The Light Ion Pulsed Power Induction Accelerator for ETF

DTIC Science & Technology

1995-07-01

the technical development necessary to demonstrate scientific and engineering feasibility for fusion energy production with a reprated driver. In...order for ETF to be cost effective, the accelerator system must be able to drive several target chambers which will test various Inertial Fusion ... Energy (IFE) reactor technologies. We envision an elevator system positioning and removing multiple target chambers from the center area of the ion beam

Plasma Power Station with Quasi Spherical Direct Drive Capsule for Fusion Yield and Inverse Diode for Driver-Target Coupling

DOE PAGES

VanDevender, J. P.; Cuneo, M. E.; Slutz, S. A.; ...

2012-01-01

The Meier-Moir economic model for Pulsed Power Driven Inertial Fusion Energy shows at least two approaches for fusion energy at 7 to 8 cents/kw-hr: One with large yield at 0.1 Hz and presented by M. E. Cuneo at ICENES 2011 and one with smaller yield at 3 Hz presented in this paper. Both use very efficient and low cost Linear Transformer Drivers (LTDs) for the pulsed power. Here, we report the system configuration and end-to-end simulation for the latter option, which is called the Plasma Power Station (PPS), and report the first results on the two, least mature, enabling technologies:more » a magnetically driven Quasi Spherical Direct Drive (QSDD) capsule for the fusion yield and an Inverse Diode for coupling the driver to the target. In addition, we describe the issues and propose to address the issues with a prototype of the PPS on the Saturn accelerator and with experiments on a short pulse modification of the Z accelerator test the validity of simulations showing megajoule thermonuclear yield with DT on a modified Z.« less

Activation of theMercury Laser System: A Diode-Pumped Solid-State Laser Driver for Inertial Fusion

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bayramian, A J; Beach, R J; Bibeau, C

Initial measurements are reported for the Mercury laser system, a scalable driver for rep-rated inertial fusion energy. The performance goals include 10% electrical efficiency at 10 Hz and 100 J with a 2-10 ns pulse length. We report on the first Yb:S-FAP crystals grown to sufficient size for fabricating full size (4 x 6 cm) amplifier slabs. The first of four 160 kW (peak power) diode arrays and pump delivery systems were completed and tested with the following results: 5.5% power droop over a 0.75 ms pulse, 3.95 nm spectral linewidth, far field divergence of 14.0 mrad and 149.5 mradmore » in the microlensed and unmicrolensed directions respectively, and 83% optical-to-optical transfer efficiency through the pump delivery system.« less

Identification of TRA2B-DNAH5 fusion as a novel oncogenic driver in human lung squamous cell carcinoma

PubMed Central

Li, Fei; Fang, Zhaoyuan; Zhang, Jian; Li, Chen; Liu, Hongyan; Xia, Jufeng; Zhu, Hongwen; Guo, Chenchen; Qin, Zhen; Li, Fuming; Han, Xiangkun; Wang, Yuetong; Feng, Yan; Wang, Ye; Zhang, Wenjing; Wang, Zuoyun; Jin, Yujuan; Sun, Yihua; Wei, Wenyi; Zeng, Rong; Chen, Haiquan; Ji, Hongbin

2016-01-01

Lung squamous cell carcinoma (SCC) is one of the major subtypes of lung cancer. Our current knowledge of oncogenic drivers in this specific subtype of lung cancer is largely limited compared with lung adenocarcinoma (ADC). Through exon array analyses, molecular analyses and functional studies, we here identify the TRA2B-DNAH5 fusion as a novel oncogenic driver in lung SCC. We found that this gene fusion occurs exclusively in lung SCC (3.1%, 5/163), but not in lung ADC (0/119). Through mechanistic studies, we further revealed that this TRA2B-DNAH5 fusion promotes lung SCC malignant progression through regulating a SIRT6-ERK1/2-MMP1 signaling axis. We show that inhibition of ERK1/2 activation using selumetinib efficiently inhibits the growth of lung SCC with TRA2B-DNAH5 fusion expression. These findings improve our current knowledge of oncogenic drivers in lung SCC and provide a potential therapeutic strategy for lung SCC patients with TRA2B-DNAH5 fusion. PMID:27670699

RET fusion as a novel driver of medullary thyroid carcinoma.

PubMed

Grubbs, Elizabeth G; Ng, Patrick Kwok-Shing; Bui, Jacquelin; Busaidy, Naifa L; Chen, Ken; Lee, Jeffrey E; Lu, Xinyan; Lu, Hengyu; Meric-Bernstam, Funda; Mills, Gordon B; Palmer, Gary; Perrier, Nancy D; Scott, Kenneth L; Shaw, Kenna R; Waguespack, Steven G; Williams, Michelle D; Yelensky, Roman; Cote, Gilbert J

2015-03-01

Oncogenic RET tyrosine kinase gene fusions and activating mutations have recently been identified in lung cancers, prompting initiation of targeted therapy trials in this disease. Although RET point mutation has been identified as a driver of tumorigenesis in medullary thyroid carcinoma (MTC), no fusions have been described to date. We evaluated the role of RET fusion as an oncogenic driver in MTC. We describe a patient who died from aggressive sporadic MTC < 10 months after diagnosis. Her tumor was evaluated by means of next-generation sequencing, including an intronic capture strategy. A reciprocal translocation involving RET intron 12 was identified. The fusion was validated using a targeted break apart fluorescence in situ hybridization probe, and RNA sequencing confirmed the existence of an in-frame fusion transcript joining MYH13 exon 35 with RET exon 12. Ectopic expression of fusion product in a murine Ba/F3 cell reporter model established strong oncogenicity. Three tyrosine kinase inhibitors currently used to treat MTC in clinical practice blocked tumorigenic cell growth. This finding represents the report of a novel RET fusion, the first of its kind described in MTC. The finding of this potential novel oncogenic mechanism has clear implications for sporadic MTC, which in the majority of cases has no driver mutation identified. The presence of a RET fusion also provides a plausible target for RET tyrosine kinase inhibitor therapies.

Impact of Energy Gain and Subsystem Characteristics on Fusion Propulsion Performance

NASA Technical Reports Server (NTRS)

Chakrabarti, S.; Schmidt, G. R.

2001-01-01

Rapid transport of large payloads and human crews throughout the solar system requires propulsion systems having very high specific impulse (I(sub sp) > 10(exp 4) to 10(exp 5) s). It also calls for systems with extremely low mass-power ratios (alpha < 10(exp -1) kg/kW). Such low alpha are beyond the reach of conventional power-limited propulsion, but may be attainable with fusion and other nuclear concepts that produce energy within the propellant. The magnitude of energy gain must be large enough to sustain the nuclear process while still providing a high jet power relative to the massive energy-intensive subsystems associated with these concepts. This paper evaluates the impact of energy gain and subsystem characteristics on alpha. Central to the analysis are general parameters that embody the essential features of any 'gain-limited' propulsion power balance. Results show that the gains required to achieve alpha = 10(exp -1) kg/kW with foreseeable technology range from approximately 100 to over 2000, which is three to five orders of magnitude greater than current fusion state of the arL Sensitivity analyses point to the parameters exerting the most influence for either: (1) lowering a and improving mission performance or (2) relaxing gain requirements and reducing demands on the fusion process. The greatest impact comes from reducing mass and increasing efficiency of the thruster and subsystems downstream of the fusion process. High relative gain, through enhanced fusion processes or more efficient drivers and processors, is also desirable. There is a benefit in improving driver and subsystem characteristics upstream of the fusion process, but it diminishes at relative gains > 100.

Multispectral image-fused head-tracked vision system (HTVS) for driving applications

NASA Astrophysics Data System (ADS)

Reese, Colin E.; Bender, Edward J.

2001-08-01

Current military thermal driver vision systems consist of a single Long Wave Infrared (LWIR) sensor mounted on a manually operated gimbal, which is normally locked forward during driving. The sensor video imagery is presented on a large area flat panel display for direct view. The Night Vision and Electronics Sensors Directorate and Kaiser Electronics are cooperatively working to develop a driver's Head Tracked Vision System (HTVS) which directs dual waveband sensors in a more natural head-slewed imaging mode. The HTVS consists of LWIR and image intensified sensors, a high-speed gimbal, a head mounted display, and a head tracker. The first prototype systems have been delivered and have undergone preliminary field trials to characterize the operational benefits of a head tracked sensor system for tactical military ground applications. This investigation will address the advantages of head tracked vs. fixed sensor systems regarding peripheral sightings of threats, road hazards, and nearby vehicles. An additional thrust will investigate the degree to which additive (A+B) fusion of LWIR and image intensified sensors enhances overall driving performance. Typically, LWIR sensors are better for detecting threats, while image intensified sensors provide more natural scene cues, such as shadows and texture. This investigation will examine the degree to which the fusion of these two sensors enhances the driver's overall situational awareness.

Diode-pumped solid state lasers (DPSSLs) for Inertial Fusion Energy (IFE)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Krupke, W.F.

The status of diode-pumped, transverse-gas-flow cooled, Yb-S-FAP slab lasers is reviewed. Recently acquired experimental performance data are combined with a cost/performance IFE driver design code to define a cost-effective development path for IFE DPSSL drivers. Specific design parameters are described for the Mercury 100J/10 Hz, 1 kW system (first in the development scenario).

The Integrity bare-metal stent made by continuous sinusoid technology.

PubMed

Turco, Mark A

2011-05-01

The Integrity Coronary Stent System (Medtronic Vascular, CA, USA) is a low-profile, open-cell, cobalt-chromium-alloy advanced bare-metal iteration of the well-known Driver/Micro-Driver Coronary Stent System (Medtronic Vascular). The Integrity stent is made with a process called continuous sinusoid technology. This process allows stent construction via wrapping a single thin strand of wire around a mandrel in a sinusoid configuration, with laser fusion of adjacent crowns. The wire-forming process and fusion pattern provide the stent with a continuous preferential bending plane, intended to allow easier access to, and smoother tracking within, distal and tortuous vessels while radial strength is maintained. Continuous sinusoid technology represents innovation in the design of stent platforms and will provide a future stent platform for newer technology, including drug-eluting stent platforms, drug-filled stents and core wire stents.

Critical Science Issues for Direct Drive Inertial Fusion Energy

NASA Astrophysics Data System (ADS)

Dahlburg, Jill P.; Gardner, John H.; Schmitt, Andrew J.; Obenschain, S. P.

1998-09-01

There are several topics that require resolution prior to the construction of an Inertial Fusion Energy [IFE] laboratory Engineering Test Facility [ETF]: a pellet that produces high gain; a pellet fabrication system that cost-effectively and rapidly manufactures these pellets; a sufficiently uniform and durable high repetition-rate laser pellet driver; a practical target injection system that provides accurate pellet aiming; and, a target chamber that will survive the debris and radiation of repeated high-gain pellet implosions. In this summary we describe the science issues and opportunities that are involved in the design of a successful high gain direct drive Inertial Confinement Fusion [ICF] pellet.

Magnetized Target Fusion At General Fusion: An Overview

NASA Astrophysics Data System (ADS)

Laberge, Michel; O'Shea, Peter; Donaldson, Mike; Delage, Michael; Fusion Team, General

2017-10-01

Magnetized Target Fusion (MTF) involves compressing an initial magnetically confined plasma on a timescale faster than the thermal confinement time of the plasma. If near adiabatic compression is achieved, volumetric compression of 350X or more of a 500 eV target plasma would achieve a final plasma temperature exceeding 10 keV. Interesting fusion gains could be achieved provided the compressed plasma has sufficient density and dwell time. General Fusion (GF) is developing a compression system using pneumatic pistons to collapse a cavity formed in liquid metal containing a magnetized plasma target. Low cost driver, straightforward heat extraction, good tritium breeding ratio and excellent neutron protection could lead to a practical power plant. GF (65 employees) has an active plasma R&D program including both full scale and reduced scale plasma experiments and simulation of both. Although pneumatic driven compression of full scale plasmas is the end goal, present compression studies use reduced scale plasmas and chemically accelerated aluminum liners. We will review results from our plasma target development, motivate and review the results of dynamic compression field tests and briefly describe the work to date on the pneumatic driver front.

Multiview fusion for activity recognition using deep neural networks

NASA Astrophysics Data System (ADS)

Kavi, Rahul; Kulathumani, Vinod; Rohit, Fnu; Kecojevic, Vlad

2016-07-01

Convolutional neural networks (ConvNets) coupled with long short term memory (LSTM) networks have been recently shown to be effective for video classification as they combine the automatic feature extraction capabilities of a neural network with additional memory in the temporal domain. This paper shows how multiview fusion can be applied to such a ConvNet LSTM architecture. Two different fusion techniques are presented. The system is first evaluated in the context of a driver activity recognition system using data collected in a multicamera driving simulator. These results show significant improvement in accuracy with multiview fusion and also show that deep learning performs better than a traditional approach using spatiotemporal features even without requiring any background subtraction. The system is also validated on another publicly available multiview action recognition dataset that has 12 action classes and 8 camera views.

Driver Fusions and Their Implications in the Development and Treatment of Human Cancers.

PubMed

Gao, Qingsong; Liang, Wen-Wei; Foltz, Steven M; Mutharasu, Gnanavel; Jayasinghe, Reyka G; Cao, Song; Liao, Wen-Wei; Reynolds, Sheila M; Wyczalkowski, Matthew A; Yao, Lijun; Yu, Lihua; Sun, Sam Q; Chen, Ken; Lazar, Alexander J; Fields, Ryan C; Wendl, Michael C; Van Tine, Brian A; Vij, Ravi; Chen, Feng; Nykter, Matti; Shmulevich, Ilya; Ding, Li

2018-04-03

Gene fusions represent an important class of somatic alterations in cancer. We systematically investigated fusions in 9,624 tumors across 33 cancer types using multiple fusion calling tools. We identified a total of 25,664 fusions, with a 63% validation rate. Integration of gene expression, copy number, and fusion annotation data revealed that fusions involving oncogenes tend to exhibit increased expression, whereas fusions involving tumor suppressors have the opposite effect. For fusions involving kinases, we found 1,275 with an intact kinase domain, the proportion of which varied significantly across cancer types. Our study suggests that fusions drive the development of 16.5% of cancer cases and function as the sole driver in more than 1% of them. Finally, we identified druggable fusions involving genes such as TMPRSS2, RET, FGFR3, ALK, and ESR1 in 6.0% of cases, and we predicted immunogenic peptides, suggesting that fusions may provide leads for targeted drug and immune therapy. Copyright © 2018 The Authors. Published by Elsevier Inc. All rights reserved.

Multiple beam induction accelerators for heavy ion fusion

NASA Astrophysics Data System (ADS)

Seidl, Peter A.; Barnard, John J.; Faltens, Andris; Friedman, Alex; Waldron, William L.

2014-01-01

Induction accelerators are appealing for heavy-ion driven inertial fusion energy (HIF) because of their high efficiency and their demonstrated capability to accelerate high beam current (≥10 kA in some applications). For the HIF application, accomplishments and challenges are summarized. HIF research and development has demonstrated the production of single ion beams with the required emittance, current, and energy suitable for injection into an induction linear accelerator. Driver scale beams have been transported in quadrupole channels of the order of 10% of the number of quadrupoles of a driver. We review the design and operation of induction accelerators and the relevant aspects of their use as drivers for HIF. We describe intermediate research steps that would provide the basis for a heavy-ion research facility capable of heating matter to fusion relevant temperatures and densities, and also to test and demonstrate an accelerator architecture that scales well to a fusion power plant.

R-Spondin chromosome rearrangements drive Wnt-dependent tumour initiation and maintenance in the intestine.

PubMed

Han, Teng; Schatoff, Emma M; Murphy, Charles; Zafra, Maria Paz; Wilkinson, John E; Elemento, Olivier; Dow, Lukas E

2017-07-11

Defining the genetic drivers of cancer progression is a key in understanding disease biology and developing effective targeted therapies. Chromosome rearrangements are a common feature of human malignancies, but whether they represent bona fide cancer drivers and therapeutically actionable targets, requires functional testing. Here, we describe the generation of transgenic, inducible CRISPR-based mouse systems to engineer and study recurrent colon cancer-associated EIF3E-RSPO2 and PTPRK-RSPO3 chromosome rearrangements in vivo. We show that both Rspo2 and Rspo3 fusion events are sufficient to initiate hyperplasia and tumour development in vivo, without additional cooperating genetic events. Rspo-fusion tumours are entirely Wnt-dependent, as treatment with an inhibitor of Wnt secretion, LGK974, drives rapid tumour clearance from the intestinal mucosa without effects on normal intestinal crypts. Altogether, our study provides direct evidence that endogenous Rspo2 and Rspo3 chromosome rearrangements can initiate and maintain tumour development, and indicate a viable therapeutic window for LGK974 treatment of RSPO-fusion cancers.

Acoustically Driven Magnetized Target Fusion At General Fusion: An Overview

NASA Astrophysics Data System (ADS)

O'Shea, Peter; Laberge, M.; Donaldson, M.; Delage, M.; the Fusion Team, General

2016-10-01

Magnetized Target Fusion (MTF) involves compressing an initial magnetically confined plasma of about 1e23 m-3, 100eV, 7 Tesla, 20 cm radius, >100 μsec life with a 1000x volume compression in 100 microseconds. If near adiabatic compression is achieved, the final plasma of 1e26 m-3, 10keV, 700 Tesla, 2 cm radius, confined for 10 μsec would produce interesting fusion energy gain. General Fusion (GF) is developing an acoustic compression system using pneumatic pistons focusing a shock wave on the CT plasma in the center of a 3 m diameter sphere filled with liquid lead-lithium. Low cost driver, straightforward heat extraction, good tritium breeding ratio and excellent neutron protection could lead to a practical power plant. GF (65 employees) has an active plasma R&D program including both full scale and reduced scale plasma experiments and simulation of both. Although acoustic driven compression of full scale plasmas is the end goal, present compression studies use reduced scale plasmas and chemically accelerated Aluminum liners. We will review results from our plasma target development, motivate and review the results of dynamic compression field tests and briefly describe the work to date on the acoustic driver front.

Passive in-vehicle driver breath alcohol detection using advanced sensor signal acquisition and fusion.

PubMed

Ljungblad, Jonas; Hök, Bertil; Allalou, Amin; Pettersson, Håkan

2017-05-29

The research objective of the present investigation is to demonstrate the present status of passive in-vehicle driver breath alcohol detection and highlight the necessary conditions for large-scale implementation of such a system. Completely passive detection has remained a challenge mainly because of the requirements on signal resolution combined with the constraints of vehicle integration. The work is part of the Driver Alcohol Detection System for Safety (DADSS) program aiming at massive deployment of alcohol sensing systems that could potentially save thousands of American lives annually. The work reported here builds on earlier investigations, in which it has been shown that detection of alcohol vapor in the proximity of a human subject may be traced to that subject by means of simultaneous recording of carbon dioxide (CO 2 ) at the same location. Sensors based on infrared spectroscopy were developed to detect and quantify low concentrations of alcohol and CO 2 . In the present investigation, alcohol and CO 2 were recorded at various locations in a vehicle cabin while human subjects were performing normal in-step procedures and driving preparations. A video camera directed to the driver position was recording images of the driver's upper body parts, including the face, and the images were analyzed with respect to features of significance to the breathing behavior and breath detection, such as mouth opening and head direction. Improvement of the sensor system with respect to signal resolution including algorithm and software development, and fusion of the sensor and camera signals was successfully implemented and tested before starting the human study. In addition, experimental tests and simulations were performed with the purpose of connecting human subject data with repeatable experimental conditions. The results include occurrence statistics of detected breaths by signal peaks of CO 2 and alcohol. From the statistical data, the accuracy of breath alcohol estimation and timing related to initial driver routines (door opening, taking a seat, door closure, buckling up, etc.) can be estimated. The investigation confirmed the feasibility of passive driver breath alcohol detection using our present system. Trade-offs between timing and sensor signal resolution requirements will become critical. Further improvement of sensor resolution and system ruggedness is required before the results can be industrialized. It is concluded that a further important step toward completely passive detection of driver breath alcohol has been taken. If required, the sniffer function with alcohol detection capability can be combined with a subsequent highly accurate breath test to confirm the driver's legal status using the same sensor device. The study is relevant to crash avoidance, in particular driver monitoring systems and driver-vehicle interface design.

Performance and economics analysis of several laser fusion breeder fueled electricity generation systems

NASA Astrophysics Data System (ADS)

Berwald, D. H.; Maniscalco, J. A.

1981-01-01

The paper evaluates the potential of several future electricity generating systems composed of laser fusion-driven breeder reactors that provide fissile fuel for current technology light water fission power reactors (LWRs). The performance and economic feasibility of four fusion breeder blanket technologies for laser fusion drivers, namely uranium fast fission (UFF) blankets, uranium-thorium fast fission (UTFF) blankets, thorium fast fission (TFF) blankets and thorium-suppressed fission (TSF) blankets, are considered, including design and costs of two kinds, fixed (indirect) costs associated with plant capital and variable (direct) costs associated with fuel processing and operation and maintenance. Results indicate that the UTFF and TFF systems produce electricity most inexpensively and that any of the four breeder blanket concepts, including the TSF and UFF systems, can produce electricity for about 25 to 33% above the cost of electricity produced by a new LWR operating on the current once-through cycle. It is suggested that fusion breeders could supply most or all of our fissile fuel makeup requirements within about 20 years after commercial introduction.

Microfabricated Ion Beam Drivers for Magnetized Target Fusion

NASA Astrophysics Data System (ADS)

Persaud, Arun; Seidl, Peter; Ji, Qing; Ardanuc, Serhan; Miller, Joseph; Lal, Amit; Schenkel, Thomas

2015-11-01

Efficient, low-cost drivers are important for Magnetized Target Fusion (MTF). Ion beams offer a high degree of control to deliver the required mega joules of driver energy for MTF and they can be matched to several types of magnetized fuel targets, including compact toroids and solid targets. We describe an ion beam driver approach based on the MEQALAC concept (Multiple Electrostatic Quadrupole Array Linear Accelerator) with many beamlets in an array of micro-fabricated channels. The channels consist of a lattice of electrostatic quadrupoles (ESQ) for focusing and of radio-frequency (RF) electrodes for ion acceleration. Simulations with particle-in-cell and beam envelope codes predict >10x higher current densities compared to state-of-the-art ion accelerators. This increase results from dividing the total ion beam current up into many beamlets to control space charge forces. Focusing elements can be biased taking advantage of high breakdown electric fields in sub-mm structures formed using MEMS techniques (Micro-Electro-Mechanical Systems). We will present results on ion beam transport and acceleration in MEMS based beamlets. Acknowledgments: This work is supported by the U.S. DOE under Contract No. DE-AC02-05CH11231.

