No regularity singularities exist at points of general relativistic shock wave interaction between shocks from different characteristic families.

PubMed

Reintjes, Moritz; Temple, Blake

2015-05-08

We give a constructive proof that coordinate transformations exist which raise the regularity of the gravitational metric tensor from C 0,1 to C 1,1 in a neighbourhood of points of shock wave collision in general relativity. The proof applies to collisions between shock waves coming from different characteristic families, in spherically symmetric spacetimes. Our result here implies that spacetime is locally inertial and corrects an error in our earlier Proc. R. Soc. A publication, which led us to the false conclusion that such coordinate transformations, which smooth the metric to C 1,1 , cannot exist. Thus, our result implies that regularity singularities (a type of mild singularity introduced in our Proc. R. Soc. A paper) do not exist at points of interacting shock waves from different families in spherically symmetric spacetimes. Our result generalizes Israel's celebrated 1966 paper to the case of such shock wave interactions but our proof strategy differs fundamentally from that used by Israel and is an extension of the strategy outlined in our original Proc. R. Soc. A publication. Whether regularity singularities exist in more complicated shock wave solutions of the Einstein-Euler equations remains open.

No regularity singularities exist at points of general relativistic shock wave interaction between shocks from different characteristic families

PubMed Central

Reintjes, Moritz; Temple, Blake

2015-01-01

We give a constructive proof that coordinate transformations exist which raise the regularity of the gravitational metric tensor from C0,1 to C1,1 in a neighbourhood of points of shock wave collision in general relativity. The proof applies to collisions between shock waves coming from different characteristic families, in spherically symmetric spacetimes. Our result here implies that spacetime is locally inertial and corrects an error in our earlier Proc. R. Soc. A publication, which led us to the false conclusion that such coordinate transformations, which smooth the metric to C1,1, cannot exist. Thus, our result implies that regularity singularities (a type of mild singularity introduced in our Proc. R. Soc. A paper) do not exist at points of interacting shock waves from different families in spherically symmetric spacetimes. Our result generalizes Israel's celebrated 1966 paper to the case of such shock wave interactions but our proof strategy differs fundamentally from that used by Israel and is an extension of the strategy outlined in our original Proc. R. Soc. A publication. Whether regularity singularities exist in more complicated shock wave solutions of the Einstein–Euler equations remains open. PMID:27547092

Land-use planning of Volyn region (Ukraine) using Geographic Information Systems (GIS) technologies

NASA Astrophysics Data System (ADS)

Strielko, Irina; Pereira, Paulo

2014-05-01

Land-use development planning is carried out in order to create a favourable environment for human life, sustainable socioeconomic and spatial development. Landscape planning is an important part of land-use development that aims to meet the fundamental principles of sustainable development. Geographic Information Systems (GIS) is a fundamental tool to make a better landscape planning at different territorial levels, providing data and maps to support decision making. The objective of this work is to create spatio-temporal, territorial and ecological model of development of Volyn region (Ukraine). It is based on existing spatial raster and vector data and includes the analysis of territory dynamics as the aspects responsible for it. A spatial analyst tool was used to zone the areas according to their environmental components and economic activity. This analysis is fundamental to define the basic parameters of sustainability of Volyn region. To carry out this analysis, we determined the demographic capacity of districts and the analysis of spatial parameters of land use. On the basis of the existing natural resources, we observed that there is a need of landscape protection and integration of more are natural areas in the Pan-European Ecological Network. Using GIS technologies to landscape planning in Volyn region, allowed us to identify, natural areas of interest, contribute to a better resource management and conflict resolution. Geographic Information Systems will help to formulate and implement landscape policies, reform the existing administrative system of Volyn region and contribute to a better sustainable development.

Atomistic basis for the plastic yield criterion of metallic glass.

PubMed

Schuh, Christopher A; Lund, Alan C

2003-07-01

Because of their disordered atomic structure, amorphous metals (termed metallic glasses) have fundamentally different deformation mechanisms compared with polycrystalline metals. These different mechanisms give metallic glasses high strength, but the extent to which they affect other macroscopic deformation properties is uncertain. For example, the nature of the plastic-yield criterion is a point of contention, with some studies reporting yield behaviour roughly in line with that of polycrystalline metals, and others indicating strong fundamental differences. In particular, it is unclear whether pressure- or normal stress-dependence needs to be included in the plastic-yield criterion of metallic glasses, and how such a dependence could arise from their disordered structure. In this work we provide an atomic-level explanation for pressure-dependent yield in amorphous metals, based on an elementary unit of deformation. This simple model compares favourably with new atomistic simulations of metallic glasses, as well as existing experimental data.

Detection principles of biological and chemical FET sensors.

PubMed

Kaisti, Matti

2017-12-15

The seminal importance of detecting ions and molecules for point-of-care tests has driven the search for more sensitive, specific, and robust sensors. Electronic detection holds promise for future miniaturized in-situ applications and can be integrated into existing electronic manufacturing processes and technology. The resulting small devices will be inherently well suited for multiplexed and parallel detection. In this review, different field-effect transistor (FET) structures and detection principles are discussed, including label-free and indirect detection mechanisms. The fundamental detection principle governing every potentiometric sensor is introduced, and different state-of-the-art FET sensor structures are reviewed. This is followed by an analysis of electrolyte interfaces and their influence on sensor operation. Finally, the fundamentals of different detection mechanisms are reviewed and some detection schemes are discussed. In the conclusion, current commercial efforts are briefly considered. Copyright © 2017 The Authors. Published by Elsevier B.V. All rights reserved.

Processing of Tense Morphology and Filler-Gap Dependencies by Chinese Second Language Speakers of English

ERIC Educational Resources Information Center

Dong, Zhiyin Renee

2014-01-01

There is an ongoing debate in the field of Second Language Acquisition concerning whether a fundamental difference exists between the native language (L1) and adult second language (L2) online processing of syntax and morpho-syntax. The Shallow Structure Hypothesis (SSH) (Clahsen and Felser, 2006a, b) states that L2 online parsing is qualitatively…

Mixed Criticality Scheduling for Industrial Wireless Sensor Networks

PubMed Central

Jin, Xi; Xia, Changqing; Xu, Huiting; Wang, Jintao; Zeng, Peng

2016-01-01

Wireless sensor networks (WSNs) have been widely used in industrial systems. Their real-time performance and reliability are fundamental to industrial production. Many works have studied the two aspects, but only focus on single criticality WSNs. Mixed criticality requirements exist in many advanced applications in which different data flows have different levels of importance (or criticality). In this paper, first, we propose a scheduling algorithm, which guarantees the real-time performance and reliability requirements of data flows with different levels of criticality. The algorithm supports centralized optimization and adaptive adjustment. It is able to improve both the scheduling performance and flexibility. Then, we provide the schedulability test through rigorous theoretical analysis. We conduct extensive simulations, and the results demonstrate that the proposed scheduling algorithm and analysis significantly outperform existing ones. PMID:27589741

Mastery of fundamental movement skills among children in New South Wales: prevalence and sociodemographic distribution.

PubMed

Okely, A D; Booth, M L

2004-09-01

Fundamental movement skills form the foundation for many of the specific motor skills employed in popular sports and leisure activities. Little data exist on the prevalence and socioeconomic distribution of fundamental movement skill mastery among young children in Australia. This study process-assessed performance on six fundamental movement skills in a randomly selected sample of students from Years 1 through 3 in the Sydney metropolitan area of New South Wales. The prevalence and sociodemographic distribution of mastery and near mastery for each skill and each skill component is reported for boys and girls in each school year. The findings revealed that the prevalence of mastery and near mastery of each of fundamental movement skill was generally low. Boys performed significantly better than girls in the run and in the four object-control skills (throw, catch, kick, and strike) whilst girls performed better than boys in the skip. There was no consistent association between prevalence of skill mastery and socio-economic status (SES), with only the kick and vertical jump for boys and catch, dodge, and vertical jump for girls differing across SES tertiles. Based on these results, we recommend that adequate curriculum time, resources, and professional development continue to be devoted to fundamental movement skills in NSW primary schools.

A new approach to harmonic elimination based on a real-time comparison method

NASA Astrophysics Data System (ADS)

Gourisetti, Sri Nikhil Gupta

Undesired harmonics are responsible for noise in a transmission channel, power loss in power electronics and in motor control. Selective Harmonic Elimination (SHE) is a well-known method used to eliminate or suppress the unwanted harmonics between the fundamental and the carrier frequency harmonic/component. But SHE bears the disadvantage of its incapability to use in real-time applications. A novel reference-carrier comparative method has been developed which can be used to generate an SPWM signal to apply in real-time systems. A modified carrier signal is designed and tested for different carrier frequencies based on the generated SPWM FFT. The carrier signal may change for different fundamental to carrier ratio that leads to solving the equations each time. An analysis to find all possible solutions for a particular carrier frequency and fundamental amplitude is performed and found. This proves that there is no one global maxima instead several local maximas exists for a particular condition set that makes this method less sensitive. Additionally, an attempt to find a universal solution that is valid for any carrier signal with predefined fundamental amplitude is performed. A uniform distribution Monte-Carlo sensitivity analysis is performed to measure the window i.e., best and worst possible solutions. The simulations are performed using MATLAB and are justified with experimental results.

On the fundamental properties of dynamically hot galaxies

NASA Astrophysics Data System (ADS)

Kritsuk, Alexei G.

1997-01-01

A two-component isothermal equilibrium model is applied to reproduce basic structural properties of dynamically hot stellar systems immersed in their massive dark haloes. The origin of the fundamental plane relation for giant ellipticals is naturally explained as a consequence of dynamical equilibrium in the context of the model. The existence of two galactic families displaying different behaviour in the luminosity-surface-brightness diagram is shown to be a result of a smooth transition from dwarfs, dominated by dark matter near the centre, to giants dominated by the luminous stellar component. The comparison of empirical scaling relations with model predictions suggests that probably a unique dissipative process was operating during the violent stage of development of stellar systems in the dark haloes, and the depth of the potential well controlled the observed luminosity of the resulting galaxies. The interpretation also provides some restrictions on the properties of dark haloes implied by the fundamental scaling laws.

The dominant mode of standing Alfven waves at the synchronous orbit

NASA Technical Reports Server (NTRS)

Cummins, W. D.; Countee, C.; Lyons, D.; Wiley, W., III

1975-01-01

Low-frequency oscillations of the earth's magnetic field recorded by a magnetometer on board ATS 1 have been examined for the 6-month interval between January and June 1968. Using evidence from OGO 5 and ATS 5 as well as the data from ATS 1, it is argued that the dominant mode at ATS 1 must be the fundamental rather than the second harmonic of a standing Alfven wave. It is concluded that these transverse oscillations are more accurately associated with magnetically disturbed days than with quiet days. From 14 instances when oscillations of distinctly different periods occurred during the same time interval at ATS 1, it is also concluded that higher harmonics can exist. The period ratio in seven of the 14 cases corresponds to the simultaneous occurrence of the second harmonic with the fundamental, and four other cases could be identified as the simultaneous occurrence of the fourth harmonic with the fundamental.

Niche tracking and rapid establishment of distributional equilibrium in the house sparrow show potential responsiveness of species to climate change.

PubMed

Monahan, William B; Tingley, Morgan W

2012-01-01

The ability of species to respond to novel future climates is determined in part by their physiological capacity to tolerate climate change and the degree to which they have reached and continue to maintain distributional equilibrium with the environment. While broad-scale correlative climatic measurements of a species' niche are often described as estimating the fundamental niche, it is unclear how well these occupied portions actually approximate the fundamental niche per se, versus the fundamental niche that exists in environmental space, and what fitness values bounding the niche are necessary to maintain distributional equilibrium. Here, we investigate these questions by comparing physiological and correlative estimates of the thermal niche in the introduced North American house sparrow (Passer domesticus). Our results indicate that occupied portions of the fundamental niche derived from temperature correlations closely approximate the centroid of the existing fundamental niche calculated on a fitness threshold of 50% population mortality. Using these niche measures, a 75-year time series analysis (1930-2004) further shows that: (i) existing fundamental and occupied niche centroids did not undergo directional change, (ii) interannual changes in the two niche centroids were correlated, (iii) temperatures in North America moved through niche space in a net centripetal fashion, and consequently, (iv) most areas throughout the range of the house sparrow tracked the existing fundamental niche centroid with respect to at least one temperature gradient. Following introduction to a new continent, the house sparrow rapidly tracked its thermal niche and established continent-wide distributional equilibrium with respect to major temperature gradients. These dynamics were mediated in large part by the species' broad thermal physiological tolerances, high dispersal potential, competitive advantage in human-dominated landscapes, and climatically induced changes to the realized environmental space. Such insights may be used to conceptualize mechanistic climatic niche models in birds and other taxa.

Fundamental period of Italian reinforced concrete buildings: comparison between numerical, experimental and Italian code simplified values

NASA Astrophysics Data System (ADS)

Ditommaso, Rocco; Carlo Ponzo, Felice; Auletta, Gianluca; Iacovino, Chiara; Nigro, Antonella

2015-04-01

Aim of this study is a comparison among the fundamental period of reinforced concrete buildings evaluated using the simplified approach proposed by the Italian Seismic code (NTC 2008), numerical models and real values retrieved from an experimental campaign performed on several buildings located in Basilicata region (Italy). With the intention of proposing simplified relationships to evaluate the fundamental period of reinforced concrete buildings, scientists and engineers performed several numerical and experimental campaigns, on different structures all around the world, to calibrate different kind of formulas. Most of formulas retrieved from both numerical and experimental analyses provides vibration periods smaller than those suggested by the Italian seismic code. However, it is well known that the fundamental period of a structure play a key role in the correct evaluation of the spectral acceleration for seismic static analyses. Generally, simplified approaches impose the use of safety factors greater than those related to in depth nonlinear analyses with the aim to cover possible unexpected uncertainties. Using the simplified formula proposed by the Italian seismic code the fundamental period is quite higher than fundamental periods experimentally evaluated on real structures, with the consequence that the spectral acceleration adopted in the seismic static analysis may be significantly different than real spectral acceleration. This approach could produces a decreasing in safety factors obtained using linear and nonlinear seismic static analyses. Finally, the authors suggest a possible update of the Italian seismic code formula for the simplified estimation of the fundamental period of vibration of existing RC buildings, taking into account both elastic and inelastic structural behaviour and the interaction between structural and non-structural elements. Acknowledgements This study was partially funded by the Italian Civil Protection Department within the project DPC-RELUIS 2014 - RS4 ''Seismic observatory of structures and health monitoring''. References R. Ditommaso, M. Vona, M. R. Gallipoli and M. Mucciarelli (2013). Evaluation and considerations about fundamental periods of damaged reinforced concrete buildings. Nat. Hazards Earth Syst. Sci., 13, 1903-1912, 2013. www.nat-hazards-earth-syst-sci.net/13/1903/2013. doi:10.5194/nhess-13-1903-2013

System-theoretic Interpretation of the Mode Sensing Hypothesis

DTIC Science & Technology

2014-08-01

estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the...6. AUTHOR(S) Prof. Rafal Zbikowski Prof. Graham Taylor 5d. PROJECT NUMBER 5d. TASK NUMBER 5e. WORK UNIT NUMBER 7. PERFORMING...insect flight control has more recently been modelled. The approach that we adopt here differs from previous, related work in several fundamental

Enhanced vasomotion of cerebral arterioles in spontaneously hypertensive rats

NASA Technical Reports Server (NTRS)

Lefer, D. J.; Lynch, C. D.; Lapinski, K. C.; Hutchins, P. M.

1990-01-01

Intrinsic rhythmic changes in the diameter of pial cerebral arterioles (30-70 microns) in anesthetized normotensive and hypertensive rats were assessed in vivo to determine if any significant differences exist between the two strains. All diameter measurements were analyzed using a traditional graphic analysis technique and a new frequency spectrum analysis technique known as the Prony Spectral Line Estimator. Graphic analysis of the data revealed that spontaneously hypertensive rats (SHR) possess a significantly greater fundamental frequency (5.57 +/- 0.28 cycles/min) of vasomotion compared to the control Wistar-Kyoto normotensive rats (WKY) (1.95 +/- 0.37 cycles/min). Furthermore, the SHR cerebral arterioles exhibited a significantly greater amplitude of vasomotion (10.07 +/- 0.70 microns) when compared to the WKY cerebral arterioles of the same diameter (8.10 +/- 0.70 microns). Diameter measurements processed with the Prony technique revealed that the fundamental frequency of vasomotion in SHR cerebral arterioles (6.14 +/- 0.39 cycles/min) was also significantly greater than that of the WKY cerebral arterioles (2.99 +/- 0.42 cycles/min). The mean amplitudes of vasomotion in the SHR and WKY strains obtained by the Prony analysis were found not to be statistically significant in contrast to the graphic analysis of the vasomotion amplitude of the arterioles. In addition, the Prony system was able to consistently uncover a very low frequency of vasomotion in both strains of rats that was typically less than 1 cycle/min and was not significantly different between the two strains. The amplitude of this slow frequency was also not significantly different between the two strains. The amplitude of the slow frequency of vasomotion (less than 1 cycle/min) was not different from the amplitude of the higher frequency (2-6 cycles/min) vasomotion by Prony or graphic analysis. These data suggest that a fundamental intrinsic defect exists in the spontaneously hypertensive rat that may contribute to the pathogenesis of hypertension in these animals.

Are sex differences in fundamental motor skills uniform throughout the entire preschool period?

PubMed

Kokštejn, Jakub; Musálek, Martin; Tufano, James J

2017-01-01

The aim of this study was to assess differences in fundamental motor skills (FMS) proficiency between boys and girls of each age group, independently, across the entire preschool period. Using the Movement Assessment Battery for Children-second edition, FMS proficiency was tested in 325 preschoolers (4.9 ± 1.1 y, range 3-6) using a cross-sectional design. Compared to boys of the same age, 3- and 4-year-old girls had greater total (p < .01), fine motor skill (p < .01), and balance scores (p < .05). There were no sex differences for total test or balance scores in 5- and 6-year-olds, but 6-year-old boys outperformed girls in aiming and catching (p < .001). These data not only agree with previous research in that sex differences in FMS proficiency exist in preschool children, but the data also show that differences may not be uniform throughout the whole preschool period when analyzing by age. To avoid under- or overestimating FMS proficiency and subsequently prescribing inaccurate motor intervention programs, FMS proficiency normative values should be age- and sex-specific throughout the entire preschool period.

Broadband pulsed difference frequency generation laser source centered 3326 nm based on ring fiber lasers

NASA Astrophysics Data System (ADS)

Chen, Guangwei; Li, Wenlei

2018-03-01

A broadband pulsed mid-infrared difference frequency generation (DFG) laser source based on MgO-doped congruent LiNbO3 bulk is experimentally demonstrated, which employs a homemade pulsed ytterbium-doped ring fiber laser and a continuous wave erbium-doped ring fiber laser to act as seed sources. The experimental results indicate that the perfect phase match crystal temperature is about 74.5∘C. The maximum spectrum bandwidth of idler is about 60 nm with suitable polarization states of fundamental lights. The central wavelength of idlers varies from 3293 nm to 3333 nm over the crystal temperature ranges of 70.4-76∘C. A jump of central wavelength exists around crystal temperature of 72∘C with variation of about 30 nm. The conversion efficiency of DFG can be tuned with the crystal temperature and polarization states of fundamental lights.

Reconsidering earthquake scaling

USGS Publications Warehouse

Gomberg, Joan S.; Wech, Aaron G.; Creager, Kenneth; Obara, K.; Agnew, Duncan

2016-01-01

The relationship (scaling) between scalar moment, M0, and duration, T, potentially provides key constraints on the physics governing fault slip. The prevailing interpretation of M0-T observations proposes different scaling for fast (earthquakes) and slow (mostly aseismic) slip populations and thus fundamentally different driving mechanisms. We show that a single model of slip events within bounded slip zones may explain nearly all fast and slow slip M0-T observations, and both slip populations have a change in scaling, where the slip area growth changes from 2-D when too small to sense the boundaries to 1-D when large enough to be bounded. We present new fast and slow slip M0-T observations that sample the change in scaling in each population, which are consistent with our interpretation. We suggest that a continuous but bimodal distribution of slip modes exists and M0-T observations alone may not imply a fundamental difference between fast and slow slip.

Absence of a fundamental acceleration scale in galaxies

NASA Astrophysics Data System (ADS)

Rodrigues, Davi C.; Marra, Valerio; del Popolo, Antonino; Davari, Zahra

2018-06-01

Dark matter is currently one of the main mysteries of the Universe. There is much strong indirect evidence that supports its existence, but there is yet no sign of a direct detection1-3. Moreover, at the scale of galaxies, there is tension between the theoretically expected dark matter distribution and its indirectly observed distribution4-7. Therefore, phenomena associated with dark matter have a chance of serving as a window towards new physics. The radial acceleration relation8,9 confirms that a non-trivial acceleration scale a0 can be found from the internal dynamics of several galaxies. The existence of such a scale is not obvious as far as the standard cosmological model is concerned10,11, and it has been interpreted as a possible sign of modified gravity12,13. Here, we consider 193 high-quality disk galaxies and, using Bayesian inference, show that the probability of existence of a fundamental acceleration is essentially 0: the null hypothesis is rejected at more than 10σ. We conclude that a0 is of emergent nature. In particular, the modified Newtonian dynamics theory14-17—a well-known alternative to dark matter based on the existence of a fundamental acceleration scale—or any other theory that behaves like it at galactic scales, is ruled out as a fundamental theory for galaxies at more than 10σ.

Do Racial and Gender Disparities Exist in Newer Glaucoma Treatments?

MedlinePlus

... 2019 Basic and Clinical Science Course, Section 02: Fundamentals and Principles of Ophthalmology 2018-2019 Basic and ... 2019 Basic and Clinical Science Course, Section 02: Fundamentals and Principles of Ophthalmology Print 2018-2019 Basic ...

Quantification of the level of crowdedness for pedestrian movements

NASA Astrophysics Data System (ADS)

Duives, Dorine C.; Daamen, Winnie; Hoogendoorn, Serge P.

2015-06-01

Within the realm of pedestrian research numerous measures have been proposed to estimate the level of crowdedness experienced by pedestrians. However, within the field of pedestrian traffic flow modelling there does not seem to be consensus on the question which of these measures performs best. This paper shows that the shape and scatter within the resulting fundamental diagrams differs a lot depending on the measure of crowdedness used. The main aim of the paper is to establish the advantages and disadvantages of the currently existing measures to quantify crowdedness in order to evaluate which measures provide both accurate and consistent results. The assessment is not only based on the theoretical differences, but also on the qualitative and quantitative differences between the resulting fundamental diagrams computed using the crowdedness measures on one and the same data set. The qualitative and quantitative functioning of the classical Grid-based measure is compared to with the X-T measure, an Exponentially Weighted Distance measure, and a Voronoi-Diagram measure. The consistency of relating these measures for crowdedness to the two macroscopic flow variables velocity and flow, the computational efficiency and the amount of scatter present within the fundamental diagrams produced by the implementation of the different measures are reviewed. It is found that the Voronoi-Diagram and X-T measure are the most efficient and consistent measures for crowdedness.

An integration of integrated information theory with fundamental physics

PubMed Central

Barrett, Adam B.

2014-01-01

To truly eliminate Cartesian ghosts from the science of consciousness, we must describe consciousness as an aspect of the physical. Integrated Information Theory states that consciousness arises from intrinsic information generated by dynamical systems; however existing formulations of this theory are not applicable to standard models of fundamental physical entities. Modern physics has shown that fields are fundamental entities, and in particular that the electromagnetic field is fundamental. Here I hypothesize that consciousness arises from information intrinsic to fundamental fields. This hypothesis unites fundamental physics with what we know empirically about the neuroscience underlying consciousness, and it bypasses the need to consider quantum effects. PMID:24550877

The Development of Fundamental Movement Skills by Children Aged Six to Nine

ERIC Educational Resources Information Center

Lin, Shu-Jung; Yang, Shu-Chu

2015-01-01

The main purpose of the present study is to elucidate any differences which may exist in the FMSs of children between the ages of six and nine. Purposive sampling was used to recruit a total of 485 participants (244 boys and 241 girls) in Chiayi City and Chiayi County. All of the participants were between the ages of six and nine and had no…

Stellar Evolution and Modelling Stars

NASA Astrophysics Data System (ADS)

Silva Aguirre, Víctor

In this chapter I give an overall description of the structure and evolution of stars of different masses, and review the main ingredients included in state-of-the-art calculations aiming at reproducing observational features. I give particular emphasis to processes where large uncertainties still exist as they have strong impact on stellar properties derived from large compilations of tracks and isochrones, and are therefore of fundamental importance in many fields of astrophysics.

Phenotypic responses to interspecies competition and commensalism in a naturally-derived microbial co-culture.

PubMed

Khan, Nymul; Maezato, Yukari; McClure, Ryan S; Brislawn, Colin J; Mobberley, Jennifer M; Isern, Nancy; Chrisler, William B; Markillie, Lye Meng; Barney, Brett M; Song, Hyun-Seob; Nelson, William C; Bernstein, Hans C

2018-01-10

The fundamental question of whether different microbial species will co-exist or compete in a given environment depends on context, composition and environmental constraints. Model microbial systems can yield some general principles related to this question. In this study we employed a naturally occurring co-culture composed of heterotrophic bacteria, Halomonas sp. HL-48 and Marinobacter sp. HL-58, to ask two fundamental scientific questions: 1) how do the phenotypes of two naturally co-existing species respond to partnership as compared to axenic growth? and 2) how do growth and molecular phenotypes of these species change with respect to competitive and commensal interactions? We hypothesized - and confirmed - that co-cultivation under glucose as the sole carbon source would result in competitive interactions. Similarly, when glucose was swapped with xylose, the interactions became commensal because Marinobacter HL-58 was supported by metabolites derived from Halomonas HL-48. Each species responded to partnership by changing both its growth and molecular phenotype as assayed via batch growth kinetics and global transcriptomics. These phenotypic responses depended on nutrient availability and so the environment ultimately controlled how they responded to each other. This simplified model community revealed that microbial interactions are context-specific and different environmental conditions dictate how interspecies partnerships will unfold.

Phenotypic responses to interspecies competition and commensalism in a naturally-derived microbial co-culture

DOE Office of Scientific and Technical Information (OSTI.GOV)

Khan, Nymul; Maezato, Yukari; McClure, Ryan S.

The fundamental question of whether different microbial species will co-exist or compete in a given environment depends on context, composition and environmental constraints. Model microbial systems can yield some general principles related to this question. In this study we employed a naturally occurring co-culture composed of heterotrophic bacteria, Halomonas sp. HL-48 and Marinobacter sp. HL-58, to ask two fundamental scientific questions: 1) how do the phenotypes of two naturally co-existing species respond to partnership as compared to axenic growth? and 2) how do growth and molecular phenotypes of these species change with respect to competitive and commensal interactions? We hypothesizedmore » – and confirmed – that co-cultivation under glucose as the sole carbon source would result in a competitive interactions. Similarly, when glucose was swapped with xylose, the interactions became commensal because Marinobacter HL-58 was supported by metabolites derived from Halomonas HL-48. Each species responded to partnership by changing both its growth and molecular phenotype as assayed via batch growth kinetics and global transcriptomics. These phenotypic responses depended nutrient availability and so the environment ultimately controlled how they responded to each other. This simplified model community revealed that microbial interactions are context-specific and different environmental conditions dictate how interspecies partnerships will unfold.« less

The dominant mode of standing Alfven waves at synchronous orbit

NASA Technical Reports Server (NTRS)

Cummings, W. D.; Countee, C.; Lyons, D.; Wiley, W., III

1975-01-01

Low-frequency oscillations of the earth's magnetic field recorded by the UCLA magnetometer on board ATS-1, have been examined for the six-month interval, January-June, 1968. The initial interpretation, that these oscillations represent the second harmonic of a standing Alfven wave, has been re-examined, and it is concluded that this hypothesis must be withdrawn. Using evidence from OGO-5 and ATS-5, as well as the data from ATS-1, it is argued that the dominant mode at the synchronous orbit must be the fundamental rather than the second harmonic. From 14 instances when the oscillations of distinctly different periods occurred during the same time interval at ATS-1 it is concluded that higher harmonics can exist. The period ratio in 7 of the 14 cases corresponds to the simultaneous occurrence of the second harmonic with the fundamental, and 4 other cases could be identified as the simultaneous occurrence of the fourth harmonic with the fundamental.

Applying and extending ISO/TC42 digital camera resolution standards to mobile imaging products

NASA Astrophysics Data System (ADS)

Williams, Don; Burns, Peter D.

2007-01-01

There are no fundamental differences between today's mobile telephone cameras and consumer digital still cameras that suggest many existing ISO imaging performance standards do not apply. To the extent that they have lenses, color filter arrays, detectors, apertures, image processing, and are hand held, there really are no operational or architectural differences. Despite this, there are currently differences in the levels of imaging performance. These are driven by physical and economic constraints, and image-capture conditions. Several ISO standards for resolution, well established for digital consumer digital cameras, require care when applied to the current generation of cell phone cameras. In particular, accommodation of optical flare, shading non-uniformity and distortion are recommended. We offer proposals for the application of existing ISO imaging resolution performance standards to mobile imaging products, and suggestions for extending performance standards to the characteristic behavior of camera phones.

Musical emotions: Functions, origins, evolution

NASA Astrophysics Data System (ADS)

Perlovsky, Leonid

2010-03-01

Theories of music origins and the role of musical emotions in the mind are reviewed. Most existing theories contradict each other, and cannot explain mechanisms or roles of musical emotions in workings of the mind, nor evolutionary reasons for music origins. Music seems to be an enigma. Nevertheless, a synthesis of cognitive science and mathematical models of the mind has been proposed describing a fundamental role of music in the functioning and evolution of the mind, consciousness, and cultures. The review considers ancient theories of music as well as contemporary theories advanced by leading authors in this field. It addresses one hypothesis that promises to unify the field and proposes a theory of musical origin based on a fundamental role of music in cognition and evolution of consciousness and culture. We consider a split in the vocalizations of proto-humans into two types: one less emotional and more concretely-semantic, evolving into language, and the other preserving emotional connections along with semantic ambiguity, evolving into music. The proposed hypothesis departs from other theories in considering specific mechanisms of the mind-brain, which required the evolution of music parallel with the evolution of cultures and languages. Arguments are reviewed that the evolution of language toward becoming the semantically powerful tool of today required emancipation from emotional encumbrances. The opposite, no less powerful mechanisms required a compensatory evolution of music toward more differentiated and refined emotionality. The need for refined music in the process of cultural evolution is grounded in fundamental mechanisms of the mind. This is why today's human mind and cultures cannot exist without today's music. The reviewed hypothesis gives a basis for future analysis of why different evolutionary paths of languages were paralleled by different evolutionary paths of music. Approaches toward experimental verification of this hypothesis in psychological and neuroimaging research are reviewed.

Measuring ocean coherence time with dual-baseline interferometry

NASA Technical Reports Server (NTRS)

Carande, Richard E.

1992-01-01

Using the Jet Propulsion Laboratory (JPL) Airborne Synthetic Aperture Radar (AIRSAR) interferometer, measurements of the ocean coherence time at L and C band can be made at high spatial resolution. Fundamental to this measurement is the ability to image the ocean interferometrically at two different time-lags, or baselines. By modifying the operating procedure of the existing two antenna interferometer, a technique was developed make these measurements. L band coherence times are measured and presented.

The model for Fundamentals of Endovascular Surgery (FEVS) successfully defines the competent endovascular surgeon.

PubMed

Duran, Cassidy; Estrada, Sean; O'Malley, Marcia; Sheahan, Malachi G; Shames, Murray L; Lee, Jason T; Bismuth, Jean

2015-12-01

Fundamental skills testing is now required for certification in general surgery. No model for assessing fundamental endovascular skills exists. Our objective was to develop a model that tests the fundamental endovascular skills and differentiates competent from noncompetent performance. The Fundamentals of Endovascular Surgery model was developed in silicon and virtual-reality versions. Twenty individuals (with a range of experience) performed four tasks on each model in three separate sessions. Tasks on the silicon model were performed under fluoroscopic guidance, and electromagnetic tracking captured motion metrics for catheter tip position. Image processing captured tool tip position and motion on the virtual model. Performance was evaluated using a global rating scale, blinded video assessment of error metrics, and catheter tip movement and position. Motion analysis was based on derivations of speed and position that define proficiency of movement (spectral arc length, duration of submovement, and number of submovements). Performance was significantly different between competent and noncompetent interventionalists for the three performance measures of motion metrics, error metrics, and global rating scale. The mean error metric score was 6.83 for noncompetent individuals and 2.51 for the competent group (P < .0001). Median global rating scores were 2.25 for the noncompetent group and 4.75 for the competent users (P < .0001). The Fundamentals of Endovascular Surgery model successfully differentiates competent and noncompetent performance of fundamental endovascular skills based on a series of objective performance measures. This model could serve as a platform for skills testing for all trainees. Copyright © 2015 Society for Vascular Surgery. Published by Elsevier Inc. All rights reserved.

Mathematical theory of exchange-driven growth

NASA Astrophysics Data System (ADS)

Esenturk, Emre

2018-07-01

Exchange-driven growth is a process in which pairs of clusters interact by exchanging single unit of mass at a time. The rate of exchange is given by an interaction kernel which depends on the masses of the two interacting clusters. In this paper we establish the fundamental mathematical properties of the mean field rate equations of this process for the first time. We find two different classes of behavior depending on whether is symmetric or not. For the non-symmetric case, we prove global existence and uniqueness of solutions for kernels satisfying . This result is optimal in the sense that we show for a large class of initial conditions and kernels satisfying the solutions cannot exist. On the other hand, for symmetric kernels, we prove global existence of solutions for ( while existence is lost for ( In the intermediate regime we can only show local existence. We conjecture that the intermediate regime exhibits finite-time gelation in accordance with the heuristic results obtained for particular kernels.

Breeds of risk-adjusted fundamentalist strategies in an order-driven market

NASA Astrophysics Data System (ADS)

LiCalzi, Marco; Pellizzari, Paolo

2006-01-01

This paper studies an order-driven stock market where agents have heterogeneous estimates of the fundamental value of the risky asset. The agents are budget-constrained and follow a value-based trading strategy which buys or sells depending on whether the price of the asset is below or above its risk-adjusted fundamental value. This environment generates returns that are remarkably leptokurtic and fat-tailed. By extending the study over a grid of different parameters for the fundamentalist trading strategy, we exhibit the existence of monotone relationships between the bid-ask spread demanded by the agents and several statistics of the returns. We conjecture that this effect, coupled with positive dependence of the risk premium on the volatility, generates positive feedbacks that might explain volatility bursts.

Some Effects of Compressibility on the Flow Through Fans and Turbines

NASA Technical Reports Server (NTRS)

Perl, W.; Epstein, H. T.

1946-01-01

The laws of conservation of mass, momentum, and energy are applied to the compressible flow through a two-dimensional cascade of airfoils. A fundamental relation between the ultimate upstream and downstream flow angles, the inlet Mach number, and the pressure ratio across the cascade is derived. Comparison with the corresponding relation for incompressible flow shows large differences. The fundamental relation reveals two ranges of flow angles and inlet Mach numbers, for which no ideal pressure ratio exists. One of these nonideal operating ranges is analogous to a similar type in incompressible flow. The other is characteristic only of compressible flow. The effect of variable axial-flow area is treated. Some implications of the basic conservation laws in the case of nonideal flow through cascades are discussed.

From High Intellectual Potential to Asperger Syndrome: Evidence for Differences and a Fundamental Overlap-A Systematic Review.

PubMed

Boschi, Aurélie; Planche, Pascale; Hemimou, Cherhazad; Demily, Caroline; Vaivre-Douret, Laurence

2016-01-01

Background: An increasing number of clinicians point to similar clinical features between some children with High Intellectual Potential (HIP or "Giftedness" = Total IQ > 2 SD ), and children with Autism Spectrum Disorder (ASD) without intellectual or language delay, formerly diagnosed with Asperger Syndrome. Some of these common features are social interaction impairments, special interests, and in some cases high-verbal abilities. The aim of this article is to determine whether these similarities exist at more fundamental levels, other than clinical, and to explore the literature in order to provide empirical support for an overlap between ASD and HIP. Method: First, comparative studies between ASD and HIP children were sought. Because of a lack of data, the respective characteristics of ASD and HIP subjects were explored by a cross-sectional review of different areas of research. Emphasis was placed on psychometric and cognitive evaluations, experimental and developmental assessments, and neurobiological research, following a "bottom-up" procedure. Results: This review highlights the existence of similarities in the neurocognitive, developmental and neurobiological domains between these profiles, which require further study. In addition, the conclusions of several studies show that there are differences between HIP children with a homogeneous Intellectual Quotient profile and children with a heterogeneous Intellectual Quotient profile. Conclusion: HIP seems to cover different developmental profiles, one of which might share features with ASD. A new line of investigation providing a possible starting-point for future research is proposed. Its implications, interesting from both clinical and research perspectives, are discussed.

From High Intellectual Potential to Asperger Syndrome: Evidence for Differences and a Fundamental Overlap—A Systematic Review

PubMed Central

Boschi, Aurélie; Planche, Pascale; Hemimou, Cherhazad; Demily, Caroline; Vaivre-Douret, Laurence

2016-01-01

Background: An increasing number of clinicians point to similar clinical features between some children with High Intellectual Potential (HIP or “Giftedness” = Total IQ > 2 SD), and children with Autism Spectrum Disorder (ASD) without intellectual or language delay, formerly diagnosed with Asperger Syndrome. Some of these common features are social interaction impairments, special interests, and in some cases high-verbal abilities. The aim of this article is to determine whether these similarities exist at more fundamental levels, other than clinical, and to explore the literature in order to provide empirical support for an overlap between ASD and HIP. Method: First, comparative studies between ASD and HIP children were sought. Because of a lack of data, the respective characteristics of ASD and HIP subjects were explored by a cross-sectional review of different areas of research. Emphasis was placed on psychometric and cognitive evaluations, experimental and developmental assessments, and neurobiological research, following a “bottom-up” procedure. Results: This review highlights the existence of similarities in the neurocognitive, developmental and neurobiological domains between these profiles, which require further study. In addition, the conclusions of several studies show that there are differences between HIP children with a homogeneous Intellectual Quotient profile and children with a heterogeneous Intellectual Quotient profile. Conclusion: HIP seems to cover different developmental profiles, one of which might share features with ASD. A new line of investigation providing a possible starting-point for future research is proposed. Its implications, interesting from both clinical and research perspectives, are discussed. PMID:27812341

Are sex differences in fundamental motor skills uniform throughout the entire preschool period?

PubMed Central

2017-01-01

The aim of this study was to assess differences in fundamental motor skills (FMS) proficiency between boys and girls of each age group, independently, across the entire preschool period. Using the Movement Assessment Battery for Children–second edition, FMS proficiency was tested in 325 preschoolers (4.9 ± 1.1 y, range 3–6) using a cross-sectional design. Compared to boys of the same age, 3- and 4-year-old girls had greater total (p < .01), fine motor skill (p < .01), and balance scores (p < .05). There were no sex differences for total test or balance scores in 5- and 6-year-olds, but 6-year-old boys outperformed girls in aiming and catching (p < .001). These data not only agree with previous research in that sex differences in FMS proficiency exist in preschool children, but the data also show that differences may not be uniform throughout the whole preschool period when analyzing by age. To avoid under- or overestimating FMS proficiency and subsequently prescribing inaccurate motor intervention programs, FMS proficiency normative values should be age- and sex-specific throughout the entire preschool period. PMID:28448557

Brains, language and the argumentative mind in Western and Eastern societies. The fertile differences between Western-Eastern argumentative traditions.

PubMed

Vallverdú, Jordi

2017-12-01

The philosophical differences between Western and Eastern philosophy not only derive from general cultural ideas about reality, but as Nisbet writes (2003), are also methodological, ontological, and cognitively driven. Thus, we can see that strategies of thought and theory-generation are constrained and enabled by conceptual levels, and that the existence of differences and within these levels may be pragmatically combined in fruitful ways. At this point, I remark that there is not a single way to connect biology and culture, but at least we need to admit that brains allow the existence of minds and that these create languages, which also organize the world symbolically following a long set of (sometimes interconnected) heuristics. Throughout the paper we will see how fundamental, geographically located cultural perspectives have affected reasoning strategies and discourses, determining the main Western and Eastern Traditions. At the same time, we can conclude that different traditional perspectives allow more diversity for knowledge acquisition. Copyright © 2017 Elsevier Ltd. All rights reserved.

[Further challenges in collaboration and cross-specialization work in psychiatric services].

PubMed

Sakano, Yuji; Nakamura, Touru; Nakajima, Kimihiro

2011-01-01

Using a case illustrating cognitive behavioral treatment for a patient with obsessive-compulsive disorder, clinical tips and challenges are described in the context of collaboration between multiple health professionals from different backgrounds in a psychiatric hospital. Furthermore, after reviewing the current status of education and training issues related to collaboration, and introducing the fundamental concept of cross-specialization work, existing tasks and future challenges involved in the education and training of multiple health professions are discussed.

Driving CZTS to the SQ Limit: Solving the Open Circuit Voltage Problem

DOE Office of Scientific and Technical Information (OSTI.GOV)

Haight, Richard A.; McCandless, Brian E.; Kummel, Andrew C.

2016-12-15

A key objective of this 3 year research effort was to reduce the open circuit voltage (Voc) deficit, defined as the difference between the absorber band gap and the measured Voc to below 475mV from values at the beginning of this work of 630-730mV. To achieve this reduction, along with the attendant goals of higher Voc and efficiency, detailed studies into the fundamental understanding of existing limitations were undertaken.

Factory approach can streamline patient accounting.

PubMed

Rands, J; Muench, M

1991-08-01

Although they may seem fundamentally different, similarities exist between operations of factories and healthcare organizations' business offices. As a result, a patient accounting approach based on manufacturing firms' management techniques may help smooth healthcare business processes. Receivables performance management incorporates the Japanese techniques of "just-in-time" and total quality management to reduce unbilled accounts and information backlog and accelerate payment. A preliminary diagnostic assessment of a patient accounting process helps identify bottlenecks and set priorities for work flow.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stoynov, Y.

Functionally graded materials (FGM) are extensively used in modern industry. They are composite materials with continuously varying properties in one or more special dimensions, according to the specific purpose. In view of the wide range of applications of FGM, stress analysis is important for their structural integrity and reliable service life. In this study we will consider functionally graded magneto-electro-elastic materials with one or more cracks subjected to SH waves. We assume that the material properties vary in one and the same way, described by an inhomogeneity function. The boundary value problem is reduced to a system of integro-differential equationsmore » based on the existence of fundamental solutions. Different inhomogeneity classes are used to obtain a wave equation with constant coefficients. Radon transform is applied to derive the fundamental solution in a closed form. Program code in FORTRAN 77 is developed and validated using available examples from literature. Simulations show the dependence of stress field concentration near the crack tips on the frequency of the applied time-harmonic load for different types of material inhomogeneity.« less

On homogeneous second order linear general quantum difference equations.

PubMed

Faried, Nashat; Shehata, Enas M; El Zafarani, Rasha M

2017-01-01

In this paper, we prove the existence and uniqueness of solutions of the β -Cauchy problem of second order β -difference equations [Formula: see text] [Formula: see text], in a neighborhood of the unique fixed point [Formula: see text] of the strictly increasing continuous function β , defined on an interval [Formula: see text]. These equations are based on the general quantum difference operator [Formula: see text], which is defined by [Formula: see text], [Formula: see text]. We also construct a fundamental set of solutions for the second order linear homogeneous β -difference equations when the coefficients are constants and study the different cases of the roots of their characteristic equations. Finally, we drive the Euler-Cauchy β -difference equation.

The difference between “equivalent” and “not different”

DOE PAGES

Anderson-Cook, Christine M.; Borror, Connie M.

2015-10-27

Often, experimenters wish to establish that populations of units can be considered equivalent to each other, in order to leverage improved knowledge about one population for characterizing the new population, or to establish the comparability of items. Equivalence tests have existed for many years, but their use in industry seems to have been largely restricted to biomedical applications, such as for assessing the equivalence of two drugs or protocols. We present the fundamentals of equivalence tests, compare them to traditional two-sample and ANOVA tests that are better suited to establishing differences in populations, and propose the use of a graphicalmore » summary to compare p-values across different thresholds of practically important differences.« less

Fundamental science behind today's important medicines.

PubMed

Spector, Jonathan M; Harrison, Rosemary S; Fishman, Mark C

2018-04-25

Today's most transformative medicines exist because of fundamental discoveries that were made without regard to practical outcome and with their relevance to therapeutics only appearing decades later. Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.

Quantitative descriptions of generalized arousal, an elementary function of the vertebrate brain

PubMed Central

Quinkert, Amy Wells; Vimal, Vivek; Weil, Zachary M.; Reeke, George N.; Schiff, Nicholas D.; Banavar, Jayanth R.; Pfaff, Donald W.

2011-01-01

We review a concept of the most primitive, fundamental function of the vertebrate CNS, generalized arousal (GA). Three independent lines of evidence indicate the existence of GA: statistical, genetic, and mechanistic. Here we ask, is this concept amenable to quantitative analysis? Answering in the affirmative, four quantitative approaches have proven useful: (i) factor analysis, (ii) information theory, (iii) deterministic chaos, and (iv) application of a Gaussian equation. It strikes us that, to date, not just one but at least four different quantitative approaches seem necessary for describing different aspects of scientific work on GA. PMID:21555568

Pair-bonded humans conform to sexual stereotypes in web-based advertisements for extra-marital partners.

PubMed

Kelley, Trish C; Hare, James F

2010-10-20

Partners advertisements provide advertisers with access to a large pool of prospective mates, and have proven useful in documenting sex differences in human mating preferences. We coded data from an Internet site (AshleyMadison.com) catering to advertisers engaged in existing pair-bonded relationships. While we predicted that pair-bonding may liberate advertisers from conforming to sexual stereotypes of male promiscuity and female choosiness, our results are uniformly consistent with those stereotypes. Our findings thus provide further evidence that human mating behavior is highly constrained by fundamental biological differences between males and females.

Several foundational and information theoretic implications of Bell’s theorem

NASA Astrophysics Data System (ADS)

Kar, Guruprasad; Banik, Manik

2016-08-01

In 1935, Albert Einstein and two colleagues, Boris Podolsky and Nathan Rosen (EPR) developed a thought experiment to demonstrate what they felt was a lack of completeness in quantum mechanics (QM). EPR also postulated the existence of more fundamental theory where physical reality of any system would be completely described by the variables/states of that fundamental theory. This variable is commonly called hidden variable and the theory is called hidden variable theory (HVT). In 1964, John Bell proposed an empirically verifiable criterion to test for the existence of these HVTs. He derived an inequality, which must be satisfied by any theory that fulfill the conditions of locality and reality. He also showed that QM, as it violates this inequality, is incompatible with any local-realistic theory. Later it has been shown that Bell’s inequality (BI) can be derived from different set of assumptions and it also find applications in useful information theoretic protocols. In this review, we will discuss various foundational as well as information theoretic implications of BI. We will also discuss about some restricted nonlocal feature of quantum nonlocality and elaborate the role of Uncertainty principle and Complementarity principle in explaining this feature.

On the state of crystallography at the dawn of the electron microscopy revolution.

PubMed

Higgins, Matthew K; Lea, Susan M

2017-10-01

While protein crystallography has, for many years, been the most used method for structural analysis of macromolecular complexes, remarkable recent advances in high-resolution electron cryo-microscopy led to suggestions that 'the revolution will not be crystallised'. Here we highlight the current success rate, speed and ease of modern crystallographic structure determination and some recent triumphs of both 'classical' crystallography and the use of X-ray free electron lasers. We also outline fundamental differences between structure determination using X-ray crystallography and electron microscopy. We suggest that crystallography will continue to co-exist with electron microscopy as part of an integrated array of methods, allowing structural biologists to focus on fundamental biological questions rather than being constrained by the methods available. Copyright © 2017 The Authors. Published by Elsevier Ltd.. All rights reserved.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bradonjic, Milan; Hagberg, Aric; Hengartner, Nick

We analyze component evolution in general random intersection graphs (RIGs) and give conditions on existence and uniqueness of the giant component. Our techniques generalize the existing methods for analysis on component evolution in RIGs. That is, we analyze survival and extinction properties of a dependent, inhomogeneous Galton-Watson branching process on general RIGs. Our analysis relies on bounding the branching processes and inherits the fundamental concepts from the study on component evolution in Erdos-Renyi graphs. The main challenge becomes from the underlying structure of RIGs, when the number of offsprings follows a binomial distribution with a different number of nodes andmore » different rate at each step during the evolution. RIGs can be interpreted as a model for large randomly formed non-metric data sets. Besides the mathematical analysis on component evolution, which we provide in this work, we perceive RIGs as an important random structure which has already found applications in social networks, epidemic networks, blog readership, or wireless sensor networks.« less

Particles, Cutoffs and Inequivalent Representations

NASA Astrophysics Data System (ADS)

Egg, Matthias; Lam, Vincent; Oldofredi, Andrea

2017-03-01

We critically review the recent debate between Doreen Fraser and David Wallace on the interpretation of quantum field theory, with the aim of identifying where the core of the disagreement lies. We show that, despite appearances, their conflict does not concern the existence of particles or the occurrence of unitarily inequivalent representations. Instead, the dispute ultimately turns on the very definition of what a quantum field theory is. We further illustrate the fundamental differences between the two approaches by comparing them both to the Bohmian program in quantum field theory.

Fracture of Colvin-Galloway-Future band in a patient with mitral valve annuloplasty.

PubMed

Bauer, S; Rosendahl, U; Pietrowski, D; Ennker, J

2006-08-01

Annuloplasty with various annuloplasty ring systems is a fundamental part of mitral valve repair and has been frequently performed since its introduction by Carpentier in 1969. Due to the different advantages or disadvantages of each system, some controversies exist regarding the best type of ring annuloplasty support. Here we describe, for the first time, the case of a female patient in which a fracture of a semi-rigid open annuloplasty ring occurred, leading to annular deformation and mitral regurgitation.

CPTED 101: Crime Prevention through Environmental Design--The Fundamentals for Schools

ERIC Educational Resources Information Center

Schneider, Tod

2010-01-01

Crime Prevention through Environmental Design (CPTED) 101 applies to both new and existing schools and is built on three simple concepts: natural surveillance, natural access control, and territoriality. If a school's layout seems unsafe, adopting a few CPTED fundamentals may help make it significantly safer. This paper offers some tips for making…

Fundamental monogamy relation between contextuality and nonlocality.

PubMed

Kurzyński, Paweł; Cabello, Adán; Kaszlikowski, Dagomir

2014-03-14

We show that the no-disturbance principle imposes a tradeoff between locally contextual correlations violating the Klyachko-Can-Biniciogˇlu-Shumovski inequality and spatially separated correlations violating the Clauser-Horne-Shimony-Holt inequality. The violation of one inequality forbids the violation of the other. We also obtain the corresponding monogamy relation imposed by quantum theory for a qutrit-qubit system. Our results show the existence of fundamental monogamy relations between contextuality and nonlocality that suggest that entanglement might be a particular form of a more fundamental resource.

Predicting missing links via correlation between nodes

NASA Astrophysics Data System (ADS)

Liao, Hao; Zeng, An; Zhang, Yi-Cheng

2015-10-01

As a fundamental problem in many different fields, link prediction aims to estimate the likelihood of an existing link between two nodes based on the observed information. Since this problem is related to many applications ranging from uncovering missing data to predicting the evolution of networks, link prediction has been intensively investigated recently and many methods have been proposed so far. The essential challenge of link prediction is to estimate the similarity between nodes. Most of the existing methods are based on the common neighbor index and its variants. In this paper, we propose to calculate the similarity between nodes by the Pearson correlation coefficient. This method is found to be very effective when applied to calculate similarity based on high order paths. We finally fuse the correlation-based method with the resource allocation method, and find that the combined method can substantially outperform the existing methods, especially in sparse networks.

Analogs of microgravity: head-down tilt and water immersion.

PubMed

Watenpaugh, Donald E

2016-04-15

This article briefly reviews the fidelity of ground-based methods used to simulate human existence in weightlessness (spaceflight). These methods include horizontal bed rest (BR), head-down tilt bed rest (HDT), head-out water immersion (WI), and head-out dry immersion (DI; immersion with an impermeable elastic cloth barrier between subject and water). Among these, HDT has become by far the most commonly used method, especially for longer studies. DI is less common but well accepted for long-duration studies. Very few studies exist that attempt to validate a specific simulation mode against actual microgravity. Many fundamental physical, and thus physiological, differences exist between microgravity and our methods to simulate it, and between the different methods. Also, although weightlessness is the salient feature of spaceflight, several ancillary factors of space travel complicate Earth-based simulation. In spite of these discrepancies and complications, the analogs duplicate many responses to 0 G reasonably well. As we learn more about responses to microgravity and spaceflight, investigators will continue to fine-tune simulation methods to optimize accuracy and applicability. Copyright © 2016 the American Physiological Society.

Non-Asbestos Insulation Testing Using a Plasma Torch

NASA Technical Reports Server (NTRS)

Morgan, R. E.; Prince, A. S.; Selvidge, S. A.; Phelps, J.; Martin, C. L.; Lawrence, T. W.

