Introducing Students to Basic ChE Concepts: Four Simple Experiments.

ERIC Educational Resources Information Center

Fraser, Duncan M.

1999-01-01

Describes an Introduction to Chemical Engineering course with particular reference to the development, use, and evaluation of four simple experiments centered around the fundamental principles of heat transfer, mass transfer, reaction kinetics, and momentum transfer. (WRM)

Safety and design in airplane construction

NASA Technical Reports Server (NTRS)

Teichmann, Alfred

1934-01-01

The author gives a survey of the principles of stress analysis and design of airplane structures, and discusses the fundamental strength specifications and their effect on the stress analysis as compared with the safety factors used in other branches of engineering.

Colloquium: Modeling the dynamics of multicellular systems: Application to tissue engineering

NASA Astrophysics Data System (ADS)

Kosztin, Ioan; Vunjak-Novakovic, Gordana; Forgacs, Gabor

2012-10-01

Tissue engineering is a rapidly evolving discipline that aims at building functional tissues to improve or replace damaged ones. To be successful in such an endeavor, ideally, the engineering of tissues should be based on the principles of developmental biology. Recent progress in developmental biology suggests that the formation of tissues from the composing cells is often guided by physical laws. Here a comprehensive computational-theoretical formalism is presented that is based on experimental input and incorporates biomechanical principles of developmental biology. The formalism is described and it is shown that it correctly reproduces and predicts the quantitative characteristics of the fundamental early developmental process of tissue fusion. Based on this finding, the formalism is then used toward the optimization of the fabrication of tubular multicellular constructs, such as a vascular graft, by bioprinting, a novel tissue engineering technology.

Mechanics: Statics; A Syllabus.

ERIC Educational Resources Information Center

Compo, Louis

The instructor's guide presents material for structuring an engineering fundamentals course covering the basic laws of statistics as part of a mechanical technology program. Detailed behavioral objectives are described for the following five areas of course content: principles of mechanics, two-dimensional equilibrium, equilibrium of internal…

Semiconductor nanocrystal quantum dot synthesis approaches towards large-scale industrial production for energy applications

DOE PAGES

Hu, Michael Z.; Zhu, Ting

2015-12-04

This study reviews the experimental synthesis and engineering developments that focused on various green approaches and large-scale process production routes for quantum dots. Fundamental process engineering principles were illustrated. In relation to the small-scale hot injection method, our discussions focus on the non-injection route that could be scaled up with engineering stir-tank reactors. In addition, applications that demand to utilize quantum dots as "commodity" chemicals are discussed, including solar cells and solid-state lightings.

A Question of Interface Design: How Do Online Service GUIs Measure Up?

ERIC Educational Resources Information Center

Head, Alison J.

1997-01-01

Describes recent improvements in graphical user interfaces (GUIs) offered by online services. Highlights include design considerations, including computer engineering capabilities and users' abilities; fundamental GUI design principles; user empowerment; visual communication and interaction; and an evaluation of online search interfaces. (LRW)

Find Your Center

ERIC Educational Resources Information Center

Trauth-Nare, Amy; Pavilonis, Amy; Paganucci, Julia; Ciabattoni, Gemma; Buckley, Jenni

2016-01-01

"Mechanics" is a branch of engineering and physics that deals with forces and motion, and its fundamental principles apply to all objects, whether a bouncing ball, flowing stream, bicycle, or the human body. The field of "biomechanics" applies mechanics concepts specifically to the bodies of humans (and other animals).…

Heat Transfer Principles in Thermal Calculation of Structures in Fire

PubMed Central

Zhang, Chao; Usmani, Asif

2016-01-01

Structural fire engineering (SFE) is a relatively new interdisciplinary subject, which requires a comprehensive knowledge of heat transfer, fire dynamics and structural analysis. It is predominantly the community of structural engineers who currently carry out most of the structural fire engineering research and design work. The structural engineering curriculum in universities and colleges do not usually include courses in heat transfer and fire dynamics. In some institutions of higher education, there are graduate courses for fire resistant design which focus on the design approaches in codes. As a result, structural engineers who are responsible for structural fire safety and are competent to do their jobs by following the rules specified in prescriptive codes may find it difficult to move toward performance-based fire safety design which requires a deep understanding of both fire and heat. Fire safety engineers, on the other hand, are usually focused on fire development and smoke control, and may not be familiar with the heat transfer principles used in structural fire analysis, or structural failure analysis. This paper discusses the fundamental heat transfer principles in thermal calculation of structures in fire, which might serve as an educational guide for students, engineers and researchers. Insights on problems which are commonly ignored in performance based fire safety design are also presented. PMID:26783379

Statistical Thermodynamics and Microscale Thermophysics

NASA Astrophysics Data System (ADS)

Carey, Van P.

1999-08-01

Many exciting new developments in microscale engineering are based on the application of traditional principles of statistical thermodynamics. In this text Van Carey offers a modern view of thermodynamics, interweaving classical and statistical thermodynamic principles and applying them to current engineering systems. He begins with coverage of microscale energy storage mechanisms from a quantum mechanics perspective and then develops the fundamental elements of classical and statistical thermodynamics. Subsequent chapters discuss applications of equilibrium statistical thermodynamics to solid, liquid, and gas phase systems. The remainder of the book is devoted to nonequilibrium thermodynamics of transport phenomena and to nonequilibrium effects and noncontinuum behavior at the microscale. Although the text emphasizes mathematical development, Carey includes many examples and exercises to illustrate how the theoretical concepts are applied to systems of scientific and engineering interest. In the process he offers a fresh view of statistical thermodynamics for advanced undergraduate and graduate students, as well as practitioners, in mechanical, chemical, and materials engineering.

Augmented Reflective Learning and Knowledge Retention Perceived among Students in Classrooms Involving Virtual Laboratories

ERIC Educational Resources Information Center

Achuthan, Krishnashree; Francis, Saneesh P.; Diwakar, Shyam

2017-01-01

Learning theories converge on the principles of reflective learning processes and perceive them as fundamental to effective learning. Traditional laboratory education in science and engineering often happens in highly resource-constrained environments that compromise some of the learning objectives. This paper focuses on characterizing three…

Diesel Fundamentals. Teacher Edition (Revised).

ERIC Educational Resources Information Center

Clark, Elton; And Others

This module is one of a series of teaching guides that cover diesel mechanics. The module contains 4 sections and 19 units. Section A--Orientation includes the following units: introduction to diesel mechanics and shop safety; basic shop tools; test equipment and service tools; fasteners; bearings; and seals. Section B--Engine Principles and…

Guidelines for Implementing NCHRP 1-37A M-E Design Procedures in Ohio : Volume 3 -- Sensitivity Analysis

DOT National Transportation Integrated Search

2009-11-01

The new Mechanistic-Empirical Pavement Design Guide (NCHRP 1-37A and 1-40D) is based on fundamental engineering principles and is far more comprehensive than the current empirical AASHTO Design Guide developed for conditions more than 40 years previo...

Stem cell bioprocessing: fundamentals and principles

PubMed Central

Placzek, Mark R.; Chung, I-Ming; Macedo, Hugo M.; Ismail, Siti; Mortera Blanco, Teresa; Lim, Mayasari; Min Cha, Jae; Fauzi, Iliana; Kang, Yunyi; Yeo, David C.L.; Yip Joan Ma, Chi; Polak, Julia M.; Panoskaltsis, Nicki; Mantalaris, Athanasios

2008-01-01

In recent years, the potential of stem cell research for tissue engineering-based therapies and regenerative medicine clinical applications has become well established. In 2006, Chung pioneered the first entire organ transplant using adult stem cells and a scaffold for clinical evaluation. With this a new milestone was achieved, with seven patients with myelomeningocele receiving stem cell-derived bladder transplants resulting in substantial improvements in their quality of life. While a bladder is a relatively simple organ, the breakthrough highlights the incredible benefits that can be gained from the cross-disciplinary nature of tissue engineering and regenerative medicine (TERM) that encompasses stem cell research and stem cell bioprocessing. Unquestionably, the development of bioprocess technologies for the transfer of the current laboratory-based practice of stem cell tissue culture to the clinic as therapeutics necessitates the application of engineering principles and practices to achieve control, reproducibility, automation, validation and safety of the process and the product. The successful translation will require contributions from fundamental research (from developmental biology to the ‘omics’ technologies and advances in immunology) and from existing industrial practice (biologics), especially on automation, quality assurance and regulation. The timely development, integration and execution of various components will be critical—failures of the past (such as in the commercialization of skin equivalents) on marketing, pricing, production and advertising should not be repeated. This review aims to address the principles required for successful stem cell bioprocessing so that they can be applied deftly to clinical applications. PMID:19033137

Stem cell bioprocessing: fundamentals and principles.

PubMed

Placzek, Mark R; Chung, I-Ming; Macedo, Hugo M; Ismail, Siti; Mortera Blanco, Teresa; Lim, Mayasari; Cha, Jae Min; Fauzi, Iliana; Kang, Yunyi; Yeo, David C L; Ma, Chi Yip Joan; Polak, Julia M; Panoskaltsis, Nicki; Mantalaris, Athanasios

2009-03-06

In recent years, the potential of stem cell research for tissue engineering-based therapies and regenerative medicine clinical applications has become well established. In 2006, Chung pioneered the first entire organ transplant using adult stem cells and a scaffold for clinical evaluation. With this a new milestone was achieved, with seven patients with myelomeningocele receiving stem cell-derived bladder transplants resulting in substantial improvements in their quality of life. While a bladder is a relatively simple organ, the breakthrough highlights the incredible benefits that can be gained from the cross-disciplinary nature of tissue engineering and regenerative medicine (TERM) that encompasses stem cell research and stem cell bioprocessing. Unquestionably, the development of bioprocess technologies for the transfer of the current laboratory-based practice of stem cell tissue culture to the clinic as therapeutics necessitates the application of engineering principles and practices to achieve control, reproducibility, automation, validation and safety of the process and the product. The successful translation will require contributions from fundamental research (from developmental biology to the 'omics' technologies and advances in immunology) and from existing industrial practice (biologics), especially on automation, quality assurance and regulation. The timely development, integration and execution of various components will be critical-failures of the past (such as in the commercialization of skin equivalents) on marketing, pricing, production and advertising should not be repeated. This review aims to address the principles required for successful stem cell bioprocessing so that they can be applied deftly to clinical applications.

Liquid propellant rocket combustion instability

NASA Technical Reports Server (NTRS)

Harrje, D. T.

1972-01-01

The solution of problems of combustion instability for more effective communication between the various workers in this field is considered. The extent of combustion instability problems in liquid propellant rocket engines and recommendations for their solution are discussed. The most significant developments, both theoretical and experimental, are presented, with emphasis on fundamental principles and relationships between alternative approaches.

Liquid-propellant rocket engines health-monitoring—a survey

NASA Astrophysics Data System (ADS)

Wu, Jianjun

2005-02-01

This paper is intended to give a summary on the health-monitoring technology, which is one of the key technologies both for improving and enhancing the reliability and safety of current rocket engines and for developing new-generation high reliable reusable rocket engines. The implication of health-monitoring and the fundamental principle obeyed by the fault detection and diagnostics are elucidated. The main aspects of health-monitoring such as system frameworks, failure modes analysis, algorithms of fault detection and diagnosis, control means and advanced sensor techniques are illustrated in some detail. At last, the evolution trend of health-monitoring techniques of liquid-propellant rocket engines is set out.

Airfield construction (3rd revised and enlarged edition)

NASA Astrophysics Data System (ADS)

Goretskii, Leonid I.; Boguslavskii, Adol'f. M.; Serebrenikov, Vadim A.; Barzdo, V. I.; Leshchitskaia, T. P.; Polosin-Nikitin, S. M.

The principal engineering aspects of airfield construction are discussed. In particular, attention is given to the fundamental principles and organizational aspects of airfield construction; excavation work and airfield layout; construction of drainage systems; foundations and pavements; and quality control and safety engineering. The discussion also covers the operation of various support plants, including concrete production and mixing, production of asphalt-concrete mixtures and organic binders, production of structural steel and reinforced concrete components, and operation of stone quarries and gravel pits.

Mechanical stimulation in the engineering of heart muscle.

PubMed

Liaw, Norman Yu; Zimmermann, Wolfram-Hubertus

2016-01-15

Recreating the beating heart in the laboratory continues to be a formidable bioengineering challenge. The fundamental feature of the heart is its pumping action, requiring considerable mechanical forces to compress a blood filled chamber with a defined in- and outlet. Ventricular output crucially depends on venous loading of the ventricles (preload) and on the force generated by the preloaded ventricles to overcome arterial blood pressure (afterload). The rate of contraction is controlled by the spontaneously active sinus node and transmission of its electrical impulses into the ventricles. The underlying principles for these physiological processes are described by the Frank-Starling mechanism and Bowditch phenomenon. It is essential to consider these principles in the design and evaluation of tissue engineered myocardium. This review focuses on current strategies to evoke mechanical loading in hydrogel-based heart muscle engineering. Copyright © 2015. Published by Elsevier B.V.

The importance of meta-ethics in engineering education.

PubMed

Haws, David R

2004-04-01

Our shared moral framework is negotiated as part of the social contract. Some elements of that framework are established (tell the truth under oath), but other elements lack an overlapping consensus (just when can an individual lie to protect his or her privacy?). The tidy bits of our accepted moral framework have been codified, becoming the subject of legal rather than ethical consideration. Those elements remaining in the realm of ethics seem fragmented and inconsistent. Yet, our engineering students will need to navigate the broken ground of this complex moral landscape. A minimalist approach would leave our students with formulated dogma--principles of right and wrong such as the National Society for Professional Engineers (NSPE) Code of Ethics for Engineers--but without any insight into the genesis of these principles. A slightly deeper, micro-ethics approach would teach our students to solve ethical problems by applying heuristics--giving our students a rational process to manipulate ethical dilemmas using the same principles simply referenced a priori by dogma. A macro-ethics approach--helping students to inductively construct a posteriori principles from case studies--goes beyond the simple statement or manipulation of principles, but falls short of linking personal moral principles to the larger, social context. Ultimately, it is this social context that requires both the application of ethical principles, and the negotiation of moral values--from an understanding of meta-ethics. The approaches to engineering ethics instruction (dogma, heuristics, case studies, and meta-ethics) can be associated with stages of moral development. If we leave our students with only a dogmatic reaction to ethical dilemmas, they will be dependent on the ethical decisions of others (a denial of their fundamental potential for moral autonomy). Heuristics offers a tool to deal independently with moral questions, but a tool that too frequently reduces to casuistry when rigidly applied to "simplified" dilemmas. Case studies, while providing a context for engineering ethics, can encourage the premature analysis of specific moral conduct rather than the development of broad moral principles--stifling our students' facility with meta-ethics. Clearly, if a moral sense is developmental, ethics instruction should lead our students from lower to higher stages of moral development.

Electrochemical energy engineering: a new frontier of chemical engineering innovation.

PubMed

Gu, Shuang; Xu, Bingjun; Yan, Yushan

2014-01-01

One of the grand challenges facing humanity today is a safe, clean, and sustainable energy system where combustion no longer dominates. This review proposes that electrochemical energy conversion could set the foundation for such an energy system. It further suggests that a simple switch from an acid to a base membrane coupled with innovative cell designs may lead to a new era of affordable electrochemical devices, including fuel cells, electrolyzers, solar hydrogen generators, and redox flow batteries, for which recent progress is discussed using the authors' work as examples. It also notes that electrochemical energy engineering will likely become a vibrant subdiscipline of chemical engineering and a fertile ground for chemical engineering innovation. To realize this vision, it is necessary to incorporate fundamental electrochemistry and electrochemical engineering principles into the chemical engineering curriculum.

The Importance of Oral Communication Skills and a Graduate Course to Help Improve These Skills

ERIC Educational Resources Information Center

Wilkes, Garth L.

2012-01-01

This article addresses the importance of oral communication and many of its fundamental underlying principles. Emphasis is placed on oral presentations, particularly those used in science and engineering. Following this, the author provides a brief outline of an elective graduate level oral communications course that was developed and utilized to…

Beyond Artificial Intelligence toward Engineered Psychology

NASA Astrophysics Data System (ADS)

Bozinovski, Stevo; Bozinovska, Liljana

This paper addresses the field of Artificial Intelligence, road it went so far and possible road it should go. The paper was invited by the Conference of IT Revolutions 2008, and discusses some issues not emphasized in AI trajectory so far. The recommendations are that the main focus should be personalities rather than programs or agents, that genetic environment should be introduced in reasoning about personalities, and that limbic system should be studied and modeled. Engineered Psychology is proposed as a road to go. Need for basic principles in psychology are discussed and a mathematical equation is proposed as fundamental law of engineered and human psychology.

Nuclear Physics Made Very, Very Easy

NASA Technical Reports Server (NTRS)

Hanlen, D. F.; Morse, W. J.

1968-01-01

The fundamental approach to nuclear physics was prepared to introduce basic reactor principles to various groups of non-nuclear technical personnel associated with NERVA Test Operations. NERVA Test Operations functions as the field test group for the Nuclear Rocket Engine Program. Nuclear Engine for Rocket Vehicle Application (NERVA) program is the combined efforts of Aerojet-General Corporation as prime contractor, and Westinghouse Astronuclear Laboratory as the major subcontractor, for the assembly and testing of nuclear rocket engines. Development of the NERVA Program is under the direction of the Space Nuclear Propulsion Office, a joint agency of the U.S. Atomic Energy Commission and the National Aeronautics and Space Administration.

Advanced Pediatric Brain Imaging Research and Training Program

DTIC Science & Technology

2017-10-01

post assessment scores (combined pretest AVG =59.58% to combined post test AVG=96.78%). In 2016, the Pretest Mean result was 6.3 and Posttest mean...Sestokas (instructional designer) worked closely with the SME to continue developing e-learning courseware on the fundamental principles and...neonatology, neurology, critical care medicine, radiology, biomedical engineering, nursing, psychiatry and psychology participated. A detailed update on

Chemically-Tailored Surfaces of Silica Gel and Alumina Examined Using Color

ERIC Educational Resources Information Center

Taralp, Alpay; Buyukbayram, Gulen; Armagan, Onsel; Yalcin, Ender

2004-01-01

Color is used for studying the chemically-tailored surfaces of silica gel and alumina. When this technique of using color was applied by the students, they were able to grasp the principles of surface engineering and acquire an appreciation of its merits and at the same time they were able to learn the fundamentals of aldehyde chemistry,…

Building an experimental model of the human body with non-physiological parameters.

PubMed

Labuz, Joseph M; Moraes, Christopher; Mertz, David R; Leung, Brendan M; Takayama, Shuichi

2017-03-01

New advances in engineering and biomedical technology have enabled recent efforts to capture essential aspects of human physiology in microscale, in-vitro systems. The application of these advances to experimentally model complex processes in an integrated platform - commonly called a 'human-on-a-chip (HOC)' - requires that relevant compartments and parameters be sized correctly relative to each other and to the system as a whole. Empirical observation, theoretical treatments of resource distribution systems and natural experiments can all be used to inform rational design of such a system, but technical and fundamental challenges (e.g. small system blood volumes and context-dependent cell metabolism, respectively) pose substantial, unaddressed obstacles. Here, we put forth two fundamental principles for HOC design: inducing in-vivo -like cellular metabolic rates is necessary and may be accomplished in-vitro by limiting O 2 availability and that the effects of increased blood volumes on drug concentration can be mitigated through pharmacokinetics-based treatments of solute distribution. Combining these principles with natural observation and engineering workarounds, we derive a complete set of design criteria for a practically realizable, physiologically faithful, five-organ millionth-scale (× 10 -6 ) microfluidic model of the human body.

Building an experimental model of the human body with non-physiological parameters

PubMed Central

Labuz, Joseph M.; Moraes, Christopher; Mertz, David R.; Leung, Brendan M.; Takayama, Shuichi

2017-01-01

New advances in engineering and biomedical technology have enabled recent efforts to capture essential aspects of human physiology in microscale, in-vitro systems. The application of these advances to experimentally model complex processes in an integrated platform — commonly called a ‘human-on-a-chip (HOC)’ — requires that relevant compartments and parameters be sized correctly relative to each other and to the system as a whole. Empirical observation, theoretical treatments of resource distribution systems and natural experiments can all be used to inform rational design of such a system, but technical and fundamental challenges (e.g. small system blood volumes and context-dependent cell metabolism, respectively) pose substantial, unaddressed obstacles. Here, we put forth two fundamental principles for HOC design: inducing in-vivo-like cellular metabolic rates is necessary and may be accomplished in-vitro by limiting O2 availability and that the effects of increased blood volumes on drug concentration can be mitigated through pharmacokinetics-based treatments of solute distribution. Combining these principles with natural observation and engineering workarounds, we derive a complete set of design criteria for a practically realizable, physiologically faithful, five-organ millionth-scale (× 10−6) microfluidic model of the human body. PMID:28713851

75 FR 71317 - Fundamental Principles and Policymaking Criteria for Partnerships With Faith-Based and Other...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-22

... Part IV The President Executive Order 13559--Fundamental Principles and Policymaking Criteria for... Fundamental Principles and Policymaking Criteria for Partnerships With Faith-Based and Other Neighborhood... the following: ``Sec. 2. Fundamental Principles. In formulating and implementing policies that have...

The acquisition and transfer of knowledge of electrokinetic-hydrodynamics (EKHD) fundamentals: an introductory graduate-level course

NASA Astrophysics Data System (ADS)

Pascal, Jennifer; Tíjaro-Rojas, Rocío; Oyanader, Mario A.; Arce, Pedro E.

2017-09-01

Relevant engineering applications, such as bioseparation of proteins and DNA, soil-cleaning, motion of colloidal particles in different media, electrical field-based cancer treatments, and the cleaning of surfaces and coating flows, belongs to the family of 'Applied Field Sensitive Process Technologies' requiring an external field to move solutes in a fluid within a fibrous (or porous) domain. This field incorporates an additional variable that makes the analysis very challenging and can create for the student a number of new problems to solve. A graduate-level course, based on active-learning approaches and High Performance Learning Environments, where transfer of knowledge plays a key role, was designed by the Chemical Engineering Department at Tennessee Technological University. This course, where the fundamentals principles of EKHD were taught to science, engineering and technology students was designed by the Chemical Engineering Department at the Tennessee Technological University, Cookeville, TN. An important number of these students were able to grasp the tools required to advance their research projects that led to numerous technical presentations in professional society meetings and publications in peered-reviewed journals.

Using Inspiration from Synaptic Plasticity Rules to Optimize Traffic Flow in Distributed Engineered Networks.

PubMed

Suen, Jonathan Y; Navlakha, Saket

2017-05-01

Controlling the flow and routing of data is a fundamental problem in many distributed networks, including transportation systems, integrated circuits, and the Internet. In the brain, synaptic plasticity rules have been discovered that regulate network activity in response to environmental inputs, which enable circuits to be stable yet flexible. Here, we develop a new neuro-inspired model for network flow control that depends only on modifying edge weights in an activity-dependent manner. We show how two fundamental plasticity rules, long-term potentiation and long-term depression, can be cast as a distributed gradient descent algorithm for regulating traffic flow in engineered networks. We then characterize, both by simulation and analytically, how different forms of edge-weight-update rules affect network routing efficiency and robustness. We find a close correspondence between certain classes of synaptic weight update rules derived experimentally in the brain and rules commonly used in engineering, suggesting common principles to both.

The Syracuse University Center for Training and Research in Hypersonics

NASA Technical Reports Server (NTRS)

LaGraff, John; Blankson, Isaiah (Technical Monitor); Robinson, Stephen K. (Technical Monitor); Walsh, Michael J. (Technical Monitor); Anderson, Griffin Y. (Technical Monitor)

2000-01-01

In Fall 1993, NASA Headquarters established Centers for Hypersonics at the University of Maryland, the University of Texas-Arlington, and Syracuse University. These centers are dedicated to research and education in hypersonic technologies and have the objective of educating the next generation of engineers in this critical field. At the Syracuse University Center for Hypersonics this goal is being realized by focusing resources to: Provide an environment in which promising undergraduate students can learn the fundamental engineering principles of hypersonics so that they may make a seamless transition to graduate study and research in this field; Provide graduate students with advanced training in hypersonics and an opportunity to interact with leading authorities in the field in both research and instructional capacities; and Perform fundamental research in areas that will impact hypersonic vehicle design and development.

Atomic-scale insight and design principles for turbine engine thermal barrier coatings from theory

PubMed Central

Marino, Kristen A.; Hinnemann, Berit; Carter, Emily A.

2011-01-01

To maximize energy efficiency, gas turbine engines used in airplanes and for power generation operate at very high temperatures, even above the melting point of the metal alloys from which they are comprised. This feat is accomplished in part via the deposition of a multilayer, multicomponent thermal barrier coating (TBC), which lasts up to approximately 40,000 h before failing. Understanding failure mechanisms can aid in designing circumvention strategies. We review results of quantum mechanics calculations used to test hypotheses about impurities that harm TBCs and transition metal (TM) additives that render TBCs more robust. In particular, we discovered a number of roles that Pt and early TMs such as Hf and Y additives play in extending the lifetime of TBCs. Fundamental insight into the nature of the bonding created by such additives and its effect on high-temperature evolution of the TBCs led to design principles that can be used to create materials for even more efficient engines.

Microfabrication of Cell-Laden Hydrogels for Engineering Mineralized and Load Bearing Tissues.

PubMed

Li, Chia-Cheng; Kharaziha, Mahshid; Min, Christine; Maas, Richard; Nikkhah, Mehdi

2015-01-01

Microengineering technologies and advanced biomaterials have extensive applications in the field of regenerative medicine. In this chapter, we review the integration of microfabrication techniques and hydrogel-based biomaterials in the field of dental, bone, and cartilage tissue engineering. We primarily discuss the major features that make hydrogels attractive candidates to mimic extracellular matrix (ECM), and we consider the benefits of three-dimensional (3D) culture systems for tissue engineering applications. We then focus on the fundamental principles of microfabrication techniques including photolithography, soft lithography and bioprinting approaches. Lastly, we summarize recent research on microengineering cell-laden hydrogel constructs for dental, bone and cartilage regeneration, and discuss future applications of microfabrication techniques for load-bearing tissue engineering.

Systems Engineering Awareness

NASA Technical Reports Server (NTRS)

Lucero, John

2016-01-01

The presentation will provide an overview of the fundamentals and principles of Systems Engineering (SE). This includes understanding the processes that are used to assist the engineer in a successful design, build and implementation of solutions. The context of this presentation will be to describe the involvement of SE throughout the life-cycle of a project from cradle to grave. Due to the ever growing number of complex technical problems facing our world, a Systems Engineering approach is desirable for many reasons. The interdisciplinary technical structure of current systems, technical processes representing System Design, Technical Management and Product Realization are instrumental in the development and integration of new technologies into mainstream applications. This tutorial will demonstrate the application of SE tools to these types of problems..

Electronic circuits for communications systems: A compilation

NASA Technical Reports Server (NTRS)

1972-01-01

The compilation of electronic circuits for communications systems is divided into thirteen basic categories, each representing an area of circuit design and application. The compilation items are moderately complex and, as such, would appeal to the applications engineer. However, the rationale for the selection criteria was tailored so that the circuits would reflect fundamental design principles and applications, with an additional requirement for simplicity whenever possible.

An exploration of the biomedical optics course construction of undergraduate biomedical engineering program in medical colleges

NASA Astrophysics Data System (ADS)

Guo, Shijun; Lyu, Jie; Zhang, Peiming

2017-08-01

In this paper, the teaching goals, teaching contents and teaching methods in biomedical optics course construction are discussed. From the dimension of teaching goals, students should master the principle of optical inspection on the human body, diagnosis and treatment of methodology and instruments, through the study of the theory and practice of this course, and can utilize biomedical optics methods to solve practical problems in the clinical medical engineering practice. From the dimension of teaching contents, based on the characteristics of biomedical engineering in medical colleges, the organic integration of engineering aspects, medical optical instruments, and biomedical aspects dispersed in human anatomy, human physiology, clinical medicine fundamental related to the biomedical optics is build. Noninvasive measurement of the human body composition and noninvasive optical imaging of the human body were taken as actual problems in biomedical optics fields. Typical medical applications such as eye optics and laser medicine were also integrated into the theory and practice teaching. From the dimension of teaching methods, referencing to organ-system based medical teaching mode, optical principle and instrument principle were taught by teachers from school of medical instruments, and the histological characteristics and clinical actual need in areas such as digestive diseases and urinary surgery were taught by teachers from school of basic medicine or clinical medicine of medical colleges. Furthermore, clinical application guidance would be provided by physician and surgeons in hospitals.

47 CFR 36.2 - Fundamental principles underlying procedures.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 47 Telecommunication 2 2010-10-01 2010-10-01 false Fundamental principles underlying procedures... Fundamental principles underlying procedures. (a) The following general principles underlie the procedures... operating forces on a unit basis (e.g., conversation-minute-kilometers per message, weighted standard work...

Electrospun Fibrous Scaffolds for Tissue Engineering: Viewpoints on Architecture and Fabrication.

PubMed

Jun, Indong; Han, Hyung-Seop; Edwards, James R; Jeon, Hojeong

2018-03-06

Electrospinning has been used for the fabrication of extracellular matrix (ECM)-mimicking fibrous scaffolds for several decades. Electrospun fibrous scaffolds provide nanoscale/microscale fibrous structures with interconnecting pores, resembling natural ECM in tissues, and showing a high potential to facilitate the formation of artificial functional tissues. In this review, we summarize the fundamental principles of electrospinning processes for generating complex fibrous scaffold geometries that are similar in structural complexity to the ECM of living tissues. Moreover, several approaches for the formation of three-dimensional fibrous scaffolds arranged in hierarchical structures for tissue engineering are also presented.

Non-Hermitian engineering of single mode two dimensional laser arrays

PubMed Central

Teimourpour, Mohammad H.; Ge, Li; Christodoulides, Demetrios N.; El-Ganainy, Ramy

2016-01-01

A new scheme for building two dimensional laser arrays that operate in the single supermode regime is proposed. This is done by introducing an optical coupling between the laser array and lossy pseudo-isospectral chains of photonic resonators. The spectrum of this discrete reservoir is tailored to suppress all the supermodes of the main array except the fundamental one. This spectral engineering is facilitated by employing the Householder transformation in conjunction with discrete supersymmetry. The proposed scheme is general and can in principle be used in different platforms such as VCSEL arrays and photonic crystal laser arrays. PMID:27698355

Hydrology

NASA Astrophysics Data System (ADS)

Brutsaert, Wilfried

2005-08-01

Water in its different forms has always been a source of wonder, curiosity and practical concern for humans everywhere. Hydrology - An Introduction presents a coherent introduction to the fundamental principles of hydrology, based on the course that Wilfried Brutsaert has taught at Cornell University for the last thirty years. Hydrologic phenomena are dealt with at spatial and temporal scales at which they occur in nature. The physics and mathematics necessary to describe these phenomena are introduced and developed, and readers will require a working knowledge of calculus and basic fluid mechanics. The book will be invaluable as a textbook for entry-level courses in hydrology directed at advanced seniors and graduate students in physical science and engineering. In addition, the book will be more broadly of interest to professional scientists and engineers in hydrology, environmental science, meteorology, agronomy, geology, climatology, oceanology, glaciology and other earth sciences. Emphasis on fundamentals Clarification of the underlying physical processes Applications of fluid mechanics in the natural environment

Growth-coupled overproduction is feasible for almost all metabolites in five major production organisms

NASA Astrophysics Data System (ADS)

von Kamp, Axel; Klamt, Steffen

2017-06-01

Computational modelling of metabolic networks has become an established procedure in the metabolic engineering of production strains. One key principle that is frequently used to guide the rational design of microbial cell factories is the stoichiometric coupling of growth and product synthesis, which makes production of the desired compound obligatory for growth. Here we show that the coupling of growth and production is feasible under appropriate conditions for almost all metabolites in genome-scale metabolic models of five major production organisms. These organisms comprise eukaryotes and prokaryotes as well as heterotrophic and photoautotrophic organisms, which shows that growth coupling as a strain design principle has a wide applicability. The feasibility of coupling is proven by calculating appropriate reaction knockouts, which enforce the coupling behaviour. The study presented here is the most comprehensive computational investigation of growth-coupled production so far and its results are of fundamental importance for rational metabolic engineering.

Energy geotechnics: Advances in subsurface energy recovery, storage, exchange, and waste management

DOE PAGES

McCartney, John S.; Sanchez, Marcelo; Tomac, Ingrid

2016-02-17

Energy geotechnics involves the use of geotechnical principles to understand and engineer the coupled thermo-hydro-chemo-mechanical processes encountered in collecting, exchanging, storing, and protecting energy resources in the subsurface. In addition to research on these fundamental coupled processes and characterization of relevant material properties, applied research is being performed to develop analytical tools for the design and analysis of different geo-energy applications. In conclusion, the aims of this paper are to discuss the fundamental physics and constitutive models that are common to these different applications, and to summarize recent advances in the development of relevant analytical tools.

Energy geotechnics: Advances in subsurface energy recovery, storage, exchange, and waste management

DOE Office of Scientific and Technical Information (OSTI.GOV)

McCartney, John S.; Sanchez, Marcelo; Tomac, Ingrid

Energy geotechnics involves the use of geotechnical principles to understand and engineer the coupled thermo-hydro-chemo-mechanical processes encountered in collecting, exchanging, storing, and protecting energy resources in the subsurface. In addition to research on these fundamental coupled processes and characterization of relevant material properties, applied research is being performed to develop analytical tools for the design and analysis of different geo-energy applications. In conclusion, the aims of this paper are to discuss the fundamental physics and constitutive models that are common to these different applications, and to summarize recent advances in the development of relevant analytical tools.

Biological robustness.

PubMed

Kitano, Hiroaki

2004-11-01

Robustness is a ubiquitously observed property of biological systems. It is considered to be a fundamental feature of complex evolvable systems. It is attained by several underlying principles that are universal to both biological organisms and sophisticated engineering systems. Robustness facilitates evolvability and robust traits are often selected by evolution. Such a mutually beneficial process is made possible by specific architectural features observed in robust systems. But there are trade-offs between robustness, fragility, performance and resource demands, which explain system behaviour, including the patterns of failure. Insights into inherent properties of robust systems will provide us with a better understanding of complex diseases and a guiding principle for therapy design.

First-principles atomistic Wulff constructions for an equilibrium rutile TiO2 shape modeling

NASA Astrophysics Data System (ADS)

Jiang, Fengzhou; Yang, Lei; Zhou, Dali; He, Gang; Zhou, Jiabei; Wang, Fanhou; Chen, Zhi-Gang

2018-04-01

Identifying the exposed surfaces of rutile TiO2 crystal is crucial for its industry application and surface engineering. In this study, the shape of the rutile TiO2 was constructed by applying equilibrium thermodynamics of TiO2 crystals via first-principles density functional theory (DFT) and Wulff principles. From the DFT calculations, the surface energies of six low-index stoichiometric facets of TiO2 are determined after the calibrations of crystal structure. And then, combined surface energy calculations and Wulff principles, a geometric model of equilibrium rutile TiO2 is built up, which is coherent with the typical morphology of fully-developed equilibrium TiO2 crystal. This study provides fundamental theoretical guidance for the surface analysis and surface modification of the rutile TiO2-based materials from experimental research to industry manufacturing.

Thermodynamic Cycle Analysis of Magnetohydrodynamic-Bypass Airbreathing Hypersonic Engines

NASA Technical Reports Server (NTRS)

Litchford, Ron J.; Bityurin, Valentine A.; Lineberry, John T.

1999-01-01

Established analyses of conventional ramjet/scramjet performance characteristics indicate that a considerable decrease in efficiency can be expected at off-design flight conditions. This can be explained, in large part, by the deterioration of intake mass flow and limited inlet compression at low flight speeds and by the onset of thrust degradation effects associated with increased burner entry temperature at high flight speeds. In combination, these effects tend to impose lower and upper Mach number limits for practical flight. It has been noted, however, that Magnetohydrodynamic (MHD) energy management techniques represent a possible means for extending the flight Mach number envelope of conventional engines. By transferring enthalpy between different stages of the engine cycle, it appears that the onset of thrust degradation may be delayed to higher flight speeds. Obviously, the introduction of additional process inefficiencies is inevitable with this approach, but it is believed that these losses are more than compensated through optimization of the combustion process. The fundamental idea is to use MHD energy conversion processes to extract and bypass a portion of the intake kinetic energy around the burner. We refer to this general class of propulsion system as an MHD-bypass engine. In this paper, we quantitatively assess the performance potential and scientific feasibility of MHD-bypass airbreathing hypersonic engines using ideal gasdynamics and fundamental thermodynamic principles.

Structure and Management of an Engineering Senior Design Course.

PubMed

Tanaka, Martin L; Fischer, Kenneth J

2016-07-01

The design of products and processes is an important area in engineering. Students in engineering schools learn fundamental principles in their courses but often lack an opportunity to apply these methods to real-world problems until their senior year. This article describes important elements that should be incorporated into a senior capstone design course. It includes a description of the general principles used in engineering design and a discussion of why students often have difficulty with application and revert to trial and error methods. The structure of a properly designed capstone course is dissected and its individual components are evaluated. Major components include assessing resources, identifying projects, establishing teams, understanding requirements, developing conceptual designs, creating detailed designs, building prototypes, testing performance, and final presentations. In addition to the course design, team management and effective mentoring are critical to success. This article includes suggested guidelines and tips for effective design team leadership, attention to detail, investment of time, and managing project scope. Furthermore, the importance of understanding business culture, displaying professionalism, and considerations of different types of senior projects is discussed. Through a well-designed course and proper mentoring, students will learn to apply their engineering skills and gain basic business knowledge that will prepare them for entry-level positions in industry.

Evolutionary mechanics: new engineering principles for the emergence of flexibility in a dynamic and uncertain world.

PubMed

Whitacre, James M; Rohlfshagen, Philipp; Bender, Axel; Yao, Xin

2012-09-01

Engineered systems are designed to deftly operate under predetermined conditions yet are notoriously fragile when unexpected perturbations arise. In contrast, biological systems operate in a highly flexible manner; learn quickly adequate responses to novel conditions, and evolve new routines and traits to remain competitive under persistent environmental change. A recent theory on the origins of biological flexibility has proposed that degeneracy-the existence of multi-functional components with partially overlapping functions-is a primary determinant of the robustness and adaptability found in evolved systems. While degeneracy's contribution to biological flexibility is well documented, there has been little investigation of degeneracy design principles for achieving flexibility in systems engineering. Actually, the conditions that can lead to degeneracy are routinely eliminated in engineering design. With the planning of transportation vehicle fleets taken as a case study, this article reports evidence that degeneracy improves the robustness and adaptability of a simulated fleet towards unpredicted changes in task requirements without incurring costs to fleet efficiency. We find that degeneracy supports faster rates of design adaptation and ultimately leads to better fleet designs. In investigating the limitations of degeneracy as a design principle, we consider decision-making difficulties that arise from degeneracy's influence on fleet complexity. While global decision-making becomes more challenging, we also find degeneracy accommodates rapid distributed decision-making leading to (near-optimal) robust system performance. Given the range of conditions where favorable short-term and long-term performance outcomes are observed, we propose that degeneracy may fundamentally alter the propensity for adaptation and is useful within different engineering and planning contexts.

Simulation by bondgraphs

NASA Astrophysics Data System (ADS)

Thoma, Jean Ulrich

The fundamental principles and applications of the bond graph method, in which a system is represented on paper by letter elements and their interconnections (bonds), are presented in an introduction for engineering students. Chapters are devoted to simulation and graphical system models; bond graphs as networks for power and signal exchange; the simulation and design of mechanical engineering systems; the simulation of fluid power systems and hydrostatic devices; electrical circuits, drives, and components; practical procedures and problems of bond-graph-based numerical simulation; and applications to thermodynamics, chemistry, and biology. Also included are worked examples of applications to robotics, shocks and collisions, ac circuits, hydraulics, and a hydropneumatic fatigue-testing machine.

Nearfield acoustic holography. I - Theory of generalized holography and the development of NAH

NASA Technical Reports Server (NTRS)

Maynard, J. D.; Williams, E. G.; Lee, Y.

1985-01-01

Because its underlying principles are so fundamental, holography has been studied and applied in many areas of science. Recently, a technique has been developed which takes the maximum advantage of the fundamental principles and extracts much more information from a hologram than is customarily associated with such a measurement. In this paper the fundamental principles of holography are reviewed, and a sound radiation measurement system, called nearfield acoustic holography (NAH), which fully exploits the fundamental principles, is described.

Computer sciences

NASA Technical Reports Server (NTRS)

Smith, Paul H.

1988-01-01

The Computer Science Program provides advanced concepts, techniques, system architectures, algorithms, and software for both space and aeronautics information sciences and computer systems. The overall goal is to provide the technical foundation within NASA for the advancement of computing technology in aerospace applications. The research program is improving the state of knowledge of fundamental aerospace computing principles and advancing computing technology in space applications such as software engineering and information extraction from data collected by scientific instruments in space. The program includes the development of special algorithms and techniques to exploit the computing power provided by high performance parallel processors and special purpose architectures. Research is being conducted in the fundamentals of data base logic and improvement techniques for producing reliable computing systems.

Beyond relationships between homogeneous and heterogeneous catalysis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dixon, David A.; Katz, Alexander; Arslan, Ilke

2014-08-13

Scientists who regard catalysis as a coherent field have been striving for decades to articulate the fundamental unifying principles. But because these principles seem to be broader than chemistry, chemical engineering, and materials science combined, catalytic scientists commonly interact within the sub-domains of homogeneous, heterogeneous, and bio-catalysis, and increasingly within even narrower domains such as organocatalysis, phase-transfer catalysis, acid-base catalysis, zeolite catalysis, etc. Attempts to unify catalysis have motivated researchers to find relationships between homogeneous and heterogeneous catalysis and to mimic enzymes. These themes have inspired vibrant international meetings and workshops, and we have benefited from the idea exchanges andmore » have some thoughts about a path forward.« less

Analysis of the Lifecycle of Mechanical Engineering Products

NASA Astrophysics Data System (ADS)

Gubaydulina, R. H.; Gruby, S. V.; Davlatov, G. D.

2016-08-01

Principal phases of the lifecycle of mechanical engineering products are analyzed in the paper. The authors have developed methods and procedures to improve designing, manufacturing, operating and recycling of the machine. It has been revealed that economic lifecycle of the product is a base for appropriate organization of mechanical engineering production. This lifecycle is calculated as a minimal sum total of consumer and producer costs. The machine construction and its manufacturing technology are interrelated through a maximal possible company profit. The products are to be recycled by their producer. Recycling should be considered as a feedback phase, necessary to make the whole lifecycle of the product a constantly functioning self-organizing system. The principles, outlined in this paper can be used as fundamentals to develop an automated PLM-system.

The role of failure/problems in engineering: A commentary of failures experienced - lessons learned

NASA Technical Reports Server (NTRS)

Ryan, R. S.

1992-01-01

The written version of a series of seminars given to several aerospace companies and three NASA centers are presented. The results are lessons learned through a study of the problems experienced in 35 years of engineering. The basic conclusion is that the primary cause of problems has not been mission technologies, as important as technology is, but the neglect of basic principles. Undergirding this is the lack of a systems focus from determining requirements through design, verification, and operations phases. Many of the concepts discussed are fundamental to total quality management (TQM) and can be used to augment this product enhanced philosophy. Fourteen principles are addressed with problems experienced and are used as examples. Included is a discussion of the implication of constraints, poorly defined requirements, and schedules. Design guidelines, lessons learned, and future tasks are listed. Two additional sections are included that deal with personal lessons learned and thoughts on future thrusts (TQM).

Principles, Techniques, and Applications of Tissue Microfluidics

NASA Technical Reports Server (NTRS)

Wade, Lawrence A.; Kartalov, Emil P.; Shibata, Darryl; Taylor, Clive

2011-01-01

The principle of tissue microfluidics and its resultant techniques has been applied to cell analysis. Building microfluidics to suit a particular tissue sample would allow the rapid, reliable, inexpensive, highly parallelized, selective extraction of chosen regions of tissue for purposes of further biochemical analysis. Furthermore, the applicability of the techniques ranges beyond the described pathology application. For example, they would also allow the posing and successful answering of new sets of questions in many areas of fundamental research. The proposed integration of microfluidic techniques and tissue slice samples is called "tissue microfluidics" because it molds the microfluidic architectures in accordance with each particular structure of each specific tissue sample. Thus, microfluidics can be built around the tissues, following the tissue structure, or alternatively, the microfluidics can be adapted to the specific geometry of particular tissues. By contrast, the traditional approach is that microfluidic devices are structured in accordance with engineering considerations, while the biological components in applied devices are forced to comply with these engineering presets.

Fundamental Design Principles for Transcription-Factor-Based Metabolite Biosensors.

PubMed

Mannan, Ahmad A; Liu, Di; Zhang, Fuzhong; Oyarzún, Diego A

2017-10-20

Metabolite biosensors are central to current efforts toward precision engineering of metabolism. Although most research has focused on building new biosensors, their tunability remains poorly understood and is fundamental for their broad applicability. Here we asked how genetic modifications shape the dose-response curve of biosensors based on metabolite-responsive transcription factors. Using the lac system in Escherichia coli as a model system, we built promoter libraries with variable operator sites that reveal interdependencies between biosensor dynamic range and response threshold. We developed a phenomenological theory to quantify such design constraints in biosensors with various architectures and tunable parameters. Our theory reveals a maximal achievable dynamic range and exposes tunable parameters for orthogonal control of dynamic range and response threshold. Our work sheds light on fundamental limits of synthetic biology designs and provides quantitative guidelines for biosensor design in applications such as dynamic pathway control, strain optimization, and real-time monitoring of metabolism.

Synthetic immunology: modulating the human immune system.

PubMed

Geering, Barbara; Fussenegger, Martin

2015-02-01

Humans have manipulated the immune system to dampen or boost the immune response for thousands of years. As our understanding of fundamental immunology and biotechnological methodology accumulates, we can capitalize on this combined knowledge to engineer biological devices with the aim of rationally manipulating the immune response. We address therapeutic approaches based on the principles of synthetic immunology that either ameliorate disorders of the immune system by interfering with the immune response, or improve diverse pathogenic conditions by exploiting immune cell effector functions. We specifically highlight synthetic proteins investigated in preclinical and clinical trials, summarize studies that have used engineered immune cells, and finish with a discussion of possible future therapeutic concepts. Copyright © 2014 Elsevier Ltd. All rights reserved.

Fundamentals handbook of electrical and computer engineering. Volume 1 Circuits fields and electronics

NASA Astrophysics Data System (ADS)

Chang, S. S. L.

State of the art technology in circuits, fields, and electronics is discussed. The principles and applications of these technologies to industry, digital processing, microwave semiconductors, and computer-aided design are explained. Important concepts and methodologies in mathematics and physics are reviewed, and basic engineering sciences and associated design methods are dealt with, including: circuit theory and the design of magnetic circuits and active filter synthesis; digital signal processing, including FIR and IIR digital filter design; transmission lines, electromagnetic wave propagation and surface acoustic wave devices. Also considered are: electronics technologies, including power electronics, microwave semiconductors, GaAs devices, and magnetic bubble memories; digital circuits and logic design.

Limits on fundamental limits to computation.

PubMed

Markov, Igor L

2014-08-14

An indispensable part of our personal and working lives, computing has also become essential to industries and governments. Steady improvements in computer hardware have been supported by periodic doubling of transistor densities in integrated circuits over the past fifty years. Such Moore scaling now requires ever-increasing efforts, stimulating research in alternative hardware and stirring controversy. To help evaluate emerging technologies and increase our understanding of integrated-circuit scaling, here I review fundamental limits to computation in the areas of manufacturing, energy, physical space, design and verification effort, and algorithms. To outline what is achievable in principle and in practice, I recapitulate how some limits were circumvented, and compare loose and tight limits. Engineering difficulties encountered by emerging technologies may indicate yet unknown limits.

Translational research-the need of a new bioethics approach.

