13C-based metabolic flux analysis: fundamentals and practice.

PubMed

Yang, Tae Hoon

2013-01-01

Isotope-based metabolic flux analysis is one of the emerging technologies applied to system level metabolic phenotype characterization in metabolic engineering. Among the developed approaches, (13)C-based metabolic flux analysis has been established as a standard tool and has been widely applied to quantitative pathway characterization of diverse biological systems. To implement (13)C-based metabolic flux analysis in practice, comprehending the underlying mathematical and computational modeling fundamentals is of importance along with carefully conducted experiments and analytical measurements. Such knowledge is also crucial when designing (13)C-labeling experiments and properly acquiring key data sets essential for in vivo flux analysis implementation. In this regard, the modeling fundamentals of (13)C-labeling systems and analytical data processing are the main topics we will deal with in this chapter. Along with this, the relevant numerical optimization techniques are addressed to help implementation of the entire computational procedures aiming at (13)C-based metabolic flux analysis in vivo.

Op. Cit.

ERIC Educational Resources Information Center

Zemsky, Robert, Ed.

2001-01-01

The fundamental concern of the roundtable on which this essay is based was the world of scholarship's ability to sustain and develop a system of scholarly communication that makes individual contributions to the knowledge base broadly accessible for judgment within and among the academic disciplines. The focus was on the disciplines that have…

Fundamental Vocabulary Selection Based on Word Familiarity

NASA Astrophysics Data System (ADS)

Sato, Hiroshi; Kasahara, Kaname; Kanasugi, Tomoko; Amano, Shigeaki

This paper proposes a new method for selecting fundamental vocabulary. We are presently constructing the Fundamental Vocabulary Knowledge-base of Japanese that contains integrated information on syntax, semantics and pragmatics, for the purposes of advanced natural language processing. This database mainly consists of a lexicon and a treebank: Lexeed (a Japanese Semantic Lexicon) and the Hinoki Treebank. Fundamental vocabulary selection is the first step in the construction of Lexeed. The vocabulary should include sufficient words to describe general concepts for self-expandability, and should not be prohibitively large to construct and maintain. There are two conventional methods for selecting fundamental vocabulary. The first is intuition-based selection by experts. This is the traditional method for making dictionaries. A weak point of this method is that the selection strongly depends on personal intuition. The second is corpus-based selection. This method is superior in objectivity to intuition-based selection, however, it is difficult to compile a sufficiently balanced corpora. We propose a psychologically-motivated selection method that adopts word familiarity as the selection criterion. Word familiarity is a rating that represents the familiarity of a word as a real number ranging from 1 (least familiar) to 7 (most familiar). We determined the word familiarity ratings statistically based on psychological experiments over 32 subjects. We selected about 30,000 words as the fundamental vocabulary, based on a minimum word familiarity threshold of 5. We also evaluated the vocabulary by comparing its word coverage with conventional intuition-based and corpus-based selection over dictionary definition sentences and novels, and demonstrated the superior coverage of our lexicon. Based on this, we conclude that the proposed method is superior to conventional methods for fundamental vocabulary selection.

An Antipodean Evaluation of Problem-Based Learning by Clinical Educators.

ERIC Educational Resources Information Center

Williams, Allison F.

1999-01-01

The use of problem-based learning in an Australian nursing education program was evaluated through interviews with 14 clinical teachers. They saw improvement in students' self-direction and holistic views of patients, but felt students lacked psychomotor skills and fundamental knowledge of anatomy and physiology. (SK)

22 CFR 126.5 - Canadian exemptions.

Code of Federal Regulations, 2010 CFR

2010-04-01

... assistance from a U.S. exporter. This transaction is based strictly on a “hand-off” approach because the... the U.S. exporter. This transaction is based strictly on a “hands-off” approach since the foreign... systemic study directed toward greater knowledge or understanding of the fundamental aspects of phenomena...

“Shrink Wrapping” Lectures: Teaching Cell and Molecular Biology within the Context of Human Pathologies

PubMed Central

2005-01-01

Students are most motivated and learn best when they are immersed in an environment that causes them to realize why they should learn. Perhaps nowhere is this truer than when teaching the biological sciences to engineers. Transitioning from a traditionally mathematics-based to a traditionally knowledge-based pedagogical style can challenge student learning and engagement. To address this, human pathologies were used as a problem-based context for teaching knowledge-based cell biological mechanisms. Lectures were divided into four modules. First, a disease was presented from clinical, economic, and etiological standpoints. Second, fundamental concepts of cell and molecular biology were taught that were directly relevant to that disease. Finally, we discussed the cellular and molecular basis of the disease based on these fundamental concepts, together with current clinical approaches to the disease. The basic science is thus presented within a “shrink wrap” of disease application. Evaluation of this contextual technique suggests that it is very useful in improving undergraduate student focus and motivation, and offers many advantages to the instructor as well. PMID:15917872

Fundamentals of computer graphics for artists and designers

DOE Office of Scientific and Technical Information (OSTI.GOV)

Riley, B.A.

1986-01-01

This tutorial provides introductory information about computer graphics slanted towards novice users from artist/designer backgrounds. The goal is to describe the applications and terminology sufficiently to provide a base of knowledge for discussions with vendors.

Cyberscience and the Knowledge-Based Economy. Open Access and Trade Publishing: From Contradiction to Compatibility with Non-Exclusive Copyright Licensing

ERIC Educational Resources Information Center

Armbruster, Chris

2008-01-01

Open source, open content and open access are set to fundamentally alter the conditions of knowledge production and distribution. Open source, open content and open access are also the most tangible result of the shift towards e-science and digital networking. Yet, widespread misperceptions exist about the impact of this shift on knowledge…

Evidence-Based Practice in Mental Health Care to Ethnic Minority Communities: Has Its Practice Fallen Short of Its Evidence?

ERIC Educational Resources Information Center

Aisenberg, Eugene

2008-01-01

Evidence-based practice (EBP) has contributed substantially to the advancement of knowledge in the treatment and prevention of adult mental health disorders. A fundamental assumption, based on documented evidence of effectiveness with certain populations, is that EBP is equally effective and applicable to all populations. However, small sample…

Integration of LCoS-SLM and LabVIEW based software to simulate fundamental optics, wave optics, and Fourier optics

NASA Astrophysics Data System (ADS)

Lyu, Bo-Han; Wang, Chen; Tsai, Chun-Wei

2017-08-01

Jasper Display Corp. (JDC) offer high reflectivity, high resolution Liquid Crystal on Silicon - Spatial Light Modulator (LCoS-SLM) which include an associated controller ASIC and LabVIEW based modulation software. Based on this LCoS-SLM, also called Education Kit (EDK), we provide a training platform which includes a series of optical theory and experiments to university students. This EDK not only provides a LabVIEW based operation software to produce Computer Generated Holograms (CGH) to generate some basic diffraction image or holographic image, but also provides simulation software to verity the experiment results simultaneously. However, we believe that a robust LCoSSLM, operation software, simulation software, training system, and training course can help students to study the fundamental optics, wave optics, and Fourier optics more easily. Based on these fundamental knowledges, they could develop their unique skills and create their new innovations on the optoelectronic application in the future.

Theatrical Makeup Enhances the Drama.

ERIC Educational Resources Information Center

Aiex, Patrick K.

With a little practice, even an amateur or classroom technician can learn the fundamentals of simple theatrical makeup. The principles of stage makeup and its application begin with a knowledge of the materials and the tools used to apply them. Base, liner, rouge, eye shadow, lipstick, and finishing powder are the basic materials. Base comes in…

Virtual Tissues and Developmental Systems Biology (book chapter)

EPA Science Inventory

Virtual tissue (VT) models provide an in silico environment to simulate cross-scale properties in specific tissues or organs based on knowledge of the underlying biological networks. These integrative models capture the fundamental interactions in a biological system and enable ...

Temporal Changes in Education Gradients of ‘Preventable’ Mortality: A Test of Fundamental Cause Theory

PubMed Central

Masters, Ryan K.; Link, Bruce G.; Phelan, Jo C.

2015-01-01

Fundamental cause theory explains persisting associations between socioeconomic status and mortality in terms of personal resources such as knowledge, money, power, prestige, and social connections, as well as disparate social contexts related to these resources. We review evidence concerning fundamental cause theory and test three central claims using the National Health Interview Survey Linked Mortality Files 1986-2004. We then examine cohort-based variation in the associations between a fundamental social cause of disease, educational attainment, and mortality rates from heart disease, other “preventable” causes of death, and less preventable causes of death. We further explore race/ethnic and gender variation in these associations. Overall, findings are consistent with nearly all features of fundamental cause theory. Results show, first, larger education gradients in mortality risk for causes of death that are under greater human control than for less preventable causes of death, and, second, that these gradients grew more rapidly across successive cohorts than gradients for less preventable causes. Results also show that relative sizes and cohort-based changes in the education gradients vary substantially by race/ethnicity and gender. PMID:25556675

Revisiting an Old Methodology for Teaching Counting, Computation, and Place Value: The Effectiveness of the Finger Calculation Method for At-Risk Children

ERIC Educational Resources Information Center

Calder Stegemann, Kim; Grünke, Matthias

2014-01-01

Number sense is critical to the development of higher order mathematic abilities. However, some children have difficulty acquiring these fundamental skills and the knowledge base of effective interventions/remediation is relatively limited. Based on emerging neuro-scientific research which has identified the association between finger…

Knowledge Management in Public Health: Examining the Role of a Web-Based Reporting System for Tobacco Control

ERIC Educational Resources Information Center

Gottlieb, Amy Sue

2009-01-01

The importance and use of data and information to make sound programmatic decisions are receiving increased attention as state and federal funding for public health programs grows tighter and as demands for accountability continue. This dissertation provides insight into fundamental questions regarding the utilization of a Web-based reporting…

Fundamentals and Catalytic Applications of CeO2-Based Materials.

PubMed

Montini, Tiziano; Melchionna, Michele; Monai, Matteo; Fornasiero, Paolo

2016-05-25

Cerium dioxide (CeO2, ceria) is becoming an ubiquitous constituent in catalytic systems for a variety of applications. 2016 sees the 40(th) anniversary since ceria was first employed by Ford Motor Company as an oxygen storage component in car converters, to become in the years since its inception an irreplaceable component in three-way catalysts (TWCs). Apart from this well-established use, ceria is looming as a catalyst component for a wide range of catalytic applications. For some of these, such as fuel cells, CeO2-based materials have almost reached the market stage, while for some other catalytic reactions, such as reforming processes, photocatalysis, water-gas shift reaction, thermochemical water splitting, and organic reactions, ceria is emerging as a unique material, holding great promise for future market breakthroughs. While much knowledge about the fundamental characteristics of CeO2-based materials has already been acquired, new characterization techniques and powerful theoretical methods are deepening our understanding of these materials, helping us to predict their behavior and application potential. This review has a wide view on all those aspects related to ceria which promise to produce an important impact on our life, encompassing fundamental knowledge of CeO2 and its properties, characterization toolbox, emerging features, theoretical studies, and all the catalytic applications, organized by their degree of establishment on the market.

Knowledge-based and model-based hybrid methodology for comprehensive waste minimization in electroplating plants

NASA Astrophysics Data System (ADS)

Luo, Keqin

1999-11-01

The electroplating industry of over 10,000 planting plants nationwide is one of the major waste generators in the industry. Large quantities of wastewater, spent solvents, spent process solutions, and sludge are the major wastes generated daily in plants, which costs the industry tremendously for waste treatment and disposal and hinders the further development of the industry. It becomes, therefore, an urgent need for the industry to identify technically most effective and economically most attractive methodologies and technologies to minimize the waste, while the production competitiveness can be still maintained. This dissertation aims at developing a novel WM methodology using artificial intelligence, fuzzy logic, and fundamental knowledge in chemical engineering, and an intelligent decision support tool. The WM methodology consists of two parts: the heuristic knowledge-based qualitative WM decision analysis and support methodology and fundamental knowledge-based quantitative process analysis methodology for waste reduction. In the former, a large number of WM strategies are represented as fuzzy rules. This becomes the main part of the knowledge base in the decision support tool, WMEP-Advisor. In the latter, various first-principles-based process dynamic models are developed. These models can characterize all three major types of operations in an electroplating plant, i.e., cleaning, rinsing, and plating. This development allows us to perform a thorough process analysis on bath efficiency, chemical consumption, wastewater generation, sludge generation, etc. Additional models are developed for quantifying drag-out and evaporation that are critical for waste reduction. The models are validated through numerous industrial experiments in a typical plating line of an industrial partner. The unique contribution of this research is that it is the first time for the electroplating industry to (i) use systematically available WM strategies, (ii) know quantitatively and accurately what is going on in each tank, and (iii) identify all WM opportunities through process improvement. This work has formed a solid foundation for the further development of powerful WM technologies for comprehensive WM in the following decade.

Theories of Modern Management.

ERIC Educational Resources Information Center

Knight, W. Hal

This chapter of "Principles of School Business Management" identifies management theories that provide a fundamental conceptual knowledge base that school business officials can use to understand the school organizational setting and its influences on the day-to-day operation of the educational process. Particular attention is paid to…

Vocabulary Levels and Size of Malaysian Undergraduates

ERIC Educational Resources Information Center

Harji, Madhubala Bava; Balakrishnan, Kavitha; Bhar, Sareen Kaur; Letchumanan, Krishnaveni

2015-01-01

Vocabulary is a fundamental requirement of language acquisition, and its competence enables independent reading and effective language acquisition. Effective language use requires adequate level of vocabulary knowledge; therefore, efforts must be made to identify students' vocabulary base for greater efficiency and competency in the language.…

PROBABILISTIC PROGRAMMING FOR ADVANCED MACHINE LEARNING (PPAML) DISCRIMINATIVE LEARNING FOR GENERATIVE TASKS (DILIGENT)

DTIC Science & Technology

2017-11-29

Structural connections of the frames (fragments) in the knowledge. We call the fundamental elements of the knowledge a limited number of elements...the result of contracted fundamental research deemed exempt from public affairs security and policy review in accordance with SAF/AQR memorandum dated...AVAILABILITY STATEMENT Approved for Public Release; Distribution Unlimited. This report is the result of contracted fundamental research deemed exempt from

European research efforts in medical knowledge-based systems.

PubMed

Stefanelli, M

1993-04-01

This article describes the major projects going on in Europe in the field of Artificial Intelligence in Medicine. The important role of the Commission of the European Communities in providing the needed resources is stressed throughout the paper. Particular attention is given to the methodological and technological issues addressed by the European research teams, since the results which these teams accomplish are fundamental for a more extensive diffusion of knowledge-based systems in real medical settings. The variety of medical problems tackled shows that there is no field of medicine where the potential of advanced informatics technologies has not yet been assessed.

Information Technology for the Twenty-First Century: A Bold Investment in America's Future

NASA Astrophysics Data System (ADS)

1999-06-01

With this Information Technology for the Twenty First Century (IT2) initiative, the Federal Government is making an important re-commitment to fundamental research in information technology. The IT2 initiative proposes 366 million in increased investments in computing, information, and communications research and development (R&D) to help expand the knowledge base in fundamental information science, advance the Nations capabilities in cutting edge research, and train the next generation of researchers who will sustain the Information Revolution well into the 21st Century.

A comparison of two differential methods for nutrition education in elementary school: lecture-and experience-based learning program.

PubMed

Jung, Lan-Hee; Choi, Jeong-Hwa; Bang, Hyun-Mi; Shin, Jun-Ho; Heo, Young-Ran

2015-02-01

This research was conducted to compare lecture-and experience-based methods of nutritional education as well as provide fundamental data for developing an effective nutritional education program in elementary schools. A total of 110 students in three elementary schools in Jeollanam-do were recruited and randomly distributed in lecture-and experience-based groups. The effects of education on students' dietary knowledge, dietary behaviors, and dietary habits were analyzed using a pre/post-test. Lecture-and experience-based methods did not significantly alter total scores for dietary knowledge in any group, although lecture-based method led to improvement for some detailed questions. In the experience-based group, subjects showed significant alteration of dietary behaviors, whereas lecture-based method showed alteration of dietary habits. These outcomes suggest that lecture-and experience-based methods led to differential improvement of students' dietary habits, behaviors, and knowledge. To obtain better nutritional education results, both lectures and experiential activities need to be considered.

Using Concept Mapping to Uncover Students' Knowledge Structures of Chemical Bonding Concepts

ERIC Educational Resources Information Center

Burrows, Nikita L.; Mooring, Suazette Reid

2015-01-01

General chemistry is the first undergraduate course in which students further develop their understanding of fundamental chemical concepts. Many of these fundamental topics highlight the numerous conceptual interconnections present in chemistry. However, many students possess incoherent knowledge structures regarding these topics. Therefore,…

Assessment Literacy in Primary Physical Education

ERIC Educational Resources Information Center

DinanThompson, Maree; Penney, Dawn

2015-01-01

Internationally, assessment is acknowledged as a critical aspect of pedagogical practice and accountability systems, and as having a fundamental bearing upon what knowledge and ways of articulating knowledge come to be valued in schools. Teachers' assessment literacy is arguably fundamental to their ability to successfully engage with multiple…

Trends in education gradients of 'preventable' mortality: a test of fundamental cause theory.

PubMed

Masters, Ryan K; Link, Bruce G; Phelan, Jo C

2015-02-01

Fundamental cause theory explains persisting associations between socioeconomic status and mortality in terms of personal resources such as knowledge, money, power, prestige, and social connections, as well as disparate social contexts related to these resources. We review evidence concerning fundamental cause theory and test three central claims using the National Health Interview Survey Linked Mortality Files 1986-2004. We then examine cohort-based variation in the associations between a fundamental social cause of disease, educational attainment, and mortality rates from heart disease, other "preventable" causes of death, and less preventable causes of death. We further explore race/ethnic and gender variation in these associations. Overall, findings are consistent with nearly all features of fundamental cause theory. Results show, first, larger education gradients in mortality risk for causes of death that are under greater human control than for less preventable causes of death, and, second, that these gradients grew more rapidly across successive cohorts than gradients for less preventable causes. Results also show that relative sizes and cohort-based changes in the education gradients vary substantially by race/ethnicity and gender. Copyright © 2014 Elsevier Ltd. All rights reserved.

Knowledge bases, clinical decision support systems, and rapid learning in oncology.

PubMed

Yu, Peter Paul

2015-03-01

One of the most important benefits of health information technology is to assist the cognitive process of the human mind in the face of vast amounts of health data, limited time for decision making, and the complexity of the patient with cancer. Clinical decision support tools are frequently cited as a technologic solution to this problem, but to date useful clinical decision support systems (CDSS) have been limited in utility and implementation. This article describes three unique sources of health data that underlie fundamentally different types of knowledge bases which feed into CDSS. CDSS themselves comprise a variety of models which are discussed. The relationship of knowledge bases and CDSS to rapid learning health systems design is critical as CDSS are essential drivers of rapid learning in clinical care. Copyright © 2015 by American Society of Clinical Oncology.

Reviewing the Connection between Paradigms and Theories to Understand Adolescent Drug Use

ERIC Educational Resources Information Center

Clark, Trenette T.

2010-01-01

Approaches to studying social phenomenon are fundamentally based upon personal beliefs about the nature of knowledge, reality, and order. Scholars, researchers, and practitioners can benefit from utilizing a coherent method that organizes the wide array of perspectives that exist and the theories, practice, prevention interventions, and policies…

Using Questioning to Stimulate Mathematical Thinking

ERIC Educational Resources Information Center

Way, Jenni

2008-01-01

Good questioning techniques have long been regarded as a fundamental tool of effective teachers and research has found that "differences in students' thinking and reasoning could be attributed to the type of questions that teachers asked" (Wood, 2002). Past research shows that 93% of teacher questions were "lower order" knowledge-based questions…

Relating nanoindentation to macroindentation of wood

Treesearch

Robert J. Moon; Joseph E. Jakes; Jim F. Beecher; Charles R. Frihart; Donald S. Stone

2009-01-01

Wood has several levels of hierarchical structure, spanning from the configuration of growth-rings down to the configuration of the base polymers (cellulose, hemicellulose, and lignin). The bulk properties of wood result from the culmination of interactions over all length scales. Gaps presently exist in the fundamental knowledge relating the contribution of wood...

Genotyping-by-sequencing reveals the origin of the Tunisian relatives of cultivated carrot

USDA-ARS?s Scientific Manuscript database

Knowledge of the morphological diversity of a germplasm collection is fundamental for genebank managers and plant breeders. The main objective of this work was to characterize 33 landraces of carrot from 13 different regions of Tunisia, based on 34 agro-morphological characters related to leaves and...

Fuzzy logic knowledge bases in integrated landscape assessment: examples and possibilities.

Treesearch

Keith M. Reynolds

2001-01-01

The literature on ecosystem management has articulated the need for integration across disciplines and spatial scales, but convincing demonstrations of integrated analysis to support ecosystem management are lacking. This paper focuses on integrated ecological assessment because ecosystem management fundamentally is concerned with integrated management, which...

Considerations for Pursuing a Doctoral Degree in PETE

ERIC Educational Resources Information Center

Jones, Emily; Lux, Karen

2012-01-01

The path to becoming a physical education teacher traditionally involves a university-based teacher education program. It is here that aspiring teachers learn basic skills, gain the fundamental knowledge, and experience teaching for the first time. None of this is possible without quality physical education teacher education (PETE) faculty--those…

Assessing Teaching Skills with a Mobile Simulation

ERIC Educational Resources Information Center

Gibson, David

2013-01-01

Because mobile technologies are overtaking personal computers as the primary tools of Internet access, and cloud-based resources are fundamentally transforming the world's knowledge, new forms of teaching and assessment are required to foster 21st century literacies, including those needed by K-12 teachers. A key feature of mobile technology…

The Complex Relations between the Academy and Industry: Views from the Literature.

ERIC Educational Resources Information Center

Anderson, Melissa S.

2001-01-01

This report on university-industry relations and their effects on higher education is based on three recently published books: Slaughter and Leslie's "Academic Capitalism"; Etzkowitz, Webster, and Healey's "Capitalizing Knowledge"; and Tudiver's "Universities for Sale." It reviews the implications of fundamental changes in the nature of…

Managing the Research Function of the University: Pressures and Dilemmas

ERIC Educational Resources Information Center

Mintrom, Michael

2008-01-01

How should universities manage their research function? Today, research-based knowledge is viewed widely as fundamental to economic advancement. As a result, universities everywhere are facing pressure to rethink their research activities. A general model of the research process is presented here. Linkages are drawn between that process, other…

Development and Implementation of an Innovative Burn Nursing Handbook for Quality Improvement

PubMed Central

Olszewski, Anna; Yanes, Amber; Stafford, Jessica; Greenhalgh, David G.; Palmieri, Tina L.; Sen, Soman; Tran, Nam

2015-01-01

Objective Evidence-based burn nursing literature is extremely limited and often non-existent. As a result, there is a lack of standardization in burn nursing care. Our objective is to evaluate burn nursing knowledge at an academic medical center and implement innovative educational tools to enhance staff competency and improve the quality of care. Methods A collaboration of practicing clinical nurses developed a 24-question knowledge assessment survey (“pre-survey”) to evaluate fundamental burn nursing knowledge (fluid management, burn pathophysiology, burn-related procedures, wound care, infection control). Pre-education knowledge surveys were administered to 59 burn nurses electronically. A writing team of new and experienced nurses was established and developed a 51-page handbook focusing on areas of need identified in the survey. This book was disseminated to staff as required reading. Post-educational surveys were sent to the same nurses who completed the initial survey. Results Forty-six nurses (46/59, 78.0%) completed the survey with a mean (SD) of 55.9 (11.0)% of questions being answered correctly. Post-surveys sent to the same 46 nurses who completed the pre-survey had a response rate of 78.3% (36/46). We observed a significant increase in correctly answered questions (mean [SD]: 69.6 (8.7)%, P<0.001) in the post-survey intervention. Conclusion The handbook improved education and significantly improved overall fundamental burn knowledge of practicing nursing staff. Use of electronic surveys to drive development of targeted educational interventions provides evidence-based tools for establishing burn nursing standards and developing quality improvement metrics. PMID:26284646

Antecedents of Intrinsic Motivation, Metacognition and Their Effects on Students' Academic Performance in Fundamental Knowledge for Matriculation Courses

ERIC Educational Resources Information Center

Ibrahim, Mikail; Baharun, Hazleena; Harun, Haliza; Othman, Normah

2017-01-01

Purpose: This study examined the interrelationships between a set of antecedent academic intrinsic motivations and metacognitive strategy such as goal orientation, perceived value and religiosity in Fundamental Knowledge for Matriculation courses (FKM). It also investigated the relationship between intrinsic motivation and metacognitive strategy…

Reconciliation and the Academy: Experience at a Small Institution in Northern Manitoba

ERIC Educational Resources Information Center

Smith, Dan

2017-01-01

This article accepts a definition of reconciliation that includes a need for fundamental change in society. The article argues that "knowledge" is critical to the business of the academic enterprise and that the relationship the academy has with knowledge is fundamental; for the academy to truly reconcile, then, changing that…

[A Study of the Evidence-Based Nursing Practice Competence of Nurses and Its Clinical Applications].

PubMed

Hsu, Li-Ling; Hsieh, Suh-Ing; Huang, Ya-Hsuan

2015-10-01

Nurses must develop competence in evidence-based nursing in order to provide the best practice medical care to patients. Evidence-based nursing uses issue identification, data mining, and information consolidation from the related medical literature to help nurses find the best evidence. Therefore, for medical institutions to provide quality clinical care, it is necessary for nurses to develop competence in evidence-based nursing. This study aims to explore the effect of a fundamental evidence-based nursing course, as a form of educational intervention, on the development of evidence-based nursing knowledge, self-efficacy in evidence-based practice activities, and outcome expectations of evidence-based practice in nurse participants. Further the competence of these nurses in overcoming obstacles in evidence-based nursing practice. This quasi-experimental study used a pre-post test design with a single group of participants. A convenience sample of 34 nurses from a municipal hospital in northern Taiwan received 8 hours of a fundamental evidence-based nursing course over a two-week period. Participants were asked to complete four questionnaires before and after the intervention. The questionnaires measured the participants' basic demographics, experience in mining the medical literature, evidence-based nursing knowledge, self-efficacy in evidence-based practice activities, outcome expectations of evidence-based practice, competence in overcoming obstacles in evidence-based nursing practice, and learning satisfaction. Collected data was analyzed using paired t, Wilcoxon Signed Rank, and McNemar tests to measure the differences among participants' evidence-based nursing knowledge and practice activities before and after the workshop. The nurses demonstrated significantly higher scores from pre-test to post-test in evidence-based nursing knowledge II, self-efficacy in evidence-based nursing practice activities, and outcome expectations of evidence-based practice. Although the differences did not reach statistical significance, the post-test scores were significantly lower than pre-test scores in terms of the measurement of the nurses' obstacles in evidence-based nursing practice, which indicates significant improvements from pre-test to post-test in terms of the competence of participants in overcoming obstacles in evidence-based nursing practice. The intervention was found to be effective in improving the evidence-based nursing knowledge, self-efficacy in evidence-based nursing practice activities, and outcome expectations of evidence-based practice of participants and effective in reducing their obstacles in evidence-based nursing practice. Medical institutions should provide evidence-based nursing courses on a regular basis as a part of in-service education for nurses in order to help nurses develop the evidence-based nursing knowledge and practical competence required to provide quality clinical care.

Balancing regulatory control, scientific knowledge, and public understanding.

PubMed

Kingsbury, D T

1988-01-01

In summary, I would like to emphasize the continued need for broad and vigorous basic research, with a balance between the fundamental work that may eventually lead to commercial products and the fundamental work that is necessary for an understanding of the interaction of many types of organisms within the environment. I would like also to reiterate the need for balance in the regulatory approach so that we do not repress innovation in research and development. Over-regulation has many side effects. In addition to repressing innovation and not taking advantage of our research base, over-regulation leads to reluctance by the capital markets to invest in the future of our new industries, thereby halting their development at an early stage. At the same time, under-regulation leads to lack of confidence by the public and paralysis of the industry based on public outcry and legal proceedings. It is my personal belief that the combination of a sound approach to regulatory practice, based on current scientific knowledge, combined with appropriate communication with the public regarding the new products, will lead to an exciting future for all sectors of industry that use the new biotechnology.

Rainfall: State of the Science

NASA Astrophysics Data System (ADS)

Testik, Firat Y.; Gebremichael, Mekonnen

Rainfall: State of the Science offers the most up-to-date knowledge on the fundamental and practical aspects of rainfall. Each chapter, self-contained and written by prominent scientists in their respective fields, provides three forms of information: fundamental principles, detailed overview of current knowledge and description of existing methods, and emerging techniques and future research directions. The book discusses • Rainfall microphysics: raindrop morphodynamics, interactions, size distribution, and evolution • Rainfall measurement and estimation: ground-based direct measurement (disdrometer and rain gauge), weather radar rainfall estimation, polarimetric radar rainfall estimation, and satellite rainfall estimation • Statistical analyses: intensity-duration-frequency curves, frequency analysis of extreme events, spatial analyses, simulation and disaggregation, ensemble approach for radar rainfall uncertainty, and uncertainty analysis of satellite rainfall products The book is tailored to be an indispensable reference for researchers, practitioners, and graduate students who study any aspect of rainfall or utilize rainfall information in various science and engineering disciplines.

The Acquisition and Transfer of Knowledge of Electrokinetic-Hydrodynamics (EKHD) Fundamentals: an Introductory Graduate-Level Course

ERIC Educational Resources Information Center

Pascal, Jennifer; Tíjaro-Rojas, Rocío; Oyanader, Mario A.; Arce, Pedro E.

2017-01-01

Relevant engineering applications, such as bioseparation of proteins and DNA, soil-cleaning, motion of colloidal particles in different media, electrical field-based cancer treatments, and the cleaning of surfaces and coating flows, belongs to the family of "Applied Field Sensitive Process Technologies" requiring an external field to…

The Theory of Multiple Intelligences: A Case of Missing Cognitive Matter.

ERIC Educational Resources Information Center

Allix, Nicholas M.

2000-01-01

Argues that although Gardner's conception of human cognition, characterized by a set of multiple and distinct cognitive capabilities, is an advance over the narrow conception of IQ, it runs into fundamental difficulties of a methodological kind and is based on a discredited empiricist theory of knowledge which work with artificial neural networks…

Implementation of Gender Studies Results into Teacher Training in Germany: Challenges and Perspectives

ERIC Educational Resources Information Center

Gryvkova, Olena

2017-01-01

Introduction of gender-specific approaches in education is a new step in the development of pedagogical anthropology. Pedagogy as a fundamental complex discipline, which is based on the latest achievements of knowledge about a human, cannot stand aside the transformational modifications of the societies and cannot help responding to their…

An Examination of the Role of Emotions in Antiracist Pedagogy: Implications, Scholarship, and Practices

ERIC Educational Resources Information Center

Grosland, Tanetha J.

2013-01-01

Tanetha Grosland's goal is to inform and extend the current knowledge base concerning the intersection of antiracist pedagogy and emotions, and its implications for reconceptualizing such pedagogy. Therefore, she begins by addressing some fundamental theoretical claims about antiracist education. Then utilizing two sources to contextualize…

Towards a Psychology of Media Education

ERIC Educational Resources Information Center

Lehtonen, Miika; Miloseva, Lence; Page, Tom; Thorsteinsson, Gisli

2008-01-01

This study will introduce some of the fundamentals and rationale for the Psychology of Media Education based on Developmental Psychology. It is an important area of study of a modern teacher profession and teacher education and a new field of multi-, inter- and trans-disciplinary knowledge and research. We argue that without a doubt the different…

A Multidisciplinary Guided Practical on Type I Diabetes Engaging Students in Inquiry-Based Learning

ERIC Educational Resources Information Center

Mingueneau, M.; Chaix, A.; Scotti, N.; Chaix, J.; Reynders, A.; Hammond, C.; Thimonier, J.

2015-01-01

In the present article, we describe a 3-day experimental workshop on type I diabetes aimed at helping high school students to understand how fundamental research on glycemia regulation contributes to the development of scientific knowledge and therapeutic strategies. The workshop engaged students in open-ended investigations and guided…

Convergence of Information and Communication Technology (ICT) Tools in Project Based Learning (PBL)

ERIC Educational Resources Information Center

Thamarasseri, Ismail

2014-01-01

Rapid technological advancement influences the communication and information management as well as knowledge construction. Within the context of new challenges, lifelong learning emerges a fundamental element for the constant development of professionals. So that it dynamically adapts to change and retain a state-of-the-art identity. At present,…

Preschool--An Arena for Children's Learning of Social and Cognitive Knowledge

ERIC Educational Resources Information Center

Williams, Pia; Sheridan, Sonja; Sandberg, Anette

2014-01-01

The aim is to investigate Swedish preschool teachers' accounts of children's learning in relation to the goals in the Swedish preschool curriculum. The research question is: "What do preschool teachers see as fundamental aspects of learning in preschool practice?" The study is based on interactionist perspectives founded in Urie…

An Information Provision Framework for Performance-Based Interactive eLearning Application for Manufacturing

ERIC Educational Resources Information Center

Sanders, Janet H.; Udoka, Silvanus J.

2010-01-01

Fundamental concepts and definitions of electronic learning (eLearning) continue to emerge, and theories of eLearning that have been advanced thus far cover an array of academic perspectives including training and education, learning and knowledge, and technology and applications to specific market segments. Any study of the effectiveness and…

Determining the pH of Mars from the Viking labelled release reabsorption effect

NASA Technical Reports Server (NTRS)

Plumb, Robert C.

1992-01-01

The acid-base properties and redox potentials of solids are two of the more fundamental chemical parameters characterizing a material. Knowledge of these parameters for martian regolith fines would be of considerable value in determining what specific compounds are present and making judgements on what reactions are possible.

Education Reforms in Malaysia.

ERIC Educational Resources Information Center

Yunus, Aida Suraya Muhammad

Malaysia's agenda in the late 1990s involved making the transition from an industrial economy to a knowledge-based economy. Thus, the more traditional purpose of education, that is, to produce an educated person, needs to be reevaluated. If the nation's Vision 2020 is to become a reality, the educational program needs to make a fundamental shift…

A Project-Based Learning Setting to Human-Computer Interaction for Teenagers

ERIC Educational Resources Information Center

Geyer, Cornelia; Geisler, Stefan

2012-01-01

Knowledge of fundamentals of human-computer interaction resp. usability engineering is getting more and more important in technical domains. However this interdisciplinary field of work and corresponding degree programs are not broadly known. Therefore at the Hochschule Ruhr West, University of Applied Sciences, a program was developed to give…

The acquisition and transfer of knowledge of electrokinetic-hydrodynamics (EKHD) fundamentals: an introductory graduate-level course

NASA Astrophysics Data System (ADS)

Pascal, Jennifer; Tíjaro-Rojas, Rocío; Oyanader, Mario A.; Arce, Pedro E.

2017-09-01

Relevant engineering applications, such as bioseparation of proteins and DNA, soil-cleaning, motion of colloidal particles in different media, electrical field-based cancer treatments, and the cleaning of surfaces and coating flows, belongs to the family of 'Applied Field Sensitive Process Technologies' requiring an external field to move solutes in a fluid within a fibrous (or porous) domain. This field incorporates an additional variable that makes the analysis very challenging and can create for the student a number of new problems to solve. A graduate-level course, based on active-learning approaches and High Performance Learning Environments, where transfer of knowledge plays a key role, was designed by the Chemical Engineering Department at Tennessee Technological University. This course, where the fundamentals principles of EKHD were taught to science, engineering and technology students was designed by the Chemical Engineering Department at the Tennessee Technological University, Cookeville, TN. An important number of these students were able to grasp the tools required to advance their research projects that led to numerous technical presentations in professional society meetings and publications in peered-reviewed journals.

Tacit Knowledge of Caring and Embodied Selfhood

PubMed Central

Kontos, Pia C.; Naglie, Gary

2013-01-01

The tacit knowledge paradigm is gaining recognition as an important source of knowledge that informs clinical decision-making. However, it is limited by an exclusive focus on knowledge acquired through clinical practice, and a consequent neglect of the primordial and socio-cultural significance of embodied selfhood, precisely what provides the foundational structure of tacit knowledge of caring and facilitates its manifestation. Drawing on findings from a qualitative study of forty-three dementia care practitioners in Ontario, Canada that utilized research-based drama and focus group methodology, we argue that embodied selfhood is fundamental to tacit knowledge of caring. Results are analyzed drawing upon the theoretical precepts of embodied selfhood that are rooted in Merleau-Ponty’s (1962) reconceptualization of perception and Bourdieu’s (1977, 1990) notion of habitus. We conclude with a call for further exploration of the body as a site of the production of tacit knowledge. PMID:19392935

Tacit knowledge of caring and embodied selfhood.

PubMed

Kontos, Pia C; Naglie, Gary

2009-07-01

The tacit knowledge paradigm is gaining recognition as an important source of knowledge that informs clinical decision-making. It is, however, limited by an exclusive focus on knowledge acquired through clinical practice, and a consequent neglect of the primordial and socio-cultural significance of embodied selfhood, precisely what provides the foundational structure of tacit knowledge of caring and facilitates its manifestation. Drawing on findings from a qualitative study of 43 dementia care practitioners in Ontario, Canada that utilised research-based drama and focus group methodology, we argue that embodied selfhood is fundamental to tacit knowledge of caring. Results are analysed drawing upon the theoretical precepts of embodied selfhood that are rooted in Merleau-Ponty's (1962) reconceptualisation of perception and Bourdieu's (1977, 1990) notion of habitus. We conclude with a call for further exploration of the body as a site of the production of tacit knowledge.

A ligand predication tool based on modeling and reasoning with imprecise probabilistic knowledge.

PubMed

Liu, Weiru; Yue, Anbu; Timson, David J

2010-04-01

Ligand prediction has been driven by a fundamental desire to understand more about how biomolecules recognize their ligands and by the commercial imperative to develop new drugs. Most of the current available software systems are very complex and time-consuming to use. Therefore, developing simple and efficient tools to perform initial screening of interesting compounds is an appealing idea. In this paper, we introduce our tool for very rapid screening for likely ligands (either substrates or inhibitors) based on reasoning with imprecise probabilistic knowledge elicited from past experiments. Probabilistic knowledge is input to the system via a user-friendly interface showing a base compound structure. A prediction of whether a particular compound is a substrate is queried against the acquired probabilistic knowledge base and a probability is returned as an indication of the prediction. This tool will be particularly useful in situations where a number of similar compounds have been screened experimentally, but information is not available for all possible members of that group of compounds. We use two case studies to demonstrate how to use the tool. 2009 Elsevier Ireland Ltd. All rights reserved.

BaTiO3-based piezoelectrics: Fundamentals, current status, and perspectives

NASA Astrophysics Data System (ADS)

Acosta, M.; Novak, N.; Rojas, V.; Patel, S.; Vaish, R.; Koruza, J.; Rossetti, G. A.; Rödel, J.

2017-12-01

We present a critical review that encompasses the fundamentals and state-of-the-art knowledge of barium titanate-based piezoelectrics. First, the essential crystallography, thermodynamic relations, and concepts necessary to understand piezoelectricity and ferroelectricity in barium titanate are discussed. Strategies to optimize piezoelectric properties through microstructure control and chemical modification are also introduced. Thereafter, we systematically review the synthesis, microstructure, and phase diagrams of barium titanate-based piezoelectrics and provide a detailed compilation of their functional and mechanical properties. The most salient materials treated include the (Ba,Ca)(Zr,Ti)O3, (Ba,Ca)(Sn,Ti)O3, and (Ba,Ca)(Hf,Ti)O3 solid solution systems. The technological relevance of barium titanate-based piezoelectrics is also discussed and some potential market indicators are outlined. Finally, perspectives on productive lines of future research and promising areas for the applications of these materials are presented.

The evolution and provision of expert knowledge and its effective utilisation

NASA Astrophysics Data System (ADS)

Sammonds, Peter

2017-04-01

The specific aims of increasing Resilience to Natural Hazards in China programme are (i) to improve hazard forecasting, risk mitigation and preparedness based upon reliable knowledge of the fundamental processes involved and underpinned by basic science and, (ii) to improve the uptake of and responses to scientific advice, by developing risk-based approaches to natural hazards in collaboration with the communities at risk. One of the programme's principal goals is to integrate natural and social science research to increase the benefits for those affected by natural hazards. To that end a co-productive approach to research is expected, involving a framework for sharing knowledge and values between natural and social scientists and consultation with policy makers, civil society and other stakeholders. This paper explore knowledge relationships and reflective learning across disciplines. There is commonly a disjunction between the evolution and provision of expert knowledge and its effective utilisation. Building on experience as Strategic Advisor to the Increasing Resilience to Natural Hazards programme, this paper addresses the research needs to assess how scientific knowledge and risk reduction strategies can be most effectively developed and communicated.

Fundamentals of microfluidics for high school students with no prior knowledge of fluid mechanics.

PubMed

Tandon, Vishal; Peck, Walter

2013-01-01

Three microfluidics-based laboratory exercises were developed and implemented in a high school science classroom setting. The first exercise demonstrated ways in which flows are characterized, including viscosity, turbulence, shear stress, reversibility, compressibility, and hydrodynamic resistance. Students characterized flows in poly(dimethylsiloxane) microfluidic devices in the other two exercises, where they observed the mixing characteristics of laminar flows, and conservation of volumetric flow rate for incompressible flows. In surveys, the students self-reported increased knowledge of microfluidics, and an improved attitude toward science and nanotechnology.

The Tyranny of the Temporal Dimension: Learning about Fundamental Values through the Internet

ERIC Educational Resources Information Center

Alexandersson, Mikael; Runesson, Ulla

2006-01-01

In this article we report on one of four schools involved in a research project aiming to develop knowledge about the way in which teaching knowledge is conveyed with the help of information and communication technology. A particular interest was issues of fundamental values. Two classes in Grade 9 of Swedish compulsory school were studied, by…

Development of Knowledge Profiles for International eHealth eLearning Courses.

PubMed

Herzog, Juliane; Sauermann, Stefan; Mense, Alexander; Forjan, Mathias; Urbauer, Philipp

2015-01-01

Professionals working in the multidisciplinary field of eHealth vary in their educational background. However, knowledge in the areas of medicine, engineering and management is required to fulfil the tasks associated with eHealth sufficiently. Based on the results of an analysis of national and international educational offers a survey gathering user requirements for the development of knowledge profiles in eHealth was conducted (n=75) by professionals and students. During a workshop the first results were presented and discussed together with the network partners and the attendees. The resulting knowledge profiles contain knowledge areas of all three thematic content categories including fundamentals of medical terminology, standards and interoperability and usability as well as basics of all three content categories. The knowledge profiles are currently applied in a master's degree programme at the UAS Technikum Wien and will be developed further.

The Promise of Law-Related Education as Delinquency Prevention. Technical Assistance Bulletin.

ERIC Educational Resources Information Center

Parrini, Michelle, Ed.

According to the Law Related Education Act of 1978, Law-Related Education (LRE) can be defined as "education to equip nonlawyers with knowledge and skills pertaining to the law, the legal process, the legal system, and the fundamental principles and values on which these are based." LRE teaches essential concepts of democracy, including…

Applying Computerized Concept Maps in Guiding Pupils to Reason and Solve Mathematical Problems: The Design Rationale and Effect

ERIC Educational Resources Information Center

Chen, I-Ching; Hu, Shueh-Cheng

2013-01-01

The capability of solving fundamental mathematical problems is essential to elementary school students; however instruction based on ordinary narration usually perplexes students. Concept mapping is well known for its effectiveness on assimilating and organizing knowledge, which is essential to meaningful learning. A variety of concept map-based…

Role of Enhancing Visual Effects Education Delivery to Encounter Career Challenges in Malaysia

ERIC Educational Resources Information Center

Ng, Lynn-Sze

2017-01-01

Problem-based Learning (PBL) is one of the most effective methods of instruction that helps Visual Effects (VFX) students to be more adaptable at encountering career challenges in Malaysia. These challenges are; lack of several important requirements such as, the basic and fundamental knowledge of VFX concepts, the ability to understand real-world…

A Program of Entrepreneurial Education for Economic Development: The Case of Northeast Brazil.

ERIC Educational Resources Information Center

Burke, John Miles

A cross-cultural comparative analysis was made of managerial education programs in the United States and Brazil and, based on the findings, an entrepreneurial education program was designed for underdeveloped Northeast Brazil. Persons were found in this region who could act as entrepreneurs except for a lack of fundamental knowledge and skills;…

Critical Thinking as Integral to Social Work Practice

ERIC Educational Resources Information Center

Gibbons, Jill; Gray, Mel

2004-01-01

The paper examines the role of critical thinking in an experience-based model of social work education. Within this model, the development of a critical approach to our own understanding of, as well as to existing knowledge about, the world is fundamental for students and educators alike. Critical thinking is defined as more than a rational,…

Knowledge Retrieval Solutions.

ERIC Educational Resources Information Center

Khan, Kamran

1998-01-01

Excalibur RetrievalWare offers true knowledge retrieval solutions. Its fundamental technologies, Adaptive Pattern Recognition Processing and Semantic Networks, have capabilities for knowledge discovery and knowledge management of full-text, structured and visual information. The software delivers a combination of accuracy, extensibility,…

Blooms' separation of the final exam of Engineering Mathematics II: Item reliability using Rasch measurement model

NASA Astrophysics Data System (ADS)

Fuaad, Norain Farhana Ahmad; Nopiah, Zulkifli Mohd; Tawil, Norgainy Mohd; Othman, Haliza; Asshaari, Izamarlina; Osman, Mohd Hanif; Ismail, Nur Arzilah

2014-06-01

In engineering studies and researches, Mathematics is one of the main elements which express physical, chemical and engineering laws. Therefore, it is essential for engineering students to have a strong knowledge in the fundamental of mathematics in order to apply the knowledge to real life issues. However, based on the previous results of Mathematics Pre-Test, it shows that the engineering students lack the fundamental knowledge in certain topics in mathematics. Due to this, apart from making improvements in the methods of teaching and learning, studies on the construction of questions (items) should also be emphasized. The purpose of this study is to assist lecturers in the process of item development and to monitor the separation of items based on Blooms' Taxonomy and to measure the reliability of the items itself usingRasch Measurement Model as a tool. By using Rasch Measurement Model, the final exam questions of Engineering Mathematics II (Linear Algebra) for semester 2 sessions 2012/2013 were analysed and the results will provide the details onthe extent to which the content of the item providesuseful information about students' ability. This study reveals that the items used in Engineering Mathematics II (Linear Algebra) final exam are well constructed but the separation of the items raises concern as it is argued that it needs further attention, as there is abig gap between items at several levels of Blooms' cognitive skill.

Doctoring the Knowledge Worker

ERIC Educational Resources Information Center

Tennant, Mark

2004-01-01

In this paper I examine the impact of the new 'knowledge economy' on contemporary doctoral education. I argue that the knowledge economy promotes a view of knowledge and knowledge workers that fundamentally challenges the idea of a university as a community of autonomous scholars transmitting and adding to society's 'stock of knowledge'. The paper…

The Case for Creative Abrasion: Experts Speak Out on Knowledge Management.

ERIC Educational Resources Information Center

Cowley-Durst, Barbara; Christensen, Hal D.; Degler, Duane; Weidner, Douglas; Feldstein, Michael

2001-01-01

Five knowledge management (KM) experts discuss answers to six fundamental issues of KM that address: a definition of knowledge and KM; relationship between business and KM; whether technology has helped the knowledge worker; relationship between learning, performance, knowledge, and community; the promise of knowledge ecology or ecosystem and…

Evolutionary Technologies: Fundamentals and Applications to Information/Communication Systems and Manufacturing/Logistics Systems

NASA Astrophysics Data System (ADS)

Gen, Mitsuo; Kawakami, Hiroshi; Tsujimura, Yasuhiro; Handa, Hisashi; Lin, Lin; Okamoto, Azuma

As efficient utilization of computational resources is increasing, evolutionary technology based on the Genetic Algorithm (GA), Genetic Programming (GP), Evolution Strategy (ES) and other Evolutionary Computations (ECs) is making rapid progress, and its social recognition and the need as applied technology are increasing. This is explained by the facts that EC offers higher robustness for knowledge information processing systems, intelligent production and logistics systems, most advanced production scheduling and other various real-world problems compared to the approaches based on conventional theories, and EC ensures flexible applicability and usefulness for any unknown system environment even in a case where accurate mathematical modeling fails in the formulation. In this paper, we provide a comprehensive survey of the current state-of-the-art in the fundamentals and applications of evolutionary technologies.

Education Program for Ph.D. Course to Cultivate Literacy and Competency

NASA Astrophysics Data System (ADS)

Yokono, Yasuyuki; Mitsuishi, Mamoru

The program aims to cultivate internationally competitive young researchers equipped with Fundamental attainment (mathematics, physics, chemistry and biology, and fundamental social sciences) , Specialized knowledge (mechanical dynamics, mechanics of materials, hydrodynamics, thermodynamics, design engineering, manufacturing engineering and material engineering, and bird‧s-eye view knowledge on technology, society and the environment) , Literacy (Language, information literacy, technological literacy and knowledge of the law) and Competency (Creativity, problem identification and solution, planning and execution, self-management, teamwork, leadership, sense of responsibility and sense of duty) to become future leaders in industry and academia.

Fundamental Fraction Knowledge of Preservice Elementary Teachers: A Cross-National Study in the United States and Taiwan

ERIC Educational Resources Information Center

Luo, Fenqjen; Lo, Jane-Jane; Leu, Yuh-Chyn

2011-01-01

The purpose of this paper is to show the similarities as well as the differences of fundamental fraction knowledge owned by preservice elementary teachers from the United States (N = 89) and Taiwan (N = 85). To this end, we examined and compared their performance on an instrument including 15 multiple-choice test items. The items were categorized…

Software-engineering challenges of building and deploying reusable problem solvers.

PubMed

O'Connor, Martin J; Nyulas, Csongor; Tu, Samson; Buckeridge, David L; Okhmatovskaia, Anna; Musen, Mark A

2009-11-01

Problem solving methods (PSMs) are software components that represent and encode reusable algorithms. They can be combined with representations of domain knowledge to produce intelligent application systems. A goal of research on PSMs is to provide principled methods and tools for composing and reusing algorithms in knowledge-based systems. The ultimate objective is to produce libraries of methods that can be easily adapted for use in these systems. Despite the intuitive appeal of PSMs as conceptual building blocks, in practice, these goals are largely unmet. There are no widely available tools for building applications using PSMs and no public libraries of PSMs available for reuse. This paper analyzes some of the reasons for the lack of widespread adoptions of PSM techniques and illustrate our analysis by describing our experiences developing a complex, high-throughput software system based on PSM principles. We conclude that many fundamental principles in PSM research are useful for building knowledge-based systems. In particular, the task-method decomposition process, which provides a means for structuring knowledge-based tasks, is a powerful abstraction for building systems of analytic methods. However, despite the power of PSMs in the conceptual modeling of knowledge-based systems, software engineering challenges have been seriously underestimated. The complexity of integrating control knowledge modeled by developers using PSMs with the domain knowledge that they model using ontologies creates a barrier to widespread use of PSM-based systems. Nevertheless, the surge of recent interest in ontologies has led to the production of comprehensive domain ontologies and of robust ontology-authoring tools. These developments present new opportunities to leverage the PSM approach.

Software-engineering challenges of building and deploying reusable problem solvers

PubMed Central

O’CONNOR, MARTIN J.; NYULAS, CSONGOR; TU, SAMSON; BUCKERIDGE, DAVID L.; OKHMATOVSKAIA, ANNA; MUSEN, MARK A.