2000-01-01

Insulation obsolescence issues are a major concern for the Reusable Solid Rocket Motor (RSRM). As old sources of raw materials disappear, new sources must be found and qualified. No simple, inexpensive test presently exists for predicting the erosion performance of a candidate insulation in the full-scale motor, Large motor tests cost million of dollars and therefore can only be used on a few very select candidates. There is a need for a simple, low cost method of screening insulation performance that can simulate some of the different erosion environments found in the RSRM. This paper describes a series of erosion tests on two different non-asbestos insulation formulations, a KEVLAR(registered) fiber-filled and a carbon fiber-filled insulation containing Ethylene-Propylene-Diene Monomer (EPDM) rubber as the binder. The test instrument was a plasma torch device. The two main variables investigated were heat flux and alumina particle impingement concentration. Statistical analysis revealed that the two different formulations had very different responses to the main variable. The results of this work indicate that there may be fundamental differences in how these insulation formulations perform in the motor operating environment. The plasma torch appears to offer a low-cost means of obtaining a fundamental understanding of insulation response to critical factors in a series of statistically designed experiments.

Environmental Assessment for Selection and Operation of the Proposed Field Research Centers for the Natural and Accelerated Bioremediation Research (NABIR) Program

DOE Office of Scientific and Technical Information (OSTI.GOV)

N /A

2000-04-18

The US Department of Energy (DOE) Office of Biological and Environmental Research (OBER), within the Office of Science (SC), proposes to add a Field Research Center (FRC) component to the existing Natural and Accelerated Bioremediation Research (NABIR) Program. The NABIR Program is a ten-year fundamental research program designed to increase the understanding of fundamental biogeochemical processes that would allow the use of bioremediation approaches for cleaning up DOE's contaminated legacy waste sites. An FRC would be integrated with the existing and future laboratory and field research and would provide a means of examining the fundamental biogeochemical processes that influence bioremediationmore » under controlled small-scale field conditions. The NABIR Program would continue to perform fundamental research that might lead to promising bioremediation technologies that could be demonstrated by other means in the future. For over 50 years, DOE and its predecessor agencies have been responsible for the research, design, and production of nuclear weapons, as well as other energy-related research and development efforts. DOE's weapons production and research activities generated hazardous, mixed, and radioactive waste products. Past disposal practices have led to the contamination of soils, sediments, and groundwater with complex and exotic mixtures of compounds. This contamination and its associated costs and risks represents a major concern to DOE and the public. The high costs, long duration, and technical challenges associated with remediating the subsurface contamination at DOE sites present a significant need for fundamental research in the biological, chemical, and physical sciences that will contribute to new and cost-effective solutions. One possible low-cost approach for remediating the subsurface contamination of DOE sites is through the use of a technology known as bioremediation. Bioremediation has been defined as the use of microorganisms to biodegrade or biotransform hazardous organic contaminants to environmentally safe levels in soils, subsurface materials, water, sludges, and residues.. While bioremediation technology is promising, DOE managers and non-DOE scientists have recognized that the fundamental scientific information needed to develop effective bioremediation technologies for cleanup of the legacy waste sites is lacking in many cases. DOE believes that field-based research is needed to realize the full potential of bioremediation. The Department of Energy faces a unique set of challenges associated with cleaning up waste at its former weapons production and research sites. These sites contain complex mixtures of contaminants in the subsurface, including radioactive compounds. In many cases, the fundamental field-based scientific information needed to develop safe and effective remediation and cleanup technologies is lacking. DOE needs fundamental research on the use of microorganisms and their products to assist DOE in the decontamination and cleanup of its legacy waste sites. The existing NABIR program to-date has focused on fundamental scientific research in the laboratory. Because subsurface hydrologic and geologic conditions at contaminated DOE sites cannot easily be duplicated in a laboratory, however, the DOE needs a field component to permit existing and future laboratory research results to be field-tested on a small scale in a controlled outdoor setting. Such field-testing needs to be conducted under actual legacy waste field conditions representative of those that DOE is most in need of remediating. Ideally, these field conditions should be as representative as practicable of the types of subsurface contamination conditions that resulted from legacy wastes from the nuclear weapons program activities. They should also be representative of the types of hydrologic and geologic conditions that exist across the DOE complex.« less

22 CFR 711.150 - Program accessibility: Existing facilities.

Code of Federal Regulations, 2010 CFR

2010-04-01

....150 Section 711.150 Foreign Relations OVERSEAS PRIVATE INVESTMENT CORPORATION ADMINISTRATIVE... THE OVERSEAS PRIVATE INVESTMENT CORPORATION § 711.150 Program accessibility: Existing facilities. (a... result in a fundamental alteration in the nature of a program or activity or in undue financial and...

Revisiting negative selection algorithms.

PubMed

Ji, Zhou; Dasgupta, Dipankar

2007-01-01

This paper reviews the progress of negative selection algorithms, an anomaly/change detection approach in Artificial Immune Systems (AIS). Following its initial model, we try to identify the fundamental characteristics of this family of algorithms and summarize their diversities. There exist various elements in this method, including data representation, coverage estimate, affinity measure, and matching rules, which are discussed for different variations. The various negative selection algorithms are categorized by different criteria as well. The relationship and possible combinations with other AIS or other machine learning methods are discussed. Prospective development and applicability of negative selection algorithms and their influence on related areas are then speculated based on the discussion.

Galaxy And Mass Assembly (GAMA): a deeper view of the mass, metallicity and SFR relationships

NASA Astrophysics Data System (ADS)

Lara-López, M. A.; Hopkins, A. M.; López-Sánchez, A. R.; Brough, S.; Gunawardhana, M. L. P.; Colless, M.; Robotham, A. S. G.; Bauer, A. E.; Bland-Hawthorn, J.; Cluver, M.; Driver, S.; Foster, C.; Kelvin, L. S.; Liske, J.; Loveday, J.; Owers, M. S.; Ponman, T. J.; Sharp, R. G.; Steele, O.; Taylor, E. N.; Thomas, D.

2013-09-01

A full appreciation of the role played by gas metallicity (Z), star formation rate (SFR) and stellar mass (M*) is fundamental to understanding how galaxies form and evolve. The connections between these three parameters at different redshifts significantly affect galaxy evolution, and thus provide important constraints for galaxy evolution models. Using data from the Sloan Digital Sky Survey-Data Release 7 (SDSS-DR7) and the Galaxy and Mass Assembly (GAMA) surveys, we study the relationships and dependences between SFR, Z and M*, as well as the Fundamental Plane for star-forming galaxies. We combine both surveys using volume-limited samples up to a redshift of z ≈ 0.36. The GAMA and SDSS surveys complement each other when analysing the relationships between SFR, M* and Z. We present evidence for SFR and metallicity evolution to z ˜ 0.2. We study the dependences between SFR, M*, Z and specific SFR (SSFR) on the M*-Z, M*-SFR, M*-SSFR, Z-SFR and Z-SSFR relations, finding strong correlations between all. Based on those dependences, we propose a simple model that allows us to explain the different behaviour observed between low- and high-mass galaxies. Finally, our analysis allows us to confirm the existence of a Fundamental Plane, for which M* = f(Z, SFR) in star-forming galaxies.

Liquid metal enabled pump

PubMed Central

Tang, Shi-Yang; Khoshmanesh, Khashayar; Sivan, Vijay; Petersen, Phred; O’Mullane, Anthony P.; Abbott, Derek; Mitchell, Arnan; Kalantar-zadeh, Kourosh

2014-01-01

Small-scale pumps will be the heartbeat of many future micro/nanoscale platforms. However, the integration of small-scale pumps is presently hampered by limited flow rate with respect to the input power, and their rather complicated fabrication processes. These issues arise as many conventional pumping effects require intricate moving elements. Here, we demonstrate a system that we call the liquid metal enabled pump, for driving a range of liquids without mechanical moving parts, upon the application of modest electric field. This pump incorporates a droplet of liquid metal, which induces liquid flow at high flow rates, yet with exceptionally low power consumption by electrowetting/deelectrowetting at the metal surface. We present theory explaining this pumping mechanism and show that the operation is fundamentally different from other existing pumps. The presented liquid metal enabled pump is both efficient and simple, and thus has the potential to fundamentally advance the field of microfluidics. PMID:24550485

Pulse generation scheme for flying electromagnetic doughnuts

NASA Astrophysics Data System (ADS)

Papasimakis, Nikitas; Raybould, Tim; Fedotov, Vassili A.; Tsai, Din Ping; Youngs, Ian; Zheludev, Nikolay I.

2018-05-01

Transverse electromagnetic plane waves are fundamental solutions of Maxwells equations. It is less known that a radically different type of solutions has been described theoretically, but has never been realized experimentally, that exist only in the form of short bursts of electromagnetic energy propagating in free space at the speed of light. They are distinguished from transverse waves by a doughnutlike configuration of electric and magnetic fields with a strong field component along the propagation direction. Here, we demonstrate numerically that such flying doughnuts can be generated from conventional pulses using a singular metamaterial converter designed to manipulate both the spatial and spectral structure of the input pulse. The ability to generate flying doughnuts is of fundamental interest, as they shall interact with matter in unique ways, including nontrivial field transformations upon reflection from interfaces and the excitation of toroidal response and anapole modes in matter, hence offering opportunities for telecommunications, sensing, and spectroscopy.

Realistic noise-tolerant randomness amplification using finite number of devices.

PubMed

Brandão, Fernando G S L; Ramanathan, Ravishankar; Grudka, Andrzej; Horodecki, Karol; Horodecki, Michał; Horodecki, Paweł; Szarek, Tomasz; Wojewódka, Hanna

2016-04-21

Randomness is a fundamental concept, with implications from security of modern data systems, to fundamental laws of nature and even the philosophy of science. Randomness is called certified if it describes events that cannot be pre-determined by an external adversary. It is known that weak certified randomness can be amplified to nearly ideal randomness using quantum-mechanical systems. However, so far, it was unclear whether randomness amplification is a realistic task, as the existing proposals either do not tolerate noise or require an unbounded number of different devices. Here we provide an error-tolerant protocol using a finite number of devices for amplifying arbitrary weak randomness into nearly perfect random bits, which are secure against a no-signalling adversary. The correctness of the protocol is assessed by violating a Bell inequality, with the degree of violation determining the noise tolerance threshold. An experimental realization of the protocol is within reach of current technology.

Realistic noise-tolerant randomness amplification using finite number of devices

NASA Astrophysics Data System (ADS)

Brandão, Fernando G. S. L.; Ramanathan, Ravishankar; Grudka, Andrzej; Horodecki, Karol; Horodecki, Michał; Horodecki, Paweł; Szarek, Tomasz; Wojewódka, Hanna

2016-04-01

Randomness is a fundamental concept, with implications from security of modern data systems, to fundamental laws of nature and even the philosophy of science. Randomness is called certified if it describes events that cannot be pre-determined by an external adversary. It is known that weak certified randomness can be amplified to nearly ideal randomness using quantum-mechanical systems. However, so far, it was unclear whether randomness amplification is a realistic task, as the existing proposals either do not tolerate noise or require an unbounded number of different devices. Here we provide an error-tolerant protocol using a finite number of devices for amplifying arbitrary weak randomness into nearly perfect random bits, which are secure against a no-signalling adversary. The correctness of the protocol is assessed by violating a Bell inequality, with the degree of violation determining the noise tolerance threshold. An experimental realization of the protocol is within reach of current technology.

Correlation techniques to determine model form in robust nonlinear system realization/identification

NASA Technical Reports Server (NTRS)

Stry, Greselda I.; Mook, D. Joseph

1991-01-01

The fundamental challenge in identification of nonlinear dynamic systems is determining the appropriate form of the model. A robust technique is presented which essentially eliminates this problem for many applications. The technique is based on the Minimum Model Error (MME) optimal estimation approach. A detailed literature review is included in which fundamental differences between the current approach and previous work is described. The most significant feature is the ability to identify nonlinear dynamic systems without prior assumption regarding the form of the nonlinearities, in contrast to existing nonlinear identification approaches which usually require detailed assumptions of the nonlinearities. Model form is determined via statistical correlation of the MME optimal state estimates with the MME optimal model error estimates. The example illustrations indicate that the method is robust with respect to prior ignorance of the model, and with respect to measurement noise, measurement frequency, and measurement record length.

Experimental determination of the x-ray atomic fundamental parameters of nickel

NASA Astrophysics Data System (ADS)

Ménesguen, Y.; Lépy, M.-C.; Hönicke, P.; Müller, M.; Unterumsberger, R.; Beckhoff, B.; Hoszowska, J.; Dousse, J.-Cl; Błachucki, W.; Ito, Y.; Yamashita, M.; Fukushima, S.

2018-02-01

The x-ray atomic properties of nickel (Ni) were investigated in a unique approach combining different experimental techniques to obtain new, useful and reliable values of atomic fundamental parameters for x-ray spectrometric purposes and for comparison with theoretical predictions. We determined the mass attenuation coefficients in an energy range covering the L- and K-absorption edges, the K-shell fluorescence yield and the Kβ/Kα and Kβ1, 3/Kα1, 2 transition probability ratios. The obtained line profiles and linewidths of the Kα and Kβ transitions in Ni can be considered as the contribution of the satellite lines arising from the [KM] shake processes suggested by Deutsch et al (1995 Phys. Rev. A 51 283) and Ito et al (2016 Phys. Rev. A 94 042506). Comparison of the new data with several databases showed good agreement, but also discrepancies were found with existing tabulated values.

Realistic noise-tolerant randomness amplification using finite number of devices

PubMed Central

Brandão, Fernando G. S. L.; Ramanathan, Ravishankar; Grudka, Andrzej; Horodecki, Karol; Horodecki, Michał; Horodecki, Paweł; Szarek, Tomasz; Wojewódka, Hanna

2016-01-01

Randomness is a fundamental concept, with implications from security of modern data systems, to fundamental laws of nature and even the philosophy of science. Randomness is called certified if it describes events that cannot be pre-determined by an external adversary. It is known that weak certified randomness can be amplified to nearly ideal randomness using quantum-mechanical systems. However, so far, it was unclear whether randomness amplification is a realistic task, as the existing proposals either do not tolerate noise or require an unbounded number of different devices. Here we provide an error-tolerant protocol using a finite number of devices for amplifying arbitrary weak randomness into nearly perfect random bits, which are secure against a no-signalling adversary. The correctness of the protocol is assessed by violating a Bell inequality, with the degree of violation determining the noise tolerance threshold. An experimental realization of the protocol is within reach of current technology. PMID:27098302

Network Motif Basis of Threshold Responses

EPA Science Inventory

There has been a long-running debate over the existence of thresholds for adverse effects. The difficulty stems from two fundamental challenges: (i) statistical analysis by itself cannot prove the existence of a threshold, i.e., a dose below which there is no effect; and (ii) the...

5 CFR 1636.150 - Program accessibility: Existing facilities.

Code of Federal Regulations, 2010 CFR

2010-01-01

... facilities. 1636.150 Section 1636.150 Administrative Personnel FEDERAL RETIREMENT THRIFT INVESTMENT BOARD... RETIREMENT THRIFT INVESTMENT BOARD § 1636.150 Program accessibility: Existing facilities. (a) General. The... fundamental alteration in the nature of a program or activity or in undue financial and administrative burdens...

[An increase in efficiency of adaptations and a weakening of organism protective reactions in the process of biological evolution].

PubMed

Ivanov, K P

2014-01-01

The main direction of evolution of living organisms is development of the central nervous system and sense organ, an increase of energy exchange development of homoiothermia, development of the more and more complex forms of behavior, an increase in energy expenditure in connection with an increase of the organism activity, and development of adaptation to the habitat. Such fundamental processes were subjected and have been subjected to numerous studies and discussions. However, in different animals there exist different species peculiarities of evolution of physiological functions, from which finally formed are fundamental evolutionary processes. We studied some of these specific processes by dividing them into two categories. The first category is "Increase of efficiency of adaptation" in development of biological evolution. By this term we mean development of amazing by perfection specific physiological mechanisms of adaptive character. The second category is "Weakening of protective organism reactions". By this we understand disturbance of protective mechanisms of the organism immune system, discoordination of movement of leukocytes along microvessels, the absence of efficient collateral circulation in brain and in heart, etc.

The representation of multiplication and division facts in memory.

PubMed

De Brauwer, Jolien; Fias, Wim

2011-01-01

Recently, using a training paradigm, Campbell and Agnew (2009) observed cross-operation response time savings with nonidentical elements (e.g., practice 3 + 2, test 5 - 2) for addition and subtraction, showing that a single memory representation underlies addition and subtraction performance. Evidence for cross-operation savings between multiplication and division have been described frequently (e.g., Campbell, Fuchs-Lacelle, & Phenix, 2006) but they have always been attributed to a mediation strategy (reformulating a division problem as a multiplication problem, e.g., Campbell et al., 2006). Campbell and Agnew (2009) therefore concluded that there exists a fundamental difference between addition and subtraction on the one hand and multiplication and division on the other hand. However, our results suggest that retrieval savings between inverse multiplication and division problems can be observed. Even for small problems (solved by direct retrieval) practicing a division problem facilitated the corresponding multiplication problem and vice versa. These findings indicate that shared memory representations underlie multiplication and division retrieval. Hence, memory and learning processes do not seem to differ fundamentally between addition-subtraction and multiplication-division.

Individual differences in fundamental social motives.

PubMed

Neel, Rebecca; Kenrick, Douglas T; White, Andrew Edward; Neuberg, Steven L

2016-06-01

Motivation has long been recognized as an important component of how people both differ from, and are similar to, each other. The current research applies the biologically grounded fundamental social motives framework, which assumes that human motivational systems are functionally shaped to manage the major costs and benefits of social life, to understand individual differences in social motives. Using the Fundamental Social Motives Inventory, we explore the relations among the different fundamental social motives of Self-Protection, Disease Avoidance, Affiliation, Status, Mate Seeking, Mate Retention, and Kin Care; the relationships of the fundamental social motives to other individual difference and personality measures including the Big Five personality traits; the extent to which fundamental social motives are linked to recent life experiences; and the extent to which life history variables (e.g., age, sex, childhood environment) predict individual differences in the fundamental social motives. Results suggest that the fundamental social motives are a powerful lens through which to examine individual differences: They are grounded in theory, have explanatory value beyond that of the Big Five personality traits, and vary meaningfully with a number of life history variables. A fundamental social motives approach provides a generative framework for considering the meaning and implications of individual differences in social motivation. (PsycINFO Database Record (c) 2016 APA, all rights reserved).

Difference between the vocalizations of two sister species of pigeons explained in dynamical terms.

PubMed

Alonso, R Gogui; Kopuchian, Cecilia; Amador, Ana; Suarez, Maria de Los Angeles; Tubaro, Pablo L; Mindlin, Gabriel B

2016-05-01

Vocal communication is an unique example, where the nonlinear nature of the periphery can give rise to complex sounds even when driven by simple neural instructions. In this work we studied the case of two close-related bird species, Patagioenas maculosa and Patagioenas picazuro, whose vocalizations differ only in the timbre. The temporal modulation of the fundamental frequency is similar in both cases, differing only in the existence of sidebands around the fundamental frequency in the P. maculosa. We tested the hypothesis that the qualitative difference between these vocalizations lies in the nonlinear nature of the syrinx. In particular, we propose that the roughness of maculosa's vocalizations is due to an asymmetry between the right and left vibratory membranes, whose nonlinear dynamics generate the sound. To test the hypothesis, we generated a biomechanical model for vocal production with an asymmetric parameter Q with which we can control the level of asymmetry between these membranes. Using this model we generated synthetic vocalizations with the principal acoustic features of both species. In addition, we confirmed the anatomical predictions by making post mortem inspection of the syrinxes, showing that the species with tonal song (picazuro) has a more symmetrical pair of membranes compared to maculosa.

Difference between the vocalizations of two sister species of pigeons explained in dynamical terms

PubMed Central

Alonso, R. Gogui; Kopuchian, Cecilia; Amador, Ana; de los Angeles Suarez, Maria; Tubaro, Pablo L.; Mindlin, Gabriel B.

2016-01-01

Vocal communication is a unique example where the nonlinear nature of the periphery can give rise to complex sounds even when driven by simple neural instructions. In this work we studied the case of two close-related bird species, Patagioenas maculosa and Patagioenas picazuro, whose vocalizations differ only in the timbre. The temporal modulation of the fundamental frequency is similar in both cases, differing only in the existence of sidebands around the fundamental frequency in the Patagioenas maculosa. We tested the hypothesis that the qualitative difference between these vocalizations lies in the nonlinear nature of the syrinx. In particular, we propose that the roughness of maculosa's vocalizations is due to an asymmetry between the right and left vibratory membranes, whose nonlinear dynamics generate the sound. To test the hypothesis, we generated a biomechanical model for vocal production with an asymmetric parameter Q with which we can control the level of asymmetry between these membranes. Using this model we generated synthetic vocalizations with the principal acoustic features of both species. In addition, we confirmed the anatomical predictions by making post-mortem inspection of the syrinxes, showing that the species with tonal song (picazuro) has a more symmetrical pair of membranes compared to maculosa. PMID:27033354

5 CFR 723.150 - Program accessibility: Existing facilities.

Code of Federal Regulations, 2010 CFR

2010-01-01

... facilities. 723.150 Section 723.150 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT (CONTINUED) CIVIL... ACTIVITIES CONDUCTED BY THE OFFICE OF PERSONNEL MANAGEMENT § 723.150 Program accessibility: Existing... would result in a fundamental alteration in the nature of a program or activity or in undue financial...

Looking forward, not back: Supporting structuralism in the present.

PubMed

McKenzie, Kerry

2016-10-01

The view that the fundamental kind properties are intrinsic properties enjoys reflexive endorsement by most metaphysicians of science. But ontic structural realists deny that there are any fundamental intrinsic properties at all. Given that structuralists distrust intuition as a guide to truth, and given that we currently lack a fundamental physical theory that we could consult instead to order settle the issue, it might seem as if there is simply nowhere for this debate to go at present. However, I will argue that there exists an as-yet untapped resource for arguing for ontic structuralism - namely, the way that fundamentality is conceptualized in our most fundamental physical frameworks. By arguing that physical objects must be subject to the 'Goldilock's principle' if they are to count as fundamental at all, I argue that we can no longer view the majority of properties defining them as intrinsic. As such, ontic structural realism can be regarded as the most promising metaphysics for fundamental physics, and that this is so even though we do not yet claim to know precisely what that fundamental physics is. Copyright © 2016 Elsevier Ltd. All rights reserved.

[The Marketing of Healthcare Services in ENT-Clinics].

PubMed

Teschner, M; Lenarz, T

2016-07-01

The provision of healthcare services in Germany is based on fundamental principles of solidarity and is highly regulated. The question arises which conditions exist for marketing for healthcare services in ENT-clinics in Germany. The marketing options will be elicited using environmentally analytical considerations. The objectives can be achieved using measures derived from external instruments (service policy, pricing policy, distribution policy or communications policy) or from an internal instrument (human resources policy). The policy environment is particularly influenced by the regulatory framework, which particularly restricts the scope for both the pricing and communications policies. All measures must, however, reflect ethical frameworks, which are regarded as the fundamental premise underlying healthcare services and may be at odds with economic factors. Scope for flexibility in pricing exists only within the secondary healthcare market, and even there only to a limited extent. The significance of price in the marketing of healthcare services is thus very low. If marketing activities are to succeed, a market analysis must be carried out exploring the relevant factors for each individual provider. However, the essential precondition for the marketing of healthcare services is trust. The marketing of healthcare services differs from that of business management-oriented enterprises in other branches of economy. In the future the importance of marketing activities will increase. © Georg Thieme Verlag KG Stuttgart · New York.

Universal and idiosyncratic characteristic lengths in bacterial genomes

NASA Astrophysics Data System (ADS)

Junier, Ivan; Frémont, Paul; Rivoire, Olivier

2018-05-01

In condensed matter physics, simplified descriptions are obtained by coarse-graining the features of a system at a certain characteristic length, defined as the typical length beyond which some properties are no longer correlated. From a physics standpoint, in vitro DNA has thus a characteristic length of 300 base pairs (bp), the Kuhn length of the molecule beyond which correlations in its orientations are typically lost. From a biology standpoint, in vivo DNA has a characteristic length of 1000 bp, the typical length of genes. Since bacteria live in very different physico-chemical conditions and since their genomes lack translational invariance, whether larger, universal characteristic lengths exist is a non-trivial question. Here, we examine this problem by leveraging the large number of fully sequenced genomes available in public databases. By analyzing GC content correlations and the evolutionary conservation of gene contexts (synteny) in hundreds of bacterial chromosomes, we conclude that a fundamental characteristic length around 10–20 kb can be defined. This characteristic length reflects elementary structures involved in the coordination of gene expression, which are present all along the genome of nearly all bacteria. Technically, reaching this conclusion required us to implement methods that are insensitive to the presence of large idiosyncratic genomic features, which may co-exist along these fundamental universal structures.

Bounded rationality leads to equilibrium of public goods games.

PubMed

Xu, Zhaojin; Wang, Zhen; Zhang, Lianzhong

2009-12-01

In this work, we introduce a degree of rationality to the public goods games in which players can determine whether or not to participate, and with it a new mechanism has been established. Existence of the bounded rationality would lead to a new equilibrium which differs from the Nash equilibrium and qualitatively explains the fundamental role of loners' payoff for maintaining cooperation. Meanwhile, it is shown how the potential strategy influences the players' decision. Finally, we explicitly demonstrate a rock-scissors-paper dynamics which is a consequence of this model.

Bounded rationality leads to equilibrium of public goods games

NASA Astrophysics Data System (ADS)

Xu, Zhaojin; Wang, Zhen; Zhang, Lianzhong

2009-12-01

In this work, we introduce a degree of rationality to the public goods games in which players can determine whether or not to participate, and with it a new mechanism has been established. Existence of the bounded rationality would lead to a new equilibrium which differs from the Nash equilibrium and qualitatively explains the fundamental role of loners’ payoff for maintaining cooperation. Meanwhile, it is shown how the potential strategy influences the players’ decision. Finally, we explicitly demonstrate a rock-scissors-paper dynamics which is a consequence of this model.

Strongly localized image states of spherical graphitic particles.

PubMed

Gumbs, Godfrey; Balassis, Antonios; Iurov, Andrii; Fekete, Paula

2014-01-01

We investigate the localization of charged particles by the image potential of spherical shells, such as fullerene buckyballs. These spherical image states exist within surface potentials formed by the competition between the attractive image potential and the repulsive centripetal force arising from the angular motion. The image potential has a power law rather than a logarithmic behavior. This leads to fundamental differences in the nature of the effective potential for the two geometries. Our calculations have shown that the captured charge is more strongly localized closest to the surface for fullerenes than for cylindrical nanotube.

Density scaling for multiplets

NASA Astrophysics Data System (ADS)

Nagy, Á.

2011-02-01

Generalized Kohn-Sham equations are presented for lowest-lying multiplets. The way of treating non-integer particle numbers is coupled with an earlier method of the author. The fundamental quantity of the theory is the subspace density. The Kohn-Sham equations are similar to the conventional Kohn-Sham equations. The difference is that the subspace density is used instead of the density and the Kohn-Sham potential is different for different subspaces. The exchange-correlation functional is studied using density scaling. It is shown that there exists a value of the scaling factor ζ for which the correlation energy disappears. Generalized OPM and Krieger-Li-Iafrate (KLI) methods incorporating correlation are presented. The ζKLI method, being as simple as the original KLI method, is proposed for multiplets.

Study on Effects of the Stochastic Delay Probability for 1d CA Model of Traffic Flow

NASA Astrophysics Data System (ADS)

Xue, Yu; Chen, Yan-Hong; Kong, Ling-Jiang

Considering the effects of different factors on the stochastic delay probability, the delay probability has been classified into three cases. The first case corresponding to the brake state has a large delay probability if the anticipant velocity is larger than the gap between the successive cars. The second one corresponding to the following-the-leader rule has intermediate delay probability if the anticipant velocity is equal to the gap. Finally, the third case is the acceleration, which has minimum delay probability. The fundamental diagram obtained by numerical simulation shows the different properties compared to that by the NaSch model, in which there exist two different regions, corresponding to the coexistence state, and jamming state respectively.

An Interpolation Method for Obtaining Thermodynamic Properties Near Saturated Liquid and Saturated Vapor Lines

NASA Technical Reports Server (NTRS)

Nguyen, Huy H.; Martin, Michael A.

2003-01-01

The availability and proper utilization of fluid properties is of fundamental importance in the process of mathematical modeling of propulsion systems. Real fluid properties provide the bridge between the realm of pure analytiis and empirical reality. The two most common approaches used to formulate thermodynamic properties of pure substances are fundamental (or characteristic) equations of state (Helmholtz and Gibbs functions) and a piecemeal approach that is described, for example, in Adebiyi and Russell (1992). This paper neither presents a different method to formulate thermodynamic properties of pure substances nor validates the aforementioned approaches. Rather its purpose is to present a method to be used to facilitate the accurate interpretation of fluid thermodynamic property data generated by existing property packages. There are two parts to this paper. The first part of the paper shows how efficient and usable property tables were generated, with the minimum number of data points, using an aerospace industry standard property package (based on fundamental equations of state approach). The second part describes an innovative interpolation technique that has been developed to properly obtain thermodynamic properties near the saturated liquid and saturated vapor lines.

The effectiveness of a community-based fundamental motor skill intervention in children aged 3-8 years: Results of the "Multimove for Kids" project.

PubMed

Bardid, Farid; Lenoir, Matthieu; Huyben, Floris; De Martelaer, Kristine; Seghers, Jan; Goodway, Jacqueline D; Deconinck, Frederik J A

2017-02-01

The purpose of this study was to examine the effectiveness of a 30-week fundamental motor skill program in typically developing young children and to investigate possible sex differences. A multicenter quasi experimental design was set up for this study which involved 992 children aged 3-8 years. All participants received their typical Physical Education curriculum and habitual movement activities. The intervention group (n=523; 53.5% boys) received a weekly 60-min motor skill session provided by trained local instructors in existing child settings; the control group (n=469; 49.7% boys) received no additional practice. Fundamental motor skills were assessed using the Test of Gross Motor Development, 2nd Edition before and after the intervention. To assess the effect of the intervention and possible sex differences, hierarchical linear regressions analyses were conducted for locomotor and object control gain scores. The intervention group demonstrated a higher gain in both locomotor (β=3.78, SE=1.08, p<0.001) and object control (β=4.46, SE=1.06, p<0.001) skills than the control group. Girls demonstrated a lower gain in object control skills (β=-3.50, SE=0.49, p<0.001) and higher gain in locomotor skills (β=1.01, SE=0.44, p=0.022) than boys, regardless of group. The present study demonstrated the effectiveness of a wide-scale community-based intervention in typically developing children. The sex differences reported may indicate the need to use different pedagogical and instructional strategies to enable boys and girls to develop and master a wide range of motor skills. Copyright © 2016 Sports Medicine Australia. Published by Elsevier Ltd. All rights reserved.

A Study of the Gamma-Ray Burst Fundamental Plane

DOE PAGES

Dainotti, M. G.; Hernandez, X.; Postnikov, S.; ...

2017-10-17

Long gamma-ray bursts (GRBs) with a plateau phase in their X-ray afterglows obey a 3D relation, between the rest-frame time at the end of the plateau, T a, its corresponding X-ray luminosity, L a, and the peak luminosity in the prompt emission, L peak. This 3D relation identifies a GRB fundamental plane whose existence we here confirm. Here we include the most recent GRBs observed by Swift to define a "gold sample" (45 GRBs) and obtain an intrinsic scatter about the plane compatible within 1σ with the previous result. We compare GRB categories, such as short GRBs with extended emissionmore » (SEE), X-ray flashes, GRBs associated with supernovae, a sample of only long-duration GRBs (132), selected from the total sample by excluding GRBs of the previous categories, and the gold sample, composed by GRBs with light curves with good data coverage and relatively flat plateaus. We find that the relation planes for each of these categories are not statistically different from the gold fundamental plane, with the exception of the SSE, which are hence identified as a physically distinct class. The gold fundamental plane has an intrinsic scatter smaller than any plane derived from the other sample categories. Thus, the distance of any particular GRB category from this plane becomes a key parameter. We computed the several category planes with T a as a dependent parameter obtaining for each category smaller intrinsic scatters (reaching a reduction of 24% for the long GRBs). The fundamental plane is independent from several prompt and afterglow parameters.« less

Boundary enhanced effects on the existence of quadratic solitons

NASA Astrophysics Data System (ADS)

Chen, Manna; Zhang, Ting; Li, Wenjie; Lu, Daquan; Guo, Qi; Hu, Wei

2018-05-01

We investigate, both analytically and numerically, the boundary enhanced effects exerted on the quadratic solitons consisting of fundamental waves and oscillatory second harmonics in the presence of boundary conditions. The nonlocal analogy predicts that the soliton for fundamental wave is supported by the balance between equivalent nonlinear confinement and diffraction (or dispersion). Under Snyder and Mitchell's strongly nonlocal approximation, we obtain the analytical soliton solutions both with and without the boundary conditions to show the impact of boundary conditions. We can distinguish explicitly the nonlinear confinement between the second harmonic mutual interaction and the enhanced effects caused by remote boundaries. Those boundary enhanced effects on the existence of solitons can be positive or negative, which depend on both sample size and nonlocal parameter. The piecewise existence regime of solitons can be explained analytically. The analytical soliton solutions are verified by the numerical ones and the discrepancy between them is also discussed.

Being qua becoming: Aristotle's "Metaphysics", quantum physics, and Process Philosophy

NASA Astrophysics Data System (ADS)

Johnson, David Kelley

In Aristotle's First Philosophy, science and philosophy were partners, but with the rise of empiricism, went their separate ways. Metaphysics combined the rational and irrational (i.e. final cause/unmoved mover) elements of existence to equate being with substance, postulating prime matter as pure potential that was actuated by form to create everything. Modern science reveres pure reason and postulates its theory of being by a rigorous scientific methodology. The Standard Model defines matter as energy formed into fundamental particles via forces contained in fields. Science has proved Aristotle's universe wrong in many ways, but as physics delves deeper into the quantum world, empiricism is reaching its limits concerning fundamental questions of existence. To achieve its avowed mission of explaining existence completely, physics must reunite with philosophy in a metascience modeled on the First Philosophy of Aristotle. One theory of being that integrates quantum physics and metaphysics is Process Philosophy.

41 CFR 51-10.150 - Program accessibility: Existing facilities.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 41 Public Contracts and Property Management 1 2010-07-01 2010-07-01 true Program accessibility: Existing facilities. 51-10.150 Section 51-10.150 Public Contracts and Property Management Other Provisions... result in a fundamental alteration in the nature of a program or activity or in undue financial and...

12 CFR 268.707 - Program accessibility: Existing facilities.

Code of Federal Regulations, 2011 CFR

2011-01-01

... Programs and Activities Because of Physical or Mental Disability § 268.707 Program accessibility: Existing facilities. (a) General. The Board shall operate each program or activity so that the program or activity... can demonstrate would result in a fundamental alteration in the nature of a program or activity or in...

12 CFR 268.707 - Program accessibility: Existing facilities.

Code of Federal Regulations, 2010 CFR

2010-01-01

... Programs and Activities Because of Physical or Mental Disability § 268.707 Program accessibility: Existing facilities. (a) General. The Board shall operate each program or activity so that the program or activity... can demonstrate would result in a fundamental alteration in the nature of a program or activity or in...

FUNDAMENTAL SCIENCE AND ENGINEERING OF MERCURY CONTROL IN COAL-FIRED POWER PLANTS

EPA Science Inventory

The paper discusses the existing knowledge base applicable to mercury (Hg) control in coal-fired boilers and outlines the gaps in knowledge that can be filled by experimentation and data gathering. Mercury can be controlled by existing air pollution control devices or by retrofit...

Internal Organization to Serve Part-Time Student Needs.

ERIC Educational Resources Information Center

Massey, T. Benjamin

Two questions are addressed: (1) How can existing organizational structures and practices be developed where none have previously existed? The phenomenon of the adult postsecondary student is a fundamental demographic shift not initiated by the institutions but to which they must nonetheless respond. The organizational structure of the University…

45 CFR 1214.150 - Program accessibility: Existing facilities.

Code of Federal Regulations, 2010 CFR

2010-10-01

... ACTIVITIES CONDUCTED BY ACTION § 1214.150 Program accessibility: Existing facilities. (a) General. The agency shall operate each program or activity so that the program or activity, when viewed in its entirety, is... fundamental alteration in the nature of a program or activity or in undue financial and administrative burdens...

Training of Existing Workers: Issues, Incentives and Models

ERIC Educational Resources Information Center

Mawer, Giselle; Jackson, Elaine

2005-01-01

This report presents issues associated with incentives for training existing workers in small to medium-sized firms, identified through a small sample of case studies from the retail, manufacturing, and building and construction industries. While the majority of employers recognise workforce skill levels are fundamental to the success of the…

Multipartite Entanglement And Firewalls

NASA Astrophysics Data System (ADS)

Luo, Shengqiao; Stoltenberg, Henry; Albrecht, Andreas

2016-03-01

Black holes offer an exciting area to explore the nature of quantum gravity. The classic work on Hawking radiation indicates that black holes should decay via quantum effects, but our ideas about how this might work at a technical level are incomplete. Recently Almheiri-Marolf-Polchinski-Sully AMPS have noted an apparent paradox in reconciling fundamental properties of quantum mechanics with standard beliefs about black holes. One way to resolve the paradox is to postulate the existence of a ``firewall'' inside the black hole horizon which prevents objects from falling smoothly toward the singularity. A fundamental limitation on the behavior of quantum entanglement known as ``monogamy'' plays a key role in the AMPS argument. Our goal is to study and apply many-body entanglement theory to consider the entanglement among different parts of Hawking radiation and black holes. We identified an example which could change the AMPS accounting of quantum entanglement and perhaps eliminating the need for a firewall. Looking at different many body entanglement measures and their monogamy properties can tell us subtle ways in which different subsystems can share their entanglement. Specific measures we consider include negativity, concurrence, and mutual information. Taking insights from these different measures, we constructed toy models for black hole decay which have different entanglement behaviors than those assumed by AMPS. We hope to use our effective toy model to demonstrate interesting new ways of thinking about black holes.

Average ambulatory measures of sound pressure level, fundamental frequency, and vocal dose do not differ between adult females with phonotraumatic lesions and matched control subjects

PubMed Central

Van Stan, Jarrad H.; Mehta, Daryush D.; Zeitels, Steven M.; Burns, James A.; Barbu, Anca M.; Hillman, Robert E.

2015-01-01

Objectives Clinical management of phonotraumatic vocal fold lesions (nodules, polyps) is based largely on assumptions that abnormalities in habitual levels of sound pressure level (SPL), fundamental frequency (f0), and/or amount of voice use play a major role in lesion development and chronic persistence. This study used ambulatory voice monitoring to evaluate if significant differences in voice use exist between patients with phonotraumatic lesions and normal matched controls. Methods Subjects were 70 adult females: 35 with vocal fold nodules or polyps and 35 age-, sex-, and occupation-matched normal individuals. Weeklong summary statistics of voice use were computed from anterior neck surface acceleration recorded using a smartphone-based ambulatory voice monitor. Results Paired t-tests and Kolmogorov-Smirnov tests resulted in no statistically significant differences between patients and matched controls regarding average measures of SPL, f0, vocal dose measures, and voicing/voice rest periods. Paired t-tests comparing f0 variability between the groups resulted in statistically significant differences with moderate effect sizes. Conclusions Individuals with phonotraumatic lesions did not exhibit differences in average ambulatory measures of vocal behavior when compared with matched controls. More refined characterizations of underlying phonatory mechanisms and other potentially contributing causes are warranted to better understand risk factors associated with phonotraumatic lesions. PMID:26024911

Emergence of Orientation Selectivity in the Mammalian Visual Pathway

PubMed Central

Scholl, Benjamin; Tan, Andrew Y. Y.; Corey, Joseph

2013-01-01

Orientation selectivity is a property of mammalian primary visual cortex (V1) neurons, yet its emergence along the visual pathway varies across species. In carnivores and primates, elongated receptive fields first appear in V1, whereas in lagomorphs such receptive fields emerge earlier, in the retina. Here we examine the mouse visual pathway and reveal the existence of orientation selectivity in lateral geniculate nucleus (LGN) relay cells. Cortical inactivation does not reduce this orientation selectivity, indicating that cortical feedback is not its source. Orientation selectivity is similar for LGN relay cells spiking and subthreshold input to V1 neurons, suggesting that cortical orientation selectivity is inherited from the LGN in mouse. In contrast, orientation selectivity of cat LGN relay cells is small relative to subthreshold inputs onto V1 simple cells. Together, these differences show that although orientation selectivity exists in visual neurons of both rodents and carnivores, its emergence along the visual pathway, and thus its underlying neuronal circuitry, is fundamentally different. PMID:23804085

An Autonomous Distributed Fault-Tolerant Local Positioning System

NASA Technical Reports Server (NTRS)

Malekpour, Mahyar R.

2017-01-01

We describe a fault-tolerant, GPS-independent (Global Positioning System) distributed autonomous positioning system for static/mobile objects and present solutions for providing highly-accurate geo-location data for the static/mobile objects in dynamic environments. The reliability and accuracy of a positioning system fundamentally depends on two factors; its timeliness in broadcasting signals and the knowledge of its geometry, i.e., locations and distances of the beacons. Existing distributed positioning systems either synchronize to a common external source like GPS or establish their own time synchrony using a scheme similar to a master-slave by designating a particular beacon as the master and other beacons synchronize to it, resulting in a single point of failure. Another drawback of existing positioning systems is their lack of addressing various fault manifestations, in particular, communication link failures, which, as in wireless networks, are increasingly dominating the process failures and are typically transient and mobile, in the sense that they typically affect different messages to/from different processes over time.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Binder, Tobias; Covi, Laura; Kamada, Ayuki

Dark Matter (DM) models providing possible alternative solutions to the small-scale crisis of the standard cosmology are nowadays of growing interest. We consider DM interacting with light hidden fermions via well-motivated fundamental operators showing the resultant matter power spectrum is suppressed on subgalactic scales within a plausible parameter region. Our basic description of the evolution of cosmological perturbations relies on a fully consistent first principles derivation of a perturbed Fokker-Planck type equation, generalizing existing literature. The cosmological perturbation of the Fokker-Planck equation is presented for the first time in two different gauges, where the results transform into each other accordingmore » to the rules of gauge transformation. Furthermore, our focus lies on a derivation of a broadly applicable and easily computable collision term showing important phenomenological differences to other existing approximations. As one of the main results and concerning the small-scale crisis, we show the equal importance of vector and scalar boson mediated interactions between the DM and the light fermions.« less

The Fundamental Solution of the Linearized Navier Stokes Equations for Spinning Bodies in Three Spatial Dimensions Time Dependent Case

NASA Astrophysics Data System (ADS)

Thomann, Enrique A.; Guenther, Ronald B.

2006-02-01

Explicit formulae for the fundamental solution of the linearized time dependent Navier Stokes equations in three spatial dimensions are obtained. The linear equations considered in this paper include those used to model rigid bodies that are translating and rotating at a constant velocity. Estimates extending those obtained by Solonnikov in [23] for the fundamental solution of the time dependent Stokes equations, corresponding to zero translational and angular velocity, are established. Existence and uniqueness of solutions of these linearized problems is obtained for a class of functions that includes the classical Lebesgue spaces L p (R 3), 1 < p < ∞. Finally, the asymptotic behavior and semigroup properties of the fundamental solution are established.

Different evolution dynamics of vector solitons depending on their polarization states

NASA Astrophysics Data System (ADS)

Chen, Wei-Cheng; Chen, Guo-Jie

2014-03-01

There are three types of temporal evolution dynamics of vector solitons observed in a ring fiber laser with a semiconductor saturable absorption mirror (SESAM) as a mode-locker. It is found that the polarization property of vector solitons is an important factor for achieving different evolution dynamics. The vector soliton with a uniform polarization state across the whole pulse profile and zero polarization extinction ratio operates at a fundamental repetition rate with a single pulse profile. The elliptically polarized vector soliton with a larger polarization extinction ratio exhibits a harmonic pulse train. The soliton bunching with multi-peak structures exists between the above two states and shows elliptical polarization with a small polarization extinction ratio.

Simulating Statistical Power in Latent Growth Curve Modeling: A Strategy for Evaluating Age-Based Changes in Cognitive Resources

NASA Astrophysics Data System (ADS)

von Oertzen, Timo; Ghisletta, Paolo; Lindenberger, Ulman

Variability across and within individuals is a fundamental property of adult age changes in behavior [20, 21, 24]. Some people seem young for their age, others seem old; shining examples of older individuals who maintained high levels of intellectual functioning well into very old age, such as Johann Wolfgang von Goethe or Sophocles, stand in contrast to individuals whose cognitive resources are depleted by the time they reach later adulthood. A similar contrast exists between different intellectual abilities. For example, if one looks at the speed needed to identify and discriminate between different percepts, one is likely to find monotonic decline after late adolescence and early adulthood.

The Discontinuity of Human Existence, Part I. The Fundamental Concepts of Human Existence and the Relation between the Singular and the Super Singular. No. 50.

ERIC Educational Resources Information Center

Rasmussen, Ole Elstrup

The first in a series of three reports on philosophy of human existence focuses on human activity in the economic context, or more specifically, the role of the entrepreneur. A variety of treatments of entrepreneurship in the literature of economics and cognitive psychology are examined, and it is found that analyses of entrepreneurship are…

[Pain medicine from intercultural and gender-related perspectives].

PubMed

Schiltenwolf, M; Pogatzki-Zahn, E M

2015-10-01

Cultural setting and sex and gender of the patient are important factors affecting the occurrence, severity, clinical course and prognosis of pain and pain-related diseases. Intercultural differences in the perception and verbal expression of symptoms and emotional function are fundamental and it is important to realize these differences in order to understand patients with a migration background. A trusting doctor-patient relationship is generally very sensitive and it is even more difficult to establish when differences in the cultural background impair mutual understanding. Regarding sex and gender there is evidence that females are more susceptible to developing chronic pain conditions, experience more severe pain and respond differently to pain therapy; however, results of recent studies indicate that females are not that different to males when comparing several modalities of experimental pain (although some differences exist). Similarly, sex and gender differences in postoperative pain seem to exist but the differences are relatively small when pain scores are compared. Other aspects, such as the response to analgesics and role of psychosocial factors should be addressed when sex and gender aspects are studied. Similarly, sex and gender differences in the prevalence of chronic pain exist but the results of some studies, e.g. those controlling for confounders, are not very clear. Research is needed to delineate the role of specific aspects affecting sex and gender differences and the underlying mechanisms (e.g. reduced inhibitory control, hormones, psychological aspects and social factors). Altogether, we need to open our minds to some intercultural and sex and gender aspects in the clinical setting. For sex and gender differences we may need a more biopsychosocial approach to understand the underlying differences and differentiate between sex and gender and sex and gender-associated aspects for acute and chronic pain.

The relationship between adolescents' physical activity, fundamental movement skills and weight status.

PubMed

O' Brien, Wesley; Belton, Sarahjane; Issartel, Johann

2016-01-01

The aim of this study was to determine if a potential relationship among physical activity (PA), fundamental movement skills and weight status exists amongst early adolescent youth. Participants were a sample of 85 students; 54 boys (mean age = 12.94 ± 0.33 years) and 31 girls (mean age = 12.75 ± 0.43 years). Data gathered during physical education class included PA (accelerometry), fundamental movement skills and anthropometric measurements. Standard multiple regression revealed that PA and total fundamental movement skill proficiency scores explained 16.5% (P < 0.001) of the variance in the prediction of body mass index. Chi-square tests for independence further indicated that compared with overweight or obese adolescents, a significantly higher proportion of adolescents classified as normal weight achieved mastery/near-mastery in fundamental movement skills. Results from the current investigation indicate that weight status is an important correlate of fundamental movement skill proficiency during adolescence. Aligned with most recent research, school- and community-based programmes that include developmentally structured learning experiences delivered by specialists can significantly improve fundamental movement skill proficiency in youth.

What do we mean by sensitivity analysis? The need for comprehensive characterization of "global" sensitivity in Earth and Environmental systems models

NASA Astrophysics Data System (ADS)

Razavi, Saman; Gupta, Hoshin V.

2015-05-01

Sensitivity analysis is an essential paradigm in Earth and Environmental Systems modeling. However, the term "sensitivity" has a clear definition, based in partial derivatives, only when specified locally around a particular point (e.g., optimal solution) in the problem space. Accordingly, no unique definition exists for "global sensitivity" across the problem space, when considering one or more model responses to different factors such as model parameters or forcings. A variety of approaches have been proposed for global sensitivity analysis, based on different philosophies and theories, and each of these formally characterizes a different "intuitive" understanding of sensitivity. These approaches focus on different properties of the model response at a fundamental level and may therefore lead to different (even conflicting) conclusions about the underlying sensitivities. Here we revisit the theoretical basis for sensitivity analysis, summarize and critically evaluate existing approaches in the literature, and demonstrate their flaws and shortcomings through conceptual examples. We also demonstrate the difficulty involved in interpreting "global" interaction effects, which may undermine the value of existing interpretive approaches. With this background, we identify several important properties of response surfaces that are associated with the understanding and interpretation of sensitivities in the context of Earth and Environmental System models. Finally, we highlight the need for a new, comprehensive framework for sensitivity analysis that effectively characterizes all of the important sensitivity-related properties of model response surfaces.

Harmonic lasing in x-ray free electron lasers

NASA Astrophysics Data System (ADS)

Schneidmiller, E. A.; Yurkov, M. V.

2012-08-01

Harmonic lasing in a free electron laser with a planar undulator (under the condition that the fundamental frequency is suppressed) might be a cheap and efficient way of extension of wavelength ranges of existing and planned x-ray free electron laser (FEL) facilities. Contrary to nonlinear harmonic generation, harmonic lasing can provide much more intense, stable, and narrow-band FEL beam which is easier to handle due to the suppressed fundamental frequency. In this paper we perform a parametrization of the solution of the eigenvalue equation for lasing at odd harmonics, and present an explicit expression for FEL gain length, taking into account all essential effects. We propose and discuss methods for suppression of the fundamental harmonic. We also suggest a combined use of harmonic lasing and lasing at the retuned fundamental wavelength in order to reduce bandwidth and to increase brilliance of x-ray beam at saturation. Considering 3rd harmonic lasing as a practical example, we come to the conclusion that it is much more robust than usually thought, and can be widely used in the existing or planned x-ray FEL (XFEL) facilities. In particular, Linac Coherent Light Source (LCLS) after a minor modification can lase to saturation at the 3rd harmonic up to the photon energy of 25-30 keV providing multigigawatt power level and narrow bandwidth. As for the European XFEL, harmonic lasing would allow one to extend operating range (ultimately up to 100 keV), to reduce FEL bandwidth and to increase brilliance, to enable two-color operation for pump-probe experiments, and to provide more flexible operation at different electron energies. Similar improvements can be realized in other x-ray FEL facilities with gap-tunable undulators like FLASH II, SACLA, LCLS II, etc. Harmonic lasing can be an attractive option for compact x-ray FELs (driven by electron beams with a relatively low energy), allowing the use of the standard undulator technology instead of small-gap in-vacuum devices. Finally, in this paper we discover that in a part of the parameter space, corresponding to the operating range of soft x-ray beam lines of x-ray FEL facilities (like SASE3 beam line of the European XFEL), harmonics can grow faster than the fundamental wavelength. This feature can be used in some experiments, but might also be an unwanted phenomenon, and we discuss possible measures to diminish it.

Systematic Regional Variations in Purkinje Cell Spiking Patterns

PubMed Central

Xiao, Jianqiang; Cerminara, Nadia L.; Kotsurovskyy, Yuriy; Aoki, Hanako; Burroughs, Amelia; Wise, Andrew K.; Luo, Yuanjun; Marshall, Sarah P.; Sugihara, Izumi; Apps, Richard; Lang, Eric J.

2014-01-01

In contrast to the uniform anatomy of the cerebellar cortex, molecular and physiological studies indicate that significant differences exist between cortical regions, suggesting that the spiking activity of Purkinje cells (PCs) in different regions could also show distinct characteristics. To investigate this possibility we obtained extracellular recordings from PCs in different zebrin bands in crus IIa and vermis lobules VIII and IX in anesthetized rats in order to compare PC firing characteristics between zebrin positive (Z+) and negative (Z−) bands. In addition, we analyzed recordings from PCs in the A2 and C1 zones of several lobules in the posterior lobe, which largely contain Z+ and Z− PCs, respectively. In both datasets significant differences in simple spike (SS) activity were observed between cortical regions. Specifically, Z− and C1 PCs had higher SS firing rates than Z+ and A2 PCs, respectively. The irregularity of SS firing (as assessed by measures of interspike interval distribution) was greater in Z+ bands in both absolute and relative terms. The results regarding systematic variations in complex spike (CS) activity were less consistent, suggesting that while real differences can exist, they may be sensitive to other factors than the cortical location of the PC. However, differences in the interactions between SSs and CSs, including the post-CS pause in SSs and post-pause modulation of SSs, were also consistently observed between bands. Similar, though less strong trends were observed in the zonal recordings. These systematic variations in spontaneous firing characteristics of PCs between zebrin bands in vivo, raises the possibility that fundamental differences in information encoding exist between cerebellar cortical regions. PMID:25144311

Novel carbon-ion fuel cells. Quarterly technical report No. 10, January 1, 1996--March 31, 1996

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cocks, F.H.