Remarks to SBS PCM based self-navigation of laser drivers

NASA Astrophysics Data System (ADS)

Kalal, M.; Matena, L.; Kong, HJ; Martinkova, M.; Cha, S.

2016-03-01

A novel technology of self-navigation of laser drivers on injected inertial fusion energy pellets employing phase conjugating mirrors based on stimulating Brillouin scattering was recently proposed. Its feasibility as well as various implications were gradually studied and working solutions to potential problems were always suggested. As this technology could help to overcome several burning key issues of inertial fusion (e.g., a sufficiently precise navigation of laser drivers on injected pellets in the case of a direct drive scheme and decreased requirements on high-repetition high-power lasers) it gradually started to attract a carefully measured tentative interest among the major inertial fusion oriented laboratories and projects. In this paper the next step in this research path will be reported. It concerns the resulting phase and amplitude structures created by multiple low energy drivers (glints) illuminating the pellet during the first stage of the process after their reflection and a subsequent superposition on the collecting/focusing final optics. It was demonstrated that with a large number of such drivers acting simultaneously from many angles the situation gets somewhat complicated and requires more detailed studies/suggestions of suitable configurations.

Co-fuse: a new class discovery analysis tool to identify and prioritize recurrent fusion genes from RNA-sequencing data.

PubMed

Paisitkriangkrai, Sakrapee; Quek, Kelly; Nievergall, Eva; Jabbour, Anissa; Zannettino, Andrew; Kok, Chung Hoow

2018-06-07

Recurrent oncogenic fusion genes play a critical role in the development of various cancers and diseases and provide, in some cases, excellent therapeutic targets. To date, analysis tools that can identify and compare recurrent fusion genes across multiple samples have not been available to researchers. To address this deficiency, we developed Co-occurrence Fusion (Co-fuse), a new and easy to use software tool that enables biologists to merge RNA-seq information, allowing them to identify recurrent fusion genes, without the need for exhaustive data processing. Notably, Co-fuse is based on pattern mining and statistical analysis which enables the identification of hidden patterns of recurrent fusion genes. In this report, we show that Co-fuse can be used to identify 2 distinct groups within a set of 49 leukemic cell lines based on their recurrent fusion genes: a multiple myeloma (MM) samples-enriched cluster and an acute myeloid leukemia (AML) samples-enriched cluster. Our experimental results further demonstrate that Co-fuse can identify known driver fusion genes (e.g., IGH-MYC, IGH-WHSC1) in MM, when compared to AML samples, indicating the potential of Co-fuse to aid the discovery of yet unknown driver fusion genes through cohort comparisons. Additionally, using a 272 primary glioma sample RNA-seq dataset, Co-fuse was able to validate recurrent fusion genes, further demonstrating the power of this analysis tool to identify recurrent fusion genes. Taken together, Co-fuse is a powerful new analysis tool that can be readily applied to large RNA-seq datasets, and may lead to the discovery of new disease subgroups and potentially new driver genes, for which, targeted therapies could be developed. The Co-fuse R source code is publicly available at https://github.com/sakrapee/co-fuse .

Progress In Magnetized Target Fusion Driven by Plasma Liners

NASA Technical Reports Server (NTRS)

Thio, Francis Y. C.; Kirkpatrick, Ronald C.; Knapp, Charles E.; Cassibry, Jason; Eskridge, Richard; Lee, Michael; Smith, James; Martin, Adam; Wu, S. T.; Schmidt, George;

Research on driver fatigue detection

NASA Astrophysics Data System (ADS)

Zhang, Ting; Chen, Zhong; Ouyang, Chao

2018-03-01

Driver fatigue is one of the main causes of frequent traffic accidents. In this case, driver fatigue detection system has very important significance in avoiding traffic accidents. This paper presents a real-time method based on fusion of multiple facial features, including eye closure, yawn and head movement. The eye state is classified as being open or closed by a linear SVM classifier trained using HOG features of the detected eye. The mouth state is determined according to the width-height ratio of the mouth. The head movement is detected by head pitch angle calculated by facial landmark. The driver's fatigue state can be reasoned by the model trained by above features. According to experimental results, drive fatigue detection obtains an excellent performance. It indicates that the developed method is valuable for the application of avoiding traffic accidents caused by driver's fatigue.

Effective World Modeling: Multisensor Data Fusion Methodology for Automated Driving

PubMed Central

Elfring, Jos; Appeldoorn, Rein; van den Dries, Sjoerd; Kwakkernaat, Maurice

2016-01-01

The number of perception sensors on automated vehicles increases due to the increasing number of advanced driver assistance system functions and their increasing complexity. Furthermore, fail-safe systems require redundancy, thereby increasing the number of sensors even further. A one-size-fits-all multisensor data fusion architecture is not realistic due to the enormous diversity in vehicles, sensors and applications. As an alternative, this work presents a methodology that can be used to effectively come up with an implementation to build a consistent model of a vehicle’s surroundings. The methodology is accompanied by a software architecture. This combination minimizes the effort required to update the multisensor data fusion system whenever sensors or applications are added or replaced. A series of real-world experiments involving different sensors and algorithms demonstrates the methodology and the software architecture. PMID:27727171

Study on ( n,t) Reactions of Zr, Nb and Ta Nuclei

NASA Astrophysics Data System (ADS)

Tel, E.; Yiğit, M.; Tanır, G.

2012-04-01

The world faces serious energy shortages in the near future. To meet the world energy demand, the nuclear fusion with safety, environmentally acceptability and economic is the best suited. Fusion is attractive as an energy source because of the virtually inexhaustible supply of fuel, the promise of minimal adverse environmental impact, and its inherent safety. Fusion will not produce CO2 or SO2 and thus will not contribute to global warming or acid rain. Furthermore, there are not radioactive nuclear waste problems in the fusion reactors. Although there have been significant research and development studies on the inertial and magnetic fusion reactor technology, there is still a long way to go to penetrate commercial fusion reactors to the energy market. Because, tritium self-sufficiency must be maintained for a commercial power plant. For self-sustaining (D-T) fusion driver tritium breeding ratio should be greater than 1.05. And also, the success of fusion power system is dependent on performance of the first wall, blanket or divertor systems. So, the performance of structural materials for fusion power systems, understanding nuclear properties systematic and working out of ( n,t) reaction cross sections are very important. Zirconium (Zr), Niobium (Nb) and Tantal (Ta) containing alloys are important structural materials for fusion reactors, accelerator-driven systems, and many other fields. In this study, ( n,t) reactions for some structural fusion materials such as 88,90,92,94,96Zr, 93,94,95Nb and 179,181Ta have been investigated. The calculated results are discussed andcompared with the experimental data taken from the literature.

The EML4-ALK oncogene: targeting an essential growth driver in human cancer.

PubMed

Mano, Hiroyuki

2015-01-01

Targeting of essential growth drivers represents an ideal approach to cancer treatment. To identify such molecules in clinical specimens, we developed a highly sensitive functional screening system based on the preparation of retroviral cDNA expression libraries. By screening such a library of lung adenocarcinoma with a focus formation assay, we discovered the EML4-ALK fusion-type oncogene. A small chromosomal inversion thus leads to fusion of the amino-terminal portion of the microtubule-associated protein EML4 to the intracellular kinase domain of ALK, a receptor-type protein tyrosine kinase. Constitutive dimerization of EML4-ALK mediated by a dimerization motif of EML4 results in kinase activation. Specific inhibitors of the kinase activity of ALK have been developed as therapeutic drugs for EML4-ALK-positive lung cancer, three of which (crizotinib, ceritinib, and alectinib) have already been approved for clinical use. An overall clinical response rate of 93.5% for alectinib has shown that agents that target essential growth drivers can become magic bullets for cancer treatment.

The EML4-ALK oncogene: targeting an essential growth driver in human cancer

PubMed Central

MANO, Hiroyuki

2015-01-01

Targeting of essential growth drivers represents an ideal approach to cancer treatment. To identify such molecules in clinical specimens, we developed a highly sensitive functional screening system based on the preparation of retroviral cDNA expression libraries. By screening such a library of lung adenocarcinoma with a focus formation assay, we discovered the EML4-ALK fusion-type oncogene. A small chromosomal inversion thus leads to fusion of the amino-terminal portion of the microtubule-associated protein EML4 to the intracellular kinase domain of ALK, a receptor-type protein tyrosine kinase. Constitutive dimerization of EML4-ALK mediated by a dimerization motif of EML4 results in kinase activation. Specific inhibitors of the kinase activity of ALK have been developed as therapeutic drugs for EML4-ALK–positive lung cancer, three of which (crizotinib, ceritinib, and alectinib) have already been approved for clinical use. An overall clinical response rate of 93.5% for alectinib has shown that agents that target essential growth drivers can become magic bullets for cancer treatment. PMID:25971657

Identifying and Tracking Pedestrians Based on Sensor Fusion and Motion Stability Predictions

PubMed Central

Musleh, Basam; García, Fernando; Otamendi, Javier; Armingol, José Mª; de la Escalera, Arturo

2010-01-01

The lack of trustworthy sensors makes development of Advanced Driver Assistance System (ADAS) applications a tough task. It is necessary to develop intelligent systems by combining reliable sensors and real-time algorithms to send the proper, accurate messages to the drivers. In this article, an application to detect and predict the movement of pedestrians in order to prevent an imminent collision has been developed and tested under real conditions. The proposed application, first, accurately measures the position of obstacles using a two-sensor hybrid fusion approach: a stereo camera vision system and a laser scanner. Second, it correctly identifies pedestrians using intelligent algorithms based on polylines and pattern recognition related to leg positions (laser subsystem) and dense disparity maps and u-v disparity (vision subsystem). Third, it uses statistical validation gates and confidence regions to track the pedestrian within the detection zones of the sensors and predict their position in the upcoming frames. The intelligent sensor application has been experimentally tested with success while tracking pedestrians that cross and move in zigzag fashion in front of a vehicle. PMID:22163639

Identifying and tracking pedestrians based on sensor fusion and motion stability predictions.

PubMed

Musleh, Basam; García, Fernando; Otamendi, Javier; Armingol, José Maria; de la Escalera, Arturo

2010-01-01

The lack of trustworthy sensors makes development of Advanced Driver Assistance System (ADAS) applications a tough task. It is necessary to develop intelligent systems by combining reliable sensors and real-time algorithms to send the proper, accurate messages to the drivers. In this article, an application to detect and predict the movement of pedestrians in order to prevent an imminent collision has been developed and tested under real conditions. The proposed application, first, accurately measures the position of obstacles using a two-sensor hybrid fusion approach: a stereo camera vision system and a laser scanner. Second, it correctly identifies pedestrians using intelligent algorithms based on polylines and pattern recognition related to leg positions (laser subsystem) and dense disparity maps and u-v disparity (vision subsystem). Third, it uses statistical validation gates and confidence regions to track the pedestrian within the detection zones of the sensors and predict their position in the upcoming frames. The intelligent sensor application has been experimentally tested with success while tracking pedestrians that cross and move in zigzag fashion in front of a vehicle.

R-Spondin chromosome rearrangements drive Wnt-dependent tumour initiation and maintenance in the intestine

PubMed Central

Han, Teng; Schatoff, Emma M.; Murphy, Charles; Zafra, Maria Paz; Wilkinson, John E.; Elemento, Olivier; Dow, Lukas E.

2017-01-01

Defining the genetic drivers of cancer progression is a key in understanding disease biology and developing effective targeted therapies. Chromosome rearrangements are a common feature of human malignancies, but whether they represent bona fide cancer drivers and therapeutically actionable targets, requires functional testing. Here, we describe the generation of transgenic, inducible CRISPR-based mouse systems to engineer and study recurrent colon cancer-associated EIF3E–RSPO2 and PTPRK–RSPO3 chromosome rearrangements in vivo. We show that both Rspo2 and Rspo3 fusion events are sufficient to initiate hyperplasia and tumour development in vivo, without additional cooperating genetic events. Rspo-fusion tumours are entirely Wnt-dependent, as treatment with an inhibitor of Wnt secretion, LGK974, drives rapid tumour clearance from the intestinal mucosa without effects on normal intestinal crypts. Altogether, our study provides direct evidence that endogenous Rspo2 and Rspo3 chromosome rearrangements can initiate and maintain tumour development, and indicate a viable therapeutic window for LGK974 treatment of RSPO-fusion cancers. PMID:28695896

Research on fatigue driving pre-warning system based on multi-information fusion

NASA Astrophysics Data System (ADS)

Zhao, Xuyang; Ye, Wenwu

2018-05-01

With the development of science and technology, transportation network has grown faster. But at the same time, the quantity of traffic accidents due to fatigue driving grows faster as well. In the meantime, fatigue driving has been one of the main causes of traffic accidents. Therefore, it is indispensable for us to study the detection of fatigue driving to help to driving safety. There are numerous approaches in discrimination method. Each type of method has its reasonable theoretical basis, but the disadvantages of traditional fatigue driving detection methods have been more and more obvious since we study the traditional physiology and psychological features of fatigue drivers. So we set up a new system based on multi-information fusion and pattern recognition theory. In the paper, the fatigue driving pre-warning system discriminates fatigue by analyzing the characteristic parameters, the parameters derived from the steering wheel angle, the driver's power of gripping and the heart rate. And the data analysis system is established based on fuzzy C-means clustering theory. Finally, KNN classifier is used to establish the relation between feature indexes and fatigue degree. It is verified that the system has the better accuracy, agility and robustness according to our confirmatory experiment.

Y fuse? Sex chromosome fusions in fishes and reptiles.

PubMed

Pennell, Matthew W; Kirkpatrick, Mark; Otto, Sarah P; Vamosi, Jana C; Peichel, Catherine L; Valenzuela, Nicole; Kitano, Jun

2015-05-01

Chromosomal fusion plays a recurring role in the evolution of adaptations and reproductive isolation among species, yet little is known of the evolutionary drivers of chromosomal fusions. Because sex chromosomes (X and Y in male heterogametic systems, Z and W in female heterogametic systems) differ in their selective, mutational, and demographic environments, those differences provide a unique opportunity to dissect the evolutionary forces that drive chromosomal fusions. We estimate the rate at which fusions between sex chromosomes and autosomes become established across the phylogenies of both fishes and squamate reptiles. Both the incidence among extant species and the establishment rate of Y-autosome fusions is much higher than for X-autosome, Z-autosome, or W-autosome fusions. Using population genetic models, we show that this pattern cannot be reconciled with many standard explanations for the spread of fusions. In particular, direct selection acting on fusions or sexually antagonistic selection cannot, on their own, account for the predominance of Y-autosome fusions. The most plausible explanation for the observed data seems to be (a) that fusions are slightly deleterious, and (b) that the mutation rate is male-biased or the reproductive sex ratio is female-biased. We identify other combinations of evolutionary forces that might in principle account for the data although they appear less likely. Our results shed light on the processes that drive structural changes throughout the genome.

Y Fuse? Sex Chromosome Fusions in Fishes and Reptiles

PubMed Central

Vamosi, Jana C.; Peichel, Catherine L.; Valenzuela, Nicole; Kitano, Jun

2015-01-01

Chromosomal fusion plays a recurring role in the evolution of adaptations and reproductive isolation among species, yet little is known of the evolutionary drivers of chromosomal fusions. Because sex chromosomes (X and Y in male heterogametic systems, Z and W in female heterogametic systems) differ in their selective, mutational, and demographic environments, those differences provide a unique opportunity to dissect the evolutionary forces that drive chromosomal fusions. We estimate the rate at which fusions between sex chromosomes and autosomes become established across the phylogenies of both fishes and squamate reptiles. Both the incidence among extant species and the establishment rate of Y-autosome fusions is much higher than for X-autosome, Z-autosome, or W-autosome fusions. Using population genetic models, we show that this pattern cannot be reconciled with many standard explanations for the spread of fusions. In particular, direct selection acting on fusions or sexually antagonistic selection cannot, on their own, account for the predominance of Y-autosome fusions. The most plausible explanation for the observed data seems to be (a) that fusions are slightly deleterious, and (b) that the mutation rate is male-biased or the reproductive sex ratio is female-biased. We identify other combinations of evolutionary forces that might in principle account for the data although they appear less likely. Our results shed light on the processes that drive structural changes throughout the genome. PMID:25993542

Heavy ion driven LMF design concept

NASA Astrophysics Data System (ADS)

Lee, E. P.

1991-08-01

The US Department of Energy has conducted a multi-year study of the requirements, designs and costs for a Laboratory Microfusion Facility (LMF). The primary purpose of the LMF would be testing of weapons physics and effects simulation using the output from microexplosions of inertial fusion pellets. It does not need a high repetition rate, efficient driver system as required by an electrical generating plant. However there would be so many features in common that the design, construction and operation of an LMF would considerably advance the application of inertial confinement fusion to energy production. The DOE study has concentrated particularly on the LMF driver, with design and component development undertaken at several national laboratories. Principally, these are LLNL (Solid State Laser), LANL (Gas Laser), and SNLA (Light Ions). Heavy Ions, although considered a possible LMF driver did not receive attention until the final stages of this study since its program management was through the Office of Energy Research rather than Defense Programs. During preparation of a summary report for the study it was decided that some account of heavy ions was needed for a complete survey of the driver candidates. A conceptual heavy ion LMF driver design was created for the DOE report which is titled LMC Phase II Design Concepts. The heavy ion driver did not receive the level of scrutiny of the other concepts and, unlike the others, no costs analysis by an independent contractor was performed. Since much of heavy ion driver design lore was brought together in this exercise it is worthwhile to make it available as an independent report. This is reproduced here as it appears in the DOE report.

Yb:YAG ceramic-based laser driver for Inertial Fusion Energy (IFE)

NASA Astrophysics Data System (ADS)

Vetrovec, John; Copeland, Drew A.; Litt, Amardeep S.

2016-03-01

We report on a new class of laser amplifiers for inertial confinement fusion (ICF) drivers based on a Yb:YAG ceramic disk in an edge-pumped configuration and cooled by a high-velocity gas flow. The Yb lasant offers very high efficiency and low waste heat. The ceramic host material has a thermal conductivity nearly 15-times higher than the traditionally used glass and it is producible in sizes suitable for a typical 10- to 20-kJ driver beam line. The combination of high lasant efficiency, low waste heat, edge-pumping, and excellent thermal conductivity of the host, enable operation at 10 to 20 Hz at over 20% wall plug efficiency while being comparably smaller and less costly than recently considered face-pumped alternative drivers using Nd:glass, Yb:S-FAP, and cryogenic Yb:YAG. Scalability of the laser driver over a broad range of sizes is presented.

Laser targets compensate for limitations in inertial confinement fusion drivers

NASA Astrophysics Data System (ADS)

Kilkenny, J. D.; Alexander, N. B.; Nikroo, A.; Steinman, D. A.; Nobile, A.; Bernat, T.; Cook, R.; Letts, S.; Takagi, M.; Harding, D.

2005-10-01

Success in inertial confinement fusion (ICF) requires sophisticated, characterized targets. The increasing fidelity of three-dimensional (3D), radiation hydrodynamic computer codes has made it possible to design targets for ICF which can compensate for limitations in the existing single shot laser and Z pinch ICF drivers. Developments in ICF target fabrication technology allow more esoteric target designs to be fabricated. At present, requirements require new deterministic nano-material fabrication on micro scale.

Kinase gene fusions in defined subsets of melanoma.

PubMed

Turner, Jacqueline; Couts, Kasey; Sheren, Jamie; Saichaemchan, Siriwimon; Ariyawutyakorn, Witthawat; Avolio, Izabela; Cabral, Ethan; Glogowska, Magdelena; Amato, Carol; Robinson, Steven; Hintzsche, Jennifer; Applegate, Allison; Seelenfreund, Eric; Gonzalez, Rita; Wells, Keith; Bagby, Stacey; Tentler, John; Tan, Aik-Choon; Wisell, Joshua; Varella-Garcia, Marileila; Robinson, William

2017-01-01

Genomic rearrangements resulting in activating kinase fusions have been increasingly described in a number of cancers including malignant melanoma, but their frequency in specific melanoma subtypes has not been reported. We used break-apart fluorescence in situ hybridization (FISH) to identify genomic rearrangements in tissues from 59 patients with various types of malignant melanoma including acral lentiginous, mucosal, superficial spreading, and nodular. We identified four genomic rearrangements involving the genes BRAF, RET, and ROS1. Of these, three were confirmed by Immunohistochemistry (IHC) or sequencing and one was found to be an ARMC10-BRAF fusion that has not been previously reported in melanoma. These fusions occurred in different subtypes of melanoma but all in tumors lacking known driver mutations. Our data suggest gene fusions are more common than previously thought and should be further explored particularly in melanomas lacking known driver mutations. © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Kinase Gene Fusions in Defined Subsets of Melanoma

PubMed Central

Turner, Jacqueline; Couts, Kasey; Sheren, Jamie; Saichaemchan, Siriwimon; Ariyawutyakorn, Witthawat; Avolio, Izabela; Cabral, Ethan; Glogowska, Magdelena; Amato, Carol; Robinson, Steven; Hintzsche, Jennifer; Applegate, Allison; Seelenfreund, Eric; Gonzalez, Rita; Wells, Keith; Bagby, Stacey; Tentler, John; Tan, Aik-Choon; Wisell, Joshua; Varella-Garcia, Marileila; Robinson, William

2017-01-01

Summary Genomic rearrangements resulting in activating kinase fusions have been increasingly described in a number of cancers including malignant melanoma, but their frequency in specific melanoma subtypes has not been reported. We used break-apart fluorescence in-situ hybridization (FISH) to identify genomic rearrangements in tissues from 59 patients with various types of malignant melanoma including acral lentiginous, mucosal, superficial spreading, and nodular. We identified four genomic rearrangements involving the genes BRAF, RET, and ROS1. Of these, three were confirmed by IHC or sequencing and one was found to be an ARMC10-BRAF fusion that has not been previously reported in melanoma. These fusions occurred in different subtypes of melanoma but all in tumors lacking known driver mutations. Our data suggest gene fusions are more common than previously thought-and should be further explored particularly in melanomas lacking known driver mutations. PMID:27864876

Perspective on the Role of Negative Ions and Ion-Ion Plasmas in Heavy Ion Fusion Science, Magnetic Fusion Energy,and Related Fields

DOE Office of Scientific and Technical Information (OSTI.GOV)

Grisham, L. R.; Kwan, J. W.

