherichia coli has been widely studied, both experimentally and theoretically. Experimentally, bistability has been observed when E. coli is induced by an artificial, nonmetabolizable, inducer. However, if the lac operon is induced with lactose, the natural inducer, bistability has not been demonstrated. We derive an analytical expression that can predict the occurrence of bistability both for artificial inducers and lactose. We find very different conditions for bistability in the two cases. Indeed, for artificial inducers bistability is predicted, but for lactose the condition for bistability is much more difficult to satisfy. Moreover, we demonstrate that in silico evolution of the lac operon generates an operon that avoids bistability with respect to lactose, but does exhibit bistability with respect to artificial inducers. The activity of this evolved operon strikingly resembles the experimentally observed activity of the operon. Thus our computational experiments suggest that the wild-type lac operon, which regulates lactose metabolism, is not a bistable switch. Nevertheless, for engineering purposes, this operon can be used as a bistable switch with artificial inducers. PMID:16877514

  12. Stochastic analysis of bistability in coherent mixed feedback loops combining transcriptional and posttranscriptional regulations

    NASA Astrophysics Data System (ADS)

    Nitzan, Mor; Shimoni, Yishai; Rosolio, Oded; Margalit, Hanah; Biham, Ofer

    2015-05-01

    Mixed feedback loops combining transcriptional and posttranscriptional regulations are common in cellular regulatory networks. They consist of two genes, encoding a transcription factor and a small noncoding RNA (sRNA), which mutually regulate each other's expression. We present a theoretical and numerical study of coherent mixed feedback loops of this type, in which both regulations are negative. Under suitable conditions, these feedback loops are expected to exhibit bistability, namely, two stable states, one dominated by the transcriptional repressor and the other dominated by the sRNA. We use deterministic methods based on rate equation models, in order to identify the range of parameters in which bistability takes place. However, the deterministic models do not account for the finite lifetimes of the bistable states and the spontaneous, fluctuation-driven transitions between them. Therefore, we use stochastic methods to calculate the average lifetimes of the two states. It is found that these lifetimes strongly depend on rate coefficients such as the transcription rates of the transcriptional repressor and the sRNA. In particular, we show that the fraction of time the system spends in the sRNA-dominated state follows a monotonically decreasing sigmoid function of the transcriptional repressor transcription rate. The biological relevance of these results is discussed in the context of such mixed feedback loops in Escherichia coli. It is shown that the fluctuation-driven transitions and the dependence of some rate coefficients on the biological conditions enable the cells to switch to the state which is better suited for the existing conditions and to remain in that state as long as these conditions persist.

  13. Confirmation of bistable stellar differential rotation profiles

    NASA Astrophysics Data System (ADS)

    Käpylä, P. J.; Käpylä, M. J.; Brandenburg, A.

    2014-10-01

    Context. Solar-like differential rotation is characterized by a rapidly rotating equator and slower poles. However, theoretical models and numerical simulations can also result in a slower equator and faster poles when the overall rotation is slow. Aims: We study the critical rotational influence under which differential rotation flips from solar-like (fast equator, slow poles) to an anti-solar one (slow equator, fast poles). We also estimate the non-diffusive (Λ effect) and diffusive (turbulent viscosity) contributions to the Reynolds stress. Methods: We present the results of three-dimensional numerical simulations of mildly turbulent convection in spherical wedge geometry. Here we apply a fully compressible setup which would suffer from a prohibitive time step constraint if the real solar luminosity was used. To avoid this problem while still representing the same rotational influence on the flow as in the Sun, we increase the luminosity by a factor of roughly 106 and the rotation rate by a factor of 102. We regulate the convective velocities by varying the amount of heat transported by thermal conduction, turbulent diffusion, and resolved convection. Results: Increasing the efficiency of resolved convection leads to a reduction of the rotational influence on the flow and a sharp transition from solar-like to anti-solar differential rotation for Coriolis numbers around 1.3. We confirm the recent finding of a large-scale flow bistability: contrasted with running the models from an initial condition with unprescribed differential rotation, the initialization of the model with certain kind of rotation profile sustains the solution over a wider parameter range. The anti-solar profiles are found to be more stable against perturbations in the level of convective turbulent velocity than the solar-type solutions. Conclusions: Our results may have implications for real stars that start their lives as rapid rotators implying solar-like rotation in the early main

  14. Non-volatile, solid state bistable electrical switch

    NASA Technical Reports Server (NTRS)

    Williams, Roger M. (Inventor)

    1994-01-01

    A bistable switching element is made of a material whose electrical resistance reversibly decreases in response to intercalation by positive ions. Flow of positive ions between the bistable switching element and a positive ion source is controlled by means of an electrical potential applied across a thermal switching element. The material of the thermal switching element generates heat in response to electrical current flow therethrough, which in turn causes the material to undergo a thermal phase transition from a high electrical resistance state to a low electrical resistance state as the temperature increases above a predetermined value. Application of the electrical potential in one direction renders the thermal switching element conductive to pass electron current out of the ion source. This causes positive ions to flow from the source into the bistable switching element and intercalate the same to produce a non-volatile, low resistance logic state. Application of the electrical potential in the opposite direction causes reverse current flow which de-intercalates the bistable logic switching element and produces a high resistance logic state.

  15. Origin of bistability underlying mammalian cell cycle entry.

    PubMed

    Yao, Guang; Tan, Cheemeng; West, Mike; Nevins, Joseph R; You, Lingchong

    2011-04-26

    Precise control of cell proliferation is fundamental to tissue homeostasis and differentiation. Mammalian cells commit to proliferation at the restriction point (R-point). It has long been recognized that the R-point is tightly regulated by the Rb-E2F signaling pathway. Our recent work has further demonstrated that this regulation is mediated by a bistable switch mechanism. Nevertheless, the essential regulatory features in the Rb-E2F pathway that create this switching property have not been defined. Here we analyzed a library of gene circuits comprising all possible link combinations in a simplified Rb-E2F network. We identified a minimal circuit that is able to generate robust, resettable bistability. This minimal circuit contains a feed-forward loop coupled with a mutual-inhibition feedback loop, which forms an AND-gate control of the E2F activation. Underscoring its importance, experimental disruption of this circuit abolishes maintenance of the activated E2F state, supporting its importance for the bistability of the Rb-E2F system. Our findings suggested basic design principles for the robust control of the bistable cell cycle entry at the R-point. PMID:21525871

  16. Origin of bistability underlying mammalian cell cycle entry

    PubMed Central

    Yao, Guang; Tan, Cheemeng; West, Mike; Nevins, Joseph R; You, Lingchong

    2011-01-01

    Precise control of cell proliferation is fundamental to tissue homeostasis and differentiation. Mammalian cells commit to proliferation at the restriction point (R-point). It has long been recognized that the R-point is tightly regulated by the Rb–E2F signaling pathway. Our recent work has further demonstrated that this regulation is mediated by a bistable switch mechanism. Nevertheless, the essential regulatory features in the Rb–E2F pathway that create this switching property have not been defined. Here we analyzed a library of gene circuits comprising all possible link combinations in a simplified Rb–E2F network. We identified a minimal circuit that is able to generate robust, resettable bistability. This minimal circuit contains a feed-forward loop coupled with a mutual-inhibition feedback loop, which forms an AND-gate control of the E2F activation. Underscoring its importance, experimental disruption of this circuit abolishes maintenance of the activated E2F state, supporting its importance for the bistability of the Rb–E2F system. Our findings suggested basic design principles for the robust control of the bistable cell cycle entry at the R-point. PMID:21525871

  17. Advances in GaAs bistable optical devices

    NASA Astrophysics Data System (ADS)

    Jewell, J. L.; Tarng, S. S.; Gibbs, H. M.; Tai, K.; Weinberger, D. A.; Gossard, A. C.; McCall, S. L.; Passner, A.; Venkatesan, T. N. C.; Weigmann, W.

    1984-01-01

    Bistable optical devices (BOD's) using GaAs as the nonlinear medium are viable candidators for the achievement of fast ( ns), room temperature, low-power (mw), externally controllable optical switches which are easily fabricated and operated. Advances were made in all of these areas and efforts are in progress to improve performances in ways that are simultaneously compatible.

  18. Bistability in the chemical master equation for dual phosphorylation cycles.

    PubMed

    Bazzani, Armando; Castellani, Gastone C; Giampieri, Enrico; Remondini, Daniel; Cooper, Leon N

    2012-06-21

    Dual phospho/dephosphorylation cycles, as well as covalent enzymatic-catalyzed modifications of substrates are widely diffused within cellular systems and are crucial for the control of complex responses such as learning, memory, and cellular fate determination. Despite the large body of deterministic studies and the increasing work aimed at elucidating the effect of noise in such systems, some aspects remain unclear. Here we study the stationary distribution provided by the two-dimensional chemical master equation for a well-known model of a two step phospho/dephosphorylation cycle using the quasi-steady state approximation of enzymatic kinetics. Our aim is to analyze the role of fluctuations and the molecules distribution properties in the transition to a bistable regime. When detailed balance conditions are satisfied it is possible to compute equilibrium distributions in a closed and explicit form. When detailed balance is not satisfied, the stationary non-equilibrium state is strongly influenced by the chemical fluxes. In the last case, we show how the external field derived from the generation and recombination transition rates, can be decomposed by the Helmholtz theorem, into a conservative and a rotational (irreversible) part. Moreover, this decomposition allows to compute the stationary distribution via a perturbative approach. For a finite number of molecules there exists diffusion dynamics in a macroscopic region of the state space where a relevant transition rate between the two critical points is observed. Further, the stationary distribution function can be approximated by the solution of a Fokker-Planck equation. We illustrate the theoretical results using several numerical simulations.

  19. Bistability in the chemical master equation for dual phosphorylation cycles

    NASA Astrophysics Data System (ADS)

    Bazzani, Armando; Castellani, Gastone C.; Giampieri, Enrico; Remondini, Daniel; Cooper, Leon N.

    2012-06-01

    Dual phospho/dephosphorylation cycles, as well as covalent enzymatic-catalyzed modifications of substrates are widely diffused within cellular systems and are crucial for the control of complex responses such as learning, memory, and cellular fate determination. Despite the large body of deterministic studies and the increasing work aimed at elucidating the effect of noise in such systems, some aspects remain unclear. Here we study the stationary distribution provided by the two-dimensional chemical master equation for a well-known model of a two step phospho/dephosphorylation cycle using the quasi-steady state approximation of enzymatic kinetics. Our aim is to analyze the role of fluctuations and the molecules distribution properties in the transition to a bistable regime. When detailed balance conditions are satisfied it is possible to compute equilibrium distributions in a closed and explicit form. When detailed balance is not satisfied, the stationary non-equilibrium state is strongly influenced by the chemical fluxes. In the last case, we show how the external field derived from the generation and recombination transition rates, can be decomposed by the Helmholtz theorem, into a conservative and a rotational (irreversible) part. Moreover, this decomposition allows to compute the stationary distribution via a perturbative approach. For a finite number of molecules there exists diffusion dynamics in a macroscopic region of the state space where a relevant transition rate between the two critical points is observed. Further, the stationary distribution function can be approximated by the solution of a Fokker-Planck equation. We illustrate the theoretical results using several numerical simulations.

  20. Electrically conductive rigid polyurethane foam

    DOEpatents

    Neet, T.E.; Spieker, D.A.

    1983-12-08

    A rigid, moldable polyurethane foam comprises about 2 to 10 weight percent, based on the total foam weight, of a carbon black which is CONDUCTEX CC-40-220 or CONDUCTEX SC, whereby the rigid polyurethane foam is electrically conductive and has essentially the same mechanical properties as the same foam without carbon black added.

  1. Electrically conductive rigid polyurethane foam

    DOEpatents

    Neet, Thomas E.; Spieker, David A.

    1985-03-19

    A rigid, polyurethane foam comprises about 2-10 weight percent, based on the total foam weight, of a carbon black which is CONDUCTEX CC-40-220 or CONDUCTEX SC, whereby the rigid polyurethane foam is electrically conductive and has essentially the same mechanical properties as the same foam without carbon black added.

  2. miR-155 regulates differentiation of brown and beige adipocytes via a bistable circuit

    PubMed Central

    Chen, Yong; Siegel, Franziska; Kipschull, Stefanie; Haas, Bodo; Fröhlich, Holger; Meister, Gunter; Pfeifer, Alexander

    2013-01-01

    Brown adipocytes are a primary site of energy expenditure and reside not only in classical brown adipose tissue but can also be found in white adipose tissue. Here we show that microRNA 155 is enriched in brown adipose tissue and is highly expressed in proliferating brown preadipocytes but declines after induction of differentiation. Interestingly, microRNA 155 and its target, the adipogenic transcription factor CCAAT/enhancer-binding protein β, form a bistable feedback loop integrating hormonal signals that regulate proliferation or differentiation. Inhibition of microRNA 155 enhances brown adipocyte differentiation and induces a brown adipocyte-like phenotype (‘browning’) in white adipocytes. Consequently, microRNA 155-deficient mice exhibit increased brown adipose tissue function and ‘browning’ of white fat tissue. In contrast, transgenic overexpression of microRNA 155 in mice causes a reduction of brown adipose tissue mass and impairment of brown adipose tissue function. These data demonstrate that the bistable loop involving microRNA 155 and CCAAT/enhancer-binding protein β regulates brown lineage commitment, thereby, controlling the development of brown and beige fat cells. PMID:23612310

  3. On the Hα behaviour of blue supergiants: rise and fall over the bi-stability jump

    NASA Astrophysics Data System (ADS)

    Petrov, Blagovest; Vink, Jorick S.; Gräfener, Götz

    2014-05-01

    Context. The evolutionary state of blue supergiants is still unknown. Stellar wind mass loss is one of the dominant processes determining the evolution of massive stars, and it may provide clues to the evolutionary properties of blue supergiants. As the Hα line is the most oft-used mass-loss tracer in the OB-star regime, we investigate Hα line formation as a function of Teff. Aims: We provide a detailed analysis of the Hα line for OB supergiant models over an Teff range between 30 000 and 12 500 K, with the aim of understanding the mass-loss properties of blue supergiants. Methods: We model the Hα line using the non-LTE code cmfgen, in the context of the bi-stability jump at Teff ~ 22 500 K. Results: We find a maximum in the Hα equivalent width at 22 500 K exactly at the location of the bi-stability jump. The Hα line-profile behaviour is characterised by two branches of effective temperature: (i) a hot branch between 30 000 and 22 500 K, where Hα emission becomes stronger with decreasing Teff; and (ii) a cool branch between 22 500 and 12 500 K, where the Hα line becomes weaker. Our models show that this non-monotonic Hα behaviour is related to the optical depth of Lyα, finding that at the "cool" branch the population of the 2nd level of hydrogen is enhanced in comparison to the 3rd level. This is expected to increase line absorption, leading to weaker Hα flux when Teff drops from 22 500 K downwards. We also show that for late B supergiants (at Teff below ~15 000 K), the differences in the Hα line between homogeneous and clumpy winds becomes insignificant. Moreover, we show that, at the bi-stability jump, Hα changes its character completely, from an optically thin to an optically thick line, implying that macro-clumping should play an important role at temperatures below the bi-stability jump. This would not only have consequences for the character of observed Hα line profiles, but also for the reported discrepancies between theoretical and empirical

  4. Tree cover bistability in the MPI Earth system model due to fire-vegetation feedback

    NASA Astrophysics Data System (ADS)

    Lasslop, Gitta; Brovkin, Victor; Kloster, Silvia; Reick, Christian

    2015-04-01

    The global distribution of tree cover is mainly limited by precipitation and temperature. Within tropical ecosystems different tree cover values have been observed in regions with similar climate. Satellite data even revealed a lack of ecosystems with tree coverage around 60% and dominant tree covers of 20% and 80%. Conceptual models have been used to explain this tree cover distribution and base it on a bistability in tree cover caused by fire-vegetation interactions or competition between trees and grasses. Some ecological models also show this property of multiple stable tree covers, but it remains unclear which mechanism is the cause for this behaviour. Vegetation models used in climate simulations usually use simple approaches and were criticised to neglect such ecological theories and misrepresent tropical tree cover distribution and dynamics. Here we show that including the process based fire model SPITFIRE generated a bistability in tree cover in the land surface model JSBACH. Previous model versions showed only one stable tree cover state. Using a conceptual model we can show that a bistability can occur due to a feedback between grasses and fire. Grasses and trees are represented in the model based on plant functional types. With respect to fire the main difference between grasses and trees is the fuel characteristics. Grass fuels are smaller in size, and have a higher surface area to volume ratio. These grass fuels dry faster increasing their flammability which leads to a higher fire rate of spread. Trees are characterized by coarse fuels, which are less likely to ignite and rather suppress fire. Therefore a higher fraction of grasses promotes fire, fire kills trees and following a fire, grasses establish faster. This feedback can stabilize ecosystems with low tree cover in a low tree cover state and systems with high tree cover in a high tree cover state. In previous model versions this feedback was absent. Based on the new JSBACH model driven with

  5. Bistable dynamics of a levitated nanoparticle (Presentation Recording)

    NASA Astrophysics Data System (ADS)

    Ricci, Francesco; Spasenovic, M.; Rica, Raúl A.; Novotny, Lukas; Quidant, Romain

    2015-08-01

    Bistable systems are ubiquitous in nature. Classical examples in chemistry and biology include relaxation kinetics in chemical reactions [1] and stochastic resonance processes such as neuron firing [2,3]. Likewise, bistable systems play a key role in signal processing and information handling at the nanoscale, giving rise to intriguing applications such as optical switches [4], coherent signal amplification [5,6] and weak forces detection [5]. The interest and applicability of bistable systems are intimately connected with the complexity of their dynamics, typically due to the presence of a large number of parameters and nonlinearities. Appropriate modeling is therefore challenging. Alternatively, the possibility to experimentally recreate bistable systems in a clean and controlled way has recently become very appealing, but elusive and complicated. With this aim, we combined optical tweezers with a novel active feedback-cooling scheme to develop a well-defined opto-mechanical platform reaching unprecedented performances in terms of Q-factor, frequency stability and force sensitivity [7,8]. Our experimental system consists of a single nanoparticle levitated in high vacuum with optical tweezers, which behaves as a non-linear (Duffing) oscillator under appropriate conditions. Here, we prove it to be an ideal tool for a deep study of bistability. We demonstrate bistability of the nanoparticle by noise activated switching between two oscillation states, discussing our results in terms of a double-well potential model. We also show the flexibility of our system in shaping the potential at will, in order to meet the conditions prescribed by any bistable system that could therefore then be simulated with our setup. References [1] T. Amemiya, T. Ohmori, M. Nakaiwa, T. Yamamoto, and T. Yamaguchi, "Modeling of Nonlinear Chemical Reaction Systems and Two-Parameter Stochastic Resonance," J. Biol. Phys. 25 (1999) 73 [2] F. Moss, L. M. Ward, and W. G. Sannita, "Stochastic

  6. Optical and electrical manipulation of a single bi-stable Si-atom in GaAs

    NASA Astrophysics Data System (ADS)

    Koenraad, Paul; Smakman, Erwin

    2014-03-01

    We will show that a Si atom in the outermost layer of GaAs has a bi-stable character much alike the well-known DX-center in AlxGa1-xAs. In the ground state the Si atom is negatively charged and in the excited metastable state it is positively charged. These two charge states are related to a modification of the bond configuration of the Si atom in the GaAs surface layer. The voltage dependence of this bi-stable character can be used to bring the Si atom in either of the two states while probing it with an STM tip. The electrical excitation and relaxation processes were studied by analyzing the current and voltage dependence of the observed Random Telegraph Noise. We have successfully used this to create a memory element based on a single impurity atom. Our low T STM setup allows to illuminate the tunneling area and/or to collect tunneling induced photons from the area below the STM tip. We will show our recent results with the optical manipulation of the bond configuration and corresponding charge state of a single bi-stable Si atom as a function of the excitation wavelength (E.P. Smakman et al. PRB 87 085414 (2013)). This allowed us to unravel different pathways for the excitation and relaxation processes that are involved in this optical manipulation.

  7. Bistability of self-modulation of the GaAs intrinsic stimulated picosecond radiation spectrum

    SciTech Connect

    Ageeva, N. N.; Bronevoi, I. L. Zabegaev, D. N.; Krivonosov, A. N.

    2013-08-15

    The bistability of self-modulation of the spectrum of the stimulated picosecond radiation that appears during picosecond optical pumping of GaAs is detected. The radiation is measured before it reaches the end faces of a sample. One set of equidistant modes occurs in the radiation spectrum at the radiation pulse front. A set of modes located at the center between the initial modes replaces the first set in the descending radiation branch. The intermode interval inside each set coincides with the calculated interval between the eigenmodes of the GaAs layer, which is an active cavity. The radiation rise time turns out to be an oscillating function of the photon energy. The spectrum evolution is self-consistent so that the time-integrated spectrum and the spectrum-integrated radiation pulse envelope have a smooth (without local singularities) shape. The revealed bistability explains the physical nature of the two radiation-induced states of population depletion between which subterahertz self-oscillations in the radiation field were detected earlier. The radiation spectrum self-modulation is assumed to be a variant of stimulated Raman scattering.

  8. Confinement and diffusion modulate bistability and stochastic switching in a reaction network with positive feedback

    NASA Astrophysics Data System (ADS)

    Mlynarczyk, Paul J.; Pullen, Robert H.; Abel, Steven M.

    2016-01-01

    Positive feedback is a common feature in signal transduction networks and can lead to phenomena such as bistability and signal propagation by domain growth. Physical features of the cellular environment, such as spatial confinement and the mobility of proteins, play important but inadequately understood roles in shaping the behavior of signaling networks. Here, we use stochastic, spatially resolved kinetic Monte Carlo simulations to explore a positive feedback network as a function of system size, system shape, and mobility of molecules. We show that these physical properties can markedly alter characteristics of bistability and stochastic switching when compared with well-mixed simulations. Notably, systems of equal volume but different shapes can exhibit qualitatively different behaviors under otherwise identical conditions. We show that stochastic switching to a state maintained by positive feedback occurs by cluster formation and growth. Additionally, the frequency at which switching occurs depends nontrivially on the diffusion coefficient, which can promote or suppress switching relative to the well-mixed limit. Taken together, the results provide a framework for understanding how confinement and protein mobility influence emergent features of the positive feedback network by modulating molecular concentrations, diffusion-influenced rate parameters, and spatiotemporal correlations between molecules.

  9. Confinement and diffusion modulate bistability and stochastic switching in a reaction network with positive feedback.

    PubMed

    Mlynarczyk, Paul J; Pullen, Robert H; Abel, Steven M

    2016-01-01

    Positive feedback is a common feature in signal transduction networks and can lead to phenomena such as bistability and signal propagation by domain growth. Physical features of the cellular environment, such as spatial confinement and the mobility of proteins, play important but inadequately understood roles in shaping the behavior of signaling networks. Here, we use stochastic, spatially resolved kinetic Monte Carlo simulations to explore a positive feedback network as a function of system size, system shape, and mobility of molecules. We show that these physical properties can markedly alter characteristics of bistability and stochastic switching when compared with well-mixed simulations. Notably, systems of equal volume but different shapes can exhibit qualitatively different behaviors under otherwise identical conditions. We show that stochastic switching to a state maintained by positive feedback occurs by cluster formation and growth. Additionally, the frequency at which switching occurs depends nontrivially on the diffusion coefficient, which can promote or suppress switching relative to the well-mixed limit. Taken together, the results provide a framework for understanding how confinement and protein mobility influence emergent features of the positive feedback network by modulating molecular concentrations, diffusion-influenced rate parameters, and spatiotemporal correlations between molecules.

  10. Construction of an in vitro bistable circuit from synthetic transcriptional switches

    PubMed Central

    Kim, Jongmin; White, Kristin S; Winfree, Erik

    2006-01-01

    Information processing using biochemical circuits is essential for survival and reproduction of natural organisms. As stripped-down analogs of genetic regulatory networks in cells, we engineered artificial transcriptional networks consisting of synthetic DNA switches, regulated by RNA signals acting as transcription repressors, and two enzymes, bacteriophage T7 RNA polymerase and Escherichia coli ribonuclease H. The synthetic switch design is modular with programmable connectivity and allows dynamic control of RNA signals through enzyme-mediated production and degradation. The switches support sharp and adjustable thresholds using a competitive hybridization mechanism, allowing arbitrary analog or digital circuits to be created in principle. As an example, we constructed an in vitro bistable memory by wiring together two synthetic switches and performed a systematic quantitative characterization. Good agreement between experimental data and a simple mathematical model was obtained for switch input/output functions, phase plane trajectories, and the bifurcation diagram for bistability. Construction of larger synthetic circuits provides a unique opportunity for evaluating model inference, prediction, and design of complex biochemical systems and could be used to control nanoscale devices and artificial cells. PMID:17170763

  11. [Parkinsonian rigidity: clinical and physiopathologic aspects].

    PubMed

    Delwaide, P J; Pepin, J L; Maertens de Noordhout, A

    1990-01-01

    Neurophysiologic mechanisms responsible for parkinsonian rigidity are poorly understood. In any case, they have to fit all the clinical data which are first reviewed before discussing 2 theories which are proposed to interpret rigidity. The first theory postulates that increased resistance to mobilization is due to hyperactivity in a long loop reflex pathway which originates at the neuromuscular spindles and relays in the motor cortex. This theory is based on the largely accepted finding that, in parkinsonian patients, M2 response is increased when a voluntary movement is abruptly stopped. Although popular this hypothesis is far from explaining all the clinical facts, namely that rigidity is equal in extensor and flexor, proximal and distal muscles. Based on a reflex set by primary afferent discharges, it is incompatible with the lack of rigidity reinforcement after faster passive mobilization. The second theory rests on data obtained from electrophysiological studies of some spinal interneurones. Both IA and IB inhibitory interneurones are functionally modified but not in the same direction. While the IA inhibitory interneurone is facilitated, the IB inhibitory interneurone is less active. Disappearance of autogenic inhibition can explain rigidity at rest and the tonic stretch reflex. In addition, interneurones intervening in the flexor reflex disclose a modified excitability. It is possible to interpret these facts by postulating an abnormal influence transmitted through descending reticulospinal pathways. This abnormal influence would result from modified activation of reticular nuclei by afferents projecting from the basal ganglia. Such a hypothesis is open to experimental testing through the startle reaction. The latter facilitates the H reflex by the reticulospinal pathways, the influence of cortex--if any--being negligible.(ABSTRACT TRUNCATED AT 250 WORDS)

  12. Effects of pacing magnitudes and forms on bistability width in a modeled ventricular tissue

    NASA Astrophysics Data System (ADS)

    Huang, Xiaodong; Liu, Xuemei; Zheng, Lixian; Mi, Yuanyuan; Qian, Yu

    2013-07-01

    Bistability in periodically paced cardiac tissue is relevant to cardiac arrhythmias and its control. In the present paper, one-dimensional tissue of the phase I Luo-Rudy model is numerically investigated. The effects of various parameters of pacing signals on bistability width are studied. The following conclusions are obtained: (i) Pacing can be classified into two types: pulsatile and sinusoidal types. Pulsatile pacing reduces bistability width as its magnitude is increased. Sinusoidal pacing increases the width as its amplitude is increased. (ii) In a pacing period the hyperpolarizing part plays a more important role than the depolarizing part. Variations of the hyperpolarizing ratio in a period evidently change the width of bistability and its variation tendency. (iii) A dynamical mechanism is proposed to qualitatively explain the phenomena, which reveals the reason for the different effects of pulsatile and sinusoidal pacing on bistability. The methods for changing bistability width by external pacing may help control arrhythmias in cardiology.

  13. Optical bistability in plasmonic nanoparticles: Effect of size, shape and embedding medium

    NASA Astrophysics Data System (ADS)

    Daneshfar, Nader; Foroughi, Hamidreza

    2016-09-01

    We theoretically investigate the optical bistability, which one input signal allows two possible outputs, from single spherical/cylindrical nanoparticles and also nanoshells in the frame work of quasi-static formalism. It is shown that the bistability behavior greatly depends on several parameters such as the nanoparticle size, material and the surrounding dielectric environment. We demonstrated the width of the bistability region and also the bistable threshold depends on the geometrical parameters, and can be tuned by adjusting the size of nanoparticle, the shell thickness and the dielectric constant of the embedding medium. It is also shown that the optical bistable behavior depends strongly on the shape of plasmonic nanoparticles and nanoshells. However, these dependences of optical bistability of spherical/cylindrical nanoparticles and nanoshells on changing of their geometrical parameters can be used for realize optical switching and sensing purposes.

  14. Bistability of the naturally induced lactose utilization system of Escherichia coli

    NASA Astrophysics Data System (ADS)

    Stajic, Jelena; Wall, Michael

    2006-03-01

    In the absence of the preferred sugar glucose, lactose utilization machinery in the bacterium E. coli is activated. The genetic circuit responsible for this response, lac operon, has been observed to exhibit bistability when induced by an artificial inducer, TMG. Here we investigate conditions under which bistability might be observed in response to lactose. The aim of our study is to establish whether the natural system exhibits bistability, as is often assumed despite the lack of experimental support.

  15. Inhibitory interactions promote frequent bistability among competing bacteria.

    PubMed

    Wright, Erik S; Vetsigian, Kalin H

    2016-01-01

    It is largely unknown how the process of microbial community assembly is affected by the order of species arrival, initial species abundances and interactions between species. A minimal way of capturing competitive abilities in a frequency-dependent manner is with an invasibility network specifying whether a species at low abundance can increase in frequency in an environment dominated by another species. Here, using a panel of prolific small-molecule producers and a habitat with feast-and-famine cycles, we show that the most abundant strain can often exclude other strains--resulting in bistability between pairs of strains. Instead of a single winner, the empirically determined invasibility network is ruled by multiple strains that cannot invade each other, and does not contain loops of cyclic dominance. Antibiotic inhibition contributes to bistability by helping producers resist invasions while at high abundance and by reducing producers' ability to invade when at low abundance. PMID:27097658

  16. Intrinsic optical bistability in a strongly driven Rydberg ensemble

    NASA Astrophysics Data System (ADS)

    de Melo, Natalia R.; Wade, Christopher G.; Šibalić, Nikola; Kondo, Jorge M.; Adams, Charles S.; Weatherill, Kevin J.

    2016-06-01

    We observe and characterize intrinsic optical bistability in a dilute Rydberg vapor. The bistability is characterized by sharp jumps between states of low and high Rydberg occupancy with jump-up and -down positions displaying hysteresis depending on the direction in which the control parameter is changed. We find that the shift in frequency of the jump point scales with the fourth power of the principal quantum number. Also, the width of the hysteresis window increases with increasing principal quantum number, before reaching a peak and then closing again. The experimental results are consistent with predictions from a simple theoretical model based on semiclassical Maxwell-Bloch equations including the effects of interaction-induced broadening and level shifts. These results provide insight into the dynamics of driven dissipative systems.

  17. Bistable dark solitons of a cubic-quintic Helmholtz equation

    SciTech Connect

    Christian, J. M.; McDonald, G. S.; Chamorro-Posada, P.

    2010-05-15

    We provide a report on exact analytical bistable dark spatial solitons of a nonlinear Helmholtz equation with a cubic-quintic refractive-index model. Our analysis begins with an investigation of the modulational instability characteristics of Helmholtz plane waves. We then derive a dark soliton by mapping the desired asymptotic form onto a uniform background field and obtain a more general solution by deploying rotational invariance laws in the laboratory frame. The geometry of the new soliton is explored in detail, and a range of new physical predictions is uncovered. Particular attention is paid to the unified phenomena of arbitrary-angle off-axis propagation and nondegenerate bistability. Crucially, the corresponding solution of paraxial theory emerges in a simultaneous multiple limit. We conclude with a set of computer simulations that examine the role of Helmholtz dark solitons as robust attractors.

  18. Bistable salt doped cholesteric liquid crystals light shutter

    NASA Astrophysics Data System (ADS)

    Moheghi, Alireza; Nemati, Hossein; Li, Yannian; Li, Quan; Yang, Deng-Ke

    2016-02-01

    Liquid crystals have been used to make electrically switchable light shutters (windows), but most of them are monostable: opaque in the absence of applied voltage and transparent when a voltage is applied. Here we report a bistable switchable light shutter based on cholesteric liquid crystal doped with tetrabutylammonium bromide. The salt makes it possible for the liquid crystal to have different electro-optical responses to applied voltages with different frequencies. The shutter can be either transparent or opaque in the absence of applied voltage. It can be switched from the transparent state to the opaque state by applying a low frequency (60 Hz) voltage pulse and switched back to the transparent state by applying a high frequency (2 kHz) voltage pulse. Because of the bistability, it can be used for energy-saving switchable privacy control and architectural windows.

  19. Optical bistability in a silicon nitride waveguide grating

    NASA Astrophysics Data System (ADS)

    Bej, Subhajit; Laukkanen, Janne; Tervo, Jani; Svirko, Yuri P.; Turunen, Jari

    2016-04-01

    Using the Fourier Modal Method for gratings with Kerr media [J. Opt. Soc. Am. B 31, 2371 (2014)] we demonstrate that low energy Optical Bistability for normally incident light field can be observed by strong nonlinear light-matter interactions in a Silicon Nitride waveguide-grating with 2-D periodicity. Finite divergence of the incident light beam has been taken into account in our numerical study and the gratings are designed to observe bistable behavior in direct transmitted light inside the optical telecommunication C-band (1520 nm-1570 nm). The waveguide grating structures are fabricated from PECVD synthesized Silicon Nitride thin film on top of quartz with standard electron beam lithography and reactive ion etching techniques. We aim to demonstrate this phenomenon experimentally using a tunable narrow line-width pulsed laser. Our resonant nanostructures may find applications in free space all-optical information processing and all-optical switching.

  20. Inhibitory interactions promote frequent bistability among competing bacteria

    PubMed Central

    Wright, Erik S.; Vetsigian, Kalin H.

    2016-01-01

    It is largely unknown how the process of microbial community assembly is affected by the order of species arrival, initial species abundances and interactions between species. A minimal way of capturing competitive abilities in a frequency-dependent manner is with an invasibility network specifying whether a species at low abundance can increase in frequency in an environment dominated by another species. Here, using a panel of prolific small-molecule producers and a habitat with feast-and-famine cycles, we show that the most abundant strain can often exclude other strains—resulting in bistability between pairs of strains. Instead of a single winner, the empirically determined invasibility network is ruled by multiple strains that cannot invade each other, and does not contain loops of cyclic dominance. Antibiotic inhibition contributes to bistability by helping producers resist invasions while at high abundance and by reducing producers' ability to invade when at low abundance. PMID:27097658

  1. Optical bistability in photonic crystal microrings with nonlinear dielectric materials.

    PubMed

    Ogusu, Kazuhiko; Takayama, Kosuke

    2008-05-12

    We study the linear resonance properties of several types of microrings in a two-dimensional photonic crystal (PC) consisting of a square lattice with air holes in dielectric using the plane-wave expansion method and the FDTD method. Moreover we investigate the nonlinear responses, especially optical bistability when an intense optical pulse is incident into the microrings. In this paper, Ag-As-Se chalcogenide glass is assumed as nonlinear dielectric, which has a high third-order nonlinearity. Although line-defect waveguides in an air-hole-type PC are usually multimoded, we can obtain interesting unique properties such as counter rotation of intracavity fields, transmission to all output ports, and unstable nonlinear oscillations in the multimoded PC microring. We can improve the resonance characteristics by partly introducing single-mode waveguides into microrings and can obtain stable optical bistability.

  2. Emergent bistability by a growth-modulating positive feedback circuit.

    PubMed

    Tan, Cheemeng; Marguet, Philippe; You, Lingchong

    2009-11-01

    Synthetic gene circuits are often engineered by considering the host cell as an invariable 'chassis'. Circuit activation, however, may modulate host physiology, which in turn can substantially impact circuit behavior. We illustrate this point by a simple circuit consisting of mutant T7 RNA polymerase (T7 RNAP*) that activates its own expression in the bacterium Escherichia coli. Although activation by the T7 RNAP* is noncooperative, the circuit caused bistable gene expression. This counterintuitive observation can be explained by growth retardation caused by circuit activation, which resulted in nonlinear dilution of T7 RNAP* in individual bacteria. Predictions made by models accounting for such effects were verified by further experimental measurements. Our results reveal a new mechanism of generating bistability and underscore the need to account for host physiology modulation when engineering gene circuits.

  3. Experimental study of resistive bistability in metal oxide junctions

    NASA Astrophysics Data System (ADS)

    Tan, Zhongkui; Patel, Vijay; Likharev, Konstantin K.; Su, Dong; Zhu, Yimei

    2011-05-01

    We have studied resistive bistability (memory) effects in junctions based on metal oxides, with a focus on sample-to-sample reproducibility, which is necessary for the use of such junctions as crosspoint devices of hybrid CMOS/nanoelectronic circuits. Few-nm-thick layers of NbO x , CuO x and TiO x have been formed by thermal and plasma oxidation, at various deposition and oxidation conditions, both with and without rapid thermal post-annealing. The resistive bistability effect has been observed for all these materials, with particularly high endurance (over 103 switching cycles) obtained for single-layer TiO2 junctions, and the best reproducibility reached for multi-layer junctions of the same material. Fabrication optimization has allowed us to improve the OFF/ON resistance ratio to about 103, but the sample-to-sample reproducibility is so far lower than that required for large-scale integration.