1996-08-01

This report presents research to develop an entirely new, fundamentally different class of fuel cell using a solid electrolyte that transports carbon ions. This fuel cell would use solid carbon dissolved in molten metal as a fuel reservoir and anode; expensive gaseous or liquid fuel would not be required. A high temperature fuel cell based on a carbon ion membrane/electrolyte would operate in a way like yttria-doped zirconia solid oxide fuel cells; however, the fuel cell would transport the C ion from a fuel source to O{sub 2} in the atmosphere. Such fuel cells, operating above 1000 C, would producemore » an exhaust gas that could be fed directly into existing boilers, and could thus act as ``topping cycles`` to existing power plant steam cycles.« less

A Study of the Gamma-Ray Burst Fundamental Plane

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dainotti, M. G.; Hernandez, X.; Postnikov, S.

2017-10-20

Long gamma-ray bursts (GRBs) with a plateau phase in their X-ray afterglows obey a 3D relation, between the rest-frame time at the end of the plateau, T {sub a} , its corresponding X-ray luminosity, L {sub a} , and the peak luminosity in the prompt emission, L {sub peak}. This 3D relation identifies a GRB fundamental plane whose existence we here confirm. Here we include the most recent GRBs observed by Swift to define a “gold sample” (45 GRBs) and obtain an intrinsic scatter about the plane compatible within 1 σ with the previous result. We compare GRB categories, suchmore » as short GRBs with extended emission (SEE), X-ray flashes, GRBs associated with supernovae, a sample of only long-duration GRBs (132), selected from the total sample by excluding GRBs of the previous categories, and the gold sample, composed by GRBs with light curves with good data coverage and relatively flat plateaus. We find that the relation planes for each of these categories are not statistically different from the gold fundamental plane, with the exception of the SSE, which are hence identified as a physically distinct class. The gold fundamental plane has an intrinsic scatter smaller than any plane derived from the other sample categories. Thus, the distance of any particular GRB category from this plane becomes a key parameter. We computed the several category planes with T {sub a} as a dependent parameter obtaining for each category smaller intrinsic scatters (reaching a reduction of 24% for the long GRBs). The fundamental plane is independent from several prompt and afterglow parameters.« less

Multipartite entanglement and firewalls

NASA Astrophysics Data System (ADS)

Luo, Shengqiao; Stoltenberg, Henry; Albrecht, Andreas

2017-03-01

Black holes offer an exciting area to explore the nature of quantum gravity. The classic work on Hawking radiation indicates that black holes should decay via quantum effects, but our ideas about how this might work at a technical level are incomplete. Recently Almheiri-Marolf-Polchinski-Sully (AMPS) have noted an apparent paradox in reconciling fundamental properties of quantum mechanics with standard beliefs about black holes. One way to resolve the paradox is to postulate the existence of a "firewall" inside the black hole horizon which prevents objects from falling smoothly toward the singularity. A fundamental limitation on the behavior of quantum entanglement known as "monogamy" plays a key role in the AMPS argument. Our goal is to study and apply many-body entanglement theory to consider the entanglement among different parts of Hawking radiation and black holes. Using the multipartite entanglement measure called negativity, we identify an example which could change the AMPS accounting of quantum entanglement and perhaps eliminate the need for a firewall. Specifically, we constructed a toy model for black hole decay which has different entanglement behavior than that assumed by AMPS. We discuss the additional steps that would be needed to bring lessons from our toy model to our understanding of realistic black holes.

Structural and vibrational investigations of a neurotransmitter molecule: Serotonin (5-hydroxy tryptamine)

NASA Astrophysics Data System (ADS)

Jha, Omkant; Yadav, R. A.

2016-11-01

Structural and vibrational studies have been carried out for the most stable conformer of serotonin (5-HT) at the DFT/B3LYP/6-311++G** level using the Gaussian 09 software. In light of the computed vibrational parameters the observed IR and Raman frequencies have been analyzed. To help assign the vibrational fundamentals the GAR2PED software has been used to compute PEDs. Several of the fundamentals are drastically changed in going from indole to serotonin. The two NH bonds of the NH2 group are slightly different possibly due to bonding of the two H atoms of the NH2 group with different atoms. The rocking and wagging modes of the NH2 groups show mixing with the other modes while the remaining four modes are pure group modes. The Kekule phenyl ring stretching mode is found to remain almost unchanged. The HOMO-LUMO energy gap supports to pharmacological active property of the serotonin molecule. The HOMO and LUMO study suggests the existence of charge transfer within the molecule. The NBO analysis has been carried out to gather information regarding the proper and improper hydrogen bonds.

Phonon Surface Scattering and Thermal Energy Distribution in Superlattices.

PubMed

Kothari, Kartik; Maldovan, Martin

2017-07-17

Thermal transport at small length scales has attracted significant attention in recent years and various experimental and theoretical methods have been developed to establish the reduced thermal conductivity. The fundamental understanding of how phonons move and the physical mechanisms behind nanoscale thermal transport, however, remains poorly understood. Here we move beyond thermal conductivity calculations and provide a rigorous and comprehensive physical description of thermal phonon transport in superlattices by solving the Boltzmann transport equation and using the Beckman-Kirchhoff surface scattering theory with shadowing to precisely describe phonon-surface interactions. We show that thermal transport in superlattices can be divided in two different heat transport modes having different physical properties at small length scales: layer-restricted and extended heat modes. We study how interface conditions, periodicity, and composition can be used to manipulate the distribution of thermal energy flow among such layer-restricted and extended heat modes. From predicted frequency and mean free path spectra of superlattices, we also investigate the existence of wave effects. The results and insights in this paper advance the fundamental understanding of heat transport in superlattices and the prospects of rationally designing thermal systems with tailored phonon transport properties.

Probing atomic Higgs-like forces at the precision frontier

NASA Astrophysics Data System (ADS)

Delaunay, Cédric; Ozeri, Roee; Perez, Gilad; Soreq, Yotam

2017-11-01

We propose a novel approach to probe new fundamental interactions using isotope shift spectroscopy in atomic clock transitions. As a concrete toy example we focus on the Higgs boson couplings to the building blocks of matter: the electron and the up and down quarks. We show that the attractive Higgs force between nuclei and their bound electrons, which is poorly constrained, might induce effects that are larger than the current experimental sensitivities. More generically, we discuss how new interactions between the electron and the neutrons, mediated via light new degrees of freedom, may lead to measurable nonlinearities in a King plot comparison between isotope shifts of two different transitions. Given state-of-the-art accuracy in frequency comparison, isotope shifts have the potential to be measured with sub-Hz accuracy, thus potentially enabling the improvement of current limits on new fundamental interactions. A candidate atomic system for this measurement requires two different clock transitions and four zero nuclear spin isotopes. We identify several systems that satisfy this requirement and also briefly discuss existing measurements. We consider the size of the effect related to the Higgs force and the requirements for it to produce an observable signal.

The Evolution of the Brain, the Human Nature of Cortical Circuits, and Intellectual Creativity

PubMed Central

DeFelipe, Javier

2011-01-01

The tremendous expansion and the differentiation of the neocortex constitute two major events in the evolution of the mammalian brain. The increase in size and complexity of our brains opened the way to a spectacular development of cognitive and mental skills. This expansion during evolution facilitated the addition of microcircuits with a similar basic structure, which increased the complexity of the human brain and contributed to its uniqueness. However, fundamental differences even exist between distinct mammalian species. Here, we shall discuss the issue of our humanity from a neurobiological and historical perspective. PMID:21647212

The Historical Basis of Engineering Ethics

NASA Astrophysics Data System (ADS)

Furuya, Keiichi

There are different objects and motives between scientists and engineers. Science is to create new knowledge (episteme), while technology (techne) is to create new utility. Both types of social responsibility are required for engineer, because modern technology is tightly connected with science. The relationship between ethics for scientists and engineers is discussed as an evolution of ethical objects. A short history of engineering societies in U.S.A. and Japan are introduced with their ethical perspectives. As a conclusion, respect for fundamental rights for existence of those who stand in, with, and around engineers and their societies is needed for better engineering ethics.

Fundamental limits of measurement in telecommunications: Experimental and modeling studies in a test optical network on proposal for the reform of telecommunication quantitations

NASA Astrophysics Data System (ADS)

Egan, James; McMillan, Normal; Denieffe, David

2011-08-01

Proposals for a review of the limits of measurement for telecommunications are made. The measures are based on adapting work from the area of chemical metrology for the field of telecommunications. Currie has introduced recommendations for defining the limits of measurement in chemical metrology and has identified three key fundamental limits of measurement. These are the critical level, the detection limit and the determination limit. Measurements on an optical system are used to illustrate the utility of these measures and discussion is given into the advantages of using these fundamental quantitations over existing methods.

Theoretically Investigating the Nature of Spacetime- A grand definition of what clocks measure

NASA Astrophysics Data System (ADS)

Egie, Meru

Einstein's special theory of relativity established time as a dimension of reality, explaining physically the mathematical stipulations of Lorentz transformation equations that are required to keep the validity of Maxwell's equations of light and explain the null result of Michelson-Morley experiment. Our current understanding of time is relativistic, that is time is not absolute but runs differently depending on the frame of reference, yet this description uncovers so little about the fundamental reality of time. Using mathematical arguments derived from a simple thought experiment, both Lorentz transformation equations and Einstein's far reaching conclusions of his 1905 paper on the electrodynamics of moving bodies are obtained with arguments that suggest no prior knowledge of both Einstein and Lorentz works. This work attempts uncovering the fundamental nature of what clocks measure and a major implication of this is that the fourth dimension could just be a persistent illusion caused by the existence of space. Gratitude to Mr. Jon Egie for his support and Aghogo Rita for her listening ears.

Experimental Investigations on Effect of Damage on Vibration Characteristics of a Reinforced Concrete Beam

NASA Astrophysics Data System (ADS)

Srinivas, V.; Jeyasehar, C. Antony; Ramanjaneyulu, K.; Sasmal, Saptarshi

2012-02-01

Need for developing efficient non-destructive damage assessment procedures for civil engineering structures is growing rapidly towards structural health assessment and management of existing structures. Damage assessment of structures by monitoring changes in the dynamic properties or response of the structure has received considerable attention in recent years. In the present study, damage assessment studies have been carried out on a reinforced concrete beam by evaluating the changes in vibration characteristics with the changes in damage levels. Structural damage is introduced by static load applied through a hydraulic jack. After each stage of damage, vibration testing is performed and system parameters were evaluated from the measured acceleration and displacement responses. Reduction in fundamental frequencies in first three modes is observed for different levels of damage. It is found that a consistent decrease in fundamental frequency with increase in damage magnitude is noted. The beam is numerically simulated and found that the vibration characteristics obtained from the measured data are in close agreement with the numerical data.

On Rosen's theory of gravity and cosmology

NASA Technical Reports Server (NTRS)

Barnes, R. C.

1980-01-01

Formal similarities between general relativity and Rosen's bimetric theory of gravity were used to analyze various bimetric cosmologies. The following results were found: (1) physically plausible model universes which have a flat static background metric, have a Robertson-Walker fundamental metric, and which allow co-moving coordinates do not exist in bimetric cosmology. (2) it is difficult to use the Robertson-Walker metric for both the background metric (gamma mu nu) and the fundamental metric tensor of Riemannian geometry( g mu nu) and require that g mu nu and gamma mu nu have different time dependences. (3) A consistency relation for using co-moving coordinates in bimetric cosmology was derived. (4) Certain spatially flat bimetric cosmologies of Babala were tested for the presence of particle horizons. (5) An analytic solution for Rosen's k = +1 model was found. (6) Rosen's singularity free k = +1 model arises from what appears to be an arbitary choice for the time dependent part of gamma mu nu.

Wall of fundamental constants

DOE Office of Scientific and Technical Information (OSTI.GOV)

Olive, Keith A.; School of Physics and Astronomy, University of Minnesota, Minneapolis, Minnesota, 55455; Peloso, Marco

2011-02-15

We consider the signatures of a domain wall produced in the spontaneous symmetry breaking involving a dilatonlike scalar field coupled to electromagnetism. Domains on either side of the wall exhibit slight differences in their respective values of the fine-structure constant, {alpha}. If such a wall is present within our Hubble volume, absorption spectra at large redshifts may or may not provide a variation in {alpha} relative to the terrestrial value, depending on our relative position with respect to the wall. This wall could resolve the contradiction between claims of a variation of {alpha} based on Keck/Hires data and of themore » constancy of {alpha} based on Very Large Telescope data. We derive the properties of the wall and the parameters of the underlying microscopic model required to reproduce the possible spatial variation of {alpha}. We discuss the constraints on the existence of the low-energy domain wall and describe its observational implications concerning the variation of the fundamental constants.« less

Dramatic genotypic difference in, and effect of genetic crossing on, tissue culture-induced mobility of retrotransposon Tos17 in rice.

PubMed

Lin, Chunjing; Lin, Xiuyun; Hu, Lanjuan; Yang, Jingjing; Zhou, Tianqi; Long, Likun; Xu, Chunming; Xing, Shaochen; Qi, Bao; Dong, Yingshan; Liu, Bao

2012-11-01

KEY MESSAGE : We show for the first time that intraspecific crossing may impact mobility of the prominent endogenous retrotransposon Tos17 under tissue culture conditions in rice. Tos17, an endogenous copia retrotransposon of rice, is transpositionally active in tissue culture. To study whether there exists fundamental genotypic difference in the tissue culture-induced mobility of Tos17, and if so, whether the difference is under genetic and/or epigenetic control, we conducted this investigation. We show that dramatic difference in tissue culture-induced Tos17 mobility exists among different rice pure-line cultivars sharing the same maternal parent: of the three lines studied that harbor Tos17, two showed mobilization of Tos17, which accrued in proportion to subculture duration, while the third line showed total quiescence (immobility) of the element and the fourth line did not contain the element. In reciprocal F1 hybrids between Tos17-mobile and -immobile (or absence) parental lines, immobility was dominant over mobility. In reciprocal F1 hybrids between both Tos17-mobile parental lines, an additive or synergistic effect on mobility of the element was noticed. In both types of reciprocal F1 hybrids, clear difference in the extent of Tos17 mobility was noted between crossing directions. Given that all lines share the same maternal parent, this observation indicates the existence of epigenetic parent-of-origin effect. We conclude that the tissue culture-induced mobility of Tos17 in rice is under complex genetic and epigenetic control, which can be either enhanced or repressed by intraspecific genetic crossing.

The Democratic Public to Be Brought into Existence and Education as Secularization

ERIC Educational Resources Information Center

Oliverio, Stefano

2014-01-01

The paper tackles the fundamental question of whether democracy has by now been turned into a meaningless liturgy of a past religion and proposes a Deweyan answer which points to the need to fully realize modernity in order to bring into existence a genuine democracy. By deploying an archaeological reading of "The Public and Its…

Two-dimensional symbiotic solitons and vortices in binary condensates with attractive cross-species interaction

PubMed Central

Ma, Xuekai; Driben, Rodislav; Malomed, Boris A.; Meier, Torsten; Schumacher, Stefan

2016-01-01

We consider a two-dimensional (2D) two-component spinor system with cubic attraction between the components and intra-species self-repulsion, which may be realized in atomic Bose-Einstein condensates, as well as in a quasi-equilibrium condensate of microcavity polaritons. Including a 2D spatially periodic potential, which is necessary for the stabilization of the system against the critical collapse, we use detailed numerical calculations and an analytical variational approximation (VA) to predict the existence and stability of several types of 2D symbiotic solitons in the spinor system. Stability ranges are found for symmetric and asymmetric symbiotic fundamental solitons and vortices, including hidden-vorticity (HV) modes, with opposite vorticities in the two components. The VA produces exceptionally accurate predictions for the fundamental solitons and vortices. The fundamental solitons, both symmetric and asymmetric ones, are completely stable, in either case when they exist as gap solitons or regular ones. The symmetric and asymmetric vortices are stable if the inter-component attraction is stronger than the intra-species repulsion, while the HV modes have their stability region in the opposite case. PMID:27703235

Perception of the fundamental frequencies of children's voices by trained and untrained listeners.

PubMed

Wilson, F B; Wellen, C J; Kimbarow, M L

1983-10-01

This study was designed to determine if trained voice clinicians were better than untrained listeners in judging differences in the fundamental frequencies of children's voices. We also attempted to determine the degree of difference in fundamental frequency necessary for accurate judgments. Finally, ability to perceive pitch differences in speaking voices was correlated with ability to judge puretone stimuli. Results indicated that trained clinicians were no better at judging average fundamental frequency than were untrained listeners. Both groups performed at chance level until differences in vocal fundamental frequency exceeded 20 Hz. Finally, there was no correlation between subjects' success on standardized puretone pitch tests and ability to judge average pitch in the speaking voice.

Amalgamation of Marginal Gains (AMG) as a potential system to deliver high-quality fundamental nursing care: A qualitative analysis of interviews from high-performance AMG sports and healthcare practitioners.

PubMed

Pentecost, Claire; Richards, David A; Frost, Julia

2017-11-28

To investigate the components of the Amalgamation of Marginal Gains (AMG) performance system to identify a set of principles that can be built into an innovative fundamental nursing care protocol. Nursing is urged to refocus on its fundamental care activities, but little evidence exists to guide practising nurses. Fundamental care is a combination of many small behaviours aimed at meeting a person's care needs. AMG is a successful system of performance management that focusses on small (or marginal) gains, and might provide a new delivery framework for fundamental nursing care. Qualitative interview study. We undertook in-depth interviews with healthcare and sports professionals experienced in AMG. We analysed data using open coding in a framework analysis, and then interrogated the data using Normalisation Process Theory (NPT). We triangulated findings with AMG literature to develop an intervention logic model. We interviewed 20 AMG practitioners. AMG processes were as follows: focusing on many details to optimise performance, identification of marginal gains using different sources, understanding current versus optimum performance, monitoring at micro and macro level and strong leadership. Elements of normalisation were as follows: whole team belief in AMG to improve performance, a collective desire for excellence using evidence-based actions, whole team engagement to identify choose and implement changes, and individual and group responsibility for monitoring performance. We have elicited the processes described by AMG innovators in health care and sport and have mapped the normalisation potential and work required to embed such a system into nursing practice. The development of our logic model based on AMG and NPT may provide a practical framework for improving fundamental nursing care and is ripe for further development and testing in clinical trials. © 2017 The Authors Journal of Clinical Nursing Published by John Wiley & Sons Ltd.

40 CFR 403.13 - Variances from categorical pretreatment standards for fundamentally different factors.

Code of Federal Regulations, 2012 CFR

2012-07-01

... for fundamentally different factors. (a) Definition. The term Requester means an Industrial User or a... a certain Industrial User within an industrial category or subcategory. This will only be done if data specific to that Industrial User indicates it presents factors fundamentally different from those...

Comparison of fundamental natural period of masonry and reinforced concrete buildings retrieved from experimental campaigns performed in Italy, Greece and Spain

NASA Astrophysics Data System (ADS)

Nigro, Antonella; Ponzo, Felice C.; Ditommaso, Rocco; Auletta, Gianluca; Iacovino, Chiara; Nigro, Domenico S.; Soupios, Pantelis; García-Fernández, Mariano; Jimenez, Maria-Jose

2017-04-01

Aim of this study is the experimental estimation of the dynamic characteristics of existing buildings and the comparison of the related fundamental natural period of the buildings (masonry and reinforced concrete) located in Basilicata (Italy), in Madrid (Spain) and in Crete (Greece). Several experimental campaigns, on different kind of structures all over the world, have been performed in the last years with the aim of proposing simplified relationships to evaluate the fundamental period of buildings. Most of formulas retrieved from experimental analyses provide vibration periods smaller than those suggested by the Italian Seismic Code (NTC2008) and the European Seismic Code (EC8). It is known that the fundamental period of a structure play a key role in the correct estimation of the spectral acceleration for seismic static analyses and to detect possible resonance phenomena with the foundation soil. Usually, simplified approaches dictate the use of safety factors greater than those related to in depth dynamic linear and nonlinear analyses with the aim to cover any unexpected uncertainties. The fundamental period calculated with the simplified formula given by both NTC 2008 and EC8 is higher than the fundamental period measured on the investigated structures in Italy, Spain and Greece. The consequence is that the spectral acceleration adopted in the seismic static analysis may be significantly different than real spectral acceleration. This approach could produces a decreasing in safety factors obtained using linear seismic static analyses. Based on numerical and experimental results, in order to confirm the results proposed in this work, authors suggest to increase the number of numerical and experimental tests considering also the effects of non-structural components and soil during small, medium and strong motion earthquakes. Acknowledgements This study was partially funded by the Italian Department of Civil Protection within the project DPC-RELUIS 2016 - RS4 ''Seismic observatory of structures and health monitoring'' and by the "Centre of Integrated Geomorphology for the Mediterranean Area - CGIAM" within the Framework Agreement with the University of Basilicata "Study, Research and Experimentation in the Field of Analysis and Monitoring of Seismic Vulnerability of Strategic and Relevant Buildings for the purposes of Civil Protection and Development of Innovative Strategies of Seismic Reinforcement".

Redefining the Practice of Peer Review Through Intelligent Automation Part 1: Creation of a Standardized Methodology and Referenceable Database.

PubMed

Reiner, Bruce I

2017-10-01

Conventional peer review practice is compromised by a number of well-documented biases, which in turn limit standard of care analysis, which is fundamental to determination of medical malpractice. In addition to these intrinsic biases, other existing deficiencies exist in current peer review including the lack of standardization, objectivity, retrospective practice, and automation. An alternative model to address these deficiencies would be one which is completely blinded to the peer reviewer, requires independent reporting from both parties, utilizes automated data mining techniques for neutral and objective report analysis, and provides data reconciliation for resolution of finding-specific report differences. If properly implemented, this peer review model could result in creation of a standardized referenceable peer review database which could further assist in customizable education, technology refinement, and implementation of real-time context and user-specific decision support.

Extended investigation of the twelve-flavor β-function

NASA Astrophysics Data System (ADS)

Fodor, Zoltán; Holland, Kieran; Kuti, Julius; Nógrádi, Dániel; Wong, Chik Him

2018-04-01

We report new results from high precision analysis of an important BSM gauge theory with twelve massless fermion flavors in the fundamental representation of the SU(3) color gauge group. The range of the renormalized gauge coupling is extended from our earlier work [1] to probe the existence of an infrared fixed point (IRFP) in the β-function reported at two different locations, originally in [2] and at a new location in [3]. We find no evidence for the IRFP of the β-function in the extended range of the renormalized gauge coupling, in disagreement with [2,3]. New arguments to guard the existence of the IRFP remain unconvincing [4], including recent claims of an IRFP with ten massless fermion flavors [5,6] which we also rule out. Predictions of the recently completed 5-loop QCD β-function for general flavor number are discussed in this context.

Optimal Portfolio Selection Under Concave Price Impact

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ma Jin, E-mail: jinma@usc.edu; Song Qingshuo, E-mail: songe.qingshuo@cityu.edu.hk; Xu Jing, E-mail: xujing8023@yahoo.com.cn

2013-06-15

In this paper we study an optimal portfolio selection problem under instantaneous price impact. Based on some empirical analysis in the literature, we model such impact as a concave function of the trading size when the trading size is small. The price impact can be thought of as either a liquidity cost or a transaction cost, but the concavity nature of the cost leads to some fundamental difference from those in the existing literature. We show that the problem can be reduced to an impulse control problem, but without fixed cost, and that the value function is a viscosity solutionmore » to a special type of Quasi-Variational Inequality (QVI). We also prove directly (without using the solution to the QVI) that the optimal strategy exists and more importantly, despite the absence of a fixed cost, it is still in a 'piecewise constant' form, reflecting a more practical perspective.« less

DOE Office of Scientific and Technical Information (OSTI.GOV)

Duan, Sisi; Li, Yun; Levitt, Karl N.

Consensus is a fundamental approach to implementing fault-tolerant services through replication where there exists a tradeoff between the cost and the resilience. For instance, Crash Fault Tolerant (CFT) protocols have a low cost but can only handle crash failures while Byzantine Fault Tolerant (BFT) protocols handle arbitrary failures but have a higher cost. Hybrid protocols enjoy the benefits of both high performance without failures and high resiliency under failures by switching among different subprotocols. However, it is challenging to determine which subprotocols should be used. We propose a moving target approach to switch among protocols according to the existing systemmore » and network vulnerability. At the core of our approach is a formalized cost model that evaluates the vulnerability and performance of consensus protocols based on real-time Intrusion Detection System (IDS) signals. Based on the evaluation results, we demonstrate that a safe, cheap, and unpredictable protocol is always used and a high IDS error rate can be tolerated.« less

The Strong Nuclear Force

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lincoln, Don

Scientists are aware of four fundamental forces- gravity, electromagnetism, and the strong and weak nuclear forces. Most people have at least some familiarity with gravity and electromagnetism, but not the other two. How is it that scientists are so certain that two additional forces exist? In this video, Fermilab’s Dr. Don Lincoln explains why scientists are so certain that the strong force exists.

The Strong Nuclear Force

ScienceCinema

Lincoln, Don

2018-01-16

Scientists are aware of four fundamental forces- gravity, electromagnetism, and the strong and weak nuclear forces. Most people have at least some familiarity with gravity and electromagnetism, but not the other two. How is it that scientists are so certain that two additional forces exist? In this video, Fermilab’s Dr. Don Lincoln explains why scientists are so certain that the strong force exists.

Quantum correlation exists in any non-product state

PubMed Central

Guo, Yu; Wu, Shengjun

2014-01-01

Simultaneous existence of correlation in complementary bases is a fundamental feature of quantum correlation, and we show that this characteristic is present in any non-product bipartite state. We propose a measure via mutually unbiased bases to study this feature of quantum correlation, and compare it with other measures of quantum correlation for several families of bipartite states. PMID:25434458

Toward high value sensing: monolayer-protected metal nanoparticles in multivariable gas and vapor sensors.

PubMed

Potyrailo, Radislav A

2017-08-29

For detection of gases and vapors in complex backgrounds, "classic" analytical instruments are an unavoidable alternative to existing sensors. Recently a new generation of sensors, known as multivariable sensors, emerged with a fundamentally different perspective for sensing to eliminate limitations of existing sensors. In multivariable sensors, a sensing material is designed to have diverse responses to different gases and vapors and is coupled to a multivariable transducer that provides independent outputs to recognize these diverse responses. Data analytics tools provide rejection of interferences and multi-analyte quantitation. This review critically analyses advances of multivariable sensors based on ligand-functionalized metal nanoparticles also known as monolayer-protected nanoparticles (MPNs). These MPN sensing materials distinctively stand out from other sensing materials for multivariable sensors due to their diversity of gas- and vapor-response mechanisms as provided by organic and biological ligands, applicability of these sensing materials for broad classes of gas-phase compounds such as condensable vapors and non-condensable gases, and for several principles of signal transduction in multivariable sensors that result in non-resonant and resonant electrical sensors as well as material- and structure-based photonic sensors. Such features should allow MPN multivariable sensors to be an attractive high value addition to existing analytical instrumentation.

[Post-treatment rehabilitation after autologous chondrocyte implantation: State of the art and recommendations of the Clinical Tissue Regeneration Study Group of the German Society for Accident Surgery and the German Society for Orthopedics and Orthopedic Surgery].

PubMed

Pietschmann, M F; Horng, A; Glaser, C; Albrecht, D; Bruns, J; Scheffler, S; Marlovits, S; Angele, P; Aurich, M; Bosch, U; Fritz, J; Frosch, K H; Kolombe, T; Richter, W; Petersen, J P; Nöth, U; Niemeyer, P; Jagodzinsky, M; Kasten, P; Ruhnau, K; Müller, P E

2014-03-01

Over the course of the past two decades autologous chondrocyte implantation (ACI) has become an important surgical technique for treating large cartilage defects. The original method using a periostal flap has been improved by using cell-seeded scaffolds for implantation, the matrix-based autologous chondrocyte implantation (mb-ACI) procedure. Uniform nationwide guidelines for post-ACI rehabilitation do not exist. A survey was conducted among the members of the clinical tissue regeneration study group concerning the current rehabilitation protocols and the members of the study group published recommendations for postoperative rehabilitation and treatment after ACI based on the results of this survey. There was agreement on fundamentals concerning a location-specific rehabilitation protocol (femoral condyle vs. patellofemoral joint). With regard to weight bearing and range of motion a variety of different protocols exist. Similar to this total agreement on the role of magnetic resonance imaging (MRI) for postsurgical care was found but again a great variety of different protocols exist. This manuscript summarizes the recommendations of the members of the German clinical tissue regeneration study group on postsurgical rehabilitation and MRI assessment after ACI (level IVb/EBM).

Differences in Motivations between Fundamental Christians and Atheists on the Reiss Profile of Fundamental Goals and Motivational Sensitivities.

ERIC Educational Resources Information Center

Beasley, Amy; Rowell, Kevin

A study examined differences in motivations between fundamental Christians and atheists on the Reiss Profile of Fundamental Goals and Motivational Sensitivities. Only five of the 15 areas measured by the Reiss Profile were used in the study. The hypothesis was that (within these areas: (1) independence, (2) power, (3) vengeance, (4) status, and…

Telemedicine at sea and onshore: divergences and convergences.

PubMed

Guitton, Matthieu J

2015-01-01

Telemedical Maritime Assistance Service (TMAS) is one of the fundamental components of medical assistance delivery at sea. However, while onshore telemedicine is undergoing a fast growth, these research and clinical investments unfortunately did not yet benefit for telemedicine at sea. While telemedicine aims at providing distant health care, telemedicine at sea and onshore bear major differences, particularly for merchant vessels, and to a lesser extent for passenger vessels, which can be divided between structural differences, differences of practices, and policy differences. Despite the existence of important divergences between telemedicine at sea and telemedicine onshore, these two major branches of distant health care delivery still converge in some respects. Identifying the convergences between telemedicine at sea and telemedicine onshore might contribute to increase and optimise the transfer from research on onshore telemedicine to maritime telemedicine, and to overcome the relatively low amount of research performed on telemedicine at sea compared to its onshore counterpart.

Mixing characterization of highly underexpanded fluid jets with real gas expansion

NASA Astrophysics Data System (ADS)

Förster, Felix J.; Baab, Steffen; Steinhausen, Christoph; Lamanna, Grazia; Ewart, Paul; Weigand, Bernhard

2018-03-01

We report a comprehensive speed of sound database for multi-component mixing of underexpanded fuel jets with real gas expansion. The paper presents several reference test cases with well-defined experimental conditions providing quantitative data for validation of computational simulations. Two injectant fluids, fundamentally different with respect to their critical properties, are brought to supercritical state and discharged into cold nitrogen at different pressures. The database features a wide range of nozzle pressure ratios covering the regimes that are generally classified as highly and extremely highly underexpanded jets. Further variation is introduced by investigating different injection temperatures. Measurements are obtained along the centerline at different axial positions. In addition, an adiabatic mixing model based on non-ideal thermodynamic mixture properties is used to extract mixture compositions from the experimental speed of sound data. The concentration data obtained are complemented by existing experimental data and represented by an empirical fit.

Unification of nonclassicality measures in interferometry

NASA Astrophysics Data System (ADS)

Yuan, Xiao; Zhou, Hongyi; Gu, Mile; Ma, Xiongfeng

2018-01-01

From an operational perspective, nonclassicality characterizes the exotic behavior in a physical process which cannot be explained with Newtonian physics. There are several widely used measures of nonclassicality, including coherence, discord, and entanglement, each proven to be essential resources in particular situations. There exists evidence of fundamental connections among the three measures. However, the sources of nonclassicality are still regarded differently and such connections are yet to be elucidated. Here, we introduce a general framework of defining a unified nonclassicality with an operational motivation founded on the capability of interferometry. Nonclassicality appears differently as coherence, discord, and entanglement in different scenarios with local measurement, weak basis-independent measurement, and strong basis-independent measurement, respectively. Our results elaborate how these three measures are related and how they can be transformed from each other. Experimental schemes are proposed to test the results.

Mechanism and models for zinc metal morphology in alkaline media

NASA Technical Reports Server (NTRS)

May, C. E.; Kautz, H. E.

1981-01-01

Based on experimental observations, a mechanism is presented to explain existence of the different morphologies of electrodeposited zinc in alkaline solution. The high current density dendrites appear to be due to more rapid growth on the nonbasal crystallographic planes than on the basal plane. The low current density moss apparently results from dissolution from the nonbasal planes at low cathodic voltages. Electrochemical models were sought which would produce such a phenomenon. The fundamental plating mechanism alone accounts only for different rates on different planes, not for zinc dissolution from a plane in the cathodic region. Fourteen models were explored; two models were in accord with the proposed mechanism. One involves rapid disproportionation of the zinc +1 species on the nonbasal planes. The other involves a redox reaction (corrosion) between the zinc-zincate and hydrogen-water systems.

Structure and Growth of Hexagonal Boron Nitride on Ir(111).

PubMed

Farwick Zum Hagen, Ferdinand H; Zimmermann, Domenik M; Silva, Caio C; Schlueter, Christoph; Atodiresei, Nicolae; Jolie, Wouter; Martínez-Galera, Antonio J; Dombrowski, Daniela; Schröder, Ulrike A; Will, Moritz; Lazić, Predrag; Caciuc, Vasile; Blügel, Stefan; Lee, Tien-Lin; Michely, Thomas; Busse, Carsten

2016-12-27

Using the X-ray standing wave method, scanning tunneling microscopy, low energy electron diffraction, and density functional theory, we precisely determine the lateral and vertical structure of hexagonal boron nitride on Ir(111). The moiré superstructure leads to a periodic arrangement of strongly chemisorbed valleys in an otherwise rather flat, weakly physisorbed plane. The best commensurate approximation of the moiré unit cell is (12 × 12) boron nitride cells resting on (11 × 11) substrate cells, which is at variance with several earlier studies. We uncover the existence of two fundamentally different mechanisms of layer formation for hexagonal boron nitride, namely, nucleation and growth as opposed to network formation without nucleation. The different pathways are linked to different distributions of rotational domains, and the latter enables selection of a single orientation only.

A Tour Through Shape Dynamic Black Holes

NASA Astrophysics Data System (ADS)

Herczeg, Gabriel

Shape dynamics is a classical theory of gravity which agrees with general relativity in many important cases, but possesses different gauge symmetries and constraints. Rather than spacetime diffeomorphism invariance, shape dynamics takes spatial diffeomorphism invariance and spatial Weyl invariance as the fundamental gauge symmetries associated with the gravitational field. Despite these differences, shape dynamics and general relativity generically predict the same dynamics--there exist gauge-fixings of each theory that ensure agreement with the other. However, these gauge-fixing conditions are not necessarily globally well-defined and it is therefore possible to find solutions of the shape dynamics equations of motion that agree with general relativity on some open neighborhoods, but which have different global structures. In particular, the black hole solutions of the two theories disagree globally. Understanding these novel "shape dynamic black holes" is the primary goal of this thesis.

Distributed magnetic field positioning system using code division multiple access

NASA Technical Reports Server (NTRS)

Prigge, Eric A. (Inventor)

2003-01-01

An apparatus and methods for a magnetic field positioning system use a fundamentally different, and advantageous, signal structure and multiple access method, known as Code Division Multiple Access (CDMA). This signal architecture, when combined with processing methods, leads to advantages over the existing technologies, especially when applied to a system with a large number of magnetic field generators (beacons). Beacons at known positions generate coded magnetic fields, and a magnetic sensor measures a sum field and decomposes it into component fields to determine the sensor position and orientation. The apparatus and methods can have a large `building-sized` coverage area. The system allows for numerous beacons to be distributed throughout an area at a number of different locations. A method to estimate position and attitude, with no prior knowledge, uses dipole fields produced by these beacons in different locations.

Pharmaceutical solvates, hydrates and amorphous forms: A special emphasis on cocrystals.

PubMed

Healy, Anne Marie; Worku, Zelalem Ayenew; Kumar, Dinesh; Madi, Atif M

2017-08-01

Active pharmaceutical ingredients (APIs) may exist in various solid forms, which can lead to differences in the intermolecular interactions, affecting the internal energy and enthalpy, and the degree of disorder, affecting the entropy. Differences in solid forms often lead to differences in thermodynamic parameters and physicochemical properties for example solubility, dissolution rate, stability and mechanical properties of APIs and excipients. Hence, solid forms of APIs play a vital role in drug discovery and development in the context of optimization of bioavailability, filing intellectual property rights and developing suitable manufacturing methods. In this review, the fundamental characteristics and trends observed for pharmaceutical hydrates, solvates and amorphous forms are presented, with special emphasis, due to their relative abundance, on pharmaceutical hydrates with single and two-component (i.e. cocrystal) host molecules. Copyright © 2017 Elsevier B.V. All rights reserved.

Quantum stochastic calculus associated with quadratic quantum noises

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ji, Un Cig, E-mail: uncigji@chungbuk.ac.kr; Sinha, Kalyan B., E-mail: kbs-jaya@yahoo.co.in

2016-02-15

We first study a class of fundamental quantum stochastic processes induced by the generators of a six dimensional non-solvable Lie †-algebra consisting of all linear combinations of the generalized Gross Laplacian and its adjoint, annihilation operator, creation operator, conservation, and time, and then we study the quantum stochastic integrals associated with the class of fundamental quantum stochastic processes, and the quantum Itô formula is revisited. The existence and uniqueness of solution of a quantum stochastic differential equation is proved. The unitarity conditions of solutions of quantum stochastic differential equations associated with the fundamental processes are examined. The quantum stochastic calculusmore » extends the Hudson-Parthasarathy quantum stochastic calculus.« less

Successful rehabilitation program rests on service utilization.

PubMed

Lane, L

1993-07-01

An effective rehabilitation strategy is built upon three fundamentals: translating resident needs into delivered services, managing occupancy and marketing programs, and utilizing existing reimbursement mechanisms to ensure profitability of the venture.

28 CFR 35.150 - Existing facilities.

Code of Federal Regulations, 2010 CFR

2010-07-01

... public entity to take any action that it can demonstrate would result in a fundamental alteration in the... the previous transition plan. (Approved by the Office of Management and Budget under control number...

A formula for successfully competing in non-US health insurance markets.

PubMed

Beichl, Lisa; Gunnery, Lisa; Navarro, José Antonio

2003-01-01

Many insurers in non-US markets are experiencing difficulties in developing managed care strategies to combat increasing medical costs. Some attempts to transport managed care techniques outside of the US have failed. Although it is difficult to determine the exact causes of failure, some common threads exist. When these common characteristics are explored, fundamental building blocks will emerge. When introduced, these fundamentals can lead to increased efficiency, thereby paving the way to successful managed care development in non-US markets.

A new fundamental type of conformational isomerism

NASA Astrophysics Data System (ADS)

Canfield, Peter J.; Blake, Iain M.; Cai, Zheng-Li; Luck, Ian J.; Krausz, Elmars; Kobayashi, Rika; Reimers, Jeffrey R.; Crossley, Maxwell J.

2018-06-01

Isomerism is a fundamental chemical concept, reflecting the fact that the arrangement of atoms in a molecular entity has a profound influence on its chemical and physical properties. Here we describe a previously unclassified fundamental form of conformational isomerism through four resolved stereoisomers of a transoid (BF)O(BF)-quinoxalinoporphyrin. These comprise two pairs of enantiomers that manifest structural relationships not describable within existing IUPAC nomenclature and terminology. They undergo thermal diastereomeric interconversion over a barrier of 104 ± 2 kJ mol-1, which we term `akamptisomerization'. Feasible interconversion processes between conceivable synthesis products and reaction intermediates were mapped out by density functional theory calculations, identifying bond-angle inversion (BAI) at a singly bonded atom as the reaction mechanism. We also introduce the necessary BAI stereodescriptors parvo and amplo. Based on an extended polytope formalism of molecular structure and stereoisomerization, BAI-driven akamptisomerization is shown to be the final fundamental type of conformational isomerization.

IN VITRO STUDIES: WHAT IS THEIR ROLE IN TOXICOLOGY?

EPA Science Inventory

Many epidemiology studies have reported associations between inhaled environmental pollutants, especially particles, and mortality or morbidity. Despite these impressive associations, fundamental uncertainties exist as to the underlying pathophysiological mechanisms responsible f...

Speed and Delay Prediction Models for Planning Applications

DOT National Transportation Integrated Search

1999-01-01

Estimation of vehicle speed and delay is fundamental to many forms of : transportation planning analyses including air quality, long-range travel : forecasting, major investment studies, and congestion management systems. : However, existing planning...

Invariant patterns in crystal lattices: Implications for protein folding algorithms

DOE Office of Scientific and Technical Information (OSTI.GOV)

HART,WILLIAM E.; ISTRAIL,SORIN

2000-06-01

Crystal lattices are infinite periodic graphs that occur naturally in a variety of geometries and which are of fundamental importance in polymer science. Discrete models of protein folding use crystal lattices to define the space of protein conformations. Because various crystal lattices provide discretizations of the same physical phenomenon, it is reasonable to expect that there will exist invariants across lattices related to fundamental properties of the protein folding process. This paper considers whether performance-guaranteed approximability is such an invariant for HP lattice models. The authors define a master approximation algorithm that has provable performance guarantees provided that a specificmore » sublattice exists within a given lattice. They describe a broad class of crystal lattices that are approximable, which further suggests that approximability is a general property of HP lattice models.« less

DOE Office of Scientific and Technical Information (OSTI.GOV)

Carpenter, J.M.

This paper reviews the early history of pulsed spallation neutron source development at Argonne and provides an overview of existing sources world wide. A number of proposals for machines more powerful than currently exist are under development, which are briefly described. The author reviews the status of the Intense Pulsed Neutron Source, its instrumentation, and its user program, and provides a few examples of applications in fundamental condensed matter physics, materials science and technology.

Chemically attached gold nanoparticle-carbon nanotube hybrids for highly sensitive SERS substrate

NASA Astrophysics Data System (ADS)

Beqa, Lule; Singh, Anant Kumar; Fan, Zheng; Senapati, Dulal; Ray, Paresh Chandra

2011-08-01

Surface-enhanced Raman spectroscopy (SERS) has been shown as one of the most powerful analytical tool with high sensitivity. In this manuscript, we report the chemical design of SERS substrate, based on gold nanoparticles of different shapes-decorated with carbon nanotube with an enhancement factor of 7.5 × 1010. Shape dependent result shows that popcorn shape gold nanoparticle decorated SWCNT is the best choice for SERS substrate due to the existence of 'lightning rod effect' through several sharp edges or corners. Our results provide a good approach to develop highly sensitive SERS substrates and can help to improve the fundamental understanding of SERS phenomena.

Considering Risk and Resilience in Decision-Making

NASA Technical Reports Server (NTRS)

Torres-Pomales, Wilfredo

2015-01-01

This paper examines the concepts of decision-making, risk analysis, uncertainty and resilience analysis. The relation between risk, vulnerability, and resilience is analyzed. The paper describes how complexity, uncertainty, and ambiguity are the most critical factors in the definition of the approach and criteria for decision-making. Uncertainty in its various forms is what limits our ability to offer definitive answers to questions about the outcomes of alternatives in a decision-making process. It is shown that, although resilience-informed decision-making would seem fundamentally different from risk-informed decision-making, this is not the case as resilience-analysis can be easily incorporated within existing analytic-deliberative decision-making frameworks.

Feasibility of adapting the fundamentals of laparoscopic surgery trainer box to endoscopic skills training tool.

PubMed

Crespin, Oscar M; Okrainec, Allan; Kwong, Andrea V; Habaz, Ilay; Jimenez, Maria Carolina; Szasz, Peter; Weiss, Ethan; Gonzalez, Cecilia G; Mosko, Jeffrey D; Liu, Louis W C; Swanstrom, Lee L; Perretta, Silvana; Shlomovitz, Eran

2018-06-01

The fundamentals of laparoscopic surgery (FLS) training box is a validated tool, already accessible to surgical trainees to hone their laparoscopic skills. We aim to investigate the feasibility of adapting the FLS box for the practice and assessment of endoscopic skills. This would allow for a highly available, reusable, low-cost, mechanical trainer. The design and development process was based on a user-centered design, which is a combination of the design thinking method and cognitive task analysis. The process comprises four phases: empathy, cognitive, prototyping/adaptation, and end user testing. The underlying idea was to utilize as many of the existing components of FLS training to maintain simplicity and cost effectiveness while allowing for the practice of clinically relevant endoscopic skills. A sample size of 18 participants was calculated to be sufficient to detect performance differences between experts and trainees using a two tailed t test with alpha set at 0.05, standard deviation of 5.5, and a power of 80%. Adaptation to the FLS box included two fundamental attachments: a front panel with an insertion point for an endoscope and a shaft which provides additional support and limits movement of the scope. The panel also allows for mounting of retroflexion tasks. Six endoscopic tasks inspired by FLS were designed (two of which utilize existing FLS components). Pilot testing with 38 participants showed high user's satisfaction and demonstrated that the trainer was robust and reliable. Task performance times was able to discriminate between trainees and experts for all six tasks. A mechanical, reusable, low-cost adaptation of the FLS training box for endoscopic skills is feasible and has high user satisfaction. Preliminary testing shows that the simulator is able to discriminate between trainees and experts. Following further validation, this adaptation may act as a supplement to the FES program.

Exploring the East-West Divide in Prevalence of Affective Disorder: A Case for Cultural Differences in Coping With Negative Emotion.

PubMed

De Vaus, June; Hornsey, Matthew J; Kuppens, Peter; Bastian, Brock

2017-10-01

Lifetime rates of clinical depression and anxiety in the West tend to be approximately 4 to 10 times greater than rates in Asia. In this review, we explore one possible reason for this cross-cultural difference, that Asian cultures think differently about emotion than do Western cultures and that these different systems of thought help explain why negative affect does not escalate into clinical disorder at the same rate. We review research from multiple disciplines-including cross-cultural psychology, social cognition, clinical psychology, and psychiatry-to make the case that the Eastern holistic principles of contradiction (each experience is associated with its opposite), change (the world exists in a state of constant flux), and context (the interconnectedness of all things) fundamentally shape people's experience of emotions in different cultures. We then review evidence for how these cultural differences influence how successfully people use common emotion regulation strategies such as rumination and suppression.

Evidence-based Kernels: Fundamental Units of Behavioral Influence

PubMed Central

Biglan, Anthony

2008-01-01

This paper describes evidence-based kernels, fundamental units of behavioral influence that appear to underlie effective prevention and treatment for children, adults, and families. A kernel is a behavior–influence procedure shown through experimental analysis to affect a specific behavior and that is indivisible in the sense that removing any of its components would render it inert. Existing evidence shows that a variety of kernels can influence behavior in context, and some evidence suggests that frequent use or sufficient use of some kernels may produce longer lasting behavioral shifts. The analysis of kernels could contribute to an empirically based theory of behavioral influence, augment existing prevention or treatment efforts, facilitate the dissemination of effective prevention and treatment practices, clarify the active ingredients in existing interventions, and contribute to efficiently developing interventions that are more effective. Kernels involve one or more of the following mechanisms of behavior influence: reinforcement, altering antecedents, changing verbal relational responding, or changing physiological states directly. The paper describes 52 of these kernels, and details practical, theoretical, and research implications, including calling for a national database of kernels that influence human behavior. PMID:18712600

Dependence of elastic hadron collisions on impact parameter

NASA Astrophysics Data System (ADS)

Procházka, Jiří; Lokajíček, Miloš V.; Kundrát, Vojtěch

2016-05-01

Elastic proton-proton collisions represent probably the greatest ensemble of available measured data, the analysis of which may provide a large amount of new physical results concerning fundamental particles. It is, however, necessary to analyze first some conclusions concerning pp collisions and their interpretations differing fundamentally from our common macroscopic experience. It has been argued, e.g., that elastic hadron collisions have been more central than inelastic ones, even if any explanation of the existence of so different processes, i.e., elastic and inelastic (with hundreds of secondary particles) collisions, under the same conditions has not been given until now. The given conclusion has been based on a greater number of simplifying mathematical assumptions (already done in earlier calculations), without their influence on physical interpretation being analyzed and entitled; the corresponding influence has started to be studied in the approach based on the eikonal model. The possibility of a peripheral interpretation of elastic collisions will be demonstrated and the corresponding results summarized. The arguments will be given on why no preference may be given to the mentioned centrality against the standard peripheral behaviour. The corresponding discussion on the contemporary description of elastic hadronic collision in dependence on the impact parameter will be summarized and the justification of some important assumptions will be considered.

Topological constraints and the existence of force-free fields

NASA Technical Reports Server (NTRS)

Antiochos, S. K.

1986-01-01

A fundamental problem in plasma theory is the question of the existence of MHD equilibria. The issue of topological constraints is of crucial importance for the problem of the existence of equilibria. Heuristic methods are used to discuss the coronal wrapping pattern. It is concluded that for a given set of footpoint positions the wrapping pattern in the corona is completely fixed. The topological constraints are included in the boundary conditions on the Euler potentials and impost no additional restrictions on possible equilibria. Although this does not prove that equilibria always exist, it does show that the force-free problem is not overdetermined and that existence of equilibria is still an open question.

Biodiversity in the cyclic competition system of three species according to the emergence of mutant species

NASA Astrophysics Data System (ADS)

Park, Junpyo

2018-05-01

Understanding mechanisms which promote or hinder existing ecosystems are important issues in ecological sciences. In addition to fundamental interactions such as competition and migration among native species, existing ecosystems can be easily disturbed by external factors, and the emergence of new species may be an example in such cases. The new species which does not exist in a current ecosystem can be regarded as either alien species entered from outside or mutant species born by mutation in existing normal species. Recently, as existing ecosystems are getting influenced by various physical/chemical external factors, mutation due to anthropogenic and environmental factors can occur more frequently and is thus attracting much attention for the maintenance of ecosystems. In this paper, we consider emergences of mutant species among self-competing three species in the cyclic dominance. By defining mutation as the birth of mutant species, we investigate how mutant species can affect biodiversity in the existing ecosystem. Through microscopic and macroscopic approaches, we have found that the society of existing normal species can be disturbed by mutant species either the society is maintained accompanying with the coexistence of all species or jeopardized by occupying of mutant species. Due to the birth of mutant species, the existing society may be more complex by constituting two different groups of normal and mutant species, and our results can be contributed to analyze complex ecosystems of many species. We hope our findings may propose a new insight on mutation in cyclic competition systems of many species.

Manual evaluation of the diaphragm muscle

PubMed Central

Bordoni, Bruno; Marelli, F; Morabito, B; Sacconi, B

2016-01-01

The respiratory diaphragm is the most important muscle for breathing. It contributes to various processes such as expectoration, vomiting, swallowing, urination, and defecation. It facilitates the venous and lymphatic return and helps viscera located above and below the diaphragm to work properly. Its activity is fundamental in the maintenance of posture and body position changes. It can affect the pain perception and emotional state. Many authors reported on diaphragmatic training by using special instruments, whereas only a few studies focused on manual therapy approaches. To the knowledge of the authors, the existing scientific literature does not exhaustively examines the manual evaluation of the diaphragm in its different portions. A complete evaluation of the diaphragm is mandatory for several professional subjects, such as physiotherapists, osteopaths, and chiropractors not only to elaborate a treatment strategy but also to obtain information on the validity of the training performed on the patient. This article aims to describe a strategy of manual evaluation of the diaphragm, with particular attention to anatomical fundamentals, in order to stimulate further research on this less explored field. PMID:27574419

The general theory of blade screws including propellers, fans, helicopter screws, helicoidal pumps, turbo-motors, and different kinds of helicoidal blades

NASA Technical Reports Server (NTRS)

De Bothezat, George

1920-01-01

Report presents a theory which gives a complete picture and an exact quantitative analysis of the whole phenomenon of the working of blade screws, but also unites in a continuous whole the entire scale of states of work conceivable for a blade screw. Chapter 1 is devoted to the establishment of the system of fundamental equations relating to the blade screw. Chapter 2 contains the general discussion of the 16 states of work which may establish themselves for a blade screw. The existence of the vortex ring state and the whirling phenomenon are established. All the fundamental functions which enter the blade-screw theory are submitted to a general analytical discussion. The general outline of the curve of the specific function is examined. Two limited cases of the work of the screw, the screw with a zero constructive pitch and the screw with an infinite constructive pitch, are pointed out. Chapter 3 is devoted to the study of the propulsive screw or propeller. (author)

A comparative study of the vibrational spectra of the anticancer drug melphalan and its fundamental molecules 3-phenylpropionic acid and L-phenylalanine

NASA Astrophysics Data System (ADS)

Badawi, Hassan M.; Khan, Ibrahim

2016-04-01

The structural stability and the vibrational spectra of the anticancer drug melphalan and its parent compounds 3-phenylpropionic acid and L-phenylalanine were investigated by the DFT B3LYP/6-311G** calculations. Melphalan and its fundamental compounds were predicted to exist predominantly in non-planar structures. The vibrational frequencies of the low energy structures of melphalan, 3-phenylpropionic acid, and phenylalanine were computed at the DFT B3LYP level of theory. Complete vibrational assignments of the normal modes of melphalan, 3-phenylpropionic acid, and phenylalanine were provided by combined theoretical and experimental data of the molecules. The experimental infrared spectra of phenylalanine and melphalan show a significantly different pattern of the Cdbnd O stretching mode as compared to those of normal carboxylic acids. A comparison of the 3700-2000 cm-1 infrared spectral region of the three molecules suggests the presence of similar intermolecular H-bonding in their condensed phases. The observed infrared and Raman spectra are consistent with the presence of one predominant melphalan conformation at room temperature.