2012-01-01

Problem solving methods (PSMs) are software components that represent and encode reusable algorithms. They can be combined with representations of domain knowledge to produce intelligent application systems. A goal of research on PSMs is to provide principled methods and tools for composing and reusing algorithms in knowledge-based systems. The ultimate objective is to produce libraries of methods that can be easily adapted for use in these systems. Despite the intuitive appeal of PSMs as conceptual building blocks, in practice, these goals are largely unmet. There are no widely available tools for building applications using PSMs and no public libraries of PSMs available for reuse. This paper analyzes some of the reasons for the lack of widespread adoptions of PSM techniques and illustrate our analysis by describing our experiences developing a complex, high-throughput software system based on PSM principles. We conclude that many fundamental principles in PSM research are useful for building knowledge-based systems. In particular, the task–method decomposition process, which provides a means for structuring knowledge-based tasks, is a powerful abstraction for building systems of analytic methods. However, despite the power of PSMs in the conceptual modeling of knowledge-based systems, software engineering challenges have been seriously underestimated. The complexity of integrating control knowledge modeled by developers using PSMs with the domain knowledge that they model using ontologies creates a barrier to widespread use of PSM-based systems. Nevertheless, the surge of recent interest in ontologies has led to the production of comprehensive domain ontologies and of robust ontology-authoring tools. These developments present new opportunities to leverage the PSM approach. PMID:23565031

The Network of Excellence 'Knowledge-based Multicomponent Materials for Durable and Safe Performance'

DOE Office of Scientific and Technical Information (OSTI.GOV)

Moreno, Arnaldo

The Network of Excellence 'Knowledge-based Multicomponent Materials for Durable and Safe Performance' (KMM-NoE) consists of 36 institutional partners from 10 countries representing leading European research institutes and university departments (25), small and medium enterprises, SMEs (5) and large industry (7) in the field of knowledge-based multicomponent materials (KMM), more specifically in intermetallics, metal-ceramic composites, functionally graded materials and thin layers. The main goal of the KMM-NoE (currently funded by the European Commission) is to mobilise and concentrate the fragmented scientific potential in the KMM field to create a durable and efficient organism capable of developing leading-edge research while spreading themore » accumulated knowledge outside the Network and enhancing the technological skills of the related industries. The long-term strategic goal of the KMM-NoE is to establish a self-supporting pan-European institution in the field of knowledge-based multicomponent materials--KMM Virtual Institute (KMM-VIN). It will combine industry oriented research with educational and training activities. The KMM Virtual Institute will be founded on three main pillars: KMM European Competence Centre, KMM Integrated Post-Graduate School, KMM Mobility Programme. The KMM-NoE is coordinated by the Institute of Fundamental Technological Research (IPPT) of the Polish Academy of Sciences, Warsaw, Poland.« less

Combustion of Han-Based Monopropellant Droplets in Reduced Gravity

NASA Technical Reports Server (NTRS)

Shaw, B. D.

1999-01-01

The objective of this research is to study combustion of monopropellant droplets and monopropellant droplet components in reduced-gravity environments so that spherical symmetry is strongly promoted. The experiments will use hydroxylammonium nitrate (HAN, chemical formula NH3OHNO3) based monopropellants. This class of monopropellant is selected for study because of its current relevance and also because it is relatively benign and safe to work with. The experimental studies will allow for accurate determination of fundamental data on deflagration rates, gas-phase temperature profiles, transient gas-phase flame behaviors, the onset of bubbling in droplets at lower pressures, and the low-pressure deflagration limit. The theoretical studies will provide rational models of deflagration mechanisms of HAN-based liquid propellants. Besides advancing fundamental knowledge, the proposed research should aid in applications (e.g., spacecraft thrusters and liquid propellant guns) of this unique class of monopropellants.

Validation of the openEHR archetype library by using OWL reasoning.

PubMed

Menárguez-Tortosa, Marcos; Fernández-Breis, Jesualdo Tomás

2011-01-01

Electronic Health Record architectures based on the dual model architecture use archetypes for representing clinical knowledge. Therefore, ensuring their correctness and consistency is a fundamental research goal. In this work, we explore how an approach based on OWL technologies can be used for such purpose. This method has been applied to the openEHR archetype repository, which is the largest available one nowadays. The results of this validation are also reported in this study.

Contextualizing Learning Chemistry in First-Year Undergraduate Programs: Engaging Industry-Based Videos with Real-Time Quizzing

ERIC Educational Resources Information Center

Urban, Sylvia; Brkljaca, Robert; Cockman, Russell; Rook, Trevor

2017-01-01

First-year undergraduate classes present challenges in teaching as they usually have high student enrolment numbers and students studying across a range of higher education programs that require a fundamental understanding of knowledge that is not perceived in their area of study. This provides a challenge in terms of engaging and maintaining…

Clinical Competencies and the Basic Sciences: An Online Case Tutorial Paradigm for Delivery of Integrated Clinical and Basic Science Content

ERIC Educational Resources Information Center

DiLullo, Camille; Morris, Harry J.; Kriebel, Richard M.

2009-01-01

Understanding the relevance of basic science knowledge in the determination of patient assessment, diagnosis, and treatment is critical to good medical practice. One method often used to direct students in the fundamental process of integrating basic science and clinical information is problem-based learning (PBL). The faculty facilitated small…

Anthropological Diplomacy: Case Studies in the Applications of Anthropology to International Relations. Studies in Third World Societies, Publication Number Twenty-One.

ERIC Educational Resources Information Center

Magnarella, Paul J., Ed.

Six articles in this volume focus on anthropological diplomacy--the study of the theory and practice of peace and conflict resolution among societies, based on knowledge of a society's fundamental cultural premises. The first article, by Ronald Cohen, considers questions pertinent to anthropological diplomacy, including the impact of diverse…

Articulated, Performance-Based Instruction Objectives Guide for Machine Shop Technology.

ERIC Educational Resources Information Center

Henderson, William Edward, Jr., Ed.

This articulation guide contains 21 units of instruction for two years of machine shop. The objectives of the program are to provide the student with the basic terminology and fundamental knowledge and skills in machining (year 1) and to teach him/her to set up and operate machine tools and make or repair metal parts, tools, and machines (year 2).…

A language based on the fundamental facts of science.

PubMed

Devito, C L; Oehrle, R T

1990-12-01

The problem of how to communicate with the members of an alien society has been discussed by many authors but only one, Hans Freudenthal, has constructed a language for this purpose. Freudenthal assumes nothing other than the ability to reason as humans do and, because he assumes so little, it is necessary to communicate a great deal about the language itself before being able to communicate any interesting information. The problem is here approached differently. Since it is likely that contact between our civilization and an alien one would be via radio, potential correspondents would have a basic knowledge of science. Such beings should therefore be able to learn a language based on fundamental science. It is assumed, more specifically, that our correspondents can count, understand chemical elements, are familiar with the melting and boiling behaviour of a pure substance and understand the properties of the gaseous state. All this should be known to any society capable of developing the radio telescope. By systematically using this common knowledge one can communicate notation for numbers and chemical elements and then communicate our basic physical units; i.e., the gram, the calorie, the degree (Kelvin), etc. Once this is done more interesting information can be exchanged.

Summaries of FY 1996 geosciences research

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1996-12-01

The Geosciences Research Program is directed by the Department of Energy`s (DOE`s) Office of Energy Research (OER) through its Office of Basic Energy Sciences (OBES). Activities in the Geosciences Research Program are directed toward building the long-term fundamental knowledge base necessary to provide for energy technologies of the future. Future energy technologies and their individual roles in satisfying the nations energy needs cannot be easily predicted. It is clear, however, that these future energy technologies will involve consumption of energy and mineral resources and generation of technological wastes. The earth is a source for energy and mineral resources and ismore » also the host for wastes generated by technological enterprise. Viable energy technologies for the future must contribute to a national energy enterprise that is efficient, economical, and environmentally sound. The Geosciences Research Program emphasizes research leading to fundamental knowledge of the processes that transport, modify, concentrate, and emplace (1) the energy and mineral resources of the earth and (2) the energy by-products of man.« less

Knowledge, as the Result of the Processed Information by Human's Sub-particles (substrings)/Mind in our Brain

NASA Astrophysics Data System (ADS)

Gholibeigian, Hassan

In my vision, there are four animated sub-particles (mater, plant, animal and human sub-particles) as the origin of the life and creator of momentum in each fundamental particle (string). They communicate with dimension of information which is nested with space-time for getting a package of information in each Planck time. They are link-point between dimension of information and space-time. Sub-particle which identifies its fundamental particle, processes the package of information for finding its next step. Processed information carry always by fundamental particles as the history of the universe and enhance its entropy. My proposed formula for calculating number of packages is I =tP- 1 . τ , Planck time tP, and τ is fundamental particle's lifetime. For example a photon needs processes 1 . 8 ×1043 packages of information for finding its path in a second. Duration of each process is faster than light speed. In our bodies, human's sub-particles (substrings) communicate with dimension of information and get packages of information including standard ethics for process and finding their next step. The processed information transforms to knowledge in our mind. This knowledge is always carried by us. Knowledge, as the Result of the Processed Information by Human's Sub-particles (sub-strings)/Mind in our Brain.

Advanced techniques for the storage and use of very large, heterogeneous spatial databases. The representation of geographic knowledge: Toward a universal framework. [relations (mathematics)

NASA Technical Reports Server (NTRS)

Peuquet, Donna J.

1987-01-01

A new approach to building geographic data models that is based on the fundamental characteristics of the data is presented. An overall theoretical framework for representing geographic data is proposed. An example of utilizing this framework in a Geographic Information System (GIS) context by combining artificial intelligence techniques with recent developments in spatial data processing techniques is given. Elements of data representation discussed include hierarchical structure, separation of locational and conceptual views, and the ability to store knowledge at variable levels of completeness and precision.

Physical sciences research plans for the International Space Station.

PubMed

Trinh, E H

2003-01-01

The restructuring of the research capabilities of the International Space Station has forced a reassessment of the Physical Sciences research plans and a re-targeting of the major scientific thrusts. The combination of already selected peer-reviewed flight investigations with the initiation of new research and technology programs will allow the maximization of the ISS scientific and technological potential. Fundamental and applied research will use a combination of ISS-based facilities, ground-based activities, and other experimental platforms to address issues impacting fundamental knowledge, industrial and medical applications on Earth, and the technology required for human space exploration. The current flight investigation research plan shows a large number of principal investigators selected to use the remaining planned research facilities. c2003 American Institute of Aeronautics and Astronautics. Published by Elsevier Science Ltd. All rights reserved.

Physical sciences research plans for the International Space Station

NASA Technical Reports Server (NTRS)

Trinh, E. H.

2003-01-01

The restructuring of the research capabilities of the International Space Station has forced a reassessment of the Physical Sciences research plans and a re-targeting of the major scientific thrusts. The combination of already selected peer-reviewed flight investigations with the initiation of new research and technology programs will allow the maximization of the ISS scientific and technological potential. Fundamental and applied research will use a combination of ISS-based facilities, ground-based activities, and other experimental platforms to address issues impacting fundamental knowledge, industrial and medical applications on Earth, and the technology required for human space exploration. The current flight investigation research plan shows a large number of principal investigators selected to use the remaining planned research facilities. c2003 American Institute of Aeronautics and Astronautics. Published by Elsevier Science Ltd. All rights reserved.

Strategies for Mentoring Pedagogical Knowledge

ERIC Educational Resources Information Center

Hudson, Peter

2013-01-01

Fundamental for mentoring a preservice teacher is the mentor's articulation of pedagogical knowledge, which in this research draws upon specific practices, viz.: planning, timetabling lessons, preparation, teaching strategies, content knowledge, problem solving, questioning, classroom management, implementation, assessment and viewpoints for…

Computer sciences

NASA Technical Reports Server (NTRS)

Smith, Paul H.

1988-01-01

The Computer Science Program provides advanced concepts, techniques, system architectures, algorithms, and software for both space and aeronautics information sciences and computer systems. The overall goal is to provide the technical foundation within NASA for the advancement of computing technology in aerospace applications. The research program is improving the state of knowledge of fundamental aerospace computing principles and advancing computing technology in space applications such as software engineering and information extraction from data collected by scientific instruments in space. The program includes the development of special algorithms and techniques to exploit the computing power provided by high performance parallel processors and special purpose architectures. Research is being conducted in the fundamentals of data base logic and improvement techniques for producing reliable computing systems.

Knowledge Management Systems: Linking Contribution, Refinement and Use

ERIC Educational Resources Information Center

Chung, Ting-ting

2009-01-01

Electronic knowledge repositories represent one of the fundamental tools for knowledge management (KM) initiatives. Existing research, however, has largely focused on supply-side driven research questions, such as employee motivation to contribute knowledge to a repository. This research turns attention to the dynamic relationship between the…

Active Computer Network Defense: An Assessment

DTIC Science & Technology

2001-04-01

sufficient base of knowledge in information technology can be assumed to be working on some form of computer network warfare, even if only defensive in...the Defense Information Infrastructure (DII) to attack. Transmission Control Protocol/ Internet Protocol (TCP/IP) networks are inherently resistant to...aims to create this part of information superiority, and computer network defense is one of its fundamental components. Most of these efforts center

The Relationship between Student Success and the Learning-Centered Leadership Behaviors of Principals in Southeast Louisiana

ERIC Educational Resources Information Center

Tuttleton, Jennifer Lee Grice

2013-01-01

The importance of education is realized in all facets of life given the direct link between poverty and poor educational outcomes. Education is a rudimentary need; an individual will face many barriers and impediments in life without a sound knowledge base and strong literacy skills. This is the fundamental reason why there has been a considerable…

Meeting the Discipline-Culture Framework of Physics Knowledge: A Teaching Experience in Italian Secondary School

NASA Astrophysics Data System (ADS)

Levrini, Olivia; Bertozzi, Eugenio; Gagliardi, Marta; Tomasini, Nella Grimellini; Pecori, Barbara; Tasquier, Giulia; Galili, Igal

2014-09-01

The paper deals with physics teaching/learning in high school. An investigation in three upper secondary school classes in Italy explored the reactions of students to a structuring lecture on optics within the discipline-culture (DC) framework that organises physics knowledge around four interrelated fundamental theories of light. The lecture presented optics as an unfolding conceptual discourse of physicists regarding the nature of light. Along with the knowledge constructed in a school course of a scientific lyceum, the students provided epistemological comments, displaying their perception of physics knowledge presented in the classroom. Students' views and knowledge were investigated by questionnaires prior to and after the lecture and in special discussions held in each class. They revealed a variety of attitudes and views which allowed inferences about the potential of the DC framework in an educational context. The findings and interpretation indicate the positive and stimulating impact of the lecture and the way in which DC-based approach to knowledge organization makes physics at school cultural and attractive.

Assessing the Science Knowledge of University Students: Perils, Pitfalls and Possibilities

ERIC Educational Resources Information Center

Jones, Susan M.

2014-01-01

Science content knowledge is internationally regarded as a fundamentally important learning outcome for graduates of bachelor level science degrees: the Science Threshold Learning Outcomes (TLOs) recently adopted in Australia as a nationally agreed framework include "Science Knowledge" as TLO 2. Science knowledge is commonly assessed…

Knowledge diffusion of dynamical network in terms of interaction frequency.

PubMed

Liu, Jian-Guo; Zhou, Qing; Guo, Qiang; Yang, Zhen-Hua; Xie, Fei; Han, Jing-Ti

2017-09-07

In this paper, we present a knowledge diffusion (SKD) model for dynamic networks by taking into account the interaction frequency which always used to measure the social closeness. A set of agents, which are initially interconnected to form a random network, either exchange knowledge with their neighbors or move toward a new location through an edge-rewiring procedure. The activity of knowledge exchange between agents is determined by a knowledge transfer rule that the target node would preferentially select one neighbor node to transfer knowledge with probability p according to their interaction frequency instead of the knowledge distance, otherwise, the target node would build a new link with its second-order neighbor preferentially or select one node in the system randomly with probability 1 - p. The simulation results show that, comparing with the Null model defined by the random selection mechanism and the traditional knowledge diffusion (TKD) model driven by knowledge distance, the knowledge would spread more fast based on SKD driven by interaction frequency. In particular, the network structure of SKD would evolve as an assortative one, which is a fundamental feature of social networks. This work would be helpful for deeply understanding the coevolution of the knowledge diffusion and network structure.

Primary School Teachers' Interviews Regarding Pedagogical Content Knowledge (PCK) and General Pedagogical Knowledge (GPK)

ERIC Educational Resources Information Center

Sothayapetch, Pavinee; Lavonen, Jari; Juuti, Kalle

2013-01-01

Pedagogical Content Knowledge (PCK) and General Pedagogical Knowledge (GPK) are fundamental types of knowledge for a teacher that he or she must use in order to plan, teach in the classroom, and assess students' learning outcomes. This paper investigates experienced primary school teachers' PCK and GPK while teaching science in Finland and in…

Pilot Study Evaluating a Practice-Based Learning and Improvement Curriculum Focusing on the Development of System-Level Quality Improvement Skills

PubMed Central

Tomolo, Anne M; Lawrence, Renée H; Watts, Brook; Augustine, Sarah; Aron, David C; Singh, Mamta K

2011-01-01

Background We developed a practice-based learning and improvement (PBLI) curriculum to address important gaps in components of content and experiential learning activities through didactics and participation in systems-level quality improvement projects that focus on making changes in health care processes. Methods We evaluated the impact of our curriculum on resident PBLI knowledge, self-efficacy, and application skills. A quasi-experimental design assessed the impact of a curriculum (PBLI quality improvement systems compared with non-PBLI) on internal medicine residents' learning during a 4-week ambulatory block. We measured application skills, self-efficacy, and knowledge by using the Systems Quality Improvement Training and Assessment Tool. Exit evaluations assessed time invested and experiences related to the team projects and suggestions for improving the curriculum. Results The 2 groups showed differences in change scores. Relative to the comparison group, residents in the PBLI curriculum demonstrated a significant increase in the belief about their ability to implement a continuous quality improvement project (P  =  .020), comfort level in developing data collection plans (P  =  .010), and total knowledge scores (P < .001), after adjusting for prior PBLI experience. Participants in the PBLI curriculum also demonstrated significant improvement in providing a more complete aim statement for a proposed project after adjusting for prior PBLI experience (P  =  .001). Exit evaluations were completed by 96% of PBLI curriculum participants who reported high satisfaction with team performance. Conclusion Residents in our curriculum showed gains in areas fundamental for PBLI competency. The observed improvements were related to fundamental quality improvement knowledge, with limited gain in application skills. This suggests that while heading in the right direction, we need to conceptualize and structure PBLI training in a way that integrates it throughout the residency program and fosters the application of this knowledge and these skills. PMID:22379523

Pilot study evaluating a practice-based learning and improvement curriculum focusing on the development of system-level quality improvement skills.

PubMed

Tomolo, Anne M; Lawrence, Renée H; Watts, Brook; Augustine, Sarah; Aron, David C; Singh, Mamta K

2011-03-01

We developed a practice-based learning and improvement (PBLI) curriculum to address important gaps in components of content and experiential learning activities through didactics and participation in systems-level quality improvement projects that focus on making changes in health care processes. We evaluated the impact of our curriculum on resident PBLI knowledge, self-efficacy, and application skills. A quasi-experimental design assessed the impact of a curriculum (PBLI quality improvement systems compared with non-PBLI) on internal medicine residents' learning during a 4-week ambulatory block. We measured application skills, self-efficacy, and knowledge by using the Systems Quality Improvement Training and Assessment Tool. Exit evaluations assessed time invested and experiences related to the team projects and suggestions for improving the curriculum. The 2 groups showed differences in change scores. Relative to the comparison group, residents in the PBLI curriculum demonstrated a significant increase in the belief about their ability to implement a continuous quality improvement project (P  =  .020), comfort level in developing data collection plans (P  =  .010), and total knowledge scores (P < .001), after adjusting for prior PBLI experience. Participants in the PBLI curriculum also demonstrated significant improvement in providing a more complete aim statement for a proposed project after adjusting for prior PBLI experience (P  =  .001). Exit evaluations were completed by 96% of PBLI curriculum participants who reported high satisfaction with team performance. Residents in our curriculum showed gains in areas fundamental for PBLI competency. The observed improvements were related to fundamental quality improvement knowledge, with limited gain in application skills. This suggests that while heading in the right direction, we need to conceptualize and structure PBLI training in a way that integrates it throughout the residency program and fosters the application of this knowledge and these skills.

Arteriovenous Malformations and Other Vascular Lesions of the Central Nervous System

MedlinePlus

... Neurological Disorders and Stroke (NINDS) is to seek fundamental knowledge about the brain and spinal cord and ... NINDS-funded research hopes to determine molecular pathways fundamental to the formation of brain AVMs, which may ...

Application of Fuzzy Analytic Hierarchy Process to Building Research Teams

NASA Astrophysics Data System (ADS)

Dąbrowski, Karol; Skrzypek, Katarzyna

2016-03-01

Building teams has a fundamental impact for execution of research and development projects. The teams appointed for the needs of given projects are based on individuals from both inside and outside of the organization. Knowledge is not only a product available on the market but also an intangible resource affecting their internal and external processes. Thus it is vitally important for businesses and scientific research facilities to effectively manage knowledge within project teams. The article presents a proposal to use Fuzzy AHP (Analytic Hierarchy Process) and ANFIS (Adaptive Neuro Fuzzy Inference System) methods in working groups building for R&D projects on the basis of employees skills.

Chapter 1: Biomedical knowledge integration.

PubMed

Payne, Philip R O

2012-01-01

The modern biomedical research and healthcare delivery domains have seen an unparalleled increase in the rate of innovation and novel technologies over the past several decades. Catalyzed by paradigm-shifting public and private programs focusing upon the formation and delivery of genomic and personalized medicine, the need for high-throughput and integrative approaches to the collection, management, and analysis of heterogeneous data sets has become imperative. This need is particularly pressing in the translational bioinformatics domain, where many fundamental research questions require the integration of large scale, multi-dimensional clinical phenotype and bio-molecular data sets. Modern biomedical informatics theory and practice has demonstrated the distinct benefits associated with the use of knowledge-based systems in such contexts. A knowledge-based system can be defined as an intelligent agent that employs a computationally tractable knowledge base or repository in order to reason upon data in a targeted domain and reproduce expert performance relative to such reasoning operations. The ultimate goal of the design and use of such agents is to increase the reproducibility, scalability, and accessibility of complex reasoning tasks. Examples of the application of knowledge-based systems in biomedicine span a broad spectrum, from the execution of clinical decision support, to epidemiologic surveillance of public data sets for the purposes of detecting emerging infectious diseases, to the discovery of novel hypotheses in large-scale research data sets. In this chapter, we will review the basic theoretical frameworks that define core knowledge types and reasoning operations with particular emphasis on the applicability of such conceptual models within the biomedical domain, and then go on to introduce a number of prototypical data integration requirements and patterns relevant to the conduct of translational bioinformatics that can be addressed via the design and use of knowledge-based systems.

Chapter 1: Biomedical Knowledge Integration

PubMed Central

Payne, Philip R. O.

2012-01-01

The modern biomedical research and healthcare delivery domains have seen an unparalleled increase in the rate of innovation and novel technologies over the past several decades. Catalyzed by paradigm-shifting public and private programs focusing upon the formation and delivery of genomic and personalized medicine, the need for high-throughput and integrative approaches to the collection, management, and analysis of heterogeneous data sets has become imperative. This need is particularly pressing in the translational bioinformatics domain, where many fundamental research questions require the integration of large scale, multi-dimensional clinical phenotype and bio-molecular data sets. Modern biomedical informatics theory and practice has demonstrated the distinct benefits associated with the use of knowledge-based systems in such contexts. A knowledge-based system can be defined as an intelligent agent that employs a computationally tractable knowledge base or repository in order to reason upon data in a targeted domain and reproduce expert performance relative to such reasoning operations. The ultimate goal of the design and use of such agents is to increase the reproducibility, scalability, and accessibility of complex reasoning tasks. Examples of the application of knowledge-based systems in biomedicine span a broad spectrum, from the execution of clinical decision support, to epidemiologic surveillance of public data sets for the purposes of detecting emerging infectious diseases, to the discovery of novel hypotheses in large-scale research data sets. In this chapter, we will review the basic theoretical frameworks that define core knowledge types and reasoning operations with particular emphasis on the applicability of such conceptual models within the biomedical domain, and then go on to introduce a number of prototypical data integration requirements and patterns relevant to the conduct of translational bioinformatics that can be addressed via the design and use of knowledge-based systems. PMID:23300416

Leveraging a Sorting Task as a Measure of Knowledge Structure in Bilingual Settings

ERIC Educational Resources Information Center

Tang, Hengtao; Clariana, Roy

2017-01-01

This descriptive exploratory study considers whether a simple sorting task can elicit readers' knowledge structure in learners' first and second language. In this investigation, knowledge structure is considered from a symbolic connectionist viewpoint as the fundamental pre-meaningful aspect of knowledge, where structure is the precursor of…

On the Performance Characteristics of Latent-Factor and Knowledge Tracing Models

ERIC Educational Resources Information Center

Klingler, Severin; Käser, Tanja; Solenthaler, Barbara; Gross, Markus

2015-01-01

Modeling student knowledge is a fundamental task of an intelligent tutoring system. A popular approach for modeling the acquisition of knowledge is Bayesian Knowledge Tracing (BKT). Various extensions to the original BKT model have been proposed, among them two novel models that unify BKT and Item Response Theory (IRT). Latent Factor Knowledge…

Characterizing and Representing Student's Conceptual Knowledge of Chemical Bonding

ERIC Educational Resources Information Center

Yayon, Malka; Mamlok-Naaman, Rachel; Fortus, David

2012-01-01

Chemical bonding knowledge is fundamental and essential to the understanding of almost every topic in chemistry, but it is very difficult to learn. While many studies have characterized some of the central elements of knowledge of this topic, these elements of knowledge have not been systematically organized. We describe the development and…

Damaging earthquakes: A scientific laboratory

USGS Publications Warehouse

Hays, Walter W.; ,

1996-01-01

This paper reviews the principal lessons learned from multidisciplinary postearthquake investigations of damaging earthquakes throughout the world during the past 15 years. The unique laboratory provided by a damaging earthquake in culturally different but tectonically similar regions of the world has increased fundamental understanding of earthquake processes, added perishable scientific, technical, and socioeconomic data to the knowledge base, and led to changes in public policies and professional practices for earthquake loss reduction.

Exploring the Relationship between Secondary Science Teachers' Subject Matter Knowledge and Knowledge of Student Conceptions While Teaching Evolution by Natural Selection

ERIC Educational Resources Information Center

Lucero, Margaret M.; Petrosino, Anthony J.; Delgado, Cesar

2017-01-01

The fundamental scientific concept of evolution occurring by natural selection is home to many deeply held alternative conceptions and considered difficult to teach. Science teachers' subject matter knowledge (SMK) and the pedagogical content knowledge (PCK) component of knowledge of students' conceptions (KOSC) can be valuable resources for…

Teaching hydrogeology: a review of current practice

NASA Astrophysics Data System (ADS)

Gleeson, T.; Allen, D. M.; Ferguson, G.

2012-07-01

Hydrogeology is now taught in a broad spectrum of departments and institutions to students with diverse backgrounds. Successful instruction in hydrogeology thus requires a variety of pedagogical approaches depending on desired learning outcomes and the background of students. We review the pedagogical literature in hydrogeology to highlight recent advances and analyze a 2005 survey among 68 hydrogeology instructors. The literature and survey results suggest there are only ~ 15 topics that are considered crucial by most hydrogeologists and > 100 other topics that are considered crucial by some hydrogeologists. The crucial topics focus on properties of aquifers and fundamentals of groundwater flow, and should likely be part of all undergraduate hydrogeology courses. Other topics can supplement and support these crucial topics, depending on desired learning outcomes. Classroom settings continue to provide a venue for emphasizing fundamental knowledge. However, recent pedagogical advances are biased towards field and laboratory instruction with a goal of bolstering experiential learning. Field methods build on the fundamentals taught in the classroom and emphasize the collection of data, data uncertainty, and the development of vocational skills. Laboratory and computer-based exercises similarly build on theory, and offer an opportunity for data analysis and integration. The literature suggests curricula at all levels should ideally balance field, laboratory, and classroom pedagogy into an iterative and integrative whole. An integrated, iterative and balanced approach leads to greater student motivation and advancement of theoretical and vocational knowledge.

Flowing with the changing needs of hydrogeology instruction

NASA Astrophysics Data System (ADS)

Gleeson, T.; Allen, D. M.; Ferguson, G.

2012-01-01

Hydrogeology is now taught in a broad spectrum of departments and institutions to students with diverse backgrounds. Successful instruction in hydrogeology thus requires a variety of pedagogical approaches depending on desired learning outcomes and the diverse background of students. We review the pedagogical literature in hydrogeology to highlight recent advances and analyze a 2005 survey of 68 hydrogeology instructors. The literature and survey results suggest there are ~15 topics that are considered crucial by most hydrogeologists and >100 other topics that are considered crucial by some hydrogeologists. The crucial topics focus on properties of aquifers and fundamentals of groundwater flow, and should likely be part of all undergraduate hydrogeology courses. Other topics can supplement and support these crucial topics, depending on desired learning outcomes. Classroom settings continue to provide a venue for emphasizing fundamental knowledge. However, recent pedagogical advances are biased towards field and laboratory instruction with a goal of bolstering experiential learning. Field methods build on the fundamentals taught in the classroom and emphasize the collection of data, data uncertainty, and the development of vocational skills. Laboratory and computer-based exercises similarly build on theory, and offer an opportunity for data analysis and integration. The literature suggests curricula at all levels should ideally balance field, laboratory, and classroom pedagogy into an iterative and integrative whole. An integrated approach leads to greater student motivation and advancement of theoretical and vocational knowledge.

Fundamental concepts of problem-based learning for the new facilitator.

PubMed Central

Kanter, S L

1998-01-01

Problem-based learning (PBL) is a powerful small group learning tool that should be part of the armamentarium of every serious educator. Classic PBL uses ill-structured problems to simulate the conditions that occur in the real environment. Students play an active role and use an iterative process of seeking new information based on identified learning issues, restructuring the information in light of the new knowledge, gathering additional information, and so forth. Faculty play a facilitatory role, not a traditional instructional role, by posing metacognitive questions to students. These questions serve to assist in organizing, generalizing, and evaluating knowledge; to probe for supporting evidence; to explore faulty reasoning; to stimulate discussion of attitudes; and to develop self-directed learning and self-assessment skills. Professional librarians play significant roles in the PBL environment extending from traditional service provider to resource person to educator. Students and faculty usually find the learning experience productive and enjoyable. PMID:9681175

A psychologically-based taxonomy of misdirection

PubMed Central

Kuhn, Gustav; Caffaratti, Hugo A.; Teszka, Robert; Rensink, Ronald A.

2014-01-01

Magicians use misdirection to prevent you from realizing the methods used to create a magical effect, thereby allowing you to experience an apparently impossible event. Magicians have acquired much knowledge about misdirection, and have suggested several taxonomies of misdirection. These describe many of the fundamental principles in misdirection, focusing on how misdirection is achieved by magicians. In this article we review the strengths and weaknesses of past taxonomies, and argue that a more natural way of making sense of misdirection is to focus on the perceptual and cognitive mechanisms involved. Our psychologically-based taxonomy has three basic categories, corresponding to the types of psychological mechanisms affected: perception, memory, and reasoning. Each of these categories is then divided into subcategories based on the mechanisms that control these effects. This new taxonomy can help organize magicians' knowledge of misdirection in a meaningful way, and facilitate the dialog between magicians and scientists. PMID:25538648

Reading for meaning: The foundational knowledge every teacher of science should have

NASA Astrophysics Data System (ADS)

Patterson, Alexis; Roman, Diego; Friend, Michelle; Osborne, Jonathan; Donovan, Brian

2018-02-01

Reading is fundamental to science and not an adjunct to its practice. In other words, understanding the meaning of the various forms of written discourse employed in the creation, discussion, and communication of scientific knowledge is inherent to how science works. The language used in science, however, sets up a barrier, that in order to be overcome requires all students to have a clear understanding of the features of the multimodal informational texts employed in science and the strategies they can use to decode the scientific concepts communicated in informational texts. We argue that all teachers of science must develop a functional understanding of reading comprehension as part of their professional knowledge and skill. After describing our rationale for including knowledge about reading as a professional knowledge base every teacher of science should have, we outline the knowledge about language teachers must develop, the knowledge about the challenges that reading comprehension of science texts poses for students, and the knowledge about instructional strategies science teachers should know to support their students' reading comprehension of science texts. Implications regarding the essential role that knowledge about reading should play in the preparation of science teachers are also discussed here.

Fairness in Knowing: Science Communication and Epistemic Justice.

PubMed

Medvecky, Fabien

2017-09-22

Science communication, as a field and as a practice, is fundamentally about knowledge distribution; it is about the access to, and the sharing of knowledge. All distribution (science communication included) brings with it issues of ethics and justice. Indeed, whether science communicators acknowledge it or not, they get to decide both which knowledge is shared (by choosing which topic is communicated), and who gets access to this knowledge (by choosing which audience it is presented to). As a result, the decisions of science communicators have important implications for epistemic justice: how knowledge is distributed fairly and equitably. This paper presents an overview of issues related to epistemic justice for science communication, and argues that there are two quite distinct ways in which science communicators can be just (or unjust) in the way they distribute knowledge. Both of these paths will be considered before concluding that, at least on one of these accounts, science communication as a field and as a practice is fundamentally epistemically unjust. Possible ways to redress this injustice are suggested.

Design of electrocatalysts for oxygen- and hydrogen-involving energy conversion reactions.

PubMed

Jiao, Yan; Zheng, Yao; Jaroniec, Mietek; Qiao, Shi Zhang

2015-04-21

A fundamental change has been achieved in understanding surface electrochemistry due to the profound knowledge of the nature of electrocatalytic processes accumulated over the past several decades and to the recent technological advances in spectroscopy and high resolution imaging. Nowadays one can preferably design electrocatalysts based on the deep theoretical knowledge of electronic structures, via computer-guided engineering of the surface and (electro)chemical properties of materials, followed by the synthesis of practical materials with high performance for specific reactions. This review provides insights into both theoretical and experimental electrochemistry toward a better understanding of a series of key clean energy conversion reactions including oxygen reduction reaction (ORR), oxygen evolution reaction (OER), and hydrogen evolution reaction (HER). The emphasis of this review is on the origin of the electrocatalytic activity of nanostructured catalysts toward the aforementioned reactions by correlating the apparent electrode performance with their intrinsic electrochemical properties. Also, a rational design of electrocatalysts is proposed starting from the most fundamental aspects of the electronic structure engineering to a more practical level of nanotechnological fabrication.

Correlation analysis of the physiological factors controlling fundamental voice frequency.

PubMed

Atkinson, J E

1978-01-01

A technique has been developed to obtain a quantitative measure of correlation between electromyographic (EMG) activity of various laryngeal muscles, subglottal air pressure, and the fundamental frequency of vibration of the vocal folds (Fo). Data were collected and analyzed on one subject, a native speaker of American English. The results show that an analysis of this type can provide a useful measure of correlation between the physiological and acoustical events in speech and, furthermore, can yield detailed insights into the organization and nature of the speech production process. In particular, based on these results, a model is suggested of Fo control involving laryngeal state functions that seems to agree with present knowledge of laryngeal control and experimental evidence.

Using ontologies to model human navigation behavior in information networks: A study based on Wikipedia.

PubMed

Lamprecht, Daniel; Strohmaier, Markus; Helic, Denis; Nyulas, Csongor; Tudorache, Tania; Noy, Natalya F; Musen, Mark A

The need to examine the behavior of different user groups is a fundamental requirement when building information systems. In this paper, we present Ontology-based Decentralized Search (OBDS), a novel method to model the navigation behavior of users equipped with different types of background knowledge. Ontology-based Decentralized Search combines decentralized search, an established method for navigation in social networks, and ontologies to model navigation behavior in information networks. The method uses ontologies as an explicit representation of background knowledge to inform the navigation process and guide it towards navigation targets. By using different ontologies, users equipped with different types of background knowledge can be represented. We demonstrate our method using four biomedical ontologies and their associated Wikipedia articles. We compare our simulation results with base line approaches and with results obtained from a user study. We find that our method produces click paths that have properties similar to those originating from human navigators. The results suggest that our method can be used to model human navigation behavior in systems that are based on information networks, such as Wikipedia. This paper makes the following contributions: (i) To the best of our knowledge, this is the first work to demonstrate the utility of ontologies in modeling human navigation and (ii) it yields new insights and understanding about the mechanisms of human navigation in information networks.

Using ontologies to model human navigation behavior in information networks: A study based on Wikipedia

PubMed Central

Lamprecht, Daniel; Strohmaier, Markus; Helic, Denis; Nyulas, Csongor; Tudorache, Tania; Noy, Natalya F.; Musen, Mark A.

2015-01-01

The need to examine the behavior of different user groups is a fundamental requirement when building information systems. In this paper, we present Ontology-based Decentralized Search (OBDS), a novel method to model the navigation behavior of users equipped with different types of background knowledge. Ontology-based Decentralized Search combines decentralized search, an established method for navigation in social networks, and ontologies to model navigation behavior in information networks. The method uses ontologies as an explicit representation of background knowledge to inform the navigation process and guide it towards navigation targets. By using different ontologies, users equipped with different types of background knowledge can be represented. We demonstrate our method using four biomedical ontologies and their associated Wikipedia articles. We compare our simulation results with base line approaches and with results obtained from a user study. We find that our method produces click paths that have properties similar to those originating from human navigators. The results suggest that our method can be used to model human navigation behavior in systems that are based on information networks, such as Wikipedia. This paper makes the following contributions: (i) To the best of our knowledge, this is the first work to demonstrate the utility of ontologies in modeling human navigation and (ii) it yields new insights and understanding about the mechanisms of human navigation in information networks. PMID:26568745

A Comparison of Functional Models for Use in the Function-Failure Design Method

NASA Technical Reports Server (NTRS)

Stock, Michael E.; Stone, Robert B.; Tumer, Irem Y.

2006-01-01

When failure analysis and prevention, guided by historical design knowledge, are coupled with product design at its conception, shorter design cycles are possible. By decreasing the design time of a product in this manner, design costs are reduced and the product will better suit the customer s needs. Prior work indicates that similar failure modes occur with products (or components) with similar functionality. To capitalize on this finding, a knowledge base of historical failure information linked to functionality is assembled for use by designers. One possible use for this knowledge base is within the Elemental Function-Failure Design Method (EFDM). This design methodology and failure analysis tool begins at conceptual design and keeps the designer cognizant of failures that are likely to occur based on the product s functionality. The EFDM offers potential improvement over current failure analysis methods, such as FMEA, FMECA, and Fault Tree Analysis, because it can be implemented hand in hand with other conceptual design steps and carried throughout a product s design cycle. These other failure analysis methods can only truly be effective after a physical design has been completed. The EFDM however is only as good as the knowledge base that it draws from, and therefore it is of utmost importance to develop a knowledge base that will be suitable for use across a wide spectrum of products. One fundamental question that arises in using the EFDM is: At what level of detail should functional descriptions of components be encoded? This paper explores two approaches to populating a knowledge base with actual failure occurrence information from Bell 206 helicopters. Functional models expressed at various levels of detail are investigated to determine the necessary detail for an applicable knowledge base that can be used by designers in both new designs as well as redesigns. High level and more detailed functional descriptions are derived for each failed component based on NTSB accident reports. To best record this data, standardized functional and failure mode vocabularies are used. Two separate function-failure knowledge bases are then created aid compared. Results indicate that encoding failure data using more detailed functional models allows for a more robust knowledge base. Interestingly however, when applying the EFDM, high level descriptions continue to produce useful results when using the knowledge base generated from the detailed functional models.

The Impact of Secondary School Students' Preconceptions on the Evolution of their Mental Models of the Greenhouse effect and Global Warming

NASA Astrophysics Data System (ADS)

Reinfried, Sibylle; Tempelmann, Sebastian

2014-01-01

This paper provides a video-based learning process study that investigates the kinds of mental models of the atmospheric greenhouse effect 13-year-old learners have and how these mental models change with a learning environment, which is optimised in regard to instructional psychology. The objective of this explorative study was to observe and analyse the learners' learning pathways according to their previous knowledge in detail and to understand the mental model formation processes associated with them more precisely. For the analysis of the learning pathways, drawings, texts, video and interview transcripts from 12 students were studied using qualitative methods. The learning pathways pursued by the learners significantly depend on their domain-specific previous knowledge. The learners' preconceptions could be typified based on specific characteristics, whereby three preconception types could be formed. The 'isolated pieces of knowledge' type of learners, who have very little or no previous knowledge about the greenhouse effect, build new mental models that are close to the target model. 'Reduced heat output' type of learners, who have previous knowledge that indicates compliances with central ideas of the normative model, reconstruct their knowledge by reorganising and interpreting their existing knowledge structures. 'Increasing heat input' type of learners, whose previous knowledge consists of subjective worldly knowledge, which has a greater personal explanatory value than the information from the learning environment, have more difficulties changing their mental models. They have to fundamentally reconstruct their mental models.

Toward translational incremental similarity-based reasoning in breast cancer grading

NASA Astrophysics Data System (ADS)

Tutac, Adina E.; Racoceanu, Daniel; Leow, Wee-Keng; Müller, Henning; Putti, Thomas; Cretu, Vladimir

2009-02-01

One of the fundamental issues in bridging the gap between the proliferation of Content-Based Image Retrieval (CBIR) systems in the scientific literature and the deficiency of their usage in medical community is based on the characteristic of CBIR to access information by images or/and text only. Yet, the way physicians are reasoning about patients leads intuitively to a case representation. Hence, a proper solution to overcome this gap is to consider a CBIR approach inspired by Case-Based Reasoning (CBR), which naturally introduces medical knowledge structured by cases. Moreover, in a CBR system, the knowledge is incrementally added and learned. The purpose of this study is to initiate a translational solution from CBIR algorithms to clinical practice, using a CBIR/CBR hybrid approach. Therefore, we advance the idea of a translational incremental similarity-based reasoning (TISBR), using combined CBIR and CBR characteristics: incremental learning of medical knowledge, medical case-based structure of the knowledge (CBR), image usage to retrieve similar cases (CBIR), similarity concept (central for both paradigms). For this purpose, three major axes are explored: the indexing, the cases retrieval and the search refinement, applied to Breast Cancer Grading (BCG), a powerful breast cancer prognosis exam. The effectiveness of this strategy is currently evaluated over cases provided by the Pathology Department of Singapore National University Hospital, for the indexing. With its current accuracy, TISBR launches interesting perspectives for complex reasoning in future medical research, opening the way to a better knowledge traceability and a better acceptance rate of computer-aided diagnosis assistance among practitioners.

Fundamental Use of Surgical Energy (FUSE): An Essential Educational Program for Operating Room Safety

PubMed Central

Jones, Stephanie B; Munro, Malcolm G; Feldman, Liane S; Robinson, Thomas N; Brunt, L Michael; Schwaitzberg, Steven D; Jones, Daniel B; Fuchshuber, Pascal R

2017-01-01

Operating room (OR) safety has become a major concern in patient safety since the 1990s. Improvement of team communication and behavior is a popular target for safety programming at the institutional level. Despite these efforts, essential safety gaps remain in the OR and procedure rooms. A prime example is the use of energy-based devices in ORs and procedural areas. The lack of fundamental understanding of energy device function, design, and application contributes to avoidable injury and harm at a rate of approximately 1 to 2 per 1000 patients in the US. Hundreds of OR fires occur each year in the US, some causing severe injury and even death. Most of these fires are associated with the use of energy-based surgical devices. In response to this safety issue, the Society of American Gastrointestinal and Endoscopic Surgeons (SAGES) developed the Fundamental Use of Surgical Energy (FUSE) program. This program includes a standardized curriculum targeted to surgeons, other physicians, and allied health care professionals and a psychometrically designed and validated certification test. A successful FUSE certification documents acquisition of the basic knowledge needed to safely use energy-based devices in the OR. By design FUSE fills a void in the curriculum and competency assessment for surgeons and other procedural specialists in the use of energy-based devices in patients. PMID:28241913

Ecological Knowledge Among Communities, Managers and Scientists: Bridging Divergent Perspectives to Improve Forest Management Outcomes

NASA Astrophysics Data System (ADS)

Rist, Lucy; Shackleton, Charlie; Gadamus, Lily; Chapin, F. Stuart; Gowda, C. Made; Setty, Siddappa; Kannan, Ramesh; Shaanker, R. Uma

2016-04-01

Multiple actors are typically involved in forest management, namely communities, managers and researchers. In such cases, suboptimal management outcomes may, in addition to other factors, be symptomatic of a divergence in perspectives among these actors driven by fundamental differences in ecological knowledge. We examine the degree of congruence between the understandings of actors surrounding key issues of management concern in three case studies from tropical, subtropical and boreal forests. We identify commonly encountered points of divergence in ecological knowledge relating to key management processes and issues. We use these to formulate seven hypotheses about differences in the bodies of knowledge that frequently underlie communication and learning failures in forest management contexts where multiple actors are involved and outcomes are judged to be suboptimal. Finally, we present a set of propositions to acknowledge and narrow these differences. A more complete recognition of the full triangulation between all actors involved, and of the influence that fundamental differences in ecological knowledge can exert, may help lead to a more fruitful integration between local knowledge and practice, manager knowledge and practice, and contemporary science in forest management.

Fundamental principles in periodontal plastic surgery and mucosal augmentation--a narrative review.

PubMed

Burkhardt, Rino; Lang, Niklaus P

2014-04-01

To provide a narrative review of the current literature elaborating on fundamental principles of periodontal plastic surgical procedures. Based on a presumptive outline of the narrative review, MESH terms have been used to search the relevant literature electronically in the PubMed and Cochrane Collaboration databases. If possible, systematic reviews were included. The review is divided into three phases associated with periodontal plastic surgery: a) pre-operative phase, b) surgical procedures and c) post-surgical care. The surgical procedures were discussed in the light of a) flap design and preparation, b) flap mobilization and c) flap adaptation and stabilization. Pre-operative paradigms include the optimal plaque control and smoking counselling. Fundamental principles in surgical procedures address basic knowledge in anatomy and vascularity, leading to novel appropriate flap designs with papilla preservation. Flap mobilization based on releasing incisions can be performed up to 5 mm. Flap adaptation and stabilization depend on appropriate wound bed characteristics, undisturbed blood clot formation, revascularization and wound stability through adequate suturing. Delicate tissue handling and tension free wound closure represent prerequisites for optimal healing outcomes. © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Impact of space on science

NASA Technical Reports Server (NTRS)

Elachi, Charles

1993-01-01

The advent of the capability to conduct space-based measurements has revolutionized the study of the Earth, the planetary system and the astrophysical universe. The resultant knowledge has yielded insights into the management of our planet's resources and provides intellectual enrichment for our civilization. New investigation techniques hold promise for extending the scope of space science to address topics in fundamental physics such as gravitational waves and certain aspects of Einstein's Theory of General Relativity.

Deaf Learners' Knowledge of English Universal Quantifiers

ERIC Educational Resources Information Center

Berent, Gerald P.; Kelly, Ronald R.; Porter, Jeffrey E.; Fonzi, Judith

2008-01-01

Deaf and hearing students' knowledge of English sentences containing universal quantifiers was compared through their performance on a 50-item, multiple-picture task that required students to decide whether each of five pictures represented a possible meaning of a target sentence. The task assessed fundamental knowledge of quantifier sentences,…

Digital Storytelling and the Nature of Knowledge

ERIC Educational Resources Information Center

Tan, Michael; Lee, Shu-Shing; Hung, David W.

2014-01-01

While storytelling pedagogy presents novel perspectives and affordances to educators, a fundamental question that bears attention is the match between storytelling pedagogy and the nature of knowledge. Quite simply, the problem may be posed thus: is storytelling the optimum means for teaching all forms of knowledge? While rather obvious matches…

Enhancing Teacher Beliefs through an Inquiry-Based Professional Development Program

PubMed Central

McKeown, Tammy R.; Abrams, Lisa M.; Slattum, Patricia W.; Kirk, Suzanne V.

2017-01-01

Inquiry-based instructional approaches are an effective means to actively engage students with science content and skills. This article examines the effects of an ongoing professional development program on middle and high school teachers’ efficacy beliefs, confidence to teach research concepts and skills, and science content knowledge. Professional development activities included participation in a week long summer academy, designing and implementing inquiry-based lessons within the classroom, examining and reflecting upon practices, and documenting ways in which instruction was modified. Teacher beliefs were assessed at three time points, pre- post- and six months following the summer academy. Results indicate significant gains in reported teaching efficacy, confidence, and content knowledge from pre- to post-test. These gains were maintained at the six month follow-up. Findings across the three different time points suggest that participation in the professional development program strongly influenced participants’ fundamental beliefs about their capacity to provide effective instruction in ways that are closely connected to the features of inquiry-based instruction. PMID:29732236

Enhancing Teacher Beliefs through an Inquiry-Based Professional Development Program.

PubMed

McKeown, Tammy R; Abrams, Lisa M; Slattum, Patricia W; Kirk, Suzanne V

2016-01-01

Inquiry-based instructional approaches are an effective means to actively engage students with science content and skills. This article examines the effects of an ongoing professional development program on middle and high school teachers' efficacy beliefs, confidence to teach research concepts and skills, and science content knowledge. Professional development activities included participation in a week long summer academy, designing and implementing inquiry-based lessons within the classroom, examining and reflecting upon practices, and documenting ways in which instruction was modified. Teacher beliefs were assessed at three time points, pre- post- and six months following the summer academy. Results indicate significant gains in reported teaching efficacy, confidence, and content knowledge from pre- to post-test. These gains were maintained at the six month follow-up. Findings across the three different time points suggest that participation in the professional development program strongly influenced participants' fundamental beliefs about their capacity to provide effective instruction in ways that are closely connected to the features of inquiry-based instruction.

[Teaching and learning the science of qualitative research in the health area].

PubMed

Calderón, Carlos

2012-03-01

Qualitative research constitutes a necessary perspective of knowledge within the field of health services. Healthcare always occurs in complex contexts and its enhancement requires research methodologies that address this complexity. Nevertheless, the knowledge and use of qualitative research in health services is still very limited. Among the different factors that affect its development, the teaching and learning of qualitative research proves to be fundamental, even beyond undergraduate education. Healthcare professionals and health services present certain specific aspects that must be considered in the design and development of the teaching and learning of qualitative research. Based on an eight-year online training experience with Primary Healthcare professionals, the main challenges are indentified and discussed.

Fuzzy logic in control systems: Fuzzy logic controller. I, II

NASA Technical Reports Server (NTRS)

Lee, Chuen Chien

1990-01-01

Recent advances in the theory and applications of fuzzy-logic controllers (FLCs) are examined in an analytical review. The fundamental principles of fuzzy sets and fuzzy logic are recalled; the basic FLC components (fuzzification and defuzzification interfaces, knowledge base, and decision-making logic) are described; and the advantages of FLCs for incorporating expert knowledge into a control system are indicated. Particular attention is given to fuzzy implication functions, the interpretation of sentence connectives (and, also), compositional operators, and inference mechanisms. Applications discussed include the FLC-guided automobile developed by Sugeno and Nishida (1985), FLC hardware systems, FLCs for subway trains and ship-loading cranes, fuzzy-logic chips, and fuzzy computers.

Management training in long-term care.

PubMed

Evashwick, Connie

2002-01-01

The education of health care administrators faces its most dramatic change since the inception of the field. Recent discussions at the national level call for major overhaul of curricula and teaching modalities, including moving education to position students for evidence-based practice. This paper presents recommendations for incorporating training about chronic and long-term care into health care management curricula. It asserts that all health care management students should have a basic knowledge of the fundamental policy, operating, and financing principles of long-term care. The majority of people using the health care delivery system today, and increasingly in the future, suffer from chronic conditions. Long-term care services, although less expansive in structure, far outnumber acute care services and health plans. They will grow in the future to meet the portending demand. To maximize job opportunities and to optimize performance in any job, health care administrators need to know about the long-term care delivery system. This paper delineates critical topics pertaining to long-term care, organized according to 11 fundamental management areas in which the field is developing core competencies. The contents were derived from a year-long process of asking stakeholders in the various facets of long-term care what topics they thought were essential for administrators to know. The topics delineated in this document represent the consensus about essential knowledge that all health care administrators should have about long-term care, whether specializing in long-term care or following a more general management career. The education of health care administrators faces its most dramatic change since the inception ofthe field. Recent discussions at the national level call for major overhaul of curricula and teaching modalities, including moving education to position students to perform according to evidence-based practice. It is thus timely to consider content, as well as educational format. This paper presents recommendations for incorporating training about chronic and long-term care into health care administration curricula. It asserts that all health care administration students should have a basic knowledge of the fundamental policy, operating, and financing principles of long-term care.

The "Making" of Knowledge Society in Rwanda? Translations, Tensions and Transformations

ERIC Educational Resources Information Center

Knutsson, Beniamin

2012-01-01

In the year 2000, Rwanda launched an ambitious long-term development strategy intended to render a fundamental transformation from an agrarian to a knowledge society by 2020. Knowledge society, however, could be viewed as a "floating signifier" open for a wide range of interpretations. Guided by a policy translation perspective the aim…

Inhibitory Control Interacts with Core Knowledge in Toddlers' Manual Search for an Occluded Object

ERIC Educational Resources Information Center

Baker, Sara T.; Gjersoe, Nathalia L.; Sibielska-Woch, Kasia; Leslie, Alan M.; Hood, Bruce M.