  4. Autocatalytic, bistable, oscillatory networks of biologically relevant organic reactions.

    PubMed

    Semenov, Sergey N; Kraft, Lewis J; Ainla, Alar; Zhao, Mengxia; Baghbanzadeh, Mostafa; Campbell, Victoria E; Kang, Kyungtae; Fox, Jerome M; Whitesides, George M

    2016-09-28

    Networks of organic chemical reactions are important in life and probably played a central part in its origin. Network dynamics regulate cell division, circadian rhythms, nerve impulses and chemotaxis, and guide the development of organisms. Although out-of-equilibrium networks of chemical reactions have the potential to display emergent network dynamics such as spontaneous pattern formation, bistability and periodic oscillations, the principles that enable networks of organic reactions to develop complex behaviours are incompletely understood. Here we describe a network of biologically relevant organic reactions (amide formation, thiolate-thioester exchange, thiolate-disulfide interchange and conjugate addition) that displays bistability and oscillations in the concentrations of organic thiols and amides. Oscillations arise from the interaction between three subcomponents of the network: an autocatalytic cycle that generates thiols and amides from thioesters and dialkyl disulfides; a trigger that controls autocatalytic growth; and inhibitory processes that remove activating thiol species that are produced during the autocatalytic cycle. In contrast to previous studies that have demonstrated oscillations and bistability using highly evolved biomolecules (enzymes and DNA) or inorganic molecules of questionable biochemical relevance (for example, those used in Belousov-Zhabotinskii-type reactions), the organic molecules we use are relevant to metabolism and similar to those that might have existed on the early Earth. By using small organic molecules to build a network of organic reactions with autocatalytic, bistable and oscillatory behaviour, we identify principles that explain the ways in which dynamic networks relevant to life could have developed. Modifications of this network will clarify the influence of molecular structure on the dynamics of reaction networks, and may enable the design of biomimetic networks and of synthetic self-regulating and evolving

  5. Bistability in dual-frequency nematic liquid crystals

    NASA Astrophysics Data System (ADS)

    Palto, S. P.; Barnik, M. I.

    2007-03-01

    Different modes of bistable switching in liquid crystals with frequency inversion of the dielectric anisotropy sign are discussed. The study is performed by numerical simulation and experimentally. It is shown that dual frequency driving can be effectively used to control switching between topologically equivalent and non-equivalent director field distributions. The experimental results on temperature performance of the dual-frequency switching and possible driving methods for energy consumption and expanding the temperature range are presented.

  6. Autocatalytic, bistable, oscillatory networks of biologically relevant organic reactions

    NASA Astrophysics Data System (ADS)

    Semenov, Sergey N.; Kraft, Lewis J.; Ainla, Alar; Zhao, Mengxia; Baghbanzadeh, Mostafa; Campbell, Victoria E.; Kang, Kyungtae; Fox, Jerome M.; Whitesides, George M.

    2016-09-01

    Networks of organic chemical reactions are important in life and probably played a central part in its origin. Network dynamics regulate cell division, circadian rhythms, nerve impulses and chemotaxis, and guide the development of organisms. Although out-of-equilibrium networks of chemical reactions have the potential to display emergent network dynamics such as spontaneous pattern formation, bistability and periodic oscillations, the principles that enable networks of organic reactions to develop complex behaviours are incompletely understood. Here we describe a network of biologically relevant organic reactions (amide formation, thiolate-thioester exchange, thiolate-disulfide interchange and conjugate addition) that displays bistability and oscillations in the concentrations of organic thiols and amides. Oscillations arise from the interaction between three subcomponents of the network: an autocatalytic cycle that generates thiols and amides from thioesters and dialkyl disulfides; a trigger that controls autocatalytic growth; and inhibitory processes that remove activating thiol species that are produced during the autocatalytic cycle. In contrast to previous studies that have demonstrated oscillations and bistability using highly evolved biomolecules (enzymes and DNA) or inorganic molecules of questionable biochemical relevance (for example, those used in Belousov-Zhabotinskii-type reactions), the organic molecules we use are relevant to metabolism and similar to those that might have existed on the early Earth. By using small organic molecules to build a network of organic reactions with autocatalytic, bistable and oscillatory behaviour, we identify principles that explain the ways in which dynamic networks relevant to life could have developed. Modifications of this network will clarify the influence of molecular structure on the dynamics of reaction networks, and may enable the design of biomimetic networks and of synthetic self-regulating and evolving

  7. Renormalized transport equations for the bistable potential model

    NASA Astrophysics Data System (ADS)

    Weidlich, Wolfgang; Grabert, Hermann

    1980-09-01

    Renormalized transport equations for general Fokker-Planck systems are derived and applied to the bistable potential model. The exact equation for the expectation value < x> t can be evaluated in both domains < D>∈ x ± and < x>∈ D 0 outside and between the potential minima, leading to drastic differences of the dynamics prevailing in D ± and D 0, respectively.

  8. Autocatalytic, bistable, oscillatory networks of biologically relevant organic reactions.

    PubMed

    Semenov, Sergey N; Kraft, Lewis J; Ainla, Alar; Zhao, Mengxia; Baghbanzadeh, Mostafa; Campbell, Victoria E; Kang, Kyungtae; Fox, Jerome M; Whitesides, George M

    2016-01-01

    Networks of organic chemical reactions are important in life and probably played a central part in its origin. Network dynamics regulate cell division, circadian rhythms, nerve impulses and chemotaxis, and guide the development of organisms. Although out-of-equilibrium networks of chemical reactions have the potential to display emergent network dynamics such as spontaneous pattern formation, bistability and periodic oscillations, the principles that enable networks of organic reactions to develop complex behaviours are incompletely understood. Here we describe a network of biologically relevant organic reactions (amide formation, thiolate-thioester exchange, thiolate-disulfide interchange and conjugate addition) that displays bistability and oscillations in the concentrations of organic thiols and amides. Oscillations arise from the interaction between three subcomponents of the network: an autocatalytic cycle that generates thiols and amides from thioesters and dialkyl disulfides; a trigger that controls autocatalytic growth; and inhibitory processes that remove activating thiol species that are produced during the autocatalytic cycle. In contrast to previous studies that have demonstrated oscillations and bistability using highly evolved biomolecules (enzymes and DNA) or inorganic molecules of questionable biochemical relevance (for example, those used in Belousov-Zhabotinskii-type reactions), the organic molecules we use are relevant to metabolism and similar to those that might have existed on the early Earth. By using small organic molecules to build a network of organic reactions with autocatalytic, bistable and oscillatory behaviour, we identify principles that explain the ways in which dynamic networks relevant to life could have developed. Modifications of this network will clarify the influence of molecular structure on the dynamics of reaction networks, and may enable the design of biomimetic networks and of synthetic self-regulating and evolving

  9. Nanoparticle-induced negative differential resistance and memory effect in polymer bistable light-emitting device

    NASA Astrophysics Data System (ADS)

    Tseng, Ricky J.; Ouyang, Jianyong; Chu, Chih-Wei; Huang, Jinsong; Yang, Yang

    2006-03-01

    Recently, electrical bistability was demonstrated in polymer thin films incorporated with metal nanoparticles [J. Ouyang, C. W. Chu, C. R. Szmanda, L. P. Ma, and Y. Yang, Nat. Mater. 3, 918 (2004)]. In this letter, we show the evidence that electrons are the dominant charge carriers in these bistable devices. Direct integration of bistable polymer layer with a light-emitting polymer layer shows a unique light-emitting property modulated by the electrical bistability. A unique negative differential resistance induced by the charged gold nanoparticles is observed due to the charge trapping effect from the nanoparticles when interfaced with the light-emitting layer.

  10. Controllable optical bistability and multistability in asymmetric double quantum wells via spontaneously generated coherence

    SciTech Connect

    Chen, Yuan; Deng, Li; Chen, Aixi

    2015-02-15

    We investigate the nonlinear optical phenomena of the optical bistability and multistability via spontaneously generated coherence in an asymmetric double quantum well structure coupled by a weak probe field and a controlling field. It is shown that the threshold and hysteresis cycle of the optical bistability can be conveniently controlled only by adjusting the intensity of the SGC or the controlling field. Moreover, switching between optical bistability and multistability can be achieved. These studies may have practical significance for the preparation of optical bistable switching device.

  11. Tunable Bistability in Hybrid Bose-Einstein Condensate Optomechanics

    PubMed Central

    Yasir, Kashif Ammar; Liu, Wu-Ming

    2015-01-01

    Cavity-optomechanics, a rapidly developing area of research, has made a remarkable progress. A stunning manifestation of optomechanical phenomena is in exploiting the mechanical effects of light to couple the optical degree of freedom with mechanical degree of freedom. In this report, we investigate the controlled bistable dynamics of such hybrid optomechanical system composed of cigar-shaped Bose-Einstein condensate (BEC) trapped inside high-finesse optical cavity with one moving-end mirror and is driven by a single mode optical field. The numerical results provide evidence for controlled optical bistability in optomechanics using transverse optical field which directly interacts with atoms causing the coupling of transverse field with momentum side modes, exited by intra-cavity field. This technique of transverse field coupling is also used to control bistable dynamics of both moving-end mirror and BEC. The report provides an understanding of temporal dynamics of moving-end mirror and BEC with respect to transverse field. Moreover, dependence of effective potential of the system on transverse field has also been discussed. To observe this phenomena in laboratory, we have suggested a certain set of experimental parameters. These findings provide a platform to investigate the tunable behavior of novel phenomenon like electromagnetically induced transparency and entanglement in hybrid systems. PMID:26035206

  12. Bistable liquid crystal device fabricated via microscale liquid crystal alignment

    NASA Astrophysics Data System (ADS)

    Honma, Michinori; Toyoshima, Wataru; Nose, Toshiaki

    2016-10-01

    Bistable liquid crystal (LC) molecular orientation properties in micropatterned LC cells were investigated experimentally and theoretically. When an LC cell was heated to the phase-transition temperature and then cooled, an LC orientation with ±π/2-twist domains (±π/2-twist mode) was obtained. Furthermore, a different LC orientation with ±π-twist domains (±π-twist mode) was observed when a 10-V potential was applied across a sample LC cell. Both orientation states were stably retained over a long period. Herein, cross-sectional LC orientation models in the ±π/2- and ±π-twist modes are proposed to explain the generation and behavior of two different disclination lines. The total energies within one period in the ±π/2- and ±π-twist modes (F±π/2 and F±π, respectively) were estimated theoretically. These energies were found to depend on the LC layer thickness and to cross over at a certain thickness; this indicates that F±π is equal to F±π/2 at this equilibrium thickness. The best temporal stability is likely attained at this equilibrium thickness. We demonstrated a bistable color-switching device by combining a full-wave plate and crossed polarizers. When these optical components were configured properly, stable bistable switching between two colors was achieved.

  13. Rigid therapies, rigid minds: italian professionals' perspectives on autism interventions.

    PubMed

    Cascio, M Ariel

    2015-06-01

    Many therapies, interventions, and programs seek to improve outcomes and quality of life for people diagnosed with autism spectrum conditions. This paper addresses Italian professionals' perspectives on a variety of such interventions, including TEACCH, ABA, Defeat Autism Now!, and Doman-Delacato. Drawing on participant-observation and interviews collected in 2012-2013 in a northern region of Italy, it highlights the theme of "rigidity" that appears in professionals' discourses about both the characteristics of people with autism and the potential risks of adhering too strictly to any particular treatment protocol. The co-occurrence of the theme of rigidity across different domains demonstrates a way in which diagnostic characteristics become metaphors for medical practice. This paper proposes that such discursive moves may help bridge the gap between people with autism and people who work with them because a key attribute of people with autism-thinking and/or acting rigidly-is also a potential pitfall for people without autism.

  14. Chemistry of polyhalogenated nitrobutadienes, 10: Synthesis of highly functionalized heterocycles with a rigid 6-amino-3-azabicyclo[3.1.0]hexane moiety.

    PubMed

    Zapol'skii, Viktor A; Namyslo, Jan C; de Meijere, Armin; Kaufmann, Dieter E

    2012-01-01

    The nitropolychlorobutadienes 3, 4 are valuable building blocks for various amination and successive heterocyclization products. Nucleophilic substitution reactions of the partially protected, bioactive amines 1, 2 with either vinyl, imidoyl or carbonyl chlorides result in the formation of the enamines 11, 12, 13, 16, 25, the amidine 6, and the amides 20, 21, respectively. In the following, cyclization to the highly functionalized pyrazoles 27, 28, pyrimidine 26 and pyridopyrimidine 24 succeeded. Deprotection of 21, 12 and 28 proved to be only partially feasible.

  15. Chemistry of polyhalogenated nitrobutadienes, 10: Synthesis of highly functionalized heterocycles with a rigid 6-amino-3-azabicyclo[3.1.0]hexane moiety

    PubMed Central

    Zapol’skii, Viktor A; Namyslo, Jan C; de Meijere, Armin

    2012-01-01

    Summary The nitropolychlorobutadienes 3, 4 are valuable building blocks for various amination and successive heterocyclization products. Nucleophilic substitution reactions of the partially protected, bioactive amines 1, 2 with either vinyl, imidoyl or carbonyl chlorides result in the formation of the enamines 11, 12, 13, 16, 25, the amidine 6, and the amides 20, 21, respectively. In the following, cyclization to the highly functionalized pyrazoles 27, 28, pyrimidine 26 and pyridopyrimidine 24 succeeded. Deprotection of 21, 12 and 28 proved to be only partially feasible. PMID:22563360

  16. Rigidly foldable origami gadgets and tessellations

    PubMed Central

    Evans, Thomas A.; Lang, Robert J.; Magleby, Spencer P.; Howell, Larry L.

    2015-01-01

    Rigidly foldable origami allows for motion where all deflection occurs at the crease lines and facilitates the application of origami in materials other than paper. In this paper, we use a recently discovered method for determining rigid foldability to identify existing flat-foldable rigidly foldable tessellations, which are also categorized. We introduce rigidly foldable origami gadgets which may be used to modify existing tessellations or to create new tessellations. Several modified and new rigidly foldable tessellations are presented. PMID:26473037

  17. Rigidity generation by nonthermal fluctuations

    NASA Astrophysics Data System (ADS)

    Sheshka, R.; Recho, P.; Truskinovsky, L.

    2016-05-01

    Active stabilization in systems with zero or negative stiffness is an essential element of a wide variety of biological processes. We study a prototypical example of this phenomenon and show how active rigidity, interpreted as a formation of a pseudowell in the effective energy landscape, can be generated in an overdamped stochastic system. We link the transition from negative to positive rigidity with time correlations in the additive noise, and we show that subtle differences in the out-of-equilibrium driving may compromise the emergence of a pseudowell.

  18. Rigidity generation by nonthermal fluctuations.

    PubMed

    Sheshka, R; Recho, P; Truskinovsky, L

    2016-05-01

    Active stabilization in systems with zero or negative stiffness is an essential element of a wide variety of biological processes. We study a prototypical example of this phenomenon and show how active rigidity, interpreted as a formation of a pseudowell in the effective energy landscape, can be generated in an overdamped stochastic system. We link the transition from negative to positive rigidity with time correlations in the additive noise, and we show that subtle differences in the out-of-equilibrium driving may compromise the emergence of a pseudowell.

  19. Stirring effects and bistability in the iodate-arsenous acid reaction: Premixed vs segregated flows

    NASA Astrophysics Data System (ADS)

    Hannon, L.; Horsthemke, W.

    1987-01-01

    Using a coalescence-dispersion model of the continuous flow-stirred tank reactor (CSTR), we study the effect of premixed vs nonpremixed reactant flows on chemical bistability. The region of bistability is smaller for segregated feed streams than for a fully premixed feed stream. The transition from flow branch to thermodynamic branch is particularly sensitive to the feed stream configuration.

  20. Stochastic bifurcations in a bistable Duffing-Van der Pol oscillator with colored noise.

    PubMed

    Xu, Yong; Gu, Rencai; Zhang, Huiqing; Xu, Wei; Duan, Jinqiao

    2011-05-01

    This paper aims to investigate Gaussian colored-noise-induced stochastic bifurcations and the dynamical influence of correlation time and noise intensity in a bistable Duffing-Van der Pol oscillator. By using the stochastic averaging method, theoretically, one can obtain the stationary probability density function of amplitude for the Duffing-Van der Pol oscillator and can reveal interesting dynamics under the influence of Gaussian colored noise. Stochastic bifurcations are discussed through a qualitative change of the stationary probability distribution, which indicates that system parameters, noise intensity, and noise correlation time, respectively, can be treated as bifurcation parameters. They also imply that the effects of multiplicative noise are rather different from that of additive noise. The results of direct numerical simulation verify the effectiveness of the theoretical analysis. Moreover, the largest Lyapunov exponent calculations indicate that P and D bifurcations have no direct connection. PMID:21728638

  1. Bifurcations Induced in a Bistable Oscillator via Joint Noises and Time Delay

    NASA Astrophysics Data System (ADS)

    Fu, Jin; Sun, Zhongkui; Xiao, Yuzhu; Xu, Wei

    2016-06-01

    In this paper, noise-induced and delay-induced bifurcations in a bistable Duffing-van der Pol (DVP) oscillator under time delay and joint noises are discussed theoretically and numerically. Based on the qualitative changes of the plane phase, delay-induced bifurcations are investigated in the deterministic case. However, in the stochastic case, the response of the system is a stochastic non-Markovian process owing to the existence of noise and time delay. Then, methods have been employed to derive the stationary probability density function (PDF) of the amplitude of the response. Accordingly, stochastic P-bifurcations can be observed with the variations in the qualitative behavior of the stationary PDF for amplitude. Furthermore, results from both theoretical analyses and numerical simulations best demonstrate the appearance of noise-induced and delay-induced bifurcations, which are in good agreement.

  2. Stochastic bifurcations in a bistable Duffing-Van der Pol oscillator with colored noise.

    PubMed

    Xu, Yong; Gu, Rencai; Zhang, Huiqing; Xu, Wei; Duan, Jinqiao

    2011-05-01

    This paper aims to investigate Gaussian colored-noise-induced stochastic bifurcations and the dynamical influence of correlation time and noise intensity in a bistable Duffing-Van der Pol oscillator. By using the stochastic averaging method, theoretically, one can obtain the stationary probability density function of amplitude for the Duffing-Van der Pol oscillator and can reveal interesting dynamics under the influence of Gaussian colored noise. Stochastic bifurcations are discussed through a qualitative change of the stationary probability distribution, which indicates that system parameters, noise intensity, and noise correlation time, respectively, can be treated as bifurcation parameters. They also imply that the effects of multiplicative noise are rather different from that of additive noise. The results of direct numerical simulation verify the effectiveness of the theoretical analysis. Moreover, the largest Lyapunov exponent calculations indicate that P and D bifurcations have no direct connection.

  3. Negligible fronto-parietal BOLD activity accompanying unreportable switches in bistable perception

    PubMed Central

    Brascamp, Jan; Blake, Randolph; Knapen, Tomas

    2015-01-01

    The human brain's executive systems play a vital role in deciding and selecting among actions. Selection among alternatives also occurs in the perceptual domain, for instance when perception switches between interpretations during perceptual bistability. Whether executive systems also underlie this functionality remains debated, with known fronto-parietal concomitants of perceptual switches being variously interpreted as reflecting the switches' cause, or as reflecting their consequences. We developed a paradigm where the two eyes receive different inputs and perception demonstrably switches between these inputs, yet where switches themselves are so inconspicuous as to become unreportable, minimizing their executive consequences. Fronto-parietal fMRI BOLD responses that accompany perceptual switches were similarly minimized in this paradigm, indicating that these reflect the switches' consequences rather than their cause. We conclude that perceptual switches do not always rely on executive brain areas, and that processes responsible for selection among alternatives may operate outside of the brain's executive systems. PMID:26436901

  4. Chlorine functionalization of a model phenolic C8-guanine adduct increases conformational rigidity and blocks extension by a Y-family DNA polymerase.

    PubMed

    Witham, Aaron A; Verwey, Anne M R; Sproviero, Michael; Manderville, Richard A; Sharma, Purshotam; Wetmore, Stacey D

    2015-06-15

    Certain phenoxyl radicals can attach covalently to the C8-site of 2'-deoxyguanosine (dG) to afford oxygen-linked C8-dG adducts. Such O-linked adducts can be chemically synthesized through a nucleophilic displacement reaction between a phenolate and a suitably protected 8-Br-dG derivative. This permits the generation of model O-linked C8-dG adducts on scales suitable for insertion into oligonucleotide substrates using solid-phase DNA synthesis. Variation of the C8-aryl moiety provides an opportunity to derive structure-activity relationships on adduct conformation in duplex DNA and replication bypass by DNA polymerases. In the current study, the influence of chlorine C8-dG functionalization on in vitro DNA replication by Klenow fragment exo(-) (Kf(-)) and the Y-family polymerase (Sulfolobus solfataricus P2 DNA polymerase IV (Dpo4)) has been determined. Model O-linked C8-dG adducts derived from the pentachlorophenoxyl radical ([PCP]G) and 2,4,6-trichlorophenoxyl radical ([TCP]G) were inserted into the reiterated G3-position of the NarI sequence (12-mer, NarI(12); and 22-mer, NarI(22)), which is a known hotspot for frameshift mutations mediated by N-linked polycyclic C8-dG adducts in bacterial mutagenesis. Within the NarI(12) duplex, the unsubstituted C8-phenoxy-dG ([PhO]G) adduct adopts a minimally perturbed B-form helix. Chlorination of [PhO]G to afford [PCP]G does not significantly change the adduct conformation within the NarI(12) duplex, as predicted by molecular dynamics simulations. However, when using NarI(22) for DNA synthesis in vitro, the chlorinated [PCP]G and [TCP]G lesions significantly block DNA replication by Kf(-) and Dpo4, whereas [PhO]G is readily bypassed. These findings highlight the impact that chlorine substituents impart to bulky C8-dG lesions.

  5. Optimal matrix rigidity for stress fiber polarization in stem cells

    PubMed Central

    Rehfeldt, F.; Brown, A. E. X.; Discher, D. E.; Safran, S. A.

    2010-01-01

    The shape and differentiation of human mesenchymal stem cells is especially sensitive to the rigidity of their environment; the physical mechanisms involved are unknown. A theoretical model and experiments demonstrate here that the polarization/alignment of stress-fibers within stem cells is a non-monotonic function of matrix rigidity. We treat the cell as an active elastic inclusion in a surrounding matrix whose polarizability, unlike dead matter, depends on the feedback of cellular forces that develop in response to matrix stresses. The theory correctly predicts the monotonic increase of the cellular forces with the matrix rigidity and the alignment of stress-fibers parallel to the long axis of cells. We show that the anisotropy of this alignment depends non-monotonically on matrix rigidity and demonstrate it experimentally by quantifying the orientational distribution of stress-fibers in stem cells. These findings offer a first physical insight for the dependence of stem cell differentiation on tissue elasticity. PMID:20563235

  6. Rigidity-tuning conductive elastomer

    NASA Astrophysics Data System (ADS)

    Shan, Wanliang; Diller, Stuart; Tutcuoglu, Abbas; Majidi, Carmel

    2015-06-01

    We introduce a conductive propylene-based elastomer (cPBE) that rapidly and reversibly changes its mechanical rigidity when powered with electrical current. The elastomer is rigid in its natural state, with an elastic (Young’s) modulus of 175.5 MPa, and softens when electrically activated. By embedding the cPBE in an electrically insulating sheet of polydimethylsiloxane (PDMS), we create a cPBE-PDMS composite that can reversibly change its tensile modulus between 37 and 1.5 MPa. The rigidity change takes ˜6 s and is initiated when a 100 V voltage drop is applied across the two ends of the cPBE film. This magnitude of change in elastic rigidity is similar to that observed in natural skeletal muscle and catch connective tissue. We characterize the tunable load-bearing capability of the cPBE-PDMS composite with a motorized tensile test and deadweight experiment. Lastly, we demonstrate the ability to control the routing of internal forces by embedding several cPBE-PDMS ‘active tendons’ into a soft robotic pneumatic bending actuator. Selectively activating the artificial tendons controls the neutral axis and direction of bending during inflation.

  7. Quantum dissipative dynamics of a bistable system in the sub-Ohmic to super-Ohmic regime

    NASA Astrophysics Data System (ADS)

    Magazzù, Luca; Carollo, Angelo; Spagnolo, Bernardo; Valenti, Davide

    2016-05-01

    We investigate the quantum dynamics of a multilevel bistable system coupled to a bosonic heat bath beyond the perturbative regime. We consider different spectral densities of the bath, in the transition from sub-Ohmic to super-Ohmic dissipation, and different cutoff frequencies. The study is carried out by using the real-time path integral approach of the Feynman–Vernon influence functional. We find that, in the crossover dynamical regime characterized by damped intrawell oscillations and incoherent tunneling, the short time behavior and the time scales of the relaxation starting from a nonequilibrium initial condition depend nontrivially on the spectral properties of the heat bath.

  8. Quantum dissipative dynamics of a bistable system in the sub-Ohmic to super-Ohmic regime

    NASA Astrophysics Data System (ADS)

    Magazzù, Luca; Carollo, Angelo; Spagnolo, Bernardo; Valenti, Davide

    2016-05-01

    We investigate the quantum dynamics of a multilevel bistable system coupled to a bosonic heat bath beyond the perturbative regime. We consider different spectral densities of the bath, in the transition from sub-Ohmic to super-Ohmic dissipation, and different cutoff frequencies. The study is carried out by using the real-time path integral approach of the Feynman-Vernon influence functional. We find that, in the crossover dynamical regime characterized by damped intrawell oscillations and incoherent tunneling, the short time behavior and the time scales of the relaxation starting from a nonequilibrium initial condition depend nontrivially on the spectral properties of the heat bath.

  9. Bistability By Self-Reflection In A Saturable Absorber

    NASA Astrophysics Data System (ADS)

    Roso-Franco, Luis

    1987-01-01

    Propagation of laser light through a saturable absorber is theoretically studied. Computed steady state solutions of the Maxwell equations describing the unidimensional propagation of a plane monochromatic wave without introducing the slowly-varying envelope approximation are presented showing how saturation effects can influence the absorption of the field. At a certain range of refractive index and extintion coefficients, computed solutions display a very susprising behaviour, and a self-reflected wave appears inside the absorber. This can be useful for a new kind of biestable device, similar to a standard bistable cavity but with the back mirror self-induced by the light.

  10. Optical bistability of localized Josephson surface plasmons in cuprate superconductors.

    PubMed

    Alpeggiani, Filippo

    2015-03-15

    Microparticles made of high-Tc cuprate superconductors are characterized by localized plasmonic excitations known as Josephson surface plasmons, whose electromagnetic response is intrinsically nonlinear, giving rise to yet unexplored optical phenomena. In this work bistability effects in the near-resonance excitation of Josephson surface plasmons of dipolar symmetry are investigated for spheroidal superconducting particles. The threshold for the incident intensity is estimated, and experimental probing strategies are discussed. The system can be of interest in view of terahertz light switching and detection. PMID:25768133

  11. Bistable switching in dual-frequency liquid crystals

    SciTech Connect

    Palto, S. P. Barnik, M. I.

    2006-06-15

    Various bistable switching modes in nematic liquid crystals with frequency inversion of the sign of dielectric anisotropy are revealed and investigated. Switching between states with different helicoidal distributions of the director field of a liquid crystal, as well as between uniform and helicoidal states, is realized by dual-frequency waveforms of a driving voltage. A distinctive feature of the dual-frequency switching is that the uniform planar distribution of the director field may correspond to a thermodynamically equilibrium state, and the chirality of an LC is not a necessary condition for switching to a helicoidal state.

  12. Bistable switching in dual-frequency liquid crystals

    NASA Astrophysics Data System (ADS)

    Palto, S. P.; Barnik, M. I.

    2006-06-01

    Various bistable switching modes in nematic liquid crystals with frequency inversion of the sign of dielectric anisotropy are revealed and investigated. Switching between states with different helicoidal distributions of the director field of a liquid crystal, as well as between uniform and helicoidal states, is realized by dual-frequency waveforms of a driving voltage. A distinctive feature of the dual-frequency switching is that the uniform planar distribution of the director field may correspond to a thermodynamically equilibrium state, and the chirality of an LC is not a necessary condition for switching to a helicoidal state.

  13. Plastic latching accelerometer based on bistable compliant mechanisms

    NASA Astrophysics Data System (ADS)

    Hansen, B. J.; Carron, C. J.; Jensen, B. D.; Hawkins, A. R.; Schultz, S. M.

    2007-10-01

    This paper presents the design, fabrication, and testing of a miniature latching accelerometer that does not require electrical power. Latching is attained by using a bistable compliant mechanism that switches from one mechanical position to another when the force on the accelerometer exceeds a threshold value. Accelerometers were fabricated by laser cutting the compliant mechanism switch out of both ABS and Delrin plastic sheets. Packaging consisted of gluing the single compliant layer to a supporting substrate. The switching thresholds of the accelerometers were varied from 10g to 800g by varying the surface area of the free moving section between 100 and 500 mm2.

  14. Spatial Bistability Generates hunchback Expression Sharpness in the Drosophila Embryo

    PubMed Central

    Lopes, Francisco J. P.; Vieira, Fernando M. C.; Holloway, David M.; Bisch, Paulo M.; Spirov, Alexander V.

    2008-01-01

    During embryonic development, the positional information provided by concentration gradients of maternal factors directs pattern formation by providing spatially dependent cues for gene expression. In the fruit fly, Drosophila melanogaster, a classic example of this is the sharp on–off activation of the hunchback (hb) gene at midembryo, in response to local concentrations of the smooth anterior–posterior Bicoid (Bcd) gradient. The regulatory region for hb contains multiple binding sites for the Bcd protein as well as multiple binding sites for the Hb protein. Some previous studies have suggested that Bcd is sufficient for properly sharpened Hb expression, yet other evidence suggests a need for additional regulation. We experimentally quantified the dynamics of hb gene expression in flies that were wild-type, were mutant for hb self-regulation or Bcd binding, or contained an artificial promoter construct consisting of six Bcd and two Hb sites. In addition to these experiments, we developed a reaction–diffusion model of hb transcription, with Bcd cooperative binding and hb self-regulation, and used Zero Eigenvalue Analysis to look for multiple stationary states in the reaction network. Our model reproduces the hb developmental dynamics and correctly predicts the mutant patterns. Analysis of our model indicates that the Hb sharpness can be produced by spatial bistability, in which hb self-regulation produces two stable levels of expression. In the absence of self-regulation, the bistable behavior vanishes and Hb sharpness is disrupted. Bcd cooperative binding affects the position where bistability occurs but is not itself sufficient for a sharp Hb pattern. Our results show that the control of Hb sharpness and positioning, by hb self-regulation and Bcd cooperativity, respectively, are separate processes that can be altered independently. Our model, which matches the changes in Hb position and sharpness observed in different experiments, provides a theoretical

  15. Localization of Waves without Bistability: Worms in Nematic Electroconvection

    SciTech Connect

    Riecke, H.; Granzow, G.D.

    1998-07-01

    A general localization mechanism for waves in dissipative systems is identified that does not require the bistability of the basic state and the nonlinear plane-wave state. We conjecture that the mechanism explains the two-dimensional localized wave structures ({open_quotes}worms{close_quotes}) that recently have been observed in experiments on electroconvection in nematic liquid crystals where the transition to extended waves is supercritical. The mechanism accounts for the shape of the worms, their propagation direction, and certain aspects of their interaction. The dynamics of the localized waves can be steady or irregular. {copyright} {ital 1998} {ital The American Physical Society}

  16. Gradient sensing by a bistable regulatory motif enhances signal amplification but decreases accuracy in individual cells

    NASA Astrophysics Data System (ADS)

    Sharma, Rati; Roberts, Elijah

    2016-06-01

    Many vital eukaryotic cellular functions require the cell to respond to a directional gradient of a signaling molecule. The first two steps in any eukaryotic chemotactic/chemotropic pathway are gradient detection and cell polarization. Like many processes, such chemotactic and chemotropic decisions are made using a relatively small number of molecules and are thus susceptible to internal and external fluctuations during signal transduction. Large cell-to-cell variations in the magnitude and direction of a response are therefore possible and do, in fact, occur in natural systems. In this work we use three-dimensional probabilistic modeling of a simple gradient sensing pathway to study the capacity for individual cells to accurately determine the direction of a gradient, despite fluctuations. We include a stochastic external gradient in our simulations using a novel gradient boundary condition modeling a point emitter a short distance away. We compare and contrast three different variants of the pathway, one monostable and two bistable. The simulation data show that an architecture combining bistability with spatial positive feedback permits the cell to both accurately detect and internally amplify an external gradient. We observe strong polarization in all individual cells, but in a distribution of directions centered on the gradient. Polarization accuracy in our study was strongly dependent upon a spatial positive feedback term that allows the pathway to trade accuracy for polarization strength. Finally, we show that additional feedback links providing information about the gradient to multiple levels in the pathway can help the cell to refine initial inaccuracy in the polarization direction.

  17. The band structure of WO3 and non-rigid-band behaviour in Na0.67WO3 derived from soft x-ray spectroscopy and density functional theory.

    PubMed

    Chen, B; Laverock, J; Piper, L F J; Preston, A R H; Cho, S W; DeMasi, A; Smith, K E; Scanlon, D O; Watson, G W; Egdell, R G; Glans, P-A; Guo, J-H

    2013-04-24

    The electronic structure of single-crystal WO3 and Na0.67WO3 (a sodium-tungsten bronze) has been measured using soft x-ray absorption and resonant soft x-ray emission oxygen K-edge spectroscopies. The spectral features show clear differences in energy and intensity between WO3 and Na0.67WO3. The x-ray emission spectrum of metallic Na0.67WO3 terminates in a distinct Fermi edge. The rigid-band model fails to explain the electronic structure of Na0.67WO3 in terms of a simple addition of electrons to the conduction band of WO3. Instead, Na bonding and Na 3s-O 2p hybridization need to be considered for the sodium-tungsten bronze, along with occupation of the bottom of the conduction band. Furthermore, the anisotropy in the band structure of monoclinic γ-WO3 revealed by the experimental spectra with orbital-resolved geometry is explained via density functional theory calculations. For γ-WO3 itself, good agreement is found between the experimental O K-edge spectra and the theoretical partial density of states of O 2p orbitals. Indirect and direct bandgaps of insulating WO3 are determined from extrapolating separations between spectral leading edges and accounting for the core-hole energy shift in the absorption process. The O 2p non-bonding states show upward band dispersion as a function of incident photon energy for both compounds, which is explained using the calculated band structure and experimental geometry.

  18. Boolean models can explain bistability in the lac operon.

    PubMed

    Veliz-Cuba, Alan; Stigler, Brandilyn

    2011-06-01

    The lac operon in Escherichia coli has been studied extensively and is one of the earliest gene systems found to undergo both positive and negative control. The lac operon is known to exhibit bistability, in the sense that the operon is either induced or uninduced. Many dynamical models have been proposed to capture this phenomenon. While most are based on complex mathematical formulations, it has been suggested that for other gene systems network topology is sufficient to produce the desired dynamical behavior. We present a Boolean network as a discrete model for the lac operon. Our model includes the two main glucose control mechanisms of catabolite repression and inducer exclusion. We show that this Boolean model is capable of predicting the ON and OFF steady states and bistability. Further, we present a reduced model which shows that lac mRNA and lactose form the core of the lac operon, and that this reduced model exhibits the same dynamics. This work suggests that the key to model qualitative dynamics of gene systems is the topology of the network and Boolean models are well suited for this purpose. PMID:21563979

  19. Morphologies introduced by bistability in barred-spiral galactic potentials

    NASA Astrophysics Data System (ADS)

    Tsigaridi, L.; Patsis, P. A.

    2015-04-01

    We investigate the orbital dynamics of a barred-spiral model when the system is rotating slowly and corotation is located beyond the end of the spiral arms. In the characteristic of the central family of periodic orbits, we find a `bistable region'. In the response model, we observe a ring surrounding the bar and spiral arms starting tangential to the ring. This is a morphology resembling barred-spiral systems with inner rings. However, the dynamics associated with this structure in the case we study is different from that of a typical bar ending close to corotation. The ring of our model is round, or rather elongated perpendicular to the bar. It is associated with a folding (an `S'-shaped feature) of the characteristic of the central family, which is typical in bistable bifurcations. Along the `S' part of the characteristic, we have a change in the orientation of the periodic orbits from an x1-type to an x2-type morphology. The orbits populated in the response model change rather abruptly their orientation when reaching the lowest energy of the `S'. The spirals of the model follow a standard `precessing ellipses flow' and the orbits building them have energies beyond the `S' region. The bar is structured mainly by sticky orbits from regions around the stability islands of the central family. This leads to the appearance of X features in the bars on the galactic plane. Such a bar morphology appears in the unsharp-masked images of some moderately inclined galaxies.

  20. Dynamic analysis of bi-stable composite plates

    NASA Astrophysics Data System (ADS)

    Diaconu, Cezar G.; Weaver, Paul M.; Arrieta, Andres F.

    2009-05-01

    The static and dynamic transitions between stable states for rectangular bi-stable laminated composite plates are considered. The laminated composite plates have nonsymmetric laminate configurations and are subjected to thermal curing in order to introduce residual stresses and to achieve bi-stability. As geometrically nonlinear effects occur, after curing, the plates are able to take multiple stable shapes at service or room temperature. A simple model for dynamic analysis of the snap-through phenomena is proposed based on strain field approximations for the plates. Hamilton's principle is applied in conjunction with the Rayleigh-Ritz method in order to achieve fast results. The model is used to evaluate the initial displacements for the stable states and also to investigate the static and dynamic transitions from one stable state to another. Parametric studies are carried out for various aspect ratios, laminate configurations and actuation loads and the results are compared with those obtained with finite element analysis in order to evaluate the accuracy of the model.