Stabilization of a finite slice in miscible displacement in homogeneous porous media

NASA Astrophysics Data System (ADS)

Pramanik, Satyajit; Mishra, Manoranjan

2016-11-01

We numerically studied the miscible displacement of a finite slice of variable viscosity and density. The stability of the finite slice depends on different flow parameters, such as displacement velocity U, mobility ratio R , and the density contrast. Series of numerical simulations corresponding to different ordered pair (R, U) in the parameter space, and a given density contrast reveal six different instability regions. We have shown that independent of the width of the slice, there always exists a region of stable displacement, and below a critical value of the slice width, this stable region increases with decreasing slice width. Further we observe that the viscous fingering (buoyancy-induced instability) at the upper interface induces buoyancy-induced instability (viscous fingering) at the lower interface. Besides the fundamental fluid dynamics understanding, our results can be helpful to model CO2 sequestration and chromatographic separation.

The status of the concept of 'phoneme' in psycholinguistics.

PubMed

Uppstad, Per Henning; Tønnessen, Finn Egil

2010-10-01

The notion of the phoneme counts as a break-through of modern theoretical linguistics in the early twentieth century. It paved the way for descriptions of distinctive features at different levels in linguistics. Although it has since then had a turbulent existence across altering theoretical positions, it remains a powerful concept of a fundamental unit in spoken language. At the same time, its conceptual status remains highly unclear. The present article aims to clarify the status of the concept of 'phoneme' in psycholinguistics, based on the scientific concepts of description, understanding and explanation. Theoretical linguistics has provided mainly descriptions. The ideas underlying this article are, first, that these descriptions may not be directly relevant to psycholinguistics and, second, that psycholinguistics in this sense is not a sub-discipline of theoretical linguistics. Rather, these two disciplines operate with different sets of features and with different orientations when it comes to the scientific concepts of description, understanding and explanation.

Self-Euthanasia, the Dutch Experience: In Search for the Meaning of a Good Death or Eu Thanatos.

PubMed

Vink, Ton

2016-11-01

My main purpose in this article is to establish the meaning of a 'good death' when death is self-chosen. I will take as my point of departure the new notion of 'self-euthanasia' and the corresponding practice that has evolved in the Netherlands in recent years. Both physician-euthanasia and self-euthanasia refer to an ideal process of a good death, the first being ultimately the physician's responsibility, while the second is definitely the responsibility of the individual choosing to die. However, if we also accept the existence of a fundamental moral difference between ending another person's life and ending your own life, and if we accept this moral difference to be also relevant to the normatively laden good death, then this difference represents a strong reason for preferring self-euthanasia to physician-euthanasia. © 2016 John Wiley & Sons Ltd.

Interaction of graphite and ablative materials with CO2-laser, carbon-arc, and xenon-arc radiation. M.S. Thesis - George Washington Univ., Washington, D. C.

NASA Technical Reports Server (NTRS)

Brewer, W. D.

1975-01-01

The behavior of graphite and several charring ablators in a variety of high radiative heat flux environments was studied in various radiative environments produced by a CO2 laser and a carbon arc facility. Graphite was also tested in xenon arc radiation. Tests were conducted in air nitrogen, helium, and a mixture of CO2 and nitrogen, simulating the Venus atmosphere. The experimental results are compared with theoretical results obtained with a one dimensional charring ablator analysis and a two dimensional subliming ablator analysis. Photomicroscopy showed no significant differences in appearance or microstructure of the charring ablators or graphite after testing in the three different facilities, indicating that the materials respond fundamentally the same to the radiation of different frequencies. The performance of phenolic nylon and graphite was satisfactorily predicted with existing analyses and published material property data.

Predictive modeling of synergistic effects in nanoscale ion track formation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zarkadoula, Eva; Pakarinen, Olli H.; Xue, Haizhou

Molecular dynamics techniques and the inelastic thermal spike model are used to study the coupled effects of inelastic energy loss due to 21 MeV Ni ion irradiation and pre-existing defects in SrTiO 3. We determine the dependence on pre-existing defect concentration of nanoscale track formation occurring from the synergy between the inelastic energy loss and the pre-existing atomic defects. We show that the nanoscale ion tracks’ size can be controlled by the concentration of pre-existing disorder. This work identifies a major gap in fundamental understanding concerning the role played by defects in electronic energy dissipation and electron–lattice coupling.

Predictive modeling of synergistic effects in nanoscale ion track formation

DOE PAGES

Zarkadoula, Eva; Pakarinen, Olli H.; Xue, Haizhou; ...

2015-08-05

Molecular dynamics techniques and the inelastic thermal spike model are used to study the coupled effects of inelastic energy loss due to 21 MeV Ni ion irradiation and pre-existing defects in SrTiO 3. We determine the dependence on pre-existing defect concentration of nanoscale track formation occurring from the synergy between the inelastic energy loss and the pre-existing atomic defects. We show that the nanoscale ion tracks’ size can be controlled by the concentration of pre-existing disorder. This work identifies a major gap in fundamental understanding concerning the role played by defects in electronic energy dissipation and electron–lattice coupling.

24 CFR 8.24 - Existing housing programs.

Code of Federal Regulations, 2010 CFR

2010-04-01

... recipient to take any action that it can demonstrate would result in a fundamental alteration in the nature... the Office of Management and Budget under control number 2529-0034) [53 FR 20233, June 2, 1988; 53 FR...

Developing a remote practice office.

PubMed

D'Elia, V L

1987-11-01

Remote practice offices (RPOs) offer unique opportunities for hospitals and physicians to increase market share from targeted areas where previously only limited demand existed. This article discusses the benefits and explores the fundamentals of developing a remote practice office.

In search of the origin of mass.

PubMed

Shears, T G; Heinemann, B; Waters, D

2006-12-15

Particle physics explores the structure of matter by studying the behaviour of its most fundamental constituents. Despite the remarkable success of our theories, there remains much that is fundamental but unexplained. One of our most pressing questions concerns the origin of mass. Our favoured theoretical explanation for the existence of mass also predicts the existence of a particle that has never been seen-the Higgs boson. In this review, we survey our knowledge of the Higgs boson and explain why, if the theory is correct, we should expect to make our first observation of the elusive Higgs in the next few years, when a major new particle physics facility starts operating. This will be the most powerful particle accelerator in the world. Although searching for the Higgs boson will be challenging in this environment, we hope that our experimental results will allow us to finally understand the origin of mass and extend our knowledge of the Universe yet further.

Appeals to Autonomy and Obedience: Continuity and Change in Governing Technologies in Danish and Swedish Health Promotion

PubMed Central

VALLGÅRDA, SIGNILD

2011-01-01

The increasingly used concept new public health indicates that a fundamental change has occurred in the goals and methods of disease prevention and health promotion. The change is often said to imply less expert-driven governing of citizens. In this article, governing technologies in the field of public health in Denmark and Sweden are analysed to investigate whether substantial changes have taken place in the governing efforts. In the endeavours unfolded in relation to health examinations for children and pregnant women during the last eighty years, no apparent evidence exists of a significant change in governing technologies. Regulatory, expert-driven and empowering technologies have been used during the whole period; additionally, appeals to autonomy, responsibility and obedience as well as to trust in authorities co-exist throughout the period. The fundamental change is the huge increase in the health authorities’ governing ambitions. PMID:23752863

Realistic clocks, universal decoherence, and the black hole information paradox.

PubMed

Gambini, Rodolfo; Porto, Rafael A; Pullin, Jorge

2004-12-10

Ordinary quantum mechanics is formulated on the basis of the existence of an ideal classical clock external to the system under study. This is clearly an idealization. As emphasized originally by Salecker and Wigner and more recently by others, there exist limits in nature to how "classical" even the best possible clock can be. With realistic clocks, quantum mechanics ceases to be unitary and a fundamental mechanism of decoherence of quantum states arises. We estimate the rate of the universal loss of unitarity using optimal realistic clocks. In particular, we observe that the rate is rapid enough to eliminate the black hole information puzzle: all information is lost through the fundamental decoherence before the black hole can evaporate. This improves on a previous calculation we presented with a suboptimal clock in which only part of the information was lost by the time of evaporation.

Quantum Mechanics: Myths and Facts

NASA Astrophysics Data System (ADS)

Nikolić, Hrvoje

2007-11-01

A common understanding of quantum mechanics (QM) among students and practical users is often plagued by a number of “myths”, that is, widely accepted claims on which there is not really a general consensus among experts in foundations of QM. These myths include wave-particle duality, time-energy uncertainty relation, fundamental randomness, the absence of measurement-independent reality, locality of QM, nonlocality of QM, the existence of well-defined relativistic QM, the claims that quantum field theory (QFT) solves the problems of relativistic QM or that QFT is a theory of particles, as well as myths on black-hole entropy. The fact is that the existence of various theoretical and interpretational ambiguities underlying these myths does not yet allow us to accept them as proven facts. I review the main arguments and counterarguments lying behind these myths and conclude that QM is still a not-yet-completely-understood theory open to further fundamental research.

The death instinct and the mental dimension beyond the pleasure principle in the works of Spielrein and Freud.

PubMed

Caropreso, Fátima

2017-12-01

In 'Destruction as Cause of Come-into-being', Spielrein argues for the need of postulating the existence of a death instinct in mental functioning. The idea that she thus anticipated the concept of death instinct Freud introduced in 1920 is often found in psychoanalytic literature. But the specific meaning of Spielrein's hypothesis is seldom discussed, as well as the extent to which she anticipated Freud's concept. In fact, there are important differences between their views. Besides, a closer analysis of Spielrein's text reveals other ideas that come close to fundamental aspects of Freud's theories from 1920 onwards, particularly the assumption of a more primordial mental functioning than the one regulated by the pleasure principle. But also here there are important differences between the views sustained by both authors. With this in view, the objective of this paper is firstly to discuss some hypotheses formulated by Spielrein in her 1912 work in order to elucidate her concept of death instinct as well as her hypothesis of the existence of a more primitive mental functioning than the one governed by the pleasure principle. Next, the question of the possible similarities and differences with regard to Freud's concepts is also addressed. Copyright © 2017 Institute of Psychoanalysis.

Increasing the utility of regional water table maps: a new method for estimating groundwater recharge

NASA Astrophysics Data System (ADS)

Gilmore, T. E.; Zlotnik, V. A.; Johnson, M.

2017-12-01

Groundwater table elevations are one of the most fundamental measurements used to characterize unconfined aquifers, groundwater flow patterns, and aquifer sustainability over time. In this study, we developed an analytical model that relies on analysis of groundwater elevation contour (equipotential) shape, aquifer transmissivity, and streambed gradient between two parallel, perennial streams. Using two existing regional water table maps, created at different times using different methods, our analysis of groundwater elevation contours, transmissivity and streambed gradient produced groundwater recharge rates (42-218 mm yr-1) that were consistent with previous independent recharge estimates from different methods. The three regions we investigated overly the High Plains Aquifer in Nebraska and included some areas where groundwater is used for irrigation. The three regions ranged from 1,500 to 3,300 km2, with either Sand Hills surficial geology, or Sand Hills transitioning to loess. Based on our results, the approach may be used to increase the value of existing water table maps, and may be useful as a diagnostic tool to evaluate the quality of groundwater table maps, identify areas in need of detailed aquifer characterization and expansion of groundwater monitoring networks, and/or as a first approximation before investing in more complex approaches to groundwater recharge estimation.

TOWARD A THEORY OF SUSTAINABLE SYSTEMS

EPA Science Inventory

While there is tremendous interest in sustainability, a fundamental theory of sustainability does not exist. We present our efforts at constructing such a theory using Physics, Information Theory, Economics and Ecology. We discuss the state of complex sustainable systems that i...

Older people, personal hygiene, and skin care.

PubMed

Cowdell, Fiona

2011-01-01

Skin health is essential for well being in older people. Personal hygiene is fundamental to skin health, but a lack of evidence exists about effective practices. An evidence base, disseminated through nursing education and patient health promotion, must be developed.

Cooperative expression of atomic chirality in inorganic nanostructures.

PubMed

Wang, Peng-Peng; Yu, Shang-Jie; Govorov, Alexander O; Ouyang, Min

2017-02-02

Cooperative chirality phenomena extensively exist in biomolecular and organic systems via intra- and inter-molecular interactions, but study of inorganic materials has been lacking. Here we report, experimentally and theoretically, cooperative chirality in colloidal cinnabar mercury sulfide nanocrystals that originates from chirality interplay between the crystallographic lattice and geometric morphology at different length scales. A two-step synthetic scheme is developed to allow control of critical parameters of these two types of handedness, resulting in different chiral interplays expressed as observables through materials engineering. Furthermore, we adopt an electromagnetic model with the finite element method to elucidate cooperative chirality in inorganic systems, showing excellent agreement with experimental results. Our study enables an emerging class of nanostructures with tailored cooperative chirality that is vital for fundamental understanding of nanoscale chirality as well as technology applications based on new chiroptical building blocks.

Cooperative expression of atomic chirality in inorganic nanostructures

PubMed Central

Wang, Peng-peng; Yu, Shang-Jie; Govorov, Alexander O; Ouyang, Min

2017-01-01

Cooperative chirality phenomena extensively exist in biomolecular and organic systems via intra- and inter-molecular interactions, but study of inorganic materials has been lacking. Here we report, experimentally and theoretically, cooperative chirality in colloidal cinnabar mercury sulfide nanocrystals that originates from chirality interplay between the crystallographic lattice and geometric morphology at different length scales. A two-step synthetic scheme is developed to allow control of critical parameters of these two types of handedness, resulting in different chiral interplays expressed as observables through materials engineering. Furthermore, we adopt an electromagnetic model with the finite element method to elucidate cooperative chirality in inorganic systems, showing excellent agreement with experimental results. Our study enables an emerging class of nanostructures with tailored cooperative chirality that is vital for fundamental understanding of nanoscale chirality as well as technology applications based on new chiroptical building blocks. PMID:28148957

When Medicine Meets Engineering—Paradigm Shifts in Diagnostics and Therapeutics

PubMed Central

Wang, Hann; Silva, Aleidy; Ho, Chih-Ming

2013-01-01

During the last two decades, the manufacturing techniques of microfluidics-based devices have been phenomenally advanced, offering unlimited potential for bio-medical technologies. However, the direct applications of these technologies toward diagnostics and therapeutics are still far from maturity. The present challenges lay at the interfaces between the engineering systems and the biocomplex systems. A precisely designed engineering system with narrow dynamic range is hard to seamlessly integrate with the adaptive biological system in order to achieve the design goals. These differences remain as the roadblock between two fundamentally non-compatible systems. This paper will not extensively review the existing microfluidic sensors and actuators; rather, we will discuss the sources of the gaps for integration. We will also introduce system interface technologies for bridging the differences to lead toward paradigm shifts in diagnostics and therapeutics. PMID:26835672

An experimental study of nonlinear dynamic system identification

NASA Technical Reports Server (NTRS)

Stry, Greselda I.; Mook, D. Joseph

1990-01-01

A technique for robust identification of nonlinear dynamic systems is developed and illustrated using both simulations and analog experiments. The technique is based on the Minimum Model Error optimal estimation approach. A detailed literature review is included in which fundamental differences between the current approach and previous work is described. The most significant feature of the current work is the ability to identify nonlinear dynamic systems without prior assumptions regarding the form of the nonlinearities, in constrast to existing nonlinear identification approaches which usually require detailed assumptions of the nonlinearities. The example illustrations indicate that the method is robust with respect to prior ignorance of the model, and with respect to measurement noise, measurement frequency, and measurement record length.

Anonymity in Voting Revisited

NASA Astrophysics Data System (ADS)

Jonker, Hugo; Pieters, Wolter

According to international law, anonymity of the voter is a fundamental precondition for democratic elections. In electronic voting, several aspects of voter anonymity have been identified. In this paper, we re-examine anonymity with respect to voting, and generalise existing notions of anonymity in e-voting. First, we identify and categorise the types of attack that can be a threat to anonymity of the voter, including different types of vote buying and coercion. This analysis leads to a categorisation of anonymity in voting in terms of a) the strength of the anonymity achieved and b) the extent of interaction between voter and attacker. Some of the combinations, including weak and strong receipt-freeness, are formalised in epistemic logic.

“Docs 'n Drugs” - A System for Case-Oriented and Web-based Training in Medicine

PubMed Central

Martens, A.; Bernauer, J.

1999-01-01

The tutoring process of conventional case-oriented medical training systems can be characterised as either guided or unguided. In contrast to that, the aim of the system “Docs'n Drugs” is to distinguish between different levels of guidance. The author can realise the tutoring case either as a guided, a half guided or a unguided tutoring process. The system architecture distinguishes between an authoring system and a tutoring system. Fundaments of these are the tutoring process model and the case-based knowledge model. This structure allows the reuse of elements of existing tutoring cases. The tutoring cases can be realised in German and English.

Bacterial Actins? An Evolutionary Perspective

NASA Technical Reports Server (NTRS)

Doolittle, Russell F.; York, Amanda L.

2003-01-01

According to the conventional wisdom, the existence of a cytoskeleton in eukaryotes and its absence in prokaryotes constitute a fundamental divide between the two domains of life. An integral part of the dogma is that a cytoskeleton enabled an early eukaryote to feed upon prokaryotes, a consequence of which was the occasional endosymbiosis and the eventual evolution of organelles. Two recent papers present compelling evidence that actin, one of the principal components of a cytoskeleton, has a homolog in Bacteria that behaves in many ways like eukaryotic actin. Sequence comparisons reveml that eukaryotic actin and the bacterial homolog (mreB protein), unlike many other proteins common to eukaryotes and Bacteria, have very different and more highly extended evolutionary histories.

Review of phase measuring deflectometry

DOE PAGES

Huang, Lei; Idir, Mourad; Zuo, Chao; ...

2018-04-07

As a low cost, full-field three-dimensional shape measurement technique with high dynamic range, Phase Measuring Deflectometry (PMD) has been studied and improved to be a simple and effective manner to inspect specular reflecting surfaces. In this review, the fundamental principle and the basic concepts of PMD technique are introduced and followed by a brief overview of its key developments since it was first proposed. In addition, the similarities and differences compared with other related techniques are discussed to highlight the distinguishing features of the PMD technique. In conclusion, we will address the major challenges, the existing solutions and the remainingmore » limitations in this technique to provide some suggestions for potential future investigations.« less

A Different Point of View towards GRB 031203

NASA Technical Reports Server (NTRS)

Ramirez-Ruiz, E.; Granot, J.; Kouveliotou, C.; Woosley, S. E.; Patel, S. K.; Mazzali, P. A.

2004-01-01

One of the most fundamental characteristics of any explosion is its energy, yet despite lively debates, the gamma-ray burst (GRB) community has still to reach a consensus on whether GRBs are standard bombs with a total energy in their relativistic ejecta approximately 10(exp 51) ergs, or a broad range of phenomena with energies varying by many orders of magnitude. While low energy GRBs may well exist, we show here that observations of GRB 031203, do not require a sub-energetic nature for that event. In fact, contrary to previous claims, the data are more consistent with a typical, powerful GRB seen at an angle of about twice the opening angle of the central jet.

Monitoring of changes in cluster structures in water under AC magnetic field

NASA Astrophysics Data System (ADS)

Usanov, A. D.; Ulyanov, S. S.; Ilyukhina, N. S.; Usanov, D. A.

2016-01-01

A fundamental possibility of visualizing cluster structures formed in distilled water by an optical method based on the analysis of dynamic speckle structures is demonstrated. It is shown for the first time that, in contrast to the existing concepts, water clusters can be rather large (up to 200 -m in size), and their lifetime is several tens of seconds. These clusters are found to have an internal spatially inhomogeneous structure, constantly changing in time. The properties of magnetized and non-magnetized water are found to differ significantly. In particular, the number of clusters formed in magnetized water is several times larger than that formed in the same volume of non-magnetized water.

Black hole demography at the dawn of gravitational-wave astronomy: state-of-the art and future perspectives

NASA Astrophysics Data System (ADS)

Mapelli, Michela

2018-02-01

The first four LIGO detections have confirmed the existence of massive black holes (BHs), with mass 30-40 M⊙. Such BHs might originate from massive metal-poor stars (Z < 0:3 Z⊙) or from gravitational instabilities in the early Universe. The formation channels of merging BHs are still poorly constrained. The measure of mass, spin and redshift distribution of merging BHs will give us fundamental clues to distinguish between different models. In parallel, a better understanding of several astrophysical processes (e.g. common envelope, core-collapse SNe, and dynamical evolution of BHs) is decisive, to shed light on the formation channels of merging BHs.

Direct observation of attractive skyrmions and skyrmion clusters in the cubic helimagnet Cu2OSeO3

NASA Astrophysics Data System (ADS)

Loudon, J. C.; Leonov, A. O.; Bogdanov, A. N.; Hatnean, M. Ciomaga; Balakrishnan, G.

2018-04-01

We report the discovery of attractive magnetic skyrmions and their clusters in noncentrosymmetric ferromagnets. These three-dimensional solitons have been predicted to exist in the cone phase of chiral ferromagnets [J. Phys: Condens. Matter 28, 35LT01 (2016), 10.1088/0953-8984/28/35/35LT01] and are fundamentally different from the more common repulsive axisymmetric skyrmions that occur in the magnetically saturated state. We present real-space images of these skyrmion clusters in thin (˜70 nm) single-crystal samples of Cu2OSeO3 taken using transmission electron microscopy and develop a phenomenological theory describing this type of skyrmion.

GPU-accelerated computation of electron transfer.

PubMed

Höfinger, Siegfried; Acocella, Angela; Pop, Sergiu C; Narumi, Tetsu; Yasuoka, Kenji; Beu, Titus; Zerbetto, Francesco

2012-11-05

Electron transfer is a fundamental process that can be studied with the help of computer simulation. The underlying quantum mechanical description renders the problem a computationally intensive application. In this study, we probe the graphics processing unit (GPU) for suitability to this type of problem. Time-critical components are identified via profiling of an existing implementation and several different variants are tested involving the GPU at increasing levels of abstraction. A publicly available library supporting basic linear algebra operations on the GPU turns out to accelerate the computation approximately 50-fold with minor dependence on actual problem size. The performance gain does not compromise numerical accuracy and is of significant value for practical purposes. Copyright © 2012 Wiley Periodicals, Inc.

Spectrum-averaged Harmonic Path (SHAPA) algorithm for non-contact vital sign monitoring with ultra-wideband (UWB) radar.

PubMed

Van Nguyen; Javaid, Abdul Q; Weitnauer, Mary Ann

2014-01-01

We introduce the Spectrum-averaged Harmonic Path (SHAPA) algorithm for estimation of heart rate (HR) and respiration rate (RR) with Impulse Radio Ultrawideband (IR-UWB) radar. Periodic movement of human torso caused by respiration and heart beat induces fundamental frequencies and their harmonics at the respiration and heart rates. IR-UWB enables capture of these spectral components and frequency domain processing enables a low cost implementation. Most existing methods of identifying the fundamental component either in frequency or time domain to estimate the HR and/or RR lead to significant error if the fundamental is distorted or cancelled by interference. The SHAPA algorithm (1) takes advantage of the HR harmonics, where there is less interference, and (2) exploits the information in previous spectra to achieve more reliable and robust estimation of the fundamental frequency in the spectrum under consideration. Example experimental results for HR estimation demonstrate how our algorithm eliminates errors caused by interference and produces 16% to 60% more valid estimates.

Fundamental movement skills and habitual physical activity in young children.

PubMed

Fisher, Abigail; Reilly, John J; Kelly, Louise A; Montgomery, Colette; Williamson, Avril; Paton, James Y; Grant, Stan

2005-04-01

To test for relationships between objectively measured habitual physical activity and fundamental movement skills in a relatively large and representative sample of preschool children. Physical activity was measured over 6 d using the Computer Science and Applications (CSA) accelerometer in 394 boys and girls (mean age 4.2, SD 0.5 yr). Children were scored on 15 fundamental movement skills, based on the Movement Assessment Battery, by a single observer. Total physical activity (r=0.10, P<0.05) and percent time spent in moderate to vigorous physical activity (MVPA) (r=0.18, P<0.001) were significantly correlated with total movement skills score. Time spent in light-intensity physical activity was not significantly correlated with motor skills score (r=0.02, P>0.05). In this sample and setting, fundamental movement skills were significantly associated with habitual physical activity, but the association between the two variables was weak. The present study questions whether the widely assumed relationships between motor skills and habitual physical activity actually exist in young children.

Where (who) are collectives in collectivism? Toward conceptual clarification of individualism and collectivism.

PubMed

Brewer, Marilynn B; Chen, Ya-Ru

2007-01-01

In psychological research on cultural differences, the distinction between individualism and collectivism has received the lion's share of attention as a fundamental dimension of cultural variation. In recent years, however, these constructs have been criticized as being ill-defined and "a catchall" to represent all forms of cultural differences. The authors argue that there is a conceptual confusion about the meaning of ingroups that constitute the target of collectivism. Collectives are rarely referred to in existing measures to assess collectivism. Instead, networks of interpersonal relationships dominate the operational definition of "ingroups" in these measures. Results from a content analysis of existing scales support this observation. To clarify and expand the individualism-collectivism distinction, a theoretical framework is proposed that draws on M. B. Brewer and G. Gardner's (1996) conceptualization of individual, relational, and collective selves and their manifestation in self-representations, beliefs, and values. Analyses of data from past studies provide preliminary support for this conceptual model. The authors propose that this new theoretical framework will contribute conceptual clarity to interpretation of past research on individualism and collectivism and guide future research on these important constructs. ((c) 2007 APA, all rights reserved).

Theory of winds in late-type evolved and pre-main-sequence stars

NASA Technical Reports Server (NTRS)

Macgregor, K. B.

1983-01-01

Recent observational results confirm that many of the physical processes which are known to occur in the Sun also occur among late-type stars in general. One such process is the continuous loss of mass from a star in the form of a wind. There now exists an abundance of either direct or circumstantial evidence which suggests that most (if not all) stars in the cool portion of the HR diagram possess winds. An attempt is made to assess the current state of theoretical understanding of mass loss from two distinctly different classes of late-type stars: the post-main-sequence giant/supergiant stars and the pre-main-sequence T Tauri stars. Toward this end, the observationally inferred properties of the wind associated with each of the two stellar classes under consideration are summarized and compared against the predictions of existing theoretical models. Although considerable progress has been made in attempting to identify the mechanisms responsible for mass loss from cool stars, many fundamental problems remain to be solved.

Droplet Microarray Based on Superhydrophobic-Superhydrophilic Patterns for Single Cell Analysis.

PubMed

Jogia, Gabriella E; Tronser, Tina; Popova, Anna A; Levkin, Pavel A

2016-12-09

Single-cell analysis provides fundamental information on individual cell response to different environmental cues and is a growing interest in cancer and stem cell research. However, current existing methods are still facing challenges in performing such analysis in a high-throughput manner whilst being cost-effective. Here we established the Droplet Microarray (DMA) as a miniaturized screening platform for high-throughput single-cell analysis. Using the method of limited dilution and varying cell density and seeding time, we optimized the distribution of single cells on the DMA. We established culturing conditions for single cells in individual droplets on DMA obtaining the survival of nearly 100% of single cells and doubling time of single cells comparable with that of cells cultured in bulk cell population using conventional methods. Our results demonstrate that the DMA is a suitable platform for single-cell analysis, which carries a number of advantages compared with existing technologies allowing for treatment, staining and spot-to-spot analysis of single cells over time using conventional analysis methods such as microscopy.

The SHiP physics program

NASA Astrophysics Data System (ADS)

De Lellis, Giovanni

2018-05-01

The discovery of the Higgs boson has fully confirmed the Standard Model of particles and fields. Nevertheless, there are still fundamental phenomena, like the existence of dark matter and the baryon asymmetry of the Universe, which deserve an explanation that could come from the discovery of new particles. The SHiP experiment at CERN meant to search for very weakly coupled particles in the few GeV mass domain has been recently proposed. The existence of such particles, foreseen in different theoretical models beyond the Standard Model, is largely unexplored. A beam dump facility using high intensity 400 GeV protons is a copious source of such unknown particles in the GeV mass range. The beam dump is also a copious source of neutrinos and in particular it is an ideal source of tau neutrinos, the less known particle in the Standard Model. Indeed, tau anti-neutrinos have not been directly observed so far. We report the physics potential of such an experiment including the tau neutrino magnetic moment.

An ontology of scientific experiments

PubMed Central

Soldatova, Larisa N; King, Ross D

2006-01-01

The formal description of experiments for efficient analysis, annotation and sharing of results is a fundamental part of the practice of science. Ontologies are required to achieve this objective. A few subject-specific ontologies of experiments currently exist. However, despite the unity of scientific experimentation, no general ontology of experiments exists. We propose the ontology EXPO to meet this need. EXPO links the SUMO (the Suggested Upper Merged Ontology) with subject-specific ontologies of experiments by formalizing the generic concepts of experimental design, methodology and results representation. EXPO is expressed in the W3C standard ontology language OWL-DL. We demonstrate the utility of EXPO and its ability to describe different experimental domains, by applying it to two experiments: one in high-energy physics and the other in phylogenetics. The use of EXPO made the goals and structure of these experiments more explicit, revealed ambiguities, and highlighted an unexpected similarity. We conclude that, EXPO is of general value in describing experiments and a step towards the formalization of science. PMID:17015305

Comprehensive characterisation of sewage sludge for thermochemical conversion processes - Based on Singapore survey.

PubMed

Chan, Wei Ping; Wang, Jing-Yuan

2016-08-01

Recently, sludge attracted great interest as a potential feedstock in thermochemical conversion processes. However, compositions and thermal degradation behaviours of sludge were highly complex and distinctive compared to other traditional feedstock led to a need of fundamental research on sludge. Comprehensive characterisation of sludge specifically for thermochemical conversion was carried out for all existing Water Reclamation Plants in Singapore. In total, 14 sludge samples collected based on the type, plant, and batch categorisation. Existing characterisation methods for physical and chemical properties were analysed and reviewed using the collected samples. Qualitative similarities and quantitative variations of different sludge samples were identified and discussed. Oxidation of inorganic in sludge during ash forming analysis found to be causing significant deviations on proximate and ultimate analysis. Therefore, alternative parameters and comparison basis including Fixed Residues (FR), Inorganic Matters (IM) and Total Inorganics (TI) were proposed for better understanding on the thermochemical characteristics of sludge. Copyright © 2016 Elsevier Ltd. All rights reserved.

Neutrino Oscillations at Proton Accelerators

NASA Astrophysics Data System (ADS)

Michael, Douglas

2002-12-01

Data from many different experiments have started to build a first glimpse of the phenomenology associated with neutrino oscillations. Results on atmospheric and solar neutrinos are particularly clear while a third result from LSND suggests a possibly very complex oscillation phenomenology. As impressive as the results from current experiments are, it is clear that we are just getting started on a long-term experimental program to understand neutrino masses, mixings and the physics which produce them. A number of exciting fundamental physics possibilities exist, including that neutrino oscillations could demonstrate CP or CPT violation and could be tied to exotic high-energy phenomena including strings and extra dimensions. A complete exploration of oscillation phenomena demands many experiments, including those possible using neutrino beams produced at high energy proton accelerators. Most existing neutrino experiments are statistics limited even though they use gigantic detectors. High intensity proton beams are essential for producing the intense neutrino beams which we need for next generation neutrino oscillation experiments.

A Conceptual Approach to the Problem of Action-Angle Variables

NASA Astrophysics Data System (ADS)

Zung, Nguyen Tien

2018-02-01

In this paper we develop a general conceptual approach to the problem of existence of action-angle variables for dynamical systems, which establishes and uses the fundamental conservation property of associated torus actions: anything which is preserved by the system is also preserved by the associated torus actions. This approach allows us to obtain, among other things: (a) the shortest and most easy-to-understand conceptual proof of the classical Arnold-Liouville-Mineur theorem; (b) basically all known results in the literature about the existence of action-angle variables in various contexts can be recovered in a unifying way, with simple proofs, using our approach; (c) new results on action-angle variables in many different contexts, including systems on contact manifolds, systems on presymplectic and Dirac manifolds, action-angle variables near singularities, stochastic systems, and so on. Even when there are no natural action variables, our approach still leads to useful normal forms for dynamical systems, which are not necessarily integrable.

One- and two-dimensional gap solitons and dynamics in the PT-symmetric lattice potential and spatially-periodic momentum modulation

NASA Astrophysics Data System (ADS)

Chen, Yong; Yan, Zhenya; Li, Xin

2018-02-01

The influence of spatially-periodic momentum modulation on beam dynamics in parity-time (PT) symmetric optical lattice is systematically investigated in the one- and two-dimensional nonlinear Schrödinger equations. In the linear regime, we demonstrate that the momentum modulation can alter the first and second PT thresholds of the classical lattice, periodically or regularly change the shapes of the band structure, rotate and split the diffraction patterns of beams leading to multiple refraction and emissions. In the Kerr-nonlinear regime for one-dimension (1D) case, a large family of fundamental solitons within the semi-infinite gap can be found to be stable, even beyond the second PT threshold; it is shown that the momentum modulation can shrink the existing range of fundamental solitons and not change their stability. For two-dimension (2D) case, most solitons with higher intensities are relatively unstable in their existing regions which are narrower than those in 1D case, but we also find stable fundamental solitons corroborated by linear stability analysis and direct beam propagation. More importantly, the momentum modulation can also utterly change the direction of the transverse power flow and control the energy exchange among gain or loss regions.

Clifford Algebra Implying Three Fermion Generations Revisited

NASA Astrophysics Data System (ADS)

Krolikowski, Wojciech

2002-09-01

The author's idea of algebraic compositeness of fundamental particles, allowing to understand the existence in Nature of three fermion generations, is revisited. It is based on two postulates. Primo, for all fundamental particles of matter the Dirac square-root procedure √ {p2} → {Γ }(N)p works, leading to a sequence N = 1,2,3, ... of Dirac-type equations, where four Dirac-type matrices {Γ }(N)μ are embedded into a Clifford algebra via a Jacobi definition introducing four ``centre-of-mass'' and (N-1)× four ``relative'' Dirac-type matrices. These define one ``centre-of-mass'' and (N-1) ``relative'' Dirac bispinor indices. Secundo, the ``centre-of-mass'' Dirac bispinor index is coupled to the Standard Model gauge fields, while (N-1) ``relative'' Dirac bispinor indices are all free indistinguishable physical objects obeying Fermi statistics along with the Pauli principle which requires the full antisymmetry with respect to ``relative'' Dirac indices. This allows only for three Dirac-type equations with N = 1,3,5 in the case of N odd, and two with N = 2,4 in the case of N even. The first of these results implies unavoidably the existence of three and only three generations of fundamental fermions, namely leptons and quarks, as labelled by the Standard Model signature. At the end, a comment is added on the possible shape of Dirac 3x3 mass matrices for four sorts of spin-1/2 fundamental fermions appearing in three generations. For charged leptons a prediction is mτ = 1776.80 MeV, when the input of experimental me and mμ is used.

Elastic Instability of Slender Rods in Steady Shear Flow Yields Positive First Normal Stress Differences

NASA Astrophysics Data System (ADS)

Becker, Leif E.; Shelley, Michael J.

2000-11-01

First normal stress differences in shear flow are a fundamental property of Non-Newtonian fluids. Experiments involving dilute suspensions of slender fibers exhibit a sharp transition to non-zero normal stress differences beyond a critical shear rate, but existing continuum theories for rigid rods predict neither this transition nor the corresponding magnitude of this effect. We present the first conclusive evidence that elastic instabilities are predominantly responsible for observed deviations from the dilute suspension theory of rigid rods. Our analysis is based on slender body theory and the equilibrium equations of elastica. A straight slender body executing its Jeffery orbit in Couette flow is subject to axial fluid forcing, alternating between compression and tension. We present a stability analysis showing that elastic instabilities are possible for strong flows. Simulations give the fully non-linear evolution of this shape instability, and show that flexibility of the fibers alone is sufficient to cause both shear-thinning and significant first normal stress differences.

The SHiP project at CERN

NASA Astrophysics Data System (ADS)

De Lellis, G.; SHiP Collaboration

2016-07-01

The discovery of the Higgs boson has fully confirmed the Standard Model of particles and fields. Nevertheless, there are still fundamental phenomena, like the existence of dark matter and the baryon asymmetry, which deserve an explanation that could come from the discovery of new particles. Searches for new physics with accelerators are performed at the LHC, looking for high massive particles coupled to matter with ordinary strength. A new experimental facility at CERN meant to search for very weakly coupled particles in the few GeV mass domain has been recently proposed. The existence of such particles, foreseen in different theoretical models beyond the Standard Model, is largely unexplored. A beam dump facility using 400 GeV protons is a copious factory of charmed hadrons and could be used to probe the existence of such particles. The beam dump is also a copious source of neutrinos and in particular it is an ideal source of tau neutrinos, the less known particle in the Standard Model. Indeed, tau anti-neutrinos have not been directly observed so far. We report the physics potential of such an experiment. Resistive Plate Chambers could play a role in the SHiP detector.

DO INTERMEDIATE-MASS BLACK HOLES EXIST IN GLOBULAR CLUSTERS?

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sun, Mou-Yuan; Jin, Ya-Ling; Gu, Wei-Min

2013-10-20

The existence of intermediate-mass black holes (IMBHs) in globular clusters (GCs) remains a crucial problem. Searching for IMBHs in GCs reveals a discrepancy between radio observations and dynamical modelings: the upper mass limits constrained by radio observations are systematically lower than that of dynamical modelings. One possibility for such a discrepancy is that, as we suggest in this work, there exist outflows in accretion flows. Our results indicate that, for most sources, current radio observations cannot rule out the possibility that IMBHs may exist in GCs. In addition, we adopt an M-dot -L{sub R} relation to revisit this issue, whichmore » confirms the results obtained by the fundamental plane relation.« less

Disciplining Qualitative Research

ERIC Educational Resources Information Center

Denzin, Norman K.; Lincoln, Yvonna S.; Giardina, Michael D.

2006-01-01

Qualitative research exists in a time of global uncertainty. Around the world, governments are attempting to regulate scientific inquiry by defining what counts as "good" science. These regulatory activities raise fundamental, philosophical epistemological, political and pedagogical issues for scholarship and freedom of speech in the…

Commercial aviation : factors affecting efforts to improve air service at small community airports

DOT National Transportation Integrated Search

2003-01-01

The nations small communities face a range of fundamental economic : challenges in obtaining and retaining the commercial airline service they : desire or making their existing service more attractive to potential : passengers. The smallest of the...

TOWARD A THEORY OF SUSTAINABLE SYSTEMS

EPA Science Inventory

While there is tremendous interest in the topic of sustainability, a fundamental theory of sustainability does not exist. We present our efforts at constructing such a theory starting with Information Theory and ecological models. We discuss the state of complex sustainable syste...

Impressed sources and fields in the volume-integral-equation formulation of electromagnetic scattering by a finite object: A tutorial

NASA Astrophysics Data System (ADS)

Mishchenko, Michael I.; Yurkin, Maxim A.

2018-07-01

Although free space cannot generate electromagnetic waves, the majority of existing accounts of frequency-domain electromagnetic scattering by particles and particle groups are based on the postulate of existence of an impressed incident field, usually in the form of a plane wave. In this tutorial we discuss how to account for the actual existence of impressed source currents rather than impressed incident fields. Specifically, we outline a self-consistent theoretical formalism describing electromagnetic scattering by an arbitrary finite object in the presence of arbitrarily distributed impressed currents, some of which can be far removed from the object and some can reside in its vicinity, including inside the object. To make the resulting formalism applicable to a wide range of scattering-object morphologies, we use the framework of the volume integral equation formulation of electromagnetic scattering, couple it with the notion of the transition operator, and exploit the fundamental symmetry property of this operator. Among novel results, this tutorial includes a streamlined proof of fundamental symmetry (reciprocity) relations, a simplified derivation of the Foldy equations, and an explicit analytical expression for the transition operator of a multi-component scattering object.

Terminology Guideline for Classifying Offshore Wind Energy Resources

DOE Office of Scientific and Technical Information (OSTI.GOV)

Beiter, Philipp; Musial, Walt

The purpose of this guideline is to establish a clear and consistent vocabulary for conveying offshore wind resource potential and to interpret this vocabulary in terms that are familiar to the oil and gas (O&G) industry. This involves clarifying and refining existing definitions of offshore wind energy resource classes. The terminology developed in this guideline represents one of several possible sets of vocabulary that may differ with respect to their purpose, data availability, and comprehensiveness. It was customized to correspond with established offshore wind practices and existing renewable energy industry terminology (e.g. DOE 2013, Brown et al. 2015) while conformingmore » to established fossil resource classification as best as possible. The developers of the guideline recognize the fundamental differences that exist between fossil and renewable energy resources with respect to availability, accessibility, lifetime, and quality. Any quantitative comparison between fossil and renewable energy resources, including offshore wind, is therefore limited. For instance, O&G resources are finite and there may be significant uncertainty associated with the amount of the resource. In contrast, aboveground renewable resources, such as offshore wind, do not generally deplete over time but can vary significantly subhourly, daily, seasonally, and annually. The intent of this guideline is to make these differences transparent and develop an offshore wind resource classification that conforms to established fossil resource classifications where possible. This guideline also provides methods to quantitatively compare certain offshore wind energy resources to O&G resource classes for specific applications. Finally, this guideline identifies areas where analogies to established O&G terminology may be inappropriate or subject to misinterpretation.« less

Critical Conditions for Liquid Chromatography of Statistical Copolymers: Functionality Type and Composition Distribution Characterization by UP-LCCC/ESI-MS.

PubMed

Epping, Ruben; Panne, Ulrich; Falkenhagen, Jana

2017-02-07

Statistical ethylene oxide (EO) and propylene oxide (PO) copolymers of different monomer compositions and different average molar masses additionally containing two kinds of end groups (FTD) were investigated by ultra high pressure liquid chromatography under critical conditions (UP-LCCC) combined with electrospray ionization time-of flight mass spectrometry (ESI-TOF-MS). Theoretical predictions of the existence of a critical adsorption point (CPA) for statistical copolymers with a given chemical and sequence distribution1 could be studied and confirmed. A fundamentally new approach to determine these critical conditions in a copolymer, alongside the inevitable chemical composition distribution (CCD), with mass spectrometric detection, is described. The shift of the critical eluent composition with the monomer composition of the polymers was determined. Due to the broad molar mass distribution (MMD) and the presumed existence of different end group functionalities as well as monomer sequence distribution (MSD), gradient separation only by CCD was not possible. Therefore, isocratic separation conditions at the CPA of definite CCD fractions were developed. Although the various present distributions partly superimposed the separation process, the goal of separation by end group functionality was still achieved on the basis of the additional dimension of ESI-TOF-MS. The existence of HO-H besides the desired allylO-H end group functionalities was confirmed and their amount estimated. Furthermore, indications for a MSD were found by UPLC/MS/MS measurements. This approach offers for the first time the possibility to obtain a fingerprint of a broad distributed statistical copolymer including MMD, FTD, CCD, and MSD.

Fundamental Neutron Physics: Theory and Analysis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gudkov, Vladimir

The goal of the proposal was to study the possibility of searching for manifestations of new physics beyond the Standard model in fundamental neutron physics experiments. This involves detailed theoretical analyses of parity- and time reversal invariance-violating processes in neutron-induced reactions, properties of neutron β-decay, and the precise description of properties of neutron interactions with nuclei. To describe neutron-nuclear interactions, we use both the effective field theory approach and the theory of nuclear reaction with phenomenological nucleon potentials for the systematic description of parity- and time reversal-violating effects in the consistent way. A major emphasis of our research during themore » funding period has been the study of parity violation (PV) and time reversal invariance violation (TRIV) in few-body systems. We studied PV effects in non-elastic processes in three-nucleon system using both ”DDH-like” and effective field theory (EFT) approaches. The wave functions were obtained by solving three-body Faddeev equations in configuration space for a number of realistic strong potentials. The observed model dependence for the DDH approach indicates intrinsic difficulty in the description of nuclear PV effects, and it could be the reason for the observed discrepancies in the nuclear PV data analysis. It shows that the DDH approach could be a reasonable approach for analysis of PV effects only if exactly the same strong and weak potentials are used in calculating all PV observables in all nuclei. However, the existing calculations of nuclear PV effects were performed using different potentials; therefore, strictly speaking, one cannot compare the existing results of these calculations among themselves.« less

STANDING SHOCK INSTABILITY IN ADVECTION-DOMINATED ACCRETION FLOWS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Le, Truong; Wood, Kent S.; Wolff, Michael T.

2016-03-10

Depending on the values of the energy and angular momentum per unit mass in the gas supplied at large radii, inviscid advection-dominated accretion flows can display velocity profiles with either preshock deceleration or preshock acceleration. Nakayama has shown that these two types of flow configurations are expected to have different stability properties. By employing the Chevalier and Imamura linearization method and the Nakayama instability boundary conditions, we discover that there are regions of parameter space where disks/shocks with outflows can be stable or unstable. In regions of instability, we find that preshock deceleration is always unstable to the zeroth mode withmore » zero frequency of oscillation, but is always stable to the fundamental mode and overtones. Furthermore, we also find that preshock acceleration is always unstable to the zeroth mode and that the fundamental mode and overtones become increasingly less stable as the shock location moves away from the horizon when the disk half-height expands above ∼12 gravitational radii at the shock radius. In regions of stability, we demonstrate the zeroth mode to be stable for the velocity profiles that exhibit preshock acceleration and deceleration. Moreover, for models that are linearly unstable, our model suggests the possible existence of quasi-periodic oscillations (QPOs) with ratios 2:3 and 3:5. These ratios are believed to occur in stellar and supermassive black hole candidates, for example, in GRS 1915+105 and Sgr A*, respectively. We expect that similar QPO ratios also exist in regions of stable shocks.« less

Metal losses in pyrometallurgical operations - A review.

PubMed

Bellemans, Inge; De Wilde, Evelien; Moelans, Nele; Verbeken, Kim

2018-05-01

Nowadays, a higher demand on a lot of metals exists, but the quantity and purity of the ores decreases. The amount of scrap, on the other hand, increases and thus, recycling becomes more important. Besides recycling, it is also necessary to improve and optimize existing processes in extractive and recycling metallurgy. One of the main difficulties of the overall-plant recovery are metal losses in slags, in both primary and secondary metal production. In general, an increased understanding of the fundamental mechanisms governing these losses could help further improve production efficiencies. This review aims to summarize and evaluate the current scientific knowledge concerning metal losses and pinpoints the knowledge gaps. First, the industrial importance and impact of metal losses in slags will be illustrated by several examples from both ferrous and non-ferrous industries. Throughout the remainder of this review, the main focus will be put on the particular issues in copper industry. In a second section, the different types of metal losses in slags will be discussed. Generally, metal losses in slags can be subdivided into two types: chemical losses and physical losses. The fundamental insights concerning the responsible mechanisms will be discussed for each type. Subsequently, an overview of the most frequently used techniques for research investigations of the losses will be given. In a fourth section, a more detailed overview will be given on the post-processing treatment of metal-containing slags, i.e. performing slag cleaning operations. The most frequently applied methods will be discussed. Copyright © 2017 Elsevier B.V. All rights reserved.

Molecular structure, electronic properties, NLO, NBO analysis and spectroscopic characterization of Gabapentin with experimental (FT-IR and FT-Raman) techniques and quantum chemical calculations

NASA Astrophysics Data System (ADS)

Sinha, Leena; Karabacak, Mehmet; Narayan, V.; Cinar, Mehmet; Prasad, Onkar

2013-05-01

Gabapentin (GP), structurally related to the neurotransmitter GABA (gamma-aminobutyric acid), mimics the activity of GABA and is also widely used in neurology for the treatment of peripheral neuropathic pain. It exists in zwitterionic form in solid state. The present communication deals with the quantum chemical calculations of energies, geometrical structure and vibrational wavenumbers of GP using density functional (DFT/B3LYP) method with 6-311++G(d,p) basis set. In view of the fact that amino acids exist as zwitterions as well as in the neutral form depending on the environment (solvent, pH, etc.), molecular properties of both the zwitterionic and neutral form of GP have been analyzed. The fundamental vibrational wavenumbers as well as their intensities were calculated and compared with experimental FT-IR and FT-Raman spectra. The fundamental assignments were done on the basis of the total energy distribution (TED) of the vibrational modes, calculated with scaled quantum mechanical (SQM) method. The electric dipole moment, polarizability and the first hyperpolarizability values of the GP have been calculated at the same level of theory and basis set. The nonlinear optical (NLO) behavior of zwitterionic and neutral form has been compared. Stability of the molecule arising from hyper-conjugative interactions and charge delocalization has been analyzed using natural bond orbital analysis. Ultraviolet-visible (UV-Vis) spectrum of the title molecule has also been calculated using TD-DFT method. The thermodynamic properties of both the zwitterionic and neutral form of GP at different temperatures have been calculated.

Feasibility study of the application of existing techniques to remotely monitor hydrochloric acid in the atmosphere

NASA Technical Reports Server (NTRS)

Zwick, H.; Ward, V.; Beaudette, L.

1973-01-01

A critical evaluation of existing optical remote sensors for HCl vapor detection in solid propellant rocket plumes is presented. The P branch of the fundamental vibration-rotation band was selected as the most promising spectral feature to sense. A computation of transmittance for HCl vapor, an estimation of interferent spectra, the application of these spectra to computer modelled remote sensors, and a trade-off study for instrument recommendation are also included.

Fluvial geomorphology on Earth-like planetary surfaces: A review.

PubMed

Baker, Victor R; Hamilton, Christopher W; Burr, Devon M; Gulick, Virginia C; Komatsu, Goro; Luo, Wei; Rice, James W; Rodriguez, J A P

2015-09-15

Morphological evidence for ancient channelized flows (fluvial and fluvial-like landforms) exists on the surfaces of all of the inner planets and on some of the satellites of the Solar System. In some cases, the relevant fluid flows are related to a planetary evolution that involves the global cycling of a volatile component (water for Earth and Mars; methane for Saturn's moon Titan). In other cases, as on Mercury, Venus, Earth's moon, and Jupiter's moon Io, the flows were of highly fluid lava. The discovery, in 1972, of what are now known to be fluvial channels and valleys on Mars sparked a major controversy over the role of water in shaping the surface of that planet. The recognition of the fluvial character of these features has opened unresolved fundamental questions about the geological history of water on Mars, including the presence of an ancient ocean and the operation of a hydrological cycle during the earliest phases of planetary history. Other fundamental questions posed by fluvial and fluvial-like features on planetary bodies include the possible erosive action of large-scale outpourings of very fluid lavas, such as those that may have produced the remarkable canali forms on Venus; the ability of exotic fluids, such as methane, to create fluvial-like landforms, as observed on Saturn's moon, Titan; and the nature of sedimentation and erosion under different conditions of planetary surface gravity. Planetary fluvial geomorphology also illustrates fundamental epistemological and methodological issues, including the role of analogy in geomorphological/geological inquiry.

Transgender Phonosurgery: A Systematic Review and Meta-analysis.

PubMed

Song, Tara Elena; Jiang, Nancy

2017-05-01

Objectives Different surgical techniques have been described in the literature to increase vocal pitch. The purpose of this study is to systematically review these surgeries and perform a meta-analysis to determine which technique increases pitch the most. Data Sources CINAHL, Cochrane, Embase, Medline, PubMed, and Science Direct. Review Methods A systematic review and meta-analysis of the literature was performed using the CINAHL, Cochrane, Embase, Medline, PubMed, and Science Direct databases. Studies were eligible for inclusion if they evaluated pitch-elevating phonosurgical techniques in live humans and performed pre- and postoperative acoustic analysis. Data were gathered regarding surgical technique, pre- and postoperative fundamental frequencies, perioperative care measures, and complications. Results Twenty-nine studies were identified. After applying inclusion and exclusion criteria, a total of 13 studies were included in the meta-analysis. Mechanisms of pitch elevation included increasing vocal cord tension (cricothyroid approximation), shortening the vocal cord length (cold knife glottoplasty, laser-shortening glottoplasty), and decreasing mass (laser reduction glottoplasty). The most common interventions were shortening techniques and cricothyroid approximation (6 studies each). The largest increase in fundamental frequency was seen with techniques that shortened the vocal cords. Preoperative speech therapy, postoperative voice rest, and reporting of patient satisfaction were inconsistent. Many of the studies were limited by low power and short length of follow-up. Conclusions Multiple techniques for elevation of vocal pitch exist, but vocal cord shortening procedures appear to result in the largest increase in fundamental frequency.