2011-01-01

Core knowledge theories advocate the primacy of fundamental principles that constrain cognitive development from early infancy. However, there is concern that core knowledge of object properties does not constrain older preschoolers' reasoning during manual search. Here we address in detail both failure and success on two well-established search…

Human Systems Integration Competency Development for Navy Systems Commands

DTIC Science & Technology

2012-09-01

cognizance of Applied Engineering /Psychology relative to knowledge engineering, training, teamwork, user interface design and decision sciences. KSA...cognizance of Applied Engineering /Psychology relative to knowledge engineering, training, teamwork, user interface design and decision sciences...requirements (as required). Fundamental cognizance of Applied Engineering / Psychology relative to knowledge engineering, training, team work, user

Gathering and Exploring Scientific Knowledge in Pharmacovigilance

PubMed Central

Lopes, Pedro; Nunes, Tiago; Campos, David; Furlong, Laura Ines; Bauer-Mehren, Anna; Sanz, Ferran; Carrascosa, Maria Carmen; Mestres, Jordi; Kors, Jan; Singh, Bharat; van Mulligen, Erik; Van der Lei, Johan; Diallo, Gayo; Avillach, Paul; Ahlberg, Ernst; Boyer, Scott; Diaz, Carlos; Oliveira, José Luís

2013-01-01

Pharmacovigilance plays a key role in the healthcare domain through the assessment, monitoring and discovery of interactions amongst drugs and their effects in the human organism. However, technological advances in this field have been slowing down over the last decade due to miscellaneous legal, ethical and methodological constraints. Pharmaceutical companies started to realize that collaborative and integrative approaches boost current drug research and development processes. Hence, new strategies are required to connect researchers, datasets, biomedical knowledge and analysis algorithms, allowing them to fully exploit the true value behind state-of-the-art pharmacovigilance efforts. This manuscript introduces a new platform directed towards pharmacovigilance knowledge providers. This system, based on a service-oriented architecture, adopts a plugin-based approach to solve fundamental pharmacovigilance software challenges. With the wealth of collected clinical and pharmaceutical data, it is now possible to connect knowledge providers’ analysis and exploration algorithms with real data. As a result, new strategies allow a faster identification of high-risk interactions between marketed drugs and adverse events, and enable the automated uncovering of scientific evidence behind them. With this architecture, the pharmacovigilance field has a new platform to coordinate large-scale drug evaluation efforts in a unique ecosystem, publicly available at http://bioinformatics.ua.pt/euadr/. PMID:24349421

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tokola, Ryan A; Mikkilineni, Aravind K; Boehnen, Chris Bensing

Despite being increasingly easy to acquire, 3D data is rarely used for face-based biometrics applications beyond identification. Recent work in image-based demographic biometrics has enjoyed much success, but these approaches suffer from the well-known limitations of 2D representations, particularly variations in illumination, texture, and pose, as well as a fundamental inability to describe 3D shape. This paper shows that simple 3D shape features in a face-based coordinate system are capable of representing many biometric attributes without problem-specific models or specialized domain knowledge. The same feature vector achieves impressive results for problems as diverse as age estimation, gender classification, and racemore » classification.« less

Recent progress of colloidal quantum dot based solar cells

NASA Astrophysics Data System (ADS)

Wei, Huiyun; Li, Dongmei; Zheng, Xinhe; Meng, Qingbo

2018-01-01

Not Available Project supported by the National Natural Science Foundation of China (Grant Nos. 61274134, 91433205, 51372270, 51402348, 51421002, 21173260, 11474333, 51372272, and 51627803), the Knowledge Innovation Program of the Chinese Academy of Sciences, the Natural Science Foundation of Beijing, China (Grant No. 4173077), USTB Talent Program, China (Grant No. 06500053), and Fundamental Research Funds for the Central Universities, China (Grant Nos. FRF-BR-16-018A, FRF-TP-17-069A1, and 06198178).

An inquiry-based approach to the Franck-Hertz experiment

NASA Astrophysics Data System (ADS)

Persano Adorno, Dominique; Pizzolato, Nicola

2016-05-01

The practice of scientists and engineers is today exerted within interdisciplinary contexts, placed at the intersections of different research fields, including nanoscale science. The development of the required competences is based on an effective science and engineering instruction, which should be able to drive the students towards a deeper understanding of quantum mechanics fundamental concepts and, at the same time, strengthen their reasoning skills and transversal abilities. In this study we report the results of an inquiry-driven learning path experienced by a sample of 12 electronic engineering undergraduates engaged to perform the Franck-Hertz experiment. Before being involved in this experimental activity, the students received a traditional lecture-based instruction on the fundamental concepts of quantum mechanics, but their answers to an open-ended questionnaire, administered at the beginning of the inquiry activity, demonstrated that the acquired knowledge was characterized by a strictly theoretical vision of quantum science, basically in terms of an artificial mathematical framework having very poor connections with the real world. The Franck Hertz experiment was introduced to the students by starting from the problem of finding an experimental confirmation of the Bohr's postulates asserting that atoms can absorb energy only in quantum portions. The whole activity has been videotaped and this allowed us to deeply analyse the student perception's change about the main concepts of quantum mechanics. We have found that the active participation to this learning experience favored the building of cognitive links among student theoretical perceptions of quantum mechanics and their vision of quantum phenomena, within an everyday context of knowledge. Furthermore, our findings confirm the benefits of integrating traditional lecture-based instruction on quantum mechanics with learning experiences driven by inquiry-based teaching strategies.

Structured simulation improves learning of the Fundamental Use of Surgical Energy™ curriculum: a multicenter randomized controlled trial.

PubMed

Madani, Amin; Watanabe, Yusuke; Townsend, Nicole; Pucher, Philip H; Robinson, Thomas N; Egerszegi, Patricia E; Olasky, Jaisa; Bachman, Sharon L; Park, Chan W; Amin, Nalin; Tang, David T; Haase, Erika; Bardana, Davide; Jones, Daniel B; Vassiliou, Melina; Fried, Gerald M; Feldman, Liane S

2016-02-01

Energy devices can result in devastating complications to patients. Yet, they remain poorly understood by trainees and surgeons. A single-institution pilot study suggested that structured simulation improves knowledge of the safe use of electrosurgery (ES) among trainees (Madani et al. in Surg Endosc 28(10):2772-2782, 2014). The purpose of this study was to estimate the extent to which the addition of this structured bench-top simulation improves ES knowledge across multiple surgical training programs. Trainees from 11 residency programs in Canada, the USA and UK participated in a 1-h didactic ES course, based on SAGES' Fundamental Use of Surgical Energy™ (FUSE) curriculum. They were then randomized to one of two groups: an unstructured hands-on session where trainees used ES devices (control group) or a goal-directed hands-on training session (Sim group). Pre- and post-curriculum (immediately and 3 months after) knowledge of the safe use of ES was assessed using separate examinations. Data are expressed as mean (SD) and N (%), *p < 0.05. A total of 289 (145 control; 144 Sim) trainees participated, with 186 (96 control; 90 Sim) completing the 3-month assessment. Baseline characteristics were similar between the two groups. Total score on the examination improved from 46% (10) to 84% (10)* for the entire cohort, with higher post-curriculum scores in the Sim group compared with controls [86% (9) vs. 83% (10)*]. All scores declined after 3 months, but remained higher in the Sim group [72% (18) vs. 64% (15)*]. Independent predictors of 3-month score included pre-curriculum score and participation in a goal-directed simulation. This multi-institutional study confirms that a 2-h curriculum based on the FUSE program improves surgical trainees' knowledge in the safe use of ES devices across training programs with various geographic locations and resident volumes. The addition of a structured interactive bench-top simulation component further improved learning.

Building the foundation to generate a fundamental care standardised data set.

PubMed

Jeffs, Lianne; Muntlin Athlin, Asa; Needleman, Jack; Jackson, Debra; Kitson, Alison

2018-06-01

This paper provides an overview of the current state of performance measurement, key trends and a methodological approach to leverage in efforts to generate a standardised data set for fundamental care. Considerable transformation is occurring in health care globally with organisations focusing on achieving the quadruple aim of improving the experience of care, the health of populations, and the experience of providing care while reducing per capita costs of health care. In response, healthcare organisations are employing performance measurement and quality improvement methods to achieve the quadruple aim. Despite the plethora of measures available to health managers, there is no standardised data set and virtually no indicators reflecting how patients actually experience the delivery of fundamental care, such as nutrition, hydration, mobility, respect, education and psychosocial support. Given the linkages of fundamental care to safety and quality metrics, efforts to build the evidence base and knowledge that captures the impact of enacting fundamental care across the healthcare continuum and lifespan should include generating a routinely collected data set of relevant measures. This paper provides an overview of the current state of performance measurement, key trends and a methodological approach to leverage in efforts to generate a standardised data set for fundamental care. Standardised data sets enable comparability of data across clinical populations, healthcare sectors, geographic locations and time and provide data about care to support clinical, administrative and health policy decision-making. © 2018 John Wiley & Sons Ltd.

Towards knowledge-based systems in clinical practice: development of an integrated clinical information and knowledge management support system.

PubMed

Kalogeropoulos, Dimitris A; Carson, Ewart R; Collinson, Paul O

2003-09-01

Given that clinicians presented with identical clinical information will act in different ways, there is a need to introduce into routine clinical practice methods and tools to support the scientific homogeneity and accountability of healthcare decisions and actions. The benefits expected from such action include an overall reduction in cost, improved quality of care, patient and public opinion satisfaction. Computer-based medical data processing has yielded methods and tools for managing the task away from the hospital management level and closer to the desired disease and patient management level. To this end, advanced applications of information and disease process modelling technologies have already demonstrated an ability to significantly augment clinical decision making as a by-product. The wide-spread acceptance of evidence-based medicine as the basis of cost-conscious and concurrently quality-wise accountable clinical practice suffices as evidence supporting this claim. Electronic libraries are one-step towards an online status of this key health-care delivery quality control environment. Nonetheless, to date, the underlying information and knowledge management technologies have failed to be integrated into any form of pragmatic or marketable online and real-time clinical decision making tool. One of the main obstacles that needs to be overcome is the development of systems that treat both information and knowledge as clinical objects with same modelling requirements. This paper describes the development of such a system in the form of an intelligent clinical information management system: a system which at the most fundamental level of clinical decision support facilitates both the organised acquisition of clinical information and knowledge and provides a test-bed for the development and evaluation of knowledge-based decision support functions.

[Food and nutrition knowledge of elementary and high school-age children from Chile's Metropolitan Region].

PubMed

Ivanovic, D; Castro, C G; Ivanovic, R

1996-09-01

In Chile there is scarce food and nutrition knowledge among school age children. To determine the degree of food and nutrition knowledge of elementary and high school children and its relationship to socioeconomic status, sex, type of school and geographic area. Between 1986 and 1987, a representative and proportional sample of 4509 children was chosen from the Metropolitan Region. This sample was stratified according to school grade, sex, type of school and geographical area. Graffar's modified method was used to measure socioeconomic status. Food and nutrition knowledge was assessed by a specific test for each grade, based on the objectives pursued by the curricular programs of the Ministry of Education. The test was applied to 4197 children. Food and nutrition knowledge was significantly lower in the second subcycle of elementary school, in males, in older children from each grade, in rural areas, in children of low socioeconomic status and in public schools. School age children were unaware of fundamental aspects related to food and nutrition and curriculum programs of the Ministry of Education should be reformulated to overcome these deficiencies.

[Knowledge of asthma: educational intervention with the 2014 GINA guide in primary care physicians].

PubMed

Pozo-Beltrán, César Fireth; Navarrete-Rodríguez, Elsy Maureen; Fernández-Soto, Roberto; Navarro-Munguía, Jazmín; Hall-Mondragón, Margareth Sharon; Sienra-Monge, Juan José; Del Río-Navarro, Blanca Estela

2016-01-01

Asthma is a public health problem in the world, so updating the guidelines for the diagnosis and treatment of asthma is based primarily on the practice of primary care physicians. Educational interventions are useful for increasing knowledge. To compare the level of knowledge of asthma before and after an educational intervention. A quasi-experimental prospective study was conducted in general and family practitioners and pediatricians who attended a training workshop on general aspects of asthma and current guidelines for diagnosis and treatment (GINA 2014). A questionnaire consisting of 11 multiple choice questions relating to fundamental aspects of the disease and diagnosis, classification, treatment and management of attacks, was used in two assessments, baseline and post-intervention. A total of 178 patients participated in the study, with knowledge pre-intervention at 25.5 points and post-intervention at 97.5 points on a scale of 100, with p < 0.05. Educational interventions are inexpensive and effective tools to increase the knowledge of health professionals, and they have an impact on improving patient care.

Group Theory with Applications in Chemical Physics

NASA Astrophysics Data System (ADS)

Jacobs, Patrick

2005-10-01

Group Theory is an indispensable mathematical tool in many branches of chemistry and physics. This book provides a self-contained and rigorous account on the fundamentals and applications of the subject to chemical physics, assuming no prior knowledge of group theory. The first half of the book focuses on elementary topics, such as molecular and crystal symmetry, whilst the latter half is more advanced in nature. Discussions on more complex material such as space groups, projective representations, magnetic crystals and spinor bases, often omitted from introductory texts, are expertly dealt with. With the inclusion of numerous exercises and worked examples, this book will appeal to advanced undergraduates and beginning graduate students studying physical sciences and is an ideal text for use on a two-semester course. An introductory and advanced text that comprehensively covers fundamentals and applications of group theory in detail Suitable for a two-semester course with numerous worked examples and problems Includes several topics often omitted from introductory texts, such as rotation group, space groups and spinor bases

Passed without a stroke: a UK mixed method study exploring student nurses' knowledge of stroke.

PubMed

Mason-Whitehead, Elizabeth; Ridgway, Victoria; Barton, Janet

2013-09-01

To evaluate third year student nurses' knowledge and experiences of stroke education. To identify how student nurses can develop their understanding of stroke and its application to clinical nursing practice. Stroke is an international health issue and a major cause of morbidity and mortality in many countries throughout the world. Nurses have a significant role to play in reducing death and disability in people who have suffered a stroke and it has been suggested that some nurses may not be educationally prepared to meet the challenges of this complex condition. This evaluative study was based on a mixed method evaluative design. These quantitative and qualitative approaches involved the implementation of focus groups and questionnaires. The following outcomes were measured during students' final year of their nursing studies: students' profiles and an assessment of students' knowledge of stroke. There was a mixed picture of student nurses' knowledge of stroke; a lack of awareness of some fundamental aspects of stroke including common symptoms, complications, risk factors and the long term treatment. Reassuringly, students expressed decisively the importance for nurses to be equipped with a sound foundation of stroke knowledge for clinical practice. All nursing students should have experience of being in contact with people who have had a stroke - and at present this does not always happen. A national intervention study is now suggested with a view to providing stroke education which is proportionate to its significance as a major health issue. Nurses draw upon their fundamental clinical skills to care and treat patients who have survived a stroke. Additionally, stroke survivors also require enhanced knowledge and this is recognised in the growth of specialist stroke nurses. Improving stroke mortality and morbidity is the responsibility of all of us involved in nurse education - introducing creative evaluative interventions could hold the most promising way forward. Copyright © 2012 Elsevier Ltd. All rights reserved.

Designing a training tool for imaging mental models

NASA Technical Reports Server (NTRS)

Dede, Christopher J.; Jayaram, Geetha

1990-01-01

The training process can be conceptualized as the student acquiring an evolutionary sequence of classification-problem solving mental models. For example a physician learns (1) classification systems for patient symptoms, diagnostic procedures, diseases, and therapeutic interventions and (2) interrelationships among these classifications (e.g., how to use diagnostic procedures to collect data about a patient's symptoms in order to identify the disease so that therapeutic measures can be taken. This project developed functional specifications for a computer-based tool, Mental Link, that allows the evaluative imaging of such mental models. The fundamental design approach underlying this representational medium is traversal of virtual cognition space. Typically intangible cognitive entities and links among them are visible as a three-dimensional web that represents a knowledge structure. The tool has a high degree of flexibility and customizability to allow extension to other types of uses, such a front-end to an intelligent tutoring system, knowledge base, hypermedia system, or semantic network.

The power of collaboration: using internet-based tools to facilitate networking and benchmarking within a consortium of academic health centers.

PubMed

Korner, Eli J; Oinonen, Michael J; Browne, Robert C

2003-02-01

The University HealthSystem Consortium (UHC) represents a strategic alliance of 169 academic health centers and associated institutions engaged in knowledge sharing and idea-generation. The use of the Internet as a tool in the delivery of UHC's products and services has increased dramatically over the past year and will continue to increase during the foreseeable future. This paper examines the current state of UHC-member institution driven tools and services that utilize the Web as a fundamental component in their delivery. The evolution of knowledge management at UHC, its management information and reporting tools, and expansion of e-commerce provide real world examples of Internet use in health care delivery and management. Health care workers are using these Web-based tools to help manage rising costs and optimize patient outcomes. Policy, technical, and organizational issues must be resolved to facilitate rapid adoption of Internet applications.

i-SAIRAS '90; Proceedings of the International Symposium on Artificial Intelligence, Robotics and Automation in Space, Kobe, Japan, Nov. 18-20, 1990

NASA Technical Reports Server (NTRS)

1990-01-01

The present conference on artificial intelligence (AI), robotics, and automation in space encompasses robot systems, lunar and planetary robots, advanced processing, expert systems, knowledge bases, issues of operation and management, manipulator control, and on-orbit service. Specific issues addressed include fundamental research in AI at NASA, the FTS dexterous telerobot, a target-capture experiment by a free-flying robot, the NASA Planetary Rover Program, the Katydid system for compiling KEE applications to Ada, and speech recognition for robots. Also addressed are a knowledge base for real-time diagnosis, a pilot-in-the-loop simulation of an orbital docking maneuver, intelligent perturbation algorithms for space scheduling optimization, a fuzzy control method for a space manipulator system, hyperredundant manipulator applications, robotic servicing of EOS instruments, and a summary of astronaut inputs on automation and robotics for the Space Station Freedom.

Extending emotion and decision-making beyond the laboratory: The promise of palliative care contexts.

PubMed

Ferrer, Rebecca A; Padgett, Lynne; Ellis, Erin M

2016-08-01

Although laboratory-based research on emotion and decision-making holds the distinct advantage of rigorous experimental control conditions that allow causal inferences, the question of how findings in a laboratory generalize to real-world settings remains. Identifying ecologically valid, real-world opportunities to extend laboratory findings is a valuable means of advancing this field. Palliative care-or care intended to provide relief from serious illness and aging-related complications during treatment or at the end of life-provides a particularly rich opportunity for such work. Here, we present an overview of palliative care, summarize existing research on emotion and palliative care decision-making, highlight challenges associated with conducting such research, outline examples of collaborative projects leveraging palliative care as a context for generating fundamental knowledge about emotion and decision-making, and describe the resources and collaborations necessary to conduct this type of research. In sum, palliative care holds unique promise as an emotionally laden context in which to answer fundamental questions about emotion and decision-making that extends our theoretical understanding of the role of emotion in high-stakes decision-making while simultaneously generating knowledge that can improve palliative care implementation. (PsycINFO Database Record (c) 2016 APA, all rights reserved).

The Combination of Just-in-Time Teaching and Wikispaces in Physics Classrooms

ERIC Educational Resources Information Center

Mohottala, Hashini E.

2013-01-01

The general student population enrolled in today's physics classrooms is diverse. They come from a variety of different educational backgrounds. Some demonstrate a good knowledge of natural laws of physics with a better understanding of mathematical concepts, while others show a fair knowledge in fundamentals of physics with a minimum knowledge in…

An Innovative Strategy for Teaching Health-Related Fitness Knowledge in Elementary Physical Education Classes

ERIC Educational Resources Information Center

Hodges, Michael

2015-01-01

For many decades, children and adolescents have had a deficient level of health-related fitness knowledge (HRFK). This is worrisome, since HRFK acquisition has been found to be fundamental for individuals' decision-making as it relates to healthy living. Consequently, Knowledge in Action (KIA) fitness was developed to offer elementary teachers an…

How to Write "How-to" Books with High School Ecology & Horticulture Students

ERIC Educational Resources Information Center

Merritt, Maya; Shajira, Natasya; Daisey, Peggy

2003-01-01

It is essential for students to think clearly about fundamental biological concepts. One of the benefits of writing is that it promotes and enhances thinking. If students can write clearly, they are thinking clearly. Writing helps to connect new knowledge with prior knowledge and promotes the construction of knowledge. Writing-to-learn activities…

Technical design and system implementation of region-line primitive association framework

NASA Astrophysics Data System (ADS)

Wang, Min; Xing, Jinjin; Wang, Jie; Lv, Guonian

2017-08-01

Apart from regions, image edge lines are an important information source, and they deserve more attention in object-based image analysis (OBIA) than they currently receive. In the region-line primitive association framework (RLPAF), we promote straight-edge lines as line primitives to achieve powerful OBIAs. Along with regions, straight lines become basic units for subsequent extraction and analysis of OBIA features. This study develops a new software system called remote-sensing knowledge finder (RSFinder) to implement RLPAF for engineering application purposes. This paper introduces the extended technical framework, a comprehensively designed feature set, key technology, and software implementation. To our knowledge, RSFinder is the world's first OBIA system based on two types of primitives, namely, regions and lines. It is fundamentally different from other well-known region-only-based OBIA systems, such as eCogntion and ENVI feature extraction module. This paper has important reference values for the development of similarly structured OBIA systems and line-involved extraction algorithms of remote sensing information.

Annual cycle of Scots pine photosynthesis

NASA Astrophysics Data System (ADS)

Hari, Pertti; Kerminen, Veli-Matti; Kulmala, Liisa; Kulmala, Markku; Noe, Steffen; Petäjä, Tuukka; Vanhatalo, Anni; Bäck, Jaana

2017-12-01

Photosynthesis, i.e. the assimilation of atmospheric carbon to organic molecules with the help of solar energy, is a fundamental and well-understood process. Here, we connect theoretically the fundamental concepts affecting C3 photosynthesis with the main environmental drivers (ambient temperature and solar light intensity), using six axioms based on physiological and physical knowledge, and yield straightforward and simple mathematical equations. The light and carbon reactions in photosynthesis are based on the coherent operation of the photosynthetic machinery, which is formed of a complicated chain of enzymes, membrane pumps and pigments. A powerful biochemical regulation system has emerged through evolution to match photosynthesis with the annual cycle of solar light and temperature. The action of the biochemical regulation system generates the annual cycle of photosynthesis and emergent properties, the state of the photosynthetic machinery and the efficiency of photosynthesis. The state and the efficiency of the photosynthetic machinery is dynamically changing due to biosynthesis and decomposition of the molecules. The mathematical analysis of the system, defined by the very fundamental concepts and axioms, resulted in exact predictions of the behaviour of daily and annual patterns in photosynthesis. We tested the predictions with extensive field measurements of Scots pine (Pinus sylvestris L.) photosynthesis on a branch scale in northern Finland. Our theory gained strong support through rigorous testing.

Characterization of the tunneling conductance across DNA bases

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zikic, Radomir; Krstic, Predrag S; Zhang, Xiaoguang

2006-01-01

Characterization of the electrical properties of the DNA bases, Adenine, Cytosine, Guanine and Thymine, besides building the basic knowledge on these fundamental constituents of a DNA, is a crucial step in developing a DNA sequencing technology. We present a first-principles study of the current-voltage characteristics of nucleotide-like molecules of the DNA bases, placed in a 1.5 nm gap formed between gold nanoelectrodes. The quantum transport calculations in the tunneling regime are shown to vary strongly with the electrode-molecule geometry and the choice of the DFT exchangecorrelation functionals. Analysis of the results in the zero-bias limit indicates that distinguishable current-voltage characteristicsmore » of different DNA bases are dominated by the geometrical conformations of the bases and nanoelectrodes.« less

Characterization of the tunneling conductance across DNA bases.

PubMed

Zikic, Radomir; Krstić, Predrag S; Zhang, X-G; Fuentes-Cabrera, Miguel; Wells, Jack; Zhao, Xiongce

2006-07-01

Characterization of the electrical properties of the DNA bases (adenine, cytosine, guanine, and thymine), in addition to building the basic knowledge on these fundamental constituents of a DNA, is a crucial step in developing a DNA sequencing technology. We present a first-principles study of the current-voltage characteristics of nucleotidelike molecules of the DNA bases, placed in a 1.5 nm gap formed between gold nanoelectrodes. The quantum transport calculations in the tunneling regime are shown to vary strongly with the electrode-molecule geometry and the choice of the density-functional theory exchange-correlation functionals. Analysis of the results in the zero-bias limit indicates that distinguishable current-voltage characteristics of different DNA bases are dominated by the geometrical conformations of the bases and nanoelectrodes.

VLT/ISAAC images of quasar hosts at z = 1.5

NASA Astrophysics Data System (ADS)

Falomo, R.; Kotilainen, J.; Treves, A.

2000-09-01

Our present knowledge of quasar host galaxies is essentially limited to z < 1. Fundamental data come specifically from observations obtained using both Hubble Space Telescope (HST, e.g. Disney et al. 1995; Bahcall et al. 1997; Boyce et al. 1998; McLure et al. 1999) and ground-based 4-m-class telescopes (e.g. McLeod & Rieke 1994, 1995; Taylor et al. 1996; Kotilainen, Falomo & Scarpa 1998; Hutchings et al. 1999; Kotilainen & Falomo 2000; Percival et al. 2000).

Continuous-wave laser at 440 nm based on frequency-doubled diode-pumped Nd:GdVO(4) crystal.

PubMed

Castaing, Marc; Balembois, François; Georges, Patrick

2008-09-01

We present for the first time, to the best of our knowledge, a frequency-doubled Nd:GdVO(4) laser operating in a cw on the pure three-level laser line at 880 nm. We obtained 300 mW at 440 nm for 23 W of incident pump power at 808 nm. Moreover, with a 25% output coupler we obtained a cw power of 1.9 W at the fundamental wavelength at 880 nm.

Reconstruction of Pedagogical Education--The Fundamental and the Applied in Teacher Education

ERIC Educational Resources Information Center

Asadullin, Rail Mirvaevich; Teregulov, Filarit Sharifovich

2015-01-01

Authors propose a new approach for the development of educational sphere, where philosophical categories of fundamental and applied knowledge are considered as two counter processes of reality and pole cognition, between which project-technological activity is carried out. This fact allows to treat any pedagogical project as a compromise decision,…

Al-Faruqi's Fundamental Ideas and Philosophy of Education

ERIC Educational Resources Information Center

Rahman, Tasnim Abdul; Yusof, Wan Sabri Wan; Rashid, Zuriati Mohd; Amir, Ahmad Nabil

2015-01-01

This paper discusses the fundamental ideal and philosophy of education advocated by Ismail Raji al-Faruqi (1921-1986) in realizing the Islamization of knowledge (IOK) project. The concept and perspective of education projected by al-Faruqi was constructed on the worldview of tawhid that reflected the essence and intrinsic philosophy and paradigm…

14 CFR 121.911 - Indoctrination curriculum.

Code of Federal Regulations, 2013 CFR

2013-01-01

... knowledge appropriate to the duty position. (c) For instructors: The fundamental principles of the teaching and learning process; methods and theories of instruction; and the knowledge necessary to use aircraft... curriculums, as appropriate. (d) For evaluators: General evaluation requirements of the AQP; methods of...

14 CFR 121.911 - Indoctrination curriculum.

Code of Federal Regulations, 2014 CFR

2014-01-01

... knowledge appropriate to the duty position. (c) For instructors: The fundamental principles of the teaching and learning process; methods and theories of instruction; and the knowledge necessary to use aircraft... curriculums, as appropriate. (d) For evaluators: General evaluation requirements of the AQP; methods of...

14 CFR 121.911 - Indoctrination curriculum.

Code of Federal Regulations, 2012 CFR

2012-01-01

... knowledge appropriate to the duty position. (c) For instructors: The fundamental principles of the teaching and learning process; methods and theories of instruction; and the knowledge necessary to use aircraft... curriculums, as appropriate. (d) For evaluators: General evaluation requirements of the AQP; methods of...

225-255-GHz InP DHBT Frequency Tripler MMIC Using Complementary Split-Ring Resonator

NASA Astrophysics Data System (ADS)

Li, Xiao; Zhang, Yong; Li, Oupeng; Sun, Yan; Lu, Haiyan; Cheng, Wei; Xu, Ruimin

2017-02-01

In this paper, a novel design of frequency tripler monolithic microwave integrated circuit (MMIC) using complementary split-ring resonator (CSRR) is proposed based on 0.5-μm InP DHBT process. The CSRR-loaded microstrip structure is integrated in the tripler as a part of impedance matching network to suppress the fundamental harmonic, and another frequency tripler based on conventional band-pass filter is presented for comparison. The frequency tripler based on CSRR-loaded microstrip generates an output power between -8 and -4 dBm from 228 to 255 GHz when the input power is 6 dBm. The suppression of fundamental harmonic is better than 20 dBc at 77-82 GHz input frequency within only 0.15 × 0.15 mm2 chip area of the CSRR structure on the ground layer. Compared with the frequency tripler based on band-pass filter, the tripler using CSRR-loaded microstrip obtains a similar suppression level of unwanted harmonics and higher conversion gain within a much smaller chip area. To our best knowledge, it is the first time that CSRR is used for harmonic suppression of frequency multiplier at such high frequency band.

Design and Development of a Sharable Clinical Decision Support System Based on a Semantic Web Service Framework.

PubMed

Zhang, Yi-Fan; Gou, Ling; Tian, Yu; Li, Tian-Chang; Zhang, Mao; Li, Jing-Song

2016-05-01

Clinical decision support (CDS) systems provide clinicians and other health care stakeholders with patient-specific assessments or recommendations to aid in the clinical decision-making process. Despite their demonstrated potential for improving health care quality, the widespread availability of CDS systems has been limited mainly by the difficulty and cost of sharing CDS knowledge among heterogeneous healthcare information systems. The purpose of this study was to design and develop a sharable clinical decision support (S-CDS) system that meets this challenge. The fundamental knowledge base consists of independent and reusable knowledge modules (KMs) to meet core CDS needs, wherein each KM is semantically well defined based on the standard information model, terminologies, and representation formalisms. A semantic web service framework was developed to identify, access, and leverage these KMs across diverse CDS applications and care settings. The S-CDS system has been validated in two distinct client CDS applications. Model-level evaluation results confirmed coherent knowledge representation. Application-level evaluation results reached an overall accuracy of 98.66 % and a completeness of 96.98 %. The evaluation results demonstrated the technical feasibility and application prospect of our approach. Compared with other CDS engineering efforts, our approach facilitates system development and implementation and improves system maintainability, scalability and efficiency, which contribute to the widespread adoption of effective CDS within the healthcare domain.

Knowing and Learning Mathematics for Teaching: Proceedings of a Workshop (March 19-21, 1999).

ERIC Educational Resources Information Center

National Academy of Sciences - National Research Council, Washington, DC. Mathematical Sciences Education Board.

The Mathematics Teacher Preparation Content Workshop, held March 19-21, 1999, focused on two questions: (1) What is the mathematical knowledge teachers need to know in order to teach well? and (2) How can teachers develop the mathematical knowledge they need to teach well? Chapters include: (1) "Knowledge of Fundamental Mathematics for Teaching"…

Knowledge-based design of a biosensor to quantify localized ERK activation in living cells

PubMed Central

Kummer, Lutz; Hsu, Chia-Wen; Dagliyan, Onur; MacNevin, Christopher; Kaufholz, Melanie; Zimmermann, Bastian; Dokholyan, Nikolay V.; Hahn, Klaus M.; Plückthun, Andreas

2014-01-01

Summary Investigation of protein activation in living cells is fundamental to understand how proteins are influenced by the full complement of upstream regulators they experience. We describe here the generation of a biosensor based on the Designed Ankyrin Repeat Protein (DARPin) binding scaffold suited for intracellular applications. Combining selection and evolution from libraries, knowledge-based design and efficient and rapid testing of conjugate candidates, we created an ERK activity biosensor by derivatizing a DARPin specific for phosphorylated ERK (pERK) with a solvatochromic merocyanine dye (mero87), whose fluorescence increases upon pERK binding. The biosensor specifically responded to pERK2, recognized by its conformation, but not to non-phosphorylated ERK2 or other closely related mitogen-activated kinases tested. Activated endogenous ERK was visualized in mouse embryo fibroblasts incubated in 2% serum, revealing greater activation in the nucleus, perinuclear regions, and especially the nucleoli. Activity was greatly reduced by the MEK1/2 inhibitor U0126. The DARPin-based biosensor will serve as useful tool for studying biological functions of ERK in vitro and in vivo. PMID:23790495

Paper-based sensors and assays: a success of the engineering design and the convergence of knowledge areas.

PubMed

López-Marzo, Adaris M; Merkoçi, Arben

2016-08-16

This review shows the recent advances and state of the art in paper-based analytical devices (PADs) through the analysis of their integration with microfluidics and LOC micro- and nanotechnologies, electrochemical/optical detection and electronic devices as the convergence of various knowledge areas. The important role of the paper design/architecture in the improvement of the performance of sensor devices is discussed. The discussion is fundamentally based on μPADs as the new generation of paper-based (bio)sensors. Data about the scientific publication ranking of PADs, illustrating their increase as an experimental research topic in the past years, are supplied. In addition, an analysis of the simultaneous evolution of PADs in academic lab research and industrial commercialization highlighting the parallelism of the technological transfer from academia to industry is displayed. A general overview of the market behaviour, the leading industries in the sector and their commercialized devices is given. Finally, personal opinions of the authors about future perspectives and tendencies in the design and fabrication technology of PADs are disclosed.

Integration of language and sensor information

NASA Astrophysics Data System (ADS)

Perlovsky, Leonid I.; Weijers, Bertus

2003-04-01

The talk describes the development of basic technologies of intelligent systems fusing data from multiple domains and leading to automated computational techniques for understanding data contents. Understanding involves inferring appropriate decisions and recommending proper actions, which in turn requires fusion of data and knowledge about objects, situations, and actions. Data might include sensory data, verbal reports, intelligence intercepts, or public records, whereas knowledge ought to encompass the whole range of objects, situations, people and their behavior, and knowledge of languages. In the past, a fundamental difficulty in combining knowledge with data was the combinatorial complexity of computations, too many combinations of data and knowledge pieces had to be evaluated. Recent progress in understanding of natural intelligent systems, including the human mind, leads to the development of neurophysiologically motivated architectures for solving these challenging problems, in particular the role of emotional neural signals in overcoming combinatorial complexity of old logic-based approaches. Whereas past approaches based on logic tended to identify logic with language and thinking, recent studies in cognitive linguistics have led to appreciation of more complicated nature of linguistic models. Little is known about the details of the brain mechanisms integrating language and thinking. Understanding and fusion of linguistic information with sensory data represent a novel challenging aspect of the development of integrated fusion systems. The presentation will describe a non-combinatorial approach to this problem and outline techniques that can be used for fusing diverse and uncertain knowledge with sensory and linguistic data.

A discourse on the nature of dental hygiene knowledge and knowing.

PubMed

Cobban, S J; Edgington, E M; Myrick, F; Keenan, L

2009-02-01

Historically, dental hygiene has adopted theory and research from other health disciplines, without adequately modifying these concepts to reflect the unique dental hygiene practice context, leaving dental hygiene's research and theory base underdeveloped. Dental hygiene has yet to articulate its epistemological assumptions--the nature, scope and object of dental hygiene knowledge--or to fully describe the patterns of knowing that are brought to practice. This paper uses a method of inquiry from philosophy to begin the discourse about dental hygiene ways of knowing. In nursing, Carper identified four fundamental patterns of knowing: empirics or the science of nursing; aesthetics or the art of nursing; personal knowledge and ethical or moral knowledge. These patterns were used to explore this concept within dental hygiene. There is more to the nature of dental hygiene knowledge and knowing than rote application of technique-related or research-based information in practice, including judgements about when and how to use different types of information that are used. Currently, empirical forms of knowledge seem to be disproportionately valued, yet evidence was found for all of Carper's four patterns of knowing. Carper's work on patterns of knowing in nursing provided a useful framework to initiate the discourse on ways of knowing in dental hygiene. These results are submitted for others to challenge, refine and extend, for continuing the discussion. Dental hygiene leaders and scholars need to engage in discourse about extending the epistemological assumptions to reflect reality.

Apes have culture but may not know that they do

PubMed Central

Gruber, Thibaud; Zuberbühler, Klaus; Clément, Fabrice; van Schaik, Carel

2015-01-01

There is good evidence that some ape behaviors can be transmitted socially and that this can lead to group-specific traditions. However, many consider animal traditions, including those in great apes, to be fundamentally different from human cultures, largely because of lack of evidence for cumulative processes and normative conformity, but perhaps also because current research on ape culture is usually restricted to behavioral comparisons. Here, we propose to analyze ape culture not only at the surface behavioral level but also at the underlying cognitive level. To this end, we integrate empirical findings in apes with theoretical frameworks developed in developmental psychology regarding the representation of tools and the development of metarepresentational abilities, to characterize the differences between ape and human cultures at the cognitive level. Current data are consistent with the notion of apes possessing mental representations of tools that can be accessed through re-representations: apes may reorganize their knowledge of tools in the form of categories or functional schemes. However, we find no evidence for metarepresentations of cultural knowledge: apes may not understand that they or others hold beliefs about their cultures. The resulting Jourdain Hypothesis, based on Molière’s character, argues that apes express their cultures without knowing that they are cultural beings because of cognitive limitations in their ability to represent knowledge, a determining feature of modern human cultures, allowing representing and modifying the current norms of the group. Differences in metarepresentational processes may thus explain fundamental differences between human and other animals’ cultures, notably limitations in cumulative behavior and normative conformity. Future empirical work should focus on how animals mentally represent their cultural knowledge to conclusively determine the ways by which humans are unique in their cultural behavior. PMID:25705199

Sources, topics and use of knowledge by coaches.

PubMed

Stoszkowski, John; Collins, Dave

2016-01-01

In recent years, the value of social learning approaches as part of the design and delivery of formalised coach development initiatives has gained credence in the literature. However, insight is currently lacking into the fundamental social dimensions that underpin coach learning. Accordingly, this study aimed to explore coaches' perceptions of their actual and preferred methods of acquiring new coaching knowledge, the types of knowledge they currently acquire and/or desire, and their application of new knowledge. Responses to an online survey, completed by practicing coaches (N = 320) in a range of sports and contexts, were analysed descriptively and inductively. Results revealed that coaches preferred, and mostly acquired, coaching knowledge from informal learning activities, especially when these permitted social interaction. Notably, however, formal coach education courses were also reported relatively frequently as a source of recent knowledge acquisition. Nevertheless, critical justification for and application of acquired knowledge was largely absent. Based on the findings, we suggest that, before social learning activities such as mentoring schemes and communities of practice are placed at the centre of formalised coach development provision, coach educators must put in place the support structures to better enable coaches to recognise and deal with the potentially mixed influences of the social milieu on coach learning, aiming to ensure that their informal development is sufficiently open-minded, reflective and critical.

Influence of a Physical Education Methods Course on Elementary Education Majors' Knowledge of Fundamental Movement Skills

ERIC Educational Resources Information Center

Hart, Melanie A.

2005-01-01

With an increase concern for childhood obesity, many individuals and organizations are emphasizing the importance of quality physical education. The need for quality physical education at the elementary level is extremely important as research has shown a relationship between the performance of fundamental movement skills and children's body…

The Use of Therapeutic Techniques in Actor Training.

ERIC Educational Resources Information Center

Gross, Roger

Since a fundamental problem of acting--fear--is a fundamental human problem, the basic job of acting teachers is to help their students become the kind of people who can act. Acting teachers need to help their students cast off their fears, free their bodies and their imaginations, and learn all the skills of self-knowledge, self-control, and…

Education of Women in Islam: A Critical Islamic Interpretation of the Quran

ERIC Educational Resources Information Center

Abukari, Abdulai

2014-01-01

In Islam, knowledge, its acquisition and application is a fundamental requirement for all Muslims to enable them to believe, think, and act according to the principles of the religion. However, differences in style of interpretation of the Qur'an have led to text being interpreted against its own fundamental worldview; an example is the…

Managing Knowledge through "Hoshin Kanri"

ERIC Educational Resources Information Center

Tennant C.; Roberts P.

2003-01-01

A fundamental challenge within business organizations (whether manufacturing or service, large or small) is posed by the difficulties associated with managing knowledge to integrate the long-term vision and strategic goals with daily working processes and with people. The traditional Western approach of "Management by Objectives" (MbO)…

An early history of T cell-mediated cytotoxicity.

PubMed

Golstein, Pierre; Griffiths, Gillian M

2018-04-16

After 60 years of intense fundamental research into T cell-mediated cytotoxicity, we have gained a detailed knowledge of the cells involved, specific recognition mechanisms and post-recognition perforin-granzyme-based and FAS-based molecular mechanisms. What could not be anticipated at the outset was how discovery of the mechanisms regulating the activation and function of cytotoxic T cells would lead to new developments in cancer immunotherapy. Given the profound recent interest in therapeutic manipulation of cytotoxic T cell responses, it is an opportune time to look back on the early history of the field. This Timeline describes how the early findings occurred and eventually led to current therapeutic applications.

COM3/369: Knowledge-based Information Systems: A new approach for the representation and retrieval of medical information

PubMed Central

Mann, G; Birkmann, C; Schmidt, T; Schaeffler, V

1999-01-01

Introduction Present solutions for the representation and retrieval of medical information from online sources are not very satisfying. Either the retrieval process lacks of precision and completeness the representation does not support the update and maintenance of the represented information. Most efforts are currently put into improving the combination of search engines and HTML based documents. However, due to the current shortcomings of methods for natural language understanding there are clear limitations to this approach. Furthermore, this approach does not solve the maintenance problem. At least medical information exceeding a certain complexity seems to afford approaches that rely on structured knowledge representation and corresponding retrieval mechanisms. Methods Knowledge-based information systems are based on the following fundamental ideas. The representation of information is based on ontologies that define the structure of the domain's concepts and their relations. Views on domain models are defined and represented as retrieval schemata. Retrieval schemata can be interpreted as canonical query types focussing on specific aspects of the provided information (e.g. diagnosis or therapy centred views). Based on these retrieval schemata it can be decided which parts of the information in the domain model must be represented explicitly and formalised to support the retrieval process. As representation language propositional logic is used. All other information can be represented in a structured but informal way using text, images etc. Layout schemata are used to assign layout information to retrieved domain concepts. Depending on the target environment HTML or XML can be used. Results Based on this approach two knowledge-based information systems have been developed. The 'Ophthalmologic Knowledge-based Information System for Diabetic Retinopathy' (OKIS-DR) provides information on diagnoses, findings, examinations, guidelines, and reference images related to diabetic retinopathy. OKIS-DR uses combinations of findings to specify the information that must be retrieved. The second system focuses on nutrition related allergies and intolerances. Information on allergies and intolerances of a patient are used to retrieve general information on the specified combination of allergies and intolerances. As a special feature the system generates tables showing food types and products that are tolerated or not tolerated by patients. Evaluation by external experts and user groups showed that the described approach of knowledge-based information systems increases the precision and completeness of knowledge retrieval. Due to the structured and non-redundant representation of information the maintenance and update of the information can be simplified. Both systems are available as WWW based online knowledge bases and CD-ROMs (cf. http://mta.gsf.de topic: products).

Collecting Information for Rating Global Assessment of Functioning (GAF): Sources of Information and Methods for Information Collection.

PubMed

I H, Monrad Aas

2014-11-01

Global Assessment of Functioning (GAF) is an assessment instrument that is known worldwide. It is widely used for rating the severity of illness. Results from evaluations in psychiatry should characterize the patients. Rating of GAF is based on collected information. The aim of the study is to identify the factors involved in collecting information that is relevant for rating GAF, and gaps in knowledge where it is likely that further development would play a role for improved scoring. A literature search was conducted with a combination of thorough hand search and search in the bibliographic databases PubMed, PsycINFO, Google Scholar, and Campbell Collaboration Library of Systematic Reviews. Collection of information for rating GAF depends on two fundamental factors: the sources of information and the methods for information collection. Sources of information are patients, informants, health personnel, medical records, letters of referral and police records about violence and substance abuse. Methods for information collection include the many different types of interview - unstructured, semi-structured, structured, interviews for Axis I and II disorders, semistructured interviews for rating GAF, and interviews of informants - as well as instruments for rating symptoms and functioning, and observation. The different sources of information, and methods for collection, frequently result in inconsistencies in the information collected. The variation in collected information, and lack of a generally accepted algorithm for combining collected information, is likely to be important for rated GAF values, but there is a fundamental lack of knowledge about the degree of importance. Research to improve GAF has not reached a high level. Rated GAF values are likely to be influenced by both the sources of information used and the methods employed for information collection, but the lack of research-based information about these influences is fundamental. Further development of GAF is feasible and proposals for this are presented.

Developing a Peer Mentorship Program to Increase Competence in Clinical Supervision in Clinical Psychology Doctoral Training Programs.

PubMed

Foxwell, Aleksandra A; Kennard, Beth D; Rodgers, Cynthia; Wolfe, Kristin L; Cassedy, Hannah F; Thomas, Anna

2017-12-01

Supervision has recently been recognized as a core competency for clinical psychologists. This recognition of supervision as a distinct competency has evolved in the context of an overall focus on competency-based education and training in health service psychology, and has recently gained momentum. Few clinical psychology doctoral programs offer formal training experiences in providing supervision. A pilot peer mentorship program (PMP) where graduate students were trained in the knowledge and practice of supervision was developed. The focus of the PMP was to develop basic supervision skills in advanced clinical psychology graduate students, as well as to train junior doctoral students in fundamental clinical and practical skills. Advanced doctoral students were matched to junior doctoral students to gain experience in and increase knowledge base in best practices of supervision skills. The 9-month program consisted of monthly mentorship meetings and three training sessions. The results suggested that mentors reported a 30% or more shift from the category of not competent to needs improvement or competent, in the following supervision competencies: theories of supervision, improved skill in supervision modalities, acquired knowledge in supervision, and supervision experience. Furthermore, 50% of the mentors reported that they were not competent in supervision experience at baseline and only 10% reported that they were not competent at the end of the program. Satisfaction data suggested that satisfaction with the program was high, with 75% of participants indicating increased knowledge base in supervision, and 90% indicating that it was a positive addition to their training program. This program was feasible and acceptable and appears to have had a positive impact on the graduate students who participated. Students reported both high satisfaction with the program as well as an increase in knowledge base and experience in supervision skills.

Effect of mergers and acquisitions on drug discovery: perspective from a case study of a Japanese pharmaceutical company.

PubMed

Shibayama, Sotaro; Tanikawa, Kunihiro; Fujimoto, Ryuhei; Kimura, Hiromichi

2008-01-01

The pharmaceutical industry has experienced intermittent waves of mergers and acquisitions (M&As) since the 1980s and recently appeared to be in yet another wave. Previous studies indicated rather negative impacts of consolidation on research and development, suggesting that they do not necessarily lead to long-term reinforcement of research capabilities, although they may enrich the drug pipeline in the short term. However, recent studies have implied a positive side in terms of knowledge-base transfer. Further micro-organizational studies suggested that scientists learned new knowledge and approaches from partner scientists and improved their performance and innovation. These findings imply that measures for the scientist-level integration after M&As would reinforce fundamental research capabilities in the long term.

Comparing and contrasting knowledge of pressure ulcer assessment, prevention and management in people with spinal cord injury among nursing staff working in two metropolitan spinal units and rehabilitation medicine training specialists in a three-way comparison.

PubMed

Gupta, N; Loong, B; Leong, G

2012-02-01

To assess for differences in knowledge of pressure ulcer (PU) prevention and management among nurses working in two metropolitan spinal cord injury (SCI) units, and between nurses and rehabilitation registrars (doctors). There is anecdotal evidence of wide variation in PU management. An understanding of current knowledge is fundamental to evidence-based practice implementation. This was a prospective survey, using a multiple choice question format developed with nurse wound specialists. A total of 10 questions assessed PU prevention and 10 assessed management. It was distributed to nurses working at the spinal units and rehabilitation registrars. The results from the groups were analysed for similarities and differences using one- and two-way analysis of variance (ANOVA) tests and tests for significance of specific linear combinations of group means. The response rate was 79% (19/24) and 71% (20/ 28) from the two SCI units, and 46% (13/28) from doctors. Doctors performed better than nurses on prevention questions (P<0.005) but worse on management (P<0.05). There was a significant difference in management knowledge (P<0.001) between nurses working in the two units but not in prevention knowledge (P<0.5) and interestingly years of experience did not correlate with performance (P<0.2 for prevention and P<0.5 for management questions). Rehabilitation registrars score better in prevention questions, but poorer in management questions, which reflects academic rather than experiential knowledge. There are also differences in management knowledge among nurses, based on work area rather than years of experience. Although knowledge does not necessarily reflect practice, this calls for better standardisation and implementation of wound management pathways.

Research and Teaching: Analyzing Upper Level Undergraduate Knowledge of Evolutionary Processes-- Can Class Discussions Help?

ERIC Educational Resources Information Center

Tran, Mark V.; Weigel, Emily G.; Richmond, Gail

2014-01-01

For biologists, a proper understanding of evolutionary processes is fundamentally important. However, undergraduate biology students often struggle to understand evolutionary processes, replacing factual knowledge with misconceptions on the subject. Classroom discussions can be effective active learning tools used to address these misconceptions…

National Security Management Correspondence Course.

ERIC Educational Resources Information Center

Industrial Coll. of the Armed Forces (DOD), Washington, DC.

A course of study on the fundamental aspects of the areas of knowledge which are essential to effective management of national security is presented. The course presents the substance of the Industrial College resident curriculum adapted to the correspondence method of study. The subject matter is designed to impart knowledge and understanding of…

Undergraduate Professors' Pedagogical Content Knowledge: The Case of "Amount of Substance"

ERIC Educational Resources Information Center

Padilla, Kira; Ponce-de-Leon, Ana Maria; Rembado, Florencia Mabel; Garritz, Andoni

2008-01-01

This paper documents the pedagogical content knowledge (PCK) of four university professors in General Chemistry for the topic "amount of substance"; a fundamental quantity of the International System of Units (SI). The research method involved the development of a Content Representation and the application of Mortimer's Conceptual…

Transformational Leadership and Knowledge Sharing: Mediating Roles of Employee's Empowerment, Commitment, and Citizenship Behaviors

ERIC Educational Resources Information Center

Han, Seung Hyun; Seo, Gaeun; Yoon, Seung Won; Yoon, Dong-Yeol

2016-01-01

Purpose: The purpose of this paper is to empirically examine the fundamental process through which transformational leaders play a significant role in employees' knowledge sharing by investigating mediating roles of individual affects, particularly psychological empowerment, organizational commitment and organizational citizenship behavior (OCB).…

Contrasting Knowledge for Elementary and Secondary Mathematics Teaching

ERIC Educational Resources Information Center

Rowland, Tim

2012-01-01

This paper describes and analyses two mathematics lessons, one with very young pupils, about subtraction, the other for lower secondary school pupils, about gradients [slopes] and graphs. The focus of the analysis is on teacher knowledge, and on the fundamental mathematical and mathematics-pedagogical prerequisites that underpin teaching these…

Hybrid regimes of knowledge? Challenges for constructing scientific evidence in the context of the GMO-debate.