PubMed

Hostiuc, Sorin; Moldoveanu, Alin; Dascălu, Maria-Iuliana; Unnthorsson, Runar; Jóhannesson, Ómar I; Marcus, Ioan

2016-01-15

Translational research tries to apply findings from basic science to enhance human health and well-being. Many phases of the translational research may include non-medical tasks (information technology, engineering, nanotechnology, biochemistry, animal research, economy, sociology, psychology, politics, and so on). Using common bioethics principles to these areas might sometimes be not feasible, or even impossible. However, the whole process must respect some fundamental, moral principles. The purpose of this paper is to argument the need for a different approach to the morality in translational bioethics, and to suggest some directions that might be followed when constructing such a bioethics. We will show that a new approach is needed and present a few ethical issues that are specific to the translational research.

The "Fundamental Pedogagical Principle" in Second Language Teaching.

ERIC Educational Resources Information Center

Krashen, Stephen D.

1981-01-01

A fundamental principle of second language acquisition is stated and applied to language teaching. The principle states that learners acquire a second language when they receive comprehensible input in situations where their affective filters are sufficiently low. The theoretical background of this principle consists of five hypotheses: the…

Biomedical engineering strategies in system design space.

PubMed

Savageau, Michael A

2011-04-01

Modern systems biology and synthetic bioengineering face two major challenges in relating properties of the genetic components of a natural or engineered system to its integrated behavior. The first is the fundamental unsolved problem of relating the digital representation of the genotype to the analog representation of the parameters for the molecular components. For example, knowing the DNA sequence does not allow one to determine the kinetic parameters of an enzyme. The second is the fundamental unsolved problem of relating the parameters of the components and the environment to the phenotype of the global system. For example, knowing the parameters does not tell one how many qualitatively distinct phenotypes are in the organism's repertoire or the relative fitness of the phenotypes in different environments. These also are challenges for biomedical engineers as they attempt to develop therapeutic strategies to treat pathology or to redirect normal cellular functions for biotechnological purposes. In this article, the second of these fundamental challenges will be addressed, and the notion of a "system design space" for relating the parameter space of components to the phenotype space of bioengineering systems will be focused upon. First, the concept of a system design space will be motivated by introducing one of its key components from an intuitive perspective. Second, a simple linear example will be used to illustrate a generic method for constructing the design space in which qualitatively distinct phenotypes can be identified and counted, their fitness analyzed and compared, and their tolerance to change measured. Third, two examples of nonlinear systems from different areas of biomedical engineering will be presented. Finally, after giving reference to a few other applications that have made use of the system design space approach to reveal important design principles, some concluding remarks concerning challenges and opportunities for further development will be made.

2016 TSRC Summer School on Fundamental Science for Alternative Energy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Batista, Victor S.

The 2016 TSRC Summer School on Fundamental Science for Alternative Energy introduced principles, methods, and approaches relevant to the design of molecular transformations, energy transduction, and current applications for alternative energy. Energy and environment are likely to be key themes that will dominate the way science and engineering develop over the next few decades. Only an interdisciplinary approach with a team-taught structure as presented at the 2016 TSRC Summer School can be expected to succeed in the face of problems of such difficulty. The course inspired a new generation of 24 graduate students and 2 post-docs to continue work inmore » the field, or at least to have something of an insider's point of view as the field develops in the next few decades.« less

Thermographic Phosphors for High Temperature Measurements: Principles, Current State of the Art and Recent Applications

PubMed Central

Khalid, Ashiq Hussain; Kontis, Konstantinos

2008-01-01

This paper reviews the state of phosphor thermometry, focusing on developments in the past 15 years. The fundamental principles and theory are presented, and the various spectral and temporal modes, including the lifetime decay, rise time and intensity ratio, are discussed. The entire phosphor measurement system, including relative advantages to conventional methods, choice of phosphors, bonding techniques, excitation sources and emission detection, is reviewed. Special attention is given to issues that may arise at high temperatures. A number of recent developments and applications are surveyed, with examples including: measurements in engines, hypersonic wind tunnel experiments, pyrolysis studies and droplet/spray/gas temperature determination. They show the technique is flexible and successful in measuring temperatures where conventional methods may prove to be unsuitable. PMID:27873836

Principles of thermoacoustic energy harvesting

NASA Astrophysics Data System (ADS)

Avent, A. W.; Bowen, C. R.

2015-11-01

Thermoacoustics exploit a temperature gradient to produce powerful acoustic pressure waves. The technology has a key role to play in energy harvesting systems. A time-line in the development of thermoacoustics is presented from its earliest recorded example in glass blowing through to the development of the Sondhauss and Rijke tubes to Stirling engines and pulse-tube cryo-cooling. The review sets the current literature in context, identifies key publications and promising areas of research. The fundamental principles of thermoacoustic phenomena are explained; design challenges and factors influencing efficiency are explored. Thermoacoustic processes involve complex multi-physical coupling and transient, highly non-linear relationships which are computationally expensive to model; appropriate numerical modelling techniques and options for analyses are presented. Potential methods of harvesting the energy in the acoustic waves are also examined.

Magnetism: Principles and Applications

NASA Astrophysics Data System (ADS)

Craik, Derek J.

2003-09-01

If you are studying physics, chemistry, materials science, electrical engineering, information technology or medicine, then you'll know that understanding magnetism is fundamental to success in your studies and here is the key to unlocking the mysteries of magnetism....... You can: obtain a simple overview of magnetism, including the roles of B and H, resonances and special techniques take full advantage of modern magnets with a wealth of expressions for fields and forces develop realistic general design programmes using isoparametric finite elements study the subtleties of the general theory of magnetic moments and their dynamics follow the development of outstanding materials appreciate how magnetism encompasses topics as diverse as rock magnetism, chemical reaction rates, biological compasses, medical therapies, superconductivity and levitation understand the basis and remarkable achievements of magnetic resonance imaging In his new book, Magnetism, Derek Craik throws light on the principles and applications of this fascinating subject. From formulae for calculating fields to quantum theory, the secrets of magnetism are exposed, ensuring that whether you are a chemist or engineer, physicist, medic or materials scientist Magnetism is the book for our course.

Developments in the Tools and Methodologies of Synthetic Biology

PubMed Central

Kelwick, Richard; MacDonald, James T.; Webb, Alexander J.; Freemont, Paul

2014-01-01

Synthetic biology is principally concerned with the rational design and engineering of biologically based parts, devices, or systems. However, biological systems are generally complex and unpredictable, and are therefore, intrinsically difficult to engineer. In order to address these fundamental challenges, synthetic biology is aiming to unify a “body of knowledge” from several foundational scientific fields, within the context of a set of engineering principles. This shift in perspective is enabling synthetic biologists to address complexity, such that robust biological systems can be designed, assembled, and tested as part of a biological design cycle. The design cycle takes a forward-design approach in which a biological system is specified, modeled, analyzed, assembled, and its functionality tested. At each stage of the design cycle, an expanding repertoire of tools is being developed. In this review, we highlight several of these tools in terms of their applications and benefits to the synthetic biology community. PMID:25505788

Nanomanufacturing-related programs at NSF

NASA Astrophysics Data System (ADS)

Cooper, Khershed P.

2015-08-01

The National Science Foundation is meeting the challenge of transitioning lab-scale nanoscience and technology to commercial-scale through several nanomanufacturing-related research programs. The goal of the core Nanomanufacturing (NM) and the inter-disciplinary Scalable Nanomanufacturing (SNM) programs is to meet the barriers to manufacturability at the nano-scale by developing the fundamental principles for the manufacture of nanomaterials, nanostructures, nanodevices, and engineered nanosystems. These programs address issues such as scalability, reliability, quality, performance, yield, metrics, and cost, among others. The NM and SNM programs seek nano-scale manufacturing ideas that are transformative, that will be widely applicable and that will have far-reaching technological and societal impacts. It is envisioned that the results from these basic research programs will provide the knowledge base for larger programs such as the manufacturing Nanotechnology Science and Engineering Centers (NSECs) and the Nanosystems Engineering Research Centers (NERCs). Besides brief descriptions of these different programs, this paper will include discussions on novel

The Impact of Biomechanics in Tissue Engineering and Regenerative Medicine

PubMed Central

Butler, David L.; Goldstein, Steven A.; Guo, X. Edward; Kamm, Roger; Laurencin, Cato T.; McIntire, Larry V.; Mow, Van C.; Nerem, Robert M.; Sah, Robert L.; Soslowsky, Louis J.; Spilker, Robert L.; Tranquillo, Robert T.

2009-01-01

Biomechanical factors profoundly influence the processes of tissue growth, development, maintenance, degeneration, and repair. Regenerative strategies to restore damaged or diseased tissues in vivo and create living tissue replacements in vitro have recently begun to harness advances in understanding of how cells and tissues sense and adapt to their mechanical environment. It is clear that biomechanical considerations will be fundamental to the successful development of clinical therapies based on principles of tissue engineering and regenerative medicine for a broad range of musculoskeletal, cardiovascular, craniofacial, skin, urinary, and neural tissues. Biomechanical stimuli may in fact hold the key to producing regenerated tissues with high strength and endurance. However, many challenges remain, particularly for tissues that function within complex and demanding mechanical environments in vivo. This paper reviews the present role and potential impact of experimental and computational biomechanics in engineering functional tissues using several illustrative examples of past successes and future grand challenges. PMID:19583462

Modeling Complex Cross-Systems Software Interfaces Using SysML

NASA Technical Reports Server (NTRS)

Mandutianu, Sanda; Morillo, Ron; Simpson, Kim; Liepack, Otfrid; Bonanne, Kevin

2013-01-01

The complex flight and ground systems for NASA human space exploration are designed, built, operated and managed as separate programs and projects. However, each system relies on one or more of the other systems in order to accomplish specific mission objectives, creating a complex, tightly coupled architecture. Thus, there is a fundamental need to understand how each system interacts with the other. To determine if a model-based system engineering approach could be utilized to assist with understanding the complex system interactions, the NASA Engineering and Safety Center (NESC) sponsored a task to develop an approach for performing cross-system behavior modeling. This paper presents the results of applying Model Based Systems Engineering (MBSE) principles using the System Modeling Language (SysML) to define cross-system behaviors and how they map to crosssystem software interfaces documented in system-level Interface Control Documents (ICDs).

Prelude to corneal tissue engineering – Gaining control of collagen organization

PubMed Central

Ruberti, Jeffrey W.; Zieske, James D.

2012-01-01

By most standard engineering practice principles, it is premature to credibly discuss the “engineering” of a human cornea. A professional design engineer would assert that we still do not know what a cornea is (and correctly so), therefore we cannot possibly build one. The proof resides in the fact that there are no clinically viable corneas based on classical tissue engineering methods available. This is possibly because tissue engineering in the classical sense (seeding a degradable scaffolding with a population synthetically active cells) does not produce conditions which support the generation of organized tissue. Alternative approaches to the problem are in their infancy and include the methods which attempt to recapitulate development or to produce corneal stromal analogs de novo which require minimal remodeling. Nonetheless, tissue engineering efforts, which have been focused on producing the fundamental functional component of a cornea (organized alternating arrays of collagen or “lamellae”) may have already provided valuable new insights and tools relevant to development, growth, remodeling and pathologies associated with connective tissue in general. This is because engineers ask a fundamentally different question (How can that be done?) than do biological scientists (How is that done?). The difference in inquiry has prompted us to closely examine (and to mimic) development as well as investigate collagen physicochemical behavior so that we may exert control over organization both in cell-culture (in vitro) and on the benchtop (de novo). Our initial results indicate that reproducing corneal stroma-like local and long-range organization of collagen may be simpler than we anticipated while controlling spacing and fibril morphology remains difficult, but perhaps not impossible in the (reasonably) near term. PMID:18775789

The Biotechnology Facility for International Space Station.

PubMed

Goodwin, Thomas; Lundquist, Charles; Tuxhorn, Jennifer; Hurlbert, Katy

2004-03-01

The primary mission of the Cellular Biotechnology Program is to advance microgravity as a tool in basic and applied cell biology. The microgravity environment can be used to study fundamental principles of cell biology and to achieve specific applications such as tissue engineering. The Biotechnology Facility (BTF) will provide a state-of-the-art facility to perform cellular biotechnology research onboard the International Space Station (ISS). The BTF will support continuous operation, which will allow performance of long-duration experiments and will significantly increase the on-orbit science throughput.

Development and fabrication of high strength alloy fibers for use in metal-metal matrix composites

NASA Technical Reports Server (NTRS)

King, G. W.; Petrasek, D. W.

1979-01-01

Metal fiber reinforced superalloys are being considered for construction of critical components in turbine engines that operate at high temperature. The problems involved in fabricating refractory metal alloys into wire form in such a manner as to maximize their strength properties without developing excessive structural defects are described. The fundamental principles underlying the development of such alloy fibers are also briefly discussed. The progress made to date in developing tungsten, tantalum and columbium base alloys for fiber reinforcement is reported and future prospects for alloy fiber development considered.

The Biotechnology Facility for International Space Station

NASA Technical Reports Server (NTRS)

Goodwin, Thomas; Lundquist, Charles; Tuxhorn, Jennifer; Hurlbert, Katy

2004-01-01

The primary mission of the Cellular Biotechnology Program is to advance microgravity as a tool in basic and applied cell biology. The microgravity environment can be used to study fundamental principles of cell biology and to achieve specific applications such as tissue engineering. The Biotechnology Facility (BTF) will provide a state-of-the-art facility to perform cellular biotechnology research onboard the International Space Station (ISS). The BTF will support continuous operation, which will allow performance of long-duration experiments and will significantly increase the on-orbit science throughput.

Fluid Dynamics for Physicists

NASA Astrophysics Data System (ADS)

Faber, T. E.

1995-08-01

This textbook provides an accessible and comprehensive account of fluid dynamics that emphasizes fundamental physical principles and stresses connections with other branches of physics. Beginning with a basic introduction, the book goes on to cover many topics not typically treated in texts, such as compressible flow and shock waves, sound attenuation and bulk viscosity, solitary waves and ship waves, thermal convection, instabilities, turbulence, and the behavior of anisotropic, non-Newtonian and quantum fluids. Undergraduate or graduate students in physics or engineering who are taking courses in fluid dynamics will find this book invaluable.

Optimization of a yeast RNA interference system for controlling gene expression and enabling rapid metabolic engineering.

PubMed

Crook, Nathan C; Schmitz, Alexander C; Alper, Hal S

2014-05-16

Reduction of endogenous gene expression is a fundamental operation of metabolic engineering, yet current methods for gene knockdown (i.e., genome editing) remain laborious and slow, especially in yeast. In contrast, RNA interference allows facile and tunable gene knockdown via a simple plasmid transformation step, enabling metabolic engineers to rapidly prototype knockdown strategies in multiple strains before expending significant cost to undertake genome editing. Although RNAi is naturally present in a myriad of eukaryotes, it has only been recently implemented in Saccharomyces cerevisiae as a heterologous pathway and so has not yet been optimized as a metabolic engineering tool. In this study, we elucidate a set of design principles for the construction of hairpin RNA expression cassettes in yeast and implement RNA interference to quickly identify routes for improvement of itaconic acid production in this organism. The approach developed here enables rapid prototyping of knockdown strategies and thus accelerates and reduces the cost of the design-build-test cycle in yeast.

A computer model for liquid jet atomization in rocket thrust chambers

NASA Astrophysics Data System (ADS)

Giridharan, M. G.; Lee, J. G.; Krishnan, A.; Yang, H. Q.; Ibrahim, E.; Chuech, S.; Przekwas, A. J.

1991-12-01

The process of atomization has been used as an efficient means of burning liquid fuels in rocket engines, gas turbine engines, internal combustion engines, and industrial furnaces. Despite its widespread application, this complex hydrodynamic phenomenon has not been well understood, and predictive models for this process are still in their infancy. The difficulty in simulating the atomization process arises from the relatively large number of parameters that influence it, including the details of the injector geometry, liquid and gas turbulence, and the operating conditions. In this study, numerical models are developed from first principles, to quantify factors influencing atomization. For example, the surface wave dynamics theory is used for modeling the primary atomization and the droplet energy conservation principle is applied for modeling the secondary atomization. The use of empirical correlations has been minimized by shifting the analyses to fundamental levels. During applications of these models, parametric studies are performed to understand and correlate the influence of relevant parameters on the atomization process. The predictions of these models are compared with existing experimental data. The main tasks of this study were the following: development of a primary atomization model; development of a secondary atomization model; development of a model for impinging jets; development of a model for swirling jets; and coupling of the primary atomization model with a CFD code.

The Wyss institute: A new model for medical technology innovation and translation across the academic-industrial interface.

PubMed

Tolikas, Mary; Antoniou, Ayis; Ingber, Donald E

2017-09-01

The Wyss Institute for Biologically Inspired Engineering at Harvard University was formed based on the recognition that breakthrough discoveries cannot change the world if they never leave the laboratory. The Institute's mission is to discover the biological principles that Nature uses to build living things, and to harness these insights to create biologically inspired engineering innovations to advance human health and create a more sustainable world. Since its launch in 2009, the Institute has developed a new model for innovation, collaboration, and technology translation within academia, breaking "silos" to enable collaborations that cross institutional and disciplinary barriers. Institute faculty and staff engage in high-risk research that leads to transformative breakthroughs. The biological principles uncovered are harnessed to develop new engineering solutions for medicine and healthcare, as well as nonmedical areas, such as energy, architecture, robotics, and manufacturing. These technologies are translated into commercial products and therapies through collaborations with clinical investigators, corporate alliances, and the formation of new start-ups that are driven by a unique internal business development team including entrepreneurs-in-residence with domain-specific expertise. Here, we describe this novel organizational model that the Institute has developed to change the paradigm of how fundamental discovery, medical technology innovation, and commercial translation are carried out at the academic-industrial interface.

Quantum correlations are tightly bound by the exclusivity principle.

PubMed

Yan, Bin

2013-06-28

It is a fundamental problem in physics of what principle limits the correlations as predicted by our current description of nature, based on quantum mechanics. One possible explanation is the "global exclusivity" principle recently discussed in Phys. Rev. Lett. 110, 060402 (2013). In this work we show that this principle actually has a much stronger restriction on the probability distribution. We provide a tight constraint inequality imposed by this principle and prove that this principle singles out quantum correlations in scenarios represented by any graph. Our result implies that the exclusivity principle might be one of the fundamental principles of nature.

Role of strategic planning in engineering management

NASA Technical Reports Server (NTRS)

Krishen, Kumar

1993-01-01

Today, more than ever before, engineers are faced with uncertain and sometimes chaotic environments in which to function. The traditional roles of an engineer to design, develop, and streamline a manufacturing process for a product are still valued and relevant. However, the need for an engineer to participate in the process of identifying the product to be developed, the schedule and resources required, and the goal of satisfying the customer, has become paramount to achieving the success of the enterprise. When we include these endeavors in the functions of an engineer, management of 'engineering' takes on a new dimension. In this paper, the ramifications of the changing and increased functions of an engineer and consequent impacts on engineering management are explored. The basic principles which should be invoked in order to embrace the new environment for engineering management are outlined. The ultimate finding of this study is that the enterprise strategic plan should be developed in such a way as to allow engineering management to encompass the full spectrum of the responsibilities of engineers. A consequence of this is that the fundamental elements of the strategic process can best be implemented through a project team or group approach. The paper thus concentrates on three areas: evolving environment, strategic plan, and ways to achieve enterprise success.

Principles, Techniques, and Applications of Tissue Microfluidics

NASA Technical Reports Server (NTRS)

Wade, Lawrence A.; Kartalov, Emil P.; Shibata, Darryl; Taylor, Clive

2011-01-01

The principle of tissue microfluidics and its resultant techniques has been applied to cell analysis. Building microfluidics to suit a particular tissue sample would allow the rapid, reliable, inexpensive, highly parallelized, selective extraction of chosen regions of tissue for purposes of further biochemical analysis. Furthermore, the applicability of the techniques ranges beyond the described pathology application. For example, they would also allow the posing and successful answering of new sets of questions in many areas of fundamental research. The proposed integration of microfluidic techniques and tissue slice samples is called tissue microfluidics because it molds the microfluidic architectures in accordance with each particular structure of each specific tissue sample. Thus, microfluidics can be built around the tissues, following the tissue structure, or alternatively, the microfluidics can be adapted to the specific geometry of particular tissues. By contrast, the traditional approach is that microfluidic devices are structured in accordance with engineering considerations, while the biological components in applied devices are forced to comply with these engineering presets. The proposed principles represent a paradigm shift in microfluidic technology in three important ways: Microfluidic devices are to be directly integrated with, onto, or around tissue samples, in contrast to the conventional method of off-chip sample extraction followed by sample insertion in microfluidic devices. Architectural and operational principles of microfluidic devices are to be subordinated to suit specific tissue structure and needs, in contrast to the conventional method of building devices according to fluidic function alone and without regard to tissue structure. Sample acquisition from tissue is to be performed on-chip and is to be integrated with the diagnostic measurement within the same device, in contrast to the conventional method of off-chip sample prep and subsequent insertion into a diagnostic device. A more advanced form of tissue integration with microfluidics is tissue encapsulation, wherein the sample is completely encapsulated within a microfluidic device, to allow for full surface access. The immediate applications of these approaches lie with diagnostics of tissue slices and biopsy samples e.g. for cancer but the approaches would also be very useful in comparative genomics and other areas of fundamental research involving heterogeneous tissue samples.

Guidelines for developing vectorizable computer programs

NASA Technical Reports Server (NTRS)

Miner, E. W.

1982-01-01

Some fundamental principles for developing computer programs which are compatible with array-oriented computers are presented. The emphasis is on basic techniques for structuring computer codes which are applicable in FORTRAN and do not require a special programming language or exact a significant penalty on a scalar computer. Researchers who are using numerical techniques to solve problems in engineering can apply these basic principles and thus develop transportable computer programs (in FORTRAN) which contain much vectorizable code. The vector architecture of the ASC is discussed so that the requirements of array processing can be better appreciated. The "vectorization" of a finite-difference viscous shock-layer code is used as an example to illustrate the benefits and some of the difficulties involved. Increases in computing speed with vectorization are illustrated with results from the viscous shock-layer code and from a finite-element shock tube code. The applicability of these principles was substantiated through running programs on other computers with array-associated computing characteristics, such as the Hewlett-Packard (H-P) 1000-F.

Glossary of Terms

MedlinePlus

... 2019 Basic and Clinical Science Course, Section 02: Fundamentals and Principles of Ophthalmology 2018-2019 Basic and ... 2019 Basic and Clinical Science Course, Section 02: Fundamentals and Principles of Ophthalmology Print 2018-2019 Basic ...

Energy Literacy : Essential Principles and Fundamental Concepts for Energy Education

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

Energy Literacy: Essential Principles and Fundamental Concepts for Energy Education presents energy concepts that, if understood and applied, will help individuals and communities make informed energy decisions.

Engineering coherence among excited states in synthetic heterodimer systems.

PubMed

Hayes, Dugan; Griffin, Graham B; Engel, Gregory S

2013-06-21

The design principles that support persistent electronic coherence in biological light-harvesting systems are obscured by the complexity of such systems. Some electronic coherences in these systems survive for hundreds of femtoseconds at physiological temperatures, suggesting that coherent dynamics may play a role in photosynthetic energy transfer. Coherent effects may increase energy transfer efficiency relative to strictly incoherent transfer mechanisms. Simple, tractable, manipulable model systems are required in order to probe the fundamental physics underlying these persistent electronic coherences, but to date, these quantum effects have not been observed in small molecules. We have engineered a series of rigid synthetic heterodimers that can serve as such a model system and observed quantum beating signals in their two-dimensional electronic spectra consistent with the presence of persistent electronic coherences.

The Uses of Big Data in Cities.

PubMed

Bettencourt, Luís M A

2014-03-01

There is much enthusiasm currently about the possibilities created by new and more extensive sources of data to better understand and manage cities. Here, I explore how big data can be useful in urban planning by formalizing the planning process as a general computational problem. I show that, under general conditions, new sources of data coordinated with urban policy can be applied following fundamental principles of engineering to achieve new solutions to important age-old urban problems. I also show that comprehensive urban planning is computationally intractable (i.e., practically impossible) in large cities, regardless of the amounts of data available. This dilemma between the need for planning and coordination and its impossibility in detail is resolved by the recognition that cities are first and foremost self-organizing social networks embedded in space and enabled by urban infrastructure and services. As such, the primary role of big data in cities is to facilitate information flows and mechanisms of learning and coordination by heterogeneous individuals. However, processes of self-organization in cities, as well as of service improvement and expansion, must rely on general principles that enforce necessary conditions for cities to operate and evolve. Such ideas are the core of a developing scientific theory of cities, which is itself enabled by the growing availability of quantitative data on thousands of cities worldwide, across different geographies and levels of development. These three uses of data and information technologies in cities constitute then the necessary pillars for more successful urban policy and management that encourages, and does not stifle, the fundamental role of cities as engines of development and innovation in human societies.

Electric-field noise from carbon-adatom diusion on a Au(110) surface: first-principles calculations and experiments

NASA Astrophysics Data System (ADS)

Sadeghpour, Hossein; Kim, Eunja; Safavi-Naini, Arghavan; Weck, Philippe; Hite, Dustin; McKay, Kyle; Pappas, David

2017-04-01

The decoherence of trapped-ion quantum gates due to heating of their motional modes is a fundamental science and engineering challenge. Mitigating this noise, is fundamental to efficient and scalable operations in ion microtraps. To understand heating at the trap-electrode surfaces, we investigate the possible source of noise by focusing on the diffusion of carbon-containing adsorbates onto the Au(110) surface. Using density functional theory and detailed scanning probe microscopy, we show that the diffusive motion of carbon adatom on gold surface significantly affect the energy landscape and adatom dipole moment variation. A model for the diffusion noise, which varies quadratically with the variation of the dipole moment, qualitatively reproduces the measured noise spectrum, and the estimate of the noise spectral density is in accord with measured values.

NASA Systems Engineering Handbook

NASA Technical Reports Server (NTRS)

Hirshorn, Steven R.; Voss, Linda D.; Bromley, Linda K.

2017-01-01

The update of this handbook continues the methodology of the previous revision: a top-down compatibility with higher level Agency policy and a bottom-up infusion of guidance from the NASA practitioners in the field. This approach provides the opportunity to obtain best practices from across NASA and bridge the information to the established NASA systems engineering processes and to communicate principles of good practice as well as alternative approaches rather than specify a particular way to accomplish a task. The result embodied in this handbook is a top-level implementation approach on the practice of systems engineering unique to NASA. Material used for updating this handbook has been drawn from many sources, including NPRs, Center systems engineering handbooks and processes, other Agency best practices, and external systems engineering textbooks and guides. This handbook consists of six chapters: (1) an introduction, (2) a systems engineering fundamentals discussion, (3) the NASA program project life cycles, (4) systems engineering processes to get from a concept to a design, (5) systems engineering processes to get from a design to a final product, and (6) crosscutting management processes in systems engineering. The chapters are supplemented by appendices that provide outlines, examples, and further information to illustrate topics in the chapters. The handbook makes extensive use of boxes and figures to define, refine, illustrate, and extend concepts in the chapters.

The Role of Fisher Information Theory in the Development of Fundamental Laws in Physical Chemistry

ERIC Educational Resources Information Center

Honig, J. M.

2009-01-01

The unifying principle that involves rendering the Fisher information measure an extremum is reviewed. It is shown that with this principle, in conjunction with appropriate constraints, a large number of fundamental laws can be derived from a common source in a unified manner. The resulting economy of thought pertaining to fundamental principles…

Challenges in engineering osteochondral tissue grafts with hierarchical structures.

PubMed

Gadjanski, Ivana; Vunjak-Novakovic, Gordana

2015-01-01

A major hurdle in treating osteochondral (OC) defects is the different healing abilities of two types of tissues involved - articular cartilage and subchondral bone. Biomimetic approaches to OC-construct engineering, based on recapitulation of biological principles of tissue development and regeneration, have potential for providing new treatments and advancing fundamental studies of OC tissue repair. This review on state of the art in hierarchical OC tissue graft engineering is focused on tissue engineering approaches designed to recapitulate the native milieu of cartilage and bone development. These biomimetic systems are discussed with relevance to bioreactor cultivation of clinically sized, anatomically shaped human cartilage/bone constructs with physiologic stratification and mechanical properties. The utility of engineered OC tissue constructs is evaluated for their use as grafts in regenerative medicine, and as high-fidelity models in biological research. A major challenge in engineering OC tissues is to generate a functionally integrated stratified cartilage-bone structure starting from one single population of mesenchymal cells, while incorporating perfusable vasculature into the bone, and in bone-cartilage interface. To this end, new generations of advanced scaffolds and bioreactors, implementation of mechanical loading regimens and harnessing of inflammatory responses of the host will likely drive the further progress.

Do Racial and Gender Disparities Exist in Newer Glaucoma Treatments?

MedlinePlus

... 2019 Basic and Clinical Science Course, Section 02: Fundamentals and Principles of Ophthalmology 2018-2019 Basic and ... 2019 Basic and Clinical Science Course, Section 02: Fundamentals and Principles of Ophthalmology Print 2018-2019 Basic ...

Orbital motion (3rd revised and enlarged edition)

NASA Astrophysics Data System (ADS)

Roy, A. E.

The fundamental principles of celestial mechanics are discussed in an introduction for students of astronomy, aerospace engineering, and geography. Chapters are devoted to the dynamic structure of the universe, coordinate and timekeeping systems, the reduction of observational data, the two-body problem, the many-body problem, general and special perturbations, and the stability and evolution of the solar system. Consideration is given to lunar theory, artificial satellites, rocket dynamics and transfer orbits, interplanetary and lunar trajectories, orbit determination and interplanetary navigation, binaries and other few-body systems, and many-body systems of stars. Diagrams, graphs, tables, and problems with solutions are provided.

Cellular automaton supercomputing

NASA Technical Reports Server (NTRS)

Wolfram, Stephen

1987-01-01

Many of the models now used in science and engineering are over a century old. And most of them can be implemented on modern digital computers only with considerable difficulty. Some new basic models are discussed which are much more directly suitable for digital computer simulation. The fundamental principle is that the models considered herein are as suitable as possible for implementation on digital computers. It is then a matter of scientific analysis to determine whether such models can reproduce the behavior seen in physical and other systems. Such analysis was carried out in several cases, and the results are very encouraging.

Ethical principles in health research and review process.

PubMed

Tangwa, Godfrey B

2009-11-01

In this paper I want to reflect on the fundamental ethical principles and their application in different particular contexts, especially in health research and the ethics review process. Four fundamental ethical principles have been identified and widely discussed in bioethical literature. These principles namely are: autonomy or respect for others, beneficence, non-maleficence and justice. These principles have cross-cultural validity, relevance and applicability. Every real-life situation and every concrete particular case in which ethical decision-making is called-for is unique and different from all others; but the same fundamental ethical principles are relevant and used in addressing all such cases and situations. Very often ethical problems will present themselves in the form of dilemmas and it is then necessary to use the same fundamental principles to analyze the situations, to argue persuasively and cogently with competence for the best options or choices in such situations. The issues I will be dealing with in this paper are necessarily more abstract and theoretical, but we will be discussing them from a very practical viewpoint and impulse, with a view to application in concrete real-life situations. The paper ends with some sample practical examples of cases that the reader can use to test his/her grasp of the principles, how to apply them, how to balance them in differing situations and contexts and how to adjudicate between them when they seem to be in conflict.

Fundamental uncertainty limit of optical flow velocimetry according to Heisenberg's uncertainty principle.

PubMed

Fischer, Andreas

2016-11-01

Optical flow velocity measurements are important for understanding the complex behavior of flows. Although a huge variety of methods exist, they are either based on a Doppler or a time-of-flight measurement principle. Doppler velocimetry evaluates the velocity-dependent frequency shift of light scattered at a moving particle, whereas time-of-flight velocimetry evaluates the traveled distance of a scattering particle per time interval. Regarding the aim of achieving a minimal measurement uncertainty, it is unclear if one principle allows to achieve lower uncertainties or if both principles can achieve equal uncertainties. For this reason, the natural, fundamental uncertainty limit according to Heisenberg's uncertainty principle is derived for Doppler and time-of-flight measurement principles, respectively. The obtained limits of the velocity uncertainty are qualitatively identical showing, e.g., a direct proportionality for the absolute value of the velocity to the power of 32 and an indirect proportionality to the square root of the scattered light power. Hence, both measurement principles have identical potentials regarding the fundamental uncertainty limit due to the quantum mechanical behavior of photons. This fundamental limit can be attained (at least asymptotically) in reality either with Doppler or time-of-flight methods, because the respective Cramér-Rao bounds for dominating photon shot noise, which is modeled as white Poissonian noise, are identical with the conclusions from Heisenberg's uncertainty principle.

Particle Engineering of Excipients for Direct Compression: Understanding the Role of Material Properties.

PubMed

Mangal, Sharad; Meiser, Felix; Morton, David; Larson, Ian

2015-01-01

Tablets represent the preferred and most commonly dispensed pharmaceutical dosage form for administering active pharmaceutical ingredients (APIs). Minimizing the cost of goods and improving manufacturing output efficiency has motivated companies to use direct compression as a preferred method of tablet manufacturing. Excipients dictate the success of direct compression, notably by optimizing powder formulation compactability and flow, thus there has been a surge in creating excipients specifically designed to meet these needs for direct compression. Greater scientific understanding of tablet manufacturing coupled with effective application of the principles of material science and particle engineering has resulted in a number of improved direct compression excipients. Despite this, significant practical disadvantages of direct compression remain relative to granulation, and this is partly due to the limitations of direct compression excipients. For instance, in formulating high-dose APIs, a much higher level of excipient is required relative to wet or dry granulation and so tablets are much bigger. Creating excipients to enable direct compression of high-dose APIs requires the knowledge of the relationship between fundamental material properties and excipient functionalities. In this paper, we review the current understanding of the relationship between fundamental material properties and excipient functionality for direct compression.

The Wyss institute: A new model for medical technology innovation and translation across the academic‐industrial interface

PubMed Central

Tolikas, Mary; Antoniou, Ayis

2017-01-01

Abstract The Wyss Institute for Biologically Inspired Engineering at Harvard University was formed based on the recognition that breakthrough discoveries cannot change the world if they never leave the laboratory. The Institute's mission is to discover the biological principles that Nature uses to build living things, and to harness these insights to create biologically inspired engineering innovations to advance human health and create a more sustainable world. Since its launch in 2009, the Institute has developed a new model for innovation, collaboration, and technology translation within academia, breaking “silos” to enable collaborations that cross institutional and disciplinary barriers. Institute faculty and staff engage in high‐risk research that leads to transformative breakthroughs. The biological principles uncovered are harnessed to develop new engineering solutions for medicine and healthcare, as well as nonmedical areas, such as energy, architecture, robotics, and manufacturing. These technologies are translated into commercial products and therapies through collaborations with clinical investigators, corporate alliances, and the formation of new start‐ups that are driven by a unique internal business development team including entrepreneurs‐in‐residence with domain‐specific expertise. Here, we describe this novel organizational model that the Institute has developed to change the paradigm of how fundamental discovery, medical technology innovation, and commercial translation are carried out at the academic‐industrial interface. PMID:29313034

Developing Research Capabilities in Energy Biosciences: Design principles of photosynthetic biofuel production.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Donald D. Brown; David Savage

2012-06-30

The current fossil fuel-based energy infrastructure is not sustainable. Solar radiation is a plausible alternative, but realizing it as such will require significant technological advances in the ability to harvest light energy and convert it into suitable fuels. The biological system of photosynthesis can carry out these reactions, and in principle could be engineered using the tools of synthetic biology. One desirable implementation would be to rewire the reactions of a photosynthetic bacterium to direct the energy harvested from solar radiation into the synthesis of the biofuel H2. Proposed here is a series of experiments to lay the basic sciencemore » groundwork for such an attempt. The goal is to elucidate the transcriptional network of photosynthesis using a novel driver-reporter screen, evolve more robust hydrogenases for improved catalysis, and to test the ability of the photosynthetic machinery to directly produce H2 in vivo. The results of these experiments will have broad implications for the understanding of photosynthesis, enzyme function, and the engineering of biological systems for sustainable energy production. The ultimate impact could be a fundamental transformation of the world's energy economy.« less

Dynamic sealing principles

NASA Technical Reports Server (NTRS)

Zuk, J.

1976-01-01

The fundamental principles governing dynamic sealing operation are discussed. Different seals are described in terms of these principles. Despite the large variety of detailed construction, there appear to be some basic principles, or combinations of basic principles, by which all seals function, these are presented and discussed. Theoretical and practical considerations in the application of these principles are discussed. Advantages, disadvantages, limitations, and application examples of various conventional and special seals are presented. Fundamental equations governing liquid and gas flows in thin film seals, which enable leakage calculations to be made, are also presented. Concept of flow functions, application of Reynolds lubrication equation, and nonlubrication equation flow, friction and wear; and seal lubrication regimes are explained.

Rainfall: State of the Science

NASA Astrophysics Data System (ADS)

Testik, Firat Y.; Gebremichael, Mekonnen

Rainfall: State of the Science offers the most up-to-date knowledge on the fundamental and practical aspects of rainfall. Each chapter, self-contained and written by prominent scientists in their respective fields, provides three forms of information: fundamental principles, detailed overview of current knowledge and description of existing methods, and emerging techniques and future research directions. The book discusses • Rainfall microphysics: raindrop morphodynamics, interactions, size distribution, and evolution • Rainfall measurement and estimation: ground-based direct measurement (disdrometer and rain gauge), weather radar rainfall estimation, polarimetric radar rainfall estimation, and satellite rainfall estimation • Statistical analyses: intensity-duration-frequency curves, frequency analysis of extreme events, spatial analyses, simulation and disaggregation, ensemble approach for radar rainfall uncertainty, and uncertainty analysis of satellite rainfall products The book is tailored to be an indispensable reference for researchers, practitioners, and graduate students who study any aspect of rainfall or utilize rainfall information in various science and engineering disciplines.

Redesigning metabolism based on orthogonality principles

PubMed Central

Pandit, Aditya Vikram; Srinivasan, Shyam; Mahadevan, Radhakrishnan

2017-01-01

Modifications made during metabolic engineering for overproduction of chemicals have network-wide effects on cellular function due to ubiquitous metabolic interactions. These interactions, that make metabolic network structures robust and optimized for cell growth, act to constrain the capability of the cell factory. To overcome these challenges, we explore the idea of an orthogonal network structure that is designed to operate with minimal interaction between chemical production pathways and the components of the network that produce biomass. We show that this orthogonal pathway design approach has significant advantages over contemporary growth-coupled approaches using a case study on succinate production. We find that natural pathways, fundamentally linked to biomass synthesis, are less orthogonal in comparison to synthetic pathways. We suggest that the use of such orthogonal pathways can be highly amenable for dynamic control of metabolism and have other implications for metabolic engineering. PMID:28555623

Molecular biomimetics: nanotechnology through biology.

PubMed

Sarikaya, Mehmet; Tamerler, Candan; Jen, Alex K-Y; Schulten, Klaus; Baneyx, François

2003-09-01

Proteins, through their unique and specific interactions with other macromolecules and inorganics, control structures and functions of all biological hard and soft tissues in organisms. Molecular biomimetics is an emerging field in which hybrid technologies are developed by using the tools of molecular biology and nanotechnology. Taking lessons from biology, polypeptides can now be genetically engineered to specifically bind to selected inorganic compounds for applications in nano- and biotechnology. This review discusses combinatorial biological protocols, that is, bacterial cell surface and phage-display technologies, in the selection of short sequences that have affinity to (noble) metals, semiconducting oxides and other technological compounds. These genetically engineered proteins for inorganics (GEPIs) can be used in the assembly of functional nanostructures. Based on the three fundamental principles of molecular recognition, self-assembly and DNA manipulation, we highlight successful uses of GEPI in nanotechnology.

Engineering responsive supramolecular biomaterials: Toward smart therapeutics.

PubMed

Webber, Matthew J

2016-09-01

Engineering materials using supramolecular principles enables generalizable and modular platforms that have tunable chemical, mechanical, and biological properties. Applying this bottom-up, molecular engineering-based approach to therapeutic design affords unmatched control of emergent properties and functionalities. In preparing responsive materials for biomedical applications, the dynamic character of typical supramolecular interactions facilitates systems that can more rapidly sense and respond to specific stimuli through a fundamental change in material properties or characteristics, as compared to cases where covalent bonds must be overcome. Several supramolecular motifs have been evaluated toward the preparation of "smart" materials capable of sensing and responding to stimuli. Triggers of interest in designing materials for therapeutic use include applied external fields, environmental changes, biological actuators, applied mechanical loading, and modulation of relative binding affinities. In addition, multistimuli-responsive routes can be realized that capture combinations of triggers for increased functionality. In sum, supramolecular engineering offers a highly functional strategy to prepare responsive materials. Future development and refinement of these approaches will improve precision in material formation and responsiveness, seek dynamic reciprocity in interactions with living biological systems, and improve spatiotemporal sensing of disease for better therapeutic deployment.

Induction of angiogenesis in tissue-engineered scaffolds designed for bone repair: a combined gene therapy-cell transplantation approach.

PubMed

Jabbarzadeh, Ehsan; Starnes, Trevor; Khan, Yusuf M; Jiang, Tao; Wirtel, Anthony J; Deng, Meng; Lv, Qing; Nair, Lakshmi S; Doty, Steven B; Laurencin, Cato T

2008-08-12

One of the fundamental principles underlying tissue engineering approaches is that newly formed tissue must maintain sufficient vascularization to support its growth. Efforts to induce vascular growth into tissue-engineered scaffolds have recently been dedicated to developing novel strategies to deliver specific biological factors that direct the recruitment of endothelial cell (EC) progenitors and their differentiation. The challenge, however, lies in orchestration of the cells, appropriate biological factors, and optimal factor doses. This study reports an approach as a step forward to resolving this dilemma by combining an ex vivo gene transfer strategy and EC transplantation. The utility of this approach was evaluated by using 3D poly(lactide-co-glycolide) (PLAGA) sintered microsphere scaffolds for bone tissue engineering applications. Our goal was achieved by isolation and transfection of adipose-derived stromal cells (ADSCs) with adenovirus encoding the cDNA of VEGF. We demonstrated that the combination of VEGF releasing ADSCs and ECs results in marked vascular growth within PLAGA scaffolds. We thereby delineate the potential of ADSCs to promote vascular growth into biomaterials.

Induction of angiogenesis in tissue-engineered scaffolds designed for bone repair: A combined gene therapy–cell transplantation approach

PubMed Central

Jabbarzadeh, Ehsan; Starnes, Trevor; Khan, Yusuf M.; Jiang, Tao; Wirtel, Anthony J.; Deng, Meng; Lv, Qing; Nair, Lakshmi S.; Doty, Steven B.; Laurencin, Cato T.

2008-01-01

One of the fundamental principles underlying tissue engineering approaches is that newly formed tissue must maintain sufficient vascularization to support its growth. Efforts to induce vascular growth into tissue-engineered scaffolds have recently been dedicated to developing novel strategies to deliver specific biological factors that direct the recruitment of endothelial cell (EC) progenitors and their differentiation. The challenge, however, lies in orchestration of the cells, appropriate biological factors, and optimal factor doses. This study reports an approach as a step forward to resolving this dilemma by combining an ex vivo gene transfer strategy and EC transplantation. The utility of this approach was evaluated by using 3D poly(lactide-co-glycolide) (PLAGA) sintered microsphere scaffolds for bone tissue engineering applications. Our goal was achieved by isolation and transfection of adipose-derived stromal cells (ADSCs) with adenovirus encoding the cDNA of VEGF. We demonstrated that the combination of VEGF releasing ADSCs and ECs results in marked vascular growth within PLAGA scaffolds. We thereby delineate the potential of ADSCs to promote vascular growth into biomaterials. PMID:18678895

Artistic and Industrial Institutions in Russian Education Structure in First Quarter of XXth Century

NASA Astrophysics Data System (ADS)

Chernyh, D. G.

2017-11-01

The article tells about the formation of Russian design education in the XXth century. It focuses on the peculiar features and causes of its insufficient effectiveness in the historical context. It studies the dynamics of changes in the priorities related to the artistic and industrial education in Russia and the connection of these processes with socio-political transformations. The article identifies the role of constructivist artists in the formation and approbation of advanced design-engineering techniques. It emphasizes the interdisciplinary essence of the profession of a designer as a special kind of design activities, its organizing, consolidating and progressive origin in the sphere of industrial production and carrying out interdisciplinary studies. It discloses the essence of a new “engineer-artist” profession. It briefly describes the influence of the fundamental principle of design - projectivity, on engineering and design disciplines when the interaction of an artist, an engineer and an architect is achieved on the basis of design, arrangement and inventive art as well as production organization where science and technology form the basis for creative work.

Review of the Usefulness of Various Rotational Seismometers with Laboratory Results of Fibre-Optic Ones Tested for Engineering Applications

PubMed Central

Jaroszewicz, Leszek R.; Kurzych, Anna; Krajewski, Zbigniew; Marć, Paweł; Kowalski, Jerzy K.; Bobra, Piotr; Zembaty, Zbigniew; Sakowicz, Bartosz; Jankowski, Robert

2016-01-01

Starting with descriptions of rotational seismology, areas of interest and historical field measurements, the fundamental requirements for rotational seismometers for seismological and engineering application are formulated. On the above basis, a review of all existing rotational seismometers is presented with a description of the principles of their operation as well as possibilities to fulfill formulated requirements. This review includes mechanical, acoustical, electrochemical and optical devices and shows that the last of these types are the most promising. It is shown that optical rotational seismometer based on the ring-laser gyroscope concept is the best for seismological applications, whereas systems based on fiber-optic gyroscopes demonstrate parameters which are also required for engineering applications. Laboratory results of the Fibre-Optic System for Rotational Events & Phenomena Monitoring using a small 1-D shaking table modified to generate rotational excitations are presented. The harmonic and time-history tests demonstrate its usefulness for recording rotational motions with rates up to 0.25 rad/s. PMID:27999299

Review and analysis of avionic helmet-mounted displays

NASA Astrophysics Data System (ADS)

Li, Hua; Zhang, Xin; Shi, Guangwei; Qu, Hemeng; Wu, Yanxiong; Zhang, Jianping

2013-11-01

With the development of new concepts and principles over the past century, helmet-mounted displays (HMDs) have been widely applied. This paper presents a review of avionic HMDs and shows some areas of active and intensive research. This review is focused on the optical design aspects and is divided into three sections to explore new optical design methods, which include an off-axis design, design with freeform optical surface, and design with holographic optical waveguide technology. Building on the fundamentals of optical design and engineering, the principles section primarily expounds on the five optical system parameters, which include weight, field of view, modulation transfer function, exit pupil size, and eye relief. We summarized the previous design works using new components to achieve compact and lightweight HMDs. Moreover, the paper presents a partial summary of the more notable experimental, prototype, fielded, and future HMD fixed-wing and rotary-wing programs.

Principles of assembly reveal a periodic table of protein complexes.

PubMed

Ahnert, Sebastian E; Marsh, Joseph A; Hernández, Helena; Robinson, Carol V; Teichmann, Sarah A

2015-12-11

Structural insights into protein complexes have had a broad impact on our understanding of biological function and evolution. In this work, we sought a comprehensive understanding of the general principles underlying quaternary structure organization in protein complexes. We first examined the fundamental steps by which protein complexes can assemble, using experimental and structure-based characterization of assembly pathways. Most assembly transitions can be classified into three basic types, which can then be used to exhaustively enumerate a large set of possible quaternary structure topologies. These topologies, which include the vast majority of observed protein complex structures, enable a natural organization of protein complexes into a periodic table. On the basis of this table, we can accurately predict the expected frequencies of quaternary structure topologies, including those not yet observed. These results have important implications for quaternary structure prediction, modeling, and engineering. Copyright © 2015, American Association for the Advancement of Science.

Adaptation of sensor morphology: an integrative view of perception from biologically inspired robotics perspective

PubMed Central

Nurzaman, Surya G.