Goal-Directed Visual Processing Differentially Impacts Human Ventral and Dorsal Visual Representations

PubMed Central

2017-01-01

Recent studies have challenged the ventral/“what” and dorsal/“where” two-visual-processing-pathway view by showing the existence of “what” and “where” information in both pathways. Is the two-pathway distinction still valid? Here, we examined how goal-directed visual information processing may differentially impact visual representations in these two pathways. Using fMRI and multivariate pattern analysis, in three experiments on human participants (57% females), by manipulating whether color or shape was task-relevant and how they were conjoined, we examined shape-based object category decoding in occipitotemporal and parietal regions. We found that object category representations in all the regions examined were influenced by whether or not object shape was task-relevant. This task effect, however, tended to decrease as task-relevant and irrelevant features were more integrated, reflecting the well-known object-based feature encoding. Interestingly, task relevance played a relatively minor role in driving the representational structures of early visual and ventral object regions. They were driven predominantly by variations in object shapes. In contrast, the effect of task was much greater in dorsal than ventral regions, with object category and task relevance both contributing significantly to the representational structures of the dorsal regions. These results showed that, whereas visual representations in the ventral pathway are more invariant and reflect “what an object is,” those in the dorsal pathway are more adaptive and reflect “what we do with it.” Thus, despite the existence of “what” and “where” information in both visual processing pathways, the two pathways may still differ fundamentally in their roles in visual information representation. SIGNIFICANCE STATEMENT Visual information is thought to be processed in two distinctive pathways: the ventral pathway that processes “what” an object is and the dorsal pathway that processes “where” it is located. This view has been challenged by recent studies revealing the existence of “what” and “where” information in both pathways. Here, we found that goal-directed visual information processing differentially modulates shape-based object category representations in the two pathways. Whereas ventral representations are more invariant to the demand of the task, reflecting what an object is, dorsal representations are more adaptive, reflecting what we do with the object. Thus, despite the existence of “what” and “where” information in both pathways, visual representations may still differ fundamentally in the two pathways. PMID:28821655

A SCIENTIFIC AND TECHNOLOGICAL FRAMEWORK FOR ENVIRONMENTAL DECISION MAKING

EPA Science Inventory

There are significant scientific and technological challenges to managing natural resources. Data needs are cited as an obvious limitation, but there exist more fundamental scientific issues. What is still needed is a method of comparing management strategies based on projected i...

SPECIATION OF ARSENIC IN SULFIDIC SOLUTIONS USING X-RAY ABSORPTION SPECTROSCOPY

EPA Science Inventory

The fate of arsenic in the environment is fundamentally linked to its speciation. Arsenic in aerobic environments is predominantly arsenate, however under reducing conditions arsenite species dominate. In sulfidic environments, thioarsenic species are known to exist and play key...

Update on SU(2) gauge theory with NF = 2 fundamental flavours.

NASA Astrophysics Data System (ADS)

Drach, Vincent; Janowski, Tadeusz; Pica, Claudio

2018-03-01

We present a non perturbative study of SU(2) gauge theory with two fundamental Dirac flavours. This theory provides a minimal template which is ideal for a wide class of Standard Model extensions featuring novel strong dynamics, such as a minimal realization of composite Higgs models. We present an update on the status of the meson spectrum and decay constants based on increased statistics on our existing ensembles and the inclusion of new ensembles with lighter pion masses, resulting in a more reliable chiral extrapolation. Preprint: CP3-Origins-2017-048 DNRF90

The Higgs mechanism and the origin of mass

NASA Astrophysics Data System (ADS)

Djouadi, Abdelhak

2012-06-01

The Higgs mechanism plays a key role in the physics of elementary particles: in the context of the Standard Model, the theory which describes in a unified framework the electromagnetic, weak and strong nuclear interactions, it allows for the generation of particle masses while preserving the fundamental symmetries of the theory. This mechanism predicts the existence of a new type of particle, the scalar Higgs boson, with unique characteristics. The detection of this particle and the study of its fundamental properties is a major goal of high-energy particle colliders, such as the CERN Large Hadron Collider or LHC.

The Higgs Mechanism and the Orogin of Mass

NASA Astrophysics Data System (ADS)

Djouadi, Abdelhak

The Higgs mechanism plays a key role in the physics of elementary particles: in the context of the Standard Model, the theory which, describes in a unified framework the electromagnetic, weak, and strong nuclear interactions, it allows for the generation of particle masses while preserving the fundamental symmetries of the theory. This mechanism predicts the existence of a new type of particle, the scalar Higgs boson, with unique characteristics. The detection of this particle and the study of its fundamental properties is a major goal of high-energy particle colliders, such as the CERN Large Hadron Collider or LHC.

Skill-Based and Planned Active Play Versus Free-Play Effects on Fundamental Movement Skills in Preschoolers.

PubMed

Roach, Lindsay; Keats, Melanie

2018-01-01

Fundamental movement skill interventions are important for promoting physical activity, but the optimal intervention model for preschool children remains unclear. We compared two 8-week interventions, a structured skill-station and a planned active play approach, to a free-play control condition on pre- and postintervention fundamental movement skills. We also collected data regarding program attendance and perceived enjoyment. We found a significant interaction effect between intervention type and time. A Tukey honest significant difference analysis supported a positive intervention effect showing a significant difference between both interventions and the free-play control condition. There was a significant between-group difference in group attendance such that mean attendance was higher for both the free-play and planned active play groups relative to the structured skill-based approach. There were no differences in attendance between free-play and planned active play groups, and there were no differences in enjoyment ratings between the two intervention groups. In sum, while both interventions led to improved fundamental movement skills, the active play approach offered several logistical advantages. Although these findings should be replicated, they can guide feasible and sustainable fundamental movement skill programs within day care settings.

Development of Junior High School Students' Fundamental Movement Skills and Physical Activity in a Naturalistic Physical Education Setting

ERIC Educational Resources Information Center

Kalaja, Sami Pekka; Jaakkola, Timo Tapio; Liukkonen, Jarmo Olavi; Digelidis, Nikolaos

2012-01-01

Background: There is evidence showing that fundamental movement skills and physical activity are related with each other. The ability to perform a variety of fundamental movement skills increases the likelihood of children participating in different physical activities throughout their lives. However, no fundamental movement skill interventions…

The Role for an Evaluator: A Fundamental Issue for Evaluation of Education and Social Programs

ERIC Educational Resources Information Center

Luo, Heng

2010-01-01

This paper discusses one of the fundamental issues in education and social program evaluation: the proper role for an evaluator. Based on respective and comparative analysis of five theorists' positions on this fundamental issue, this paper reveals how different perspectives on other fundamental issues in evaluation such as value, methods, use and…

Complexity of spatiotemporal traffic phenomena in flow of identical drivers: Explanation based on fundamental hypothesis of three-phase theory

NASA Astrophysics Data System (ADS)

Kerner, Boris S.

2012-03-01

Based on numerical simulations of a stochastic three-phase traffic flow model, we reveal the physics of the fundamental hypothesis of three-phase theory that, in contrast with a fundamental diagram of classical traffic flow theories, postulates the existence of a two-dimensional (2D) region of steady states of synchronized flow where a driver makes an arbitrary choice of a space gap (time headway) to the preceding vehicle. We find that macroscopic and microscopic spatiotemporal effects of the entire complexity of traffic congestion observed up to now in real measured traffic data can be explained by simulations of traffic flow consisting of identical drivers and vehicles, if a microscopic model used in these simulations incorporates the fundamental hypothesis of three-phase theory. It is shown that the driver's choice of space gaps within the 2D region of synchronized flow associated with the fundamental hypothesis of three-phase theory can qualitatively change types of congested patterns that can emerge at a highway bottleneck. In particular, if drivers choose long enough spaces gaps associated with the fundamental hypothesis, then general patterns, which consist of synchronized flow and wide moving jams, do not emerge independent of the flow rates and bottleneck characteristics: Even at a heavy bottleneck leading to a very low speed within congested patterns, only synchronized flow patterns occur in which no wide moving jams emerge spontaneously.

Complexity of spatiotemporal traffic phenomena in flow of identical drivers: explanation based on fundamental hypothesis of three-phase theory.

PubMed

Kerner, Boris S

2012-03-01

Based on numerical simulations of a stochastic three-phase traffic flow model, we reveal the physics of the fundamental hypothesis of three-phase theory that, in contrast with a fundamental diagram of classical traffic flow theories, postulates the existence of a two-dimensional (2D) region of steady states of synchronized flow where a driver makes an arbitrary choice of a space gap (time headway) to the preceding vehicle. We find that macroscopic and microscopic spatiotemporal effects of the entire complexity of traffic congestion observed up to now in real measured traffic data can be explained by simulations of traffic flow consisting of identical drivers and vehicles, if a microscopic model used in these simulations incorporates the fundamental hypothesis of three-phase theory. It is shown that the driver's choice of space gaps within the 2D region of synchronized flow associated with the fundamental hypothesis of three-phase theory can qualitatively change types of congested patterns that can emerge at a highway bottleneck. In particular, if drivers choose long enough spaces gaps associated with the fundamental hypothesis, then general patterns, which consist of synchronized flow and wide moving jams, do not emerge independent of the flow rates and bottleneck characteristics: Even at a heavy bottleneck leading to a very low speed within congested patterns, only synchronized flow patterns occur in which no wide moving jams emerge spontaneously.

Relation between nonlocal surface and bulk dark solitons

NASA Astrophysics Data System (ADS)

Gao, Xinghui; Zhang, Chengyun; Wang, Qing

2018-06-01

We investigate the existence and stability of nonlocal surface dark solitons at the interface formed by a nonlocal nonlinear self-defocusing medium and a linear medium. We find that nonlocal fundamental surface dark solitons are always stable in their entire existence domain, while high-order surface dark solitons are oscillatory stable. Comparing with nonlocal bulk dark solitons in amplitude and boundary conditions, nonlocal surface dark solitons can be regarded as the half of the corresponding bulk dark solitons with antisymmetrical amplitude distribution.

ONTIC: A Knowledge Representation System for Mathematics

DTIC Science & Technology

1987-01-01

rrrPrL rr.t - ~ jr V 1.2. O.NTIC ASA FORMAL LANGUAGE 11 (IS zr) :I. (EXISTS-SOME r) (EXISTS ((xI 71) (U2 T2 ) ... ) ( li . X2, -.) . (FORALL ((xl 71) (x2...language. Jonathan Rees spent j.. about a month defining various mathematical concepts in Ontic. Starting with onlv the fundamental notions described...novelty of the Ontic system lies in the way that the above four inference mechanisms are brought together. Ontic integrates constraint prop- agation

Defining and Measuring Psychomotor Performance

ERIC Educational Resources Information Center

Autio, Ossi

2007-01-01

Psychomotor performance is fundamental to human existence. It is important in many real world activities and nowadays psychomotor tests are used in several fields of industry, army, and medical sciences in employee selection. This article tries to define psychomotor activity by introducing some psychomotor theories. Furthermore the…

The Modern View of Nature's Building Blocks.

ERIC Educational Resources Information Center

Akyeampong, D. A.

1985-01-01

Explains current knowledge about the makeup of matter at the microscopic (and even more infinitesimal) levels, accentuating the role of accelerators in the process and considering whether more fundamental particles may exist. Classification of subatomic particles, hadrons, quarks, and gluons are among the areas examined. (JN)

Measuring Environmental Health Perception among College Students

ERIC Educational Resources Information Center

Ratnapradipa, Dhitinut; Brown, Stephen L.; Middleton, Wendi K.; Wodika, Alicia B.

2011-01-01

One's knowledge, perception, and attitude are fundamental in determining how one behaves regarding environmental hazards. While science has made great strides in promoting environmental health, threats still exist, largely due to individual actions in response to potential health hazards. Undergraduate students (n = 395) enrolled in an…

Knowledge and Human Values: A Genealogy of Nihilism.

ERIC Educational Resources Information Center

Dreyfus, Hubert L.

1981-01-01

Nihilism is the fundamental movement in the history of the West. Materialism is a symptom of nihilism. Materialism is the view that all meaning has gone from the cosmos, nature, and culture. Values are objective, explicit options which imply the existence of choice. (JN)

Fundamental awareness: A framework for integrating science, philosophy and metaphysics

PubMed Central

Theise, Neil D.; Kafatos, Menas C.

2016-01-01

ABSTRACT The ontologic framework of Fundamental Awareness proposed here assumes that non-dual Awareness is foundational to the universe, not arising from the interactions or structures of higher level phenomena. The framework allows comparison and integration of views from the three investigative domains concerned with understanding the nature of consciousness: science, philosophy, and metaphysics. In this framework, Awareness is the underlying reality, not reducible to anything else. Awareness and existence are the same. As such, the universe is non-material, self-organizing throughout, a holarchy of complementary, process driven, recursive interactions. The universe is both its own first observer and subject. Considering the world to be non-material and comprised, a priori, of Awareness is to privilege information over materiality, action over agency and to understand that qualia are not a “hard problem,” but the foundational elements of all existence. These views fully reflect main stream Western philosophical traditions, insights from culturally diverse contemplative and mystical traditions, and are in keeping with current scientific thinking, expressible mathematically. PMID:27489576

Fundamental awareness: A framework for integrating science, philosophy and metaphysics.

PubMed

Theise, Neil D; Kafatos, Menas C

2016-01-01

The ontologic framework of Fundamental Awareness proposed here assumes that non-dual Awareness is foundational to the universe, not arising from the interactions or structures of higher level phenomena. The framework allows comparison and integration of views from the three investigative domains concerned with understanding the nature of consciousness: science, philosophy, and metaphysics. In this framework, Awareness is the underlying reality, not reducible to anything else. Awareness and existence are the same. As such, the universe is non-material, self-organizing throughout, a holarchy of complementary, process driven, recursive interactions. The universe is both its own first observer and subject. Considering the world to be non-material and comprised, a priori, of Awareness is to privilege information over materiality, action over agency and to understand that qualia are not a "hard problem," but the foundational elements of all existence. These views fully reflect main stream Western philosophical traditions, insights from culturally diverse contemplative and mystical traditions, and are in keeping with current scientific thinking, expressible mathematically.

Blue 450nm high power semiconductor continuous wave laser bars exceeding rollover output power of 80W

NASA Astrophysics Data System (ADS)

König, H.; Lell, A.; Stojetz, B.; Ali, M.; Eichler, C.; Peter, M.; Löffler, A.; Strauss, U.; Baumann, M.; Balck, A.; Malchus, J.; Krause, V.

2018-02-01

Industrial material processing like cutting or welding of metals is rather energy efficient using direct diode or diode pumped solid state lasers. However, many applications cannot be addressed by established infrared laser technology due to fundamental material properties of the workpiece: For example materials like copper or gold have too low absorption in the near infrared wavelength range to be processed efficiently by use of existing high power laser systems. The huge interest to enable high power kW systems with more suitable wavelengths in the blue spectral range triggered the German funded research project 'BLAULAS': Therein the feasibility and capability of CW operating high power laser bars based on the GaN material system was investigated by Osram and Laserline. High performance bars were enabled by defeating fundamental challenges like material quality as well as the chip processes, both of which differ significantly from well-known IR laser bars. The research samples were assembled on actively cooled heat sinks with hard solder technology. For the first time an output power of 98W per bar at 60A drive current was achieved. Conversion efficiency as high as 46% at 50W output power was demonstrated.

Checks and balances? DNA replication and the cell cycle in Plasmodium.

PubMed

Matthews, Holly; Duffy, Craig W; Merrick, Catherine J

2018-03-27

It is over 100 years since the life-cycle of the malaria parasite Plasmodium was discovered, yet its intricacies remain incompletely understood - a knowledge gap that may prove crucial for our efforts to control the disease. Phenotypic screens have partially filled the void in the antimalarial drug market, but as compound libraries eventually become exhausted, new medicines will only come from directed drug development based on a better understanding of fundamental parasite biology. This review focusses on the unusual cell cycles of Plasmodium, which may present a rich source of novel drug targets as well as a topic of fundamental biological interest. Plasmodium does not grow by conventional binary fission, but rather by several syncytial modes of replication including schizogony and sporogony. Here, we collate what is known about the various cell cycle events and their regulators throughout the Plasmodium life-cycle, highlighting the differences between Plasmodium, model organisms and other apicomplexan parasites and identifying areas where further study is required. The possibility of DNA replication and the cell cycle as a drug target is also explored. Finally the use of existing tools, emerging technologies, their limitations and future directions to elucidate the peculiarities of the Plasmodium cell cycle are discussed.

Impact of information cost and switching of trading strategies in an artificial stock market

NASA Astrophysics Data System (ADS)

Liu, Yi-Fang; Zhang, Wei; Xu, Chao; Vitting Andersen, Jørgen; Xu, Hai-Chuan

2014-08-01

This paper studies the switching of trading strategies and its effect on the market volatility in a continuous double auction market. We describe the behavior when some uninformed agents, who we call switchers, decide whether or not to pay for information before they trade. By paying for the information they behave as informed traders. First we verify that our model is able to reproduce some of the stylized facts in real financial markets. Next we consider the relationship between switching and the market volatility under different structures of investors. We find that there exists a positive relationship between the market volatility and the percentage of switchers. We therefore conclude that the switchers are a destabilizing factor in the market. However, for a given fixed percentage of switchers, the proportion of switchers that decide to buy information at a given moment of time is negatively related to the current market volatility. In other words, if more agents pay for information to know the fundamental value at some time, the market volatility will be lower. This is because the market price is closer to the fundamental value due to information diffusion between switchers.

Differentiating snail intermediate hosts of Schistosoma spp. using molecular approaches: fundamental to successful integrated control mechanism in Africa.

PubMed

Abe, Eniola Michael; Guan, Wei; Guo, Yun-Hai; Kassegne, Kokouvi; Qin, Zhi-Qiang; Xu, Jing; Chen, Jun-Hu; Ekpo, Uwem Friday; Li, Shi-Zhu; Zhou, Xiao-Nong

2018-03-26

Snail intermediate hosts play active roles in the transmission of snail-borne trematode infections in Africa. A good knowledge of snail-borne diseases epidemiology particularly snail intermediate host populations would provide the necessary impetus to complementing existing control strategy. This review highlights the importance of molecular approaches in differentiating snail hosts population structure and the need to provide adequate information on snail host populations by updating snail hosts genome database for Africa, in order to equip different stakeholders with adequate information on the ecology of snail intermediate hosts and their roles in the transmission of different diseases. Also, we identify the gaps and areas where there is need for urgent intervention to facilitate effective integrated control of schistosomiasis and other snail-borne trematode infections. Prioritizing snail studies, especially snail differentiation using molecular tools will boost disease surveillance and also enhance efficient schistosomaisis control programme in Africa.

Highly efficient frequency conversion with bandwidth compression of quantum light

PubMed Central

Allgaier, Markus; Ansari, Vahid; Sansoni, Linda; Eigner, Christof; Quiring, Viktor; Ricken, Raimund; Harder, Georg; Brecht, Benjamin; Silberhorn, Christine

2017-01-01

Hybrid quantum networks rely on efficient interfacing of dissimilar quantum nodes, as elements based on parametric downconversion sources, quantum dots, colour centres or atoms are fundamentally different in their frequencies and bandwidths. Although pulse manipulation has been demonstrated in very different systems, to date no interface exists that provides both an efficient bandwidth compression and a substantial frequency translation at the same time. Here we demonstrate an engineered sum-frequency-conversion process in lithium niobate that achieves both goals. We convert pure photons at telecom wavelengths to the visible range while compressing the bandwidth by a factor of 7.47 under preservation of non-classical photon-number statistics. We achieve internal conversion efficiencies of 61.5%, significantly outperforming spectral filtering for bandwidth compression. Our system thus makes the connection between previously incompatible quantum systems as a step towards usable quantum networks. PMID:28134242

The hallmarks of premalignant conditions: a molecular basis for cancer prevention.

PubMed

Ryan, Bríd M; Faupel-Badger, Jessica M

2016-02-01

The hallmarks of premalignant lesions were first described in the 1970s, a time when relatively little was known about the molecular underpinnings of cancer. Yet it was clear there must be opportunities to intervene early in carcinogenesis. A vast array of molecular information has since been uncovered, with much of this stemming from studies of existing cancer or cancer models. Here, examples of how an understanding of cancer biology has informed cancer prevention studies are highlighted and emerging areas that may have implications for the field of cancer prevention research are described. A note of caution accompanies these examples, in that while there are similarities, there are also fundamental differences between the biology of premalignant lesions or premalignant conditions and invasive cancer. These differences must be kept in mind, and indeed leveraged, when exploring potential cancer prevention measures. Published by Elsevier Inc.

Research of Characteristics of the Low Voltage Power Line in Underground Coal Mine

NASA Astrophysics Data System (ADS)

Wei, Shaoliang; Qin, Shiqun; Gao, Wenchang; Cheng, Fengyu; Cao, Zhongyue

The power line communications (PLCs) can count on existing electrical connections reaching each corner in the locations where such applications are required, so signal transmission over power lines is nowadays gaining more and more interest for applications like internet. The research of characteristics of the low voltage power line is the fundamental and importance task. This work presents a device to test the characteristics of the low voltage power line. The low voltage power line channel characteristics overground and the channel characteristics underground were tested in using this device. Experiments show that, the characteristics are different between the PLCs channel underground coal mine and the PLC channel overground. Different technology should be adopted to structure the PLCs channel model underground coal mine and transmit high speed digital signal. But how to use the technology better to the high-speed digital communication under coal mine is worth of further studying.

Deconvoluting physical and chemical heat: Temperature and spiciness influence flavor differently.

PubMed

Kapaun, Camille L; Dando, Robin

2017-03-01

Flavor is an essential, rich and rewarding part of human life. We refer to both physical and chemical heat in similar terms; elevated temperature and capsaicin are both termed hot. Both influence our perception of flavor, however little research exists into the possibly divergent effect of chemical and physical heat on flavor. A human sensory panel was recruited to determine the equivalent level of capsaicin to match the heat of several physical temperatures. In a subsequent session, the intensities of multiple concentrations of tastant solutions were scaled by the same panel. Finally, panelists evaluated tastants plus equivalent chemical or physical "heat". All basic tastes aside from umami were influenced by heat, capsaicin, or both. Interestingly, capsaicin blocked bitter taste input much more powerfully than elevated temperature. This suggests that despite converging percepts, chemical and physical heat have a fundamentally different effect on the perception of flavor. Copyright © 2016 Elsevier Inc. All rights reserved.

Investigation of the ion beam emission from a pulsed power plasma device

NASA Astrophysics Data System (ADS)

Henríquez, A.; Bhuyan, H.; Favre, M.; Retamal, M. J.; Volkmann, U.; Wyndham, E.; Chuaqui, H.

2014-05-01

Plasma Focus (PF) devices are well known as ion beam sources with characteristic energy among the hundreds of keV to tens of MeV. The information on ion beam energy, ion distribution and composition is essential from the viewpoint of understanding fundamental physics behind their production and acceleration and also their applications in various fields, such as surface properties modification, ion implantation, thin film deposition, semiconductor doping and ion assisted coating. An investigation from a low energy, 1.8 kJ 160 kA, Mather type plasma focus device operating with nitrogen using CR-39 detectors was conducted to study the emission of ions at different angular positions. Tracks on CR-39 detectors at different angular positions reveal the existence of angular ion anisotropy. The results obtained are comparable with the time integrated measurements using FC. Preliminary results of this work are presented.

The hallmarks of premalignant conditions: a molecular basis for cancer prevention

PubMed Central

Ryan, Bríd M.; Faupel-Badger, Jessica M.

2016-01-01

The hallmarks of premalignant lesions were first described in the 1970s, a time when relatively little was known about the molecular underpinnings of cancer. Yet it was clear there must be opportunities to intervene early in carcinogenesis. A vast array of molecular information has since been uncovered, with much of this stemming from studies of existing cancer or cancer models. Here, examples of how an understanding of cancer biology has informed cancer prevention studies are highlighted and emerging areas that may have implications for the field of cancer prevention research are described. A note of caution accompanies these examples, in that while there are similarities, there are also fundamental differences between the biology of premalignant lesions or premalignant conditions and invasive cancer. These differences must be kept in mind, and indeed leveraged, when exploring potential cancer prevention measures. PMID:26970122

Social inequalities in adolescent human papillomavirus (HPV) vaccination: a test of fundamental cause theory.

PubMed

Polonijo, Andrea N; Carpiano, Richard M

2013-04-01

A unique contribution of the fundamental cause theory of health disparities is its ability to account for the persistence of disparities in health and mortality, despite changes in the mechanisms that are relevant at any given time. Few studies, however, have investigated how such mechanisms are created or operate. Examining the introduction of the human papillomavirus (HPV) vaccine for adolescents-a treatment aimed at preventing cervical and other cancers that typically emerge in mid- to late-adulthood-we empirically trace such a disparity-generating mechanism that is in the process of being latently created, testing whether socioeconomic status (SES) and racial/ethnic disparities exist for several facets of vaccination receipt: knowledge about the vaccine, receipt of a health professional recommendation to vaccinate, and initiation and completion of the three-shot vaccination series. Analyses of 2008, 2009, and 2010 United States National Immunization Survey-Teen data (n = 41,358) reveal disparities consistent with fundamental cause theory, particularly for vaccine knowledge and receipt of a health professional recommendation. While parental knowledge is a prerequisite to adolescent vaccine uptake, low SES and racial/ethnic minority parents have significantly lower odds of knowing about the vaccine. Receipt of a health professional's recommendation to vaccinate is strongly associated with vaccine uptake, however the odds of receiving a recommendation are negatively associated with low SES and black racial/ethnic status. Our findings inform fundamental cause theory by illustrating how disparities in distinct stages of the uptake of new treatments may contribute to reproducing existing health disparities-and, in this case of adolescent HPV vaccination, may maintain future disparities in cervical cancer among adult populations. Copyright © 2012 Elsevier Ltd. All rights reserved.

Integrating fundamental movement skills in late childhood.

PubMed

Gimenez, Roberto; Manoel, Edison de J; de Oliveira, Dalton Lustosa; Dantas, Luiz; Marques, Inara

2012-04-01

The study examined how children of different ages integrate fundamental movement skills, such as running and throwing, and whether their developmental status was related to the combination of these skills. Thirty children were divided into three groups (G1 = 6-year-olds, G2 = 9-year-olds, and G3 = 12-year-olds) and filmed performing three tasks: running, overarm throwing, and the combined task. Patterns were identified and described, and the efficiency of integration was calculated (distance differences of the ball thrown in two tasks, overarm throwing and combined task). Differences in integration were related to age: the 6-year-olds were less efficient in combining the two skills than the 9- and 12-year-olds. These differences may be indicative of a phase of integrating fundamental movement skills in the developmental sequence. This developmental status, particularly throwing, seems to be related to the competence to integrate skills, which suggests that fundamental movement skills may be developmental modules.

Functional diversity of potassium channel voltage-sensing domains.

PubMed

Islas, León D

2016-01-01

Voltage-gated potassium channels or Kv's are membrane proteins with fundamental physiological roles. They are composed of 2 main functional protein domains, the pore domain, which regulates ion permeation, and the voltage-sensing domain, which is in charge of sensing voltage and undergoing a conformational change that is later transduced into pore opening. The voltage-sensing domain or VSD is a highly conserved structural motif found in all voltage-gated ion channels and can also exist as an independent feature, giving rise to voltage sensitive enzymes and also sustaining proton fluxes in proton-permeable channels. In spite of the structural conservation of VSDs in potassium channels, there are several differences in the details of VSD function found across variants of Kvs. These differences are mainly reflected in variations in the electrostatic energy needed to open different potassium channels. In turn, the differences in detailed VSD functioning among voltage-gated potassium channels might have physiological consequences that have not been explored and which might reflect evolutionary adaptations to the different roles played by Kv channels in cell physiology.

Functional diversity of potassium channel voltage-sensing domains

PubMed Central

Islas, León D.

2016-01-01

Abstract Voltage-gated potassium channels or Kv's are membrane proteins with fundamental physiological roles. They are composed of 2 main functional protein domains, the pore domain, which regulates ion permeation, and the voltage-sensing domain, which is in charge of sensing voltage and undergoing a conformational change that is later transduced into pore opening. The voltage-sensing domain or VSD is a highly conserved structural motif found in all voltage-gated ion channels and can also exist as an independent feature, giving rise to voltage sensitive enzymes and also sustaining proton fluxes in proton-permeable channels. In spite of the structural conservation of VSDs in potassium channels, there are several differences in the details of VSD function found across variants of Kvs. These differences are mainly reflected in variations in the electrostatic energy needed to open different potassium channels. In turn, the differences in detailed VSD functioning among voltage-gated potassium channels might have physiological consequences that have not been explored and which might reflect evolutionary adaptations to the different roles played by Kv channels in cell physiology. PMID:26794852

The existence of parenting styles in the owner-dog relationship.

PubMed

Herwijnen, Ineke R van; van der Borg, Joanne A M; Naguib, Marc; Beerda, Bonne

2018-01-01

Parents interact with children following specific styles, known to influence child development. These styles represent variations in the dimensions of demandingness and responsiveness, resulting in authoritarian, authoritative, permissive or uninvolved parenting. Given the similarities in the parent to child and owner to dog relationships, we determined the extent to which parenting styles exist in the owner to dog relationship using the existing Parenting Styles and Dimensions Questionnaire for the parent-child relationship and an adapted version for dog owners. Items on the parenting of children/dogs were rated for applicability on a five-point Likert scale by 518 Dutch dog owning parents. Principal Component Analyses grouped parenting propensities into styles, with some marked differences between the findings for children and dogs. Dog-directed items grouped into an authoritarian-correction orientated style, incorporating variation in demandingness and focussing on correcting a dog for behaviour verbally/physically, and in two styles based on authoritative items. An authoritative-intrinsic value orientated style reflected variation in mainly responsiveness and oriented on the assumed needs and emotions of the animal. A second authoritative-item based style, captured variations in demandingness and responsiveness. We labelled this style authoritative-training orientated, as it orientated on manners in teaching a dog how to behave in social situations. Thus, we defined dog-directed parenting styles and constructed a Dog-Directed Parenting Styles and Dimensions Questionnaire along the lines of the existing theoretical framework on parenting styles. We did not find a dog-directed parenting style of being permissive or uninvolved, which we attribute to a study population of devoted dog owners and our findings should be interpreted with this specific study population in mind. We found evidence of dog-directed parenting styles and provide a fundament for determining their possible impact on the different aspects of a dog's life.

Pilot Workload and Speech Analysis: A Preliminary Investigation

NASA Technical Reports Server (NTRS)

Bittner, Rachel M.; Begault, Durand R.; Christopher, Bonny R.

2013-01-01

Prior research has questioned the effectiveness of speech analysis to measure the stress, workload, truthfulness, or emotional state of a talker. The question remains regarding the utility of speech analysis for restricted vocabularies such as those used in aviation communications. A part-task experiment was conducted in which participants performed Air Traffic Control read-backs in different workload environments. Participant's subjective workload and the speech qualities of fundamental frequency (F0) and articulation rate were evaluated. A significant increase in subjective workload rating was found for high workload segments. F0 was found to be significantly higher during high workload while articulation rates were found to be significantly slower. No correlation was found to exist between subjective workload and F0 or articulation rate.

Reward processing in neurodegenerative disease

PubMed Central

Perry, David C.; Kramer, Joel H.

2015-01-01

Representation of reward value involves a distributed network including cortical and subcortical structures. Because neurodegenerative illnesses target specific anatomic networks that partially overlap with the reward circuit they would be predicted to have distinct impairments in reward processing. This review presents the existing evidence of reward processing changes in neurodegenerative diseases including mild cognitive impairment, Alzheimer's disease, frontotemporal dementia, amyotrophic lateral sclerosis, Parkinson's disease, and Huntington's disease, as well as in healthy aging. Carefully distinguishing the different aspects of reward processing (primary rewards, secondary rewards, reward-based learning, and reward-based decision-making) and using tasks that differentiate the stages of processing reward will lead to improved understanding of this fundamental process and clarify a contributing cause of behavioral change in these illnesses. PMID:24417286

In vivo THz sensing of the cornea of the eye

NASA Astrophysics Data System (ADS)

Ozheredov, Ilya; Prokopchuk, Mikhail; Mischenko, Mikhail; Safonova, Tatiana; Solyankin, Petr; Larichev, Andrey; Angeluts, Andrey; Balakin, Alexei; Shkurinov, Alexander

2018-05-01

Measurement of the absolute value of the humidity of the cornea of the human eye and its dynamics is of paramount importance for the preservation of eyesight. In the present paper we have demonstrated that terahertz technologies can be practically applied for quantitative measurement of the physiological dynamics of tear film and sensing of corneal tissue hydration. We suggest uses of the equipment for application in clinics and a method for absolute calibration of the values for measurement. The proposed method is fundamentally different from existing and currently available methods of ophthalmological diagnosis. This suggests that the developed technique may have high diagnostic significance and can be used in the study and treatment of several diseases of the ocular surface.

Multi-segmental movement patterns reflect juggling complexity and skill level.

PubMed

Zago, Matteo; Pacifici, Ilaria; Lovecchio, Nicola; Galli, Manuela; Federolf, Peter Andreas; Sforza, Chiarella

2017-08-01

The juggling action of six experts and six intermediates jugglers was recorded with a motion capture system and decomposed into its fundamental components through Principal Component Analysis. The aim was to quantify trends in movement dimensionality, multi-segmental patterns and rhythmicity as a function of proficiency level and task complexity. Dimensionality was quantified in terms of Residual Variance, while the Relative Amplitude was introduced to account for individual differences in movement components. We observed that: experience-related modifications in multi-segmental actions exist, such as the progressive reduction of error-correction movements, especially in complex task condition. The systematic identification of motor patterns sensitive to the acquisition of specific experience could accelerate the learning process. Copyright © 2017 Elsevier B.V. All rights reserved.

How the Invisible Hand is Supposed to Adjust the Natural Thermostat: A Guide for the Perplexed.

PubMed

Storm, Servaas

2017-10-01

Mainstream climate economics takes global warming seriously, but perplexingly concludes that the optimal economic policy is to almost do nothing about it. This conclusion can be traced to just a few "normative" assumptions, over which there exists fundamental disagreement amongst economists. This paper explores two axes of this disagreement. The first axis ("market vs. regulation") measures faith in the invisible hand to adjust the natural thermostat. The second axis expresses differences in views on the efficiency and equity implications of climate action. The two axes combined lead to a classification of conflicting approaches in climate economics. The variety of approaches does not imply a post-modern "anything goes", as the contradictions between climate and capitalism cannot be wished away.

In-plane stability analysis of non-uniform cross-sectioned curved beams

NASA Astrophysics Data System (ADS)

Öztürk, Hasan; Yeşilyurt, İsa; Sabuncu, Mustafa

2006-09-01

In this study, in-plane stability analysis of non-uniform cross-sectioned thin curved beams under uniformly distributed dynamic loads is investigated by using the Finite Element Method. The first and second unstable regions are examined for dynamic stability. In-plane vibration and in-plane buckling are also studied. Two different finite element models, representing variations of cross-section, are developed by using simple strain functions in the analysis. The results obtained from this study are compared with the results of other investigators in existing literature for the fundamental natural frequency and critical buckling load. The effects of opening angle, variations of cross-section, static and dynamic load parameters on the stability regions are shown in graphics.

Picture Archiving And Communication Systems (PACS): Introductory Systems Analysis Considerations

NASA Astrophysics Data System (ADS)

Hughes, Simon H. C.

1983-05-01

Two fundamental problems face any hospital or radiology department that is thinking about installing a Picture Archiving and Communications System (PACS). First, though the need for PACS already exists, much of the relevant technology is just beginning to be developed. Second, the requirements of each hospital are different, so that any attempts to market a single PACS design for use in large numbers of hospitals are likely to meet with the same problems as were experienced with general-purpose Hospital Information Systems. This paper outlines some of the decision processes involved in arriving at specifications for each module of a PACS and indicates design principles which should be followed in order to meet individual hospital requirements, while avoiding the danger of short-term systems obsolescence.

Transaction-neutral implanted data collection interface as EMR driver: a model for emerging distributed medical technologies.

PubMed

Lorence, Daniel; Sivaramakrishnan, Anusha; Richards, Michael

2010-08-01

Electronic Medical Record (EMR) and Electronic Health Record (EHR) adoption continues to lag across the US. Cost, inconsistent formats, and concerns about control of patient information are among the most common reasons for non-adoption in physician practice settings. The emergence of wearable and implanted mobile technologies, employed in distributed environments, promises a fundamentally different information infrastructure, which could serve to minimize existing adoption resistance. Proposed here is one technology model for overcoming adoption inconsistency and high organization-specific implementation costs, using seamless, patient controlled data collection. While the conceptual applications employed in this technology set are provided by way of illustration, they may also serve as a transformative model for emerging EMR/EHR requirements.

Preliminary study of the effect of the turbulent flow field around complex surfaces on their acoustic characteristics

NASA Technical Reports Server (NTRS)

Olsen, W. A.; Boldman, D.

1978-01-01

Fundamental theories for noise generated by flow over surfaces exist for only a few simple configurations. The role of turbulence in noise generation by complex surfaces should be essentially the same as for simple configurations. Examination of simple-surface theories indicates that the spatial distributions of the mean velocity and turbulence properties are sufficient to define the noise emission. Measurements of these flow properties were made for a number of simple and complex surfaces. The configurations were selected because of their acoustic characteristics are quite different. The spatial distribution of the turbulent flow properties around the complex surfaces and approximate theory are used to locate and describe the noise sources, and to qualitatively explain the varied acoustic characteristics.

Reconstructing the evolution of mind.

PubMed

Povinelli, D J

1993-05-01

Since Darwin, the idea of intellectual continuity has gripped comparative psychology. Psychological evolution has been viewed as the accumulation of gradual changes over time, resulting in an unbroken chain of mental capacities throughout the diversity of life. Some researchers have even maintained that no fundamental psychological differences exist among species. An alternative model argues that a rather profound new psychology related to mental state attribution may have evolved recently in the primate order. The author explores recent experimental research from chimpanzees, rhesus monkeys, and children that is consistent with this second model of psychological evolution. Drawing on the fields of developmental, comparative, and social psychology, as well as evolutionary and developmental biology, the author outlines a research agenda aimed at reconstructing the evolution of metacognition.

Exploiting Helminth-Host Interactomes through Big Data.

PubMed

Sotillo, Javier; Toledo, Rafael; Mulvenna, Jason; Loukas, Alex

2017-11-01

Helminths facilitate their parasitic existence through the production and secretion of different molecules, including proteins. Some helminth proteins can manipulate the host's immune system, a phenomenon that is now being exploited with a view to developing therapeutics for inflammatory diseases. In recent years, hundreds of helminth genomes have been sequenced, but as a community we are still taking baby steps when it comes to identifying proteins that govern host-helminth interactions. The information generated from genomic, immunomic, and proteomic studies, as well as from cutting-edge approaches such as proteogenomics, is leading to a substantial volume of big data that can be utilised to shed light on fundamental biology and provide solutions for the development of bioactive-molecule-based therapeutics. Copyright © 2017 Elsevier Ltd. All rights reserved.

Guidelines for transoesophageal echocardiographic probe cleaning and disinfection from the British Society of Echocardiography.

PubMed

Kanagala, P; Bradley, C; Hoffman, P; Steeds, R P

2011-10-01

The clinical utility of transoesophageal echocardiography (TOE) is well established. Being a semi-invasive procedure, however, the potential for transmission of infection between sequential patients exists. This has implications for the protection of both patients and medical staff. Guidelines for disinfection during gastrointestinal endoscopy (GIE) have been in place for many years.(1,2) Unfortunately, similar guidance is lacking with respect to TOE. Although traversing the same body cavities and sharing many similarities with upper GIE, there are fundamental structural and procedural differences with TOE which merit special consideration in establishing a decontamination protocol. This document provides recommendations for TOE probe decontamination based on the available evidence, expert opinion, and modification of the current British Society of Gastroenterology guidelines.

Stem-cell-derived products: an FDA update.

PubMed

Moos, Malcolm

2008-12-01

The therapeutic potential of products derived from stem cells of various types has prompted increasing research and development and public attention. Initiation of human clinical trials in the not-too-distant future is now a realistic possibility. It is, therefore, important to weigh the potential benefits against known, theoretical and totally unsuspected risks in light of current knowledge to ensure that subjects participating in these trials are afforded the most reasonable balance possible between potential risks and potential benefits. There are no apparent differences in fundamental, qualitative biological characteristics between stem-cell-derived products and other cellular therapies regulated by the United States Food and Drug Administration (FDA). Existing authorities can, therefore, be applied. Nevertheless, these products do have properties that require careful evaluation.

[The banishment of the marvellous. Hermaphrodites and sexual mutants in Enlightenment Spain].

PubMed

Vásquez, Francisco; Cleminson, Richard

2011-01-01

This article presents a historical synthesis in order to trace how the collective belief in the existence of hermaphrodites and sex-changes was slowly eroded in the changing medical and cultural context of Enlightenment Spain. In order to explain this change, three interlinked processes are outlined. First, the naturalization of the monster and the disappearance of the "marvellous" in Enlightenment science. Second, the consolidation of modern legal or forensic science and the rise of the medical specialist as the relevant authority in the determination of sexual identity. Third, the emergence of the notion of fundamental biological differences between the sexes. The article concludes by discussing the consequences of these shifts for early nineteenth-century Spanish medicine.

Central Tendency and Dispersion Measures of the Fundamental Frequencies of Four Vowels as Produced by Two Year-Old and Four-Year Children.

NASA Astrophysics Data System (ADS)

Monroe, Roberta Lynn

The intrinsic fundamental frequency effect among vowels is a vocalic phenomenon of adult speech in which high vowels have higher fundamental frequencies in relation to low vowels. Acoustic investigations of children's speech have shown that variability of the speech signal decreases as children's ages increase. Fundamental frequency measures have been suggested as an indirect metric for the development of laryngeal stability and coordination. Studies of the intrinsic fundamental frequency effect have been conducted among 8- and 9-year old children and in infants. The present study investigated this effect among 2- and 4-year old children. Eight 2-year old and eight 4-year old children produced four vowels, /ae/, /i/, /u/, and /a/, in CVC syllables. Three measures of fundamental frequency were taken. These were mean fundamental frequency, the intra-utterance standard deviation of the fundamental frequency, and the extent to which the cycle-to-cycle pattern of the fundamental frequency was predicted by a linear trend. An analysis of variance was performed to compare the two age groups, the four vowels, and the earlier and later repetitions of the CVC syllables. A significant difference between the two age groups was detected using the intra-utterance standard deviation of the fundamental frequency. Mean fundamental frequencies and linear trend analysis showed that voicing of the preceding consonant determined the statistical significance of the age-group comparisons. Statistically significant differences among the fundamental frequencies of the four vowels were not detected for either age group.

Unraveling hidden order in the dynamics of developed and emerging markets.

PubMed

Berman, Yonatan; Shapira, Yoash; Ben-Jacob, Eshel

2014-01-01

The characterization of asset price returns is an important subject in modern finance. Traditionally, the dynamics of stock returns are assumed to lack any temporal order. Here we present an analysis of the autocovariance of stock market indices and unravel temporal order in several major stock markets. We also demonstrate a fundamental difference between developed and emerging markets in the past decade - emerging markets are marked by positive order in contrast to developed markets whose dynamics are marked by weakly negative order. In addition, the reaction to financial crises was found to be reversed among developed and emerging markets, presenting large positive/negative autocovariance spikes following the onset of these crises. Notably, the Chinese market shows neutral or no order while being regarded as an emerging market. These findings show that despite the coupling between international markets and global trading, major differences exist between different markets, and demonstrate that the autocovariance of markets is correlated with their stability, as well as with their state of development.

Unraveling Hidden Order in the Dynamics of Developed and Emerging Markets

PubMed Central

Berman, Yonatan; Shapira, Yoash; Ben-Jacob, Eshel

2014-01-01

The characterization of asset price returns is an important subject in modern finance. Traditionally, the dynamics of stock returns are assumed to lack any temporal order. Here we present an analysis of the autocovariance of stock market indices and unravel temporal order in several major stock markets. We also demonstrate a fundamental difference between developed and emerging markets in the past decade - emerging markets are marked by positive order in contrast to developed markets whose dynamics are marked by weakly negative order. In addition, the reaction to financial crises was found to be reversed among developed and emerging markets, presenting large positive/negative autocovariance spikes following the onset of these crises. Notably, the Chinese market shows neutral or no order while being regarded as an emerging market. These findings show that despite the coupling between international markets and global trading, major differences exist between different markets, and demonstrate that the autocovariance of markets is correlated with their stability, as well as with their state of development. PMID:25383630

Distrust As a Disease Avoidance Strategy: Individual Differences in Disgust Sensitivity Regulate Generalized Social Trust.

PubMed

Aarøe, Lene; Osmundsen, Mathias; Petersen, Michael Bang

2016-01-01

Throughout human evolutionary history, cooperative contact with others has been fundamental for human survival. At the same time, social contact has been a source of threats. In this article, we focus on one particular viable threat, communicable disease, and investigate how motivations to avoid pathogens influence people's propensity to interact and cooperate with others, as measured by individual differences in generalized social trust. While extant studies on pathogen avoidance have argued that such motivations should prompt people to avoid interactions with outgroups specifically, we argue that these motivations should prompt people to avoid others more broadly. Empirically, we utilize two convenience samples and a large nationally representative sample of US citizens to demonstrate the existence of a robust and replicable effect of individual differences in pathogen disgust sensitivity on generalized social trust. We furthermore compare the effects of pathogen disgust sensitivity on generalized social trust and outgroup prejudice and explore whether generalized social trust to some extent constitutes a pathway between pathogen avoidance motivations and prejudice.

Theoretical studies of superconductivity in doped BaCoSO

NASA Astrophysics Data System (ADS)

Qin, Shengshan; Li, Yinxiang; Zhang, Qiang; Le, Congcong; Hu, Jiangping

2018-06-01

We investigate superconductivity that may exist in the doped BaCoSO, a multi-orbital Mott insulator with a strong antiferromagnetic ground state. The superconductivity is studied in both t-J type and Hubbard type multi-orbital models by mean field approach and random phase approximation (RPA) analysis. Even if there is no C 4 rotational symmetry, it is found that the system still carries a d-wave like pairing symmetry state with gapless nodes and sign changed superconducting order parameters on Fermi surfaces. The results are largely doping insensitive. In this superconducting state, the three {t_{{2_g}}} orbitals have very different superconducting form factors in momentum space. In particular, the intra-orbital pairing of the {d_{{x^2} - {y^2}}} orbital has an s-wave like pairing form factor. The two methods also predict very different pairing strength on different parts of Fermi surfaces. These results suggest that BaCoSO and related materials can be a new ground to test and establish fundamental principles for unconventional high temperature superconductivity.

Distrust As a Disease Avoidance Strategy: Individual Differences in Disgust Sensitivity Regulate Generalized Social Trust

PubMed Central

Aarøe, Lene; Osmundsen, Mathias; Petersen, Michael Bang

2016-01-01

Throughout human evolutionary history, cooperative contact with others has been fundamental for human survival. At the same time, social contact has been a source of threats. In this article, we focus on one particular viable threat, communicable disease, and investigate how motivations to avoid pathogens influence people's propensity to interact and cooperate with others, as measured by individual differences in generalized social trust. While extant studies on pathogen avoidance have argued that such motivations should prompt people to avoid interactions with outgroups specifically, we argue that these motivations should prompt people to avoid others more broadly. Empirically, we utilize two convenience samples and a large nationally representative sample of US citizens to demonstrate the existence of a robust and replicable effect of individual differences in pathogen disgust sensitivity on generalized social trust. We furthermore compare the effects of pathogen disgust sensitivity on generalized social trust and outgroup prejudice and explore whether generalized social trust to some extent constitutes a pathway between pathogen avoidance motivations and prejudice. PMID:27516744

Learning Potential and Cognitive Modifiability

ERIC Educational Resources Information Center

Kozulin, Alex

2011-01-01

The relationship between thinking and learning constitutes one of the fundamental problems of cognitive psychology. Though there is an obvious overlap between the domains of thinking and learning, it seems more productive to consider learning as being predominantly acquisition while considering thinking as the application of the existent concepts…

Knowledge Management Systems: Linking Contribution, Refinement and Use

ERIC Educational Resources Information Center

Chung, Ting-ting

2009-01-01

Electronic knowledge repositories represent one of the fundamental tools for knowledge management (KM) initiatives. Existing research, however, has largely focused on supply-side driven research questions, such as employee motivation to contribute knowledge to a repository. This research turns attention to the dynamic relationship between the…

A SCIENTIFIC AND TECHNOLOGICAL FRAMEWORK FOR EVALUATING COMPARATIVE RISK IN ECOLOGICAL RISK ASSESSMENTS

EPA Science Inventory

There are significant scientific and technological challenges to managing natural resources. Data needs are cited as an obvious limitation, but there exist more fundamental scientific issues. What is still needed is a method of comparing management strategies based on projected i...

An Environmental Education Program (K-12), Based on Environmental Encounters

ERIC Educational Resources Information Center

Stapp, William B.

1971-01-01

Describes a strategy for development and implementation of a comprehensive environmental education program (K-12) which can be integrated into existing curriculum of a school. Environmental encounters" stressed as meaningful approaches to goal achievement. Philosophy of spaceship earth" is fundamental to the program. (LK)

Mechanisms for Robust Cognition

ERIC Educational Resources Information Center

Walsh, Matthew M.; Gluck, Kevin A.

2015-01-01

To function well in an unpredictable environment using unreliable components, a system must have a high degree of robustness. Robustness is fundamental to biological systems and is an objective in the design of engineered systems such as airplane engines and buildings. Cognitive systems, like biological and engineered systems, exist within…

Management and analysis of Michigan intelligent transportation systems center data with application to the Detroit area I-75 corridor.

DOT National Transportation Integrated Search

2011-02-01

An understanding of traffic flow in time and space is fundamental to the development of : strategies for the efficient use of the existing transportation infrastructure in large : metropolitan areas. Thus, this project involved developing the methods...

How To Make Innovations Practical

ERIC Educational Resources Information Center

Janssen, Fred; Westbroek, Hanna; Doyle, Walter; van Driel, Jan

2013-01-01

Background/Context: A fundamental tension has long existed between school reform proposals and actual teaching practice. Despite a large literature on teacher change, the discontinuity between innovation and practice continues and many attempts to reform teaching fail to be enacted in most classrooms. Purpose/Objective/Research Question/Focus of…

Salience of Primary and Secondary Colours in Infancy

ERIC Educational Resources Information Center

Franklin, Anna; Pitchford, Nicola; Hart, Lynsey; Davies, Ian R. L.; Clausse, Samantha; Jennings, Siobhan

2008-01-01

Primary colour terms ("black", "white", "red", "green", "yellow", and "blue") are more fundamental in colour language than secondary colour terms ("pink", "purple", "orange", "brown", and "grey"). Here, we assess whether this distinction exists in the absence of language, by investigating whether primary colours attract and sustain preverbal…

A Smorgasbord of Assessment Options

ERIC Educational Resources Information Center

Bacon, Kathy A.

2010-01-01

The wealth of assessment options that exists offers teachers and students a "menu" of selections. Just as matching appetite needs with appropriate food selection is fundamental to a successful dining experience, matching assessment options to targeted achievement needs is crucial to an effective assessment experience. The author uses a…

Searching for Ideal Contraceptives.

ERIC Educational Resources Information Center

Djerassi, Carl

1985-01-01

Discusses the problem of adolescent pregnancy and focuses on improving contraception as a practical solution. Describes the advantages and disadvantages of existing methods (the condom, the pill, and the contraceptive sponge). Predicts that the development of a fundamentally new contraceptive, such as a monthly menses-inducer pill, will not occur…

The Ideological Foundations of Midwest Rural Education.

ERIC Educational Resources Information Center

Theobald, Paul

A relationship exists between agrarian thought and the practice of formal schooling in the rural Midwest. Three traditions have shaped agrarian thinking about democracy and its application to social institutions, especially education. Fundamentalism, localism, and pastoralism have combined to form the ideological base for rural resistance to…

How Are Transpersonal Experience and Personal Maturity Related?

ERIC Educational Resources Information Center

Koltko, Mark Edward

This study examined one of the fundamental questions in humanistic and transpersonal psychology: what kind of relationship exists between transcendent experience and personal psychological well-being? College undergraduates (N=92) at three colleges were asked to recall their "most wonderful" experience, and then to complete an adaptation…

Slash application reduces soil erosion in steep-sloped piñon-juniper woodlands

USDA-ARS?s Scientific Manuscript database

Mitigating runoff and associated erosion is a fundamental challenge for sustainable management of rangelands. Hillslope runoff and erosion are strongly influenced by ground cover, thus, a strategic management option exists to increase cover with slash from woody plant removal activities particularl...

Theoretical and experimental investigation of supersonic aerodynamic characteristics of a twin-fuselage concept

NASA Technical Reports Server (NTRS)

Wood, R. M.; Miller, D. S.; Brentner, K. S.

1983-01-01

A theoretical and experimental investigation has been conducted to evaluate the fundamental supersonic aerodynamic characteristics of a generic twin-body model at a Mach number of 2.70. Results show that existing aerodynamic prediction methods are adequate for making preliminary aerodynamic estimates.

Critical success factors for competitiveness of construction companies: A critical review

NASA Astrophysics Data System (ADS)

Hanafi, Abdul Ghafur; Nawi, Mohd Nasrun Mohd

2016-08-01

Making progress basically, a fundamental issue for the construction companies to get by in a highly competitive industry. From time to time, industry players are facing stiff and tough competition due to large number of players, whether existing or new players involved from various background and track record. Furthermore, the large numbers of component deciding the competitiveness of contractors, whose organization structures and governance have turned out to be more muddled. Different construction companies have their own unique criteria which may differ from one to another. The enormous amount of issues needs to bring down to manageable numbers so that measures can be identified and scrutinized to enhance competitiveness. This paper discusses the result from the critical investigation from past studies in the Asian countries, namely China, India, Thailand, Singapore and Malaysia. Several fundamental factors have been identified as CSFs in construction companies in respective country. Also highlighted a critical survey based upon various literatures written on this subject where critical success factors (CSFs) as a yardstick to gauge the relationship among CSFs in various construction companies in the Asian region. Far reaching estimation of an organization's performance and resulting input to its supervision is crucial for business change. Estimation additionally empowers organizations to be contrasted from one another on the premise of institutionalized data, permitting best practices to be distinguished and connected more widely. Different countries have their own set of critical success factors (CSFs) which may differ in term of priority and at the same time share common elements of success factor in accomplishment as a construction companies. The study, which is exploratory in nature, embraced the content investigation and inductive technique to accomplish its objectives.