PubMed

Böschen, Stefan

2009-07-01

Over the last two decades, there has been a remarkable shift of attention to the scientific and political fundamentals of the precautionary principle. The application of this principle has become a main strategy of coping with the different forms and problems related to non-knowledge. Thus, societies are increasingly confronted with the challenging and hitherto unresolved problem of political and technological decision-making under conditions of diverging framings of non-knowledge. At present, there seems to be no generally accepted scientific or institutional approach. This is why the fundamental question of how different scientific actors define and construct evidence is not answered yet. Hence, this paper is based on the consideration that the conflicts in risk policy concerning genetically modified organisms (GMO) depend on the unresolved conflicts about the diverging scientific strategies and structures of evidence-making between the epistemic cultures involved. Thus, this study investigates two questions: (1) do the epistemic strategies of evidence-making differ systematically with the scientific actors involved in the GMO-debate? (2) What consequences emerge considering institutionalized procedures of decision-making? This article is based on a secondary analysis of findings and perspectives reported in the literature and on the methods of qualitative social empirical research, i.e., interviews with experts. A total number of 34 interviews were conducted to explore the different strategies of handling non-knowledge and constructing evidence. Actors from science, administration, business and NGOs were interviewed. In this way, typical epistemic cultures can be described. An epistemic culture is the constellation of methodological strategies, theoretical assumptions and practical-experimental settings which define in every speciality the ways how we know what we know. There are two main results. Firstly, it was worked out that the epistemic cultures involved in the GMO-debate use rather distinct strategies to define non-knowledge and to classify evidence. There are three types of constructing evidence, which correspond to different types of epistemic cultures. Secondly, the findings imply that the intensity of the conflicts in risk policy fields like the GMO-debate is due to a lack of knowledge politics. Usually, knowledge politics is restricted to the design of institutional procedures to compile knowledge provided by experts. The institutional setting of risk analysis and risk management is based on the premise of strict separation between knowledge and power. However, inadmissible mixing-up of knowledge and power is observable. It seems that non-knowledge leads to an epistemic no man's land, and, hence, hybrid regimes of knowledge emerge. These regimes are hybrid with respect to the unclear and not explicitly reflected strategies of evidence-making. By lacking of knowledge politics, this situation opens up 'windows of opportunity' for actors with special interests in risk policy fields like the GMO-debate. Therefore, there is a difference between the visible institutionalized structures of risk policies and the rather invisible hybrid regimes of knowledge. Structure and scope of expertise have to be reflected and new instruments of knowledge politics have to be designed. Different epistemic cultures can be qualified by describing their particular strategies of evidence-making. To solve the conflicts between these strategies, a meta-expertise is needed. Besides the institutionalized settings of knowledge politics, the underlying hybrid regimes of knowledge have to be identified. The concept of epistemic cultures and their strategies of evidence-making should be investigated more explicitly with respect to other risk policy fields The analysis of hybrid regimes of knowledge should be deepened by looking at the complex interactions between institutional, discursive and practical rules affecting risk assessment.

Soft Robotics: New Perspectives for Robot Bodyware and Control

PubMed Central

Laschi, Cecilia; Cianchetti, Matteo

2014-01-01

The remarkable advances of robotics in the last 50 years, which represent an incredible wealth of knowledge, are based on the fundamental assumption that robots are chains of rigid links. The use of soft materials in robotics, driven not only by new scientific paradigms (biomimetics, morphological computation, and others), but also by many applications (biomedical, service, rescue robots, and many more), is going to overcome these basic assumptions and makes the well-known theories and techniques poorly applicable, opening new perspectives for robot design and control. The current examples of soft robots represent a variety of solutions for actuation and control. Though very first steps, they have the potential for a radical technological change. Soft robotics is not just a new direction of technological development, but a novel approach to robotics, unhinging its fundamentals, with the potential to produce a new generation of robots, in the support of humans in our natural environments. PMID:25022259

Imaging of Hereditary Hemorrhagic Telangiectasia

DOE Office of Scientific and Technical Information (OSTI.GOV)

Carette, Marie-France, E-mail: marie-france.carette@tnn.aphp.fr; Nedelcu, Cosmina; Tassart, Marc

This pictorial review is based on our experience of the follow-up of 120 patients at our multidisciplinary center for hereditary hemorrhagic telangiectasia (HHT). Rendu-Osler-Weber disease or HHT is a multiorgan autosomal dominant disorder with high penetrance, characterized by epistaxis, mucocutaneous telangiectasis, and visceral arteriovenous malformations (AVMs). The research on gene mutations is fundamental and family screening by clinical examination, chest X-ray, research of pulmonary shunting, and abdominal color Doppler sonography is absolutely necessary. The angioarchitecture of pulmonary AVMs can be studied by unenhanced multidetector computed tomography; however, all other explorations of liver, digestive bowels, or brain require administration of contrastmore » media. Magnetic resonance angiography is helpful for central nervous system screening, in particular for the spinal cord, but also for pulmonary, hepatic, and pelvic AVMs. Knowledge of the multiorgan involvement of HHT, mechanism of complications, and radiologic findings is fundamental for the correct management of these patients.« less

[Neurological sciences based on evidence].

PubMed

Ceballos, C; Almárcegui, C; Artal, A; García-Campayo, J; Valdizán, J R

An exhaustive search of reported metanalysis from any medical speciality is described. Search of papers included in MEDLINE or EMBASE between 1973-1998. A descriptive analysis of the reported papers (frequency tables and graphics) is described, including differences of mean of reported metanalysis papers by medical speciality and year. 1,514 papers were selected and classified. Between 1977-1987 overall mean of reported studies of neurologic metanalysis (1.20 +/- 1.10) was significatively inferior to the 1988-1998 (11.20 +/- 7.85) (p < 0.001). Global number of neurologic metanalysis was positively correlated (p < 0.05) with the number of studies about fundamentals and methodology during the study period. A progressive increase in the number of reported neurologic metanalysis since 1977 can be demonstrated. Diffusion of knowledge about fundamentals and methodology of metanalysis seems to have drawn and increase in performing and reporting this kind of analysis.

Research using qualitative, quantitative or mixed methods and choice based on the research.

PubMed

McCusker, K; Gunaydin, S

2015-10-01

Research is fundamental to the advancement of medicine and critical to identifying the most optimal therapies unique to particular societies. This is easily observed through the dynamics associated with pharmacology, surgical technique and the medical equipment used today versus short years ago. Advancements in knowledge synthesis and reporting guidelines enhance the quality, scope and applicability of results; thus, improving health science and clinical practice and advancing health policy. While advancements are critical to the progression of optimal health care, the high cost associated with these endeavors cannot be ignored. Research fundamentally needs to be evaluated to identify the most efficient methods of evaluation. The primary objective of this paper is to look at a specific research methodology when applied to the area of clinical research, especially extracorporeal circulation and its prognosis for the future. © The Author(s) 2014.

Hydrology

NASA Astrophysics Data System (ADS)

Brutsaert, Wilfried

2005-08-01

Water in its different forms has always been a source of wonder, curiosity and practical concern for humans everywhere. Hydrology - An Introduction presents a coherent introduction to the fundamental principles of hydrology, based on the course that Wilfried Brutsaert has taught at Cornell University for the last thirty years. Hydrologic phenomena are dealt with at spatial and temporal scales at which they occur in nature. The physics and mathematics necessary to describe these phenomena are introduced and developed, and readers will require a working knowledge of calculus and basic fluid mechanics. The book will be invaluable as a textbook for entry-level courses in hydrology directed at advanced seniors and graduate students in physical science and engineering. In addition, the book will be more broadly of interest to professional scientists and engineers in hydrology, environmental science, meteorology, agronomy, geology, climatology, oceanology, glaciology and other earth sciences. Emphasis on fundamentals Clarification of the underlying physical processes Applications of fluid mechanics in the natural environment

Investigations of Nitrogen Oxide Plasmas: Fundamental Chemistry and Surface Reactivity and Monitoring Student Perceptions in a General Chemistry Recitation

ERIC Educational Resources Information Center

Blechle, Joshua M.

2016-01-01

Part I of this dissertation focuses on investigations of nitrogen oxide plasma systems. With increasing concerns over the environmental presence of NxOy species, there is growing interest in utilizing plasma-assisted conversion techniques. Advances, however, have been limited because of the lack of knowledge regarding the fundamental chemistry of…

Human white matter and knowledge representation

PubMed Central

2018-01-01

Understanding how knowledge is represented in the human brain is a fundamental challenge in neuroscience. To date, most of the work on this topic has focused on knowledge representation in cortical areas and debated whether knowledge is represented in a distributed or localized fashion. Fang and colleagues provide evidence that brain connections and the white matter supporting such connections might play a significant role. The work opens new avenues of investigation, breaking through disciplinary boundaries across network neuroscience, computational neuroscience, cognitive science, and classical lesion studies. PMID:29698391

Human white matter and knowledge representation.

PubMed

Pestilli, Franco

2018-04-01

Understanding how knowledge is represented in the human brain is a fundamental challenge in neuroscience. To date, most of the work on this topic has focused on knowledge representation in cortical areas and debated whether knowledge is represented in a distributed or localized fashion. Fang and colleagues provide evidence that brain connections and the white matter supporting such connections might play a significant role. The work opens new avenues of investigation, breaking through disciplinary boundaries across network neuroscience, computational neuroscience, cognitive science, and classical lesion studies.

Direction discovery: A science enrichment program for high school students.

PubMed

Sikes, Suzanne S; Schwartz-Bloom, Rochelle D

2009-03-01

Launch into education about pharmacology (LEAP) is an inquiry-based science enrichment program designed to enhance competence in biology and chemistry and foster interest in science careers especially among under-represented minorities. The study of how drugs work, how they enter cells, alter body chemistry, and exit the body engages students to conceptualize fundamental precepts in biology, chemistry, and math. Students complete an intensive three-week course in the fundamentals of pharmacology during the summer followed by a mentored research component during the school year. Following a 5E learning paradigm, the summer course captures student interest by introducing controversial topics in pharmacology and provides a framework that guides them to explore topics in greater detail. The 5E learning cycle is recapitulated as students extend their knowledge to design and to test an original research question in pharmacology. LEAP students demonstrated significant gains in biology and chemistry knowledge and interests in pursuing science. Several students earned honors for the presentation of their research in regional and state science fairs. Success of the LEAP model in its initial 2 years argues that coupling college-level coursework of interest to teens with an authentic research experience enhances high school student success in and enthusiasm for science. Copyright © 2009 International Union of Biochemistry and Molecular Biology, Inc.

Introduction to the special issue: parsimony and redundancy in models of language.

PubMed

Wiechmann, Daniel; Kerz, Elma; Snider, Neal; Jaeger, T Florian

2013-09-01

One of the most fundamental goals in linguistic theory is to understand the nature of linguistic knowledge, that is, the representations and mechanisms that figure in a cognitively plausible model of human language-processing. The past 50 years have witnessed the development and refinement of various theories about what kind of 'stuff' human knowledge of language consists of, and technological advances now permit the development of increasingly sophisticated computational models implementing key assumptions of different theories from both rationalist and empiricist perspectives. The present special issue does not aim to present or discuss the arguments for and against the two epistemological stances or discuss evidence that supports either of them (cf. Bod, Hay, & Jannedy, 2003; Christiansen & Chater, 2008; Hauser, Chomsky, & Fitch, 2002; Oaksford & Chater, 2007; O'Donnell, Hauser, & Fitch, 2005). Rather, the research presented in this issue, which we label usage-based here, conceives of linguistic knowledge as being induced from experience. According to the strongest of such accounts, the acquisition and processing of language can be explained with reference to general cognitive mechanisms alone (rather than with reference to innate language-specific mechanisms). Defined in these terms, usage-based approaches encompass approaches referred to as experience-based, performance-based and/or emergentist approaches (Amrnon & Snider, 2010; Bannard, Lieven, & Tomasello, 2009; Bannard & Matthews, 2008; Chater & Manning, 2006; Clark & Lappin, 2010; Gerken, Wilson, & Lewis, 2005; Gomez, 2002;

Catalytic synthesis of ammonia-a "never-ending story"?

PubMed

Schlögl, Robert

2003-05-09

Nitrogen atoms are essential for the function of biological molecules and thus are and important component of fertilizers and medicaments. Bonds to nitrogen also find nonbiological uses in dyes, explosives, and resins. The synthesis of all these materials requires ammonia as an activated nitrogen building block. This situation is true for natural processes and the chemical industry. Knowledge of the various techniques for the preparation of ammonia is thus of fundamental importance for chemistry. The Haber-Bosch synthesis was the first heterogeneous catalytic system employed in the chemical industry and is still in use today. Understanding the mechanism and the translation of the knowledge into technical perfection has become a fundamental criterion for scientific development in catalysis research.

Interactive NMR: A Simulation Based Teaching Tool for Fundamentals to Applications with Tangible Analogies

NASA Astrophysics Data System (ADS)

Griesse-Nascimento, Sarah; Bridger, Joshua; Brown, Keith; Westervelt, Robert

2011-03-01

Interactive computer simulations increase students' understanding of difficult concepts and their ability to explain complex ideas. We created a module of eight interactive programs and accompanying lesson plans for teaching the fundamental concepts of Nuclear Magnetic Resonance (NMR) and Magnetic Resonance Imaging (MRI) that we call interactive NMR (iNMR). We begin with an analogy between nuclear spins and metronomes to start to build intuition about the dynamics of spins in a magnetic field. We continue to explain T1, T2, and pulse sequences with the metronome analogy. The final three programs are used to introduce and explain the Magnetic Resonance Switch, a recent diagnostic technique based on NMR. A modern relevant application is useful to generate interest in the topic and confidence in the students' ability to apply their knowledge. The iNMR module was incorporated into a high school AP physics class. In a preliminary evaluation of implementation, students expressed enthusiasm and demonstrated enhanced understanding of the material relative to the previous year. Funded by NSF PHY-0646094 grant.

Noise-like pulse generation in an ytterbium-doped fiber laser using tungsten disulphide

NASA Astrophysics Data System (ADS)

Zhang, Wenping; Song, Yanrong; Guoyu, Heyang; Xu, Runqin; Dong, Zikai; Li, Kexuan; Tian, Jinrong; Gong, Shuang

2017-12-01

We demonstrated the noise-like pulse (NLP) generation in an ytterbium-doped fiber (YDF) laser with tungsten disulphide (WS2). Stable fundamental mode locking and second-order harmonic mode locking were observed. The saturable absorber (SA) was a WS2-polyvinyl alcohol film. The modulation depth of the WS2 film was 2.4%, and the saturable optical intensity was 155 MW cm-2. Based on this SA, the fundamental NLP with a pulse width of 20 ns and repetition rate of 7 MHz were observed. The autocorrelation trace of output pulses had a coherent spike, which came from NLP. The average pulse width of the spike was 550 fs on the top of a broad pedestal. The second-order harmonic NLP had a spectral bandwidth of 1.3 nm and pulse width of 10 ns. With the pump power of 400 mW, the maximum output power was 22.2 mW. To the best of our knowledge, this is the first time a noise-like mode locking in an YDF laser based on WS2-SA in an all normal dispersion regime was obtained.

Can qualitative research play a role in answering ethical questions in intensive care?

PubMed

Meunier-Beillard, Nicolas; Ecarnot, Fiona; Rigaud, Jean-Philippe; Quenot, Jean-Pierre

2017-12-01

Scientific and technological progress, as well as increased patient autonomy have profoundly changed the world of healthcare, giving rise to new situations that are increasingly complex and uncertain. Quantitative paradigms, of which the main bastion is evidence-based medicine (EBM), are beginning to reach their limits in daily routine practice of medicine, and new approaches are emerging that can provide novel heuristic perspectives. Qualitative research approaches can be useful for apprehending new areas of knowledge that are fundamental to recent and future developments in intensive care.

Can qualitative research play a role in answering ethical questions in intensive care?

PubMed Central

Ecarnot, Fiona; Rigaud, Jean-Philippe; Quenot, Jean-Pierre

2017-01-01

Scientific and technological progress, as well as increased patient autonomy have profoundly changed the world of healthcare, giving rise to new situations that are increasingly complex and uncertain. Quantitative paradigms, of which the main bastion is evidence-based medicine (EBM), are beginning to reach their limits in daily routine practice of medicine, and new approaches are emerging that can provide novel heuristic perspectives. Qualitative research approaches can be useful for apprehending new areas of knowledge that are fundamental to recent and future developments in intensive care. PMID:29302601

The development of photoemission spectroscopy and its application to the study of semiconductor interfaces Observations on the interplay between basic and applied research (Welch Memorial Lecture)

NASA Technical Reports Server (NTRS)

Spicer, W. E.

1985-01-01

A sketch is given of the development of photoemission electron spectroscopy (PES) with emphasis on the author's own experience. Emphasis is placed: (1) on the period between 1958-1970; (2) on the various developments which were required for PES to emerge; and (3) on the strong interactions between applied/fundamental and knowledge/empirically based research. A more detailed discussion is given of the recent (1975-present) application of PES to study the interfaces of III-V semiconductors.

Empirical study of fuzzy compatibility measures and aggregation operators

NASA Astrophysics Data System (ADS)

Cross, Valerie V.; Sudkamp, Thomas A.

1992-02-01

Two fundamental requirements for the generation of support using incomplete and imprecise information are the ability to measure the compatibility of discriminatory information with domain knowledge and the ability to fuse information obtained from disparate sources. A generic architecture utilizing the generalized fuzzy relational database model has been developed to empirically investigate the support generation capabilities of various compatibility measures and aggregation operators. This paper examines the effectiveness of combinations of compatibility measures from the set-theoretic, geometric distance, and logic- based classes paired with t-norm and generalized mean families of aggregation operators.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Reiche, Helmut Matthias; Vogel, Sven C.

New in situ data for the U-C system are presented, with the goal of improving knowledge of the phase diagram to enable production of new ceramic fuels. The none quenchable, cubic, δ-phase, which in turn is fundamental to computational methods, was identified. Rich datasets of the formation synthesis of uranium carbide yield kinetics data which allow the benchmarking of modeling, thermodynamic parameters etc. The order-disorder transition (carbon sublattice melting) was observed due to equal sensitivity of neutrons to both elements. This dynamic has not been accurately described in some recent simulation-based publications.

Capturing domain knowledge from multiple sources: the rare bone disorders use case.

PubMed

Groza, Tudor; Tudorache, Tania; Robinson, Peter N; Zankl, Andreas

2015-01-01

Lately, ontologies have become a fundamental building block in the process of formalising and storing complex biomedical information. The community-driven ontology curation process, however, ignores the possibility of multiple communities building, in parallel, conceptualisations of the same domain, and thus providing slightly different perspectives on the same knowledge. The individual nature of this effort leads to the need of a mechanism to enable us to create an overarching and comprehensive overview of the different perspectives on the domain knowledge. We introduce an approach that enables the loose integration of knowledge emerging from diverse sources under a single coherent interoperable resource. To accurately track the original knowledge statements, we record the provenance at very granular levels. We exemplify the approach in the rare bone disorders domain by proposing the Rare Bone Disorders Ontology (RBDO). Using RBDO, researchers are able to answer queries, such as: "What phenotypes describe a particular disorder and are common to all sources?" or to understand similarities between disorders based on divergent groupings (classifications) provided by the underlying sources. RBDO is available at http://purl.org/skeletome/rbdo. In order to support lightweight query and integration, the knowledge captured by RBDO has also been made available as a SPARQL Endpoint at http://bio-lark.org/se_skeldys.html.

Improving care and wellness in bipolar disorder: origins, evolution and future directions of a collaborative knowledge exchange network

PubMed Central

2012-01-01

The Collaborative RESearch team to study psychosocial factors in bipolar disorder (CREST.BD) is a multidisciplinary, cross-sectoral network dedicated to both fundamental research and knowledge exchange on bipolar disorder (BD). The core mission of the network is to advance the science and understanding of psychological and social issues associated with BD, improve the care and wellness of people living with BD, and strengthen services and supports for these individuals. CREST.BD bridges traditional and newer research approaches, particularly embracing community-based participatory research (CBPR) methods. Membership of CREST is broad, including academic researchers, people with BD, their family members and supports, and a variety of health care providers. Here, we describe the origins, evolution, approach to planning and evaluation and future vision for our network within the landscape of CBPR and integrated knowledge translation (KT), and explore the keys and challenges to success we have encountered working within this framework. PMID:22963889

[Marxism as a theoretical and methodological framework in collective health: implications for systematic review and synthesis of evidence].

PubMed

Soares, Cassia Baldini; Campos, Celia Maria Sivalli; Yonekura, Tatiana

2013-12-01

In this study, we discuss the integration in systematic reviews of research developed from a Marxist perspective of knowledge production and their results as evidence in healthcare. The study objectives are to review the assumptions of dialectical and historical materialism (DHM) and discuss the implications of dialectics for a literature review and the synthesis of evidence. DHM is a powerful framework for knowledge generation and transformation of policies and practices in healthcare. It assumes that social contradictions underlie the health-disease process, the fundamental theoretical construction in the field of collective health. Currently, we observe a considerable influence of the critical paradigm, of Marxist origin, in the construction of knowledge in health. Studies based on this critical paradigm incorporate complex methods, which are inherent to the guidelines of dialect, to identify the object and arrive at results that constitute evidence in healthcare. Systematic reviews should address the methodological difficulties associated with entirely integrating these results to healthcare.

AI and simulation: What can they learn from each other

NASA Technical Reports Server (NTRS)

Colombano, Silvano P.

1988-01-01

Simulation and Artificial Intelligence share a fertile common ground both from a practical and from a conceptual point of view. Strengths and weaknesses of both Knowledge Based System and Modeling and Simulation are examined and three types of systems that combine the strengths of both technologies are discussed. These types of systems are a practical starting point, however, the real strengths of both technologies will be exploited only when they are combined in a common knowledge representation paradigm. From an even deeper conceptual point of view, one might even argue that the ability to reason from a set of facts (i.e., Expert System) is less representative of human reasoning than the ability to make a model of the world, change it as required, and derive conclusions about the expected behavior of world entities. This is a fundamental problem in AI, and Modeling Theory can contribute to its solution. The application of Knowledge Engineering technology to a Distributed Processing Network Simulator (DPNS) is discussed.

Multi-Disciplinary Knowledge Synthesis for Human Health Assessment on Earth and in Space

NASA Astrophysics Data System (ADS)

Christakos, G.

We discuss methodological developments in multi-disciplinary knowledge synthesis (KS) of human health assessment. A theoretical KS framework can provide the rational means for the assimilation of various information bases (general, site-specific etc.) that are relevant to the life system of interest. KS-based techniques produce a realistic representation of the system, provide a rigorous assessment of the uncertainty sources, and generate informative health state predictions across space-time. The underlying epistemic cognition methodology is based on teleologic criteria and stochastic logic principles. The mathematics of KS involves a powerful and versatile spatiotemporal random field model that accounts rigorously for the uncertainty features of the life system and imposes no restriction on the shape of the probability distributions or the form of the predictors. KS theory is instrumental in understanding natural heterogeneities, assessing crucial human exposure correlations and laws of physical change, and explaining toxicokinetic mechanisms and dependencies in a spatiotemporal life system domain. It is hoped that a better understanding of KS fundamentals would generate multi-disciplinary models that are useful for the maintenance of human health on Earth and in Space.

A comparative study on first-time and experienced project-based learning students in an engineering design module

NASA Astrophysics Data System (ADS)

Chua, K. J.

2014-09-01

This study aims to compare and evaluate the learning ability and performance differences between two groups of students undergoing project-based learning (PjBL), with one group having prior PjBL experience, while the other group is being freshly exposed to PjBL. More specifically, it examines if there are significant differences in knowledge score, problem-solving ability, and eventual project-deliverable outcomes between the two sets of students. Performances were compared via qualitative and quantitative analyses. Key findings have indicated a significant increase in fundamental formative knowledge; enhanced problem-solving abilities; and production of better performing artefacts with regard to the set of design skills between experienced and first-time PjBL groups. This study also highlighted that experienced PjBL students have less conflicts within their groups, and are more receptive to PjBL compared to first-time PjBL students. Results from this study provide a starting point for educators to seek new learning/facilitating strategies that are relevant based on the experience and learning styles of students.

Genetic and Epigenetic Contributions to Human Nutrition and Health: Managing Genome–Diet Interactions

PubMed Central

STOVER, PATRICK J.; CAUDILL, MARIE A.

2017-01-01

The Institute of Medicine recently convened a workshop to review the state of the various domains of nutritional genomics research and policy and to provide guidance for further development and translation of this knowledge into nutrition practice and policy. Nutritional genomics holds the promise to revolutionize both clinical and public health nutrition practice and facilitate the establishment of (a) genome-informed nutrient and food-based dietary guidelines for disease prevention and healthful aging, (b) individualized medical nutrition therapy for disease management, and (c) better targeted public health nutrition interventions (including micronutrient fortification and supplementation) that maximize benefit and minimize adverse outcomes within genetically diverse human populations. As the field of nutritional genomics matures, which will include filling fundamental gaps in knowledge of nutrient–genome interactions in health and disease and demonstrating the potential benefits of customizing nutrition prescriptions based on genetics, registered dietitians will be faced with the opportunity of making genetically driven dietary recommendations aimed at improving human health. PMID:18755320

Clinical, information and business process modeling to promote development of safe and flexible software.

PubMed

Liaw, Siaw-Teng; Deveny, Elizabeth; Morrison, Iain; Lewis, Bryn

2006-09-01

Using a factorial vignette survey and modeling methodology, we developed clinical and information models - incorporating evidence base, key concepts, relevant terms, decision-making and workflow needed to practice safely and effectively - to guide the development of an integrated rule-based knowledge module to support prescribing decisions in asthma. We identified workflows, decision-making factors, factor use, and clinician information requirements. The Unified Modeling Language (UML) and public domain software and knowledge engineering tools (e.g. Protégé) were used, with the Australian GP Data Model as the starting point for expressing information needs. A Web Services service-oriented architecture approach was adopted within which to express functional needs, and clinical processes and workflows were expressed in the Business Process Execution Language (BPEL). This formal analysis and modeling methodology to define and capture the process and logic of prescribing best practice in a reference implementation is fundamental to tackling deficiencies in prescribing decision support software.

Going DEEP: guidelines for building simulation-based team assessments.

PubMed

Grand, James A; Pearce, Marina; Rench, Tara A; Chao, Georgia T; Fernandez, Rosemarie; Kozlowski, Steve W J

2013-05-01

Whether for team training, research or evaluation, making effective use of simulation-based technologies requires robust, reliable and accurate assessment tools. Extant literature on simulation-based assessment practices has primarily focused on scenario and instructional design; however, relatively little direct guidance has been provided regarding the challenging decisions and fundamental principles related to assessment development and implementation. The objective of this manuscript is to introduce a generalisable assessment framework supplemented by specific guidance on how to construct and ensure valid and reliable simulation-based team assessment tools. The recommendations reflect best practices in assessment and are designed to empower healthcare educators, professionals and researchers with the knowledge to design and employ valid and reliable simulation-based team assessments. Information and actionable recommendations associated with creating assessments of team processes (non-technical 'teamwork' activities) and performance (demonstration of technical proficiency) are presented which provide direct guidance on how to Distinguish the underlying competencies one aims to assess, Elaborate the measures used to capture team member behaviours during simulation activities, Establish the content validity of these measures and Proceduralise the measurement tools in a way that is systematically aligned with the goals of the simulation activity while maintaining methodological rigour (DEEP). The DEEP framework targets fundamental principles and critical activities that are important for effective assessment, and should benefit healthcare educators, professionals and researchers seeking to design or enhance any simulation-based assessment effort.

An exploratory mixed-methods crossover study comparing DVD- vs. Web-based patient decision support in three conditions: The importance of patient perspectives.

PubMed

Halley, Meghan C; Rendle, Katharine A S; Gillespie, Katherine A; Stanley, Katherine M; Frosch, Dominick L

2015-12-01

The last 15 years have witnessed considerable progress in the development of decision support interventions (DESIs). However, fundamental questions about design and format of delivery remain. An exploratory, randomized mixed-method crossover study was conducted to compare a DVD- and Web-based DESI. Randomized participants used either the Web or the DVD first, followed by the alternative format. Participants completed a questionnaire to assess decision-specific knowledge at baseline and a questionnaire and structured qualitative interview after viewing each format. Tracking software was used to capture Web utilization. Transcripts were analyzed using integrated inductive and deductive approaches. Quantitative data were analyzed using exploratory bivariate and multivariate analyses. Exploratory knowledge analyses suggest that both formats increased knowledge, with limited evidence that the DVD increased knowledge more than the Web. Format preference varied across participants: 44% preferred the Web, 32% preferred the DVD and 24% preferred 'both'. Patient discussions of preferences for DESI information structure and the importance of a patients' stage of a given decision suggest these characteristics may be important factors underlying variation in utilization, format preferences and knowledge outcomes. Our results suggest that both DESI formats effectively increase knowledge. Patients' perceptions of these two formats further suggest that there may be no single 'best' format for all patients. These results have important implications for understanding why different DESI formats might be preferable to and more effective for different patients. Further research is needed to explore the relationship between these factors and DESI utilization outcomes across diverse patient populations. © 2014 John Wiley & Sons Ltd.

Baseline evidence-based practice use, knowledge, and attitudes of allied health professionals: a survey to inform staff training and organisational change.

PubMed

Wilkinson, Shelley A; Hinchliffe, Fiona; Hough, Judith; Chang, Anne

2012-01-01

Evidence-based practice (EBP) is fundamental to improving patient outcomes. Universal adoption of EBP into the allied health clinical setting has not yet occurred. The primary aim of this project was to capture baseline measurements of the level of EBP self-efficacy, outcome expectancy, knowledge and use at our health service prior to training and organisational changes to support EBP. All allied health staff (n=252) employed across the campus were invited to participate in an online survey consisting of a battery of validated and reliable survey tools. Professional background, knowledge and previous training in EBP and research processes were collected. One hundred eighty-two allied health staff completed the survey (response rate 72%). One-way ANOVAs were used to compare levels of self-efficacy, outcome expectancy, knowledge and use, according to allied health discipline and experience with EBP and research processes. Mean scores for EBP attitudes (self-efficacy and outcome expectancy) and knowledge were higher than for use. Professional group differences were noted in the post-hoc analysis of the significant EBP constructs. Regression analyses indicated that EBP course attendance as well as training in research design and analysis impacted positively on EBP construct scores. Despite positive attitudes about, a belief in and knowledge of EBP, self-reports of EBP processes do not indicate systematic application in the allied health workplace. The results of this research will inform a targeted intervention to foster ongoing training in EBP and research activity for allied health staff.

"BioONT": Improving Knowledge Organization and Representation in the Domain of Biometric Authentication

ERIC Educational Resources Information Center

Buerle, Stephen

2017-01-01

This dissertation explores some of the fundamental challenges facing the information assurance community as it relates to knowledge categorization, organization and representation within the field of information security and more specifically within the domain of biometric authentication. A primary objective of this research is the development of…

Fostering Second Graders' Scientific Explanations: A Beginning Elementary Teacher's Knowledge, Beliefs, and Practice

ERIC Educational Resources Information Center

Beyer, Carrie J.; Davis, Elizabeth A.

2008-01-01

Teaching science as explanation is fundamental to reform efforts but is challenging for teachers--especially new elementary teachers, for whom the complexities of teaching are compounded by high demands and little classroom experience. Despite these challenges, few studies have characterized the knowledge, beliefs, and instructional practices that…

Encouraging Civic Knowledge and Engagement: Exploring Current Events through a Psychological Lens

ERIC Educational Resources Information Center

Van Camp, Debbie; Baugh, Stacey-Ann

2016-01-01

Engagement with political, social, and civil issues is a fundamental component of an educated population, but civic knowledge and engagement are decreasing among adolescents and young adults. A Psychology in Current Events class sought to increase this engagement and key skills such as critical thinking. A one-group pretest-posttest…

A Comparison of Student Skill Knowledge Estimates

ERIC Educational Resources Information Center

Ayers, Elizabeth; Nugent, Rebecca; Dean, Nema

2009-01-01

A fundamental goal of educational research is identifying students' current stage of skill mastery (complete/partial/none). In recent years a number of cognitive diagnosis models have become a popular means of estimating student skill knowledge. However, these models become difficult to estimate as the number of students, items, and skills grows.…

Operationalizing Place: Discovering, Reasoning about, and Exploring Place Knowledge from Descriptions

ERIC Educational Resources Information Center

Adams, Benjamin Thomas

2012-01-01

Places and place types, such as "small town", play a fundamental role in how people organize knowledge about the world. Although places are commonly referenced in human communication, often they are not canonically defined and many of the properties people associate with them have proved difficult to operationalize. In information…

Knowledge Gained from Good Agricultural Practices Courses for Iowa Growers

ERIC Educational Resources Information Center

Shaw, Angela; Strohbehn, Catherine; Naeve, Linda; Domoto, Paul; Wilson, Lester

2015-01-01

Good Agricultural Practices (GAP) educational courses provide produce growers with the fundamental information for producing and processing safe produce. To determine the effectiveness of the current 7-hour GAP course provided in Iowa, growers were surveyed before and 7-14 days after the course to determine changes in knowledge and opinions.…

Data Mining in Finance: Using Counterfactuals To Generate Knowledge from Organizational Information Systems.

ERIC Educational Resources Information Center

Dhar, Vasant

1998-01-01

Shows how counterfactuals and machine learning methods can be used to guide exploration of large databases that addresses some of the fundamental problems that organizations face in learning from data. Discusses data mining, particularly in the financial arena; generating useful knowledge from data; and the evaluation of counterfactuals. (LRW)

ESLl Teachers' Knowledge of and Experience with Written Corrective Feedback

ERIC Educational Resources Information Center

Cao, Peihong

2017-01-01

Written Corrective Feedback (WCF) in writing classes is fundamental to interactions between teachers and students about students' writing and to help students further improve their writing. As one of the main feedback sources, teachers' cognition (e.g., teachers' thoughts, knowledge, and beliefs) needs to be probed to properly understand teachers…

Methodological Developments in Geophysical Assimilation Modeling

NASA Astrophysics Data System (ADS)

Christakos, George

2005-06-01

This work presents recent methodological developments in geophysical assimilation research. We revisit the meaning of the term "solution" of a mathematical model representing a geophysical system, and we examine its operational formulations. We argue that an assimilation solution based on epistemic cognition (which assumes that the model describes incomplete knowledge about nature and focuses on conceptual mechanisms of scientific thinking) could lead to more realistic representations of the geophysical situation than a conventional ontologic assimilation solution (which assumes that the model describes nature as is and focuses on form manipulations). Conceptually, the two approaches are fundamentally different. Unlike the reasoning structure of conventional assimilation modeling that is based mainly on ad hoc technical schemes, the epistemic cognition approach is based on teleologic criteria and stochastic adaptation principles. In this way some key ideas are introduced that could open new areas of geophysical assimilation to detailed understanding in an integrated manner. A knowledge synthesis framework can provide the rational means for assimilating a variety of knowledge bases (general and site specific) that are relevant to the geophysical system of interest. Epistemic cognition-based assimilation techniques can produce a realistic representation of the geophysical system, provide a rigorous assessment of the uncertainty sources, and generate informative predictions across space-time. The mathematics of epistemic assimilation involves a powerful and versatile spatiotemporal random field theory that imposes no restriction on the shape of the probability distributions or the form of the predictors (non-Gaussian distributions, multiple-point statistics, and nonlinear models are automatically incorporated) and accounts rigorously for the uncertainty features of the geophysical system. In the epistemic cognition context the assimilation concept may be used to investigate critical issues related to knowledge reliability, such as uncertainty due to model structure error (conceptual uncertainty).

Cross-National Analysis of Islamic Fundamentalism

DTIC Science & Technology

2016-01-20

attitudes, and was fully involved in activities concerning questionnaire design including a new experimental design in the survey, pilot testing, and...possible collaboration with the research design of the panel survey in Tunisia. • Data analysis: Analyses of religious fundamentalism, women’s dress, trust...the Event History Calendar and the best methods to ask about knowledge and experience of past events. The group designed a series of cognitive

MedRapid--medical community & business intelligence system.

PubMed

Finkeissen, E; Fuchs, H; Jakob, T; Wetter, T

2002-01-01

currently, it takes at least 6 months for researchers to communicate their results. This delay is caused (a) by partial lacks of machine support for both representation as well as communication and (b) by media breaks during the communication process. To make an integrated communication between researchers and practitioners possible, a general structure for medical content representation has been set up. The procedure for data entry and quality management has been generalized and implemented in a web-based authoring system. The MedRapid-system supports the medical experts in entering their knowledge into a database. Here, the level of detail is still below that of current medical guidelines representation. However, the symmetric structure for an area-wide medical knowledge representation is highly retrievable and thus can quickly be communicated into daily routine for the improvement of the treatment quality. In addition, other sources like journal articles and medical guidelines can be references within the MedRapid-system and thus be communicated into daily routine. The fundamental system for the representation of medical reference knowledge (from reference works/books) itself is not sufficient for the friction-less communication amongst medical staff. Rather, the process of (a) representing medical knowledge, (b) refereeing the represented knowledge, (c) communicating the represented knowledge, and (d) retrieving the represented knowledge has to be unified. MedRapid will soon support the whole process on one server system.

Knowledge engineering in volcanology: Practical claims and general approach

NASA Astrophysics Data System (ADS)

Pshenichny, Cyril A.

2014-10-01

Knowledge engineering, being a branch of artificial intelligence, offers a variety of methods for elicitation and structuring of knowledge in a given domain. Only a few of them (ontologies and semantic nets, event/probability trees, Bayesian belief networks and event bushes) are known to volcanologists. Meanwhile, the tasks faced by volcanology and the solutions found so far favor a much wider application of knowledge engineering, especially tools for handling dynamic knowledge. This raises some fundamental logical and mathematical problems and requires an organizational effort, but may strongly improve panel discussions, enhance decision support, optimize physical modeling and support scientific collaboration.

Cadaver-Based Simulation Increases Resident Confidence, Initial Exposure to Fundamental Techniques, and May Augment Operative Autonomy.

PubMed

Kim, Steven C; Fisher, Jeremy G; Delman, Keith A; Hinman, Johanna M; Srinivasan, Jahnavi K

Surgical simulation is an important adjunct in surgical education. The majority of operative procedures can be simplified to core components. This study aimed to quantify a cadaver-based simulation course utility in improving exposure to fundamental maneuvers, resident and attending confidence in trainee capability, and if this led to earlier operative independence. A list of fundamental surgical procedures was established by a faculty panel. Residents were assigned to a group led by a chief resident. Residents performed skills on cadavers appropriate for PGY level. A video-recorded examination where they narrated and demonstrated a task independently was then graded by attendings using standardized rubrics. Participants completed surveys regarding improvements in knowledge and confidence. The course was conducted at the Emory University School of Medicine and the T3 Laboratories in Atlanta, GA. A total of 133 residents and 41 attendings participated in the course. 133 (100%) participating residents and 32 (78%) attendings completed surveys. Resident confidence in completing the assigned skill independently increased from 3 (2-3) to 4 (3-4), p < 0.01. Residents stated that a median of 40% (interquartile range: 20%-60%) of procedures were performed for the first time in the course, and the same number had been performed only in the course. The percentage of skills attendings believed residents could perform independently increased from 40% (40%-60%) to 60% (60%->80%), p < 0.04. Attendings were more likely to grant autonomy in the operating room after this exercise (4 [3-5]). A cadaveric skills course focused on fundamental maneuvers with objective confirmation of success is a viable adjunct to clinical operative experience. Residents were formally exposed to fundamental surgical maneuvers earlier as a result of this course. This activity improved both resident and attending confidence in trainee operative skill, resulting in increased attending willingness to grant a higher level of autonomy in the operating room. Copyright © 2016 Association of Program Directors in Surgery. Published by Elsevier Inc. All rights reserved.

“Docs 'n Drugs” - A System for Case-Oriented and Web-based Training in Medicine

PubMed Central

Martens, A.; Bernauer, J.

1999-01-01

The tutoring process of conventional case-oriented medical training systems can be characterised as either guided or unguided. In contrast to that, the aim of the system “Docs'n Drugs” is to distinguish between different levels of guidance. The author can realise the tutoring case either as a guided, a half guided or a unguided tutoring process. The system architecture distinguishes between an authoring system and a tutoring system. Fundaments of these are the tutoring process model and the case-based knowledge model. This structure allows the reuse of elements of existing tutoring cases. The tutoring cases can be realised in German and English.

Thermophysical and tribological properties of nanolubricants: A review

NASA Astrophysics Data System (ADS)

Kotia, Ankit; Rajkhowa, Pranami; Rao, Gogineni Satyanarayana; Ghosh, Subrata Kumar

2018-05-01

Recent studies in heat transfer evident that the nanofluid shows better heat transfer results as compared to base fluid. This influences the research community for the dispersion of nanoparticles in lubricants to enhance its thermophysical and tribological properties and these suspensions are termed as Nanolubricants. This review focuses on the effect of nanoparticle additives on thermophysical and tribological properties of base lubricant. Initial section briefly summarizes the variation in thermophysical properties namely viscosity, thermal conductivity, density and specific heat of nanolubricants. In later section, the coefficient of friction and anti-wear properties of nanolubricants are summarized. This review along with the replenishment of current knowledge, also discusses the fundamental mechanisms that evolve with the dispersion of nanoparticles.

Ground-Based Gas-Liquid Flow Research in Microgravity Conditions: State of Knowledge

NASA Technical Reports Server (NTRS)

McQuillen, J.; Colin, C.; Fabre, J.

1999-01-01

During the last decade, ground-based microgravity facilities have been utilized in order to obtain predictions for spacecraft system designers and further the fundamental understanding of two-phase flow. Although flow regime, pressure drop and heat transfer coefficient data has been obtained for straight tubes and a limited number of fittings, measurements of the void fraction, film thickness, wall shear stress, local velocity and void information are also required in order to develop general mechanistic models that can be utilized to ascertain the effects of fluid properties, tube geometry and acceleration levels. A review of this research is presented and includes both empirical data and mechanistic models of the flow behavior.

Summary report of a workshop on research opportunities in plant biochemistry, December 11--13, 1992, Kona, Hawaii

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1992-12-31

A DOE-sponsored workshop was held December 11--13, 1992 in Kona, Hawaii to discuss those aspects of fundamental research in plant biochemistry deemed essential to provide the basic information base necessary for exploiting plant biotechnology to meet future societal needs. Twenty nine scientists, with interests representing many of the various areas of plant biochemistry, participated. The workshop was intended to define in both broad and specific terms the current state of knowledge in the general area of metabolic biochemistry, and to identify those areas that afford unusual opportunity or that are relatively underdeveloped in comparison with other areas of plant biology.more » Participants provided critiques of the state of knowledge of the major areas of metabolic biochemistry in relation to a series of questions that are presented herein.« less

Anesthesiology and competitive strategy.

PubMed

Gross, Wendy L; Gold, Barbara

2009-03-01

Whether we like it or not, medicine is big business. The argument is sometimes made that standard management strategies from the business world do not apply to medicine because the economics and practice of medicine are unique--driven by science and rapid rates of change. But an exploding knowledge base, light-speed technological development, and ever-changing reimbursement schemes are not exclusive to medicine and health care. Some fundamental principles of finance, business management, and strategic development have evolved to deal with problems of rapid change. These principles do apply to modern medicine. The business side of anesthesia practice is off-putting to many clinicians. However, knowledge of the market forces at play can help enhance patient care, improve service, expand opportunities, and extend the perimeter of the discipline. The mission and current market position of anesthesiology practice are considered here.

Development and Evaluation of a Pharmacogenomics Educational Program for Pharmacists

PubMed Central

Formea, Christine M.; Nicholson, Wayne T.; McCullough, Kristen B.; Berg, Kevin D.; Berg, Melody L.; Cunningham, Julie L.; Merten, Julianna A.; Ou, Narith N.; Stollings, Joanna L.

2013-01-01

Objectives. To evaluate hospital and outpatient pharmacists’ pharmacogenomics knowledge before and 2 months after participating in a targeted, case-based pharmacogenomics continuing education program. Design. As part of a continuing education program accredited by the Accreditation Council for Pharmacy Education (ACPE), pharmacists were provided with a fundamental pharmacogenomics education program. Evaluation. An 11-question, multiple-choice, electronic survey instrument was distributed to 272 eligible pharmacists at a single campus of a large, academic healthcare system. Pharmacists improved their pharmacogenomics test scores by 0.7 questions (pretest average 46%; posttest average 53%, p=0.0003). Conclusions. Although pharmacists demonstrated improvement, overall retention of educational goals and objectives was marginal. These results suggest that the complex topic of pharmacogenomics requires a large educational effort in order to increase pharmacists’ knowledge and comfort level with this emerging therapeutic opportunity. PMID:23459098

Development and evaluation of a pharmacogenomics educational program for pharmacists.

PubMed

Formea, Christine M; Nicholson, Wayne T; McCullough, Kristen B; Berg, Kevin D; Berg, Melody L; Cunningham, Julie L; Merten, Julianna A; Ou, Narith N; Stollings, Joanna L

2013-02-12

Objectives. To evaluate hospital and outpatient pharmacists' pharmacogenomics knowledge before and 2 months after participating in a targeted, case-based pharmacogenomics continuing education program.Design. As part of a continuing education program accredited by the Accreditation Council for Pharmacy Education (ACPE), pharmacists were provided with a fundamental pharmacogenomics education program.Evaluation. An 11-question, multiple-choice, electronic survey instrument was distributed to 272 eligible pharmacists at a single campus of a large, academic healthcare system. Pharmacists improved their pharmacogenomics test scores by 0.7 questions (pretest average 46%; posttest average 53%, p=0.0003).Conclusions. Although pharmacists demonstrated improvement, overall retention of educational goals and objectives was marginal. These results suggest that the complex topic of pharmacogenomics requires a large educational effort in order to increase pharmacists' knowledge and comfort level with this emerging therapeutic opportunity.

The Essential Role for Laboratory Studies in Atmospheric Chemistry.

PubMed

Burkholder, James B; Abbatt, Jonathan P D; Barnes, Ian; Roberts, James M; Melamed, Megan L; Ammann, Markus; Bertram, Allan K; Cappa, Christopher D; Carlton, Annmarie G; Carpenter, Lucy J; Crowley, John N; Dubowski, Yael; George, Christian; Heard, Dwayne E; Herrmann, Hartmut; Keutsch, Frank N; Kroll, Jesse H; McNeill, V Faye; Ng, Nga Lee; Nizkorodov, Sergey A; Orlando, John J; Percival, Carl J; Picquet-Varrault, Bénédicte; Rudich, Yinon; Seakins, Paul W; Surratt, Jason D; Tanimoto, Hiroshi; Thornton, Joel A; Tong, Zhu; Tyndall, Geoffrey S; Wahner, Andreas; Weschler, Charles J; Wilson, Kevin R; Ziemann, Paul J

2017-03-07

Laboratory studies of atmospheric chemistry characterize the nature of atmospherically relevant processes down to the molecular level, providing fundamental information used to assess how human activities drive environmental phenomena such as climate change, urban air pollution, ecosystem health, indoor air quality, and stratospheric ozone depletion. Laboratory studies have a central role in addressing the incomplete fundamental knowledge of atmospheric chemistry. This article highlights the evolving science needs for this community and emphasizes how our knowledge is far from complete, hindering our ability to predict the future state of our atmosphere and to respond to emerging global environmental change issues. Laboratory studies provide rich opportunities to expand our understanding of the atmosphere via collaborative research with the modeling and field measurement communities, and with neighboring disciplines.

Communicating the Value of Science--Issues, Imperatives and Insights

NASA Astrophysics Data System (ADS)

Gan, J.; Topousis, D.

2013-12-01

Over the last six decades, federal investments in scientific research have led to unquestionable economic and societal advances, while expanding human knowledge. Yet, in the current federal fiscal climate, funding for fundamental research is being challenged in some quarters. This situation has created the need for stakeholders in science to step forward and defend the role that basic research plays in creating the knowledge and workforce necessary to address current and future challenges. Communicating to fellow scientists in this environment is necessary but not sufficient to sustaining, or even expanding, support for fundamental research. A multi-faceted approach will be described for enhancing communication to broader audiences, including policy makers and the general public, increasingly responsible for ensuring the future of scientific progress.

Physiotherapists' perceptions of workplace competency: a mixed-methods observational study.

PubMed

Sturt, Rodney; Burge, Angela T; Harding, Paula; Sayer, James

2017-06-22

Objectives Workplace-based competency is increasingly considered fundamental to patient safety and quality healthcare. The aim of the present study was to identify and describe physiotherapists' perceptions of workplace competency. Methods The present study was a mixed-methods cross-sectional observational study. Thematic and descriptive analysis of qualitative and survey data were undertaken. Forty-six physiotherapists employed at a metropolitan acute public hospital participated in interviews or focus groups; a subgroup of 31 participants also completed an online survey. Results Five main themes were identified: (1) despite the availability of workplace learning opportunities and supports, less-experienced staff reported limited confidence; (2) assessment and feedback around workplace competency was limited, predominantly informal and unstructured, with less than half of the cohort (42%) agreeing feedback received was useful for improving their workplace skills; (3) practicing within individual scope is an important aspect of workplace competency as a physiotherapist; (4) most (81%) agreed it was important for them to self-determine their learning and development goals, and they relied primarily on informal discussion to achieve these goals; and, (5) physiotherapists felt motivated regarding workplace learning, with 97% interested in developing their workplace skills however, nearly half (45%) did not feel they had sufficient time to do so. Conclusions The perceptions of physiotherapists working in a metropolitan acute public hospital are reflected in five themes. These themes elucidate how workplace competency is supported, maintained and developed among physiotherapists in this setting. These themes also highlight key challenges of workplace learning faced by this cohort of physiotherapists and allude to methods that may assist with improving feedback mechanisms and knowledge acquisition. What is known about this topic? Studies investigating employee perceptions around workplace competency, knowledge, skills and learning are found across a range of industries. Workplace-based competency is increasingly considered fundamental to patient safety and quality health care. There is little known about physiotherapists' perceptions of workplace competency. What does this paper add? This study has identified and described themes around physiotherapists' perceptions of their workplace knowledge and skills. What are the implications for practitioners? The themes identified provide support for the development, implementation and evaluation of a workplace-based competency framework for physiotherapists.

78 FR 6119 - Submission for OMB Review; Comment Request: National Institutes of Health Information Collection...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-29

... National Institutes of Health (NIH) has submitted to the Office of Management and Budget (OMB) a request to... fundamental knowledge about the nature and behavior of living systems and the application of that knowledge to... associated response time, should be directed to the: Office of Management and Budget, Office of Regulatory...

Information into Knowledge: Navigating the Complexity in the Campus Community Engagement Context

ERIC Educational Resources Information Center

Middleton, Anne T.; Whitmore, Elizabeth

2017-01-01

In this paper we draw on two case studies from a current research project investigating the impact of campus-community engagement (CCE) to examine how the fundamental functions for effective knowledge mobilisation were used. The K* spectrum provides a mapping framework for analysis. Both the types of CCE and the different relationships developed…

Developing an English for Academic Purposes Course for L2 Graduate Students in the Sciences

ERIC Educational Resources Information Center

Douglas, Jennifer

2015-01-01

Graduate students face a fundamental change in identity when transitioning from undergraduate writers to graduate writers. In their new role as graduate writers and researchers, they must move from consuming knowledge to producing knowledge through their writing. Often, they must learn new genres of writing, new disciplinary conventions, and new…

Modern Education in China. Bulletin, 1919, No. 44

ERIC Educational Resources Information Center

Edmunds, Charles K.

1919-01-01

The Chinese conception of life's values is so different from that of western peoples that they have failed to develop modern technique and scientific knowledge. Now that they have come to see the value of these, rapid and fundamental changes are taking place. When modern scientific knowledge is added to the skill which the Chinese already have in…

"Everything Flows and Nothing Stays": How Students Make Sense of the Historical Concepts of Change, Continuity and Development

ERIC Educational Resources Information Center

Blow, Frances

2011-01-01

First order knowledge and understanding, relating to the "stuff" of history, is, of course, absolutely fundamental to the development of children's historical knowledge and understanding. However, as Frances Blow shows, in a contribution to a series of articles exploring second order concepts in history published in Teaching History by…

Foregrounding Equity in Teacher Education: Toward a Model of Social Justice Pedagogical and Content Knowledge

ERIC Educational Resources Information Center

Dyches, Jeanne; Boyd, Ashley

2017-01-01

Since its inception 30 years ago, Shulman's Pedagogical Content Knowledge (PCK) has fundamentally altered the landscape of teacher preparation. Despite its prominence in the field, the paradigm fails to delineate a space for the role of social justice in classroom practices and teacher preparation. Accordingly, we complicate the relationship…

Meeting the Discipline-Culture Framework of Physics Knowledge: A Teaching Experience in Italian Secondary School

ERIC Educational Resources Information Center

Levrini, Olivia; Bertozzi, Eugenio; Gagliardi, Marta; Tomasini, Nella Grimellini; Pecori, Barbara; Tasquier, Giulia; Galili, Igal

2014-01-01

The paper deals with physics teaching/learning in high school. An investigation in three upper secondary school classes in Italy explored the reactions of students to a structuring lecture on optics within the discipline-culture (DC) framework that organises physics knowledge around four interrelated fundamental theories of light. The lecture…

Neoliberalism, Higher Education and the Knowledge Economy: From the Free Market to Knowledge Capitalism

ERIC Educational Resources Information Center

Olssen, Mark; Peters, Michael A.