2008-08-01

Some years ago it was suggested that halogen negative ions could offer a feasible alternative path to positive ions as a heavy ion fusion driver beam which would not suffer degradation due to electron accumulation in the accelerator and beam transport system, and which could be converted to a neutral beam by photodetachment near the chamber entrance if desired. Since then, experiments have demonstrated that negative halogen beams can be extracted and accelerated away from the gas plume near the source with a surviving current density close to what could be achieved with a positive ion of similar mass, andmore » with comparable optical quality. In demonstrating the feasibility of halogen negative ions as heavy ion driver beams, ion - ion plasmas, an interesting and somewhat novel state of matter, were produced. These plasmas, produced near the extractor plane of the sources, appear, based upon many lines of experimental evidence, to consist of almost equal densities of positive and negative chlorine ions, with only a small component of free electrons. Serendipitously, the need to extract beams from this plasma for driver development provides a unique diagnostic tool to investigate the plasma, since each component - positive ions, negative ions, and electrons - can be extracted and measured separately. We discuss the relevance of these observations to understanding negative ion beam extraction from electronegative plasmas such as halogens, or the more familiar hydrogen of magnetic fusion ion sources. We suggest a concept which might improve negative hydrogen extraction by the addition of a halogen. The possibility and challenges of producing ion - ion plasmas with thin targets of halogens or, perhaps, salt, is briefly addressed.« less

Fusion of an Ensemble of Augmented Image Detectors for Robust Object Detection

PubMed Central

Wei, Pan; Anderson, Derek T.

2018-01-01

A significant challenge in object detection is accurate identification of an object’s position in image space, whereas one algorithm with one set of parameters is usually not enough, and the fusion of multiple algorithms and/or parameters can lead to more robust results. Herein, a new computational intelligence fusion approach based on the dynamic analysis of agreement among object detection outputs is proposed. Furthermore, we propose an online versus just in training image augmentation strategy. Experiments comparing the results both with and without fusion are presented. We demonstrate that the augmented and fused combination results are the best, with respect to higher accuracy rates and reduction of outlier influences. The approach is demonstrated in the context of cone, pedestrian and box detection for Advanced Driver Assistance Systems (ADAS) applications. PMID:29562609

Gyro Drift Correction for An Indirect Kalman Filter Based Sensor Fusion Driver.

PubMed

Lee, Chan-Gun; Dao, Nhu-Ngoc; Jang, Seonmin; Kim, Deokhwan; Kim, Yonghun; Cho, Sungrae

2016-06-11

Sensor fusion techniques have made a significant contribution to the success of the recently emerging mobile applications era because a variety of mobile applications operate based on multi-sensing information from the surrounding environment, such as navigation systems, fitness trackers, interactive virtual reality games, etc. For these applications, the accuracy of sensing information plays an important role to improve the user experience (UX) quality, especially with gyroscopes and accelerometers. Therefore, in this paper, we proposed a novel mechanism to resolve the gyro drift problem, which negatively affects the accuracy of orientation computations in the indirect Kalman filter based sensor fusion. Our mechanism focuses on addressing the issues of external feedback loops and non-gyro error elements contained in the state vectors of an indirect Kalman filter. Moreover, the mechanism is implemented in the device-driver layer, providing lower process latency and transparency capabilities for the upper applications. These advances are relevant to millions of legacy applications since utilizing our mechanism does not require the existing applications to be re-programmed. The experimental results show that the root mean square errors (RMSE) before and after applying our mechanism are significantly reduced from 6.3 × 10(-1) to 5.3 × 10(-7), respectively.

Engineering and Functional Characterization of Fusion Genes Identifies Novel Oncogenic Drivers of Cancer. | Office of Cancer Genomics

Cancer.gov

Oncogenic gene fusions drive many human cancers, but tools to more quickly unravel their functional contributions are needed. Here we describe methodology permitting fusion gene construction for functional evaluation. Using this strategy, we engineered the known fusion oncogenes, BCR-ABL1, EML4-ALK, and ETV6-NTRK3, as well as 20 previously uncharacterized fusion genes identified in TCGA datasets.

The HALNA project: Diode-pumped solid-state laser for inertial fusion energy

NASA Astrophysics Data System (ADS)

Kawashima, T.; Ikegawa, T.; Kawanaka, J.; Miyanaga, N.; Nakatsuka, M.; Izawa, Y.; Matsumoto, O.; Yasuhara, R.; Kurita, T.; Sekine, T.; Miyamoto, M.; Kan, H.; Furukawa, H.; Motokoshi, S.; Kanabe, T.

2006-06-01

High-enery, rep.-rated, diode-pumped solid-state laser (DPSSL) is one of leading candidates for inertial fusion energy driver (IFE) and related laser-driven high-field applications. The project for the development of IFE laser driver in Japan, HALNA (High Average-power Laser for Nuclear Fusion Application) at ILE, Osaka University, aims to demonstrate 100-J pulse energy at 10 Hz rep. rate with 5 times diffraction limited beam quality. In this article, the advanced solid-state laser technologies for one half scale of HALNA (50 J, 10 Hz) are presented including thermally managed slab amplifier of Nd:phosphate glass and zig-zag optical geometry, and uniform, large-area diode-pumping.

A Multiplexed Amplicon Approach for Detecting Gene Fusions by Next-Generation Sequencing.

PubMed

Beadling, Carol; Wald, Abigail I; Warrick, Andrea; Neff, Tanaya L; Zhong, Shan; Nikiforov, Yuri E; Corless, Christopher L; Nikiforova, Marina N

2016-03-01

Chromosomal rearrangements that result in oncogenic gene fusions are clinically important drivers of many cancer types. Rapid and sensitive methods are therefore needed to detect a broad range of gene fusions in clinical specimens that are often of limited quantity and quality. We describe a next-generation sequencing approach that uses a multiplex PCR-based amplicon panel to interrogate fusion transcripts that involve 19 driver genes and 94 partners implicated in solid tumors. The panel also includes control assays that evaluate the 3'/5' expression ratios of 12 oncogenic kinases, which might be used to infer gene fusion events when the partner is unknown or not included on the panel. There was good concordance between the solid tumor fusion gene panel and other methods, including fluorescence in situ hybridization, real-time PCR, Sanger sequencing, and other next-generation sequencing panels, because 40 specimens known to harbor gene fusions were correctly identified. No specific fusion reads were observed in 59 fusion-negative specimens. The 3'/5' expression ratio was informative for fusions that involved ALK, RET, and NTRK1 but not for BRAF or ROS1 fusions. However, among 37 ALK or RET fusion-negative specimens, four exhibited elevated 3'/5' expression ratios, indicating that fusions predicted solely by 3'/5' read ratios require confirmatory testing. Copyright © 2016 American Society for Investigative Pathology and the Association for Molecular Pathology. Published by Elsevier Inc. All rights reserved.

Forced Fusion in the Excited State of dtμ Muonic-Molecule and its Possible Drivers

NASA Astrophysics Data System (ADS)

Eskandari, M. R.; Faghihi, F.

It is shown that the cycling rate in the optimum tritium concentration in μCF and in the n=2, J=1, ν=0 state is 2.35 times higher than in n=1, J=ν=0 state. The methods to explore forced μCF of the n=2 state is discussed. Although the n=2 state shows to be more efficient in terms of its cycling rate, all suggested drivers seems to be useless with respect to the input energy requirement and short life-time of resonance states. It is shown that even using x-ray sources as a driver, and designing hybrid system, the suggested forced hybrid system energy gain is 13 and very good gain enhancement but still is far away to be of interest for practical applications with respect to very short life-time of resonance states.

Control of autonomous ground vehicles: a brief technical review

NASA Astrophysics Data System (ADS)

Babak, Shahian-Jahromi; Hussain, Syed A.; Karakas, Burak; Cetin, Sabri

2017-07-01

This paper presents a brief review of the developments achieved in autonomous vehicle systems technology. A concise history of autonomous driver assistance systems is presented, followed by a review of current state of the art sensor technology used in autonomous vehicles. Standard sensor fusion method that has been recently explored is discussed. Finally, advances in embedded software methodologies that define the logic between sensory information and actuation decisions are reviewed.

The design of a multimegawatt heat pipe radiator for an inertial fusion rocket powered manned Mars mission

NASA Technical Reports Server (NTRS)

Murray, K. A.

1988-01-01

A system of heat pipe radiators has been designed to provide waste heat rejection for an inertial fusion powered spacecraft capable of manned missions to other planets. The radiators are arrays of unfinned, arterial heat pipes operating at 1500 and 900 K. Liquid metal coolant carries up to 8000 MW of waste heat through feed pipes from on-board components (laser drivers and coil shield). The radiators do not rely on armor for protection from micrometeoroid penetration. An armored radiator design for this application with a 99 percent survivability would have a specific mass of 0.06 to 0.11 kg/kW at 1500 K. Instead, a segmentation of heat pipes is used, and bumpers are utilized to protect the feed pipes. This design reduces the specific mass to 0.015 to 0.04 kg/kW for the coil shield radiator (1500 K) and 0.06 to 0.12 kg/kW for the laser driver radiator (900 K).

Scalloped Hibachi and Vacuum-Pressure Foil for Electra: Electron Beam Pumped KrF Laser

DTIC Science & Technology

2007-06-01

confinement fusion energy (IFE) applications [1-8]. The foils are a critical part of this durability and efficiency. The electron beam, generated in a high...and A. W. Maschke, “Design descriptions of the Prometheus- L and -H inertial fusion energy drivers,” Fusion Engineering and Design, vol. 25, pp...inertial fusion energy ,” Fusion Engineering and Design, vol. 44, pp. 371-375, March 1999. [4] I. Okuda, e. Takahashi, and Y. Owadano, “A

Automotive Radar and Lidar Systems for Next Generation Driver Assistance Functions

NASA Astrophysics Data System (ADS)

Rasshofer, R. H.; Gresser, K.

2005-05-01

Automotive radar and lidar sensors represent key components for next generation driver assistance functions (Jones, 2001). Today, their use is limited to comfort applications in premium segment vehicles although an evolution process towards more safety-oriented functions is taking place. Radar sensors available on the market today suffer from low angular resolution and poor target detection in medium ranges (30 to 60m) over azimuth angles larger than ±30°. In contrast, Lidar sensors show large sensitivity towards environmental influences (e.g. snow, fog, dirt). Both sensor technologies today have a rather high cost level, forbidding their wide-spread usage on mass markets. A common approach to overcome individual sensor drawbacks is the employment of data fusion techniques (Bar-Shalom, 2001). Raw data fusion requires a common, standardized data interface to easily integrate a variety of asynchronous sensor data into a fusion network. Moreover, next generation sensors should be able to dynamically adopt to new situations and should have the ability to work in cooperative sensor environments. As vehicular function development today is being shifted more and more towards virtual prototyping, mathematical sensor models should be available. These models should take into account the sensor's functional principle as well as all typical measurement errors generated by the sensor.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kirkpatrick, R. C.

Nuclear fusion was discovered experimentally in 1933-34 and other charged particle nuclear reactions were documented shortly thereafter. Work in earnest on the fusion ignition problem began with Edward Teller's group at Los Alamos during the war years. His group quantified all the important basic atomic and nuclear processes and summarized their interactions. A few years later, the success of the early theory developed at Los Alamos led to very successful thermonuclear weapons, but also to decades of unsuccessful attempts to harness fusion as an energy source of the future. The reasons for this history are many, but it seems appropriatemore » to review some of the basics with the objective of identifying what is essential for success and what is not. This tutorial discusses only the conditions required for ignition in small fusion targets and how the target design impacts driver requirements. Generally speaking, the driver must meet the energy, power and power density requirements needed by the fusion target. The most relevant parameters for ignition of the fusion fuel are the minimum temperature and areal density (rhoR), but these parameters set secondary conditions that must be achieved, namely an implosion velocity, target size and pressure, which are interrelated. Despite the apparent simplicity of inertial fusion targets, there is not a single mode of fusion ignition, and the necessary combination of minimum temperature and areal density depends on the mode of ignition. However, by providing a magnetic field of sufficient strength, the conditions needed for fusion ignition can be drastically altered. Magnetized target fusion potentially opens up a vast parameter space between the extremes of magnetic and inertial fusion.« less

Pulsed power systems for environmental and industrial applications

NASA Astrophysics Data System (ADS)

Neau, E. L.

1994-10-01

The development of high peak power simulators, laser drivers, free electron lasers, and Inertial Confinement Fusion drivers is being extended to high average power short-pulse machines with the capabilities of performing new roles in environmental cleanup and industrial manufacturing processes. We discuss a new class of short-pulse, high average power accelerator that achieves megavolt electron and ion beams with 10's of kiloamperes of current and average power levels in excess of 100 kW. Large treatment areas are possible with these systems because kilojoules of energy are available in each output pulse. These systems can use large area x-ray converters for applications requiring grater depth of penetration such as food pasteurization and waste treatment. The combined development of this class of accelerators and applications, and Sandia National Laboratories, is called Quantum Manufacturing.

Integrated process modeling for the laser inertial fusion energy (LIFE) generation system

NASA Astrophysics Data System (ADS)

Meier, W. R.; Anklam, T. M.; Erlandson, A. C.; Miles, R. R.; Simon, A. J.; Sawicki, R.; Storm, E.

2010-08-01

A concept for a new fusion-fission hybrid technology is being developed at Lawrence Livermore National Laboratory. The primary application of this technology is base-load electrical power generation. However, variants of the baseline technology can be used to "burn" spent nuclear fuel from light water reactors or to perform selective transmutation of problematic fission products. The use of a fusion driver allows very high burn-up of the fission fuel, limited only by the radiation resistance of the fuel form and system structures. As a part of this process, integrated process models have been developed to aid in concept definition. Several models have been developed. A cost scaling model allows quick assessment of design changes or technology improvements on cost of electricity. System design models are being used to better understand system interactions and to do design trade-off and optimization studies. Here we describe the different systems models and present systems analysis results. Different market entry strategies are discussed along with potential benefits to US energy security and nuclear waste disposal. Advanced technology options are evaluated and potential benefits from additional R&D targeted at the different options is quantified.

Performance of the BATMAN RF source with a large racetrack shaped driver

NASA Astrophysics Data System (ADS)

Kraus, W.; Schiesko, L.; Wimmer, C.; Fantz, U.; Heinemann, B.

2017-08-01

In the negative ion sources in neutral beam injection systems (NBI) of future fusion reactors the plasma is generated in up to eight cylindrical RF sources ("drivers") from which it expands into the main volume. For these large sources, in particular those used in the future DEMO NBI, a high RF efficiency and operational reliability is required. To achieve this it could be favorable to substitute each pair of drivers by one larger one. To investigate this option the cylindrical driver of the BATMAN source at IPP Garching has been replaced by a large source with a racetrack shaped base area and tested using the same extraction system. The main differences are a five times larger source volume and another position of the Cs oven which is mounted onto the driver`s back plate and not onto the expansion volume. The conditioning characteristics and the plasma symmetry in front of the plasma grid were very similar. The extracted H- current densities jex are comparable to that achieved with the small driver at the same power. Because no saturation of jex occurred at 0.6 Pa at high power and the source allows high power operation, a maximum value 45.1 mA/cm2 at 103 kW has been reached. Sputtered Cu from the walls of the expansion volume affected the performance at low pressure, particularly in deuterium. The experiments will be therefore continued with Mo coating of all inner walls.

Transcriptome Meta-Analysis of Lung Cancer Reveals Recurrent Aberrations in NRG1 and Hippo Pathway Genes

PubMed Central

Dhanasekaran, Saravana M.; Balbin, O. Alejandro; Chen, Guoan; Nadal, Ernest; Kalyana-Sundaram, Shanker; Pan, Jincheng; Veeneman, Brendan; Cao, Xuhong; Malik, Rohit; Vats, Pankaj; Wang, Rui; Huang, Stephanie; Zhong, Jinjie; Jing, Xiaojun; Iyer, Matthew; Wu, Yi-Mi; Harms, Paul W.; Lin, Jules; Reddy, Rishindra; Brennan, Christine; Palanisamy, Nallasivam; Chang, Andrew C.; Truini, Anna; Truini, Mauro; Robinson, Dan R.; Beer, David G.; Chinnaiyan, Arul M.

2014-01-01

Lung cancer is emerging as a paradigm for disease molecular subtyping, facilitating targeted therapy based on driving somatic alterations. Here, we perform transcriptome analysis of 153 samples representing lung adenocarcinomas, squamous cell carcinomas, large cell lung cancer, adenoid cystic carcinomas and cell lines. By integrating our data with The Cancer Genome Atlas and published sources, we analyze 753 lung cancer samples for gene fusions and other transcriptomic alterations. We show that higher numbers of gene fusions is an independent prognostic factor for poor survival in lung cancer. Our analysis confirms the recently reported CD74-NRG1 fusion and suggests that NRG1, NF1 and Hippo pathway fusions may play important roles in tumors without known driver mutations. In addition, we observe exon skipping events in c-MET, which are attributable to splice site mutations. These classes of genetic aberrations may play a significant role in the genesis of lung cancers lacking known driver mutations. PMID:25531467

Fluid mechanics of fusion lasers. Final report, September 11, 1978-June 5, 1980

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shwartz, J; Kulkarny, V A; Ausherman, D A

1980-01-01

Flow loop components required to operate continuous-flow, repetitively-pulsed CO/sub 2/ and KrF laser drivers for ICF were identified and their performance requirements were specified. It was found that the laser flow loops can have a major effect on the laser beam quality and overall efficiency. The pressure wave suppressor was identified as the most critical flow loop component. The performance of vented side-wall suppressors was evaluated both analytically and experimentally and found capable of meeting the performance requirements of the CO/sub 2/ and KrF fusion lasers. All other laser flow loop components are essentially similar to those used in conventional,more » low speed wind tunnels and are therefore well characterized and can be readily incorporated into fusion laser flow systems designs.« less

Accelerator and Fusion Research Division. Annual report, October 1978-September 1979

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1980-03-01

Topics covered include: Super HILAC and Bevalac operations; high intensity uranium beams line item; advanced high charge state ion source; 184-inch synchrocyclotron; VENUS project; positron-electron project; high field superconducting accelerator magnets; beam cooling; accelerator theory; induction linac drivers; RF linacs and storage rings; theory; neutral beam systems development; experimental atomic physics; neutral beam plasma research; plasma theory; and the Tormac project. (GHT)

IFE Chamber Technology - Status and Future Challenges

DOE Office of Scientific and Technical Information (OSTI.GOV)

Meier, W.R.; Raffray, A.R.; Abdel-Khalik, S.I.

2003-07-15

Significant progress has been made on addressing critical issues for inertial fusion energy (IFE) chambers for heavy-ion, laser and Z-pinch drivers. A variety of chamber concepts are being investigated including drywall (currently favored for laser IFE), wetted-wall (applicable to both laser and ion drivers), and thick-liquid-wall (favored by heavy ion and z-pinch drivers). Recent progress and remaining challenges in developing IFE chambers are reviewed.

Pulse shaping and energy storage capabilities of angularly multiplexed KrF laser fusion drivers

NASA Astrophysics Data System (ADS)

Lehmberg, R. H.; Giuliani, J. L.; Schmitt, A. J.

2009-07-01

This paper describes a rep-rated multibeam KrF laser driver design for the 500kJ Inertial Fusion test Facility (FTF) recently proposed by NRL, then models its optical pulse shaping capabilities using the ORESTES laser kinetics code. It describes a stable and reliable iteration technique for calculating the required precompensated input pulse shape that will achieve the desired output shape, even when the amplifiers are heavily saturated. It also describes how this precompensation technique could be experimentally implemented in real time on a reprated laser system. The simulations show that this multibeam system can achieve a high fidelity pulse shaping capability, even for a high gain shock ignition pulse whose final spike requires output intensities much higher than the ˜4MW/cm2 saturation levels associated with quasi-cw operation; i.e., they show that KrF can act as a storage medium even for pulsewidths of ˜1ns. For the chosen pulse, which gives a predicted fusion energy gain of ˜120, the simulations predict the FTF can deliver a total on-target energy of 428kJ, a peak spike power of 385TW, and amplified spontaneous emission prepulse contrast ratios IASE/I<3×10-7 in intensity and FASE/F<1.5×10-5 in fluence. Finally, the paper proposes a front-end pulse shaping technique that combines an optical Kerr gate with cw 248nm light and a 1μm control beam shaped by advanced fiber optic technology, such as the one used in the National Ignition Facility (NIF) laser.

Inertially confined fusion using heavy ion drivers

DOE Office of Scientific and Technical Information (OSTI.GOV)

Herrmannsfeldt, W.B.; Bangerter, R.O.; Bock, R.

1991-10-01

The various technical issues of HIF will be briefly reviewed in this paper. It will be seen that there are numerous areas in common in all the approaches to HIF. In the recent International Symposium on Heavy Ion Inertial Fusion, the attendees met in specialized workshop sessions to consider the needs for research in each area. Each of the workshop groups considered the key questions of this report: (1) Is this an appropriate time for international collaboration in HIF (2) Which problems are most appropriate for such collaboration (3) Can the sharing of target design information be set aside untilmore » other driver and systems issues are better resolved, by which time it might be supposed that there could be a relaxation of classification of target issues (4) What form(s) of collaboration are most appropriate, e.g., bilateral or multilateral (5) Can international collaboration be sensibly attempted without significant increases in funding for HIF The authors of this report share the conviction that collaboration on a broad scale is mandatory for HIF to have the resources, both financial and personnel, to progress to a demonstration experiment. Ultimately it may be possible for a single driver with the energy, power, focusibility, and pulse shape to satisfy the needs of the international community for target physics research. Such a facility could service multiple experimental chambers with a variety of beam geometries and target concepts.« less

Inertially confined fusion using heavy ion drivers

DOE Office of Scientific and Technical Information (OSTI.GOV)

Herrmannsfeldt, W.B.; Bangerter, R.O.; Bock, R.