2016-01-01

Sensor morphology, the morphology of a sensing mechanism which plays a role of shaping the desired response from physical stimuli from surroundings to generate signals usable as sensory information, is one of the key common aspects of sensing processes. This paper presents a structured review of researches on bioinspired sensor morphology implemented in robotic systems, and discusses the fundamental design principles. Based on literature review, we propose two key arguments: first, owing to its synthetic nature, biologically inspired robotics approach is a unique and powerful methodology to understand the role of sensor morphology and how it can evolve and adapt to its task and environment. Second, a consideration of an integrative view of perception by looking into multidisciplinary and overarching mechanisms of sensor morphology adaptation across biology and engineering enables us to extract relevant design principles that are important to extend our understanding of the unfinished concepts in sensing and perception. PMID:27499843

10 Tips to Reduce Your Chance of Losing Vision from the Most Common Cause of Blindness

MedlinePlus

... 2019 Basic and Clinical Science Course, Section 02: Fundamentals and Principles of Ophthalmology 2018-2019 Basic and ... 2019 Basic and Clinical Science Course, Section 02: Fundamentals and Principles of Ophthalmology Print 2018-2019 Basic ...

Current and future regenerative medicine — Principles, concepts, and therapeutic use of stem cell therapy and tissue engineering in equine medicine

PubMed Central

Koch, Thomas G.; Berg, Lise C.; Betts, Dean H.

2009-01-01

This paper provides a bird’s-eye perspective of the general principles of stem-cell therapy and tissue engineering; it relates comparative knowledge in this area to the current and future status of equine regenerative medicine. The understanding of equine stem cell biology, biofactors, and scaffolds, and their potential therapeutic use in horses are rudimentary at present. Mesenchymal stem cell isolation has been proclaimed from several equine tissues in the past few years. Based on the criteria of the International Society for Cellular Therapy, most of these cells are more correctly referred to as multipotent mesenchymal stromal cells, unless there is proof that they exhibit the fundamental in vivo characteristics of pluripotency and the ability to self-renew. That said, these cells from various tissues hold great promise for therapeutic use in horses. The 3 components of tissue engineering — cells, biological factors, and biomaterials — are increasingly being applied in equine medicine, fuelled by better scaffolds and increased understanding of individual biofactors and cell sources. The effectiveness of stem cell-based therapies and most tissue engineering concepts has not been demonstrated sufficiently in controlled clinical trials in equine patients to be regarded as evidence-based medicine. In the meantime, the medical mantra “do no harm” should prevail, and the application of stem cell-based therapies in the horse should be done critically and cautiously, and treatment outcomes (good and bad) should be recorded and reported. Stem cell and tissue engineering research in the horse has exciting comparative and equine specific perspectives that most likely will benefit the health of horses and humans. Controlled, well-designed studies are needed to move this new equine research field forward. PMID:19412395

Principles of liquids working in heat engines

PubMed Central

Allen, P. C.; Knight, W. R.; Paulson, D. N.; Wheatley, J. C.

1980-01-01

The thermodynamic and thermophysical properties of liquids suggest that they should be powerful working fluids in heat engines. Their use requires heat engines based conceptually on the Stirling and Malone principles. The principles are explained, and then experiments on propylene are presented that demonstrate the principles and confirm the thermodynamic analysis. PMID:16592756

Military Curriculum Materials for Vocational and Technical Education. Engine Principles, 8-3. Edition 5.

ERIC Educational Resources Information Center

Ohio State Univ., Columbus. National Center for Research in Vocational Education.

This individualized, self-paced course for independent study in engine principles has been adapted from military curriculum materials for vocational education use. The course provides the student with basic information on engine principles including different kinds of combustion engines, lubrication systems, and cooling systems. It is organized…

Fundamental Tactical Principles of Soccer: A Comparison of Different Age Groups

PubMed Central

Guilherme, José; Rechenchosky, Leandro; da Costa, Luciane Cristina Arantes; Rinadi, Wilson

2017-01-01

Abstract The fundamental tactical principles of the game of soccer represent a set of action rules that guide behaviours related to the management of game space. The aim of this study was to compare the performance of fundamental offensive and defensive tactical principles among youth soccer players from 12 to 17 years old. The sample consisted of 3689 tactical actions performed by 48 soccer players in three age categories: under 13 (U-13), under 15 (U-15), and under 17 (U-17). Tactical performance was measured using the System of Tactical Assessment in Soccer (FUT-SAT). The Kruskal Wallis, Mann-Whitney U, Friedman, Wilcoxon, and Cohen’s Kappa tests were used in the study analysis. The results showed that the principles of “offensive coverage” (p = 0.01) and “concentration” (p = 0.04) were performed more frequently by the U-17 players than the U-13 players. The tactical principles “width and length” (p < 0.05) and “defensive unit” (p < 0.05) were executed more frequently by younger soccer players. It can be concluded that the frequency with which fundamental tactical principles are performed varies between the gaming categories, which implies that there is valuation of defensive security and a progressive increase in “offensive coverage” caused by increased confidence and security in offensive actions. PMID:28828091

Fundamental Tactical Principles of Soccer: A Comparison of Different Age Groups.

PubMed

Borges, Paulo Henrique; Guilherme, José; Rechenchosky, Leandro; da Costa, Luciane Cristina Arantes; Rinadi, Wilson

2017-09-01

The fundamental tactical principles of the game of soccer represent a set of action rules that guide behaviours related to the management of game space. The aim of this study was to compare the performance of fundamental offensive and defensive tactical principles among youth soccer players from 12 to 17 years old. The sample consisted of 3689 tactical actions performed by 48 soccer players in three age categories: under 13 (U-13), under 15 (U-15), and under 17 (U-17). Tactical performance was measured using the System of Tactical Assessment in Soccer (FUT-SAT). The Kruskal Wallis, Mann-Whitney U, Friedman, Wilcoxon, and Cohen's Kappa tests were used in the study analysis. The results showed that the principles of "offensive coverage" (p = 0.01) and "concentration" (p = 0.04) were performed more frequently by the U-17 players than the U-13 players. The tactical principles "width and length" (p < 0.05) and "defensive unit" (p < 0.05) were executed more frequently by younger soccer players. It can be concluded that the frequency with which fundamental tactical principles are performed varies between the gaming categories, which implies that there is valuation of defensive security and a progressive increase in "offensive coverage" caused by increased confidence and security in offensive actions.

Fundamentals of Pharmacogenetics in Personalized, Precision Medicine.

PubMed

Valdes, Roland; Yin, DeLu Tyler

2016-09-01

This article introduces fundamental principles of pharmacogenetics as applied to personalized and precision medicine. Pharmacogenetics establishes relationships between pharmacology and genetics by connecting phenotypes and genotypes in predicting the response of therapeutics in individual patients. We describe differences between precision and personalized medicine and relate principles of pharmacokinetics and pharmacodynamics to applications in laboratory medicine. We also review basic principles of pharmacogenetics, including its evolution, how it enables the practice of personalized therapeutics, and the role of the clinical laboratory. These fundamentals are a segue for understanding specific clinical applications of pharmacogenetics described in subsequent articles in this issue. Copyright © 2016 Elsevier Inc. All rights reserved.

[The input of medical community into development of fundamental principles of Zemstvo medicine of Russia].

PubMed

Yegorysheva, I V

2013-01-01

The article considers the participation of medical community in formation of fundamental principles of unique system of public health--the Zemstvo medicine. This occurrence found its reflexion in activities of medical scientific societies and congresses, periodic medical mass media.

Challenges in engineering osteochondral tissue grafts with hierarchical structures Ivana Gadjanski, Gordana Vunjak Novakovic

PubMed Central

Gadjanski, Ivana; Vunjak-Novakovic, Gordana

2015-01-01

Introduction A major hurdle in treating osteochondral (OC) defects are the different healing abilities of two types of tissues involved - articular cartilage and subchondral bone. Biomimetic approaches to OC-construct-engineering, based on recapitulation of biological principles of tissue development and regeneration, have potential for providing new treatments and advancing fundamental studies of OC tissue repair. Areas covered This review on state of the art in hierarchical OC tissue graft engineering is focused on tissue engineering approaches designed to recapitulate the native milieu of cartilage and bone development. These biomimetic systems are discussed with relevance to bioreactor cultivation of clinically sized, anatomically shaped human cartilage/bone constructs with physiologic stratification and mechanical properties. The utility of engineered OC tissue constructs is evaluated for their use as grafts in regenerative medicine, and as high-fidelity models in biological research. Expert opinion A major challenge in engineering OC tissues is to generate a functionally integrated stratified cartilage-bone structure starting from one single population of mesenchymal cells, while incorporating perfusable vasculature into the bone, and in bone-cartilage interface. To this end, new generations of advanced scaffolds and bioreactors, implementation of mechanical loading regimens, and harnessing of inflammatory responses of the host will likely drive the further progress. PMID:26195329

Professional Ethics of Software Engineers: An Ethical Framework.

PubMed

Lurie, Yotam; Mark, Shlomo

2016-04-01

The purpose of this article is to propose an ethical framework for software engineers that connects software developers' ethical responsibilities directly to their professional standards. The implementation of such an ethical framework can overcome the traditional dichotomy between professional skills and ethical skills, which plagues the engineering professions, by proposing an approach to the fundamental tasks of the practitioner, i.e., software development, in which the professional standards are intrinsically connected to the ethical responsibilities. In so doing, the ethical framework improves the practitioner's professionalism and ethics. We call this approach Ethical-Driven Software Development (EDSD), as an approach to software development. EDSD manifests the advantages of an ethical framework as an alternative to the all too familiar approach in professional ethics that advocates "stand-alone codes of ethics". We believe that one outcome of this synergy between professional and ethical skills is simply better engineers. Moreover, since there are often different software solutions, which the engineer can provide to an issue at stake, the ethical framework provides a guiding principle, within the process of software development, that helps the engineer evaluate the advantages and disadvantages of different software solutions. It does not and cannot affect the end-product in and of-itself. However, it can and should, make the software engineer more conscious and aware of the ethical ramifications of certain engineering decisions within the process.

Introduction to multigrid methods

NASA Technical Reports Server (NTRS)

Wesseling, P.

1995-01-01

These notes were written for an introductory course on the application of multigrid methods to elliptic and hyperbolic partial differential equations for engineers, physicists and applied mathematicians. The use of more advanced mathematical tools, such as functional analysis, is avoided. The course is intended to be accessible to a wide audience of users of computational methods. We restrict ourselves to finite volume and finite difference discretization. The basic principles are given. Smoothing methods and Fourier smoothing analysis are reviewed. The fundamental multigrid algorithm is studied. The smoothing and coarse grid approximation properties are discussed. Multigrid schedules and structured programming of multigrid algorithms are treated. Robustness and efficiency are considered.

The Social Side of School: Why Teachers Need Social Psychology

ERIC Educational Resources Information Center

Gehlbach, Hunter

2010-01-01

Teaching and learning are fundamentally social enterprises. In attempting to understand, explain, and predict social behavior, social psychologists have amassed scores of empirically grounded, fundamental principles. Yet, many such principles have yet to be applied to classrooms despite the social nature of these settings. This article illustrates…

The Elements and Principles of Design: A Baseline Study

ERIC Educational Resources Information Center

Adams, Erin

2013-01-01

Critical to the discipline, both professionally and academically, are the fundamentals of interior design. These fundamentals include the elements and principles of interior design: the commonly accepted tools and vocabulary used to create and communicate successful interior environments. Research indicates a lack of consistency in both the…

3 CFR 13559 - Executive Order 13559 of November 17, 2010. Fundamental Principles and Policymaking Criteria for...

Code of Federal Regulations, 2011 CFR

2011-01-01

...; (vi) the Secretary of Housing and Urban Development; (vii) the Secretary of Education; (viii) the... social service programs or that support (including through prime awards or sub-awards) social service... following fundamental principles: (a) Federal financial assistance for social service programs should be...

Modernizing the Opposed-Piston Engine for More Efficient Military Ground Vehicle Applications

DTIC Science & Technology

2012-08-01

stroke (OP2S) engines and their use in military applications. It also highlights the engine’s fundamental architectural advantages. In addition, the...rejection. Furthermore, the paper includes an overview of the fundamental challenges of OP2S engines, along with a discussion of how Achates Power...It also highlights the engine’s fundamental architectural advantages. In addition, the paper introduces the Achates Power opposed-piston engine

Error-correction coding for digital communications

NASA Astrophysics Data System (ADS)

Clark, G. C., Jr.; Cain, J. B.

This book is written for the design engineer who must build the coding and decoding equipment and for the communication system engineer who must incorporate this equipment into a system. It is also suitable as a senior-level or first-year graduate text for an introductory one-semester course in coding theory. Fundamental concepts of coding are discussed along with group codes, taking into account basic principles, practical constraints, performance computations, coding bounds, generalized parity check codes, polynomial codes, and important classes of group codes. Other topics explored are related to simple nonalgebraic decoding techniques for group codes, soft decision decoding of block codes, algebraic techniques for multiple error correction, the convolutional code structure and Viterbi decoding, syndrome decoding techniques, and sequential decoding techniques. System applications are also considered, giving attention to concatenated codes, coding for the white Gaussian noise channel, interleaver structures for coded systems, and coding for burst noise channels.

Innovation, Novel Solutions and New Devices: The Engines that Drive the Magnetic Storage Industry; Choosing the Right Combination

NASA Astrophysics Data System (ADS)

Marinero, Ernesto E.

2011-03-01

Magnetic storage technology aims to achieve recording densities > 10 12 bits / in 2 intheforeseeablefuture . Thedimensionsofthemagneticdomainsandsensorminimumfeaturesizesatthisdensitywillbe ~ 15 -- 25 nm. These nanoscale dimensions present major challenges for both the materials utilized for magnetic recording, and to the sensors employed to reliably detect the minute magnetic fluxes emanating from such nanoscale domains. These include fundamental physical limits of material properties on account of the reduced dimensionality, as well as nanofabrication challenges to attain the required nanometer feature sizes with the stringent dimensional tolerances required. Since its invention in 1954, the storage density in magnetic recording has incremented by 109 and the cost of storage, measured in MB, has undergone a price reduction of the same order. Impressive as these accomplishments are, is the fact that the fundamental engineering principles of the technology today are essentially the same as when it was invented. This is in spite of numerous efforts to replace it with new alternative technologies or by dire predictions by its own practitioners of its impending death based on perceived limitations. In this talk the state-of-the art and challenges facing the HDD industry in its efforts to continue incrementing the storage density will be discussed. I will illustrate how advances in materials engineering, new physical phenomena and breakthroughs in nanofabrication have facilitated such an impressive technology evolution. Moreover, the key ingredients for said innovations to be implemented as technology solutions will be discussed..

A general transfer-function approach to noise filtering in open-loop quantum control

NASA Astrophysics Data System (ADS)

Viola, Lorenza

2015-03-01

Hamiltonian engineering via unitary open-loop quantum control provides a versatile and experimentally validated framework for manipulating a broad class of non-Markovian open quantum systems of interest, with applications ranging from dynamical decoupling and dynamically corrected quantum gates, to noise spectroscopy and quantum simulation. In this context, transfer-function techniques directly motivated by control engineering have proved invaluable for obtaining a transparent picture of the controlled dynamics in the frequency domain and for quantitatively analyzing performance. In this talk, I will show how to identify a computationally tractable set of ``fundamental filter functions,'' out of which arbitrary filter functions may be assembled up to arbitrary high order in principle. Besides avoiding the infinite recursive hierarchy of filter functions that arises in general control scenarios, this fundamental set suffices to characterize the error suppression capabilities of the control protocol in both the time and frequency domain. I will show, in particular, how the resulting notion of ``filtering order'' reveals conceptually distinct, albeit complementary, features of the controlled dynamics as compared to the ``cancellation order,'' traditionally defined in the Magnus sense. Implications for current quantum control experiments will be discussed. Work supported by the U.S. Army Research Office under Contract No. W911NF-14-1-0682.

Fundamentals of materials, techniques and instrumentation for OSL and FNTD dosimetry

NASA Astrophysics Data System (ADS)

Akselrod, M. S.

2013-02-01

The optically stimulated luminescence (OSL) technique has already become a successful commercial tool in personal radiation dosimetry, medical dosimetry, diagnostic imaging, geological and archeological dating. This review briefly describes the history and fundamental principles of OSL materials, methods and instrumentation. The advantages of OSL technology and instrumentation in comparison with thermoluminescent technique are analyzed. Progress in material and detector engineering has allowed new and promising developments regarding OSL applications in the medical field. Special attention is dedicated to Al2O3:C as a material of choice for many dosimetric applications including fiberoptic OSL/RL sensors with diameters as small as 300 μm. A new RL/OSL fiberoptic system has a high potential for in vivo and in vitro dosimetry in both radiation therapy and diagnostic mammography. Different aspects of instrumentation, data processing algorithms, post-irradiation and real-time measurements are described. The next technological breakthrough was done with Fluorescent Nuclear Track detectors (FNTD) that has some important advantages in measuring fast neutron and high energy heavy charge particles that became the latest tool in radiation therapy. New Mg-doped aluminum oxide crystals and novel type of imaging instrumentation for FNTD technology were engineered and successfully demonstrated for occupational and accident dosimetry, for medical dosimetry and radiobiological research.

AUTOMOTIVE DIESEL MAINTENANCE 1. UNIT XVIII, I--UNDERSTAND ENGINE GEARS AND GEARING PRINCIPLES, II--MACK INTER-AXLE POWER DIVIDER.

ERIC Educational Resources Information Center

Minnesota State Dept. of Education, St. Paul. Div. of Vocational and Technical Education.

THIS MODULE OF A 30-MODULE COURSE IS DESIGNED TO DEVELOP AN UNDERSTANDING OF DIESEL ENGINE GEARS AND GEARING PRINCIPLES AND THE OPERATING PRINCIPLES AND MAINTENANCE OF POWER DIVIDERS (GEAR BOXES) USED IN DIESEL ENGINE POWER TRANSMISSION. TOPICS ARE (1) THE PURPOSE OF THE ENGINE GEARS, (2) INSPECTING FOR GEAR FAILURES, (3) INSPECTING FOR SHAFT…

Inclusive Education: An EFA Strategy For All Children 31195

ERIC Educational Resources Information Center

Peters, Susan J.

2004-01-01

The fundamental principle of Education for All (EFA) is that all children should have the opportunity to learn. The fundamental principle of Inclusive Education (IE) is that all children should have the opportunity to learn?together. Diversity is a characteristic that all children and youth have in common?both within each individual child and…

Regenerative medicine primer.

PubMed

Terzic, Andre; Nelson, Timothy J

2013-07-01

The pandemic of chronic diseases, compounded by the scarcity of usable donor organs, mandates radical innovation to address the growing unmet needs of individuals and populations. Beyond life-extending measures that are often the last available option, regenerative strategies offer transformative solutions in treating degenerative conditions. By leveraging newfound knowledge of the intimate processes fundamental to organogenesis and healing, the emerging regenerative armamentarium aims to boost the aptitude of human tissues for self-renewal. Regenerative technologies strive to promote, augment, and reestablish native repair processes, restituting organ structure and function. Multimodal regenerative approaches incorporate transplant of healthy tissues into damaged environments, prompt the body to enact a regenerative response in damaged tissues, and use tissue engineering to manufacture new tissue. Stem cells and their products have a unique aptitude to form specialized tissues and promote repair signaling, providing active ingredients of regenerative regimens. Concomitantly, advances in materials science and biotechnology have unlocked additional prospects for growing tissue grafts and engineering organs. Translation of regenerative principles into practice is feasible and safe in the clinical setting. Regenerative medicine and surgery are, thus, poised to transit from proof-of-principle studies toward clinical validation and, ultimately, standardization, paving the way for next-generation individualized management algorithms. Copyright © 2013 Mayo Foundation for Medical Education and Research. Published by Elsevier Inc. All rights reserved.

Cutting Off the Head of the Snake: Applying and Assessing Leadership Attack in Military Conflict

DTIC Science & Technology

2013-04-26

war that will help 13 17 Baron Antoine Henri de Jomini makes this argument when he describes what he calls the Fundamental Principle of War: “On the... of Napoleonic Warfare, Clausewitz had but a vague understanding of it. Nevertheless, because of Napoleon’s offensive principle , he foisted on to... of the Enemy is the Aim,” Clausewitz opens the chapter by weaving the idea of Schwerpunkt into his two fundamental principles of war: The first is

Design and integration of a problem-based biofabrication course into an undergraduate biomedical engineering curriculum.

PubMed

Raman, Ritu; Mitchell, Marlon; Perez-Pinera, Pablo; Bashir, Rashid; DeStefano, Lizanne

2016-01-01

The rapidly evolving discipline of biological and biomedical engineering requires adaptive instructional approaches that teach students to target and solve multi-pronged and ill-structured problems at the cutting edge of scientific research. Here we present a modular approach to designing a lab-based course in the emerging field of biofabrication and biological design, leading to a final capstone design project that requires students to formulate and test a hypothesis using the scientific method. Students were assessed on a range of metrics designed to evaluate the format of the course, the efficacy of the format for teaching new topics and concepts, and the depth of the contribution this course made to students training for biological engineering careers. The evaluation showed that the problem-based format of the course was well suited to teaching students how to use the scientific method to investigate and uncover the fundamental biological design rules that govern the field of biofabrication. We show that this approach is an efficient and effective method of translating emergent scientific principles from the lab bench to the classroom and training the next generation of biological and biomedical engineers for careers as researchers and industry practicians.

Genetic engineering: a matter that requires further refinement in Spanish secondary school textbooks

NASA Astrophysics Data System (ADS)

Martínez-Gracia, M. V.; Gil-Quýlez, M. J.

2003-09-01

Genetic engineering is now an integral part of many high school textbooks but little work has been done to assess whether it is being properly addressed. A checklist with 19 items was used to analyze how genetic engineering is presented in biology textbooks commonly used in Spanish high schools, including the content, its relationship with fundamental genetic principles, and how it aims to improve the genetic literacy of students. The results show that genetic engineering was normally introduced without a clear reference to the universal genetic code, protein expression or the genetic material shared by all species. In most cases it was poorly defined, without a clear explanation of all the relevant processes involved. Some procedures (such as vectors) were explained in detail without considering previous student knowledge or skills. Some books emphasized applications such as the human genome project without describing DNA sequencing. All books included possible repercussions, but in most cases only fashionable topics such as human cloning. There was an excess of information that was not always well founded and hence was unsuitable to provide a meaningful understanding of DNA technology required for citizens in the twenty-first century.

Is the 2nd Law of Thermodynamics Conditioned? Separating Heat and Cold by a Magnetic Body Force and the Principle for a Non-Carnot Engine

NASA Astrophysics Data System (ADS)

Luo, Weili

2017-11-01

A new type of heat engine has been proposed in 2005 that defies fundamental thermodynamic law: A specifically designed magnetic body force can reverse heat flow from high temperature to low temperature. This mechanism can drive heat to higher temperature, rendering the possibility to re-use the ``waste heat''. As the result, the efficiency is much higher than that of the Carnot Engine. In a recent paper a realization of this proposed mechanism is reported: by using a specific configuration of temperature and magnetic field gradients, we observed that magnetic body force suppresses the gravito-thermal convective heat when the gradients of temperature and field are anti-parallel to each other. This driving force stops the heat flow of approaching to thermal equilibrium in the system, causing the temperature difference across the sample to increase with applied fields. In this work, I will discuss the driving mechanism for this phenomenon and its application in the proposed engine. This remarkable result suggests that the 2nd law of thermodynamics maybe conditioned and needs to be re-examined.

The Fundamental Nature of Engineering Education in Russia and Belarus: A Challenge to Technological Development

ERIC Educational Resources Information Center

Kotlyarov, I. V.; Kostyukevich, S. V.; Yakovleva, N. I.

2015-01-01

In this article we investigate the problem of the balance of fundamental and applied training in technical colleges through the lens of a historical analysis of the development of the Soviet school of engineering. We demonstrate that the Soviet school of engineering became overreliant on fundamental education due to historical features of its…

Green engineering education through a U.S. EPA/academia collaboration.

PubMed

Shonnard, David R; Allen, David T; Nguyen, Nhan; Austin, Sharon Weil; Hesketh, Robert

2003-12-01

The need to use resources efficiently and reduce environmental impacts of industrial products and processes is becoming increasingly important in engineering design; therefore, green engineering principles are gaining prominence within engineering education. This paper describes a general framework for incorporating green engineering design principles into engineering curricula, with specific examples for chemical engineering. The framework for teaching green engineering discussed in this paper mirrors the 12 Principles of Green Engineering proposed by Anastas and Zimmerman (Environ. Sci. Technol. 2003, 37, 94A-101A), especially in methods for estimating the hazardous nature of chemicals, strategies for pollution prevention, and approaches leading to efficient energy and material utilization. The key elements in green engineering education, which enlarge the "box" for engineering design, are environmental literacy, environmentally conscious design, and beyond-the-plant boundary considerations.

Reflexive Principlism as an Effective Approach for Developing Ethical Reasoning in Engineering.

PubMed

Beever, Jonathan; Brightman, Andrew O

2016-02-01

An important goal of teaching ethics to engineering students is to enhance their ability to make well-reasoned ethical decisions in their engineering practice: a goal in line with the stated ethical codes of professional engineering organizations. While engineering educators have explored a wide range of methodologies for teaching ethics, a satisfying model for developing ethical reasoning skills has not been adopted broadly. In this paper we argue that a principlist-based approach to ethical reasoning is uniquely suited to engineering ethics education. Reflexive Principlism is an approach to ethical decision-making that focuses on internalizing a reflective and iterative process of specification, balancing, and justification of four core ethical principles in the context of specific cases. In engineering, that approach provides structure to ethical reasoning while allowing the flexibility for adaptation to varying contexts through specification. Reflexive Principlism integrates well with the prevalent and familiar methodologies of reasoning within the engineering disciplines as well as with the goals of engineering ethics education.

Fundamental Principles of Coherent-Feedback Quantum Control

DTIC Science & Technology

2014-12-08

in metrology (acceleration sensing, vibrometry, gravity wave detection) and in quantum information processing (continuous-variables quantum ...AFRL-OSR-VA-TR-2015-0009 FUNDAMENTAL PRINCIPLES OF COHERENT-FEEDBACK QUANTUM CONTROL Hideo Mabuchi LELAND STANFORD JUNIOR UNIV CA Final Report 12/08...foundations and potential applications of coherent-feedback quantum control. We have focused on potential applications in quantum -enhanced metrology and

Research on numerical simulation and protection of transient process in long-distance slurry transportation pipelines

NASA Astrophysics Data System (ADS)

Lan, G.; Jiang, J.; Li, D. D.; Yi, W. S.; Zhao, Z.; Nie, L. N.

2013-12-01

The calculation of water-hammer pressure phenomenon of single-phase liquid is already more mature for a pipeline of uniform characteristics, but less research has addressed the calculation of slurry water hammer pressure in complex pipelines with slurry flows carrying solid particles. In this paper, based on the developments of slurry pipelines at home and abroad, the fundamental principle and method of numerical simulation of transient processes are presented, and several boundary conditions are given. Through the numerical simulation and analysis of transient processes of a practical engineering of long-distance slurry transportation pipeline system, effective protection measures and operating suggestions are presented. A model for calculating the water impact of solid and fluid phases is established based on a practical engineering of long-distance slurry pipeline transportation system. After performing a numerical simulation of the transient process, analyzing and comparing the results, effective protection measures and operating advice are recommended, which has guiding significance to the design and operating management of practical engineering of longdistance slurry pipeline transportation system.

Elementary Concepts and Fundamental Laws of the Theory of Heat

NASA Astrophysics Data System (ADS)

de Oliveira, Mário J.

2018-06-01

The elementary concepts and fundamental laws concerning the science of heat are examined from the point of view of its development with special attention to its theoretical structure. The development is divided into four periods, each one characterized by the concept that was attributed to heat. The transition from one to the next period was marked by the emergence of new concepts and new laws, and by singular events. We point out that thermodynamics, as it emerged, is founded on the elementary concepts of temperature and adiabatic wall, and on the fundamental laws: Mayer-Joule principle, or law of conservation of energy; Carnot principle, which leads to the definition of entropy; and the Clausius principle, or law of increase in entropy.

Elementary Concepts and Fundamental Laws of the Theory of Heat

NASA Astrophysics Data System (ADS)

de Oliveira, Mário J.

2018-03-01

The elementary concepts and fundamental laws concerning the science of heat are examined from the point of view of its development with special attention to its theoretical structure. The development is divided into four periods, each one characterized by the concept that was attributed to heat. The transition from one to the next period was marked by the emergence of new concepts and new laws, and by singular events. We point out that thermodynamics, as it emerged, is founded on the elementary concepts of temperature and adiabatic wall, and on the fundamental laws: Mayer-Joule principle, or law of conservation of energy; Carnot principle, which leads to the definition of entropy; and the Clausius principle, or law of increase in entropy.

Physics architecture

NASA Astrophysics Data System (ADS)

Konopleva, Nelly

2017-03-01

Fundamental physical theory axiomatics is closely connected with methods of experimental measurements. The difference between the theories using global and local symmetries is explained. It is shown that symmetry group localization leads not only to the change of the relativity principle, but to the fundamental modification of experimental programs testing physical theory predictions. It is noticed that any fundamental physical theory must be consistent with the measurement procedures employed for its testing. These ideas are illustrated by events of my biography connected with Yang-Mills theory transformation from an ordinary phenomenological model to a fundamental physical theory based on local symmetry principles like the Einsteinian General Relativity. Baldin position in this situation is demonstrated.

Many-Worlds Interpretation of Quantum Theory and Mesoscopic Anthropic Principle

NASA Astrophysics Data System (ADS)

Kamenshchik, A. Yu.; Teryaev, O. V.

2008-10-01

We suggest to combine the Anthropic Principle with Many-Worlds Interpretation of Quantum Theory. Realizing the multiplicity of worlds it provides an opportunity of explanation of some important events which are assumed to be extremely improbable. The Mesoscopic Anthropic Principle suggested here is aimed to explain appearance of such events which are necessary for emergence of Life and Mind. It is complementary to Cosmological Anthropic Principle explaining the fine tuning of fundamental constants. We briefly discuss various possible applications of Mesoscopic Anthropic Principle including the Solar Eclipses and assembling of complex molecules. Besides, we address the problem of Time's Arrow in the framework of Many-World Interpretation. We suggest the recipe for disentangling of quantities defined by fundamental physical laws and by an anthropic selection.

Software-engineering challenges of building and deploying reusable problem solvers.

PubMed

O'Connor, Martin J; Nyulas, Csongor; Tu, Samson; Buckeridge, David L; Okhmatovskaia, Anna; Musen, Mark A

2009-11-01

Problem solving methods (PSMs) are software components that represent and encode reusable algorithms. They can be combined with representations of domain knowledge to produce intelligent application systems. A goal of research on PSMs is to provide principled methods and tools for composing and reusing algorithms in knowledge-based systems. The ultimate objective is to produce libraries of methods that can be easily adapted for use in these systems. Despite the intuitive appeal of PSMs as conceptual building blocks, in practice, these goals are largely unmet. There are no widely available tools for building applications using PSMs and no public libraries of PSMs available for reuse. This paper analyzes some of the reasons for the lack of widespread adoptions of PSM techniques and illustrate our analysis by describing our experiences developing a complex, high-throughput software system based on PSM principles. We conclude that many fundamental principles in PSM research are useful for building knowledge-based systems. In particular, the task-method decomposition process, which provides a means for structuring knowledge-based tasks, is a powerful abstraction for building systems of analytic methods. However, despite the power of PSMs in the conceptual modeling of knowledge-based systems, software engineering challenges have been seriously underestimated. The complexity of integrating control knowledge modeled by developers using PSMs with the domain knowledge that they model using ontologies creates a barrier to widespread use of PSM-based systems. Nevertheless, the surge of recent interest in ontologies has led to the production of comprehensive domain ontologies and of robust ontology-authoring tools. These developments present new opportunities to leverage the PSM approach.

Software-engineering challenges of building and deploying reusable problem solvers

PubMed Central

O’CONNOR, MARTIN J.; NYULAS, CSONGOR; TU, SAMSON; BUCKERIDGE, DAVID L.; OKHMATOVSKAIA, ANNA; MUSEN, MARK A.

2012-01-01

Problem solving methods (PSMs) are software components that represent and encode reusable algorithms. They can be combined with representations of domain knowledge to produce intelligent application systems. A goal of research on PSMs is to provide principled methods and tools for composing and reusing algorithms in knowledge-based systems. The ultimate objective is to produce libraries of methods that can be easily adapted for use in these systems. Despite the intuitive appeal of PSMs as conceptual building blocks, in practice, these goals are largely unmet. There are no widely available tools for building applications using PSMs and no public libraries of PSMs available for reuse. This paper analyzes some of the reasons for the lack of widespread adoptions of PSM techniques and illustrate our analysis by describing our experiences developing a complex, high-throughput software system based on PSM principles. We conclude that many fundamental principles in PSM research are useful for building knowledge-based systems. In particular, the task–method decomposition process, which provides a means for structuring knowledge-based tasks, is a powerful abstraction for building systems of analytic methods. However, despite the power of PSMs in the conceptual modeling of knowledge-based systems, software engineering challenges have been seriously underestimated. The complexity of integrating control knowledge modeled by developers using PSMs with the domain knowledge that they model using ontologies creates a barrier to widespread use of PSM-based systems. Nevertheless, the surge of recent interest in ontologies has led to the production of comprehensive domain ontologies and of robust ontology-authoring tools. These developments present new opportunities to leverage the PSM approach. PMID:23565031

First-principles study of band gap engineering via oxygen vacancy doping in perovskite ABB'O₃ solid solutions

DOE PAGES

Qi, Tingting; Curnan, Matthew T.; Kim, Seungchul; ...

2011-12-15

Oxygen vacancies in perovskite oxide solid solutions are fundamentally interesting and technologically important. However, experimental characterization of the vacancy locations and their impact on electronic structure is challenging. We have carried out first-principles calculations on two Zr-modified solid solutions, Pb(Zn 1/3Nb 2/3)O₃ and Pb(Mg 1/3Nb 2/3)O₃, in which vacancies are present. We find that the vacancies are more likely to reside between low-valent cation-cation pairs than high-valent cation-cation pairs. Based on the analysis of our results, we formulate guidelines that can be used to predict the location of oxygen vacancies in perovskite solid solutions. Our results show that vacancies canmore » have a significant impact on both the conduction and valence band energies, in some cases lowering the band gap by ≈0.5 eV. The effects of vacancies on the electronic band structure can be understood within the framework of crystal field theory.« less

DNA Charge Transport: From Chemical Principles to the Cell

PubMed Central

Arnold, Anna R.; Grodick, Michael A.; Barton, Jacqueline K.

2016-01-01

The DNA double helix has captured the imagination of many, bringing it to the forefront of biological research. DNA has unique features that extend our interest into areas of chemistry, physics, material science and engineering. Our laboratory has focused on studies of DNA charge transport (CT), wherein charges can efficiently travel long molecular distances through the DNA helix while maintaining an exquisite sensitivity to base pair π-stacking. Because DNA CT chemistry reports on the integrity of the DNA duplex, this property may be exploited to develop electrochemical devices to detect DNA lesions and DNA-binding proteins. Furthermore, studies now indicate that DNA CT may also be used in the cell by, for example, DNA repair proteins, as a cellular diagnostic, in order to scan the genome to localize efficiently to damage sites. In this review, we describe this evolution of DNA CT chemistry from the discovery of fundamental chemical principles to applications in diagnostic strategies and possible roles in biology. PMID:26933744

Molecular Theory of Detonation Initiation: Insight from First Principles Modeling of the Decomposition Mechanisms of Organic Nitro Energetic Materials.

PubMed

Tsyshevsky, Roman V; Sharia, Onise; Kuklja, Maija M

2016-02-19

This review presents a concept, which assumes that thermal decomposition processes play a major role in defining the sensitivity of organic energetic materials to detonation initiation. As a science and engineering community we are still far away from having a comprehensive molecular detonation initiation theory in a widely agreed upon form. However, recent advances in experimental and theoretical methods allow for a constructive and rigorous approach to design and test the theory or at least some of its fundamental building blocks. In this review, we analyzed a set of select experimental and theoretical articles, which were augmented by our own first principles modeling and simulations, to reveal new trends in energetic materials and to refine known existing correlations between their structures, properties, and functions. Our consideration is intentionally limited to the processes of thermally stimulated chemical reactions at the earliest stage of decomposition of molecules and materials containing defects.

Molecular Theory of Detonation Initiation: Insight from First Principles Modeling of the Decomposition Mechanisms of Organic Nitro Energetic Materials

DOE PAGES

Tsyshevsky, Roman; Sharia, Onise; Kuklja, Maija

2016-02-19

Our review presents a concept, which assumes that thermal decomposition processes play a major role in defining the sensitivity of organic energetic materials to detonation initiation. As a science and engineering community we are still far away from having a comprehensive molecular detonation initiation theory in a widely agreed upon form. However, recent advances in experimental and theoretical methods allow for a constructive and rigorous approach to design and test the theory or at least some of its fundamental building blocks. In this review, we analyzed a set of select experimental and theoretical articles, which were augmented by our ownmore » first principles modeling and simulations, to reveal new trends in energetic materials and to refine known existing correlations between their structures, properties, and functions. Lastly, our consideration is intentionally limited to the processes of thermally stimulated chemical reactions at the earliest stage of decomposition of molecules and materials containing defects.« less

Experimental demonstration of information to energy conversion in a quantum system at the Landauer limit.

PubMed

Peterson, J P S; Sarthour, R S; Souza, A M; Oliveira, I S; Goold, J; Modi, K; Soares-Pinto, D O; Céleri, L C

2016-04-01

Landauer's principle sets fundamental thermodynamical constraints for classical and quantum information processing, thus affecting not only various branches of physics, but also of computer science and engineering. Despite its importance, this principle was only recently experimentally considered for classical systems. Here we employ a nuclear magnetic resonance set-up to experimentally address the information to energy conversion in a quantum system. Specifically, we consider a three nuclear spins [Formula: see text] (qubits) molecule-the system, the reservoir and the ancilla-to measure the heat dissipated during the implementation of a global system-reservoir unitary interaction that changes the information content of the system. By employing an interferometric technique, we were able to reconstruct the heat distribution associated with the unitary interaction. Then, through quantum state tomography, we measured the relative change in the entropy of the system. In this way, we were able to verify that an operation that changes the information content of the system must necessarily generate heat in the reservoir, exactly as predicted by Landauer's principle. The scheme presented here allows for the detailed study of irreversible entropy production in quantum information processors.

Principles of Sociology in Systems Engineering

NASA Technical Reports Server (NTRS)

Watson, Michael D.; Andrews, James G.; Larsen, Jordan A.

2017-01-01

Systems engineering involves both the integration of the system and the integration of the disciplines which develop and operate the system. Integrating the disciplines is a sociological effort to bring together different groups, often with different terminology, to achieve a common goal, the system. The focus for the systems engineer is information flow through the organization, between the disciplines, to ensure the system is developed and operated with all relevant information informing system decisions. Robert K. Merton studied the sociological principles of the sciences and the sociological principles he developed apply to systems engineering. Concepts such as specification of ignorance, common terminology, opportunity structures, role-sets, and the reclama (reconsideration) process are all important sociological approaches that should be employed by the systems engineer. In bringing the disciplines together, the systems engineer must also be wary of social ambivalence, social anomie, social dysfunction, insider-outsider behavior, unintended consequences, and the self-fulfilling prophecy. These sociological principles provide the systems engineer with key approaches to manage the information flow through the organization as the disciplines are integrated and share their information. This also helps identify key sociological barriers to information flow through the organization. This paper will discuss this theoretical basis for the application of sociological principles to systems engineering.

How You Store Information Affects How You Can Retrieve It: A Fundamental Principle for Business Students Studying Information Systems and Technology

ERIC Educational Resources Information Center

Silver, Mark S.

2017-01-01

During the current period of rapid technological change, business students need to emerge from their introductory course in Information Systems (IS) with a set of fundamental principles to help them "think about Information Technology (IT)" in future courses and the workplace. Given the digital revolution, they also need to appreciate…

Dielectric properties of agricultural products – fundamental principles, influencing factors, and measurement technirques. Chapter 4. Electrotechnologies for Food Processing: Book Series. Volume 3. Radio-Frequency Heating

USDA-ARS?s Scientific Manuscript database

In this chapter, definitions of dielectric properties, or permittivity, of materials and a brief discussion of the fundamental principles governing their behavior with respect to influencing factors are presented. The basic physics of the influence of frequency of the electric fields and temperatur...

``From Fundamental Motives to Rational Expectation Equilibrium[REE, henceworth] of Indeterminacy''

NASA Astrophysics Data System (ADS)

Maksoed, Ssi, Wh-

For ``Principle of Indeterminacy''from Heisenberg states: ``one of the fundamental cornerstone of quantum mechanics is the Heisenberg uncertainty principle''.whereas canonically conjugate quantities can be determined simultaneously only with a characteristic indeterminacy[M. Arevalo Aguilar, et.al]. Accompanying Alfred North Whitehead conclusion in ``The Aims of Education''that mathematical symbols are artificial before new meanings given, two kinds of fundamental motives: (i) expectation-expectation, (ii) expectation-certainty inherently occurs with determinacy properties of rational expectation equilibrium(REE, henceworth)- Guido Ascari & Tizano Ropele:''Trend inflation, Taylor principle & Indeterminacy'', Kiel Institute, June 2007. Furthers, relative price expression can be compare of their α and (1 - α) configurations in the expression of possible activity. Acknowledgment to Prof[asc]. Dr. Bobby Eka Gunara for ``made a rank through physics'' denotes...

Designing for Success: Developing Engineers Who Consider Universal Design Principles

ERIC Educational Resources Information Center

Bigelow, Kimberly Edginton

2012-01-01

Engineers must design for a diverse group of potential users of their products; however, engineering curricula rarely include an emphasis on universal design principles. This research article details the effectiveness of a design project implemented in a first-year engineering course in an effort to raise awareness of the need for engineers to be…

Tissue Engineering Approaches in the Design of Healthy and Pathological In Vitro Tissue Models

PubMed Central

Caddeo, Silvia; Boffito, Monica; Sartori, Susanna

2017-01-01

In the tissue engineering (TE) paradigm, engineering and life sciences tools are combined to develop bioartificial substitutes for organs and tissues, which can in turn be applied in regenerative medicine, pharmaceutical, diagnostic, and basic research to elucidate fundamental aspects of cell functions in vivo or to identify mechanisms involved in aging processes and disease onset and progression. The complex three-dimensional (3D) microenvironment in which cells are organized in vivo allows the interaction between different cell types and between cells and the extracellular matrix, the composition of which varies as a function of the tissue, the degree of maturation, and health conditions. In this context, 3D in vitro models can more realistically reproduce a tissue or organ than two-dimensional (2D) models. Moreover, they can overcome the limitations of animal models and reduce the need for in vivo tests, according to the “3Rs” guiding principles for a more ethical research. The design of 3D engineered tissue models is currently in its development stage, showing high potential in overcoming the limitations of already available models. However, many issues are still opened, concerning the identification of the optimal scaffold-forming materials, cell source and biofabrication technology, and the best cell culture conditions (biochemical and physical cues) to finely replicate the native tissue and the surrounding environment. In the near future, 3D tissue-engineered models are expected to become useful tools in the preliminary testing and screening of drugs and therapies and in the investigation of the molecular mechanisms underpinning disease onset and progression. In this review, the application of TE principles to the design of in vitro 3D models will be surveyed, with a focus on the strengths and weaknesses of this emerging approach. In addition, a brief overview on the development of in vitro models of healthy and pathological bone, heart, pancreas, and liver will be presented. PMID:28798911

Tissue Engineering Approaches in the Design of Healthy and Pathological In Vitro Tissue Models.

PubMed

Caddeo, Silvia; Boffito, Monica; Sartori, Susanna

2017-01-01

In the tissue engineering (TE) paradigm, engineering and life sciences tools are combined to develop bioartificial substitutes for organs and tissues, which can in turn be applied in regenerative medicine, pharmaceutical, diagnostic, and basic research to elucidate fundamental aspects of cell functions in vivo or to identify mechanisms involved in aging processes and disease onset and progression. The complex three-dimensional (3D) microenvironment in which cells are organized in vivo allows the interaction between different cell types and between cells and the extracellular matrix, the composition of which varies as a function of the tissue, the degree of maturation, and health conditions. In this context, 3D in vitro models can more realistically reproduce a tissue or organ than two-dimensional (2D) models. Moreover, they can overcome the limitations of animal models and reduce the need for in vivo tests, according to the "3Rs" guiding principles for a more ethical research. The design of 3D engineered tissue models is currently in its development stage, showing high potential in overcoming the limitations of already available models. However, many issues are still opened, concerning the identification of the optimal scaffold-forming materials, cell source and biofabrication technology, and the best cell culture conditions (biochemical and physical cues) to finely replicate the native tissue and the surrounding environment. In the near future, 3D tissue-engineered models are expected to become useful tools in the preliminary testing and screening of drugs and therapies and in the investigation of the molecular mechanisms underpinning disease onset and progression. In this review, the application of TE principles to the design of in vitro 3D models will be surveyed, with a focus on the strengths and weaknesses of this emerging approach. In addition, a brief overview on the development of in vitro models of healthy and pathological bone, heart, pancreas, and liver will be presented.

The Application of Tissue Engineering Procedures to Repair the Larynx

ERIC Educational Resources Information Center

Ringel, Robert L.; Kahane, Joel C.; Hillsamer, Peter J.; Lee, Annie S.; Badylak, Stephen F.

2006-01-01

The field of tissue engineering/regenerative medicine combines the quantitative principles of engineering with the principles of the life sciences toward the goal of reconstituting structurally and functionally normal tissues and organs. There has been relatively little application of tissue engineering efforts toward the organs of speech, voice,…

Fundamental Assumptions and Aims Underlying the Principles and Policies of Federal Financial Aid to Students. Research Report.

ERIC Educational Resources Information Center

Johnstone, D. Bruce

As background to the National Dialogue on Student Financial Aid, this essay discusses the fundamental assumptions and aims that underlie the principles and policies of federal financial aid to students. These eight assumptions and aims are explored: (1) higher education is the province of states, and not of the federal government; (2) the costs of…

Complementary Huygens Principle for Geometrical and Nongeometrical Optics

ERIC Educational Resources Information Center

Luis, Alfredo

2007-01-01

We develop a fundamental principle depicting the generalized ray formulation of optics provided by the Wigner function. This principle is formally identical to the Huygens-Fresnel principle but in terms of opposite concepts, rays instead of waves, and incoherent superpositions instead of coherent ones. This ray picture naturally includes…

23 CFR 627.5 - General principles and procedures.

Code of Federal Regulations, 2012 CFR

2012-04-01

... Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ENGINEERING AND TRAFFIC OPERATIONS VALUE ENGINEERING § 627.5 General principles and procedures. (a) State VE programs. State transportation... studies. (2) Studies. Value engineering studies shall follow the widely recognized systematic problem...

23 CFR 627.5 - General principles and procedures.

Code of Federal Regulations, 2011 CFR

2011-04-01

... Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ENGINEERING AND TRAFFIC OPERATIONS VALUE ENGINEERING § 627.5 General principles and procedures. (a) State VE programs. State transportation... studies. (2) Studies. Value engineering studies shall follow the widely recognized systematic problem...

23 CFR 627.5 - General principles and procedures.

Code of Federal Regulations, 2010 CFR

2010-04-01

... Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ENGINEERING AND TRAFFIC OPERATIONS VALUE ENGINEERING § 627.5 General principles and procedures. (a) State VE programs. State transportation... studies. (2) Studies. Value engineering studies shall follow the widely recognized systematic problem...

The Peculiar Status of the Second Law of Thermodynamics and the Quest for its Violation

NASA Astrophysics Data System (ADS)

D'Abramo, Germano

2012-11-01

Even though the second law of thermodynamics holds the supreme position among the laws of nature, as stated by many distinguished scientists, notably Eddington and Einstein, its position appears to be also quite peculiar. Given the atomic nature of matter, whose behaviour is well described by statistical physics, the second law could not hold unconditionally, but only statistically. It is not an absolute law. As a result of this, in the present paper we try to argue that we have not yet any truly cogent argument (known fundamental physical laws) to exclude its possible macroscopic violation. Even Landauer's information-theoretic principle seems to fall short of the initial expectations of being the fundamental `physical' reason of all Maxwell's demons failure. Here we propose a modified Szilard engine which operates without any steps in the process resembling the creation or destruction of information. We argue that the information-based exorcisms must be wrong, or at the very least superfluous, and that the real physical reason why such engines cannot work lies in the ubiquity of thermal fluctuations (and friction). We see in the above peculiar features the main motivation and rationale for pursuing exploratory research to challenge the second law, which is still ongoing and probably richer than ever. A quite thorough (and critical) description of some of these challenges is also given.