  1. Experimental Study of Resistive Bistability in Metal Oxide Junctions

    SciTech Connect

    Su, D.; Tan, Z.; Patel, V.; Likharev, K.K.; Zhu, Y.

    2011-05-01

    We have studied resistive bistability (memory) effects in junctions based on metal oxides, with a focus on sample-to-sample reproducibility, which is necessary for the use of such junctions as crosspoint devices of hybrid CMOS/nanoelectronic circuits. Few-nm-thick layers of NbO{sub x}, CuO{sub x} and TiO{sub x} have been formed by thermal and plasma oxidation, at various deposition and oxidation conditions, both with and without rapid thermal post-annealing. The resistive bistability effect has been observed for all these materials, with particularly high endurance (over 10{sup 3} switching cycles) obtained for single-layer TiO{sub 2} junctions, and the best reproducibility reached for multi-layer junctions of the same material. Fabrication optimization has allowed us to improve the OFF/ON resistance ratio to about 10{sup 3}, but the sample-to-sample reproducibility is so far lower than that required for large-scale integration.

  2. A new concept for active bistable twisting structures

    NASA Astrophysics Data System (ADS)

    Schultz, Marc R.

    2005-05-01

    A novel type of morphing structure capable of a large change in shape with a small energy input is discussed in this paper. The considered structures consist of two curved shells that are joined in a specific manner to form a bistable airfoil-like structure. The two stable shapes have a difference in axial twist, and the structure may be transformed between the stable shapes by a simple snap-through action. The benefit of a bistable structure of this type is that, if the stable shapes are operational shapes, power is needed only to transform the structure from one shape to another. The discussed structures could be used in aerodynamic applications such as morphing wings, or as aerodynamic control surfaces. The investigation discussed in this paper considers both experiment and finite-element analysis. Several graphite-epoxy composite and one steel device were created as proof-of-concept models. To demonstrate active control of these structures, piezocomposite actuators were applied to one of the composite structures and used to transform the structure between stable shapes. The analysis was used to compare the predicted shapes with the experimental shapes, and to study how changes to the geometric input values affected the shape and operational characteristics of the structures. The predicted shapes showed excellent agreement with the experimental shapes, and the results of the parametric study suggest that the shapes and the snap-through characteristics can be easily tailored to meet specific needs.

  3. Optical bi-stable shutter development/improvement

    NASA Astrophysics Data System (ADS)

    Lizon, J. L.; Haddad, N.; Castillo, R.

    2012-09-01

    Two of the VLT instruments (Giraffe and VIMOS) are using the large magnetic E/150 from Prontor (with an aperture diameter of 150 mm). As we were facing an unacceptable number of failures with this component some improvement plan was discussed already in 2004. The final decision for starting this program was conditioned by the decision from the constructor to stop the production. The opportunity was taken to improve the design building a fully bi-stable mechanism in order to reduce the thermal dissipation. The project was developed in collaboration between the two main ESO sites doing the best use of the manpower and of the technical capability available at the two centers. The project took advantage of the laser Mask Manufacturing Unit and the invar sheets used to prepare the VIMOS MOS mask to fabricate the shutter petals. Our paper describes the development including the intensive and long optimization period. To conclude this optimization we proceed with a long life test on two units. These units have demonstrate a very high level of reliability (up to 100 000 cycles without failure which can be estimated to an equivalent 6 years of operation of the instrument) A new bi-stable shutter driver and controller have also been developed. Some of the highlights of this unit are the fully configurable coil driving parameters, usage of braking strategy to dump mechanical vibration and reduce mechanical wearing, configurable usage of OPEN and CLOSE sensors, non volatile storage of parameters, user friendly front panel interface.

  4. Compliant composite electrodes and large strain bistable actuation

    NASA Astrophysics Data System (ADS)

    Yun, Sungryul; Yu, Zhibin; Niu, Xiaofan; Hu, Weili; Li, Lu; Brochu, Paul; Pei, Qibing

    2012-04-01

    Dielectric elastomer actuators (DEA) and bistable electroactive polymers (BSEP) both require compliant electrodes with rubbery elasticity and high conductivity at large strains. Stretchable opto-electronic devices additionally require the compliant electrodes to be optically transparent. Many candidate materials have been investigated. We report a new approach to mechanically robust, stretchable compliant electrodes. A facile in-situ composite synthesis and transfer technique is employed, and the resulting composite electrodes retain the high surface conductivity of the original conductive network formed by nanowires or nanotubes, while exhibiting the mechanical flexibility of the matrix polymer. The composite electrodes have high transparency and low surface roughness useful for the fabrication of polymer thinfilm electronic devices. The new electrodes are suitable for high-strain actuation, as a complaint resistive heating element to administer the temperature of shape memory polymers, and as the charge injection electrodes for flexible/stretchable polymer light emitting diodes. Bistable electroactive polymers employing the composite electrodes can be actuated to large strains via heating-actuation-cooling cycles.

  5. Rigidity analysis of protein biological assemblies and periodic crystal structures

    PubMed Central

    2013-01-01

    Background We initiate in silico rigidity-theoretical studies of biological assemblies and small crystals for protein structures. The goal is to determine if, and how, the interactions among neighboring cells and subchains affect the flexibility of a molecule in its crystallized state. We use experimental X-ray crystallography data from the Protein Data Bank (PDB). The analysis relies on an effcient graph-based algorithm. Computational experiments were performed using new protein rigidity analysis tools available in the new release of our KINARI-Web server http://kinari.cs.umass.edu. Results We provide two types of results: on biological assemblies and on crystals. We found that when only isolated subchains are considered, structural and functional information may be missed. Indeed, the rigidity of biological assemblies is sometimes dependent on the count and placement of hydrogen bonds and other interactions among the individual subchains of the biological unit. Similarly, the rigidity of small crystals may be affected by the interactions between atoms belonging to different unit cells. We have analyzed a dataset of approximately 300 proteins, from which we generated 982 crystals (some of which are biological assemblies). We identified two types of behaviors. (a) Some crystals and/or biological assemblies will aggregate into rigid bodies that span multiple unit cells/asymmetric units. Some of them create substantially larger rigid cluster in the crystal/biological assembly form, while in other cases, the aggregation has a smaller effect just at the interface between the units. (b) In other cases, the rigidity properties of the asymmetric units are retained, because the rigid bodies did not combine. We also identified two interesting cases where rigidity analysis may be correlated with the functional behavior of the protein. This type of information, identified here for the first time, depends critically on the ability to create crystals and biological assemblies

  6. Rigidity spectrum of Forbush decrease

    NASA Technical Reports Server (NTRS)

    Sakakibara, S.; Munakata, K.; Nagashima, K.

    1985-01-01

    Using data from neutron monitors and muon telescopes at surface and underground stations, the average rigidity spectrum of Forbush decreases (Fds) during the period of 1978-1982 were obtained. Thirty eight Ed-events are classified into two groups Hard Fd and Soft Fd according to size of Fd at Sakashita station. It is found that a spectral form of fractional-power type (P to the-gamma sub 1 (P+P sub c) to the -gamma sub2) is more suitable for the present purpose than that of power-exponential type or of power type with an upper limiting rigidity. The best fitted spectrum of fractional-power type is expressed by gamma sub1 = 0.37, gamma sub2 = 0.89 and P subc = 10 GV for Hard Fd and gamma sub1 = 0.77, gamma sub2 = 1.02 and P sub c - 14GV for Soft Fd.

  7. Saddle-shaped, bistable morphing panel with shape memory alloy spring actuator

    NASA Astrophysics Data System (ADS)

    Lee, Jong-Gu; Ryu, Junghyun; Lee, Hyeok; Cho, Maenghyo

    2014-07-01

    Bistable structures are attractive morphing components because they can transform from one stable state to another simply through the application of an external force or moment. Each stable state is preserved despite the absence of a continuous energy supply. However, its competency is quite limited because most bistable composites (unsymmetric laminated bistable composites) have limited equilibrium shape configurations after curing. Most of them are cylindrical in shape. In this paper, for the first time, we present a saddle-shaped bistable panel that can be used for various soft-morphing applications. The mechanics of the saddle-shaped, bistable panel are investigated using the Rayleigh-Ritz approximation. A simple analytical model is proposed to obtain saddle bistability and deformations. Finite element (FE) numerical analysis is also performed to validate the analytical model approach. The numerical FE analysis shows good correlation with simple analytical solutions. Furthermore, for practical, smart-structure applications of the saddle-shaped bistable panel, the FE method simulated a snap-through action induced by a shape memory alloy (SMA) spring actuator. A simple design criterion for the snap-through action of a saddle composite panel actuated by an SMA spring component is suggested, based on the FE analysis.

  8. Quasiclassical trajectory studies of rigid rotor--rigid surface scattering. I. Flat surface

    SciTech Connect

    Bowman, J.M.; Park, S.C.

    1982-12-01

    Rotationally inelastic transition intensities are calculated for a model N/sub 2/ rigid rotor--rigid flat surface at initial collision energies of 104 and 3800 meV and for many initial beam orientations. The interaction potential is a Morse function modulated by a term which depends on the rotor orientation angle. The calculations are based on the quasiclassical trajectory method and a distorted trajectory perturbation theory. At the low collision energy the rotational excitation is mediated by the attractive part of the potential and by the repulsive part at high energies. The collision dynamics is direct in both energy regimes, however, quite complicated in the former one. Rotational rainbows are clearly observed for the high energy collisions.

  9. Decoding a bistable percept with integrated time-frequency representation of single-trial local field potential

    NASA Astrophysics Data System (ADS)

    Wang, Zhisong; Logothetis, Nikos K.; Liang, Hualou

    2008-12-01

    Bistable perception emerges when a stimulus under continuous view is perceived as the alternation of two mutually exclusive states. Such a stimulus provides a unique opportunity for understanding the neural basis of visual perception because it dissociates the perception from the visual input. In this paper we analyze the dynamic activity of local field potential (LFP), simultaneously collected from multiple channels in the middle temporal (MT) visual cortex of a macaque monkey, for decoding its bistable structure-from-motion (SFM) perception. Based on the observation that the discriminative information of neuronal population activity evolves and accumulates over time, we propose to select features from the integrated time-frequency representation of LFP using a relaxation (RELAX) algorithm and a sequential forward selection (SFS) algorithm with maximizing the Mahalanobis distance as the criterion function. The integrated-spectrogram based feature selection is much more robust and can achieve significantly better features than the instantaneous-spectrogram based feature selection. We exploit the support vector machines (SVM) classifier and the linear discriminant analysis (LDA) classifier based on the selected features to decode the reported perception on a single trial basis. Our results demonstrate the excellent performance of the integrated-spectrogram based feature selection and suggest that the features in the gamma frequency band (30-100 Hz) of LFP within specific temporal windows carry the most discriminative information for decoding bistable perception. The proposed integrated-spectrogram based feature selection approach may have potential for a myriad of applications involving multivariable time series such as brain-computer interfaces (BCI).

  10. Rotating rigid motion in general relativity

    SciTech Connect

    Mason, D.P.; Pooe, C.A.

    1987-11-01

    Kinematic and dynamic expressions are derived for the Lie derivative of vorticity along a particle world line in a rigid motion. It is found that the evolution of vorticity in a rigid motion is governed by the electric part of the Weyl tensor. Necessary and sufficient kinematic and dynamic conditions are established for a rotating rigid motion to be isometric.

  11. Responses of bistable piezoelectric-composite energy harvester by means of recurrences

    NASA Astrophysics Data System (ADS)

    Syta, Arkadiusz; Bowen, Christopher R.; Kim, H. Alicia; Rysak, Andrzej; Litak, Grzegorz

    2016-08-01

    In this paper we examine the modal response of a bistable electro-mechanical energy harvesting device based on characterization of the experimental time-series. A piezoelectric element attached to a vibrating bistable carbon-fibre reinforced polymer laminate plate was used for the conversion of mechanical vibrations to electrical energy under harmonic excitations at a variety of frequencies and amplitudes. The inherent bistability of the mechanical resonator and snap-through phenomenon between stable states were exploited for energy harvesting. To identify the dynamics of the response of the studied harvesting structure and the associated output power generation we used the Fourier spectrum and Recurrence Quantification Analysis (RQA).

  12. Comparison of Bistable Systems and Matched Filters in Non-Gaussian Noise

    NASA Astrophysics Data System (ADS)

    Zhang, Xinming; Yan, Jianfeng; Duan, Fabing

    2016-10-01

    In this paper, we report that for a weak signal buried in the heavy-tailed noise, the bistable system can outperform the matched filter, yielding a higher output signal-to-noise ratio (SNR) or a lower probability of error. Moreover, by adding mutually independent internal noise components to an array of bistable systems, the output SNR or the probability of error can be further improved via the mechanism of stochastic resonance (SR). These comparison results demonstrate the potential capability of bistable systems for detecting weak signals in non-Gaussian noise environments.

  13. The SNA analysis of a minimal model for bistability in the MAPK signaling cascade model

    NASA Astrophysics Data System (ADS)

    Hadač, O.; Schreiber, I.

    2013-12-01

    Successive phosphorylation cascades mediated by mitogen-activated protein kinases (MAPKs) are known to act as switches initiating various cellular processes. In addition, models of the MAPK reaction network are displaying other nonlinear phenomena including bistability and periodic oscillations. Recently bistability has been explained as a consequence of interaction between single and double phosphorylation/dephosphorylation pathways in the Stage 2 subsystem of the Huang-Ferrell model of the MAPK and a core bistable model has been proposed. Here we focus on a detailed stability analysis of the steady states of this minimal model. The analysis uses methods of convex analysis and stoichiometric network theory.

  14. Noise-Induced Bistable States and Their Mean Switching Time in Foraging Colonies

    NASA Astrophysics Data System (ADS)

    Biancalani, Tommaso; Dyson, Louise; McKane, Alan J.

    2014-01-01

    We investigate a type of bistability occurring in population systems where noise not only causes transitions between stable states, but also constructs the states themselves. We focus on the experimentally well-studied system of ants choosing between two food sources to illustrate the essential points, but the ideas are more general. The mean time for switching between the two bistable states of the system is calculated. This suggests a procedure for estimating, in a real system, the critical population size above which bistability ceases to occur.

  15. Method to estimate center of rigidity using vibration recordings

    USGS Publications Warehouse

    Safak, Erdal; Celebi, Mehmet

    1990-01-01

    A method to estimate the center of rigidity of buildings by using vibration recordings is presented. The method is based on the criterion that the coherence of translational motions with the rotational motion is minimum at the center of rigidity. Since the coherence is a function of frequency, a gross but frequency-independent measure of the coherency is defined as the integral of the coherence function over the frequency. The center of rigidity is determined by minimizing this integral. The formulation is given for two-dimensional motions. Two examples are presented for the method; a rectangular building with ambient-vibration recordings, and a triangular building with earthquake-vibration recordings. Although the examples given are for buildings, the method can be applied to any structure with two-dimensional motions.

  16. Barriers to Cooperation Aid Ideological Rigidity and Threaten Societal Collapse

    PubMed Central

    Jusup, Marko; Matsuo, Tadasu; Iwasa, Yoh

    2014-01-01

    Understanding the factors that promote, disrupt, or shape the nature of cooperation is one of the main tasks of evolutionary biology. Here, we focus on attitudes and beliefs supportive of in-group favoritism and strict adherence to moral consensus, collectively known as ideological rigidity, that have been linked with both ends of the political spectrum. The presence among the political right and the left is likely to make ideological rigidity a major determinant of the political discourse with an important social function. To better understand this function, we equip the indirect reciprocity framework – widely used to explain evaluation-mediated social cooperation – with multiple stylized value systems, each corresponding to the different degree of ideological rigidity. By running game theoretical simulations, we observe the competitive evolution of these systems, map conditions that lead to more ideologically rigid societies, and identify potentially disastrous outcomes. In particular, we uncover that barriers to cooperation aid ideological rigidity. The society may even polarize to the extent where social parasites overrun the population and cause the complete collapse of the social structure. These results have implications for lawmakers globally, warning against restrictive or protectionist policies. PMID:24809975

  17. Barriers to cooperation aid ideological rigidity and threaten societal collapse.

    PubMed

    Jusup, Marko; Matsuo, Tadasu; Iwasa, Yoh

    2014-05-01

    Understanding the factors that promote, disrupt, or shape the nature of cooperation is one of the main tasks of evolutionary biology. Here, we focus on attitudes and beliefs supportive of in-group favoritism and strict adherence to moral consensus, collectively known as ideological rigidity, that have been linked with both ends of the political spectrum. The presence among the political right and the left is likely to make ideological rigidity a major determinant of the political discourse with an important social function. To better understand this function, we equip the indirect reciprocity framework--widely used to explain evaluation-mediated social cooperation--with multiple stylized value systems, each corresponding to the different degree of ideological rigidity. By running game theoretical simulations, we observe the competitive evolution of these systems, map conditions that lead to more ideologically rigid societies, and identify potentially disastrous outcomes. In particular, we uncover that barriers to cooperation aid ideological rigidity. The society may even polarize to the extent where social parasites overrun the population and cause the complete collapse of the social structure. These results have implications for lawmakers globally, warning against restrictive or protectionist policies.

  18. Static friction between rigid fractal surfaces

    NASA Astrophysics Data System (ADS)

    Alonso-Marroquin, Fernando; Huang, Pengyu; Hanaor, Dorian A. H.; Flores-Johnson, E. A.; Proust, Gwénaëlle; Gan, Yixiang; Shen, Luming

    2015-09-01

    Using spheropolygon-based simulations and contact slope analysis, we investigate the effects of surface topography and atomic scale friction on the macroscopically observed friction between rigid blocks with fractal surface structures. From our mathematical derivation, the angle of macroscopic friction is the result of the sum of the angle of atomic friction and the slope angle between the contact surfaces. The latter is obtained from the determination of all possible contact slopes between the two surface profiles through an alternative signature function. Our theory is validated through numerical simulations of spheropolygons with fractal Koch surfaces and is applied to the description of frictional properties of Weierstrass-Mandelbrot surfaces. The agreement between simulations and theory suggests that for interpreting macroscopic frictional behavior, the descriptors of surface morphology should be defined from the signature function rather than from the slopes of the contacting surfaces.

  19. Lubrication of rigid ellipsida solids

    NASA Technical Reports Server (NTRS)

    Hamrock, B. J.; Dowson, D.

    1982-01-01

    The influence of geometry on the isothermal hydrodynamic film separating two rigid solids was investigated. The minimum film thickness is derived for fully flooded conjunctions by using the Reynolds boundary conditions. It was found that the minimum film thickness had the same speed, viscosity, and load dependence as Kapitza' classical solution. However, the incorporation of Reynolds boundary conditions resulted in an additional geometry effect. Solutions using the parabolic film approximation are compared by using the exact expression for the film in the analysis. Contour plots are known that indicate in detail the pressure developed between the solids.

  20. Rigid zeolite containing polyurethane foams

    DOEpatents

    Frost, Charles B.

    1985-01-01

    A closed cell rigid polyurethane foam has been prepared which contains up to about 60% by weight of molecular sieves capable of sorbing molecules with effective critical diameters of up to about 10 .ANG.. The molecular sieve component of the foam can be preloaded with catalysts or with reactive compounds that can be released upon activation of the foam to control and complete crosslinking after the foam is formed. The foam can also be loaded with water or other flame-retarding agents, after completion. Up to about 50% of the weight of the isocyanate component of the foam can be replaced by polyimide resin precursors for incorporation into the final polymeric network.

  1. Rigid zeolite containing polyurethane foams

    DOEpatents

    Frost, C.B.

    1984-05-18

    A closed cell rigid polyurethane foam has been prepared which contains up to about 60% by weight of molecular sieves capable of sorbing molecules with effective critical diameters of up to about 10 A. The molecular sieve component of the foam can be preloaded with catalysts or with reactive compounds that can be released upon activation of the foam to control and complete crosslinking after the foam is formed. The foam can also be loaded with water or other flame-retarding agents, after completion. Up to about 50% of the weight of the isocyanate component of the foam can be replaced by polyimide resin precursors for incorporation into the final polymeric network.

  2. Phenotypic bistability in Escherichia coli's central carbon metabolism

    PubMed Central

    Kotte, Oliver; Volkmer, Benjamin; Radzikowski, Jakub L; Heinemann, Matthias

    2014-01-01

    Fluctuations in intracellular molecule abundance can lead to distinct, coexisting phenotypes in isogenic populations. Although metabolism continuously adapts to unpredictable environmental changes, and although bistability was found in certain substrate-uptake pathways, central carbon metabolism is thought to operate deterministically. Here, we combine experiment and theory to demonstrate that a clonal Escherichia coli population splits into two stochastically generated phenotypic subpopulations after glucose-gluconeogenic substrate shifts. Most cells refrain from growth, entering a dormant persister state that manifests as a lag phase in the population growth curve. The subpopulation-generating mechanism resides at the metabolic core, overarches the metabolic and transcriptional networks, and only allows the growth of cells initially achieving sufficiently high gluconeogenic flux. Thus, central metabolism does not ensure the gluconeogenic growth of individual cells, but uses a population-level adaptation resulting in responsive diversification upon nutrient changes. PMID:24987115

  3. Bistability of patterns of synchrony in Kuramoto oscillators with inertia

    NASA Astrophysics Data System (ADS)

    Belykh, Igor V.; Brister, Barrett N.; Belykh, Vladimir N.

    2016-09-01

    We study the co-existence of stable patterns of synchrony in two coupled populations of identical Kuramoto oscillators with inertia. The two populations have different sizes and can split into two clusters where the oscillators synchronize within a cluster while there is a phase shift between the dynamics of the two clusters. Due to the presence of inertia, which increases the dimensionality of the oscillator dynamics, this phase shift can oscillate, inducing a breathing cluster pattern. We derive analytical conditions for the co-existence of stable two-cluster patterns with constant and oscillating phase shifts. We demonstrate that the dynamics, that governs the bistability of the phase shifts, is described by a driven pendulum equation. We also discuss the implications of our stability results to the stability of chimeras.

  4. Study of spatial signal transduction in bistable switches

    NASA Astrophysics Data System (ADS)

    Zhao, Qi; Yao, Cheng-Gui; Tang, Jun; Liu, Li-Wei

    2016-10-01

    Bistable switch modules are among the most important fundamental motifs in signal-transduction pathways. To better understand their spatial signal transduction, we model the diffusion process in the one-dimensional (1-D) domain. We find that when none of the elements diffuse, the response of the system exhibits a spatial switch-like property. However, when one of the elements is highly diffusible, the response of the system does not show any spatial switching behavior. Furthermore, we observe that the spatial responses of the system are more sensitive to the time constant of the switch when none of the elements are diffusible. Further, a slow loop keeps the system in the high steady state more positions than that in the fast loop. Finally, we consolidate our numerical results analytically by performing a mathematical method.

  5. Analytical model for optical bistability in nonlinear metal nano-antennae involving Kerr materials.

    PubMed

    Zhou, Fei; Liu, Ye; Li, Zhi-Yuan; Xia, Younan

    2010-06-21

    Optical bistability at nanoscale is a promising way to realize optical switching, a key component of integrated nanophotonic devices. In this work we present an analytical model for optical bistability in a metal nano-antenna involving Kerr nonlinear medium based on detailed analysis of the correlation between the incident and extinction light intensity under surface plasmon resonance (SPR). The model allows one to construct a clear picture on how the threshold, contrast, and other characteristics of optical bistability are influenced by the nonlinear coefficient, incident light intensity, local field enhancement factor, SPR peak width, and other physical parameters of the nano-antenna. It shows that the key towards low threshold power and high contrast optical bistability in the nanosystem is to reduce the SPR peak width. This can be achieved by reducing the absorption of metal materials or introducing gain media into nanosystems.

  6. REVIEWS OF TOPICAL PROBLEMS: Optical bistability, multistability, and instabilities in liquid crystals

    NASA Astrophysics Data System (ADS)

    Arakelyan, S. M.

    1987-12-01

    The physical aspects of the manifestation of optical bistability, instabilities, and stochasticity in strongly nonlinear media in the form of liquid crystals subjected to laser radiation fields are discussed. The stress is on experimental research. Optical bistability and multistability are considered for a number of light-induced effects in homogeneous and inhomogeneous liquid crystals. The special features of these effects in liquids crystals, associated with the field-induced structural phase transitions, are stressed and the concept of intrinsic (mirrorless) optical bistability is introduced. General nonlinear systems with optical bistability are considered. An analysis is made of instabilities and stochasticity manifested in experiments on light-induced reorientation of liquid crystals in the presence of fields of different origin, giving rise to oscillatory and chaotic processes in the case of self-modulation of the transmitted light.

  7. Comment on 'Observation of intrinsic bistability in resonant-tunneling structures'

    NASA Technical Reports Server (NTRS)

    Sollner, T. C. L. G.

    1987-01-01

    It is suggested that the intrinsic bistability observed by Goldman et al. (1987) occurred not because of charging of the well, as is claimed, but because of oscillations in the negative-resistance region. A typical I-V curve for a double-barrier resonant-tunneling (DBRT) diode which is known to be oscillating is presented. In a reply to this comment, Goldman et al. show that the series resistance (of about 100 ohms) in Sollner's sample leads to extrinsic, rather than intrinsic, bistability. It is furthermore suggested that the mere presence of an oscillation does not in itself exclude intrinsic bistability in a DBRT structure. It is also noted that the intrinsic bistability and buildup of negative charge-space in a DBRT structure well has been demonstrated experimentally by Payling et al. (1987).

  8. Bistable flows forced by precession in planetary cores

    NASA Astrophysics Data System (ADS)

    Cebron, D.

    2015-12-01

    The presence of the Moon leads the Earth to precess, which forces a flow in its outer core via the spheroidal Core-Mantle Boundary (CMB). Reciprocally, this is also true for the liquid core core of the Moon, but the CMB is rather a triaxial ellipsoid in this case. In this work, we investigate if the precession can force two different stable flows for the same control parameters, allowing then the core to switch from one state to the other in presence of noise (convection, turbulence, etc.). To do so, we systematically study the parameter ranges where the well-known equations obtained by Busse (1968 J. Fluid Mech. 33 739-51) lead to multiple solutions. Then, using the models recently proposed by Noir and Cébron (2013 J. Fluid Mech. 737 412-39), which are more generic in the inviscid limit than the equations of Busse, we analytically describe these multiple solutions, their conditions of existence, and their stability. We also report for the first time the theoretical possibility that time-dependent multiple flows can coexist in precessing triaxial ellipsoids (such as the liquid core of the Moon). Finally, using the formula we have derived from pre-existent models of the literature, we conclude that the Earth and the Moon do not undergo such a bistable flow forced by precession. However, according to the models of the literature, such a bistable precession forced state exists for geophysically relevant ranges of parameters, and is thus always possible a priori in precessing liquid cores of terrestrial bodies.

  9. Bistability in an uncatalyzed bromate oscillator in a continuously fed stirred tank reactor

    NASA Astrophysics Data System (ADS)

    Dutt, Arun K.; Müller, S. C.

    1996-01-01

    Uncatalyzed gallic acid oscillating system has been investigated in a continuously fed stirred tank reactor (CSTR). In the [Bromate]0-[Bromide]0 concentration space, a region has been located where a bistability is observed between an oscillatory branch and a flow branch. To our knowledge this is the first evidence of bistability in an uncatalyzed bromate oscillator. Some observations have been explained in terms of the skeleton mechanism proposed in the past.

  10. All-optical switching, bistability, and slow-light transmission in photonic crystal waveguide-resonator structures.

    PubMed

    Mingaleev, Sergei F; Miroshnichenko, Andrey E; Kivshar, Yuri S; Busch, Kurt

    2006-10-01

    We analyze the resonant linear and nonlinear transmission through a photonic crystal waveguide side-coupled to a Kerr-nonlinear photonic crystal resonator. First, we extend the standard coupled-mode theory analysis to photonic crystal structures and obtain explicit analytical expressions for the bistability thresholds and transmission coefficients which provide the basis for a detailed understanding of the possibilities associated with these structures. Next, we discuss limitations of standard coupled-mode theory and present an alternative analytical approach based on the effective discrete equations derived using a Green's function method. We find that the discrete nature of the photonic crystal waveguides allows a geometry-driven enhancement of nonlinear effects by shifting the resonator location relative to the waveguide, thus providing an additional control of resonant waveguide transmission and Fano resonances. We further demonstrate that this enhancement may result in the lowering of the bistability threshold and switching power of nonlinear devices by several orders of magnitude. Finally, we show that employing such enhancements is of paramount importance for the design of all-optical devices based on slow-light photonic crystal waveguides.

  11. Enhanced rigid-bond restraints

    SciTech Connect

    Thorn, Andrea; Dittrich, Birger; Sheldrick, George M.

    2012-07-01

    An extension is proposed to the rigid-bond description of atomic thermal motion in crystals. The rigid-bond model [Hirshfeld (1976 ▶). Acta Cryst. A32, 239–244] states that the mean-square displacements of two atoms are equal in the direction of the bond joining them. This criterion is widely used for verification (as intended by Hirshfeld) and also as a restraint in structure refinement as suggested by Rollett [Crystallographic Computing (1970 ▶), edited by F. R. Ahmed et al., pp. 167–181. Copenhagen: Munksgaard]. By reformulating this condition, so that the relative motion of the two atoms is required to be perpendicular to the bond, the number of restraints that can be applied per anisotropic atom is increased from about one to about three. Application of this condition to 1,3-distances in addition to the 1,2-distances means that on average just over six restraints can be applied to the six anisotropic displacement parameters of each atom. This concept is tested against very high resolution data of a small peptide and employed as a restraint for protein refinement at more modest resolution (e.g. 1.7 Å)

  12. Complications of rigid internal fixation.

    PubMed

    Campbell, Chris A; Lin, Kant Y

    2009-03-01

    Over the past 20 years, there have been many advances in the development of bone fixation systems used in the practice of craniomaxillofacial surgery. As surgical practices have evolved, the complications of each technologic advance have changed accordingly. Interfragmentary instability of interosseous wiring has been replaced by the risk of exposure, infection, and palpability of plate and screw fixation systems. The improved rigidity of plate fixation requires anatomic alignment of fracture fragments. Failure to obtain proper alignment has led to the phenomenon known as "open internal fixation" of fracture fragments without proper reduction. The size of the plates has decreased to minimize palpability and exposure. However limitations in their application have been encountered due to the physiologic forces of the muscles of mastication and bone healing. In the pediatric population, the long-standing presence of plates in the cranial vault resulted in reports of transcranial migration and growth restriction. These findings led to the development of resorbable plating systems, which are associated with self-limited plate palpability and soft tissue inflammatory reactions. Any rigid system including these produces growth restriction in varying amounts. In this discussion, we review the reported complication rates of miniplating and microplating systems as well as absorptive plating systems in elective and traumatic craniofacial surgery.

  13. Potential role of a bistable histidine kinase switch in the asymmetric division cycle of Caulobacter crescentus.

    PubMed

    Subramanian, Kartik; Paul, Mark R; Tyson, John J

    2013-01-01

    The free-living aquatic bacterium, Caulobacter crescentus, exhibits two different morphologies during its life cycle. The morphological change from swarmer cell to stalked cell is a result of changes of function of two bi-functional histidine kinases, PleC and CckA. Here, we describe a detailed molecular mechanism by which the function of PleC changes between phosphatase and kinase state. By mathematical modeling of our proposed molecular interactions, we derive conditions under which PleC, CckA and its response regulators exhibit bistable behavior, thus providing a scenario for robust switching between swarmer and stalked states. Our simulations are in reasonable agreement with in vitro and in vivo experimental observations of wild type and mutant phenotypes. According to our model, the kinase form of PleC is essential for the swarmer-to-stalked transition and to prevent premature development of the swarmer pole. Based on our results, we reconcile some published experimental observations and suggest novel mutants to test our predictions.

  14. Structural relaxation in complex liquids: non-Markovian dynamics in a bistable potential.

    PubMed

    Chaudhury, Srabanti; Cherayil, Binny J

    2006-11-14

    The time correlation function C(t) identical with of the distance fluctuations of a particle moving in a bistable potential under the action of fractional Gaussian noise (fGn) is calculated from a Smoluchowski-type equation derived from a generalized Langevin equation (GLE). The time derivative of this function, dC(t)dt, is compared with data from optical Kerr effect measurements of liquid crystal dynamics in the vicinity of the isotropic-to-nematic transition, which are related to the time derivative of an orientational correlation function. A number of characteristic features of the experimental decay curves, including short and intermediate time power law behavior and long time exponential relaxation, are qualitatively reproduced by the analytical calculations, even though the latter do not explicitly treat orientational degrees of freedom. The GLE formalism with fGn was, in fact, originally proposed as a model of protein conformational fluctuations, so the present results suggest that it may also serve more generally as a model of structural relaxation in complex condensed phase media.

  15. Low-threshold optical bistability of graphene-wrapped dielectric composite

    PubMed Central

    Huang, Yang; Miroshnichenko, Andrey E.; Gao, Lei

    2016-01-01

    We theoretically study the effective third-order nonlinear response and optical bistability of the 3D graphene based composite consisting of graphene wrapped dielectric nanoparticles embedded in dielectric host at terahertz frequencies. Taking into account the nonlinear conductivity of graphene, we derive the analytical expressions for the effective third-order nonlinear coefficient in weakly nonlinear limit. Moreover, for strong applied fields, the criterion for achieving optical bistability in such a graphene coated sphere, as well as the switching thresholds of optical bistability are discussed. We find that both and optical bistability are strongly dependent on the Fermi energy of graphene and it is possible to achieve very low switching thresholds under the normal graphene dissipation. We further propose a scheme to study the transmittance of this nonlinear composite slab. These results reveal novel regime of the optical bistability of the transmittance of light. We show that this kind of graphene-wrapped composite, which has tunable and low threshold optical bistability, can be the best candidate for unique nonlinear optical materials. PMID:26996451

  16. Low-threshold optical bistability of graphene-wrapped dielectric composite.

    PubMed

    Huang, Yang; Miroshnichenko, Andrey E; Gao, Lei

    2016-03-21

    We theoretically study the effective third-order nonlinear response and optical bistability of the 3D graphene based composite consisting of graphene wrapped dielectric nanoparticles embedded in dielectric host at terahertz frequencies. Taking into account the nonlinear conductivity of graphene, we derive the analytical expressions for the effective third-order nonlinear coefficient χe3 in weakly nonlinear limit. Moreover, for strong applied fields, the criterion for achieving optical bistability in such a graphene coated sphere, as well as the switching thresholds of optical bistability are discussed. We find that both χe3 and optical bistability are strongly dependent on the Fermi energy of graphene and it is possible to achieve very low switching thresholds under the normal graphene dissipation. We further propose a scheme to study the transmittance of this nonlinear composite slab. These results reveal novel regime of the optical bistability of the transmittance of light. We show that this kind of graphene-wrapped composite, which has tunable and low threshold optical bistability, can be the best candidate for unique nonlinear optical materials.

  17. Achieving high bit rate logical stochastic resonance in a bistable system by adjusting parameters

    NASA Astrophysics Data System (ADS)

    Yang, Ding-Xin; Gu, Feng-Shou; Feng, Guo-Jin; Yang, Yong-Min; Ball, Andrew

    2015-11-01

    The phenomenon of logical stochastic resonance (LSR) in a nonlinear bistable system is demonstrated by numerical simulations and experiments. However, the bit rates of the logical signals are relatively low and not suitable for practical applications. First, we examine the responses of the bistable system with fixed parameters to different bit rate logic input signals, showing that an arbitrary high bit rate LSR in a bistable system cannot be achieved. Then, a normalized transform of the LSR bistable system is introduced through a kind of variable substitution. Based on the transform, it is found that LSR for arbitrary high bit rate logic signals in a bistable system can be achieved by adjusting the parameters of the system, setting bias value and amplifying the amplitudes of logic input signals and noise properly. Finally, the desired OR and AND logic outputs to high bit rate logic inputs in a bistable system are obtained by numerical simulations. The study might provide higher feasibility of LSR in practical engineering applications. Project supported by the National Natural Science Foundation of China (Grant No. 51379526).

  18. Shape optimization of rigid inclusions for elastic plates with cracks

    NASA Astrophysics Data System (ADS)

    Shcherbakov, Viktor

    2016-06-01

    In the paper, we consider an optimal control problem of finding the most safe rigid inclusion shapes in elastic plates with cracks from the viewpoint of the Griffith rupture criterion. We make use of a general Kirchhoff-Love plate model with both vertical and horizontal displacements, and nonpenetration conditions are fulfilled on the crack faces. The dependence of the first derivative of the energy functional with respect to the crack length on regular shape perturbations of the rigid inclusion is analyzed. It is shown that there exists a solution of the optimal control problem.

  19. Nonrigid registration using regularization that accomodates local tissue rigidity

    NASA Astrophysics Data System (ADS)

    Ruan, Dan; Fessler, Jeffrey A.; Roberson, Michael; Balter, James; Kessler, Marc

    2006-03-01

    Regularized nonrigid medical image registration algorithms usually estimate the deformation by minimizing a cost function, consisting of a similarity measure and a penalty term that discourages "unreasonable" deformations. Conventional regularization methods enforce homogeneous smoothness properties of the deformation field; less work has been done to incorporate tissue-type-specific elasticity information. Yet ignoring the elasticity differences between tissue types can result in non-physical results, such as bone warping. Bone structures should move rigidly (locally), unlike the more elastic deformation of soft issues. Existing solutions for this problem either treat different regions of an image independently, which requires precise segmentation and incurs boundary issues; or use an empirical spatial varying "filter" to "correct" the deformation field, which requires the knowledge of a stiffness map and departs from the cost-function formulation. We propose a new approach to incorporate tissue rigidity information into the nonrigid registration problem, by developing a space variant regularization function that encourages the local Jacobian of the deformation to be a nearly orthogonal matrix in rigid image regions, while allowing more elastic deformations elsewhere. For the case of X-ray CT data, we use a simple monotonic increasing function of the CT numbers (in HU) as a "rigidity index" since bones typically have the highest CT numbers. Unlike segmentation-based methods, this approach is flexible enough to account for partial volume effects. Results using a B-spline deformation parameterization illustrate that the proposed approach improves registration accuracy in inhale-exhale CT scans with minimal computational penalty.