Selective laser spectroscopy of molecules and ions in solids: a history, fundamentals and applications

NASA Astrophysics Data System (ADS)

Sapozhnikov, Michael

2018-03-01

A history of the development of selective laser spectroscopy is presented, beginning with a pioneering work by Yu. V. Denisov and V. A. Kizel in 1967, who were the first to demonstrate the possibility of removing the inhomogeneous broadening of luminescence spectra of impurity ions in glasses upon monochromatic resonance excitation. Selective excitation of optical centers can be achieved due to existence of zero-phonon transitions corresponding to narrow homogeneous zero-phonon lines in the spectra of impurity centers in solids, which are hidden in broad inhomogeneous optical bands upon usual nonselective excitation. The fundamentals of zero-phonon transition spectroscopy are considered and the mechanism of removing the inhomogeneous broadening of optical spectra of ions and molecules in crystals and amorphous solids under selective laser excitation of luminescence and persistent hole burning in absorption spectra is presented in detail. Various applications of selective laser spectroscopy for fundamental and applied studies are discussed.

Why firewalls need not exist

DOE PAGES

Nomura, Yasunori; Salzetta, Nico

2016-08-04

The firewall paradox for black holes is often viewed as indicating a conflict between unitarity and the equivalence principle. We elucidate how the paradox manifests as a limitation of semiclassical theory, rather than presents a conflict between fundamental principles. Two principal features of the fundamental and semiclassical theories address two versions of the paradox: the entanglement and typicality arguments. First, the physical Hilbert space describing excitations on a fixed black hole background in the semiclassical theory is exponentially smaller than the number of physical states in the fundamental theory of quantum gravity. Second, in addition to the Hilbert space formore » physical excitations, the semiclassical theory possesses an unphysically large Fock space built by creation and annihilation operators on the fixed black hole background. Understanding these features not only eliminates the necessity of firewalls but also leads to a new picture of Hawking emission contrasting pair creation at the horizon.« less

A defense of fundamental principles and human rights: a reply to Robert Baker.

PubMed

Macklin, Ruth

1998-12-01

This article seeks to rebut Robert Baker's contention that attempts to ground international bioethics in fundamental principles cannot withstand the challenges posed by multiculturalism and postmodernism. First, several corrections are provided of Baker's account of the conclusions reached by the Advisory Committee on Human Radiation Experiments. Second, a rebuttal is offered to Baker's claim that an unbridgeable moral gap exists between Western individualism and non-Western communalism. In conclusion, this article argues that Baker's "nonnegotiable primary goods" cannot do the work of "classical human rights" and that the latter framework is preferable from both a practical and a theoretical standpoint.

Fundamental kinetics and mechanistic pathways for oxidation reactions in supercritical water

NASA Technical Reports Server (NTRS)

Webley, Paul A.; Tester, Jefferson W.

1988-01-01

Oxidation of the products of human metabolism in supercritical water has been shown to be an efficient way to accomplish the on-board water/waste recycling in future long-term space flights. Studies of the oxidation kinetics of methane to carbon dioxide in supercritical water are presented in this paper in order to enhance the fundamental understanding of the oxidation of human waste compounds in supercritical water. It is concluded that, although the elementary reaction models remain the best hope for simulating oxidation in supercritical water, several modifications to existing mechanisms need to be made to account for the role of water in the reaction mechanism.

Reduction of vibration by using mechatronical subsystem

NASA Astrophysics Data System (ADS)

Białas, K.; Buchacz, A.

2015-11-01

The primary aim introduced in this paper is synthesis of mechatronical system understand as planning of this type of systems. Mechatronical system is consisted of fundamental mechanical system and subsystem reducing vibration including electric elements. Fundamental system is received applying reverse task of dynamic (synthesis) and it's including inertial and elastic elements. The subsystem includes electric elements by means moving-coil transducer. The synthesis can also be used to change the already existing systems. Due to the method, introduced in this work, may be performed as early as whilst the designing of future functions. Using this way of designing is support for designers of mechanical systems with active reducing of vibrations.

Liquid Organic Hydrogen Carriers (LOHCs): Toward a Hydrogen-free Hydrogen Economy.

PubMed

Preuster, Patrick; Papp, Christian; Wasserscheid, Peter

2017-01-17

The need to drastically reduce CO 2 emissions will lead to the transformation of our current, carbon-based energy system to a more sustainable, renewable-based one. In this process, hydrogen will gain increasing importance as secondary energy vector. Energy storage requirements on the TWh scale (to bridge extended times of low wind and sun harvest) and global logistics of renewable energy equivalents will create additional driving forces toward a future hydrogen economy. However, the nature of hydrogen requires dedicated infrastructures, and this has prevented so far the introduction of elemental hydrogen into the energy sector to a large extent. Recent scientific and technological progress in handling hydrogen in chemically bound form as liquid organic hydrogen carrier (LOHC) supports the technological vision that a future hydrogen economy may work without handling large amounts of elemental hydrogen. LOHC systems are composed of pairs of hydrogen-lean and hydrogen-rich organic compounds that store hydrogen by repeated catalytic hydrogenation and dehydrogenation cycles. While hydrogen handling in the form of LOHCs allows for using the existing infrastructure for fuels, it also builds on the existing public confidence in dealing with liquid energy carriers. In contrast to hydrogen storage by hydrogenation of gases, such as CO 2 or N 2 , hydrogen release from LOHC systems produces pure hydrogen after condensation of the high-boiling carrier compounds. This Account highlights the current state-of-the-art in hydrogen storage using LOHC systems. It first introduces fundamental aspects of a future hydrogen economy and derives therefrom requirements for suitable LOHC compounds. Molecular structures that have been successfully applied in the literature are presented, and their property profiles are discussed. Fundamental and applied aspects of the involved hydrogenation and dehydrogenation catalysis are discussed, characteristic differences for the catalytic conversion of pure hydrocarbon and nitrogen-containing LOHC compounds are derived from the literature, and attractive future research directions are highlighted. Finally, applications of the LOHC technology are presented. This part covers stationary energy storage (on-grid and off-grid), hydrogen logistics, and on-board hydrogen production for mobile applications. Technology readiness of these fields is very different. For stationary energy storage systems, the feasibility of the LOHC technology has been recently proven in commercial demonstrators, and cost aspects will decide on their further commercial success. For other highly attractive options, such as, hydrogen delivery to hydrogen filling stations or direct-LOHC-fuel cell applications, significant efforts in fundamental and applied research are still needed and, hopefully, encouraged by this Account.

Simplified Summative Temporal Bone Dissection Scale Demonstrates Equivalence to Existing Measures.

PubMed

Pisa, Justyn; Gousseau, Michael; Mowat, Stephanie; Westerberg, Brian; Unger, Bert; Hochman, Jordan B

2018-01-01

Emphasis on patient safety has created the need for quality assessment of fundamental surgical skills. Existing temporal bone rating scales are laborious, subject to evaluator fatigue, and contain inconsistencies when conferring points. To address these deficiencies, a novel binary assessment tool was designed and validated against a well-established rating scale. Residents completed a mastoidectomy with posterior tympanotomy on identical 3D-printed temporal bone models. Four neurotologists evaluated each specimen using a validated scale (Welling) and a newly developed "CanadaWest" scale, with scoring repeated after a 4-week interval. Nineteen participants were clustered into junior, intermediate, and senior cohorts. An ANOVA found significant differences between performance of the junior-intermediate and junior-senior cohorts for both Welling and CanadaWest scales ( P < .05). Neither scale found a significant difference between intermediate-senior resident performance ( P > .05). Cohen's kappa found strong intrarater reliability (0.711) with a high degree of interrater reliability of (0.858) for the CanadaWest scale, similar to scores on the Welling scale of (0.713) and (0.917), respectively. The CanadaWest scale was facile and delineated performance by experience level with strong intrarater reliability. Comparable to the validated Welling Scale, it distinguished junior from senior trainees but was challenged in differentiating intermediate and senior trainee performance.

An approach to multiscale modelling with graph grammars.

PubMed

Ong, Yongzhi; Streit, Katarína; Henke, Michael; Kurth, Winfried

2014-09-01

Functional-structural plant models (FSPMs) simulate biological processes at different spatial scales. Methods exist for multiscale data representation and modification, but the advantages of using multiple scales in the dynamic aspects of FSPMs remain unclear. Results from multiscale models in various other areas of science that share fundamental modelling issues with FSPMs suggest that potential advantages do exist, and this study therefore aims to introduce an approach to multiscale modelling in FSPMs. A three-part graph data structure and grammar is revisited, and presented with a conceptual framework for multiscale modelling. The framework is used for identifying roles, categorizing and describing scale-to-scale interactions, thus allowing alternative approaches to model development as opposed to correlation-based modelling at a single scale. Reverse information flow (from macro- to micro-scale) is catered for in the framework. The methods are implemented within the programming language XL. Three example models are implemented using the proposed multiscale graph model and framework. The first illustrates the fundamental usage of the graph data structure and grammar, the second uses probabilistic modelling for organs at the fine scale in order to derive crown growth, and the third combines multiscale plant topology with ozone trends and metabolic network simulations in order to model juvenile beech stands under exposure to a toxic trace gas. The graph data structure supports data representation and grammar operations at multiple scales. The results demonstrate that multiscale modelling is a viable method in FSPM and an alternative to correlation-based modelling. Advantages and disadvantages of multiscale modelling are illustrated by comparisons with single-scale implementations, leading to motivations for further research in sensitivity analysis and run-time efficiency for these models.

An approach to multiscale modelling with graph grammars

PubMed Central

Ong, Yongzhi; Streit, Katarína; Henke, Michael; Kurth, Winfried

2014-01-01

Background and Aims Functional–structural plant models (FSPMs) simulate biological processes at different spatial scales. Methods exist for multiscale data representation and modification, but the advantages of using multiple scales in the dynamic aspects of FSPMs remain unclear. Results from multiscale models in various other areas of science that share fundamental modelling issues with FSPMs suggest that potential advantages do exist, and this study therefore aims to introduce an approach to multiscale modelling in FSPMs. Methods A three-part graph data structure and grammar is revisited, and presented with a conceptual framework for multiscale modelling. The framework is used for identifying roles, categorizing and describing scale-to-scale interactions, thus allowing alternative approaches to model development as opposed to correlation-based modelling at a single scale. Reverse information flow (from macro- to micro-scale) is catered for in the framework. The methods are implemented within the programming language XL. Key Results Three example models are implemented using the proposed multiscale graph model and framework. The first illustrates the fundamental usage of the graph data structure and grammar, the second uses probabilistic modelling for organs at the fine scale in order to derive crown growth, and the third combines multiscale plant topology with ozone trends and metabolic network simulations in order to model juvenile beech stands under exposure to a toxic trace gas. Conclusions The graph data structure supports data representation and grammar operations at multiple scales. The results demonstrate that multiscale modelling is a viable method in FSPM and an alternative to correlation-based modelling. Advantages and disadvantages of multiscale modelling are illustrated by comparisons with single-scale implementations, leading to motivations for further research in sensitivity analysis and run-time efficiency for these models. PMID:25134929

Do Students Need to Be Taught How to Reason?

ERIC Educational Resources Information Center

Kuhn, Deanna

2009-01-01

In this theoretical essay, the author addresses the existence of divergent evidence, portraying both competence and lack of competence in a fundamental realm of higher order thinking--causal and scientific reasoning--and explores the educational implications. Evidence indicates that these higher order reasoning skills are not ones that can be…

Reviewing the Connection between Paradigms and Theories to Understand Adolescent Drug Use

ERIC Educational Resources Information Center

Clark, Trenette T.

2010-01-01

Approaches to studying social phenomenon are fundamentally based upon personal beliefs about the nature of knowledge, reality, and order. Scholars, researchers, and practitioners can benefit from utilizing a coherent method that organizes the wide array of perspectives that exist and the theories, practice, prevention interventions, and policies…

Measurement of the helicity of W bosons in top quark decays

DOE Office of Scientific and Technical Information (OSTI.GOV)

Winn, David Jerome

2000-01-01

This thesis describes a measurement o f the decay properties of the top quark. The six quarks are fundamental building blocks matter in the universe. The most common quarks, named up and down, combine to form the protons and neutrons which exist at the nucleus of all atoms.

Multiple Intelligences, Judgment, and Realization of Value

ERIC Educational Resources Information Center

Blomberg, Doug

2009-01-01

In the theory of multiple intelligences, Howard Gardner proposes a scientific justification for a more pluralistic pedagogy, while denying that science can determine educational goals. Wearing an educator's hat, however, he favors a pathway in which students come "to understand the most fundamental questions of existence ... familiarly, the true,…

Under the Shadow of New Technology.

ERIC Educational Resources Information Center

Hsia, H. J.

Because of the drastic reduction in prices and the availability of versatile, inexpensive software, the home computer today is enjoying an exponential growth and may be effecting a fundamental change in mass communication and processes. Existing media suffer from many inherent limitations and offer unspecified audiences very low or no referability…

Teaching with Social Media: Disrupting Present Day Public Education

ERIC Educational Resources Information Center

Meabon Bartow, Susan

2014-01-01

Because social technologies present illuminating educational, ethical, economic, and structural challenges to existing constructions of public education, they catalyze a fundamental examination of what public education should look like and be like in a democracy. Given their performances in other arenas, mobile and electronic technologies have the…

6 CFR 15.50 - Program accessibility; existing facilities.

Code of Federal Regulations, 2010 CFR

2010-01-01

... ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF DISABILITY IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE... Department shall operate each program or activity so that the program or activity, when viewed in its... result in a fundamental alteration in the nature of a program or activity or in undue financial and...

38 CFR 15.150 - Program accessibility: Existing facilities.

Code of Federal Regulations, 2010 CFR

2010-07-01

... AFFAIRS ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY.... The agency shall operate each program or activity so that the program or activity, when viewed in its... fundamental alteration in the nature of a program or activity or in undue financial and administrative burdens...

22 CFR 219.150 - Program accessibility: Existing facilities.

Code of Federal Regulations, 2010 CFR

2010-04-01

... NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY INTERNATIONAL DEVELOPMENT.... (a) General. The agency shall operate each program or activity so that the program or activity, when... result in a fundamental alteration in the nature of a program or activity or in undue financial and...

16 CFR 6.150 - Program accessibility: Existing facilities.

Code of Federal Regulations, 2010 CFR

2010-01-01

... OF PRACTICE ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES.... The Commission shall operate each program or activity so that the program or activity, when viewed in... demonstrate would result in a fundamental alteration in the nature of a program or activity or in undue...

49 CFR 28.150 - Program accessibility: Existing facilities.

Code of Federal Regulations, 2010 CFR

2010-10-01

... ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE DEPARTMENT OF TRANSPORTATION § 28... or activity so that the program or activity, when viewed in its entirety, is readily accessible to... fundamental alteration in the nature of a program or activity or in undue financial and administrative burdens...

36 CFR 812.150 - Program accessibility: Existing facilities.

Code of Federal Regulations, 2010 CFR

2010-07-01

... HISTORIC PRESERVATION ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES... facilities. (a) General. The agency shall operate each program or activity so that the program or activity... fundamental alteration in the nature of a program or activity or in undue financial and administrative burdens...

29 CFR 2205.150 - Program accessibility: Existing facilities.

Code of Federal Regulations, 2010 CFR

2010-07-01

... COMMISSION ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY... facilities. (a) General. The agency shall operate each program or activity so that the program or activity... fundamental alteration in the nature of a program or activity or in undue financial and administrative burdens...

45 CFR 606.51 - Program accessibility: Existing facilities.

Code of Federal Regulations, 2010 CFR

2010-10-01

... FOUNDATION ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY... Foundation shall operate each program or activity so that the program or activity, when viewed in its... result in a fundamental alteration in the nature of a program or activity or in undue financial and...

29 CFR 2706.150 - Program accessibility: Existing facilities.

Code of Federal Regulations, 2010 CFR

2010-07-01

... COMMISSION ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY... facilities. (a) General. The agency shall operate each program or activity so that the program or activity... fundamental alteration in the nature of a program or activity or in undue financial and administrative burdens...

36 CFR 909.150 - Program accessibility: Existing facilities.

Code of Federal Regulations, 2010 CFR

2010-07-01

... DEVELOPMENT CORPORATION ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES... facilities. (a) General. The agency shall operate each program or activity so that the program or activity... fundamental alteration in the nature of a program or activity or in undue financial and administrative burdens...

5 CFR 2416.150 - Program accessibility: Existing facilities.

Code of Federal Regulations, 2010 CFR

2010-01-01

... ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE FEDERAL... shall operate each program or activity so that the program or activity, when viewed in its entirety, is... fundamental alteration in the nature of a program or activity or in undue financial and administrative burdens...

Teaching IP Networking Fundamentals in Resource Constrained Educational Environments

ERIC Educational Resources Information Center

Armitage, Grenville; Harrop, Warren

2005-01-01

Many educational institutions suffer from a lack of funding to keep telecommunications laboratory classes up to date and flexible. This paper describes our Remote Unix Lab Environment (RULE), a solution for exposing students to the latest Internet based telecommunications software tools in a Unix like environment. RULE leverages existing PC…

On the Sustainability and Management of a Model System with Ecological, Macroeconomic, and Legal Components

EPA Science Inventory

Sustainability is essentially about insuring that human existence can be indefinitely supported by the biological system of the Earth at an appropriate level of civilization. Hence, one of the most fundamental questions in sustainability is the extent to which human activities a...

Linguistic Problems in the Work of the Translator.

ERIC Educational Resources Information Center

Szymczak, M.

Noting that no clear and adequate basis for a theory of translation exists at this time, this article examines problems common to three fundamental elements of translation. Illustrative examples, taken from Slavic languages, relate to discussion of grammatical, semantic-lexical, and stylistic aspects of translation. Various contributions of…

Relating nanoindentation to macroindentation of wood

Treesearch

Robert J. Moon; Joseph E. Jakes; Jim F. Beecher; Charles R. Frihart; Donald S. Stone

2009-01-01

Wood has several levels of hierarchical structure, spanning from the configuration of growth-rings down to the configuration of the base polymers (cellulose, hemicellulose, and lignin). The bulk properties of wood result from the culmination of interactions over all length scales. Gaps presently exist in the fundamental knowledge relating the contribution of wood...

Validity Evidence for a Learning Progression of Scientific Explanation

ERIC Educational Resources Information Center

Yao, Jian-Xin; Guo, Yu-Ying

2018-01-01

Providing scientific explanations for natural phenomena is a fundamental aim of science; therefore, scientific explanation has been selected as one of the key practices in science education policy documents around the world. To further elaborate on existing educational frameworks of scientific explanation in K-12, we propose a learning progression…

A COMPREHENSIVE APPROACH TO IDENTIFY AND QUANTIFY FUNDAMENTAL PARAMETERS THAT INFLUENCE METAL LEACHING CHEMISTRY IN LANDFILLS SYSTEMS (PRESENTATION)

EPA Science Inventory

Various anthropogenic activities generate hazardous solid wastes that are affluent in heavy metals, which can cause significant damage to the environment and human health. Heavy metals/metalloids can exist in multiple oxidation states, and can undergo oxidation or reduction when ...

A COMPREHENSIVE APPROACH TO IDENTIFY AND QUANTIFY FUNDAMENTAL PARAMETERS THAT INFLUENCE METAL LEACHING CHEMISTRY IN LANDFILLS SYSTEMS (ABSTRACT)

EPA Science Inventory

Various anthropogenic activities generate hazardous solid wastes that are affluent in heavy metals, which can cause significant damage to the environment and human health. Heavy metals/metalloids can exist in multiple oxidation states, and can undergo oxidation or reduction when ...

Speech Motor Development: Integrating Muscles, Movements, and Linguistic Units

ERIC Educational Resources Information Center

Smith, Anne

2006-01-01

A fundamental problem for those interested in human communication is to determine how ideas and the various units of language structure are communicated through speaking. The physiological concepts involved in the control of muscle contraction and movement are theoretically distant from the processing levels and units postulated to exist in…

Basins of distinct asymptotic states in the cyclically competing mobile five species game

NASA Astrophysics Data System (ADS)

Kim, Beomseok; Park, Junpyo

2017-10-01

We study the dynamics of cyclic competing mobile five species on spatially extended systems originated from asymmetric initial populations and investigate the basins for the three possible asymptotic states, coexistence of all species, existences of only two independent species, and the extinction. Through extensive numerical simulations, we find a prosperous dependence on initial conditions for species biodiversity. In particular, for fixed given equal densities of two relevant species, we find that only five basins for the existence of two independent species exist and they are spirally entangled for high mobility. A basin of coexistence is outbreaking when the mobility parameter is decreased through a critical value and surrounded by the other five basins. For fixed given equal densities of two independent species, however, we find that basin structures are not spirally entangled. Further, final states of two independent species are totally different. For all possible considerations, the extinction state is not witnessed which is verified by the survival probability. To provide the validity of basin structures from lattice simulations, we analyze the system in mean-field manners. Consequently, results on macroscopic levels are matched to direct lattice simulations for high mobility regimes. These findings provide a good insight into the fundamental issue of the biodiversity among many species than previous cases.

If technological intelligent extraterrestrials exist, what biological traits are de rigueur

NASA Astrophysics Data System (ADS)

Taylor, E. R.

2018-05-01

If extraterrestrials exist in the depths of cosmic space, and are capable of interstellar communications, even space flight, there is no requirement that they be humanoid in form. However, certain humanoid capabilities would be advantageous for tool fashioning and critical to operating space craft as well as functioning under the disparate extreme conditions under which they may be forced to operate. They would have to be "gas breathing". The reasonable assumption that life based upon the same elements as Earth life requiring water stems from the unique properties of water that no other similar low molecular weight nonmetal hydride offers. Only water offers the diversity of chemical properties and reactivity, including the existence of the three common physical states within a limited temperature range of service to life, avoiding the issues presented by any alternatives. They must, like us, possess a large, abstract-thinking brain, and probably possess at least all the fundamental senses that humankind possess. They would also be carbon-based life, using oxygen as the electron sink of their biochemistry for the reasons considered. They most likely are homeothermic as us, though they may not necessarily be mammalian as we are. Their biochemistry could differ some from ours, perhaps presenting contact hazards for both species as discussed.

Fluvial geomorphology on Earth-like planetary surfaces: A review

PubMed Central

Baker, Victor R.; Hamilton, Christopher W.; Burr, Devon M.; Gulick, Virginia C.; Komatsu, Goro; Luo, Wei; Rice, James W.; Rodriguez, J.A.P.

2017-01-01

Morphological evidence for ancient channelized flows (fluvial and fluvial-like landforms) exists on the surfaces of all of the inner planets and on some of the satellites of the Solar System. In some cases, the relevant fluid flows are related to a planetary evolution that involves the global cycling of a volatile component (water for Earth and Mars; methane for Saturn’s moon Titan). In other cases, as on Mercury, Venus, Earth’s moon, and Jupiter’s moon Io, the flows were of highly fluid lava. The discovery, in 1972, of what are now known to be fluvial channels and valleys on Mars sparked a major controversy over the role of water in shaping the surface of that planet. The recognition of the fluvial character of these features has opened unresolved fundamental questions about the geological history of water on Mars, including the presence of an ancient ocean and the operation of a hydrological cycle during the earliest phases of planetary history. Other fundamental questions posed by fluvial and fluvial-like features on planetary bodies include the possible erosive action of large-scale outpourings of very fluid lavas, such as those that may have produced the remarkable canali forms on Venus; the ability of exotic fluids, such as methane, to create fluvial-like landforms, as observed on Saturn’s moon, Titan; and the nature of sedimentation and erosion under different conditions of planetary surface gravity. Planetary fluvial geomorphology also illustrates fundamental epistemological and methodological issues, including the role of analogy in geomorphological/geological inquiry. PMID:29176917

Is the Limit-Cycle-Attractor an (almost) invariable characteristic in human walking?

PubMed

Broscheid, Kim-Charline; Dettmers, Christian; Vieten, Manfred

2018-05-16

Common methods of gait analyses measure step length/width, gait velocity and gait variability to name just a few. Those parameters tend to be changing with fitness and skill of the subjects. But, do stable subject characteristic parameters in walking exist? Does the Limit-Cycle-Attractor qualify as such a parameter?. The attractor method is a new approach focusing on the dynamics of human motion. It classifies the fundamental walking pattern by calculating the Limit-Cycle-Attractor and its variability from acceleration data of the feet. Our hypothesis is that the fundamental walking pattern in healthy controls and in people with Multiple Sclerosis (pwMS) is stable, but can be altered through acute interventions or rehabilitation. For this purpose, two investigations were conducted involving 113 subjects. The short-term stability was tested pre and post a 15 min passive/active MOTOmed (ergometer) session as well as up to 20 min afterwards. The long-term stability was tested over five weeks of rehabilitation once a week in pwMS. The main parameter of interest describes the velocity normalized average difference between two attractors (δM), which is an indicator for the change in movement pattern. The Friedman's two-way ANOVA by ranks did not reveal any significant difference in δM. However, the conventional walking tests (6 min.10 m) improved significantly (p < 0.05) during rehabilitation. Contrary to our original hypothesis, the fundamental walking pattern was highly stable against controlled motor-assisted movement initiation via MOTOmed and rehabilitation treatment. Movement characteristics appeared to be independent of the improved fitness as indicated by the enhanced walking speed and distance. The individual Limit-Cycle-Attractor is extremely robust and might indeed qualify as an (almost) invariable characteristic in human walking. This opens up the possibility to encode the individual walking characteristics. Conditions as Parkinson, Multiple Sclerosis etc., might display disease specific distinctions via the Limit-Cycle-Attractor. Copyright © 2018 Elsevier B.V. All rights reserved.

Fundamental physics at the intensity frontier. Report of the workshop held December 2011 in Rockville, MD.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hewett, J.L.; Weerts, H.; Brock, R.

2012-06-05

Particle physics aims to understand the universe around us. The Standard Model of particle physics describes the basic structure of matter and forces, to the extent we have been able to probe thus far. However, it leaves some big questions unanswered. Some are within the Standard Model itself, such as why there are so many fundamental particles and why they have different masses. In other cases, the Standard Model simply fails to explain some phenomena, such as the observed matter-antimatter asymmetry in the universe, the existence of dark matter and dark energy, and the mechanism that reconciles gravity with quantummore » mechanics. These gaps lead us to conclude that the universe must contain new and unexplored elements of Nature. Most of particle and nuclear physics is directed towards discovering and understanding these new laws of physics. These questions are best pursued with a variety of approaches, rather than with a single experiment or technique. Particle physics uses three basic approaches, often characterized as exploration along the cosmic, energy, and intensity frontiers. Each employs different tools and techniques, but they ultimately address the same fundamental questions. This allows a multi-pronged approach where attacking basic questions from different angles furthers knowledge and provides deeper answers, so that the whole is more than a sum of the parts. A coherent picture or underlying theoretical model can more easily emerge, to be proven correct or not. The intensity frontier explores fundamental physics with intense sources and ultra-sensitive, sometimes massive detectors. It encompasses searches for extremely rare processes and for tiny deviations from Standard Model expectations. Intensity frontier experiments use precision measurements to probe quantum effects. They typically investigate very large energy scales, even higher than the kinematic reach of high energy particle accelerators. The science addresses basic questions, such as: Are there new sources of CP violation? Is there CP violation in the leptonic sector? Are neutrinos their own antiparticles? Do the forces unify? Is there a weakly coupled hidden sector that is related to dark matter? Do new symmetries exist at very high energy scales? To identify the most compelling science opportunities in this area, the workshop Fundamental Physics at the Intensity Frontier was held in December 2011, sponsored by the Office of High Energy Physics in the US Department of Energy Office of Science. Participants investigated the most promising experiments to exploit these opportunities and described the knowledge that can be gained from such a program. The workshop generated much interest in the community, as witnessed by the large and energetic participation by a broad spectrum of scientists. This document chronicles the activities of the workshop, with contributions by more than 450 authors. The workshop organized the intensity frontier science program along six topics that formed the basis for working groups: experiments that probe (i) heavy quarks, (ii) charged leptons, (iii) neutrinos, (iv) proton decay, (v) light, weakly interacting particles, and (vi) nucleons, nuclei, and atoms. The conveners for each working group included an experimenter and a theorist working in the field and an observer from the community at large. The working groups began their efforts well in advance of the workshop, holding regular meetings and soliciting written contributions. Specific avenues of exploration were identified by each working group. Experiments that study rare strange, charm, and bottom meson decays provide a broad program of measurements that are sensitive to new interactions. Charged leptons, particularly muons and taus, provide a precise probe for new physics because the Standard Model predictions for their properties are very accurate. Research at the intensity frontier can reveal CP violation in the lepton sector, and elucidate whether neutrinos are their own antiparticles. A very weakly coupled hidden-sector that may comprise the dark matter in the universe could be discovered. The search for proton decay can probe the unification of the forces with unprecedented reach and test sacrosanct symmetries to very high scales. Detecting an electric dipole moment for the neutron, or neutral atoms, could establish a clear signal for new physics, while limits on such a measurement would place severe constraints on many new theories. This workshop marked the first instance where discussion of these diverse programs was held under one roof. As a result, it was realized that this broad effort has many connections; a large degree of synergy exists between the different areas and they address similar questions. Results from one area were found to be pertinent to experiments in another domain.« less

The perception of complex tones by a false killer whale (Pseudorca crassidens).

PubMed

Yuen, Michelle M L; Nachtigall, Paul E; Breese, Marlee; Vlachos, Stephanie A

2007-03-01

Complex tonal whistles are frequently produced by some odontocete species. However, no experimental evidence exists regarding the detection of complex tones or the discrimination of harmonic frequencies by a marine mammal. The objectives of this investigation were to examine the ability of a false killer whale to discriminate pure tones from complex tones and to determine the minimum intensity level of a harmonic tone required for the whale to make the discrimination. The study was conducted with a go/no-go modified staircase procedure. The different stimuli were complex tones with a fundamental frequency of 5 kHz with one to five harmonic frequencies. The results from this complex tone discrimination task demonstrated: (1) that the false killer whale was able to discriminate a 5 kHz pure tone from a complex tone with up to five harmonics, and (2) that discrimination thresholds or minimum intensity levels exist for each harmonic combination measured. These results indicate that both frequency level and harmonic content may have contributed to the false killer whale's discrimination of complex tones.

Nanotechnology, resources, and pollution control

NASA Astrophysics Data System (ADS)

Gillett, Stephen L.

1996-09-01

The separation of different kinds of atoms or molecules from each other is a fundamental technological problem. Current techniques of resource extraction, which use the ancient paradigm of the differential partitioning of elements into coexisting phases, are simple but extremely wasteful and require feedstocks (`ores') that are already anomalously enriched. This is impractical for pollution control and desalination, which require extraction of low concentrations; instead, atomistic separation, typically by differential motion through semipermeable membranes, is used. The present application of such membranes is seriously limited, however, mostly because of limitations in their fabrication by conventional bulk techniques. The capabilities of biological systems, such as vertebrate kidneys, are vastly better, largely because they are intrinsically structured at a molecular scale. Nanofabrication of semipermeable membranes promises capabilities on the order of those of biological systems, and this in turn could provide much financial incentive for the development of molecular assemblers, as well established markets exist already. Continued incentives would exist, moreover, as markets expanded with decreasing costs, leading to such further applications as remediation of polluted sites, cheap desalination, and resource extraction from very low-grade sources.

The SHiP experiment at CERN

NASA Astrophysics Data System (ADS)

De Lellis, G.; SHiP Collaboration

2017-04-01

The discovery of the Higgs boson has fully confirmed the Standard Model of particles and fields. Nevertheless, there are still fundamental phenomena, like the existence of dark matter and the baryon asymmetry of the Universe, which deserve an explanation that could come from the discovery of new particles. Searches for new physics with accelerators are performed at the LHC, looking for high massive particles coupled to matter with ordinary strength. A new experiment at CERN meant to search for very weakly coupled particles in the few GeV mass domain has been recently proposed. The existence of such particles, foreseen in different theoretical models beyond the Standard Model, is largely unexplored. A beam dump facility using high intensity 400 GeV protons is a copious source of such unknown particles in the GeV mass range. The beam dump is also a copious source of neutrinos and in particular it is an ideal source of tau neutrinos, the less known particle in the Standard Model. Indeed, tau anti-neutrinos have not been directly observed so far. We report the physics potential of such an experiment.

The SHiP experiment at CERN

NASA Astrophysics Data System (ADS)

Bonivento, Walter M.

2017-07-01

The discovery of the Higgs boson has fully confirmed the Standard Model of particles and fields. Nevertheless, there are still fundamental phenomena, like the existence of dark matter and the baryon asymmetry of the Universe, deserving an explanation that could come from the discovery of new particles. Searches for new physics with accelerators are performed at the LHC, looking for high massive particles coupled to matter with ordinary strength. A new experiment at CERN meant to search for very weakly coupled particles in the few GeV mass domain has been recently proposed. The existence of such particles, foreseen in different theoretical models beyond the Standard Model, is largely unexplored. A beam dump facility using high intensity 400 GeV protons is a copious source of such unknown particles in the GeV mass range. The beam dump is also a copious source of neutrinos and in particular it is an ideal source of tau neutrinos, the less known particle in the Standard Model. The neutrino detector can also search for dark matter through its scattering off the electrons. We report the physics potential of the SHiP experiment.

Experimental and Numerical Study on Tensile Strength of Concrete under Different Strain Rates

PubMed Central

Min, Fanlu; Yao, Zhanhu; Jiang, Teng

2014-01-01

The dynamic characterization of concrete is fundamental to understand the material behavior in case of heavy earthquakes and dynamic events. The implementation of material constitutive law is of capital importance for the numerical simulation of the dynamic processes as those caused by earthquakes. Splitting tensile concrete specimens were tested at strain rates of 10−7 s−1 to 10−4 s−1 in an MTS material test machine. Results of tensile strength versus strain rate are presented and compared with compressive strength and existing models at similar strain rates. Dynamic increase factor versus strain rate curves for tensile strength were also evaluated and discussed. The same tensile data are compared with strength data using a thermodynamic model. Results of the tests show a significant strain rate sensitive behavior, exhibiting dynamic tensile strength increasing with strain rate. In the quasistatic strain rate regime, the existing models often underestimate the experimental results. The thermodynamic theory for the splitting tensile strength of concrete satisfactorily describes the experimental findings of strength as effect of strain rates. PMID:24883355

Female genital mutilation: a hidden epidemic (statement from the European Academy of Paediatrics).

PubMed

Sauer, Pieter J J; Neubauer, David

2014-02-01

Female genital mutilation or female circumcision is frequently performed worldwide. It is estimated by the World Health Organisation that worldwide, 100-140 million girls and women currently have to live with the consequences of female genital mutilation. The article argues that the tradition is one of the causes, while another four possible reasons for undergoing such cruel mutilation of young girls exist. Today, there exists a classification of at least four different ways of such mutilation which has no health benefits, and it harms girls and women in many ways. Long-term consequences like recurrent urinary tract infections, dysmenorrhea, sexual problems, infertility and complications both for the mother and infant at delivery are mentioned. Female genital mutilation is a violation of the fundamental human rights, as well as a savage breach of the integrity and personality. The European Academy of Paediatrics advises its members to initiate appropriate counselling for parents and female adolescents regarding the risk of female genital mutilation and strongly condemns female genital mutilation and councils its members not to perform such procedures.

Measuring the Complexity of Seismicity Pattern Evolution

NASA Astrophysics Data System (ADS)

Goltz, C.

2004-12-01

``Complexity'' has become an ubiquitous term in science. However, there is, much as with ``fractality'', no clear definition of what complexity actually means. Yet, it is important to distinguish between what is merely complicated and what is complex in the sense that simple rules can give rise to very rich behaviour. Seismicity is certainly a complicated phenomenon (difficult to understand) but simple models such as cellular automata indicate that earthquakes are truly complex. From the observational point of view, there exists the problem of quantification of complexity in real world seismicity patterns (in the absence of even a rigid definition of complexity). Such a measurement is desirable, however, not only for fundamental understanding but also for monitoring and possibly for prediction purposes. Maybe the most workable definitions of complexity exist in informatics, summarised under the topic of algorithmic complexity. Here, after introducing the concepts, I apply such measures of complexity to temporally evolving seismicity patterns from different geographic regions. Finally, I discuss the usefulness of the approach and discuss results in view of the occurrence of large earthquakes.

The B36/S125 "2x2" Life-Like Cellular Automaton

NASA Astrophysics Data System (ADS)

Johnston, Nathaniel

The B36/S125 (or "2x2") cellular automaton is one that takes place on a 2D square lattice much like Conway's Game of Life. Although it exhibits high-level behaviour that is similar to Life, such as chaotic but eventually stable evolution and the existence of a natural diagonal glider, the individual objects that the rule contains generally look very different from their Life counterparts. In this article, a history of notable discoveries in the 2x2 rule is provided, and the fundamental patterns of the automaton are described. Some theoretical results are derived along the way, including a proof that the speed limits for diagonal and orthogonal spaceships in this rule are c/3 and c/2, respectively. A Margolus block cellular automaton that 2x2 emulates is investigated, and in particular a family of oscillators made up entirely of 2×2 blocks are analyzed and used to show that there exist oscillators with period 2ℓ(2k-1) for any integers k,ℓ≥1.

Sensor-based auto-focusing system using multi-scale feature extraction and phase correlation matching.

PubMed

Jang, Jinbeum; Yoo, Yoonjong; Kim, Jongheon; Paik, Joonki

2015-03-10

This paper presents a novel auto-focusing system based on a CMOS sensor containing pixels with different phases. Robust extraction of features in a severely defocused image is the fundamental problem of a phase-difference auto-focusing system. In order to solve this problem, a multi-resolution feature extraction algorithm is proposed. Given the extracted features, the proposed auto-focusing system can provide the ideal focusing position using phase correlation matching. The proposed auto-focusing (AF) algorithm consists of four steps: (i) acquisition of left and right images using AF points in the region-of-interest; (ii) feature extraction in the left image under low illumination and out-of-focus blur; (iii) the generation of two feature images using the phase difference between the left and right images; and (iv) estimation of the phase shifting vector using phase correlation matching. Since the proposed system accurately estimates the phase difference in the out-of-focus blurred image under low illumination, it can provide faster, more robust auto focusing than existing systems.

Sensor-Based Auto-Focusing System Using Multi-Scale Feature Extraction and Phase Correlation Matching

PubMed Central

Jang, Jinbeum; Yoo, Yoonjong; Kim, Jongheon; Paik, Joonki

2015-01-01

This paper presents a novel auto-focusing system based on a CMOS sensor containing pixels with different phases. Robust extraction of features in a severely defocused image is the fundamental problem of a phase-difference auto-focusing system. In order to solve this problem, a multi-resolution feature extraction algorithm is proposed. Given the extracted features, the proposed auto-focusing system can provide the ideal focusing position using phase correlation matching. The proposed auto-focusing (AF) algorithm consists of four steps: (i) acquisition of left and right images using AF points in the region-of-interest; (ii) feature extraction in the left image under low illumination and out-of-focus blur; (iii) the generation of two feature images using the phase difference between the left and right images; and (iv) estimation of the phase shifting vector using phase correlation matching. Since the proposed system accurately estimates the phase difference in the out-of-focus blurred image under low illumination, it can provide faster, more robust auto focusing than existing systems. PMID:25763645

The influence of porosity and structural parameters on different kinds of gas hydrate dissociation

PubMed Central

Misyura, S. Y.

2016-01-01

Methane hydrate dissociation at negative temperatures was studied experimentally for different artificial and natural samples, differing by macro- and micro-structural parameters. Four characteristic dissociation types are discussed in the paper. The internal kinetics of artificial granule gas hydrates and clathrate hydrates in coal is dependent on the porosity, defectiveness and gas filtration rate. The density of pores distribution in the crust of formed ice decreases by the several orders of magnitude and this change significantly the rate of decay. Existing models for describing dissociation at negative temperatures do not take into account the structural parameters of samples. The dissociation is regulated by internal physical processes that must be considered in the simulation. Non-isothermal dissociation with constant external heat flux was simulated numerically. The dissociation is simulated with consideration of heat and mass transfer, kinetics of phase transformation and gas filtering through a porous medium of granules for the negative temperatures. It is shown that the gas hydrate dissociation in the presence of mainly microporous structures is fundamentally different from the disintegration of gas hydrates containing meso and macropores. PMID:27445113

Two Populations of Sunspots: Differential Rotation

NASA Astrophysics Data System (ADS)

Nagovitsyn, Yu. A.; Pevtsov, A. A.; Osipova, A. A.

2018-03-01

To investigate the differential rotation of sunspot groups using the Greenwich data, we propose an approach based on a statistical analysis of the histograms of particular longitudinal velocities in different latitude intervals. The general statistical velocity distributions for all such intervals are shown to be described by two rather than one normal distribution, so that two fundamental rotation modes exist simultaneously: fast and slow. The differentiality of rotation for the modes is the same: the coefficient at sin2 in Faye's law is 2.87-2.88 deg/day, while the equatorial rotation rates differ significantly, 0.27 deg/day. On the other hand, an analysis of the longitudinal velocities for the previously revealed two differing populations of sunspot groups has shown that small short-lived groups (SSGs) are associated with the fast rotation mode, while large long-lived groups (LLGs) are associated with both fast and slow modes. The results obtained not only suggest a real physical difference between the two populations of sunspots but also give new empirical data for the development of a dynamo theory, in particular, for the theory of a spatially distributed dynamo.

Ion Acoustic Wave Frequencies and Onset Times During Type 3 Solar Radio Bursts

NASA Technical Reports Server (NTRS)

Cairns, Iver H.; Robinson, P. A.

1995-01-01

Conflicting interpretations exist for the low-frequency ion acoustic (S) waves often observed by ISEE 3 in association with intense Langmuir (L) waves in the source regions of type III solar radio bursts near 1 AU. Two indirect lines of observational evidence, as well as plasma theory, suggest they are produced by the electrostatic (ES) decay L yields L(PRIME) + S. However, contrary to theoretical predictions, an existing analysis of the wave frequencies instead favors the electromagnetic (EM) decays L yields T + S, where T denotes an EM wave near the plasma frequency. This conflict is addressed here by comparing the observed wave frequencies and onset times with theoretical predictions for the ES and EM decays, calculated using the time-variable electron beam and magnetic field orientation data, rather than the nominal values used previously. Field orientation effects and beam speed variations are shown analytically to produce factor-of-three effects, greater than the difference in wave frequencies predicted for the ES and EM decays; effects of similar magnitude occur in the events analyzed here. The S-wave signals are extracted by hand from a sawtooth noise background, greatly improving the association between S waves and intense L waves. Very good agreement exists between the time-varying predictions for the ES decay and the frequencies of most (but not all) wave bursts. The waves occur only after the ES decay becomes kinematically allowed, which is consistent with the ES decay proceeding and producing most of the observed signals. Good agreement exists between the EM decay's predictions and a significant fraction of the S-wave observations while the EM decay is kinematically allowed. The wave data are not consistent, however, with the EM decay being the dominant nonlinear process. Often the observed waves are sufficiently broadband to overlap simultaneously the frequency ranges predicted for the ES and EM decays. Coupling the dominance of the ES decay with this frequency overlap provides support for a previous suggestion that fundamental emission occurs when the EM decay is stimulated by the ES decay product waves. The periods in which the ES and EM decays produce observable S waves are consistent with the observed and (independently) predicted times of fundamental and harmonic radio emission. This supports interpretation of fundamental emission as stimulated EM decay and harmonic emission as the coalescence L + L(prime) yields T of beam-generated L waves and L(prime) waves produced by the ES decay, where T denotes an electromagnetic wave at twice the plasma frequency. Analysis of the electron beam data reveals that the time-varying beam speed is consistent with ballistic beam propagation with minimal energy loss, implying that the beam propagates in a state close to time- and volume-averaged marginal stability. This confirms a central tenet of the stochastic growth theory for type III bursts.

Animal Welfare Policy: Implementation in the Context of Wildlife Research--Policy Review and Discussion of Fundamental Issues.

PubMed

Paul, Ellen; Sikes, Robert S; Beaupre, Steven J; Wingfield, John C

2016-01-01

The use of vertebrate animals in research and education in the United States is subject to a number of regulations, policies, and guidelines under the immediate oversight of Institutional Animal Care and Use Committees (IACUCs), which are charged with ensuring the ethical and appropriate use of the animal subjects. In almost all instances, this regulatory and oversight landscape of animal use has been developed around domesticated animals in biomedical research environments. When the research activities involve wild species, especially in their natural habitat rather than a laboratory, oversight personnel and investigators alike struggle with determining what constitutes ethical and appropriate activities. These difficulties stem from fundamental differences in biology between wild and domesticated animals and from the differences in research objectives and methods in wildlife compared with biomedical research. Here we discuss the various policies, regulations, and guidance documents for animal use in the context of wildlife research. We compare the expectations of the various oversight agencies and how these expectations are met when working with wild vertebrates. We make recommendations for how IACUCs can use available resources to ensure that activities involving wild species are conducted in compliance with existing regulations and policies and in ways that are biologically appropriate for these nondomesticated species. © The Author 2016. Published by Oxford University Press on behalf of the Institute for Laboratory Animal Research. All rights reserved. For permissions, please email: journals.permissions@oup.com.

Image feature detection and extraction techniques performance evaluation for development of panorama under different light conditions

NASA Astrophysics Data System (ADS)

Patil, Venkat P.; Gohatre, Umakant B.

2018-04-01

The technique of obtaining a wider field-of-view of an image to get high resolution integrated image is normally required for development of panorama of a photographic images or scene from a sequence of part of multiple views. There are various image stitching methods developed recently. For image stitching five basic steps are adopted stitching which are Feature detection and extraction, Image registration, computing homography, image warping and Blending. This paper provides review of some of the existing available image feature detection and extraction techniques and image stitching algorithms by categorizing them into several methods. For each category, the basic concepts are first described and later on the necessary modifications made to the fundamental concepts by different researchers are elaborated. This paper also highlights about the some of the fundamental techniques for the process of photographic image feature detection and extraction methods under various illumination conditions. The Importance of Image stitching is applicable in the various fields such as medical imaging, astrophotography and computer vision. For comparing performance evaluation of the techniques used for image features detection three methods are considered i.e. ORB, SURF, HESSIAN and time required for input images feature detection is measured. Results obtained finally concludes that for daylight condition, ORB algorithm found better due to the fact that less tome is required for more features extracted where as for images under night light condition it shows that SURF detector performs better than ORB/HESSIAN detectors.

Chondrules: The canonical and noncanonical views

NASA Astrophysics Data System (ADS)

Connolly, Harold C.; Jones, Rhian H.

2016-10-01

Millimeter-scale rock particles called chondrules are the principal components of the most common meteorites, chondrites. Hence, chondrules were arguably the most abundant components of the early solar system at the time of planetesimal accretion. Despite their fundamental importance, the existence of chondrules would not be predicted from current observations and models of young planetary systems. There are many different models for chondrule formation, but no single model satisfies the many constraints determined from their mineralogical and chemical properties and from chondrule analog experiments. Significant recent progress has shown that several models can satisfy first-order constraints and successfully reproduce chondrule thermal histories. However, second- and third-order constraints such as chondrule size ranges, open system behavior, oxidation states, reheating, and chemical diversity have not generally been addressed. Chondrule formation models include those based on processes that are known to occur in protoplanetary disk environments, including interactions with the early active Sun, impacts and collisions between planetary bodies, and radiative heating. Other models for chondrule heating mechanisms are based on hypothetical processes that are possible but have not been observed, like shock waves, planetesimal bow shocks, and lightning. We examine the evidence for the canonical view of chondrule formation, in which chondrules were free-floating particles in the protoplanetary disk, and the noncanonical view, in which chondrules were the by-products of planetesimal formation. The fundamental difference between these approaches has a bearing on the importance of chondrules during planet formation and the relevance of chondrules to interpreting the evolution of protoplanetary disks and planetary systems.

Covariant Structure of Models of Geophysical Fluid Motion

NASA Astrophysics Data System (ADS)

Dubos, Thomas

2018-01-01

Geophysical models approximate classical fluid motion in rotating frames. Even accurate approximations can have profound consequences, such as the loss of inertial frames. If geophysical fluid dynamics are not strictly equivalent to Newtonian hydrodynamics observed in a rotating frame, what kind of dynamics are they? We aim to clarify fundamental similarities and differences between relativistic, Newtonian, and geophysical hydrodynamics, using variational and covariant formulations as tools to shed the necessary light. A space-time variational principle for the motion of a perfect fluid is introduced. The geophysical action is interpreted as a synchronous limit of the relativistic action. The relativistic Levi-Civita connection also has a finite synchronous limit, which provides a connection with which to endow geophysical space-time, generalizing Cartan (1923). A covariant mass-momentum budget is obtained using covariance of the action and metric-preserving properties of the connection. Ultimately, geophysical models are found to differ from the standard compressible Euler model only by a specific choice of a metric-Coriolis-geopotential tensor akin to the relativistic space-time metric. Once this choice is made, the same covariant mass-momentum budget applies to Newtonian and all geophysical hydrodynamics, including those models lacking an inertial frame. Hence, it is argued that this mass-momentum budget provides an appropriate, common fundamental principle of dynamics. The postulate that Euclidean, inertial frames exist can then be regarded as part of the Newtonian theory of gravitation, which some models of geophysical hydrodynamics slightly violate.

The origins of the universe: why is there something rather than nothing?

PubMed

Paulson, Steve; Albert, David; Holt, Jim; Turok, Neil

2015-12-01

Perhaps the greatest mystery is why the universe exists in the first place. How is it possible for something to emerge from nothing, or has a universe in some form always existed? This question of origins-both of the universe as a whole and of the fundamental laws of physics-raises profound scientific, philosophical, and religious questions, culminating in the most basic existential question of all: Why are we here? Discussion of this and related questions is presented in this paper. © 2015 New York Academy of Sciences.

A Valid Demonstration of the Missing Fundamental Illusion.

ERIC Educational Resources Information Center

Larsen, Janet D.; Fritsch, Klaus

1998-01-01

Identifies the "missing fundamental illusion" as that which occurs when two tones are heard together and the listener hears a third tone with a pitch corresponding to the difference in their frequencies. Describes an inexpensive and valid demonstration of the missing fundamental using a British police whistle. (MJP)

Women Favour Dyadic Relationships, but Men Prefer Clubs: Cross-Cultural Evidence from Social Networking

PubMed Central

David-Barrett, Tamas; Rotkirch, Anna; Carney, James; Behncke Izquierdo, Isabel; Krems, Jaimie A.; Townley, Dylan; McDaniell, Elinor; Byrne-Smith, Anna; Dunbar, Robin I. M.

2015-01-01

The ability to create lasting, trust-based friendships makes it possible for humans to form large and coherent groups. The recent literature on the evolution of sociality and on the network dynamics of human societies suggests that large human groups have a layered structure generated by emotionally supported social relationships. There are also gender differences in adult social style which may involve different trade-offs between the quantity and quality of friendships. Although many have suggested that females tend to focus on intimate relations with a few other females, while males build larger, more hierarchical coalitions, the existence of such gender differences is disputed and data from adults is scarce. Here, we present cross-cultural evidence for gender differences in the preference for close friendships. We use a sample of ∼112,000 profile pictures from nine world regions posted on a popular social networking site to show that, in self-selected displays of social relationships, women favour dyadic relations, whereas men favour larger, all-male cliques. These apparently different solutions to quality-quantity trade-offs suggest a universal and fundamental difference in the function of close friendships for the two sexes. PMID:25775258

Women favour dyadic relationships, but men prefer clubs: cross-cultural evidence from social networking.

PubMed

David-Barrett, Tamas; Rotkirch, Anna; Carney, James; Behncke Izquierdo, Isabel; Krems, Jaimie A; Townley, Dylan; McDaniell, Elinor; Byrne-Smith, Anna; Dunbar, Robin I M

2015-01-01

The ability to create lasting, trust-based friendships makes it possible for humans to form large and coherent groups. The recent literature on the evolution of sociality and on the network dynamics of human societies suggests that large human groups have a layered structure generated by emotionally supported social relationships. There are also gender differences in adult social style which may involve different trade-offs between the quantity and quality of friendships. Although many have suggested that females tend to focus on intimate relations with a few other females, while males build larger, more hierarchical coalitions, the existence of such gender differences is disputed and data from adults is scarce. Here, we present cross-cultural evidence for gender differences in the preference for close friendships. We use a sample of ∼112,000 profile pictures from nine world regions posted on a popular social networking site to show that, in self-selected displays of social relationships, women favour dyadic relations, whereas men favour larger, all-male cliques. These apparently different solutions to quality-quantity trade-offs suggest a universal and fundamental difference in the function of close friendships for the two sexes.

TarPmiR: a new approach for microRNA target site prediction.