1991-10-01

The various technical issues of HIF will be briefly reviewed in this paper. It will be seen that there are numerous areas in common in all the approaches to HIF. In the recent International Symposium on Heavy Ion Inertial Fusion, the attendees met in specialized workshop sessions to consider the needs for research in each area. Each of the workshop groups considered the key questions of this report: (1) Is this an appropriate time for international collaboration in HIF? (2) Which problems are most appropriate for such collaboration? (3) Can the sharing of target design information be set aside untilmore » other driver and systems issues are better resolved, by which time it might be supposed that there could be a relaxation of classification of target issues? (4) What form(s) of collaboration are most appropriate, e.g., bilateral or multilateral? (5) Can international collaboration be sensibly attempted without significant increases in funding for HIF? The authors of this report share the conviction that collaboration on a broad scale is mandatory for HIF to have the resources, both financial and personnel, to progress to a demonstration experiment. Ultimately it may be possible for a single driver with the energy, power, focusibility, and pulse shape to satisfy the needs of the international community for target physics research. Such a facility could service multiple experimental chambers with a variety of beam geometries and target concepts.« less

Fusion Ignition Rocket Engine with Ballistic Ablative Lithium Liner

NASA Technical Reports Server (NTRS)

Martin, Adam; Eskridge, Richard; Fimognari, Peter J., III.

2005-01-01

Thermo-nuclear fusion may be the key to a high Isp, high specific power (low alpha) propulsion system. In a fusion system energy is liberated within, and imparted directly to, the propellant. In principle, this can overcome the performance limitations inherent in systems that require thermal power transfer across a material boundary, and/or multiple power conversion stages (NTR, NEP). A thermo-nuclear propulsion system, which attempts to overcome some of the problems inherent in the ORION concept, is described. A passive tapered liner is launched behind a vehicle, through a hole in a pusher-plate, that is connected to the vehicle by a shock-absorbing mechanism. A dense FRC plasmoid is then accelerated to high velocity (in excess of 1,000 km/s) and shot through the hole into the liner, when it has reached a given point down-range. The kinetic energy of the FRC is converted into thermal and magnetic-field energy, igniting a fusion bum in the magnetically confined plasma. The fusion reaction serves as an ignition source for the liner, which is made out of detonable materials. The energy liberated in this process is converted to thrust by the pusher-plate, as in the classic ORION concept. However with this concept, the vehicle does not carry a magazine of pre-fabricated pulse-units. A magnetic nozzle may also be used, in place of the pusher-plate. Estimates of the conditions needed to achieve a sufficient gain will be presented, along with a description of the driver characteristics. The incorporation of this concept into the propulsion system of a spacecraft will also be discussed.

Recent developments in high average power driver technology

DOE Office of Scientific and Technical Information (OSTI.GOV)

Prestwich, K.R.; Buttram, M.T.; Rohwein, G.J>

1979-01-01

Inertial confinement fusion (ICF) reactors will require driver systems operating with tens to hundreds of megawatts of average power. The pulse power technology that will be required to build such drivers is in a primitive state of development. Recent developments in repetitive pulse power are discussed. A high-voltage transformer has been developed and operated at 3 MV in a single pulse experiment and is being tested at 1.5 MV, 5 kj and 10 pps. A low-loss, 1 MV, 10 kj, 10 pps Marx generator is being tested. Test results from gas-dynamic spark gaps that operate both in the 100 kVmore » and 700 kV range are reported. A 250 kV, 1.5 kA/cm/sup 2/, 30 ns electron beam diode has operated stably for 1.6 x 10/sup 5/ pulses.« less

Improving CAR Navigation with a Vision-Based System

NASA Astrophysics Data System (ADS)

Kim, H.; Choi, K.; Lee, I.

2015-08-01

The real-time acquisition of the accurate positions is very important for the proper operations of driver assistance systems or autonomous vehicles. Since the current systems mostly depend on a GPS and map-matching technique, they show poor and unreliable performance in blockage and weak areas of GPS signals. In this study, we propose a vision oriented car navigation method based on sensor fusion with a GPS and in-vehicle sensors. We employed a single photo resection process to derive the position and attitude of the camera and thus those of the car. This image georeferencing results are combined with other sensory data under the sensor fusion framework for more accurate estimation of the positions using an extended Kalman filter. The proposed system estimated the positions with an accuracy of 15 m although GPS signals are not available at all during the entire test drive of 15 minutes. The proposed vision based system can be effectively utilized for the low-cost but high-accurate and reliable navigation systems required for intelligent or autonomous vehicles.

Improving Car Navigation with a Vision-Based System

NASA Astrophysics Data System (ADS)

Kim, H.; Choi, K.; Lee, I.

2015-08-01

The real-time acquisition of the accurate positions is very important for the proper operations of driver assistance systems or autonomous vehicles. Since the current systems mostly depend on a GPS and map-matching technique, they show poor and unreliable performance in blockage and weak areas of GPS signals. In this study, we propose a vision oriented car navigation method based on sensor fusion with a GPS and in-vehicle sensors. We employed a single photo resection process to derive the position and attitude of the camera and thus those of the car. This image georeferencing results are combined with other sensory data under the sensor fusion framework for more accurate estimation of the positions using an extended Kalman filter. The proposed system estimated the positions with an accuracy of 15 m although GPS signals are not available at all during the entire test drive of 15 minutes. The proposed vision based system can be effectively utilized for the low-cost but high-accurate and reliable navigation systems required for intelligent or autonomous vehicles.

The Mercury Project: A High Average Power, Gas-Cooled Laser For Inertial Fusion Energy Development

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bayramian, A; Armstrong, P; Ault, E

Hundred-joule, kilowatt-class lasers based on diode-pumped solid-state technologies, are being developed worldwide for laser-plasma interactions and as prototypes for fusion energy drivers. The goal of the Mercury Laser Project is to develop key technologies within an architectural framework that demonstrates basic building blocks for scaling to larger multi-kilojoule systems for inertial fusion energy (IFE) applications. Mercury has requirements that include: scalability to IFE beamlines, 10 Hz repetition rate, high efficiency, and 10{sup 9} shot reliability. The Mercury laser has operated continuously for several hours at 55 J and 10 Hz with fourteen 4 x 6 cm{sup 2} ytterbium doped strontiummore » fluoroapatite (Yb:S-FAP) amplifier slabs pumped by eight 100 kW diode arrays. The 1047 nm fundamental wavelength was converted to 523 nm at 160 W average power with 73% conversion efficiency using yttrium calcium oxy-borate (YCOB).« less

PBFA II, a 100 TW Pulsed Power Driver for the Inertial Confinement Fusion Program

DTIC Science & Technology

1985-06-01

providing a 30 MV, 15 ns output pulse,which accelerates lithium ions. The ions will focus onto a pellet containing deuterium-tritium, producing fusion ... energy . Several research areas will be reviewed: low jitter, highly reliable 370 kJ Marx generators; highly synchronized gas switching at 5 MV; efficient

The role of inertial fusion energy in the energy marketplace of the 21st century and beyond

NASA Astrophysics Data System (ADS)

John Perkins, L.

The viability of inertial fusion in the 21st century and beyond will be determined by its ultimate cost, complexity, and development path relative to other competing, long term, primary energy sources. We examine this potential marketplace in terms of projections for population growth, energy demands, competing fuel sources and environmental constraints (CO 2), and show that the two competitors for inertial fusion energy (IFE) in the medium and long term are methane gas hydrates and advanced, breeder fission; both have potential fuel reserves that will last for thousands of years. Relative to other classes of fusion concepts, we argue that the single largest advantage of the inertial route is the perception by future customers that the IFE fusion power core could achieve credible capacity factors, a result of its relative simplicity, the decoupling of the driver and reactor chamber, and the potential to employ thick liquid walls. In particular, we show that the size, cost and complexity of the IFE reactor chamber is little different to a fission reactor vessel of the same thermal power. Therefore, relative to fission, because of IFE's tangible advantages in safety, environment, waste disposal, fuel supply and proliferation, our research in advanced targets and innovative drivers can lead to a certain, reduced-size driver at which future utility executives will be indifferent to the choice of an advanced fission plant or an advanced IFE power plant; from this point on, we have a competitive commercial product. Finally, given that the major potential customer for energy in the next century is the present developing world, we put the case for future IFE "reservations" which could be viable propositions providing sufficient reliability and redundancy can be realized for each modular reactor unit.

Kinase impact assessment in the landscape of fusion genes that retain kinase domains: a pan-cancer study

PubMed Central

Kim, Pora; Jia, Peilin; Zhao, Zhongming

2018-01-01

Abstract Assessing the impact of kinase in gene fusion is essential for both identifying driver fusion genes (FGs) and developing molecular targeted therapies. Kinase domain retention is a crucial factor in kinase fusion genes (KFGs), but such a systematic investigation has not been done yet. To this end, we analyzed kinase domain retention (KDR) status in chimeric protein sequences of 914 KFGs covering 312 kinases across 13 major cancer types. Based on 171 kinase domain-retained KFGs including 101 kinases, we studied their recurrence, kinase groups, fusion partners, exon-based expression depth, short DNA motifs around the break points and networks. Our results, such as more KDR than 5′-kinase fusion genes, combinatorial effects between 3′-KDR kinases and their 5′-partners and a signal transduction-specific DNA sequence motif in the break point intronic sequences, supported positive selection on 3′-kinase fusion genes in cancer. We introduced a degree-of-frequency (DoF) score to measure the possible number of KFGs of a kinase. Interestingly, kinases with high DoF scores tended to undergo strong gene expression alteration at the break points. Furthermore, our KDR gene fusion network analysis revealed six of the seven kinases with the highest DoF scores (ALK, BRAF, MET, NTRK1, NTRK3 and RET) were all observed in thyroid carcinoma. Finally, we summarized common features of ‘effective’ (highly recurrent) kinases in gene fusions such as expression alteration at break point, redundant usage in multiple cancer types and 3′-location tendency. Collectively, our findings are useful for prioritizing driver kinases and FGs and provided insights into KFGs’ clinical implications. PMID:28013235

Investigation of Transmission Warming Technologies at Various Ambient Conditions

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jehlik, Forrest; Iliev, Simeon; Wood, Eric

This work details two approaches for evaluating transmission warming technology: experimental dynamometer testing and development of a simplified transmission efficiency model to quantify effects under varied real world ambient and driving conditions. Two vehicles were used for this investigation: a 2013 Ford Taurus and a 2011 Ford Fusion. The Taurus included a production transmission warming system and was tested over hot and cold ambient temperatures with the transmission warming system enabled and disabled. A robot driver was used to minimize driver variability and increase repeatability. Additionally the Fusion was tested cold and with the transmission pre-heated prior to completing themore » test cycles. These data were used to develop a simplified thermally responsive transmission model to estimate effects of transmission warming in real world conditions. For the Taurus, the fuel consumption variability within one standard deviation was shown to be under 0.5% for eight repeat Urban Dynamometer Driving Cycles (UDDS). These results were valid with the transmission warming system active or passive. Using the transmission warming system under 22 degrees C ambient temperature, fuel consumption reduction was shown to be 1.4%. For the Fusion, pre-warming the transmission reduced fuel consumption 2.5% for an urban drive cycle at -7 degrees C ambient temperature, with 1.5% of the 2.5% gain associated with the transmission, while consumption for the US06 test was shown to be reduced by 7% with 5.5% of the 7% gain associated with the transmission. It was found that engine warming due to conduction between the pre-heated transmission and the engine resulted in the remainder of the benefit. For +22 degrees C ambient tests, the pre-heated transmission was shown to reduce fuel consumption approximately 1% on an urban cycle, while no benefit was seen for the US06 cycle. The simplified modeling results showed gains in efficiency ranging from 0-1.5% depending on the ambient temperature and drive cycle.« less

Compact High-Current Heavy-Ion Injector

DOE Office of Scientific and Technical Information (OSTI.GOV)

Westenskow, G.A.; Grote, D.P.; Kwan, J.W.

2005-10-05

To provide a compact high-brightness heavy-ion beam source for Heavy Ion Fusion (HIF), we have been experimenting with merging multi-beamlets in an injector which uses an RF plasma source. An array of converging beamlets was used to produce a beam with the envelope radius, convergence, and ellipticity matched to an electrostatic quadrupole (ESQ) channel. Experimental results were in good quantitative agreement with simulation and have demonstrated the feasibility of this concept. The size of a driver-scale injector system using this approach will be several times smaller than one designed using traditional single large-aperture beams. The success of this experiment hasmore » possible significant economical and technical impacts on the architecture of HIF drivers.« less

Compact High-Current Heavy-Ion Injector

DOE Office of Scientific and Technical Information (OSTI.GOV)

Westenskow, G A; Grote, D P; Kwan, J W

2006-04-13

To provide a compact high-brightness heavy-ion beam source for Heavy Ion Fusion (HIF), we have been experimenting with merging multi-beamlets in an injector which uses an RF plasma source. An array of converging beamlets was use to produce a beam with the envelope radius, convergence, and ellipticity matched to an electrostatic quadrupole (ESQ) channel. Experimental results were in good quantitative agreement with simulation and have demonstrated the feasibility of this concept. The size of a driver-scale injector system using this approach will be several times smaller than one designed using traditional single large-aperture beams. The success of this experiment hasmore » possible significant economical and technical impacts on the architecture of HIF drivers.« less

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chicklis, E.P.; Folweiler, R.C.; Pollak, T.M.

This is a combined study of resonant pumped solid state lasers as fusion drivers, and the development of crystalline optical materials suitable for propagation of the high peak powers associated with laser fusion research. During this period of study the concept of rare gas halide lasers was first demonstrated by the lasing of Tm:YLF at 453 nm pumped by the 353 nm energy of XeF. Excited stata densities of 5 x 10/sup 18/ cm/sup -3/ have been attained and spectroscopic measurements show that up to 60% of the pump energy can be converted into useful stored energy. Alternative lasers andmore » pumping schemes are also discussed. In all cases the potential RGH/SS systems are evaluated in respect to internal efficiency and heat loading.« less

System study of a diode-pumped solid-state-laser driver for inertial fusion energy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Orth, C.D.; Payne, S.A.

The present a conceptual design of a diode-pumped solid-state-laser (DPSSL) driver for an inertial fusion energy (IFE) power plant based on the maximized cost of electricity (COE) as determined in a comprehensive systems study. This study contained extensive detail for all significant DPSSL physics and costs, plus published scaling relationships for the costs of the target chamber and the balance of plant (BOP). Our DPSSL design offers low development cost because it is modular, can be fully tested functionally at reduced scale, and is based on mature solid-state-laser technology. Most of the parameter values that we used are being verifiedmore » by experiments now in progress. Future experiments will address the few issues that remain. As a consequence, the economic and technical risk of our DPSSL driver concept is becoming rather low. Baseline performance at 1 GW{sub e} using a new gain medium [Yb{sup 3+}-doped Sr{sub 5}(PO{sub 4}){sub 3}F or Yb:S-FAP] includes a product of laser efficiency and target gain of {eta}G = 7, and a COE of 8.6 cents/kW{center_dot}h, although values of {eta}G {ge} 11 and COEs {le}6.6 cents/kW{center_dot}h are possible at double the assumed target gain of 76 at 3.7 MJ. We present a summary of our results, discuss why other more-common types of laser media do not perform as well as Yb:S-FAP, and present a simple model that shows where DPSSL development should proceed to reduce projected COEs.« less

Dynamic Confinement of ITER Plasma by O-Mode Driver at Electron Cyclotron Frequency Range

NASA Astrophysics Data System (ADS)

Stefan, V. Alexander

2009-05-01

A low B-field side launched electron cyclotron O-Mode driver leads to the dynamic rf confinement, in addition to rf turbulent heating, of ITER plasma. The scaling law for the local energy confinement time τE is evaluated (τE ˜ 3neTe/2Q, where (3/2) neTe is the local plasma thermal energy density and Q is the local rf turbulent heating rate). The dynamics of unstable dissipative trapped particle modes (DTPM) strongly coupled to Trivelpiece-Gould (T-G) modes is studied for gyrotron frequency 170GHz; power˜24 MW CW; and on-axis B-field ˜ 10T. In the case of dynamic stabilization of DTPM turbulence and for the heavily damped T-G modes, the energy confinement time scales as τE˜(I0)-2, whereby I0(W/m^2) is the O-Mode driver irradiance. R. Prater et. al., Nucl. Fusion 48, No 3 (March 2008). E. P. Velikhov, History of the Russian Tokamak and the Tokamak Thermonuclear Fusion Research Worldwide That Led to ITER (Documentary movie; Stefan Studios Int'l, La Jolla, CA, 2008; E. P. Velikhov, V. Stefan.) M N Rosenbluth, Phys. Scr. T2A 104-109 1982 B. B. Kadomtsev and O. P. Pogutse, Nucl. Fusion 11, 67 (1971).

Intravehicular, Short- and Long-Range Communication Information Fusion for Providing Safe Speed Warnings

PubMed Central

Jiménez, Felipe; Naranjo, Jose Eugenio; Serradilla, Francisco; Pérez, Elisa; Hernández, María Jose; Ruiz, Trinidad; Anaya, José Javier; Díaz, Alberto

2016-01-01

Inappropriate speed is a relevant concurrent factor in many traffic accidents. Moreover, in recent years, traffic accidents numbers in Spain have fallen sharply, but this reduction has not been so significant on single carriageway roads. These infrastructures have less equipment than high-capacity roads, therefore measures to reduce accidents on them should be implemented in vehicles. This article describes the development and analysis of the impact on the driver of a warning system for the safe speed on each road section in terms of geometry, the presence of traffic jams, weather conditions, type of vehicle and actual driving conditions. This system is based on an application for smartphones and includes knowledge of the vehicle position via Ground Positioning System (GPS), access to intravehicular information from onboard sensors through the Controller Area Network (CAN) bus, vehicle data entry by the driver, access to roadside information (short-range communications) and access to a centralized server with information about the road in the current and following sections of the route (long-range communications). Using this information, the system calculates the safe speed, recommends the appropriate speed in advance in the following sections and provides warnings to the driver. Finally, data are sent from vehicles to a server to generate new information to disseminate to other users or to supervise drivers’ behaviour. Tests in a driving simulator have been used to define the system warnings and Human Machine Interface (HMI) and final tests have been performed on real roads in order to analyze the effect of the system on driver behavior. PMID:26805839

Emerging molecular therapeutic targets for cholangiocarcinoma.

PubMed

Rizvi, Sumera; Gores, Gregory J

2017-09-01

Cholangiocarcinomas (CCAs) are diverse epithelial tumors arising from the liver or large bile ducts with features of cholangiocyte differentiation. CCAs are classified anatomically into intrahepatic (iCCA), perihilar (pCCA), and distal CCA (dCCA). Each subtype has distinct risk factors, molecular pathogenesis, therapeutic options, and prognosis. CCA is an aggressive malignancy with a poor overall prognosis and median survival of less than 2years in patients with advanced disease. Potentially curative surgical treatment options are limited to the subset of patients with early-stage disease. Presently, the available systemic medical therapies for advanced or metastatic CCA have limited therapeutic efficacy. Molecular alterations define the differences in biological behavior of each CCA subtype. Recent comprehensive genetic analysis has better characterized the genomic and transcriptomic landscape of each CCA subtype. Promising candidates for targeted, personalized therapy have emerged, including potential driver fibroblast growth factor receptor (FGFR) gene fusions and somatic mutations in isocitrate dehydrogenase (IDH)1/2 in iCCA, protein kinase cAMP-activated catalytic subunit alpha (PRKACA) or beta (PRKACB) gene fusions in pCCA, and ELF3 mutations in dCCA/ampullary carcinoma. A precision genomic medicine approach is dependent on an enhanced understanding of driver mutations in each subtype and stratification of patients according to their genetic drivers. We review the current genomic landscape of CCA, the potentially actionable molecular aberrations in each CCA subtype, and the role of immunotherapy in CCA. Copyright © 2017 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.

Recent advances and challenges for diode-pumped solid-state lasers as an inertial fusion energy driver candidate

DOE Office of Scientific and Technical Information (OSTI.GOV)

Payne, S.A.; Beach, R.J.; Bibeau, C.

We discuss how solid-state laser technology can serve in the interests of fusion energy beyond the goals of the National Ignition Facility (NIF), which is now being constructed to ignite a deuterium-tritium target to fusion conditions in the laboratory for the first time. We think that advanced solid-state laser technology can offer the repetition-rate and efficiency needed to drive a fusion power plant, in contrast to the single-shot character of NIF. As discuss below, we propose that a gas-cooled, diode-pumped Yb:S-FAP laser can provide a new paradigm for fusion laser technology leading into the next century.

On the utility of antiprotons as drivers for inertial confinement fusion

NASA Astrophysics Data System (ADS)

Perkins, L. John; Orth, Charles D.; Tabak, Max

2004-10-01

In contrast to the large mass, complexity and recirculating power of conventional drivers for inertial confinement fusion (ICF), antiproton annihilation offers a specific energy of 90 MJ µg-1 and thus a unique form of energy packaging and delivery. In principle, antiproton drivers could provide a profound reduction in system mass for advanced space propulsion by ICF. We examine the physics underlying the use of antiprotons ( \\bar{p} ) to drive various classes of high-yield ICF targets by the methods of volumetric ignition, hotspot ignition and fast ignition. The useable fraction of annihilation deposition energy is determined for both \\bar{p} -driven ablative compression and \\bar{p} -driven fast ignition, in association with zero- and one-dimensional target burn models. Thereby, we deduce scaling laws for the number of injected antiprotons required per capsule, together with timing and focal spot requirements. The kinetic energy of the injected antiproton beam required to penetrate to the desired annihilation point is always small relative to the deposited annihilation energy. We show that heavy metal seeding of the fuel and/or ablator is required to optimize local deposition of annihilation energy and determine that a minimum of ~3 × 1015 injected antiprotons will be required to achieve high yield (several hundred megajoules) in any target configuration. Target gains—i.e. fusion yields divided by the available p- \\bar{p} annihilation energy from the injected antiprotons ( 1.88\\,GeV/\\bar{p} )—range from ~3 for volumetric ignition targets to ~600 for fast ignition targets. Antiproton-driven ICF is a speculative concept, and the handling of antiprotons and their required injection precision—temporally and spatially—will present significant technical challenges. The storage and manipulation of low-energy antiprotons, particularly in the form of antihydrogen, is a science in its infancy and a large scale-up of antiproton production over present supply methods would be required to embark on a serious R&D programme for this application.