The peculiar status of the second law of thermodynamics and the quest for its violation

NASA Astrophysics Data System (ADS)

D'Abramo, Germano

2012-11-01

Even though the second law of thermodynamics holds the supreme position among the laws of nature, as stated by many distinguished scientists, notably Eddington and Einstein, its position appears to be also quite peculiar. Given the atomic nature of matter, whose behavior is well described by statistical physics, the second law could not hold unconditionally, but only statistically. It is not an absolute law. As a result of this, in the present paper we try to argue that we have not yet any truly cogent argument (known fundamental physical laws) to exclude its possible macroscopic violation. Even Landauer's information-theoretic principle seems to fall short of the initial expectations of being the fundamental 'physical' reason of all Maxwell's demons failure. Here we propose a modified Szilard engine which operates without any steps in the process resembling the creation or destruction of information. We argue that the information-based exorcisms must be wrong, or at the very least superfluous, and that the real physical reason why such engines cannot work lies in the ubiquity of thermal fluctuations (and friction). We see in the above peculiar features the main motivation and rationale for pursuing exploratory research to challenge the second law, which is still ongoing and probably richer than ever. A quite thorough (and critical) description of some of these challenges is also given.

Thick thermal barrier coatings for diesel engines

NASA Technical Reports Server (NTRS)

Beardsley, M. Brad

1995-01-01

Caterpillar's approach to applying thick thermal barrier coatings (TTBC's) to diesel engine combustion chambers has been to use advanced modeling techniques to predict engine conditions and combine this information with fundamental property evaluation of TTBC systems to predict engine performance and TTBC stress states. Engine testing has been used to verify the predicted performance of the TTBC systems and provide information on failure mechanisms. The objective Caterpillar's program to date has been to advance the fundamental understanding of thick thermal barrier coating systems. Previous reviews of thermal barrier coating technology concluded that the current level of understanding of coating system behavior is inadequate and the lack of fundamental understanding may impeded the application of TTBC's to diesel engines. Areas of TTBC technology being examined in this program include powder characteristics and chemistry; bond coat composition; coating design, microstructure, and thickness as they affect properties, durability, and reliability; and TTBC 'aging' effects (microstructural and property changes) under diesel engine operating conditions. Methods to evaluate the reliability and durability of TTBC's have been developed that attempt to understand the fundamental strength of TTBC's for particular stress states.

Thick thermal barrier coatings for diesel engines

NASA Technical Reports Server (NTRS)

Beardsley, M. B.

1995-01-01

Caterpillar's approach to applying Thick Thermal Barrier Coatings (TTBC's) to diesel engine combustion chambers has been to use advanced modeling techniques to predict engine conditions and combine this information with fundamental property evaluation of TTBC systems to predict engine performance and TTBC stress states. Engine testing has been used to verify the predicted performance of the TTBC systems and provide information on failure mechanisms. The objective of Caterpillar's subcontract with ORNL is to advance the fundamental understanding of thick thermal barrier coating systems. Previous reviews of thermal barrier coating technology concluded that the current level of understanding of coating system behavior is inadequate and the lack of fundamental understanding may impede the application of TTBC's to diesel engines. Areas of TTBC technology being examined in this program include powder characteristics and chemistry; bond coat composition; coating design, microstructure, and thickness as they affect properties, durability, and reliability; and TTBC 'aging' effects (microstructural and property changes) under diesel engine operating conditions. Methods to evaluate the reliability and durability of TTBC's have been developed that attempt to understand the fundamental strength of TTBC's for particular stress states.

Green Engineering Principle #4 Maximize Efficiency

EPA Science Inventory

As one reads the twelve principles of Green Engineering, there is one message that stands out and becomes ever increasingly more evident with each principle. Moreover, that message is simplicity! It is simplicity that will allow us, as a society, to become more sustainable.Althou...

Modern Aspects of Liquid Metal Engineering

NASA Astrophysics Data System (ADS)

Czerwinski, Frank

2017-02-01

Liquid metal engineering (LME) refers to a variety of physical and/or chemical treatments of molten metals aimed at influencing their solidification characteristics. Although the fundamentals have been known for decades, only recent progress in understanding solidification mechanisms has renewed an interest in opportunities this technique creates for an improvement of castings. This review covers conventional and novel concepts of LME with their application to modern manufacturing techniques based not only on liquid but also on semisolid routes. The role of external forces applied to the melt combined with grain nucleation control is explained along with laboratory- and commercial-scale equipment designed for implementation of various concepts exploring mechanical, electromagnetic, and ultrasound principles. An influence of melt treatments on quality of the final product is considered through distinguishing between internal integrity of net shape components and the alloy microstructure. Recent global developments indicate that exploring the synergy of melt chemistry and physical treatments achieved through LME allows creating the optimum conditions for nucleation and growth during solidification, positively affecting quality of castings.

Detection principle of gravitational wave detectors

NASA Astrophysics Data System (ADS)

Congedo, Giuseppe

With the first two detections in late 2015, astrophysics has officially entered into the new era of gravitational wave (GW) observations. Since then, much has been going on in the field with a lot of work focusing on the observations and implications for astrophysics and tests of general relativity in the strong regime. However, much less is understood about how gravitational detectors really work at their fundamental level. For decades, the response to incoming signals has been customarily calculated using the very same physical principle, which has proved so successful in the first detections. In this paper, we review the physical principle that is behind such a detection at the very fundamental level, and we try to highlight the peculiar subtleties that make it so hard in practice. We will then mention how detectors are built starting from this fundamental measurement element.

Integrating MPI and deduplication engines: a software architecture roadmap.

PubMed

Baksi, Dibyendu

2009-03-01

The objective of this paper is to clarify the major concepts related to architecture and design of patient identity management software systems so that an implementor looking to solve a specific integration problem in the context of a Master Patient Index (MPI) and a deduplication engine can address the relevant issues. The ideas presented are illustrated in the context of a reference use case from Integrating the Health Enterprise Patient Identifier Cross-referencing (IHE PIX) profile. Sound software engineering principles using the latest design paradigm of model driven architecture (MDA) are applied to define different views of the architecture. The main contribution of the paper is a clear software architecture roadmap for implementors of patient identity management systems. Conceptual design in terms of static and dynamic views of the interfaces is provided as an example of platform independent model. This makes the roadmap applicable to any specific solutions of MPI, deduplication library or software platform. Stakeholders in need of integration of MPIs and deduplication engines can evaluate vendor specific solutions and software platform technologies in terms of fundamental concepts and can make informed decisions that preserve investment. This also allows freedom from vendor lock-in and the ability to kick-start integration efforts based on a solid architecture.

Fundamentals of Cryogenics

NASA Technical Reports Server (NTRS)

Johnson, Wesley; Tomsik, Thomas; Moder, Jeff

2014-01-01

Analysis of the extreme conditions that are encountered in cryogenic systems requires the most effort out of analysts and engineers. Due to the costs and complexity associated with the extremely cold temperatures involved, testing is sometimes minimized and extra analysis is often relied upon. This short course is designed as an introduction to cryogenic engineering and analysis, and it is intended to introduce the basic concepts related to cryogenic analysis and testing as well as help the analyst understand the impacts of various requests on a test facility. Discussion will revolve around operational functions often found in cryogenic systems, hardware for both tests and facilities, and what design or modelling tools are available for performing the analysis. Emphasis will be placed on what scenarios to use what hardware or the analysis tools to get the desired results. The class will provide a review of first principles, engineering practices, and those relations directly applicable to this subject including such topics as cryogenic fluids, thermodynamics and heat transfer, material properties at low temperature, insulation, cryogenic equipment, instrumentation, refrigeration, testing of cryogenic systems, cryogenics safety and typical thermal and fluid analysis used by the engineer. The class will provide references for further learning on various topics in cryogenics for those who want to dive deeper into the subject or have encountered specific problems.

The 4th Thermodynamic Principle?

DOE Office of Scientific and Technical Information (OSTI.GOV)

Montero Garcia, Jose de la Luz; Novoa Blanco, Jesus Francisco

2007-04-28

It should be emphasized that the 4th Principle above formulated is a thermodynamic principle and, at the same time, is mechanical-quantum and relativist, as it should inevitably be and its absence has been one of main the theoretical limitations of the physical theory until today.We show that the theoretical discovery of Dimensional Primitive Octet of Matter, the 4th Thermodynamic Principle, the Quantum Hexet of Matter, the Global Hexagonal Subsystem of Fundamental Constants of Energy and the Measurement or Connected Global Scale or Universal Existential Interval of the Matter is that it is possible to be arrived at a global formulationmore » of the four 'forces' or fundamental interactions of nature. The Einstein's golden dream is possible.« less

Tissue engineering and regenerative medicine: manufacturing challenges.

PubMed

Williams, D J; Sebastine, I M

2005-12-01

Tissue engineering and regenerative medicine are interdisciplinary fields that apply principles of engineering and life sciences to develop biological substitutes, typically composed of biological and synthetic components, that restore, maintain or improve tissue function. Many tissue engineering technologies are still at a laboratory or pre-commercial scale. The short review paper describes the most significant manufacturing and bio-process challenges inherent in the commercialisation and exploitation of the exciting results emerging from the biological and clinical laboratories exploring tissue engineering and regenerative medicine. A three-generation road map of the industry has been used to structure a view of these challenges and to define where the manufacturing community can contribute to the commercial success of the products from these emerging fields. The first-generation industry is characterised by its demonstrated clinical applications and products in the marketplace, the second is characterised by emerging clinical applications, and the third generation is characterised by aspirational clinical applications. The paper focuses on the cost reduction requirement of the first generation of the industry to allow more market penetration and consequent patient impact. It indicates the technological requirements, for instance the creation of three-dimensional tissue structures, and value chain issues in the second generation of the industry. The third-generation industry challenges lie in fundamental biological and clinical science. The paper sets out a road map of these generations to identify areas for research.

Showcasing Chemical Engineering Principles through the Production of Biodiesel from Spent Coffee Grounds

ERIC Educational Resources Information Center

Bendall, Sophie; Birdsall-Wilson, Max; Jenkins, Rhodri; Chew, Y. M. John; Chuck, Christopher J.

2015-01-01

Chemical engineering is rarely encountered before higher-level education in the U.S. or in Europe, leaving prospective students unaware of what an applied chemistry or chemical engineering degree entails. In this lab experiment, we report the implementation of a three-day course to showcase chemical engineering principles for 16-17 year olds…

Magnetic Resonance with Squeezed Microwaves

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bienfait, A.; Campagne-Ibarcq, P.; Kiilerich, A. H.

2017-10-17

Vacuum fluctuations of the electromagnetic field set a fundamental limit to the sensitivity of a variety of measurements, including magnetic resonance spectroscopy. We report the use of squeezed microwave fields, which are engineered quantum states of light for which fluctuations in one field quadrature are reduced below the vacuum level, to enhance the detection sensitivity of an ensemble of electronic spins at millikelvin temperatures. By shining a squeezed vacuum state on the input port of a microwave resonator containing the spins, we obtain a 1.2-dB noise reduction at the spectrometer output compared to the case of a vacuum input. Thismore » result constitutes a proof of principle of the application of quantum metrology to magnetic resonance spectroscopy.« less

Criticism of generally accepted fundamentals and methodologies of traffic and transportation theory

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kerner, Boris S.

It is explained why the set of the fundamental empirical features of traffic breakdown (a transition from free flow to congested traffic) should be the empirical basis for any traffic and transportation theory that can be reliable used for control and optimization in traffic networks. It is shown that generally accepted fundamentals and methodologies of traffic and transportation theory are not consistent with the set of the fundamental empirical features of traffic breakdown at a highway bottleneck. To these fundamentals and methodologies of traffic and transportation theory belong (i) Lighthill-Whitham-Richards (LWR) theory, (ii) the General Motors (GM) model class (formore » example, Herman, Gazis et al. GM model, Gipps’s model, Payne’s model, Newell’s optimal velocity (OV) model, Wiedemann’s model, Bando et al. OV model, Treiber’s IDM, Krauß’s model), (iii) the understanding of highway capacity as a particular stochastic value, and (iv) principles for traffic and transportation network optimization and control (for example, Wardrop’s user equilibrium (UE) and system optimum (SO) principles). Alternatively to these generally accepted fundamentals and methodologies of traffic and transportation theory, we discuss three-phase traffic theory as the basis for traffic flow modeling as well as briefly consider the network breakdown minimization (BM) principle for the optimization of traffic and transportation networks with road bottlenecks.« less

Statistical Engineering in Air Traffic Management Research

NASA Technical Reports Server (NTRS)

Wilson, Sara R.

2015-01-01

NASA is working to develop an integrated set of advanced technologies to enable efficient arrival operations in high-density terminal airspace for the Next Generation Air Transportation System. This integrated arrival solution is being validated and verified in laboratories and transitioned to a field prototype for an operational demonstration at a major U.S. airport. Within NASA, this is a collaborative effort between Ames and Langley Research Centers involving a multi-year iterative experimentation process. Designing and analyzing a series of sequential batch computer simulations and human-in-the-loop experiments across multiple facilities and simulation environments involves a number of statistical challenges. Experiments conducted in separate laboratories typically have different limitations and constraints, and can take different approaches with respect to the fundamental principles of statistical design of experiments. This often makes it difficult to compare results from multiple experiments and incorporate findings into the next experiment in the series. A statistical engineering approach is being employed within this project to support risk-informed decision making and maximize the knowledge gained within the available resources. This presentation describes a statistical engineering case study from NASA, highlights statistical challenges, and discusses areas where existing statistical methodology is adapted and extended.

Surface- and interface-engineered heterostructures for solar hydrogen generation

NASA Astrophysics Data System (ADS)

Chen, Xiangyan; Li, Yanrui; Shen, Shaohua

2018-04-01

Photoelectrochemical (PEC) water splitting based on semiconductor photoelectrodes provides a promising platform for reducing environmental pollution and solving the energy crisis by developing clean, sustainable and environmentally friendly hydrogen energy. In this context, metal oxides with their advantages including low cost, good chemical stability and environmental friendliness, have attracted extensive attention among the investigated candidates. However, the large bandgap, poor charge transfer ability and high charge recombination rate limit the PEC performance of metal oxides as photoelectrodes. To solve this limitation, many approaches toward enhanced PEC water splitting performance, which focus on surface and interface engineering, have been presented. In this topical review, we concentrate on the heterostructure design of some typical metal oxides with narrow bandgaps (e.g. Fe2O3, WO3, BiVO4 and Cu2O) as photoelectrodes. An overview of the surface- and interface-engineered heterostructures, including semiconductor heterojunctions, surface protection, surface passivation and cocatalyst decoration, will be given to introduce the recent advances in metal oxide heterostructures for PEC water splitting. This article aims to provide fundamental references and principles for designing metal oxide heterostructures with high activity and stability as photoelectrodes for PEC solar hydrogen generation.

Violation of ethical principles in clinical research. Influences and possible solutions for Latin America.

PubMed

Cornejo Moreno, Borys Alberto; Gómez Arteaga, Gress Marissell

2012-12-16

Even though we are now well into the 21st century and notwithstanding all the abuse to individuals involved in clinical studies that has been documented throughout History, fundamental ethical principles continue to be violated in one way or another. Here are some of the main factors that contribute to the abuse of subjects participating in clinical trials: paternalism, improper use of informed consent, lack of strict ethical supervision, pressure exerted by health institutions to increase the production of scientific material, and the absence of legislation regarding ethics in terms of health care and research. Are researchers ready to respect fundamental ethical principles in light of the ample window of information provided by individual genomes, while defending the rights of the subjects participating in clinical studies as a major priority? As one of the possible solutions to this problem, education regarding fundamental ethical principles is suggested for participants in research studies as an initial method of cognitive training in ethics, together with the promotion of ethical behavior in order to encourage the adoption of reasonable policies in the field of values, attitudes and behavior.

Profile of an Effective Engineering Manager at the Naval Avionics Center

DTIC Science & Technology

1991-06-01

GROUP Leadership ; Engineering Management Effectiveness; Engineers; Engineering Managers ; Naval Avionics Center 19 ABSTR. T (Continue on reverse if...Personnel. The purpose of the Institute is to support the implementation of the NAC Leadership / Management Principles throughout NAC. The Leadership ... Management Principles are as follows: - Develc 2 and Maintain a Corporate Outlook. - Communicate the Organizational Vision through Positive Leadership

[The anthropic principle in biology and radiobiology].

PubMed

Akif'ev, A P; Degtiarev, S V

1999-01-01

In accordance with the anthropic principle of the Universe the physical constants of fundamental particles of matter and the laws of their counteraction are those that an appearance of man and mind becomes possible and necessary. It is suggested to add some biological constants to the set of fundamental constants. With reparation of DNA as an example it was shown how a cell ran some parameters of Watson-Crick double helix. It was pointed that the concept of the anthropic principle of the Universe in its full body including biological constants is a key to developing of a unified theory of evolution of the Universe within the limits of scientific creationism.

Fundamentals of Materials, Techniques, and Instrumentation for OSL and FNTD Dosimetry

DOE Office of Scientific and Technical Information (OSTI.GOV)

Akselrod, M. S.

The optically stimulated luminescence (OSL) technique has already become a successful commercial tool in personal radiation dosimetry, medical dosimetry, diagnostic imaging, geological and archeological dating. This review briefly describes the history and fundamental principles of OSL materials, methods and instrumentation. The advantages of OSL technology and instrumentation in comparison with thermoluminescent technique are analyzed. Progress in material and detector engineering has allowed new and promising developments regarding OSL applications in the medical field. Special attention is dedicated to Al{sub 2}O{sub 3}:C as a material of choice for many dosimetric applications. Different aspects of OSL theory, materials optical and dosimetric properties,more » instrumentation, and data processing algorithms are described. The next technological breakthrough was done with Fluorescent Nuclear Track Detectors (FNTD) that have some important advantages in measuring fast neutron and high energy heavy charge particles that have become the latest tool in radiation therapy. New Mg-doped aluminum oxide crystals and novel type of imaging instrumentation for FNTD technology are discussed with regard to application in mixed neutron-gamma fields, medical dosimetry and radiobiological research.« less

Fundamentals of Materials, Techniques, and Instrumentation for OSL and FNTD Dosimetry

NASA Astrophysics Data System (ADS)

Akselrod, M. S.

2011-05-01

The optically stimulated luminescence (OSL) technique has already become a successful commercial tool in personal radiation dosimetry, medical dosimetry, diagnostic imaging, geological and archeological dating. This review briefly describes the history and fundamental principles of OSL materials, methods and instrumentation. The advantages of OSL technology and instrumentation in comparison with thermoluminescent technique are analyzed. Progress in material and detector engineering has allowed new and promising developments regarding OSL applications in the medical field. Special attention is dedicated to Al2O3:C as a material of choice for many dosimetric applications. Different aspects of OSL theory, materials optical and dosimetric properties, instrumentation, and data processing algorithms are described. The next technological breakthrough was done with Fluorescent Nuclear Track Detectors (FNTD) that have some important advantages in measuring fast neutron and high energy heavy charge particles that have become the latest tool in radiation therapy. New Mg-doped aluminum oxide crystals and novel type of imaging instrumentation for FNTD technology are discussed with regard to application in mixed neutron-gamma fields, medical dosimetry and radiobiological research.

Principles to Products: Toward Realizing MOS 2.0

NASA Technical Reports Server (NTRS)

Bindschadler, Duane L.; Delp, Christopher L.

2012-01-01

This is a report on the Operations Revitalization Initiative, part of the ongoing NASA-funded Advanced Multi-Mission Operations Systems (AMMOS) program. We are implementing products that significantly improve efficiency and effectiveness of Mission Operations Systems (MOS) for deep-space missions. We take a multi-mission approach, in keeping with our organization's charter to "provide multi-mission tools and services that enable mission customers to operate at a lower total cost to NASA." Focusing first on architectural fundamentals of the MOS, we review the effort's progress. In particular, we note the use of stakeholder interactions and consideration of past lessons learned to motivate a set of Principles that guide the evolution of the AMMOS. Thus guided, we have created essential patterns and connections (detailed in companion papers) that are explicitly modeled and support elaboration at multiple levels of detail (system, sub-system, element...) throughout a MOS. This architecture is realized in design and implementation products that provide lifecycle support to a Mission at the system and subsystem level. The products include adaptable multi-mission engineering documentation that describes essentials such as operational concepts and scenarios, requirements, interfaces and agreements, information models, and mission operations processes. Because we have adopted a model-based system engineering method, these documents and their contents are meaningfully related to one another and to the system model. This means they are both more rigorous and reusable (from mission to mission) than standard system engineering products. The use of models also enables detailed, early (e.g., formulation phase) insight into the impact of changes (e.g., to interfaces or to software) that is rigorous and complete, allowing better decisions on cost or technical trades. Finally, our work provides clear and rigorous specification of operations needs to software developers, further enabling significant gains in productivity.

A Case for the Need of Using Scaffolding Methods in Teaching Introductory, Fundamental Engineering Mechanics Classes

ERIC Educational Resources Information Center

Boylan-Ashraf, Peggy C.; Freeman, Steven A.; Shelley, Mack C.

2015-01-01

In the past ten years, engineering classrooms have seen an exponential growth in the use of technology, more than during any other previous decade. Unprecedented advancements, such as the advent of innovative gadgets and fundamental instructional alterations in engineering classrooms, have introduced changes in both teaching and learning. Student…

From fundamental supramolecular chemistry to self-assembled nanomaterials and medicines and back again - how Sam inspired SAMul.

PubMed

Smith, David K

2018-05-08

This feature article provides a personal insight into the research from my group over the past 10 years. In particular, the article explains how, inspired in 2005 by meeting my now-husband, Sam, who had cystic fibrosis, and who in 2011 went on to have a double lung transplant, I took an active decision to follow a more applied approach to some of our research, attempting to use fundamental supramolecular chemistry to address problems of medical interest. In particular, our strategy uses self-assembly to fabricate biologically-active nanosystems from simple low-molecular-weight building blocks. These systems can bind biological polyanions in highly competitive conditions, allowing us to approach applications in gene delivery and coagulation control. In the process, however, we have also developed new fundamental principles such as self-assembled multivalency (SAMul), temporary 'on-off' multivalency, and adaptive/shape-persistent multivalent binding. By targeting materials with applications in drug formulation and tissue engineering, we have discovered novel self-assembling low-molecular-weight hydrogelators based on the industrially-relevant dibenzylidenesorbitol framework and developed innovative approaches to spatially-resolved gels and functional multicomponent hybrid hydrogels. In this way, taking an application-led approach to research has also delivered significant academic value and conceptual advances. Furthermore, beginning to translate fundamental supramolecular chemistry into real-world applications, starts to demonstrate the power of this approach, and its potential to transform the world around us for the better.

Regenerative endodontics--Creating new horizons.

PubMed

Dhillon, Harnoor; Kaushik, Mamta; Sharma, Roshni

2016-05-01

Trauma to the dental pulp, physical or microbiologic, can lead to inflammation of the pulp followed by necrosis. The current treatment modality for such cases is non-surgical root canal treatment. The damaged tissue is extirpated and the root canal system prepared. It is then obturated with an inert material such a gutta percha. In spite of advances in techniques and materials, 10%-15% of the cases may end in failure of treatment. Regenerative endodontics combines principles of endodontics, cell biology, and tissue engineering to provide an ideal treatment for inflamed and necrotic pulp. It utilizes mesenchymal stem cells, growth factors, and organ tissue culture to provide treatment. Potential treatment modalities include induction of blood clot for pulp revascularization, scaffold aided regeneration, and pulp implantation. Although in its infancy, successful treatment of damaged pulp tissue has been performed using principles of regenerative endodontics. This field is dynamic and exciting with the ability to shape the future of endodontics. This article highlights the fundamental concepts, protocol for treatment, and possible avenues for research in regenerative endodontics. © 2015 Wiley Periodicals, Inc.

Towards a unified theory for morphomechanics

PubMed Central

Taber, Larry A.

2009-01-01

Mechanical forces are closely involved in the construction of an embryo. Experiments have suggested that mechanical feedback plays a role in regulating these forces, but the nature of this feedback is poorly understood. Here, we propose a general principle for the mechanics of morphogenesis, as governed by a pair of evolution equations based on feedback from tissue stress. In one equation, the rate of growth (or contraction) depends on the difference between the current tissue stress and a target (homeostatic) stress. In the other equation, the target stress changes at a rate that depends on the same stress difference. The parameters in these morphomechanical laws are assumed to depend on stress rate. Computational models are used to illustrate how these equations can capture a relatively wide range of behaviours observed in developing embryos, as well as show the limitations of this theory. Specific applications include growth of pressure vessels (e.g. the heart, arteries and brain), wound healing and sea urchin gastrulation. Understanding the fundamental principles of tissue construction can help engineers design new strategies for creating replacement tissues and organs in vitro. PMID:19657011

Cellular organization of cortical barrel columns is whisker-specific

PubMed Central

Meyer, Hanno S.; Egger, Robert; Guest, Jason M.; Foerster, Rita; Reissl, Stefan; Oberlaender, Marcel

2013-01-01

The cellular organization of the cortex is of fundamental importance for elucidating the structural principles that underlie its functions. It has been suggested that reconstructing the structure and synaptic wiring of the elementary functional building block of mammalian cortices, the cortical column, might suffice to reverse engineer and simulate the functions of entire cortices. In the vibrissal area of rodent somatosensory cortex, whisker-related “barrel” columns have been referred to as potential cytoarchitectonic equivalents of functional cortical columns. Here, we investigated the structural stereotypy of cortical barrel columns by measuring the 3D neuronal composition of the entire vibrissal area in rat somatosensory cortex and thalamus. We found that the number of neurons per cortical barrel column and thalamic “barreloid” varied substantially within individual animals, increasing by ∼2.5-fold from dorsal to ventral whiskers. As a result, the ratio between whisker-specific thalamic and cortical neurons was remarkably constant. Thus, we hypothesize that the cellular architecture of sensory cortices reflects the degree of similarity in sensory input and not columnar and/or cortical uniformity principles. PMID:24101458

A search for the double-beta decay of Xenon-136 to an excited state of Barium-136 with exo-200

NASA Astrophysics Data System (ADS)

Yee, Shannon Koa

While greater than 80% of all electricity continues to be generated by heat engines, methods of directly converting heat into electricity will remain appealing. Thermoelectric generators are one technology that is capable of doing this but the low efficiency and high cost has limited their terrestrial deployment. Thermoelectrics are compact, solid state devices, without moving parts that directly convert a temperature difference into a voltage. Developing better thermoelectric materials is challenging and requires that materials be engineered with new transport physics. The interface between organic and inorganic materials is one example where new transport physics manifests. Therefore, it is possible that improvements in thermoelectrics can be made by engineering organic-inorganic hybrid thermoelectric materials. Composite materials exhibit characteristics of their constituents where hybrid materials possess new properties that are distinctly different from their constituents. At the interface between organic and inorganic materials, hybrid properties manifest. One ideal system to understand this interface is in a metal-molecule-metal junction commonly referred to as a molecular junction. This is often a result of the discrete electronic energy levels of the organic hybridizing with the continuum of electronic states in the inorganic. Herein, new transport phenomenon is observed in molecular junctions, which have great promise for thermoelectrics. It is observed that the transport property are positively correlated breaking the historic trends to improving thermoelectric efficiency. Towards the goal of higher efficiency thermoelectrics, the fundamental science of interfaces is first investigated in molecular junctions. Guiding principles from these fundamental studies are then applied to engineer a bulk, polymer-based, thermoelectric materials with high efficiency. These improvements are encouraging and motivated a cost analysis to evaluate their current market potential against competing thermoelectric materials. In all, this dissertation marks the progress in developing a new class of hybrid organic-inorganic materials for thermoelectric applications.

New Principles and Basic Approaches for the Curricula of Engineering Degree Courses.

ERIC Educational Resources Information Center

Gargione, Luiz Antonio

This paper presents new principles and basic approaches for the curricula of engineering degree courses. The accentuated evolution of engineering, the fast technological transformations and, still, the impact provoked by government regulations in the field of education in Brazil have called attention to these issues. Following these changes, it…

Engineering Codes of Ethics and the Duty to Set a Moral Precedent.

PubMed

Schlossberger, Eugene

2016-10-01

Each of the major engineering societies has its own code of ethics. Seven "common core" clauses and several code-specific clauses can be identified. The paper articulates objections to and rationales for two clauses that raise controversy: do engineers have a duty (a) to provide pro bono services and/or speak out on major issues, and (b) to associate only with reputable individuals and organizations? This latter "association clause" can be justified by the "proclamative principle," an alternative to Kant's universalizability requirement. At the heart of engineering codes of ethics, and implicit in what it is to be a moral agent, the "proclamative principle" asserts that one's life should proclaim one's moral stances (one's values, principles, perceptions, etc.). More specifically, it directs engineers to strive to insure that their actions, thoughts, and relationships be fit to offer to their communities as part of the body of moral precedents for how to be an engineer. Understanding codes of ethics as reflections of this principle casts light both on how to apply the codes and on the distinction between private and professional morality.

An Introduction to the Fundamentals of Chemistry for the Marine Engineer.

ERIC Educational Resources Information Center

Schlenker, Richard M.

This document describes an introduction course in the fundamentals of chemistry for marine engineers. The course is modularized, audio tutorial allowing the student to progress at his own rate while integrating laboratory and lecture materials. (SL)

Microscopic Description of Le Chatelier's Principle

ERIC Educational Resources Information Center

Novak, Igor

2005-01-01

A simple approach that "demystifies" Le Chatelier's principle (LCP) and simulates students to think about fundamental physical background behind the well-known principles is presented. The approach uses microscopic descriptors of matter like energy levels and populations and does not require any assumption about the fixed amount of substance being…

What Constitutes Science and Scientific Evidence: Roles of Null Hypothesis Testing

ERIC Educational Resources Information Center

Chang, Mark

2017-01-01

We briefly discuss the philosophical basis of science, causality, and scientific evidence, by introducing the hidden but most fundamental principle of science: the similarity principle. The principle's use in scientific discovery is illustrated with Simpson's paradox and other examples. In discussing the value of null hypothesis statistical…

Integration of Social Studies Principles in the Home Economics Curriculum.

ERIC Educational Resources Information Center

Texas Tech Univ., Lubbock. Home Economics Curriculum Center.

This document is intended to help secondary home economics teachers incorporate social studies principles into their curriculum. After an introduction, the document is divided into three sections. The first section identifies and explains fundamental principles within social studies and covers the history and current state of the social studies…

Sensors, Volume 1, Fundamentals and General Aspects

NASA Astrophysics Data System (ADS)

Grandke, Thomas; Ko, Wen H.

1996-12-01

'Sensors' is the first self-contained series to deal with the whole area of sensors. It describes general aspects, technical and physical fundamentals, construction, function, applications and developments of the various types of sensors. This volume deals with the fundamentals and common principles of sensors and covers the wide areas of principles, technologies, signal processing, and applications. Contents include: Sensor Fundamentals, e.g. Sensor Parameters, Modeling, Design and Packaging; Basic Sensor Technologies, e.g. Thin and Thick Films, Integrated Magnetic Sensors, Optical Fibres and Intergrated Optics, Ceramics and Oxides; Sensor Interfaces, e.g. Signal Processing, Multisensor Signal Processing, Smart Sensors, Interface Systems; Sensor Applications, e.g. Automotive: On-board Sensors, Traffic Surveillance and Control, Home Appliances, Environmental Monitoring, etc. This volume is an indispensable reference work and text book for both specialits and newcomers, researchers and developers.

Computational intelligence from AI to BI to NI

NASA Astrophysics Data System (ADS)

Werbos, Paul J.

2015-05-01

This paper gives highlights of the history of the neural network field, stressing the fundamental ideas which have been in play. Early neural network research was motivated mainly by the goals of artificial intelligence (AI) and of functional neuroscience (biological intelligence, BI), but the field almost died due to frustrations articulated in the famous book Perceptrons by Minsky and Papert. When I found a way to overcome the difficulties by 1974, the community mindset was very resistant to change; it was not until 1987/1988 that the field was reborn in a spectacular way, leading to the organized communities now in place. Even then, it took many more years to establish crossdisciplinary research in the types of mathematical neural networks needed to really understand the kind of intelligence we see in the brain, and to address the most demanding engineering applications. Only through a new (albeit short-lived) funding initiative, funding crossdisciplinary teams of systems engineers and neuroscientists, were we able to fund the critical empirical demonstrations which put our old basic principle of "deep learning" firmly on the map in computer science. Progress has rightly been inhibited at times by legitimate concerns about the "Terminator threat" and other possible abuses of technology. This year, at SPIE, in the quantum computing track, we outline the next stage ahead of us in breaking out of the box, again and again, and rising to fundamental challenges and opportunities still ahead of us.

78 FR 44627 - HOME Investment Partnerships Program: Improving Performance and Accountability; Updating Property...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-24

... (Faith-Based Activities) to reflect the amendments made by Executive Order 13559 (Fundamental Principles... several important values and principles of community development. First, the HOME program's flexibility is...

A systems approach to theoretical fluid mechanics: Fundamentals

NASA Technical Reports Server (NTRS)

Anyiwo, J. C.

1978-01-01

A preliminary application of the underlying principles of the investigator's general system theory to the description and analyses of the fluid flow system is presented. An attempt is made to establish practical models, or elements of the general fluid flow system from the point of view of the general system theory fundamental principles. Results obtained are applied to a simple experimental fluid flow system, as test case, with particular emphasis on the understanding of fluid flow instability, transition and turbulence.

[Participation of forensic medical experts in the examination at the place of occurrence: fundamental legal principles and organizational aspects].

PubMed

Kachina, N N

2013-01-01

Discussed in this paper are fundamental legal principles and organizational aspects of the participation of forensic medical experts in the examination of the corpses at the place of occurrence. A detailed analysis of the current departmental and sectoral regulations governing the activities of specialists in the field of forensic medicine was performed The analysis demonstrated their positive and negative aspects. These findings were used to develop concrete recommendations for further improvement of these documents.

The Fundamentals of an African American Value System.

ERIC Educational Resources Information Center

Alexander, E. Curtis

The Nguzo Saba or "Seven Principles of Blackness" provide the fundamental basis for the development of an African America value system that is based on the cultural and historical particularisms of being Black in an American society that devalues Black efficacy and Black people. The fundamentals of this value system, foundational to the Kwanzaa…

The Subordination of Aesthetic Fundamentals in College Art Instruction

ERIC Educational Resources Information Center

Lavender, Randall

2003-01-01

Opportunities for college students of art and design to study fundamentals of visual aesthetics, integrity of form, and principles of composition are limited today by a number of factors. With the well-documented prominence of postmodern critical theory in the world of contemporary art, the study of aesthetic fundamentals is largely subordinated…

Hall thruster with grooved walls

DOE Office of Scientific and Technical Information (OSTI.GOV)

Li Hong; Ning Zhongxi; Yu Daren

2013-02-28

Axial-oriented and azimuthal-distributed grooves are formed on channel walls of a Hall thruster after the engine undergoes a long-term operation. Existing studies have demonstrated the relation between the grooves and the near-wall physics, such as sheath and electron near-wall transport. The idea to optimize the thruster performance with such grooves was also proposed. Therefore, this paper is devoted to explore the effects of wall grooves on the discharge characteristics of a Hall thruster. With experimental measurements, the variations on electron conductivity, ionization distribution, and integrated performance are obtained. The involved physical mechanisms are then analyzed and discussed. The findings helpmore » to not only better understand the working principle of Hall thruster discharge but also establish a physical fundamental for the subsequent optimization with artificial grooves.« less

Expanded scope of training and education programs at the UFTR

DOE Office of Scientific and Technical Information (OSTI.GOV)

Vernetson, W.G.; Whaley, P.M.

1985-01-01

Historically, the University of Florida Training Reactor (UFTR) has been used to train both hot and cold license reactor operator candidates in intensive two- and three-week training programs consisting of a correlated set of classroom lectures, hands-on reactor operations, and laboratory exercises. These training programs provide nuclear plant operating staff with fundamental operational experience in understanding, controlling, and evaluating subcritical multiplication, reactivity effects, reactivity manipulations, and reactor operations; a sufficient number of startups and shutdowns is also assured. The UDTR is also used in a nuclear engineering course entitled ''Principles of Nuclear Reactor Operations.'' The purpose of this paper ismore » to report the results of efforts to redirect and refine tractor operations educational and training programs at the UFTR.« less

Electric-field noise from carbon-adatom diffusion on a Au(110) surface: First-principles calculations and experiments

NASA Astrophysics Data System (ADS)

Kim, E.; Safavi-Naini, A.; Hite, D. A.; McKay, K. S.; Pappas, D. P.; Weck, P. F.; Sadeghpour, H. R.

2017-03-01

The decoherence of trapped-ion quantum gates due to heating of their motional modes is a fundamental science and engineering problem. This heating is attributed to electric-field noise arising from the trap-electrode surfaces. In this work, we investigate the source of this noise by focusing on the diffusion of carbon-containing adsorbates on the surface of Au(110). We show by density functional theory, based on detailed scanning probe microscopy, how the carbon adatom diffusion on the gold surface changes the energy landscape and how the adatom dipole moment varies with the diffusive motion. A simple model for the diffusion noise, which varies quadratically with the variation of the dipole moment, predicts a noise spectrum, in accordance with the measured values.

NASA systems engineering handbook

NASA Astrophysics Data System (ADS)

Shishko, Robert; Aster, Robert; Chamberlain, Robert G.; McDuffee, Patrick; Pieniazek, Les; Rowell, Tom; Bain, Beth; Cox, Renee I.; Mooz, Harold; Polaski, Lou

1995-06-01

This handbook brings the fundamental concepts and techniques of systems engineering to NASA personnel in a way that recognizes the nature of NASA systems and environment. It is intended to accompany formal NASA training courses on systems engineering and project management when appropriate, and is designed to be a top-level overview. The concepts were drawn from NASA field center handbooks, NMI's/NHB's, the work of the NASA-wide Systems Engineering Working Group and the Systems Engineering Process Improvement Task team, several non-NASA textbooks and guides, and material from independent systems engineering courses taught to NASA personnel. Five core chapters cover systems engineering fundamentals, the NASA Project Cycle, management issues in systems engineering, systems analysis and modeling, and specialty engineering integration. It is not intended as a directive.

Understanding Molecular Conduction: Old Wine in a New Bottle?

NASA Astrophysics Data System (ADS)

Ghosh, Avik

2007-03-01

Molecules provide an opportunity to test our understanding of fundamental non-equilibrium transport processes, as well as explore new device possibilities. We have developed a unified approach to nanoscale conduction, coupling bandstructure and electrostatics of the channel and contacts with a quantum kinetic theory of current flow. This allows us to describe molecular conduction at various levels of detail, -- from quantum corrected compact models, to semi-empirical models for quick physical insights, and `first-principles' calculations of current-voltage (I-V) characteristics with no adjustable parameters. Using this suite of tools, we can quantitatively explain various experimental I-Vs, including complex reconstructed silicon substrates. We find that conduction in most molecules is contact dominated, and limited by fundamental electrostatic and thermodynamic restrictions quite analogous to those faced by the silicon industry, barring a few interesting exceptions. The distinction between molecular and silicon electronics must therefore be probed at a more fundamental level. Ultra-short molecules are unique in that they possess large Coulomb energies as well as anomalous vibronic couplings with current flow -- in other words, strong non-equilibrium electron-electron and electron-phonon correlations. These effects yield prominent experimental signatures, but require a completely different modeling approach -- in fact, popular approaches to include correlation typically do not work for non-equilibrium. Molecules exhibit rich physics, including the ability to function both as weakly interacting current conduits (quantum wires) as well as strongly correlated charge storage centers (quantum dots). Theoretical treatment of the intermediate coupling regime is particularly challenging, with a large `fine structure constant' for transport that negates orthodox theories of Coulomb Blockade and phonon-assisted tunneling. It is in this regime that the scientific and technological merits of molecular conductors may need to be explored. For instance, the tunable quantum coupling of current flow in silicon transistors with engineered molecular scatterers could lead to devices that operate on completely novel principles.

Causal Mathematical Logic as a guiding framework for the prediction of "Intelligence Signals" in brain simulations

NASA Astrophysics Data System (ADS)

Lanzalaco, Felix; Pissanetzky, Sergio

2013-12-01

A recent theory of physical information based on the fundamental principles of causality and thermodynamics has proposed that a large number of observable life and intelligence signals can be described in terms of the Causal Mathematical Logic (CML), which is proposed to encode the natural principles of intelligence across any physical domain and substrate. We attempt to expound the current definition of CML, the "Action functional" as a theory in terms of its ability to possess a superior explanatory power for the current neuroscientific data we use to measure the mammalian brains "intelligence" processes at its most general biophysical level. Brain simulation projects define their success partly in terms of the emergence of "non-explicitly programmed" complex biophysical signals such as self-oscillation and spreading cortical waves. Here we propose to extend the causal theory to predict and guide the understanding of these more complex emergent "intelligence Signals". To achieve this we review whether causal logic is consistent with, can explain and predict the function of complete perceptual processes associated with intelligence. Primarily those are defined as the range of Event Related Potentials (ERP) which include their primary subcomponents; Event Related Desynchronization (ERD) and Event Related Synchronization (ERS). This approach is aiming for a universal and predictive logic for neurosimulation and AGi. The result of this investigation has produced a general "Information Engine" model from translation of the ERD and ERS. The CML algorithm run in terms of action cost predicts ERP signal contents and is consistent with the fundamental laws of thermodynamics. A working substrate independent natural information logic would be a major asset. An information theory consistent with fundamental physics can be an AGi. It can also operate within genetic information space and provides a roadmap to understand the live biophysical operation of the phenotype

State of the art and future needs in S.I. engine combustion

DOE Office of Scientific and Technical Information (OSTI.GOV)

Maly, R.R.

1994-12-31

The paper reviews, in short, the state-of-the-art in SI engine combustion by addressing its main features: mixture formation, ignition, homogeneous combustion, pollutant formation, knock, and engine modeling. Necessary links between fundamental and practical work are clarified and discussed along with advanced diagnostics and simulation tools. The needs for further work are identified, the most important one being integration of all fundamental and practical resources to meet R and D requirements for future engines.

AUTOMOTIVE DIESEL MAINTENANCE 2. UNIT XVI, LEARNING ABOUT AC GENERATOR (ALTERNATOR) PRINCIPLES (PART I).

ERIC Educational Resources Information Center

Human Engineering Inst., Cleveland, OH.

THIS MODULE OF A 25-MODULE COURSE IS DESIGNED TO DEVELOP AN UNDERSTANDING OF THE OPERATING PRINCIPLES OF ALTERNATING CURRENT GENERATORS USED ON DIESEL POWERED EQUIPMENT. TOPICS ARE REVIEWING ELECTRICAL FUNDAMENTALS, AND OPERATING PRINCIPLES OF ALTERNATORS. THE MODULE CONSISTS OF A SELF-INSTRUCTIONAL PROGRAMED TRAINING FILM "AC GENERATORS…

Teaching about Due Process of Law. ERIC Digest.

ERIC Educational Resources Information Center

Vontz, Thomas S.

Fundamental constitutional and legal principles are central to effective instruction in the K-12 social studies curriculum. To become competent citizens, students need to develop an understanding of the principles on which their society and government are based. Few principles are as important in the social studies curriculum as due process of…

Precautionary Principles: General Definitions and Specific Applications to Genetically Modified Organisms

ERIC Educational Resources Information Center

Lofstedt, Ragnar E.; Fischhoff, Baruch; Fischhoff, Ilya R.

2002-01-01

Precautionary principles have been proposed as a fundamental element of sound risk management. Their advocates see them as guiding action in the face of uncertainty, encouraging the adoption of measures that reduce serious risks to health, safety, and the environment. Their opponents may reject the very idea of precautionary principles, find…

[Fundamental principles of social work--(also) a contribution to public health ethics].

PubMed

Lob-Hüdepohl, A

2009-05-01

Social work and public health are different but mutually connected. Both are professions with their own ethical foundations. Despite all differences, they have the same goal: to protect and to enhance the well-being of people. This is, in part, why the fundamental ethical principles of social work are salient for developing public health ethics. As a human rights profession, social work respects the personal autonomy of clients, supports solidarity-based relationships in families, groups or communities, and attempts to uphold social justice in society. Social workers need to adopt special professional attitudes: sensibility for the vulnerabilities of clients, care and attentiveness for their resources and strengths, assistance instead of paternalistic care and advocacy in decision making for clients' well-being when clients are not able to decide for themselves. These fundamental ethical principles are the basis for discussion of special topics of social work ethics as public health ethics, for example, in justifying intervention in individual lifestyles by public services without the participation or consent of the affected persons.

Interface design and human factors considerations for model-based tight glycemic control in critical care.

PubMed

Ward, Logan; Steel, James; Le Compte, Aaron; Evans, Alicia; Tan, Chia-Siong; Penning, Sophie; Shaw, Geoffrey M; Desaive, Thomas; Chase, J Geoffrey

2012-01-01

Tight glycemic control (TGC) has shown benefits but has been difficult to implement. Model-based methods and computerized protocols offer the opportunity to improve TGC quality and compliance. This research presents an interface design to maximize compliance, minimize real and perceived clinical effort, and minimize error based on simple human factors and end user input. The graphical user interface (GUI) design is presented by construction based on a series of simple, short design criteria based on fundamental human factors engineering and includes the use of user feedback and focus groups comprising nursing staff at Christchurch Hospital. The overall design maximizes ease of use and minimizes (unnecessary) interaction and use. It is coupled to a protocol that allows nurse staff to select measurement intervals and thus self-manage workload. The overall GUI design is presented and requires only one data entry point per intervention cycle. The design and main interface are heavily focused on the nurse end users who are the predominant users, while additional detailed and longitudinal data, which are of interest to doctors guiding overall patient care, are available via tabs. This dichotomy of needs and interests based on the end user's immediate focus and goals shows how interfaces must adapt to offer different information to multiple types of users. The interface is designed to minimize real and perceived clinical effort, and ongoing pilot trials have reported high levels of acceptance. The overall design principles, approach, and testing methods are based on fundamental human factors principles designed to reduce user effort and error and are readily generalizable. © 2012 Diabetes Technology Society.

Interface Design and Human Factors Considerations for Model-Based Tight Glycemic Control in Critical Care

PubMed Central

Ward, Logan; Steel, James; Le Compte, Aaron; Evans, Alicia; Tan, Chia-Siong; Penning, Sophie; Shaw, Geoffrey M; Desaive, Thomas; Chase, J Geoffrey

2012-01-01

Introduction Tight glycemic control (TGC) has shown benefits but has been difficult to implement. Model-based methods and computerized protocols offer the opportunity to improve TGC quality and compliance. This research presents an interface design to maximize compliance, minimize real and perceived clinical effort, and minimize error based on simple human factors and end user input. Method The graphical user interface (GUI) design is presented by construction based on a series of simple, short design criteria based on fundamental human factors engineering and includes the use of user feedback and focus groups comprising nursing staff at Christchurch Hospital. The overall design maximizes ease of use and minimizes (unnecessary) interaction and use. It is coupled to a protocol that allows nurse staff to select measurement intervals and thus self-manage workload. Results The overall GUI design is presented and requires only one data entry point per intervention cycle. The design and main interface are heavily focused on the nurse end users who are the predominant users, while additional detailed and longitudinal data, which are of interest to doctors guiding overall patient care, are available via tabs. This dichotomy of needs and interests based on the end user's immediate focus and goals shows how interfaces must adapt to offer different information to multiple types of users. Conclusions The interface is designed to minimize real and perceived clinical effort, and ongoing pilot trials have reported high levels of acceptance. The overall design principles, approach, and testing methods are based on fundamental human factors principles designed to reduce user effort and error and are readily generalizable. PMID:22401330

Lessons Learned in Engineering

NASA Technical Reports Server (NTRS)

Blair, J. C.; Ryan, R. S.; Schutzenhofer, L. A.