PubMed

Ding, Jun; Li, Xiaoman; Hu, Haiyan

2016-09-15

The identification of microRNA (miRNA) target sites is fundamentally important for studying gene regulation. There are dozens of computational methods available for miRNA target site prediction. Despite their existence, we still cannot reliably identify miRNA target sites, partially due to our limited understanding of the characteristics of miRNA target sites. The recently published CLASH (crosslinking ligation and sequencing of hybrids) data provide an unprecedented opportunity to study the characteristics of miRNA target sites and improve miRNA target site prediction methods. Applying four different machine learning approaches to the CLASH data, we identified seven new features of miRNA target sites. Combining these new features with those commonly used by existing miRNA target prediction algorithms, we developed an approach called TarPmiR for miRNA target site prediction. Testing on two human and one mouse non-CLASH datasets, we showed that TarPmiR predicted more than 74.2% of true miRNA target sites in each dataset. Compared with three existing approaches, we demonstrated that TarPmiR is superior to these existing approaches in terms of better recall and better precision. The TarPmiR software is freely available at http://hulab.ucf.edu/research/projects/miRNA/TarPmiR/ CONTACTS: haihu@cs.ucf.edu or xiaoman@mail.ucf.edu Supplementary data are available at Bioinformatics online. © The Author 2016. Published by Oxford University Press.

The Model of Complex Structure of Quark

NASA Astrophysics Data System (ADS)

Liu, Rongwu

2017-09-01

In Quantum Chromodynamics, quark is known as a kind of point-like fundamental particle which carries mass, charge, color, and flavor, strong interaction takes place between quarks by means of exchanging intermediate particles-gluons. An important consequence of this theory is that, strong interaction is a kind of short-range force, and it has the features of ``asymptotic freedom'' and ``quark confinement''. In order to reveal the nature of strong interaction, the ``bag'' model of vacuum and the ``string'' model of string theory were proposed in the context of quantum mechanics, but neither of them can provide a clear interaction mechanism. This article formulates a new mechanism by proposing a model of complex structure of quark, it can be outlined as follows: (1) Quark (as well as electron, etc) is a kind of complex structure, it is composed of fundamental particle (fundamental matter mass and electricity) and fundamental volume field (fundamental matter flavor and color) which exists in the form of limited volume; fundamental particle lies in the center of fundamental volume field, forms the ``nucleus'' of quark. (2) As static electric force, the color field force between quarks has classical form, it is proportional to the square of the color quantity carried by each color field, and inversely proportional to the area of cross section of overlapping color fields which is along force direction, it has the properties of overlap, saturation, non-central, and constant. (3) Any volume field undergoes deformation when interacting with other volume field, the deformation force follows Hooke's law. (4) The phenomena of ``asymptotic freedom'' and ``quark confinement'' are the result of color field force and deformation force.

Requirements for implementing real-time control functional modules on a hierarchical parallel pipelined system

NASA Technical Reports Server (NTRS)

Wheatley, Thomas E.; Michaloski, John L.; Lumia, Ronald

1989-01-01

Analysis of a robot control system leads to a broad range of processing requirements. One fundamental requirement of a robot control system is the necessity of a microcomputer system in order to provide sufficient processing capability.The use of multiple processors in a parallel architecture is beneficial for a number of reasons, including better cost performance, modular growth, increased reliability through replication, and flexibility for testing alternate control strategies via different partitioning. A survey of the progression from low level control synchronizing primitives to higher level communication tools is presented. The system communication and control mechanisms of existing robot control systems are compared to the hierarchical control model. The impact of this design methodology on the current robot control systems is explored.

Species-barrier-independent prion replication in apparently resistant species

NASA Astrophysics Data System (ADS)

Hill, Andrew F.; Joiner, Susan; Linehan, Jackie; Desbruslais, Melanie; Lantos, Peter L.; Collinge, John

2000-08-01

Transmission of prions between mammalian species is thought to be limited by a "species barrier," which depends on differences in the primary structure of prion proteins in the infecting inoculum and the host. Here we demonstrate that a strain of hamster prions thought to be nonpathogenic for conventional mice leads to prion replication to high levels in such mice but without causing clinical disease. Prions pathogenic in both mice and hamsters are produced. These results demonstrate the existence of subclinical forms of prion infection with important public health implications, both with respect to iatrogenic transmission from apparently healthy humans and dietary exposure to cattle and other species exposed to bovine spongiform encephalopathy prions. Current definitions of the species barrier, which have been based on clinical end-points, need to be fundamentally reassessed.

FPGA-based coprocessor for matrix algorithms implementation

NASA Astrophysics Data System (ADS)

Amira, Abbes; Bensaali, Faycal

2003-03-01

Matrix algorithms are important in many types of applications including image and signal processing. These areas require enormous computing power. A close examination of the algorithms used in these, and related, applications reveals that many of the fundamental actions involve matrix operations such as matrix multiplication which is of O (N3) on a sequential computer and O (N3/p) on a parallel system with p processors complexity. This paper presents an investigation into the design and implementation of different matrix algorithms such as matrix operations, matrix transforms and matrix decompositions using an FPGA based environment. Solutions for the problem of processing large matrices have been proposed. The proposed system architectures are scalable, modular and require less area and time complexity with reduced latency when compared with existing structures.

OASYS: a computerized auditing system for orthopaedic surgery.

PubMed

Stoodley, M A; Sikorski, J M

1991-11-01

Medical auditing based on individual diagnoses or specific therapies is well established. Auditing of all medical activity has an expanding role in quality assurance and research. In an attempt to overcome the limitations of existing auditing systems, a fundamentally different, flexible, high quality and easily accessible orthopaedic auditing system has been developed. This records a description of each component of patients' orthopaedic diagnoses, records treatment and complications, produces discharge letters and surgical log books and allows flexible and comprehensive audits. It has been in use in an orthopaedic service since January 1990 and has been successful in identifying problems and monitoring the effectiveness of changes. It is anticipated that the system will become more widely used and provide the basis for a 'user group' which will share the accumulated data and further development costs.

FOURTH SEMINAR TO THE MEMORY OF D.N. KLYSHKO: Algebraic solution of the synthesis problem for coded sequences

NASA Astrophysics Data System (ADS)

Leukhin, Anatolii N.

2005-08-01

The algebraic solution of a 'complex' problem of synthesis of phase-coded (PC) sequences with the zero level of side lobes of the cyclic autocorrelation function (ACF) is proposed. It is shown that the solution of the synthesis problem is connected with the existence of difference sets for a given code dimension. The problem of estimating the number of possible code combinations for a given code dimension is solved. It is pointed out that the problem of synthesis of PC sequences is related to the fundamental problems of discrete mathematics and, first of all, to a number of combinatorial problems, which can be solved, as the number factorisation problem, by algebraic methods by using the theory of Galois fields and groups.

International financial institutions and health in Egypt and Tunisia: change or continuity?

PubMed

Ismail, Sharif

2013-01-01

The revolutions in Egypt and Tunisia appeared to herald a re-casting of International Monetary Fund and World Bank policy across the region. Public pronouncements by the heads of both institutions in the months following February 2011 acknowledged flaws in their approach to macroeconomic advice, against a background of worsening socioeconomic indicators, widespread youth unemployment, and widening health inequalities. Evidence on the ground, however, suggests continuity rather than change in international financial institution policies in Egypt and Tunisia, notwithstanding the emergence of a powerful new player-the European Bank for Reconstruction and Development. In the long term, new electoral realities and hardening public opposition in both countries seem likely to force a fundamentally different relationship between regional governments and the major international financial institutions than existed before 2011.

Design and Implementation of 13 Levels Multilevel Inverter for Photovoltaic System

NASA Astrophysics Data System (ADS)

Subramani, C.; Dhineshkumar, K.; Palanivel, P.

2018-04-01

This paper approaches the appearing and modernization of S-Type PV based 13- level multilevel inverter with less quantity of switch. The current S-Type Multi level inverter contains more number of switches and voltage sources. Multilevel level inverter is a be understandable among the most gainful power converters for high power application and present day applications with reduced switches. The fundamental good arrangement of the 13-level multilevel inverter is to get ventured voltage from a couple of levels of DC voltages.. The controller gives actual way day and age to switches through driver circuit using PWM methodology. The execution assessment of proposed multilevel inverter is checked using MATLAB/Simulink. This is the outstanding among other techniquem appeared differently in relation to all other existing system

Measuring routine nursing service efficiency: a comparison of cost per patient day and data envelopment analysis models.

PubMed Central

Nunamaker, T R

1983-01-01

This article provides an illustrative application of Data Envelopment Analysis (DEA) methodology to the measurement of routine nursing service efficiency at a group of Wisconsin hospitals. The DEA efficiency ratings and cost savings estimates are then compared to those resulting from application of Medicare's routine cost limitation to the sample data. DEA is also used to determine if any changes in the potential for efficient operations occurred during the 1978-1979 period. Empirical results were representative of the fundamental differences existing between the DEA and cost per patient day approaches. No evidence was found to support the notion that the overall potential for efficient delivery of routine services by the sample institutions was greater in one year than another. PMID:6874357

The impact of iterated games on traffic flow at noncontrolled intersections

NASA Astrophysics Data System (ADS)

Zhao, Chao; Jia, Ning

2015-05-01

Intersections without signal control widely exist in urban road networks. This paper studied the traffic flow in a noncontrolled intersection within an iterated game framework. We assume drivers have learning ability and can repetitively adjust their strategies (to give way or to rush through) in the intersection according to memories. A cellular automata model is applied to investigate the characteristics of the traffic flow. Numerical experiments indicate two main findings. First, the traffic flow experiences a "volcano-shaped" fundamental diagram with three different phases. Second, most drivers choose to give way in the intersection, but the aggressive drivers cannot be completely eliminated, which is coincident with field observations. Analysis are also given out to explain the observed phenomena. These findings allow deeper insight of the real-world bottleneck traffic flow.

The History of Optical Analysis of Milk: The Development and Use of Lactoscopes

NASA Astrophysics Data System (ADS)

Millan-Verdú, C.; Garrigós-Oltra, Ll.; Blanes-Nadal, G.; Domingo-Beltrán, M.

2003-07-01

The 19th century use of optical methods to detect the fraudulent adulteration of milk (by means of adding water) is presented in this article. The development and use of these optical methods was based on the principle of diaphanometry and illustrates the conflict that existed between two different approaches to scientific knowledge at that time. On the one hand, there were physicians who were more concerned with the practicality of the methods than on their accuracy; on the other hand, there were physicists who were fundamentally more interested in the accuracy of the results than the practicality of its use. This paper examines that conflict by analyzing the original lactoscope of Alfred Donné and the history of subsequent developments of the lactoscope.

Efficient solution for finding Hamilton cycles in undirected graphs.

PubMed

Alhalabi, Wadee; Kitanneh, Omar; Alharbi, Amira; Balfakih, Zain; Sarirete, Akila

2016-01-01

The Hamilton cycle problem is closely related to a series of famous problems and puzzles (traveling salesman problem, Icosian game) and, due to the fact that it is NP-complete, it was extensively studied with different algorithms to solve it. The most efficient algorithm is not known. In this paper, a necessary condition for an arbitrary un-directed graph to have Hamilton cycle is proposed. Based on this condition, a mathematical solution for this problem is developed and several proofs and an algorithmic approach are introduced. The algorithm is successfully implemented on many Hamiltonian and non-Hamiltonian graphs. This provides a new effective approach to solve a problem that is fundamental in graph theory and can influence the manner in which the existing applications are used and improved.

LASER APPLICATIONS AND OTHER TOPICS IN QUANTUM ELECTRONICS: An optical boiler generating singlet oxygen O2 (a1Δg)

NASA Astrophysics Data System (ADS)

Lipatov, N. I.; Biryukov, A. S.; Gulyamova, E. S.

2008-12-01

An ecologically perfect generator of singlet oxygen O2 (a1Δg) is proposed which fundamentally differs from existing singlet-oxygen generators. Excited O2 (a1Δg) molecules are generated due to interaction of the O2 (X3Σ-g) molecules with a quasi-monochromatic field, which is supplied from an external source to a closed volume — an optical boiler containing oxygen. It is shown that, by pumping continuously the optical boiler by the light field of power ~3×105 W, it is possible to accumulate up to 40% of singlet oxygen (O2(b1Σ+g)) + (O2 (a1Δg)) in the boiler volume during ~10-2 s.

Matrix isolation infrared and Raman spectra of binary and mixed group II B fluorides

NASA Astrophysics Data System (ADS)

Givan, A.; Loewenschuss, A.

1980-03-01

Infrared and Raman spectra of all MF2 and MFX molecules (M=Zn, Cd, Hg; X=Cl, Br) and the infrared spectrum of the fluoroidide HgFI isolated in solid krypton at 20 °K are reported. The MFX species were formed in a vapor mixture of the appropriate MF2 and MX2 dihalides, vaporized, at different temperatures, from separate compartments of a double-oven crucible. The spectra are the first experimental evidence for the existence of the molecular fluorohalides. All three fundamentals of the MF2 molecules and the two stretching mode frequencies of the MFX molecules are assigned. Harmonic force constants are evaluated and isotope effects are used to discuss their geometry. Thermodynamic functions are tabulated for the binary difluorides.

On the nature of the baryon asymmetry

NASA Technical Reports Server (NTRS)

Stecker, F. W.

1984-01-01

Whether the baryon asymmetry in the universe is a locally varying or universally fixed number is examined with focus on the existence of a possible matter antimatter domain structure in the universe arising from a GUT with spontaneous CP symmetry breaking. Theoretical considerations and observational data and astrophysical tests relating to this fundamental question are reviewed.

Moral Psychology Is Relationship Regulation: Moral Motives for Unity, Hierarchy, Equality, and Proportionality

ERIC Educational Resources Information Center

Rai, Tage Shakti; Fiske, Alan Page

2011-01-01

Genuine moral disagreement exists and is widespread. To understand such disagreement, we must examine the basic kinds of social relationships people construct across cultures and the distinct moral obligations and prohibitions these relationships entail. We extend relational models theory (Fiske, 1991) to identify 4 fundamental and distinct moral…

Determination of a Predictive Model for the Fundamentals of Engineering Examination

ERIC Educational Resources Information Center

Wheeler, Edward W.

2012-01-01

In early 1995, the University of Tennessee at Martin (UTM) sought permission to terminate three existing engineering technology degree programs and replace them with a single Bachelor of Science in Engineering (BSE) degree. As part of the requirements to proceed with the implementation of an engineering program, the University of Tennessee system…

Grammar Is Back, but When Will We Start Cooking?

ERIC Educational Resources Information Center

Vavra, Ed

2003-01-01

Suggests that the current "return" to grammar will fail unless educators can come to terms with definitions of fundamental grammatical concepts. Considers how educators cannot go back to teaching the traditional, because the traditional no longer exists. Argues that pedagogical grammar currently has too many cooks, all trying to prepare the same…

The Problem of Absolute Knowledge. Metaphysics as Intellectual Intuition in Classic Modern European Philosophy

ERIC Educational Resources Information Center

Torubarova, Tatyana V.

2016-01-01

Classic modern European philosophy explicate, reflect; leaving own history in fundamental metaphysical position, where the existence is understood as conscience. This position is representative in the process of historic development, transition of philosophical thought from R. Dekart to G. Hegel. It appears exactly the field of key metaphysical…

Toward a Theory of Coaching Paradox

ERIC Educational Resources Information Center

Barnson, Steven C.

2014-01-01

Multiple tensions exist as part of the coaching process. How a coach responds to these tensions is a fundamental determinant of an athlete or team's fate. In today's highly competitive, socially demanding, and ever-changing sports environment, and as the expectations on coaches become more complex, the paradox becomes a critical lens to…

78 FR 53761 - Federal Acquisition Regulation; Submission for OMB Review; Commercial Item Acquisitions

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-30

... Management and Budget (OMB) a request to review and approve an extension of a previously approved information... exists; however, its functionality is incorporated into the System for Award Management (SAM). B... fundamental purposes of the Paperwork Reduction Act because of the burden it puts on the entity submitting the...

Disposal of Information Seeking and Retrieval Research: Replacement with a Radical Proposition

ERIC Educational Resources Information Center

Budd, John M.; Anstaett, Ashley

2013-01-01

Introduction: Research and theory on the topics of information seeking and retrieval have been plagued by some fundamental problems for several decades. Many of the difficulties spring from mechanistic and instrumental thinking and modelling. Method: Existing models of information retrieval and information seeking are examined for efficacy in a…

"Use-It-or-Lose-It"? Interrogating an Educational Message from Teen Brain Research

ERIC Educational Resources Information Center

Payne, Monica A.

2010-01-01

Recent neuroimaging research has encouraged a fundamental shift in psychological thinking about cognitive development in adolescence. Challenging the existing view that early childhood was the most critical period for intellectually hard-wiring the brain, findings led researchers to speculate that early adolescence might be the more important…

Rethinking Creativity: Present in Expression in Creative Learning Communities

ERIC Educational Resources Information Center

Hwang, Soon Ye

2017-01-01

Often defined as originality and innovation and desired for the economic profits it can produce for both individuals and their societies, creativity has been examined in order to find ways in which it can be promoted through various instructional practices in and beyond schools. Nonetheless, creativity as a fundamental basis of human existence and…

1 CFR 457.150 - Program accessibility: Existing facilities.

Code of Federal Regulations, 2010 CFR

2010-01-01

... BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE NATIONAL CAPITAL PLANNING COMMISSION § 457... activity so that the program or activity, when viewed in its entirety, is readily accessible to and usable... can demonstrate would result in a fundamental alteration in the nature of a program or activity or in...

Using sampling theory as the basis for a conceptual data model

Treesearch

Fred C. Martin; Tonya Baggett; Tom Wolfe

2000-01-01

Greater demands on forest resources require that larger amounts of information be readily available to decisionmakers. To provide more information faster, databases must be developed that are more comprehensive and easier to use. Data modeling is a process for building more complete and flexible databases by emphasizing fundamental relationships over existing or...

Development and Evaluation of a Chemistry-Specific Version of the Academic Motivation Scale (AMS-Chemistry)

ERIC Educational Resources Information Center

Liu, Yujuan; Ferrell, Brent; Barbera, Jack; Lewis, Jennifer E.

2017-01-01

Fundamentally concerned with motivation, self-determination theory (SDT) represents a framework of several mini-theories to explore how social context interacts with people's motivational types categorized by degree of regulation internalization. This paper aims to modify an existing theory-based instrument (Academic Motivation Scale, or AMS) and…

Students' Preconceptions about Urban Environmental Problems and Solid Waste.

ERIC Educational Resources Information Center

Membiela, Pedro; And Others

1993-01-01

Examined students' preconceptions about environmental problems in cities, particularly that of urban disposable waste. They found that students' ideas were dominated by what they perceived, without regard to existing interactions, and that students were unaware of the fundamental role of reuse and recycling in the solution of the disposal of solid…

Teaching about Religion in History Classes: Sacred and Secular History.

ERIC Educational Resources Information Center

Abrahamson, Brant; Smith, Fred

In teaching about religion there is the fundamental distinction between secular history, which is restricted to natural cause and effect relationships, and sacred histories, which assume that a spirit world exists and that human/divine interaction has taken place. In the United States, the academically approved way of dealing with these…

Exploring the Wealth Returns to Latino Higher Educational Attainment: Estimates of Work-Life Earnings Profiles

ERIC Educational Resources Information Center

Robles, Barbara J.

2009-01-01

A significant research gap exists in our knowledge of how educational attainment affects wealth building and intergenerational wealth transfers among Latinos. Wealth includes earnings but is a much wider and more fundamental measure of economic mobility. The education-earnings-wealth relationship is explored by constructing estimates of social…

Beyond Abstinence-Only: Relationships between Abstinence Education and Comprehensive Topic Instruction

ERIC Educational Resources Information Center

Jeffries, William L., IV; Dodge, Brian; Bandiera, Frank C.; Reece, Michael

2010-01-01

In the United States, a debate exists as to whether abstinence-only or comprehensive sexuality education strategies are most beneficial for school-age youth. Despite abstinence being a fundamental component of comprehensive education, the two are often characterized as polar opposites. Few studies have examined overlaps between the approaches. The…

Practical Tools for Designing and Weighting Survey Samples

ERIC Educational Resources Information Center

Valliant, Richard; Dever, Jill A.; Kreuter, Frauke

2013-01-01

Survey sampling is fundamentally an applied field. The goal in this book is to put an array of tools at the fingertips of practitioners by explaining approaches long used by survey statisticians, illustrating how existing software can be used to solve survey problems, and developing some specialized software where needed. This book serves at least…

On the Fundamental Cause of River Meanders

NASA Astrophysics Data System (ADS)

Sahagian, D. L.; Diplas, P.

2017-12-01

River meandering has been attributed to the erosion and deposition of sediments along river banks, yet the fundamental cause of the instability has not been heretofore identified. In this conceptual study, we address the conditions that lead to the meander instability, in effect "upstream" of the many previous and thorough analyses of hydraulics and the alternating erosional/depositional pattern that ensues once such conditions exist. Rivers are only one of many fluid systems that exhibit meandering behavior, and no other involves sediments at all. Other examples include the gulf stream, glacial meltwater, the jet stream, channels in submarine fans, water falling directly down from a faucet, derailed trains and even tractor trailer trucks. As such, a universal criterion is needed to explain meandering in general. We show that meandering in all systems is driven by the existence of an adverse pressure gradient, such that the resulting deceleration imposed upon the fluid causes it to be energetically favorable to divert the flow to either side of its original direction. This universal framework makes it possible to determine under what conditions the meandering instability will be manifest in altered flow/channel morphology.

[Social participation and community orientation in health services].

PubMed

Martín-García, Manuel; Ponte-Mittelbrun, Carlos; Sánchez-Bayle, Marciano

2006-03-01

The community participation in the health systems is a concept that develops from the health policy proposals that have led the World Health Organization and that they highlight the fundamental role of health promotion and of primary care to answer to the health challenges from the middle of the XXth century. Its development has encountered big obstacles that have become major from the increasing trend of introduction of healthcare marketing. This explains partly its scanty advance in the developed countries, though there exist very interesting experiences that are based especially on the effort of professionals and social organizations. The fundamental dilemma is one in the option among the assumption of the role like consumers or clients that it supports a relation subordinated of the patients with a major dependence of the consumption, or on the contrary to give voice and vote for the citizens incorporating them into the productive process and turning them into producers of health. There are analyzed also the existing practices of community participation in Spain and offers are realized for its impulse and development.

Wavelength shifting of intra-cavity photons: Adiabatic wavelength tuning in rapidly wavelength-swept lasers

PubMed Central

Jirauschek, Christian; Huber, Robert

2015-01-01

We analyze the physics behind the newest generation of rapidly wavelength tunable sources for optical coherence tomography (OCT), retaining a single longitudinal cavity mode during operation without repeated build up of lasing. In this context, we theoretically investigate the currently existing concepts of rapidly wavelength-swept lasers based on tuning of the cavity length or refractive index, leading to an altered optical path length inside the resonator. Specifically, we consider vertical-cavity surface-emitting lasers (VCSELs) with microelectromechanical system (MEMS) mirrors as well as Fourier domain mode-locked (FDML) and Vernier-tuned distributed Bragg reflector (VT-DBR) lasers. Based on heuristic arguments and exact analytical solutions of Maxwell’s equations for a fundamental laser resonator model, we show that adiabatic wavelength tuning is achieved, i.e., hopping between cavity modes associated with a repeated build up of lasing is avoided, and the photon number is conserved. As a consequence, no fundamental limit exists for the wavelength tuning speed, in principle enabling wide-range wavelength sweeps at arbitrary tuning speeds with narrow instantaneous linewidth. PMID:26203373

Wearable sensors: modalities, challenges, and prospects.

PubMed

Heikenfeld, J; Jajack, A; Rogers, J; Gutruf, P; Tian, L; Pan, T; Li, R; Khine, M; Kim, J; Wang, J; Kim, J

2018-01-16

Wearable sensors have recently seen a large increase in both research and commercialization. However, success in wearable sensors has been a mix of both progress and setbacks. Most of commercial progress has been in smart adaptation of existing mechanical, electrical and optical methods of measuring the body. This adaptation has involved innovations in how to miniaturize sensing technologies, how to make them conformal and flexible, and in the development of companion software that increases the value of the measured data. However, chemical sensing modalities have experienced greater challenges in commercial adoption, especially for non-invasive chemical sensors. There have also been significant challenges in making significant fundamental improvements to existing mechanical, electrical, and optical sensing modalities, especially in improving their specificity of detection. Many of these challenges can be understood by appreciating the body's surface (skin) as more of an information barrier than as an information source. With a deeper understanding of the fundamental challenges faced for wearable sensors and of the state-of-the-art for wearable sensor technology, the roadmap becomes clearer for creating the next generation of innovations and breakthroughs.

Fundamental Solution For The Self-healing Fracture Pulse

NASA Astrophysics Data System (ADS)

Nielsen, S.; Madariaga, R.

We find the analytical solution for a fundamental fracture mode in the form of a self- similar, self-healing pulse. The existence of such a fracture mode was strongly sug- gested by recent numerical findings but, to our knwledge, no formal proof had been proposed up to date. We present a two dimensional, anti-plane solution for fixed rup- ture and healing velocities, that satisfies both wave equation and stress conditions; we argue that such a solution is plausible even in the absence of rate-weakening in the friction, as an alternative to the classic crack solution. In practice, the impulsive mode rather than the expanding crack mode is selected depending on details of fracture initiation, and is therafter self-maintained. We discuss stress concentration, fracture energy, rupture velocity and compare them to the case of a crack. The analytical study is complemented by various numerical examples and comparisons. On more general grounds, we argue that an infinity of marginally stable fracture modes may exist other than the crack solution or the impulseive fracture described here.

Soft bio-integrated systems for continuous health monitoring

NASA Astrophysics Data System (ADS)

Raj, M.; Wei, P. H.; Morey, B.; Wang, X.; Keen, B.; DePetrillo, P.; Hsu, Y. Y.; Ghaffari, R.

2014-06-01

Electronically-enabled wearable systems that monitor physiological activity and electrophysiological activity hold the key to truly personalized medical care outside of the hospital setting. However, fundamental technical challenges exist in achieving medical systems that are comfortable, unobtrusive and fully integrated without external connections to bench top instruments. In particular, there is a fundamental mismatch in mechanical coupling between existing classes of rigid electronics and soft biological substrates, like the skin. Here we describe new mechanical and electrical design strategies for wearable devices with mechanical properties that approach that of biological tissue. These systems exploit stretchable networks of conformal sensors (i.e. electrodes, temperature sensors, and accelerometers) and associated circuitry (i.e. microcontroller, memory, voltage regulators, rechargeable battery, wireless communication modules) embedded in ultrathin, elastomeric substrates. Quantitative analyses of sensor performance and mechanics under tensile and torsional stresses illustrate the ability to mechanically couple with soft tissues in a way that is mechanically invisible to the user. Representative examples of these soft biointegrated systems can be applied for continuous sensing of muscle and movement activity in the home and ambulatory settings.

Emerging Science and Research Opportunities for Metals and Metallic Nanostructures: A Report on the NSF MMN Workshop

NASA Astrophysics Data System (ADS)

Pollock, Tresa; Handwerker, Carol

In the next decade, fundamental research in metals and metallic nanostructures (MMN) has the potential to continue to transform science into innovative materials, devices, and systems. This talk summarizes the findings of a workshop to identify emerging and potentially transformative research areas in MMN. The metals and metallic nanostructures (MMNs) workshop aimed to identify significant research trends, scientific fundamentals, and recent breakthroughs that can enable new or enhanced MMN performance, either alone or in a more complex materials system, for a wide range of applications. Additionally, the role that MMN research can play in high-priority research and development (R&D) areas such as the U.S. Materials Genome Initiative, the National Nanotechnology Initiative, the Advanced Manufacturing Initiative, and other similar initiatives that exist internationally was assessed. The workshop also addressed critical issues related to materials research instrumentation and the cyberinfrastructure for materials science research and education, as well as science, technology, engineering, and mathematics (STEM) workforce development, with emphasis on the United States but with an appreciation that similar challenges and opportunities for the materials community exist internationally.

On the origin of the water vapor continuum absorption within rotational and fundamental vibrational bands

NASA Astrophysics Data System (ADS)

Serov, E. A.; Odintsova, T. A.; Tretyakov, M. Yu.; Semenov, V. E.

2017-05-01

Analysis of the continuum absorption in water vapor at room temperature within the purely rotational and fundamental ro-vibrational bands shows that a significant part (up to a half) of the observed absorption cannot be explained within the framework of the existing concepts of the continuum. Neither of the two most prominent mechanisms of continuum originating, namely, the far wings of monomer lines and the dimers, cannot reproduce the currently available experimental data adequately. We propose a new approach to developing a physically based model of the continuum. It is demonstrated that water dimers and wings of monomer lines may contribute equally to the continuum within the bands, and their contribution should be taken into account in the continuum model. We propose a physical mechanism giving missing justification for the super-Lorentzian behavior of the intermediate line wing. The qualitative validation of the proposed approach is given on the basis of a simple empirical model. The obtained results are directly indicative of the necessity to reconsider the existing line wing theory and can guide this consideration.

Thinking about Fantasy: Are Children Fundamentally Different Thinkers and Believers from Adults?

ERIC Educational Resources Information Center

Woolley, Jacqueline D.

1997-01-01

Reviews research on children's and adults' beliefs about fantasy and their tendency to engage in "magical thinking." Suggests that children are not fundamentally different from adults in their ability to distinguish fantasy from reality. Both entertain fantastical beliefs and engage in magical thinking. Offers suggestions regarding age…

Cross-Linguistic Differences in Bilinguals' Fundamental Frequency Ranges

ERIC Educational Resources Information Center

Ordin, Mikhail; Mennen, Ineke

2017-01-01

Purpose: We investigated cross-linguistic differences in fundamental frequency range (FFR) in Welsh-English bilingual speech. This is the first study that reports gender-specific behavior in switching FFRs across languages in bilingual speech. Method: FFR was conceptualized as a behavioral pattern using measures of span (range of fundamental…

Cooling of hot bubbles by surface texture during the boiling crisis

NASA Astrophysics Data System (ADS)

Dhillon, Navdeep; Buongiorno, Jacopo; Varanasi, Kripa

2015-11-01

We report the existence of maxima in critical heat flux (CHF) enhancement for pool boiling on textured hydrophilic surfaces and reveal the interaction mechanism between bubbles and surface texture that governs the boiling crisis phenomenon. Boiling is a process of fundamental importance in many engineering and industrial applications but the maximum heat flux that can be absorbed by the boiling liquid (or CHF) is limited by the boiling crisis. Enhancing the CHF of industrial boilers by surface texturing can lead to substantial energy savings and reduction in greenhouse gas emissions on a global scale. However, the fundamental mechanisms behind this enhancement are not well understood, with some previous studies indicating that CHF should increase monotonically with increasing texture density. However, using pool boiling experiments on a parametrically designed set of plain and nano-textured micropillar surfaces, we show that there is an optimum intermediate texture density that maximizes CHF and further that the length scale of this texture is of fundamental significance. Using imbibition experiments and high-speed optical and infrared imaging, we reveal the fundamental mechanisms governing the CHF enhancement maxima in boiling crisis. We acknowledge funding from the Chevron corporation.

Antimatter Past, Present and Future

NASA Astrophysics Data System (ADS)

Zichichi, Antonino

2001-11-01

In order to have matter we need fundamental fermions (quarks and leptons), particles (mesons and baryons) and nuclei. For antimatter to exist, the antifundamental fermions, as well as the antiparticles and the antinuclei, are needed. The masses associated with these components of matter are the "intrinsic" (quarks and leptons), the "confinement" (mesons and baryons) and the "binding" [either nuclear (nuclei), or electromagnetic (atoms)]. The first two are positive, the two "binding" ones are negative. These masses have different origins. No one has been able to establish the origin of the "intrinsic" masses (it could be the Higgs mechanism, but this lacks experimental confirmation so far). The "confinement" masses are QCD non-perturbative effects. The nuclear "binding" masses are QCD-induced colour neutral effects; the electromagnetic "binding" is due to QED and, since QED is the best experimentally checked RQFT, its validity in terms of the CPT symmetry cannot easily be questioned and this is why the electromagnetic "binding" is not included in this review. If CPT were theoretically well established as it was when discovered, all mass differences, between any matter and its antimatter partner, should be zero. The best limits for the validity of CPT invariance in the field of masses are two: i) the determination of a very small upper limit on Δ {m}{{Kbar K}} (the mass difference between a meson and an antimeson) derived from the mass difference between the long- and the short-lived K-mesons, ΔmKLKS ii) the measurements of the charge over mass ratio ({{Q} / {M}}) for protons and antiprotons. These experimental results are discussed in terms of their relevance to check CPT invariance for the "intrinsic" and for the "confinement" masses. It is pointed out that the value of Δ {m}{{Kbar K}} could be totally insensitive to a large CPT breaking in the intrinsic quark masses. Furthermore, the physics of "intrinsic" and "confinement" masses has nothing to do with the nuclear "binding" masses, where the limits are very poor. A deuteron-antideuteron mass difference Δ {m}{{Dbar D}} , many orders of magnitude larger than the present limits in the "confinement" and in the "intrinsic" masses, could exist and have no effects on the CPT limits known so far, including the very high precision measurements on Δ {m}{{Kbar K}} and on ({{Q} / {M}}). New experiments need to be performed in nuclear matter-antimatter in order to establish the validity of CPT invariance in non-perturbative - colour neutral - QCD effects, such as the nuclear binding forces which no one is able to describe in terms of a fundamental RQFT.

Biostatistics Series Module 5: Determining Sample Size

PubMed Central

Hazra, Avijit; Gogtay, Nithya

2016-01-01

Determining the appropriate sample size for a study, whatever be its type, is a fundamental aspect of biomedical research. An adequate sample ensures that the study will yield reliable information, regardless of whether the data ultimately suggests a clinically important difference between the interventions or elements being studied. The probability of Type 1 and Type 2 errors, the expected variance in the sample and the effect size are the essential determinants of sample size in interventional studies. Any method for deriving a conclusion from experimental data carries with it some risk of drawing a false conclusion. Two types of false conclusion may occur, called Type 1 and Type 2 errors, whose probabilities are denoted by the symbols σ and β. A Type 1 error occurs when one concludes that a difference exists between the groups being compared when, in reality, it does not. This is akin to a false positive result. A Type 2 error occurs when one concludes that difference does not exist when, in reality, a difference does exist, and it is equal to or larger than the effect size defined by the alternative to the null hypothesis. This may be viewed as a false negative result. When considering the risk of Type 2 error, it is more intuitive to think in terms of power of the study or (1 − β). Power denotes the probability of detecting a difference when a difference does exist between the groups being compared. Smaller α or larger power will increase sample size. Conventional acceptable values for power and α are 80% or above and 5% or below, respectively, when calculating sample size. Increasing variance in the sample tends to increase the sample size required to achieve a given power level. The effect size is the smallest clinically important difference that is sought to be detected and, rather than statistical convention, is a matter of past experience and clinical judgment. Larger samples are required if smaller differences are to be detected. Although the principles are long known, historically, sample size determination has been difficult, because of relatively complex mathematical considerations and numerous different formulas. However, of late, there has been remarkable improvement in the availability, capability, and user-friendliness of power and sample size determination software. Many can execute routines for determination of sample size and power for a wide variety of research designs and statistical tests. With the drudgery of mathematical calculation gone, researchers must now concentrate on determining appropriate sample size and achieving these targets, so that study conclusions can be accepted as meaningful. PMID:27688437

Research on the fundamental principles of China's marine invasive species prevention legislation.

PubMed

Bai, Jiayu

2014-12-15

China's coastal area is severely damaged by marine invasive species. Traditional tort theory resolves issues relevant to property damage or personal injuries, through which plaintiffs cannot cope with the ecological damage caused by marine invasive species. Several defects exist within the current legal regimes, such as imperfect management systems, insufficient unified technical standards, and unsound legal responsibility systems. It is necessary to pass legislation to prevent the ecological damage caused by marine invasive species. This investigation probes the fundamental principles needed for the administration and legislation of an improved legal framework to combat the problem of invasive species within China's coastal waters. Copyright © 2014 Elsevier Ltd. All rights reserved.

The Myth of Gender Neutrality

NASA Astrophysics Data System (ADS)

Dancy, Melissa

2004-09-01

It is well known that women are underrepresented in physics. The prevailing view is that there is a "leaky pipeline" of female physicists which has lead to a focus on providing mentors and increasing the opportunity for girls to experience science. The assumption is that the numbers of women in physics can be increased by integrating women into the existing structure. Although it may seem reasonable, women are making only small gains in participation levels. In this paper, I explore the idea that there is no leaky pipeline. Rather, the environment is fundamentally "male" and women will never be equally represented until fundamental changes are made in both our educational system and in the cultural assumptions of our physics community.

Report of the Dark Energy Task Force

DOE R&D Accomplishments Database

Albrecht, Andreas; Bernstein, Gary; Cahn, Robert; Freedman, Wendy L.; Hewitt, Jacqueline; Hu, Wayne; Huth, John; Kamionkowski, Marc; Kolb, Edward W.; Knox, Lloyd; Mather, John C.

2006-01-01

Dark energy appears to be the dominant component of the physical Universe, yet there is no persuasive theoretical explanation for its existence or magnitude. The acceleration of the Universe is, along with dark matter, the observed phenomenon that most directly demonstrates that our theories of fundamental particles and gravity are either incorrect or incomplete. Most experts believe that nothing short of a revolution in our understanding of fundamental physics will be required to achieve a full understanding of the cosmic acceleration. For these reasons, the nature of dark energy ranks among the very most compelling of all outstanding problems in physical science. These circumstances demand an ambitious observational program to determine the dark energy properties as well as possible.

Scaling Laws in Arctic Permafrost River Basins: Statistical Signature in Transition

NASA Astrophysics Data System (ADS)

Rowland, J. C.; Gangodagamage, C.; Wilson, C. J.; Prancevic, J. P.; Brumby, S. P.; Marsh, P.; Crosby, B. T.

2011-12-01

The Arctic landscape has been shown to be fundamentally different from the temperate landscape in many ways. Long winters and cold temperatures have led to the development of permafrost, perennially frozen ground, that controls geomorphic processes and the structure of the Arctic landscape. Climate warming is causing changes in permafrost and the active layer (the seasonally thawed surface layer) that is driving an increase in thermal erosion including thermokarst (collapsed soil), retrogressive thaw slumps, and gullies. These geomorphic anomalies in the arctic landscapes have not been well quantified, even though some of the landscape geomorphic and hydrologic characteristics and changes are detectable by our existing sensor networks. We currently lack understanding of the fundamental fluvio-thermal-erosional processes that underpin Arctic landscape structure and form, which limits our ability to develop models to predict the landscape response to current and future climate change. In this work, we seek a unified framework that can explain why permafrost landscapes are different from temperate landscapes. We use high resolution LIDAR data to analyze arctic geomorphic processes at a scale of less than a 1 m and demonstrate our ability to quantify the fundamental difference in the arctic landscape. We first simulate the arctic hillslopes from a stochastic space-filling network and demonstrate that the flow-path convergent properties of arctic landscape can be effectively captured from this simple model, where the simple model represents a landscape flowpath arrangement on a relatively impervious frozen soil layer. Further, we use a novel data processing algorithm to analyze landscape attributes such as slope, curvature, flow-accumulation, elevation-drops and other geomorphic properties, and show that the pattern of diffusion and advection dominated soil transport processes (diffusion/advection regime transition) in the arctic landscape is substantially different from the pattern in temperate landscapes. Our results suggest that Arctic landscapes are characterized by relatively undissected, long planar hillslopes, which convey sediment to quasi-fluvial valleys through long (~ 1 km) flow-paths. Further, we also document that broad planar hillslopes abruptly converge, forcing rapid subsurface flow accumulation at channel heads. This topographic characteristic can successfully be used to explain the position of erosion features. Finally we estimate the landscape model parameters for the arctic landscape that can be successfully used to model development and validation purposes.

The wavefield of acoustic logging in a cased hole with a single casing—Part II: a dipole tool

NASA Astrophysics Data System (ADS)

Wang, Hua; Fehler, Michael

2018-02-01

The acoustic method, being the most effective method for cement bond evaluation, has been used by industry for more than a half century. However, the methods currently used are almost always focused on the first arrival (especially for sonic logging), which has limitations. We use a 3-D finite-difference method to numerically simulate the wavefields from a dipole source in a single-cased hole with different cement conditions. By using wavefield snapshots and dispersion curves, we interpret the characteristics of the modes in the models. We investigate the effect of source frequency, the thickness and location of fluid columns on different modes. The dipole wavefield in a single-cased hole consists of a leaky P (for frequency >10 kHz) from formation, formation flexural, and also some casing modes. Depending on the mode, their behaviour is sometimes sensitive to the existence of fluid between the cement and formation and sometimes sensitive to the existence of fluid between the casing and cement. The formation S velocity can be obtained from the formation flexural mode at low frequency. However, interference from high-order casing modes makes the leaky P invisible and P velocity determination difficult when the casing is not well cemented. The dispersion curve of the formation flexural mode is sensitive to the fluid thickness when fluid exists only at the interface between casing and cement. The fundamental casing dipole mode is only sensitive to the total fluid thickness in the annulus between casing and formation. Either the arrival time or amplitude of the high-order casing dipole mode is sensitive to the fluid column when the fluid column is next to the casing. We provide a table that summarizes the ability of different modes to detect fluid columns between various layers of casing, cement and formation. Based on the results, we suggest a data processing flow for field application, which will highly improve cement evaluation.

Fundamental Fermions (e.g. Neutrinos) as Topological Objects

NASA Astrophysics Data System (ADS)

Fitzpatrick, Gerald L.

1999-05-01

A new internal ``macroscopic'' description of fundamental fermions based on a matrix-generalization (F) of the scalar fermion-number f, predicts that only three families of quarks and leptons, and their associated neutrinos (ν_e, ν_μ and ν_τ), exist [1]. Moreover, this description places important phtopological constraints on neutrino mixtures [2]. With respect to F, the topology of the νe (ν_μ or ν_τ) is that of a cylinder (Möbius strip). Assuming that topology-changing neutrino-neutrino transitions are suppressed (e.g., one cannot continuously deform a donut into a sphere), while topology-maintaining transitions are relatively enhanced, one may have an explanation for short-distance observations of (nearly) maximal ν_μ-ν_τ mixing [3]. To test this idea, simple topological arguments were used to deduce a matrix describing long-distance neutrino mixtures, which is phidentical to that proposed by Georgi and Glashow on different grounds [4]. Experimental confirmation of this prediction would support the new description, which requires the νe and (ν_μ or ν_τ) to start ``life'' as topologically-distinct quantum objects.l [1] http://www.amazon.com/exec/obidos/ISBN=0965569500, [2] G. L. Fitzpatrick, aps1999feb12\\underbar001 at http://publish.aps.org/eprint/, [3] hep-ex/981001, [4] hep-ph/9808293, p. 5, Eq. 20.

Health Implications of Increased Coal Use in the Western States

PubMed Central

Guidotti, Tee L.

1979-01-01

The National Energy Plan proposed by President Carter provides for the rapid development of coal resources in the United States, particularly in the West. The potential consequences for health of this development were considered by the Advisory Committee on Health and Environmental Effects of Increased Coal Utilization, reporting to the Department of Energy. Their report recommended rigid adherence to pertinent existing regulations, improved environmental monitoring, expanded research in selected relevant topics and development of procedures for selecting the sites of new coal-fired power plants. Although the report was a major exercise in technology assessment, it is fundamentally a cautious document that proposes no new solutions or approaches. A review of occupational and community health problems associated with coal mining and coal utilization suggests that lessons from past experiences, especially in Appalachia, cannot be applied to the West uncritically. The two regions are fundamentally different in scale, topography and social development. In the West, future problems related to coal are likely to derive from unknown risks associated with coal processing technologies, land reclamation and water quality at the sites of power generation, and extensive social and demographic changes at centers of industrial activity that may have secondary effects on health. Additional considerations should supplement the recommendations of the Advisory Committee report. PMID:483803

Health implications of increased coal use in the Western States.

PubMed

Guidotti, T L

1979-07-01

The National Energy Plan proposed by President Carter provides for the rapid development of coal resources in the United States, particularly in the West. The potential consequences for health of this development were considered by the Advisory Committee on Health and Environmental Effects of Increased Coal Utilization, reporting to the Department of Energy. Their report recommended rigid adherence to pertinent existing regulations, improved environmental monitoring, expanded research in selected relevant topics and development of procedures for selecting the sites of new coal-fired power plants. Although the report was a major exercise in technology assessment, it is fundamentally a cautious document that proposes no new solutions or approaches. A review of occupational and community health problems associated with coal mining and coal utilization suggests that lessons from past experiences, especially in Appalachia, cannot be applied to the West uncritically. The two regions are fundamentally different in scale, topography and social development. In the West, future problems related to coal are likely to derive from unknown risks associated with coal processing technologies, land reclamation and water quality at the sites of power generation, and extensive social and demographic changes at centers of industrial activity that may have secondary effects on health. Additional considerations should supplement the recommendations of the Advisory Committee report.

Optical dosimetry of radiotherapy beams using Cherenkov radiation: the relationship between light emission and dose.

PubMed

Glaser, Adam K; Zhang, Rongxiao; Gladstone, David J; Pogue, Brian W

2014-07-21

Recent studies have proposed that light emitted by the Cherenkov effect may be used for a number of radiation therapy dosimetry applications. There is a correlation between the captured light and expected dose under certain conditions, yet discrepancies have also been observed and a complete examination of the theoretical differences has not been done. In this study, a fundamental comparison between the Cherenkov emission and absorbed dose was explored for x-ray photons, electrons, and protons using both a theoretical and Monte Carlo-based analysis. Based on the findings of where dose correlates with Cherenkov emission, it was concluded that for x-ray photons the light emission would be optimally suited for narrow beam stereotactic radiation therapy and surgery validation studies, for verification of dynamic intensity-modulated and volumetric modulated arc therapy treatment plans in water tanks, near monoenergetic sources (e.g., Co-60 and brachy therapy sources) and also for entrance and exit surface imaging dosimetry of both narrow and broad beams. For electron use, Cherenkov emission was found to be only suitable for surface dosimetry applications. Finally, for proton dosimetry, there exists a fundamental lack of Cherenkov emission at the Bragg peak, making the technique of little use, although post-irradiation detection of light emission from radioisotopes could prove to be useful.

Designing ECM-mimetic Materials Using Protein Engineering

PubMed Central

Cai, Lei; Heilshorn, Sarah C.

2014-01-01

The natural extracellular matrix (ECM), with its multitude of evolved cell-instructive and cell-responsive properties, provides inspiration and guidelines for the design of engineered biomaterials. One strategy to create ECM-mimetic materials is the modular design of protein-based engineered ECM (eECM) scaffolds. This modular design strategy involves combining multiple protein domains with different functionalities into a single, modular polymer sequence, resulting in a multifunctional matrix with independent tunability of the individual domain functions. These eECMs often enable decoupled control over multiple material properties for fundamental studies of cell-matrix interactions. In addition, since the eECMs are frequently composed entirely of bioresorbable amino acids, these matrices have immense clinical potential for a variety of regenerative medicine applications. This brief review demonstrates how fundamental knowledge gained from structure-function studies of native proteins can be exploited in the design of novel protein-engineered biomaterials. While the field of protein-engineered biomaterials has existed for over 20 years, the community is only now beginning to fully explore the diversity of functional peptide modules that can be incorporated into these materials. We have chosen to highlight recent examples that either (1) demonstrate exemplary use as matrices with cell-instructive and cell-responsive properties or (2) demonstrate outstanding creativity in terms of novel molecular-level design and macro-level functionality. PMID:24365704

Methodological advances in predicting flow-induced dynamics of plants using mechanical-engineering theory.

PubMed

de Langre, Emmanuel

2012-03-15

The modeling of fluid-structure interactions, such as flow-induced vibrations, is a well-developed field of mechanical engineering. Many methods exist, and it seems natural to apply them to model the behavior of plants, and potentially other cantilever-like biological structures, under flow. Overcoming this disciplinary divide, and the application of such models to biological systems, will significantly advance our understanding of ecological patterns and processes and improve our predictive capabilities. Nonetheless, several methodological issues must first be addressed, which I describe here using two practical examples that have strong similarities: one from agricultural sciences and the other from nuclear engineering. Very similar issues arise in both: individual and collective behavior, small and large space and time scales, porous modeling, standard and extreme events, trade-off between the surface of exchange and individual or collective risk of damage, variability, hostile environments and, in some aspects, evolution. The conclusion is that, although similar issues do exist, which need to be exploited in some detail, there is a significant gap that requires new developments. It is obvious that living plants grow in and adapt to their environment, which certainly makes plant biomechanics fundamentally distinct from classical mechanical engineering. Moreover, the selection processes in biology and in human engineering are truly different, making the issue of safety different as well. A thorough understanding of these similarities and differences is needed to work efficiently in the application of a mechanistic approach to ecology.

Genetic and phenotypic divergence in an island bird: isolation by distance, by colonization or by adaptation?

PubMed

Spurgin, Lewis G; Illera, Juan Carlos; Jorgensen, Tove H; Dawson, Deborah A; Richardson, David S

2014-03-01

Discerning the relative roles of adaptive and nonadaptive processes in generating differences among populations and species, as well as how these processes interact, is a fundamental aim in biology. Both genetic and phenotypic divergence across populations can be the product of limited dispersal and gradual genetic drift across populations (isolation by distance), of colonization history and founder effects (isolation by colonization) or of adaptation to different environments preventing migration between populations (isolation by adaptation). Here, we attempt to differentiate between these processes using island populations of Berthelot's pipit (Anthus berthelotii), a passerine bird endemic to three Atlantic archipelagos. Using microsatellite markers and approximate Bayesian computation, we reveal that the northward colonization of this species ca. 8500 years ago resulted in genetic bottlenecks in the colonized archipelagos. We then show that high levels of genetic structure exist across archipelagos and that these are consistent with a pattern of isolation by colonization, but not with isolation by distance or adaptation. Finally, we show that substantial morphological divergence also exists and that this is strongly concordant with patterns of genetic structure and bottleneck history, but not with environmental differences or geographic distance. Overall, our data suggest that founder effects are responsible for both genetic and phenotypic changes across archipelagos. Our findings provide a rare example of how founder effects can persist over evolutionary timescales and suggest that they may play an important role in the early stages of speciation. © 2014 John Wiley & Sons Ltd.

Vulnerability and adaptation to climate-related fire impacts in rural and urban interior Alaska

USGS Publications Warehouse

Trainor, Sarah F.; Calef, Monika; Natcher, David; Chapin, F. Stuart; McGuire, A. David; Huntington, Orville; Duffy, Paul A.; Rupp, T. Scott; DeWilde, La'Ona; Kwart, Mary; Fresco, Nancy; Lovecraft, Amy Lauren

2009-01-01

This paper explores whether fundamental differences exist between urban and rural vulnerability to climate-induced changes in the fire regime of interior Alaska. We further examine how communities and fire managers have responded to these changes and what additional adaptations could be put in place. We engage a variety of social science methods, including demographic analysis, semi-structured interviews, surveys, workshops and observations of public meetings. This work is part of an interdisciplinary study of feedback and interactions between climate, vegetation, fire and human components of the Boreal forest social–ecological system of interior Alaska. We have learned that although urban and rural communities in interior Alaska face similar increased exposure to wildfire as a result of climate change, important differences exist in their sensitivity to these biophysical, climate-induced changes. In particular, reliance on wild foods, delayed suppression response, financial resources and institutional connections vary between urban and rural communities. These differences depend largely on social, economic and institutional factors, and are not necessarily related to biophysical climate impacts per se. Fire management and suppression action motivated by political, economic or other pressures can serve as unintentional or indirect adaptation to climate change. However, this indirect response alone may not sufficiently reduce vulnerability to a changing fire regime. More deliberate and strategic responses may be required, given the magnitude of the expected climate change and the likelihood of an intensification of the fire regime in interior Alaska.

[Is there an essence of caring? A core of Nursing? Criticism of Katie Erikssons' "Vårdandets ide"].

PubMed

Nielsen, G; Larsen, B

1989-01-01

In her book "Vårdandets Ide" the Finnish nurse, Katie Eriksson puts forward the thesis, that all kind af caring activities do have a common core. To establish this thesis professor Eriksson introduces the Aristotelian notion of an essence: Different kinds of caring activities do have a common set of essential properties constituting the act of caring. In this article we submit a thesis to the contrary: There may exist no set of essential properties common to all kind of caring activities: The belief is induced in us, that there may exist some common core to all caring activities, because the same term, namely "caring", is being used as a general term to cover a wide field of very different kinds of activities. Instead of the traditional Aristotelian craving for generality issuing in the notion of an essence, we suggest the use of the more modern Wittgensteinian concept of a family resemblance: There may be no common core but a set of family resemblances among the different kinds of caring activities. Instead of an abstract philosophical search for the common core of caring activities, we propose nurses to look at the actual use of the term "to care", thereby circumscribing the subject matter of caring. It goes without saying, that this article contains a good deal of philosophical arguments including, of course, an introduction to some basic Aristotelian notions, fundamental distinctions in the theory of definition, and finally the Wittgensteinian concept of family resemblance.

Violent relationships at the social-ecological level: A multi-mediation model to predict adolescent victimization by peers, bullying and depression in early and late adolescence.