Somatic chromosomal engineering identifies BCAN-NTRK1 as a potent glioma driver and therapeutic target.

PubMed

Cook, Peter J; Thomas, Rozario; Kannan, Ram; de Leon, Esther Sanchez; Drilon, Alexander; Rosenblum, Marc K; Scaltriti, Maurizio; Benezra, Robert; Ventura, Andrea

2017-07-11

The widespread application of high-throughput sequencing methods is resulting in the identification of a rapidly growing number of novel gene fusions caused by tumour-specific chromosomal rearrangements, whose oncogenic potential remains unknown. Here we describe a strategy that builds upon recent advances in genome editing and combines ex vivo and in vivo chromosomal engineering to rapidly and effectively interrogate the oncogenic potential of genomic rearrangements identified in human brain cancers. We show that one such rearrangement, an microdeletion resulting in a fusion between Brevican (BCAN) and Neurotrophic Receptor Tyrosine Kinase 1 (NTRK1), is a potent oncogenic driver of high-grade gliomas and confers sensitivity to the experimental TRK inhibitor entrectinib. This work demonstrates that BCAN-NTRK1 is a bona fide human glioma driver and describes a general strategy to define the oncogenic potential of novel glioma-associated genomic rearrangements and to generate accurate preclinical models of this lethal human cancer.

Ways to improve the efficiency and reliability of radio frequency driven negative ion sources for fusion.

PubMed

Kraus, W; Briefi, S; Fantz, U; Gutmann, P; Doerfler, J

2014-02-01

Large RF driven negative hydrogen ion sources are being developed at IPP Garching for the future neutral beam injection system of ITER. The overall power efficiency of these sources is low, because for the RF power supply self-excited generators are utilized and the plasma is generated in small cylindrical sources ("drivers") and expands into the source main volume. At IPP experiments to reduce the primary power and the RF power required for the plasma production are performed in two ways: The oscillator generator of the prototype source has been replaced by a transistorized RF transmitter and two alternative driver concepts, a spiral coil, in which the field is concentrated by ferrites, which omits the losses by plasma expansion and a helicon source are being tested.

Intelligent on-board system for driving assistance

NASA Astrophysics Data System (ADS)

Rombaut, Michele; Le Fort-Piat, N.

1995-09-01

We present in this paper, an electronic copilot embedded in a real car. The system objective is to help the driver by sending alarms or warnings in order to avoid dangerous situtations. An onboard perception system based on CCD cameras and proprioceptive sensors is used ot provide information concerning the environment and the internal state of the vehicle. From this set of information, the copilot is able to analyze the situation and to generate adequate warnings to the driver according to the circumstances. The definition and the development of such a system deal with multisensor data fusion and supervision strategies. The framework of this work was the European Prometheus Pro-Art program. The electronic copilot has been integrated in a prototype vehicle called Prolab2. This French demonstrator integrates the works of nine research laboratories and two car companies: PSA and RENAULT. After a brief presentation of the global demonstrator, we present the two principal parts developed in our laboratory corresponding to the high level modules of the system: the dynamic data manager and the situation supervision.

Simple wave drivers: electric toothbrush, shaver and razor

NASA Astrophysics Data System (ADS)

Kağan Temiz, Burak; Yavuz, Ahmet

2018-05-01

This study was conducted to develop simple and low-cost wave drivers that can be used in experiments on string waves. These wave drivers were made using a toothbrush (Oral-B Vitality), an electric shaver (Braun 7505) and a razor (Gillette Fusion Proglide Power). A common feature of all of these product is that they have vibration motors. In the experiments, string waves were generated by transferring these vibrations to a stretched string. By changing the tightness and length of the string, standing waves were generated, and various harmonics were observed.

Compact Torus plasma ring accelerator: a new type driver for inertial confinement fusion

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hartman, C.W.; Eddleman, J.L.; Hammer, J.H.

1986-08-22

We discuss the acceleration of magnetically-confined plasma rings to provide a driver for ICF. The acceleration of plasma rings is predicted to be efficient and following focusing, to generate ion-bombardment power in the range 10/sup 15/ to 10/sup 16/ W/cm/sup 2/ at a total deposition energy of multimegajoules. The simplicity of plasma ring accelerator suggests that a 5 MJ (on target) driver would cost in the range 1 to 5 $/joule. First experimental tests of the accelerator are described.

LDRD final report on confinement of cluster fusion plasmas with magnetic fields.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Argo, Jeffrey W.; Kellogg, Jeffrey W.; Headley, Daniel Ignacio

2011-11-01

Two versions of a current driver for single-turn, single-use 1-cm diameter magnetic field coils have been built and tested at the Sandia National Laboratories for use with cluster fusion experiments at the University of Texas in Austin. These coils are used to provide axial magnetic fields to slow radial loss of electrons from laser-produced deuterium plasmas. Typical peak field strength achievable for the two-capacitor system is 50 T, and 200 T for the ten-capacitor system. Current rise time for both systems is about 1.7 {mu}s, with peak current of 500 kA and 2 MA, respectively. Because the coil must bemore » brought to the laser, the driver needs to be portable and drive currents in vacuum. The drivers are complete but laser-plasma experiments are still in progress. Therefore, in this report, we focus on system design, initial tests, and performance characteristics of the two-capacitor and ten-capacitors systems. The questions of whether a 200 T magnetic field can retard the breakup of a cluster-fusion plasma, and whether this field can enhance neutron production have not yet been answered. However, tools have been developed that will enable producing the magnetic fields needed to answer these questions. These are a two-capacitor, 400-kA system that was delivered to the University of Texas in 2010, and a 2-MA ten-capacitor system delivered this year. The first system allowed initial testing, and the second system will be able to produce the 200 T magnetic fields needed for cluster fusion experiments with a petawatt laser. The prototype 400-kA magnetic field driver system was designed and built to test the design concept for the system, and to verify that a portable driver system could be built that delivers current to a magnetic field coil in vacuum. This system was built copying a design from a fixed-facility, high-field machine at LANL, but made to be portable and to use a Z-machine-like vacuum insulator and vacuum transmission line. This system was sent to the University of Texas in Austin where magnetic fields up to 50 T have been produced in vacuum. Peak charge voltage and current for this system have been 100 kV and 490 kA. It was used this last year to verify injection of deuterium and surrogate clusters into these small, single-turn coils without shorting the coil. Initial test confirmed the need to insulate the inner surface of the coil, which requires that the clusters must be injected through small holes in an insulator. Tests with a low power laser confirmed that it is possible to inject clusters into the magnetic field coils through these holes without destroying the clusters. The university team also learned the necessity of maintaining good vacuum to avoid insulator, transmission line, and coil shorting. A 200-T, 2 MA system was also constructed using the experience from the first design to make the pulsed-power system more robust. This machine is a copy of the prototype design, but with ten 100-kV capacitors versus the two used in the prototype. It has additional inductance in the switch/capacitor unit to avoid breakdown seen in the prototype design. It also has slightly more inductance at the cable connection to the vacuum chamber. With this design we have been able to demonstrate 1 MA current into a 1 cm diameter coil with the vacuum chamber at air pressure. Circuit code simulations, including the additional inductance with the new design, agree well with the measured current at a charge voltage of 40 kV with a short circuit load, and at 50 kV with a coil. The code also predicts that with a charge voltage of 97 kV we will be able to get 2 MA into a 1 cm diameter coil, which will be sufficient for 200 T fields. Smaller diameter or multiple-turn coils will be able to achieve even higher fields, or be able to achieve 200-T fields with lower charge voltage. Work is now proceeding at the university under separate funding to verify operation at the 2-MA level, and to address issues of debris mitigation, measurement of the magnetic field, and operation in vacuum. We anticipate operation at full current with single-turn, magnetic field coils this fall, with 200 T experiments on the Texas Petawatt laser in the spring of 2012.« less

Stopping power in D6Li plasmas for target ignition studies

NASA Astrophysics Data System (ADS)

Cortez, Ross J.; Cassibry, Jason T.

2018-02-01

The ability to calculate the range of charged fusion products in a target is critical when estimating driver requirements. Additionally, charged particle ranges are a determining factor in the possibility that a burn front will propagate through the surrounding cold fuel layer, igniting the plasma. Performance parameters of the plasma, such as yield, gain, etc therefore rely on accurate knowledge of particle ranges and stopping power over a wide range of densities and temperatures. Further, this knowledge is essential in calculating ignition conditions for a given target design. In this paper, stopping power is calculated for DD and D6Li plasmas using a molecular dynamics based model. Emphasis is placed on solid D6Li which has been recently considered as a fuel option for fusion propulsion systems.

Discovering and understanding oncogenic gene fusions through data intensive computational approaches

PubMed Central

Latysheva, Natasha S.; Babu, M. Madan

2016-01-01

Abstract Although gene fusions have been recognized as important drivers of cancer for decades, our understanding of the prevalence and function of gene fusions has been revolutionized by the rise of next-generation sequencing, advances in bioinformatics theory and an increasing capacity for large-scale computational biology. The computational work on gene fusions has been vastly diverse, and the present state of the literature is fragmented. It will be fruitful to merge three camps of gene fusion bioinformatics that appear to rarely cross over: (i) data-intensive computational work characterizing the molecular biology of gene fusions; (ii) development research on fusion detection tools, candidate fusion prioritization algorithms and dedicated fusion databases and (iii) clinical research that seeks to either therapeutically target fusion transcripts and proteins or leverages advances in detection tools to perform large-scale surveys of gene fusion landscapes in specific cancer types. In this review, we unify these different—yet highly complementary and symbiotic—approaches with the view that increased synergy will catalyze advancements in gene fusion identification, characterization and significance evaluation. PMID:27105842

Classifying Particles By Acoustic Levitation

NASA Technical Reports Server (NTRS)

Barmatz, Martin B.; Stoneburner, James D.

1983-01-01

Separation technique well suited to material processing. Apparatus with rectangular-cross-section chamber used to measure equilibrium positions of low-density spheres in gravitational field. Vertical acoustic forces generated by two opposing compression drivers exciting fundamental plane-wave mode at 1.2 kHz. Additional horizontal drivers centered samples along vertical axis. Applications in fusion-target separation, biological separation, and manufacturing processes in liquid or gas media.

Method and apparatus for producing cryogenic targets

DOEpatents

Murphy, James T.; Miller, John R.

1984-01-01

An improved method and apparatus are given for producing cryogenic inertially driven fusion targets in the fast isothermal freezing (FIF) method. Improved coupling efficiency and greater availability of volume near the target for diagnostic purposes and for fusion driver beam propagation result. Other embodiments include a new electrical switch and a new explosive detonator, all embodiments making use of a purposeful heating by means of optical fibers.

Identification of KIF5B-RET and GOPC-ROS1 fusions in lung adenocarcinomas through a comprehensive mRNA-based screen for tyrosine kinase fusions

PubMed Central

Suehara, Yoshiyuki; Arcila, Maria; Wang, Lu; Hasanovic, Adnan; Ang, Daphne; Ito, Tatsuo; Kimura, Yuki; Drilon, Alexander; Guha, Udayan; Rusch, Valerie; Kris, Mark G.; Zakowski, Maureen F.; Rizvi, Naiyer; Khanin, Raya; Ladanyi, Marc

2014-01-01

Background The mutually exclusive pattern of the major driver oncogenes in lung cancer suggests that other mutually exclusive oncogenes exist. We performed a systematic search for tyrosine kinase (TK) fusions by screening all TKs for aberrantly high RNA expression levels of the 3′ kinase domain (KD) exons relative to more 5′ exons. Methods We studied 69 patients (including 5 never smokers and 64 current or former smokers) with lung adenocarcinoma negative for all major mutations in KRAS, EGFR, BRAF, MEK1, and HER2, and for ALK fusions (termed “pan-negative”). A NanoString-based assay was designed to query the transcripts of 90 TKs at two points: 5′ to the KD and within the KD or 3′ to it. Tumor RNAs were hybridized to the NanoString probes and analyzed for outlier 3′ to 5′ expression ratios. Presumed novel fusion events were studied by rapid amplification of cDNA ends (RACE) and confirmatory RT-PCR and FISH. Results We identified 1 case each of aberrant 3′ to 5′ ratios in ROS1 and RET. RACE isolated a GOPC-ROS1 (FIG-ROS1) fusion in the former and a KIF5B-RET fusion in the latter, both confirmed by RT-PCR. The RET rearrangement was also confirmed by FISH. The KIF5B-RET patient was one of only 5 never smokers in this cohort. Conclusion The KIF5B-RET fusion defines an additional subset of lung cancer with a potentially targetable driver oncogene enriched in never smokers with “pan-negative” lung adenocarcinomas. We also report for the first time in lung cancer the GOPC-ROS1 fusion previously characterized in glioma. PMID:23052255

Comprehensive analysis of transcriptome variation uncovers known and novel driver events in T-cell acute lymphoblastic leukemia.

PubMed

Atak, Zeynep Kalender; Gianfelici, Valentina; Hulselmans, Gert; De Keersmaecker, Kim; Devasia, Arun George; Geerdens, Ellen; Mentens, Nicole; Chiaretti, Sabina; Durinck, Kaat; Uyttebroeck, Anne; Vandenberghe, Peter; Wlodarska, Iwona; Cloos, Jacqueline; Foà, Robin; Speleman, Frank; Cools, Jan; Aerts, Stein

2013-01-01

RNA-seq is a promising technology to re-sequence protein coding genes for the identification of single nucleotide variants (SNV), while simultaneously obtaining information on structural variations and gene expression perturbations. We asked whether RNA-seq is suitable for the detection of driver mutations in T-cell acute lymphoblastic leukemia (T-ALL). These leukemias are caused by a combination of gene fusions, over-expression of transcription factors and cooperative point mutations in oncogenes and tumor suppressor genes. We analyzed 31 T-ALL patient samples and 18 T-ALL cell lines by high-coverage paired-end RNA-seq. First, we optimized the detection of SNVs in RNA-seq data by comparing the results with exome re-sequencing data. We identified known driver genes with recurrent protein altering variations, as well as several new candidates including H3F3A, PTK2B, and STAT5B. Next, we determined accurate gene expression levels from the RNA-seq data through normalizations and batch effect removal, and used these to classify patients into T-ALL subtypes. Finally, we detected gene fusions, of which several can explain the over-expression of key driver genes such as TLX1, PLAG1, LMO1, or NKX2-1; and others result in novel fusion transcripts encoding activated kinases (SSBP2-FER and TPM3-JAK2) or involving MLLT10. In conclusion, we present novel analysis pipelines for variant calling, variant filtering, and expression normalization on RNA-seq data, and successfully applied these for the detection of translocations, point mutations, INDELs, exon-skipping events, and expression perturbations in T-ALL.

ROS1 fusions rarely overlap with other oncogenic drivers in non-small cell lung cancer

PubMed Central

Lin, Jessica J.; Ritterhouse, Lauren L.; Ali, Siraj M.; Bailey, Mark; Schrock, Alexa B.; Gainor, Justin F.; Ferris, Lorin A.; Mino-Kenudson, Mari; Miller, Vincent A.; Iafrate, Anthony J.; Lennerz, Jochen K.; Shaw, Alice T.

2017-01-01

Introduction Chromosomal rearrangements involving the ROS proto-oncogene 1 receptor tyrosine kinase gene (ROS1) define a distinct molecular subset of non-small cell lung cancer (NSCLC) with sensitivity to ROS1 inhibitors. Recent reports have suggested a significant overlap between ROS1 fusions and other oncogenic driver alterations, including mutations in epidermal growth factor receptor (EGFR) and KRAS proto-oncogene (KRAS). Methods We identified patients at our institution with ROS1-rearranged NSCLC who had undergone testing for genetic alterations in additional oncogenes, including EGFR, KRAS, and anaplastic lymphoma kinase (ALK). Clinicopathologic features and genetic testing results were reviewed. We also examined a separate database of ROS1-rearranged NSCLCs identified through a commercial FoundationOne assay. Results Among 62 patients with ROS1-rearranged NSCLC evaluated at our institution, none harbored concurrent ALK fusions (0%) or EGFR activating mutations (0%). KRAS mutations were detected in two cases (3.2%), one of which harbored a concurrent non-canonical KRAS I24N mutation of unknown biological significance. In a separate ROS1 FISH-positive case, targeted sequencing failed to confirm a ROS1 fusion, but instead identified a KRAS G13D mutation. No concurrent mutations in BRAF, ERBB2, PIK3CA, AKT1, or MAP2K1 were detected. Analysis of an independent dataset of 166 ROS1-rearranged NSCLCs identified by FoundationOne demonstrated rare cases with co-occurring driver mutations in EGFR (1/166) and KRAS (3/166), and no cases with co-occurring ROS1 and ALK rearrangements. Conclusions ROS1 rearrangements rarely overlap with alterations in EGFR, KRAS, ALK, or other targetable oncogenes in NSCLC. PMID:28088512

Tritium pellet injector for the tokamak fusion test reactor

NASA Astrophysics Data System (ADS)

Gouge, M. J.; Baylor, L. R.; Combs, S. K.; Fisher, P. W.; Foust, C. R.; Milora, S. L.

The tritium pellet injector (TPI) for the Tokamak Fusion Test Reactor (TFTR) will provide a tritium pellet fueling capability with pellet speeds in the 1- to 3-km/s range for the TFTR deuterium-tritium (D-T) plasma phase. An existing deuterium pellet injector (DPI) was modified at Oak Ridge National Laboratory (ORNL) to provide a four-shot, tritium-compatible, pipe-gun configuration with three upgraded single-stage pneumatic guns and a two-stage light gas gun driver. The TPI was designed for frozen pellets ranging in size from 3 to 4 mm in diameter in arbitrarily programmable firing sequences at tritium pellet speeds up to approximately 1.5 km/s for the three single-stage drivers and 2.5 to 3 km/s for the two-stage driver. Injector operation is controlled by a programmable logic controller (PLC). The new pipe-gun injector assembly was installed in the modified DPI guard vacuum box, and modifications were also made to the internals of the DPI vacuum injection line, including a new pellet diagnostics package. Assembly of these modified parts with existing DPI components was then completed and the TPI was tested at ORNL with deuterium pellets. Results of the testing program at ORNL are described. The TPI has been installed and operated on TFTR in support of the FY-92 deuterium plasma run period. In 1993, the tritium pellet injector will be retrofitted with a D-T fuel manifold and tritium gloveboxes and integrated into TFTR tritium processing systems to provide full tritium pellet capability.

Computer vision for driver assistance systems

NASA Astrophysics Data System (ADS)

Handmann, Uwe; Kalinke, Thomas; Tzomakas, Christos; Werner, Martin; von Seelen, Werner

1998-07-01

Systems for automated image analysis are useful for a variety of tasks and their importance is still increasing due to technological advances and an increase of social acceptance. Especially in the field of driver assistance systems the progress in science has reached a level of high performance. Fully or partly autonomously guided vehicles, particularly for road-based traffic, pose high demands on the development of reliable algorithms due to the conditions imposed by natural environments. At the Institut fur Neuroinformatik, methods for analyzing driving relevant scenes by computer vision are developed in cooperation with several partners from the automobile industry. We introduce a system which extracts the important information from an image taken by a CCD camera installed at the rear view mirror in a car. The approach consists of a sequential and a parallel sensor and information processing. Three main tasks namely the initial segmentation (object detection), the object tracking and the object classification are realized by integration in the sequential branch and by fusion in the parallel branch. The main gain of this approach is given by the integrative coupling of different algorithms providing partly redundant information.

Conceptual design of data acquisition and control system for two Rf driver based negative ion source for fusion R&D

NASA Astrophysics Data System (ADS)

Soni, Jigensh; Yadav, R. K.; Patel, A.; Gahlaut, A.; Mistry, H.; Parmar, K. G.; Mahesh, V.; Parmar, D.; Prajapati, B.; Singh, M. J.; Bandyopadhyay, M.; Bansal, G.; Pandya, K.; Chakraborty, A.

2013-02-01

Twin Source - An Inductively coupled two RF driver based 180 kW, 1 MHz negative ion source experimental setup is initiated at IPR, Gandhinagar, under Indian program, with the objective of understanding the physics and technology of multi-driver coupling. Twin Source [1] (TS) also provides an intermediate platform between operational ROBIN [2] [5] and eight RF drivers based Indian test facility -INTF [3]. A twin source experiment requires a central system to provide control, data acquisition and communication interface, referred as TS-CODAC, for which a software architecture similar to ITER CODAC core system has been decided for implementation. The Core System is a software suite for ITER plant system manufacturers to use as a template for the development of their interface with CODAC. The ITER approach, in terms of technology, has been adopted for the TS-CODAC so as to develop necessary expertise for developing and operating a control system based on the ITER guidelines as similar configuration needs to be implemented for the INTF. This cost effective approach will provide an opportunity to evaluate and learn ITER CODAC technology, documentation, information technology and control system processes, on an operational machine. Conceptual design of the TS-CODAC system has been completed. For complete control of the system, approximately 200 Nos. control signals and 152 acquisition signals are needed. In TS-CODAC, control loop time required is within the range of 5ms - 10 ms, therefore for the control system, PLC (Siemens S-7 400) has been chosen as suggested in the ITER slow controller catalog. For the data acquisition, the maximum sampling interval required is 100 micro second, and therefore National Instruments (NI) PXIe system and NI 6259 digitizer cards have been selected as suggested in the ITER fast controller catalog. This paper will present conceptual design of TS -CODAC system based on ITER CODAC Core software and applicable plant system integration processes.

Method and apparatus for producing cryogenic targets

DOEpatents

Murphy, J.T.; Miller, J.R.

1984-08-07

An improved method and apparatus are given for producing cryogenic inertially driven fusion targets in the fast isothermal freezing (FIF) method. Improved coupling efficiency and greater availability of volume near the target for diagnostic purposes and for fusion driver beam propagation result. Other embodiments include a new electrical switch and a new explosive detonator, all embodiments making use of a purposeful heating by means of optical fibers. 6 figs.