2011-01-01

This Contractor Report (CR) is a compilation of Lessons Learned in approximately 55 years of engineering experience by each James C. Blair, Robert S. Ryan, and Luke A. Schutzenhofer. The lessons are the basis of a course on Lessons Learned that has been taught at Marshall Space Flight Center. The lessons are drawn from NASA space projects and are characterized in terms of generic lessons learned from the project experience, which are further distilled into overarching principles that can be applied to future projects. Included are discussions of the overarching principles followed by a listing of the lessons associated with that principle. The lesson with sub-lessons are stated along with a listing of the project problems the lesson is drawn from, then each problem is illustrated and discussed, with conclusions drawn in terms of Lessons Learned. The purpose of this CR is to provide principles learned from past aerospace experience to help achieve greater success in future programs, and identify application of these principles to space systems design. The problems experienced provide insight into the engineering process and are examples of the subtleties one experiences performing engineering design, manufacturing, and operations.

The Future of Pharmaceutical Manufacturing Sciences

PubMed Central

2015-01-01

The entire pharmaceutical sector is in an urgent need of both innovative technological solutions and fundamental scientific work, enabling the production of highly engineered drug products. Commercial‐scale manufacturing of complex drug delivery systems (DDSs) using the existing technologies is challenging. This review covers important elements of manufacturing sciences, beginning with risk management strategies and design of experiments (DoE) techniques. Experimental techniques should, where possible, be supported by computational approaches. With that regard, state‐of‐art mechanistic process modeling techniques are described in detail. Implementation of materials science tools paves the way to molecular‐based processing of future DDSs. A snapshot of some of the existing tools is presented. Additionally, general engineering principles are discussed covering process measurement and process control solutions. Last part of the review addresses future manufacturing solutions, covering continuous processing and, specifically, hot‐melt processing and printing‐based technologies. Finally, challenges related to implementing these technologies as a part of future health care systems are discussed. © 2015 The Authors. Journal of Pharmaceutical Sciences published by Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 104:3612–3638, 2015 PMID:26280993

Deciphering the Principles of Bacterial Nitrogen Dietary Preferences: a Strategy for Nutrient Containment

PubMed Central

Wang, Jilong; Yan, Dalai

2016-01-01

ABSTRACT A fundamental question in microbial physiology concerns why organisms prefer certain nutrients to others. For example, among different nitrogen sources, ammonium is the preferred nitrogen source, supporting fast growth, whereas alternative nitrogen sources, such as certain amino acids, are considered to be poor nitrogen sources, supporting much slower exponential growth. However, the physiological/regulatory logic behind such nitrogen dietary choices remains elusive. In this study, by engineering Escherichia coli, we switched the dietary preferences toward amino acids, with growth rates equivalent to that of the wild-type strain grown on ammonia. However, when the engineered strain was cultured together with wild-type E. coli, this growth advantage was diminished as a consequence of ammonium leakage from the transport-and-catabolism (TC)-enhanced (TCE) cells, which are preferentially utilized by wild-type bacteria. Our results reveal that the nitrogen regulatory (Ntr) system fine tunes the expression of amino acid transport and catabolism components to match the flux through the ammonia assimilation pathway such that essential nutrients are retained, but, as a consequence, the fast growth rate on amino acids is sacrificed. PMID:27435461

Preface

NASA Astrophysics Data System (ADS)

Faybishenko, Boris; Witherspoon, Paul A.; Gale, John

How to characterize fluid flow, heat, and chemical transport in geologic media remains a central challenge for geoscientists and engineers worldwide. Investigations of fluid flow and transport within rock relate to such fundamental and applied problems as environmental remediation; nonaqueous phase liquid (NAPL) transport; exploitation of oil, gas, and geothermal resources; disposal of spent nuclear fuel; and geotechnical engineering. It is widely acknowledged that fractures in unsaturated-saturated rock can play a major role in solute transport from the land surface to underlying aquifers. It is also evident that general issues concerning flow and transport predictions in subsurface fractured zones can be resolved in a practical manner by integrating investigations into the physical nature of flow in fractures, developing relevant mathematical models and modeling approaches, and collecting site characterization data. Because of the complexity of flow and transport processes in most fractured rock flow problems, it is not yet possible to develop models directly from first principles. One reason for this is the presence of episodic, preferential water seepage and solute transport, which usually proceed more rapidly than expected from volume-averaged and time-averaged models. However, the physics of these processes is still known.

The Future of Pharmaceutical Manufacturing Sciences.

PubMed

Rantanen, Jukka; Khinast, Johannes

2015-11-01

The entire pharmaceutical sector is in an urgent need of both innovative technological solutions and fundamental scientific work, enabling the production of highly engineered drug products. Commercial-scale manufacturing of complex drug delivery systems (DDSs) using the existing technologies is challenging. This review covers important elements of manufacturing sciences, beginning with risk management strategies and design of experiments (DoE) techniques. Experimental techniques should, where possible, be supported by computational approaches. With that regard, state-of-art mechanistic process modeling techniques are described in detail. Implementation of materials science tools paves the way to molecular-based processing of future DDSs. A snapshot of some of the existing tools is presented. Additionally, general engineering principles are discussed covering process measurement and process control solutions. Last part of the review addresses future manufacturing solutions, covering continuous processing and, specifically, hot-melt processing and printing-based technologies. Finally, challenges related to implementing these technologies as a part of future health care systems are discussed. © 2015 The Authors. Journal of Pharmaceutical Sciences published by Wiley Periodicals, Inc. and the American Pharmacists Association.

Training mechanical engineering students to utilize biological inspiration during product development.

PubMed

Bruck, Hugh A; Gershon, Alan L; Golden, Ira; Gupta, Satyandra K; Gyger, Lawrence S; Magrab, Edward B; Spranklin, Brent W

2007-12-01

The use of bio-inspiration for the development of new products and devices requires new educational tools for students consisting of appropriate design and manufacturing technologies, as well as curriculum. At the University of Maryland, new educational tools have been developed that introduce bio-inspired product realization to undergraduate mechanical engineering students. These tools include the development of a bio-inspired design repository, a concurrent fabrication and assembly manufacturing technology, a series of undergraduate curriculum modules and a new senior elective in the bio-inspired robotics area. This paper first presents an overview of the two new design and manufacturing technologies that enable students to realize bio-inspired products, and describes how these technologies are integrated into the undergraduate educational experience. Then, the undergraduate curriculum modules are presented, which provide students with the fundamental design and manufacturing principles needed to support bio-inspired product and device development. Finally, an elective bio-inspired robotics project course is present, which provides undergraduates with the opportunity to demonstrate the application of the knowledge acquired through the curriculum modules in their senior year using the new design and manufacturing technologies.

The role of hardware in learning engineering fundamentals: An empirical study of engineering design and product analysis activity

NASA Astrophysics Data System (ADS)

Brereton, Margot Felicity

A series of short engineering exercises and design projects was created to help students learn to apply abstract knowledge to physical experiences with hardware. The exercises involved designing machines from kits of materials and dissecting and analyzing familiar household products. Students worked in teams. During the activities students brought their knowledge of engineering fundamentals to bear. Videotape analysis was used to identify and characterize the ways in which hardware contributed to learning fundamental concepts. Structural and qualitative analyses of videotaped activities were undertaken. Structural analysis involved counting the references to theory and hardware and the extent of interleaving of references in activity. The analysis found that there was much more discussion linking fundamental concepts to hardware in some activities than in others. The analysis showed that the interleaving of references to theory and hardware in activity is observable and quantifiable. Qualitative analysis was used to investigate the dialog linking concepts and hardware. Students were found to advance their designs and their understanding of engineering fundamentals through a negotiation process in which they pitted abstract concepts against hardware behavior. Through this process students sorted out theoretical assumptions and causal relations. In addition they discovered design assumptions, functional connections and physical embodiments of abstract concepts in hardware, developing a repertoire of familiar hardware components and machines. Hardware was found to be integral to learning, affecting the course of inquiry and the dynamics of group interaction. Several case studies are presented to illustrate the processes at work. The research illustrates the importance of working across the boundary between abstractions and experiences with hardware in order to learn engineering and physical sciences. The research findings are: (a) the negotiation process by which students discover fundamental concepts in hardware (and three central causes of negotiation breakdown); (b) a characterization of the ways that material systems contribute to learning activities, (the seven roles of hardware in learning); (c) the characteristics of activities that support discovering fundamental concepts in hardware (plus several engineering exercises); (d) a research methodology to examine how students learn in practice.

The School Office: An Overview.

ERIC Educational Resources Information Center

Hudson, Randy

2000-01-01

Presents an overview of the fundamental principles of school office design that remain constant despite changes in building technologies, and technological and spatial flexibility. Principles discussed include the school office and traffic patterns, security, and visitor reception requirements. (GR)

Joint electrical engineering/physics course sequence for optics fundamentals and design

NASA Astrophysics Data System (ADS)

Magnusson, Robert; Maldonado, Theresa A.; Black, Truman D.

2000-06-01

Optics is a key technology in a broad range of engineering and science applications of high national priority. Engineers and scientists with a sound background in this field are needed to preserve technical leadership and to establish new directions of research and development. To meet this educational need, a joint Electrical Engineering/Physics optics course sequence was created as PHYS 3445 Fundamentals of Optics and EE 4444 Optical Systems Design, both with a laboratory component. The objectives are to educate EE and Physics undergraduate students in the fundamentals of optics; in interdisciplinary problem solving; in design and analysis; in handling optical components; and in skills such as communications and team cooperation. Written technical reports in professional format are required, formal presentations are given, and participation in paper design contests is encouraged.

NASA Systems Engineering Handbook

NASA Technical Reports Server (NTRS)

Shishko, Robert; Aster, Robert; Chamberlain, Robert G.; Mcduffee, Patrick; Pieniazek, Les; Rowell, Tom; Bain, Beth; Cox, Renee I.; Mooz, Harold; Polaski, Lou

1995-01-01

This handbook brings the fundamental concepts and techniques of systems engineering to NASA personnel in a way that recognizes the nature of NASA systems and environment. It is intended to accompany formal NASA training courses on systems engineering and project management when appropriate, and is designed to be a top-level overview. The concepts were drawn from NASA field center handbooks, NMI's/NHB's, the work of the NASA-wide Systems Engineering Working Group and the Systems Engineering Process Improvement Task team, several non-NASA textbooks and guides, and material from independent systems engineering courses taught to NASA personnel. Five core chapters cover systems engineering fundamentals, the NASA Project Cycle, management issues in systems engineering, systems analysis and modeling, and specialty engineering integration. It is not intended as a directive. Superseded by: NASA/SP-2007-6105 Rev 1 (20080008301).

22 CFR 120.11 - Public domain.

Code of Federal Regulations, 2010 CFR

2010-04-01

.... Fundamental research is defined to mean basic and applied research in science and engineering where the... fundamental research in science and engineering at accredited institutions of higher learning in the U.S... distinguished from research the results of which are restricted for proprietary reasons or specific U.S...

Homeschooling and Religious Fundamentalism

ERIC Educational Resources Information Center

Kunzman, Robert

2010-01-01

This article considers the relationship between homeschooling and religious fundamentalism by focusing on their intersection in the philosophies and practices of conservative Christian homeschoolers in the United States. Homeschooling provides an ideal educational setting to support several core fundamentalist principles: resistance to…

Competency Test Items for Applied Principles of Agribusiness and Natural Resources Occupations. Agricultural Mechanics Component. A Report of Research.

ERIC Educational Resources Information Center

Cheek, Jimmy G.; McGhee, Max B.

An activity was undertaken to develop written criterion-referenced tests for the agricultural mechanics component of the Applied Principles of Agribusiness and Natural Resources. Intended for tenth grade students who have completed Fundamentals of Agribusiness and Natural Resources Occupations, applied principles were designed to consist of three…

Competency Test Items for Applied Principles of Agribusiness and Natural Resources Occupations. Common Core Component. A Report of Research.

ERIC Educational Resources Information Center

Cheek, Jimmy G.; McGhee, Max B.

An activity was undertaken to develop written criterion-referenced tests for the common core component of Applied Principles of Agribusiness and Natural Resources Occupations. Intended for tenth grade students who have completed Fundamentals of Agribusiness and Natural Resources Occupations, applied principles were designed to consist of three…

Competency Test Items for Applied Principles of Agribusiness and Natural Resources Occupations. Forestry Component. A Report of Research.

ERIC Educational Resources Information Center

Cheek, Jimmy G.; McGhee, Max B.

An activity was undertaken to develop written criterion-referenced tests for the forestry component of Applied Principles of Agribusiness and Natural Resources. Intended for tenth grade students who have completed Fundamentals of Agribusiness and Natural Resources Occupations, applied principles were designed to consist of three components, with…

Competency Test Items for Applied Principles of Agribusiness and Natural Resources Occupations. Agricultural Resources Component. A Report of Research.

ERIC Educational Resources Information Center

Cheek, Jimmy G.; McGhee, Max B.

An activity was undertaken to develop written criterion-referenced tests for the agricultural resources component of Applied Principles of Agribusiness and Natural Resources. Intended for tenth grade students who have completed Fundamentals of Agribusiness and Natural Resources Occupations, applied principles were designed to consist of three…

Competency Test Items for Applied Principles of Agribusiness and Natural Resources Occupations. Agricultural Production Component. A Report of Research.

ERIC Educational Resources Information Center

Cheek, Jimmy G.; McGhee, Max B.

An activity was undertaken to develop written criterion-referenced tests for the agricultural production component of Applied Principles of Agribusiness and Natural Resources Occupations. Intended for tenth grade students who have completed Fundamentals of Agribusiness and Natural Resources Occupations, applied principles were designed to consist…

Active control of fan noise from a turbofan engine

NASA Technical Reports Server (NTRS)

Thomas, Russell H.; Burdisso, Ricardo A.; Fuller, Christopher R.; O'Brien, Walter F.

1993-01-01

A three channel active control system is applied to an operational turbofan engine in order to reduce tonal noise produced by both the fan and high pressure compressor. The control approach is the feedforward filtered-x least-mean-square algorithm implemented on a digital signal processing board. Reference transducers mounted on the engine case provides blade passing and harmonics frequency information to the controller. Error information is provided by large area microphones placed in the acoustic far field. In order to minimize the error signal, the controller actuates loudspeakers mounted on the inlet to produce destructive interference. The sound pressure level of the fundamental tone of the fan was reduced using the three channel controller by up to 16 dB over a 60 deg angle about the engine axis. A single channel controller could produce reduction over a 30 deg angle. The experimental results show the control to be robust. Simultaneous control of two tones is done with parallel controllers. The fundamental and the first harmonic tones of the fan were controlled simultaneously with reductions of 12 dBA and 5 dBA, respectively, measured on the engine axis. Simultaneous control was also demonstrated for the fan fundamental and the high pressure compressor fundamental tones.

Water Balance Covers For Waste Containment: Principles and Practice

EPA Science Inventory

Water Balance Covers for Waste Containment: Principles and Practices introduces water balance covers and compares them with conventional approaches to waste containment. The authors provided detailed analysis of the fundamentals of soil physics and design issues, introduce appl...

Chemical Risk Assessment

EPA Science Inventory

This course is aimed at providing an overview of the fundamental guiding principles and general methods used in chemical risk assessment. Chemical risk assessment is a complex and ever-evolving process. These principles and methods have been organized by the National Research Cou...

Enhancement of Teaching and Learning of the Fundamentals of Nuclear Engineering Using Multimedia Courseware.

ERIC Educational Resources Information Center

Keyvan, Shahla A.; Pickard, Rodney; Song, Xiaolong

1997-01-01

Computer-aided instruction incorporating interactive multimedia and network technologies can boost teaching effectiveness and student learning. This article describes the development and implementation of network server-based interactive multimedia courseware for a fundamental course in nuclear engineering. A student survey determined that 80% of…

Engine Fundamentals: Automotive Mechanics Instructional Program. Block 2.

ERIC Educational Resources Information Center

O'Brien, Ralph D.

The second of six instructional blocks in automotive mechanics, the lessons and supportive information in the document provide a guide for teachers in planning an instructional program in engine fundamentals at the secondary and postsecondary level. The material, as organized, is a suggested sequence of instruction within each block. Each lesson…

22 CFR 120.11 - Public domain.

Code of Federal Regulations, 2012 CFR

2012-04-01

... libraries open to the public or from which the public can obtain documents; (5) Through patents available at... fundamental research in science and engineering at accredited institutions of higher learning in the U.S.... Fundamental research is defined to mean basic and applied research in science and engineering where the...

22 CFR 120.11 - Public domain.

Code of Federal Regulations, 2014 CFR

2014-04-01

... libraries open to the public or from which the public can obtain documents; (5) Through patents available at... fundamental research in science and engineering at accredited institutions of higher learning in the U.S.... Fundamental research is defined to mean basic and applied research in science and engineering where the...

22 CFR 120.11 - Public domain.

Code of Federal Regulations, 2011 CFR

2011-04-01

... libraries open to the public or from which the public can obtain documents; (5) Through patents available at... fundamental research in science and engineering at accredited institutions of higher learning in the U.S.... Fundamental research is defined to mean basic and applied research in science and engineering where the...

22 CFR 120.11 - Public domain.

Code of Federal Regulations, 2013 CFR

2013-04-01

... libraries open to the public or from which the public can obtain documents; (5) Through patents available at... fundamental research in science and engineering at accredited institutions of higher learning in the U.S.... Fundamental research is defined to mean basic and applied research in science and engineering where the...

Rocket propulsion elements - An introduction to the engineering of rockets (6th revised and enlarged edition)

NASA Astrophysics Data System (ADS)

Sutton, George P.

The subject of rocket propulsion is treated with emphasis on the basic technology, performance, and design rationale. Attention is given to definitions and fundamentals, nozzle theory and thermodynamic relations, heat transfer, flight performance, chemical rocket propellant performance analysis, and liquid propellant rocket engine fundamentals. The discussion also covers solid propellant rocket fundamentals, hybrid propellant rockets, thrust vector control, selection of rocket propulsion systems, electric propulsion, and rocket testing.

A Model to Measure Bombardier/Navigator Performance during Radar Navigation in Device 2F114, A-6E Weapon System Trainer.

DTIC Science & Technology

1981-03-01

systems, sub- systems, equipment, weapons, tactics, missions, etc. Concepts and Principles - Fundamental truths, ideas, opinions and thoughts formed from...verification, etc. Grasping the meaning of concepts and principles , i.e., understanding the basic principles of infrared and radar detection. Understanding...concepts, principles , procedures, etc.). Analysis A demonstration of a learned process of breaking down material (i.e., data, other information) into

Fundamental electrode kinetics

NASA Technical Reports Server (NTRS)

Elder, J. P.

1968-01-01

Report presents the fundamentals of electrode kinetics and the methods used in evaluating the characteristic parameters of rapid-charge transfer processes at electrode-electrolyte interfaces. The concept of electrode kinetics is outlined, followed by the principles underlying the experimental techniques for the investigation of electrode kinetics.

A CAL Program to Teach the Basic Principles of Genetic Engineering--A Change from the Traditional Approach.

ERIC Educational Resources Information Center

Dewhurst, D. G.; And Others

1989-01-01

An interactive computer-assisted learning program written for the BBC microcomputer to teach the basic principles of genetic engineering is described. Discussed are the hardware requirements software, use of the program, and assessment. (Author/CW)

Fuel cells: principles, types, fuels, and applications.

PubMed

Carrette, L; Friedrich, K A; Stimming, U

2000-12-15

During the last decade, fuel cells have received enormous attention from research institutions and companies as novel electrical energy conversion systems. In the near future, they will see application in automotive propulsion, distributed power generation, and in low power portable devices (battery replacement). This review gives an introduction into the fundamentals and applications of fuel cells: Firstly, the environmental and social factors promoting fuel cell development are discussed, with an emphasis on the advantages of fuel cells compared to the conventional techniques. Then, the main reactions, which are responsible for the conversion of chemical into electrical energy in fuel cells, are given and the thermodynamic and kinetic fundamentals are stated. The theoretical and real efficiencies of fuel cells are also compared to that of internal combustion engines. Next, the different types of fuel cells and their main components are explained and the related material issues are presented. A section is devoted to fuel generation and storage, which is of paramount importance for the practical aspects of fuel cell use. Finally, attention is given to the integration of the fuel cells into complete systems. © 2000 WILEY-VCH Verlag GmbH, Weinheim, Fed. Rep. of Germany.

Global challenges as inspiration: a classroom strategy to foster social responsibility.

PubMed

Vanasupa, Linda; Slivovsky, Lynn; Chen, Katherine C

2006-04-01

Social responsibility is at the heart of the Engineer's Creed embodied in the pledge that we will dedicate [our] professional knowledge and skill to the advancement and betterment of human welfare... [placing] public welfare above all other considerations. However, half century after the original creed was written, we find ourselves in a world with great technological advances and great global-scale technologically-enabled peril. These issues can be naturally integrated into the engineering curriculum in a way that enhances the development of the technological skill set. We have found that these global challenges create a natural opportunity to foster social responsibility within the engineering students whom we educate. In freshman through senior-level materials engineering courses, we used five guiding principles to shape several different classroom activities and assignments. Upon testing an initial cohort of 28 students had classroom experiences based on these five principles, we saw a shift in attitude: before the experience, 18% of the cohort viewed engineers as playing an active role in solving global problems; after the experiences, 79% recognized the engineer's role in solving global-scale problems. In this paper, we present how global issues can be used to stimulate thinking for socially-responsible engineering solutions. We set forth five guiding principles that can foster the mindset for socially responsible actions along with examples of how these principles translate into classroom activities.

Personality Theories Facilitate Integrating the Five Principles and Deducing Hypotheses for Testing

ERIC Educational Resources Information Center

Maddi, Salvatore R.

2007-01-01

Comments on the original article "A New Big Five: Fundamental Principles for an Integrative Science of Personality," by Dan P. McAdams and Jennifer L. Pals (see record 2006-03947-002). In presenting their view of personality science, McAdams and Pals (April 2006) elaborated the importance of five principles for building an integrated science of…

Technology transfer in software engineering

NASA Technical Reports Server (NTRS)

Bishop, Peter C.

1989-01-01

The University of Houston-Clear Lake is the prime contractor for the AdaNET Research Project under the direction of NASA Johnson Space Center. AdaNET was established to promote the principles of software engineering to the software development industry. AdaNET will contain not only environments and tools, but also concepts, principles, models, standards, guidelines and practices. Initially, AdaNET will serve clients from the U.S. government and private industry who are working in software development. It will seek new clients from those who have not yet adopted the principles and practices of software engineering. Some of the goals of AdaNET are to become known as an objective, authoritative source of new software engineering information and parts, to provide easy access to information and parts, and to keep abreast of innovations in the field.

Lessons Learned in Engineering. Supplement

NASA Technical Reports Server (NTRS)

Blair, James C.; Ryan, Robert S.; Schultzenhofer, Luke A.

2011-01-01

This Contractor Report (CR) is a compilation of Lessons Learned in approximately 55 years of engineering experience by each James C. Blair, Robert S. Ryan, and Luke A. Schutzenhofer. The lessons are the basis of a course on Lessons Learned that has been taught at Marshall Space Flight Center. The lessons are drawn from NASA space projects and are characterized in terms of generic lessons learned from the project experience, which are further distilled into overarching principles that can be applied to future projects. Included are discussions of the overarching principles followed by a listing of the lessons associated with that principle. The lesson with sub-lessons are stated along with a listing of the project problems the lesson is drawn from, then each problem is illustrated and discussed, with conclusions drawn in terms of Lessons Learned. The purpose of this CR is to provide principles learned from past aerospace experience to help achieve greater success in future programs, and identify application of these principles to space systems design. The problems experienced provide insight into the engineering process and are examples of the subtleties one experiences performing engineering design, manufacturing, and operations. The supplemental CD contains accompanying PowerPoint presentations.

Mechanical-Kinetic Modeling of a Molecular Walker from a Modular Design Principle

NASA Astrophysics Data System (ADS)

Hou, Ruizheng; Loh, Iong Ying; Li, Hongrong; Wang, Zhisong

2017-02-01

Artificial molecular walkers beyond burnt-bridge designs are complex nanomachines that potentially replicate biological walkers in mechanisms and functionalities. Improving the man-made walkers up to performance for widespread applications remains difficult, largely because their biomimetic design principles involve entangled kinetic and mechanical effects to complicate the link between a walker's construction and ultimate performance. Here, a synergic mechanical-kinetic model is developed for a recently reported DNA bipedal walker, which is based on a modular design principle, potentially enabling many directional walkers driven by a length-switching engine. The model reproduces the experimental data of the walker, and identifies its performance-limiting factors. The model also captures features common to the underlying design principle, including counterintuitive performance-construction relations that are explained by detailed balance, entropy production, and bias cancellation. While indicating a low directional fidelity for the present walker, the model suggests the possibility of improving the fidelity above 90% by a more powerful engine, which may be an improved version of the present engine or an entirely new engine motif, thanks to the flexible design principle. The model is readily adaptable to aid these experimental developments towards high-performance molecular walkers.

Biomimetic design processes in architecture: morphogenetic and evolutionary computational design.

PubMed

Menges, Achim

2012-03-01

Design computation has profound impact on architectural design methods. This paper explains how computational design enables the development of biomimetic design processes specific to architecture, and how they need to be significantly different from established biomimetic processes in engineering disciplines. The paper first explains the fundamental difference between computer-aided and computational design in architecture, as the understanding of this distinction is of critical importance for the research presented. Thereafter, the conceptual relation and possible transfer of principles from natural morphogenesis to design computation are introduced and the related developments of generative, feature-based, constraint-based, process-based and feedback-based computational design methods are presented. This morphogenetic design research is then related to exploratory evolutionary computation, followed by the presentation of two case studies focusing on the exemplary development of spatial envelope morphologies and urban block morphologies.

Unexpected large nanoparticle size of single dimer hotspot systems for broadband SERS enhancement.

PubMed

Huang, Yu; Chen, Yun; Xue, Xiaotian; Zhai, Yanni; Wang, Lingling; Zhang, Zhengjun

2018-05-15

We have numerically demonstrated the feasibility and possibility to achieve broadband surface-enhanced Raman scattering (SERS) enhancement in the visible and near-infrared wavelength range using single nanoparticle (NP) dimer hotspot systems. Instead of the conventionally reported sub-100 nm, we find that the optimal NP size is as large as 200 nm in diameter for both Ag and Au. The key lies in the continuous arising of the bonding dipole plasmon mode and higher-order resonances at shorter wavelengths. Further, it is revealed that the near- and far-field optical responses of these hotspot systems correlate well with each other, despite the intrinsic enormous near- to far-field redshift for individual large NPs. The physical principles demonstrated here benefit significantly the fundamental understanding and engineering optimization of broadband SERS substrates.

Brackets, epitopes and flash memory cards: a futuristic view of clinical orthodontics.

PubMed

Sims, Milton R

2017-02-01

Orthodontics continues to be a profession anchored in traditional technology using appliances that cause inflammatory periodontal ligament (PDL) responses. Existing concepts of biological tooth movement based largely on histological tissue observations and the application of physical principles require major reassessment. In the next millennium, the genome revolution and knowledge of protein production and control could lead to the genetic correction of dentofacial anomalies and pain-free, biomolecular methods of malocclusion correction and long-term stability. A fundamental change is likely to be the abolition of bracket systems and their replacement with preprogrammed microchips driven by computers, and the control of PD[ blood vessels and cells by pharmacological targeting. Future survival of the profession will depend on a radically different specialist who will be educated with a postgraduate curriculum based on molecular biology and computer engineering.

Variation principle in calculating the flow of a two-phase mixture in the pipes of the cooling systems in high-rise buildings

NASA Astrophysics Data System (ADS)

Aksenov, Andrey; Malysheva, Anna

2018-03-01

The analytical solution of one of the urgent problems of modern hydromechanics and heat engineering about the distribution of gas and liquid phases along the channel cross-section, the thickness of the annular layer and their connection with the mass content of the gas phase in the gas-liquid flow is given in the paper.The analytical method is based on the fundamental laws of theoretical mechanics and thermophysics on the minimum of energy dissipation and the minimum rate of increase in the system entropy, which determine the stability of stationary states and processes. Obtained dependencies disclose the physical laws of the motion of two-phase media and can be used in hydraulic calculations during the design and operation of refrigeration and air conditioning systems.

Training of Engineering Personnel for the Innovative Coal Industry: Problems and Ways of Solution

NASA Astrophysics Data System (ADS)

Zaruba, Natalya; Fraltsova, Tamara; Snegireva, Tatyana

2017-11-01

The article is written based on some results of the long-term scientific research of the problem related to the urgent need to find the ways of training personnel for the innovative coal industry in the higher education system. This is due to the fundamental changes in the Russian social and economic conditions: the change in the social system and the owner of the coal industry, the emergence of new technologies in the field of coal mining and processing, and in the management of these processes. At the same time, the system of training specialists for the coal industry in the higher education institutions has largely remained unchanged: technologies and principles of training, scientific approaches and concepts take little account of the changed situation, traditional views of specialists work-ing in the university continue to dominate innovative ideas. Many innovations, especially related to technology and the principles of education, struggle to make their way into the higher education system. The article substantiates the urgency of the problem of training personnel for the innovative coal industry in the higher education system, as well as the importance of scientific analysis of the problem in order to find the ways to solve it.

Fundamental heat transfer research for gas turbine engines

NASA Technical Reports Server (NTRS)

Metzger, D. E. (Editor)

1980-01-01

Thirty-seven experts from industry and the universities joined 24 NASA Lewis staff members in an exchange of ideas on trends in aeropropulsion research and technology, basic analyses, computational analyses, basic experiments, near-engine environment experiments, fundamental fluid mechanics and heat transfer, and hot technology as related to gas turbine engines. The workshop proceedings described include pre-workshop input from participants, presentations of current activity by the Lewis staff, reports of the four working groups, and a workshop summary.

Evolutionary principles and their practical application

PubMed Central

Hendry, Andrew P; Kinnison, Michael T; Heino, Mikko; Day, Troy; Smith, Thomas B; Fitt, Gary; Bergstrom, Carl T; Oakeshott, John; Jørgensen, Peter S; Zalucki, Myron P; Gilchrist, George; Southerton, Simon; Sih, Andrew; Strauss, Sharon; Denison, Robert F; Carroll, Scott P

2011-01-01

Evolutionary principles are now routinely incorporated into medicine and agriculture. Examples include the design of treatments that slow the evolution of resistance by weeds, pests, and pathogens, and the design of breeding programs that maximize crop yield or quality. Evolutionary principles are also increasingly incorporated into conservation biology, natural resource management, and environmental science. Examples include the protection of small and isolated populations from inbreeding depression, the identification of key traits involved in adaptation to climate change, the design of harvesting regimes that minimize unwanted life-history evolution, and the setting of conservation priorities based on populations, species, or communities that harbor the greatest evolutionary diversity and potential. The adoption of evolutionary principles has proceeded somewhat independently in these different fields, even though the underlying fundamental concepts are the same. We explore these fundamental concepts under four main themes: variation, selection, connectivity, and eco-evolutionary dynamics. Within each theme, we present several key evolutionary principles and illustrate their use in addressing applied problems. We hope that the resulting primer of evolutionary concepts and their practical utility helps to advance a unified multidisciplinary field of applied evolutionary biology. PMID:25567966

Evolutionary principles and their practical application.

PubMed

Hendry, Andrew P; Kinnison, Michael T; Heino, Mikko; Day, Troy; Smith, Thomas B; Fitt, Gary; Bergstrom, Carl T; Oakeshott, John; Jørgensen, Peter S; Zalucki, Myron P; Gilchrist, George; Southerton, Simon; Sih, Andrew; Strauss, Sharon; Denison, Robert F; Carroll, Scott P

2011-03-01

Evolutionary principles are now routinely incorporated into medicine and agriculture. Examples include the design of treatments that slow the evolution of resistance by weeds, pests, and pathogens, and the design of breeding programs that maximize crop yield or quality. Evolutionary principles are also increasingly incorporated into conservation biology, natural resource management, and environmental science. Examples include the protection of small and isolated populations from inbreeding depression, the identification of key traits involved in adaptation to climate change, the design of harvesting regimes that minimize unwanted life-history evolution, and the setting of conservation priorities based on populations, species, or communities that harbor the greatest evolutionary diversity and potential. The adoption of evolutionary principles has proceeded somewhat independently in these different fields, even though the underlying fundamental concepts are the same. We explore these fundamental concepts under four main themes: variation, selection, connectivity, and eco-evolutionary dynamics. Within each theme, we present several key evolutionary principles and illustrate their use in addressing applied problems. We hope that the resulting primer of evolutionary concepts and their practical utility helps to advance a unified multidisciplinary field of applied evolutionary biology.

Why Science?

ERIC Educational Resources Information Center

Trefil, James

2007-01-01

Prize-winning scientist and bestselling author James Trefil explains why every U.S. citizen needs to be "scientifically literate" and, therefore, why schools must teach the fundamental principles of scientific literacy to every student. He lays out those principles straightforwardly, so that educators--and everyone who is interested in…

Preparation for Careers--Not Jobs

ERIC Educational Resources Information Center

Worthy, James C.

1977-01-01

Sangamon State University's experimental management program has demonstrated the fundamental soundness of the generic approach. Application of common principles to a variety of organizational situations contributes to a better understanding of those principles and helps students understand the differences between organizations and how to adapt to…

Water System Adaptation To Hydrological Changes: Module 7, Adaptation Principles and Considerations

EPA Science Inventory

This course will introduce students to the fundamental principles of water system adaptation to hydrological changes, with emphasis on data analysis and interpretation, technical planning, and computational modeling. Starting with real-world scenarios and adaptation needs, the co...

The new genetic technologies: why a theological perspective is necessary.

PubMed

Engelhardt, H Tristram

2003-01-01

Secular bioethics poses questions that can be recognized as important, though it lacks the resources to answer them. Secular bioethics may retain the sense that there should be moral limits to the use of germline genetic engineering, but it lacks the basis to justify limits in principle. The contemporary practice of bioethics arose in the United States to fill a moral vacuum created by (1) the marginalization of medical ethics through the deprofessionalization of medicine, (2) the secularization of American society, and (3) an increased reliance on individual decision-making. The result is an ethics at the core of secular bioethics severed from a sense of ultimate purpose or direction for humans or the cosmos. This ethics and its bioethics are marked by (1) moral fragmentation and pluralism and (2) a loss of ultimate orientation. This bioethics can at best require (1) the prudent maximization of benefits over harms, (2) the condemnation of malevolent acts, and (3) the use of persons only with their consent. However, there fails to be a basis for a common view of benefit or of harm. Within this impoverished moral context, human biological nature can only appear to be a contingent outcome of spontaneous mutations, selective pressure, the constraints of physical laws, and random catastrophes. Such a bioethics, deprived of ultimate orientation, can provide no ground in principle for forbidding cloning, germline genetic engineering, or the fundamental recasting of human nature. Absent a theological point of orientation, medicine and the genetic technology are left with more power than ever but no clear moral sense of how to use that power.

Engineering Encounters: Teaching Educators about Engineering

ERIC Educational Resources Information Center

Tank, Kristina M.; Raman, D. Raj; Lamm, Monica H.; Sundararajan, Sriram; Estapa, Anne

2017-01-01

This column presents ideas and techniques to enhance science teaching. This month's issue describes preservice elementary teachers learning engineering principles from engineers. Few elementary teachers have experience with implementing engineering into the classroom. While engineering professional development opportunities for inservice teachers…

Software Engineering Principles for Courseware Development.

ERIC Educational Resources Information Center

Magel, Kenneth

1980-01-01

Courseware (computer based curriculum materials) development should follow the lessons learned by software engineers. The most important of 28 principles of software development presented here include a stress on human readability, the importance of early planning and analysis, the need for independent evaluation, and the need to be flexible.…

Functional groups of ecosystem engineers: a proposed classification with comments on current issues.

PubMed

Berke, Sarah K

2010-08-01

Ecologists have long known that certain organisms fundamentally modify, create, or define habitats by altering the habitat's physical properties. In the past 15 years, these processes have been formally defined as "ecosystem engineering", reflecting a growing consensus that environmental structuring by organisms represents a fundamental class of ecological interactions occurring in most, if not all, ecosystems. Yet, the precise definition and scope of ecosystem engineering remains debated, as one should expect given the complexity, enormity, and variability of ecological systems. Here I briefly comment on a few specific current points of contention in the ecosystem engineering concept. I then suggest that ecosystem engineering can be profitably subdivided into four narrower functional categories reflecting four broad mechanisms by which ecosystem engineering occurs: structural engineers, bioturbators, chemical engineers, and light engineers. Finally, I suggest some conceptual model frameworks that could apply broadly within these functional groups.

Basic Electronics I.

ERIC Educational Resources Information Center

Robertson, L. Paul

Designed for use in basic electronics programs, this curriculum guide is comprised of twenty-nine units of instruction in five major content areas: Orientation, Basic Principles of Electricity/Electronics, Fundamentals of Direct Current, Fundamentals of Alternating Current, and Applying for a Job. Each instructional unit includes some or all of…

Variation of fundamental constants on sub- and super-Hubble scales: From the equivalence principle to the multiverse

NASA Astrophysics Data System (ADS)

Uzan, Jean-Philippe

2013-02-01

Fundamental constants play a central role in many modern developments in gravitation and cosmology. Most extensions of general relativity lead to the conclusion that dimensionless constants are actually dynamical fields. Any detection of their variation on sub-Hubble scales would signal a violation of the Einstein equivalence principle and hence a lead to gravity beyond general relativity. On super-Hubble scales, or maybe should we say on super-universe scales, such variations are invoked as a solution to the fine-tuning problem, in connection with an anthropic approach.

Guiding Principles for Student Leadership Development in the Doctor of Pharmacy Program to Assist Administrators and Faculty Members in Implementing or Refining Curricula

PubMed Central

Boyle, Cynthia J.; Janke, Kristin K.

2013-01-01

Objective. To assist administrators and faculty members in colleges and schools of pharmacy by gathering expert opinion to frame, direct, and support investments in student leadership development. Methods. Twenty-six leadership instructors participated in a 3-round, online, modified Delphi process to define doctor of pharmacy (PharmD) student leadership instruction. Round 1 asked open-ended questions about leadership knowledge, skills, and attitudes to begin the generation of student leadership development guiding principles and competencies. Statements were identified as guiding principles when they were perceived as foundational to the instructional approach. Round 2 grouped responses for agreement rating and comment. Group consensus with a statement as a guiding principle was set prospectively at 80%. Round 3 allowed rating and comment on guidelines, modified from feedback in round 2, that did not meet consensus. The principles were verified by identifying common contemporary leadership development approaches in the literature. Results. Twelve guiding principles, related to concepts of leadership and educational philosophy, were defined and could be linked to contemporary leadership development thought. These guiding principles describe the motivation for teaching leadership, the fundamental precepts of student leadership development, and the core tenets for leadership instruction. Conclusions. Expert opinion gathered using a Delphi process resulted in guiding principles that help to address many of the fundamental questions that arise when implementing or refining leadership curricula. The principles identified are supported by common contemporary leadership development thought. PMID:24371345

Guiding principles for student leadership development in the doctor of pharmacy program to assist administrators and faculty members in implementing or refining curricula.

PubMed

Traynor, Andrew P; Boyle, Cynthia J; Janke, Kristin K

2013-12-16

To assist administrators and faculty members in colleges and schools of pharmacy by gathering expert opinion to frame, direct, and support investments in student leadership development. Twenty-six leadership instructors participated in a 3-round, online, modified Delphi process to define doctor of pharmacy (PharmD) student leadership instruction. Round 1 asked open-ended questions about leadership knowledge, skills, and attitudes to begin the generation of student leadership development guiding principles and competencies. Statements were identified as guiding principles when they were perceived as foundational to the instructional approach. Round 2 grouped responses for agreement rating and comment. Group consensus with a statement as a guiding principle was set prospectively at 80%. Round 3 allowed rating and comment on guidelines, modified from feedback in round 2, that did not meet consensus. The principles were verified by identifying common contemporary leadership development approaches in the literature. Twelve guiding principles, related to concepts of leadership and educational philosophy, were defined and could be linked to contemporary leadership development thought. These guiding principles describe the motivation for teaching leadership, the fundamental precepts of student leadership development, and the core tenets for leadership instruction. Expert opinion gathered using a Delphi process resulted in guiding principles that help to address many of the fundamental questions that arise when implementing or refining leadership curricula. The principles identified are supported by common contemporary leadership development thought.

Framework for non-coherent interface models at finite displacement jumps and finite strains

NASA Astrophysics Data System (ADS)

Ottosen, Niels Saabye; Ristinmaa, Matti; Mosler, Jörn

2016-05-01

This paper deals with a novel constitutive framework suitable for non-coherent interfaces, such as cracks, undergoing large deformations in a geometrically exact setting. For this type of interface, the displacement field shows a jump across the interface. Within the engineering community, so-called cohesive zone models are frequently applied in order to describe non-coherent interfaces. However, for existing models to comply with the restrictions imposed by (a) thermodynamical consistency (e.g., the second law of thermodynamics), (b) balance equations (in particular, balance of angular momentum) and (c) material frame indifference, these models are essentially fiber models, i.e. models where the traction vector is collinear with the displacement jump. This constraints the ability to model shear and, in addition, anisotropic effects are excluded. A novel, extended constitutive framework which is consistent with the above mentioned fundamental physical principles is elaborated in this paper. In addition to the classical tractions associated with a cohesive zone model, the main idea is to consider additional tractions related to membrane-like forces and out-of-plane shear forces acting within the interface. For zero displacement jump, i.e. coherent interfaces, this framework degenerates to existing formulations presented in the literature. For hyperelasticity, the Helmholtz energy of the proposed novel framework depends on the displacement jump as well as on the tangent vectors of the interface with respect to the current configuration - or equivalently - the Helmholtz energy depends on the displacement jump and the surface deformation gradient. It turns out that by defining the Helmholtz energy in terms of the invariants of these variables, all above-mentioned fundamental physical principles are automatically fulfilled. Extensions of the novel framework necessary for material degradation (damage) and plasticity are also covered.

Beyond the Virtues-Principles Debate.

ERIC Educational Resources Information Center

Keat, Marilyn S.

1992-01-01

Indicates basic ontological assumptions in the virtues-principles debate in moral philosophy, noting Aristotle's and Kant's fundamental ideas about morality and considering a hermeneutic synthesis of theories. The article discusses what acceptance of the synthesis might mean in the theory and practice of moral pedagogy, offering examples of…

Linguistic Recycling and the Open Community.

ERIC Educational Resources Information Center

Dasgupta, Probal

2001-01-01

Examines linguistic recycling in the context of domestic Esperanto use. Argues that word-meaning recycling reflects the same fundamental principles as sentential recursion, and that a linguistics theoretically sensitive to these principles strengthens practical efforts towards the social goal of an open speech community. (Author/VWL)

An Introduction to the Fundamentals of Chemistry for the Marine Engineer - An Audio-Tutorial Correspondence Course (CH-1C).

ERIC Educational Resources Information Center

Schlenker, Richard M.

This document provides a study guide for a three-credit-hour fundamentals of chemistry course for marine engineer majors. The course is composed of 17 minicourses including: chemical reactions, atomic theory, solutions, corrosion, organic chemistry, water pollution, metric system, and remedial mathematics skills. Course grading, objectives,…

Selected topics of fluid mechanics

USGS Publications Warehouse

Kindsvater, Carl E.

1958-01-01

The fundamental equations of fluid mechanics are specific expressions of the principles of motion which are ascribed to Isaac Newton. Thus, the equations which form the framework of applied fluid mechanics or hydraulics are, in addition to the equation of continuity, the Newtonian equations of energy and momentum. These basic relationships are also the foundations of river hydraulics. The fundamental equations are developed in this report with sufficient rigor to support critical examinations of their applicability to most problems met by hydraulic engineers of the Water Resources Division of the United States Geological Survey. Physical concepts are emphasized, and mathematical procedures are the simplest consistent with the specific requirements of the derivations. In lieu of numerical examples, analogies, and alternative procedures, this treatment stresses a brief methodical exposition of the essential principles. An important objective of this report is to prepare the user to read the literature of the science. Thus, it begins With a basic vocabulary of technical symbols, terms, and concepts. Throughout, emphasis is placed on the language of modern fluid mechanics as it pertains to hydraulic engineering. The basic differential and integral equations of simple fluid motion are derived, and these equations are, in turn, used to describe the essential characteristics of hydrostatics and piezometry. The one-dimensional equations of continuity and motion are defined and are used to derive the general discharge equation. The flow net is described as a means of demonstrating significant characteristics of two-dimensional irrotational flow patterns. A typical flow net is examined in detail. The influence of fluid viscosity is described as an obstacle to the derivation of general, integral equations of motion. It is observed that the part played by viscosity is one which is usually dependent on experimental evaluation. It follows that the dimensionless ratios known as the Euler, Froude, Reynolds, Weber, and Cauchy numbers are defined as essential tools for interpreting and using experimental data. The derivations of the energy and momentum equations are treated in detail. One-dimensional equations for steady nonuniform flow are developed, and the restrictions applicable to the equations are emphasized. Conditions of uniform and gradually varied flow are discussed, and the origin of the Chezy equation is examined in relation to both the energy and the momentum equations. The inadequacy of all uniform-flow equations as a means of describing gradually varied flow is explained. Thus, one of the definitive problems of river hydraulics is analyzed in the light of present knowledge. This report is the outgrowth of a series of short schools conducted during the spring and summer of 1953 for engineers of the Surface Water Branch, Water Resources Division, U. S. Geological Survey. The topics considered are essentially the same as the topics selected for inclusion in the schools. However, in order that they might serve better as a guide and outline for informal study, the arrangement of the writer's original lecture notes has been considerably altered. The purpose of the report, like the purpose of the schools which inspired it, is to build a simple but strong framework of the fundamentals of fluid mechanics. It is believed that this framework is capable of supporting a detailed analysis of most of the practical problems met by the engineers of the Geological Survey. It is hoped that the least accomplishment of this work will be to inspire the reader with the confidence and desire to read more of the recent and current technical literature of modern fluid mechanics.

SENSE IT: Student Enabled Network of Sensors for the Environment using Innovative Technology

NASA Astrophysics Data System (ADS)

Hotaling, L. A.; Stolkin, R.; Kirkey, W.; Bonner, J. S.; Lowes, S.; Lin, P.; Ojo, T.

2010-12-01

SENSE IT is a project funded by the National Science Foundation (NSF) which strives to enrich science, technology, engineering and mathematics (STEM) education by providing teacher professional development and classroom projects in which high school students build from first principles, program, test and deploy sensors for water quality monitoring. Sensor development is a broad and interdisciplinary area, providing motivating scenarios in which to teach a multitude of STEM subjects, from mathematics and physics to biology and environmental science, while engaging students with hands on problems that reinforce conventional classroom learning by re-presenting theory as practical tools for building real-life working devices. The SENSE IT program is currently developing and implementing a set of high school educational modules which teach environmental science and basic engineering through the lens of fundamental STEM principles, at the same time introducing students to a new set of technologies that are increasingly important in the world of environmental research. Specifically, the project provides students with the opportunity to learn the engineering design process through the design, construction, programming and testing of a student-implemented water monitoring network in the Hudson and St. Lawrence Rivers in New York. These educational modules are aligned to state and national technology and science content standards and are designed to be compatible with standard classroom curricula to support a variety of core science, technology and mathematics classroom material. For example, while designing, programming and calibrating the sensors, the students are led through a series of tasks in which they must use core mathematics and physics theory to solve the real problems of making their sensors work. In later modules, students can explore environmental science and environmental engineering curricula while deploying and monitoring their sensors in local rivers. This presentation will provide an overview of the educational modules. A variety of sensors will be described, which are suitably simple for design and construction from first principles by high school students while being accurate enough for students to make meaningful environmental measurements. The presentation will also describe how the sensor building activities can be tied to core curricula classroom theory, enabling the modules to be utilized in regular classes by mathematics, science and computing teachers without disrupting their semester’s teaching goals. Furthermore, the presentation will address of the first two years of the SENSE IT project, during which 39 teachers have been equipped, trained on these materials, and have implemented the modules with around approximately 2,000 high school students.