  20. Coherent distributions for the rigid rotator

    NASA Astrophysics Data System (ADS)

    Grigorescu, Marius

    2016-06-01

    Coherent solutions of the classical Liouville equation for the rigid rotator are presented as positive phase-space distributions localized on the Lagrangian submanifolds of Hamilton-Jacobi theory. These solutions become Wigner-type quasiprobability distributions by a formal discretization of the left-invariant vector fields from their Fourier transform in angular momentum. The results are consistent with the usual quantization of the anisotropic rotator, but the expected value of the Hamiltonian contains a finite "zero point" energy term. It is shown that during the time when a quasiprobability distribution evolves according to the Liouville equation, the related quantum wave function should satisfy the time-dependent Schrödinger equation.

  1. Optical bistability in a one-dimensional photonic crystal resonator using a reverse-biased pn-junction.

    PubMed

    Sodagar, Majid; Miri, Mehdi; Eftekhar, Ali A; Adibi, Ali

    2015-02-01

    Optical bistability provides a simple way to control light with light. We demonstrate low-power thermo-optical bistability caused by the Joule heating mechanism in a one-dimensional photonic crystal (PC) nanobeam resonator with a moderate quality factor (Q ~8900) with an embedded reverse-biased pn-junction. We show that the photocurrent induced by the linear absorption in this compact resonator considerably reduces the threshold optical power. The proposed approach substantially relaxes the requirements on the input optical power for achieving optical bistability and provides a reliable way to stabilize the bistable features of the device.

  2. Influence of Fano interference and incoherent processes on optical bistability in a four-level quantum dot nanostructure

    NASA Astrophysics Data System (ADS)

    Seyyed, Hossein Asadpour; G, Solookinejad; M, Panahi; E Ahmadi, Sangachin

    2016-03-01

    Role of Fano interference and incoherent pumping field on optical bistability in a four-level designed InGaN/GaN quantum dot nanostructure embedded in a unidirectional ring cavity are analyzed. It is found that intensity threshold of optical bistability can be manipulated by Fano interference. It is shown that incoherent pumping fields make the threshold of optical bistability behave differently by Fano interference. Moreover, in the presence of Fano interference the medium becomes phase-dependent. Therefore, the relative phase of applied fields can affect the behaviors of optical bistability and intensity threshold can be controlled easily.

  3. Anesthesia for adult rigid bronchoscopy.

    PubMed

    Dincq, A S; Gourdin, M; Collard, E; Ocak, S; D'Odémont, J P; Dahlqvist, C; Lacrosse, D; Putz, L

    2014-01-01

    Rigid bronchoscopy under general anesthesia enables performing diagnostic and/or therapeutic procedures in the tracheobronchial tree. This technique is characterized by specific technical problems, insofar as the anesthesiologist and the operators share the same space, namely the airway. Several potential complications (hemorrhage inside the airway, threat to ventilation ...) may arise. These challenges render the ability to use the variable available techniques essential, as well as knowledge of the complications they could entail, and the ability to rapidly solve them. General anesthesia is usually total intravenous anesthesia, using short acting agents. Ventilation can be spontaneous, but more often insured using high-frequency jet ventilation. The hospital infrastructure and staff must have the expertise to perform this particular procedure, in order to limit the complication rate. PMID:25508517

  4. Anesthesia for adult rigid bronchoscopy.

    PubMed

    Dincq, A S; Gourdin, M; Collard, E; Ocak, S; D'Odémont, J P; Dahlqvist, C; Lacrosse, D; Putz, L

    2014-01-01

    Rigid bronchoscopy under general anesthesia enables performing diagnostic and/or therapeutic procedures in the tracheobronchial tree. This technique is characterized by specific technical problems, insofar as the anesthesiologist and the operators share the same space, namely the airway. Several potential complications (hemorrhage inside the airway, threat to ventilation ...) may arise. These challenges render the ability to use the variable available techniques essential, as well as knowledge of the complications they could entail, and the ability to rapidly solve them. General anesthesia is usually total intravenous anesthesia, using short acting agents. Ventilation can be spontaneous, but more often insured using high-frequency jet ventilation. The hospital infrastructure and staff must have the expertise to perform this particular procedure, in order to limit the complication rate. PMID:25470890

  5. Focused rigidity casts: an overview.

    PubMed

    Dagg, A R; Chockalingam, N; Branthwaite, H

    2013-02-01

    Focused rigidity casts (FRCs) are a novel treatment made from polymer semi-flexible cast material, used in the management of plantar foot ulceration to offload the site of ulceration. Current anecdotal evidence suggests that use of FRCs helps achieve quicker healing time. While FRCs were first used in the treatment of fractures, previous reports suggest that the FRC may be effective in the treatment of plantar foot ulceration. Although there is a paucity of evidence to support the use of FRCs in the treatment of foot ulceration, current evidence demonstrates a decrease in both wound healing time and plantar pressure. The aim of the paper is to examine the importance of offloading plantar ulcerations and introduce FRCs.

  6. Extracting a kinetic relation from the dynamics of a bistable chain

    NASA Astrophysics Data System (ADS)

    Zhao, Qingze; Purohit, Prashant K.

    2014-06-01

    We integrate Newton's second law for a chain of masses and bistable springs with a spinodal region with the goal of extracting a kinetic relation for propagating phase boundaries. Our numerical experiments correspond to the impact on a bar made of phase changing material. By reading off the spring extensions ahead and behind the phase boundaries in our numerical experiments, we compute a driving force and plot it as a function of the phase boundary velocity to get a kinetic relation. We then show that this kinetic relation results in solutions to Riemann problems in continuum bars that agree with the corresponding numerical experiments on the discrete mass-spring chain. We also integrate Langevin's equations of motion for the same chain of masses and springs to account for the presence of a heat bath at a fixed temperature. We find that the xt-plane looks similar to the purely mechanical numerical experiments at low temperatures but at high temperatures there is an increased incidence of random nucleation events. Using results from both impact and Riemann problems, we show that the kinetic relation is a function of the bath temperature.

  7. Mooring and ground handling rigid airships

    NASA Technical Reports Server (NTRS)

    Walker, H., Jr.

    1975-01-01

    The problems of mooring and ground handling rigid airships are discussed. A brief history of Mooring and Ground Handling Rigid Airships from July 2, 1900 through September 1, 1939 is included. Also a brief history of ground handling developments with large U. S. Navy nonrigid airships between September 1, 1939 and August 31, 1962 is included wherein developed equipment and techniques appear applicable to future large rigid airships. Finally recommendations are made pertaining to equipment and procedures which appear desirable and feasible for future rigid airship programs.

  8. Rigid multipodal platforms for metal surfaces.

    PubMed

    Valášek, Michal; Lindner, Marcin; Mayor, Marcel

    2016-01-01

    In this review the recent progress in molecular platforms that form rigid and well-defined contact to a metal surface are discussed. Most of the presented examples have at least three anchoring units in order to control the spatial arrangement of the protruding molecular subunit. Another interesting feature is the lateral orientation of these foot structures which, depending on the particular application, is equally important as the spatial arrangement of the molecules. The numerous approaches towards assembling and organizing functional molecules into specific architectures on metal substrates are reviewed here. Particular attention is paid to variations of both, the core structures and the anchoring groups. Furthermore, the analytical methods enabling the investigation of individual molecules as well as monomolecular layers of ordered platform structures are summarized. The presented multipodal platforms bearing several anchoring groups form considerably more stable molecule-metal contacts than corresponding monopodal analogues and exhibit an enlarged separation of the functional molecules due to the increased footprint, as well as restrict tilting of the functional termini with respect to the metal surface. These platforms are thus ideally suited to tune important properties of the molecule-metal interface. On a single-molecule level, several of these platforms enable the control over the arrangement of the protruding rod-type molecular structures (e.g., molecular wires, switches, rotors, sensors) with respect to the surface of the substrate. PMID:27335731

  9. Rigid multipodal platforms for metal surfaces

    PubMed Central

    Valášek, Michal; Lindner, Marcin

    2016-01-01

    Summary In this review the recent progress in molecular platforms that form rigid and well-defined contact to a metal surface are discussed. Most of the presented examples have at least three anchoring units in order to control the spatial arrangement of the protruding molecular subunit. Another interesting feature is the lateral orientation of these foot structures which, depending on the particular application, is equally important as the spatial arrangement of the molecules. The numerous approaches towards assembling and organizing functional molecules into specific architectures on metal substrates are reviewed here. Particular attention is paid to variations of both, the core structures and the anchoring groups. Furthermore, the analytical methods enabling the investigation of individual molecules as well as monomolecular layers of ordered platform structures are summarized. The presented multipodal platforms bearing several anchoring groups form considerably more stable molecule–metal contacts than corresponding monopodal analogues and exhibit an enlarged separation of the functional molecules due to the increased footprint, as well as restrict tilting of the functional termini with respect to the metal surface. These platforms are thus ideally suited to tune important properties of the molecule–metal interface. On a single-molecule level, several of these platforms enable the control over the arrangement of the protruding rod-type molecular structures (e.g., molecular wires, switches, rotors, sensors) with respect to the surface of the substrate. PMID:27335731

  10. Weak rigidity in the PPN formalism

    SciTech Connect

    del Olmo, V.; Olivert, J.

    1987-04-01

    The influence of the concept of weakly rigid almost-thermodynamic material schemes on the classical deformations is analyzed. The methods of the PPN approximation are considered. In this formalism, the equations that characterize the weak rigidity are expressed. As a consequence of that, an increase of two orders of magnitude in the strain rate tensor is obtained.

  11. 21 CFR 868.5540 - Rigid laryngoscope.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Rigid laryngoscope. 868.5540 Section 868.5540 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES ANESTHESIOLOGY DEVICES Therapeutic Devices § 868.5540 Rigid laryngoscope. (a) Identification....

  12. 21 CFR 868.5540 - Rigid laryngoscope.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 8 2014-04-01 2014-04-01 false Rigid laryngoscope. 868.5540 Section 868.5540 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES ANESTHESIOLOGY DEVICES Therapeutic Devices § 868.5540 Rigid laryngoscope. (a) Identification....

  13. 21 CFR 868.5540 - Rigid laryngoscope.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 8 2011-04-01 2011-04-01 false Rigid laryngoscope. 868.5540 Section 868.5540 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES ANESTHESIOLOGY DEVICES Therapeutic Devices § 868.5540 Rigid laryngoscope. (a) Identification....

  14. 21 CFR 868.5540 - Rigid laryngoscope.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 8 2012-04-01 2012-04-01 false Rigid laryngoscope. 868.5540 Section 868.5540 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES ANESTHESIOLOGY DEVICES Therapeutic Devices § 868.5540 Rigid laryngoscope. (a) Identification....

  15. 21 CFR 868.5540 - Rigid laryngoscope.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 8 2013-04-01 2013-04-01 false Rigid laryngoscope. 868.5540 Section 868.5540 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES ANESTHESIOLOGY DEVICES Therapeutic Devices § 868.5540 Rigid laryngoscope. (a) Identification....

  16. The Rigid Orthogonal Procrustes Rotation Problem

    ERIC Educational Resources Information Center

    ten Berge, Jos M. F.

    2006-01-01

    The problem of rotating a matrix orthogonally to a best least squares fit with another matrix of the same order has a closed-form solution based on a singular value decomposition. The optimal rotation matrix is not necessarily rigid, but may also involve a reflection. In some applications, only rigid rotations are permitted. Gower (1976) has…

  17. Tuning size and thermal hysteresis in bistable spin crossover nanoparticles.

    PubMed

    Galán-Mascarós, José Ramón; Coronado, Eugenio; Forment-Aliaga, Alicia; Monrabal-Capilla, María; Pinilla-Cienfuegos, Elena; Ceolin, Marcelo

    2010-06-21

    Nanoparticles of iron(II) triazole salts have been prepared from water-organic microemulsions. The mean size of the nanoparticles can be tuned down to 6 nm in diameter, with a narrow size distribution. A sharp spin transition from the low spin (LS) to the high spin (HS) state is observed above room temperature, with a 30-40-K-wide thermal hysteresis. The same preparation can yield second generation nanoparticles containing molecular alloys by mixing triazole with triazole derivatives, or from metallic mixtures of iron(II) and zinc(II). In these nanoparticles of 10-15 nm, the spin transition "moves" towards lower temperatures, reaching a 316 K limit for the cooling down transition and maintaining a thermal hysteresis over 15-20-K-wide. The nanoparticles were characterized by dynamic light scattering, TEM, and AFM, after deposition on gold or silicon surfaces. The spin transition was characterized by magnetic susceptibility measurements and EXAFS (in solid samples after solvent removal) and also by the color change between the LS (violet) and HS (colorless) states in an organic solvent suspension. The discovery of bistable magnetic nanoparticles of 6 nm with a wide thermal hysteresis above room temperature showcases the actual possibilities of spin crossover materials for nanotechnological applications. PMID:20503990

  18. Trim28 Haploinsufficiency Triggers Bi-stable Epigenetic Obesity

    PubMed Central

    Dalgaard, Kevin; Landgraf, Kathrin; Heyne, Steffen; Lempradl, Adelheid; Longinotto, John; Gossens, Klaus; Ruf, Marius; Orthofer, Michael; Strogantsev, Ruslan; Selvaraj, Madhan; Lu, Tess Tsai-Hsiu; Casas, Eduard; Teperino, Raffaele; Surani, M. Azim; Zvetkova, Ilona; Rimmington, Debra; Tung, Y.C. Loraine; Lam, Brian; Larder, Rachel; Yeo, Giles S.H.; O’Rahilly, Stephen; Vavouri, Tanya; Whitelaw, Emma; Penninger, Josef M.; Jenuwein, Thomas; Cheung, Ching-Lung; Ferguson-Smith, Anne C.; Coll, Anthony P.; Körner, Antje; Pospisilik, J. Andrew

    2016-01-01

    Summary More than one-half billion people are obese, and despite progress in genetic research, much of the heritability of obesity remains enigmatic. Here, we identify a Trim28-dependent network capable of triggering obesity in a non-Mendelian, “on/off” manner. Trim28+/D9 mutant mice exhibit a bi-modal body-weight distribution, with isogenic animals randomly emerging as either normal or obese and few intermediates. We find that the obese-“on” state is characterized by reduced expression of an imprinted gene network including Nnat, Peg3, Cdkn1c, and Plagl1 and that independent targeting of these alleles recapitulates the stochastic bi-stable disease phenotype. Adipose tissue transcriptome analyses in children indicate that humans too cluster into distinct sub-populations, stratifying according to Trim28 expression, transcriptome organization, and obesity-associated imprinted gene dysregulation. These data provide evidence of discrete polyphenism in mouse and man and thus carry important implications for complex trait genetics, evolution, and medicine. Video Abstract PMID:26824653

  19. Molecular mechanisms creating bistable switches at cell cycle transitions

    PubMed Central

    Verdugo, Anael; Vinod, P. K.; Tyson, John J.; Novak, Bela

    2013-01-01

    Progression through the eukaryotic cell cycle is characterized by specific transitions, where cells move irreversibly from stage i−1 of the cycle into stage i. These irreversible cell cycle transitions are regulated by underlying bistable switches, which share some common features. An inhibitory protein stalls progression, and an activatory protein promotes progression. The inhibitor and activator are locked in a double-negative feedback loop, creating a one-way toggle switch that guarantees an irreversible commitment to move forward through the cell cycle, and it opposes regression from stage i to stage i−1. In many cases, the activator is an enzyme that modifies the inhibitor in multiple steps, whereas the hypo-modified inhibitor binds strongly to the activator and resists its enzymatic activity. These interactions are the basis of a reaction motif that provides a simple and generic account of many characteristic properties of cell cycle transitions. To demonstrate this assertion, we apply the motif in detail to the G1/S transition in budding yeast and to the mitotic checkpoint in mammalian cells. Variations of the motif might support irreversible cellular decision-making in other contexts. PMID:23486222

  20. Bistability of atmospheric oxygen and the Great Oxidation.

    PubMed

    Goldblatt, Colin; Lenton, Timothy M; Watson, Andrew J

    2006-10-12

    The history of the Earth has been characterized by a series of major transitions separated by long periods of relative stability. The largest chemical transition was the 'Great Oxidation', approximately 2.4 billion years ago, when atmospheric oxygen concentrations rose from less than 10(-5) of the present atmospheric level (PAL) to more than 0.01 PAL, and possibly to more than 0.1 PAL. This transition took place long after oxygenic photosynthesis is thought to have evolved, but the causes of this delay and of the Great Oxidation itself remain uncertain. Here we show that the origin of oxygenic photosynthesis gave rise to two simultaneously stable steady states for atmospheric oxygen. The existence of a low-oxygen (less than 10(-5) PAL) steady state explains how a reducing atmosphere persisted for at least 300 million years after the onset of oxygenic photosynthesis. The Great Oxidation can be understood as a switch to the high-oxygen (more than 5 x 10(-3) PAL) steady state. The bistability arises because ultraviolet shielding of the troposphere by ozone becomes effective once oxygen levels exceed 10(-5) PAL, causing a nonlinear increase in the lifetime of atmospheric oxygen. Our results indicate that the existence of oxygenic photosynthesis is not a sufficient condition for either an oxygen-rich atmosphere or the presence of an ozone layer, which has implications for detecting life on other planets using atmospheric analysis and for the evolution of multicellular life.

  1. Optical switching and bistability in four-level atomic systems

    NASA Astrophysics Data System (ADS)

    Kumar, Pardeep; Dasgupta, Shubhrangshu

    2016-08-01

    We explore the coherent control of nonlinear absorption of intense laser fields in four-level atomic systems. For instance, in a four-level ladder system, a coupling field creates electromagnetically induced transparency (EIT) with an Aulter-Townes doublet for the probe field while the control field is absent. A large absorption peak appears at resonance as the control field is switched on. We show how such a large absorption leads to optical switching. Further, this large absorption diminishes and a transparency window appears due to the saturation effects as the strength of the probe field is increased. We further demonstrate that the threshold of the optical bistability can be modified by suitable choices of the coupling and the control fields. In a four-level Y -type configuration, the effect of the control field on saturable absorption (SA) and reverse saturable absorption (RSA) is highlighted in the context of nonlinear absorption of the probe field. We achieve RSA and SA in a simple atomic system just by applying a control field.

  2. High Resolution Quantification of Cellular Forces for Rigidity Sensing

    NASA Astrophysics Data System (ADS)

    Liu, Shuaimin

    This thesis describes a comprehensive study of understanding the mechanism of rigidity sensing by quantitative analysis using submicron pillar array substrates. From mechanobiology perspective, we explore and study molecular pathways involved in rigidity and force sensing at cell-matrix adhesions with regard to cancer, regeneration, and development by quantification methods. In Chapter 2 and 3, we developed fabrication and imaging techniques to enhance the performance of a submicron pillar device in terms of spatial and temporal measurement ability, and we discovered a correlation of rigidity sensing forces and corresponding proteins involved in the early rigidity sensing events. In Chapter 2, we introduced optical effect arising from submicron structure imaging, and we described a technique to identify the correct focal plane of pillar tip by fabricating a substrate with designed-offset pillars. From calibration result, we identified the correct focal plane that was previously overlooked, and verified our findings by other imaging techniques. In Chapter 3, we described several techniques to selectively functionalize elastomeric pillars top and compared these techniques in terms of purposes and fabrication complexity. Techniques introduced in this chapter included direct labeling, such as stamping of fluorescent substances (organic dye, nano-diamond, q-dot) to pillars top, as well as indirect labeling that selectively modify the surface of molds with either metal or fluorescent substances. In Chapter 4, we examined the characteristics of local contractility forces and identified the components formed a sarcomere like contractile unit (CU) that cells use to sense rigidity. CUs were found to be assembled at cell edge, contain myosin II, alpha-actinin, tropomodulin and tropomyosin (Tm), and resemble sarcomeres in size (˜2 mum) and function. Then we performed quantitative analysis of CUs to evaluate rigidity sensing activity over ˜8 hours time course and found that

  3. Determining the bistability parameter ranges of artificially induced lac operon using the root locus method.

    PubMed

    Avcu, N; Alyürük, H; Demir, G K; Pekergin, F; Cavas, L; Güzeliş, C

    2015-06-01

    This paper employs the root locus method to conduct a detailed investigation of the parameter regions that ensure bistability in a well-studied gene regulatory network namely, lac operon of Escherichia coli (E. coli). In contrast to previous works, the parametric bistability conditions observed in this study constitute a complete set of necessary and sufficient conditions. These conditions were derived by applying the root locus method to the polynomial equilibrium equation of the lac operon model to determine the parameter values yielding the multiple real roots necessary for bistability. The lac operon model used was defined as an ordinary differential equation system in a state equation form with a rational right hand side, and it was compatible with the Hill and Michaelis-Menten approaches of enzyme kinetics used to describe biochemical reactions that govern lactose metabolism. The developed root locus method can be used to study the steady-state behavior of any type of convergent biological system model based on mass action kinetics. This method provides a solution to the problem of analyzing gene regulatory networks under parameter uncertainties because the root locus method considers the model parameters as variable, rather than fixed. The obtained bistability ranges for the lac operon model parameters have the potential to elucidate the appearance of bistability for E. coli cells in in vivo experiments, and they could also be used to design robust hysteretic switches in synthetic biology. PMID:25864166

  4. Starting and Stopping a Bistable Pacemaker: Stochastic Stimulation Identifies Critical Perturbations

    NASA Astrophysics Data System (ADS)

    Paydarfar, David; Forger, Daniel B.; Clay, John R.

    2005-08-01

    Bistable pacemakers exhibit highly nonlinear properties, such as abrupt transitions between repetitive firing and quiescence in response to small perturbing stimuli. We describe a search method for estimating optimum stimulus shapes and intensities for starting or stopping the repetitive firing of a bistable pacemaker. A large library of randomly generated stimuli is used to perturb the pacemaker, and a library of responses is recorded. From these two libraries, a rank order of desirability of the stimulus is generated to arrive at an estimate of the optimum stimulus shape. The search method was validated by calculus of variations applied to the Bonhoeffer-van der Pol (Fitzhugh-Nagumo) model of a bistable pacemaker. We found that the optimum stimulus for inducing a switch from one stable attractor to the other is a critically timed oscillatory stimulus. While the optimum stimulus shape for stopping the oscillator is similar to that for starting the oscillator, they differ in that stopping the oscillator requires that the stimulus is in antiphase to the natural rhythm, while the optimum stimulus for starting the oscillator is in phase with the natural rhythm. These theoretical predictions can be tested in real biological pacemakers, such as a recently described squid giant axon preparation that exhibits membrane bistability. Elucidation of optimum stimulus shapes may be useful for studying many periodic phenomena in biology and medicine. Our findings also suggest a novel approach to understanding how bistable membranes encode information over long time scales using fast noisy transients.

  5. Deformable registration of multi-modal data including rigid structures

    SciTech Connect

    Huesman, Ronald H.; Klein, Gregory J.; Kimdon, Joey A.; Kuo, Chaincy; Majumdar, Sharmila

    2003-05-02

    Multi-modality imaging studies are becoming more widely utilized in the analysis of medical data. Anatomical data from CT and MRI are useful for analyzing or further processing functional data from techniques such as PET and SPECT. When data are not acquired simultaneously, even when these data are acquired on a dual-imaging device using the same bed, motion can occur that requires registration between the reconstructed image volumes. As the human torso can allow non-rigid motion, this type of motion should be estimated and corrected. We report a deformation registration technique that utilizes rigid registration for bony structures, while allowing elastic transformation of soft tissue to more accurately register the entire image volume. The technique is applied to the registration of CT and MR images of the lumbar spine. First a global rigid registration is performed to approximately align features. Bony structures are then segmented from the CT data using semi-automated process, and bounding boxes for each vertebra are established. Each CT subvolume is then individually registered to the MRI data using a piece-wise rigid registration algorithm and a mutual information image similarity measure. The resulting set of rigid transformations allows for accurate registration of the parts of the CT and MRI data representing the vertebrae, but not the adjacent soft tissue. To align the soft tissue, a smoothly-varying deformation is computed using a thin platespline(TPS) algorithm. The TPS technique requires a sparse set of landmarks that are to be brought into correspondence. These landmarks are automatically obtained from the segmented data using simple edge-detection techniques and random sampling from the edge candidates. A smoothness parameter is also included in the TPS formulation for characterization of the stiffness of the soft tissue. Estimation of an appropriate stiffness factor is obtained iteratively by using the mutual information cost function on the result

  6. Ammonia quantitative analysis model based on miniaturized Al ionization gas sensor and non-linear bistable dynamic model

    PubMed Central

    Ma, Rongfei

    2015-01-01

    In this paper, ammonia quantitative analysis based on miniaturized Al ionization gas sensor and non-linear bistable dynamic model was proposed. Al plate anodic gas-ionization sensor was used to obtain the current-voltage (I-V) data. Measurement data was processed by non-linear bistable dynamics model. Results showed that the proposed method quantitatively determined ammonia concentrations. PMID:25975362

  7. Optical bistability based on nonlinear oblique reflection of light beams from a screen with an aperture on its axis

    SciTech Connect

    Nikitenko, K Yu; Trofimov, V A

    1999-02-28

    It is shown that, in principle, optical bistability can be based on a nonlinear interaction of noncollinearly propagating beams when one of them is reflected from a plane screen with an aperture on its axis. The requirements to be satisfied by the interacting beams are discussed and estimates are obtained of the shortest response time of such an optically bistable system. (nonlinear optical phenomena)

  8. Sextic potential for \\gamma -rigid prolate nuclei

    NASA Astrophysics Data System (ADS)

    Buganu, P.; Budaca, R.

    2015-10-01

    The equation of the Bohr-Mottelson Hamiltonian with a sextic oscillator potential is solved for γ -rigid prolate nuclei. The associated shape phase space is reduced to three variables which are exactly separated. The angular equation has the spherical harmonic functions as solutions, while the β equation is converted to the quasi-exactly solvable case of the sextic oscillator potential with a centrifugal barrier. The energies and the corresponding wave functions are given in closed form and depend, up to a scaling factor, on a single parameter. The {0}+ and {2}+ states are exactly determined, having an important role in the assignment of some ambiguous states for the experimental β bands. Due to the special properties of the sextic potential, the model can simulate, by varying the free parameter, a shape phase transition from a harmonic to an anharmonic prolate β -soft rotor crossing through a critical point. Numerical applications are performed for 39 nuclei: {}98-108Ru, {}{100,102}Mo, {}116-130Xe, {}{132,134}Ce, {}146-150Nd, {}{150,152}Sm, {}{152,154}Gd, {}{154,156}Dy, 172Os, {}180-196Pt, 190Hg and 222Ra. The best candidates for the critical point are found to be 104Ru and {}{120,126}Xe, followed closely by 128Xe, 172Os, 196Pt and 148Nd.

  9. Bistable behavior of the lac operon in E. coli when induced with a mixture of lactose and TMG.

    PubMed

    Díaz-Hernández, Orlando; Santillán, Moisés

    2010-01-01

    In this work we investigate multistability in the lac operon of Escherichia coli when it is induced by a mixture of lactose and the non-metabolizable thiomethyl galactoside (TMG). In accordance with previously published experimental results and computer simulations, our simulations predict that: (1) when the system is induced by TMG, the system shows a discernible bistable behavior while, (2) when the system is induced by lactose, bistability does not disappear but excessively high concentrations of lactose would be required to observe it. Finally, our simulation results predict that when a mixture of lactose and TMG is used, the bistability region in the extracellular glucose concentration vs. extracellular lactose concentration parameter space changes in such a way that the model predictions regarding bistability could be tested experimentally. These experiments could help to solve a recent controversy regarding the existence of bistability in the lac operon under natural conditions. PMID:21423364

  10. Molecular Titration Promotes Oscillations and Bistability in Minimal Network Models with Monomeric Regulators.

    PubMed

    Cuba Samaniego, Christian; Giordano, Giulia; Kim, Jongmin; Blanchini, Franco; Franco, Elisa

    2016-04-15

    Molecular titration is emerging as an important biochemical interaction mechanism within synthetic devices built with nucleic acids and the CRISPR/Cas system. We show that molecular titration in the context of feedback circuits is a suitable mechanism to enhance the emergence of oscillations and bistable behaviors. We consider biomolecular modules that can be inhibited or activated by input monomeric regulators; the regulators compete with constitutive titrating species to determine the activity of their target. By tuning the titration rate and the concentration of titrating species, it is possible to modulate the delay and convergence speed of the transient response, and the steepness and dead zone of the stationary response of the modules. These phenomena favor the occurrence of oscillations when modules are interconnected to create a negative feedback loop; bistability is favored in a positive feedback interconnection. Numerical simulations are supported by mathematical analysis showing that the capacity of the closed loop systems to exhibit oscillations or bistability is structural.

  11. Bistability of a coupled Aurora B kinase-phosphatase system in cell division.

    PubMed

    Zaytsev, Anatoly V; Segura-Peña, Dario; Godzi, Maxim; Calderon, Abram; Ballister, Edward R; Stamatov, Rumen; Mayo, Alyssa M; Peterson, Laura; Black, Ben E; Ataullakhanov, Fazly I; Lampson, Michael A; Grishchuk, Ekaterina L

    2016-01-01

    Aurora B kinase, a key regulator of cell division, localizes to specific cellular locations, but the regulatory mechanisms responsible for phosphorylation of substrates located remotely from kinase enrichment sites are unclear. Here, we provide evidence that this activity at a distance depends on both sites of high kinase concentration and the bistability of a coupled kinase-phosphatase system. We reconstitute this bistable behavior and hysteresis using purified components to reveal co-existence of distinct high and low Aurora B activity states, sustained by a two-component kinase autoactivation mechanism. Furthermore, we demonstrate these non-linear regimes in live cells using a FRET-based phosphorylation sensor, and provide a mechanistic theoretical model for spatial regulation of Aurora B phosphorylation. We propose that bistability of an Aurora B-phosphatase system underlies formation of spatial phosphorylation patterns, which are generated and spread from sites of kinase autoactivation, thereby regulating cell division. PMID:26765564

  12. A computational role for bistability and traveling waves in motor cortex

    PubMed Central

    Heitmann, Stewart; Gong, Pulin; Breakspear, Michael

    2012-01-01

    Adaptive changes in behavior require rapid changes in brain states yet the brain must also remain stable. We investigated two neural mechanisms for evoking rapid transitions between spatiotemporal synchronization patterns of beta oscillations (13–30 Hz) in motor cortex. Cortex was modeled as a sheet of neural oscillators that were spatially coupled using a center-surround connection topology. Manipulating the inhibitory surround was found to evoke reliable transitions between synchronous oscillation patterns and traveling waves. These transitions modulated the simulated local field potential in agreement with physiological observations in humans. Intermediate levels of surround inhibition were also found to produce bistable coupling topologies that supported both waves and synchrony. State-dependent perturbation between bistable states produced very rapid transitions but were less reliable. We surmise that motor cortex may thus employ state-dependent computation to achieve very rapid changes between bistable motor states when the demand for speed exceeds the demand for accuracy. PMID:22973223

  13. Large Out-of-Plane Displacement Bistable Electromagnetic Microswitch on a Single Wafer

    PubMed Central

    Miao, Xiaodan; Dai, Xuhan; Huang, Yi; Ding, Guifu; Zhao, Xiaolin

    2016-01-01

    This paper presents a bistable microswitch fully batch-fabricated on a single glass wafer, comprising of a microactuator, a signal transformer, a microspring and a permanent magnet. The bistable mechanism of the microswitch with large displacement of 160 μm depends on the balance of the magnetic force and elastic force. Both the magnetic force and elastic force were optimized by finite-element simulation to predict the reliable of the device. The prototype was fabricated and characterized. By utilizing thick laminated photoresist sacrificial layer, the large displacement was obtained to ensure the insulation of the microswitch. The testing results show that the microswitch realized the bistable mechanism at a 3–5 V input voltage and closed in 0.96 ms, which verified the simulation. PMID:27164107

  14. Extrinsic periodic information interpolates between monostable and bistable states in intracellular calcium dynamics

    NASA Astrophysics Data System (ADS)

    Lin, Ling; Duan, Wei-Long

    2015-06-01

    Extrinsic periodic information including physiological cyclical and circadian replacement would affect inevitably a real cell, in this paper we investigate the effect of extrinsic periodic information on intracellular calcium dynamics by means of second-order algorithm for stochastic simulation colored noises. By simulating time evolutions and stationary probability distribution of intracellular Ca2+ concentrations, the results show: (i) intracellular calcium oscillation between cytosol and calcium store shows synchronous and anti-synchronous oscillation as intensity and frequency of extrinsic periodic information vary; (ii) extrinsic periodic information interpolates stability from bistable state → monostable state → bistable state → monostable state as frequency of extrinsic periodic information increases; (iii) extrinsic periodic information interpolates stability from monostable state → bistable state as intensity of extrinsic periodic information increases.

  15. Stochastic bifurcation, slow fluctuations, and bistability as an origin of biochemical complexity.

    PubMed

    Qian, Hong; Shi, Pei-Zhe; Xing, Jianhua

    2009-06-28

    We present a simple, unifying theory for stochastic biochemical systems with multiple time-scale dynamics that exhibit noise-induced bistability in an open-chemical environment, while the corresponding macroscopic reaction is unistable. Nonlinear stochastic biochemical systems like these are fundamentally different from classical systems in equilibrium or near-equilibrium steady state whose fluctuations are unimodal following Einstein-Onsager-Lax-Keizer theory. We show that noise-induced bistability in general arises from slow fluctuations, and a pitchfork bifurcation occurs as the rate of fluctuations decreases. Since an equilibrium distribution, due to detailed balance, has to be independent of changes in time-scale, the bifurcation is necessarily a driven phenomenon. As examples, we analyze three biochemical networks of currently interest: self-regulating gene, stochastic binary decision, and phosphorylation-dephosphorylation cycle with fluctuating kinase. The implications of bistability to biochemical complexity are discussed.

  16. Manipulating the optical bistability at terahertz frequency in the Fabry-Perot cavity with graphene.

    PubMed

    Jiang, Leyong; Guo, Jun; Wu, Leiming; Dai, Xiaoyu; Xiang, Yuanjiang

    2015-11-30

    We investigate theoretically the optical bistability from a Fabry-Perot cavity with graphene in the terahertz (THz) frequency. It is demonstrated that the optical bistablility in this cavity can be realized due to the electric field enhancement and the giant third-order nonlinear conductivity of graphene. The optical bistable behavior is strongly dependent on the transmission amplitude of the mirror and the position of the graphene in the cavity. It is especially important that the hysterical behaviors of the transmitted light rely on the optical conductivity of graphene, making the Fabry-Perot cavity to be a good candidate for dynamic tunable optical bistable device in the THz frequencies, owing to the possibility of high tunability of graphene conductivity by means of external electrostatic or magnetostatic field.

  17. Focused Role of an Organic Small-Molecule PBD on Performance of the Bistable Resistive Switching

    NASA Astrophysics Data System (ADS)

    Li, Lei; Sun, Yanmei; Ai, Chunpeng; Lu, Junguo; Wen, Dianzhong; Bai, Xuduo

    2015-11-01

    An undoped organic small-molecule 2-(4-tert-butylphenyl)-5-(4-biphenylyl)-1,3,4-oxadiazole (PBD) and a kind of nanocomposite blending poly(methyl methacrylate) (PMMA) into PBD are employed to implement bistable resistive switching. For the bistable resistive switching indium tin oxide (ITO)/PBD/Al, its ON/OFF current ratio can touch 6. What is more, the ON/OFF current ratio, approaching to 104, is available due to the storage layer PBD:PMMA with the chemical composition 1:1 in the bistable resistive switching ITO/PBD:PMMA/Al. The capacity, data retention of more than 1 year and endurance performance (>104 cycles) of ITO/PBD:PMMA(1:1)/Al, exhibits better stability and reliability of the samples, which underpins the technique and application of organic nonvolatile memory.

  18. Large Out-of-Plane Displacement Bistable Electromagnetic Microswitch on a Single Wafer.

    PubMed

    Miao, Xiaodan; Dai, Xuhan; Huang, Yi; Ding, Guifu; Zhao, Xiaolin

    2016-01-01

    This paper presents a bistable microswitch fully batch-fabricated on a single glass wafer, comprising of a microactuator, a signal transformer, a microspring and a permanent magnet. The bistable mechanism of the microswitch with large displacement of 160 μm depends on the balance of the magnetic force and elastic force. Both the magnetic force and elastic force were optimized by finite-element simulation to predict the reliable of the device. The prototype was fabricated and characterized. By utilizing thick laminated photoresist sacrificial layer, the large displacement was obtained to ensure the insulation of the microswitch. The testing results show that the microswitch realized the bistable mechanism at a 3-5 V input voltage and closed in 0.96 ms, which verified the simulation. PMID:27164107

  19. Sonar fetal cephalometry: comparison of bistable with gray scale and real-time techniques.

    PubMed

    Santos-Ramos, R; Duenhoelter, J H; Reisch, J S

    1980-03-15

    The fetal biparietal diameter was measured simultaneously with B-scan bistable and gray scale techniques and subsequently with real-time ultrasonography. Measurements were made from outer table to outer table with the bistable technique, which has been proven to be accurate and reliable. With the gray scale and real-time modalities, distances were measured between several landmarks from the same image. Off all measurements taken from gray scale and realtime images, those between the centers of each band outlining the fetal skull showed the best correlation and the closest values to measurements using the standard bistable technique. Discrepancies exceeded 2 mm in only 5% with the gray scale and in 2% with the real-time technique. Using the measurement between outer and inner aspects of the cephalic band, the percentages of discrepancies exceeding 2 mm were 7% with gray scale and 6% with real time.