Decentralized real-time simulation of forest machines

NASA Astrophysics Data System (ADS)

Freund, Eckhard; Adam, Frank; Hoffmann, Katharina; Rossmann, Juergen; Kraemer, Michael; Schluse, Michael

2000-10-01

To develop realistic forest machine simulators is a demanding task. A useful simulator has to provide a close- to-reality simulation of the forest environment as well as the simulation of the physics of the vehicle. Customers demand a highly realistic three dimensional forestry landscape and the realistic simulation of the complex motion of the vehicle even in rough terrain in order to be able to use the simulator for operator training under close-to- reality conditions. The realistic simulation of the vehicle, especially with the driver's seat mounted on a motion platform, greatly improves the effect of immersion into the virtual reality of a simulated forest and the achievable level of education of the driver. Thus, the connection of the real control devices of forest machines to the simulation system has to be supported, i.e. the real control devices like the joysticks or the board computer system to control the crane, the aggregate etc. Beyond, the fusion of the board computer system and the simulation system is realized by means of sensors, i.e. digital and analog signals. The decentralized system structure allows several virtual reality systems to evaluate and visualize the information of the control devices and the sensors. So, while the driver is practicing, the instructor can immerse into the same virtual forest to monitor the session from his own viewpoint. In this paper, we are describing the realized structure as well as the necessary software and hardware components and application experiences.

The Terra Data Fusion Project: An Update

NASA Astrophysics Data System (ADS)

Di Girolamo, L.; Bansal, S.; Butler, M.; Fu, D.; Gao, Y.; Lee, H. J.; Liu, Y.; Lo, Y. L.; Raila, D.; Turner, K.; Towns, J.; Wang, S. W.; Yang, K.; Zhao, G.

2017-12-01

Terra is the flagship of NASA's Earth Observing System. Launched in 1999, Terra's five instruments continue to gather data that enable scientists to address fundamental Earth science questions. By design, the strength of the Terra mission has always been rooted in its five instruments and the ability to fuse the instrument data together for obtaining greater quality of information for Earth Science compared to individual instruments alone. As the data volume grows and the central Earth Science questions move towards problems requiring decadal-scale data records, the need for data fusion and the ability for scientists to perform large-scale analytics with long records have never been greater. The challenge is particularly acute for Terra, given its growing volume of data (> 1 petabyte), the storage of different instrument data at different archive centers, the different file formats and projection systems employed for different instrument data, and the inadequate cyberinfrastructure for scientists to access and process whole-mission fusion data (including Level 1 data). Sharing newly derived Terra products with the rest of the world also poses challenges. As such, the Terra Data Fusion Project aims to resolve two long-standing problems: 1) How do we efficiently generate and deliver Terra data fusion products? 2) How do we facilitate the use of Terra data fusion products by the community in generating new products and knowledge through national computing facilities, and disseminate these new products and knowledge through national data sharing services? Here, we will provide an update on significant progress made in addressing these problems by working with NASA and leveraging national facilities managed by the National Center for Supercomputing Applications (NCSA). The problems that we faced in deriving and delivering Terra L1B2 basic, reprojected and cloud-element fusion products, such as data transfer, data fusion, processing on different computer architectures, science, and sharing, will be presented with quantitative specifics. Results from several science-specific drivers for Terra fusion products will also be presented. We demonstrate that the Terra Data Fusion Project itself provides an excellent use-case for the community addressing Big Data and cyberinfrastructure problems.

Effect of driver impedance on dense plasma focus Z-pinch neutron yield

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sears, Jason, E-mail: sears8@llnl.gov, E-mail: schmidt36@llnl.gov; Link, Anthony, E-mail: sears8@llnl.gov, E-mail: schmidt36@llnl.gov; Schmidt, Andrea, E-mail: sears8@llnl.gov, E-mail: schmidt36@llnl.gov

2014-12-15

The Z-pinch phase of a dense plasma focus (DPF) heats the plasma by rapid compression and accelerates ions across its intense electric fields, producing neutrons through both thermonuclear and beam-target fusion. Driver characteristics have empirically been shown to affect performance, as measured by neutron yield per unit of stored energy. We are exploring the effect of driver characteristics on DPF performance using particle-in-cell (PIC) simulations of a kJ scale DPF. In this work, our PIC simulations are fluid for the run-down phase and transition to fully kinetic for the pinch phase, capturing kinetic instabilities, anomalous resistivity, and beam formation duringmore » the pinch. The anode-cathode boundary is driven by a circuit model of the capacitive driver, including system inductance, the load of the railgap switches, the guard resistors, and the coaxial transmission line parameters. It is known that the driver impedance plays an important role in the neutron yield: first, it sets the peak current achieved at pinch time; and second, it affects how much current continues to flow through the pinch when the pinch inductance and resistance suddenly increase. Here we show from fully kinetic simulations how total neutron yield depends on the impedance of the driver and the distributed parameters of the transmission circuit. Direct comparisons between the experiment and simulations enhance our understanding of these plasmas and provide predictive design capability for neutron source applications.« less

Identification of ETV6-RUNX1-like and DUX4-rearranged subtypes in paediatric B-cell precursor acute lymphoblastic leukaemia.

PubMed

Lilljebjörn, Henrik; Henningsson, Rasmus; Hyrenius-Wittsten, Axel; Olsson, Linda; Orsmark-Pietras, Christina; von Palffy, Sofia; Askmyr, Maria; Rissler, Marianne; Schrappe, Martin; Cario, Gunnar; Castor, Anders; Pronk, Cornelis J H; Behrendtz, Mikael; Mitelman, Felix; Johansson, Bertil; Paulsson, Kajsa; Andersson, Anna K; Fontes, Magnus; Fioretos, Thoas

2016-06-06

Fusion genes are potent driver mutations in cancer. In this study, we delineate the fusion gene landscape in a consecutive series of 195 paediatric B-cell precursor acute lymphoblastic leukaemia (BCP ALL). Using RNA sequencing, we find in-frame fusion genes in 127 (65%) cases, including 27 novel fusions. We describe a subtype characterized by recurrent IGH-DUX4 or ERG-DUX4 fusions, representing 4% of cases, leading to overexpression of DUX4 and frequently co-occurring with intragenic ERG deletions. Furthermore, we identify a subtype characterized by an ETV6-RUNX1-like gene-expression profile and coexisting ETV6 and IKZF1 alterations. Thus, this study provides a detailed overview of fusion genes in paediatric BCP ALL and adds new pathogenetic insights, which may improve risk stratification and provide therapeutic options for this disease.

A cryptic translocation leading to NUP98-PHF23 fusion in AML.

PubMed

Ning, Yi

2016-12-01

Chromosome translocations leading to gene fusions have emerged as important oncogenic drivers of various types of malignancies. Detection and characterization of these fusion genes not only help diagnosis and management of specific malignancies, but also contribute to our understanding of the genetic basis and pathogenesis of these diseases. NUP98 gene encodes a 98 kDa nucleoporin, which is a component of the nuclear pore complex that mediates transport of mRNA and proteins between the nucleus and the cytoplasm. Due to its participation in translocations leading to the formation of fusion with at least 29 different partner genes, NUP98 is considered one of the most promiscuous fusion genes in hematologic malignancies. We discuss our identification and characterization of a NUP98-PHF23 fusion from a cryptic translocation in patients with acute myeloid leukemia (AML). Copyright © 2016 Elsevier Ltd. All rights reserved.

Modeling and numerical analysis of a magneto-inertial fusion concept with the target created through FRC merging

NASA Astrophysics Data System (ADS)

Li, Chenguang; Yang, Xianjun

2016-10-01

The Magnetized Plasma Fusion Reactor concept is proposed as a magneto-inertial fusion approach based on the target plasma created through the collision merging of two oppositely translating field reversed configuration plasmas, which is then compressed by the imploding liner driven by the pulsed-power driver. The target creation process is described by a two-dimensional magnetohydrodynamics model, resulting in the typical target parameters. The implosion process and the fusion reaction are modeled by a simple zero-dimensional model, taking into account the alpha particle heating and the bremsstrahlung radiation loss. The compression on the target can be 2D cylindrical or 2.4D with the additive axial contraction taken into account. The dynamics of the liner compression and fusion burning are simulated and the optimum fusion gain and the associated target parameters are predicted. The scientific breakeven could be achieved at the optimized conditions.

Upregulation of PD-L1 by EML4-ALK fusion protein mediates the immune escape in ALK positive NSCLC: Implication for optional anti-PD-1/PD-L1 immune therapy for ALK-TKIs sensitive and resistant NSCLC patients.

PubMed

Hong, Shaodong; Chen, Nan; Fang, Wenfeng; Zhan, Jianhua; Liu, Qing; Kang, Shiyang; He, Xiaobo; Liu, Lin; Zhou, Ting; Huang, Jiaxing; Chen, Ying; Qin, Tao; Zhang, Yaxiong; Ma, Yuxiang; Yang, Yunpeng; Zhao, Yuanyuan; Huang, Yan; Zhang, Li

2016-03-01

Driver mutations were reported to upregulate programmed death-ligand 1 (PD-L1) expression. However, how PD-L1 expression and immune function was affected by ALK-TKIs and anti-PD-1/PD-L1 treatment in ALK positive non-small-cell lung cancer (NSCLC) remains poorly understood. In the present study, western-blot, real-time PCR, flow cytometry and immunofluorescence were employed to explore how PD-L1 was regulated by ALK fusion protein. ALK-TKIs and relevant inhibitors were used to identify the downstream signaling pathways involved in PD-L1 regulation. Cell apoptosis, viability and Elisa test were used to study the immune suppression by ALK activation and immune reactivation by ALK-TKIs and/or PD-1 blocking in tumor cells and DC-CIK cells co-culture system. We found that PD-L1 expression was associated with EGFR mutations and ALK fusion genes in NSCLC cell lines. Over-expression of ALK fusion protein increased PD-L1 expression. PD-L1 mediated by ALK fusion protein increased the apoptosis of T cells in tumor cells and DC-CIK cells co-culture system. Inhibiting ALK by sensitive TKIs could enhance the production of IFNγ. Anti-PD-1 antibody was effective in both crizotinib sensitive and resistant NSCLC cells. Synergistic tumor killing effects were not observed with ALK-TKIs and anti-PD-1 antibody combination in co-culture system. ALK-TKIs not only directly inhibited tumor viability but also indirectly enhanced the antitumor immunity via the downregulation of PD-L1. Anti-PD-1/PD-L1 antibodies could be an optional therapy for crizotinib sensitive, especially crizotinib resistant NSCLC patients with ALK fusion gene. Combination of ALK-TKIs and anti-PD-1/PD-L1 antibodies treatment for ALK positive NSCLC warrants more data before moving into clinical practice.

Upregulation of PD-L1 by EML4-ALK fusion protein mediates the immune escape in ALK positive NSCLC: Implication for optional anti-PD-1/PD-L1 immune therapy for ALK-TKIs sensitive and resistant NSCLC patients

PubMed Central

Hong, Shaodong; Chen, Nan; Fang, Wenfeng; Zhan, Jianhua; Liu, Qing; Kang, Shiyang; He, Xiaobo; Liu, Lin; Zhou, Ting; Huang, Jiaxing; Chen, Ying; Qin, Tao; Zhang, Yaxiong; Ma, Yuxiang; Yang, Yunpeng; Zhao, Yuanyuan; Huang, Yan; Zhang, Li

2016-01-01

ABSTRACT Driver mutations were reported to upregulate programmed death-ligand 1 (PD-L1) expression. However, how PD-L1 expression and immune function was affected by ALK-TKIs and anti-PD-1/PD-L1 treatment in ALK positive non-small-cell lung cancer (NSCLC) remains poorly understood. In the present study, western-blot, real-time PCR, flow cytometry and immunofluorescence were employed to explore how PD-L1 was regulated by ALK fusion protein. ALK-TKIs and relevant inhibitors were used to identify the downstream signaling pathways involved in PD-L1 regulation. Cell apoptosis, viability and Elisa test were used to study the immune suppression by ALK activation and immune reactivation by ALK-TKIs and/or PD-1 blocking in tumor cells and DC-CIK cells co-culture system. We found that PD-L1 expression was associated with EGFR mutations and ALK fusion genes in NSCLC cell lines. Over-expression of ALK fusion protein increased PD-L1 expression. PD-L1 mediated by ALK fusion protein increased the apoptosis of T cells in tumor cells and DC-CIK cells co-culture system. Inhibiting ALK by sensitive TKIs could enhance the production of IFNγ. Anti-PD-1 antibody was effective in both crizotinib sensitive and resistant NSCLC cells. Synergistic tumor killing effects were not observed with ALK-TKIs and anti-PD-1 antibody combination in co-culture system. ALK-TKIs not only directly inhibited tumor viability but also indirectly enhanced the antitumor immunity via the downregulation of PD-L1. Anti-PD-1/PD-L1 antibodies could be an optional therapy for crizotinib sensitive, especially crizotinib resistant NSCLC patients with ALK fusion gene. Combination of ALK-TKIs and anti-PD-1/PD-L1 antibodies treatment for ALK positive NSCLC warrants more data before moving into clinical practice. PMID:27141355

Magnetized Target Fusion Driven by Plasma Liners

NASA Technical Reports Server (NTRS)

Thio, Y. C. Francis; Cassibry, Jason; Eskridge, Richard; Kirkpatrick, Ronald C.; Knapp, Charles E.; Lee, Michael; Martin, Adam; Smith, James; Wu, S. T.; Rodgers, Stephen L. (Technical Monitor)

2001-01-01

For practical applications of magnetized target fusion, standoff drivers to deliver the imploding momentum flux to the target plasma remotely are required. Quasi-spherically converging plasma jets have been proposed as standoff drivers for this purpose. The concept involves the dynamic formation of a quasi-spherical plasma liner by the merging of plasma jets, and the use of the liner so formed to compress a spheromak or a field reversed configuration (FRC). Theoretical analysis and computer modeling of the concept are presented. It is shown that, with the appropriate choice of the flow parameters in the liner and the target, the impact between the liner and the target plasma can be made to be shockless in the liner or to generate at most a very weak shock in the liner. Additional information is contained in the original extended abstract.

Plasma-wall interaction in laser inertial fusion reactors: novel proposals for radiation tests of first wall materials

NASA Astrophysics Data System (ADS)

Alvarez Ruiz, J.; Rivera, A.; Mima, K.; Garoz, D.; Gonzalez-Arrabal, R.; Gordillo, N.; Fuchs, J.; Tanaka, K.; Fernández, I.; Briones, F.; Perlado, J.

2012-12-01

Dry-wall laser inertial fusion (LIF) chambers will have to withstand strong bursts of fast charged particles which will deposit tens of kJ m-2 and implant more than 1018 particles m-2 in a few microseconds at a repetition rate of some Hz. Large chamber dimensions and resistant plasma-facing materials must be combined to guarantee the chamber performance as long as possible under the expected threats: heating, fatigue, cracking, formation of defects, retention of light species, swelling and erosion. Current and novel radiation resistant materials for the first wall need to be validated under realistic conditions. However, at present there is a lack of facilities which can reproduce such ion environments. This contribution proposes the use of ultra-intense lasers and high-intense pulsed ion beams (HIPIB) to recreate the plasma conditions in LIF reactors. By target normal sheath acceleration, ultra-intense lasers can generate very short and energetic ion pulses with a spectral distribution similar to that of the inertial fusion ion bursts, suitable to validate fusion materials and to investigate the barely known propagation of those bursts through background plasmas/gases present in the reactor chamber. HIPIB technologies, initially developed for inertial fusion driver systems, provide huge intensity pulses which meet the irradiation conditions expected in the first wall of LIF chambers and thus can be used for the validation of materials too.

Raman accumulator as a fusion laser driver

DOEpatents

George, E. Victor; Swingle, James C.

1985-01-01

Apparatus for simultaneous laser pulse amplification and compression, using multiple pass Raman scattering in one Raman cell and pulse switchout from the optical cavity through use of a dichroic device associated with the Raman cell.

Raman accumulator as a fusion laser driver

DOEpatents

George, E.V.; Swingle, J.C.

1982-03-31

Apparatus for simultaneous laser pulse amplification and compression, using multiple pass Raman scattering in one Raman cell and pulse switchout from the optical cavity through use of a dichroic device associated with the Raman cell.

Multimodality Inferring of Human Cognitive States Based on Integration of Neuro-Fuzzy Network and Information Fusion Techniques

NASA Astrophysics Data System (ADS)

Yang, G.; Lin, Y.; Bhattacharya, P.

2007-12-01

To achieve an effective and safe operation on the machine system where the human interacts with the machine mutually, there is a need for the machine to understand the human state, especially cognitive state, when the human's operation task demands an intensive cognitive activity. Due to a well-known fact with the human being, a highly uncertain cognitive state and behavior as well as expressions or cues, the recent trend to infer the human state is to consider multimodality features of the human operator. In this paper, we present a method for multimodality inferring of human cognitive states by integrating neuro-fuzzy network and information fusion techniques. To demonstrate the effectiveness of this method, we take the driver fatigue detection as an example. The proposed method has, in particular, the following new features. First, human expressions are classified into four categories: (i) casual or contextual feature, (ii) contact feature, (iii) contactless feature, and (iv) performance feature. Second, the fuzzy neural network technique, in particular Takagi-Sugeno-Kang (TSK) model, is employed to cope with uncertain behaviors. Third, the sensor fusion technique, in particular ordered weighted aggregation (OWA), is integrated with the TSK model in such a way that cues are taken as inputs to the TSK model, and then the outputs of the TSK are fused by the OWA which gives outputs corresponding to particular cognitive states under interest (e.g., fatigue). We call this method TSK-OWA. Validation of the TSK-OWA, performed in the Northeastern University vehicle drive simulator, has shown that the proposed method is promising to be a general tool for human cognitive state inferring and a special tool for the driver fatigue detection.

Development of Field-Reversed Configuration Plasma Gun Formation Techniques for Magnetized Target Fusion

NASA Astrophysics Data System (ADS)

Lynn, Alan; Gilmore, Mark; Wynkoop, Tyler; Intrator, Thomas; Weber, Thomas

2012-10-01

Magnetized Target Fusion (MTF) is an innovative approach for a relatively fast and cheap path to the production of fusion energy that utilizes magnetic confinement to assist in the compression of a hot plasma to thermonuclear conditions by an external driver. Los Alamos National Laboratory (LANL) is currently pursing demonstration of the MTF concept via compression of an FRC (field-reversed configuration) plasma by a metal liner z-pinch in conjunction with the Air Force Research Laboratory in Albuquerque, NM. A key physics issue for the FRC as an MTF target lies in the initial pre-ionization (PI) stage. The PI formation process determines the amount of magnetic flux that can be trapped to form the FRC. This trapped flux plays an important role in the FRC's final equilibrium, transport, and stability properties. It also provides the route to greatest potential gains in FRC lifetime, which is essential to provide enough time to translate and compress the FRC effectively. In conjunction with LANL we plan to test and characterize a new system to improve the initial PI plasma formation. This system will use an array of plasma guns to form the initial plasma. Initial characterization of the plasma gun behavior will be presented.

Genomic analysis of fibrolamellar hepatocellular carcinoma.

PubMed

Xu, Lei; Hazard, Florette K; Zmoos, Anne-Flore; Jahchan, Nadine; Chaib, Hassan; Garfin, Phillip M; Rangaswami, Arun; Snyder, Michael P; Sage, Julien

2015-01-01

Pediatric tumors are relatively infrequent, but are often associated with significant lethality and lifelong morbidity. A major goal of pediatric cancer research has been to identify key drivers of tumorigenesis to eventually develop targeted therapies to enhance cure rate and minimize acute and long-term toxic effects. Here, we used genomic approaches to identify biomarkers and candidate drivers for fibrolamellar hepatocellular carcinoma (FL-HCC), a very rare subtype of pediatric liver cancer for which limited therapeutic options exist. In-depth genomic analyses of one tumor followed by immunohistochemistry validation on seven other tumors showed expression of neuroendocrine markers in FL-HCC. DNA and RNA sequencing data further showed that common cancer pathways are not visibly altered in FL-HCC but identified two novel structural variants, both resulting in fusion transcripts. The first, a 400 kb deletion, results in a DNAJB1-PRKCA fusion transcript, which leads to increased cAMP-dependent protein kinase (PKA) activity in the index tumor case and other FL-HCC cases compared with normal liver. This PKA fusion protein is oncogenic in HCC cells. The second gene fusion event, a translocation between the CLPTM1L and GLIS3 genes, generates a transcript whose product also promotes cancer phenotypes in HCC cell lines. These experiments further highlight the tumorigenic role of gene fusions in the etiology of pediatric solid tumors and identify both candidate biomarkers and possible therapeutic targets for this lethal pediatric disease. © The Author 2014. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Lung cancer in never-smoker Asian females is driven by oncogenic mutations, most often involving EGFR

PubMed Central

Choi, Hye Joo; Lee, Jinseon; Jung, Kyungsoo; Irwin, Darry; Liu, Xiao; Lira, Maruja E.; Mao, Mao; Kim, Hong Kwan; Choi, Yong Soo; Shim, Young Mog; Park, Woong Yang; Choi, Yoon-La; Kim, Jhingook

2015-01-01

The aim of this study was to determine the distribution of known oncogenic driver mutations in female never-smoker Asian patients with lung adenocarcinoma. We analyzed 214 mutations across 26 lung cancer-associated genes and three fusion genes using the MassARRAY® LungCarta Panel and the ALK, ROS1, and RET fusion assays in 198 consecutively resected lung adenocarcinomas from never-smoker females at a single institution. EGFR mutation, which was the most frequent driver gene mutation, was detected in 124 (63%) cases. Mutation of ALK, KRAS, PIK3CA, ERBB2, BRAF, ROS1, and RET genesoccurred in 7%, 4%, 2.5%, 1.5%, 1%, 1%, and 1% of cases, respectively. Thus, 79% of lung adenocarcinomas from never-smoker females harbored well-known oncogenic mutations. Mucinous adenocarcinomas tended to have a lower frequency of known driver gene mutations than other histologic subtypes. EGFR mutation was associated with older age and a predominantly acinar pattern, while ALK rearrangement was associated with younger age and a predominantly solid pattern. Lung cancer in never-smoker Asian females is a distinct entity, with the majority of these cancers developing from oncogenic mutations. PMID:25760072

High-energy krypton fluoride lasers for inertial fusion.