Space Shuttle Main Engine performance analysis

NASA Technical Reports Server (NTRS)

Santi, L. Michael

1993-01-01

For a number of years, NASA has relied primarily upon periodically updated versions of Rocketdyne's power balance model (PBM) to provide space shuttle main engine (SSME) steady-state performance prediction. A recent computational study indicated that PBM predictions do not satisfy fundamental energy conservation principles. More recently, SSME test results provided by the Technology Test Bed (TTB) program have indicated significant discrepancies between PBM flow and temperature predictions and TTB observations. Results of these investigations have diminished confidence in the predictions provided by PBM, and motivated the development of new computational tools for supporting SSME performance analysis. A multivariate least squares regression algorithm was developed and implemented during this effort in order to efficiently characterize TTB data. This procedure, called the 'gains model,' was used to approximate the variation of SSME performance parameters such as flow rate, pressure, temperature, speed, and assorted hardware characteristics in terms of six assumed independent influences. These six influences were engine power level, mixture ratio, fuel inlet pressure and temperature, and oxidizer inlet pressure and temperature. A BFGS optimization algorithm provided the base procedure for determining regression coefficients for both linear and full quadratic approximations of parameter variation. Statistical information relative to data deviation from regression derived relations was also computed. A new strategy for integrating test data with theoretical performance prediction was also investigated. The current integration procedure employed by PBM treats test data as pristine and adjusts hardware characteristics in a heuristic manner to achieve engine balance. Within PBM, this integration procedure is called 'data reduction.' By contrast, the new data integration procedure, termed 'reconciliation,' uses mathematical optimization techniques, and requires both measurement and balance uncertainty estimates. The reconciler attempts to select operational parameters that minimize the difference between theoretical prediction and observation. Selected values are further constrained to fall within measurement uncertainty limits and to satisfy fundamental physical relations (mass conservation, energy conservation, pressure drop relations, etc.) within uncertainty estimates for all SSME subsystems. The parameter selection problem described above is a traditional nonlinear programming problem. The reconciler employs a mixed penalty method to determine optimum values of SSME operating parameters associated with this problem formulation.

Research approach to teaching groundwater biodegradation in karst aquifers

USGS Publications Warehouse

King, L.; Byl, T.; Painter, R.

2006-01-01

TSU in partnership with the USGS has conducted extensive research regarding biode??gradation of contaminants in karst aquifers. This research resulted in the development of a numerical approach to modeling biodegradation of contaminants in karst aquifers that is taught to environmental engineering students in several steps. First, environmental engineering students are taught chemical-reaction engineering principles relating to a wide variety of environmental fate and transport issues. Second, as part of TSU's engineering course curriculum, students use a non-ideal flow laboratory reactor system and run a tracer study to establish residence time distribution (RTD). Next, the students couple that formula to a first-order biodegradation rate and predict the removal of a biodegradable contaminant as a function of residence time. Following this, students are shown data collected from karst bedrock wells that suggest that karst aquifers are analogous to non-ideal flow reactors. The students are challenged to develop rates of biodegradation through lab studies and use their results to predict biodegradaton at an actual contaminated karst site. Field studies are also conducted to determine the accuracy of the students' predictions. This academic approach teaches biodegradation processes, rate-kinetic processes, hydraulic processes and numerical principles. The students are able to experience how chemical engineering principles can be applied to other situations, such as, modeling biodegradation of contaminants in karst aquifers. This paper provides background on the chemical engineering principles and karst issues used in the research-enhanced curriculum. ?? American Society for Engineering Education, 2006.

Practical Application of Sociology in Systems Engineering

NASA Technical Reports Server (NTRS)

Watson, Michael D.; Andrews, James G.; Eckley, Jeri Cassel; Culver, Michael L.

2017-01-01

Systems engineering involves both the integration of the system and the integration of the disciplines which develop and operate the system. Integrating the disciplines is a sociological effort to bring together different groups, who often have different terminology, to achieve a common goal, the system. The focus for the systems engineer is information flow through the organization, between the disciplines, to ensure the system is developed and operated will all relevant information informing system decisions. The practical application of the sociology in systems engineering brings in various organizational development concepts including the principles of planned renegotiation and the application of principles to address information barriers created by organizational culture. Concepts such as specification of ignorance, consistent terminology, opportunity structures, role-sets, and the reclama (reconsideration) process are all important sociological approaches that help address the organizational social structure (culture). In bringing the disciplines together, the systems engineer must also be wary of social ambivalence, social anomie, social dysfunction, and insider-outsider behavior. Unintended consequences can result when these social issues are present. These issues can occur when localized subcultures shift from the overarching organizational culture, or when the organizational culture prevents achievement of system goals. These sociological principles provide the systems engineer with key approaches to manage the information flow through the organization as the disciplines are integrated and share their information and provides key sociological barriers to information flow through the organization. This paper will discuss the practical application of sociological principles to systems engineering.

The Effectiveness of Contextual Learning on Physics Achievement in Career Technical Education

NASA Astrophysics Data System (ADS)

Arcand, Scott Andrew

The purpose of this casual-comparative study was to determine if students being taught the Minnesota Science Physics Standards via contextual learning methods in Project Lead the Way (PLTW) Principles of Engineering or the PLTW Aerospace Engineering courses, taught by a Career Technical Education (CTE) teacher, achieve at the same rate as students in a physics course taught by a science teacher. The PLTW courses only cover the standards taught in the first trimester of physics. The PLTW courses are two periods long for one trimester. Students who successfully pass the PLTW Principles of Engineering course or the PLTW Engineering Aerospace course earn one-half credit in physics and one-half elective credit. The instrument used to measure student achievement was the district common summative assessment for physics. The Common Summative Assessment scores were pulled from the data warehouse from the first trimester of the 2013-2014 school year. Implications of the research address concepts of contextual learning especially in the Career Technical Education space. The mean score for Physics students (30.916) and PLTW Principles of Engineering students (32.333) was not statistically significantly different. Students in PLTW Principles of Engineering achieved at the same rate as students in physics. Due to the low rate of students participating in the Common Summative Assessment in PTLW Aerospace (four out of seven students), there is not enough data to determine if there is a significant difference in the Physics A scores and PLTW Aerospace Engineering scores.

Biochemical Engineering Fundamentals

ERIC Educational Resources Information Center

Bailey, J. E.; Ollis, D. F.

1976-01-01

Discusses a biochemical engineering course that is offered as part of a chemical engineering curriculum and includes topics that influence the behavior of man-made or natural microbial or enzyme reactors. (MLH)

A review on locomotion robophysics: the study of movement at the intersection of robotics, soft matter and dynamical systems.

PubMed

Aguilar, Jeffrey; Zhang, Tingnan; Qian, Feifei; Kingsbury, Mark; McInroe, Benjamin; Mazouchova, Nicole; Li, Chen; Maladen, Ryan; Gong, Chaohui; Travers, Matt; Hatton, Ross L; Choset, Howie; Umbanhowar, Paul B; Goldman, Daniel I

2016-11-01

Discovery of fundamental principles which govern and limit effective locomotion (self-propulsion) is of intellectual interest and practical importance. Human technology has created robotic moving systems that excel in movement on and within environments of societal interest: paved roads, open air and water. However, such devices cannot yet robustly and efficiently navigate (as animals do) the enormous diversity of natural environments which might be of future interest for autonomous robots; examples include vertical surfaces like trees and cliffs, heterogeneous ground like desert rubble and brush, turbulent flows found near seashores, and deformable/flowable substrates like sand, mud and soil. In this review we argue for the creation of a physics of moving systems-a 'locomotion robophysics'-which we define as the pursuit of principles of self-generated motion. Robophysics can provide an important intellectual complement to the discipline of robotics, largely the domain of researchers from engineering and computer science. The essential idea is that we must complement the study of complex robots in complex situations with systematic study of simplified robotic devices in controlled laboratory settings and in simplified theoretical models. We must thus use the methods of physics to examine both locomotor successes and failures using parameter space exploration, systematic control, and techniques from dynamical systems. Using examples from our and others' research, we will discuss how such robophysical studies have begun to aid engineers in the creation of devices that have begun to achieve life-like locomotor abilities on and within complex environments, have inspired interesting physics questions in low dimensional dynamical systems, geometric mechanics and soft matter physics, and have been useful to develop models for biological locomotion in complex terrain. The rapidly decreasing cost of constructing robot models with easy access to significant computational power bodes well for scientists and engineers to engage in a discipline which can readily integrate experiment, theory and computation.

A review on locomotion robophysics: the study of movement at the intersection of robotics, soft matter and dynamical systems

NASA Astrophysics Data System (ADS)

Aguilar, Jeffrey; Zhang, Tingnan; Qian, Feifei; Kingsbury, Mark; McInroe, Benjamin; Mazouchova, Nicole; Li, Chen; Maladen, Ryan; Gong, Chaohui; Travers, Matt; Hatton, Ross L.; Choset, Howie; Umbanhowar, Paul B.; Goldman, Daniel I.

2016-11-01

Discovery of fundamental principles which govern and limit effective locomotion (self-propulsion) is of intellectual interest and practical importance. Human technology has created robotic moving systems that excel in movement on and within environments of societal interest: paved roads, open air and water. However, such devices cannot yet robustly and efficiently navigate (as animals do) the enormous diversity of natural environments which might be of future interest for autonomous robots; examples include vertical surfaces like trees and cliffs, heterogeneous ground like desert rubble and brush, turbulent flows found near seashores, and deformable/flowable substrates like sand, mud and soil. In this review we argue for the creation of a physics of moving systems—a ‘locomotion robophysics’—which we define as the pursuit of principles of self-generated motion. Robophysics can provide an important intellectual complement to the discipline of robotics, largely the domain of researchers from engineering and computer science. The essential idea is that we must complement the study of complex robots in complex situations with systematic study of simplified robotic devices in controlled laboratory settings and in simplified theoretical models. We must thus use the methods of physics to examine both locomotor successes and failures using parameter space exploration, systematic control, and techniques from dynamical systems. Using examples from our and others’ research, we will discuss how such robophysical studies have begun to aid engineers in the creation of devices that have begun to achieve life-like locomotor abilities on and within complex environments, have inspired interesting physics questions in low dimensional dynamical systems, geometric mechanics and soft matter physics, and have been useful to develop models for biological locomotion in complex terrain. The rapidly decreasing cost of constructing robot models with easy access to significant computational power bodes well for scientists and engineers to engage in a discipline which can readily integrate experiment, theory and computation.

Considerations on non equilibrium thermodynamics of interactions

NASA Astrophysics Data System (ADS)

Lucia, Umberto

2016-04-01

Nature can be considered the ;first; engineer! For scientists and engineers, dynamics and evolution of complex systems are not easy to predict. A fundamental approach to study complex system is thermodynamics. But, the result is the origin of too many schools of thermodynamics with a consequent difficulty in communication between thermodynamicists and other scientists and, also, among themselves. The solution is to obtain a unified approach based on the fundamentals of physics. Here we suggest a possible unification of the schools of thermodynamics starting from two fundamental concepts of physics, interaction and flows.

Lessons from the GP-B Experience for Future Fundamental Physics Missions in Space

NASA Technical Reports Server (NTRS)

Kolodziejczak, Jeffery

2006-01-01

Gravity Probe B launched in April 2004 and completed its science data collection in September 2005, with the objective of sub-milliarcsec measurement of two General Relativistic effects on the spin axis orientation of orbiting gyroscopes. Much of the technology required by GP-B has potential application in future missions intended to make precision measurements. The philosophical approach and experiment design principles developed for GP-B are equally adaptable to these mission concepts. This talk will discuss GP-B's experimental approach and the technological and philosophical lessons learned that apply to future experiments in fundamental physics. Measurement of fundamental constants to high precision, probes of short-range forces, searches for equivalence principle violations, and detection of gravitational waves are examples of concepts and missions that will benefit kern GP-B's experience.

Application of the Total Quality Management Approach Principles and the ISO 9000 Standards in Engineering Education.

ERIC Educational Resources Information Center

Waks, Shlomo; Frank, Moti

1999-01-01

Discusses the applicability of the definition, principles, and underlying strategies of total quality management (TQM) for engineering education. Describes several tools and methods for the implementation of TQM and its suitability for a variety of school activities. Presents a TQM course outline combining lectures, discussions, suggested…

Integrating Sustainable Development in Chemical Engineering Education: The Application of an Environmental Management System

ERIC Educational Resources Information Center

Montanes, M. T.; Palomares, A. E.; Sanchez-Tovar, R.

2012-01-01

The principles of sustainable development have been integrated in chemical engineering education by means of an environmental management system. These principles have been introduced in the teaching laboratories where students perform their practical classes. In this paper, the implementation of the environmental management system, the problems…

An Undergraduate Course on Operating Systems Principles.

ERIC Educational Resources Information Center

National Academy of Engineering, Washington, DC. Commission on Education.

This report is from Task Force VIII of the COSINE Committee of the Commission on Education of the National Academy of Engineering. The task force was established to formulate subject matter for an elective undergraduate subject on computer operating systems principles for students whose major interest is in the engineering of computer systems and…

DLP-based 3D metrology by structured light or projected fringe technology for life sciences and industrial metrology

NASA Astrophysics Data System (ADS)

Frankowski, G.; Hainich, R.

2009-02-01

Since the mid-eighties, a fundamental idea for achieving measuring accuracy in projected fringe technology was to consider the projected fringe pattern as an interferogram and evaluate it on the basis of advanced algorithms widely used for phase measuring in real-time interferometry. A fundamental requirement for obtaining a sufficiently high degree of measuring accuracy with this so-called "phase measuring projected fringe technology" is that the projected fringes, analogous to interference fringes, must have a cos2-shaped intensity distribution. Until the mid-nineties, this requirement for the projected fringe pattern measurement technology presented a basic handicap for its wide application in 3D metrology. This situation changed abruptly, when in the nineties Texas Instruments introduced to the market advanced digital light projection on the basis of micro mirror based projection systems, socalled DLP technology, which also facilitated the generation and projection of cos2-shaped intensity and/or fringe patterns. With this DLP technology, which from its original approach was actually oriented towards completely different applications such as multimedia projection, Texas Instruments boosted phase-measuring fringe projection in optical 3D metrology to a worldwide breakthrough both for medical as well as industrial applications. A subject matter of the lecture will be to present the fundamental principles and the resulting advantages of optical 3D metrology based on phase-measuring fringe projection using DLP technology. Further will be presented and discussed applications of the measurement technology in medical engineering and industrial metrology.

Fundamentals of microfluidic cell culture in controlled microenvironments†

PubMed Central

Young, Edmond W. K.; Beebe, David J.

2010-01-01

Microfluidics has the potential to revolutionize the way we approach cell biology research. The dimensions of microfluidic channels are well suited to the physical scale of biological cells, and the many advantages of microfluidics make it an attractive platform for new techniques in biology. One of the key benefits of microfluidics for basic biology is the ability to control parameters of the cell microenvironment at relevant length and time scales. Considerable progress has been made in the design and use of novel microfluidic devices for culturing cells and for subsequent treatment and analysis. With the recent pace of scientific discovery, it is becoming increasingly important to evaluate existing tools and techniques, and to synthesize fundamental concepts that would further improve the efficiency of biological research at the microscale. This tutorial review integrates fundamental principles from cell biology and local microenvironments with cell culture techniques and concepts in microfluidics. Culturing cells in microscale environments requires knowledge of multiple disciplines including physics, biochemistry, and engineering. We discuss basic concepts related to the physical and biochemical microenvironments of the cell, physicochemical properties of that microenvironment, cell culture techniques, and practical knowledge of microfluidic device design and operation. We also discuss the most recent advances in microfluidic cell culture and their implications on the future of the field. The goal is to guide new and interested researchers to the important areas and challenges facing the scientific community as we strive toward full integration of microfluidics with biology. PMID:20179823

Richard Day Deslattes, 21 Sept 1931 - 16 May 2001: Calibration of light, matter and fundamental constants

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chantler, C.T.

2003-01-24

Richard Deslattes passed away on 16 May 2001 after a life dedicated to fundamental metrology. Although the themes of calibrating light, matter and fundamental constants can give three guiding principles through his career, the wide-ranging nature of his areas of interest are encompassed by over 165 refereed publications with several cited over 100 times. He has left an enduring legacy to science.

Using engineering control principles to inform the design of adaptive interventions: a conceptual introduction.

PubMed

Rivera, Daniel E; Pew, Michael D; Collins, Linda M

2007-05-01

The goal of this paper is to describe the role that control engineering principles can play in developing and improving the efficacy of adaptive, time-varying interventions. It is demonstrated that adaptive interventions constitute a form of feedback control system in the context of behavioral health. Consequently, drawing from ideas in control engineering has the potential to significantly inform the analysis, design, and implementation of adaptive interventions, leading to improved adherence, better management of limited resources, a reduction of negative effects, and overall more effective interventions. This article illustrates how to express an adaptive intervention in control engineering terms, and how to use this framework in a computer simulation to investigate the anticipated impact of intervention design choices on efficacy. The potential benefits of operationalizing decision rules based on control engineering principles are particularly significant for adaptive interventions that involve multiple components or address co-morbidities, situations that pose significant challenges to conventional clinical practice.

Using Engineering Control Principles to Inform the Design of Adaptive Interventions: A Conceptual Introduction

PubMed Central

Rivera, Daniel E.; Pew, Michael D.; Collins, Linda M.

2007-01-01

The goal of this paper is to describe the role that control engineering principles can play in developing and improving the efficacy of adaptive, time-varying interventions. It is demonstrated that adaptive interventions constitute a form of feedback control system in the context of behavioral health. Consequently, drawing from ideas in control engineering has the potential to significantly inform the analysis, design, and implementation of adaptive interventions, leading to improved adherence, better management of limited resources, a reduction of negative effects, and overall more effective interventions. This article illustrates how to express an adaptive intervention in control engineering terms, and how to use this framework in a computer simulation to investigate the anticipated impact of intervention design choices on efficacy. The potential benefits of operationalizing decision rules based on control engineering principles are particularly significant for adaptive interventions that involve multiple components or address co-morbidities, situations that pose significant challenges to conventional clinical practice. PMID:17169503

Perception of Mirror Symmetry in Autism Spectrum Disorders

ERIC Educational Resources Information Center

Falter, Christine M.; Bailey, Anthony J.

2012-01-01

Gestalt grouping in autism spectrum disorders (ASD) is selectively impaired for certain organization principles but for not others. Symmetry is a fundamental Gestalt principle characterizing many biological shapes. Sensitivity to symmetry was tested using the Picture Symmetry Test, which requires finding symmetry lines on pictures. Individuals…

Basic Study on Engine with Scroll Compressor and Expander

NASA Astrophysics Data System (ADS)

Morishita, Etsuo; Kitora, Yoshihisa; Nishida, Mitsuhiro

Scroll compressors are becoming popular in air conditioning and refrigeration. This is primarily due to their higher efficiency and low noise/vibration characteristics. The scroll principle can be applied also to the steam expander and the Brayton cycle engine,as shown in the past literature. The Otto cycle spark-ignition engine with a scroll compressor and expander is studied in this report. The principle and basic structure of the scroll engine are explained,and the engine characteristic are calculated based on the idealized cycles and processes. A prototype model has been proposed and constructed. The rotary type engine has always had a problem with sealing. The scroll engine might overcome this shortcoming with its much lower rubbing speed compared to its previous counterparts,and is therefore worth investigating.

The Pursuit of Chronically Reliable Neural Interfaces: A Materials Perspective.

PubMed

Guo, Liang

2016-01-01

Brain-computer interfaces represent one of the most astonishing technologies in our era. However, the grand challenge of chronic instability and limited throughput of the electrode-tissue interface has significantly hindered the further development and ultimate deployment of such exciting technologies. A multidisciplinary research workforce has been called upon to respond to this engineering need. In this paper, I briefly review this multidisciplinary pursuit of chronically reliable neural interfaces from a materials perspective by analyzing the problem, abstracting the engineering principles, and summarizing the corresponding engineering strategies. I further draw my future perspectives by extending the proposed engineering principles.

Examining the Use of First Principles of Instruction by Instructional Designers in a Short-Term, High Volume, Rapid Production of Online K-12 Teacher Professional Development Modules

ERIC Educational Resources Information Center

Mendenhall, Anne M.

2012-01-01

Merrill (2002a) created a set of fundamental principles of instruction that can lead to effective, efficient, and engaging (e[superscript 3]) instruction. The First Principles of Instruction (Merrill, 2002a) are a prescriptive set of interrelated instructional design practices that consist of activating prior knowledge, using specific portrayals…

The Basic Principle of Calculus?

ERIC Educational Resources Information Center

Hardy, Michael

2011-01-01

A simple partial version of the Fundamental Theorem of Calculus can be presented on the first day of the first-year calculus course, and then relied upon repeatedly in assigned problems throughout the course. With that experience behind them, students can use the partial version to understand the full-fledged Fundamental Theorem, with further…

The Tractor Electrical System. A Teaching Reference.

ERIC Educational Resources Information Center

American Association for Vocational Instructional Materials, Athens, GA.

The fundamental principles underlying the application of electricity to tractors and farm equipment are presented. An understanding of the material in the basic manual will enable the service man to understand better the service procedures covered in service manuals on electrical equipment. Topics dealt with are fundamentals of electricity,…

A review of turbine blade tip heat transfer.

PubMed

Bunker, R S

2001-05-01

This paper presents a review of the publicly available knowledge base concerning turbine blade tip heat transfer, from the early fundamental research which laid the foundations of our knowledge, to current experimental and numerical studies utilizing engine-scaled blade cascades and turbine rigs. Focus is placed on high-pressure, high-temperature axial-turbine blade tips, which are prevalent in the majority of today's aircraft engines and power generating turbines. The state of our current understanding of turbine blade tip heat transfer is in the transitional phase between fundamentals supported by engine-based experience, and the ability to a priori correctly predict and efficiently design blade tips for engine service.

How not to criticize the precautionary principle.

PubMed

Hughes, Jonathan

2006-10-01

The precautionary principle has its origins in debates about environmental policy, but is increasingly invoked in bioethical contexts. John Harris and Søren Holm argue that the principle should be rejected as incoherent, irrational, and representing a fundamental threat to scientific advance and technological progress. This article argues that while there are problems with standard formulations of the principle, Harris and Holm's rejection of all its forms is mistaken. In particular, they focus on strong versions of the principle and fail to recognize that weaker forms, which may escape their criticisms, are both possible and advocated in the literature.

Principles of Biomimetic Vascular Network Design Applied to a Tissue-Engineered Liver Scaffold

PubMed Central

Hoganson, David M.; Pryor, Howard I.; Spool, Ira D.; Burns, Owen H.; Gilmore, J. Randall

2010-01-01

Branched vascular networks are a central component of scaffold architecture for solid organ tissue engineering. In this work, seven biomimetic principles were established as the major guiding technical design considerations of a branched vascular network for a tissue-engineered scaffold. These biomimetic design principles were applied to a branched radial architecture to develop a liver-specific vascular network. Iterative design changes and computational fluid dynamic analysis were used to optimize the network before mold manufacturing. The vascular network mold was created using a new mold technique that achieves a 1:1 aspect ratio for all channels. In vitro blood flow testing confirmed the physiologic hemodynamics of the network as predicted by computational fluid dynamic analysis. These results indicate that this biomimetic liver vascular network design will provide a foundation for developing complex vascular networks for solid organ tissue engineering that achieve physiologic blood flow. PMID:20001254

Principles of biomimetic vascular network design applied to a tissue-engineered liver scaffold.

PubMed

Hoganson, David M; Pryor, Howard I; Spool, Ira D; Burns, Owen H; Gilmore, J Randall; Vacanti, Joseph P

2010-05-01

Branched vascular networks are a central component of scaffold architecture for solid organ tissue engineering. In this work, seven biomimetic principles were established as the major guiding technical design considerations of a branched vascular network for a tissue-engineered scaffold. These biomimetic design principles were applied to a branched radial architecture to develop a liver-specific vascular network. Iterative design changes and computational fluid dynamic analysis were used to optimize the network before mold manufacturing. The vascular network mold was created using a new mold technique that achieves a 1:1 aspect ratio for all channels. In vitro blood flow testing confirmed the physiologic hemodynamics of the network as predicted by computational fluid dynamic analysis. These results indicate that this biomimetic liver vascular network design will provide a foundation for developing complex vascular networks for solid organ tissue engineering that achieve physiologic blood flow.

Structuring Light to Manipulate Multipolar Resonances for Metamaterial Applications

NASA Astrophysics Data System (ADS)

Das, Tanya

Multipolar electromagnetic phenomena in sub-wavelength resonators are at the heart of metamaterial science and technology. Typically, researchers engineer multipolar light-matter interactions by modifying the size, shape, and composition of the resonators. Here, we instead engineer multipolar interactions by modifying properties of the incident radiation. In this dissertation, we propose a new framework for determining the scattering response of resonators based on properties of the local excitation field. First, we derive an analytical theory to determine the scattering response of spherical nanoparticles under any type of illumination. Using this theory, we demonstrate the ability to drastically manipulate the scattering properties of a spherical nanoparticle by varying the illumination and demonstrate excitation of a longitudinal quadrupole mode that cannot be accessed with conventional illumination. Next, we investigate the response of dielectric dimer structures illuminated by cylindrical vector beams. Using finite-difference time-domain simulations, we demonstrate significant modification of the scattering spectra of dimer antennas and reveal how the illumination condition gives rise to these spectra through manipulation of electric and magnetic mode hybridization. Finally, we present a simple and efficient numerical simulation based on local field principles for extracting the multipolar response of any resonator under illumination by structured light. This dissertation enhances the understanding of fundamental light-matter interactions in metamaterials and lays the foundation for researchers to identify, quantify, and manipulate multipolar light-matter interactions through optical beam engineering.

Educational ultrasound nondestructive testing laboratory.

PubMed

Genis, Vladimir; Zagorski, Michael

2008-09-01

The ultrasound nondestructive evaluation (NDE) of materials course was developed for applied engineering technology students at Drexel University's Goodwin College of Professional Studies. This three-credit, hands-on laboratory course consists of two parts: the first part with an emphasis on the foundations of NDE, and the second part during which ultrasound NDE techniques are utilized in the evaluation of parts and materials. NDE applications are presented and applied through real-life problems, including calibration and use of the latest ultrasonic testing instrumentation. The students learn engineering and physical principles of measurements of sound velocity in different materials, attenuation coefficients, material thickness, and location and dimensions of discontinuities in various materials, such as holes, cracks, and flaws. The work in the laboratory enhances the fundamentals taught during classroom sessions. This course will ultimately result in improvements in the educational process ["The greater expectations," national panel report, http://www.greaterexpectations.org (last viewed February, 2008); R. M. Felder and R. Brent "The intellectual development of Science and Engineering Students. Part 2: Teaching to promote growth," J. Eng. Educ. 93, 279-291 (2004)] since industry is becoming increasingly reliant on the effective application of NDE technology and the demand on NDE specialists is increasing. NDE curriculum was designed to fulfill levels I and II NDE in theory and training requirements, according to American Society for Nondestructive Testing, OH, Recommended Practice No. SNT-TC-1A (2006).

Light, Imaging, Vision: An interdisciplinary undergraduate course

NASA Astrophysics Data System (ADS)

Nelson, Philip

Students in physical and life science, and in engineering, need to know about the physics and biology of light. In the 21st century, it has become increasingly clear that the quantum nature of light is essential both for the latest imaging modalities and even to advance our knowledge of fundamental processes, such as photosynthesis and human vision. But many optics courses remain rooted in classical physics, with photons as an afterthought. I'll describe a new undergraduate course, for students in several science and engineering majors, that takes students from the rudiments of probability theory to modern methods like fluorescence imaging and Förster resonance energy transfer. After a digression into color vision, students then see how the Feynman principle explains the apparently wavelike phenomena associated to light, including applications like diffraction limit, subdiffraction imaging, total internal reflection and TIRF microscopy. Then we see how scientists documented the single-quantum sensitivity of the eye seven decades earlier than `ought' to have been possible, and finally close with the remarkable signaling cascade that delivers such outstanding performance. A new textbook embodying this course will be published by Princeton University Press in Spring 2017. Partially supported by the United States National Science Foundation under Grant PHY-1601894.

Active Control Of Structure-Borne Noise

NASA Astrophysics Data System (ADS)

Elliott, S. J.

1994-11-01

The successful practical application of active noise control requires an understanding of both its acoustic limitations and the limitations of the electrical control strategy used. This paper is concerned with the active control of sound in enclosures. First, a review is presented of the fundamental physical limitations of using loudspeakers to achieve either global or local control. Both approaches are seen to have a high frequency limit, due to either the acoustic modal overlap, or the spatial correlation function of the pressure field. These physical performance limits could, in principle, be achieved with either a feedback or a feedforward control strategy. These strategies are reviewed and the use of adaptive digital filters is discussed for both approaches. The application of adaptive feedforward control in the control of engine and road noise in cars is described. Finally, an indirect approach to the active control of sound is discussed, in which the vibration is suppressed in the structural paths connecting the source of vibration to the enclosure. Two specific examples of this strategy are described, using an active automotive engine mount and the incorporation of actuators into helicopter struts to control gear-meshing tones. In both cases good passive design can minimize the complexity of the active controller.

Dynamics of Fluids and Transport in Fractured Rock

NASA Astrophysics Data System (ADS)

Faybishenko, Boris; Witherspoon, Paul A.; Gale, John

How to characterize fluid flow, heat, and chemical transport in geologic media remains a central challenge for geo-scientists and engineers worldwide. Investigations of fluid flow and transport within rock relate to such fundamental and applied problems as environmental remediation; nonaqueous phase liquid (NAPL) transport; exploitation of oil, gas, and geothermal resources; disposal of spent nuclear fuel; and geotechnical engineering. It is widely acknowledged that fractures in unsaturated-saturated rock can play a major role in solute transport from the land surface to underlying aquifers. It is also evident that general issues concerning flow and transport predictions in subsurface fractured zones can be resolved in a practical manner by integrating investigations into the physical nature of flow in fractures, developing relevant mathematical models and modeling approaches, and collecting site characterization data. Because of the complexity of flow and transport processes in most fractured rock flow problems, it is not yet possible to develop models directly from first principles. One reason for this is the presence of episodic, preferential water seepage and solute transport, which usually proceed more rapidly than expected from volume-averaged and time-averaged models. However, the physics of these processes is still known.

The re-tooled mind: how culture re-engineers cognition

PubMed Central

2010-01-01

One of the main goals of cognitive science is to discover the underlying principles that characterize human cognition, but this enterprise is complicated by culturally-driven variability. While much fruitful work has focused on how culture influences the contents of cognition, here I argue that culture can in addition exercise a profound effect on the how of cognition—the mechanisms by which cognitive tasks get done. I argue that much of the fundamental processes of daily cognitive activity involve the operation of cognitive tools that are not genetically determined but instead are invented and culturally transmitted. Further, these cognitive inventions become ‘firmware’, consituting a re-engineering of the individual’s cognitive architecture. That is, ontogenetic experience from one’s cultural context serves to re-tool the developing mind into a variety of disparate cognitive phenotypes. Drawing on several mutually isolated literatures, I advance four claims to the effect that cognitive tools (i) are ubitquitous in everyday cognition, (ii) result in reorganization of the neural system, (iii) are founded in embodied representations and (iv) were made possible by the evolution of an unprecedented degree of voluntary control over the body. I conclude by discussing the implications for the agenda of cognitive science. PMID:20068033

Environmental Science. An Experimental Programme for Primary Teachers.

ERIC Educational Resources Information Center

Linke, R. D.

An experimental course covering some of the fundamental principles and terminology associated with environmental science and the application of these principles to various contemporary problems is summarized in this report. The course involved a series of lectures together with a program of specific seminar and discussion topics presented by the…

Institutional Ethics and Values. The Fundamentals. Board Basics.

ERIC Educational Resources Information Center

Corts, Thomas E.

1998-01-01

This booklet offers trustees of institutions of higher education a guide to the ethical principles upon which the institution should base its decisions. An introductory section offers actual examples of unethical decisions by single officials for which the institution was responsible. The following sections each explain a principle and offer…

Epistemic Autonomy: A Criterion for Virtue?

ERIC Educational Resources Information Center

Mudd, Sasha

2013-01-01

Catherine Elgin proposes a novel principle for identifying epistemic virtue. Based loosely on Kant's Categorical Imperative, it identifies autonomy as our fundamental epistemic responsibility, and defines the epistemic virtues as those traits of character needed to exercise epistemic autonomy. I argue that Elgin's principle fails as a…

Seeing the Unseen

ERIC Educational Resources Information Center

Turner, Kenneth; Tevaarwerk, Emma; Unterman, Nathan; Grdinic, Marcel; Campbell, Jason; Chandrasekhar, Venkat; Chang, R. P. H.

2006-01-01

Nanoscience refers to the fundamental study of scientific phenomena, which occur at the nanoscale--nanotechnology to the exploitation of novel properties and functions of materials in the sub-100 nm size range. One of the underlying principles of science is development of models of observed phenomena. In biology, the Hardy-Weinberg principle is a…

Principles of Pesticide Use, Handling, and Application: Instructional Modules for Vocational Agriculture Education. Student Manual.

ERIC Educational Resources Information Center

Ellis Associates, Inc., College Park, MD.

This training package is designed to present the basic principles of pesticide use, handling, and application. Included in this package is information on federal laws and regulations, personal safety, environmental implications, storage and disposal considerations, proper application procedures, and fundamentals of pest management. Successful…

Principles of Pesticide Use, Handling, and Application: Instructional Modules for Vocational Agriculture Education. Teacher Manual.

ERIC Educational Resources Information Center

Ellis Associates, Inc., College Park, MD.

The training package is designed to present the basic principles of pesticide use, handling, and application. Included in this package is information on Federal laws and regulations, personal safety, environmental implications, storage and disposal considerations, proper application procedures, and fundamentals of pest management. Successful…

Basic Comfort Heating Principles.

ERIC Educational Resources Information Center

Dempster, Chalmer T.

The material in this beginning book for vocational students presents fundamental principles needed to understand the heating aspect of the sheet metal trade and supplies practical experience to the student so that he may become familiar with the process of determining heat loss for average structures. Six areas covered are: (1) Background…

Water System Adaptation to Hydrological Changes: Module 10, Basic Principles of Incorporating Adaptation Science into Hydrologic Planning and Design

EPA Science Inventory

This course will introduce students to the fundamental principles of water system adaptation to hydrological changes, with emphasis on data analysis and interpretation, technical planning, and computational modeling. Starting with real-world scenarios and adaptation needs, the co...

Development of Canonical Transformations from Hamilton's Principle.

ERIC Educational Resources Information Center

Quade, C. Richard

1979-01-01

The theory of canonical transformations and its development are discussed with regard to its application to Hutton's principle. Included are the derivation of the equations of motion and a lack of symmetry in the formulaion with respect to Lagrangian and the fundamental commutator relations of quantum mechanics. (Author/SA)

How Do Students in an Innovative Principle-Based Mechanics Course Understand Energy Concepts?

ERIC Educational Resources Information Center

Ding, Lin; Chabay, Ruth; Sherwood, Bruce

2013-01-01

We investigated students' conceptual learning of energy topics in an innovative college-level introductory mechanics course, entitled Matter & Interactions (M&I) Modern Mechanics. This course differs from traditional curricula in that it emphasizes application of a small number of fundamental principles across various scales, involving…

Basic principles of variable speed drives

NASA Technical Reports Server (NTRS)

Loewenthal, S. H.

1973-01-01

An understanding of the principles which govern variable speed drive operation is discussed for successful drive application. The fundamental factors of torque, speed ratio, and power as they relate to drive selection are discussed. The basic types of variable speed drives, their operating characteristics and their applications are also presented.

Providing Experiential Business and Management Training for Biomedical Research Trainees

ERIC Educational Resources Information Center

Petrie, Kimberly A.; Carnahan, Robert H.; Brown, Abigail M.; Gould, Kathleen L.

2017-01-01

Many biomedical PhD trainees lack exposure to business principles, which limits their competitiveness and effectiveness in academic and industry careers. To fill this training gap, we developed Business and Management Principles for Scientists, a semester-long program that combined didactic exposure to business fundamentals with practical…

Designing a 'neotissue' using the principles of biology, chemistry and engineering.

PubMed

Nannaparaju, Madhusudhan; Oragui, Emeka; Khan, Wasim S

2012-01-01

The traditional methods of treating musculoskeletal injuries and disorders are not completely effective and have several limitations. Tissue engineering involves using the principles of biology, chemistry and engineering to design a 'neotissue' that augments a malfunctioning in vivo tissue. The main requirements for functional engineered tissue include reparative cellular components that proliferate on a scaffold grown within a bioreactor that provides specific biochemical and physical signals to regulate cell differentiation and tissue assembly. In this review we provide an overview of the biology of common musculoskeletal tissue and discuss their common pathologies. We also describe the commonly used stem cells, scaffolds and bioreactors and evaluate their role in issue engineering.

Bi-centenary of successes of Fourier theorem: its power and limitations in optical system designs

NASA Astrophysics Data System (ADS)

Roychoudhuri, Chandrasekhar

2007-09-01

We celebrate the two hundred years of successful use of the Fourier theorem in optics. However, there is a great enigma associated with the Fourier transform integral. It is one of the most pervasively productive and useful tool of physics and optics because its foundation is based on the superposition of harmonic functions and yet we have never declared it as a principle of physics for valid reasons. And, yet there are a good number of situations where we pretend it to be equivalent to the superposition principle of physics, creating epistemological problems of enormous magnitude. The purpose of the paper is to elucidate the problems while underscoring the successes and the elegance of the Fourier theorem, which are not explicitly discussed in the literature. We will make our point by taking six major engineering fields of optics and show in each case why it works and under what restricted conditions by bringing in the relevant physics principles. The fields are (i) optical signal processing, (ii) Fourier transform spectrometry, (iii) classical spectrometry of pulsed light, (iv) coherence theory, (v) laser mode locking and (vi) pulse broadening. We underscore that mathematical Fourier frequencies, not being physical frequencies, cannot generate real physical effects on our detectors. Appreciation of this fundamental issue will open up ways to be innovative in many new optical instrument designs. We underscore the importance of always validating our design platforms based on valid physics principles (actual processes undergoing in nature) captured by an appropriate hypothesis based on diverse observations. This paper is a comprehensive view of the power and limitations of Fourier Transform by summarizing a series of SPIE conference papers presented during 2003-2007.

Basic Principles of Marine Diesel Engines, 8-2. Military Curriculum Materials for Vocational and Technical Education.

ERIC Educational Resources Information Center

Ohio State Univ., Columbus. National Center for Research in Vocational Education.

This volume of student materials for a secondary/postsecondary level course in principles of marine diesel engines is one of a number of military-developed curriculum packages selected for adaptation to vocational instruction and curriculum development in a civilian setting. The purpose of the individualized, self-paced course is to acquaint…

Construction Mechanic Part I, 8-5. Military Curriculum Materials for Vocational and Technical Education.

ERIC Educational Resources Information Center

Ohio State Univ., Columbus. National Center for Research in Vocational Education.

This course, adapted from military curriculum materials for use in vocational and technical education, is the first of a two-course series that teaches students to maintain and repair automotive and construction equipment using either gasoline or diesel engines. It covers basic combustion engine principles and electrical system principles as well…

The technology improvement and development of the new design-engineering principles of pilot bore directional drilling

NASA Astrophysics Data System (ADS)

Shadrina, A.; Saruev, L.; Vasenin, S.

2016-09-01

This paper addresses the effectiveness of impact energy use in pilot bore directional drilling at pipe driving. We establish and develop new design-engineering principles for this method. These principles are based on a drill string construction with a new nipple thread connection and a generator construction of strain waves transferred through the drill string. The experiment was conducted on a test bench. Strain measurement is used to estimate compression, tensile, shear and bending stresses in the drill string during the propagation of elastic waves. Finally, the main directions of pilot bore directional drilling improvement during pipe driving are determinated. The new engineering design, as components of the pilot bore directional drilling technology are presented.

Active control of fan noise from a turbofan engine

NASA Technical Reports Server (NTRS)

Thomas, Russell H.; Burdisso, Ricardo A.; Fuller, Christopher R.; O'Brien, Walter F.

1994-01-01

A three-channel active control system is applied to an operational turbofan engine to reduce tonal noise produced by both the fan and the high-pressure compressor. The control approach is the feedforward filtered-x least-mean-square algorithm implemented on a digital signal processing board. Reference transducers mounted on the engine case provide blade passing and harmonics frequency information to the controller. Error information is provided by large area microphones placed in the acoustic far field. To minimize the error signal, the controller actuates loudspeakers mounted on the inlet to produce destructive interference. The sound pressure level of the fundamental tone of the fan was reduced using the three-channel controller by up to 16 dB over a +/- 30-deg angle about the engine axis. A single-channel controller could produce reduction over a +/- 15-deg angle. The experimental results show the control to be robust. Outside of the areas contolled, the levels of the tone actually increased due to the generation of radial modes by the control sources. Simultaneous control of two tones is achieved with parallel controllers. The fundamental and the first harmonic tones of the fan were controlled simultaneously with reductions of 12 and 5 dBA, respectively, measured on the engine axis. Simultaneous control was also demonstrated for the fan fundamental and the high-pressure compressor fundamental tones.

Physical Chemistry of Nanomedicine: Understanding the Complex Behaviors of Nanoparticles in Vivo

NASA Astrophysics Data System (ADS)

Lane, Lucas A.; Qian, Ximei; Smith, Andrew M.; Nie, Shuming

2015-04-01

Nanomedicine is an interdisciplinary field of research at the interface of science, engineering, and medicine, with broad clinical applications ranging from molecular imaging to medical diagnostics, targeted therapy, and image-guided surgery. Despite major advances during the past 20 years, there are still major fundamental and technical barriers that need to be understood and overcome. In particular, the complex behaviors of nanoparticles under physiological conditions are poorly understood, and detailed kinetic and thermodynamic principles are still not available to guide the rational design and development of nanoparticle agents. Here we discuss the interactions of nanoparticles with proteins, cells, tissues, and organs from a quantitative physical chemistry point of view. We also discuss insights and strategies on how to minimize nonspecific protein binding, how to design multistage and activatable nanostructures for improved drug delivery, and how to use the enhanced permeability and retention effect to deliver imaging agents for image-guided cancer surgery.

A variational approach to behavioral and neuroelectrical laws.

PubMed

Noventa, Stefano; Vidotto, Giulio

2012-09-01

Variational methods play a fundamental and unifying role in several fields of physics, chemistry, engineering, economics, and biology, as they allow one to derive the behavior of a system as a consequence of an optimality principle. A possible application of these methods to a model of perception is given by considering a psychophysical law as the solution of an Euler-Lagrange equation. A general class of Lagrangians is identified by requiring the measurability of prothetic continua on interval scales. The associated Hamiltonian (the energy of the process) is tentatively connected with neurophysiological aspects. As an example of the suggested approach a particular choice of the Lagrangian, that is a sufficient condition to obtain classical psychophysical laws, while accounting for psychophysical adaptation and the stationarity of neuronal activity, is used to explore a possible relation between a behavioral law and a neuroelectrical ,response based on the Naka-Rushton model.

Manipulating biological agents and cells in micro-scale volumes for applications in medicine

PubMed Central

Tasoglu, Savas; Gurkan, Umut Atakan; Wang, ShuQi

2013-01-01

Recent technological advances provide new tools to manipulate cells and biological agents in micro/nano-liter volumes. With precise control over small volumes, the cell microenvironment and other biological agents can be bioengineered; interactions between cells and external stimuli can be monitored; and the fundamental mechanisms such as cancer metastasis and stem cell differentiation can be elucidated. Technological advances based on the principles of electrical, magnetic, chemical, optical, acoustic, and mechanical forces lead to novel applications in point-of-care diagnostics, regenerative medicine, in vitro drug testing, cryopreservation, and cell isolation/purification. In this review, we first focus on the underlying mechanisms of emerging examples for cell manipulation in small volumes targeting applications such as tissue engineering. Then, we illustrate how these mechanisms impact the aforementioned biomedical applications, discuss the associated challenges, and provide perspectives for further development. PMID:23575660

Electric-field noise from carbon-adatom diffusion on a Au(110) surface: First-principles calculations and experiments

DOE PAGES

Kim, E.; Safavi-Naini, A.; Hite, D. A.; ...

2017-03-01

The decoherence of trapped-ion quantum bits due to heating of their motional modes is a fundamental science and engineering problem. This heating is attributed to electric-field noise arising from processes on the trap-electrode surfaces. In this work, we address the source of this noise by focusing on the diffusion of carbon-containing adsorbates on the surface of Au(110). We show by detailed scanned probe microscopy and density functional theory how the carbon adatom diffusion on the gold surface changes the energy landscape, and how the adatom dipole moment varies with the diffusive motion. Lastly, a simple model for the diffusion noise,more » which varies quadratically with the variation of the dipole moment, qualitatively reproduces the measured noise spectrum, and the estimate of the noise spectral density is in accord with measured values.« less

Precise Design of Phosphorescent Molecular Butterflies with Tunable Photoinduced Structural Change and Dual Emission.

PubMed

Zhou, Chenkun; Tian, Yu; Yuan, Zhao; Han, Mingu; Wang, Jamie; Zhu, Lei; Tameh, Maliheh Shaban; Huang, Chen; Ma, Biwu

2015-08-10

Photoinduced structural change (PSC) is a fundamental excited-state dynamic process in chemical and biological systems. However, precise control of PSC processes is very challenging, owing to the lack of guidelines for designing excited-state potential energy surfaces (PESs). A series of rationally designed butterfly-like phosphorescent binuclear platinum complexes that undergo controlled PSC by Pt-Pt distance shortening and exhibit tunable dual (greenish-blue and red) emission are herein reported. Based on the Bell-Evans-Polanyi principle, it is demonstrated how the energy barrier of the PSC, which can be described as a chemical-reaction-like process between the two energy minima on the first triplet excited-state PES, can be controlled by synthetic means. These results reveal a simple method to engineer the dual emission of molecular systems by manipulating PES to control PSC. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

IgGs are made for walking on bacterial and viral surfaces

NASA Astrophysics Data System (ADS)

Preiner, Johannes; Kodera, Noriyuki; Tang, Jilin; Ebner, Andreas; Brameshuber, Mario; Blaas, Dieter; Gelbmann, Nicola; Gruber, Hermann J.; Ando, Toshio; Hinterdorfer, Peter

2014-07-01

Binding of antibodies to their cognate antigens is fundamental for adaptive immunity. Molecular engineering of antibodies for therapeutic and diagnostic purposes emerges to be one of the major technologies in combating many human diseases. Despite its importance, a detailed description of the nanomechanical process of antibody-antigen binding and dissociation on the molecular level is lacking. Here we utilize high-speed atomic force microscopy to examine the dynamics of antibody recognition and uncover a principle; antibodies do not remain stationary on surfaces of regularly spaced epitopes; they rather exhibit ‘bipedal’ stochastic walking. As monovalent Fab fragments do not move, steric strain is identified as the origin of short-lived bivalent binding. Walking antibodies gather in transient clusters that might serve as docking sites for the complement system and/or phagocytes. Our findings could inspire the rational design of antibodies and multivalent receptors to exploit/inhibit steric strain-induced dynamic effects.

X-ray phase-contrast imaging

NASA Astrophysics Data System (ADS)

Endrizzi, Marco

2018-01-01

X-ray imaging is a standard tool for the non-destructive inspection of the internal structure of samples. It finds application in a vast diversity of fields: medicine, biology, many engineering disciplines, palaeontology and earth sciences are just few examples. The fundamental principle underpinning the image formation have remained the same for over a century: the X-rays traversing the sample are subjected to different amount of absorption in different parts of the sample. By means of phase-sensitive techniques it is possible to generate contrast also in relation to the phase shifts imparted by the sample and to extend the capabilities of X-ray imaging to those details that lack enough absorption contrast to be visualised in conventional radiography. A general overview of X-ray phase contrast imaging techniques is presented in this review, along with more recent advances in this fast evolving field and some examples of applications.

Identification of novel direct protein-protein interactions by irradiating living cells with femtosecond UV laser pulses.