  20. Low-threshold optical bistability with multilayer graphene-covering Otto configuration

    NASA Astrophysics Data System (ADS)

    Wang, Hengliang; Wu, Jipeng; Guo, Jun; Jiang, Leyong; Xiang, Yuanjiang; Wen, Shuangchun

    2016-06-01

    In this paper, we propose a modified Otto configuration to realize tunable and low-threshold optical bistability at terahertz frequencies by attaching multilayer graphene sheets to a nonlinear substrate interface. Our work demonstrates that the threshold of optical bistability can be markedly reduced (three orders of magnitude) by covering the nonlinear substrate with multilayer graphene sheets, due to strong local field enhancement with the excitation of surface plasmons. We present the influences of the Fermi energy of graphene, the incident angle, the thickness of air gap and the relaxation time of graphene on the hysteresis phenomenon and give a way to optimize the surface plasmon resonance, which will enable us to further lower the minimal power requirements for realizing optical bistability due to the strong interaction of light with graphene sheets. These results are promising for realization of terahertz optical switches, optical modulators and logical devices.

  1. Theoretical and experimental study of stochastic effects on polarization rotation in a vectorial bistable laser

    SciTech Connect

    Singh, Kamal P.; Ropars, Guy; Brunel, Marc; Le Floch, Albert

    2006-03-15

    We investigate the two-dimensional optical rotor of a weakly modulated vectorial bistable laser submitted to a single or multiple stochastic perturbations. In the Langevin-type equation of the rotor the role of an even or odd input forcing function on the system dynamics is isolated. Through these two inputs of optical and magnetic natures we verify that the stochastic resonance exists only when the periodic modulation acts on the even parity optical input. When two mutually correlated noises are simultaneously submitted to the input functions of opposite parities, we find a critical regime of the noise interplay whereby one stable state becomes noise-free. In this case, the residence time of the light vector in the noise-free state diverges which leads to a collapse of the output signal-to-noise ratio. But, in this critical regime also obtained when one noise drives both the even and odd functions, if the system symmetry is broken through an independent lever control, we can recover the switching cycle due to a new response mechanism, namely, the dual stochastic response, with a specific output signal-to-noise ratio expression. Both the theoretical analysis and the experiment show that the signal-to-noise ratio now displays a robust behavior for a large range of the input noise amplitude, and a plateau with respect to the input signal amplitude. Furthermore, we isolate an original signature of this synchronization mechanism in the residence-time distribution leading to a broadband forcing frequency range. These noise interplay effects in a double well potential are of generic nature and could be found in other nonlinear systems.

  2. Packing entropy of extended, hard, rigid objects on a lattice

    NASA Astrophysics Data System (ADS)

    Li, Wenshuo; Freed, Karl F.; Nemirovsky, Adolfo M.

    1993-06-01

    We present a systematic method of evaluating the packing entropy for a set of mutually avoiding extended, hard, rigid objects on a lattice. The method generalizes a simple algebraic representation of the lattice cluster theory developed by Freed and co-workers for systems composed of flexible objects. The theory provides a power series expansion in z-1 for the corrections to the zeroth order mean field approximation partition function, where z is the lattice coordination number. We illustrate the general theory by calculating the packing entropy of four-unit rigid ``square'' objects on a hypercubic lattice as a function of the volume fraction of the squares. As a particular limiting case, we also evaluate for the packing entropy of two, three, and four squares on a two-dimensional square lattice and find agreement with the cluster expansion.

  3. Cutoff solitons and bistability of the discrete inductance-capacitance electrical line: theory and experiments.

    PubMed

    Ve Koon, K Tse; Leon, J; Marquié, P; Tchofo-Dinda, P

    2007-06-01

    A discrete nonlinear system driven at one end by a periodic excitation of frequency above the upper band edge (the discreteness induced cutoff) is shown to be a means to (1) generate propagating breather excitations in a long chain and (2) reveal the bistable property of a short chain. After detailed numerical verifications, the bistability prediction is demonstrated experimentally on an electrical transmission line made of 18 inductance-capacitance (LC) cells. The numerical simulations of the LC -line model allow us also to verify the breather generation prediction with a striking accuracy.

  4. A silicon-nanowire memory driven by optical gradient force induced bistability

    SciTech Connect

    Dong, B.; Cai, H. Gu, Y. D.; Kwong, D. L.; Chin, L. K.; Ng, G. I.; Ser, W.; Huang, J. G.; Yang, Z. C.; Liu, A. Q.

    2015-12-28

    In this paper, a bistable optical-driven silicon-nanowire memory is demonstrated, which employs ring resonator to generate optical gradient force over a doubly clamped silicon-nanowire. Two stable deformation positions of a doubly clamped silicon-nanowire represent two memory states (“0” and “1”) and can be set/reset by modulating the light intensity (<3 mW) based on the optical force induced bistability. The time response of the optical-driven memory is less than 250 ns. It has applications in the fields of all optical communication, quantum computing, and optomechanical circuits.

  5. Optimal signal-to-noise ratio in stochastic time-delayed bistable systems

    NASA Astrophysics Data System (ADS)

    Gao, Shilong

    2016-04-01

    We study the optimal signal-to-noise ratio in a stochastic time-delayed bistable system. By using the small delay approximation, we transform the time-delayed system into stochastic nondelayed differential equations to obtain the analytic expressions of the signal-to-noise ratio in different mechanisms. In the valid range of small delay approximation, we compare the peak values of signal-to-noise ratio curves and obtain the optimal signal-to-noise ratio. From the results, we find that the interplay of time delay and noise has a great influence on time-delayed bistable systems.

  6. Observation of bistable resistance memory switching in CuO thin films

    NASA Astrophysics Data System (ADS)

    Kim, C. H.; Jang, Y. H.; Hwang, H. J.; Sun, Z. H.; Moon, H. B.; Cho, J. H.

    2009-03-01

    We report a bistable resistance switching behavior of CuO thin films. To understand the resistance switching mechanism, we have studied impedance spectroscopy and nanoscale electrical property. From the frequency-dependent impedance properties of CuO thin films in high resistance (ROFF) and low resistance (RON) states, we infer the formation of conducting paths generated by external bias as a possible origin of the bistable resistance states. In addition, the observation of inhomogeneous conducting path using a conducting atomic force microscope is also consistent with our inference.

  7. Theoretical study on a tunable directional coupler filter based optical bistable device and its possible applications

    NASA Astrophysics Data System (ADS)

    Podoleanu, Adrian G.; Sala, Anca-Liliana; Ionescu, Liviu G.

    1994-04-01

    We theoretically analyze the behavior of a hybrid optical bistable device that uses a tunable directional coupler filter as a modulator. The device is shown to have a great potential for applications in optical computing and optical communications. The output intensity dependencies on different input parameters are plotted and their basic features are exploited in imaging applications such as optical logical gates and other optical circuits. The spectral dependence of the pulse response of the bistable device is emphasized, suggesting the design of a very sensitive wavelength sensor.

  8. Bistability of self-modulation oscillations in an autonomous solid-state ring laser

    SciTech Connect

    Dudetskii, V Yu

    2013-11-30

    Bistable self-modulation regimes of generation for a ring YAG : Nd chip laser with the counterpropagating waves asymmetrically coupled via backward scattering are simulated numerically. Two branches of bistable self-modulation regimes of generation are found in the domain of the parametric resonance between the selfmodulation and relaxation oscillations. The self-modulation regimes observed in earlier experiments pertain to only one of the branches. Possible reasons for such a discrepancy are considered, related to the influence of technical and natural noise on the dynamics of solid-state ring lasers. (control of laser radiation parameters)

  9. Toward Singlet-Triplet Bistable Nonalternant Kekulé Hydrocarbons: Azulene-to-Naphthalene Rearrangement.

    PubMed

    Das, Soumyajit; Wu, Jishan

    2015-12-01

    Recent developments of open-shell singlet diradicaloids motivated the search for stable singlet-triplet bistable nonalternant polycyclic hydrocarbons. During the synthesis of this type of molecule, such as the dibenzo-cyclohepta[def]fluorene 3, an unexpected azulene-to-naphthalene rearrangement was observed at room temperature, which resulted in new nonalternant hydrocarbons 8a/8b with a closed-shell singlet ground state. These studies provided insight into the unique chemistry of azulene and challenges for the synthesis of singlet-triplet bistable polycyclic hydrocarbons. PMID:26569547

  10. Hybrid Optoelectronic Bistability in Frequency-Domain and Its Potential Application in FBG Sensors

    NASA Astrophysics Data System (ADS)

    Ye, Hong-An; Liu, Chun-Yu; Lv, Guo-Hui; Xin, Hai-Ying; Zhu, Xiao-Liang

    2008-12-01

    We propose a novel optical bistable device (OBD) in frequency-domain with which we can perform optical bistable operations in a number of fibre Bragg gratings (FBGs) which are included in the same OBD. Such an OBD may bring more opportunities in applications and, as an example, we show the possibility of using it in an FBG sensor demodulating system. By use of a tunable light source, consisting of a broad band source and a scanning fibre F-P (FFP), we demonstrate the above-mentioned operations experimentally.

  11. Random telegraphic voltage noise due to thermal bi-stability in a superconducting weak link

    NASA Astrophysics Data System (ADS)

    Biswas, Sourav; Kumar, Nikhil; Winkelmann, C. B.; Courtois, Herve; Gupta, Anjan K.

    2016-05-01

    We investigated the random telegraphic voltage noise signal in the hysteretic bi-stable state of a superconducting weak link device. Fluctuation induced random switching between zero voltage state and non-zero-voltage state gives rise to a random telegraphic voltage signal in time domain. This telegraphic noise is used to find the mean lifetime of each of the two states. The mean life time in the zero voltage state is found to decrease with increasing bias current while that of resistive state increases and thus the two cross at certain bias current. We qualitatively discuss this observed switching behavior as arising from the bi-stable nature.

  12. Fibronectin Rigidity Response through Fyn and p130Cas Recruitment to the Leading Edge

    PubMed Central

    Kostic, Ana

    2006-01-01

    Cell motility on extracellular matrices critically depends on matrix rigidity, which affects cell adhesion and formation of focal contacts. Receptor-like protein tyrosine phosphatase alpha (RPTPα) and the αvβ3 integrin form a rigidity-responsive complex at the leading edge. Here we show that the rigidity response through increased spreading and growth correlates with leading edge recruitment of Fyn, but not endogenous c-Src. Recruitment of Fyn requires the palmitoylation site near the N-terminus and addition of that site to c-Src enables it to support a rigidity response. In all cases, the rigidity response correlates with the recruitment of the Src family kinase to early adhesions. The stretch-activated substrate of Fyn and c-Src, p130Cas, is also required for a rigidity response and it is phosphorylated at the leading edge in a Fyn-dependent process. A possible mechanism for the fibronectin rigidity response involves force-dependent Fyn phosphorylation of p130Cas with rigidity-dependent displacement. With the greater displacement of Fyn from p130Cas on softer surfaces, there will be less phosphorylation. These studies emphasize the importance of force and nanometer-level movements in cell growth and function. PMID:16597701

  13. Stabilization of the permanent rotations of a rigid body

    NASA Astrophysics Data System (ADS)

    Biiarov, T.; Krementulo, V. V.; Tazhekov, A.

    1991-08-01

    The problem of stabilization of the equilibrium and permanent rotations of a heavy rigid body with a fixed point is solved in the classical cases of Euler, Lagrange, and Kovalevskaya using methods of analytical control theory. In the above cases, the control moments obtained in explicit form provide for the asymptotic stability of the permanent rotation on the whole. The control moments are selected in the form of linear functions with respect to perturbations.

  14. Coiling of elastic rods on rigid substrates

    PubMed Central

    Jawed, Mohammad K.; Da, Fang; Joo, Jungseock; Grinspun, Eitan; Reis, Pedro M.

    2014-01-01

    We investigate the deployment of a thin elastic rod onto a rigid substrate and study the resulting coiling patterns. In our approach, we combine precision model experiments, scaling analyses, and computer simulations toward developing predictive understanding of the coiling process. Both cases of deposition onto static and moving substrates are considered. We construct phase diagrams for the possible coiling patterns and characterize them as a function of the geometric and material properties of the rod, as well as the height and relative speeds of deployment. The modes selected and their characteristic length scales are found to arise from a complex interplay between gravitational, bending, and twisting energies of the rod, coupled to the geometric nonlinearities intrinsic to the large deformations. We give particular emphasis to the first sinusoidal mode of instability, which we find to be consistent with a Hopf bifurcation, and analyze the meandering wavelength and amplitude. Throughout, we systematically vary natural curvature of the rod as a control parameter, which has a qualitative and quantitative effect on the pattern formation, above a critical value that we determine. The universality conferred by the prominent role of geometry in the deformation modes of the rod suggests using the gained understanding as design guidelines, in the original applications that motivated the study. PMID:25267649

  15. Rigid shells enhance survival of gekkotan eggs.

    PubMed

    Andrews, Robin M

    2015-11-01

    The majority of lizards and snakes produce permeable parchment-shelled eggs that require high moisture conditions for successful embryonic development. One clade of gekkotan lizards is an exception; females produce relatively impermeable rigid-shelled eggs that normally incubate successfully under low moisture conditions. I tested the hypothesis that the rigid-shell increases egg survival during incubation, but only under low moisture conditions. To test this hypothesis, I incubated rigid-shelled eggs of Chondrodactylus turneri under low and under high moisture conditions. Eggs were incubated with parchment-shelled eggs of Eublepharis macularius to insure that incubation conditions were suitable for parchment-shelled eggs. Chondrodactylus turneri eggs had very high survival (>90%) when they were incubated under low moisture conditions. In contrast, eggs incubated under high moisture conditions had low survival overall, and lower survival than those of the parchment-shelled eggs of E. macularius. Mortality of C. turneri and E. macularius eggs incubated under high moisture conditions was the result of fungal infection, a common source of egg mortality for squamates under laboratory and field conditions. These observations document high survival of rigid-shelled eggs under low moisture conditions because eggs escape from fungal infection. Highly mineralized rigid shells also make egg survival independent of moisture availability and may also provide protection from small invertebrates in nature. Enhanced egg survival could thus compensate for the low reproductive output of gekkotans that produce rigid-shelled eggs.

  16. Angled rigid neuroendoscope for continuous intraoperative visual monitoring: technical note.

    PubMed

    Tamaki, N; Hara, Y; Takaishi, Y; Shimada, S

    2001-03-01

    We developed and tested a new, angled rigid endoscope as a tool for performing continuous visual monitoring during microsurgery. The shaft of the scope is angled 110 degrees at its midportion using a prism. We used the scope continuously in 30 cases including 15 pituitary tumours, 7 brain tumours, 7 cerebral aneurysms, and one hemifacial spasm. For pituitary tumours the tip of the scope was positioned in the sphenoid sinus or in the cavity formed by tumour removal; for cerebral aneurysms it was placed behind the parent artery or the aneurysmal neck. Image quality was acceptable for intraoperative monitoring. In no case did the neuroendoscope have a deleterious impact on th e proper function of the microscope or surgical instruments. This angled rigid scope was more effective for intraoperative monitoring than conventional straight scopes. PMID:11243766

  17. First-passage time in a bistable potential with colored noise

    SciTech Connect

    Ramirez-Piscina, L.; Maria Sancho, J.; Javier de la Rubia, F.; Lindenberg, K.; Tsironis, G. P.

    1989-08-15

    A precise digital simulation of a bistable system under the effect of colored noise is carried out. A set of data for the mean first-passage time is obtained. The results are interpreted and compared with presently available theories, which are revisited following a new insight. Discrepancies that have been discussed in the literature are understood within our framework.

  18. A composite beam with dual bistability for enhanced vibration energy harvesting

    NASA Astrophysics Data System (ADS)

    Harris, Peter; Litak, Grzegorz; Bowen, Chris R.; Arafa, Mustafa

    2016-05-01

    In this paper a bistable composite cantilever beam comprising asymmetric laminates is studied for vibration energy harvesting applications. An additional magnetic bistability is introduced to the harvesting system to lower the level of excitation that triggers the snap-through for the cantilever from one stable state to another, while retaining the favorable broadband performance. In order to achieve the, the cantilever beam is fitted with a permanent magnet at its tip that is oriented so that there is magnetic repulsion with a stationary magnet. The system performance can be adjusted by varying the separation between the magnets. Experimental results reveal that the use of magnetic bistability enhances broadband performance and improves the output power within a certain level of drive level and magnet separation. The load-deflection characteristic of the bistable beam is experimentally determined, and is subsequently used to model the system by a reduced single-degree-of-freedom (SDOF) system having the form of the Duffing equation for a double-well potential system. The dynamics of the beam are investigated using bifurcation diagrams and shows that the qualitative behavior given by the experimentally measured response is predicted well by the simple SDOF model.

  19. Deterministic and Stochastic Modeling of an Artificial Bistable Switch in E. coli

    NASA Astrophysics Data System (ADS)

    Finkelstein, Daniel; Buchler, Nicolas; Karapetyan, Sargis

    Networks of mutually interacting genes are common in natural regulatory networks. To better understand these interactions, scientists have recently been constructing artificial genetic networks. Much of the effort is focused on creating genetic oscillators and bistable switches. In this project, we analyzed the possibility to create a bistable switch in E. coli. In this realization of the switch, the Repressor (basic leucine zipper CEBP/alpha) represses the transcription of the Inhibitor (artificial dominant negative 3HF). The Inhibitor, in turn, sequesters the Repressor by binding to it. Using deterministic modeling we identified a range of parameters suitable for bistability. We then analyzed the resulting solutions with the full model taking the reaction rates corresponding to E. coli and the including stochastic nature of gene expression. We have shown that the bistability in not destroyed by stochastic fluctuations if several copies of genes are present. Specifically, taking a realistic number of plasmids (10) we show that the number of proteins in the systems undergoes sizable fluctuations; however, the two states with low and high concentrations of inhibitor stay distinct in the relevant range of parameters.

  20. Critical slowing down and critical exponents in LD/PIN optically-bistable semiconductor lasers

    SciTech Connect

    Zhong Lichen; Guo Yili

    1988-04-01

    Critical slowing down for LD/PIN bistable optical semiconductor lasers and the critical exponents ..gamma.. for this system have been experimentally investigated. The experimental value ..gamma..approx.0.53 is basically in agreement with the theoretically predicted value of 0.5.

  1. Low threshold optical bistability at terahertz frequencies with graphene surface plasmons

    NASA Astrophysics Data System (ADS)

    Dai, Xiaoyu; Jiang, Leyong; Xiang, Yuanjiang

    2015-07-01

    We propose a modified Kretschmann-Raether configuration to realize the low threshold optical bistable devices at the terahertz frequencies. The metal layer is replaced by the dielectric sandwich structure with the insertion of graphene, and this configuration can support TM-polarization surface electromagnetic wave. The surface plasmon resonance is strongly dependent on the Fermi-level of graphene and the thickness of the sandwich structure. It is found that the switching-up and switching-down intensities required to observe the optical bistable behavior are lowered markedly due to the excitation of the graphene surface plasmons, thus making this configuration a prime candidate for experimental investigation at the terahertz range. And the switching threshold value can be further reduced by decreasing the Fermi-level or increasing the thickness of sandwich structure, hence providing a new way for realizing tunable optical bistable devices. Finally, the optical bistability at higher terahertz frequency and the influence of relaxation time under the actual experimental condition on Fermi-level are discussed.

  2. Implications of the spatial dynamics of fire spread for the bistability of savanna and forest.

    PubMed

    Schertzer, E; Staver, A C; Levin, S A

    2015-01-01

    The role of fire in expanding the global distribution of savanna is well recognized. Empirical observations and modeling suggest that fire spread has a threshold response to fuel-layer continuity, which sets up a positive feedback that maintains savanna-forest bistability. However, modeling has so far failed to examine fire spread as a spatial process that interacts with vegetation. Here, we use simple, well-supported assumptions about fire spread as an infection process and its effects on trees to ask whether spatial dynamics qualitatively change the potential for savanna-forest bistability. We show that the spatial effects of fire spread are the fundamental reason that bistability is possible: because fire spread is an infection process, it exhibits a threshold response to fuel continuity followed by a rapid increase in fire size. Other ecological processes affecting fire spread may also contribute including temporal variability in demography or fire spread. Finally, including the potential for spatial aggregation increases the potential both for savanna-forest bistability and for savanna and forest to coexist in a landscape mosaic.

  3. Bi-stable states of initially stressed elastic cylindrical shell structures with two piezoelectric surface layers

    NASA Astrophysics Data System (ADS)

    Wang, Bin; Nie, Guo-Hua

    2015-10-01

    A theoretical model is proposed in this paper to predict the bi-stable states of initially stressed cylindrical shell structures attached by surface anisotropic piezoelectric layers. The condition for existence of bi-stability of the shell structural system is presented and analytical expressions for corresponding rolled-up radii of the stable shell are given based on the principle of minimum strain energy. The resulting solution indicates that the shell system may have two stable configurations besides its initial state under a combined action of the actuating electric field and initial stresses characterized by the bending moment. If the piezoelectric layer materials act as only sensor materials without the actuating electric field, initial stresses may produce the bi-stable states, but one corresponding to its initial state. For the shell without initial stresses, the magnitude in the actuating electric field determines the number of the stable states, one or two stable configurations besides the initial state. The theoretical prediction for the bi-stable states is verified by finite element method (FEM) simulation by using the ABAQUS code.

  4. Low threshold optical bistability at terahertz frequencies with graphene surface plasmons

    PubMed Central

    Dai, Xiaoyu; Jiang, Leyong; Xiang, Yuanjiang

    2015-01-01

    We propose a modified Kretschmann-Raether configuration to realize the low threshold optical bistable devices at the terahertz frequencies. The metal layer is replaced by the dielectric sandwich structure with the insertion of graphene, and this configuration can support TM-polarization surface electromagnetic wave. The surface plasmon resonance is strongly dependent on the Fermi-level of graphene and the thickness of the sandwich structure. It is found that the switching-up and switching-down intensities required to observe the optical bistable behavior are lowered markedly due to the excitation of the graphene surface plasmons, thus making this configuration a prime candidate for experimental investigation at the terahertz range. And the switching threshold value can be further reduced by decreasing the Fermi-level or increasing the thickness of sandwich structure, hence providing a new way for realizing tunable optical bistable devices. Finally, the optical bistability at higher terahertz frequency and the influence of relaxation time under the actual experimental condition on Fermi-level are discussed. PMID:26194273

  5. Rigidity Dependence of Cosmic Ray Modulation

    NASA Astrophysics Data System (ADS)

    Agarwal Mishra, Rekha; Mishra, Rajesh Kumar

    2012-07-01

    The various observed harmonics of the cosmic ray variation may be understood on a unified basis if the free space cosmic ray anisotropy is non-sinusoidal in form. The major objective of this paper is to study the first three harmonics of cosmic ray intensity on geo-magnetically quiet days over the period 1965-1990 for Deep River, Goose Bay and Tokyo neutron monitoring stations. The amplitude of first harmonic remains high for Deep River having low cutoff rigidity as compared to Tokyo neutron monitor having high cutoff rigidity on quiet days. The diurnal amplitude significantly decreases in 1987 at Deep River and in 1986 at Tokyo during solar activity minimum years. The diurnal time of maximum significantly shifts to an earlier time as compared to the corotational direction at both the stations having different cutoff rigidities. The time of maximum for first harmonic significantly shifts towards later hours and for second harmonic it shifts towards earlier hours at low cutoff rigidity station i.e. Deep River as compared to the high cut off rigidity station i.e. Tokyo on quiet days. The amplitude of second/third harmonics shows a good positive correlation with solar wind velocity, while the others (i.e. amplitude and phase) have no significant correlation on quiet days. The solar wind velocity significantly remains in the range 350 to 425 km/s i.e. being nearly average on quiet days. The amplitude and direction of the anisotropy on quiet days are weakly dependent on high-speed solar wind streams for these neutron monitoring stations of low and high cutoff rigidity threshold. Keywords: cosmic ray, cut off rigidity, quiet days, harmonics.

  6. Influence of ZnO nanostructures in liquid crystal interfaces for bistable switching applications

    NASA Astrophysics Data System (ADS)

    Pal, Kaushik; Zhan, Bihong; Madhu Mohan, M. L. N.; Schirhagl, Romana; Wang, Guoping

    2015-12-01

    The controlled fabrication of nanometer-scale objects is without doubt one of the central issues in current science and technology. In this article, we exhibit a simple, one-step bench top synthesis of zinc oxide nano-tetrapods and nano-spheres which were tailored by the facial growth of nano-wires (diameter ≈ 24 nm; length ≈ 118 nm) and nano-cubes (≈395 nm edge) to nano-sphere (diameter ≈ 585 nm) appeaded. The possibilities of inexpensive, simple solvo-chemical synthesis of nanostructures were considered. In this article, a successful attempt has been made that ZnO nano-structures dispersed on well aligned hydrogen bonded liquid crystals (HBLC) comprising azelaic acid (AC) with p-n-alkyloxy benzoic acid (nBAO) by varying the respective alkyloxy carbon number (n = 5). The dispersion of nanomaterials with HBLC is an effective route to enhance the existing functionalities. A series of these composite materials were analyzed by polarizing optical microscope's electro-optical switching. An interesting feature of AC + nBAO is the inducement of tilted smectic G phase with increasing carbon chain length. Phase diagrams of the above hybrid ZnO nanomaterial influenced LC complex and pure LC were constructed and compared. The switching times, the contrast ratio and spontaneous polarization of the nanostructures-HBLC composite film were carried out by systematic investigation. The sample preparation parameters, such as the curing time and curing intensity were optimized. The critical applied voltage to achieve the switching bi-stability of our device is only 4.5 V, which is approximately twice its threshold voltage for Freedericksz transition. This performance puts the hybrid structure at the top level in the state of the art in application oriented research in optics of liquid crystalline composite materials.

  7. Mechanisms generating bistability and oscillations in microRNA-mediated motifs

    NASA Astrophysics Data System (ADS)

    Zhou, Peipei; Cai, Shuiming; Liu, Zengrong; Wang, Ruiqi

    2012-04-01

    The importance of post-transcriptional regulation by microRNAs (miRNAs) has recently been recognized in almost all cellular processes. When participating in cellular processes, miRNAs mainly mediate mRNA degradation or translational repression. Recently computational and experimental studies have identified an abundance of motifs involving miRNAs and transcriptional factors (TFs). The simplest motif is a two-node miRNA-mediated feedback loop (MFL) in which a TF regulates an miRNA and the TF itself is negatively regulated by the miRNA. In this paper we present a general computational model for the MFL based on biochemical regulations and explore its dynamics by using bifurcation analysis. Our results show that the MFL can behave either as switches or as oscillators, depending on the TF as a repressor or an activator. These functional features are consistent with the widespread appearance of miRNAs in fate decisions such as proliferation, differentiation, and apoptosis during development. We found that under the interplay of a TF and an miRNA, the MFL model can behave as switches for wide ranges of parameters even without cooperative binding of the TF. In addition, oscillations induced by the miRNA in the MFL model require neither an additional positive feedback loop, nor self-activation of the gene, nor cooperative binding of the TF, nor saturated degradation. Therefore, the MFL may provide a general network structure to induce bistability or oscillations. It is hoped that the results presented here will provide a new view on how gene expression is regulated by miRNAs and further guidance for experiments. Moreover, the insight gained from this study is also expected to provide a basis for the investigation of more complex networks assembled by simple building blocks.

  8. Multiscale multiphysics and multidomain models—Flexibility and rigidity

    SciTech Connect

    Xia, Kelin; Opron, Kristopher; Wei, Guo-Wei

    2013-11-21

    The emerging complexity of large macromolecules has led to challenges in their full scale theoretical description and computer simulation. Multiscale multiphysics and multidomain models have been introduced to reduce the number of degrees of freedom while maintaining modeling accuracy and achieving computational efficiency. A total energy functional is constructed to put energies for polar and nonpolar solvation, chemical potential, fluid flow, molecular mechanics, and elastic dynamics on an equal footing. The variational principle is utilized to derive coupled governing equations for the above mentioned multiphysical descriptions. Among these governing equations is the Poisson-Boltzmann equation which describes continuum electrostatics with atomic charges. The present work introduces the theory of continuum elasticity with atomic rigidity (CEWAR). The essence of CEWAR is to formulate the shear modulus as a continuous function of atomic rigidity. As a result, the dynamics complexity of a macromolecular system is separated from its static complexity so that the more time-consuming dynamics is handled with continuum elasticity theory, while the less time-consuming static analysis is pursued with atomic approaches. We propose a simple method, flexibility-rigidity index (FRI), to analyze macromolecular flexibility and rigidity in atomic detail. The construction of FRI relies on the fundamental assumption that protein functions, such as flexibility, rigidity, and energy, are entirely determined by the structure of the protein and its environment, although the structure is in turn determined by all the interactions. As such, the FRI measures the topological connectivity of protein atoms or residues and characterizes the geometric compactness of the protein structure. As a consequence, the FRI does not resort to the interaction Hamiltonian and bypasses matrix diagonalization, which underpins most other flexibility analysis methods. FRI's computational complexity is of O

  9. Control of optical bistability and third-order nonlinearity via tunneling induced quantum interference in triangular quantum dot molecules

    SciTech Connect

    Tian, Si-Cong Tong, Cun-Zhu Zhang, Jin-Long; Shan, Xiao-Nan; Fu, Xi-Hong; Zeng, Yu-Gang; Qin, Li; Ning, Yong-Qiang; Wan, Ren-Gang

    2015-06-15

    The optical bistability of a triangular quantum dot molecules embedded inside a unidirectional ring cavity is studied. The type, the threshold and the hysteresis loop of the optical bistability curves can be modified by the tunneling parameters, as well as the probe laser field. The linear and nonlinear susceptibilities of the medium are also studied to interpret the corresponding results. The physical interpretation is that the tunneling can induce the quantum interference, which modifies the linear and the nonlinear response of the medium. As a consequence, the characteristics of the optical bistability are changed. The scheme proposed here can be utilized for optimizing and controlling the optical switching process.

  10. Scratch resistance of rigid contact lens materials.

    PubMed

    Tranoudis, I; Efron, N

    1996-07-01

    Practitioners have long recognised the importance of determining the extent of scratching on the surface of rigid contact lenses when deciding on lens replacement. Despite this, little research has been undertaken to define this problem. The extent of scratching of rigid contact lens materials was evaluated and this property was related to material oxygen permeability and refractive index. One hundred and forty lenses made from 28 different rigid materials were evaluated in a masked and randomised manner. Scratches were created on the front surface of the lenses using an apparatus that was specifically designed and constructed for this experiment. The extent of scratching was quantitatively evaluated using a computer-based scanning and image analysis system. The oxygen permeability of all materials was measured using the polarographic method. An Atago N3000 hand-held refractometer was used to measure the refractive index of these materials. Three significant correlations were revealed: an inverse relationship (r = -0.813, P < 0.0001) between oxygen permeability and refractive index; a positive relationship (r = 0.511, P < 0.008) between oxygen permeability and the extent of scratching; and an inverse relationship (r = -0.539, P < 0.0058) between refractive index and the extent of scratching. The information generated in this study concerning scratch resistance of rigid contact-lens materials may assist the contact lens industry and contact lens practitioners in developing and prescribing rigid lenses with optimal performance characteristics.

  11. 49 CFR 178.706 - Standards for rigid plastic IBCs.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 3 2012-10-01 2012-10-01 false Standards for rigid plastic IBCs. 178.706 Section... Performance-Oriented Standards § 178.706 Standards for rigid plastic IBCs. (a) The provisions in this section apply to rigid plastic IBCs intended to contain solids or liquids. Rigid plastic IBC types...

  12. 49 CFR 178.706 - Standards for rigid plastic IBCs.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 3 2014-10-01 2014-10-01 false Standards for rigid plastic IBCs. 178.706 Section... Performance-Oriented Standards § 178.706 Standards for rigid plastic IBCs. (a) The provisions in this section apply to rigid plastic IBCs intended to contain solids or liquids. Rigid plastic IBC types...

  13. 49 CFR 178.706 - Standards for rigid plastic IBCs.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 3 2011-10-01 2011-10-01 false Standards for rigid plastic IBCs. 178.706 Section... Performance-Oriented Standards § 178.706 Standards for rigid plastic IBCs. (a) The provisions in this section apply to rigid plastic IBCs intended to contain solids or liquids. Rigid plastic IBC types...

  14. 49 CFR 178.706 - Standards for rigid plastic IBCs.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... apply to rigid plastic IBCs intended to contain solids or liquids. Rigid plastic IBC types are... equipment designed to withstand the whole load when IBCs are stacked, for liquids. (6) 31H2 freestanding, for liquids. (b) Rigid plastic IBCs consist of a rigid plastic body, which may have...

  15. 49 CFR 178.706 - Standards for rigid plastic IBCs.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... in this section apply to rigid plastic IBCs intended to contain solids or liquids. Rigid plastic IBC... structural equipment designed to withstand the whole load when IBCs are stacked, for liquids. (6) 31H2 freestanding, for liquids. (b) Rigid plastic IBCs consist of a rigid plastic body, which may have...

  16. Quantum mechanics of a generalised rigid body

    NASA Astrophysics Data System (ADS)

    Gripaios, Ben; Sutherland, Dave

    2016-05-01

    We consider the quantum version of Arnold’s generalisation of a rigid body in classical mechanics. Thus, we quantise the motion on an arbitrary Lie group manifold of a particle whose classical trajectories correspond to the geodesics of any one-sided-invariant metric. We show how the derivation of the spectrum of energy eigenstates can be simplified by making use of automorphisms of the Lie algebra and (for groups of type I) by methods of harmonic analysis. We show how the method can be extended to cosets, generalising the linear rigid rotor. As examples, we consider all connected and simply connected Lie groups up to dimension 3. This includes the universal cover of the archetypical rigid body, along with a number of new exactly solvable models. We also discuss a possible application to the topical problem of quantising a perfect fluid.

  17. Generic Rigidity for Circle Diffeomorphisms with Breaks

    NASA Astrophysics Data System (ADS)

    Kocić, Saša

    2016-06-01

    We prove that {C^r}-smooth ({r > 2}) circle diffeomorphisms with a break, i.e., circle diffeomorphisms with a single singular point where the derivative has a jump discontinuity, are generically, i.e., for almost all irrational rotation numbers, not {C^{1+\\varepsilon}}-rigid, for any {\\varepsilon > 0}. This result complements our recent proof, joint with Khanin (Geom Funct Anal 24:2002-2028, 2014), that such maps are generically {C^1}-rigid. It stands in remarkable contrast to the result of Yoccoz (Ann Sci Ec Norm Sup 17:333-361, 1984) that {C^r}-smooth circle diffeomorphisms are generically {C^{r-1-κ}}-rigid, for any {κ > 0}.

  18. How substrate rigidity regulates the cellular motility

    NASA Astrophysics Data System (ADS)

    Sarvestani, Alireza

    2011-03-01

    Mechanical stiffness of bio-adhesive substrates has been recognized as a major regulator of cell motility. We present a simple physical model to study the crawling locomotion of a contractile cell on a soft elastic substrate. The mechanism of rigidity sensing is accounted for using Schwarz's two spring model (Schwarz et al. (2006) BioSystems 83, 225-232). The predicted dependency between the speed of motility and substrate stiffness is qualitatively consistent with experimental observations. The model demonstrates that the rigidity dependent motility of cells is rooted in the regulation of actomyosin contractile forces by substrate deformation at each anchorage point. On stiffer substrates, the traction forces required for cell translocation acquire larger magnitude but show weaker asymmetry which leads to slower cell motility. On very soft substrates, the model predicts a biphasic relationship between the substrate rigidity and the speed of locomotion, over a narrow stiffness range, which has been observed experimentally for some cell types.

  19. Dielectric elastomer bending tube actuators with rigid electrode structures

    NASA Astrophysics Data System (ADS)

    Wehrheim, F.; Schlaak, H. F.; Meyer, J.-U.

    2010-04-01

    The common approach for dielectric elastomer actuators (DEA) is based on the assumption that compliant electrodes are a fundamental design requirement. For tube-like applications compliant electrodes cause a change of the actuator diameter during actuation and would require additional support-structures. Focused on thinwalled actuator-tube geometries room consumption and radial stabilityr epresent crucial criteria. Following the ambition of maximum functional integration, the concept of using a rigid electrode structure arises. This structure realizes both, actuation and support characteristics. The intended rigid electrode structure is based on a stacked DEA with a non-compressible dielectric. Byactu ation, the displaced dielectric causes an overlap. This overlap serves as an indicator for geometrical limitations and has been used to extract design rules regarding the electrode size, electrode distance and maximum electrode travel. Bycons idering the strain in anydir ection, the mechanical efficiencyhas been used to define further design aspects. To verifyt he theoretic analysis, a test for determination of the compressive stress-strain-characteristics has been applied for different electrode setups. As result the geometrydep ending elastic pressure module has been formulated by implementation of a shape factor. The presented investigations consider exclusive the static behavior of a DEA-setup with rigid electrodes.