PubMed

Obenschain, Stephen; Lehmberg, Robert; Kehne, David; Hegeler, Frank; Wolford, Matthew; Sethian, John; Weaver, James; Karasik, Max

2015-11-01

Laser fusion researchers have realized since the 1970s that the deep UV light from excimer lasers would be an advantage as a driver for robust high-performance capsule implosions for inertial confinement fusion (ICF). Most of this research has centered on the krypton-fluoride (KrF) laser. In this article we review the advantages of the KrF laser for direct-drive ICF, the history of high-energy KrF laser development, and the present state of the art and describe a development path to the performance needed for laser fusion and its energy application. We include descriptions of the architecture and performance of the multi-kilojoule Nike KrF laser-target facility and the 700 J Electra high-repetition-rate KrF laser that were developed at the U.S. Naval Research Laboratory. Nike and Electra are the most advanced KrF lasers for inertial fusion research and energy applications.

Plasma-Jet Magneto-Inertial Fusion Burn Calculations

NASA Astrophysics Data System (ADS)

Santarius, John

2010-11-01

Several issues exist related to using plasma jets to implode a Magneto-Inertial Fusion (MIF) liner onto a magnetized plasmoid and compress it to fusion-relevant temperatures [1]. The poster will explore how well the liner's inertia provides transient plasma confinement and affects the burn dynamics. The investigation uses the University of Wisconsin's 1-D Lagrangian radiation-hydrodynamics code, BUCKY, which solves single-fluid equations of motion with ion-electron interactions, PdV work, table-lookup equations of state, fast-ion energy deposition, pressure contributions from all species, and one or two temperatures. Extensions to the code include magnetic field evolution as the plasmoid compresses plus dependence of the thermal conductivity on the magnetic field. [4pt] [1] Y.C. F. Thio, et al.,``Magnetized Target Fusion in a Spheroidal Geometry with Standoff Drivers,'' in Current Trends in International Fusion Research, E. Panarella, ed. (National Research Council of Canada, Ottawa, Canada, 1999), p. 113.

On the path to fusion energy

NASA Astrophysics Data System (ADS)

Tabak, M.

2016-10-01

There is a need to develop alternate energy sources in the coming century because fossil fuels will become depleted and their use may lead to global climate change. Inertial fusion can become such an energy source, but significant progress must be made before its promise is realized. The high-density approach to inertial fusion suggested by Nuckolls et al. leads reaction chambers compatible with civilian power production. Methods to achieve the good control of hydrodynamic stability and implosion symmetry required to achieve these high fuel densities will be discussed. Fast Ignition, a technique that achieves fusion ignition by igniting fusion fuel after it is assembled, will be described along with its gain curves. Fusion costs of energy for conventional hotspot ignition will be compared with those of Fast Ignition and their capital costs compared with advanced fission plants. Finally, techniques that may improve possible Fast Ignition gains by an order of magnitude and reduce driver scales by an order of magnitude below conventional ignition requirements are described.

Phase I/II study of alectinib in lung cancer with RET fusion gene: study protocol.

PubMed

Takeuchi, Shinji; Murayama, Toshinori; Yoshimura, Kenichi; Kawakami, Takahiro; Takahara, Shizuko; Imai, Yasuhito; Kuribayashi, Yoshikazu; Nagase, Katsuhiko; Goto, Koichi; Nishio, Makoto; Hasegawa, Yoshinori; Satouchi, Miyako; Kiura, Katsuyuki; Seto, Takashi; Yano, Seiji

2017-01-01

The rearranged during transfection (RET) fusion gene was discovered as a driver oncogene in 1-2% of non-small cell lung cancers (NSCLCs). Alectinib is an approved anaplastic lymphoma kinase (ALK) inhibitor that may also be effective for RET fusion-positive NSCLC. RET fusion-positive NSCLC patients treated with at least one regimen of chemotherapy are being recruited. In step 1, alectinib (600 or 450 mg, twice daily) will be administered following a 3+3 design. The primary endpoint is safety. In step 2, alectinib will be administered at the recommended dose (RD) defined by step 1. The primary endpoint is the response rate of RET inhibitor treatment-naïve patients. This is the first study to investigate the safety and preliminary efficacy of alectinib in RET fusion-positive NSCLC patients. If successful, alectinib treatment may lead to substantial and important changes in the management of NSCLC with RET fusion genes. J. Med. Invest. 64: 317-320, August, 2017.

One-Dimensional Burn Dynamics of Plasma-Jet Magneto-Inertial Fusion

NASA Astrophysics Data System (ADS)

Santarius, John

2009-11-01

This poster will discuss several issues related to using plasma jets to implode a Magneto-Inertial Fusion (MIF) liner onto a magnetized plasmoid and compress it to fusion-relevant temperatures [1]. The problem of pure plasma jet convergence and compression without a target present will be investigated. Cases with a target present will explore how well the liner's inertia provides transient plasma stability and confinement. The investigation uses UW's 1-D Lagrangian radiation-hydrodynamics code, BUCKY, which solves single-fluid equations of motion with ion-electron interactions, PdV work, table-lookup equations of state, fast-ion energy deposition, and pressure contributions from all species. Extensions to the code include magnetic field evolution as the plasmoid compresses plus dependence of the thermal conductivity and fusion product energy deposition on the magnetic field.[4pt] [1] Y.C. F. Thio, et al.,``Magnetized Target Fusion in a Spheroidal Geometry with Standoff Drivers,'' in Current Trends in International Fusion Research, E. Panarella, ed. (National Research Council of Canada, Ottawa, Canada, 1999), p. 113.

Digital Controller For Acoustic Levitation

NASA Technical Reports Server (NTRS)

Tarver, D. Kent

1989-01-01

Acoustic driver digitally controls sound fields along three axes. Allows computerized acoustic levitation and manipulation of small objects for such purposes as containerless processing and nuclear-fusion power experiments. Also used for controlling motion of vibration-testing tables in three dimensions.

Driver development of IFE power plant in Japan Collaborative process with industry and industrial applications

NASA Astrophysics Data System (ADS)

Nakai, S.; Yamanaka, M.; Kitagawa, Y.; Fujita, K.; Heya, M.; Mima, K.; Izawa, Y.; Nakatsuka, M.; Murakami, M.; Ueda, K.; Sasaki, T.; Mori, Y.; Kanabe, T.; Hiruma, T.; Kan, H.; Kawashima, T.

2006-06-01

The typical specifications of the laser driver for a commercial IFE power plant are (1) total energy (MJ/pulse) with a tailored 20-40 ns pulse, (2) repetition operation (˜ 10 Hz), (3) efficiency (˜ 10%) with enough robustness and low cost. The key elements of the DPSSL driver technology are under development with HALNA. The HALNA 10 (High Average-power Laser for Nuclear-fusion Application) demonstrated 10 J × 10 Hz operation and the HALNA 100 (100 J × 10 Hz) is now under construction. By using the high average power and high intensity lasers, new industrial applications are being proceeded. The collaborative process for the development of high power laser with industry and for the industrial applications is effective and essential in the development of the laser driver for IFE power plant.

Overview of theory and simulations in the Heavy Ion Fusion Science Virtual National Laboratory

NASA Astrophysics Data System (ADS)

Friedman, Alex

2007-07-01

The Heavy Ion Fusion Science Virtual National Laboratory (HIFS-VNL) is a collaboration of Lawrence Berkeley National Laboratory, Lawrence Livermore National Laboratory, and Princeton Plasma Physics Laboratory. These laboratories, in cooperation with researchers at other institutions, are carrying out a coordinated effort to apply intense ion beams as drivers for studies of the physics of matter at extreme conditions, and ultimately for inertial fusion energy. Progress on this endeavor depends upon coordinated application of experiments, theory, and simulations. This paper describes the state of the art, with an emphasis on the coordination of modeling and experiment; developments in the simulation tools, and in the methods that underly them, are also treated.

An RFID-based intelligent vehicle speed controller using active traffic signals.

PubMed

Pérez, Joshué; Seco, Fernando; Milanés, Vicente; Jiménez, Antonio; Díaz, Julio C; de Pedro, Teresa

2010-01-01

These days, mass-produced vehicles benefit from research on Intelligent Transportation System (ITS). One prime example of ITS is vehicle Cruise Control (CC), which allows it to maintain a pre-defined reference speed, to economize on fuel or energy consumption, to avoid speeding fines, or to focus all of the driver's attention on the steering of the vehicle. However, achieving efficient Cruise Control is not easy in roads or urban streets where sudden changes of the speed limit can happen, due to the presence of unexpected obstacles or maintenance work, causing, in inattentive drivers, traffic accidents. In this communication we present a new Infrastructure to Vehicles (I2V) communication and control system for intelligent speed control, which is based upon Radio Frequency Identification (RFID) technology for identification of traffic signals on the road, and high accuracy vehicle speed measurement with a Hall effect-based sensor. A fuzzy logic controller, based on sensor fusion of the information provided by the I2V infrastructure, allows the efficient adaptation of the speed of the vehicle to the circumstances of the road. The performance of the system is checked empirically, with promising results.

Sensor fusion to enable next generation low cost Night Vision systems

NASA Astrophysics Data System (ADS)

Schweiger, R.; Franz, S.; Löhlein, O.; Ritter, W.; Källhammer, J.-E.; Franks, J.; Krekels, T.

2010-04-01

The next generation of automotive Night Vision Enhancement systems offers automatic pedestrian recognition with a performance beyond current Night Vision systems at a lower cost. This will allow high market penetration, covering the luxury as well as compact car segments. Improved performance can be achieved by fusing a Far Infrared (FIR) sensor with a Near Infrared (NIR) sensor. However, fusing with today's FIR systems will be too costly to get a high market penetration. The main cost drivers of the FIR system are its resolution and its sensitivity. Sensor cost is largely determined by sensor die size. Fewer and smaller pixels will reduce die size but also resolution and sensitivity. Sensitivity limits are mainly determined by inclement weather performance. Sensitivity requirements should be matched to the possibilities of low cost FIR optics, especially implications of molding of highly complex optical surfaces. As a FIR sensor specified for fusion can have lower resolution as well as lower sensitivity, fusing FIR and NIR can solve performance and cost problems. To allow compensation of FIR-sensor degradation on the pedestrian detection capabilities, a fusion approach called MultiSensorBoosting is presented that produces a classifier holding highly discriminative sub-pixel features from both sensors at once. The algorithm is applied on data with different resolution and on data obtained from cameras with varying optics to incorporate various sensor sensitivities. As it is not feasible to record representative data with all different sensor configurations, transformation routines on existing high resolution data recorded with high sensitivity cameras are investigated in order to determine the effects of lower resolution and lower sensitivity to the overall detection performance. This paper also gives an overview of the first results showing that a reduction of FIR sensor resolution can be compensated using fusion techniques and a reduction of sensitivity can be compensated.

Laser-guided, intersecting discharge channels for the final beam transport in heavy-ion fusion

NASA Astrophysics Data System (ADS)

Niemann, C.; Neff, S.; Tauschwitz, A.; Penache, D.; Birkner, R.; Constantin, C.; Knobloch, R.; Presura, R.; Rosmej, F. B.; Hoffmann, D. H. H.; Yu, S. S.

2003-06-01

Ion-beam transport in space charge neutralizing discharge channels has been proposed for the final focus and chamber transport in a heavy-ion fusion reactor. A driver scenario with two-sided target illumination requires a system of two intersecting discharges to transport beams of the same charge from opposite sides towards the fusion target. In this article we report on experiments on the creation of free-standing, intersecting high-current discharge channels. The discharges are initiated in ammonia gas (NH3) in a metallic chamber by two perpendicular CO2-laser beams, which resonantly heat and subsequently rarefy the gas along the laser paths before the breakdown. These low density channels guide the discharges along the predefined paths and also around the 90° angles without any mechanical guiding structures. In this way stable X-, T-, and L-shaped discharges with currents in excess of 40 kA, at pressures of a few mbar were created with a total length of 110 cm. An 11.4 A MeV 58Ni+12 beam from the UNILAC (Universal Linear Accelerator) linear accelerator was used to probe the line-integrated ion-optical properties of the central channel in a T-shaped discharge.

Thermal management in inertial fusion energy slab amplifiers

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sutton, S.B.; Albrecht, G.F.

As the technology associated with the development of solid-state drivers for inertial fusion energy (IFE) has evolved, increased emphasis has been placed on the development of an efficient approach for managing the waste heat generated in the laser media. This paper addresses the technical issues associated with the gas cooling of large aperture slabs, where the laser beam propagates through the cooling fluid. It is shown that the major consequence of proper thermal management is the introduction of simple wedge, or beam steering, into the system. Achieving proper thermal management requires careful consideration of the geometry, cooling fluid characteristics, coolingmore » flow characteristics, as well as the thermal/mechanical/optical characteristics of the laser media. Particularly important are the effects of cooling rate variation and turbulent scattering on the system optical performance. Helium is shown to have an overwhelming advantage with respect to turbulent scattering losses. To mitigate cooling rate variations, the authors introduce the concept of flow conditioning. Finally, optical path length variations across the aperture are calculated. A comparison of two laser materials (S-FAP and YAG) shows the benefit of a nearly a-thermal material on optical variations in the system.« less

RSPO3 expands intestinal stem cell and niche compartments and drives tumorigenesis

PubMed Central

Hilkens, John; Timmer, Nikki C; Boer, Mandy; Ikink, Gerjon J; Schewe, Matthias; Sacchetti, Andrea; Koppens, Martijn A J; Song, Ji-Ying; Bakker, Elvira R M

2017-01-01

Objective The gross majority of colorectal cancer cases results from aberrant Wnt/β-catenin signalling through adenomatous polyposis coli (APC) or CTNNB1 mutations. However, a subset of human colon tumours harbour, mutually exclusive with APC and CTNNB1 mutations, gene fusions in RSPO2 or RSPO3, leading to enhanced expression of these R-spondin genes. This suggested that RSPO activation can substitute for the most common mutations as an alternative driver for intestinal cancer. Involvement of RSPO3 in tumour growth was recently shown in RSPO3-fusion-positive xenograft models. The current study determines the extent into which solely a gain in RSPO3 actually functions as a driver of intestinal cancer in a direct, causal fashion, and addresses the in vivo activities of RSPO3 in parallel. Design We generated a conditional Rspo3 transgenic mouse model in which the Rspo3 transgene is expressed upon Cre activity. Cre is provided by cross-breeding with Lgr5-GFP-CreERT2 mice. Results Upon in vivo Rspo3 expression, mice rapidly developed extensive hyperplastic, adenomatous and adenocarcinomatous lesions throughout the intestine. RSPO3 induced the expansion of Lgr5+ stem cells, Paneth cells, non-Paneth cell label-retaining cells and Lgr4+ cells, thus promoting both intestinal stem cell and niche compartments. Wnt/β-catenin signalling was modestly increased upon Rspo3 expression and mutant Kras synergised with Rspo3 in hyperplastic growth. Conclusions We provide in vivo evidence that RSPO3 stimulates the crypt stem cell and niche compartments and drives rapid intestinal tumorigenesis. This establishes RSPO3 as a potent driver of intestinal cancer and proposes RSPO3 as a candidate target for therapy in patients with colorectal cancer harbouring RSPO3 fusions. PMID:27511199

Spectrum of oncogenic driver mutations in lung adenocarcinomas from East Asian never smokers.

PubMed

Li, Chenguang; Fang, Rong; Sun, Yihua; Han, Xiangkun; Li, Fei; Gao, Bin; Iafrate, A John; Liu, Xin-Yuan; Pao, William; Chen, Haiquan; Ji, Hongbin

2011-01-01

We previously showed that 90% (47 of 52; 95% CI, 0.79 to 0.96) of lung adenocarcinomas from East Asian never-smokers harbored well-known oncogenic mutations in just four genes: EGFR, HER2, ALK, and KRAS. Here, we sought to extend these findings to more samples and identify driver alterations in tumors negative for these mutations. We have collected and analyzed 202 resected lung adenocarcinomas from never smokers seen at Fudan University Shanghai Cancer Center. Since mutations were mutually exclusive in the first 52 examined, we determined the status of EGFR, KRAS, HER2, ALK, and BRAF in stepwise fashion as previously described. Samples negative for mutations in these 5 genes were subsequently examined for known ROS1 fusions by RT-PCR and direct sequencing. 152 tumors (75.3%) harbored EGFR mutations, 12 (6%) had HER2 mutations, 10 (5%) had ALK fusions all involving EML4 as the 5' partner, 4 (2%) had KRAS mutations, and 2 (1%) harbored ROS1 fusions. No BRAF mutation were detected. The vast majority (176 of 202; 87.1%, 95% CI: 0.82 to 0.91) of lung adenocarcinomas from never smokers harbor mutant kinases sensitive to available TKIs. Interestingly, patients with EGFR mutant patients tend to be older than those without EGFR mutations (58.3 Vs 54.3, P = 0.016) and patient without any known oncogenic driver tend to be diagnosed at a younger age (52.3 Vs 57.9, P = 0.013). Collectively, these data indicate that the majority of never smokers with lung adenocarcinoma could benefit from treatment with a specific tyrosine kinase inhibitor.

Spectrum of Oncogenic Driver Mutations in Lung Adenocarcinomas from East Asian Never Smokers

PubMed Central

Han, Xiangkun; Li, Fei; Gao, Bin; Iafrate, A. John; Liu, Xin-Yuan; Pao, William; Chen, Haiquan; Ji, Hongbin

2011-01-01

Purpose We previously showed that 90% (47 of 52; 95% CI, 0.79 to 0.96) of lung adenocarcinomas from East Asian never-smokers harbored well-known oncogenic mutations in just four genes: EGFR, HER2, ALK, and KRAS. Here, we sought to extend these findings to more samples and identify driver alterations in tumors negative for these mutations. Experimental Design We have collected and analyzed 202 resected lung adenocarcinomas from never smokers seen at Fudan University Shanghai Cancer Center. Since mutations were mutually exclusive in the first 52 examined, we determined the status of EGFR, KRAS, HER2, ALK, and BRAF in stepwise fashion as previously described. Samples negative for mutations in these 5 genes were subsequently examined for known ROS1 fusions by RT-PCR and direct sequencing. Results 152 tumors (75.3%) harbored EGFR mutations, 12 (6%) had HER2 mutations, 10 (5%) had ALK fusions all involving EML4 as the 5′ partner, 4 (2%) had KRAS mutations, and 2 (1%) harbored ROS1 fusions. No BRAF mutation were detected. Conclusion The vast majority (176 of 202; 87.1%, 95% CI: 0.82 to 0.91) of lung adenocarcinomas from never smokers harbor mutant kinases sensitive to available TKIs. Interestingly, patients with EGFR mutant patients tend to be older than those without EGFR mutations (58.3 Vs 54.3, P = 0.016) and patient without any known oncogenic driver tend to be diagnosed at a younger age (52.3 Vs 57.9, P = 0.013). Collectively, these data indicate that the majority of never smokers with lung adenocarcinoma could benefit from treatment with a specific tyrosine kinase inhibitor. PMID:22140546

Altered molecular profile in thyroid cancers from patients affected by the Three Mile Island nuclear accident.

PubMed

Goldenberg, David; Russo, Mariano; Houser, Kenneth; Crist, Henry; Derr, Jonathan B; Walter, Vonn; Warrick, Joshua I; Sheldon, Kathryn E; Broach, James; Bann, Darrin V

2017-07-01

In 1979, Three Mile Island (TMI) nuclear power plant experienced a partial meltdown with release of radioactive material. The effects of the accident on thyroid cancer (TC) in the surrounding population remain unclear. Radiation-induced TCs have a lower incidence of single nucleotide oncogenic driver mutations and higher incidence of gene fusions. We used next generation sequencing (NGS) to identify molecular signatures of radiation-induced TC in a cohort of TC patients residing near TMI during the time of the accident. Case series. We identified 44 patients who developed papillary thyroid carcinoma between 1974 and 2014. Patients who developed TC between 1984 and 1996 were at risk for radiation-induced TC, patients who developed TC before 1984 or after 1996 were the control group. We used targeted NGS of paired tumor and normal tissue from each patient to identify single nucleotide oncogenic driver mutations. Oncogenic gene fusions were identified using quantitative reverse transcription polymerase chain reaction. We identified 15 patients in the at-risk group and 29 patients in the control group. BRAF V600E mutations were identified in 53% patients in the at-risk group and 83% patients in the control group. The proportion of patients with BRAF mutations in the at-risk group was significantly lower than predicted by the The Cancer Genome Atlas cohort. Gene fusion or somatic copy number alteration drivers were identified in 33% tumors in the at-risk group and 14% of tumors in the control group. Findings were consistent with observations from other radiation-exposed populations. These data raise the possibility that radiation released from TMI may have altered the molecular profile of TC in the population surrounding TMI. 4 Laryngoscope, 127:S1-S9, 2017. © 2017 The American Laryngological, Rhinological and Otological Society, Inc.

Design of 3x3 Focusing Array for Heavy Ion Driver Final Report on CRADA TC-02082-04

DOE Office of Scientific and Technical Information (OSTI.GOV)

Martovetsky, N.

This memo presents a design of a 3x3 quadrupole array for HIF. It contains 3 D magnetic field computations of the array build with racetrack coils with and without different shields. It is shown that it is possible to have a low error magnetic field in the cells and shield the stray fields to acceptable levels. The array design seems to be a practical solution to any size array for future multi-beam heavy ion fusion drivers.