2005-01-01

The ascendancy of neoliberalism and the associated discourses of '[new public management', during the 1980s and 1990s has produced a fundamental shift in the way universities and other institutions of higher education have defined and justified their institutional existence. The traditional professional culture of open intellectual enquiry and…

Meeting of Minds and Futures: The Nature of Knowledge in Diverse Global Settings

ERIC Educational Resources Information Center

Odora Hoppers, Catherine A.; Sandgren, Björn

2014-01-01

When we think of communities of the future, we have to think of new social contracts between universities and society with a different ecology, and an intense compatibility towards transdisciplinarity. We know that today there is a need for truly fundamental reflections and questions on knowledge as the building block of global societies…

Prospective Turkish Elementary Science Teachers' Knowledge Level about the Greenhouse Effect and Their Views on Environmental Education in University

ERIC Educational Resources Information Center

Kisoglu, Mustafa; Gürbüz, Hasan; Erkol, Mehmet; Akar, Muhammed Said; Akilli, Mustafa

2010-01-01

The fundamental factor of environmental education is teachers who are well-informed about environmental issues. This research aimed to determine prospective Turkish elementary science teachers' knowledge level about causes, consequences and reducing of the greenhouse effect and to investigate the effect of gender, information source and membership…

Detecting the effects of forest harvesting on streamflow using hydrologic model change detection

Treesearch

Nicolas P. Zegre; Nicholas A. Som

2011-01-01

Knowledge of the effects of forest management on hydrology primarily comes from paired-catchment study experiments. This approach has contributed fundamental knowledge of the effects of forest management on hydrology, but results from these studies lack insight into catchment processes. Outlined in this study is an alternative method of change detection that uses a...

A national fundamentals curriculum for neurosurgery PGY1 residents: the 2010 Society of Neurological Surgeons boot camp courses.

PubMed

Selden, Nathan R; Origitano, Thomas C; Burchiel, Kim J; Getch, Christopher C; Anderson, Valerie C; McCartney, Shirley; Abdulrauf, Saleem I; Barrow, Daniel L; Ehni, Bruce L; Grady, M Sean; Hadjipanayis, Costas G; Heilman, Carl B; Popp, A John; Sawaya, Raymond; Schuster, James M; Wu, Julian K; Barbaro, Nicholas M

2012-04-01

In July 2009, the Accreditation Council for Graduate Medical Education (ACGME) incorporated postgraduate year 1 (PGY1 intern) level training into all U.S. neurosurgery residency programs. To provide a fundamentals curriculum for all incoming neurosurgery PGY1 residents in ACGME-accredited programs, including skills, knowledge, and attitudes that promote quality, patient safety, and professionalism. The Society of Neurological Surgeons organized 6 regional "boot camp" courses for incoming neurosurgery PGY1 residents in July 2010 that consisted of 9 lectures on clinical and nonclinical competencies plus 10 procedural and 6 surgical skills stations. Resident and faculty participants were surveyed to assess knowledge and course effectiveness. A total of 186 of 197 U.S. neurosurgical PGY1 residents (94%) and 75 neurosurgical faculty from 36 of 99 programs (36%) participated in the inaugural boot camp courses. All residents and 83% of faculty participants completed course surveys. All resident and faculty respondents thought that the boot camp courses fulfilled their purpose and objectives and imparted skills and knowledge that would improve patient care. PGY1 residents' knowledge of information taught in the courses improved significantly in postcourse testing (P < .0001). Residents and faculty particularly valued simulated and other hands-on skills training. Regional organization facilitated an unprecedented degree of participation in a national fundamental skills program for entering neurosurgery residents. One hundred percent of resident and faculty respondents positively reviewed the courses. The boot camp courses may provide a model for enhanced learning, professionalism, and safety at the inception of training in other procedural specialties.

"Bildung" and Moral Self-Cultivation in Higher Education: What Does It Mean and How Can It Be Achieved?

ERIC Educational Resources Information Center

Bohlin, Henrik

2008-01-01

One of the most fundamental questions that can be asked about education is what it is for. Why do we need education? Which are its most fundamental purposes? The most obvious and generally accepted answer is that education aims at providing students with knowledge and skills which match the demands of employers, thus enabling students to find jobs…

METAL OXIDE NANOPARTICLES

DOE Office of Scientific and Technical Information (OSTI.GOV)

FERNANDEZ-GARCIA,M.; RODGRIGUEZ, J.A.

2007-10-01

This chapter covers the fundamental science, synthesis, characterization, physicochemical properties and applications of oxide nanomaterials. Explains fundamental aspects that determine the growth and behavior of these systems, briefly examines synthetic procedures using bottom-up and top-down fabrication technologies, discusses the sophisticated experimental techniques and state of the art theory results used to characterize the physico-chemical properties of oxide solids and describe the current knowledge concerning key oxide materials with important technological applications.

The effectiveness of skills training for improving outcomes in supported employment.

PubMed

Mueser, Kim T; Aalto, Steve; Becker, Deborah R; Ogden, John S; Wolfe, Rosemarie S; Schiavo, Diane; Wallace, Charles J; Xie, Haiyi

2005-10-01

This study evaluated whether a supplementary skills training program improved work outcomes for clients enrolled in supported employment programs. Thirty-five recently employed clients with severe mental illness who were receiving supported employment services at a free-standing agency were randomly assigned to participate in either the workplace fundamentals program, a skills training program designed to make work more "successful and satisfying," or treatment as usual. Knowledge of workplace fundamentals (for example, identifying workplace stressors, problem solving, and improving job performance) was assessed at baseline and at nine months; employment outcomes and use of additional vocational services were tracked for 18 months. Clients in the workplace fundamentals group (N=17) improved more in knowledge of workplace fundamentals than those in the control group (N=18) at the nine-month follow-up, but the two groups did not differ in the number of hours or days worked, salary earned, or receipt of additional vocational services over the 18-month period. In general, clients in this study had higher educational levels and better employment outcomes than clients in most previous studies of supported employment, making it difficult to detect possible effects of the skills training intervention on work. Supplementary skills training did not improve work outcomes for clients who were receiving supported employment.

[From evidence-based medicine to value-based medicine].

PubMed

Zhang, Shao-dan; Liang, Yuan-bo; Li, Si-zhen

2006-11-01

Evidence base medicine (EBM) is based on objective evidence, which provides best available knowledge for physicians to scientifically make medical and therapeutic decisions for the care of all individual patients in order to improve the effectiveness of treatment and to prolong the life of patients. EBM has made a significant progress in clinical practice. But medical therapies cannot always bring a better life quality and clinically, patients' preference should be always taken into account. Value-based medicine medicine (VBM) is the practice of medicine that emphasizes the value received from an intervention. It takes evidence-based data to a higher level by combining the parameters of patient-perceived value with the cost of an intervention. The fundamental instrument of VBM is cost-utility analysis. VBM will provide a better practice model to evaluate the therapeutic package and cost effectiveness for individual and general health care.

The Emergence of Primary Anoetic Consciousness in Episodic Memory

PubMed Central

Vandekerckhove, Marie; Bulnes, Luis Carlo; Panksepp, Jaak

2014-01-01

Based on an interdisciplinary perspective, we discuss how primary-process, anoetic forms of consciousness emerge into higher forms of awareness such as knowledge-based episodic knowing and self-aware forms of higher-order consciousness like autonoetic awareness. Anoetic consciousness is defined as the rudimentary state of affective, homeostatic, and sensory-perceptual mental experiences. It can be considered as the autonomic flow of primary-process phenomenal experiences that reflects a fundamental form of first-person “self-experience,” a vastly underestimated primary form of phenomenal consciousness. We argue that this anoetic form of evolutionarily refined consciousness constitutes a critical antecedent that is foundational for all forms of knowledge acquisition via learning and memory, giving rise to a knowledge-based, or noetic, consciousness as well as higher forms of “awareness” or “knowing consciousness” that permits “time-travel” in the brain-mind. We summarize the conceptual advantages of such a multi-tiered neuroevolutionary approach to psychological issues, namely from genetically controlled primary (affective) and secondary (learning and memory), to higher tertiary (developmentally emergent) brain-mind processes, along with suggestions about how affective experiences become more cognitive and object-oriented, allowing the developmental creation of more subtle higher mental processes such as episodic memory which allows the possibility of autonoetic consciousness, namely looking forward and backward at one’s life and its possibilities within the “mind’s eye.” PMID:24427125

Social inequalities in adolescent human papillomavirus (HPV) vaccination: a test of fundamental cause theory.

PubMed

Polonijo, Andrea N; Carpiano, Richard M

2013-04-01

A unique contribution of the fundamental cause theory of health disparities is its ability to account for the persistence of disparities in health and mortality, despite changes in the mechanisms that are relevant at any given time. Few studies, however, have investigated how such mechanisms are created or operate. Examining the introduction of the human papillomavirus (HPV) vaccine for adolescents-a treatment aimed at preventing cervical and other cancers that typically emerge in mid- to late-adulthood-we empirically trace such a disparity-generating mechanism that is in the process of being latently created, testing whether socioeconomic status (SES) and racial/ethnic disparities exist for several facets of vaccination receipt: knowledge about the vaccine, receipt of a health professional recommendation to vaccinate, and initiation and completion of the three-shot vaccination series. Analyses of 2008, 2009, and 2010 United States National Immunization Survey-Teen data (n = 41,358) reveal disparities consistent with fundamental cause theory, particularly for vaccine knowledge and receipt of a health professional recommendation. While parental knowledge is a prerequisite to adolescent vaccine uptake, low SES and racial/ethnic minority parents have significantly lower odds of knowing about the vaccine. Receipt of a health professional's recommendation to vaccinate is strongly associated with vaccine uptake, however the odds of receiving a recommendation are negatively associated with low SES and black racial/ethnic status. Our findings inform fundamental cause theory by illustrating how disparities in distinct stages of the uptake of new treatments may contribute to reproducing existing health disparities-and, in this case of adolescent HPV vaccination, may maintain future disparities in cervical cancer among adult populations. Copyright © 2012 Elsevier Ltd. All rights reserved.

Burn prevention in Zambia: a targeted epidemiological approach.

PubMed

Heard, Jason P; Latenser, Barbara A; Liao, Junlin

2013-01-01

The aim of this study is to assess primary burn prevention knowledge in a rural Zambian population that is disproportionately burdened by burn injuries. A 10-question survey was completed by youths, and a 15-question survey was completed by adults. The survey was available in both English and Nyanja. The surveys were designed to test their knowledge in common causes, first aid, and emergency measures regarding burn injuries. Logistic regression analysis was used to explore relationships between burn knowledge, age, school, and socioeconomic variables. A burn prevention coloring book, based on previous local epidemiological data, was also distributed to 800 school age youths. Five hundred fifty youths and 39 adults completed the survey. The most significant results show knowledge deficits in common causes of burns, first aid treatment of a burn injury, and what to do in the event of clothing catching fire. Younger children were more likely to do worse than older children. The adults performed better than the youths, but still lack fundamental burn prevention and treatment knowledge. Primary burn prevention data from the youths and adults surveyed demonstrate a clear need for burn prevention and treatment education in this population. In a country where effective and sustainable burn care is lacking, burn prevention may be a better investment to reduce burn injury than large investments in healthcare resources.

Fundamental ecology is fundamental.

PubMed

Courchamp, Franck; Dunne, Jennifer A; Le Maho, Yvon; May, Robert M; Thébaud, Christophe; Hochberg, Michael E

2015-01-01

The primary reasons for conducting fundamental research are satisfying curiosity, acquiring knowledge, and achieving understanding. Here we develop why we believe it is essential to promote basic ecological research, despite increased impetus for ecologists to conduct and present their research in the light of potential applications. This includes the understanding of our environment, for intellectual, economical, social, and political reasons, and as a major source of innovation. We contend that we should focus less on short-term, objective-driven research and more on creativity and exploratory analyses, quantitatively estimate the benefits of fundamental research for society, and better explain the nature and importance of fundamental ecology to students, politicians, decision makers, and the general public. Our perspective and underlying arguments should also apply to evolutionary biology and to many of the other biological and physical sciences. Copyright © 2014 The Authors. Published by Elsevier Ltd.. All rights reserved.

A review of fundamental principles for animal models of DOHaD research: an Australian perspective.

PubMed

Dickinson, H; Moss, T J; Gatford, K L; Moritz, K M; Akison, L; Fullston, T; Hryciw, D H; Maloney, C A; Morris, M J; Wooldridge, A L; Schjenken, J E; Robertson, S A; Waddell, B J; Mark, P J; Wyrwoll, C S; Ellery, S J; Thornburg, K L; Muhlhausler, B S; Morrison, J L

2016-10-01

Epidemiology formed the basis of 'the Barker hypothesis', the concept of 'developmental programming' and today's discipline of the Developmental Origins of Health and Disease (DOHaD). Animal experimentation provided proof of the underlying concepts, and continues to generate knowledge of underlying mechanisms. Interventions in humans, based on DOHaD principles, will be informed by experiments in animals. As knowledge in this discipline has accumulated, from studies of humans and other animals, the complexity of interactions between genome, environment and epigenetics, has been revealed. The vast nature of programming stimuli and breadth of effects is becoming known. As a result of our accumulating knowledge we now appreciate the impact of many variables that contribute to programmed outcomes. To guide further animal research in this field, the Australia and New Zealand DOHaD society (ANZ DOHaD) Animals Models of DOHaD Research Working Group convened at the 2nd Annual ANZ DOHaD Congress in Melbourne, Australia in April 2015. This review summarizes the contributions of animal research to the understanding of DOHaD, and makes recommendations for the design and conduct of animal experiments to maximize relevance, reproducibility and translation of knowledge into improving health and well-being.

Effects of nursing process-based simulation for maternal child emergency nursing care on knowledge, attitude, and skills in clinical nurses.

PubMed

Kim, Sunghee; Shin, Gisoo

2016-02-01

Since previous studies on simulation-based education have been focused on fundamental nursing skills for nursing students in South Korea, there is little research available that focuses on clinical nurses in simulation-based training. Further, there is a paucity of research literature related to the integration of the nursing process into simulation training particularly in the emergency nursing care of high-risk maternal and neonatal patients. The purpose of this study was to identify the effects of nursing process-based simulation on knowledge, attitudes, and skills for maternal and child emergency nursing care in clinical nurses in South Korea. Data were collected from 49 nurses, 25 in the experimental group and 24 in the control group, from August 13 to 14, 2013. This study was an equivalent control group pre- and post-test experimental design to compare the differences in knowledge, attitudes, and skills for maternal and child emergency nursing care between the experimental group and the control group. The experimental group was trained by the nursing process-based simulation training program, while the control group received traditional methods of training for maternal and child emergency nursing care. The experimental group was more likely to improve knowledge, attitudes, and skills required for clinical judgment about maternal and child emergency nursing care than the control group. Among five stages of nursing process in simulation, the experimental group was more likely to improve clinical skills required for nursing diagnosis and nursing evaluation than the control group. These results will provide valuable information on developing nursing process-based simulation training to improve clinical competency in nurses. Further research should be conducted to verify the effectiveness of nursing process-based simulation with more diverse nurse groups on more diverse subjects in the future. Copyright © 2015 Elsevier Ltd. All rights reserved.

The idea of the library in the twenty-first century*

PubMed Central

Matheson, Nina W.

2012-01-01

The fundamental idea of the library must change. The nineteenth-century idea of the library as the embalming of dead genius and the twentieth-century idea of the library as the repository for secondhand knowledge must give way to the idea of the library as the owner and the librarian as the manager of first-hand knowledge. In the coming era of knowledge capitalism, those individuals and organizations will flourish who are able to apply knowledge to create knowledge and to organize it to produce knowledge. The roles of present-day librarians and libraries will begin to differentiate sharply over the next decade. Some must seize the opportunity to participate in the transformation of libraries into online knowledge servers. PMID:23509431

Transverse mode instabilities in burst operation of high-power fiber laser systems

NASA Astrophysics Data System (ADS)

Jauregui, Cesar; Stihler, Christoph; Tünnermann, Andreas; Limpert, Jens

2018-02-01

We propose, to the best of our knowledge, the first mitigation strategy for TMI based on controlling the phase shift between the thermally-induced index grating and the modal intensity pattern. In particular, in this work we present a study of transverse mode instabilities in burst operation in a high-power fiber laser system. It is shown that, with a careful choice of the parameters, this operation regime can potentially lead to the mitigation of TMI by forcing an energy transfer from the higher-order-modes into the fundamental mode during the burst.

Computing in Hydraulic Engineering Education

NASA Astrophysics Data System (ADS)

Duan, J. G.

2011-12-01

Civil engineers, pioneers of our civilization, are rarely perceived as leaders and innovators in modern society because of retardations in technology innovation. This crisis has resulted in the decline of the prestige of civil engineering profession, reduction of federal funding on deteriorating infrastructures, and problems with attracting the most talented high-school students. Infusion of cutting-edge computer technology and stimulating creativity and innovation therefore are the critical challenge to civil engineering education. To better prepare our graduates to innovate, this paper discussed the adaption of problem-based collaborative learning technique and integration of civil engineering computing into a traditional civil engineering curriculum. Three interconnected courses: Open Channel Flow, Computational Hydraulics, and Sedimentation Engineering, were developed with emphasis on computational simulations. In Open Channel flow, the focuses are principles of free surface flow and the application of computational models. This prepares students to the 2nd course, Computational Hydraulics, that introduce the fundamental principles of computational hydraulics, including finite difference and finite element methods. This course complements the Open Channel Flow class to provide students with in-depth understandings of computational methods. The 3rd course, Sedimentation Engineering, covers the fundamentals of sediment transport and river engineering, so students can apply the knowledge and programming skills gained from previous courses to develop computational models for simulating sediment transport. These courses effectively equipped students with important skills and knowledge to complete thesis and dissertation research.

Self-Centered Management Skills and Knowledge Appropriation by Students in High Schools and Private Secondary Schools of the City of Maroua

ERIC Educational Resources Information Center

Oyono, Tadjuidje Michel

2016-01-01

Knowledge in its process of appropriation necessitates on the part of the learner, the mobilization of an efficient management strategy of adapted competencies. The present article in its problematic presents the theoretical perspective of Desaunay (1985) which estimates that three fundamental competences (relational, technical and affective) have…

Overcoming Relativism and Absolutism: Dewey's Ideals of Truth and Meaning in Philosophy for Children

ERIC Educational Resources Information Center

Bleazby, Jennifer

2011-01-01

Different notions of truth imply and encourage different ideals of thinking, knowledge, meaning, and learning. Thus, these concepts have fundamental importance for educational theory and practice. In this paper, I intend to draw out and clarify the notions of truth, knowledge and meaning that are implied by P4C's pedagogical ideals. There is some…

On the Biological Plausibility of Grandmother Cells: Implications for Neural Network Theories in Psychology and Neuroscience

ERIC Educational Resources Information Center

Bowers, Jeffrey S.

2009-01-01

A fundamental claim associated with parallel distributed processing (PDP) theories of cognition is that knowledge is coded in a distributed manner in mind and brain. This approach rejects the claim that knowledge is coded in a localist fashion, with words, objects, and simple concepts (e.g. "dog"), that is, coded with their own dedicated…

From Classification to "Knowledge Organization": Dorking Revisited or "Past is Prelude." FID Occasional Paper No. 14.

ERIC Educational Resources Information Center

Gilchrist, Alan, Ed.

This set of papers offers insights into some of the major developments in the field of classification and knowledge organization, and highlights many of the fundamental changes in views and theories which have taken place during the last 40 years. This document begins with a series of reminiscences from former delegates of the first International…

Reading for Meaning: The Foundational Knowledge Every Teacher of Science Should Have

ERIC Educational Resources Information Center

Patterson, Alexis; Roman, Diego; Friend, Michelle; Osborne, Jonathan; Donovan, Brian

2018-01-01

Reading is fundamental to science and not an adjunct to its practice. In other words, understanding the meaning of the various forms of written discourse employed in the creation, discussion, and communication of scientific knowledge is inherent to how science works. The language used in science, however, sets up a barrier, that in order to be…

How to Construct More Accurate Student Models: Comparing and Optimizing Knowledge Tracing and Performance Factor Analysis

ERIC Educational Resources Information Center

Gong, Yue; Beck, Joseph E.; Heffernan, Neil T.

2011-01-01

Student modeling is a fundamental concept applicable to a variety of intelligent tutoring systems (ITS). However, there is not a lot of practical guidance on how to construct and train such models. This paper compares two approaches for student modeling, Knowledge Tracing (KT) and Performance Factors Analysis (PFA), by evaluating their predictive…

A blended-learning programme regarding professional ethics in physiotherapy students.

PubMed

Aguilar-Rodríguez, Marta; Marques-Sule, Elena; Serra-Añó, Pilar; Espí-López, Gemma Victoria; Dueñas-Moscardó, Lirios; Pérez-Alenda, Sofía

2018-01-01

In the university context, assessing students' attitude, knowledge and opinions when applying an innovative methodological approach to teach professional ethics becomes fundamental to know if the used approach is enough motivating for students. To assess the effect of a blended-learning model, based on professional ethics and related to clinical practices, on physiotherapy students' attitude, knowledge and opinions towards learning professional ethics. Research design and participants: A simple-blind clinical trial was performed (NLM identifier NCT03241693) (control group, n = 64; experimental group, n = 65). Both groups followed clinical practices for 8 months. Control group performed a public exposition of a clinical case about professional ethics. By contrast, an 8-month blended-learning programme regarding professional ethics was worked out for experimental group. An online syllabus and online activities were elaborated, while face-to-face active participation techniques were performed to discuss ethical issues. Students' attitudes, knowledge and opinions towards learning professional ethics were assessed. Ethical considerations: The study was approved by the University Ethic Committee of Human Research and followed the ethical principles according to the Declaration of Helsinki. After the programme, attitudes and knowledge towards learning professional ethics of experimental group students significantly improved, while no differences were observed in control group. Moreover, opinions reported an adequate extension of themes and temporization, importance of clinical practices and interest of topics. Case study method and role playing were considered as the most helpful techniques. The blended-learning programme proposed, based on professional ethics and related to clinical practices, improves physiotherapy students' attitudes, knowledge and opinions towards learning professional ethics.

Supramolecular chemistry and chemical warfare agents: from fundamentals of recognition to catalysis and sensing.

PubMed

Sambrook, M R; Notman, S

2013-12-21

Supramolecular chemistry presents many possible avenues for the mitigation of the effects of chemical warfare agents (CWAs), including sensing, catalysis and sequestration. To-date, efforts in this field both to study fundamental interactions between CWAs and to design and exploit host systems remain sporadic. In this tutorial review the non-covalent recognition of CWAs is considered from first principles, including taking inspiration from enzymatic systems, and gaps in fundamental knowledge are indicated. Examples of synthetic systems developed for the recognition of CWAs are discussed with a focus on the supramolecular complexation behaviour and non-covalent approaches rather than on the proposed applications.

The Essential Role for Laboratory Studies in Atmospheric Chemistry

DOE Office of Scientific and Technical Information (OSTI.GOV)

Burkholder, James B.; Abbatt, Jonathan P. D.; Barnes, Ian

Laboratory studies of atmospheric chemistry characterize the nature of atmospherically relevant processes down to the molecular level, providing fundamental information used to assess how human activities drive environmental phenomena such as climate change, urban air pollution, ecosystem health, indoor air quality, and stratospheric ozone depletion. Laboratory studies have a central role in addressing the incomplete fundamental knowledge of atmospheric chemistry. This paper highlights the evolving science needs for this community and emphasizes how our knowledge is far from complete, hindering our ability to predict the future state of our atmosphere and to respond to emerging global environmental change issues. Finally,more » laboratory studies provide rich opportunities to expand our understanding of the atmosphere via collaborative research with the modeling and field measurement communities, and with neighboring disciplines.« less

Obstetric skills drills: evaluation of teaching methods.

PubMed

Birch, L; Jones, N; Doyle, P M; Green, P; McLaughlin, A; Champney, C; Williams, D; Gibbon, K; Taylor, K

2007-11-01

To determine the most effective method of delivering training to staff on the management of an obstetric emergency. The research was conducted in a District General Hospital in the UK, delivering approximately 3500 women per year. Thirty-six staff, comprising of junior and senior medical and midwifery staff were included as research subjects. Each of the staff members were put into one of six multi-professional teams. Effectively, this gave six teams, each comprising of six members. Three teaching methods were employed. Lecture based teaching (LBT), simulation based teaching (SBT) or a combination of these two (LAS). Each team of staff were randomly allocated to undertake a full day of training in the management of Post Partum Haemorrhage utilising one of these three teaching methods. Team knowledge and performance were assessed pre-training, post training and at three months later. In addition to this assessment of knowledge and performance, qualitative semi-structured interviews were carried out with 50% of the original cohort one year after the training, to explore anxiety, confidence, communication, knowledge retention, enjoyment and transferable skills. All teams improved in their performance and knowledge. The teams taught using simulation only (SBT) were the only group to demonstrate sustained improvement in clinical management of the case, confidence, communication skills and knowledge. However, the study did not have enough power to reach statistical significance. The SBT group reported transferable skills and less anxiety in subsequent emergencies. SBT and LAS reported improved multidisciplinary communication. Although tiring, the SBT was enjoyed the most. Obstetrics is a high risk speciality, in which emergencies are to some extent, inevitable. Training staff to manage these emergencies is a fundamental principal of risk management. Traditional risk management strategies based on incident reporting and event analysis are reactive and not always effective. Simulation based training is an appropriate proactive approach to reducing errors and risk in obstetrics, improving teamwork and communication, whilst giving the student a multiplicity of transferable skills to improve their performance.

A Novel Platform for Evaluating the Environmental Impacts on Bacterial Cellulose Production.

PubMed

Basu, Anindya; Vadanan, Sundaravadanam Vishnu; Lim, Sierin

2018-04-10

Bacterial cellulose (BC) is a biocompatible material with versatile applications. However, its large-scale production is challenged by the limited biological knowledge of the bacteria. The advent of synthetic biology has lead the way to the development of BC producing microbes as a novel chassis. Hence, investigation on optimal growth conditions for BC production and understanding of the fundamental biological processes are imperative. In this study, we report a novel analytical platform that can be used for studying the biology and optimizing growth conditions of cellulose producing bacteria. The platform is based on surface growth pattern of the organism and allows us to confirm that cellulose fibrils produced by the bacteria play a pivotal role towards their chemotaxis. The platform efficiently determines the impacts of different growth conditions on cellulose production and is translatable to static culture conditions. The analytical platform provides a means for fundamental biological studies of bacteria chemotaxis as well as systematic approach towards rational design and development of scalable bioprocessing strategies for industrial production of bacterial cellulose.

Sigmund Freud-early network theories of the brain.

PubMed

Surbeck, Werner; Killeen, Tim; Vetter, Johannes; Hildebrandt, Gerhard

2018-06-01

Since the early days of modern neuroscience, psychological models of brain function have been a key component in the development of new knowledge. These models aim to provide a framework that allows the integration of discoveries derived from the fundamental disciplines of neuroscience, including anatomy and physiology, as well as clinical neurology and psychiatry. During the initial stages of his career, Sigmund Freud (1856-1939), became actively involved in these nascent fields with a burgeoning interest in functional neuroanatomy. In contrast to his contemporaries, Freud was convinced that cognition could not be localised to separate modules and that the brain processes cognition not in a merely serial manner but in a parallel and dynamic fashion-anticipating fundamental aspects of current network theories of brain function. This article aims to shed light on Freud's seminal, yet oft-overlooked, early work on functional neuroanatomy and his reasons for finally abandoning the conventional neuroscientific "brain-based" reference frame in order to conceptualise the mind from a purely psychological perspective.

Research progress on organic-inorganic halide perovskite materials and solar cells

NASA Astrophysics Data System (ADS)

Ono, Luis K.; Qi, Yabing

2018-03-01

Owing to the intensive research efforts across the world since 2009, perovskite solar cell power conversion efficiencies (PCEs) are now comparable or even better than several other photovoltaic (PV) technologies. In this topical review article, we review recent progress in the field of organic-inorganic halide perovskite materials and solar cells. We associate these achievements with the fundamental knowledge gained in the perovskite research. The major recent advances in the fundamental perovskite material and solar cell research are highlighted, including the current efforts in visualizing the dynamical processes (in operando) taking place within a perovskite solar cell under operating conditions. We also discuss the existing technological challenges. Based on a survey of recently published works, we point out that to move the perovskite PV technology forward towards the next step of commercialization, what perovskite PV technology need the most in the coming next few years is not only further PCE enhancements, but also up-scaling, stability, and lead-toxicity.

The Case for Natural History

NASA Astrophysics Data System (ADS)

King, Heather; Achiam, Marianne

2017-03-01

Fundamental knowledge of natural history is lacking in many western societies, as demonstrated by its absence in school science curricula. And yet, to meet local and global challenges such as environmental degradation, biodiversity loss and climate change, we need to better understand the living and non-living parts of the natural world. Many have argued passionately for an increased understanding of natural history; others have developed successful pedagogical programmes for applying knowledge of natural history in environmental initiatives. In joining wider calls, we choose here to focus on the educational value afforded by understanding the epistemological bases of natural history and its particular forms of reasoning. We also briefly discuss the ways in which an education in natural history provides the foundation for environmental and social justice efforts that directly affect the lives of young people and their communities. We end by highlighting the ease by which natural history may be incorporated in learning opportunities both in and outside of the classroom.

Knowledge-making distinctions in synthetic biology.

PubMed

O'Malley, Maureen A; Powell, Alexander; Davies, Jonathan F; Calvert, Jane

2008-01-01

Synthetic biology is an increasingly high-profile area of research that can be understood as encompassing three broad approaches towards the synthesis of living systems: DNA-based device construction, genome-driven cell engineering and protocell creation. Each approach is characterized by different aims, methods and constructs, in addition to a range of positions on intellectual property and regulatory regimes. We identify subtle but important differences between the schools in relation to their treatments of genetic determinism, cellular context and complexity. These distinctions tie into two broader issues that define synthetic biology: the relationships between biology and engineering, and between synthesis and analysis. These themes also illuminate synthetic biology's connections to genetic and other forms of biological engineering, as well as to systems biology. We suggest that all these knowledge-making distinctions in synthetic biology raise fundamental questions about the nature of biological investigation and its relationship to the construction of biological components and systems. (c) 2007 Wiley Periodicals, Inc.

Impact of a Required Pharmaceutical Calculations Course on Mathematics Ability and Knowledge Retention

PubMed Central

Buring, Shauna M.; Papas, Elizabeth

2013-01-01

Objective. To assess doctor of pharmacy (PharmD) students’ mathematics ability by content area before and after completing a required pharmaceutical calculations course and to analyze changes in scores. Methods. A mathematics skills assessment was administered to 2 cohorts of pharmacy students (class of 2013 and 2014) before and after completing a pharmaceutical calculations course. The posttest was administered to the second cohort 6 months after completing the course to assess knowledge retention. Results. Both cohorts performed significantly better on the posttest (cohort 1, 13% higher scores; cohort 2, 15.9% higher scores). Significant improvement on posttest scores was observed in 6 of the 10 content areas for cohorts 1 and 2. Both cohorts scored lower in percentage calculations on the posttest than on the pretest. Conclusions. A required, 1-credit-hour pharmaceutical calculations course improved PharmD students’ overall ability to perform fundamental and application-based calculations. PMID:23966727

Impact of a required pharmaceutical calculations course on mathematics ability and knowledge retention.

PubMed

Hegener, Michael A; Buring, Shauna M; Papas, Elizabeth

2013-08-12

To assess doctor of pharmacy (PharmD) students' mathematics ability by content area before and after completing a required pharmaceutical calculations course and to analyze changes in scores. A mathematics skills assessment was administered to 2 cohorts of pharmacy students (class of 2013 and 2014) before and after completing a pharmaceutical calculations course. The posttest was administered to the second cohort 6 months after completing the course to assess knowledge retention. Both cohorts performed significantly better on the posttest (cohort 1, 13% higher scores; cohort 2, 15.9% higher scores). Significant improvement on posttest scores was observed in 6 of the 10 content areas for cohorts 1 and 2. Both cohorts scored lower in percentage calculations on the posttest than on the pretest. A required, 1-credit-hour pharmaceutical calculations course improved PharmD students' overall ability to perform fundamental and application-based calculations.

Systemic Risk Analysis on Reconstructed Economic and Financial Networks

PubMed Central

Cimini, Giulio; Squartini, Tiziano; Garlaschelli, Diego; Gabrielli, Andrea

2015-01-01

We address a fundamental problem that is systematically encountered when modeling real-world complex systems of societal relevance: the limitedness of the information available. In the case of economic and financial networks, privacy issues severely limit the information that can be accessed and, as a consequence, the possibility of correctly estimating the resilience of these systems to events such as financial shocks, crises and cascade failures. Here we present an innovative method to reconstruct the structure of such partially-accessible systems, based on the knowledge of intrinsic node-specific properties and of the number of connections of only a limited subset of nodes. This information is used to calibrate an inference procedure based on fundamental concepts derived from statistical physics, which allows to generate ensembles of directed weighted networks intended to represent the real system—so that the real network properties can be estimated as their average values within the ensemble. We test the method both on synthetic and empirical networks, focusing on the properties that are commonly used to measure systemic risk. Indeed, the method shows a remarkable robustness with respect to the limitedness of the information available, thus representing a valuable tool for gaining insights on privacy-protected economic and financial systems. PMID:26507849

Earth Science Enterprise Technology Strategy

NASA Technical Reports Server (NTRS)

1999-01-01

NASA's Earth Science Enterprise (ESE) is dedicated to understanding the total Earth system and the effects of natural and human-induced changes on the global environment. The goals of ESE are: (1) Expand scientific knowledge of the Earth system using NASA's unique vantage points of space, aircraft, and in situ platforms; (2) Disseminate information about the Earth system; and (3) Enable the productive use of ESE science and technology in the public and private sectors. ESE has embraced the NASA Administrator's better, faster, cheaper paradigm for Earth observing missions. We are committed to launch the next generation of Earth Observing System (EOS) missions at a substantially lower cost than the EOS first series. Strategic investment in advanced instrument, spacecraft, and information system technologies is essential to accomplishing ESE's research goals in the coming decades. Advanced technology will play a major role in shaping the ESE fundamental and applied research program of the future. ESE has established an Earth science technology development program with the following objectives: (1) To accomplish ESE space-based and land-based program elements effectively and efficiently; and (2) To enable ESE's fundamental and applied research programs goals as stated in the NASA Strategic Plan.

Quantitative mass spectrometry: an overview

NASA Astrophysics Data System (ADS)

Urban, Pawel L.

2016-10-01

Mass spectrometry (MS) is a mainstream chemical analysis technique in the twenty-first century. It has contributed to numerous discoveries in chemistry, physics and biochemistry. Hundreds of research laboratories scattered all over the world use MS every day to investigate fundamental phenomena on the molecular level. MS is also widely used by industry-especially in drug discovery, quality control and food safety protocols. In some cases, mass spectrometers are indispensable and irreplaceable by any other metrological tools. The uniqueness of MS is due to the fact that it enables direct identification of molecules based on the mass-to-charge ratios as well as fragmentation patterns. Thus, for several decades now, MS has been used in qualitative chemical analysis. To address the pressing need for quantitative molecular measurements, a number of laboratories focused on technological and methodological improvements that could render MS a fully quantitative metrological platform. In this theme issue, the experts working for some of those laboratories share their knowledge and enthusiasm about quantitative MS. I hope this theme issue will benefit readers, and foster fundamental and applied research based on quantitative MS measurements. This article is part of the themed issue 'Quantitative mass spectrometry'.

Systemic Risk Analysis on Reconstructed Economic and Financial Networks

NASA Astrophysics Data System (ADS)

Cimini, Giulio; Squartini, Tiziano; Garlaschelli, Diego; Gabrielli, Andrea

2015-10-01

We address a fundamental problem that is systematically encountered when modeling real-world complex systems of societal relevance: the limitedness of the information available. In the case of economic and financial networks, privacy issues severely limit the information that can be accessed and, as a consequence, the possibility of correctly estimating the resilience of these systems to events such as financial shocks, crises and cascade failures. Here we present an innovative method to reconstruct the structure of such partially-accessible systems, based on the knowledge of intrinsic node-specific properties and of the number of connections of only a limited subset of nodes. This information is used to calibrate an inference procedure based on fundamental concepts derived from statistical physics, which allows to generate ensembles of directed weighted networks intended to represent the real system—so that the real network properties can be estimated as their average values within the ensemble. We test the method both on synthetic and empirical networks, focusing on the properties that are commonly used to measure systemic risk. Indeed, the method shows a remarkable robustness with respect to the limitedness of the information available, thus representing a valuable tool for gaining insights on privacy-protected economic and financial systems.

Integrative endeavor for renaissance in Ayurveda

PubMed Central

Raut, Ashwinikumar A.

2011-01-01

Currently western medicine has assumed the central position in mainstream global healthcare. Openness to learn from contemporary disciplines of basic sciences, application of modern technology and further adoption of the evidence-based approach has helped western medicine gain its currently acknowledged position as mainstream modern medicine. Modern medicine has further developed forms of integrative medicine by developing interfaces with other systems of medicine, including traditional, complementary and alternative medicine. However, these developments do not seem to address all the problems facing global health care caused by overemphasis on pharmaco-therapeutic drug developments. On the other hand, Ayurveda which is founded on genuine fundamentals, has the longest uninterrupted tradition of healthcare practice, and its holistic approach to healthcare management emphasizes disease prevention and health promotion; if it opens up to incorporate emerging new knowledge into mainstream Ayurveda, and maintains fidelity to Ayurveda fundamentals, it will certainly provide a broad-based opportunity to address the majority of the problems that have emerged from global healthcare requirements. To bring these solutions to bear, however, it will be necessary to progress from the present “utilitarian ethos” to a “unifying ethos” for realization of medical integration. PMID:21731380

Fundamentals and clinical perspective of urethral sphincter instability as a contributing factor in patients with lower urinary tract dysfunction--ICI-RS 2014.

PubMed

Kirschner-Hermanns, Ruth; Anding, Ralf; Rosier, Peter; Birder, Lori; Andersson, Karl Erik; Djurhuus, Jens Christian

2016-02-01

Urethral pathophysiology is often neglected in discussions of bladder dysfunction. It has been debated whether "urethral sphincter instability," referred to based on observed "urethral pressure variations," is an important aspect of overactive bladder syndrome (OAB). The purpose of this report is to summarize current urethral pathophysiology evidence and outline directions for future research based on a literature review and discussions during the ICI-RS meeting in Bristol in 2014. Urethral pathophysiology with a focus on urethral pressure variation (UPV) was presented and discussed in a multidisciplinary think tank session at the ICI_R meeting in Bristol 2014. This think tank session was based on collaboration between physicians and basic science researchers. Experimental animal studies or studies performed in clinical series (predominantly symptomatic women) provided insights into UPV, but the findings were inconsistent and incomplete. However, UPV is certainly associated with lower urinary tract symptoms (likely OAB), and thus, future research on this topic is relevant. Future research based on adequately defined clinical (and urodynamic) parameters with precisely defined patient groups might shed better light on the cause of OAB symptoms. Further fundamental investigation of urethral epithelial-neural interactions via the release of mediators should enhance our knowledge and improve the management of patients with OAB. © 2016 The Authors. Neurourology and Urodynamics published by Wiley Periodicals, Inc.

Gender differences in children's voice use in a day care environment.

PubMed

Nygren, Mariana; Tyboni, Mikaela; Lindström, Fredric; McAllister, Anita; van Doorn, Jan

2012-11-01

The prevalence of dysphonia is higher in boys than in girls before puberty. This could be because of the differences in boys' and girls' voice use. Previous research on gender differences in prepubescent children's voice parameters has been contradictory. Most studies have focused on examining fundamental frequency. The purpose of this study was to investigate voice use in boys and girls in a day care environment based on the voice parameters fundamental frequency (Hz), vocal intensity (dB SPL), and phonation time (%) and to ascertain whether there were any significant gender differences. Prospective comparative design. The study was conducted in a day care environment where 30 children (17 boys and 13 girls aged 4-5 years) participated. The participants' voices were measured continuously for 4 hours with a voice accumulator that registered fundamental frequency, vocal intensity level, phonation time, and background noise. Mean (standard deviation) fundamental frequency was 310 (22) and 321 (16) Hz, vocal intensity was 93 (4) and 91 (3) dB SPL, and phonation time was 7.7 (2.0)% and 7.6 (2.5)% for boys and girls, respectively. No differences between genders were statistically significant. The finding of no statistically significant gender differences for measurements of voice parameters in a group of children aged 4-5 years in a day care environment is an important finding that contributes to increased knowledge about young boys' and girls' voice use. Copyright © 2012 The Voice Foundation. Published by Mosby, Inc. All rights reserved.

Fundamentals of Structural Geology

NASA Astrophysics Data System (ADS)

Pollard, David D.; Fletcher, Raymond C.

2005-09-01

Fundamentals of Structural Geology provides a new framework for the investigation of geological structures by integrating field mapping and mechanical analysis. Assuming a basic knowledge of physical geology, introductory calculus and physics, it emphasizes the observational data, modern mapping technology, principles of continuum mechanics, and the mathematical and computational skills, necessary to quantitatively map, describe, model, and explain deformation in Earth's lithosphere. By starting from the fundamental conservation laws of mass and momentum, the constitutive laws of material behavior, and the kinematic relationships for strain and rate of deformation, the authors demonstrate the relevance of solid and fluid mechanics to structural geology. This book offers a modern quantitative approach to structural geology for advanced students and researchers in structural geology and tectonics. It is supported by a website hosting images from the book, additional colour images, student exercises and MATLAB scripts. Solutions to the exercises are available to instructors. The book integrates field mapping using modern technology with the analysis of structures based on a complete mechanics MATLAB is used to visualize physical fields and analytical results and MATLAB scripts can be downloaded from the website to recreate textbook graphics and enable students to explore their choice of parameters and boundary conditions The supplementary website hosts color images of outcrop photographs used in the text, supplementary color images, and images of textbook figures for classroom presentations The textbook website also includes student exercises designed to instill the fundamental relationships, and to encourage the visualization of the evolution of geological structures; solutions are available to instructors

Lipid Storage Diseases

MedlinePlus

... Neurological Disorders and Stroke (NINDS) is to seek fundamental knowledge about the brain and nervous system and ... some of the major challenges in the diagnosis, management, and therapy of rare diseases, including the lipid ...

Investigation of outside visual cues required for low speed and hover

NASA Technical Reports Server (NTRS)

Hoh, R. H.

1985-01-01

Knowledge of the visual cues required in the performance of stabilized hover in VTOL aircraft is a prerequisite for the development of both cockpit displays and ground-based simulation systems. Attention is presently given to the viability of experimental test flight techniques as the bases for the identification of essential external cues in aggressive and precise low speed and hovering tasks. The analysis and flight test program conducted employed a helicopter and a pilot wearing lenses that could be electronically fogged, where the primary variables were field-of-view, large object 'macrotexture', and fine detail 'microtexture', in six different fields-of-view. Fundamental metrics are proposed for the quantification of the visual field, to allow comparisons between tests, simulations, and aircraft displays.

Luminescence Dating of Martian Polar Deposits: Concepts and Preliminary Measurements Using Martian Soil Analogs

NASA Astrophysics Data System (ADS)

Lepper, K.; Kuhns, C. K.; McKeever, S. W. S.; Sears, D. W. G.

2000-08-01

Martian polar deposits have the potential to reveal a wealth of information about the evolution of Mars' climate and surface environment. However, as pointed out by Clifford et al. in the summary of the First International Conference on Mars Polar Science and Exploration, 'The single greatest obstacle to unlocking and interpreting the geologic and climatic record preserved at the [martian] poles is the need for absolute dating.' At that same conference Lepper and McKeever proposed development of luminescence dating as a remote in-situ technique for absolute dating of silicate mineral grains incorporated in polar deposits. Clifford et al. have also acknowledged that luminescence dating is more practical from cost, engineering, and logistical perspectives than other isotope-based methods proposed for in-situ dating on Mars. We report here the results of ongoing experiments with terrestrial analogs of martian surface materials to establish a broad fundamental knowledge base from which robust dating procedures for robotic missions may be developed. This broad knowledge base will also be critical in determining the engineering requirements of remote in-situ luminescence dating equipment intended for use on Mars. Additional information can be found in the original extended abstract.

DataHub: Science data management in support of interactive exploratory analysis

NASA Technical Reports Server (NTRS)

Handley, Thomas H., Jr.; Rubin, Mark R.

1993-01-01

The DataHub addresses four areas of significant needs: scientific visualization and analysis; science data management; interactions in a distributed, heterogeneous environment; and knowledge-based assistance for these functions. The fundamental innovation embedded within the DataHub is the integration of three technologies, viz. knowledge-based expert systems, science visualization, and science data management. This integration is based on a concept called the DataHub. With the DataHub concept, science investigators are able to apply a more complete solution to all nodes of a distributed system. Both computational nodes and interactives nodes are able to effectively and efficiently use the data services (access, retrieval, update, etc), in a distributed, interdisciplinary information system in a uniform and standard way. This allows the science investigators to concentrate on their scientific endeavors, rather than to involve themselves in the intricate technical details of the systems and tools required to accomplish their work. Thus, science investigators need not be programmers. The emphasis on the definition and prototyping of system elements with sufficient detail to enable data analysis and interpretation leading to information. The DataHub includes all the required end-to-end components and interfaces to demonstrate the complete concept.

DataHub - Science data management in support of interactive exploratory analysis

NASA Technical Reports Server (NTRS)

Handley, Thomas H., Jr.; Rubin, Mark R.

1993-01-01

DataHub addresses four areas of significant need: scientific visualization and analysis; science data management; interactions in a distributed, heterogeneous environment; and knowledge-based assistance for these functions. The fundamental innovation embedded within the DataHub is the integration of three technologies, viz. knowledge-based expert systems, science visualization, and science data management. This integration is based on a concept called the DataHub. With the DataHub concept, science investigators are able to apply a more complete solution to all nodes of a distributed system. Both computational nodes and interactive nodes are able to effectively and efficiently use the data services (access, retrieval, update, etc.) in a distributed, interdisciplinary information system in a uniform and standard way. This allows the science investigators to concentrate on their scientific endeavors, rather than to involve themselves in the intricate technical details of the systems and tools required to accomplish their work. Thus, science investigators need not be programmers. The emphasis is on the definition and prototyping of system elements with sufficient detail to enable data analysis and interpretation leading to information. The DataHub includes all the required end-to-end components and interfaces to demonstrate the complete concept.

Intersection of argumentation and the use of multiple representations in the context of socioscientific issues

NASA Astrophysics Data System (ADS)

Namdar, Bahadir; Shen, Ji

2016-05-01

Using multiple representations and argumentation are two fundamental processes in science. With the advancements of information communication technologies, these two processes are blended more so than ever before. However, little is known about how these two processes interact with each other in student learning. Hence, we conducted a design-based study in order to distill the relationship between these two processes. Specifically, we designed a learning unit on nuclear energy and implemented it with a group of preservice middle school teachers. The participants used a web-based knowledge organization platform that incorporated three representational modes: textual, concept map, and pictorial. The participants organized their knowledge on nuclear energy by searching, sorting, clustering information through the use of these representational modes and argued about the nuclear energy issue. We found that the use of multiple representations and argumentation interacted with each other in a complex way. Based on our findings, we argue that the complexity can be unfolded in two aspects: (a) the use of multiple representations mediates argumentation in different forms and for different purposes; (b) the type of argumentation that leads to refinement of the use of multiple representations is often non-mediated and drawn from personal experience.

Fundamental results from microgravity cell experiments with possible commericial applications

NASA Technical Reports Server (NTRS)

Winget, Charles M.; Fast, Thomas N.; Hinds, Williams E.; Schaefer, R. L.; Callahan, Paul X.

1989-01-01

Some of the major milestones are presented for studies in cell biology that were conducted by the Soviet Union and the United States in the upper layers of the atmosphere and in outer space for more than thirty-five years. The goals have changed as new knowledge is acquired and the priorities for the use of microgravity have shifted toward basic research and commercial applications. Certain details concerning the impact of microgravity on cell systems is presented. However, it needs to be emphasized that in planning and conducting microgravity experiments, there are some important prerequisites not normally taken into account. Apart from the required background knowledge of previous microgravity and ground-based experiments, the investigator should have the understanding of the hardware as a physical unit, the complete knowledge of its operation, the range of its capabilities and the anticipation of problems that may occur. Moreover, if the production of commercial products in space is to be manifested, data obtained from previous microgravity experiments must be used to optimize the design of flight hardware.

Understanding pressurized metered dose inhaler performance.

PubMed

Ivey, James W; Vehring, Reinhard; Finlay, Warren H

2015-06-01

Deepening the current understanding of the factors governing the performance of the pressurized metered dose inhaler (pMDI) has the potential to benefit patients by providing improved drugs for current indications as well as by enabling new areas of therapy. Although a great deal of work has been conducted to this end, our knowledge of the physical mechanisms that drive pMDI performance remains incomplete. This review focuses on research into the influence of device and formulation variables on pMDI performance metrics. Literature in the areas of dose metering, atomization and aerosol evolution and deposition is covered, with an emphasis on studies of a more fundamental nature. Simple models which may be of use to those developing pMDI products are summarized. Although researchers have had good success utilizing an empirically developed knowledge base to predict pMDI performance, such knowledge may not be applicable when pursuing innovations in device or formulation technology. Developing a better understanding of the underlying mechanisms is a worthwhile investment for those working to enable the next generation of pMDI products.

A circadian rhythm in skill-based errors in aviation maintenance.

PubMed

Hobbs, Alan; Williamson, Ann; Van Dongen, Hans P A

2010-07-01

In workplaces where activity continues around the clock, human error has been observed to exhibit a circadian rhythm, with a characteristic peak in the early hours of the morning. Errors are commonly distinguished by the nature of the underlying cognitive failure, particularly the level of intentionality involved in the erroneous action. The Skill-Rule-Knowledge (SRK) framework of Rasmussen is used widely in the study of industrial errors and accidents. The SRK framework describes three fundamental types of error, according to whether behavior is under the control of practiced sensori-motor skill routines with minimal conscious awareness; is guided by implicit or explicit rules or expertise; or where the planning of actions requires the conscious application of domain knowledge. Up to now, examinations of circadian patterns of industrial errors have not distinguished between different types of error. Consequently, it is not clear whether all types of error exhibit the same circadian rhythm. A survey was distributed to aircraft maintenance personnel in Australia. Personnel were invited to anonymously report a safety incident and were prompted to describe, in detail, the human involvement (if any) that contributed to it. A total of 402 airline maintenance personnel reported an incident, providing 369 descriptions of human error in which the time of the incident was reported and sufficient detail was available to analyze the error. Errors were categorized using a modified version of the SRK framework, in which errors are categorized as skill-based, rule-based, or knowledge-based, or as procedure violations. An independent check confirmed that the SRK framework had been applied with sufficient consistency and reliability. Skill-based errors were the most common form of error, followed by procedure violations, rule-based errors, and knowledge-based errors. The frequency of errors was adjusted for the estimated proportion of workers present at work/each hour of the day, and the 24 h pattern of each error type was examined. Skill-based errors exhibited a significant circadian rhythm, being most prevalent in the early hours of the morning. Variation in the frequency of rule-based errors, knowledge-based errors, and procedure violations over the 24 h did not reach statistical significance. The results suggest that during the early hours of the morning, maintenance technicians are at heightened risk of "absent minded" errors involving failures to execute action plans as intended.

Analogical and category-based inference: a theoretical integration with Bayesian causal models.

PubMed

Holyoak, Keith J; Lee, Hee Seung; Lu, Hongjing

2010-11-01

A fundamental issue for theories of human induction is to specify constraints on potential inferences. For inferences based on shared category membership, an analogy, and/or a relational schema, it appears that the basic goal of induction is to make accurate and goal-relevant inferences that are sensitive to uncertainty. People can use source information at various levels of abstraction (including both specific instances and more general categories), coupled with prior causal knowledge, to build a causal model for a target situation, which in turn constrains inferences about the target. We propose a computational theory in the framework of Bayesian inference and test its predictions (parameter-free for the cases we consider) in a series of experiments in which people were asked to assess the probabilities of various causal predictions and attributions about a target on the basis of source knowledge about generative and preventive causes. The theory proved successful in accounting for systematic patterns of judgments about interrelated types of causal inferences, including evidence that analogical inferences are partially dissociable from overall mapping quality.

Apatite and sodalite based glass-bonded waste forms for immobilization of 129I and mixed halide radioactive wastes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Goel, Ashutosh; McCloy, John S.; Riley, Brian J.

The goal of the project was to utilize the knowledge accumulated by the team, in working with minerals for chloride wastes and biological apatites, toward the development of advanced waste forms for immobilizing 129I and mixed-halide wastes. Based on our knowledge, experience, and thorough literature review, we had selected two minerals with different crystal structures and potential for high chemical durability, sodalite and CaP/PbV-apatite, to form the basis of this project. The focus of the proposed effort was towards: (i) low temperature synthesis of proposed minerals (iodine containing sodalite and apatite) leading to the development of monolithic waste forms, (ii)more » development of a fundamental understanding of the atomic-scale to meso-scale mechanisms of radionuclide incorporation in them, and (iii) understanding of the mechanism of their chemical corrosion, alteration mechanism, and rates. The proposed work was divided into four broad sections. deliverables. 1. Synthesis of materials 2. Materials structural and thermal characterization 3. Design of glass compositions and synthesis glass-bonded minerals, and 4. Chemical durability testing of materials.« less

Fundamentals of pulmonary drug delivery.