PubMed

Itri, Francesco; Monti, Daria Maria; Chino, Marco; Vinciguerra, Roberto; Altucci, Carlo; Lombardi, Angela; Piccoli, Renata; Birolo, Leila; Arciello, Angela

2017-10-07

The identification of protein-protein interaction networks in living cells is becoming increasingly fundamental to elucidate main biological processes and to understand disease molecular bases on a system-wide level. We recently described a method (LUCK, Laser UV Cross-linKing) to cross-link interacting protein surfaces in living cells by UV laser irradiation. By using this innovative methodology, that does not require any protein modification or cell engineering, here we demonstrate that, upon UV laser irradiation of HeLa cells, a direct interaction between GAPDH and alpha-enolase was "frozen" by a cross-linking event. We validated the occurrence of this direct interaction by co-immunoprecipitation and Immuno-FRET analyses. This represents a proof of principle of the LUCK capability to reveal direct protein interactions in their physiological environment. Copyright © 2017 Elsevier Inc. All rights reserved.

Design of virus-based nanomaterials for medicine, biotechnology, and energy.

PubMed

Wen, Amy M; Steinmetz, Nicole F

2016-07-25

This review provides an overview of recent developments in "chemical virology." Viruses, as materials, provide unique nanoscale scaffolds that have relevance in chemical biology and nanotechnology, with diverse areas of applications. Some fundamental advantages of viruses, compared to synthetically programmed materials, include the highly precise spatial arrangement of their subunits into a diverse array of shapes and sizes and many available avenues for easy and reproducible modification. Here, we will first survey the broad distribution of viruses and various methods for producing virus-based nanoparticles, as well as engineering principles used to impart new functionalities. We will then examine the broad range of applications and implications of virus-based materials, focusing on the medical, biotechnology, and energy sectors. We anticipate that this field will continue to evolve and grow, with exciting new possibilities stemming from advancements in the rational design of virus-based nanomaterials.

Quantum chaos and breaking of all anti-unitary symmetries in Rydberg excitons.

PubMed

Aßmann, Marc; Thewes, Johannes; Fröhlich, Dietmar; Bayer, Manfred

2016-07-01

Symmetries are the underlying principles of fundamental interactions in nature. Chaos in a quantum system may emerge from breaking these symmetries. Compared to vacuum, crystals are attractive for studying quantum chaos, as they not only break spatial isotropy, but also lead to novel quasiparticles with modified interactions. Here we study yellow Rydberg excitons in cuprous oxide which couple strongly to the vacuum light field and interact significantly with crystal phonons, leading to inversion symmetry breaking. In a magnetic field, time-reversal symmetry is also broken and the exciton states show a complex splitting pattern, resulting in quadratic level repulsion for small splittings. In contrast to atomic chaotic systems in a magnetic field, which show only a linear level repulsion, this is a signature of a system where all anti-unitary symmetries are broken simultaneously. This behaviour can otherwise be found only for the electro-weak interaction or engineered billiards.

A General Approach for Fluid Patterning and Application in Fabricating Microdevices.

PubMed

Huang, Zhandong; Yang, Qiang; Su, Meng; Li, Zheng; Hu, Xiaotian; Li, Yifan; Pan, Qi; Ren, Wanjie; Li, Fengyu; Song, Yanlin

2018-06-19

Engineering the fluid interface such as the gas-liquid interface is of great significance for solvent processing applications including functional material assembly, inkjet printing, and high-performance device fabrication. However, precisely controlling the fluid interface remains a great challenge owing to its flexibility and fluidity. Here, a general method to manipulate the fluid interface for fluid patterning using micropillars in the microchannel is reported. The principle of fluid patterning for immiscible fluid pairs including air, water, and oils is proposed. This understanding enables the preparation of programmable multiphase fluid patterns and assembly of multilayer functional materials to fabricate micro-optoelectronic devices. This general strategy of fluid patterning provides a promising platform to study the fundamental processes occurring on the fluid interface, and benefits applications in many subjects, such as microfluidics, microbiology, chemical analysis and detection, material synthesis and assembly, device fabrication, etc. © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Electric-field noise from carbon-adatom diffusion on a Au(110) surface: First-principles calculations and experiments

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kim, E.; Safavi-Naini, A.; Hite, D. A.

The decoherence of trapped-ion quantum bits due to heating of their motional modes is a fundamental science and engineering problem. This heating is attributed to electric-field noise arising from processes on the trap-electrode surfaces. In this work, we address the source of this noise by focusing on the diffusion of carbon-containing adsorbates on the surface of Au(110). We show by detailed scanned probe microscopy and density functional theory how the carbon adatom diffusion on the gold surface changes the energy landscape, and how the adatom dipole moment varies with the diffusive motion. Lastly, a simple model for the diffusion noise,more » which varies quadratically with the variation of the dipole moment, qualitatively reproduces the measured noise spectrum, and the estimate of the noise spectral density is in accord with measured values.« less

Interface engineering of quantum Hall effects in digital transition metal oxide heterostructures.

PubMed

Xiao, Di; Zhu, Wenguang; Ran, Ying; Nagaosa, Naoto; Okamoto, Satoshi

2011-12-20

Topological insulators are characterized by a non-trivial band topology driven by the spin-orbit coupling. To fully explore the fundamental science and application of topological insulators, material realization is indispensable. Here we predict, based on tight-binding modelling and first-principles calculations, that bilayers of perovskite-type transition-metal oxides grown along the [111] crystallographic axis are potential candidates for two-dimensional topological insulators. The topological band structure of these materials can be fine-tuned by changing dopant ions, substrates and external gate voltages. We predict that LaAuO(3) bilayers have a topologically non-trivial energy gap of about 0.15 eV, which is sufficiently large to realize the quantum spin Hall effect at room temperature. Intriguing phenomena, such as fractional quantum Hall effect, associated with the nearly flat topologically non-trivial bands found in e(g) systems are also discussed.

Distribution and dynamics of electron transport complexes in cyanobacterial thylakoid membranes☆

PubMed Central

Liu, Lu-Ning

2016-01-01

The cyanobacterial thylakoid membrane represents a system that can carry out both oxygenic photosynthesis and respiration simultaneously. The organization, interactions and mobility of components of these two electron transport pathways are indispensable to the biosynthesis of thylakoid membrane modules and the optimization of bioenergetic electron flow in response to environmental changes. These are of fundamental importance to the metabolic robustness and plasticity of cyanobacteria. This review summarizes our current knowledge about the distribution and dynamics of electron transport components in cyanobacterial thylakoid membranes. Global understanding of the principles that govern the dynamic regulation of electron transport pathways in nature will provide a framework for the design and synthetic engineering of new bioenergetic machinery to improve photosynthesis and biofuel production. This article is part of a Special Issue entitled: Organization and dynamics of bioenergetic systems in bacteria, edited by Conrad Mullineaux. PMID:26619924

Rheological Principles for Food Analysis

NASA Astrophysics Data System (ADS)

Daubert, Christopher R.; Foegeding, E. Allen

Food scientists are routinely confronted with the need to measure physical properties related to sensory texture and processing needs. These properties are determined by rheological methods, where rheology is a science devoted to the deformation and flow of all materials. Rheological properties should be considered a subset of the textural properties of foods, because the sensory detection of texture encompasses factors beyond rheological properties. Specifically, rheological methods accurately measure "force," "deformation," and "flow," and food scientists and engineers must determine how best to apply this information. For example, the flow of salad dressing from a bottle, the snapping of a candy bar, or the pumping of cream through a homogenizer are each related to the rheological properties of these materials. In this chapter, we describe fundamental concepts pertinent to the understanding of the subject and discuss typical examples of rheological tests for common foods. A glossary is included as Sect. 30.6 to clarify and summarize rheological definitions throughout the chapter.

Distribution and dynamics of electron transport complexes in cyanobacterial thylakoid membranes.

PubMed

Liu, Lu-Ning

2016-03-01

The cyanobacterial thylakoid membrane represents a system that can carry out both oxygenic photosynthesis and respiration simultaneously. The organization, interactions and mobility of components of these two electron transport pathways are indispensable to the biosynthesis of thylakoid membrane modules and the optimization of bioenergetic electron flow in response to environmental changes. These are of fundamental importance to the metabolic robustness and plasticity of cyanobacteria. This review summarizes our current knowledge about the distribution and dynamics of electron transport components in cyanobacterial thylakoid membranes. Global understanding of the principles that govern the dynamic regulation of electron transport pathways in nature will provide a framework for the design and synthetic engineering of new bioenergetic machinery to improve photosynthesis and biofuel production. This article is part of a Special Issue entitled: Organization and dynamics of bioenergetic systems in bacteria, edited by Conrad Mullineaux. Copyright © 2015 The Author. Published by Elsevier B.V. All rights reserved.

Trapped-Ion Quantum Logic with Global Radiation Fields.

PubMed

Weidt, S; Randall, J; Webster, S C; Lake, K; Webb, A E; Cohen, I; Navickas, T; Lekitsch, B; Retzker, A; Hensinger, W K

2016-11-25

Trapped ions are a promising tool for building a large-scale quantum computer. However, the number of required radiation fields for the realization of quantum gates in any proposed ion-based architecture scales with the number of ions within the quantum computer, posing a major obstacle when imagining a device with millions of ions. Here, we present a fundamentally different approach for trapped-ion quantum computing where this detrimental scaling vanishes. The method is based on individually controlled voltages applied to each logic gate location to facilitate the actual gate operation analogous to a traditional transistor architecture within a classical computer processor. To demonstrate the key principle of this approach we implement a versatile quantum gate method based on long-wavelength radiation and use this method to generate a maximally entangled state of two quantum engineered clock qubits with fidelity 0.985(12). This quantum gate also constitutes a simple-to-implement tool for quantum metrology, sensing, and simulation.

Education Program for Ph.D. Course to Cultivate Literacy and Competency

NASA Astrophysics Data System (ADS)

Yokono, Yasuyuki; Mitsuishi, Mamoru

The program aims to cultivate internationally competitive young researchers equipped with Fundamental attainment (mathematics, physics, chemistry and biology, and fundamental social sciences) , Specialized knowledge (mechanical dynamics, mechanics of materials, hydrodynamics, thermodynamics, design engineering, manufacturing engineering and material engineering, and bird‧s-eye view knowledge on technology, society and the environment) , Literacy (Language, information literacy, technological literacy and knowledge of the law) and Competency (Creativity, problem identification and solution, planning and execution, self-management, teamwork, leadership, sense of responsibility and sense of duty) to become future leaders in industry and academia.

Fundamental principles of data assimilation underlying the Verdandi library: applications to biophysical model personalization within euHeart.

PubMed

Chapelle, D; Fragu, M; Mallet, V; Moireau, P

2013-11-01

We present the fundamental principles of data assimilation underlying the Verdandi library, and how they are articulated with the modular architecture of the library. This translates--in particular--into the definition of standardized interfaces through which the data assimilation library interoperates with the model simulation software and the so-called observation manager. We also survey various examples of data assimilation applied to the personalization of biophysical models, in particular, for cardiac modeling applications within the euHeart European project. This illustrates the power of data assimilation concepts in such novel applications, with tremendous potential in clinical diagnosis assistance.

A defense of fundamental principles and human rights: a reply to Robert Baker.

PubMed

Macklin, Ruth

1998-12-01

This article seeks to rebut Robert Baker's contention that attempts to ground international bioethics in fundamental principles cannot withstand the challenges posed by multiculturalism and postmodernism. First, several corrections are provided of Baker's account of the conclusions reached by the Advisory Committee on Human Radiation Experiments. Second, a rebuttal is offered to Baker's claim that an unbridgeable moral gap exists between Western individualism and non-Western communalism. In conclusion, this article argues that Baker's "nonnegotiable primary goods" cannot do the work of "classical human rights" and that the latter framework is preferable from both a practical and a theoretical standpoint.

Human Systems Integration Competency Development for Navy Systems Commands

DTIC Science & Technology

2012-09-01

cognizance of Applied Engineering /Psychology relative to knowledge engineering, training, teamwork, user interface design and decision sciences. KSA...cognizance of Applied Engineering /Psychology relative to knowledge engineering, training, teamwork, user interface design and decision sciences...requirements (as required). Fundamental cognizance of Applied Engineering / Psychology relative to knowledge engineering, training, team work, user

Fundamental principles in periodontal plastic surgery and mucosal augmentation--a narrative review.

PubMed

Burkhardt, Rino; Lang, Niklaus P

2014-04-01

To provide a narrative review of the current literature elaborating on fundamental principles of periodontal plastic surgical procedures. Based on a presumptive outline of the narrative review, MESH terms have been used to search the relevant literature electronically in the PubMed and Cochrane Collaboration databases. If possible, systematic reviews were included. The review is divided into three phases associated with periodontal plastic surgery: a) pre-operative phase, b) surgical procedures and c) post-surgical care. The surgical procedures were discussed in the light of a) flap design and preparation, b) flap mobilization and c) flap adaptation and stabilization. Pre-operative paradigms include the optimal plaque control and smoking counselling. Fundamental principles in surgical procedures address basic knowledge in anatomy and vascularity, leading to novel appropriate flap designs with papilla preservation. Flap mobilization based on releasing incisions can be performed up to 5 mm. Flap adaptation and stabilization depend on appropriate wound bed characteristics, undisturbed blood clot formation, revascularization and wound stability through adequate suturing. Delicate tissue handling and tension free wound closure represent prerequisites for optimal healing outcomes. © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Evolutionary engineering for industrial microbiology.

PubMed

Vanee, Niti; Fisher, Adam B; Fong, Stephen S

2012-01-01

Superficially, evolutionary engineering is a paradoxical field that balances competing interests. In natural settings, evolution iteratively selects and enriches subpopulations that are best adapted to a particular ecological niche using random processes such as genetic mutation. In engineering desired approaches utilize rational prospective design to address targeted problems. When considering details of evolutionary and engineering processes, more commonality can be found. Engineering relies on detailed knowledge of the problem parameters and design properties in order to predict design outcomes that would be an optimized solution. When detailed knowledge of a system is lacking, engineers often employ algorithmic search strategies to identify empirical solutions. Evolution epitomizes this iterative optimization by continuously diversifying design options from a parental design, and then selecting the progeny designs that represent satisfactory solutions. In this chapter, the technique of applying the natural principles of evolution to engineer microbes for industrial applications is discussed to highlight the challenges and principles of evolutionary engineering.

Why firewalls need not exist

DOE PAGES

Nomura, Yasunori; Salzetta, Nico

2016-08-04

The firewall paradox for black holes is often viewed as indicating a conflict between unitarity and the equivalence principle. We elucidate how the paradox manifests as a limitation of semiclassical theory, rather than presents a conflict between fundamental principles. Two principal features of the fundamental and semiclassical theories address two versions of the paradox: the entanglement and typicality arguments. First, the physical Hilbert space describing excitations on a fixed black hole background in the semiclassical theory is exponentially smaller than the number of physical states in the fundamental theory of quantum gravity. Second, in addition to the Hilbert space formore » physical excitations, the semiclassical theory possesses an unphysically large Fock space built by creation and annihilation operators on the fixed black hole background. Understanding these features not only eliminates the necessity of firewalls but also leads to a new picture of Hawking emission contrasting pair creation at the horizon.« less

Human/Computer Transaction Tasks: An Annotated Bibliography.

DTIC Science & Technology

1982-05-01

Operations (Manpower, Personnel, and Training, OP-01). The subproject was directed toward resolving fundamental human engineering design issues in...1978 and results were used at the Navy Personnel Research and Development Center in research to resolve fundamental human engineering design issues for...Dialogue Monitor and analysis of Sthe data obtained are briefly discussed. Alden, D. G., Daniels, P. 3., and Kanarick, A. F. Keyboard design and

Suggested criteria for evaluating systems engineering methodologies

NASA Technical Reports Server (NTRS)

Gates, Audrey; Paul, Arthur S.; Gill, Tepper L.

1989-01-01

Systems engineering is the application of mathematical and scientific principles to practical ends in the life-cycle of a system. A methodology for systems engineering is a carefully developed, relatively complex procedure or process for applying these mathematical and scientific principles. There are many systems engineering methodologies (or possibly many versions of a few methodologies) currently in use in government and industry. These methodologies are usually designed to meet the needs of a particular organization. It has been observed, however, that many technical and non-technical problems arise when inadequate systems engineering methodologies are applied by organizations to their systems development projects. Various criteria for evaluating systems engineering methodologies are discussed. Such criteria are developed to assist methodology-users in identifying and selecting methodologies that best fit the needs of the organization.

Autonomous intelligent cars: proof that the EPSRC Principles are future-proof

NASA Astrophysics Data System (ADS)

de Cock Buning, Madeleine; de Bruin, Roeland

2017-07-01

Principle 2 of the EPSRC's principles of robotics (AISB workshop on Principles of Robotics, 2016) proves to be future proof when applied to the current state of the art of law and technology surrounding autonomous intelligent cars (AICs). Humans, not AICS, are responsible agents. AICs should be designed; operated as far as is practicable to comply with existing laws and fundamental rights and freedoms, including privacy by design. It will show that some legal questions arising from autonomous intelligent driving technology can be answered by the technology itself.

Safe use of cellular telephones in hospitals: fundamental principles and case studies.

PubMed

Cohen, Ted; Ellis, Willard S; Morrissey, Joseph J; Bakuzonis, Craig; David, Yadin; Paperman, W David

2005-01-01

Many industries and individuals have embraced cellular telephones. They provide mobile, synchronous communication, which could hypothetically increase the efficiency and safety of inpatient healthcare. However, reports of early analog cellular telephones interfering with critical life-support machines had led many hospitals to strictly prohibit cellular telephones. A literature search revealed that individual hospitals now are allowing cellular telephone use with various policies to prevent electromagnetic interference with medical devices. The fundamental principles underlying electromagnetic interference are immunity, frequency, modulation technology, distance, and power Electromagnetic interference risk mitigation methods based on these principles have been successfully implemented. In one case study, a minimum distance between cellular telephones and medical devices is maintained, with restrictions in critical areas. In another case study, cellular telephone coverage is augmented to automatically control the power of the cellular telephone. While no uniform safety standard yet exists, cellular telephones can be safely used in hospitals when their use is managed carefully.

Detection principles of biological and chemical FET sensors.

PubMed

Kaisti, Matti

2017-12-15

The seminal importance of detecting ions and molecules for point-of-care tests has driven the search for more sensitive, specific, and robust sensors. Electronic detection holds promise for future miniaturized in-situ applications and can be integrated into existing electronic manufacturing processes and technology. The resulting small devices will be inherently well suited for multiplexed and parallel detection. In this review, different field-effect transistor (FET) structures and detection principles are discussed, including label-free and indirect detection mechanisms. The fundamental detection principle governing every potentiometric sensor is introduced, and different state-of-the-art FET sensor structures are reviewed. This is followed by an analysis of electrolyte interfaces and their influence on sensor operation. Finally, the fundamentals of different detection mechanisms are reviewed and some detection schemes are discussed. In the conclusion, current commercial efforts are briefly considered. Copyright © 2017 The Authors. Published by Elsevier B.V. All rights reserved.

Diesel Technology: Engines. [Teacher and Student Editions.

ERIC Educational Resources Information Center

Barbieri, Dave; Miller, Roger; Kellum, Mary

Competency-based teacher and student materials on diesel engines are provided for a diesel technology curriculum. Seventeen units of instruction cover the following topics: introduction to engine principles and procedures; engine systems and components; fuel systems; engine diagnosis and maintenance. The materials are based on the…

A Content-Driven Approach to Visual Literacy: Gestalt Rediscovered.

ERIC Educational Resources Information Center

Schamber, Linda

The goal of an introductory graphics course is fundamental visual literacy, which includes learning to appreciate the power of visuals in communication and to express ideas visually. Traditional principles of design--the focus of the course--are based on more fundamental gestalt theory, which relates to human pattern-seeking behavior, particularly…

On-Line Syntax: Thoughts on the Temporality of Spoken Language

ERIC Educational Resources Information Center

Auer, Peter

2009-01-01

One fundamental difference between spoken and written language has to do with the "linearity" of speaking in time, in that the temporal structure of speaking is inherently the outcome of an interactive process between speaker and listener. But despite the status of "linearity" as one of Saussure's fundamental principles, in practice little more…

Religious Fundamentalism among Young Muslims in Egypt and Saudi Arabia

ERIC Educational Resources Information Center

Moaddel, Mansoor; Karabenick, Stuart A.

2008-01-01

Religious fundamentalism is conceived as a distinctive set of beliefs and attitudes toward one's religion, including obedience to religious norms, belief in the universality and immutability of its principles, the validity of its claims, and its indispensability for human happiness. Surveys of Egyptian and Saudi youth, ages 18-25, reveal that…

Introduction to the Control of Electric Motors.

ERIC Educational Resources Information Center

Spencer, Frederick

The fundamentals of electric circuits and electric machines are presented in the text, with an emphasis on the practical operation rather than on mathematical analyses of theories involved. The material contained in the text includes the fundamentals of both D.C. and A.C. circuits together with the principles of magnetism and electro-magnetic…

Landslides! Engaging students in natural hazards and STEM principles through the exploration of landslide analog models

NASA Astrophysics Data System (ADS)

Gochis, E. E.; Lechner, H. N.; Brill, K. A.; Lerner, G.; Ramos, E.

2014-12-01

Graduate students at Michigan Technological University developed the "Landslides!" activity to engage middle & high school students participating in summer engineering programs in a hands-on exploration of geologic engineering and STEM (Science, Technology, Engineering and Math) principles. The inquiry-based lesson plan is aligned to Next Generation Science Standards and is appropriate for 6th-12th grade classrooms. During the activity students focus on the factors contributing to landslide development and engineering practices used to mitigate hazards of slope stability hazards. Students begin by comparing different soil types and by developing predictions of how sediment type may contribute to differences in slope stability. Working in groups, students then build tabletop hill-slope models from the various materials in order to engage in evidence-based reasoning and test their predictions by adding groundwater until each group's modeled slope fails. Lastly students elaborate on their understanding of landslides by designing 'engineering solutions' to mitigate the hazards observed in each model. Post-evaluations from students demonstrate that they enjoyed the hands-on nature of the activity and the application of engineering principles to mitigate a modeled natural hazard.

Elementary Education Program for Engineering by Dual System of Workshop and Teaching Program with Practical Subject

NASA Astrophysics Data System (ADS)

Hara, Toshitsugu

Elementary education program for engineering by the dual system combined with workshop program and teaching program with practical subject was discussed. The dual system which consists of several workshop programs and fundamental subjects (such as mathematics, English and physics) with practical material has been performed for the freshmen. The elementary workshop program (primary course) has four workshops and the related lectures. Fundamental subjects are taught with the practical or engineering texts. English subjects are taught by specified teachers who have ever worked in engineering field with English. The dual system was supported by such systems as the center for success initiative and the English education center.

Principles of Guided Missiles and Nuclear Weapons.

ERIC Educational Resources Information Center

Naval Personnel Program Support Activity, Washington, DC.

Fundamentals of missile and nuclear weapons systems are presented in this book which is primarily prepared as the second text of a three-volume series for students of the Navy Reserve Officers' Training Corps and the Officer Candidate School. Following an introduction to guided missiles and nuclear physics, basic principles and theories are…

Applying Universal Design for Learning in Online Courses: Pedagogical and Practical Considerations

ERIC Educational Resources Information Center

Dell, Cindy Ann; Dell, Thomas F.; Blackwell, Terry L.

2015-01-01

Inclusion of the universal design for learning (UDL) model as a guiding set of principles for online curriculum development in higher education is discussed. Fundamentally, UDL provides the student with multiple means of accessing the course based on three overarching principles: presentation; action and expression; and engagement and interaction.…

Devising Principles of Design for Numeracy Tasks

ERIC Educational Resources Information Center

Geiger, Vince; Forgasz, Helen; Goos, Merrilyn; Bennison, Anne

2014-01-01

Numeracy is a fundamental component of the Australian National Curriculum as a General Capability identified in each F-10 subject. In this paper, we consider the principles of design necessary for the development of numeracy tasks specific to subjects other than mathematics--in this case, the subject of English. We explore the nature of potential…

Invisible Ink Revealed: Concept, Context, and Chemical Principles of "Cold War" Writing

ERIC Educational Resources Information Center

Macrakis, Kristie; Bell, Elizabeth K.; Perry, Dale L.; Sweeder, Ryan D.

2012-01-01

By modifying secret writing formulas uncovered from the archives of the East German Ministry of State Security (MfS or Stasi), a novel general chemistry secret writing laboratory was developed. The laboratory combines science and history that highlights several fundamental chemical principles related to the writing. These include catalysis, redox…

A century of genetics

Treesearch

Daniel J. Fairbanks

2001-01-01

In 1866, Gregor Mendel published his experiments on heredity in the garden pea (Pisum sativum). The fundamental principles of inheritance derived from his work apply to nearly all eukaryotic species and are now known as Mendelian principles. Since 1900, Mendel has been recognized as the founder of genetics. In 1900, three botanists, Carl Correns, Hugo De Vries, and...

The Didactic Principles and Their Applications in the Didactic Activity

ERIC Educational Resources Information Center

Marius-Costel, Esi

2010-01-01

The evaluation and reevaluation of the fundamental didactic principles suppose the acceptance at the level of an instructive-educative activity of a new educational paradigm. Thus, its understanding implies an assumption at a conceptual-theoretical level of some approaches where the didactic aspects find their usefulness by relating to value…

From Barrier Free to Safe Environments: The New Zealand Experience. Monograph #44.

ERIC Educational Resources Information Center

Wrightson, William; Pope, Campbell

Intrinsically safe design is presented as a logical extension of the principles of barrier free design, and as a higher level design strategy for effecting widespread implementation of the basic accessibility requirements for people with disabilities. Two fundamental planning procedures are proposed: including principles of safe and accessible…

Compression as a Universal Principle of Animal Behavior

ERIC Educational Resources Information Center

Ferrer-i-Cancho, Ramon; Hernández-Fernández, Antoni; Lusseau, David; Agoramoorthy, Govindasamy; Hsu, Minna J.; Semple, Stuart

2013-01-01

A key aim in biology and psychology is to identify fundamental principles underpinning the behavior of animals, including humans. Analyses of human language and the behavior of a range of non-human animal species have provided evidence for a common pattern underlying diverse behavioral phenomena: Words follow Zipf's law of brevity (the…

Translational Behavior Analysis: From Laboratory Science in Stimulus Control to Intervention with Persons with Neurodevelopmental Disabilities

ERIC Educational Resources Information Center

McIlvane, William J.

2009-01-01

Throughout its history, laboratory research in the experimental analysis of behavior has been successful in elucidating and clarifying basic learning principles and processes in both humans and nonhumans. In parallel, applied behavior analysis has shown how fundamental behavior-analytic principles and procedures can be employed to promote…

Limits of transparency of transparent conducting oxides

NASA Astrophysics Data System (ADS)

Peelaers, Hartwin

A fundamental understanding of the factors that limit transparency in transparent conducting oxides (TCOs) is essential for further progress in materials and applications. These materials have a sufficiently large band gap, so that direct optical transitions do not lead to absorption of light within the visible spectrum. Since the presence of free carriers is essential for conductivity and thus for device applications, this introduces the possibility of additional absorption processes. In particular, indirect processes are possible, and these will constitute a fundamental limit of the material. The Drude theory is widely used to describe free-carrier absorption, but it is phenomenological in nature and tends to work poorly at shorter wavelengths, where band-structure effects are important. We will present calculations of phonon- and defect-assisted free-carrier absorption in a TCO completely from first principles. We will focus in detail on SnO2, but the methodology is general and we will also compare the results obtained for other TCO materials such as In2O3. These calculations provide not just quantitative results but also deeper insights in the mechanisms that govern absorption processes, which is essential for engineering improved materials to be used in more efficient devices. This work was performed in collaboration with E. Kioupakis and C.G. Van de Walle and was supported by ARO and NSF.

Fundamental and progress of Bi2Te3-based thermoelectric materials

NASA Astrophysics Data System (ADS)

Hong, Min; Chen, Zhi-Gang; Zou, Jin

2018-04-01

Thermoelectric materials, enabling the directing conversion between heat and electricity, are one of the promising candidates for overcoming environmental pollution and the upcoming energy shortage caused by the over-consumption of fossil fuels. Bi2Te3-based alloys are the classical thermoelectric materials working near room temperature. Due to the intensive theoretical investigations and experimental demonstrations, significant progress has been achieved to enhance the thermoelectric performance of Bi2Te3-based thermoelectric materials. In this review, we first explored the fundamentals of thermoelectric effect and derived the equations for thermoelectric properties. On this basis, we studied the effect of material parameters on thermoelectric properties. Then, we analyzed the features of Bi2Te3-based thermoelectric materials, including the lattice defects, anisotropic behavior and the strong bipolar conduction at relatively high temperature. Then we accordingly summarized the strategies for enhancing the thermoelectric performance, including point defect engineering, texture alignment, and band gap enlargement. Moreover, we highlighted the progress in decreasing thermal conductivity using nanostructures fabricated by solution grown method, ball milling, and melt spinning. Lastly, we employed modeling analysis to uncover the principles of anisotropy behavior and the achieved enhancement in Bi2Te3, which will enlighten the enhancement of thermoelectric performance in broader materials.

National health policy: a draft prepared by the Indian Medical Association.

PubMed

1979-03-16

The draft of the Indian national health policy deals with health as a fundamental right, the expenses of health, health as an integral part of national development, the health movement, the role of indigenous systems, priority in health care, and the infrastructure of health care delivery. The principles outlined in the policy focus on improvement of living conditions, health education and the health movement, preventive and promotive health, coverage of the felt needs of the people, primary health care, continuing medical education, pharmaceuticals, medical education curriculum, biomedical engineering, legislation, coordination, health insurance, and nationalization. In order for this policy to be implemented, proper strategy and planning needs to be carried out after identifying short-term and long-tern goals. The short-term goals include the following: declaration by the government that enjoyment of health is a fundamental right; 2) eradication/control of communicable diseases; 3) provision of adequate nutrition and rational health care in the rural areas and urban slums; 4) organization of a health movement and health education of the people and spread the message of health and family welfare; and 5) identification of the different areas of indigenous system of medicine to initiate scientific scrutiny of these areas for incorporation in the modern scientific system.

Multidisciplinary Russian biomedical research in space

NASA Astrophysics Data System (ADS)

Orlov, O. I.; Sychev, V. N.; Samarin, G. I.; Ilyin, E. A.; Belakovskiy, M. S.; Kussmaul, A. R.

2014-08-01

Research activities on a comprehensive multidisciplinary program are vital for enhancement of the system of crew's medical care, environmental health and hygiene in space missions. The primary goal of the program must be identification of patterns, intensity and dynamics of structural and functional shifts in organism induced by an aggregate of spaceflight factors including microgravity, isolation, artificial environment, space radiation, etc. Also, the program must pursue differential assessment of emerging deviations from the standpoint of adequacy to the spaceflight conditions and prospects of returning to Earth and guide the development of principles, methods and techniques necessary to maintain health and working capacity of humans during short- and long-duration missions and on return to Earth. Over 50 years, since 1963, the IBMP researchers apply systemic and innovational approaches to fundamental and exploratory studies in the fields of medical sciences, radiation biology, engineering science, biotechnology, etc. with participation of various biological specimens and human volunteers. Investigations aboard manned spacecrafts and biological satellites as well as in ground-based laboratories further enhancement of the medical care system for crews on orbital and remote space missions; they give insight into the fundamental problems of gravitational physiology and biology, psychophysiology, radiation biology, and contribute thereby to the development of knowledge, methods and technologies, as well as medical and scientific equipment.

Principles for integrating reactive species into in vivo biological processes: Examples from exercise physiology.

PubMed

Margaritelis, Nikos V; Cobley, James N; Paschalis, Vassilis; Veskoukis, Aristidis S; Theodorou, Anastasios A; Kyparos, Antonios; Nikolaidis, Michalis G

2016-04-01

The equivocal role of reactive species and redox signaling in exercise responses and adaptations is an example clearly showing the inadequacy of current redox biology research to shed light on fundamental biological processes in vivo. Part of the answer probably relies on the extreme complexity of the in vivo redox biology and the limitations of the currently applied methodological and experimental tools. We propose six fundamental principles that should be considered in future studies to mechanistically link reactive species production to exercise responses or adaptations: 1) identify and quantify the reactive species, 2) determine the potential signaling properties of the reactive species, 3) detect the sources of reactive species, 4) locate the domain modified and verify the (ir)reversibility of post-translational modifications, 5) establish causality between redox and physiological measurements, 6) use selective and targeted antioxidants. Fulfilling these principles requires an idealized human experimental setting, which is certainly a utopia. Thus, researchers should choose to satisfy those principles, which, based on scientific evidence, are most critical for their specific research question. Copyright © 2015 Elsevier Inc. All rights reserved.

Standardized Curriculum for Diesel Engine Mechanics.

ERIC Educational Resources Information Center

Mississippi State Dept. of Education, Jackson. Office of Vocational, Technical and Adult Education.

Standardized curricula are provided for two courses for the secondary vocational education program in Mississippi: diesel engine mechanics I and II. The eight units in diesel engine mechanics I are as follows: orientation; shop safety; basic shop tools; fasteners; measurement; engine operating principles; engine components; and basic auxiliary…

76 FR 77854 - Notice of Intent To Seek Approval To Establish an Information Collection

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-14

... Reporting Requirements for the Engineering Research Centers (ERCs). OMB Number: 3145-NEW. Expiration Date of.... Abstract Proposed Project The Engineering Research Centers (ERC) program supports an integrated, interdisciplinary research environment to advance fundamental engineering knowledge and engineered systems; educate...

An Online Graduate Requirements Engineering Course

ERIC Educational Resources Information Center

Kilicay-Ergin, N.; Laplante, P. A.

2013-01-01

Requirements engineering is one of the fundamental knowledge areas in software and systems engineering graduate curricula. Recent changes in educational delivery and student demographics have created new challenges for requirements engineering education. In particular, there is an increasing demand for online education for working professionals.…

Evolution in students' understanding of thermal physics with increasing complexity

NASA Astrophysics Data System (ADS)

Langbeheim, Elon; Safran, Samuel A.; Livne, Shelly; Yerushalmi, Edit

2013-12-01

We analyze the development in students’ understanding of fundamental principles in the context of learning a current interdisciplinary research topic—soft matter—that was adapted to the level of high school students. The topic was introduced in a program for interested 11th grade high school students majoring in chemistry and/or physics, in an off-school setting. Soft matter was presented in a gradual increase in the degree of complexity of the phenomena as well as in the level of the quantitative analysis. We describe the evolution in students’ use of fundamental thermodynamics principles to reason about phase separation—a phenomenon that is ubiquitous in soft matter. In particular, we examine the impact of the use of free energy analysis, a common approach in soft matter, on the understanding of the fundamental principles of thermodynamics. The study used diagnostic questions and classroom observations to gauge the student’s learning. In order to gain insight on the aspects that shape the understanding of the basic principles, we focus on the responses and explanations of two case-study students who represent two trends of evolution in conceptual understanding in the group. We analyze changes in the two case studies’ management of conceptual resources used in their analysis of phase separation, and suggest how their prior knowledge and epistemological framing (a combination of their personal tendencies and their prior exposure to different learning styles) affect their conceptual evolution. Finally, we propose strategies to improve the instruction of these concepts.

The principles of teratology: are they still true?

PubMed

Friedman, Jan M

2010-10-01

James Wilson originally proposed a set of "Principles of Teratology" in 1959, the year before he helped to found the Teratology Society. By 1977, when these Principles were presented in a more definitive form in Wilson and Fraser's Handbook of Teratology, they had become a standard formulation of the basic tenets of the field. Wilson's Principles have continued to guide scientific research in teratology, and they are widely used in teaching. Recent advances in our knowledge of the molecular and cellular bases of embryogenesis serve only to provide a deeper understanding of the fundamental developmental mechanisms that underlie Wilson's Principles of Teratology. © 2010 Wiley-Liss, Inc.

Quantum Szilard engines with arbitrary spin.

PubMed

Zhuang, Zekun; Liang, Shi-Dong

2014-11-01

The quantum Szilard engine (QSZE) is a conceptual quantum engine for understanding the fundamental physics of quantum thermodynamics and information physics. We generalize the QSZE to an arbitrary spin case, i.e., a spin QSZE (SQSZE), and we systematically study the basic physical properties of both fermion and boson SQSZEs in a low-temperature approximation. We give the analytic formulation of the total work. For the fermion SQSZE, the work might be absorbed from the environment, and the change rate of the work with temperature exhibits periodicity and even-odd oscillation, which is a generalization of a spinless QSZE. It is interesting that the average absorbed work oscillates regularly and periodically in a large-number limit, which implies that the average absorbed work in a fermion SQSZE is neither an intensive quantity nor an extensive quantity. The phase diagrams of both fermion and boson SQSZEs give the SQSZE doing positive or negative work in the parameter space of the temperature and the particle number of the system, but they have different behaviors because the spin degrees of the fermion and the boson play different roles in their configuration states and corresponding statistical properties. The critical temperature of phase transition depends sensitively on the particle number. By using Landauer's erasure principle, we give the erasure work in a thermodynamic cycle, and we define an efficiency (we refer to it as information-work efficiency) to measure the engine's ability of utilizing information to extract work. We also give the conditions under which the maximum extracted work and highest information-work efficiencies for fermion and boson SQSZEs can be achieved.

Cooperative effect of silicon and other alloying elements on creep resistance of titanium alloys: insight from first-principles calculations

PubMed Central

Li, Yang; Chen, Yue; Liu, Jian-Rong; Hu, Qing-Miao; Yang, Rui

2016-01-01

Creep resistance is one of the key properties of titanium (Ti) alloys for high temperature applications such as in aero engines and gas turbines. It has been widely recognized that moderate addition of Si, especially when added together with some other elements (X), e.g., Mo, significantly improves the creep resistance of Ti alloys. To provide some fundamental understandings on such a cooperative effect, the interactions between Si and X in both hexagonal close-packed α and body-centered cubic β phases are systematically investigated by using a first-principles method. We show that the transition metal (TM) atoms with the number of d electrons (Nd) from 3 to 7 are attractive to Si in α phase whereas those with Nd > 8 and simple metal (SM) alloying atoms are repulsive to Si. All the alloying atoms repel Si in the β phase except for the ones with fewer d electrons than Ti. The electronic structure origin underlying the Si-X interaction is discussed based on the calculated electronic density of states and Bader charge. Our calculations suggest that the beneficial X-Si cooperative effect on the creep resistance is attributable to the strong X-Si attraction. PMID:27466045

Planck Constant Determination from Power Equivalence

NASA Astrophysics Data System (ADS)

Newell, David B.

2000-04-01

Equating mechanical to electrical power links the kilogram, the meter, and the second to the practical realizations of the ohm and the volt derived from the quantum Hall and the Josephson effects, yielding an SI determination of the Planck constant. The NIST watt balance uses this power equivalence principle, and in 1998 measured the Planck constant with a combined relative standard uncertainty of 8.7 x 10-8, the most accurate determination to date. The next generation of the NIST watt balance is now being assembled. Modification to the experimental facilities have been made to reduce the uncertainty components from vibrations and electromagnetic interference. A vacuum chamber has been installed to reduce the uncertainty components associated with performing the experiment in air. Most of the apparatus is in place and diagnostic testing of the balance should begin this year. Once a combined relative standard uncertainty of one part in 10-8 has been reached, the power equivalence principle can be used to monitor the possible drift in the artifact mass standard, the kilogram, and provide an accurate alternative definition of mass in terms of fundamental constants. *Electricity Division, Electronics and Electrical Engineering Laboratory, Technology Administration, U.S. Department of Commerce. Contribution of the National Institute of Standards and Technology, not subject to copyright in the U.S.

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

Energy Literacy: Essential Principles and Fundamental Concepts for Energy Education presents energy concepts that, if understood and applied, will help individuals and communities make informed energy decisions.

Human factors and systems engineering approach to patient safety for radiotherapy.

PubMed

Rivera, A Joy; Karsh, Ben-Tzion

2008-01-01

The traditional approach to solving patient safety problems in healthcare is to blame the last person to touch the patient. But since the publication of To Err is Human, the call has been instead to use human factors and systems engineering methods and principles to solve patient safety problems. However, an understanding of the human factors and systems engineering is lacking, and confusion remains about what it means to apply their principles. This paper provides a primer on them and their applications to patient safety.

15 CFR 734.8 - Information resulting from fundamental research.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 15 Commerce and Foreign Trade 2 2012-01-01 2012-01-01 false Information resulting from fundamental... OF THE EXPORT ADMINISTRATION REGULATIONS § 734.8 Information resulting from fundamental research. (a... applied research in science and engineering, where the resulting information is ordinarily published and...

15 CFR 734.8 - Information resulting from fundamental research.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 15 Commerce and Foreign Trade 2 2014-01-01 2014-01-01 false Information resulting from fundamental... OF THE EXPORT ADMINISTRATION REGULATIONS § 734.8 Information resulting from fundamental research. (a... applied research in science and engineering, where the resulting information is ordinarily published and...

Forensic engineering: applying materials and mechanics principles to the investigation of product failures.

PubMed

Hainsworth, S V; Fitzpatrick, M E

2007-06-01

Forensic engineering is the application of engineering principles or techniques to the investigation of materials, products, structures or components that fail or do not perform as intended. In particular, forensic engineering can involve providing solutions to forensic problems by the application of engineering science. A criminal aspect may be involved in the investigation but often the problems are related to negligence, breach of contract, or providing information needed in the redesign of a product to eliminate future failures. Forensic engineering may include the investigation of the physical causes of accidents or other sources of claims and litigation (for example, patent disputes). It involves the preparation of technical engineering reports, and may require giving testimony and providing advice to assist in the resolution of disputes affecting life or property.This paper reviews the principal methods available for the analysis of failed components and then gives examples of different component failure modes through selected case studies.

Performance and Durability of a Generator Set CI Engine using Synthetic and Petroleum Based Fuels for Military Applications

DTIC Science & Technology

2009-07-27

viable; however, better understanding of the fundamental effects of alternative fuels on engine operation is required before control strategies can be...calibrated for Diesel #2 fuel. This was not altered throughout the testing. The intake is a turbocharged -aspirated engine with a compression ratio of... Fundamentals . New York: McGraw‐ [ Hill, 1988    [2]   Noble P, McMillan D, Dabell M. Development of a Diesel‐Powered, Heavy Lift,  Amphibious  Air‐Cushion

Small Engine Repair. Two-Stroke and Four-Stroke Cycle.

ERIC Educational Resources Information Center

Hires, Bill; And Others

This curriculum guide is intended to assist persons teaching a course in repairing two- and four-stroke cycle small engines. Addressed in the individual units of instruction are the following topics: safety, tools, fasteners, and measurement techniques; basic small engine theory (engine identification and inspection, basic engine principles and…

Teaching Engineering Habits of Mind in Technology Education

ERIC Educational Resources Information Center

Loveland, Thomas; Dunn, Derrek

2014-01-01

With a new emphasis on the inclusion of engineering content and practices in technology education, attention has focused on what engineering content should be taught and assessed in technology education. The National Academy of Engineering (2010) proposed three general principles for K-12 engineering education in "Standards for K-12…

Engineering Graphics in Education: Programming and Ready Programs.

ERIC Educational Resources Information Center

Audi, M. S.

1987-01-01

Suggests a method of integrating teaching microcomputer graphics in engineering curricula without encroaching on the fundamental engineering courses. Includes examples of engineering graphics produced by commercial programs and others produced by high-level language programing in a limited credit hour segment of an educational program. (CW)

Stationary Engineering. Science Manual--2.

ERIC Educational Resources Information Center

Frost, Harold J.; Steingress, Frederick M.

This second-year student manual contains 140 brief related science lessons applying science and math to trade activities in the field of stationary engineering. The lessons are organized into 16 units: (1) Introduction to Stationary Engineering, (2) Engineering Fundamentals, (3) Steam Boilers, (4) Boiler Fittings, (5) Boilerroom System, (6)…

ThermoData Engine Database

National Institute of Standards and Technology Data Gateway

SRD 103a NIST ThermoData Engine Database (PC database for purchase)   ThermoData Engine is the first product fully implementing all major principles of the concept of dynamic data evaluation formulated at NIST/TRC.

Plans and Preliminary Results of Fundamental Studies of Ice Crystal Icing Physics in the NASA Propulsion Systems Laboratory

NASA Technical Reports Server (NTRS)

Struk, Peter; Tsao, Jen-Ching; Bartkus, Tadas

2017-01-01

This paper describes plans and preliminary results for using the NASA Propulsion Systems Lab (PSL) to experimentally study the fundamental physics of ice-crystal ice accretion. NASA is evaluating whether this facility, in addition to full-engine and motor-driven-rig tests, can be used for more fundamental ice-accretion studies that simulate the different mixed-phase icing conditions along the core flow passage of a turbo-fan engine compressor. The data from such fundamental accretion tests will be used to help develop and validate models of the accretion process. This paper presents data from some preliminary testing performed in May 2015 which examined how a mixed-phase cloud could be generated at PSL using evaporative cooling in a warmer-than-freezing environment.

Plans and Preliminary Results of Fundamental Studies of Ice Crystal Icing Physics in the NASA Propulsion Systems Laboratory

NASA Technical Reports Server (NTRS)

Struk, Peter; Tsao, Jen-Ching; Bartkus, Tadas

2016-01-01

This presentation accompanies the paper titled Plans and Preliminary Results of Fundamental Studies of Ice Crystal Icing Physics in the NASA Propulsion Systems Laboratory. NASA is evaluating whether PSL, in addition to full-engine and motor-driven-rig tests, can be used for more fundamental ice-accretion studies that simulate the different mixed-phase icing conditions along the core flow passage of a turbo-fan engine compressor. The data from such fundamental accretion tests will be used to help develop and validate models of the accretion process. This presentation (and accompanying paper) presents data from some preliminary testing performed in May 2015 which examined how a mixed-phase cloud could be generated at PSL using evaporative cooling in a warmer-than-freezing environment.

Research on the fundamental principles of China's marine invasive species prevention legislation.

PubMed

Bai, Jiayu

2014-12-15

China's coastal area is severely damaged by marine invasive species. Traditional tort theory resolves issues relevant to property damage or personal injuries, through which plaintiffs cannot cope with the ecological damage caused by marine invasive species. Several defects exist within the current legal regimes, such as imperfect management systems, insufficient unified technical standards, and unsound legal responsibility systems. It is necessary to pass legislation to prevent the ecological damage caused by marine invasive species. This investigation probes the fundamental principles needed for the administration and legislation of an improved legal framework to combat the problem of invasive species within China's coastal waters. Copyright © 2014 Elsevier Ltd. All rights reserved.

Evidence-based prosthodontics: fundamental considerations, limitations, and guidelines.

PubMed

Bidra, Avinash S

2014-01-01

Evidence-based dentistry is rapidly emerging to become an integral part of patient care, dental education, and research. Prosthodontics is a unique dental specialty that encompasses art, philosophy, and science and includes reversible and irreversible treatments. It not only affords good applicability of many principles of evidence-based dentistry but also poses numerous limitations. This article describes the epidemiologic background, fundamental considerations, scrutiny of levels of evidence, limitations, guidelines, and future perspectives of evidence-based prosthodontics. Understanding these principles can aid clinicians in appropriate appraisal of the prosthodontics literature and use the best available evidence for making confident clinical decisions and optimizing patient care. Copyright © 2014 Elsevier Inc. All rights reserved.

AUTOMOTIVE DIESEL MAINTENANCE 1. UNIT XIV, I--MAINTAINING THE AIR SYSTEM, CUMMINS DIESEL ENGINE, II--UNIT REMOVAL--TRANSMISSION.

ERIC Educational Resources Information Center

Human Engineering Inst., Cleveland, OH.

THIS MODULE OF A 30-MODULE COURSE IS DESIGNED TO DEVELOP AN UNDERSTANDING OF THE OPERATING PRINCIPLES AND MAINTENANCE OF THE DIESEL ENGINE AIR SYSTEM AND THE PROCEDURES FOR TRANSMISSION REMOVAL. TOPICS ARE (1) DEFINITION OF TERMS RELATED TO THE DIESEL AIR SYSTEM, (2) PRNCIPLES OF DIESEL AIR COMPRESSORS, (3) PRINCIPLES OF AIR STARTING MOTORS, (4)…

AUTOMOTIVE DIESEL MAINTENANCE 1, UNIT XVI, I--USE AND CARE OF SMALL HAND TOOLS, II--PRINCIPLES OF THE POWER DIVIDER.

ERIC Educational Resources Information Center

Minnesota State Dept. of Education, St. Paul. Div. of Vocational and Technical Education.