  20. Rigidity and retention of ceramic root canal posts.

    PubMed

    Purton, D G; Love, R M; Chandler, N P

    2000-01-01

    Ceramic root-canal posts offer potential advantages over other types with respect to aesthetics and biocompatibility. Any post must be sufficiently rigid and retentive to withstand functional forces. Ceraposts (1.2 mm coronal diameter, ceramic, tapering, smooth posts) and Paraposts (1.25 mm, stainless-steel, parallel, serrated posts) were tested for rigidity by means of a three-point bending test. To test retention in roots, ceramic posts were cemented using one of three protocols: (1) glass-ionomer cement, (2) silane coupling agent and resin cement, or (3) sandblasted post surface, silane coupling agent, and resin cement. Stainless-steel posts were cemented with resin. The tensile force required to dislodge the posts, following four weeks of storage in water, was recorded. Data were compared using Student's t-test and Mann-Whitney U analysis. Ceraposts were significantly more rigid than Paraposts (p < 0.001). Paraposts cemented with resin were significantly more strongly retained than Ceraposts following any cementation protocol (p < 0.001). Retention of the ceramic posts was significantly greater with a silane coupling agent and resin cement than with glass-ionomer cement (p < 0.001). Sandblasting the ceramic posts produced variable results and needs further investigation before it could be recommended.

  1. Theory of rigid-plane phonon modes in layered crystals

    NASA Astrophysics Data System (ADS)

    Michel, K. H.; Verberck, B.

    2012-03-01

    The lattice dynamics of low-frequency rigid-plane modes in metallic (graphene multilayers, GML) and in insulating (hexagonal boron-nitride multilayers, BNML) layered crystals is investigated. The frequencies of shearing and compression (stretching) modes depend on the layer number N and are presented in the form of fan diagrams. The results for GML and BNML are very similar. In both cases, only the interactions (van der Waals and Coulomb) between nearest-neighbor planes are effective, while the interactions between more distant planes are screened. A comparison with recent Raman scattering results on low-frequency shear modes in GML [Tan , Nat. Mater., in press, doi:10.1038/nmat3245, (2012)] is made. Relations with the low-lying rigid-plane phonon dispersions in the bulk materials are established. Master curves, which connect the fan diagram frequencies for any given N, are derived. Static and dynamic thermal correlation functions for rigid-layer shear and compression modes are calculated. The results might be of use for the interpretation of friction force experiments on multilayer crystals.

  2. Rigidity and retention of ceramic root canal posts.

    PubMed

    Purton, D G; Love, R M; Chandler, N P

    2000-01-01

    Ceramic root-canal posts offer potential advantages over other types with respect to aesthetics and biocompatibility. Any post must be sufficiently rigid and retentive to withstand functional forces. Ceraposts (1.2 mm coronal diameter, ceramic, tapering, smooth posts) and Paraposts (1.25 mm, stainless-steel, parallel, serrated posts) were tested for rigidity by means of a three-point bending test. To test retention in roots, ceramic posts were cemented using one of three protocols: (1) glass-ionomer cement, (2) silane coupling agent and resin cement, or (3) sandblasted post surface, silane coupling agent, and resin cement. Stainless-steel posts were cemented with resin. The tensile force required to dislodge the posts, following four weeks of storage in water, was recorded. Data were compared using Student's t-test and Mann-Whitney U analysis. Ceraposts were significantly more rigid than Paraposts (p < 0.001). Paraposts cemented with resin were significantly more strongly retained than Ceraposts following any cementation protocol (p < 0.001). Retention of the ceramic posts was significantly greater with a silane coupling agent and resin cement than with glass-ionomer cement (p < 0.001). Sandblasting the ceramic posts produced variable results and needs further investigation before it could be recommended. PMID:11203820

  3. Measuring membrane rigidity and viscosity: New methods, and new insights

    NASA Astrophysics Data System (ADS)

    Parthasarathy, Raghuveer

    2014-03-01

    Lipid membranes are remarkable materials: flexible, two-dimensional fluids whose physical properties guide cellular function. Bending rigidity and viscosity are two of the key mechanical parameters that characterize membranes. Both, however, are challenging to measure. I describe improvements in experimental techniques to quantify the bending modulus and the two-dimensional viscosity of lipid membranes. First, I show that using selective plane illumination microscopy (SPIM, also known as light sheet fluorescence microscopy) to image the thermal fluctuations of freely suspended giant lipid vesicles enables straightforward measurements of membrane rigidity, and also provides insights into changes in rigidity induced by cargo trafficking proteins. Second, I show that tracking both the rotational and translational diffusion of membrane-anchored tracer particles allows quantification of membrane viscosity, measurement of the effective radii of the tracers, and assessment of theoretical models of membrane hydrodynamics. Surprisingly, we find a wide distribution of effective tracer sizes, due presumably to a wide variety of couplings to the membrane. I also provide an example of protein-mediated changes in lipid viscosity.

  4. Service life evaluation of rigid explosive transfer lines

    NASA Technical Reports Server (NTRS)

    Bement, L. J.; Kayser, E. G.; Schimmel, M. L.

    1983-01-01

    This paper describes a joint Army/NASA-sponsored research program on the service life evaluation of rigid explosive transfer lines. These transfer lines are used to initiate emergency crew escape functions on a wide variety of military and NASA aircraft. The purpose of this program was to determine quantitatively the effects of service, age, and degradation on rigid explosive transfer lines to allow responsible, conservative, service life determination. More than 800 transfer lines were removed from the U.S. Army AH-1G and AH-1S, the U.S. Air Force B-1 and F-111, and the U.S. Navy F-14 aircraft for testing. The results indicated that the lines were not adversely affected by age, service, or a repeat of the thermal qualification tests on full-service lines. Extension of the service life of rigid explosive transfer lines should be considered, since considerable cost savings could be realized with no measurable decrease in system reliability.

  5. Coarse-grained rigid blob model for soft matter simulations

    NASA Astrophysics Data System (ADS)

    Chao, Sheng D.; Kress, Joel D.; Redondo, Antonio

    2005-06-01

    We have developed a coarse-grained multiscale molecular simulation method for soft matter systems that directly incorporates stereochemical information. We divide the material into disjoint groups of atoms or particles that move as separate rigid bodies; we call these groups "rigid blobs," hence the name coarse-grained rigid blob model. The method is enabled by the construction of transferable interblob potentials that approximate the net intermolecular interactions, as obtained from ab initio electronic structure calculations, other all-atom empirical potentials, experimental data, or any combination of the above. We utilize a multipolar expansion to obtain the interblob potential-energy functions. The series, which contains controllable approximations that allow us to estimate the errors, approaches the original intermolecular potential as the number of terms increases. Using a novel numerical algorithm, we can calculate the interblob potentials very efficiently in terms of a few interaction moment tensors. This reduces the labor well beyond what is required in standard molecular-dynamics calculations and allows large-scale simulations for temporal scales commensurate with characteristic times of nano- and mesoscale systems. A detailed derivation of the formulas is presented, followed by illustrative applications to several systems showing that the method can effectively capture realistic microscopic details and can easily extend to large-scale simulations.

  6. Use of interseismic GPS data: a novel way to evaluate the lithosphere rigidity variations.

    NASA Astrophysics Data System (ADS)

    Furst, Severine; Peyret, Michel; Chéry, Jean; Mohammadi, Bijan

    2016-04-01

    Although the flexure of the lithosphere is well constrained using a simple secular cooling model in the ocean (Stewart and Watts, 1997), this mechanical parameter is not obvious to determine in the continents. One commonly estimates the flexural rigidity, expressed through the effective elastic thickness (Te) of the lithosphere, by studying the lithosphere's vertical motion induced by long-term geological loads. Here, we suggest a similar approach, using the horizontal velocities to evaluate lateral rigidity variations. To illustrate our method, we select the Western United States zone, where areas with high rigidity (Sierra Nevada) are connected with others displaying low rigidities (San Andreas Fault). Our technique is based on an inversion problem, aiming to infer the effective rigidity from interseismic strain distribution measured by geodetic methods. The forward problem is defined using the equations of linear elasticity in a plane stress finite element code. This method involves the minimisation of a cost function defined as the quadratic measure of the differences between measured and modeled velocity fields on a discrete set of points. Gradient of the functional, with respect to the independent parameters of the model, is computed using an adjoint formulation. Thanks to this construction, the mapping of the rigidity can be fulfilled with a large number of parameters. The optimisation chart is validated first on synthetic velocity data sets corresponding to the surface motion of a screw dislocation with different locking depths. Then, the effective rigidity variations of the Western United States are estimated using a dense geodetic network. The inversion displays low effective rigidities along the San Andreas Fault and in the Eastern California Shear zone, while rigid areas are found in the Sierra Nevada and in the South Basin and Range. High rigidity values are strongly correlated with regions presenting small deformations and vice-versa. In addition to

  7. Refractive index of rigid contact lens materials.

    PubMed

    Tranoudis, I; Efron, N

    1998-01-01

    A simple hand-held refractometer was used to measure the refractive index of 27 rigid gas permeable contact lens materials. As a general rule, lenses with refractive indices lower than 1.458 are made from fluorosilicone acrylates; lenses with refractive indices in the range of 1.458 to 1.469 are made from either fluorosilicone acrylates or silicone acrylates; and lenses with refractive indices greater than 1.469 are made from silicone acrylates. It is demonstrated how refractometry can be used by contact lens practitioners for the identification and verification of rigid contact lenses.

  8. Rigidity analysis of HIV-1 protease

    NASA Astrophysics Data System (ADS)

    Heal, J. W.; Wells, S. A.; Jimenez-Roldan, E.; Freedman, R. F.; Römer, R. A.

    2011-03-01

    We present a rigidity analysis on a large number of X-ray crystal structures of the enzyme HIV-1 protease using the 'pebble game' algorithm of the software FIRST. We find that although the rigidity profile remains similar across a comprehensive set of high resolution structures, the profile changes significantly in the presence of an inhibitor. Our study shows that the action of the inhibitors is to restrict the flexibility of the β-hairpin flaps which allow access to the active site. The results are discussed in the context of full molecular dynamics simulations as well as data from NMR experiments.

  9. Time-domain effects of rigid sphere scattering on measurement of transient plane waves.

    PubMed

    Muhlestein, Michael B; Thomas, Derek C; Gee, Kent L

    2014-07-01

    Transient waves, like all other acoustic waves, will diffract around solid objects, such as measurement instrumentation. A derivation of an impulse response function on the surface of a rigid sphere, based on linear, classical scattering theory, is presented. The theoretical impulse response function is validated using an experiment with blast noise. An application of the impulse response function to a rocket noise measurement is discussed. The impulse response function shows that the presence of the rigid sphere significantly affects the measurement and estimation of rocket-noise waveforms, power spectral densities, and statistical measures. PMID:24993191

  10. Switchable dielectric, piezoelectric, and second-harmonic generation bistability in a new improper ferroelectric above room temperature.

    PubMed

    Zhang, Yi; Ye, Heng-Yun; Cai, Hong-Ling; Fu, Da-Wei; Ye, Qiong; Zhang, Wen; Zhou, Qionghua; Wang, Jinlan; Yuan, Guo-Liang; Xiong, Ren-Gen

    2014-07-01

    Imidazolium periodate (IPI) is found to be an improper ferroelectric. It shows bistable properties simultaneously in three channels of dielectricity, piezoelectricity, and second-harmonic generation within the temperature window 300-310 K. PMID:24789577

  11. Origin of optical bistability and hysteretic reflectivity on account of nonlinearity at optically induced gallium silica interface

    NASA Astrophysics Data System (ADS)

    Sharma, Arvind; Nagar, A. K.

    2016-05-01

    The origin of optical bistability and hysterectic reflectivity on account of nonlinearity at optically induced Gallium silica interface has been investigated. Assuming the wave to be incident from the gallium nano particle layer side at gallium silica interface. The coupling between incident and reflected waves has shown nonlinear effects on Snell's law and Fresnel law. Effect of these nonlinear processes optical bistability and hysterectic reflectivity theoretically has been investigated. Theoretical results obtained are consistent with the available experimental results.

  12. Ultra-Low Threshold Optical Bistability and Multi-Stability in Dielecrtric Slab Doped with Semiconductor Quantum Well

    NASA Astrophysics Data System (ADS)

    Nasehi, R.

    2016-07-01

    A scheme for switching of the optical bistability (OB) and multi-stability (OM) in a dielectric slab doped with a three-level ladder-configuration n-doped semiconductor quantum well is simulated. It is shown that the bistable behavior of the system in dielectric slab can be controlled via amplitude or relative phase of applied fields. This optical system may provide some new possibilities for test the switching process.

  13. Observation of Optical Bistability and Multi-Stability in the Dielecrtric Slab Doped with a Quantum well Waveguide

    NASA Astrophysics Data System (ADS)

    Nasehi, R.

    2016-08-01

    The optical bistability (OB) and multi-stability (OM) behavior in a dielectric slab medium doped with semiconductor quantum well nanostructure has been discussed by employing the spin coherence effect. It is shown that, by changing the relative phase of applied fields the bistable behavior switches from OB to OM or vice versa in a dielectric medium. The effect of the frequency detuning of laser fields on the OB and OM behavior are also discussed in this paper.

  14. A novel benzene quantitative analysis method using miniaturized metal ionization gas sensor and non-linear bistable dynamic system

    PubMed Central

    Tang, Xuxiang; Liu, Fuqi

    2015-01-01

    In this paper, a novel benzene quantitative analysis method utilizing miniaturized metal ionization gas sensor and non-linear bistable dynamic system was investigated. Al plate anodic gas-ionization sensor was installed for electrical current-voltage data measurement. Measurement data was analyzed by non-linear bistable dynamics system. Results demonstrated that this method realized benzene concentration quantitative determination. This method is promising in laboratory safety management in benzene leak detection. PMID:26218927

  15. A novel benzene quantitative analysis method using miniaturized metal ionization gas sensor and non-linear bistable dynamic system.

    PubMed

    Tang, Xuxiang; Liu, Fuqi

    2015-01-01

    In this paper, a novel benzene quantitative analysis method utilizing miniaturized metal ionization gas sensor and non-linear bistable dynamic system was investigated. Al plate anodic gas-ionization sensor was installed for electrical current-voltage data measurement. Measurement data was analyzed by non-linear bistable dynamics system. Results demonstrated that this method realized benzene concentration quantitative determination. This method is promising in laboratory safety management in benzene leak detection.

  16. Extension of service life of rigid transfer lines /SMDC/. [explosive components for aircraft escape systems

    NASA Technical Reports Server (NTRS)

    Bement, L. J.; Kayser, E. G.; Schimmel, M. L.

    1982-01-01

    The results of a life evaluation program on rigid explosive transfer lines, which are used to initiate aircraft emergency crew escape functions, are presented in order to provide quantitative information on rigid explosive transfer lines which can contribute to responsible, conservative, service life determinations. The program involved the development of a test methodology, testing of the three types of transfer lines in use in the U.S., testing of these lines following a repeat of the thermal test conducted in the original qualification, and conducting a degradation investigation. Results from the testing of more than 800 components showed that rigid explosive transfer lines were not affected by age, service, or a repeat of the thermal qualification tests on full-service lines. The explosive degradation limits were approximated and the mechanisms examined. It is concluded that the service lives of rigid explosive transfer lines should be considered for extension in order to provide cost savings and increased system reliability.

  17. Liquid is More Rigid than Solid in a High-Frequency Region

    NASA Astrophysics Data System (ADS)

    Hasegawa, Naoki; Yuge, Tatsuro; Shimizu, Akira

    2016-01-01

    We compare rigidity of materials in two phases, liquid and solid phases. As a measure of the rigidity, we employ the one characterizing how firmly the material is fixed by low density of pinning centers, such as impurities and rough surfaces of walls, against a weak force. Although a solid is more rigid than a liquid against a low-frequency force, we find that against a high-frequency force the liquid becomes more rigid than the solid of the same material. Since this result is derived from universal properties of a response function, it is valid for wide classes of materials, including quantum and classical systems and crystalline and amorphous solids. An instructive example is studied using nonequilibrium molecular dynamics simulations. We find that the frequency region in which a solid is more flexible than a liquid is not purely determined by intrinsic properties of the solid. It depends also on extrinsic factors such as the density of pinning centers.

  18. The interplay of multiple feedback loops with post-translational kinetics results in bistability of mycobacterial stress response

    PubMed Central

    Tiwari, Abhinav; Balázsi, Gábor; Gennaro, Maria Laura; Igoshin, Oleg A

    2011-01-01

    Bacterial persistence is the phenomenon in which a genetically identical fraction of a bacterial population can survive exposure to stress by reduction or cessation of growth. Persistence in mycobacteria has been recently linked to a stress-response network, consisting of the MprA/MprB two-component system and alternative sigma factor σE. This network contains multiple positive transcriptional feedback loops which may give rise to bistability, making it a good candidate for controlling the mycobacterial persistence switch. To analyze the possibility of bistability, we develop a method that involves decoupling of the network into transcriptional and post-translational interaction modules. As a result we reduce the dimensionality of the dynamical system and independently analyze input–output relations in the two modules to formulate a necessary condition for bistability in terms of their logarithmic gains. We show that neither the positive autoregulation in the MprA/MprB network nor the σE-mediated transcriptional feedback is sufficient to induce bistability in a biochemically realistic parameter range. Nonetheless, inclusion of the post-translational regulation of σE by RseA increases the effective cooperativity of the system, resulting in bistability that is robust to parameter variation. We predict that overexpression or deletion of RseA, the key element controlling the ultrasensitive response, can eliminate bistability. PMID:20733247

  19. Rigid polyurethane and kenaf core composite foams

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Rigid polyurethane foams are valuable in many construction applications. Kenaf is a bast fiber plant where the surface stem skin provides bast fibers whose strength-to-weight ratio competes with glass fiber. The higher volume product of the kenaf core is an under-investigated area in composite appli...

  20. Rigid body dynamics on the Poisson torus

    NASA Astrophysics Data System (ADS)

    Richter, Peter H.

    2008-11-01

    The theory of rigid body motion with emphasis on the modifications introduced by a Cardan suspension is outlined. The configuration space is no longer SO(3) but a 3-torus; the equivalent of the Poisson sphere, after separation of an angular variable, is a Poisson torus. Iso-energy surfaces and their bifurcations are discussed. A universal Poincaré section method is proposed.

  1. Anaesthetic implications of rigid spine syndrome.

    PubMed

    Jorgensen, B G; Laub, M; Knudsen, R H

    1999-01-01

    The perioperative management of a 14-year-old girl, suffering from the muscular disorder rigid spine syndrome, is presented. The anaesthetic implications with regard to possible difficult intubation, cardiac involvement, malignant hyperthermia, neuromuscular blocking agents, and postoperative recovery are discussed. PMID:10411775

  2. Phosphorescence and Energy Transfer in Rigid Solutions.

    ERIC Educational Resources Information Center

    Enciso, E.; Cabello, A.

    1980-01-01

    Describes an experiment which illustrates the general aspects of intermolecular energy transfer between triplet states in rigid solutions of organic compounds solved in an ethanol-ether mixture. Measurements of quenching and energy transfer processes are made using the chemicals of benzophenone and naphthalene. (CS)

  3. Bending rigidity of composite resin coating clasps.

    PubMed

    Ikebe, K; Kibi, M; Ono, T; Nokubi, T

    1993-12-01

    The purpose of this study is to examine the bending profiles of composite resin coating cast clasps. The cobalt-chromium alloy cast clasps were made using tapered wax pattern. Silane coupling method (Silicoater MD, Kulzer Co.) was used to attach composite resin to metal surface. The breakage and the bending rigidity of composite resin coating clasps were evaluated. Results were as follows: 1) After the repeated bending test to the tips of clasp arm at 10,000 times in 0.25 mm deflection, neither crack on composite resin surface nor separation at resin/metal interface was observed in any specimen. 2) There was no significant difference in the bending rigidity of clasp arms between before and after composite resin coating. From these results, it was demonstrated that the composite resin coating cast clasp was available in clinical cases and coating with composite resin had little influence on the bending rigidity of clasp arms. Therefore, it was suggested that our clasp designing and fabricating system to control the bending rigidity of clasp arms could be applied to composite resin coating clasps. PMID:8935086

  4. Rigid spinal muscular dystrophy and rigid spine syndrome: report of 7 children.

    PubMed

    Koul, Roshan; Al-Yarubi, Saif; Al-Kindy, Hussein; Al-Futaisi, Amna; Al-Thihli, Khalid; Chacko, Poovathoor Alexander; Sankhla, Dilip

    2014-11-01

    Seven children (5 male, 2 female) were seen over the last 16 years with rigid spine syndrome. Six children had rigid spinal muscular dystrophy (selenoprotein N1-related myopathy [SEPN1RM]) and 1 had myopathy associated with rigid spine. The main presenting complaint in all was difficulty in bending the spine. The diagnosis was made on clinical features and imaging of the paraspinal muscles. Muscle histopathology revealed minimal myopathic changes to severe muscle degeneration. Genetic testing, which was only available for the last case, for selenoprotein was negative.

  5. Vibrational higher-order resonances in an overdamped bistable system with biharmonic excitation

    NASA Astrophysics Data System (ADS)

    Chizhevsky, V. N.

    2014-10-01

    Experimental evidence of vibrational higher-order resonances in a bistable vertical-cavity surface-emitting laser driven by two harmonic signals with very different frequencies is reported. The phenomenon shows up in a parameter space (the dc current, the amplitude of the high-frequency signal) as well-defined structures with multiple local maxima at higher harmonics of the low-frequency signal. Such structures appear due to a strong suppression of higher harmonics for certain values of the high-frequency amplitude and the dc current. Complexity of the structures and the total number of the local maxima depend on the harmonic order k . The behavior of nonlinear distortion factor is also studied. The experimental results are in a good agreement with the numerical results which were obtained in the model of the bistable overdamped oscillator with biharmonic excitation.

  6. Electrical bistable devices using composites of zinc sulfide nanoparticles and poly-(N-vinylcarbazole)

    NASA Astrophysics Data System (ADS)

    Cao, Ya-Peng; Hu, Yu-Feng; Li, Jian-Tao; Ye, Hai-Hang; Lü, Long-Feng; Ning, Yu; Lu, Qi-Peng; Tang, Ai-Wei; Lou, Zhi-Dong; Hou, Yan-Bing; Teng, Feng

    2015-03-01

    N-dodecanethiol capped zinc sulfide (ZnS) nanocrystals were synthesized by the one-pot approach and blended with poly (N-vinylcarbazole) (PVK) to fabricate electrical bistable devices. The corresponding devices did exhibit electrical bistability and negative differential resistance (NDR) effects. A large ON/OFF current ratio of 104 at negative voltages was obtained by applying different amplitudes of sweeping voltage. The observed conductance switching and the negative differential resistance are attributed to the electric-field-induced charge transfer between the nanocrystals and the polymer, and the charge trapping/detrapping in the nanocrystals. Project supported by the National Natural Science Foundation of China (Grant No. 61377028), the Natural Science Funds for Distinguished Young Scholar, China (Grant No. 61125505), and the Fundamental Research Funds for the Central Universities, China (Grant No. 2014JBZ009).

  7. Optical Bistability with Two Serially Integrated InP-SOAs on a Chip

    NASA Astrophysics Data System (ADS)

    Plascak, Michael Edward

    Optical Bistability with Two Serially Integrated InP-SOAs on a Chip Thesis Advisor: Dr. Azad Siahmakoun A photonic switch using two series-connected, reverse-biased semiconductor optical amplifiers integrated onto a single device has been proposed and switching operation has been verified experimentally. The switching operates on two principles; an electrical bistability arising from the connection of two p-i-n structures in series, and the quantum confined Stark effect in reverse-biased multiple quantum well structures. The result is an electroabsorption modulation of the light through the SOAs due to the alternating voltage states. The system simultaneously produces outputs with both inverted and non-inverted hysteresis behavior, with experimental switching speeds demonstrated up to 400 kHz for a reverse-bias voltage of VRB=2.000V.

  8. Controllable optical bistability in a cavity optomechanical system with a Bose-Einstein condensate

    NASA Astrophysics Data System (ADS)

    Hamideh Kazemi, Seyedeh; Ghanbari, Saeed; Mahmoudi, Mohammad

    2016-05-01

    The optical bistability (OB) in a two-mode optomechanical system with a Bose-Einstein condensate (BEC) is studied. By investigating the behavior of steady state solutions, we show that how OB develops in the system for a certain range of cavity-pump detunings and pump amplitudes. We then investigate the effects of the decay rate of the cavity photons and coupling strength between the cavity and the BEC as well as the pump-atom detuning on the optical behaviour of the system. We find that one can control the OB threshold and width of the bistability curve via adjusting properly the coupling strength and the detuning. By applying Routh-Hurwitz criterion, we then derive stability conditions for different branches of the OB curve. Moreover, by introducing an effective potential for the system, a simple physical interpretation is obtained.

  9. Bistability in self-activating genes regulated by non-coding RNAs

    NASA Astrophysics Data System (ADS)

    Miro-Bueno, Jesus

    2015-01-01

    Non-coding RNA molecules are able to regulate gene expression and play an essential role in cells. On the other hand, bistability is an important behaviour of genetic networks. Here, we propose and study an ODE model in order to show how non-coding RNA can produce bistability in a simple way. The model comprises a single gene with positive feedback that is repressed by non-coding RNA molecules. We show how the values of all the reaction rates involved in the model are able to control the transitions between the high and low states. This new model can be interesting to clarify the role of non-coding RNA molecules in genetic networks. As well, these results can be interesting in synthetic biology for developing new genetic memories and biomolecular devices based on non-coding RNAs.

  10. Eversion of bistable shells under magnetic actuation: a model of nonlinear shapes

    NASA Astrophysics Data System (ADS)

    Seffen, Keith A.; Vidoli, Stefano

    2016-06-01

    We model in closed form a proven bistable shell made from a magnetic rubber composite material. In particular, we incorporate a non-axisymmetrical displacement field, and we capture the nonlinear coupling between the actuated shape and the magnetic flux distribution around the shell. We are able to verify the bistable nature of the shell and we explore its eversion during magnetic actuation. We show that axisymmetrical eversion is natural for a perfect shell but that non-axisymmetrical eversion rapidly emerges under very small initial imperfections, as observed in experiments and in a computational analysis. We confirm the non-uniform shapes of shell and we study the stability of eversion by considering how the landscape of total potential and magnetic energies of the system changes during actuation.

  11. Pattern formation in the thiourea-iodate-sulfite system: Spatial bistability, waves, and stationary patterns

    NASA Astrophysics Data System (ADS)

    Horváth, Judit; Szalai, István; De Kepper, Patrick

    2010-06-01

    We present a detailed study of the reaction-diffusion patterns observed in the thiourea-iodate-sulfite (TuIS) reaction, operated in open one-side-fed reactors. Besides spatial bistability and spatio-temporal oscillatory dynamics, this proton autoactivated reaction shows stationary patterns, as a result of two back-to-back Turing bifurcations, in the presence of a low-mobility proton binding agent (sodium polyacrylate). This is the third aqueous solution system to produce stationary patterns and the second to do this through a Turing bifurcation. The stationary pattern forming capacities of the reaction are explored through a systematic design method, which is applicable to other bistable and oscillatory reactions. The spatio-temporal dynamics of this reaction is compared with that of the previous ferrocyanide-iodate-sulfite mixed Landolt system.

  12. Quantitative approaches to the study of bistability in the lac operon of Escherichia coli.

    PubMed

    Santillán, Moisés; Mackey, Michael C

    2008-08-01

    In this paper, the history and importance of the lac operon in the development of molecular and systems biology are briefly reviewed. We start by presenting a description of the regulatory mechanisms in this operon, taking into account the most recent discoveries. Then we offer a survey of the history of the lac operon, including the discovery of its main elements and the subsequent influence on the development of molecular and systems biology. Next the bistable behaviour of the operon is discussed, both with respect to its discovery and its molecular origin. A review of the literature in which this bistable phenomenon has been studied from a mathematical modelling viewpoint is then given. We conclude with some brief remarks. PMID:18426771

  13. Bistable liquid crystal devices with nanoparticle-coated polyimide alignment films.

    PubMed

    Lee, Chuan-En; Jeng, Shie-Chang

    2013-04-01

    Bistable hybrid-aligned nematic (HAN) liquid crystal devices (LCDs) with silica nanoparticle-coated polyimide alignment films were investigated. It was observed that the existence of the internal electric field produced from the triboelectrically charged silica nanoparticles layer and impurity ions in the LC reduced the total free energy of the HAN-LCD and stabilized the cell in the homeotropic state. The stable homeotropic state can be switched back to the HAN state by changing the ion distribution through a voltage pulse with proper polarity. The capability of controlling bistability through modification of ion density in the LC layer may have some applications, such as displaying a one-time password requiring a specific stable time. PMID:23546227

  14. Quantitative approaches to the study of bistability in the lac operon of Escherichia coli.

    PubMed

    Santillán, Moisés; Mackey, Michael C

    2008-08-01

    In this paper, the history and importance of the lac operon in the development of molecular and systems biology are briefly reviewed. We start by presenting a description of the regulatory mechanisms in this operon, taking into account the most recent discoveries. Then we offer a survey of the history of the lac operon, including the discovery of its main elements and the subsequent influence on the development of molecular and systems biology. Next the bistable behaviour of the operon is discussed, both with respect to its discovery and its molecular origin. A review of the literature in which this bistable phenomenon has been studied from a mathematical modelling viewpoint is then given. We conclude with some brief remarks.

  15. Evaluation of the current biased integrated optical processors based on bistable dode elements

    NASA Astrophysics Data System (ADS)

    Tang, C. L.; Swanson, P. D.; Parker, M. A.; Libby, S. I.

    1994-07-01

    Three optical switching elements have been designed, fabricated and tested for use in an integrated, optical signal processor. The first, and optical NOR logic gate, uses gain quenching as a means of allowing one (or more) light beam (s) to control the output light. This technique, along with the use of a two-pad bistable output laser, is used in the demonstration of the feasibility of the second device, an all optical RS flip-flop. The third device consists of a broad area orthogonal mode switch laser, whose corollary outputs correspond to the sign of the voltage difference between its two high impedance electrical inputs. This device also has possible memory applications if bistable mode switching within the broad area laser can be achieved.

  16. Emission spectra and intrinsic optical bistability in a two-level medium

    NASA Astrophysics Data System (ADS)

    Gladush, M. G.; Kuznetsov, D. V.; Roerich, Vl. K.

    2011-10-01

    Scattering of resonant radiation in a dense two-level medium is studied theoretically accounting for local field effects and renormalisation of the resonance frequency. Intrinsic optical bistability is viewed as switching between different spectral patterns of fluorescent light controlled by the incident field strength. Response spectra are calculated analytically for the entire hysteresis loop of atomic excitation. The equations to describe the non-linear interaction of an atomic ensemble with light are derived from the Bogolubov-Born-Green-Kirkwood-Yvon hierarchy for reduced single particle density matrices of atoms and quantised field modes and their correlation operators. The spectral power of scattered light with separated coherent and incoherent constituents is obtained straightforwardly within the hierarchy. The formula obtained for emission spectra can be used to distinguish between possible mechanisms suggested to produce intrinsic bistability in experiments.

  17. Heating-up Synthesis of MoS2 Nanosheets and Their Electrical Bistability Performance

    NASA Astrophysics Data System (ADS)

    Li, Xu; Tang, Aiwei; Li, Jiantao; Guan, Li; Dong, Guoyi; Teng, Feng

    2016-03-01

    Molybdenum disulfide (MoS2) nanosheets were synthesized by using a simple heating-up approach, in which 1-dodecanethiol (DDT) was used not only as a sulfur source but also as the surface ligand. The sheet-like morphology was confirmed by the transmission electron microscopy (TEM) and atomic force microscopy (AFM) results, and the X-ray diffraction (XRD) patterns and Raman spectrum were employed to characterize the structure of the as-synthesized MoS2 nanosheets. The as-obtained MoS2 nanosheets blending with a polymer could be used to fabricate an electrically bistable device through a simple spin-coating method, and the device exhibited an obvious electrical bistability in the I-V curve. The charge transport of the device was discussed based on the organic electronic models.

  18. All-optical 2-bit header recognition and packet switching using polarization bistable VCSELs.

    PubMed

    Hayashi, Daisuke; Nakao, Kazuya; Katayama, Takeo; Kawaguchi, Hitoshi

    2015-04-01

    We propose and evaluate an all-optical 2-bit header recognition and packet switching method using two 1.55-µm polarization bistable vertical-cavity surface-emitting lasers (VCSELs) and three optical switches. Polarization bistable VCSELs acted as flip-flop devices by using AND-gate operations of the header and set pulses, together with the reset pulses. Optical packets including 40-Gb/s non-return-to-zero pseudo-random bit-sequence payloads were successfully sent to one of four ports according to the state of two bits in the headers with a 4-bit 500-Mb/s return-to-zero format. The input pulse powers were 17.2 to 31.8 dB lower than the VCSEL output power. We also examined an extension of this method to multi-bit header recognition and packet switching.

  19. PHYSICAL BASIS OF QUANTUM ELECTRONICS: Symmetry breaking in optical dynamics of two bistable thin films

    NASA Astrophysics Data System (ADS)

    Babushkin, I. V.; Logvin, Yu A.; Loiko, N. A.

    1998-02-01

    A theoretical investigation is reported of the interaction of light with a system of two films which contain two-level centres and whose thickness is less than the incident radiation wavelength. It is shown that when light of the same intensity is incident from both sides of the films, symmetry-breaking bifurcation is possible, i.e. the transmitted fields are different for the opposite directions. The relationship between symmetry-breaking bifurcation and optical bistability is determined. If the distance between the films represents an odd number of the optical half-wavelengths symmetry breaking occurs at a lower value of the parameter representing the interaction nonlinearity than that corresponding to the onset of bistability. The opposite is true when an even number of half-wavelengths can be fitted between the films. The supression of symmetry-breaking bifurcation is illustrated for various intensities of the incident optical field.

  20. Thermodynamic Limit of a Nonequilibrium Steady State: Maxwell-Type Construction for a Bistable Biochemical System

    NASA Astrophysics Data System (ADS)

    Ge, Hao; Qian, Hong

    2009-10-01

    We show that the thermodynamic limit of a bistable phosphorylation-dephosphorylation cycle has a selection rule for the “more stable” macroscopic steady state. The analysis is akin to the Maxwell construction. Based on the chemical master equation approach, it is shown that, except at a critical point, bistability disappears in the stochastic model when fluctuation is sufficiently low but unneglectable. Onsager’s Gaussian fluctuation theory applies to the unique macroscopic steady state. With an initial state in the basin of attraction of the “less stable” steady state, the deterministic dynamics obtained by the law of mass action is a metastable phenomenon. Stability and robustness in cell biology are emergent stochastic concepts.

  1. Effects of Moderate Noise on a Limit Cycle Oscillator: Counterrotation and Bistability

    NASA Astrophysics Data System (ADS)

    Newby, Jay M.; Schwemmer, Michael A.

    2014-03-01

    The effects of noise on the dynamics of nonlinear systems is known to lead to many counterintuitive behaviors. Using simple planar limit cycle oscillators, we show that the addition of moderate noise leads to qualitatively different dynamics. In particular, the system can appear bistable, rotate in the opposite direction of the deterministic limit cycle, or cease oscillating altogether. Utilizing standard techniques from stochastic calculus and recently developed stochastic phase reduction methods, we elucidate the mechanisms underlying the different dynamics and verify our analysis with the use of numerical simulations. Last, we show that similar bistable behavior is found when moderate noise is applied to the FitzHugh-Nagumo model, which is more commonly used in biological applications.

  2. Rigid Cluster Decomposition Reveals Criticality in Frictional Jamming

    NASA Astrophysics Data System (ADS)

    Henkes, Silke; Quint, David A.; Fily, Yaouen; Schwarz, J. M.

    2016-01-01

    We study the nature of the frictional jamming transition within the framework of rigidity percolation theory. Slowly sheared frictional packings are decomposed into rigid clusters and floppy regions with a generalization of the pebble game including frictional contacts. Our method suggests a second-order transition controlled by the emergence of a system-spanning rigid cluster accompanied by a critical cluster size distribution. Rigid clusters also correlate with common measures of rigidity. We contrast this result with frictionless jamming, where the rigid cluster size distribution is noncritical.

  3. Rigid Cluster Decomposition Reveals Criticality in Frictional Jamming.

    PubMed

    Henkes, Silke; Quint, David A; Fily, Yaouen; Schwarz, J M

    2016-01-15

    We study the nature of the frictional jamming transition within the framework of rigidity percolation theory. Slowly sheared frictional packings are decomposed into rigid clusters and floppy regions with a generalization of the pebble game including frictional contacts. Our method suggests a second-order transition controlled by the emergence of a system-spanning rigid cluster accompanied by a critical cluster size distribution. Rigid clusters also correlate with common measures of rigidity. We contrast this result with frictionless jamming, where the rigid cluster size distribution is noncritical. PMID:26824572

  4. Quasiclassical trajectory studies of rigid rotor--rigid surface scattering. II. Corrugated surface

    SciTech Connect

    Park, S.C.; Bowman, J.M.