PubMed

Groneberg, D A; Witt, C; Wagner, U; Chung, K F; Fischer, A

2003-04-01

Aerosol administration of peptide-based drugs plays an important role in the treatment of pulmonary and systemic diseases and the unique cellular properties of airway epithelium offers a great potential to deliver new compounds. As the relative contributions from the large airways to the alveolar space are important to the local and systemic availability, the sites and mechanism of uptake and transport of different target compounds have to be characterized. Among the different respiratory cells, the ciliated epithelial cells of the larger and smaller airways and the type I and type II pneumocytes are the key players in pulmonary drug transport. With their diverse cellular characteristics, each of these cell types displays a unique uptake possibility. Next to the knowledge of these cellular aspects, the nature of aerosolized drugs, characteristics of delivery systems and the depositional and pulmonary clearance mechanisms display major targets to optimize pulmonary drug delivery. Based on the growing knowledge on pulmonary cell biology and pathophysiology due to modern methods of molecular biology, the future characterization of pulmonary drug transport pathways can lead to new strategies in aerosol drug therapy.

Opening our eyes to Global Health; a philosophy of universal values.

PubMed

Wass, Val

2015-12-01

Globalization is advancing at a pace. As we strive to introduce 'Global Health' into clinical curricula we risk fundamental misunderstandings unless we clearly define what we aim to achieve. Clinicians must be prepared for a life time of uncertainty, change and challenge. The fluctuating world arena will undoubtedly impact on their future work in ways we cannot predict. Population migration, climate change and shifts in cultural dominance are already at play. Global health risks being translated through the eyes of Western ideology as disease-based curricula focused paternalistically on 'helping' the developing world. We must not lack humility to open eyes to learning within the context of increasingly diverse environments and patient populations. Global health is as 'local' as it is 'international'. It should be viewed, I argue, as a philosophy based on the values and expectations found within ourselves and our communities. Responding to globalization lies not only in knowledge but embraces human rights, justice and, most importantly, self-awareness. Knowledge is more easily translated into curriculum objectives. We risk letting future clinicians and their patients down if we ignore the other universal values.

Multi-gigahertz repetition rate passively modelocked fiber lasers using carbon nanotubes.

PubMed

Martinez, Amos; Yamashita, Shinji

2011-03-28

There is an increasing demand for all-fiber passively mode-locked lasers with pulse repetition rates in the order of gigahertz for their potential applications in fields such as telecommunications and metrology. However, conventional mode-locked fiber lasers typically operate at fundamental repetition rates of only a few megahertz. In this paper, we report all-fiber laser operation with fundamental repetition rates of 4.24 GHz, 9.63 GHz and 19.45 GHz. This is, to date and to the best of our knowledge, the highest fundamental repetition rate reported for an all-fiber laser. The laser operation is based on the passive modelocking of a miniature all-fiber Fabry-Pérot laser (FFPL) by a carbon nanotube (CNT) saturable absorber. The key components for such device are a very high-gain Er:Yb phosphosilicate fiber and a fiber compatible saturable absorber with very small foot print and very low losses. The laser output of the three lasers was close to transform-limited with a pulsewidth of approximately 1 ps and low noise. As a demonstration of potential future applications for this laser, we also demonstrated supercontinuum generation with a longitudinal mode-spacing of 0.08 nm by launching the laser operating at 9.63 GHz into 30 m of a highly nonlinear dispersion shifted fiber.

Pain and pain management in dermatology.

PubMed

Beiteke, Ulrike; Bigge, Stefan; Reichenberger, Christina; Gralow, Ingrid

2015-10-01

It is estimated that 23 million Germans suffer from chronic pain. A recent survey has revealed that 30 % of chronic pain patients are dissatisfied with their pain management. Furthermore, five million Germans suffer from neuropathic pain, 20 % of whom are inadequately treated. Pain is also a symptom of many dermatologic diseases, which is mostly somatic and may be classified as mild in the majority of cases. Nevertheless, research on the quality of life (QoL) has increasingly shown a marked impairment of QoL by moderate pain such as in psoriatic arthritis. -Severe pain is associated with herpes zoster (shingles), leg ulcers, and pyoderma gangrenosum. This article addresses the basics of pain classification and, in a short excerpt, pain transduction/transmission and modulation. The use of standardized diagnostic -scales is recommended for the purpose of recording and monitoring pain intensity, which allows for the optimization of therapy and consistent interdisciplinary -communication. Any dermatology residency program includes the acquisition of knowledge and skills in pain management. This review therefore aims to present fundamental therapeutic concepts based on the expanded WHO analgesic ladder, and describes a step-wise therapeutic approach and combination therapies. The article focuses on the pain management of the above-mentioned severely painful, conservatively treated dermatoses. Besides well-established therapeutic agents and current -therapeutic standards, it discusses specific options based on guidelines (where available). Current knowledge on peri- and postoperative pain management is briefly outlined. This article addresses: ▸ The fundamentals of the classification and neurophysiology of pain; ▸ Standards for pain documentation in children and adults; ▸ General standards for pharmaceutical pain management; ▸ Current specific treatment options for postherpetic neuralgia, leg ulcers, and -pyoderma gangrenosum in conjunction with the expanded WHO analgesic -ladder. © 2015 Deutsche Dermatologische Gesellschaft (DDG). Published by John Wiley & Sons Ltd.

Getting a Bigger Picture in Less Time: Viewing Curriculum Reform in a Chinese Graduate Chemistry Program through the Lens of an Organic Structure Analysis Course

ERIC Educational Resources Information Center

Ma, Jiahai

2011-01-01

As China's university enrollment has been rapidly expanding since 1999, along with a steady increase in graduate enrollment, graduate-level chemistry education is confronted with many challenges, such as how to enhance the connection between fundamental knowledge and advanced frontier knowledge, and how to encourage students to do self-directed…

Strategies for Detecting and Correcting Errors in Accounting Problems.

ERIC Educational Resources Information Center

James, Marianne L.

2003-01-01

Reviews common errors in accounting tests that students commit resulting from deficiencies in fundamental prior knowledge, ineffective test taking, and inattention to detail and provides solutions to the problems. (JOW)

Evaluation of a case-based urology learning program.

PubMed

Mishra, Kirtishri; Snow-Lisy, Devon C; Ross, Jonathan; Goldfarb, David A; Goldman, Howard; Campbell, Steven C

2013-12-01

To address the challenges that today's trainees encounter, such as information overload and reduced immersion in the field, and recognizing their preference for novel educational resources, an electronic case-based urology learning program was developed. Each case was designed to illustrate the basic principles of the disease process and the fundamentals of evaluation and management using the Socratic method, recapitulating a prototypical patient encounter. A 21-question survey was developed after review of published reports of classroom and clinical learning environment surveys. The target group was 2 pilot urology training programs (the Cleveland Clinic and University Hospitals-Case Medical Center). The responses were entirely anonymous. A total of 32 trainees participated (8 fellows and 24 residents), representing a 53% response rate. Most trainees (79%) were able to process cases within an average of ≤ 10 minutes. Of the trainees, 91% reported referring back to particular cases for patient care, to review for examinations, or for studying. Most trainees believed a case-based urology learning program would be a potentially important resource for clinical practice (69%) and for preparing for the in-service (63%) or board (69%) examinations. Most trainees believed the program met its goals of illustrating the basics principles of the disease process (88%), outlining the fundamentals of evaluation and management (94%), and improving the trainees' knowledge base (91%). An electronic case-based urology learning program is feasible and useful and stimulates learning at all trainee levels. Copyright © 2013 Elsevier Inc. All rights reserved.

Learn, see, practice, prove, do, maintain: an evidence-based pedagogical framework for procedural skill training in medicine.

PubMed

Sawyer, Taylor; White, Marjorie; Zaveri, Pavan; Chang, Todd; Ades, Anne; French, Heather; Anderson, JoDee; Auerbach, Marc; Johnston, Lindsay; Kessler, David

2015-08-01

Acquisition of competency in procedural skills is a fundamental goal of medical training. In this Perspective, the authors propose an evidence-based pedagogical framework for procedural skill training. The framework was developed based on a review of the literature using a critical synthesis approach and builds on earlier models of procedural skill training in medicine. The authors begin by describing the fundamentals of procedural skill development. Then, a six-step pedagogical framework for procedural skills training is presented: Learn, See, Practice, Prove, Do, and Maintain. In this framework, procedural skill training begins with the learner acquiring requisite cognitive knowledge through didactic education (Learn) and observation of the procedure (See). The learner then progresses to the stage of psychomotor skill acquisition and is allowed to deliberately practice the procedure on a simulator (Practice). Simulation-based mastery learning is employed to allow the trainee to prove competency prior to performing the procedure on a patient (Prove). Once competency is demonstrated on a simulator, the trainee is allowed to perform the procedure on patients with direct supervision, until he or she can be entrusted to perform the procedure independently (Do). Maintenance of the skill is ensured through continued clinical practice, supplemented by simulation-based training as needed (Maintain). Evidence in support of each component of the framework is presented. Implementation of the proposed framework presents a paradigm shift in procedural skill training. However, the authors believe that adoption of the framework will improve procedural skill training and patient safety.

A Novel BA Complex Network Model on Color Template Matching

PubMed Central

Han, Risheng; Yue, Guangxue; Ding, Hui

2014-01-01

A novel BA complex network model of color space is proposed based on two fundamental rules of BA scale-free network model: growth and preferential attachment. The scale-free characteristic of color space is discovered by analyzing evolving process of template's color distribution. And then the template's BA complex network model can be used to select important color pixels which have much larger effects than other color pixels in matching process. The proposed BA complex network model of color space can be easily integrated into many traditional template matching algorithms, such as SSD based matching and SAD based matching. Experiments show the performance of color template matching results can be improved based on the proposed algorithm. To the best of our knowledge, this is the first study about how to model the color space of images using a proper complex network model and apply the complex network model to template matching. PMID:25243235

A novel BA complex network model on color template matching.

PubMed

Han, Risheng; Shen, Shigen; Yue, Guangxue; Ding, Hui

2014-01-01

A novel BA complex network model of color space is proposed based on two fundamental rules of BA scale-free network model: growth and preferential attachment. The scale-free characteristic of color space is discovered by analyzing evolving process of template's color distribution. And then the template's BA complex network model can be used to select important color pixels which have much larger effects than other color pixels in matching process. The proposed BA complex network model of color space can be easily integrated into many traditional template matching algorithms, such as SSD based matching and SAD based matching. Experiments show the performance of color template matching results can be improved based on the proposed algorithm. To the best of our knowledge, this is the first study about how to model the color space of images using a proper complex network model and apply the complex network model to template matching.

A Community-Based Participatory Planning Process and Multilevel Intervention Design: Toward Eliminating Cardiovascular Health Inequities

PubMed Central

Schulz, Amy J.; Israel, Barbara A.; Coombe, Chris M.; Gaines, Causandra; Reyes, Angela G.; Rowe, Zachary; Sand, Sharon; Strong, Larkin L.; Weir, Sheryl

2010-01-01

The elimination of persistent health inequities requires the engagement of multiple perspectives, resources and skills. Community-based participatory research is one approach to developing action strategies that promote health equity by addressing contextual as well as individual level factors, and that can contribute to addressing more fundamental factors linked to health inequity. Yet many questions remain about how to implement participatory processes that engage local insights and expertise, are informed by the existing public health knowledge base, and build support across multiple sectors to implement solutions. We describe a CBPR approach used to conduct a community assessment and action planning process, culminating in development of a multilevel intervention to address inequalities in cardiovascular disease in Detroit, Michigan. We consider implications for future efforts to engage communities in developing strategies toward eliminating health inequities. PMID:21873580

Systems biology approach to bioremediation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chakraborty, Romy; Wu, Cindy H.; Hazen, Terry C.

2012-06-01

Bioremediation has historically been approached as a ‘black box’ in terms of our fundamental understanding. Thus it succeeds and fails, seldom without a complete understanding of why. Systems biology is an integrated research approach to study complex biological systems, by investigating interactions and networks at the molecular, cellular, community, and ecosystem level. The knowledge of these interactions within individual components is fundamental to understanding the dynamics of the ecosystem under investigation. Finally, understanding and modeling functional microbial community structure and stress responses in environments at all levels have tremendous implications for our fundamental understanding of hydrobiogeochemical processes and the potentialmore » for making bioremediation breakthroughs and illuminating the ‘black box’.« less

A bioinformatics knowledge discovery in text application for grid computing

PubMed Central

Castellano, Marcello; Mastronardi, Giuseppe; Bellotti, Roberto; Tarricone, Gianfranco

2009-01-01

Background A fundamental activity in biomedical research is Knowledge Discovery which has the ability to search through large amounts of biomedical information such as documents and data. High performance computational infrastructures, such as Grid technologies, are emerging as a possible infrastructure to tackle the intensive use of Information and Communication resources in life science. The goal of this work was to develop a software middleware solution in order to exploit the many knowledge discovery applications on scalable and distributed computing systems to achieve intensive use of ICT resources. Methods The development of a grid application for Knowledge Discovery in Text using a middleware solution based methodology is presented. The system must be able to: perform a user application model, process the jobs with the aim of creating many parallel jobs to distribute on the computational nodes. Finally, the system must be aware of the computational resources available, their status and must be able to monitor the execution of parallel jobs. These operative requirements lead to design a middleware to be specialized using user application modules. It included a graphical user interface in order to access to a node search system, a load balancing system and a transfer optimizer to reduce communication costs. Results A middleware solution prototype and the performance evaluation of it in terms of the speed-up factor is shown. It was written in JAVA on Globus Toolkit 4 to build the grid infrastructure based on GNU/Linux computer grid nodes. A test was carried out and the results are shown for the named entity recognition search of symptoms and pathologies. The search was applied to a collection of 5,000 scientific documents taken from PubMed. Conclusion In this paper we discuss the development of a grid application based on a middleware solution. It has been tested on a knowledge discovery in text process to extract new and useful information about symptoms and pathologies from a large collection of unstructured scientific documents. As an example a computation of Knowledge Discovery in Database was applied on the output produced by the KDT user module to extract new knowledge about symptom and pathology bio-entities. PMID:19534749

A bioinformatics knowledge discovery in text application for grid computing.

PubMed

Castellano, Marcello; Mastronardi, Giuseppe; Bellotti, Roberto; Tarricone, Gianfranco

2009-06-16

A fundamental activity in biomedical research is Knowledge Discovery which has the ability to search through large amounts of biomedical information such as documents and data. High performance computational infrastructures, such as Grid technologies, are emerging as a possible infrastructure to tackle the intensive use of Information and Communication resources in life science. The goal of this work was to develop a software middleware solution in order to exploit the many knowledge discovery applications on scalable and distributed computing systems to achieve intensive use of ICT resources. The development of a grid application for Knowledge Discovery in Text using a middleware solution based methodology is presented. The system must be able to: perform a user application model, process the jobs with the aim of creating many parallel jobs to distribute on the computational nodes. Finally, the system must be aware of the computational resources available, their status and must be able to monitor the execution of parallel jobs. These operative requirements lead to design a middleware to be specialized using user application modules. It included a graphical user interface in order to access to a node search system, a load balancing system and a transfer optimizer to reduce communication costs. A middleware solution prototype and the performance evaluation of it in terms of the speed-up factor is shown. It was written in JAVA on Globus Toolkit 4 to build the grid infrastructure based on GNU/Linux computer grid nodes. A test was carried out and the results are shown for the named entity recognition search of symptoms and pathologies. The search was applied to a collection of 5,000 scientific documents taken from PubMed. In this paper we discuss the development of a grid application based on a middleware solution. It has been tested on a knowledge discovery in text process to extract new and useful information about symptoms and pathologies from a large collection of unstructured scientific documents. As an example a computation of Knowledge Discovery in Database was applied on the output produced by the KDT user module to extract new knowledge about symptom and pathology bio-entities.

Using concept maps in a modified team-based learning exercise.

PubMed

Knollmann-Ritschel, Barbara E C; Durning, Steven J

2015-04-01

Medical school education has traditionally been driven by single discipline teaching and assessment. Newer medical school curricula often implement an organ-based approach that fosters integration of basic science and clinical disciplines. Concept maps are widely used in education. Through diagrammatic depiction of a variety of concepts and their specific connections with other ideas, concept maps provide a unique perspective into learning and performance that can complement other assessment methods commonly used in medical schools. In this innovation, we describe using concepts maps as a vehicle for a modified a classic Team-Based Learning (TBL) exercise. Modifications to traditional TBL in our innovation included replacing an individual assessment using multiple-choice questions with concept maps as well as combining the group assessment and application exercise whereby teams created concept maps. These modifications were made to further assess understanding of content across the Fundamentals module (the introductory module of the preclerkship curriculum). While preliminary, student performance and feedback from faculty and students support the use of concept maps in TBL. Our findings suggest concept maps can provide a unique means of determining assessment of learning and generating feedback to students. Concept maps can also demonstrate knowledge acquisition, organization of prior and new knowledge, and synthesis of that knowledge across disciplines in a unique way providing an additional means of assessment in addition to traditional multiple-choice questions. Reprint & Copyright © 2015 Association of Military Surgeons of the U.S.

Variations upon a theme: Australian lizards provide insights into the endocrine control of vertebrate reproductive cycles.

PubMed

Jones, Susan M

2017-04-01

Australian lizards exhibit a broad array of different reproductive strategies and provide an extraordinary diversity and range of models with which to address fundamental problems in reproductive biology. Studies on lizards have frequently led to new insights into hormonal regulatory pathways or mechanisms of control, but we have detailed knowledge of the reproductive cycle in only a small percentage of known species. This review provides an overview and synthesis of current knowledge of the hormonal control of reproductive cycles in Australian lizards. Agamid lizards have provided useful models with which to test hypotheses about the hormonal regulation of the expression of reproductive behaviors, while research on viviparous skinks is providing insights into the evolution of the endocrine control of gestation. However, in order to better understand the potential risks that environmental factors such as climate change and endocrine disrupting chemicals pose to our fauna, better knowledge is required of the fundamental characteristics of the reproductive cycle in a broader range of lizard species. Copyright © 2015 Elsevier Inc. All rights reserved.

Unconscious knowledge: A survey

PubMed Central

Augusto, Luís M.

2011-01-01

The concept of unconscious knowledge is fundamental for an understanding of human thought processes and mentation in general; however, the psychological community at large is not familiar with it. This paper offers a survey of the main psychological research currently being carried out into cognitive processes, and examines pathways that can be integrated into a discipline of unconscious knowledge. It shows that the field has already a defined history and discusses some of the features that all kinds of unconscious knowledge seem to share at a deeper level. With the aim of promoting further research, we discuss the main challenges which the postulation of unconscious cognition faces within the psychological community. PMID:21814538

Contemporary HIV/AIDS research: Insights from knowledge management theory.

PubMed

Callaghan, Chris William

2017-12-01

Knowledge management as a field is concerned with the management of knowledge, including the management of knowledge in research processes. Knowledge management theory has the potential to support research into problems such as HIV, antibiotic resistance and others, particularly in terms of aspects of scientific research related to the contribution of social science. To date, however, these challenges remain with us, and theoretical contributions that can complement natural science efforts to eradicate these problems are needed. This paper seeks to offer a theoretical contribution grounded in Kuhn's paradigm theory of innovation, and in the argument by Lakatos that scientific research can be fundamentally non-innovative, which suggests that social science aspects of knowledge creation may hold the key to more effective biomedical innovation. Given the consequences of ongoing and emerging global crises, and the failure of knowledge systems of scientific research to solve such problems outright, this paper provides a review of theory and literature arguing for a new paradigm in scientific research, based on the development of global systems to maximise research collaborations. A global systems approach effectively includes social science theory development as an important complement to the natural sciences research process. Arguably, information technology and social media technology have developed to the point at which solutions to knowledge aggregation challenges can enable solutions to knowledge problems on a scale hitherto unimaginable. Expert and non-expert crowdsourced inputs can enable problem-solving through exponentially increasing problem-solving inputs, using the 'crowd,' thereby increasing collaborations dramatically. It is argued that these developments herald a new era of participatory research, or a democratisation of research, which offers new hope for solving global social problems. This paper seeks to contribute to this end, and to the recognition of the important role of social theory in the scientific research process.

Manufacturing process and material selection in concurrent collaborative design of MEMS devices

NASA Astrophysics Data System (ADS)

Zha, Xuan F.; Du, H.

2003-09-01

In this paper we present knowledge of an intensive approach and system for selecting suitable manufacturing processes and materials for microelectromechanical systems (MEMS) devices in concurrent collaborative design environment. In the paper, fundamental issues on MEMS manufacturing process and material selection such as concurrent design framework, manufacturing process and material hierarchies, and selection strategy are first addressed. Then, a fuzzy decision support scheme for a multi-criteria decision-making problem is proposed for estimating, ranking and selecting possible manufacturing processes, materials and their combinations. A Web-based prototype advisory system for the MEMS manufacturing process and material selection, WebMEMS-MASS, is developed based on the client-knowledge server architecture and framework to help the designer find good processes and materials for MEMS devices. The system, as one of the important parts of an advanced simulation and modeling tool for MEMS design, is a concept level process and material selection tool, which can be used as a standalone application or a Java applet via the Web. The running sessions of the system are inter-linked with webpages of tutorials and reference pages to explain the facets, fabrication processes and material choices, and calculations and reasoning in selection are performed using process capability and material property data from a remote Web-based database and interactive knowledge base that can be maintained and updated via the Internet. The use of the developed system including operation scenario, use support, and integration with an MEMS collaborative design system is presented. Finally, an illustration example is provided.

Assessment of phase based dose modulation for improved dose efficiency in cardiac CT on an anthropomorphic motion phantom

NASA Astrophysics Data System (ADS)

Budde, Adam; Nilsen, Roy; Nett, Brian

2014-03-01

State of the art automatic exposure control modulates the tube current across view angle and Z based on patient anatomy for use in axial full scan reconstructions. Cardiac CT, however, uses a fundamentally different image reconstruction that applies a temporal weighting to reduce motion artifacts. This paper describes a phase based mA modulation that goes beyond axial and ECG modulation; it uses knowledge of the temporal view weighting applied within the reconstruction algorithm to improve dose efficiency in cardiac CT scanning. Using physical phantoms and synthetic noise emulation, we measure how knowledge of sinogram temporal weighting and the prescribed cardiac phase can be used to improve dose efficiency. First, we validated that a synthetic CT noise emulation method produced realistic image noise. Next, we used the CT noise emulation method to simulate mA modulation on scans of a physical anthropomorphic phantom where a motion profile corresponding to a heart rate of 60 beats per minute was used. The CT noise emulation method matched noise to lower dose scans across the image within 1.5% relative error. Using this noise emulation method to simulate modulating the mA while keeping the total dose constant, the image variance was reduced by an average of 11.9% on a scan with 50 msec padding, demonstrating improved dose efficiency. Radiation dose reduction in cardiac CT can be achieved while maintaining the same level of image noise through phase based dose modulation that incorporates knowledge of the cardiac reconstruction algorithm.

Planets and satellites: A survey of fundamental facts

NASA Technical Reports Server (NTRS)

Kopal, Z.

1972-01-01

An account of the fundamental properties of the planets of the solar system and of their satellites including their masses, dimensions and distances is presented. The observational uncertainty in present knowledge of planetary masses and dimensions (or mean densities) is discussed critically. The fact is pointed out that the initial scale of the solar system may have differed appreciably from the present one. Observed phenomena which can furnish empirical information on the internal structure of the planetary globes will also be reviewed.

Reading is fundamentally similar across disparate writing systems: A systematic characterization of how words and characters influence eye movements in Chinese reading

PubMed Central

Li, Xingshan; Bicknell, Klinton; Liu, Pingping; Wei, Wei; Rayner, Keith

2013-01-01

While much previous work on reading in languages with alphabetic scripts has suggested that reading is word-based, reading in Chinese has been argued to be less reliant on words. This is primarily because in the Chinese writing system words are not spatially segmented, and characters are themselves complex visual objects. Here, we present a systematic characterization of the effects of a wide range of word and character properties on eye movements in Chinese reading, using a set of mixed-effects regression models. The results reveal a rich pattern of effects of the properties of the current, previous, and next words on a range of reading measures, which is strikingly similar to the pattern of effects of word properties reported in spaced alphabetic languages. This finding provides evidence that reading shares a word-based core and may be fundamentally similar across languages with highly dissimilar scripts. We show that these findings are robust to the inclusion of character properties in the regression models, and are equally reliable when dependent measures are defined in terms of characters rather than words, providing strong evidence that word properties have effects in Chinese reading above and beyond characters. This systematic characterization of the effects of word and character properties in Chinese advances our knowledge of the processes underlying reading and informs the future development of models of reading. More generally, however, this work suggests that differences in script may not alter the fundamental nature of reading. PMID:23834023

Permeability barrier of Gram-negative cell envelopes and approaches to bypass it

DOE PAGES

Zgurskaya, Helen I.; López, Cesar A.; Gnanakaran, Sandrasegaram

2015-09-18

Gram-negative bacteria are intrinsically resistant to many antibiotics. Species that have acquired multidrug resistance and cause infections that are effectively untreatable present a serious threat to public health. The problem is broadly recognized and tackled at both the fundamental and applied levels. This article summarizes current advances in understanding the molecular bases of the low permeability barrier of Gram-negative pathogens, which is the major obstacle in discovery and development of antibiotics effective against such pathogens. Gaps in knowledge and specific strategies to break this barrier and to achieve potent activities against difficult Gram-negative bacteria are also discussed.

Analysis of the velocity distribution in different types of ventilation system ducts

NASA Astrophysics Data System (ADS)

Peszyński, Kazimierz; Olszewski, Lukasz; Smyk, Emil; Perczyński, Daniel

2018-06-01

The paper presents the results obtained during the preliminary studies of circular and rectangular ducts before testing the properties elements (elbows, tees, etc.)of rectangular with rounded corners ducts. The fundamental problem of the studies was to determine the flow rate in the ventilation duct. Due to the size of the channel it was decided to determine the flow rate based on the integration of flow velocity over the considered cross-section. This method requires knowledge of the velocity distribution in the cross section. Approximation of the measured actual profile by the classic and modified Prandtl power-law velocity profile was analysed.

[A role of Russian psychiatrists in the formation of forensic psychiatry in Russia in the beginning of XIX century].

PubMed

Bezchasniy, K V

2016-01-01

The formation of forensic psychiatry knowledge as a special area of concern was due to fundamental changes in the social, economic and political life of Russia society. It reflected public awareness of the urgent need in solving the problem of support, preserve and maintain the mental health of the people. Forensic psychiatry was based on the development of psychiatry, public health and community medicine. Author describes of the role of Russian psychiatrists in the formation of forensic psychiatry, their active particitpation in internation professional meetings and in the development of the problem of responsibility.

Permeability barrier of Gram-negative cell envelopes and approaches to bypass it

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zgurskaya, Helen I.; López, Cesar A.; Gnanakaran, Sandrasegaram

Gram-negative bacteria are intrinsically resistant to many antibiotics. Species that have acquired multidrug resistance and cause infections that are effectively untreatable present a serious threat to public health. The problem is broadly recognized and tackled at both the fundamental and applied levels. This article summarizes current advances in understanding the molecular bases of the low permeability barrier of Gram-negative pathogens, which is the major obstacle in discovery and development of antibiotics effective against such pathogens. Gaps in knowledge and specific strategies to break this barrier and to achieve potent activities against difficult Gram-negative bacteria are also discussed.

Patient-centered applications: use of information technology to promote disease management and wellness. A white paper by the AMIA knowledge in motion working group.

PubMed

Demiris, George; Afrin, Lawrence B; Speedie, Stuart; Courtney, Karen L; Sondhi, Manu; Vimarlund, Vivian; Lovis, Christian; Goossen, William; Lynch, Cecil

2008-01-01

Advances in information technology (IT) enable a fundamental redesign of health care processes based on the use and integration of electronic communication at all levels. New communication technologies can support a transition from institution centric to patient-centric applications. This white paper defines key principles and challenges for designers, policy makers, and evaluators of patient-centered technologies for disease management and prevention. It reviews current and emerging trends; highlights challenges related to design, evaluation, reimbursement and usability; and reaches conclusions for next steps that will advance the domain.

Contributions of the Clementine mission to our understanding of the processes and history of the Moon

NASA Technical Reports Server (NTRS)

Spudis, Paul D.; Lucey, Paul G.

1993-01-01

The Clementine mission will provide us with an abundance of information about lunar surface morphology, topography, and composition, and it will permit us to infer the history of the Moon and the processes that have shaped that history. This information can be used to address fundamental questions in lunar science and allow us to make significant advances towards deciphering the complex story of the Moon. The Clementine mission will also permit a first-order global assessment of the resources of the Moon and provide a strategic base of knowledge upon which future robotic and human missions to the Moon can build.

Toward a patient-centric medical information model: issues and challenges for US adoption.

PubMed

Lorence, Daniel; Monatesti, Sabatini; Margenthaler, Robert; Hoadley, Ellen

2005-01-01

As the USA moves, incrementally, toward evidence-based medicine, there is growing awareness of the importance of innovation in information management. Mandates for change include improved use of resources, accelerated diffusion of knowledge and an advanced consumer role. Key among these requirements is the need for a fundamentally different patient information recording system. Within the challenges identified in the most recent national health information technology initiative, we propose a model for an electronic, patient-centric medical information infrastructure, highlighting a transportable, scalable and integrated resource. We identify resources available for technology transfer, promoting consumers as integral parts of the collaborative medical decision-making process.

Patient-centered Applications: Use of Information Technology to Promote Disease Management and Wellness. A White Paper by the AMIA Knowledge in Motion Working Group

PubMed Central

Demiris, George; Afrin, Lawrence B.; Speedie, Stuart; Courtney, Karen L.; Sondhi, Manu; Vimarlund, Vivian; Lovis, Christian; Goossen, William; Lynch, Cecil

2008-01-01

Advances in information technology (IT) enable a fundamental redesign of health care processes based on the use and integration of electronic communication at all levels. New communication technologies can support a transition from institution centric to patient-centric applications. This white paper defines key principles and challenges for designers, policy makers, and evaluators of patient-centered technologies for disease management and prevention. It reviews current and emerging trends; highlights challenges related to design, evaluation, reimbursement and usability; and reaches conclusions for next steps that will advance the domain. PMID:17947617

The principles of teratology: are they still true?

PubMed

Friedman, Jan M

2010-10-01

James Wilson originally proposed a set of "Principles of Teratology" in 1959, the year before he helped to found the Teratology Society. By 1977, when these Principles were presented in a more definitive form in Wilson and Fraser's Handbook of Teratology, they had become a standard formulation of the basic tenets of the field. Wilson's Principles have continued to guide scientific research in teratology, and they are widely used in teaching. Recent advances in our knowledge of the molecular and cellular bases of embryogenesis serve only to provide a deeper understanding of the fundamental developmental mechanisms that underlie Wilson's Principles of Teratology. © 2010 Wiley-Liss, Inc.

Cyberspace, Distance Learning, and Higher Education in Developing Countries: Old and Emergent Issues of Access, Pedagogy, and Knowledge Production. International Studies in Sociology and Social Anthropology, 94

ERIC Educational Resources Information Center

Assie-Lumumba, N'Dri T., Ed.

2004-01-01

Amidst the euphoria about the new frontiers of technology sometimes perceived as a panacea for expansion of higher education in developing countries, there is a need to analyze persistent and new grounds of unequal opportunity for access, learning, and the production of knowledge. This volume addresses fundamental questions about the educational…

Knowledge Requirements and Management in Expert Decision Support Systems for (Military) Situation Assessment

DTIC Science & Technology

1983-08-01

constitutes a fundamental problem in many decision making processes. In business management we face this problem when determining the status of an...Tehiical Report 576 ( 1 ) 4 KNOWLEDGE REQUIREMENTS AND MANAGEMENT IN EXPERT DECISION SUPPORT SYSTEMS FOR (MILITARY) SITUATION ASSESSMENT MOOM sen...accomplished under contract for the Department of the Army The Israel Institute of Business Research Technical review by Robert H. Sasmor Joseph M

Global knowledge, local implications: a community college's response

NASA Astrophysics Data System (ADS)

Valentin, Marjorie R.; Stroup, Margaret H.; Donnelly, Judith F.

2005-10-01

Three Rivers Community College (TRCC), with federal funding, provided a customized laser program for Joining Technologies in Connecticut, which offers world-class resources for welding and joining applications. This program addresses the shortage of skilled labor in the laser arena, lack of knowledge of fundamental science of applied light, and an increase in nonperforming product. Hiring and retraining a skilled workforce are important and costly issues facing today's small manufacturing companies.

Integrating developed and developing world knowledge into global discussions and strategies for sustainability. 1. Science and technology.

PubMed

Mihelcic, James R; Zimmerman, Julie B; Ramaswami, Anu

2007-05-15

Sustainable development in both the developed and developing world has the common fundamental themes of advancing economic and social prosperity while protecting and restoring natural systems. While many recent efforts have been undertaken to transfer knowledge from the developed to the developing world to achieve a more sustainable future, indigenous knowledge that often originates in developing nations also can contribute significantly to this global dialogue. Selected case studies are presented to describe important knowledge, methodologies, techniques, principles, and practices for sustainable development emerging from developing countries in two critical challenge areas to sustainability: water and energy. These, with additional analysis and quantification, can be adapted and expanded for transfer throughout the developed and developing world in advancing sustainability. A common theme in all of the case studies presented is the integration of natural processes and material flows into the anthropogenic system. Some of these techniques, originating in rural settings, have recently been adapted for use in cities, which is especially important as the global trend of urban population growth accelerates. Innovations in science and technology, specifically applied to two critical issues of today, water and energy, are expected to fundamentally shift the type and efficiency of energy and materials utilized to advance prosperity while protecting and restoring natural systems.

Using program evaluation to support knowledge translation in an interprofessional primary care team: a case study.

PubMed

Donnelly, Catherine; Shulha, Lyn; Klinger, Don; Letts, Lori

2016-10-06

Evaluation is a fundamental component in building quality primary care and is ideally situated to support individual, team and organizational learning by offering an accessible form of participatory inquiry. The evaluation literature has begun to recognize the unique features of KT evaluations and has described attributes to consider when evaluating KT activities. While both disciplines have focused on the evaluation of KT activities neither has explored the role of evaluation in KT. The purpose of the paper is to examine how participation in program evaluation can support KT in a primary care setting. A mixed methods case study design was used, where evaluation was conceptualized as a change process and intervention. A Memory Clinic at an interprofessional primary care clinic was the setting in which the study was conducted. An evaluation framework, Pathways of Influence provided the theoretical foundation to understand how program evaluation can facilitate the translation of knowledge at the level of the individual, inter-personal (Memory Clinic team) and the organization. Data collection included questionnaires, interviews, evaluation log and document analysis. Questionnaires and interviews were administered both before and after the evaluation: Pattern matching was used to analyze the data based on predetermined propositions. Individuals gained program knowledge that resulted in changes to both individual and program practices. One of the key themes was the importance clinicians placed on local, program based knowledge. The evaluation had less influence on the broader health organization. Program evaluation facilitated individual, team and organizational learning. The use of evaluation to support KT is ideally suited to a primary care setting by offering relevant and applicable knowledge to primary care team members while being sensitive to local context.

Reproduction, physiology and biochemistry

USDA-ARS?s Scientific Manuscript database

This chapter summarizes fundamental knowledge and recent discoveries about the reproduction, physiology and biochemistry of plant-parasitic nematodes. Various types of reproduction are reviewed, including sexual reproduction and mitotic and meiotic parthenogenesis. Although much is known about the p...

Biochemistry

USDA-ARS?s Scientific Manuscript database

Part of the framework for effective control or management of cyst nematodes depends upon the detailed understanding of their biology. This chapter summarizes fundamental knowledge and recent discoveries about the biochemistry of cyst nematodes, particularly areas related to lipids, carbohydrates and...

75 FR 71317 - Fundamental Principles and Policymaking Criteria for Partnerships With Faith-Based and Other...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-22

... Part IV The President Executive Order 13559--Fundamental Principles and Policymaking Criteria for... Fundamental Principles and Policymaking Criteria for Partnerships With Faith-Based and Other Neighborhood... the following: ``Sec. 2. Fundamental Principles. In formulating and implementing policies that have...

Comparison of technology-based cooperative learning with technology-based individual learning in enhancing fundamental nursing proficiency.

PubMed

Lin, Zu-Chun

2013-05-01

The aim of nursing education is to prepare students with critical thinking, high interests in profession and high proficiency in patient care. Cooperative learning promotes team work and encourages knowledge building upon discussion. It has been viewed as one of the most powerful learning methods. Technology has been considered an influential tool in teaching and learning. It assists students in gathering more information to solve the problems and master skills better. The purpose of this study was to compare the effect of technology-based cooperative learning with technology-based individual learning in nursing students' critical thinking in catheterization knowledge gaining, error discovering, skill acquisitions, and overall scores. This study used a pretest-posttest experimental design. Ninety-eight students were assigned randomly to one of two groups. Questionnaires and tests were collected at baseline and after completion of intervention. The results of this study showed that there was no significant difference in related catheterization skill performance. However, the remaining variables differed greatly between the two groups. CONCLUSIONS AND APPLICATIONS: This study's findings guide the researchers and instructors to use technology-based cooperative learning more appropriately. Future research should address the design of the course module and the availability of mobile devices to reach student-centered and learn on the move goals. Copyright © 2011 Elsevier Ltd. All rights reserved.

Nitrosamines and Nitramines in Amine-Based Carbon Dioxide Capture Systems: Fundamentals, Engineering Implications, and Knowledge Gaps.

PubMed

Yu, Kun; Mitch, William A; Dai, Ning

2017-10-17

Amine-based absorption is the primary contender for postcombustion CO 2 capture from fossil fuel-fired power plants. However, significant concerns have arisen regarding the formation and emission of toxic nitrosamine and nitramine byproducts from amine-based systems. This paper reviews the current knowledge regarding these byproducts in CO 2 capture systems. In the absorber, flue gas NO x drives nitrosamine and nitramine formation after its dissolution into the amine solvent. The reaction mechanisms are reviewed based on CO 2 capture literature as well as biological and atmospheric chemistry studies. In the desorber, nitrosamines are formed under high temperatures by amines reacting with nitrite (a hydrolysis product of NO x ), but they can also thermally decompose following pseudo-first order kinetics. The effects of amine structure, primarily amine order, on nitrosamine formation and the corresponding mechanisms are discussed. Washwater units, although intended to control emissions from the absorber, can contribute to additional nitrosamine formation when accumulated amines react with residual NO x . Nitramines are much less studied than nitrosamines in CO 2 capture systems. Mitigation strategies based on the reaction mechanisms in each unit of the CO 2 capture systems are reviewed. Lastly, we highlight research needs in clarifying reaction mechanisms, developing analytical methods for both liquid and gas phases, and integrating different units to quantitatively predict the accumulation and emission of nitrosamines and nitramines.

Polarization-sensitive optical coherence tomography using continuous polarization modulation with arbitrary phase modulation amplitude

NASA Astrophysics Data System (ADS)

Lu, Zenghai; Kasaragod, Deepa K.; Matcher, Stephen J.

2012-03-01

We demonstrate theoretically and experimentally that the phase retardance and relative optic-axis orientation of a sample can be calculated without prior knowledge of the actual value of the phase modulation amplitude when using a polarization-sensitive optical coherence tomography system based on continuous polarization modulation (CPM-PS-OCT). We also demonstrate that the sample Jones matrix can be calculated at any values of the phase modulation amplitude in a reasonable range depending on the system effective signal-to-noise ratio. This has fundamental importance for the development of clinical systems by simplifying the polarization modulator drive instrumentation and eliminating its calibration procedure. This was validated on measurements of a three-quarter waveplate and an equine tendon sample by a fiber-based swept-source CPM-PS-OCT system.

Constructing Model of Relationship among Behaviors and Injuries to Products Based on Large Scale Text Data on Injuries

NASA Astrophysics Data System (ADS)

Nomori, Koji; Kitamura, Koji; Motomura, Yoichi; Nishida, Yoshifumi; Yamanaka, Tatsuhiro; Komatsubara, Akinori

In Japan, childhood injury prevention is urgent issue. Safety measures through creating knowledge of injury data are essential for preventing childhood injuries. Especially the injury prevention approach by product modification is very important. The risk assessment is one of the most fundamental methods to design safety products. The conventional risk assessment has been carried out subjectively because product makers have poor data on injuries. This paper deals with evidence-based risk assessment, in which artificial intelligence technologies are strongly needed. This paper describes a new method of foreseeing usage of products, which is the first step of the evidence-based risk assessment, and presents a retrieval system of injury data. The system enables a product designer to foresee how children use a product and which types of injuries occur due to the product in daily environment. The developed system consists of large scale injury data, text mining technology and probabilistic modeling technology. Large scale text data on childhood injuries was collected from medical institutions by an injury surveillance system. Types of behaviors to a product were derived from the injury text data using text mining technology. The relationship among products, types of behaviors, types of injuries and characteristics of children was modeled by Bayesian Network. The fundamental functions of the developed system and examples of new findings obtained by the system are reported in this paper.

Automatic two- and three-dimensional mesh generation based on fuzzy knowledge processing

NASA Astrophysics Data System (ADS)

Yagawa, G.; Yoshimura, S.; Soneda, N.; Nakao, K.

1992-09-01

This paper describes the development of a novel automatic FEM mesh generation algorithm based on the fuzzy knowledge processing technique. A number of local nodal patterns are stored in a nodal pattern database of the mesh generation system. These nodal patterns are determined a priori based on certain theories or past experience of experts of FEM analyses. For example, such human experts can determine certain nodal patterns suitable for stress concentration analyses of cracks, corners, holes and so on. Each nodal pattern possesses a membership function and a procedure of node placement according to this function. In the cases of the nodal patterns for stress concentration regions, the membership function which is utilized in the fuzzy knowledge processing has two meanings, i.e. the “closeness” of nodal location to each stress concentration field as well as “nodal density”. This is attributed to the fact that a denser nodal pattern is required near a stress concentration field. What a user has to do in a practical mesh generation process are to choose several local nodal patterns properly and to designate the maximum nodal density of each pattern. After those simple operations by the user, the system places the chosen nodal patterns automatically in an analysis domain and on its boundary, and connects them smoothly by the fuzzy knowledge processing technique. Then triangular or tetrahedral elements are generated by means of the advancing front method. The key issue of the present algorithm is an easy control of complex two- or three-dimensional nodal density distribution by means of the fuzzy knowledge processing technique. To demonstrate fundamental performances of the present algorithm, a prototype system was constructed with one of object-oriented languages, Smalltalk-80 on a 32-bit microcomputer, Macintosh II. The mesh generation of several two- and three-dimensional domains with cracks, holes and junctions was presented as examples.

Development and preliminary evaluation of a practice-based learning and improvement tool for assessing resident competence and guiding curriculum development.

PubMed

Lawrence, Renée H; Tomolo, Anne M

2011-03-01

Although practice-based learning and improvement (PBLI) is now recognized as a fundamental and necessary skill set, we are still in need of tools that yield specific information about gaps in knowledge and application to help nurture the development of quality improvement (QI) skills in physicians in a proficient and proactive manner. We developed a questionnaire and coding system as an assessment tool to evaluate and provide feedback regarding PBLI self-efficacy, knowledge, and application skills for residency programs and related professional requirements. Five nationally recognized QI experts/leaders reviewed and completed our questionnaire. Through an iterative process, a coding system based on identifying key variables needed for ideal responses was developed to score project proposals. The coding system comprised 14 variables related to the QI projects, and an additional 30 variables related to the core knowledge concepts related to PBLI. A total of 86 residents completed the questionnaire, and 2 raters coded their open-ended responses. Interrater reliability was assessed by percentage agreement and Cohen κ for individual variables and Lin concordance correlation for total scores for knowledge and application. Discriminative validity (t test to compare known groups) and coefficient of reproducibility as an indicator of construct validity (item difficulty hierarchy) were also assessed. Interrater reliability estimates were good (percentage of agreements, above 90%; κ, above 0.4 for most variables; concordances for total scores were R  =  .88 for knowledge and R  =  .98 for application). Despite the residents' limited range of experiences in the group with prior PBLI exposure, our tool met our goal of differentiating between the 2 groups in our preliminary analyses. Correcting for chance agreement identified some variables that are potentially problematic. Although additional evaluation is needed, our tool may prove helpful and provide detailed information about trainees' progress and the curriculum.

Development and Preliminary Evaluation of a Practice-Based Learning and Improvement Tool for Assessing Resident Competence and Guiding Curriculum Development

PubMed Central

Lawrence, Renée H; Tomolo, Anne M

2011-01-01

Background Although practice-based learning and improvement (PBLI) is now recognized as a fundamental and necessary skill set, we are still in need of tools that yield specific information about gaps in knowledge and application to help nurture the development of quality improvement (QI) skills in physicians in a proficient and proactive manner. We developed a questionnaire and coding system as an assessment tool to evaluate and provide feedback regarding PBLI self-efficacy, knowledge, and application skills for residency programs and related professional requirements. Methods Five nationally recognized QI experts/leaders reviewed and completed our questionnaire. Through an iterative process, a coding system based on identifying key variables needed for ideal responses was developed to score project proposals. The coding system comprised 14 variables related to the QI projects, and an additional 30 variables related to the core knowledge concepts related to PBLI. A total of 86 residents completed the questionnaire, and 2 raters coded their open-ended responses. Interrater reliability was assessed by percentage agreement and Cohen κ for individual variables and Lin concordance correlation for total scores for knowledge and application. Discriminative validity (t test to compare known groups) and coefficient of reproducibility as an indicator of construct validity (item difficulty hierarchy) were also assessed. Results Interrater reliability estimates were good (percentage of agreements, above 90%; κ, above 0.4 for most variables; concordances for total scores were R  =  .88 for knowledge and R  =  .98 for application). Conclusion Despite the residents' limited range of experiences in the group with prior PBLI exposure, our tool met our goal of differentiating between the 2 groups in our preliminary analyses. Correcting for chance agreement identified some variables that are potentially problematic. Although additional evaluation is needed, our tool may prove helpful and provide detailed information about trainees' progress and the curriculum. PMID:22379522

The role of hardware in learning engineering fundamentals: An empirical study of engineering design and product analysis activity

NASA Astrophysics Data System (ADS)

Brereton, Margot Felicity

A series of short engineering exercises and design projects was created to help students learn to apply abstract knowledge to physical experiences with hardware. The exercises involved designing machines from kits of materials and dissecting and analyzing familiar household products. Students worked in teams. During the activities students brought their knowledge of engineering fundamentals to bear. Videotape analysis was used to identify and characterize the ways in which hardware contributed to learning fundamental concepts. Structural and qualitative analyses of videotaped activities were undertaken. Structural analysis involved counting the references to theory and hardware and the extent of interleaving of references in activity. The analysis found that there was much more discussion linking fundamental concepts to hardware in some activities than in others. The analysis showed that the interleaving of references to theory and hardware in activity is observable and quantifiable. Qualitative analysis was used to investigate the dialog linking concepts and hardware. Students were found to advance their designs and their understanding of engineering fundamentals through a negotiation process in which they pitted abstract concepts against hardware behavior. Through this process students sorted out theoretical assumptions and causal relations. In addition they discovered design assumptions, functional connections and physical embodiments of abstract concepts in hardware, developing a repertoire of familiar hardware components and machines. Hardware was found to be integral to learning, affecting the course of inquiry and the dynamics of group interaction. Several case studies are presented to illustrate the processes at work. The research illustrates the importance of working across the boundary between abstractions and experiences with hardware in order to learn engineering and physical sciences. The research findings are: (a) the negotiation process by which students discover fundamental concepts in hardware (and three central causes of negotiation breakdown); (b) a characterization of the ways that material systems contribute to learning activities, (the seven roles of hardware in learning); (c) the characteristics of activities that support discovering fundamental concepts in hardware (plus several engineering exercises); (d) a research methodology to examine how students learn in practice.

Mind the gap! Lay and medical perceptions of risks associated with the use of alternative treatment and conventional medicine.

PubMed

Salamonsen, Anita

2015-01-01

Studies on the widespread use of complementary and alternative medicine (CAM) demonstrate that CAM users base their treatment decisions on both subjective, experience-based knowledge and medical knowledge. The aim of this study was to explore lay and medical risk perceptions associated with CAM and conventional medicine. In this explorative qualitative study, we conducted in-depth interviews with 25 Norwegian CAM users with cancer or multiple sclerosis and 12 doctors. The interviews revealed fundamental differences in risk perceptions influencing treatment decisions and risk communication in a clinical setting. While CAM users considered conventional medicine as potentially risky and related this to experiences of severe adverse effects, CAM was perceived as natural and safe. Doctors' risk perceptions were quite the contrary, mainly because of lack of scientific evidence for CAM as a safe and beneficial treatment option. For the safety of CAM users, such divergent risk perceptions may have far-reaching consequences. CAM users should be taken seriously with their self-perception as decision-makers considering their approaches to experiences, knowledge, and science. An awareness of differing lay and medical risk perceptions associated with CAM and conventional medicine in research, doctor-patient communication, and education of patients and doctors is thus important to optimize patient safety in complex health care systems. © 2015 S. Karger GmbH, Freiburg.

Geosynthetic Reinforced Soil Integrated Bridge System, Synthesis Report

DOT National Transportation Integrated Search

2011-01-01

This report is the second in a two-part series to provide engineers with the necessary background knowledge of Geosynthetic Reinforced Soil (GRS) technology and its fundamental characteristics as an alternative to other construction methods. It suppl...

Knowledge brokerage - potential for increased capacities and shared power in impact assessment

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rosario Partidario, Maria, E-mail: mrp@civil.ist.utl.pt; Sheate, William R., E-mail: w.sheate@imperial.ac.uk; Collingwood Environmental Planning Ltd, London, 1E, The Chandlery, 50 Westminster Bridge Road, London SE1 7QY

2013-02-15

Constructive and collaborative planning theory has exposed the perceived limitations of public participation in impact assessment. At strategic levels of assessment the established norm can be misleading and practice is illusive. For example, debates on SEA effectiveness recognize insufficiencies, but are often based on questionable premises. The authors of this paper argue that public participation in strategic assessment requires new forms of information and engagement, consistent with the complexity of the issues at these levels and that strategic assessments can act as knowledge brokerage instruments with the potential to generate more participative environments and attitudes. The paper explores barriers andmore » limitations, as well as the role of knowledge brokerage in stimulating the engagement of the public, through learning-oriented processes and responsibility sharing in more participative models of governance. The paper concludes with a discussion on building and inter-change of knowledge, towards creative solutions to identified problems, stimulating learning processes, largely beyond simple information transfer mechanisms through consultative processes. The paper argues fundamentally for the need to conceive strategic assessments as learning platforms and design knowledge brokerage opportunities explicitly as a means to enhance learning processes and power sharing in IA. - Highlights: Black-Right-Pointing-Pointer Debates on SEA recognize insufficiencies on public participation Black-Right-Pointing-Pointer We propose new forms of engagement consistent with complex situations at strategic levels of decision-making Black-Right-Pointing-Pointer Constructive and collaborative planning theories help explain how different actors acquire knowledge and the value of knowledge exchange Black-Right-Pointing-Pointer Strategic assessments can act as knowledge brokerage instruments Black-Right-Pointing-Pointer The paper argues for strategic assessments as learning platforms as a means to enhance learning processes and power sharing in IA.« less

In search of the origin of mass.

PubMed

Shears, T G; Heinemann, B; Waters, D

2006-12-15

Particle physics explores the structure of matter by studying the behaviour of its most fundamental constituents. Despite the remarkable success of our theories, there remains much that is fundamental but unexplained. One of our most pressing questions concerns the origin of mass. Our favoured theoretical explanation for the existence of mass also predicts the existence of a particle that has never been seen-the Higgs boson. In this review, we survey our knowledge of the Higgs boson and explain why, if the theory is correct, we should expect to make our first observation of the elusive Higgs in the next few years, when a major new particle physics facility starts operating. This will be the most powerful particle accelerator in the world. Although searching for the Higgs boson will be challenging in this environment, we hope that our experimental results will allow us to finally understand the origin of mass and extend our knowledge of the Universe yet further.

Intelligence: is it the epidemiologists' elusive "fundamental cause" of social class inequalities in health?