THIS MODULE OF A 30-MODULE COURSE IS DESIGNED TO DEVELOP AN UNDERSTANDING OF SMALL HAND TOOLS USED IN DIESEL ENGINE MAINTENANCE AND THE OPERATING PRINCIPLES AND MAINTENANCE OF POWER DIVIDERS (GEAR BOXES) USED IN DIESEL ENGINE POWER DISTRIBUTION. TOPICS ARE (1) UNDERSTANDING TORQUE AND HOW IT IS MEASURED, (2) REPAIRING AND REPLACING THREADED…

Schools Need Leaders--Not Managers: It's Time for a Paradigm Shift

ERIC Educational Resources Information Center

Stein, Les

2016-01-01

In the world of public school education everything depends on good leadership. Sadly, many of our schools administrators can't differentiate the difference between leading and managing; far too many of them don't know the first thing about fundamental leadership principles. In short, they don't understand the fundamentals of Mission Oriented…

CE-TOF/MS: fundamental concepts, instrumental considerations and applications.

PubMed

Staub, Aline; Schappler, Julie; Rudaz, Serge; Veuthey, Jean-Luc

2009-05-01

This review discusses the fundamental principles of TOF analyzers and covers the great progress that has been made in this area in recent years (i.e. orthogonal acceleration, reflectron). This paper also gives an overview of applications performed by CE coupled to TOF/MS detection. The main domains of interest include the analysis of biomolecules and natural compounds.

Evidence for the Fundamental Difference Hypothesis or Not?: Island Constraints Revisited

ERIC Educational Resources Information Center

Belikova, Alyona; White, Lydia

2009-01-01

This article examines how changes in linguistic theory affect the debate between the fundamental difference hypothesis and the access-to-Universal Grammar (UG) approach to SLA. With a focus on subjacency (Chomsky, 1973), a principle of UG that places constraints on "wh"-movement and that has frequently been taken as a test case for verifying…

Education of Women in Islam: A Critical Islamic Interpretation of the Quran

ERIC Educational Resources Information Center

Abukari, Abdulai

2014-01-01

In Islam, knowledge, its acquisition and application is a fundamental requirement for all Muslims to enable them to believe, think, and act according to the principles of the religion. However, differences in style of interpretation of the Qur'an have led to text being interpreted against its own fundamental worldview; an example is the…

Fundamental monogamy relation between contextuality and nonlocality.

PubMed

Kurzyński, Paweł; Cabello, Adán; Kaszlikowski, Dagomir

2014-03-14

We show that the no-disturbance principle imposes a tradeoff between locally contextual correlations violating the Klyachko-Can-Biniciogˇlu-Shumovski inequality and spatially separated correlations violating the Clauser-Horne-Shimony-Holt inequality. The violation of one inequality forbids the violation of the other. We also obtain the corresponding monogamy relation imposed by quantum theory for a qutrit-qubit system. Our results show the existence of fundamental monogamy relations between contextuality and nonlocality that suggest that entanglement might be a particular form of a more fundamental resource.

Guidelines for Engineering Teachers Concerning Educating the Engineer for Innovative and Entrepreneurial Activity.

ERIC Educational Resources Information Center

Eekels, J.

1987-01-01

Emphasizes that the concept of design is fundamental in innovation. Outlines the work of the European Society for Engineering Education-Working group on Innovation. Describes the innovation-management stream in the curriculum of the faculty of Industrial Design Engineering at Delft University of Technology, Netherlands. (CW)

Student Attraction to Engineering through Flexibility and Breadth in the Curriculum

ERIC Educational Resources Information Center

Alpay, E.

2013-01-01

Several European universities provide entry to general engineering studies prior to degree specialisation. The potential advantages of such entry include the provision of a broader foundation in engineering fundamentals, the option for students to defer specialisation until a greater awareness of the different engineering disciplines and the…

Know-how and know-why in biochemical engineering.

PubMed

von Stockar, U; Valentinotti, S; Marison, I; Cannizzaro, C; Herwig, C

2003-08-01

This contribution analyzes the position of biochemical engineering in general and bioprocess engineering particularly in the force fields between fundamental science and applications, and between academia and industry. By using culture technology as an example, it can be shown that bioprocess engineering has moved slowly but steadily from an empirical art concerned with mainly know-how to a science elucidating the know-why of culture behavior. Highly powerful monitoring tools enable biochemical engineers to understand and explain quantitatively the activity of cellular culture on a metabolic basis. Among these monitoring tools are not just semi-online analyses of culture broth by HPLC, GC and FIA, but, increasingly, also noninvasive methods such as midrange IR, Raman and capacitance spectroscopy, as well as online calorimetry. The detailed and quantitative insight into the metabolome and the fluxome that bioprocess engineers are establishing offers an unprecedented opportunity for building bridges between molecular biology and engineering biosciences. Thus, one of the major tasks of biochemical engineering sciences is not developing new know-how for industrial applications, but elucidating the know-why in biochemical engineering by conducting research on the underlying scientific fundamentals.

If I Didn't Laugh I'd Cry: An Essay on Happiness, Productivity, and the Death of Humanities Education

ERIC Educational Resources Information Center

Srigley, Ron

2012-01-01

Productivity has become the raison d'etre of Western capitalist societies, supported by its fundamental principles, quantity and impact. Both of these principles have taken hold in universities, and both place "useful" applications of knowledge above exploration of the human condition, above doubting, questioning, and wondering. The…

Assessing Students' Ability to Trace Matter in Dynamic Systems in Cell Biology

ERIC Educational Resources Information Center

Wilson, Christopher D.; Anderson, Charles W.; Heidemann, Merle; Merrill, John E.; Merritt, Brett W.; Richmond, Gail; Sibley, Duncan F.; Parker, Joyce M.

2006-01-01

College-level biology courses contain many complex processes that are often taught and learned as detailed narratives. These processes can be better understood by perceiving them as dynamic systems that are governed by common fundamental principles. Conservation of matter is such a principle, and thus tracing matter is an essential step in…

Slope across the Curriculum: Principles and Standards for School Mathematics and Common Core State Standards

ERIC Educational Resources Information Center

Nagle, Courtney; Moore-Russo, Deborah

2014-01-01

This article provides an initial comparison of the Principles and Standards for School Mathematics and the Common Core State Standards for Mathematics by examining the fundamental notion of slope. Each set of standards is analyzed using eleven previously identified conceptualizations of slope. Both sets of standards emphasize Functional Property,…

Engaging Accounting Students: How to Teach Principles of Accounting in Creative and Exciting Ways

ERIC Educational Resources Information Center

Jaijairam, Paul

2012-01-01

Many students in secondary and post-secondary institutions generally have a difficult time grasping the concepts of accounting. This article contends that it is not the subject matter that is dry, but rather the methods in which faculty have traditionally presented accounting fundamentals and principles. Departing from standard lectures and…

Findings in Experimental Psychology as Functioning Principles of Theatrical Design.

ERIC Educational Resources Information Center

Caldwell, George

A gestalt approach to theatrical design seems to provide some ready and stable explanations for a number of issues in the scenic arts. Gestalt serves as the theoretical base for a number of experiments in psychology whose findings appear to delineate the principles of art to be used in scene design. The fundamental notion of gestalt theory…

The "Difference" in Babbage's Difference Engine.

ERIC Educational Resources Information Center

Crowley, Mary L.

1985-01-01

Discoveries of Charles Babbage in the 1800s are described. Origins of the difference engine, his calculating machine, the principles of computation applied to tables, and the design and construction of his engine are included. (MNS)

Connecting Incoming Freshmen with Engineering through Hands-On Projects

ERIC Educational Resources Information Center

Cui, Suxia; Wang, Younhui; Yang, Yonggao; Nave, Felecia M.; Harris, Kendall T.

2011-01-01

Engineering programs suffer a high attrition rate, which causes the nation to graduate much less engineers. A survey of the literature reveals that the high attrition rate is due mainly to the fact that the first year of an engineering program is all fundamental theory and students don't see the connection to their future engineering careers. To…

Practical Education Support to Foster Engineers at Manufacturing and Engineering Design Center in Muroran Institute of Technology

NASA Astrophysics Data System (ADS)

Kazama, Toshiharu; Hanajima, Naohiko; Shimizu, Kazumichi; Satoh, Kohki

To foster engineers with creative power, Muroran Institute of Technology established Manufacturing and Engineering Design Center (MEDeC) that concentrates on Monozukuri. MEDeC consists of three project groups : i) Education Support Group provides educational support for practical training classes on and off campus and PDCA (plan-do-check-action) -conscious engineering design education related to Monozukuri ; ii) Fundamental Manufacturing Research Group carries out nurture research into fundamental and innovative technology of machining and manufacturing, and iii) Regional Cooperation Group coordinates the activities in cooperation with bureau, schools and industries in and around Muroran City. MEDeC has a fully integrated collection of machine tools and hand tools for manufacturing, an atelier, a tatara workplace, implements for measurement and related equipment designed for practically teaching state-of-the-practice manufacturing methods.

Engineering cells for cell culture bioprocessing--physiological fundamentals.

PubMed

Seth, Gargi; Hossler, Patrick; Yee, Joon Chong; Hu, Wei-Shou

2006-01-01

In the past decade, we have witnessed a tremendous increase in the number of mammalian cell-derived therapeutic proteins with clinical applications. The success of making these life-saving biologics available to the public is partly due to engineering efforts to enhance process efficiency. To further improve productivity, much effort has been devoted to developing metabolically engineered producing cells, which possess characteristics favorable for large-scale bioprocessing. In this article we discuss the fundamental physiological basis for cell engineering. Different facets of cellular mechanisms, including metabolism, protein processing, and the balancing pathways of cell growth and apoptosis, contribute to the complex traits of favorable growth and production characteristics. We present our assessment of the current state of the art by surveying efforts that have already been undertaken in engineering cells for a more robust process. The concept of physiological homeostasis as a key determinant and its implications on cell engineering is emphasized. Integrating the physiological perspective with cell culture engineering will facilitate attainment of dream cells with superlative characteristics.

Compatible Spatial Discretizations for Partial Differential Equations

DOE Office of Scientific and Technical Information (OSTI.GOV)

Arnold, Douglas, N, ed.

From May 11--15, 2004, the Institute for Mathematics and its Applications held a hot topics workshop on Compatible Spatial Discretizations for Partial Differential Equations. The numerical solution of partial differential equations (PDE) is a fundamental task in science and engineering. The goal of the workshop was to bring together a spectrum of scientists at the forefront of the research in the numerical solution of PDEs to discuss compatible spatial discretizations. We define compatible spatial discretizations as those that inherit or mimic fundamental properties of the PDE such as topology, conservation, symmetries, and positivity structures and maximum principles. A wide varietymore » of discretization methods applied across a wide range of scientific and engineering applications have been designed to or found to inherit or mimic intrinsic spatial structure and reproduce fundamental properties of the solution of the continuous PDE model at the finite dimensional level. A profusion of such methods and concepts relevant to understanding them have been developed and explored: mixed finite element methods, mimetic finite differences, support operator methods, control volume methods, discrete differential forms, Whitney forms, conservative differencing, discrete Hodge operators, discrete Helmholtz decomposition, finite integration techniques, staggered grid and dual grid methods, etc. This workshop seeks to foster communication among the diverse groups of researchers designing, applying, and studying such methods as well as researchers involved in practical solution of large scale problems that may benefit from advancements in such discretizations; to help elucidate the relations between the different methods and concepts; and to generally advance our understanding in the area of compatible spatial discretization methods for PDE. Particular points of emphasis included: + Identification of intrinsic properties of PDE models that are critical for the fidelity of numerical simulations. + Identification and design of compatible spatial discretizations of PDEs, their classification, analysis, and relations. + Relationships between different compatible spatial discretization methods and concepts which have been developed; + Impact of compatible spatial discretizations upon physical fidelity, verification and validation of simulations, especially in large-scale, multiphysics settings. + How solvers address the demands placed upon them by compatible spatial discretizations. This report provides information about the program and abstracts of all the presentations.« less

Protein Engineering: Case Studies of Commercialized Engineered Products

ERIC Educational Resources Information Center

Walsh, Gary

2007-01-01

Programs in biochemistry invariably encompass the principles of protein engineering. Students often display increased understanding and enthusiasm when theoretical concepts are underpinned by practical example. Herein are presented five case studies, each focusing upon a commercial protein product engineered to enhance its application-relevant…

3 CFR - Regulatory Review

Code of Federal Regulations, 2010 CFR

2010-01-01

... of regulatory tools such as warnings, disclosure requirements, public education, and economic... review. In this time of fundamental transformation, that process—and the principles governing regulation...

Argonne Chemical Sciences & Engineering - Awards Home

Science.gov Websites

Argonne National Laboratory Chemical Sciences & Engineering DOE Logo CSE Home About CSE Argonne Home > Chemical Sciences & Engineering > Fundamental Interactions Catalysis & Energy Computational Postdoctoral Fellowships Contact Us CSE Intranet Awards Argonne's Chemical Sciences and

THERMODYNAMICS USED IN ENVIRONMENTAL ENGINEERING

EPA Science Inventory

Thermodynamics is a science in which energy transformations are studied as well as their relationships to the changes in the chemical properties of a system. It is the fundamental basis of many engineering fields. The profession of environmental engineering is no exception. In pa...

77 FR 9272 - Agency Information Collection Activities: Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-16

... Engineering Research Centers (ERCs). OMB Number: 3145-New. Type of Request: Intent to seek approval to establish an information collection. Abstract: Proposed Project: The Engineering Research Centers (ERC) program supports an integrated, interdisciplinary research environment to advance fundamental engineering...

Leadership in Government Organization Change Efforts: A Multi-Case Analysis

DTIC Science & Technology

2004-09-01

cleared contractor employees on short notice, in the event of demand surges. Letting go of contractor employees was considered a safer bet than...principle can be seen in the early establishment of two reactor plant-engineering laboratories. The strong, competitive capabilities of these two...personnel. The list could extend indefinitely. Application of this principle can be seen in the early establishment of two reactor plant-engineering

Katherine J. Chou | NREL

Science.gov Websites

J. Chou Photo of Katherine J. Chou Katherine Chou Microbial Physiology & Engineering , Clostridium thermocellum, through metabolic engineering. "Biological Electron Transfer and Catalysis principles governing substrate utilization. "Advance Biofuels from Cellulose via Genetic Engineering of

48 CFR 31.201-7 - Construction and architect-engineer contracts.

Code of Federal Regulations, 2010 CFR

2010-10-01

...-engineer contracts. 31.201-7 Section 31.201-7 Federal Acquisition Regulations System FEDERAL ACQUISITION... Organizations 31.201-7 Construction and architect-engineer contracts. Specific principles and procedures for... architect-engineer contracts related to construction projects, are in 31.105. The applicability of these...

48 CFR 31.201-7 - Construction and architect-engineer contracts.

Code of Federal Regulations, 2012 CFR

2012-10-01

...-engineer contracts. 31.201-7 Section 31.201-7 Federal Acquisition Regulations System FEDERAL ACQUISITION... Organizations 31.201-7 Construction and architect-engineer contracts. Specific principles and procedures for... architect-engineer contracts related to construction projects, are in 31.105. The applicability of these...

48 CFR 31.201-7 - Construction and architect-engineer contracts.

Code of Federal Regulations, 2014 CFR

2014-10-01

...-engineer contracts. 31.201-7 Section 31.201-7 Federal Acquisition Regulations System FEDERAL ACQUISITION... Organizations 31.201-7 Construction and architect-engineer contracts. Specific principles and procedures for... architect-engineer contracts related to construction projects, are in 31.105. The applicability of these...

48 CFR 31.201-7 - Construction and architect-engineer contracts.

Code of Federal Regulations, 2013 CFR

2013-10-01

...-engineer contracts. 31.201-7 Section 31.201-7 Federal Acquisition Regulations System FEDERAL ACQUISITION... Organizations 31.201-7 Construction and architect-engineer contracts. Specific principles and procedures for... architect-engineer contracts related to construction projects, are in 31.105. The applicability of these...

48 CFR 31.201-7 - Construction and architect-engineer contracts.

Code of Federal Regulations, 2011 CFR

2011-10-01

...-engineer contracts. 31.201-7 Section 31.201-7 Federal Acquisition Regulations System FEDERAL ACQUISITION... Organizations 31.201-7 Construction and architect-engineer contracts. Specific principles and procedures for... architect-engineer contracts related to construction projects, are in 31.105. The applicability of these...

EIT Course via Statewide TV

ERIC Educational Resources Information Center

Marstrander, Jan H.; Talbot, Thomas F.

1975-01-01

Discusses the television broadcasting of a refresher course in mathematics and engineering fundamentals for those preparing to take the Engineer-in-Training (EIT) State Board Examination in Alabama. (MLH)

[Biological reductionism and the medicine of the 21st century].

PubMed

Sverdlov, E D

2010-01-01

They were bothered by the fact that biological science, which was focusing on individual parts of the living systems in the hope that their knowledge should help understand the organization and principles of the living systems' existence, would be at a deadlock sooner or later. The development of fundamental molecular sciences proves them to be actually in a crisis. I would like to show, in this review, that the elevated expectations of a radical revolution in the field of fundamental biological sciences and in applied spheres, particularly, in practical medicine, which are due to the progress of high-effective technologies of the cell's molecular organization, especially the technologies designed for the sequencing of entire genomes, do not prove valid. These technologies cause the accumulation of vast amounts of information with no functional interpretation done. It starts to be comprehensible now that we advance at a painfully slow step to some successive stage on the path towards the answer to the essential question of biology -- What is Life? Moreover, understanding forms that we are advancing, equally slowly and painfully, along the path of progress in the field of medicine, especially so when it concerns the widely spread diseases, which are complex diseases. On this path, we often find ourselves at impasses with no way out, and although we witness the birth of a new biology -- the system biology, a synthetic one, constituting a unique alloy of many sciences, it is far from being definite that this new biology wouldalso answer this principal fundamental question and push forward the medical applications of genomics. Nonetheless, the accumulated information is very helpful and can be used for the elaboration of fundamental vetoes of biology [1] which will allow a considerable portion of the efforts in the practical, namely medical, area to be rejected as unrealizable, in the same way as the second principle of thermodynamics puts a ban on the creation of the perpetuum mobile. I am also trying to postulate that in the area of practice one should possibly think about the approaches directed to the eradication or substitution of ill cells or a damaged system's tissues, and not about the reductionistic approaches aimed at repairing the diseased organism's individual molecular components. I tried to demonstrate this statement using the example of cancer genetic surgerys. Employment of stem cells, including those modified by gene engineering, provides another instance of a holistic approach.

Piezoelectric Film.

ERIC Educational Resources Information Center

Garrison, Steve

1992-01-01

Presents activities that utilize piezoelectric film to familiarize students with fundamental principles of electricity. Describes classroom projects involving chemical sensors, microbalances, microphones, switches, infrared sensors, and power generation. (MDH)

Applying design principles to fusion reactor configurations for propulsion in space

NASA Technical Reports Server (NTRS)

Carpenter, Scott A.; Deveny, Marc E.; Schulze, Norman R.

1993-01-01

The application of fusion power to space propulsion requires rethinking the engineering-design solution to controlled-fusion energy. Whereas the unit cost of electricity (COE) drives the engineering-design solution for utility-based fusion reactor configurations; initial mass to low earth orbit (IMLEO), specific jet power (kW(thrust)/kg(engine)), and reusability drive the engineering-design solution for successful application of fusion power to space propulsion. We applied three design principles (DP's) to adapt and optimize three candidate-terrestrial-fusion-reactor configurations for propulsion in space. The three design principles are: provide maximum direct access to space for waste radiation, operate components as passive radiators to minimize cooling-system mass, and optimize the plasma fuel, fuel mix, and temperature for best specific jet power. The three candidate terrestrial fusion reactor configurations are: the thermal barrier tandem mirror (TBTM), field reversed mirror (FRM), and levitated dipole field (LDF). The resulting three candidate space fusion propulsion systems have their IMLEO minimized and their specific jet power and reusability maximized. We performed a preliminary rating of these configurations and concluded that the leading engineering-design solution to space fusion propulsion is a modified TBTM that we call the Mirror Fusion Propulsion System (MFPS).

Health care professional workstation: software system construction using DSSA scenario-based engineering process.

PubMed

Hufnagel, S; Harbison, K; Silva, J; Mettala, E

1994-01-01

This paper describes a new method for the evolutionary determination of user requirements and system specifications called scenario-based engineering process (SEP). Health care professional workstations are critical components of large scale health care system architectures. We suggest that domain-specific software architectures (DSSAs) be used to specify standard interfaces and protocols for reusable software components throughout those architectures, including workstations. We encourage the use of engineering principles and abstraction mechanisms. Engineering principles are flexible guidelines, adaptable to particular situations. Abstraction mechanisms are simplifications for management of complexity. We recommend object-oriented design principles, graphical structural specifications, and formal components' behavioral specifications. We give an ambulatory care scenario and associated models to demonstrate SEP. The scenario uses health care terminology and gives patients' and health care providers' system views. Our goal is to have a threefold benefit. (i) Scenario view abstractions provide consistent interdisciplinary communications. (ii) Hierarchical object-oriented structures provide useful abstractions for reuse, understandability, and long term evolution. (iii) SEP and health care DSSA integration into computer aided software engineering (CASE) environments. These environments should support rapid construction and certification of individualized systems, from reuse libraries.

Investigation of the fundamentals of low-energy nanosecond pulse ignition: Final CRADA Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wallner, Thomas; Scarcelli, Riccardo; Zhang, Anqi

A detailed investigation of the fundamentals of low-energy nanosecond pulse ignition was performed with the objective to overcome the barrier presented by limited knowledge and characterization of nonequilibrium plasma ignition for realistic internal combustion engine applications (be it in the automotive or power generation field) and shed light on the mechanisms which improve the performance of the advanced TPS ignition system compared to conventional state-of-the-art hardware. Three main tasks of the research included experimental evaluation on a single-cylinder automotive gasoline engine, experimental evaluation on a single-cylinder stationary natural gas engine and energy quantification using x-ray diagnostics.

[Integration of fundamental and applied medical and technical research made at the department of the biomedical systems, Moscow State Institute of Electronic Engineering].

PubMed

Selishchev, S V

2004-01-01

The integration results of fundamental and applied medical-and-technical research made at the chair of biomedical systems, Moscow state institute of electronic engineering (technical university--MSIEE), are described in the paper. The chair is guided in its research activity by the traditions of higher education in Russia in the field of biomedical electronics and biomedical engineering. Its activities are based on the extrapolation of methods of electronic tools, computer technologies, physics, biology and medicine with due respect being paid to the requirements of practical medicine and to topical issues of research and design.

Theoretical Studies of Small-System Thermodynamics in Energetic Materials

DTIC Science & Technology

2016-01-06

SECURITY CLASSIFICATION OF: This is a comprehensive theoretical research program to investigate the fundamental principles of small-system thermodynamics ...a.k.a. nanothermodynamics). The proposed work is motivated by our desire to better understand the fundamental dynamics and thermodynamics of...for Public Release; Distribution Unlimited Final Report: Theoretical Studies of Small-System Thermodynamics in Energetic Materials The views, opinions

Can Grade-6 Students Understand Quarks? Probing Acceptance of the Subatomic Structure of Matter with 12-Year-Olds

ERIC Educational Resources Information Center

Wiener, Gerfried J.; Schmeling, Sascha M.; Hopf, Martin

2015-01-01

This study introduces a teaching concept based on the Standard Model of particle physics. It comprises two consecutive chapters--elementary particles and fundamental interactions. The rationale of this concept is that the fundamental principles of particle physics can run as the golden thread through the whole physics curriculum. The design…

[Islam and caring].

PubMed

Nadir, Sihem

2015-10-01

There are more and more followers of the Muslim religion in France. All caregivers need to understand the fundamental principles that their Muslim patients hold sacred in the area of health and care. For Muslims, it is of utmost importance to observe the fundamentals of Islam and the values of brotherhood, tolerance, fairness and truth are essential. Copyright © 2015 Elsevier Masson SAS. All rights reserved.

Containing Revolutionary Islam: Reassessing the Problem and the Approach

DTIC Science & Technology

2017-03-01

2011), xx. 83 Russ Rodgers, Fundamentals of Islamic Asymmetric Warfare: A Documentary Analysis of the Principles of Muhammad (Lewiston, NY: Edwin...have not yet effectively coalesced or managed to spark the greater revolution they seek. They remain fragmented, choosing divergent activities in...Libertarian Rebuttal. Auburn, AL: Ludwig von Mises Institute, 2015. Rodgers, Russ. Fundamentals of Islamic Asymmetric Warfare: A Documentary Analysis

Determination of a Predictive Model for the Fundamentals of Engineering Examination

ERIC Educational Resources Information Center

Wheeler, Edward W.

2012-01-01

In early 1995, the University of Tennessee at Martin (UTM) sought permission to terminate three existing engineering technology degree programs and replace them with a single Bachelor of Science in Engineering (BSE) degree. As part of the requirements to proceed with the implementation of an engineering program, the University of Tennessee system…

Mountain Plains Learning Experience Guide: Automotive Repair. Course: Engine Repair.

ERIC Educational Resources Information Center

Schramm, C.; Osland, Walt

One of twelve individualized courses included in an automotive repair curriculum, this course covers theory and construction, inspection diagnoses, and service and overhaul of automotive engines. The course is comprised of five units: (1) Fundamentals of Four-Cycle Engines, (2) Engine Construction, (3) Valve Train, (4) Lubricating Systems, and (5)…

Student Opinions and Perceptions of Undergraduate Thermodynamics Courses in Engineering

ERIC Educational Resources Information Center

Ugursal, V. Ismet; Cruickshank, Cynthia A.

2015-01-01

Thermodynamics is a fundamental foundation of all engineering disciplines. A vast majority of engineering undergraduate programmes contain one or more courses on thermodynamics, and many engineers use thermodynamics every day to analyse or design energy systems. However, there is extensive anecdotal evidence as well as a wide range of published…

The Revolt of the Engineers. Social Responsibility and the American Engineering Profession.

ERIC Educational Resources Information Center

Layton, Edwin T., Jr.

In examining the history of American engineering, this book emphasizes professionalism, social responsibility, and ethics. It explains how some engineers have attempted to express a concern for the social effects of technology and to forge codes of ethics which could articulate the profession's fundamental obligation to the public. The document's…

STEP and fundamental physics

NASA Astrophysics Data System (ADS)

Overduin, James; Everitt, Francis; Worden, Paul; Mester, John

2012-09-01

The Satellite Test of the Equivalence Principle (STEP) will advance experimental limits on violations of Einstein's equivalence principle from their present sensitivity of two parts in 1013 to one part in 1018 through multiple comparison of the motions of four pairs of test masses of different compositions in a drag-free earth-orbiting satellite. We describe the experiment, its current status and its potential implications for fundamental physics. Equivalence is at the heart of general relativity, our governing theory of gravity and violations are expected in most attempts to unify this theory with the other fundamental interactions of physics, as well as in many theoretical explanations for the phenomenon of dark energy in cosmology. Detection of such a violation would be equivalent to the discovery of a new force of nature. A null result would be almost as profound, pushing upper limits on any coupling between standard-model fields and the new light degrees of freedom generically predicted by these theories down to unnaturally small levels.

How Much Do Engineering Students Know about Sustainable Development? The Findings of an International Survey and Possible Implications for the Engineering Curriculum

ERIC Educational Resources Information Center

Azapagic, Adisa; Perdan, Slobodan; Shallcross, David

2005-01-01

This paper addresses the issue of engineering education for sustainable development. In an attempt to facilitate a better integration of sustainability teaching into the engineering curriculum, it seeks to provide answers to the following fundamental questions: (1) How much do engineering students know about sustainable development? (2) What are…

Life with Four Billion Atoms

DOE Office of Scientific and Technical Information (OSTI.GOV)

Knight, Thomas

2013-04-10

Today it is commonplace to design and construct single silicon chips with billions of transistors. These are complex systems, difficult (but possible) to design, test, and fabricate. Remarkably, simple living systems can be assembled from a similar number of atoms, most of them in water molecules. In this talk I will present the current status of our attempts at full understanding and complexity reduction of one of the simplest living systems, the free-living bacterial species Mesoplasma florum. This 400 nm diameter cell thrives and replicates every 40 minutes with a genome of only 800 kilobases. Our recent experiments using transposonmore » gene knockouts identified 354 of 683 annotated genes as inessential in laboratory culture when inactivated individually. While a functional redesigned genome will certainly not remove all of those genes, this suggests that roughly half the genome can be removed in an intentional redesign. I will discuss our recent knockout results and methodology, and our future plans for Genome re-engineering using targeted knock-in/knock-out double recombination; whole cell metabolic models; comprehensive whole cell metabolite measurement techniques; creation of plug-and-play metabolic modules for the simplified organism; inherent and engineered biosafety control mechanisms. This redesign is part of a comprehensive plan to lay the foundations for a new discipline of engineering biology. Engineering biological systems requires a fundamentally different viewpoint from that taken by the science of biology. Key engineering principles of modularity, simplicity, separation of concerns, abstraction, flexibility, hierarchical design, isolation, and standardization are of critical importance. The essence of engineering is the ability to imagine, design, model, build, and characterize novel systems to achieve specific goals. Current tools and components for these tasks are primitive. Our approach is to create and distribute standard biological parts, organisms, assembly techniques, and measurement techniques as a way of enabling this new field.« less

Report of the Polymer Core Course Committee: Polymer Principles for the Chemical Engineering Curriculum.

ERIC Educational Resources Information Center

Journal of Chemical Education, 1985

1985-01-01

Offers suggestions for introducing polymer topics into: (1) introductory chemical engineering; (2) transport phenomena and unit operations; (3) chemical engineering thermodynamics; and (4) reaction engineering. Also included for each area are examples of textbooks in current use and a few typical problems. (JN)

41 CFR 102-80.135 - Who is a qualified fire protection engineer?

Code of Federal Regulations, 2010 CFR

2010-07-01

... protection engineer? 102-80.135 Section 102-80.135 Public Contracts and Property Management Federal Property... qualified fire protection engineer? A qualified fire protection engineer is defined as an individual with a thorough knowledge and understanding of the principles of physics and chemistry governing fire growth...

Program (systems) engineering

NASA Technical Reports Server (NTRS)

Baroff, Lynn E.; Easter, Robert W.; Pomphrey, Richard B.

2004-01-01

Program Systems Engineering applies the principles of Systems Engineering at the program level. Space programs are composed of interrelated elements which can include collections of projects, advanced technologies, information systems, etc. Some program elements are outside traditional engineering's physical systems, such as education and public outreach, public relations, resource flow, and interactions within the political environments.

A Contemporary Preservice Technology Education Program

ERIC Educational Resources Information Center

Flanigan, Rod; Becker, Kurt; Stewardson, Gary

2012-01-01

In order to teach engineering education, today's engineering and technology education teachers must be equipped with lesson plans to teach engineering design, among other principles, to the 6th-12th grade levels. At Utah State University (USU), curriculum has been developed for preservice engineering and technology education teachers that…

Consistent Quantum Theory

NASA Astrophysics Data System (ADS)

Griffiths, Robert B.

2001-11-01

Quantum mechanics is one of the most fundamental yet difficult subjects in physics. Nonrelativistic quantum theory is presented here in a clear and systematic fashion, integrating Born's probabilistic interpretation with Schrödinger dynamics. Basic quantum principles are illustrated with simple examples requiring no mathematics beyond linear algebra and elementary probability theory. The quantum measurement process is consistently analyzed using fundamental quantum principles without referring to measurement. These same principles are used to resolve several of the paradoxes that have long perplexed physicists, including the double slit and Schrödinger's cat. The consistent histories formalism used here was first introduced by the author, and extended by M. Gell-Mann, J. Hartle and R. Omnès. Essential for researchers yet accessible to advanced undergraduate students in physics, chemistry, mathematics, and computer science, this book is supplementary to standard textbooks. It will also be of interest to physicists and philosophers working on the foundations of quantum mechanics. Comprehensive account Written by one of the main figures in the field Paperback edition of successful work on philosophy of quantum mechanics

40 CFR 63.526 - Monitoring requirements.

Code of Federal Regulations, 2012 CFR

2012-07-01

... vent. (D) Design analysis based on accepted chemical engineering principles, measurable process.... (i) For the purpose of determining de minimis status for emission points, engineering assessment may... operating conditions expected to yield the highest flow rate and concentration. Engineering assessment...

40 CFR 63.526 - Monitoring requirements.

Code of Federal Regulations, 2013 CFR

2013-07-01

... vent. (D) Design analysis based on accepted chemical engineering principles, measurable process.... (i) For the purpose of determining de minimis status for emission points, engineering assessment may... operating conditions expected to yield the highest flow rate and concentration. Engineering assessment...

40 CFR 63.526 - Monitoring requirements.

Code of Federal Regulations, 2014 CFR

2014-07-01

... vent. (D) Design analysis based on accepted chemical engineering principles, measurable process.... (i) For the purpose of determining de minimis status for emission points, engineering assessment may... operating conditions expected to yield the highest flow rate and concentration. Engineering assessment...

Nuclear Technology. Course 32: Nondestructive Examination (NDE) II. Module 32-3, Fundamentals of Magnetic Particle Testing.

ERIC Educational Resources Information Center

Groseclose, Richard

This third in a series of six modules for a course titled Nondestructive Examination (NDE) Techniques II explains the principles of magnets and magnetic fields and how they are applied in magnetic particle testing, describes the theory and methods of magnetizing test specimens, describes the test equipment used, discusses the principles and…

A Brief Statement on Educational Principle of the People's Republic of China

ERIC Educational Resources Information Center

Yang, Tianping

2005-01-01

China issued two educational principles in 1960s and 1990s respectively. Both are composed of three fundamental elements--general aim of education, concrete purposes of education and ways of realizing them. Both emphasize the combination of education and work as well as the all-round development of the educatee. The difference between the two is…

Ethics in oncology: principles and responsibilities declared in the Italian Ragusa statement.

PubMed

Gori, Stefania; Pinto, Carmine; Caminiti, Caterina; Aprile, Giuseppe; Marchetti, Paolo; Perrone, Francesco; Di Maio, Massimo; Omodeo Salè, Emanuela; Mancuso, Annamaria; De Cicco, Maurizio; Di Costanzo, Francesco; Crispino, Sergio; Passalacqua, Rodolfo; Merlano, Marco; Zagonel, Vittorina; Fioretto, Luisa; Micallo, Giovanni; Labianca, Roberto; Bordonaro, Roberto; Comandone, Alessandro; Spinsanti, Sandro; Iacono, Carmelo; Nicolis, Fabrizio

2016-12-01

Cancer care involves many ethical issues. The need for more patient-centered healthcare together with the improved empowerment of every person diagnosed with cancer have been transposed by the Italian Association of Medical Oncology (AIOM) and eventually translated in the Ragusa statement. This position paper describes the philosophy that lies beneath this document and its fundamental principles.

Integrating Research on How People Learn and Learning across Settings as a Window of Opportunity to Address Inequality in Educational Processes and Outcomes

ERIC Educational Resources Information Center

Lee, Carol D.

2017-01-01

This chapter addresses how fundamental principles regarding how people learn in the last decade open up possibilities for conceptualizing a broad ecological culturally rooted framework for the design of robust learning environments in a variety of settings, especially schools. These cross-disciplinary principles emerging from across relevant…

Team-Based Learning Practices and Principles in Comparison with Cooperative Learning and Problem-Based Learning

ERIC Educational Resources Information Center

Michaelsen, Larry K.; Davidson, Neil; Major, Claire Howell

2014-01-01

The authors address three questions: (1) What are the foundational practices of team-based learning (TBL)? (2) What are the fundamental principles underlying TBL's foundational practices? and (3) In what ways are TBL's foundational practices similar to and/or different from the practices employed by problem-based learning (PBL) and…

The potential of legislation on organ donation to increase the supply of donor organs.

PubMed

Coppen, Remco; Friele, Roland D; van der Zee, Jouke; Gevers, Sjef K

2010-12-01

The aim of this paper is to assess the possibilities to adapt the 1998 Dutch Organ Donation Act, taking account of fundamental principles such as the right to physical integrity, equitable access to and equal availability of care, and the non-commerciality principle, with a view to increasing the organ supply. In 2008 the Dutch Taskforce on Organ Donation presented several proposals to amend the Act and to increase the supply of organs. This paper describes the proposals to amend the Act and evaluates them by assessing their intrinsic adherence to basic principles and the available evidence that these proposals will indeed increase the organ supply. Several proposals could constitute an infringement of fundamental principles of the Act. Moreover, evidence for their impact on the organ supply is lacking. Changing the consent system is possible, as this would not incur legal objections. There are diverging views regarding the impact of consent systems on the organ supply. The scope for changing the Act and its impact on organ procurement is at best limited. Relying on legislation alone will possibly not bring much relief, whereas additional policy measures may be more successful. Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.

Development and integration of a scalable low NOx combustion chamber for a hydrogen-fueled aerogas turbine

NASA Astrophysics Data System (ADS)

Boerner, S.; Funke, H. H.-W.; Hendrick, P.; Recker, E.; Elsing, R.

2013-03-01

The usage of alternative fuels in aircraft industry plays an important role of current aero engine research and development processes. The micromix burning principle allows a secure and low NOx combustion of gaseous hydrogen. The combustion principle is based on the fluid phenomenon of jet in cross flow and achieves a significant lowering in NOx formation by using multiple miniaturized flames. The paper highlights the development and the integration of a combustion chamber, based on the micromix combustion principle, into an Auxiliary Power Unit (APU) GTCP 36-300 with regard to the necessary modifications on the gas turbine and on the engine controller.

Understanding fuel anti-knock performances in modern SI engines using fundamental HCCI experiments

DOE PAGES

Yang, Yi; Dec, John E.; Sjoberg, Magnus; ...

2015-08-19

Modern spark-ignition (SI) engine technologies have considerably changed in-cylinder conditions under which fuel autoignition and engine knock take place. In this paper, fundamental HCCI engine experiments are proposed as a means for characterizing the impact of these technologies on the knock propensity of different fuels. In particular, the impacts of turbocharging, direct injection (DI), and downspeeding on operation with ethanol and gasoline are investigated to demonstrate this approach. Results reported earlier for ethanol and gasoline on HCCI combustion are revisited with the new perspective of how their autoignition characteristics fit into the anti-knock requirement in modern SI engines. For example,more » the weak sensitivity to pressure boost demonstrated by ethanol in HCCI autoignition can be used to explain the strong knock resistance of ethanol fuels for turbocharged SI engines. Further, ethanol's high sensitivity to charge temperature makes charge cooling, which can be produced by fuel vaporization via direct injection or by piston expansion via spark-timing retard, very effective for inhibiting knock. On the other hand, gasoline autoignition shows a higher sensitivity to pressure, so only very low pressure boost can be applied before knock occurs. Gasoline also demonstrates low temperature sensitivity, so it is unable to make as effective use of the charge cooling produced by fuel vaporization or spark retard. These arguments comprehensively explain literature results on ethanol's substantially better anti-knock performance over gasoline in modern turbocharged DISI engines. Fundamental HCCI experiments such as these can thus be used as a diagnostic and predictive tool for knock-limited SI engine performance for various fuels. As a result, examples are presented where HCCI experiments are used to identify biofuel compounds with good potential for modern SI-engine applications.« less

Darwinian demons, evolutionary complexity, and information maximization.

PubMed

Krakauer, David C

2011-09-01

Natural selection is shown to be an extended instance of a Maxwell's demon device. A demonic selection principle is introduced that states that organisms cannot exceed the complexity of their selective environment. Thermodynamic constraints on error repair impose a fundamental limit to the rate that information can be transferred from the environment (via the selective demon) to the genome. Evolved mechanisms of learning and inference can overcome this limitation, but remain subject to the same fundamental constraint, such that plastic behaviors cannot exceed the complexity of reward signals. A natural measure of evolutionary complexity is provided by mutual information, and niche construction activity--the organismal contribution to the construction of selection pressures--might in principle lead to its increase, bounded by thermodynamic free energy required for error correction.

Fundamentals of Geophysics

NASA Astrophysics Data System (ADS)

Lowrie, William

1997-10-01

This unique textbook presents a comprehensive overview of the fundamental principles of geophysics. Unlike most geophysics textbooks, it combines both the applied and theoretical aspects to the subject. The author explains complex geophysical concepts using abundant diagrams, a simplified mathematical treatment, and easy-to-follow equations. After placing the Earth in the context of the solar system, he describes each major branch of geophysics: gravitation, seismology, dating, thermal and electrical properties, geomagnetism, paleomagnetism and geodynamics. Each chapter begins with a summary of the basic physical principles, and a brief account of each topic's historical evolution. The book will satisfy the needs of intermediate-level earth science students from a variety of backgrounds, while at the same time preparing geophysics majors for continued study at a higher level.

Federal truck size and weight policy : looking beyond the comprehensive truck size and weight study : Irvine, California, May 10-11, 2000

DOT National Transportation Integrated Search

1997-05-01

This document presents a series of five design examples illustrating the principles and methods of geotechnical earthquake engineering and seismic design for highway facilities. These principles and methods are described in Volume I - Design Principl...

A Review on Development and Applications of Bio-Inspired Superhydrophobic Textiles

PubMed Central

Ahmad, Ishaq; Kan, Chi-wai

2016-01-01

Bio-inspired engineering has been envisioned in a wide array of applications. All living bodies on Earth, including animals and plants, have well organized functional systems developed by nature. These naturally designed functional systems inspire scientists and engineers worldwide to mimic the system for practical applications by human beings. Researchers in the academic world and industries have been trying, for hundreds of years, to demonstrate how these natural phenomena could be translated into the real world to save lives, money and time. One of the most fascinating natural phenomena is the resistance of living bodies to contamination by dust and other pollutants, thus termed as self-cleaning phenomenon. This phenomenon has been observed in many plants, animals and insects and is termed as the Lotus Effect. With advancement in research and technology, attention has been given to the exploration of the underlying mechanisms of water repellency and self-cleaning. As a result, various concepts have been developed including Young’s equation, and Wenzel and Cassie–Baxter theories. The more we unravel this process, the more we get access to its implications and applications. A similar pursuit is emphasized in this review to explain the fundamental principles, mechanisms, past experimental approaches and ongoing research in the development of bio-inspired superhydrophobic textiles. PMID:28774012

First-year Engineering Education with the Creative Electrical Engineering Laboratory

NASA Astrophysics Data System (ADS)

Tsukamoto, Takehiko; Sugito, Tetsumasa; Ozeki, Osamu; Ushiroda, Sumio

The Department of Electrical and Electronic Engineering in Toyota National College of Technology has put great emphasis on fundamental subjects. We introduced the creative electrical engineering laboratory into the first-year engineering education since 1998. The laboratory concentrates on the practice exercise. The final questionnaire of students showed that our first-year education is very effective to promote students motivation and their scholastic ability in engineering.

The maximum efficiency of nano heat engines depends on more than temperature

NASA Astrophysics Data System (ADS)

Woods, Mischa; Ng, Nelly; Wehner, Stephanie

Sadi Carnot's theorem regarding the maximum efficiency of heat engines is considered to be of fundamental importance in the theory of heat engines and thermodynamics. Here, we show that at the nano and quantum scale, this law needs to be revised in the sense that more information about the bath other than its temperature is required to decide whether maximum efficiency can be achieved. In particular, we derive new fundamental limitations of the efficiency of heat engines at the nano and quantum scale that show that the Carnot efficiency can only be achieved under special circumstances, and we derive a new maximum efficiency for others. A preprint can be found here arXiv:1506.02322 [quant-ph] Singapore's MOE Tier 3A Grant & STW, Netherlands.

The Development of Ada (Trademark) Software for Secure Environments

DTIC Science & Technology

1986-05-23

Telecommunications environment, This paper discusses software socurity and seeks to demostrate how the Ada programming language can be utilizec as a tool...complexity 4 . We use abstraction in our lives every day to control complexity; the principles of abstraction for software engineering are ro different...systems. These features directly sup,) )-t t.ie m odernp software engineering principles d1 s I , , 1 t, thne previous section. This is not surprising

Quantitatively probing propensity for structural transitions in engineered virus nanoparticles by single-molecule mechanical analysis

NASA Astrophysics Data System (ADS)

Castellanos, Milagros; Carrillo, Pablo J. P.; Mateu, Mauricio G.

2015-03-01

Viruses are increasingly being studied from the perspective of fundamental physics at the nanoscale as biologically evolved nanodevices with many technological applications. In viral particles of the minute virus of mice (MVM), folded segments of the single-stranded DNA genome are bound to the capsid inner wall and act as molecular buttresses that increase locally the mechanical stiffness of the particle. We have explored whether a quantitative linkage exists in MVM particles between their DNA-mediated stiffening and impairment of a heat-induced, virus-inactivating structural change. A series of structurally modified virus particles with disrupted capsid-DNA interactions and/or distorted capsid cavities close to the DNA-binding sites were engineered and characterized, both in classic kinetics assays and by single-molecule mechanical analysis using atomic force microscopy. The rate constant of the virus inactivation reaction was found to decrease exponentially with the increase in elastic constant (stiffness) of the regions closer to DNA-binding sites. The application of transition state theory suggests that the height of the free energy barrier of the virus-inactivating structural transition increases linearly with local mechanical stiffness. From a virological perspective, the results indicate that infectious MVM particles may have acquired the biological advantage of increased survival under thermal stress by evolving architectural elements that rigidify the particle and impair non-productive structural changes. From a nanotechnological perspective, this study provides proof of principle that determination of mechanical stiffness and its manipulation by protein engineering may be applied for quantitatively probing and tuning the conformational dynamics of virus-based and other protein-based nanoassemblies.Viruses are increasingly being studied from the perspective of fundamental physics at the nanoscale as biologically evolved nanodevices with many technological applications. In viral particles of the minute virus of mice (MVM), folded segments of the single-stranded DNA genome are bound to the capsid inner wall and act as molecular buttresses that increase locally the mechanical stiffness of the particle. We have explored whether a quantitative linkage exists in MVM particles between their DNA-mediated stiffening and impairment of a heat-induced, virus-inactivating structural change. A series of structurally modified virus particles with disrupted capsid-DNA interactions and/or distorted capsid cavities close to the DNA-binding sites were engineered and characterized, both in classic kinetics assays and by single-molecule mechanical analysis using atomic force microscopy. The rate constant of the virus inactivation reaction was found to decrease exponentially with the increase in elastic constant (stiffness) of the regions closer to DNA-binding sites. The application of transition state theory suggests that the height of the free energy barrier of the virus-inactivating structural transition increases linearly with local mechanical stiffness. From a virological perspective, the results indicate that infectious MVM particles may have acquired the biological advantage of increased survival under thermal stress by evolving architectural elements that rigidify the particle and impair non-productive structural changes. From a nanotechnological perspective, this study provides proof of principle that determination of mechanical stiffness and its manipulation by protein engineering may be applied for quantitatively probing and tuning the conformational dynamics of virus-based and other protein-based nanoassemblies. Electronic supplementary information (ESI) available. See DOI: 10.1039/c4nr07046a

Construction of Engineering Education Program based on the Alumni's Evaluation of the Educational Outcome

NASA Astrophysics Data System (ADS)

Tsukamoto, Takehiko; Nishizawa, Hitoshi

The Department of Electrical and Electronic Engineering in Toyota National College of Technology has put great emphasis on fundamental subjects, such as “electrical and electronic circuit" and “electromagnetism" more than 40 years. On the other hand, several issues of our college were clarified by the alumni's evaluation of the educational outcome in 2002. The most serious issue was low achievement of English and Social education. The alumni of all generation are dissatisfied with their low skill in English communication. As a part of the educational reforms, our department has constructed a new engineering education program focusing on fundamental ability. We introduced many problem-based-learning experiments and the compulsory subjects such as “English communication for electrical engineers" and “Engineering Ethics" into this program. Great educative results are obtained by these improvements. As a typical example, the scores of all 2nd grade students of advanced engineering course in TOEIC tests became 450 points or more. Our program has been authorized by JABEE since 2004.

Remediation Optimization: Definition, Scope and Approach

EPA Pesticide Factsheets

This document provides a general definition, scope and approach for conducting optimization reviews within the Superfund Program and includes the fundamental principles and themes common to optimization.