    1984-03-01

    The quasiclassical trajectory method, previously applied to rigid rotor--rigid flat surface scattering (J. M. Bowman and S. C. Park, J. Chem. Phys. 77, 5441 (1982)) is applied to a rigid rotor--rigid corrugated surface, i.e., a N/sub 2/--LiF(001), system. The mechanisms for rotational excitation at low and high collision energies are studied as well as their dependence on initial beam orientation and corrugation strength. A significant correlation between long-lived trajectories and high rotational excitation is found for low energy collisions and rotational rainbows are clearly observed in the high energy regime, although these features are broadened relative to the flat surface reported previously.

  5. Method of bistable optical information storage using antiferroelectric phase PLZT ceramics

    DOEpatents

    Land, Cecil E.

    1990-01-01

    A method for bistable storage of binary optical information includes an antiferroelectric (AFE) lead lanthanum zirconate titanate (PLZT) layer having a stable antiferroelectric first phase and a ferroelectric (FE) second phase obtained by applying a switching electric field across the surface of the device. Optical information is stored by illuminating selected portions of the layer to photoactivate an FE to AFE transition in those portions. Erasure of the stored information is obtained by reapplying the switching field.

  6. Method of bistable optical information storage using antiferroelectric phase PLZT ceramics

    DOEpatents

    Land, C.E.

    1990-07-31

    A method for bistable storage of binary optical information includes an antiferroelectric (AFE) lead lanthanum zirconate titanate (PLZT) layer having a stable antiferroelectric first phase and a ferroelectric (FE) second phase obtained by applying a switching electric field across the surface of the device. Optical information is stored by illuminating selected portions of the layer to photoactivate an FE to AFE transition in those portions. Erasure of the stored information is obtained by reapplying the switching field. 8 figs.

  7. Demonstration of brain noise on human EEG signals in perception of bistable images

    NASA Astrophysics Data System (ADS)

    Grubov, Vadim V.; Runnova, Anastasiya E.; Kurovskaya, Maria K.; Pavlov, Alexey N.; Koronovskii, Alexey A.; Hramov, Alexander E.

    2016-03-01

    In this report we studied human brain activity in the case of bistable visual perception. We proposed a new approach for quantitative characterization of this activity based on analysis of EEG oscillatory patterns and evoked potentials. Accordingly to theoretical background, obtained experimental EEG data and results of its analysis we studied a characteristics of brain activity during decision-making. Also we have shown that decisionmaking process has the special patterns on the EEG data.

  8. Solution-verified reliability analysis and design of bistable MEMS using error estimation and adaptivity.

    SciTech Connect

    Eldred, Michael Scott; Subia, Samuel Ramirez; Neckels, David; Hopkins, Matthew Morgan; Notz, Patrick K.; Adams, Brian M.; Carnes, Brian; Wittwer, Jonathan W.; Bichon, Barron J.; Copps, Kevin D.

    2006-10-01

    This report documents the results for an FY06 ASC Algorithms Level 2 milestone combining error estimation and adaptivity, uncertainty quantification, and probabilistic design capabilities applied to the analysis and design of bistable MEMS. Through the use of error estimation and adaptive mesh refinement, solution verification can be performed in an automated and parameter-adaptive manner. The resulting uncertainty analysis and probabilistic design studies are shown to be more accurate, efficient, reliable, and convenient.

  9. Reciprocal enzyme regulation as a source of bistability in covalent modification cycles.

    PubMed

    Straube, Ronny; Conradi, Carsten

    2013-08-01

    Covalent modification cycles (CMCs) are the building blocks of many regulatory networks in biological systems. Under proper kinetic conditions such mono-cyclic enzyme systems can show a higher sensitivity to effectors than enzymes subject to direct allosteric regulation. Using methods from reaction network theory it has been argued that CMCs can potentially exhibit multiple steady states if the converter enzymes are regulated in a reciprocal manner, but the underlying mechanism as well as the kinetic requirements for the emergence of such a behavior remained unclear. Here, we reinvestigate CMCs with reciprocal regulation of the converter enzymes for two common regulatory mechanisms: allosteric regulation and covalent modification. To analyze the steady state behavior of the corresponding mass-action equations, we derive reduced models by means of a quasi-steady state approximation (QSSA). We also derive reduced models using the total QSSA which often better reproduces the transient dynamics of enzyme-catalyzed reaction systems. Through a steady state analysis of the reduced models we show that the occurrence of bistability can be associated with the presence of a double negative feedback loop. We also derive constraints for the model parameters which might help to evaluate the potential significance of the mechanisms described here for the generation of bistability in natural systems. In particular, our results support the view of a possible bistable response in the metabolic PFK1/F1,6BPase cycle as observed experimentally in rat liver extracts, and it suggests an alternative view on the origin of bistability in the Cdk1-Wee1-Cdc25 system.

  10. Dynamical suppression of telegraph and 1/f noise due to quantum bistable fluctuators

    SciTech Connect

    Falci, G.; D'Arrigo, A.; Mastellone, A.; Paladino, E.

    2004-10-01

    We study dynamical decoupling of a qubit from non-Gaussian quantum noise due to discrete sources, as bistable fluctuators and 1/f noise. We obtain analytic and numerical results for generic operating points. For very large pulse frequency, where dynamic decoupling compensates decoherence, we found universal behavior. At intermediate frequencies noise can be compensated or enhanced, depending on the nature of the fluctuators and on the operating point. Our technique can be applied to a larger class of non-Gaussian environments.

  11. Bistable expression of virulence genes in salmonella leads to the formation of an antibiotic-tolerant subpopulation.

    PubMed

    Arnoldini, Markus; Vizcarra, Ima Avalos; Peña-Miller, Rafael; Stocker, Nicolas; Diard, Médéric; Vogel, Viola; Beardmore, Robert E; Hardt, Wolf-Dietrich; Ackermann, Martin

    2014-08-01

    Phenotypic heterogeneity can confer clonal groups of organisms with new functionality. A paradigmatic example is the bistable expression of virulence genes in Salmonella typhimurium, which leads to phenotypically virulent and phenotypically avirulent subpopulations. The two subpopulations have been shown to divide labor during S. typhimurium infections. Here, we show that heterogeneous virulence gene expression in this organism also promotes survival against exposure to antibiotics through a bet-hedging mechanism. Using microfluidic devices in combination with fluorescence time-lapse microscopy and quantitative image analysis, we analyzed the expression of virulence genes at the single cell level and related it to survival when exposed to antibiotics. We found that, across different types of antibiotics and under concentrations that are clinically relevant, the subpopulation of bacterial cells that express virulence genes shows increased survival after exposure to antibiotics. Intriguingly, there is an interplay between the two consequences of phenotypic heterogeneity. The bet-hedging effect that arises through heterogeneity in virulence gene expression can protect clonal populations against avirulent mutants that exploit and subvert the division of labor within these populations. We conclude that bet-hedging and the division of labor can arise through variation in a single trait and interact with each other. This reveals a new degree of functional complexity of phenotypic heterogeneity. In addition, our results suggest a general principle of how pathogens can evade antibiotics: Expression of virulence factors often entails metabolic costs and the resulting growth retardation could generally increase tolerance against antibiotics and thus compromise treatment.

  12. Modeling of optically controlled reflective bistability in a vertical cavity semiconductor saturable absorber

    NASA Astrophysics Data System (ADS)

    Mishra, L.

    2015-05-01

    Bistability switching between two optical signals has been studied theoretically utilizing the concept of cross absorption modulation in a vertical cavity semiconductor saturable absorber (VCSSA). The probe beam is fixed at a wavelength other than the low power cavity resonance wavelength, which exhibits bistable characteristic by controlling the power of a pump beam (λpump≠λprobe). The cavity nonlinear effects that arises simultaneously from the excitonic absorption bleaching, and the carrier induced nonlinear index change has been considered in the model. The high power absorption in the active region introduces thermal effects within the nonlinear cavity due to which the effective cavity length changes. This leads to a red-shift of the cavity resonance wavelength, which results a change in phase of the optical fields within the cavity. In the simulation, the phase-change due to this resonance shifting is considered to be constant over time, and it assumes the value corresponding to the maximum input power. Further, an initial phase detuning of the probe beam has been considered to investigate its effect on switching. It is observed from the simulated results that, the output of the probe beam exhibits either clockwise or counter-clockwise bistability, depending on its initial phase detuning.

  13. Size-dependent bistability of an electrostatically actuated arch NEMS based on strain gradient theory

    NASA Astrophysics Data System (ADS)

    Tajaddodianfar, Farid; Nejat Pishkenari, Hossein; Hairi Yazdi, Mohammad Reza; Maani Miandoab, Ehsan

    2015-06-01

    This paper deals with the investigation of the size-dependent nature of nonlinear dynamics, in a doubly clamped shallow nano-arch actuated by spatially distributed electrostatic force. We employ strain gradient theory together with the Euler-Bernoulli and shallow arch assumptions in order to derive the nonlinear partial differential equation governing the transverse motion of the arch with mid-plane stretching effects. Using the Galerkin projection method, we derive the lumped single degree of freedom model which is then used for the study of the size effects on the nonlinear snap-through and pull-in instabilities of the arch nano-electro-mechanical-system (NEMS). Moreover, using strain gradient theory, the size-dependent bistability and fundamental frequencies of the nano-arch are scrutinized, revealing that, despite what is predicted by the classical theory, the bistability region in the parameter space of the nano-structure shrinks as the structure scales down. Also, we show that the minimum initial elevation, required for bistability, increases as the nano-arch scales down.

  14. On square-wave-driven stochastic resonance for energy harvesting in a bistable system

    NASA Astrophysics Data System (ADS)

    Su, Dongxu; Zheng, Rencheng; Nakano, Kimihiko; Cartmell, Matthew P.

    2014-11-01

    Stochastic resonance is a physical phenomenon through which the throughput of energy within an oscillator excited by a stochastic source can be boosted by adding a small modulating excitation. This study investigates the feasibility of implementing square-wave-driven stochastic resonance to enhance energy harvesting. The motivating hypothesis was that such stochastic resonance can be efficiently realized in a bistable mechanism. However, the condition for the occurrence of stochastic resonance is conventionally defined by the Kramers rate. This definition is inadequate because of the necessity and difficulty in estimating white noise density. A bistable mechanism has been designed using an explicit analytical model which implies a new approach for achieving stochastic resonance in the paper. Experimental tests confirm that the addition of a small-scale force to the bistable system excited by a random signal apparently leads to a corresponding amplification of the response that we now term square-wave-driven stochastic resonance. The study therefore indicates that this approach may be a promising way to improve the performance of an energy harvester under certain forms of random excitation.

  15. Geometry of Basins of Attraction and Heteroclinic Connections in Coupled Bistable Systems

    NASA Astrophysics Data System (ADS)

    Lyons, Daniel; Mahaffy, Joseph M.; Wang, Sara; Palacios, Antonio; in, Visarath

    The fundamental principle of bistability is widely used across various disciplines, including biology, chemistry, mechanics, physics, electronics and materials science. As the need for more powerful, efficient and sensitive complex-engineered systems grow, networks of coupled bistable systems have gained significant attention in recent years. Modeling and analysis of such higher-dimensional systems is usually focused on finding conditions for the existence and stability of typical invariant sets, i.e. steady states, periodic solutions and chaotic sets. High-dimensionality leads to complex patterns of collective behavior. Which type of behavior is exhibited by a network depends greatly on the initial conditions. Thus, it is also important to study the geometric structure and evolution of the basins of attraction of such patterns. In this manuscript, a complete study of the basins of attraction of a ring of bistable systems, coupled unidirectionally, is presented. 3D visualizations are included to aid the discussion of the changes in the basins of attraction as the coupling parameter varies. The results are broad enough that they can be applied to a wide range of systems with similar coupling topologies.

  16. Revisiting bistability in the lysis/lysogeny circuit of bacteriophage lambda.

    PubMed

    Bednarz, Michael; Halliday, Jennifer A; Herman, Christophe; Golding, Ido

    2014-01-01

    The lysis/lysogeny switch of bacteriophage lambda serves as a paradigm for binary cell fate decision, long-term maintenance of cellular state and stimulus-triggered switching between states. In the literature, the system is often referred to as "bistable." However, it remains unclear whether this term provides an accurate description or is instead a misnomer. Here we address this question directly. We first quantify transcriptional regulation governing lysogenic maintenance using a single-cell fluorescence reporter. We then use the single-cell data to derive a stochastic theoretical model for the underlying regulatory network. We use the model to predict the steady states of the system and then validate these predictions experimentally. Specifically, a regime of bistability, and the resulting hysteretic behavior, are observed. Beyond the steady states, the theoretical model successfully predicts the kinetics of switching from lysogeny to lysis. Our results show how the physics-inspired concept of bistability can be reliably used to describe cellular phenotype, and how an experimentally-calibrated theoretical model can have accurate predictive power for cell-state switching. PMID:24963924

  17. Stochasticity, Bistability and the Wisdom of Crowds: A Model for Associative Learning in Genetic Regulatory Networks

    PubMed Central

    Sorek, Matan; Balaban, Nathalie Q.; Loewenstein, Yonatan

    2013-01-01

    It is generally believed that associative memory in the brain depends on multistable synaptic dynamics, which enable the synapses to maintain their value for extended periods of time. However, multistable dynamics are not restricted to synapses. In particular, the dynamics of some genetic regulatory networks are multistable, raising the possibility that even single cells, in the absence of a nervous system, are capable of learning associations. Here we study a standard genetic regulatory network model with bistable elements and stochastic dynamics. We demonstrate that such a genetic regulatory network model is capable of learning multiple, general, overlapping associations. The capacity of the network, defined as the number of associations that can be simultaneously stored and retrieved, is proportional to the square root of the number of bistable elements in the genetic regulatory network. Moreover, we compute the capacity of a clonal population of cells, such as in a colony of bacteria or a tissue, to store associations. We show that even if the cells do not interact, the capacity of the population to store associations substantially exceeds that of a single cell and is proportional to the number of bistable elements. Thus, we show that even single cells are endowed with the computational power to learn associations, a power that is substantially enhanced when these cells form a population. PMID:23990765

  18. Bistability of a coupled Aurora B kinase-phosphatase system in cell division

    PubMed Central

    Zaytsev, Anatoly V; Segura-Peña, Dario; Godzi, Maxim; Calderon, Abram; Ballister, Edward R; Stamatov, Rumen; Mayo, Alyssa M; Peterson, Laura; Black, Ben E; Ataullakhanov, Fazly I; Lampson, Michael A; Grishchuk, Ekaterina L

    2016-01-01

    Aurora B kinase, a key regulator of cell division, localizes to specific cellular locations, but the regulatory mechanisms responsible for phosphorylation of substrates located remotely from kinase enrichment sites are unclear. Here, we provide evidence that this activity at a distance depends on both sites of high kinase concentration and the bistability of a coupled kinase-phosphatase system. We reconstitute this bistable behavior and hysteresis using purified components to reveal co-existence of distinct high and low Aurora B activity states, sustained by a two-component kinase autoactivation mechanism. Furthermore, we demonstrate these non-linear regimes in live cells using a FRET-based phosphorylation sensor, and provide a mechanistic theoretical model for spatial regulation of Aurora B phosphorylation. We propose that bistability of an Aurora B-phosphatase system underlies formation of spatial phosphorylation patterns, which are generated and spread from sites of kinase autoactivation, thereby regulating cell division. DOI: http://dx.doi.org/10.7554/eLife.10644.001 PMID:26765564

  19. Bistable light shutter using dye-doped liquid crystals for a see-through display

    NASA Astrophysics Data System (ADS)

    Huh, Jae-Won; Heo, Joon; Yu, Byeong-Huh; Yoon, Tae-Hoon

    2016-03-01

    See-through displays have got high attention as one of the next generation display devices. Especially, see-through displays that use organic light-emitting diodes (OLEDs) and liquid crystal displays (LCDs) have been actively studied. However, a see-through display using OLEDs cannot provide black color because of their see-through area. Although a see-through display using LCDs can provide black color with crossed polarizers, it cannot block the background. This inevitable problem can be solved by placing a light shutter at the back of a see-through display. To maintain the transparent or opaque state, an electric field must be applied to a light shutter. To achieve low power consumption, a bistable light shutter using polymer-stabilized cholesteric liquid crystals (CLC) has been proposed. It is switchable between the translucent and transparent states only. Therefore, it cannot provide black color. Moreover, it cannot block the background perfectly because of poor performance in the translucent state. In this work we will introduce a bistable light shutter using dye-doped CLCs. To improve the electro-optic characteristics in the opaque state, we employed a crossed electrode structure instead of a parallel one. We will demonstrate that the light shutter can exhibit stable bistable operation between the transparent homeotropic and opaque focal-conic states thanks to polymer stabilization.

  20. On the cross-well dynamics of a bi-stable composite plate

    NASA Astrophysics Data System (ADS)

    Arrieta, Andres F.; Neild, Simon A.; Wagg, David J.

    2011-07-01

    Multi-stable composites are a novel type of composites capable of adopting multiple statically stable configurations. Due to the multi-stability property this type of composite material has been considered for several applications, particularly for morphing structures. The change of shape between stable states is achieved by a nonlinear mechanism known as snap-through. Most of the research done on these composites has focused on predicting the configuration after manufacture, its static characteristics and static actuation strategies to induce snap-through. However, these structures will operate subject to dynamic loads. Yet, very little work has been carried out to examine the dynamic behaviour of bi-stable composites. This paper focuses on the study of the cross-well dynamics of a bi-stable composite plate. A simple model previously derived for the dynamics confined to a single stable state is extended to include cross-well dynamics. The rich dynamics are experimentally investigated, focusing on cross-well oscillations and the key dynamic features of snap-through. Numerical simulations are obtained and compared to the experimental results showing good agreement. In particular, experimentally observed characteristics suggesting chaotic oscillations for cross-well dynamics are captured well by the proposed model. The results herein could be used for implementing control strategies for both configuration morphing and undesired snap-through suppression of bi-stable composites.

  1. Redox reaction based negative differential resistance and bistability in nanoparticulate ZnO films

    NASA Astrophysics Data System (ADS)

    Ghosh, Manoranjan; Gadkari, S. C.; Gupta, S. K.

    2012-07-01

    Negative differential resistance (NDR) and bistability in the current-voltage (I-V) characteristics have been demonstrated for a simple device fabricated from ZnO nanoparticles (NPs). The Au/ZnO/Au device (ZnO nanoparticles size: 5-15 nm) attains ON and OFF states during forward and reverse voltage scans, respectively, akin to a cyclic voltammogram. The origin of the observed NDR and bistability is traced to the protonic conduction resulting from the dissociation of adsorbed moisture on the surface of ZnO nanoparticles. Water layers adsorbed on the ZnO surface dissociate into hydroxyl ions at the oxygen vacancy (Vo) site and transfer a proton to the nearby water molecule. Signature of NDR is created when the rate of redox reactions at the electrode is faster than the generation and transport of reactants. Oxygen vacancies considered as active sites for water dissociation reside predominantly at the surface due to their low formation energy. So, the degree of bistability and NDR are found to decrease with increasing particle size having relatively lower surface to volume ratio and eventually disappears for fairly large nanorods (dia. ˜100-200 nm and length 1-2 μm).

  2. On square-wave-driven stochastic resonance for energy harvesting in a bistable system

    SciTech Connect

    Su, Dongxu; Zheng, Rencheng; Nakano, Kimihiko; Cartmell, Matthew P

    2014-11-15

    Stochastic resonance is a physical phenomenon through which the throughput of energy within an oscillator excited by a stochastic source can be boosted by adding a small modulating excitation. This study investigates the feasibility of implementing square-wave-driven stochastic resonance to enhance energy harvesting. The motivating hypothesis was that such stochastic resonance can be efficiently realized in a bistable mechanism. However, the condition for the occurrence of stochastic resonance is conventionally defined by the Kramers rate. This definition is inadequate because of the necessity and difficulty in estimating white noise density. A bistable mechanism has been designed using an explicit analytical model which implies a new approach for achieving stochastic resonance in the paper. Experimental tests confirm that the addition of a small-scale force to the bistable system excited by a random signal apparently leads to a corresponding amplification of the response that we now term square-wave-driven stochastic resonance. The study therefore indicates that this approach may be a promising way to improve the performance of an energy harvester under certain forms of random excitation.

  3. Origin of rigidity in athermal materials

    NASA Astrophysics Data System (ADS)

    Sarkar, Sumantra

    Solids are distinguished from fluids by their ability to resist shear. In traditional solids, the resistance to shear is associated with the emergence of broken translational symmetry as exhibited by a non-uniform density pattern, which results from either minimizing the energy cost or maximizing the entropy or both. In this thesis, we focus on a special class of materials where this paradigm is challenged. We argue that the observation of rigidity in dry granular materials, a representative system, is a collective process controlled solely by few constraints, e.g., the boundary stresses, the constraint of force and torque balance, and the positivity of contact forces. We have shown that these constraints lead to a broken translational symmetry in a dual space of heights (loop forces) which leads to the observed rigidity (jamming) in such a system. We investigate the structure and behavior of the dual space through a geometrical construction as the system evolves towards the rigidity transition, commonly known as jamming. In that context, we explore the role of friction in jamming and establish the equivalence of real space and stress space description. We conclude that the role of real space geometry is negligible, and a stress only description is sufficient to understand the phenomenology of jamming. In the second half of the thesis, we develop a phenomenological model of the shear induced rigidity in athermal materials. Recent studies of athermal systems such as dry grains and dense, non-Brownian suspensions have shown that shear can lead to solidification through the process of shear jamming in grains and discontinuous shear thickening in suspensions. The similarities observed between these two distinct phenomena suggest that the physical processes leading to shear-induced rigidity in athermal materials are universal. We present a non-equilibrium statistical mechanics model, which exhibits the phenomenology of these shear-driven transitions: shear jamming and

  4. Does a rigid body limit maneuverability?

    PubMed

    Walker, J A

    2000-11-01

    Whether a rigid body limits maneuverability depends on how maneuverability is defined. By the current definition, the minimum radius of the turn, a rigid-bodied, spotted boxfish Ostracion meleagris approaches maximum maneuverability, i.e. it can spin around with minimum turning radii near zero. The radius of the minimum space required to turn is an alternative measure of maneuverability. By this definition, O. meleagris is not very maneuverable. The observed space required by O. meleagris to turn is slightly greater than its theoretical minimum but much greater than that of highly flexible fish. Agility, the rate of turning, is related to maneuverability. The median- and pectoral-fin-powered turns of O. meleagris are slow relative to the body- and caudal-fin-powered turns of more flexible fish.

  5. Coupling between feedback loops in autoregulatory networks affects bistability range, open-loop gain and switching times

    NASA Astrophysics Data System (ADS)

    Tiwari, Abhinav; Igoshin, Oleg A.

    2012-10-01

    Biochemical regulatory networks governing diverse cellular processes such as stress-response, differentiation and cell cycle often contain coupled feedback loops. We aim at understanding how features of feedback architecture, such as the number of loops, the sign of the loops and the type of their coupling, affect network dynamical performance. Specifically, we investigate how bistability range, maximum open-loop gain and switching times of a network with transcriptional positive feedback are affected by additive or multiplicative coupling with another positive- or negative-feedback loop. We show that a network's bistability range is positively correlated with its maximum open-loop gain and that both quantities depend on the sign of the feedback loops and the type of feedback coupling. Moreover, we find that the addition of positive feedback could decrease the bistability range if we control the basal level in the signal-response curves of the two systems. Furthermore, the addition of negative feedback has the capacity to increase the bistability range if its dissociation constant is much lower than that of the positive feedback. We also find that the addition of a positive feedback to a bistable network increases the robustness of its bistability range, whereas the addition of a negative feedback decreases it. Finally, we show that the switching time for a transition from a high to a low steady state increases with the effective fold change in gene regulation. In summary, we show that the effect of coupled feedback loops on the bistability range and switching times depends on the underlying mechanistic details.

  6. TLP rigid riser; A case study

    SciTech Connect

    Rooney, P.P.; Engebretsen, K.B. ); Pettersen, D.J. )

    1992-03-01

    This paper summarizes tension-leg platform (TLP) rigid riser design considerations and presents results of TLP riser analysis for a production/injection riser in the North Sea. Analysis methods, design criteria, and design optimization are addressed. The riser is designed for 300-m water depth in compliance with Norwegian regulations. Emphasis is placed on application of the regulations and quantitative comparison of alternative methods for analysis of fatigue and extremes.

  7. Amiodarone keratopathy and rigid contact lens wear.

    PubMed

    Astin, C L

    2001-01-01

    Two cases are presented of patients wearing rigid gas permeable contact lenses who exhibited the typical fan-shaped patterns of corneal pigment deposition related to long-term medication containing amiodarone. The vortex corneal epitheliopathy and contact lens tolerance were monitored over several years. In both cases, the lens material was replaced with one incorporating an ultra-violet light inhibitor in view of the possibility of medically induced photosensitivity.

  8. Rigid plastic collars for marking geese

    USGS Publications Warehouse

    Ballou, R.M.; Martin, F.W.

    1964-01-01

    Rigid plastic collars of one to three colors proved useful for recognition of individual Canada geese (Branta canadensis). The collars did not seem to affect the behavior of the geese, and there was little mortality caused by their use. In good light, bright colors are visible through a 20-power spotting scope for more than 1 mile. Retention of collars was about 90 percent for 1 year and more than 80 percent for 2 years.

  9. Rapid determination of RMSDs corresponding to macromolecular rigid body motions.

    PubMed

    Popov, Petr; Grudinin, Sergei

    2014-05-01

    Finding the root mean sum of squared deviations (RMSDs) between two coordinate vectors that correspond to the rigid body motion of a macromolecule is an important problem in structural bioinformatics, computational chemistry, and molecular modeling. Standard algorithms compute the RMSD with time proportional to the number of atoms in the molecule. Here, we present RigidRMSD, a new algorithm that determines a set of RMSDs corresponding to a set of rigid body motions of a macromolecule in constant time with respect to the number of atoms in the molecule. Our algorithm is particularly useful for rigid body modeling applications, such as rigid body docking, and also for high-throughput analysis of rigid body modeling and simulation results. We also introduce a constant-time rotation RMSD as a similarity measure for rigid molecules. A C++ implementation of our algorithm is available at http://nano-d.inrialpes.fr/software/RigidRMSD. PMID:24615729

  10. Geometric simulation of structures containing rigid units

    NASA Astrophysics Data System (ADS)

    Wells, Stephen

    2005-03-01

    Much insight into the behaviour of the framework silicates can be obtained from the Rigid Unit model. I review results from geometric analyses [1] of framework structures, quantifying the significance of rigid unit motion in thermal disorder and in defect accomodation, and from a method of simulation [2,3] based on a whole-body `geometric potential' rather than on interatomic potentials. I show the application of the geometric potential to the symmetry-constrained generation of hypothetical zeolite frameworks [4], and to the rapid generation of protein conformations using insights from rigid cluster decomposition [5]. 1. Wells, Dove and Tucker, Journal of Applied Crystallography, 37:536--544 (2004). 2. G.D. Gatta and S.A. Wells, Phys. Chem. Min. 31:1--10 (2004). 3. A. Sartbaeva, S. A. Wells, S. A. T. Redfern, J. Phys.: Condens. Matter 16, 8173 (2004) 4. M. M. J. Treacy, I. Rivin, E. Balkovsky, K. H. Randall and M. D. Foster, Micropor. Mesopor. Mater. 74, 121-132 (2004). 5. M.F. Thorpe, Ming Lei, A.J. Rader, Donald J. Jacobs, and Leslie A. Kuhn, Journal of Molecular Graphics and Modelling 19, 1:60 - 69, (2001).

  11. Modeling the Flexural Rigidity of Rod Photoreceptors

    PubMed Central

    Haeri, Mohammad; Knox, Barry E.; Ahmadi, Aphrodite

    2013-01-01

    In vertebrate eyes, the rod photoreceptor has a modified cilium with an extended cylindrical structure specialized for phototransduction called the outer segment (OS). The OS has numerous stacked membrane disks and can bend or break when subjected to mechanical forces. The OS exhibits axial structural variation, with extended bands composed of a few hundred membrane disks whose thickness is diurnally modulated. Using high-resolution confocal microscopy, we have observed OS flexing and disruption in live transgenic Xenopus rods. Based on the experimental observations, we introduce a coarse-grained model of OS mechanical rigidity using elasticity theory, representing the axial OS banding explicitly via a spring-bead model. We calculate a bending stiffness of ∼105 nN⋅μm2, which is seven orders-of-magnitude larger than that of typical cilia and flagella. This bending stiffness has a quadratic relation to OS radius, so that thinner OS have lower fragility. Furthermore, we find that increasing the spatial frequency of axial OS banding decreases OS rigidity, reducing its fragility. Moreover, the model predicts a tendency for OS to break in bands with higher spring number density, analogous to the experimental observation that transgenic rods tended to break preferentially in bands of high fluorescence. We discuss how pathological alterations of disk membrane properties by mutant proteins may lead to increased OS rigidity and thus increased breakage, ultimately contributing to retinal degeneration. PMID:23442852

  12. Origin of rigidity in dry granular solids.

    PubMed

    Sarkar, Sumantra; Bi, Dapeng; Zhang, Jie; Behringer, R P; Chakraborty, Bulbul

    2013-08-01

    Solids are distinguished from fluids by their ability to resist shear. In traditional solids, the resistance to shear is associated with the emergence of broken translational symmetry as exhibited by a nonuniform density pattern. In this work, we focus on the emergence of shear rigidity in a class of solids where this paradigm is challenged. Dry granular materials have no energetically or entropically preferred density modulations. We show that, in contrast to traditional solids, the emergence of shear rigidity in these granular solids is a collective process, which is controlled solely by boundary forces, the constraints of force and torque balance, and the positivity of the contact forces. We develop a theoretical framework based on these constraints, which connects rigidity to broken translational symmetry in the space of forces, not positions of grains. We apply our theory to experimentally generated shear-jammed states and show that these states are indeed characterized by a persistent, non-uniform density modulation in force space, which emerges at the shear-jamming transition.

  13. Permeability of Rigid Fibrous Refractory Insulations

    NASA Technical Reports Server (NTRS)

    Marschall, J.; Milos, F. S.; Rasky, Daniel J. (Technical Monitor)

    1996-01-01

    Rigid fibrous refractory insulations (TPS tiles) are integral components of many spacecraft thermal protection systems. These materials are composed of refractory fibers With diameters on the order of 1 to 15 micrometers. They are lightweight and have an open, highly porous microstructure. Typical densities are less than 500 kilograms per cubic meters, and porosities generally exceed 0.8. Because of their open porosity, these materials are permeable to gas glow. There are numerous instances in which internal gas transport in a thermal protection system could be important; examples include the penetration of hot boundary-layer gases into the insulation, the flow of decomposition (pyrolysis) products from the interior, the use of convective flows to mitigate ice formation caused by cryopumping, and the design of refractory vents for pressure equilibration during atmospheric entry. Computational analysis of gas flow through porous media requires values of permeability which have not previously been available for the rigid fibrous insulations used in thermal protection systems. This paper will document measurements of permeability for a variety of insulations from NASA's LI, FRCI, and AETB families of lightweight ceramic ablators. The directional anisotropy of permeability and its dependence on gas pressure and material density will be presented. It will be shown that rarified-flow effects are significant in the flow through such materials. Connections will be drawn between the insulation microstructure and permeability. The paper will also include representative computations of flow through rigid fibrous insulations.

  14. Machanistic basis of rigidity sensing at biological interfaces

    NASA Astrophysics Data System (ADS)

    Sarvestani, Alireza

    2011-03-01

    We have outlined a framework to investigate the thermodynamic equilibrium adhesion of a bio-membrane to a compliant substrate functionalized with immobilized bio-adhesive ligands. The membrane is modeled as a soft elastic shell, subjected to surface tension and reconstituted with mobile receptors and a repelling layer on the ventral side. The free energy function of the system is assumed to be comprised from the following contributions: the membrane--substrate non-specific interactions, stored elastic energy (in deformed membrane and substrate), binding enthalpy, and mixing entropy of mobile receptors. Assuming a van der Waals form for the interfacial non-specific potential, the equilibrium configuration of the system is studied in detail. We have shown that the equilibrium spread area of the adherent membrane is very sensitive to the rigidity of the underlying substrate and decreases as the surface compliance increases. This prediction is reminiscent of the experimental observations of spread area of cells attached to soft substrates. This is an interesting result considering the lack of contribution of intracellular signaling or actively regulated cytoskeleton in the proposed physical model for the adhesion. This suggests that the mechanistic pathways inherent to membrane--substrate thermodynamic interactions can be equally important as intracellular signaling pathways to mediate the process of rigidity sensing by cells.

  15. 49 CFR 587.18 - Dimensions of fixed rigid barrier.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 7 2012-10-01 2012-10-01 false Dimensions of fixed rigid barrier. 587.18 Section... Deformable Barrier § 587.18 Dimensions of fixed rigid barrier. (a) The fixed rigid barrier has a mass of not less than 7 × 104 kg (154,324 lb). (b) The height of the fixed rigid barrier is at least as high as...

  16. 49 CFR 587.18 - Dimensions of fixed rigid barrier.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 7 2014-10-01 2014-10-01 false Dimensions of fixed rigid barrier. 587.18 Section... Deformable Barrier § 587.18 Dimensions of fixed rigid barrier. (a) The fixed rigid barrier has a mass of not less than 7 × 104 kg (154,324 lb). (b) The height of the fixed rigid barrier is at least as high as...

  17. 49 CFR 587.18 - Dimensions of fixed rigid barrier.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 7 2013-10-01 2013-10-01 false Dimensions of fixed rigid barrier. 587.18 Section... Deformable Barrier § 587.18 Dimensions of fixed rigid barrier. (a) The fixed rigid barrier has a mass of not less than 7 × 104 kg (154,324 lb). (b) The height of the fixed rigid barrier is at least as high as...

  18. 30 CFR 57.11004 - Portable rigid ladders.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Portable rigid ladders. 57.11004 Section 57.11004 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL... Escapeways Travelways-Surface and Underground § 57.11004 Portable rigid ladders. Portable rigid ladders...

  19. 30 CFR 56.11004 - Portable rigid ladders.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Portable rigid ladders. 56.11004 Section 56.11004 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL....11004 Portable rigid ladders. Portable rigid ladders shall be provided with suitable bases and...

  20. 30 CFR 57.11004 - Portable rigid ladders.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Portable rigid ladders. 57.11004 Section 57.11004 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL... Escapeways Travelways-Surface and Underground § 57.11004 Portable rigid ladders. Portable rigid ladders...

  1. 30 CFR 56.11004 - Portable rigid ladders.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Portable rigid ladders. 56.11004 Section 56.11004 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL....11004 Portable rigid ladders. Portable rigid ladders shall be provided with suitable bases and...

  2. 21 CFR 876.5020 - External penile rigidity devices.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 8 2011-04-01 2011-04-01 false External penile rigidity devices. 876.5020 Section 876.5020 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES... maintain sufficient penile rigidity for sexual intercourse. External penile rigidity devices include...

  3. 21 CFR 876.5020 - External penile rigidity devices.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 8 2014-04-01 2014-04-01 false External penile rigidity devices. 876.5020 Section 876.5020 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES... maintain sufficient penile rigidity for sexual intercourse. External penile rigidity devices include...

  4. 21 CFR 876.5020 - External penile rigidity devices.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 8 2012-04-01 2012-04-01 false External penile rigidity devices. 876.5020 Section 876.5020 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES... maintain sufficient penile rigidity for sexual intercourse. External penile rigidity devices include...

  5. 21 CFR 886.5916 - Rigid gas permeable contact lens.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 8 2011-04-01 2011-04-01 false Rigid gas permeable contact lens. 886.5916 Section... (CONTINUED) MEDICAL DEVICES OPHTHALMIC DEVICES Therapeutic Devices § 886.5916 Rigid gas permeable contact lens. (a) Identification. A rigid gas permeable contact lens is a device intended to be worn...

  6. 21 CFR 886.5916 - Rigid gas permeable contact lens.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Rigid gas permeable contact lens. 886.5916 Section... (CONTINUED) MEDICAL DEVICES OPHTHALMIC DEVICES Therapeutic Devices § 886.5916 Rigid gas permeable contact lens. (a) Identification. A rigid gas permeable contact lens is a device intended to be worn...

  7. 49 CFR 587.18 - Dimensions of fixed rigid barrier.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 7 2010-10-01 2010-10-01 false Dimensions of fixed rigid barrier. 587.18 Section 587.18 Transportation Other Regulations Relating to Transportation (Continued) NATIONAL HIGHWAY... Deformable Barrier § 587.18 Dimensions of fixed rigid barrier. (a) The fixed rigid barrier has a mass of...

  8. 49 CFR 587.18 - Dimensions of fixed rigid barrier.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 7 2011-10-01 2011-10-01 false Dimensions of fixed rigid barrier. 587.18 Section 587.18 Transportation Other Regulations Relating to Transportation (Continued) NATIONAL HIGHWAY... Deformable Barrier § 587.18 Dimensions of fixed rigid barrier. (a) The fixed rigid barrier has a mass of...

  9. A Cognitive Developmental Model of Rigidity in Senescence.

    ERIC Educational Resources Information Center

    Lapsley, Daniel K.; Enright, Robert D.