PubMed

Gottfredson, Linda S

2004-01-01

Virtually all indicators of physical health and mental competence favor persons of higher socioeconomic status (SES). Conventional theories in the social sciences assume that the material disadvantages of lower SES are primarily responsible for these inequalities, either directly or by inducing psychosocial harm. These theories cannot explain, however, why the relation between SES and health outcomes (knowledge, behavior, morbidity, and mortality) is not only remarkably general across time, place, disease, and kind of health system but also so finely graded up the entire SES continuum. Epidemiologists have therefore posited, but not yet identified, a more general "fundamental cause" of health inequalities. This article concatenates various bodies of evidence to demonstrate that differences in general intelligence (g) may be that fundamental cause.

Linking the subcultures of physics: virtual empiricism and the bonding role of trust.

PubMed

Reyes-Galindo, Luis

2014-10-01

This article draws on empirical material concerning the communication and use of knowledge in experimental physics and its relations to the culture of theoretical physics. The role that trust plays in these interactions is used to create a model of social distance between interacting theoretical and experimental cultures. This article thus seeks to reintroduce trust as a fundamental element in answering the problem of disunity in the sociology of knowledge.

[The cancer registry is fundamental for the treatment, prevention and control of childhood cancer].

PubMed

González-Miranda, Guadalupe; Fajardo-Gutiérrez, Arturo

2011-01-01

During the last 10 years cancer in the Mexican pediatric population is growing. It is the second leading cause of death (children 1 to 14 years of age). The first step in controlling these diseases by registering the cases. Cancer Registry (CR) is fundamental for gaining knowledge that can be used for planning medical treatment and future research into causal factors and for the prevention. A CR is an information system designed to collect and encode data concerning individuals with cancer, and then to disseminate the compiled epidemiological results to various groups of stakeholders. Data are obtained from a hospital or group of hospitals, with special emphasis being placed on the quality of the data (completeness, validity and timeliness data). It is necessary a group of highly trained individuals called registrars, who are experts in the collection, encoding, and dissemination of internal reports to researchers and medical personnel. There are two main types of registries: those that are hospital based and those that are population based. The categories of data that should be collected are demographic data of the patient; descriptors of the cancer; details of the treatment administered; and details of the outcome of the treatment. It must be emphasized that all data conceming patients with cancer should be held in the strictest confidence.

Deriving high-resolution protein backbone structure propensities from all crystal data using the information maximization device.

PubMed

Solis, Armando D

2014-01-01

The most informative probability distribution functions (PDFs) describing the Ramachandran phi-psi dihedral angle pair, a fundamental descriptor of backbone conformation of protein molecules, are derived from high-resolution X-ray crystal structures using an information-theoretic approach. The Information Maximization Device (IMD) is established, based on fundamental information-theoretic concepts, and then applied specifically to derive highly resolved phi-psi maps for all 20 single amino acid and all 8000 triplet sequences at an optimal resolution determined by the volume of current data. The paper shows that utilizing the latent information contained in all viable high-resolution crystal structures found in the Protein Data Bank (PDB), totaling more than 77,000 chains, permits the derivation of a large number of optimized sequence-dependent PDFs. This work demonstrates the effectiveness of the IMD and the superiority of the resulting PDFs by extensive fold recognition experiments and rigorous comparisons with previously published triplet PDFs. Because it automatically optimizes PDFs, IMD results in improved performance of knowledge-based potentials, which rely on such PDFs. Furthermore, it provides an easy computational recipe for empirically deriving other kinds of sequence-dependent structural PDFs with greater detail and precision. The high-resolution phi-psi maps derived in this work are available for download.

Toward a microgravity research strategy

NASA Technical Reports Server (NTRS)

1992-01-01

Recommendations of the Committee on Microgravity Research (CMGR) of the Space Studies Board of the National Research Council are found in the Summary and Recommendations in the front of the report. The CMGR recommends a long-range research strategy. The main rationale for the microgravity research program should be to improve our fundamental scientific and technical knowledge base, particularly in the areas that are likely to lead to improvements in processing and manufacturing on earth. The CMGR recommends research be categorized as Biological science and technology, Combustion, Fluid science, Fundamental phenomena, Materials, and Processing science and technology. The committee also recommends that NASA apply a set of value criteria and measurement indicators to define the research and analysis program more clearly. The CMGR recommends that the funding level for research and analysis in microgravity science be established as a fixed percentage of the total program of NASA's Microgravity Science and Applications Division in order to build a strong scientific base for future experiments. The committee also recommends a cost-effective approach to experiments. Finally the CMGR recommends that a thorough technical review of the centers for commercial development of space be conducted to determine the quality of their activities and to ascertain to what degree their original mission has been accomplished.

Conceptual knowledge representation: A cross-section of current research.

PubMed

Rogers, Timothy T; Wolmetz, Michael

2016-01-01

How is conceptual knowledge encoded in the brain? This special issue of Cognitive Neuropsychology takes stock of current efforts to answer this question through a variety of methods and perspectives. Across this work, three questions recur, each fundamental to knowledge representation in the mind and brain. First, what are the elements of conceptual representation? Second, to what extent are conceptual representations embodied in sensory and motor systems? Third, how are conceptual representations shaped by context, especially linguistic context? In this introductory article we provide relevant background on these themes and introduce how they are addressed by our contributing authors.

Crossing boundaries in interprofessional education: A call for instructional integration of two script concepts.

PubMed

Kiesewetter, Jan; Kollar, Ingo; Fernandez, Nicolas; Lubarsky, Stuart; Kiessling, Claudia; Fischer, Martin R; Charlin, Bernard

2016-09-01

Clinical work occurs in a context which is heavily influenced by social interactions. The absence of theoretical frameworks underpinning the design of collaborative learning has become a roadblock for interprofessional education (IPE). This article proposes a script-based framework for the design of IPE. This framework provides suggestions for designing learning environments intended to foster competences we feel are fundamental to successful interprofessional care. The current literature describes two script concepts: "illness scripts" and "internal/external collaboration scripts". Illness scripts are specific knowledge structures that link general disease categories and specific examples of diseases. "Internal collaboration scripts" refer to an individual's knowledge about how to interact with others in a social situation. "External collaboration scripts" are instructional scaffolds designed to help groups collaborate. Instructional research relating to illness scripts and internal collaboration scripts supports (a) putting learners in authentic situations in which they need to engage in clinical reasoning, and (b) scaffolding their interaction with others with "external collaboration scripts". Thus, well-established experiential instructional approaches should be combined with more fine-grained script-based scaffolding approaches. The resulting script-based framework offers instructional designers insights into how students can be supported to develop the necessary skills to master complex interprofessional clinical situations.

Synthesizing Quantitative Evidence for Evidence-based Nursing: Systematic Review.

PubMed

Oh, Eui Geum

2016-06-01

As evidence-based practice has become an important issue in healthcare settings, the educational needs for knowledge and skills for the generation and utilization of healthcare evidence are increasing. Systematic review (SR), a way of evidence generation, is a synthesis of primary scientific evidence, which summarizes the best evidence on a specific clinical question using a transparent, a priori protocol driven approach. SR methodology requires a critical appraisal of primary studies, data extraction in a reliable and repeatable way, and examination for validity of the results. SRs are considered hierarchically as the highest form of evidence as they are a systematic search, identification, and summarization of the available evidence to answer a focused clinical question with particular attention to the methodological quality of studies or the credibility of opinion and text. The purpose of this paper is to introduce an overview of the fundamental knowledge, principals and processes in SR. The focus of this paper is on SR especially for the synthesis of quantitative data from primary research studies that examines the effectiveness of healthcare interventions. To activate evidence-based nursing care in various healthcare settings, the best and available scientific evidence are essential components. This paper will include some examples to promote understandings. Copyright © 2016. Published by Elsevier B.V.

Communicating environmental exposure results and health information in a community-based participatory research study.

PubMed

Claudio, Luz; Gilmore, Jalisa; Roy, Mohana; Brenner, Barbara

2018-06-25

Communicating results to participants is a fundamental component of community-based participatory research (CBPR). However, in environmental exposure studies this is not always practiced, partly due to ethical concerns of communicating results that have unknown clinical significance. Growing Up Healthy was a community-based participatory research study that sought to understand the relationship between environmental exposures to phthalates and early puberty in young girls. After in-depth consultation with a Community Advisory Board, study investigators provided group summary results of phthalate exposures and related health information to the parents of study participants. Parents' comprehension and knowledge of the health information provided was then assessed through questionnaires. After receiving the information from the research team, responders were able to correctly answer comprehension questions about phthalate exposures in their community, were able to identify ways to reduce exposure to phthalates, and indicated plans to do so. Questionnaires revealed that parents wanted more information on phthalates, and that children's environmental health was an important concern. We conclude that effective communication of exposure results of unknown clinical significance to participants in environmental health studies can be achieved by providing group summary results and actionable health information. Results suggest that there was an improvement in knowledge of environmental health and in risk reduction behaviors in our study population.

An archiving system for Planetary Mapping Data - Availability of derived information and knowledge in Planetary Science!

NASA Astrophysics Data System (ADS)

Nass, A.

2017-12-01

Since the late 1950s a huge number of planetary missions started to explore our solar system. The data resulting from this robotic exploration and remote sensing varies in data type, resolution and target. After data preprocessing, and referencing, the released data are available for the community on different portals and archiving systems, e.g. PDS or PSA. One major usage for these data is mapping, i.e. the extraction and filtering of information by combining and visualizing different kind of base data. Mapping itself is conducted either for mission planning (e.g. identification of landing site) or fundamental research (e.g. reconstruction of surface). The mapping results for mission planning are directly managed within the mission teams. The derived data for fundamental research - also describable as maps, diagrams, or analysis results - are mainly project-based and exclusively available in scientific papers. Within the last year, first steps have been taken to ensure a sustainable use of these derived data by finding an archiving system comparable to the data portals, i.e. reusable, well-documented, and sustainable. For the implementation three tasks are essential. Two tasks have been treated in the past 1. Comparability and interoperability has been made possible by standardized recommendations for visual, textual, and structural description of mapping data. 2. Interoperability between users, information- and graphic systems is possible by templates and guidelines for digital GIS-based mapping. These two steps are adapted e.g. within recent mapping projects for the Dawn mission. The third task hasn`t been implemented thus far: Establishing an easily detectable and accessible platform that holds already acquired information and published mapping results for future investigations or mapping projects. An archive like this would support the scientific community significantly by a constant rise of knowledge and understanding based on recent discussions within Information Science and Management, and Data Warehousing. This contribution describes the necessary map archive components that have to be considered for an efficient establishment and user-oriented accessibility. It will be described how already existing developments could be used, and which components will have to be developed yet.

Research Frontiers in Bioinspired Energy: Molecular-Level Learning from Natural Systems: A Workshop

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zolandz, Dorothy

An interactive, multidisciplinary, public workshop, organized by a group of experts in biochemistry, biophysics, chemical and biomolecular engineering, chemistry, microbial metabolism, and protein structure and function, was held on January 6-7, 2011 in Washington, DC. Fundamental insights into the biological energy capture, storage, and transformation processes provided by speakers was featured in this workshop which included topics such as microbes living in extreme environments such as hydrothermal vents or caustic soda lakes (extremophiles) provided a fascinating basis for discussing the exploration and development of new energy systems. Breakout sessions and extended discussions among the multidisciplinary groups of participants in themore » workshop fostered information sharing and possible collaborations on future bioinspired research. Printed and web-based materials that summarize the committee's assessment of what transpired at the workshop were prepared to advance further understanding of fundamental chemical properties of biological systems within and between the disciplines. In addition, webbased materials (including two animated videos) were developed to make the workshop content more accessible to a broad audience of students and researchers working across disciplinary boundaries. Key workshop discussion topics included: Exploring and identifying novel organisms; Identifying patterns and conserved biological structures in nature; Exploring and identifying fundamental properties and mechanisms of known biological systems; Supporting current, and creating new, opportunities for interdisciplinary education, training, and outreach; and Applying knowledge from biology to create new devices and sustainable technology.« less

School-Based Fundamental-Motor-Skill Intervention for Children With Autism-Like Characteristics: An Exploratory Study.

PubMed

Bremer, Emily; Lloyd, Meghann

2016-01-01

The purpose of this pilot study was to demonstrate the impact of a fundamental-motor-skill (FMS) intervention on the motor skills of 3- to 7-year-old children with autism-like characteristics in an early intervention classroom. A secondary purpose was to qualitatively assess the impact of the program as described by the classroom's special education teacher. All children in the classroom (N = 5) took part in an FMS intervention for two 6-wk blocks (fall 2013 and winter 2014). Motor-skill proficiency and social skills were assessed at 3 times: baseline, after Block 1 of the intervention, and after Block 2 of the intervention. In addition, an interview was conducted with the classroom teacher after Assessment 3 to draw further insights into the relative success and impact of the program. Results were analyzed through a visual analysis and presented individually. They indicated improvements in the participants' individual FMS and social-skill scores, possible improvements in declarative knowledge, and an increase in the special education teacher's readiness to teach FMS; further research with larger, controlled samples is warranted.

Molecular Biology and Biotechnology of Bacteriophage

NASA Astrophysics Data System (ADS)

Onodera, Kazukiyo

The development of the molecular biology of bacteriophage such as T4, lambda and filamentous phages was described and the process that the fundamental knowledge obtained in this field has subsequently led us to the technology of phage display was introduced.

THE US ENVIRONMENTAL PROTECTION AGENCY'S MONITORING AND ASSESSMENT PROGRAM

EPA Science Inventory

A scientifically rigorous determination of the condition of an aquatic resource is fundamental to all subsequent research, modeling, protection, and restoration issues. Environmental risk characterization is predicated on knowledge of condition and the rate at which that conditio...

Space Shuttle Projects

NASA Image and Video Library

1993-10-01

Designed by the mission crew members, the STS-61 crew insignia depicts the astronaut symbol superimposed against the sky with the Earth underneath. Also seen are two circles representing the optical configuration of the Hubble Space Telescope (HST). Light is focused by reflections from a large primary mirror and a smaller secondary mirror. The light is analyzed by various instruments and, according to the crew members, brings to us on Earth knowledge about planets, stars, galaxies and other celestial objects, allowing us to better understand the complex physical processes at work in the universe. The Space Shuttle Endeavour is also represented as the fundamental tool that allows the crew to perform the first servicing of the Hubble Space Telescope so its scientific deep space mission may be extended for several years to come. The overall design of the emblem, with lines converging to a high point, is also a symbolic representation of the large-scale Earth-based effort which involves space agencies, industry, and the universities to reach goals of knowledge and perfection.

Young Children Bet On Their Numerical Skills: Metacognition in the Numerical Domain

PubMed Central

Vo, Vy A.; Li, Rosa; Kornell, Nate; Pouget, Alexandre; Cantlon, Jessica F.

2014-01-01

Metacognition, the ability to assess one’s own knowledge, has been targeted as a critical learning mechanism in mathematics education. Yet, the early childhood origins of metacognition have proven difficult to study. Using a novel nonverbal task and a comprehensive set of metacognitive measures, we provide the strongest evidence to date that young children are metacognitive. We show that children as young as 5 years make metacognitive “bets” on their numerical discriminations in a wagering task. However, contrary to previous reports from adults, children’s metacognition proved to be domain-specific: children’s metacognition in the numerical domain was unrelated to their metacognition in another domain (emotion discrimination). Moreover, children’s metacognitive ability in only the numerical domain predicted their school-based mathematics knowledge. The data provide novel evidence that metacognition is a fundamental, domain-dependent cognitive ability in children. The findings have implications for theories of uncertainty and reveal new avenues for training metacognition in children. PMID:24973137

An improved association-mining research for exploring Chinese herbal property theory: based on data of the Shennong's Classic of Materia Medica.

PubMed

Jin, Rui; Lin, Zhi-jian; Xue, Chun-miao; Zhang, Bing

2013-09-01

Knowledge Discovery in Databases is gaining attention and raising new hopes for traditional Chinese medicine (TCM) researchers. It is a useful tool in understanding and deciphering TCM theories. Aiming for a better understanding of Chinese herbal property theory (CHPT), this paper performed an improved association rule learning to analyze semistructured text in the book entitled Shennong's Classic of Materia Medica. The text was firstly annotated and transformed to well-structured multidimensional data. Subsequently, an Apriori algorithm was employed for producing association rules after the sensitivity analysis of parameters. From the confirmed 120 resulting rules that described the intrinsic relationships between herbal property (qi, flavor and their combinations) and herbal efficacy, two novel fundamental principles underlying CHPT were acquired and further elucidated: (1) the many-to-one mapping of herbal efficacy to herbal property; (2) the nonrandom overlap between the related efficacy of qi and flavor. This work provided an innovative knowledge about CHPT, which would be helpful for its modern research.

Update on pediatric sepsis: a review.

PubMed

Kawasaki, Tatsuya

2017-01-01

Sepsis is one of the leading causes of mortality among children worldwide. Unfortunately, however, reliable evidence was insufficient in pediatric sepsis and many aspects in clinical practice actually depend on expert consensus and some evidence in adult sepsis. More recent findings have given us deep insights into pediatric sepsis since the publication of the Surviving Sepsis Campaign guidelines 2012. New knowledge was added regarding the hemodynamic management and the timely use of antimicrobials. Quality improvement initiatives of pediatric "sepsis bundles" were reported to be successful in clinical outcomes by several centers. Moreover, a recently published global epidemiologic study (the SPROUT study) did not only reveal the demographics, therapeutic interventions, and prognostic outcomes but also elucidated the inappropriateness of the current definition of pediatric sepsis. With these updated knowledge, the management of pediatric sepsis would be expected to make further progress. In addition, it is meaningful that the fundamental data on which future research should be based were established through the SPROUT study.

Students’ Cognitive Abilities in Plant Anatomy Practical Work

NASA Astrophysics Data System (ADS)

Setiono, S.; Rustaman, N. Y.; Rahmat, A.; Anggraeni, S.

2017-09-01

Cognitive abilities is fundamental for the students, as it is closely related to higher thinking skills such as the ability to think critically, creatively, and problem solving. This descriptive study aims to investigate the cognitive abilities of biology prospective teachers in the course of Plant Anatomy Practicum based on the cognitive process dimension and dimensions of knowledge the using the framework of Revision of Bloom taxonomy. A number of biology prospective teachers was involved in this study (n=42). The instrument used to collect data for students’ cognitive process mastery in the form of multiple choice with 5 options. Research finding shows that the average student’s cognitive ability is 68.10. The acquisition of knowledge mastery of cognitive ability is still under the criterion of mastery in the course of the Plant Anatomy Practicum (75). Validity and reliability of the instrument (0,71) and (0,81). It is necessary to design lecture programs both in the class and laboratory to develop student’ cognitive abilities.

Architectures for paediatric palliative care: how to improve quality of life and environmental well-being.

PubMed

Gola, Marco; Francalanza, Paolo Carlo; Galloni, Giulio; Pagella, Bianca; Capolongo, Stefano

2016-01-01

The influence of the environment on wellness, not only for patients themselves but for all care-givers as well, refers to the humanisation principles of spaces of care. Commencing with an analysis of existing paediatric hospices, the paper examines design suggestions for prosthetic environments, considered as a fundamental component in the healing process. A prosthetic environment can be created only through a specific knowledge of the real needs of users. Therefore, some scholars have conducted research work for defining the best practices for healing environments, supported by an assessment and comparison of case studies. The methodology is based on two phases: the first is based on interviews with experts in hospice design and management and the second, through the application of a questionnaire to several users. Discussion and Results. The output of the work is the achievement of a logical, sequential and participatory broad-spectrum process in the design of health facilities in order to cause a sustainable awareness in paediatric hospices. Starting from the research work, it is necessary to define a scientific method for implementing knowledge on health, psychological, perceptual and behavioural needs to contribute towards proper planning for meeting the real requirements of users.

Development of the biology card sorting task to measure conceptual expertise in biology.

PubMed

Smith, Julia I; Combs, Elijah D; Nagami, Paul H; Alto, Valerie M; Goh, Henry G; Gourdet, Muryam A A; Hough, Christina M; Nickell, Ashley E; Peer, Adrian G; Coley, John D; Tanner, Kimberly D

2013-01-01

There are widespread aspirations to focus undergraduate biology education on teaching students to think conceptually like biologists; however, there is a dearth of assessment tools designed to measure progress from novice to expert biological conceptual thinking. We present the development of a novel assessment tool, the Biology Card Sorting Task, designed to probe how individuals organize their conceptual knowledge of biology. While modeled on tasks from cognitive psychology, this task is unique in its design to test two hypothesized conceptual frameworks for the organization of biological knowledge: 1) a surface feature organization focused on organism type and 2) a deep feature organization focused on fundamental biological concepts. In this initial investigation of the Biology Card Sorting Task, each of six analytical measures showed statistically significant differences when used to compare the card sorting results of putative biological experts (biology faculty) and novices (non-biology major undergraduates). Consistently, biology faculty appeared to sort based on hypothesized deep features, while non-biology majors appeared to sort based on either surface features or nonhypothesized organizational frameworks. Results suggest that this novel task is robust in distinguishing populations of biology experts and biology novices and may be an adaptable tool for tracking emerging biology conceptual expertise.

Predicting Human Protein Subcellular Locations by the Ensemble of Multiple Predictors via Protein-Protein Interaction Network with Edge Clustering Coefficients

PubMed Central

Du, Pufeng; Wang, Lusheng

2014-01-01

One of the fundamental tasks in biology is to identify the functions of all proteins to reveal the primary machinery of a cell. Knowledge of the subcellular locations of proteins will provide key hints to reveal their functions and to understand the intricate pathways that regulate biological processes at the cellular level. Protein subcellular location prediction has been extensively studied in the past two decades. A lot of methods have been developed based on protein primary sequences as well as protein-protein interaction network. In this paper, we propose to use the protein-protein interaction network as an infrastructure to integrate existing sequence based predictors. When predicting the subcellular locations of a given protein, not only the protein itself, but also all its interacting partners were considered. Unlike existing methods, our method requires neither the comprehensive knowledge of the protein-protein interaction network nor the experimentally annotated subcellular locations of most proteins in the protein-protein interaction network. Besides, our method can be used as a framework to integrate multiple predictors. Our method achieved 56% on human proteome in absolute-true rate, which is higher than the state-of-the-art methods. PMID:24466278

Another development with Women.

PubMed

Ahooja-patel, K

1982-01-01

The objective of this discussion of "Another Development with Women" is to add some thoughts to the scientific approach, which combines survey techniques and computer style data analysis (measurability, detachment, and objectivity). Its purpose is to tilt the balance of the development process a bit further towards women, and it proposes to introduce another element into the discussion on development with women--that of experiential knowledge (knowledge based on collective experience). Women researchers have a double consciousness, similar to that of the black or other discriminated minority, an awareness of the motives and strategies of the oppressor as well as the inner view of the oppressed. To find some answers to the question why the development debate is sometimes obscure, sometimes sterile, and usually frustrating, and to understand why the goals of development remain distant oases, it is necessary to turn attention to the actual contribution women are making to development. Fundamentally, most of women's activities seem to fall outside the definition of "gainful employment." The activities are labeled "nonmarket" or "nonmonetized" activities. It is the differential between work and creativity that fundamentally affects women and erodes their economic and social status. Another unperceived dimension to women's work, which further conceals their efforts and prevents them from surfacing, is the fact that until recently socioeconomic series and indicators were not desegregated by sex. Consequently, the available data on key economic and social questions could not answer the fundamental questions of where are women working, in what numbers, in which activities, and at what wage levels. During the last 2 years some global data for an international information base on women has become available, and the new data will make it possible to follow much more closely, and on a comparative basis for a much larger number of countries, new developments concerning women's employment, working conditions, and their contributions to society. To gain some insights into the processes of development, 4 different economic and social indicators are examined: agriculture, industry, health, and education. Also examined are women's main roles in food production, industrial work, health provision, and education. It is clear that in any theory of power and its distribution, women bear the brunt of inequality in terms of income and rewards, assets, and resources. Another Development will have to find ways by which the unexplored creative energies of women are released.

Knowledge-based assistance for science visualization and analysis using large distributed databases

NASA Technical Reports Server (NTRS)

Handley, Thomas H., Jr.; Jacobson, Allan S.; Doyle, Richard J.; Collins, Donald J.

1993-01-01

Within this decade, the growth in complexity of exploratory data analysis and the sheer volume of space data require new and innovative approaches to support science investigators in achieving their research objectives. To date, there have been numerous efforts addressing the individual issues involved in inter-disciplinary, multi-instrument investigations. However, while successful in small scale, these efforts have not proven to be open and scalable. This proposal addresses four areas of significant need: scientific visualization and analysis; science data management; interactions in a distributed, heterogeneous environment; and knowledge-based assistance for these functions. The fundamental innovation embedded with this proposal is the integration of three automation technologies, namely, knowledge-based expert systems, science visualization and science data management. This integration is based on concept called the DataHub. With the DataHub concept, NASA will be able to apply a more complete solution to all nodes of a distributed system. Both computation nodes and interactive nodes will be able to effectively and efficiently use the data services (address, retrieval, update, etc.) with a distributed, interdisciplinary information system in a uniform and standard way. This will allow the science investigators to concentrate on their scientific endeavors, rather than to involve themselves in the intricate technical details of the systems and tools required to accomplish their work. Thus, science investigators need not be programmers. The emphasis will be on the definition and prototyping of system elements with sufficient detail to enable data analysis and interpretation leading to publishable scientific results. In addition, the proposed work includes all the required end-to-end components and interfaces to demonstrate the completed concept.

Knowledge-based assistance for science visualization and analysis using large distributed databases

NASA Technical Reports Server (NTRS)

Handley, Thomas H., Jr.; Jacobson, Allan S.; Doyle, Richard J.; Collins, Donald J.

1992-01-01

Within this decade, the growth in complexity of exploratory data analysis and the sheer volume of space data require new and innovative approaches to support science investigators in achieving their research objectives. To date, there have been numerous efforts addressing the individual issues involved in inter-disciplinary, multi-instrument investigations. However, while successful in small scale, these efforts have not proven to be open and scaleable. This proposal addresses four areas of significant need: scientific visualization and analysis; science data management; interactions in a distributed, heterogeneous environment; and knowledge-based assistance for these functions. The fundamental innovation embedded within this proposal is the integration of three automation technologies, namely, knowledge-based expert systems, science visualization and science data management. This integration is based on the concept called the Data Hub. With the Data Hub concept, NASA will be able to apply a more complete solution to all nodes of a distributed system. Both computation nodes and interactive nodes will be able to effectively and efficiently use the data services (access, retrieval, update, etc.) with a distributed, interdisciplinary information system in a uniform and standard way. This will allow the science investigators to concentrate on their scientific endeavors, rather than to involve themselves in the intricate technical details of the systems and tools required to accomplish their work. Thus, science investigators need not be programmers. The emphasis will be on the definition and prototyping of system elements with sufficient detail to enable data analysis and interpretation leading to publishable scientific results. In addition, the proposed work includes all the required end-to-end components and interfaces to demonstrate the completed concept.

Research into the development of a knowledge acquisition taxonomy

NASA Technical Reports Server (NTRS)

Fink, Pamela K.; Herren, L. Tandy

1991-01-01

The focus of the research was on the development of a problem solving taxonomy that can support and direct the knowledge engineering process during the development of an intelligent tutoring system. The results of the research are necessarily general. Being only a small initial attempt at a fundamental problem in artificial intelligence and cognitive psychology, the process has had to be bootstrapped and the results can only provide pointers to further, more formal research designs.

Philosophical Foundations of Zwicky's Morphological Approach in Science

NASA Astrophysics Data System (ADS)

Rudnicki, Konrad

Fritz Zwicky as a conscious Goetheanist. Johann Wolfgang Goethe as a natural philosopher and methodologist. Goetheanist theory of knowledge — a theory essentially different from the theory of Kant, from which the contemporary concept of paradigms has originated. Pre-scientific character of theory of knowledge. The principal thought experiment. The role of thinking in Goetheanism. Fundamental phenomena. Morphological approach. The shape (µo ) of a problem. Morphological box. Individual hypothesis versus classes of hypotheses. Theory and reality.

[Biomedical publications in Spain on debate (II): the on-going 'revolutions' and their application to neurological journals].

PubMed

González de Dios, J; Sempere, A P; Aleixandre-Benavent, R

To debate about the application of on-going 'revolutions' in medical knowledge to Spanish neurological journals in the 21st century. This article reviews the current status of five revolutions in the field of health sciences, in general, and in neurological sciences, in particular: 1) the knowledge revolution: to translate the scientific investigation to the patient, with knowledge needs-driven research agenda with founder commissioning research to answer questions posed by clinicians, managers and patients, and systematic and critical appraisal reviews as the creator of quality improved knowledge; 2) the evidence based medicine revolution: the pyramid information of '4S', with systems (guidelines and computerized decision support systems), synopses (secondary journals), syntheses (systematic reviews and meta-analysis) and studies (original studies published in journals); 3) the web revolution: the possibility of dissemination of biomedical documentation by means of the Internet network are producing changes in the traditional way of conceiving scientific publication; the Internet represents a great advantage for investigation and also for clinical practice, since it permits free, universal access to databases and the interchange of texts, images and videos; 4) the open access revolution: to take full control over all operations related to the process of publish (to create, publish, communicate, distribute, reproduce and transform) with no need of any intermediaries, and to transform fundamental aspects concerning the circulation of knowledge, its use and availability; and 5) the librarian revolution: the project of a Virtual Health Library in Spain as a tool to access and disseminate scientific and technical knowledge on health through the Internet.

Mountain treelines: A roadmap for research orientation

USGS Publications Warehouse

Malanson, George P.; Resler, Lynn M.; Bader, Maaike Y.; Holtmeier, Fredrich-Karl; Butler, David R.; Weiss, Daniel J.; Daniels, Lori D.; Fagre, Daniel B.

2011-01-01

For over 100 years, mountain treelines have been the subject of varied research endeavors and remain a strong area of investigation. The purpose of this paper is to examine aspects of the epistemology of mountain treeline research-that is, to investigate how knowledge on treelines has been acquired and the changes in knowledge acquisition over time, through a review of fundamental questions and approaches. The questions treeline researchers have raised and continue to raise have undoubtedly directed the current state of knowledge. A continuing, fundamental emphasis has centered on seeking the general cause of mountain treelines, thus seeking an answer to the question, "What causes treeline?" with a primary emphasis on searching for ecophysiological mechanisms of low-temperature limitation for tree growth and regeneration. However, treeline research today also includes a rich literature that seeks local, landscape-scale causes of treelines and reasons why treelines vary so widely in three-dimensional patterns from one location to the next, and this approach and some of its consequences are elaborated here. In recent years, both lines of research have been motivated greatly by global climate change. Given the current state of knowledge, we propose that future research directions focused on a spatial approach should specifically address cross-scale hypotheses using statistics and simulations designed for nested hierarchies; these analyses will benefit from geographic extension of treeline research.

a Continual Engagement Approach Through Gis-Mcda Conflict Resolution of Loggerhead Sea Turtle Bycatch in Mexico

NASA Astrophysics Data System (ADS)

Bojórquez-Tapia, L. A.

2015-12-01

Continual engagement is an approach that emphasizes of uninterrupted interaction with the stakeholders with the purpose of fully integrating their knowledge into policymaking process. It focuses on the creation of hybrid scientific-local knowledge highly relevant to community and policy makers needs, while balancing the power asymmetries among stakeholders. Hence, it presupposes a capacity for a continuous revision and adjustment of the analyses that support the policymaking process. While continual engagement implies a capacity for enabling an effective communication, translation and mediation of knowledge among the diverse stakeholders, experts and policymakers, it also means keeping a close eye out for how knowledge evolves and how new data and information is introduced along a policymaking process. Through a case study, the loggerhead sea turtle (Caretta caretta) fishing bycatch in Mexico, a geographical information system-multicriteria modeling (GIS-MCDA) approach is presented to address the challenges of implementing continual engagement in conflict resolution processes. The GIS-MCDA combined the analytical hierarchy process (AHP) and compromise programming (CP) to generate consensus regarding the spatial pattern of conflicts. The AHP was fundamental for synthesizing the different sources of knowledge into a geospatial model. In particular, the AHP enabled the assess the salience, legitimacy, and credibility of the information produced for all involved. Results enabled the development of specific policies based upon an assessment of the risk of the loggerhead population to different levels of fishing bycatch, and the needs of the fishing communities in the region.

Student Teachers' Approaches to Teaching Biological Evolution

ERIC Educational Resources Information Center

Borgerding, Lisa A.; Klein, Vanessa A.; Ghosh, Rajlakshmi; Eibel, Albert

2015-01-01

Evolution is fundamental to biology and scientific literacy, but teaching high school evolution is often difficult. Evolution teachers face several challenges including limited content knowledge, personal conflicts with evolution, expectations of resistance, concerns about students' conflicts with religion, and curricular constraints. Evolution…

Bias in the Counseling Process: How to Recognize and Avoid It.

ERIC Educational Resources Information Center

Morrow, Kelly A.; Deidan, Cecilia T.

1992-01-01

Notes that counselors' vulnerability to inferential bias during counseling process may result in misdiagnosis and improper interventions. Discusses these inferential biases: availability and representativeness heuristics; fundamental attribution error; anchoring, prior knowledge, and labeling; confirmatory hypothesis testing; and reconstructive…

78 FR 28275 - Office of Commercial Space Transportation; Safety Approval Performance Criteria

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-14

... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration Office of Commercial Space... classroom and hypobaric chamber training for crew and space flight participants to experience and demonstrate knowledge of the following through testing: Understand fundamental principles of the atmosphere...

Cardiovascular Effects of Air Pollution Clinical and Public Health Implications: Knowledge Gaps and Opportunities

EPA Science Inventory

“Healthy Heart: Air Pollution and Cardiovascular Health” is a webinar presentation designed to introduce the fundamental epidemiological associations between ambient air pollution and cardiovascular health. Despite the phenomenal improvement in air quality across th...

Mercury Detection with Gold Nanoparticles: Investigating Fundamental Phenomena and Expanding Applications

NASA Astrophysics Data System (ADS)

Crosby, Jeffrey Scott

Mercury is a pollutant of grave concern with well documented neurological and developmental health impacts. Better sensing methodology would improve detection and control of mercury and thus reduce its health burden. Gold nanoparticles provide a sensing medium with potential advantages in sensitivity, selectivity, robustness, and cost over established techniques. Mercury readily adsorbs onto the surface of the gold changing the localized surface plasmon resonance which is measured as a shift in the peak optical absorbance wavelength. This shift is dependent on the mercury concentration and predictable with classical electromagnetism. This work investigates some of the fundamental relationships driving sensor response. The effects of mass transfer and surface kinetics on mercury/gold nanoparticle adsorption are determined with analytical models and experimental results based on impinging flow geometry. To decouple mass transfer and surface kinetics adsorption, electrical analogy models are constructed and fit to the experimental data. The models can account for variations in flow conditions and surface coatings on the nanoparticles. These models are generalizable to other systems. Results from these fundamental investigations are used to improve and extend sensor performance. The time response or collection efficiency is optimized depending on system requirements. Using the knowledge gained, the applicability of gold nanoparticle mercury sensors is extended to a fiber optic based system and aqueous detection. Nanorods deposited on the surface of a fiber optic cable have a linear response with concentration and are able to detect mercury down to 1.0 mug/m3. The modification of an established oxidation/reduction scheme for use with the sensor allows for the detection of ionic and organic mercury from water samples which ordinarily would not be reactive with gold nanoparticles. The aqueous sensor was able to detect mercury below the EPA's drinking water limit.

The Visual Geophysical Exploration Environment: A Multi-dimensional Scientific Visualization

NASA Astrophysics Data System (ADS)

Pandya, R. E.; Domenico, B.; Murray, D.; Marlino, M. R.

2003-12-01

The Visual Geophysical Exploration Environment (VGEE) is an online learning environment designed to help undergraduate students understand fundamental Earth system science concepts. The guiding principle of the VGEE is the importance of hands-on interaction with scientific visualization and data. The VGEE consists of four elements: 1) an online, inquiry-based curriculum for guiding student exploration; 2) a suite of El Nino-related data sets adapted for student use; 3) a learner-centered interface to a scientific visualization tool; and 4) a set of concept models (interactive tools that help students understand fundamental scientific concepts). There are two key innovations featured in this interactive poster session. One is the integration of concept models and the visualization tool. Concept models are simple, interactive, Java-based illustrations of fundamental physical principles. We developed eight concept models and integrated them into the visualization tool to enable students to probe data. The ability to probe data using a concept model addresses the common problem of transfer: the difficulty students have in applying theoretical knowledge to everyday phenomenon. The other innovation is a visualization environment and data that are discoverable in digital libraries, and installed, configured, and used for investigations over the web. By collaborating with the Integrated Data Viewer developers, we were able to embed a web-launchable visualization tool and access to distributed data sets into the online curricula. The Thematic Real-time Environmental Data Distributed Services (THREDDS) project is working to provide catalogs of datasets that can be used in new VGEE curricula under development. By cataloging this curricula in the Digital Library for Earth System Education (DLESE), learners and educators can discover the data and visualization tool within a framework that guides their use.

A Fundamental Approach to Developing Aluminium based Bulk Amorphous Alloys based on Stable Liquid Metal Structures and Electronic Equilibrium - 154041

DTIC Science & Technology

2017-03-28

AFRL-AFOSR-JP-TR-2017-0027 A Fundamental Approach to Developing Aluminium-based Bulk Amorphous Alloys based on Stable Liquid -Metal Structures and...to 16 Dec 2016 4.  TITLE AND SUBTITLE A Fundamental Approach to Developing Aluminium-based Bulk Amorphous Alloys based on Stable Liquid -Metal...including Al, Cu, Ni, Zr, Mg, Pd, Ga , Ca. Many new Al-based amorphous alloys were found within the numerous alloy systems studied in this project, and

Synthetic immunology: modulating the human immune system.

PubMed

Geering, Barbara; Fussenegger, Martin

2015-02-01

Humans have manipulated the immune system to dampen or boost the immune response for thousands of years. As our understanding of fundamental immunology and biotechnological methodology accumulates, we can capitalize on this combined knowledge to engineer biological devices with the aim of rationally manipulating the immune response. We address therapeutic approaches based on the principles of synthetic immunology that either ameliorate disorders of the immune system by interfering with the immune response, or improve diverse pathogenic conditions by exploiting immune cell effector functions. We specifically highlight synthetic proteins investigated in preclinical and clinical trials, summarize studies that have used engineered immune cells, and finish with a discussion of possible future therapeutic concepts. Copyright © 2014 Elsevier Ltd. All rights reserved.

Dynamic torsional response analysis of mechanoluminescent paint and its application to non-contacting automotive torque transducers

NASA Astrophysics Data System (ADS)

Kim, Gi-Woo; Kim, Ji-Sik

2014-01-01

This paper presents the result of a preliminary experimental study on the dynamic torsional response analysis of mechanoluminescent (ML) paint for potential development as a new type of non-contacting torque transducer. The torsional torque applied to a transmission shaft is measured by sensing the ML intensity emitting from an ML paint coating a transmission shaft. This study provides the fundamental knowledge for the development of new non-contacting torque sensing technology based on the ML intensity detection. The proposed measurement principle appears to offer potential applications in automotive torque measurement systems, even though the loading rate-dependent characteristics of the ML intensity needs to be examined further.

Comparative and quantitative analysis of white light-emitting diodes and other lamps used for home illumination

NASA Astrophysics Data System (ADS)

Rubinger, Rero Marques; da Silva, Edna Raimunda; Pinto, Daniel Zaroni; Rubinger, Carla Patrícia Lacerda; Oliveira, Adhimar Flávio; da Costa Bortoni, Edson

2015-01-01

We compared the photometric and radiometric quantities in the visible, ultraviolet, and infrared spectra of white light-emitting diodes (LEDs), incandescent light bulbs and a compact fluorescent lamp used for home illumination. The color-rendering index and efficiency-related quantities were also used as auxiliary tools in this comparison. LEDs have a better performance in all aspects except for the color-rendering index, which is better with an incandescent light bulb. Compact fluorescent lamps presented results that, to our knowledge, do not justify their substitution for the incandescent light bulb. The main contribution of this work is an approach based on fundamental quantities to evaluate LEDs and other light sources.

Sulfur as a Signaling Nutrient Through Hydrogen Sulfide

PubMed Central

Kabil, Omer; Vitvitsky, Victor; Banerjee, Ruma

2015-01-01

Hydrogen sulfide (H2S) has emerged as an important signaling molecule with beneficial effects on various cellular processes affecting, for example, cardiovascular and neurological functions. The physiological importance of H2S is motivating efforts to develop strategies for modulating its levels. However, advancement in the field of H2S-based therapeutics is hampered by fundamental gaps in our knowledge of how H2S is regulated, its mechanism of action, and its molecular targets. This review provides an overview of sulfur metabolism; describes recent progress that has shed light on the mechanism of H2S as a signaling molecule; and examines nutritional regulation of sulfur metabolism, which pertains to health and disease. PMID:25033061

Time discounting and criminal behavior

PubMed Central

Åkerlund, David; Golsteyn, Bart H. H.; Grönqvist, Hans; Lindahl, Lena

2016-01-01

One of the most basic predictions of almost any model of crime is that individual time preferences matter. However, empirical evidence on this fundamental property is essentially nonexistent. To our knowledge, this paper provides the first pieces of evidence on the link between time discounting and crime. We use a unique dataset that combines a survey-based measure of time discount rates (at age 13) with detailed longitudinal register data on criminal behavior spanning over 18 y. Our results show that individuals with short time horizons have a significantly higher risk of criminal involvement later in life. The magnitude of the relationship is substantial and corresponds to roughly one-third of the association between intelligence and crime. PMID:27185950

The impact of science and technology on the civilization.

PubMed

Arber, Werner

2009-01-01

The rapid increase of available scientific knowledge is largely due to the introduction of novel research strategies. The application of these strategies, both in fundamental and in translational scientific research, leads to bursts of technological innovations. In order to fulfill the justified public request for sustainability of technological innovations that contribute to the shaping of the future, increasing attention should be given to science-based technology and policy assessment. These requests are illustrated by benefit/risk evaluations of relevance for the use of genetic engineering as an efficient and effective research strategy. Expected benefits of a responsibly planned introduction of GM crops are outlined as a prospective example for the guiding theme "Biotechnology for sustainability of human society".

Collaborative Research: Fundamental studies of plasma control using surface embedded electronic devices

DOE Office of Scientific and Technical Information (OSTI.GOV)

Raja, Laxminarayan L.; PanneerChelvam, PremKumar; Levko, Dimtry

2016-02-26

The proposed study will investigate the effect of active electron injection of from electrode surfaces To the best of our knowledge, no such a study has ever been attempted even though it could lead to the formation of whole new classes of plasma based devices and systems. We are motivated by recent articles and simple theory which gives strong reason to believe that embedded electronic devices can be used to exert control over the SEE coefficient of semiconductor surfaces (and maybe other surface types as well). Furthermore, the research will explore how such sub-surface electronic devices can best be usedmore » to exert control over an associated plasma.« less

On the representation matrices of the spin permutation group. [for atomic and molecular electronic structures

NASA Technical Reports Server (NTRS)

Wilson, S.

1977-01-01

A method is presented for the determination of the representation matrices of the spin permutation group (symmetric group), a detailed knowledge of these matrices being required in the study of the electronic structure of atoms and molecules. The method is characterized by the use of two different coupling schemes. Unlike the Yamanouchi spin algebraic scheme, the method is not recursive. The matrices for the fundamental transpositions can be written down directly in one of the two bases. The method results in a computationally significant reduction in the number of matrix elements that have to be stored when compared with, say, the standard Young tableaux group theoretical approach.

Raising standards of clinical practice--the fundamental issue of effective nursing practice.

PubMed

Kitson, A L

1987-05-01

The proposition put forward in this paper is that standards of nursing practice can only be assured if the profession is able to find ways of responding to the intuitions and gut reactions of its practitioners. Rather than deny them, nurses have to know how to test and thus legitimize them. Such a validation process demands more clinically based nursing research projects and the proliferation of arrangements such as clinical nursing practice units. It is further argued that by linking the intuitive and rational aspects of nursing in this way the profession is in a better position not only to fulfil its societal obligations but also to build up its own knowledge and skills.

Amino acid-assisted synthesis of zinc oxide nanostructures

NASA Astrophysics Data System (ADS)

Singh, Baljinder; Moudgil, Lovika; Singh, Gurinder; Kaura, Aman

2018-05-01

In this manuscript we have used experimental approach that can provide a fundamental knowledge about the role played by biomolecules in designing the shape of nanostructure (NS) at a microscopic level. The three different amino acids (AAs) - Arginine (Arg), Aspartic acid (Asp) and Histidine (His) coated Zinc oxide (ZnO) NSs to explain the growth mechanism of nanoparticles of different shapes. Based on the experimental methodology we propose that AA-ZnO (Asp and Arg) nanomaterials could form of rod like configuration and His-ZnO NPs could form tablet like configuration. The synthesized samples are characterized using transmission electron microscopy (TEM) and X-ray diffraction (XRD). Results reveal that AAs are responsible for formation of different NSs

Identification of knowledge gaps in neurosurgery using a validated self-assessment examination: differences between general and spinal neurosurgeons.

PubMed

Sheehan, Jason; Starke, Robert M; Pouratian, Nader; Litvack, Zachary

2013-11-01

The practice of neurosurgery requires fundamental knowledge base. Residency training programs and continuing medical education courses are designed to teach relevant neurosurgical principles. Nevertheless, knowledge gaps exist for neurosurgeons and may be different between cohorts of neurosurgeons. The Self-Assessment in Neurological Surgery (SANS) General Examination and Spine Examination are online educational tools for lifelong learning and maintenance of certification. This study examines the gaps in knowledge of spinal neurosurgeons and general neurosurgeons taking SANS. From 2008 to 2010, a total of 165 spinal neurosurgeons completed the 243 available questions of the SANS Spine Examination. Over that same time frame, 993 general neurosurgeons completed the SANS General Spine Examination. Mean scores were calculated and assessed according to 18 major neurosurgical knowledge disciplines. Statistical analysis was carried out to evaluate for significant knowledge gaps among all users and significant differences in performance between spinal neurosurgeons and their general neurosurgeon counterparts. The mean overall examination score was 87.4% ± 7.5% for spinal neurosurgeons and 71.5% ± 8.9% for general neurosurgeons (P < 0.001). Of the 18 major knowledge categories in SANS, spinal neurosurgeons (n = 165) answered questions incorrectly 15% or greater of the time in five of the categories. The categories of lower performance for spinal neurosurgeons were cerebrovascular, anesthesia and critical care, general clinical, tumor, and trauma. For general neurosurgeons (n = 993), the five knowledge categories with lowest performance were cerebrovascular, epilepsy, peripheral nerve, trauma, and radiosurgery. Although spinal neurosurgeons and general neurosurgeons shared some areas of decreased performance including trauma and cerebrovascular, spine neurosurgeons relatively underperformed in general clinical, anesthesia and critical care, and tumor. The SANS Spine Examination demonstrated knowledge gaps in specific categories for spinal surgeons. The knowledge areas of diminished performance differed between spinal and general neurosurgeons. Identification of specific areas of deficiency could prove useful in the design and implementation of educational programs and maintenance of certification. Copyright © 2013 Elsevier Inc. All rights reserved.

Introduction. Information, knowledge and technology.

PubMed

MacFarlane, Alistair G J

2003-08-15

Technology is the sum of the ways in which social groups manipulate order in the world to achieve their ends. It enables our active engagement with the world. Technology is central to our present well-being and vital for our future survival. As such it needs a coherent world view, a conceptual framework which will enable the fundamental problems that it poses for society to be approached in an illuminating way. Furthermore, such an approach, while remaining convincing, must not be overwhelmed by an ever-increasing welter of specialization and diversity of application. It is the purpose of the set of papers presented here to examine some key aspects of such a conceptual framework; not in the sense of offering a fully worked out philosophy of technology--that would be a huge and complex undertaking--but rather by considering some key topics. Subsidiary aims are to survey important relevant areas, to identify key sources that can provide access points for further study, and to consider some possible future developments. Major, coherent domains of activity are characterized by a few, fundamental, extensively used and essentially unifying concepts. Technology is such a domain, and its fundamental concepts are information, knowledge and agency. The following sections give a synoptic overview of the material presented in this theme issue, and set it within a wider context.

Application of real-time digitization techniques in beam measurement for accelerators

NASA Astrophysics Data System (ADS)

Zhao, Lei; Zhan, Lin-Song; Gao, Xing-Shun; Liu, Shu-Bin; An, Qi

2016-04-01

Beam measurement is very important for accelerators. In this paper, modern digital beam measurement techniques based on IQ (In-phase & Quadrature-phase) analysis are discussed. Based on this method and high-speed high-resolution analog-to-digital conversion, we have completed three beam measurement electronics systems designed for the China Spallation Neutron Source (CSNS), Shanghai Synchrotron Radiation Facility (SSRF), and Accelerator Driven Sub-critical system (ADS). Core techniques of hardware design and real-time system calibration are discussed, and performance test results of these three instruments are also presented. Supported by National Natural Science Foundation of China (11205153, 10875119), Knowledge Innovation Program of the Chinese Academy of Sciences (KJCX2-YW-N27), and the Fundamental Research Funds for the Central Universities (WK2030040029),and the CAS Center for Excellence in Particle Physics (CCEPP).

Polarization-sensitive optical coherence tomography measurements with different phase modulation amplitude when using continuous polarization modulation

NASA Astrophysics Data System (ADS)

Lu, Zenghai; Kasaragod, Deepa K.; Matcher, Stephen J.

2012-01-01

We demonstrate theoretically and experimentally that the phase retardance and relative optic-axis orientation of a sample can be calculated without prior knowledge of the actual value of the phase modulation amplitude when using a polarization-sensitive optical coherence tomography system based on continuous polarization modulation (CPM-PS-OCT). We also demonstrate that the sample Jones matrix can be calculated at any values of the phase modulation amplitude in a reasonable range depending on the system effective signal-to-noise ratio. This has fundamental importance for the development of clinical systems by simplifying the polarization modulator drive instrumentation and eliminating its calibration procedure. This was validated on measurements of a three-quarter waveplate and an equine tendon sample by a fiber-based swept-source CPM-PS-OCT system.

Conceptual Commitments of the LIDA Model of Cognition

NASA Astrophysics Data System (ADS)

Franklin, Stan; Strain, Steve; McCall, Ryan; Baars, Bernard

2013-06-01

Significant debate on fundamental issues remains in the subfields of cognitive science, including perception, memory, attention, action selection, learning, and others. Psychology, neuroscience, and artificial intelligence each contribute alternative and sometimes conflicting perspectives on the supervening problem of artificial general intelligence (AGI). Current efforts toward a broad-based, systems-level model of minds cannot await theoretical convergence in each of the relevant subfields. Such work therefore requires the formulation of tentative hypotheses, based on current knowledge, that serve to connect cognitive functions into a theoretical framework for the study of the mind. We term such hypotheses "conceptual commitments" and describe the hypotheses underlying one such model, the Learning Intelligent Distribution Agent (LIDA) Model. Our intention is to initiate a discussion among AGI researchers about which conceptual commitments are essential, or particularly useful, toward creating AGI agents.

Brackets, epitopes and flash memory cards: a futuristic view of clinical orthodontics.

PubMed

Sims, Milton R

2017-02-01

Orthodontics continues to be a profession anchored in traditional technology using appliances that cause inflammatory periodontal ligament (PDL) responses. Existing concepts of biological tooth movement based largely on histological tissue observations and the application of physical principles require major reassessment. In the next millennium, the genome revolution and knowledge of protein production and control could lead to the genetic correction of dentofacial anomalies and pain-free, biomolecular methods of malocclusion correction and long-term stability. A fundamental change is likely to be the abolition of bracket systems and their replacement with preprogrammed microchips driven by computers, and the control of PD[ blood vessels and cells by pharmacological targeting. Future survival of the profession will depend on a radically different specialist who will be educated with a postgraduate curriculum based on molecular biology and computer engineering.

Situated mathematics teaching within electrical engineering courses

NASA Astrophysics Data System (ADS)

Hennig, Markus; Mertsching, Bärbel; Hilkenmeier, Frederic

2015-11-01

The initial phase of undergraduate engineering degree programmes often comprises courses requiring mathematical expertise which in some cases clearly exceeds school mathematics, but will be imparted only later in mathematics courses. In this article, an approach addressing this challenge by way of example within a fundamentals of electrical engineering course is presented. The concept focuses on gaining specific mathematical knowledge and competencies in the technical context of this course. For this purpose, a complementary blended learning scenario centring around a web-based learning platform and involving an adaptation of the course was developed. The concept particularly considers the heterogeneity of today's student groups and is discussed with regard to related approaches, didactical considerations, and technical implementation. For the interventions, the results of a questionnaire-based evaluation proving students' acceptance and positive influence on examination performance are presented.