PubMed

Oriol, Xavier; Miranda, Rafael; Amutio, Alberto; Acosta, Hedy C; Mendoza, Michelle C; Torres-Vallejos, Javier

2017-01-01

From the social-ecological perspective, exposure to violence at the different developmental levels is fundamental to explain the dynamics of violence and victimization in educational centers. The following study aims at analyzing how these relationships are produced in the Peruvian context, where structural violence situations exist. A multi-mediation structural model with 21,416 Peruvian adolescents (M = 13.69; SD = 0.71) was conducted to determine the influence of violence in the school environment on violence perceived within school and violence exercised by teachers. In addition, it was also intended to determine whether these violent relationships predict depression through loneliness, and bullying through peer victimization. The existence of differences between early and late adolescence was also verified. Results confirm that violence in the school setting has high influence on violence exercised by adolescents and teachers within the school. Teacher violence is the most important predictor of depression through loneliness, and encourages peer victimization and the emergence of aggressive behavior. Exposure to violence exercised by support sources-teachers and classmates-explains more than 90% of the total variance explained in bullying behavior. Differences were found between early and late adolescence models. The high prevalence of structural violence in school settings facilitates the bullying/victimization dynamics within school. From a social-ecological perspective, this result suggests the importance of network cooperation at a mesosystem level, with teachers from educational centers playing a crucial role in the prevention of bullying/victimization.

Predicting Achievable Fundamental Frequency Ranges in Vocalization Across Species

PubMed Central

Titze, Ingo; Riede, Tobias; Mau, Ted

2016-01-01

Vocal folds are used as sound sources in various species, but it is unknown how vocal fold morphologies are optimized for different acoustic objectives. Here we identify two main variables affecting range of vocal fold vibration frequency, namely vocal fold elongation and tissue fiber stress. A simple vibrating string model is used to predict fundamental frequency ranges across species of different vocal fold sizes. While average fundamental frequency is predominantly determined by vocal fold length (larynx size), range of fundamental frequency is facilitated by (1) laryngeal muscles that control elongation and by (2) nonlinearity in tissue fiber tension. One adaptation that would increase fundamental frequency range is greater freedom in joint rotation or gliding of two cartilages (thyroid and cricoid), so that vocal fold length change is maximized. Alternatively, tissue layers can develop to bear a disproportionate fiber tension (i.e., a ligament with high density collagen fibers), increasing the fundamental frequency range and thereby vocal versatility. The range of fundamental frequency across species is thus not simply one-dimensional, but can be conceptualized as the dependent variable in a multi-dimensional morphospace. In humans, this could allow for variations that could be clinically important for voice therapy and vocal fold repair. Alternative solutions could also have importance in vocal training for singing and other highly-skilled vocalizations. PMID:27309543

Aerospace applications of sodium batteries using novel cathode materials

NASA Technical Reports Server (NTRS)

Ratnakumar, B. V.; Di Stefano, S.; Bankston, C. P.

1989-01-01

Preliminary fundamental investigations aimed at evaluating sodium metal chloride systems for future aerospace applications are described. Since the sodium metal chloride systems are relatively new, the approach has been to characterize their fundamental properties in order to understand their limitations. To this end, a series of fundamental electrochemical investigations have been carried out, the results of which are reported here. The metal chloride cathodes show high exchange current densities which corroborate their good reversibility in a battery application. The reduction mechanisms appear to be complex and involve multielectron transfer steps and intermediates. Such intermediates in the reaction mechanism have already been identified in the case of FeCl2. Similar mechanisms may be operative in the case of NiCl2. CuCl2, however, exhibits a second relaxation loop in the impedance plot at low frequencies and also a sloping discharge curve, unlike FeCl2 and NiCl2, which may indicate the existence of monovalent copper in the reduction mechanism.

The foundations of object permanence: does perceived cohesion determine infants' appreciation of the continuous existence of material objects?

PubMed

Cacchione, Trix

2013-09-01

One of the most fundamental achievements in infants' cognitive development is their appreciation that material objects exist permanently in space and time. Recent findings suggest that infants fail to identify fragmented material objects as continuously existing items. Four experiments assessed 8-12-month-old infants' ability to further represent an object that was fragmented into two or more parts. Results suggest that infants successfully trace the spatiotemporal displacement of fragmented objects, but that their processing of size/quantity-related property information may be affected. This suggests that, contrary to recent claims, 8- to 12-month-old infants can and do appreciate the continuity of fragmented objects. Copyright © 2013 Elsevier B.V. All rights reserved.

Students' Perceptions of Dynamics Concept Pairs and Correlation with Their Problem-Solving Performance

ERIC Educational Resources Information Center

Fang, Ning

2012-01-01

A concept pair is a pair of concepts that are fundamentally different but closely related. To develop a solid conceptual understanding in dynamics (a foundational engineering science course) and physics, students must understand the fundamental difference and relationship between two concepts that are included in each concept pair. However, all…

Time-varying economic dominance in financial markets: A bistable dynamics approach

NASA Astrophysics Data System (ADS)

He, Xue-Zhong; Li, Kai; Wang, Chuncheng

2018-05-01

By developing a continuous-time heterogeneous agent financial market model of multi-assets traded by fundamental and momentum investors, we provide a potential mechanism for generating time-varying dominance between fundamental and non-fundamental in financial markets. We show that investment constraints lead to the coexistence of a locally stable fundamental steady state and a locally stable limit cycle around the fundamental, characterized by a Bautin bifurcation. This provides a mechanism for market prices to switch stochastically between the two persistent but very different market states, leading to the coexistence and time-varying dominance of seemingly controversial efficient market and price momentum over different time periods. The model also generates other financial market stylized facts, such as spillover effects in both momentum and volatility, market booms, crashes, and correlation reduction due to cross-sectional momentum trading. Empirical evidence based on the U.S. market supports the main findings. The mechanism developed in this paper can be used to characterize time-varying economic dominance in economics and finance in general.

Time-varying economic dominance in financial markets: A bistable dynamics approach.

PubMed

He, Xue-Zhong; Li, Kai; Wang, Chuncheng

2018-05-01

By developing a continuous-time heterogeneous agent financial market model of multi-assets traded by fundamental and momentum investors, we provide a potential mechanism for generating time-varying dominance between fundamental and non-fundamental in financial markets. We show that investment constraints lead to the coexistence of a locally stable fundamental steady state and a locally stable limit cycle around the fundamental, characterized by a Bautin bifurcation. This provides a mechanism for market prices to switch stochastically between the two persistent but very different market states, leading to the coexistence and time-varying dominance of seemingly controversial efficient market and price momentum over different time periods. The model also generates other financial market stylized facts, such as spillover effects in both momentum and volatility, market booms, crashes, and correlation reduction due to cross-sectional momentum trading. Empirical evidence based on the U.S. market supports the main findings. The mechanism developed in this paper can be used to characterize time-varying economic dominance in economics and finance in general.

Furan Fragmentation in the Gas Phase: New Insights from Statistical and Molecular Dynamics Calculations

DOE Office of Scientific and Technical Information (OSTI.GOV)

Erdmann, Ewa; Labuda, Marta; Aguirre, Nestor F.

We present a complete exploration of the different fragmentation mechanisms of furan (C 4H 4O) operating at low and high energies. Three different theoretical approaches are combined to determine the structure of all possible reaction intermediates, many of them not described in previous studies, and a large number of pathways involving three types of fundamental elementary mechanisms: isomerization, fragmentation, and H/H 2 loss processes (this last one was not yet explored). Our results are compared with the existing experimental and theoretical investigations for furan fragmentation. At low energies the first processes to appear are isomerization, which always implies the breakingmore » of one C–O bond and one or several hydrogen transfers; at intermediate energies the fragmentation of the molecular skeleton becomes the most relevant mechanism; and H/H 2 loss is the dominant processes at high energy. However, the three mechanisms are active in very wide energy ranges and, therefore, at most energies there is a competition among them.« less

Furan Fragmentation in the Gas Phase: New Insights from Statistical and Molecular Dynamics Calculations

DOE PAGES

Erdmann, Ewa; Labuda, Marta; Aguirre, Nestor F.; ...

2018-03-15

We present a complete exploration of the different fragmentation mechanisms of furan (C 4H 4O) operating at low and high energies. Three different theoretical approaches are combined to determine the structure of all possible reaction intermediates, many of them not described in previous studies, and a large number of pathways involving three types of fundamental elementary mechanisms: isomerization, fragmentation, and H/H 2 loss processes (this last one was not yet explored). Our results are compared with the existing experimental and theoretical investigations for furan fragmentation. At low energies the first processes to appear are isomerization, which always implies the breakingmore » of one C–O bond and one or several hydrogen transfers; at intermediate energies the fragmentation of the molecular skeleton becomes the most relevant mechanism; and H/H 2 loss is the dominant processes at high energy. However, the three mechanisms are active in very wide energy ranges and, therefore, at most energies there is a competition among them.« less

The scaling features of the 3D organization of chromosomes are highlighted by a transformation à la Kadanoff of Hi-C data

NASA Astrophysics Data System (ADS)

Chiariello, Andrea M.; Bianco, Simona; Annunziatella, Carlo; Esposito, Andrea; Nicodemi, Mario

2017-11-01

Technologies such as Hi-C and GAM have revealed that chromosomes are not randomly folded into the nucleus of cells, but are composed by a sequence of contact domains (TADs), each typically 0.5 Mb long. However, the larger scale organization of the genome remains still not well understood. To investigate the scaling behaviour of chromosome folding, here we apply an approach à la Kadanoff, inspired by the Renormalization Group theory, to Hi-C interaction data, across different cell types and chromosomes. We find that the genome is characterized by complex scaling features, where the average size of contact domains exhibits a power-law behaviour with the rescaling level. That is compatible with the existence of contact domains extending across length scales up to chromosomal sizes. The scaling exponent is statistically indistinguishable among the different murine cell types analysed. These results point toward a scenario of a universal higher-order spatial architecture of the genome, which could reflect fundamental, organizational principles.

Origami building blocks: Generic and special four-vertices

NASA Astrophysics Data System (ADS)

Waitukaitis, Scott; van Hecke, Martin

2016-02-01

Four rigid panels connected by hinges that meet at a point form a four-vertex, the fundamental building block of origami metamaterials. Most materials designed so far are based on the same four-vertex geometry, and little is known regarding how different geometries affect folding behavior. Here we systematically categorize and analyze the geometries and resulting folding motions of Euclidean four-vertices. Comparing the relative sizes of sector angles, we identify three types of generic vertices and two accompanying subtypes. We determine which folds can fully close and the possible mountain-valley assignments. Next, we consider what occurs when sector angles or sums thereof are set equal, which results in 16 special vertex types. One of these, flat-foldable vertices, has been studied extensively, but we show that a wide variety of qualitatively different folding motions exist for the other 15 special and 3 generic types. Our work establishes a straightforward set of rules for understanding the folding motion of both generic and special four-vertices and serves as a roadmap for designing origami metamaterials.

Origami building blocks: Generic and special four-vertices.

PubMed

Waitukaitis, Scott; van Hecke, Martin

2016-02-01

Four rigid panels connected by hinges that meet at a point form a four-vertex, the fundamental building block of origami metamaterials. Most materials designed so far are based on the same four-vertex geometry, and little is known regarding how different geometries affect folding behavior. Here we systematically categorize and analyze the geometries and resulting folding motions of Euclidean four-vertices. Comparing the relative sizes of sector angles, we identify three types of generic vertices and two accompanying subtypes. We determine which folds can fully close and the possible mountain-valley assignments. Next, we consider what occurs when sector angles or sums thereof are set equal, which results in 16 special vertex types. One of these, flat-foldable vertices, has been studied extensively, but we show that a wide variety of qualitatively different folding motions exist for the other 15 special and 3 generic types. Our work establishes a straightforward set of rules for understanding the folding motion of both generic and special four-vertices and serves as a roadmap for designing origami metamaterials.

Human adipose-derived stem cells: definition, isolation, tissue-engineering applications.

PubMed

Nae, S; Bordeianu, I; Stăncioiu, A T; Antohi, N

2013-01-01

Recent researches have demonstrated that the most effective repair system of the body is represented by stem cells - unspecialized cells, capable of self-renewal through successive mitoses, which have also the ability to transform into different cell types through differentiation. The discovery of adult stem cells represented an important step in regenerative medicine because they no longer raises ethical or legal issues and are more accessible. Only in 2002, stem cells isolated from adipose tissue were described as multipotent stem cells. Adipose tissue stem cells benefits in tissue engineering and regenerative medicine are numerous. Development of adipose tissue engineering techniques offers a great potential in surpassing the existing limits faced by the classical approaches used in plastic and reconstructive surgery. Adipose tissue engineering clinical applications are wide and varied, including reconstructive, corrective and cosmetic procedures. Nowadays, adipose tissue engineering is a fast developing field, both in terms of fundamental researches and medical applications, addressing issues related to current clinical pathology or trauma management of soft tissue injuries in different body locations.

Temperature structure and emergent flux of the Jovian planets

NASA Technical Reports Server (NTRS)

Silvaggio, P.; Sagan, C.

1978-01-01

Long path, low temperature, moderate resolution spectra of methane and ammonia, broadened by hydrogen and helium, are used to calculate non-gray model atmospheres for the four Jovian planets. The fundamental and first overtone of hydrogen contributes enough absorption to create a thermal inversion for each of the planets. The suite of emergent spectral fluxes and representative limb darkenings and brightenings are calculated for comparison with the Voyager infrared spectra. The temperature differences between Jovian belts and zones corresponds to a difference in the ammonia cirrus particle radii (1 to 3 micron in zones; 10 micron in belts). The Jovian tropopause is approximately at the 0.1 bar level. A thin ammonia cirrus haze should be distributed throughout the Saturnian troposphere; and NH3 gas must be slightly supersaturated or ammonia ice particles are carried upwards convectively in the upper troposphere of Saturn. Substantial methane clouds exist on both Uranus and Neptune. There is some evidence for almost isothermal structures in the deep atmospheres of these two planets.

Mimetic finite difference method

NASA Astrophysics Data System (ADS)

Lipnikov, Konstantin; Manzini, Gianmarco; Shashkov, Mikhail

2014-01-01

The mimetic finite difference (MFD) method mimics fundamental properties of mathematical and physical systems including conservation laws, symmetry and positivity of solutions, duality and self-adjointness of differential operators, and exact mathematical identities of the vector and tensor calculus. This article is the first comprehensive review of the 50-year long history of the mimetic methodology and describes in a systematic way the major mimetic ideas and their relevance to academic and real-life problems. The supporting applications include diffusion, electromagnetics, fluid flow, and Lagrangian hydrodynamics problems. The article provides enough details to build various discrete operators on unstructured polygonal and polyhedral meshes and summarizes the major convergence results for the mimetic approximations. Most of these theoretical results, which are presented here as lemmas, propositions and theorems, are either original or an extension of existing results to a more general formulation using polyhedral meshes. Finally, flexibility and extensibility of the mimetic methodology are shown by deriving higher-order approximations, enforcing discrete maximum principles for diffusion problems, and ensuring the numerical stability for saddle-point systems.

CMOS gate array characterization procedures

NASA Astrophysics Data System (ADS)

Spratt, James P.

1993-09-01

Present procedures are inadequate for characterizing the radiation hardness of gate array product lines prior to personalization because the selection of circuits to be used, from among all those available in the manufacturer's circuit library, is usually uncontrolled. (Some circuits are fundamentally more radiation resistant than others.) In such cases, differences in hardness can result between different designs of the same logic function. Hardness also varies because many gate arrays feature large custom-designed megacells (e.g., microprocessors and random access memories-MicroP's and RAM's). As a result, different product lines cannot be compared equally. A characterization strategy is needed, along with standardized test vehicle(s), methodology, and conditions, so that users can make informed judgments on which gate arrays are best suited for their needs. The program described developed preferred procedures for the radiation characterization of gate arrays, including a gate array evaluation test vehicle, featuring a canary circuit, designed to define the speed versus hardness envelope of the gate array. A multiplier was chosen for this role, and a baseline multiplier architecture is suggested that could be incorporated into an existing standard evaluation circuit chip.

Thermal Response Analysis of Phospholipid Bilayers Using Ellipsometric Techniques.

PubMed

González-Henríquez, Carmen M; Villegas-Opazo, Vanessa A; Sagredo-Oyarce, Dallits H; Sarabia-Vallejos, Mauricio A; Terraza, Claudio A

2017-08-18

Biomimetic planar artificial membranes have been widely studied due to their multiple applications in several research fields. Their humectation and thermal response are crucial for reaching stability; these characteristics are related to the molecular organization inside the bilayer, which is affected by the aliphatic chain length, saturations, and molecule polarity, among others. Bilayer stability becomes a fundamental factor when technological devices are developed-like biosensors-based on those systems. Thermal studies were performed for different types of phosphatidylcholine (PC) molecules: two pure PC bilayers and four binary PC mixtures. These analyses were carried out through the detection of slight changes in their optical and structural parameters via Ellipsometry and Surface Plasmon Resonance (SPR) techniques. Phospholipid bilayers were prepared by Langmuir-Blodgett technique and deposited over a hydrophilic silicon wafer. Their molecular inclination degree, mobility, and stability of the different phases were detected and analyzed through bilayer thickness changes and their optical phase-amplitude response. Results show that certain binary lipid mixtures-with differences in its aliphatic chain length-present a co-existence of two thermal responses due to non-ideal mixing.

Pathogen prevalence predicts human cross-cultural variability in individualism/collectivism.

PubMed

Fincher, Corey L; Thornhill, Randy; Murray, Damian R; Schaller, Mark

2008-06-07

Pathogenic diseases impose selection pressures on the social behaviour of host populations. In humans (Homo sapiens), many psychological phenomena appear to serve an antipathogen defence function. One broad implication is the existence of cross-cultural differences in human cognition and behaviour contingent upon the relative presence of pathogens in the local ecology. We focus specifically on one fundamental cultural variable: differences in individualistic versus collectivist values. We suggest that specific behavioural manifestations of collectivism (e.g. ethnocentrism, conformity) can inhibit the transmission of pathogens; and so we hypothesize that collectivism (compared with individualism) will more often characterize cultures in regions that have historically had higher prevalence of pathogens. Drawing on epidemiological data and the findings of worldwide cross-national surveys of individualism/collectivism, our results support this hypothesis: the regional prevalence of pathogens has a strong positive correlation with cultural indicators of collectivism and a strong negative correlation with individualism. The correlations remain significant even when controlling for potential confounding variables. These results help to explain the origin of a paradigmatic cross-cultural difference, and reveal previously undocumented consequences of pathogenic diseases on the variable nature of human societies.

Breathing mechanics during exercise with added dead space reflect mechanisms of ventilatory control.

PubMed

Wood, Helen E; Mitchell, Gordon S; Babb, Tony G

2009-09-30

Small increases in external dead space (V(D)) augment the exercise ventilatory response via a neural mechanism known as short-term modulation (STM). We hypothesized that breathing mechanics would differ during exercise, increased V(D) and STM. Men were studied at rest and during cycle exercise (10-50W) without (Control) and with added V(D) (200-600ml). With added V(D), V(T) increased via increased end-inspiratory lung volume (EILV), with no change in end-expiratory lung volume (EELV), indicating recruitment of inspiratory muscles only. With exercise, V(T) increased via both decreased EELV and increased EILV, indicating recruitment of both expiratory and inspiratory muscles. A significant interaction between the effects of exercise and V(D) on mean inspiratory flow indicated that the augmented exercise ventilatory response with added V(D) (i.e. STM) resulted from increased drive to the inspiratory muscles. These results reveal different patterns of respiratory muscle recruitment among experimental conditions. Hence, we conclude that fundamental differences exist in the neural control of ventilatory responses during exercise, increased V(D) and STM.

Amplitude and frequency modulation control of sound production in a mechanical model of the avian syrinx.

PubMed

Elemans, Coen P H; Muller, Mees; Larsen, Ole Naesbye; van Leeuwen, Johan L

2009-04-01

Birdsong has developed into one of the important models for motor control of learned behaviour and shows many parallels with speech acquisition in humans. However, there are several experimental limitations to studying the vocal organ - the syrinx - in vivo. The multidisciplinary approach of combining experimental data and mathematical modelling has greatly improved the understanding of neural control and peripheral motor dynamics of sound generation in birds. Here, we present a simple mechanical model of the syrinx that facilitates detailed study of vibrations and sound production. Our model resembles the 'starling resistor', a collapsible tube model, and consists of a tube with a single membrane in its casing, suspended in an external pressure chamber and driven by various pressure patterns. With this design, we can separately control 'bronchial' pressure and tension in the oscillating membrane and generate a wide variety of 'syllables' with simple sweeps of the control parameters. We show that the membrane exhibits high frequency, self-sustained oscillations in the audio range (>600 Hz fundamental frequency) using laser Doppler vibrometry, and systematically explore the conditions for sound production of the model in its control space. The fundamental frequency of the sound increases with tension in three membranes with different stiffness and mass. The lower-bound fundamental frequency increases with membrane mass. The membrane vibrations are strongly coupled to the resonance properties of the distal tube, most likely because of its reflective properties to sound waves. Our model is a gross simplification of the complex morphology found in birds, and more closely resembles mathematical models of the syrinx. Our results confirm several assumptions underlying existing mathematical models in a complex geometry.

Cyclic density functional theory: A route to the first principles simulation of bending in nanostructures

NASA Astrophysics Data System (ADS)

Banerjee, Amartya S.; Suryanarayana, Phanish

2016-11-01

We formulate and implement Cyclic Density Functional Theory (Cyclic DFT) - a self-consistent first principles simulation method for nanostructures with cyclic symmetries. Using arguments based on Group Representation Theory, we rigorously demonstrate that the Kohn-Sham eigenvalue problem for such systems can be reduced to a fundamental domain (or cyclic unit cell) augmented with cyclic-Bloch boundary conditions. Analogously, the equations of electrostatics appearing in Kohn-Sham theory can be reduced to the fundamental domain augmented with cyclic boundary conditions. By making use of this symmetry cell reduction, we show that the electronic ground-state energy and the Hellmann-Feynman forces on the atoms can be calculated using quantities defined over the fundamental domain. We develop a symmetry-adapted finite-difference discretization scheme to obtain a fully functional numerical realization of the proposed approach. We verify that our formulation and implementation of Cyclic DFT is both accurate and efficient through selected examples. The connection of cyclic symmetries with uniform bending deformations provides an elegant route to the ab-initio study of bending in nanostructures using Cyclic DFT. As a demonstration of this capability, we simulate the uniform bending of a silicene nanoribbon and obtain its energy-curvature relationship from first principles. A self-consistent ab-initio simulation of this nature is unprecedented and well outside the scope of any other systematic first principles method in existence. Our simulations reveal that the bending stiffness of the silicene nanoribbon is intermediate between that of graphene and molybdenum disulphide - a trend which can be ascribed to the variation in effective thickness of these materials. We describe several future avenues and applications of Cyclic DFT, including its extension to the study of non-uniform bending deformations and its possible use in the study of the nanoscale flexoelectric effect.

The Enactment of Formative Assessment in English Language Classrooms in Two Chinese Universities: Teacher and Student Responses

ERIC Educational Resources Information Center

Chen, Qiuxian; May, Lyn; Klenowski, Val; Kettle, Margaret

2014-01-01

The "College English Curriculum Requirements," announced by the Chinese Ministry of Education in 2007, recommended the inclusion of formative assessment into the existing summative assessment framework of College English. This policy had the potential to fundamentally change the nature of assessment and its role in the teaching and…

Integrating a Discovery-Based Laboratory to Teach Supply Chain Management Fundamentals in an Undergraduate Management Course

ERIC Educational Resources Information Center

Zeng, Amy; Johnson, Sharon

2009-01-01

Using experiential simulation games is a commonly used pedagogical method to enrich classroom discussions and to facilitate students' learning in supply chain management education at both undergraduate and graduate levels. However, existing games are inappropriate for undergraduate students that are first-time learners of the subject. In this…

Mineral scale management. Part II, Fundamental chemistry

Treesearch

Alan W. Rudie; Peter W. Hart

2006-01-01

The mineral scale that deposits in digesters and bleach plants is formed by a chemical precipitation process.As such, it is accurately modeled using the solubility product equilibrium constant. Although solubility product identifies the primary conditions that must be met for a scale problem to exist, the acid-base equilibria of the scaling anions often control where...

String Theory: Big Problem for Small Size

ERIC Educational Resources Information Center

Sahoo, S.

2009-01-01

String theory is the most promising candidate theory for a unified description of all the fundamental forces that exist in nature. It provides a mathematical framework that combines quantum theory with Einstein's general theory of relativity. The typical size of a string is of the order of 10[superscript -33] cm, called the Planck length. But due…

Openness, Dynamic Specialization, and the Disaggregated Future of Higher Education

ERIC Educational Resources Information Center

Wiley, David; Hilton, John, III

2009-01-01

Openness is a fundamental value underlying significant changes in society and is a prerequisite to changes institutions of higher education need to make in order to remain relevant to the society in which they exist. There are a number of ways institutions can be more open, including programs of open sharing of educational materials. Individual…

Public-Private Partnership in a Minimally Invasive Education Approach

ERIC Educational Resources Information Center

Jha, Swati; Chatterjee, Shiffon

2005-01-01

In developing countries like India, the onus of development lies mainly with the government, which faces the predicament of multiple demands and limited resources. This leads to a situation where even fundamental objectives such as basic literacy for all are not met. On the other hand, there exists a vibrant private sector, which has resources and…

Nomenclature101.com: A Free, Student-Driven Organic Chemistry Nomenclature Learning Tool

ERIC Educational Resources Information Center

Flynn, Alison B.; Caron, Jeanette; Laroche, Jamey; Daviau-Duguay, Melissa; Marcoux, Caroline; Richard, Gise`le

2014-01-01

Fundamental to a student's understanding of organic chemistry is the ability to interpret and use its language, including molecules' names and other key terms. A learning gap exists in that students often struggle with organic nomenclature. Although many resources describe the rules for naming molecules, there is a paucity of resources…

The Minor's Right to Consent to Medical Treatment: A Corollary of the Constitutional Right of Privacy

ERIC Educational Resources Information Center

Raitt, G. Emmett, Jr.

1975-01-01

Argues that the existing rules governing a physician's liability for treating a child without parental consent merit reconsideration because the minor possesses a fundamental constitutional right, stemming from the right of privacy, to consent to medical care. Proposes guidelines for the development of a legislative program implementing these…

Developing the Ecological Awareness of College and University Instructors

ERIC Educational Resources Information Center

Khasikhanov, M. S.

2008-01-01

The author maintains that present-day civilization can exist and develop only as a unity of nature, culture, and society; that a new ecological worldview must be developed to teach citizens to have a cultivated and expanded ecological awareness that is characterized by a number of fundamental features: (1) Motivation (the moral stance of the…

Student Learning Centre (SLC) Embraces the New Melbourne Model of Teaching: Facilitating Collaborative Learning

ERIC Educational Resources Information Center

Ball, Sarah

2010-01-01

Learning is about discovery and change. As schools and universities look to the future, it is fundamental that they provide environments that facilitate collaborative learning and act as points for interaction and social activity. The redevelopment of the existing Engineering Library into a Student Learning Centre (SLC) embraces the new Melbourne…

Fundamental chemistry of precipitation and mineral scale formation

Treesearch

Alan W. Rudie; Peter W. Hart

2005-01-01

The mineral scale that deposits in digesters and bleach plants is formed by a chemical precipitation process. As such, it is accurately described or modeled using the solubility product equilibrium constant. Although solubility product identifies the primary conditions that need to be met for a scale problem to exist, the acid base equilibria of the scaling anions...

Taming the remittance beast electronically.

PubMed

Moynihan, J J; Schinderle, D

1992-03-01

The next step in coralling the back-office-beast is automating remittance processing. Before taking any steps in that direction, healthcare providers need to establish new procedures for cash management and patient accounting. Opportunities exist for related uses of electronic data interchange (EDI), which will provide additional benefits but will also trigger fundamental changes in the way healthcare providers do business.

How to Identify a Domain-General Learning Mechanism when You See One

ERIC Educational Resources Information Center

Rakison, David H.; Yermolayeva, Yevdokiya

2011-01-01

A longstanding and fundamental debate in developmental science is whether knowledge is acquired through domain-specific or domain-general mechanisms. To date, there exists no tool to determine whether experimental data support one theoretical approach or the other. In this article, we argue that the U- and N-shaped curves found in a number of…

Neoliberalism, Higher Education and the Knowledge Economy: From the Free Market to Knowledge Capitalism

ERIC Educational Resources Information Center

Olssen, Mark; Peters, Michael A.

2005-01-01

The ascendancy of neoliberalism and the associated discourses of '[new public management', during the 1980s and 1990s has produced a fundamental shift in the way universities and other institutions of higher education have defined and justified their institutional existence. The traditional professional culture of open intellectual enquiry and…

Brazil, Catholic Religion and Education: Challenges and Prospects

ERIC Educational Resources Information Center

Follmann, José Ivo

2017-01-01

Taking the great change that began in the 1960s in terms of Church, society, and education in Brazil as a starting point, this article extends the existing discussion by turning its attention to three fundamental aspects of it: (1) how to manage and coordinate Catholic education; (2) how to deal with the diversification process of the religious…

Care for the Other's Selfhood: A View on Child Care and Education through Heidegger's Analytic of Dasein

ERIC Educational Resources Information Center

Joensuu, Kosti

2012-01-01

Philosophical analysis concerning selfhood and care is of fundamental importance for child care and education. Martin Heidegger's analytic of Dasein introduces the concepts of self and care within the ontological domain while structuring the holistic understanding of human existence. Because of the ontological emphasis, Heidegger's concepts of…

Rabbit Ears Concepts of Water Lone Pairs: A Reply to Comments of Hiberty, Danovich, and Shaik

ERIC Educational Resources Information Center

Clauss, A. D.; Ayoub, M.; Moore, J. W.; Landis, C. R.; Weinhold, F.

2015-01-01

This article is a response to a commentary entitled "Comment on 'Rabbit-Ears Hybrids, VSEPR Sterics, and Other Orbital Anachronisms': A Reply to a Criticism," which focuses on the fundamental question of whether there exists a unique set of supposedly "real," or "best," orbitals for a given molecule. The authors of…

Striving for Balance: The Co-Existence of Multi-, Inter- and Transdisciplinary Curricula in Information Management Education To Address Information Imbalances on Tertiary Level.

ERIC Educational Resources Information Center

Fairer-Wessels, Felicite A.

Within the South African tertiary education context, information management is taught from a variety of perspectives, including computer science, business management, informatics, and library and information science. Each discipline has a particular multidisciplinary focus dealing with its fundamentals. To investigate information management…

Mental Health: A Report of the Surgeon General. Executive Summary.

ERIC Educational Resources Information Center

Substance Abuse and Mental Health Services Administration (DHHS/PHS), Rockville, MD. Center for Mental Health Services.

This first Report of the Surgeon General on Mental Health represents the initial step in advancing the notion that mental health is fundamental to general health. It states that a review of research on mental health revealed two findings. First, the efficacy of treatment is well documented, and second, a range of treatment exists for most mental…

Wind speed effects on the quantity of Xanthomonas citri subsp. citri dispersed downwind from canopies of grapefruit trees infected with citrus canker

USDA-ARS?s Scientific Manuscript database

The epidemic of citrus canker (Xanthomonas citri subsp. citri, Xcc) in Florida continues to expand since termination of the eradication program in 2006. Storms are known to be associated with disease spread, but little information exists on the interaction of fundamental physical and biological proc...

Espanol mexicano y espanol chicano: Problemas y propuestas fundamentales (Mexican Spanish and Chicano Spanish: Fundamental Problems and Proposals).

ERIC Educational Resources Information Center

Hidalgo, Margarita

1987-01-01

Discusses the rise of Mexican Spanish as a distinct variety of Spanish and describes the regional and social dialects of contemporary Mexican Spanish. Although countless similarities exist between Mexican Spanish and the Chicano Spanish spoken in the southwestern United States, Mexican Spanish shows greater variability. (GR)

Critical Thinking as Integral to Social Work Practice

ERIC Educational Resources Information Center

Gibbons, Jill; Gray, Mel

2004-01-01

The paper examines the role of critical thinking in an experience-based model of social work education. Within this model, the development of a critical approach to our own understanding of, as well as to existing knowledge about, the world is fundamental for students and educators alike. Critical thinking is defined as more than a rational,…

Developing Common Measures in Evaluation Capacity Building: An Iterative Science and Practice Process

ERIC Educational Resources Information Center

Labin, Susan N.

2014-01-01

A fundamental reason for doing evaluation capacity building (ECB) is to improve program outcomes. Developing common measures of outcomes and the activities, processes, and factors that lead to these outcomes is an important step in moving the science and the practice of ECB forward. This article identifies a number of existing ECB measurement…

Hands on CERN: A Well-Used Physics Education Project

ERIC Educational Resources Information Center

Johansson, K. E.

2006-01-01

The "Hands on CERN" education project makes it possible for students and teachers to get close to the forefront of scientific research. The project confronts the students with contemporary physics at its most fundamental level with the help of particle collisions from the DELPHI particle physics experiment at CERN. It now exists in 14 languages…

Cross-Linguistic Differences in Bilinguals' Fundamental Frequency Ranges.

PubMed

Ordin, Mikhail; Mennen, Ineke

2017-06-10

We investigated cross-linguistic differences in fundamental frequency range (FFR) in Welsh-English bilingual speech. This is the first study that reports gender-specific behavior in switching FFRs across languages in bilingual speech. FFR was conceptualized as a behavioral pattern using measures of span (range of fundamental frequency-in semitones-covered by the speaker's voice) and level (overall height of fundamental frequency maxima, minima, and means of speaker's voice) in each language. FFR measures were taken from recordings of 30 Welsh-English bilinguals (14 women and 16 men), who read 70 semantically matched sentences, 35 in each language. Comparisons were made within speakers across languages, separately in male and female speech. Language background and language use information was elicited for qualitative analysis of extralinguistic factors that might affect the FFR. Cross-linguistic differences in FFR were found to be consistent across female bilinguals but random across male bilinguals. Most female bilinguals showed distinct FFRs for each language. Most male bilinguals, however, were found not to change their FFR when switching languages. Those who did change used different strategies than women when differentiating FFRs between languages. Detected cross-linguistic differences in FFR can be explained by sociocultural factors. Therefore, sociolinguistic factors are to be taken into account in any further study of language-specific pitch setting and cross-linguistic differences in FFR.

Cardiac structure and function in adolescent Sherpa; effect of habitual altitude and developmental stage.

PubMed

Stembridge, Mike; Ainslie, Philip N; Donnelly, Joseph; MacLeod, Nicholas T; Joshi, Suchita; Hughes, Michael G; Sherpa, Kami; Shave, Rob

2016-03-15

The purpose of this study was to examine ventricular structure and function in Sherpa adolescents to determine whether age-specific differences in oxygen saturation (SpO2 ) and pulmonary artery systolic pressure (PASP) influence cardiac adaptation to chronic hypoxia early in life. Two-dimensional, Doppler, and speckle-tracking echocardiography were performed on adolescent (9-16 yr) highland Sherpa (HLS; 3,840 m; n = 26) and compared with age-matched lowland Sherpa (LLS; 1,400 m; n = 10) and lowland Caucasian controls (LLC; sea level; n = 30). The HLS were subdivided into pre- and postadolescence; SpO2 was also recorded. Only HLS exhibited a smaller relative left ventricular (LV) end-diastolic volume; however, both HLS and LLS demonstrated a lower peak LV untwisting velocity compared with LLC (92 ± 26 and 100 ± 45 vs. 130 ± 43°/s, P < 0.05). Although SpO2 was similar between groups, PASP was higher in post- vs. preadolescent HLS (30 ± 5 vs. 25 ± 5 mmHg, P < 0.05), which negatively correlated with right ventricular strain rate (r = 0.50, P < 0.01). Much like their adult counterparts, HLS and LLS adolescents exhibit slower LV diastolic relaxation, despite residing at different altitudes. These findings suggest fundamental differences exist in the diastolic function of Sherpa that are present at an early age and may be retained after migration to lower altitudes. The higher PASP in postadolescent Sherpa is in contrast to previous reports of lowland children at high altitude and, unlike that in lowlanders, was not explained by differences in SpO2 ; thus different regulatory mechanisms seem to exist between these two distinct populations. Copyright © 2016 the American Physiological Society.

The Titan Sky Simulator ™ - Testing Prototype Balloons in Conditions Approximating those in Titan's Atmosphere

NASA Astrophysics Data System (ADS)

Nott, Julian

This paper will describe practical work flying prototype balloons in the "The Titan Sky Simulator TM " in conditions approximating those found in Titan's atmosphere. Saturn's moon, Titan, is attracting intense scientific interest. This has led to wide interest in exploring it with Aerobots, balloons or airships. Their function would be similar to the Rovers exploring Mars, but instead of moving laboriously across the rough terrain on wheels, they would float freely from location to location. To design any balloon or airship it is essential to know the temperature of the lifting gas as this influences the volume of the gas, which in turn influences the lift. To determine this temperature it is necessary to know how heat is transferred between the craft and its surroundings. Heat transfer for existing balloons is well understood. However, Titan conditions are utterly different from those in which balloons have ever been flown, so heat transfer rates cannot currently be calculated. In particular, thermal radiation accounts for most heat transfer for existing balloons but over Titan heat transfer will be dominated by convection. To be able to make these fundamental calculations, it is necessary to get fundamental experimental data. This is being obtained by flying balloons in a Simulator filled with nitrogen gas at very low temperature, about 95° K / minus 180° C, typical of Titan's temperatures. Because the gas in the Simulator is so cold, operating at atmospheric pressure the density is close to that of Titan's atmosphere. "The Titan Sky Simulator TM " has an open interior approximately 4.5 meter tall and 2.5 meters square. It has already been operated at 95° K/-180° C. By the time of the Conference it is fully expected to have data to present from actual balloons flying at this temperature. Perhaps the most important purpose of this testing is to validate numerical [computational fluid dynamics] models being developed by Tim Colonius of Caltech. These numerical models will be very valuable: once validated, a wide range of Titan aerobot designs can be analyzed rapidly. It is currently expected that Montgolfiere balloons ["hot air balloons"] will prove most suitable for Titan. However, the fundamental data obtained will be equally valuable for designing of any type of Titan Aerobot. This work is supported by the NASA Jet Propulsion Laboratory with Jeffrey Hall as program manager.

[Ethics guidelines for the creation and use of registries for biomedical research purposes].

PubMed

Abajo Iglesias, Francisco J de; Feito Grande, Lydia; Júdez Gutiérrez, Javier; Martín Arribas, M Concepción; Terracini, Benedetto; Pàmpols Ros, Teresa; Campos Castelló, Jaime; Martín Uranga, Amelia; Abascal Alonso, Moisés; Herrera Carranza, Joaquín; Sánchez Martínez, María José

2008-01-01

The clinical information stored in registries and records of different types is a fundamental tool for biomedical research. Up until just a few years ago, hardly any limitations existed on the creation and use of epidemiological registries or the use of information from pre-existing records for research purposes. This situation has changed substantially due mainly to the growing importance current laws place upon the safeguarding of the privacy and confidentiality of personal data. Although the legal framework is already quite explicit, a certain degree of leeway exists for ethical debate and prudence advice for the purpose of conducting valid, useful research with this information which will also respect the rights of the subjects and the laws in force. These guidelines deal with those aspects which have been considered relevant from an ethical standpoint in the handling of records and registries for research-related purposes, including not only the use but also the creation proper of the registries. A total of twenty-four recommendations are provided, grouped into ten sections: warranting of the creation of registry, organization and definition of responsibilities, scientific validity of the research project, ethical requirements of the collections of anonymous and anonymized data, ethical requirements of the registries including personal data, uses of medical records for research purposes, use of historical records of deceased individuals, contact with the research subjects, notification of results and review by a Research Ethics Committee.

Simultaneous Estimation of Microphysical Parameters and Atmospheric State Variables With Radar Data and Ensemble Square-root Kalman Filter

NASA Astrophysics Data System (ADS)

Tong, M.; Xue, M.

2006-12-01

An important source of model error for convective-scale data assimilation and prediction is microphysical parameterization. This study investigates the possibility of estimating up to five fundamental microphysical parameters, which are closely involved in the definition of drop size distribution of microphysical species in a commonly used single-moment ice microphysics scheme, using radar observations and the ensemble Kalman filter method. The five parameters include the intercept parameters for rain, snow and hail/graupel, and the bulk densities of hail/graupel and snow. Parameter sensitivity and identifiability are first examined. The ensemble square-root Kalman filter (EnSRF) is employed for simultaneous state and parameter estimation. OSS experiments are performed for a model-simulated supercell storm, in which the five microphysical parameters are estimated individually or in different combinations starting from different initial guesses. When error exists in only one of the microphysical parameters, the parameter can be successfully estimated without exception. The estimation of multiple parameters is found to be less robust, with end results of estimation being sensitive to the realization of the initial parameter perturbation. This is believed to be because of the reduced parameter identifiability and the existence of non-unique solutions. The results of state estimation are, however, always improved when simultaneous parameter estimation is performed, even when the estimated parameters values are not accurate.

Voltage-gated proton channel in a dinoflagellate

PubMed Central

Smith, Susan M. E.; Morgan, Deri; Musset, Boris; Cherny, Vladimir V.; Place, Allen R.; Hastings, J. Woodland; DeCoursey, Thomas E.

2011-01-01

Fogel and Hastings first hypothesized the existence of voltage-gated proton channels in 1972 in bioluminescent dinoflagellates, where they were thought to trigger the flash by activating luciferase. Proton channel genes were subsequently identified in human, mouse, and Ciona intestinalis, but their existence in dinoflagellates remained unconfirmed. We identified a candidate proton channel gene from a Karlodinium veneficum cDNA library based on homology with known proton channel genes. K. veneficum is a predatory, nonbioluminescent dinoflagellate that produces toxins responsible for fish kills worldwide. Patch clamp studies on the heterologously expressed gene confirm that it codes for a genuine voltage-gated proton channel, kHV1: it is proton-specific and activated by depolarization, its gH–V relationship shifts with changes in external or internal pH, and mutation of the selectivity filter (which we identify as Asp51) results in loss of proton-specific conduction. Indirect evidence suggests that kHV1 is monomeric, unlike other proton channels. Furthermore, kHV1 differs from all known proton channels in activating well negative to the Nernst potential for protons, EH. This unique voltage dependence makes the dinoflagellate proton channel ideally suited to mediate the proton influx postulated to trigger bioluminescence. In contrast to vertebrate proton channels, whose main function is acid extrusion, we propose that proton channels in dinoflagellates have fundamentally different functions of signaling and excitability. PMID:22006335

Evidence for the Fundamental Difference Hypothesis or Not?: Island Constraints Revisited

ERIC Educational Resources Information Center

Belikova, Alyona; White, Lydia

2009-01-01

This article examines how changes in linguistic theory affect the debate between the fundamental difference hypothesis and the access-to-Universal Grammar (UG) approach to SLA. With a focus on subjacency (Chomsky, 1973), a principle of UG that places constraints on "wh"-movement and that has frequently been taken as a test case for verifying…

40 CFR 403.13 - Variances from categorical pretreatment standards for fundamentally different factors.

Code of Federal Regulations, 2011 CFR

2011-07-01

... fundamentally different factors. (a) Definition. The term Requester means an Industrial User or a POTW or other... Pretreatment Standards, making them either more or less stringent, as they apply to a certain Industrial User within an industrial category or subcategory. This will only be done if data specific to that Industrial...

40 CFR 403.13 - Variances from categorical pretreatment standards for fundamentally different factors.

Code of Federal Regulations, 2013 CFR

2013-07-01

... fundamentally different factors. (a) Definition. The term Requester means an Industrial User or a POTW or other... Pretreatment Standards, making them either more or less stringent, as they apply to a certain Industrial User within an industrial category or subcategory. This will only be done if data specific to that Industrial...

40 CFR 403.13 - Variances from categorical pretreatment standards for fundamentally different factors.

Code of Federal Regulations, 2010 CFR

2010-07-01

... fundamentally different factors. (a) Definition. The term Requester means an Industrial User or a POTW or other... Pretreatment Standards, making them either more or less stringent, as they apply to a certain Industrial User within an industrial category or subcategory. This will only be done if data specific to that Industrial...

40 CFR 403.13 - Variances from categorical pretreatment standards for fundamentally different factors.

Code of Federal Regulations, 2014 CFR

2014-07-01

... fundamentally different factors. (a) Definition. The term Requester means an Industrial User or a POTW or other... Pretreatment Standards, making them either more or less stringent, as they apply to a certain Industrial User within an industrial category or subcategory. This will only be done if data specific to that Industrial...

The Particle Adventure | What is fundamental? | Fundamental

Science.gov Websites

Quiz - What particles are made of The four interactions How does matter interact? The unseen effect Half life Missing mass Particle decay mediators Virtual particles Different interactions Annihilations

Correlates of homophobia, transphobia, and internalized homophobia in gay or lesbian and heterosexual samples.

PubMed

Warriner, Katrina; Nagoshi, Craig T; Nagoshi, Julie L

2013-01-01

This research assessed the correlates of homophobia and transphobia in heterosexual and homosexual individuals, based on a theory of different sources of perceived symbolic threat to social status. Compared to 310 heterosexual college students, a sample of 30 gay male and 30 lesbian college students scored lower on homophobia, transphobia, and religious fundamentalism. Mean gender differences were smaller for gay men and lesbians for homophobia, aggressiveness, benevolent sexism, masculinity, and femininity. Fundamentalism, right-wing authoritarianism, and hostile and benevolent sexism were correlated only with homophobia in lesbians, whereas fundamentalism and authoritarianism were correlated only with transphobia in gay men. Correlates of internalized homophobia were different than those found for homophobia and transphobia, which was discussed in terms of gender differences in threats to status based on sexual orientation versus gender identity.

Photonic topological insulator with broken time-reversal symmetry

PubMed Central

He, Cheng; Sun, Xiao-Chen; Liu, Xiao-Ping; Lu, Ming-Hui; Chen, Yulin; Feng, Liang; Chen, Yan-Feng

2016-01-01

A topological insulator is a material with an insulating interior but time-reversal symmetry-protected conducting edge states. Since its prediction and discovery almost a decade ago, such a symmetry-protected topological phase has been explored beyond electronic systems in the realm of photonics. Electrons are spin-1/2 particles, whereas photons are spin-1 particles. The distinct spin difference between these two kinds of particles means that their corresponding symmetry is fundamentally different. It is well understood that an electronic topological insulator is protected by the electron’s spin-1/2 (fermionic) time-reversal symmetry Tf2=−1. However, the same protection does not exist under normal circumstances for a photonic topological insulator, due to photon’s spin-1 (bosonic) time-reversal symmetry Tb2=1. In this work, we report a design of photonic topological insulator using the Tellegen magnetoelectric coupling as the photonic pseudospin orbit interaction for left and right circularly polarized helical spin states. The Tellegen magnetoelectric coupling breaks bosonic time-reversal symmetry but instead gives rise to a conserved artificial fermionic-like-pseudo time-reversal symmetry, Tp (Tp2=−1), due to the electromagnetic duality. Surprisingly, we find that, in this system, the helical edge states are, in fact, protected by this fermionic-like pseudo time-reversal symmetry Tp rather than by the bosonic time-reversal symmetry Tb. This remarkable finding is expected to pave a new path to understanding the symmetry protection mechanism for topological phases of other fundamental particles and to searching for novel implementations for topological insulators. PMID:27092005

Description of quantum coherence in thermodynamic processes requires constraints beyond free energy.

PubMed

Lostaglio, Matteo; Jennings, David; Rudolph, Terry

2015-03-10

Recent studies have developed fundamental limitations on nanoscale thermodynamics, in terms of a set of independent free energy relations. Here we show that free energy relations cannot properly describe quantum coherence in thermodynamic processes. By casting time-asymmetry as a quantifiable, fundamental resource of a quantum state, we arrive at an additional, independent set of thermodynamic constraints that naturally extend the existing ones. These asymmetry relations reveal that the traditional Szilárd engine argument does not extend automatically to quantum coherences, but instead only relational coherences in a multipartite scenario can contribute to thermodynamic work. We find that coherence transformations are always irreversible. Our results also reveal additional structural parallels between thermodynamics and the theory of entanglement.

Description of quantum coherence in thermodynamic processes requires constraints beyond free energy

NASA Astrophysics Data System (ADS)

Lostaglio, Matteo; Jennings, David; Rudolph, Terry

2015-03-01

Recent studies have developed fundamental limitations on nanoscale thermodynamics, in terms of a set of independent free energy relations. Here we show that free energy relations cannot properly describe quantum coherence in thermodynamic processes. By casting time-asymmetry as a quantifiable, fundamental resource of a quantum state, we arrive at an additional, independent set of thermodynamic constraints that naturally extend the existing ones. These asymmetry relations reveal that the traditional Szilárd engine argument does not extend automatically to quantum coherences, but instead only relational coherences in a multipartite scenario can contribute to thermodynamic work. We find that coherence transformations are always irreversible. Our results also reveal additional structural parallels between thermodynamics and the theory of entanglement.

Investigation of monolithic passively mode-locked quantum dot lasers with extremely low repetition frequency.

PubMed

Xu, Tianhong; Cao, Juncheng; Montrosset, Ivo

2015-01-01

The dynamical regimes and performance optimization of quantum dot monolithic passively mode-locked lasers with extremely low repetition rate are investigated using the numerical method. A modified multisection delayed differential equation model is proposed to accomplish simulations of both two-section and three-section passively mode-locked lasers with long cavity. According to the numerical simulations, it is shown that fundamental and harmonic mode-locking regimes can be multistable over a wide current range. These dynamic regimes are studied, and the reasons for their existence are explained. In addition, we demonstrate that fundamental pulses with higher peak power can be achieved when the laser is designed to work in a region with smaller differential gain.

Existential vulnerability: toward a psychopathology of limit situations.

PubMed

Fuchs, Thomas

2013-01-01

Jaspers' concept of limit situations seems particularly appropriate not only to elucidate outstanding existential situations in general, but also basic preconditions for the occurrence of mental disorders. For this purpose, the concept is first explained in Jaspers' sense and then related to an 'existential vulnerability' of mentally ill persons that makes them experience even inconspicuous events as distressing limit situations. In such situations, an otherwise hidden fundamental condition of existence becomes manifest for them, e.g. the fragility of one's own body, the inevitability of freedom, or the finiteness of life. This fundamental condition is found unbearable and, as a reaction, gives rise to mental illness. This concept of existential vulnerability is illustrated by some psychopathological examples. © 2013 S. Karger AG, Basel.

Description of quantum coherence in thermodynamic processes requires constraints beyond free energy

PubMed Central

Lostaglio, Matteo; Jennings, David; Rudolph, Terry

2015-01-01

Recent studies have developed fundamental limitations on nanoscale thermodynamics, in terms of a set of independent free energy relations. Here we show that free energy relations cannot properly describe quantum coherence in thermodynamic processes. By casting time-asymmetry as a quantifiable, fundamental resource of a quantum state, we arrive at an additional, independent set of thermodynamic constraints that naturally extend the existing ones. These asymmetry relations reveal that the traditional Szilárd engine argument does not extend automatically to quantum coherences, but instead only relational coherences in a multipartite scenario can contribute to thermodynamic work. We find that coherence transformations are always irreversible. Our results also reveal additional structural parallels between thermodynamics and the theory of entanglement. PMID:25754774

From the Kohn-Sham band gap to the fundamental gap in solids. An integer electron approach.

PubMed

Baerends, E J

2017-06-21

It is often stated that the Kohn-Sham occupied-unoccupied gap in both molecules and solids is "wrong". We argue that this is not a correct statement. The KS theory does not allow to interpret the exact KS HOMO-LUMO gap as the fundamental gap (difference (I - A) of electron affinity (A) and ionization energy (I), twice the chemical hardness), from which it indeed differs, strongly in molecules and moderately in solids. The exact Kohn-Sham HOMO-LUMO gap in molecules is much below the fundamental gap and very close to the much smaller optical gap (first excitation energy), and LDA/GGA yield very similar gaps. In solids the situation is different: the excitation energy to delocalized excited states and the fundamental gap (I - A) are very similar, not so disparate as in molecules. Again the Kohn-Sham and LDA/GGA band gaps do not represent (I - A) but are significantly smaller. However, the special properties of an extended system like a solid make it very easy to calculate the fundamental gap from the ground state (neutral system) band structure calculations entirely within a density functional framework. The correction Δ from the KS gap to the fundamental gap originates from the response part v resp of the exchange-correlation potential and can be calculated very simply using an approximation to v resp . This affords a calculation of the fundamental gap at the same level of accuracy as other properties of crystals at little extra cost beyond the ground state bandstructure calculation. The method is based on integer electron systems, fractional electron systems (an ensemble of N- and (N + 1)-electron systems) and the derivative discontinuity are not invoked.

Emerging synthetic strategies for core cross-linked star (CCS) polymers and applications as interfacial stabilizers: bridging linear polymers and nanoparticles.

PubMed

Chen, Qijing; Cao, Xueteng; Xu, Yuanyuan; An, Zesheng

2013-10-01

Core cross-linked star (CCS) polymers become increasingly important in polymer science and are evaluated in many value-added applications. However, limitations exist to varied degrees for different synthetic methods. It is clear that improvement in synthetic efficiency is fundamental in driving this field moving even further. Here, the most recent advances are highlighted in synthetic strategies, including cross-linking with cross-linkers of low solubility, polymerization-induced self-assembly in aqueous-based heterogeneous media, and cross-linking via dynamic covalent bonds. The understanding of CCS polymers is also further refined to advocate their role as an intermediate between linear polymers and polymeric nanoparticles, and their use as interfacial stabilizers is rationalized within this context. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.