    1983-01-01

    The rigidity construct is reinterpreted in terms of the cognitive developmental approach. A review reveals both cognitive and developmental themes, with an emphasis on the structural and operational properties of rigidity. Notes weaknesses of previous approaches to rigidity and discusses implications and predictions from the proposed model.…

  10. Nonlinear dynamic behavior of microscopic bubbles near a rigid wall

    NASA Astrophysics Data System (ADS)

    Suslov, Sergey A.; Ooi, Andrew; Manasseh, Richard

    2012-06-01

    The nonlinear dynamic behavior of microscopic bubbles near a rigid wall is investigated. Oscillations are driven by the ultrasonic pressure field that arises in various biomedical applications such as ultrasound imaging or targeted drug delivery. It is known that, when bubbles approach a blood-vessel wall, their linear dynamic response is modified. This modification may be very useful for real-time detection of bubbles that have found targets; in future therapeutic technologies, it may be useful for controlled release of medical agents encapsulating microbubbles. In this paper, the nonlinear response of microbubbles near a wall is studied. The Keller-Miksis-Parlitz equation is adopted, but modified to account for the presence of a rigid wall. This base model describes the time evolution of the bubble surface, which is assumed to remain spherical, and accounts for the effect of acoustic radiation losses owing to liquid compressibility in the momentum conservation. Two situations are considered: the base case of an isolated bubble in an unbounded medium, and a bubble near a rigid wall. In the latter case, the wall influence is modeled by including a symmetrically oscillating image bubble. The bubble dynamics is traced using a numerical solution of the model equation. Subsequently, Floquet theory is used to accurately detect the bifurcation point where bubble oscillations stop following the driving ultrasound frequency and undergo period-changing bifurcations. Of particular interest is the detection of the subcritical period-tripling and -quadrupling transition. The parametric bifurcation maps are obtained as functions of nondimensional parameters representing the bubble radius, the frequency and pressure amplitude of the driving ultrasound field, and the distance from the wall. It is shown that the presence of the wall generally stabilises the bubble dynamics, so that much larger values of the pressure amplitude are needed to generate nonlinear responses. Thus, a

  11. Probing bistability in Fe(II) and Co(II) complexes with an unsymmetrically substituted quinonoid ligand.

    PubMed

    van der Meer, Margarethe; Rechkemmer, Yvonne; Breitgoff, Frauke D; Dechert, Sebastian; Marx, Raphael; Dörfel, María; Neugebauer, Petr; van Slageren, Joris; Sarkar, Biprajit

    2016-05-28

    The generation of molecular platforms, the properties of which can be influenced by a variety of external perturbations, is an important goal in the field of functional molecular materials. We present here the synthesis of a new quinonoid ligand platform containing an [O,O,O,N] donor set. The ligand is derived from a chloranilic acid core by using the [NR] (nitrogen atom with a substituent R) for [O] isoelectronic substitution. Mononuclear Fe(II) and Co(II) complexes have been synthesized with this new ligand. Results obtained from single crystal X-ray crystallography, NMR spectroscopy, (spectro)electrochemistry, SQUID magnetometry, multi-frequency EPR spectroscopy and FIR spectroscopy are used to elucidate the electronic and geometric structures of the complexes. Furthermore, we show here that the spin state of the Fe(II) complex can be influenced by temperature, pressure and light and the Co(II) complex displays redox-induced spin-state switching. Bistability is observed in the solid-state as well as in solution for the Fe(II) complex. The new ligand presented here, owing to the [NR] group present in it, will likely have more adaptability while investigating switching phenomena compared to its [O,O,O,O] analogues. Thus, such classes of ligands as well as the results obtained on the reversible changes in physical properties of the metal complexes are likely to contribute to the generation of multifunctional molecular materials. PMID:27109712

  12. Single-Trial Classification of Bistable Perception by Integrating Empirical Mode Decomposition, Clustering, and Support Vector Machine

    NASA Astrophysics Data System (ADS)

    Wang, Zhisong; Maier, Alexander; Logothetis, Nikos K.; Liang, Hualou

    2008-12-01

    We propose an empirical mode decomposition (EMD-) based method to extract features from the multichannel recordings of local field potential (LFP), collected from the middle temporal (MT) visual cortex in a macaque monkey, for decoding its bistable structure-from-motion (SFM) perception. The feature extraction approach consists of three stages. First, we employ EMD to decompose nonstationary single-trial time series into narrowband components called intrinsic mode functions (IMFs) with time scales dependent on the data. Second, we adopt unsupervised K-means clustering to group the IMFs and residues into several clusters across all trials and channels. Third, we use the supervised common spatial patterns (CSP) approach to design spatial filters for the clustered spatiotemporal signals. We exploit the support vector machine (SVM) classifier on the extracted features to decode the reported perception on a single-trial basis. We demonstrate that the CSP feature of the cluster in the gamma frequency band outperforms the features in other frequency bands and leads to the best decoding performance. We also show that the EMD-based feature extraction can be useful for evoked potential estimation. Our proposed feature extraction approach may have potential for many applications involving nonstationary multivariable time series such as brain-computer interfaces (BCI).

  13. Expandable and rigid endorectal coils for prostate MRI: impact on prostate distortion and rigid image registration.

    PubMed

    Kim, Yongbok; Hsu, I-Chow J; Pouliot, Jean; Noworolski, Susan Moyher; Vigneron, Daniel B; Kurhanewicz, John

    2005-12-01

    Endorectal coils (ERCs) are used for acquiring high spatial resolution magnetic resonance (MR) images of the human prostate. The goal of this study is to determine the impact of an expandable versus a rigid ERC on changes in the location and deformation of the prostate gland and subsequently on registering prostate images acquired with and without an ERC. Sagittal and axial T2 weighted MR images were acquired from 25 patients receiving a combined MR imaging/MR spectroscopic imaging staging exam for prostate cancer. Within the same exam, images were acquired using an external pelvic phased array coil both alone and in combination with either an expandable ERC (MedRad, Pittsburgh, PA) or a rigid ERC (USA Instruments, Aurora, OH). Rotations, translations and deformations caused by the ERC were measured and compared. The ability to register images acquired with and without the ERC using a manual rigid-body registration was assessed using a similarity index (SI). Both ERCs caused the prostate to tilt anteriorly with an average tilt of 18.5 degrees (17.4 +/- 9.9 and 19.5 +/- 11.3 degrees, mean +/- standard deviation, for expandable and rigid ERC, respectively). However, the expandable coil caused a significantly larger distortion of the prostate as compared to the rigid coil; compressing the prostate in the anterior/posterior direction by 4.1 +/- 3.0 mm vs 1.2 +/- 2.2 mm (14.5% vs 4.8%) (p < 0.0001), and widening the prostate in the right/left direction by 3.8 +/- 3.7 mm vs 1.5 +/- 3.1 mm (8.3% vs 3.4%) (p = 0.004). Additionally, the ability to manually align prostate images acquired with and without ERC was significantly (p < 0.0001) better for the rigid coil (SI = 0.941 +/- 0.008 vs 0.899 +/- 0.033, for the rigid and expandable coils, respectively). In conclusion, the manual rigid-body alignment of prostate MR images acquired with and without the ERC can be improved through the use of a rigid ERC. PMID:16475755

  14. Stochastic dynamics and non-equilibrium thermodynamics of a bistable chemical system: the Schlögl model revisited.

    PubMed

    Vellela, Melissa; Qian, Hong

    2009-10-01

    Schlögl's model is the canonical example of a chemical reaction system that exhibits bistability. Because the biological examples of bistability and switching behaviour are increasingly numerous, this paper presents an integrated deterministic, stochastic and thermodynamic analysis of the model. After a brief review of the deterministic and stochastic modelling frameworks, the concepts of chemical and mathematical detailed balances are discussed and non-equilibrium conditions are shown to be necessary for bistability. Thermodynamic quantities such as the flux, chemical potential and entropy production rate are defined and compared across the two models. In the bistable region, the stochastic model exhibits an exchange of the global stability between the two stable states under changes in the pump parameters and volume size. The stochastic entropy production rate shows a sharp transition that mirrors this exchange. A new hybrid model that includes continuous diffusion and discrete jumps is suggested to deal with the multiscale dynamics of the bistable system. Accurate approximations of the exponentially small eigenvalue associated with the time scale of this switching and the full time-dependent solution are calculated using Matlab. A breakdown of previously known asymptotic approximations on small volume scales is observed through comparison with these and Monte Carlo results. Finally, in the appendix section is an illustration of how the diffusion approximation of the chemical master equation can fail to represent correctly the mesoscopically interesting steady-state behaviour of the system.

  15. Frequency-induced polarization bistability in vertical-cavity surface-emitting lasers with orthogonal optical injection

    SciTech Connect

    Gatare, I.; Panajotov, K.; Sciamanna, M.

    2007-02-15

    We report theoretically on a pure frequency-induced polarization bistability in a vertical-cavity surface-emitting laser (VCSEL) subject to orthogonal optical injection, i.e., the master laser light polarization is orthogonal to that of the slave VCSEL. As the frequency detuning is scanned from negative to positive values and for a fixed injected power, the VCSEL exhibits two successive and possibly bistable polarization switchings. The first switching (from the slave laser polarization to the injected light polarization) exhibits a bistable region whose width is maximum for a given value of the injected power. Such a dependency of hysteresis width on the injected power is similar to that recently found experimentally by Hong et al.[Electron. Lett. 36, 2019 (2000)]. The bistability accompanying the second switching (from the injected light polarization back to the slave laser free-running polarization) exhibits, however, significantly different features related to the occurrence of optical chaos. Interestingly, the width of the bistable region can be tuned over a large range not only by modifying the injection parameters but also by modifying the device parameters, in particular the VCSEL linewidth enhancement factor.

  16. Exploring local flexibility/rigidity in psychrophilic and mesophilic carbonic anhydrases.

    PubMed

    Chiuri, R; Maiorano, G; Rizzello, A; del Mercato, L L; Cingolani, R; Rinaldi, R; Maffia, M; Pompa, P P

    2009-02-18

    Molecular flexibility and rigidity are required to determine the function and specificity of protein molecules. Some psychrophilic enzymes demonstrate a higher catalytic efficiency at low temperatures, compared to the efficiency demonstrated by their meso/thermophilic homologous. The emerging picture suggests that such enzymes have an improved flexibility of the structural catalytic components, whereas other protein regions far from functional sites may be even more rigid than those of their mesophilic counterparts. To gain a deeper insight in the analysis of the activity-flexibility/rigidity relationship in protein structure, psychrophilic carbonic anhydrase of the Antarctic teleost Chionodraco hamatus has been compared with carbonic anhydrase II of Bos taurus through fluorescence studies, three-dimensional modeling, and activity analyses. Data demonstrated that the cold-adapted enzyme exhibits an increased catalytic efficiency at low and moderate temperatures and, more interestingly, a local flexibility in the region that controls the correct folding of the catalytic architecture, as well as a rigidity in the hydrophobic core. The opposite result was observed in the mesophilic counterpart. These results suggest a clear relationship between the activity and the presence of flexible and rigid protein substructures that may be useful in rational molecular and drug design of a class of enzymes playing a key role in pathologic processes.

  17. Population Density Modulates Drug Inhibition and Gives Rise to Potential Bistability of Treatment Outcomes for Bacterial Infections

    PubMed Central

    Maltas, Jeff; Brumm, Peter; Wood, Kevin B.

    2016-01-01

    The inoculum effect (IE) is an increase in the minimum inhibitory concentration (MIC) of an antibiotic as a function of the initial size of a microbial population. The IE has been observed in a wide range of bacteria, implying that antibiotic efficacy may depend on population density. Such density dependence could have dramatic effects on bacterial population dynamics and potential treatment strategies, but explicit measures of per capita growth as a function of density are generally not available. Instead, the IE measures MIC as a function of initial population size, and population density changes by many orders of magnitude on the timescale of the experiment. Therefore, the functional relationship between population density and antibiotic inhibition is generally not known, leaving many questions about the impact of the IE on different treatment strategies unanswered. To address these questions, here we directly measured real-time per capita growth of Enterococcus faecalis populations exposed to antibiotic at fixed population densities using multiplexed computer-automated culture devices. We show that density-dependent growth inhibition is pervasive for commonly used antibiotics, with some drugs showing increased inhibition and others decreased inhibition at high densities. For several drugs, the density dependence is mediated by changes in extracellular pH, a community-level phenomenon not previously linked with the IE. Using a simple mathematical model, we demonstrate how this density dependence can modulate population dynamics in constant drug environments. Then, we illustrate how time-dependent dosing strategies can mitigate the negative effects of density-dependence. Finally, we show that these density effects lead to bistable treatment outcomes for a wide range of antibiotic concentrations in a pharmacological model of antibiotic treatment. As a result, infections exceeding a critical density often survive otherwise effective treatments. PMID:27764095

  18. Understanding geological processes: Visualization of rigid and non-rigid transformations

    NASA Astrophysics Data System (ADS)

    Shipley, T. F.; Atit, K.; Manduca, C. A.; Ormand, C. J.; Resnick, I.; Tikoff, B.

    2012-12-01

    Visualizations are used in the geological sciences to support reasoning about structures and events. Research in cognitive sciences offers insights into the range of skills of different users, and ultimately how visualizations might support different users. To understand the range of skills needed to reason about earth processes we have developed a program of research that is grounded in the geosciences' careful description of the spatial and spatiotemporal patterns associated with earth processes. In particular, we are pursuing a research program that identifies specific spatial skills and investigates whether and how they are related to each other. For this study, we focus on a specific question: Is there an important distinction in the geosciences between rigid and non-rigid deformation? To study a general spatial thinking skill we employed displays with non-geological objects that had been altered by rigid change (rotation), and two types of non-rigid change ("brittle" (or discontinuous) and "ductile" (or continuous) deformation). Disciplinary scientists (geosciences and chemistry faculty), and novices (non-science faculty and undergraduate psychology students) answered questions that required them to visualize the appearance of the object before the change. In one study, geologists and chemists were found to be superior to non-science faculty in reasoning about rigid rotations (e.g., what an object would look like from a different perspective). Geologists were superior to chemists in reasoning about brittle deformations (e.g., what an object looked like before it was broken - here the object was a word cut into many fragments displaced in different directions). This finding is consistent with two hypotheses: 1) Experts are good at visualizing the types of changes required for their domain; and 2) Visualization of rigid and non-rigid changes are not the same skill. An additional important finding is that there was a broad range of skill in both rigid and non-rigid

  19. Rigid and non-rigid micro-plates: Philippines and Myanmar-Andaman case studies

    NASA Astrophysics Data System (ADS)

    Rangin, Claude

    2016-01-01

    Generally, tectonic plates are considered as rigid. Oblique plate convergence favors the development of micro-plates along the converging boundaries. The north-south-trending Philippines archipelago (here named Philippine Mobile Belt, PMB), a few hundreds kilometers wide, is one of such complex tectonic zones. We show here that it is composed of rigid rotating crustal blocks (here called platelets). In Myanmar, the northernmost tip of the Sumatra-Andaman subduction system is another complex zone made of various crustal blocks in-between convergent plates. Yet, contrary to PMB, it sustains internal deformation with platelet buckling, altogether indicative of a non-rigid behavior. Therefore, the two case studies, Philippine Mobile Belt and Myanmar-Andaman micro-plate (MAS), illustrate the complexity of micro-plate tectonics and kinematics at convergent plate boundaries.

  20. A Statistical Mechanics Approach for a Rigidity Problem

    NASA Astrophysics Data System (ADS)

    Mesón, Alejandro; Vericat, Fernando

    2007-01-01

    We focus the problem of establishing when a statistical mechanics system is determined by its free energy. A lattice system, modelled by a directed and weighted graph G (whose vertices are the spins and its adjacency matrix M will be given by the system transition rules), is considered. For a matrix A( q), depending on the system interactions, with entries which are in the ring Z[ a q : a∈ R +] and such that A(0) equals the integral matrix M, the system free energy β A ( q) will be defined as the spectral radius of A( q). This kind of free energy will be related with that normally introduced in Statistical Mechanics as proportional to the logarithm of the partition function. Then we analyze under what conditions the following statement could be valid: if two systems have respectively matrices A, B and β A = β B then the matrices are equivalent in some sense. Issues of this nature receive the name of rigidity problems. Our scheme, for finite interactions, closely follows that developed, within a dynamical context, by Pollicott and Weiss but now emphasizing their statistical mechanics aspects and including a classification for Gibbs states associated to matrices A( q). Since this procedure is not applicable for infinite range interactions, we discuss a way to obtain also some rigidity results for long range potentials.

  1. Extracellular rigidity sensing by talin isoform–specific mechanical linkages

    PubMed Central

    Austen, Katharina; Ringer, Pia; Mehlich, Alexander; Chrostek-Grashoff, Anna; Kluger, Carleen; Klingner, Christoph; Sabass, Benedikt; Zent, Roy; Rief, Matthias; Grashoff, Carsten

    2015-01-01

    The ability of cells to adhere and sense differences in tissue stiffness is crucial for organ development and function. The central mechanisms by which adherent cells detect extracellular matrix compliance, however, are still unknown. Using two single-molecule–calibrated biosensors that allow the analysis of a previously inaccessible but physiologically highly relevant force regime in cells, we demonstrate that the integrin activator talin establishes mechanical linkages upon cell adhesion, which are indispensable for cells to probe tissue stiffness. Talin linkages are exposed to a range of piconewton (pN) forces and bear, on average, 7–10 pN during cell adhesion depending on their association with f-actin and vinculin. Disruption of talin’s mechanical engagement does not impair integrin activation and initial cell adhesion but prevents focal adhesion reinforcement and thus extracellular rigidity sensing. Intriguingly, talin mechanics are isoform-specific so that expression of either talin-1 or talin-2 modulates extracellular rigidity sensing. PMID:26523364

  2. Brownian dynamics of confined rigid bodies.

    PubMed

    Delong, Steven; Balboa Usabiaga, Florencio; Donev, Aleksandar

    2015-10-14

    We introduce numerical methods for simulating the diffusive motion of rigid bodies of arbitrary shape immersed in a viscous fluid. We parameterize the orientation of the bodies using normalized quaternions, which are numerically robust, space efficient, and easy to accumulate. We construct a system of overdamped Langevin equations in the quaternion representation that accounts for hydrodynamic effects, preserves the unit-norm constraint on the quaternion, and is time reversible with respect to the Gibbs-Boltzmann distribution at equilibrium. We introduce two schemes for temporal integration of the overdamped Langevin equations of motion, one based on the Fixman midpoint method and the other based on a random finite difference approach, both of which ensure that the correct stochastic drift term is captured in a computationally efficient way. We study several examples of rigid colloidal particles diffusing near a no-slip boundary and demonstrate the importance of the choice of tracking point on the measured translational mean square displacement (MSD). We examine the average short-time as well as the long-time quasi-two-dimensional diffusion coefficient of a rigid particle sedimented near a bottom wall due to gravity. For several particle shapes, we find a choice of tracking point that makes the MSD essentially linear with time, allowing us to estimate the long-time diffusion coefficient efficiently using a Monte Carlo method. However, in general, such a special choice of tracking point does not exist, and numerical techniques for simulating long trajectories, such as the ones we introduce here, are necessary to study diffusion on long time scales. PMID:26472363

  3. Brownian dynamics of confined rigid bodies

    NASA Astrophysics Data System (ADS)

    Delong, Steven; Balboa Usabiaga, Florencio; Donev, Aleksandar

    2015-10-01

    We introduce numerical methods for simulating the diffusive motion of rigid bodies of arbitrary shape immersed in a viscous fluid. We parameterize the orientation of the bodies using normalized quaternions, which are numerically robust, space efficient, and easy to accumulate. We construct a system of overdamped Langevin equations in the quaternion representation that accounts for hydrodynamic effects, preserves the unit-norm constraint on the quaternion, and is time reversible with respect to the Gibbs-Boltzmann distribution at equilibrium. We introduce two schemes for temporal integration of the overdamped Langevin equations of motion, one based on the Fixman midpoint method and the other based on a random finite difference approach, both of which ensure that the correct stochastic drift term is captured in a computationally efficient way. We study several examples of rigid colloidal particles diffusing near a no-slip boundary and demonstrate the importance of the choice of tracking point on the measured translational mean square displacement (MSD). We examine the average short-time as well as the long-time quasi-two-dimensional diffusion coefficient of a rigid particle sedimented near a bottom wall due to gravity. For several particle shapes, we find a choice of tracking point that makes the MSD essentially linear with time, allowing us to estimate the long-time diffusion coefficient efficiently using a Monte Carlo method. However, in general, such a special choice of tracking point does not exist, and numerical techniques for simulating long trajectories, such as the ones we introduce here, are necessary to study diffusion on long time scales.

  4. Brownian dynamics of confined rigid bodies

    SciTech Connect

    Delong, Steven; Balboa Usabiaga, Florencio; Donev, Aleksandar

    2015-10-14

    We introduce numerical methods for simulating the diffusive motion of rigid bodies of arbitrary shape immersed in a viscous fluid. We parameterize the orientation of the bodies using normalized quaternions, which are numerically robust, space efficient, and easy to accumulate. We construct a system of overdamped Langevin equations in the quaternion representation that accounts for hydrodynamic effects, preserves the unit-norm constraint on the quaternion, and is time reversible with respect to the Gibbs-Boltzmann distribution at equilibrium. We introduce two schemes for temporal integration of the overdamped Langevin equations of motion, one based on the Fixman midpoint method and the other based on a random finite difference approach, both of which ensure that the correct stochastic drift term is captured in a computationally efficient way. We study several examples of rigid colloidal particles diffusing near a no-slip boundary and demonstrate the importance of the choice of tracking point on the measured translational mean square displacement (MSD). We examine the average short-time as well as the long-time quasi-two-dimensional diffusion coefficient of a rigid particle sedimented near a bottom wall due to gravity. For several particle shapes, we find a choice of tracking point that makes the MSD essentially linear with time, allowing us to estimate the long-time diffusion coefficient efficiently using a Monte Carlo method. However, in general, such a special choice of tracking point does not exist, and numerical techniques for simulating long trajectories, such as the ones we introduce here, are necessary to study diffusion on long time scales.

  5. Rigid and flexible OLEDs: prototypes to applications

    NASA Astrophysics Data System (ADS)

    Monz, Stefan; Wolf, Konrad; Möbius, Hildegard; Blankenbach, Karlheinz

    2011-03-01

    Major achievements of this research project on rigid and flexible OLEDs are: lifetime enhancement by advanced constant luminance (L) operation, integration into textiles and furthermore, the prototype production on flexible PET/ITO substrates of polymer OLEDs. Our OLEDs were manufactured with spin-coating assisted by ink-jet printing. We introduced constant luminance operation (instead of the usual constant current) which was implemented in order to extend the overall lifetime of OLEDs. A threefold lifetime improvement was achieved by maintaining 50% luminance using an advanced microcontroller-based lifetime(LT) model. Various approaches to textile integration and evaluation of environmental issues in clothes (e.g. moisture) were investigated.

  6. Edge shape and comfort of rigid lenses.

    PubMed

    La Hood, D

    1988-08-01

    One of the main factors determining the comfort of a rigid contact lens is the shape of the edge. The comfort of four different contact lens edge shapes was assessed with four unadapted subjects in a randomized masked trial. Lenses with well rounded anterior edge profiles were found to be significantly more comfortable than lenses with square anterior edges. There was no significant difference in subjective comfort between a rounded and square posterior edge profile. The results suggest that the interaction of the edge with the eyelid is more important in determining comfort than edge effects on the cornea, when lenses are fitted according to a corneal alignment philosophy. PMID:3177585

  7. The High Rigidity Spectrometer for FRIB

    NASA Astrophysics Data System (ADS)

    Baumann, T.

    2016-06-01

    The High Rigidity Spectrometer (HRS) is being developed to make optimum use of the fast rare-isotope beams that will be available at the Facility for Rare-Isotope Beams (FRIB) and will be the key experimental tool to study the most exotic, neutron-rich nuclei. The HRS will accommodate detector systems for charged particles, neutrons, and gamma rays. This will enable coincidence measurements of reaction products that stem from a variety of reactions such as knockout, breakup, charge exchange or Coulomb excitation. First-order ion optical studies are under way and this paper will offer some details on the current design ideas.

  8. Mechanical Characterization of Rigid Polyurethane Foams

    SciTech Connect

    Lu, Wei-Yang

    2014-12-01

    Foam materials are used to protect sensitive components from impact loading. In order to predict and simulate the foam performance under various loading conditions, a validated foam model is needed and the mechanical properties of foams need to be characterized. Uniaxial compression and tension tests were conducted for different densities of foams under various temperatures and loading rates. Crush stress, tensile strength, and elastic modulus were obtained. A newly developed confined compression experiment provided data for investigating the foam flow direction. A biaxial tension experiment was also developed to explore the damage surface of a rigid polyurethane foam.

  9. On the origin of bistability in the Stage 2 of the Huang-Ferrell model of the MAPK signaling

    NASA Astrophysics Data System (ADS)

    Hadač, O.; Schreiber, I.; Přibyl, M.

    2013-02-01

    Mitogen-activated protein kinases (MAPKs) are important signal transducing enzymes, unique to eukaryotes, that are involved in many pathways of cellular regulation. Successive phosphorylation cascades mediated by MAPKs serve as sensitive switches initiating various cellular processes. Apart from this basic feature, the underlying reaction network is capable of displaying other nonlinear phenomena including bistable steady states and hysteresis as well as periodic oscillations. We show that from the mechanistic point of view, bistability is a consequence of interaction between single and double phosphorylation/dephosphorylation pathways in a Stage 2 subsystem of the Huang-Ferrell model. Within this subsystem we uncover the core subnetwork obtained by systematic reduction relying on the methods of stoichiometric network analysis. For the core model we show that there is either one stable steady state or three steady states of which two are stable and point out the role of interplay between the single and double phosphorylation subnetworks in generating bistability.

  10. Flexural rigidity of microtubules and actin filaments measured from thermal fluctuations in shape

    PubMed Central

    1993-01-01

    Microtubules are long, proteinaceous filaments that perform structural functions in eukaryotic cells by defining cellular shape and serving as tracks for intracellular motor proteins. We report the first accurate measurements of the flexural rigidity of microtubules. By analyzing the thermally driven fluctuations in their shape, we estimated the mean flexural rigidity of taxol-stabilized microtubules to be 2.2 x 10(-23) Nm2 (with 6.4% uncertainty) for seven unlabeled microtubules and 2.1 x 10(-23) Nm2 (with 4.7% uncertainty) for eight rhodamine-labeled microtubules. These values are similar to earlier, less precise estimates of microtubule bending stiffness obtained by modeling flagellar motion. A similar analysis on seven rhodamine-phalloidin- labeled actin filaments gave a flexural rigidity of 7.3 x 10(-26) Nm2 (with 6% uncertainty), consistent with previously reported results. The flexural rigidity of these microtubules corresponds to a persistence length of 5,200 microns showing that a microtubule is rigid over cellular dimensions. By contrast, the persistence length of an actin filament is only approximately 17.7 microns, perhaps explaining why actin filaments within cells are usually cross-linked into bundles. The greater flexural rigidity of a microtubule compared to an actin filament mainly derives from the former's larger cross-section. If tubulin were homogeneous and isotropic, then the microtubule's Young's modulus would be approximately 1.2 GPa, similar to Plexiglas and rigid plastics. Microtubules are expected to be almost inextensible: the compliance of cells is due primarily to filament bending or sliding between filaments rather than the stretching of the filaments themselves. PMID:8432732

  11. Unilateral Subthalamic Nucleus Stimulation Has a Measurable Ipsilateral Effect on Rigidity And Bradykinesia in Parkinson Disease

    PubMed Central

    Tabbal, Samer D.; Ushe, Mwiza; Mink, Jonathan W.; Revilla, Fredy J.; Wernle, Angie R.; Hong, Minna; Karimi, Morvarid; Perlmutter, Joel S.

    2008-01-01

    Background Bilateral deep brain stimulation (DBS) of the subthalamic nucleus (STN) improves motor function in Parkinson disease (PD). However, little is known about the quantitative effects on motor behavior of unilateral STN DBS. Methods In 52 PD subjects with STN DBS, we quantified in a double-blinded manner rigidity (n= 42), bradykinesia (n= 38), and gait speed (n= 45). Subjects were tested in four DBS conditions: both on, left on, right on and both off. A force transducer was used to measure rigidity across the elbow, and gyroscopes were used to measure angular velocity of hand rotations for bradykinesia. About half of the subjects were rated using the Unified Parkinson Disease Rating Scale (part III) motor scores for arm rigidity and repetitive hand rotation simultaneously during the kinematic measurements. Subjects were timed walking 25 feet. Results All subjects had significant improvement with bilateral STN DBS. Contralateral, ipsilateral and bilateral stimulation significantly reduced rigidity and bradykinesia. Bilateral stimulation improved rigidity more than unilateral stimulation of either side, but there was no significant difference between ipsilateral and contralateral stimulation. Although bilateral stimulation also increased hand rotation velocity more than unilateral stimulation of either side, contralateral stimulation increased hand rotation significantly more than ipsilateral stimulation. All stimulation conditions improved walking time but bilateral stimulation provided the greatest improvement. Conclusions Unilateral STN DBS decreased rigidity and bradykinesia contralaterally as well ipsilaterally. As expected, bilateral DBS improved gait more than unilateral DBS. These findings suggest that unilateral STN DBS alters pathways that affect rigidity and bradykinesia bilaterally but do not support the clinical use of unilateral STN DBS since bilateral DBS clearly provides greater benefit. PMID:18329019

  12. Frustrated bistability as a means to engineer oscillations in biological systems

    NASA Astrophysics Data System (ADS)

    Krishna, S.; Semsey, S.; Jensen, M. H.

    2009-09-01

    Oscillations play an important physiological role in a variety of biological systems. For example, respiration and carbohydrate synthesis are coupled to the circadian clock in cyanobacteria (Ishiura et al 1998 Science 281 1519) and ultradian oscillations with time periods of a few hours have been observed in immune response (NF-κB, Hoffmann et al 2002 Science 298 1241, Neson et al 2004 Science 306 704), apoptosis (p53, Lahav et al 2004 Nat. Genet. 36 53), development (Hes, Hirata et al 2002 Science 298 840) and growth hormone secretion (Plotsky and Vale 1985 Science 230 461, Zeitler et al 1991 Proc. Natl. Acad. Sci. USA 88 8920). Here we discuss how any bistable system can be 'frustrated' to produce oscillations of a desired nature—we use the term frustration, in analogy to frustrated spins in antiferromagnets, to refer to the addition of a negative feedback loop that destabilizes the bistable system. We show that the molecular implementation can use a wide variety of methods ranging from translation regulation, using small non-coding RNAs, to targeted protein modification to transcriptional regulation. We also introduce a simple graphical method for determining whether a particular implementation will produce oscillations. The shape of the resulting oscillations can be readily tuned to produce spiky and asymmetric oscillations—quite different from the shapes produced by synthetic oscillators (Elowitz and Leibler 2000 Nature 403 335, Fung et al 2005 Nature 435 118). The time period and amplitude can also be manipulated and these oscillators are easy to reset or switch on and off using a tunable external input. The mechanism of frustrated bistability could thus prove to be an easily implementable way to synthesize flexible, designable oscillators.

  13. A constitutive theory for rigid polyurethane foam

    SciTech Connect

    Neilsen, M.K.; Krieg, R.D.; Schreyer, H.L.

    1992-12-31

    Rigid, closed-cell, polyurethane foam consists of interconnected polyurethane plates which form cells. When this foam is compressed, it exhibits an initial elastic regime which is followed by a plateau regime in which the load required to compress the foam remains nearly constant. In the plateau regime, cell walls are damaged and large permanent volume changes are generated. As additional load is applied, cell walls are compressed against neighboring cell walls, and the stiffness of the foam increases and approaches a value equal to that of solid polyurethane. When the foam is loaded in tension, the cell walls are damaged and the foam fractures. A constitutive theory for rigid polyurethane foam has been developed. This theory is based on a decomposition of the foam into two parts: a skeleton and a nonlinear elastic continuum in parallel. The skeleton accounts for the foam behavior in the elastic and plateau regimes and is described using a coupled plasticity with continuum damage theory. The nonlinear elastic continuum accounts for the lock-up of the foam due to internal gas pressure and cell wall interactions. This new constitutive theory has been implemented in both static and dynamic finite element codes. Numerical simulations performed using the new constitutive theory are presented.

  14. Fast collision detection for fracturing rigid bodies.

    PubMed

    Glondu, Loeiz; Schvartzman, Sara C; Marchal, Maud; Dumont, Georges; Otaduy, Miguel A

    2014-01-01

    In complex scenes with many objects, collision detection plays a key role in the simulation performance. This is particularly true in fracture simulation for two main reasons. One is that fracture fragments tend to exhibit very intensive contact, and the other is that collision detection data structures for new fragments need to be computed on the fly. In this paper, we present novel collision detection algorithms and data structures for real-time simulation of fracturing rigid bodies. We build on a combination of well-known efficient data structures, namely, distance fields and sphere trees, making our algorithm easy to integrate on existing simulation engines. We propose novel methods to construct these data structures, such that they can be efficiently updated upon fracture events and integrated in a simple yet effective self-adapting contact selection algorithm. Altogether, we drastically reduce the cost of both collision detection and collision response. We have evaluated our global solution for collision detection on challenging scenarios, achieving high frame rates suited for hard real-time applications such as video games or haptics. Our solution opens promising perspectives for complex fracture simulations involving many dynamically created rigid objects. PMID:24201324

  15. Fast Collision Detection for Fracturing Rigid Bodies.

    PubMed

    Glondu, Loeiz; Schvartzman, Sara C; Marchal, Maud; Dumont, Georges; Otaduy, Miguel A

    2013-07-01

    In complex scenes with many objects, collision detection plays a key role in the simulation performance. This is particularly true in fracture simulation for two main reasons. One is that fracture fragments tend to exhibit very intensive contact, and the other is that collision detection data structures for new fragments need to be computed on the fly. In this paper, we present novel collision detection algorithms and data structures for real-time simulation of fracturing rigid bodies. We build on a combination of well-known efficient data structures, namely distance fields and sphere trees, making our algorithm easy to integrate on existing simulation engines. We propose novel methods to construct these data structures, such that they can be efficiently updated upon fracture events and integrated in a simple yet effective self-adapting contact selection algorithm. Altogether, we drastically reduce the cost of both collision detection and collision response. We have evaluated our global solution for collision detection on challenging scenarios, achieving high frame rates suited for hard real-time applications such as video games or haptics. Our solution opens promising perspectives for complex fracture simulations involving many dynamically created rigid objects. PMID:23836702

  16. Bistability in pulse propagation in networks of excitatory and inhibitory populations.

    PubMed

    Golomb, D; Ermentrout, G B

    2001-04-30

    We study the propagation of traveling solitary pulses in one-dimensional networks of excitatory and inhibitory integrate-and-fire neurons. Slow pulses, during which inhibitory cells fire well before neighboring excitatory cells, can propagate along the network at intermediate inhibition levels. At higher levels, they destabilize via a Hopf bifurcation. There is a bistable parameter regime in which both fast and slow pulses can propagate. Lurching pulses with spatiotemporal periodicity can propagate in regimes for which continuous pulses do not exist. PMID:11328125

  17. Surface plasmon-assisted optical bistability in the quantum dot-metal nanoparticle hybrid system

    NASA Astrophysics Data System (ADS)

    Bao, Chengjun; Qi, Yihong; Niu, Yueping; Gong, Shangqing

    2016-07-01

    We theoretically investigated optical bistability (OB) of a coupled excition-plasmon hybrid system in a unidirectional ring cavity. It is found that the threshold and the region of OB can be tuned by adjusting the center-center distance between the quantum dot and metal nanoparticle (MNP), the Rabi frequency of the control field and the radius of the MNP. Due to the significantly enhanced optical nonlinearity by the surface plasmon effect, the threshold of OB can be decreased greatly when the probe field is parallel to the major axis of the hybrid system. The enhanced OB may have promising applications in optical switching and optical storage.

  18. Bistability and State Transition of a Delay Differential Equation Model of Neutrophil Dynamics

    NASA Astrophysics Data System (ADS)

    Ma, Suqi; Zhu, Kaiyi; Lei, Jinzhi

    This paper studies the existence of bistable states and control strategies to induce state transitions of a delay differential equation model of neutrophil dynamics. We seek the conditions that a stable steady state and an oscillatory state coexist in the neutrophil dynamical system. Physiologically, stable steady state represents the healthy state, while oscillatory state is usually associated with diseases such as cyclical neutropenia. We study the control strategies to induce the transitions from the disease state to the healthy state by introducing temporal perturbations to system parameters. This study is valuable in designing clinical protocols for the treatment of cyclical neutropenia.

  19. Method and apparatus for bistable optical information storage for erasable optical disks

    DOEpatents

    Land, Cecil E.; McKinney, Ira D.

    1990-01-01

    A method and an optical device for bistable storage of optical information, together with reading and erasure of the optical information, using a photoactivated shift in a field dependent phase transition between a metastable or a bias-stabilized ferroelectric (FE) phase and a stable antiferroelectric (AFE) phase in an lead lanthanum zirconate titanate (PLZT). An optical disk contains the PLZT. Writing and erasing of optical information can be accomplished by a light beam normal to the disk. Reading of optical information can be accomplished by a light beam at an incidence angle of 15 to 60 degrees to the normal of the disk.

  20. Method and apparatus for bistable optical information storage for erasable optical disks

    DOEpatents

    Land, C.E.; McKinney, I.D.

    1988-05-31

    A method and an optical device for bistable storage of optical information, together with reading and erasure of the optical information, using a photoactivated shift in a field dependent phase transition between a metastable or a bias-stabilized ferroelectric (FE) phase and a stable antiferroelectric (AFE) phase in a lead lanthanum zirconate titanate (PLZT). An optical disk contains the PLZT. Writing and erasing of optical information can be accomplished by a light beam normal to the disk. Reading of optical information can be accomplished by a light beam at an incidence angle of 15 to 60 degrees to the normal of the disk. 10 figs.