Recent Landmark Studies on Head and Neck Cancers: Evidence-Based Fundamentals of Modern Therapeutic Approaches.

PubMed

Aydil, Utku

2015-03-01

Evidence-based medicine, established on prospective studies and related algorithms is living its golden age in recent years. Within the last few decades, medical knowledge has been systematically produced, categorized, and spread in a way never seen before. One of the most important factors in realizing this situation is the expansion of the communication facilities. The area of the management of head and neck cancers was also affected by these advances, and studies with high-level evidence became the mainstay in the determination of the management strategies. However, probably almost all of these studies are about non-surgical modalities, and studies with high-level evidence regarding the surgical treatment of head and neck cancers are scarce. In this paper, important studies on head and neck cancers and their results will be reviewed.

Nuclear instrumentation and measurement: a review based on the ANIMMA conferences

NASA Astrophysics Data System (ADS)

Giot, Michel; Vermeeren, Ludo; Lyoussi, Abdallah; Reynard-Carette, Christelle; Lhuillier, Christian; Mégret, Patrice; Deconinck, Frank; Gonçalves, Bruno Soares

2017-12-01

The ANIMMA conferences offer a unique opportunity to discover research carried out in all fields of nuclear measurements and instrumentation with applications extending from fundamental physics to fission and fusion reactors, medical imaging, environmental protection and homeland security. After four successful editions of the Conference, it was decided to prepare a review based to a large extent but not exclusively on the papers presented during the first four editions of the conference. This review is organized according to the measurement methodologies: neutronic, photonic, thermal, acoustic and optical measurements, as well as medical imaging and specific challenges linked to data acquisition and electronic hardening. The paper describes the main challenges justifying research in these different areas, and summarizes the recent progress reported. It offers researchers and engineers a way to quickly and efficiently access knowledge in highly specialized areas.

Accelerating Translational Research through Open Science: The Neuro Experiment.

PubMed

Gold, E Richard

2016-12-01

Translational research is often afflicted by a fundamental problem: a limited understanding of disease mechanisms prevents effective targeting of new treatments. Seeking to accelerate research advances and reimagine its role in the community, the Montreal Neurological Institute (Neuro) announced in the spring of 2016 that it is launching a five-year experiment during which it will adopt Open Science-open data, open materials, and no patenting-across the institution. The experiment seeks to examine two hypotheses. The first is whether the Neuro's Open Science initiative will attract new private partners. The second hypothesis is that the Neuro's institution-based approach will draw companies to the Montreal region, where the Neuro is based, leading to the creation of a local knowledge hub. This article explores why these hypotheses are likely to be true and describes the Neuro's approach to exploring them.

Fundamental insights into interfacial catalysis.

PubMed

Gong, Jinlong; Bao, Xinhe

2017-04-03

Surface and interfacial catalysis plays a vital role in chemical industries, electrochemistry and photochemical reactions. The challenges of modern chemistry are to optimize the chemical reaction processes and understand the detailed mechanism of chemical reactions. Since the early 1960s, the foundation of surface science systems has allowed the study of surface and interfacial phenomena on atomic/molecular level, and thus brought a number of significant developments to fundamental and technological processes, such as catalysis, material science and biochemistry, just to name a few. This themed issue describes the recent advances and developments in the fundamental understanding of surface and interfacial catalysis, encompassing areas of knowledge from metal to metal oxide, carbide, graphene, hexagonal boron nitride, and transition metal dichalcogenides under ultrahigh vacuum conditions, as well as under realistic reaction conditions.

Comustion of HAN-Based Monopropellant Droplets in Reduced Gravity

NASA Technical Reports Server (NTRS)

Shaw, B. D.

2001-01-01

Hydroxylammonium nitrate (HAN) is a major constituent in a class of liquid monopropellants that have many attractive characteristics and which display phenomena that differ significantly from other liquid monopropellants. They are composed primarily of HAN, H2O and a fuel species, often triethanolammonium nitrate (TEAN). HAN-based propellants have attracted attention as liquid gun propellants, and are attractive for NASA spacecraft propulsion applications. A representative propellant is XM46. This mixture is 60.8% HAN, 19.2% TEAN and 20% H2O by weight. Other HAN-based propellant mixtures are also of interest. For example, methanol and glycine have been investigated as potential fuel species for HAN-based monopropellants for thruster applications. In the present research, experimental and theoretical studies are performed on combustion of HAN-based monopropellant droplets. The fuel species considered are TEAN, methanol and glycine. Droplets initially in the mm size range are studied at pressures up to 30 atm. These pressures are applicable to spacecraft thruster applications. The droplets are placed in environments with various amounts of Ar, N2, O2, NO2 and N2O. Reduced gravity is employed to enable observations of burning rates and flame structures to be made without the complicating effects of buoyant and forced convection. Normal gravity experiments are also performed in this research program. The experiment goals are to provide accurate fundamental data on deflagration rates, gasphase temperature profiles, transient gas-phase flame behaviors, the onset of bubbling in droplets at lower pressures, and the low-pressure deflagration limit. Theoretical studies are performed to provide rational models of deflagration mechanisms of HAN-based liquid propellants. Besides advancing fundamental knowledge, this research should aid in applications (e.g., spacecraft thrusters and liquid propellant guns) of this unique class of monopropellants.

So, why do we still have journals?

NASA Astrophysics Data System (ADS)

Hut, R.

2014-12-01

The academic article is a relic from a bygone age. Form and style have not changed much since the days of Einstein and Wegener, nor have the institutions that publish our academic knowledge. When I google-scholar an article, I do not care if it was published in nature, PNAS, or the annals of the cambodian society of herbologists. I care about the scientific knowledge contained in the article, that I would like to use in my own work. So: why do we have journals again? The journal-based system of scientific publication is cracking under its own weight. The publish or perish culture leads to an ever increasing number of articles, each containing less actual science, because spreading over multiple papers helps your career. Journal editors complain that the average number of scientists that they approach for reviewing has gone up because there is no incentive in being a reviewer, only in being reviewed. And finally: much research money is wasted because reviewers point out fundamental flaws in experiment setups after the fact. In this talk, I will present a new way of publishing scientific knowledge. A departure of the classic systems, my way aims to keep the thoroughness of the peer reviewed system, increase the effective use of funding and make more scientific knowledge publically available. Also, it abolishes the need for journals.

An Overview of the Launch Vehicle Blast Environments Development Efforts

NASA Technical Reports Server (NTRS)

Richardson, Erin; Bangham, Mike; Blackwood, James; Skinner, Troy; Hays, Michael; Jackson, Austin; Richman, Ben

2014-01-01

NASA has been funding an ongoing development program to characterize the explosive environments produced during a catastrophic launch vehicle accident. These studies and small-scale tests are focused on the near field environments that threaten the crew. The results indicate that these environments are unlikely to result in immediate destruction of the crew modules. The effort began as an independent assessment by NASA safety organizations, followed by the Ares program and NASA Engineering and Safety Center and now as a Space Launch Systems (SLS) focused effort. The development effort is using the test and accident data available from public or NASA sources as well as focused scaled tests that are examining the fundamental aspects of uncontained explosions of Hydrogen and air and Hydrogen and Oxygen. The primary risk to the crew appears to be the high-energy fragments and these are being characterized for the SLS. The development efforts will characterize the thermal environment of the explosions as well to ensure that the risk is well understood and to document the overall energy balance of an explosion. The effort is multi-path in that analytical, computational and focused testing is being used to develop the knowledge to understand potential SLS explosions. This is an ongoing program with plans that expand the development from fundamental testing at small-scale levels to large-scale tests that can be used to validate models for commercial programs. The ultimate goal is to develop a knowledge base that can be used by vehicle designers to maximize crew survival in an explosion.

Youth Sport Readiness: A Predictive Model for Success.

ERIC Educational Resources Information Center

Aicinena, Steven

1992-01-01

A model for predicting organized youth sport participation readiness has four predictive components: sport-related fundamental motor skill development; sport-specific knowledge; motivation; and socialization. Physical maturation is also important. The model emphasizes the importance of preparing children for successful participation through…

FUNDAMENTALS OF TELEVISION SYSTEMS.

ERIC Educational Resources Information Center

KESSLER, WILLIAM J.

DESIGNED FOR A READER WITHOUT SPECIAL TECHNICAL KNOWLEDGE, THIS ILLUSTRATED RESOURCE PAPER EXPLAINS THE COMPONENTS OF A TELEVISION SYSTEM AND RELATES THEM TO THE COMPLETE SYSTEM. SUBJECTS DISCUSSED ARE THE FOLLOWING--STUDIO ORGANIZATION AND COMPATIBLE COLOR TELEVISION PRINCIPLES, WIRED AND RADIO TRANSMISSION SYSTEMS, DIRECT VIEW AND PROJECTION…

The Public Life of Information

ERIC Educational Resources Information Center

Rowe, Josh

2011-01-01

The mid-twentieth century marked a shift in Americans' fundamental orientation toward information. Rather than news or knowledge, information became a disembodied quantum--strings of ones and zeros processed, increasingly, by complex machines. This dissertation examines how Americans became acquainted with "information", as newly conceived by…

A Course on Surface Phenomena.

ERIC Educational Resources Information Center

Woods, Donald R.

1983-01-01

Describes a graduate or senior elective course combining fundamentals of surface phenomena with practical problem-solving structured around a series of case problems. Discusses topics covered and their development through acquiring new knowledge applied to the case problem, practical calculations of solutions, and applications to additional…

Reflections on Assessment

ERIC Educational Resources Information Center

DiRanna, Kathy; Osmundson, Ellen; Topps, Jo; Gearhart, Maryl

2008-01-01

In this article, the authors describe an assessment-centered teaching (ACT) framework they developed to communicate the integration of assessment and instruction. The framework is a visual representation of the relationships among the fundamental elements of assessment knowledge: the characteristics of quality goals for student learning and…

Fundamental concepts, current regulatory design and interpretation

EPA Science Inventory

Developmental toxicology became a formalized field about 50 years ago. Over this time, it has evolved from a largely observational science to one that is highly mechanistic in nature. Our increasing knowledge of mechanism of action, coupled with techniques that facilitate the gen...

Teaching for the Transition: the Canadian PGY-1 Neurosurgery 'Rookie Camp'.

PubMed

Haji, Faizal A; Clarke, David B; Matte, Marie C; Brandman, David M; Brien, Susan; de Ribaupierre, Sandrine; O'Kelly, Cian; Christie, Sean; McDonald, Patrick J; Kulkarni, Abhaya V; Walling, Simon; MacLeod, Anna

2015-01-01

Transitioning from medical school to residency is difficult and stressful, necessitating innovation in easing this transition. In response, a Canadian neurosurgical Rookie Camp was designed and implemented to foster acquisition of technical, cognitive and behavioral skills among incoming Canadian post graduate year one (PGY-1) neurosurgery residents. The inaugural Rookie Camp was held in July 2012 in Halifax. The curriculum was developed based on a national needs-assessment and consisted of a pre-course manual, 7 case-based stations, 4 procedural skills stations and 2 group discussions. The content was clinically focused, used a variety of teaching methods, and addressed multiple CanMEDS competencies. Evaluation included participant and faculty surveys and a pre-course, post-course, and 3-month retention knowledge test. 17 of 23 PGY-1 Canadian neurosurgical residents participated in the Camp. All agreed the course content was relevant for PGY-1 training and the experience prepared them for residency. All participants would recommend the course to future neurosurgical residents. A statistically significant improvement was observed in knowledge related to course content (F(2,32) = 7.572, p<0.002). There were no significant differences between post-test and retention-test scores at three months. The inaugural Canadian Neurosurgery Rookie Camp for PGY-1 residents was successfully delivered, with engagement from participants, training programs, the Canadian Neurosurgical Society, and the Royal College. In addition to providing fundamental knowledge, which was shown to be retained, the course eased junior residents' transition to residency by fostering camaraderie and socialization within the specialty.

Plant Distribution Data Show Broader Climatic Limits than Expert-Based Climatic Tolerance Estimates

PubMed Central

Curtis, Caroline A.; Bradley, Bethany A.

2016-01-01

Background Although increasingly sophisticated environmental measures are being applied to species distributions models, the focus remains on using climatic data to provide estimates of habitat suitability. Climatic tolerance estimates based on expert knowledge are available for a wide range of plants via the USDA PLANTS database. We aim to test how climatic tolerance inferred from plant distribution records relates to tolerance estimated by experts. Further, we use this information to identify circumstances when species distributions are more likely to approximate climatic tolerance. Methods We compiled expert knowledge estimates of minimum and maximum precipitation and minimum temperature tolerance for over 1800 conservation plant species from the ‘plant characteristics’ information in the USDA PLANTS database. We derived climatic tolerance from distribution data downloaded from the Global Biodiversity and Information Facility (GBIF) and corresponding climate from WorldClim. We compared expert-derived climatic tolerance to empirical estimates to find the difference between their inferred climate niches (ΔCN), and tested whether ΔCN was influenced by growth form or range size. Results Climate niches calculated from distribution data were significantly broader than expert-based tolerance estimates (Mann-Whitney p values << 0.001). The average plant could tolerate 24 mm lower minimum precipitation, 14 mm higher maximum precipitation, and 7° C lower minimum temperatures based on distribution data relative to expert-based tolerance estimates. Species with larger ranges had greater ΔCN for minimum precipitation and minimum temperature. For maximum precipitation and minimum temperature, forbs and grasses tended to have larger ΔCN while grasses and trees had larger ΔCN for minimum precipitation. Conclusion Our results show that distribution data are consistently broader than USDA PLANTS experts’ knowledge and likely provide more robust estimates of climatic tolerance, especially for widespread forbs and grasses. These findings suggest that widely available expert-based climatic tolerance estimates underrepresent species’ fundamental niche and likely fail to capture the realized niche. PMID:27870859

Using concept mapping in the knowledge-to-action process to compare stakeholder opinions on barriers to use of cancer screening among South Asians.

PubMed

Lobb, Rebecca; Pinto, Andrew D; Lofters, Aisha

2013-03-23

Using the knowledge-to-action (KTA) process, this study examined barriers to use of evidence-based interventions to improve early detection of cancer among South Asians from the perspective of multiple stakeholders. In 2011, we used concept mapping with South Asian residents, and representatives from health service and community service organizations in the region of Peel Ontario. As part of concept mapping procedures, brainstorming sessions were conducted with stakeholders (n = 53) to identify barriers to cancer screening among South Asians. Participants (n = 46) sorted barriers into groups, and rated barriers from lowest (1) to highest (6) in terms of importance for use of mammograms, Pap tests and fecal occult blood tests, and how feasible it would be to address them. Multi-dimensional scaling, cluster analysis, and descriptive statistics were used to analyze the data. A total of 45 unique barriers to use of mammograms, Pap tests, and fecal occult blood tests among South Asians were classified into seven clusters using concept mapping procedures: patient's beliefs, fears, lack of social support; health system; limited knowledge among residents; limited knowledge among physicians; health education programs; ethno-cultural discordance with the health system; and cost. Overall, the top three ranked clusters of barriers were 'limited knowledge among residents,' 'ethno-cultural discordance,' and 'health education programs' across surveys. Only residents ranked 'cost' second in importance for fecal occult blood testing, and stakeholders from health service organizations ranked 'limited knowledge among physicians' third for the feasibility survey. Stakeholders from health services organizations ranked 'limited knowledge among physicians' fourth for all other surveys, but this cluster consistently ranked lowest among residents. The limited reach of cancer control programs to racial and ethnic minority groups is a critical implementation issue that requires attention. Opinions of community service and health service organizations on why this deficit in implementation occurs are fundamental to understanding the solutions because these are the settings in which evidence-based interventions are implemented. Using concept mapping within a KTA process can facilitate the engagement of multiple stakeholders in the utilization of study results and in identifying next steps for action.

Evidence-based practice in chiropractic practice: A survey of chiropractors' knowledge, skills, use of research literature and barriers to the use of research evidence.

PubMed

Walker, B F; Stomski, N J; Hebert, J J; French, S D

2014-04-01

Scant research has been undertaken regarding chiropractors' skills and knowledge associated with evidence-based practice (EBP), and their perceived barriers to EBP. These issues appear to have been examined in only one small qualitative study and one small study of chiropractors holding orthopaedic diplomas. The lack of research in this area suggests that additional studies are warranted to develop a better understanding of factors that affect chiropractors' use of research evidence in clinical practice. We used a modified online questionnaire that captured information regarding EBP skills and knowledge, and barriers to EBP. Its adaption was informed by the use of a content validity panel. The questionnaire was disseminated through email by Australian chiropractic professional organisations and the Chiropractic Board of Australia. Logistic regression analyses were conducted to examine univariate associations between responses to items measuring knowledge and skills with items measuring: age; years since registration; reading research literature; and use of research literature in clinical decision-making. 584 respondents returned questionnaires. About half of the respondents stated they had learned the foundations of EBP (56.6%) during their undergraduate training. Slightly more than two thirds of the respondents were confident in their ability to critically review literature (69.5%) and find relevant research to answer clinical questions (72.6%). The most common factors involved with reading more research, and increased use of research literature in clinical decision-making, were confidence in critical appraisal skills and confidence in finding relevant research literature. Conclusion Educational interventions should be implemented to enhance Australian chiropractors' fundamental EBP skills. Copyright © 2014 Elsevier Ltd. All rights reserved.

Evidence-based medicine knowledge, attitudes, and practices among doctors in Sri Lanka.

PubMed

Abeysena, Chrishantha; Jayawardana, Pushpa; Wickremasinghe, Rajitha; Wickramasinghe, Uthpala

2010-05-01

To assess knowledge, attitudes, and practices on evidence-based medicine (EBM) among doctors in selected hospitals in Sri Lanka. A cross-sectional descriptive study was conducted among 315 doctors in five government hospitals in Sri Lanka between December 2007 and January 2008. A pre-tested self-administered questionnaire was used to gather information on knowledge, attitudes, and practices. Of the 407 invited, 315 doctors participated, among whom, 87% (271) had heard the term EBM, 30% (n= 94) were aware of the Cochrane Library, and 8.5% (n= 27) were current users of it. Forty-seven per cent (n= 148) claimed to understand the terms systematic review and 37% (n= 115) meta-analysis. Twenty-four per cent (n= 77) had been exposed to some form of EBM training. All three components of EBM were known by 18% (n= 56) of participants. Attitudes toward EBM were positive among 76% (n= 239), 80% (n= 251) believed the practice of EBM would lead to improved patient care, and 77% (n= 243) considered EBM to be fundamental to professional practice. Just 3% (n= 13) considered it unimportant. EBM was used in clinical practice by 54% (n= 169) of participants. Thirty-six per cent (n= 114) referred to EBM sources when relevant. Available clinical guidelines were referred to by 56% (n= 176), and 34% (n= 107) thought that available guidelines provide sufficient support for the practice of EBM. The main barriers to practicing EBM were insufficient resources, overwork, lack of exposure to EBM, and lack of time and lack of endorsement of the need to practice EBM. Knowledge and practices of EBM among Sri Lanka doctors were poor. However, attitudes toward EBM were relatively good. © 2010 Blackwell Publishing Asia Pty Ltd and Chinese Cochrane Center, West China Hospital of Sichuan University.

Contemporary HIV/AIDS research: Insights from knowledge management theory

PubMed Central

Callaghan, Chris William

2017-01-01

Abstract Knowledge management as a field is concerned with the management of knowledge, including the management of knowledge in research processes. Knowledge management theory has the potential to support research into problems such as HIV, antibiotic resistance and others, particularly in terms of aspects of scientific research related to the contribution of social science. To date, however, these challenges remain with us, and theoretical contributions that can complement natural science efforts to eradicate these problems are needed. This paper seeks to offer a theoretical contribution grounded in Kuhn’s paradigm theory of innovation, and in the argument by Lakatos that scientific research can be fundamentally non-innovative, which suggests that social science aspects of knowledge creation may hold the key to more effective biomedical innovation. Given the consequences of ongoing and emerging global crises, and the failure of knowledge systems of scientific research to solve such problems outright, this paper provides a review of theory and literature arguing for a new paradigm in scientific research, based on the development of global systems to maximise research collaborations. A global systems approach effectively includes social science theory development as an important complement to the natural sciences research process. Arguably, information technology and social media technology have developed to the point at which solutions to knowledge aggregation challenges can enable solutions to knowledge problems on a scale hitherto unimaginable. Expert and non-expert crowdsourced inputs can enable problem-solving through exponentially increasing problem-solving inputs, using the ‘crowd,’ thereby increasing collaborations dramatically. It is argued that these developments herald a new era of participatory research, or a democratisation of research, which offers new hope for solving global social problems. This paper seeks to contribute to this end, and to the recognition of the important role of social theory in the scientific research process. PMID:28922967

Biogeochemical cycles and biodiversity as key drivers of ecosystem services provided by soils

NASA Astrophysics Data System (ADS)

Smith, P.; Cotrufo, M. F.; Rumpel, C.; Paustian, K.; Kuikman, P. J.; Elliott, J. A.; McDowell, R.; Griffiths, R. I.; Asakawa, S.; Bustamante, M.; House, J. I.; Sobocká, J.; Harper, R.; Pan, G.; West, P. C.; Gerber, J. S.; Clark, J. M.; Adhya, T.; Scholes, R. J.; Scholes, M. C.

2015-11-01

Soils play a pivotal role in major global biogeochemical cycles (carbon, nutrient, and water), while hosting the largest diversity of organisms on land. Because of this, soils deliver fundamental ecosystem services, and management to change a soil process in support of one ecosystem service can either provide co-benefits to other services or result in trade-offs. In this critical review, we report the state-of-the-art understanding concerning the biogeochemical cycles and biodiversity in soil, and relate these to the provisioning, regulating, supporting, and cultural ecosystem services which they underpin. We then outline key knowledge gaps and research challenges, before providing recommendations for management activities to support the continued delivery of ecosystem services from soils. We conclude that, although soils are complex, there are still knowledge gaps, and fundamental research is still needed to better understand the relationships between different facets of soils and the array of ecosystem services they underpin, enough is known to implement best practices now. There is a tendency among soil scientists to dwell on the complexity and knowledge gaps rather than to focus on what we do know and how this knowledge can be put to use to improve the delivery of ecosystem services. A significant challenge is to find effective ways to share knowledge with soil managers and policy makers so that best management can be implemented. A key element of this knowledge exchange must be to raise awareness of the ecosystems services underpinned by soils and thus the natural capital they provide. We know enough to start moving in the right direction while we conduct research to fill in our knowledge gaps. The lasting legacy of the International Year of Soils in 2015 should be for soil scientists to work together with policy makers and land managers to put soils at the centre of environmental policy making and land management decisions.

When Is a Program Intelligent?

ERIC Educational Resources Information Center

Whaland, Norman

1981-01-01

The current status of creating artificial intelligence (AI) in computers is viewed in terms of what has been accomplished, what the current limitations are, and how vague the concept of intelligent behavior is in today's world. Progress is expected to accelerate once sufficient fundamental knowledge is available. (MP)

WWW: The Scientific Method

ERIC Educational Resources Information Center

Blystone, Robert V.; Blodgett, Kevin

2006-01-01

The scientific method is the principal methodology by which biological knowledge is gained and disseminated. As fundamental as the scientific method may be, its historical development is poorly understood, its definition is variable, and its deployment is uneven. Scientific progress may occur without the strictures imposed by the formal…

77 FR 13297 - Applications for New Awards; Education Research and Special Education Research Grant Programs

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-06

... national leadership in expanding fundamental knowledge and understanding of developmental and school..., Management, and Leadership Mathematics and Science Education Postsecondary and Adult Education Reading and...: Policies, Organization, Management, and Leadership. [ssquf] Early Learning Programs and Policies. [ssquf...

Word Recognition in Auditory Cortex

ERIC Educational Resources Information Center

DeWitt, Iain D. J.

2013-01-01

Although spoken word recognition is more fundamental to human communication than text recognition, knowledge of word-processing in auditory cortex is comparatively impoverished. This dissertation synthesizes current models of auditory cortex, models of cortical pattern recognition, models of single-word reading, results in phonetics and results in…

Launching an Interdisciplinary "International Summer School on Ageing" (ISSA): Aims, Methodology, and Outcomes

ERIC Educational Resources Information Center

Barbabella, F.; Chiatti, C.; Di Rosa, M.; Lamura, G.; Martin-Matthews, A.; Papa, R.; Svensson, T.

2016-01-01

Despite the increasing availability of gerontological training programs, knowledge of their contents, characteristics, methods, and outcomes remains limited. However, the transition from multidisciplinarity to interdisciplinary orientations is now fundamental to such training, providing participants from diverse academic orientations and…

Teacher Knowledge for Active-Learning Instruction: Expert-Novice Comparison Reveals Differences

ERIC Educational Resources Information Center

Auerbach, A. J.; Higgins, M.; Brickman, P.; Andrews, T. C.

2018-01-01

Active-learning strategies "can" improve science, technology, engineering, and mathematics (STEM) undergraduates' abilities to learn fundamental concepts and skills. However, the results instructors achieve vary substantially. One explanation for this is that instructors commonly implement active learning differently than intended. An…

Tracking a Global Academic Revolution

ERIC Educational Resources Information Center

Altbach, Philip G.; Reisberg, Liz; Rumbley, Laura E.

2010-01-01

A global revolution has been taking place in higher education during the past half-century. In the educators' view, four fundamental and interrelated forces have impelled the current academic revolution: the "massification" of higher education, globalization, the advent of the knowledge society and the importance of research universities…

7 CFR 3022.1 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-01-01

... toward fuller knowledge or understanding of the fundamental aspects of phenomena and of observable facts...). The Office of Inspector General of the United States Department of Agriculture. Office of Science and Technology Policy (OSTP). The Office of Science and Technology Policy of the Executive Office of the...

7 CFR 3022.1 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-01-01

... toward fuller knowledge or understanding of the fundamental aspects of phenomena and of observable facts...). The Office of Inspector General of the United States Department of Agriculture. Office of Science and Technology Policy (OSTP). The Office of Science and Technology Policy of the Executive Office of the...

7 CFR 3022.1 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-01-01

... toward fuller knowledge or understanding of the fundamental aspects of phenomena and of observable facts...). The Office of Inspector General of the United States Department of Agriculture. Office of Science and Technology Policy (OSTP). The Office of Science and Technology Policy of the Executive Office of the...

7 CFR 3022.1 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-01-01

... toward fuller knowledge or understanding of the fundamental aspects of phenomena and of observable facts...). The Office of Inspector General of the United States Department of Agriculture. Office of Science and Technology Policy (OSTP). The Office of Science and Technology Policy of the Executive Office of the...

WASTE-TO-RESOURCE: NOVEL MEMBRANE SYSTEMS FOR SAFE AND SUSTAINABLE BRINE MANAGEMENT

EPA Science Inventory

Decentralized waste-to-reuse systems will be optimized to maximize resource and energy recovery and minimize chemicals and energy use. This research will enhance fundamental knowledge on simultaneous heat and mass transport through membranes, lower process costs, and furthe...

76 FR 77854 - Notice of Intent To Seek Approval To Establish an Information Collection

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-14

... Reporting Requirements for the Engineering Research Centers (ERCs). OMB Number: 3145-NEW. Expiration Date of.... Abstract Proposed Project The Engineering Research Centers (ERC) program supports an integrated, interdisciplinary research environment to advance fundamental engineering knowledge and engineered systems; educate...

Teacher Professionalism: The Wrong Conversation.

ERIC Educational Resources Information Center

Coulter, David; Orme, Liz

2000-01-01

Defining teachers as professionals in the same way that doctors or engineers are professionals is reductionist because such definition generally distorts the moral dimensions of teaching by using the wrong language (clients, customers), focusing on limited forms of knowledge, and ignoring the fundamental democratic character of education.…

The Modern View of Nature's Building Blocks.

ERIC Educational Resources Information Center

Akyeampong, D. A.

1985-01-01

Explains current knowledge about the makeup of matter at the microscopic (and even more infinitesimal) levels, accentuating the role of accelerators in the process and considering whether more fundamental particles may exist. Classification of subatomic particles, hadrons, quarks, and gluons are among the areas examined. (JN)

Engineering Veterinary Education.

ERIC Educational Resources Information Center

Eyre, Peter

2002-01-01

Calls for a new model for veterinary education, drawn from engineering education, which imparts a strong core of fundamental biomedical knowledge and multi-species clinical experience to all students than allows a genuine opportunity for differentiation into strongly focused subject areas that provide in-depth education and training appropriate to…

An Online Graduate Requirements Engineering Course

ERIC Educational Resources Information Center

Kilicay-Ergin, N.; Laplante, P. A.

2013-01-01

Requirements engineering is one of the fundamental knowledge areas in software and systems engineering graduate curricula. Recent changes in educational delivery and student demographics have created new challenges for requirements engineering education. In particular, there is an increasing demand for online education for working professionals.…

Active Learning: The Way Children Construct Knowledge.

ERIC Educational Resources Information Center

Hohmann, Mary; Weikart, David P.

2002-01-01

The High/Scope approach to early childhood education promotes the belief that active learning is fundamental to the development of human potential and occurs most effectively in settings that provide developmentally appropriate learning opportunities. Describes five ingredients of active learning (materials, manipulation, choice, language from…

The Practice and Products of Communication Inquiry and Education.

ERIC Educational Resources Information Center

Warren, Clay

1982-01-01

The ability to communicate effectively is fundamental to communication education. For internal validity, communication educators need to concentrate on knowledge-building (competence) and skills training (performance). For external validity, the speech communication discipline must establish a common understanding of its work and send clear…

Measuring Environmental Health Perception among College Students

ERIC Educational Resources Information Center

Ratnapradipa, Dhitinut; Brown, Stephen L.; Middleton, Wendi K.; Wodika, Alicia B.

2011-01-01

One's knowledge, perception, and attitude are fundamental in determining how one behaves regarding environmental hazards. While science has made great strides in promoting environmental health, threats still exist, largely due to individual actions in response to potential health hazards. Undergraduate students (n = 395) enrolled in an…

Chemical Equilibrium in Supramolecular Systems as Studied by NMR Spectrometry

ERIC Educational Resources Information Center

Gonzalez-Gaitano, Gustavo; Tardajos, Gloria

2004-01-01

Undergraduate students are required to study the chemical balance in supramolecular assemblies constituting two or more interacting species, by using proton NMR spectrometry. A good knowledge of physical chemistry, fundamentals of chemical balance, and NMR are pre-requisites for conducting this study.

Cognitive Learning Styles of EFL Students

ERIC Educational Resources Information Center

Srichanyachon, Napaporn

2011-01-01

This study aimed to study cognitive learning styles of EFL students, compare language learning styles among students categorized by their background, and investigate the relationship between English background knowledge and language learning styles. The samples were 210 undergraduate students enrolled in Fundamental English course at Bangkok…

Knowledge and Human Values: A Genealogy of Nihilism.

ERIC Educational Resources Information Center

Dreyfus, Hubert L.

1981-01-01

Nihilism is the fundamental movement in the history of the West. Materialism is a symptom of nihilism. Materialism is the view that all meaning has gone from the cosmos, nature, and culture. Values are objective, explicit options which imply the existence of choice. (JN)

Passive and iontophoretic transport through the skin polar pathway.

PubMed

Li, S K; Peck, K D

2013-01-01

The purpose of the present article is to briefly recount the contributions of Prof. William I. Higuchi to the area of skin transport. These contributions include developing fundamental knowledge of the barrier properties of the stratum corneum, mechanisms of skin transport, concentration gradient across skin in topical drug applications that target the viable epidermal layer, and permeation enhancement by chemical and electrical means. The complex and changeable nature of the skin barrier makes it difficult to assess and characterize the critical parameters that influence skin permeation. The systematic and mechanistic approaches taken by Dr. Higuchi in studying these parameters provided fundamental knowledge in this area and had a measured and lasting influence upon this field of study. This article specifically reviews the validation and characterization of the polar permeation pathway, the mechanistic model of skin transport, the influence of the dermis on the target skin concentration concept, and iontophoretic transport across the polar pathway of skin including the effects of electroosmosis and electropermeabilization. © 2013 S. Karger AG, Basel.

Presynaptic mechanisms of lead neurotoxicity: effects on vesicular release, vesicle clustering and mitochondria number.

PubMed

Zhang, Xiao-Lei; Guariglia, Sara R; McGlothan, Jennifer L; Stansfield, Kirstie H; Stanton, Patric K; Guilarte, Tomás R

2015-01-01

Childhood lead (Pb2+) intoxication is a global public health problem and accounts for 0.6% of the global burden of disease associated with intellectual disabilities. Despite the recognition that childhood Pb2+ intoxication contributes significantly to intellectual disabilities, there is a fundamental lack of knowledge on presynaptic mechanisms by which Pb2+ disrupts synaptic function. In this study, using a well-characterized rodent model of developmental Pb2+ neurotoxicity, we show that Pb2+ exposure markedly inhibits presynaptic vesicular release in hippocampal Schaffer collateral-CA1 synapses in young adult rats. This effect was associated with ultrastructural changes which revealed a reduction in vesicle number in the readily releasable/docked vesicle pool, disperse vesicle clusters in the resting pool, and a reduced number of presynaptic terminals with multiple mitochondria with no change in presynaptic calcium influx. These studies provide fundamental knowledge on mechanisms by which Pb2+ produces profound inhibition of presynaptic vesicular release that contribute to deficits in synaptic plasticity and intellectual development.

On Parallel Push-Relabel based Algorithms for Bipartite Maximum Matching

DOE Office of Scientific and Technical Information (OSTI.GOV)

Langguth, Johannes; Azad, Md Ariful; Halappanavar, Mahantesh

2014-07-01

We study multithreaded push-relabel based algorithms for computing maximum cardinality matching in bipartite graphs. Matching is a fundamental combinatorial (graph) problem with applications in a wide variety of problems in science and engineering. We are motivated by its use in the context of sparse linear solvers for computing maximum transversal of a matrix. We implement and test our algorithms on several multi-socket multicore systems and compare their performance to state-of-the-art augmenting path-based serial and parallel algorithms using a testset comprised of a wide range of real-world instances. Building on several heuristics for enhancing performance, we demonstrate good scaling for themore » parallel push-relabel algorithm. We show that it is comparable to the best augmenting path-based algorithms for bipartite matching. To the best of our knowledge, this is the first extensive study of multithreaded push-relabel based algorithms. In addition to a direct impact on the applications using matching, the proposed algorithmic techniques can be extended to preflow-push based algorithms for computing maximum flow in graphs.« less

Vibration analysis of partially cracked plate submerged in fluid

NASA Astrophysics Data System (ADS)

Soni, Shashank; Jain, N. K.; Joshi, P. V.

2018-01-01

The present work proposes an analytical model for vibration analysis of partially cracked rectangular plates coupled with fluid medium. The governing equation of motion for the isotropic plate based on the classical plate theory is modified to accommodate a part through continuous line crack according to simplified line spring model. The influence of surrounding fluid medium is incorporated in the governing equation in the form of inertia effects based on velocity potential function and Bernoulli's equations. Both partially and totally submerged plate configurations are considered. The governing equation also considers the in-plane stretching due to lateral deflection in the form of in-plane forces which introduces geometric non-linearity into the system. The fundamental frequencies are evaluated by expressing the lateral deflection in terms of modal functions. The assessment of the present results is carried out for intact submerged plate as to the best of the author's knowledge the literature lacks in analytical results for submerged cracked plates. New results for fundamental frequencies are presented as affected by crack length, fluid level, fluid density and immersed depth of plate. By employing the method of multiple scales, the frequency response and peak amplitude of the cracked structure is analyzed. The non-linear frequency response curves show the phenomenon of bending hardening or softening and the effect of fluid dynamic pressure on the response of the cracked plate.

1.5  kW ytterbium-doped single-transverse-mode, linearly polarized monolithic fiber master oscillator power amplifier.

PubMed

Huang, Long; Ma, Pengfei; Tao, Rumao; Shi, Chen; Wang, Xiaolin; Zhou, Pu

2015-04-01

A linearly polarized monolithic fiber laser based on a master oscillator power amplifier structure with a master oscillator and a one-stage power amplifier is reported. We design a homemade oscillator based on the theory that, in the coiled gain fiber, the higher modes and the polarized mode of the fundamental mode along the fast axis are suppressed effectively because of their obviously higher bend loss than that of the polarized mode of the fundamental mode along the slow axis. The oscillator operates at 1080 nm, launching a 30 W seed laser with a high polarization extinction ratio of 19 dB into the power amplifier via a mode field adapter. The power amplifier utilizes Yb-doped polarization-maintaining fiber of 20/400  μm, which produces nearly diffraction-limited output power of about 1.5 kW with an optical-optical efficiency of 81.5% and a polarization extinction ratio of 13.8 dB. Both the M(x)² factor and the M(y)² factor of the collimated beam are measured to be about 1.2. The spectral width of the output power is broadened approximately linearly, and the full width at half maximum of the spectrum at the maximum output power is about 5.8 nm. It is known as the highest linearly polarized output power to the best of our knowledge.

Fundamental Properties of the SHIELD Galaxies

NASA Astrophysics Data System (ADS)

Cannon, John; Adams, Betsey; Giovanelli, Riccardo; Haynes, Martha; Jones, Michael; McQuinn, Kristen; Rhode, Katherine; Salzer, John; Skillman, Evan

2018-05-01

The ALFALFA survey has significantly advanced our knowledge of the HI mass function (HIMF), particularly at the low mass end. From the ALFALFA survey, we have constructed a sample of all of the galaxies with HI masses less than 20 million solar masses. Observations of this 82 galaxy sample allow, for the first time, a characterization of the lowest HI mass galaxies at redshift zero. Specifically, this sample can be used to determine the low HI-mass ends of various fundamental scaling relations, including the critical baryonic Tully Fisher relation (BTFR) and the mass-metallicity (M-Z) relation. The M-Z relation and the BTFR are cosmologically important, but current samples leave the low-mass parameter spaces severely underpopulated. A full understanding of these relationships depends critically on accurate stellar masses of this complete sample of uniformly-selected galaxies. Here, we request imaging of the 70 galaxies in our sample that have not been observed with Spitzer. The proposed imaging will allow us to measure stellar masses and inclinations of the sample galaxies using a uniform observational approach. Comparison with (existing and in progress) interferometric HI imaging and with ground-based optical imaging and spectroscopy will enable a robust mass decomposition in each galaxy and accurate placements on the aforementioned scaling relationships. The observations proposed here will allow us to populate the mass continuum between mini-halos and bona fide dwarf galaxies, and to address a range of fundamental questions in galaxy formation and near-field cosmology.

An RR Lyrae family portrait: 33 stars observed in Pisces with K2-E2

NASA Astrophysics Data System (ADS)

Molnár, L.; Szabó, R.; Moskalik, P. A.; Nemec, J. M.; Guggenberger, E.; Smolec, R.; Poleski, R.; Plachy, E.; Kolenberg, K.; Kolláth, Z.

2015-10-01

A detailed analysis is presented of 33 RR Lyrae stars in Pisces observed with the Kepler space telescope over the 8.9-d long K2 Two-Wheel Concept Engineering Test. The sample includes not only fundamental-mode and first-overtone (RRab and RRc) stars but the first two double-mode (RRd) stars that Kepler detected and the only modulated first-overtone star ever observed from space so far. The precision of the extracted K2 light curves made it possible to detect low-amplitude additional modes in all subtypes. All RRd and non-modulated RRc stars show the additional mode at PX/P1 ˜ 0.61 that was detected in previous space-based photometric measurements. A periodicity longer than the fundamental mode was tentatively identified in one RRab star that might belong to a gravity mode. We determined the photometric [Fe/H] values for all fundamental-mode stars and provide the preliminary results of our efforts to fit the double-mode stars with non-linear hydrodynamic pulsation models. The results from this short test run indicate that the K2 mission will be, and has started to be, an ideal tool to expand our knowledge about RR Lyrae stars. As a by-product of the target search and analysis, we identified 165 bona fide double-mode RR Lyrae stars from the Catalina Sky Survey observations throughout the sky, 130 of which are new discoveries.

Association between caregivers' knowledge and care seeking behaviour for children with symptoms of pneumonia in six sub-Saharan African Countries.

PubMed

Noordam, Aaltje Camielle; Sharkey, Alyssa B; Hinssen, Paddy; Dinant, GeertJan; Cals, Jochen W L

2017-02-02

Pneumonia is the main cause of child mortality world-wide and most of these deaths occur in sub-Saharan Africa (SSA). Treatment with effective antibiotics is crucial to prevent these deaths; nevertheless only 2 out of 5 children with symptoms of pneumonia are taken to an appropriate care provider in SSA. While various factors associated with care seeking have been identified, the relationship between caregivers' knowledge of pneumonia symptoms and actual care seeking for their child with symptoms of pneumonia is not well researched. Based on data from Multiple Indicator Cluster Surveys, we assessed the association between caregivers' knowledge of symptoms related to pneumonia - namely fast or difficulty breathing - and care seeking behaviour for these symptoms. We analysed data of 4,163 children with symptoms of pneumonia and their caregivers. A Chi-square tests and multivariable logistic regression was performed to assess the association between care seeking and knowledge of at least one symptom (i.e., fast or difficulty breathing). Across all 6 countries only around 30% of caregivers were aware of at least one of the two symptoms of pneumonia (i.e., fast or difficulty breathing). Our study shows that in the Democratic Republic of the Congo and Nigeria there was a positive association between knowledge and care seeking (P ≤ 0.01), even after adjusting for key variables (including wealth, residence, education). We found no association between caregivers' knowledge of pneumonia symptoms and actual care seeking for their child with symptoms of pneumonia in Central African Republic, Chad, Malawi, and Sierra Leone. These findings reveal an urgent need to increase community awareness of pneumonia symptoms, while simultaneously designing context specific strategies to address the fundamental challenges associated with timely care seeking.

Contradictions in Theorizing and Implementing Communities in Education

ERIC Educational Resources Information Center

Roth, Wolff-Michael; Lee, Yew-Jin

2006-01-01

Past educational improvement endeavors were fundamentally centered on the learner as an individual. This changed by the early 1990s after an increasing number of educators and researchers embraced sociocultural learning concepts such as "communities of practice," "communities of learners," and "knowledge-building communities." These ideas are…

Inventing the Electronic University

ERIC Educational Resources Information Center

Lewis, David W.

2015-01-01

Higher education is confronting a fundamental change. The transition from print on paper to digital and electronic technologies is transforming instruction, scholarly communication, and the storage and preservation of knowledge. What is required is not the automation of old systems, but the restructuring of institutions. The drive for autonomy,…

Application of spatial pedotransfer functions to understand soil modulation of vegetation response to climate

USDA-ARS?s Scientific Manuscript database

A fundamental knowledge gap in understanding land-atmosphere interactions is accurate, high resolution spatial representation of soil physical and hydraulic properties. We present a novel approach to predict hydraulic soil parameters by combining digital soil mapping techniques with pedotransfer fun...

Engineering Education's Contribution to the Space Program.

ERIC Educational Resources Information Center

Stever, H. Guyford

1988-01-01

States that an expanding future in space requires new technology. Stresses that from engineering education, space requires people with a fundamental knowledge of modern science instruments, all engineering sciences, an appreciation and capability for detail and systems design, and an understanding of costs and competitiveness, machines, materials,…

Explanation and Prediction: Building a Unified Theory of Librarianship, Concept and Review.

ERIC Educational Resources Information Center

McGrath, William E.

2002-01-01

Develops a comprehensive, unified, explanatory theory of librarianship by first making an analogy to the unification of the fundamental forces of nature. Topics include dependent and independent variables; publishing; acquisitions; classification and organization of knowledge; storage, preservation, and collection management; collections; and…

Professionalism in Long-Term Care Settings

ERIC Educational Resources Information Center

Lubinski, Rosemary

2006-01-01

Speech-language pathologists who serve elders in a variety of long-term care settings have a variety of professional skills and responsibilities. Fundamental to quality service is knowledge of aging and communication changes and disorders associated with this process, institutional alternatives, and the changing nature of today's elders in…

Refrigeration Controls: Electrical & Mechanical; Appliance Repair 3: 9027.02.

ERIC Educational Resources Information Center

Dade County Public Schools, Miami, FL.

This booklet outlines a course designed to equip major appliance service students with the fundamental knowledge and understanding of procedures, basic electrical circuitry, and nomenclatures of components necessary in successfully tracing a circuit and repairing or replacing a malfunctioning component. Course content includes goals, specific…

Why Geography Matters.

ERIC Educational Resources Information Center

McDougall, Walter A.

2001-01-01

It is important to learn geography, yet most Americans leave school functionally illiterate in geography. Geography is fundamental to student maturation, the process of true education, and it is a springboard to every other science and humanities subject. Knowledge of maps and geographical information is crucial to the examination of economic,…

Theoretical Chemistry Comes Alive: Full Partner with Experiment.

ERIC Educational Resources Information Center

Goddard, William A., III

1985-01-01

The expected thrust for theoretical chemistry in the next decade will be to combine knowledge of fundamental chemical steps/interactions with advances in chemical dynamics, irreversible statistical mechanics, and computer technology to produce simulations of chemical systems with reaction site competition. A sample simulation (using the enzyme…

Adult Literacy Education: Program Evaluation and Learner Assessment. Information Series No. 338.

ERIC Educational Resources Information Center

Lytle, Susan L.; Wolfe, Marcie

Adult literacy programs need reliable information about program quality and effectiveness for accountability, improvement of practice, and expansion of knowledge. Evaluation and assessment reflect fundamental beliefs about adult learners, concepts of literacy, and educational settings. Resources for planning program evaluations include surveys,…

Elaborating on Threshold Concepts

ERIC Educational Resources Information Center

Rountree, Janet; Robins, Anthony; Rountree, Nathan

2013-01-01

We propose an expanded definition of Threshold Concepts (TCs) that requires the successful acquisition and internalisation not only of knowledge, but also its practical elaboration in the domains of applied strategies and mental models. This richer definition allows us to clarify the relationship between TCs and Fundamental Ideas, and to account…

Declarative memory: sleep protects new memories from interference.

PubMed

Norman, Kenneth A

2006-08-08

Interference is one of the most fundamental phenomena in memory research: acquiring new memories causes forgetting of other, related memories. A new study shows that sleep, interposed between learning episodes, can mitigate the extent to which new (post-sleep) learning interferes with recall of previously acquired knowledge.

Waterheaters and Dishwashers; Appliance Repair--Beginning: 9023.04.

ERIC Educational Resources Information Center

Dade County Public Schools, Miami, FL.

This course outline provides major appliance repair students with a fundamental knowledge of waterheaters and dishwashers, and is intended to guide their performance of duties as technicians. Covering the complete electrical and mechanical functions of heaters and dishwashers, the course outline includes goals, specific block objectives,…

Becoming a Psychotherapist: Issues of Identity Transformation.

ERIC Educational Resources Information Center

Hart, Anton H.

Becoming a psychotherapist involves more than acquiring skills and knowledge. It involves a change in the way the psychotherapist trainee sees himself. Proponents of most psychotherapeutic modalities acknowledge that a clinician's fundamental clinical tool is his self. The therapist's self is involved in the spontaneous process of…

Globalisation and Translation: A Theoretical Approach

ERIC Educational Resources Information Center

Bielsa, Esperanca

2005-01-01

Two fundamental features of globalisation are the overcoming of spatial barriers and the centrality of knowledge and information. These developments, which result in the increased mobility of people and objects and a heightened contact between different linguistic communities (mass tourism, migration, information and media flows) signal, in spite…

Assessing Statistical Competencies in Clinical and Translational Science Education: One Size Does Not Fit All

PubMed Central

Lindsell, Christopher J.; Welty, Leah J.; Mazumdar, Madhu; Thurston, Sally W.; Rahbar, Mohammad H.; Carter, Rickey E.; Pollock, Bradley H.; Cucchiara, Andrew J.; Kopras, Elizabeth J.; Jovanovic, Borko D.; Enders, Felicity T.

2014-01-01

Abstract Introduction Statistics is an essential training component for a career in clinical and translational science (CTS). Given the increasing complexity of statistics, learners may have difficulty selecting appropriate courses. Our question was: what depth of statistical knowledge do different CTS learners require? Methods For three types of CTS learners (principal investigator, co‐investigator, informed reader of the literature), each with different backgrounds in research (no previous research experience, reader of the research literature, previous research experience), 18 experts in biostatistics, epidemiology, and research design proposed levels for 21 statistical competencies. Results Statistical competencies were categorized as fundamental, intermediate, or specialized. CTS learners who intend to become independent principal investigators require more specialized training, while those intending to become informed consumers of the medical literature require more fundamental education. For most competencies, less training was proposed for those with more research background. Discussion When selecting statistical coursework, the learner's research background and career goal should guide the decision. Some statistical competencies are considered to be more important than others. Baseline knowledge assessments may help learners identify appropriate coursework. Conclusion Rather than one size fits all, tailoring education to baseline knowledge, learner background, and future goals increases learning potential while minimizing classroom time. PMID:25212569

A DVE Time Management Simulation and Verification Platform Based on Causality Consistency Middleware

NASA Astrophysics Data System (ADS)

Zhou, Hangjun; Zhang, Wei; Peng, Yuxing; Li, Sikun

During the course of designing a time management algorithm for DVEs, the researchers always become inefficiency for the distraction from the realization of the trivial and fundamental details of simulation and verification. Therefore, a platform having realized theses details is desirable. However, this has not been achieved in any published work to our knowledge. In this paper, we are the first to design and realize a DVE time management simulation and verification platform providing exactly the same interfaces as those defined by the HLA Interface Specification. Moreover, our platform is based on a new designed causality consistency middleware and might offer the comparison of three kinds of time management services: CO, RO and TSO. The experimental results show that the implementation of the platform only costs small overhead, and that the efficient performance of it is highly effective for the researchers to merely focus on the improvement of designing algorithms.

Autonomous learning based on cost assumptions: theoretical studies and experiments in robot control.

PubMed

Ribeiro, C H; Hemerly, E M

2000-02-01

Autonomous learning techniques are based on experience acquisition. In most realistic applications, experience is time-consuming: it implies sensor reading, actuator control and algorithmic update, constrained by the learning system dynamics. The information crudeness upon which classical learning algorithms operate make such problems too difficult and unrealistic. Nonetheless, additional information for facilitating the learning process ideally should be embedded in such a way that the structural, well-studied characteristics of these fundamental algorithms are maintained. We investigate in this article a more general formulation of the Q-learning method that allows for a spreading of information derived from single updates towards a neighbourhood of the instantly visited state and converges to optimality. We show how this new formulation can be used as a mechanism to safely embed prior knowledge about the structure of the state space, and demonstrate it in a modified implementation of a reinforcement learning algorithm in a real robot navigation task.

Composite structural materials

NASA Technical Reports Server (NTRS)

Ansell, G. S.; Loewy, R. G.; Wiberley, S. E.

1982-01-01

The promise of filamentary composite materials, whose development may be considered as entering its second generation, continues to generate intense interest and applications activity. Fiber reinforced composite materials offer substantially improved performance and potentially lower costs for aerospace hardware. Much progress has been achieved since the initial developments in the mid 1960's. Rather limited applications to primary aircraft structure have been made, however, mainly in a material-substitution mode on military aircraft, except for a few experiments currently underway on large passenger airplanes in commercial operation. To fulfill the promise of composite materials completely requires a strong technology base. NASA and AFOSR recognize the present state of the art to be such that to fully exploit composites in sophisticated aerospace structures, the technology base must be improved. This, in turn, calls for expanding fundamental knowledge and the means by which it can be successfully applied in design and manufacture.

What is the problem in problem-based learning in higher education mathematics

NASA Astrophysics Data System (ADS)

Dahl, Bettina

2018-01-01

Problem and Project-Based Learning (PBL) emphasise collaborate work on problems relevant to society and emphases the relation between theory and practice. PBL fits engineering students as preparation for their future professions but what about mathematics? Mathematics is not just applied mathematics, but it is also a body of abstract knowledge where the application in society is not always obvious. Does mathematics, including pure mathematics, fit into a PBL curriculum? This paper argues that it does for two reasons: (1) PBL resembles the working methods of research mathematicians. (2) The concept of society includes the society of researchers to whom theoretical mathematics is relevant. The paper describes two cases of university PBL projects in mathematics; one in pure mathematics and the other in applied mathematics. The paper also discusses that future engineers need to understand the world of mathematics as well as how engineers fit into a process of fundamental-research-turned-into-applied-science.