Issues and opportunities: beam simulations for heavy ion fusion

DOE Office of Scientific and Technical Information (OSTI.GOV)

Friedman, A

1999-07-15

UCRL- JC- 134975 PREPRINT code offering 3- D, axisymmetric, and ''transverse slice'' (steady flow) geometries, with a hierarchy of models for the ''lattice'' of focusing, bending, and accelerating elements. Interactive and script- driven code steering is afforded through an interpreter interface. The code runs with good parallel scaling on the T3E. Detailed simulations of machine segments and of complete small experiments, as well as simplified full- system runs, have been carried out, partially benchmarking the code. A magnetoinductive model, with module impedance and multi- beam effects, is under study. experiments, including an injector scalable to multi- beam arrays, a high-more » current beam transport and acceleration experiment, and a scaled final- focusing experiment. These ''phase I'' projects are laying the groundwork for the next major step in HIF development, the Integrated Research Experiment (IRE). Simulations aimed directly at the IRE must enable us to: design a facility with maximum power on target at minimal cost; set requirements for hardware tolerances, beam steering, etc.; and evaluate proposed chamber propagation modes. Finally, simulations must enable us to study all issues which arise in the context of a fusion driver, and must facilitate the assessment of driver options. In all of this, maximum advantage must be taken of emerging terascale computer architectures, requiring an aggressive code development effort. An organizing principle should be pursuit of the goal of integrated and detailed source- to- target simulation. methods for analysis of the beam dynamics in the various machine concepts, using moment- based methods for purposes of design, waveform synthesis, steering algorithm synthesis, etc. Three classes of discrete- particle models should be coupled: (1) electrostatic/ magnetoinductive PIC simulations should track the beams from the source through the final- focusing optics, passing details of the time- dependent distribution function to (2) electromagnetic or magnetoinductive PIC or hybrid PIG/ fluid simulations in the fusion chamber (which would finally pass their particle trajectory information to the radiation- hydrodynamics codes used for target design); in parallel, (3) detailed PIC, delta- f, core/ test- particle, and perhaps continuum Vlasov codes should be used to study individual sections of the driver and chamber very carefully; consistency may be assured by linking data from the PIC sequence, and knowledge gained may feed back into that sequence.« less

Diode-pumped solid-state laser driver experiments for inertial fusion energy applications

DOE Office of Scientific and Technical Information (OSTI.GOV)

Marshall, C.D.; Payne, S.A.; Emanuel, M.E.

Although solid-state lasers have been the primary means by which the physics of inertial confinement fusion (ICF) have been investigated, it was previously thought that solid-state laser technology could not offer adequate efficiencies for an inertial fusion energy (IFE) power plant. Orth and co-workers have recently designed a conceptual IFE power plant, however, with a high efficiency diode-pumped solid-state laser (DPSSL) driver that utilized several recent innovations in laser technology. It was concluded that DPSSLs could offer adequate performance for IFE with reasonable assumptions. This system was based on a novel diode pumped Yb-doped Sr{sub 5}(PO{sub 4}){sub 3}F (Yb:S-FAP) amplifier.more » Because this is a relatively new gain medium, a project was established to experimentally validate the diode-pumping and extraction dynamics of this system at the smallest reasonable scale. This paper reports on the initial experimental results of this study. We found the pumping dynamics and extraction cross-sections of Yb:S-FAP crystals to be similar to those previously inferred by purely spectroscopic techniques. The saturation fluence for pumping was measured to be 2.2 J/cm{sup 2} using three different methods based on either the spatial, temporal, or energy transmission properties of a Yb:S-FAP rod. The small signal gain implies an emission cross section of 6.0{times}10{sup {minus}20} cm{sup 2}. Up to 1.7 J/cm{sup 3} of stored energy density was achieved in a 6{times}6{times}44 mm{sup 3} Yb:S-FAP amplifier rod. In a free running configuration diode-pumped slope efficiencies up to 43% were observed with output energies up to {approximately}0.5 J per 1 ms pulse from a 3{times}3{times}30 mm{sup 3} rod. When the rod was mounted in a copper block for cooling, 13 W of average power was produced with power supply limited operation at 70 Hz with 500 {mu}s pulses.« less

Parameter space for the collective laser coupling in the laser fusion driver based on the concept of fiber amplification network.

PubMed

Huang, Zhihua; Lin, Honghuan; Xu, Dangpeng; Li, Mingzhong; Wang, Jianjun; Deng, Ying; Zhang, Rui; Zhang, Yongliang; Tian, Xiaocheng; Wei, Xiaofeng

2013-07-15

Collective laser coupling of the fiber array in the inertial confinement fusion (ICF) laser driver based on the concept of fiber amplification network (FAN) is researched. The feasible parameter space is given for laser coupling of the fundamental, second and third harmonic waves by neglecting the influence of the frequency conversion on the beam quality under the assumption of beam quality factor conservation. Third harmonic laser coupling is preferred due to its lower output energy requirement from a single fiber amplifier. For coplanar fiber array, the energy requirement is around 0.4 J with an effective mode field diameter of around 500 μm while maintaining the fundamental mode operation which is more than one order of magnitude higher than what can be achieved with state-of-the-art technology. Novel waveguide structure needs to be developed to enlarge the fundamental mode size while mitigating the catastrophic self-focusing effect.

Quasi-CW 110 kW AlGaAs Laser Diode Array Module for Inertial Fusion Energy Laser Driver

NASA Astrophysics Data System (ADS)

Kawashima, Toshiyuki; Kanzaki, Takeshi; Matsui, Ken; Kato, Yoshinori; Matsui, Hiroki; Kanabe, Tadashi; Yamanaka, Masanobu; Nakatsuka, Masahiro; Izawa, Yasukazu; Nakai, Sadao; Miyamoto, Masahiro; Kan, Hirofumi; Hiruma, Teruo

2001-12-01

We have successfully demonstrated a large aperture 803 nm AlGaAs diode laser module as a pump source for a 1053 nm, 10 J output Nd:glass slab laser amplifier for diode-pumped solid-state laser (DPSSL) fusion driver. Detailed performance results of the laser diode module are presented, including bar package and stack configuration, and their thermal design and analysis. A sufficiently low thermal impedance of the stack was realized by combining backplane liquid cooling configuration with modular bar package architecture. Total peak power of 110 kW and electrical to optical conversion efficiency of 46% were obtained from the module consisting of a total of 1000 laser diode bars. A peak intensity of 2.6 kW/cm2 was accomplished across an emitting area of 418 mm× 10 mm. Currently, this laser diode array module with a large two-dimensional aperture is, to our knowledge, the only operational pump source for the high output energy DPSSL.

An Oncogenic NTRK Fusion in a Patient with Soft-Tissue Sarcoma with Response to the Tropomyosin-Related Kinase Inhibitor LOXO-101.

PubMed

Doebele, Robert C; Davis, Lara E; Vaishnavi, Aria; Le, Anh T; Estrada-Bernal, Adriana; Keysar, Stephen; Jimeno, Antonio; Varella-Garcia, Marileila; Aisner, Dara L; Li, Yali; Stephens, Philip J; Morosini, Deborah; Tuch, Brian B; Fernandes, Michele; Nanda, Nisha; Low, Jennifer A

2015-10-01

Oncogenic TRK fusions induce cancer cell proliferation and engage critical cancer-related downstream signaling pathways. These TRK fusions occur rarely, but in a diverse spectrum of tumor histologies. LOXO-101 is an orally administered inhibitor of the TRK kinase and is highly selective only for the TRK family of receptors. Preclinical models of LOXO-101 using TRK-fusion-bearing human-derived cancer cell lines demonstrate inhibition of the fusion oncoprotein and cellular proliferation in vitro, and tumor growth in vivo. The tumor of a 41-year-old woman with soft-tissue sarcoma metastatic to the lung was found to harbor an LMNA-NTRK1 gene fusion encoding a functional LMNA-TRKA fusion oncoprotein as determined by an in situ proximity ligation assay. In a phase I study of LOXO-101 (ClinicalTrials.gov no. NCT02122913), this patient's tumors underwent rapid and substantial tumor regression, with an accompanying improvement in pulmonary dyspnea, oxygen saturation, and plasma tumor markers. TRK fusions have been deemed putative oncogenic drivers, but their clinical significance remained unclear. A patient with a metastatic soft-tissue sarcoma with an LMNA-NTRK1 fusion had rapid and substantial tumor regression with a novel, highly selective TRK inhibitor, LOXO-101, providing the first clinical evidence of benefit from inhibiting TRK fusions. ©2015 American Association for Cancer Research.

Sensor fusion: lane marking detection and autonomous intelligent cruise control system

NASA Astrophysics Data System (ADS)

Baret, Marc; Baillarin, S.; Calesse, C.; Martin, Lionel

1995-12-01

In the past few years MATRA and RENAULT have developed an Autonomous Intelligent Cruise Control (AICC) system based on a LIDAR sensor. This sensor incorporating a charge coupled device was designed to acquire pulsed laser diode emission reflected by standard car reflectors. The absence of moving mechanical parts, the large field of view, the high measurement rate and the very good accuracy for distance range and angular position of targets make this sensor very interesting. It provides the equipped car with the distance and the relative speed of other vehicles enabling the safety distance to be controlled by acting on the throttle and the automatic gear box. Experiments in various real traffic situations have shown the limitations of this kind of system especially on bends. All AICC sensors are unable to distinguish between a bend and a change of lane. This is easily understood if we consider a road without lane markings. This fact has led MATRA to improve its AICC system by providing the lane marking information. Also in the scope of the EUREKA PROMETHEUS project, MATRA and RENAULT have developed a lane keeping system in order to warn of the drivers lack of vigilance. Thus, MATRA have spread this system to far field lane marking detection and have coupled it with the AICC system. Experiments will be carried out on roads to estimate the gain in performance and comfort due to this fusion.

Cost Modeling and Design of Field-Reversed Configuration Fusion Power Plants

NASA Astrophysics Data System (ADS)

Kirtley, David; Slough, John; Helion Team

2017-10-01

The Inductively Driven Liner (IDL) fusion concept uses the magnetically driven implosion of thin (0.5-1 mm) Aluminum hoops to magnetically compress a merged Field-Reversed Configuration (FRC) plasma to fusion conditions. Both the driver and the target have been studied experimentally and theoretically by researchers at Helion Energy, MSNW, and the University of Washington, demonstrating compression fields greater than 100 T and suitable fusion targets. In the presented study, a notional power plant facility using this approach will be described. In addition, a full cost study based on the LLNL Z-IFE and HYLIFE-II studies, the ARIES Tokamak concept, and RAND power plant studies will be described. Finally, the expected capital costs, development requirements, and LCOE for 50 and 500 MW power plants will be given. This analysis includes core FRC plant scaling, metallic liner recycling, radiation shielding, operations, and facilities capital requirements.

PAX3-FOXO1: Zooming in on an "undruggable" target.

PubMed

Wachtel, Marco; Schäfer, Beat W

2018-06-01

Driver oncogenes are prime targets for therapy in tumors many of which, including leukemias and sarcomas, express recurrent fusion transcription factors. One specific example for such a cancer type is alveolar rhabdomyosarcoma, which is associated in the majority of cases with the fusion protein PAX3-FOXO1. Since fusion transcription factors are challenging targets for development of small molecule inhibitors, indirect inhibitory strategies for this type of oncogenes represent a more promising approach. One can envision strategies at different molecular levels including upstream modifiers and activators, epigenetic and transcriptional co-regulators, and downstream effector targets. In this review, we will discuss the current knowledge regarding potential therapeutic targets that might contribute to indirect interference with PAX3-FOXO1 activity in alveolar rhabdomyosarcoma at the different molecular levels and extrapolate these findings to fusion transcription factors in general. Copyright © 2017 The Authors. Published by Elsevier Ltd.. All rights reserved.

DOE Office of Scientific and Technical Information (OSTI.GOV)

D.A. Gates; J.R. Ferron; M. Bell

In 2003, the NSTX plasma control system was used for plasma shape control using real-time equilibrium reconstruction (using the rtEFIT code - J. Ferron, et al., Nucl. Fusion 38 1055 (1998)). rtEFIT is now in routine use for plasma boundary control [D. A. Gates, et al., submitted to Nuclear Fusion (2005)]. More recently, the system has been upgraded to support feedback control of the resistive wall mode (RWM). This paper describes the hardware and software improvements that were made in support of these physics requirements. The real-time data acquisition system now acquires 352 channels of data at 5kHz for eachmore » NSTX plasma discharge. The latency for the data acquisition, which uses the FPDP (Front Panel Data Port) protocol, is measured to be {approx}8 microseconds. A Stand-Alone digitizer (SAD), designed at PPPL, along with an FPDP Input multiplexing module (FIMM) allows for simple modular upgrades. An interface module was built to interface between the FPDP output of the NSTX control system and the legacy Power Conversion link (PCLINK) used for communicating with the PPPL power supplies (first used for TFTR). Additionally a module has been built for communicating with the switching power amplifiers (SPA) recently installed on NSTX. In addition to the hardware developments, the control software [D. Mastrovito, Fusion Eng. And Design 71 65 (2004)] on the NSTX control system has been upgraded. The control computer is an eight processor (8x333MHz G4) built by Sky Computers (Helmsford, MA). The device driver software for the hardware described above will be discussed, as well as the new control algorithms that have been developed to control the switching power supplies for RWM control. An important initial task in RWM feedback is to develop a reliable mode detection algorithm.« less

Conceptual design of the DEMO neutral beam injectors: main developments and R&D achievements

NASA Astrophysics Data System (ADS)

Sonato, P.; Agostinetti, P.; Bolzonella, T.; Cismondi, F.; Fantz, U.; Fassina, A.; Franke, T.; Furno, I.; Hopf, C.; Jenkins, I.; Sartori, E.; Tran, M. Q.; Varje, J.; Vincenzi, P.; Zanotto, L.

2017-05-01

The objectives of the nuclear fusion power plant DEMO, to be built after the ITER experimental reactor, are usually understood to lie somewhere between those of ITER and a ‘first of a kind’ commercial plant. Hence, in DEMO the issues related to efficiency and RAMI (reliability, availability, maintainability and inspectability) are among the most important drivers for the design, as the cost of the electricity produced by this power plant will strongly depend on these aspects. In the framework of the EUROfusion Work Package Heating and Current Drive within the Power Plant Physics and Development activities, a conceptual design of the neutral beam injector (NBI) for the DEMO fusion reactor has been developed by Consorzio RFX in collaboration with other European research institutes. In order to improve efficiency and RAMI aspects, several innovative solutions have been introduced in comparison to the ITER NBI, mainly regarding the beam source, neutralizer and vacuum pumping systems.

Statistical sensor fusion of ECG data using automotive-grade sensors

NASA Astrophysics Data System (ADS)

Koenig, A.; Rehg, T.; Rasshofer, R.

2015-11-01

Driver states such as fatigue, stress, aggression, distraction or even medical emergencies continue to be yield to severe mistakes in driving and promote accidents. A pathway towards improving driver state assessment can be found in psycho-physiological measures to directly quantify the driver's state from physiological recordings. Although heart rate is a well-established physiological variable that reflects cognitive stress, obtaining heart rate contactless and reliably is a challenging task in an automotive environment. Our aim was to investigate, how sensory fusion of two automotive grade sensors would influence the accuracy of automatic classification of cognitive stress levels. We induced cognitive stress in subjects and estimated levels from their heart rate signals, acquired from automotive ready ECG sensors. Using signal quality indices and Kalman filters, we were able to decrease Root Mean Squared Error (RMSE) of heart rate recordings by 10 beats per minute. We then trained a neural network to classify the cognitive workload state of subjects from heart rate and compared classification performance for ground truth, the individual sensors and the fused heart rate signal. We obtained an increase of 5 % higher correct classification by fusing signals as compared to individual sensors, staying only 4 % below the maximally possible classification accuracy from ground truth. These results are a first step towards real world applications of psycho-physiological measurements in vehicle settings. Future implementations of driver state modeling will be able to draw from a larger pool of data sources, such as additional physiological values or vehicle related data, which can be expected to drive classification to significantly higher values.

Fusion Breeding for Sustainable, Mid Century, Carbon Free Power

NASA Astrophysics Data System (ADS)

Manheimer, Wallace

2015-11-01

If ITER achieves Q ~10, it is still very far from useful fusion. The fusion power, and the driver power will allow only a small amount of power to be delivered, <~50MW for an ITER scale tokamak. It is unlikely, considering ``conservative design rules'' that tokamaks can ever be economical pure fusion power producers. Considering the status of other magnetic fusion concepts, it is also very unlikely that any alternate concept will either. Laser fusion does not seem to be constrained by any conservative design rules, but considering the failure of NIF to achhieve ignition, at this point it has many more obstacles to overcome than magnetic fusion. One way out of this dilemma is to use an ITER size tokamak, or a NIF size laser, as a fuel breeder for searate nuclear reactors. Hence ITER and NIF become ends in themselves, instead of steps to who knows what DEMO decades later. Such a tokamak can easily live within the consrtaints of conservative design rules. This has led the author to propose ``The Energy Park'' a sustainable, carbon free, economical, and environmently viable power source without prolifertion risk. It is one fusion breeder fuels 5 conventional nuclear reactors, and one fast neutron reactor burns the actinide wastes.

Preface to special topic: High-energy density laboratory astrophysics

DOE Office of Scientific and Technical Information (OSTI.GOV)

Glenzer, Siegfried H

Here, in the 1990s, when the large inertial confinement fusion facilities in the United States became accessible for discovery-class research, physicists soon realized that the combination of these energetic drivers with precision plasmas diagnostics would allow the unprecedented experimental study of astrophysical problems.

Preface to special topic: High-energy density laboratory astrophysics

DOE PAGES

Glenzer, Siegfried H

2017-04-11

Here, in the 1990s, when the large inertial confinement fusion facilities in the United States became accessible for discovery-class research, physicists soon realized that the combination of these energetic drivers with precision plasmas diagnostics would allow the unprecedented experimental study of astrophysical problems.

Amplicon-based next-generation sequencing of plasma cell-free DNA for detection of driver and resistance mutations in advanced non-small cell lung cancer.

PubMed

Guibert, N; Hu, Y; Feeney, N; Kuang, Y; Plagnol, V; Jones, G; Howarth, K; Beeler, J F; Paweletz, C P; Oxnard, G R

2018-04-01

Genomic analysis of plasma cell-free DNA is transforming lung cancer care; however, available assays are limited by cost, turnaround time, and imperfect accuracy. Here, we study amplicon-based plasma next-generation sequencing (NGS), rather than hybrid-capture-based plasma NGS, hypothesizing this would allow sensitive detection and monitoring of driver and resistance mutations in advanced non-small cell lung cancer (NSCLC). Plasma samples from patients with NSCLC and a known targetable genotype (EGFR, ALK/ROS1, and other rare genotypes) were collected while on therapy and analyzed blinded to tumor genotype. Plasma NGS was carried out using enhanced tagged amplicon sequencing of hotspots and coding regions from 36 genes, as well as intronic coverage for detection of ALK/ROS1 fusions. Diagnostic accuracy was compared with plasma droplet digital PCR (ddPCR) and tumor genotype. A total of 168 specimens from 46 patients were studied. Matched plasma NGS and ddPCR across 120 variants from 80 samples revealed high concordance of allelic fraction (R2 = 0.95). Pretreatment, sensitivity of plasma NGS for the detection of EGFR driver mutations was 100% (30/30), compared with 87% for ddPCR (26/30). A full spectrum of rare driver oncogenic mutations could be detected including sensitive detection of ALK/ROS1 fusions (8/9 detected, 89%). Studying 25 patients positive for EGFR T790M that developed resistance to osimertinib, 15 resistance mechanisms could be detected including tertiary EGFR mutations (C797S, Q791P) and mutations or amplifications of non-EGFR genes, some of which could be detected pretreatment or months before progression. This blinded analysis demonstrates the ability of amplicon-based plasma NGS to detect a full range of targetable genotypes in NSCLC, including fusion genes, with high accuracy. The ability of plasma NGS to detect a range of preexisting and acquired resistance mechanisms highlights its potential value as an alternative to single mutation digital PCR-based plasma assays for personalizing treatment of TKI resistance in lung cancer.

Drivers of Medicare Reimbursement for Thoracolumbar Fusion: An Analysis of Data From The Centers For Medicare and Medicaid Services.

PubMed

Khanna, Krishn; Padegimas, Eric M; Zmistowski, Benjamin; Howley, Michael; Verma, Kushagra

2017-11-01

A retrospective observational study. The purpose of this study is to examine the variation in thoracolumbar fusion (TLF) payment and determine the drivers of this variation. As health care spending continues to increase, variation in surgical procedures reimbursements has come under more scrutiny. TLF is an example of a high-cost, proven-benefit procedure that is often the focus of Centers for Medicare and Medicaid Services (CMS) administrators. There is a wide variation in TLF charges, but the drivers for this variation are not clear. Claims for TLF were identified in the CMS data by analyzing Diagnosis Related Group (DRG) number 460 ("Spinal Fusion Except Cervical without Major Complications or Comorbidities"). Data on factors that may impact cost of care were collected from four sources: the United States Census Bureau, CMS, the Dartmouth Atlas, and WWAMI Rural Health Research Center. These were then grouped into seven categories: quality, supply, demand, substitute treatment availability, patient characteristics, competitive factors, and provider characteristics. Predictive reimbursement models were created from the data using multivariate linear regression to understand the factors that influence TLF reimbursement. There was significant geographic variability in reimbursement. The largest contribution to reimbursement variation came from variables in the demand (ΔR = 13.4%, P < 0.001), supply (ΔR = 9.2%, P < 0.001), and competitive factor domains (ΔR = 9.1%, P < 0.001). The top three drivers that increased reimbursement were provider charges (β = 0.37, P < 0.001), total Medicare reimbursement in the region (β = 0.19, P < 0.001), and the number of spinal surgeries per 1000 patients in that region (β = 0.06, P = 0.02). Institutional volume, a surrogate for quality was negatively associated with TLF reimbursement. There was wide variation in reimbursement for TLF across the U.S. The variables that drive TLF reimbursement variation include supply, demand, and competition. Interestingly, quality of care was not associated with increased TLF reimbursement. N/A.

Renewability and sustainability aspects of nuclear energy

NASA Astrophysics Data System (ADS)

Şahin, Sümer

2014-09-01

Renewability and sustainability aspects of nuclear energy have been presented on the basis of two different technologies: (1) Conventional nuclear technology; CANDU reactors. (2) Emerging nuclear technology; fusion/fission (hybrid) reactors. Reactor grade (RG) plutonium, 233U fuels and heavy water moderator have given a good combination with respect to neutron economy so that mixed fuel made of (ThO2/RG-PuO2) or (ThC/RG-PuC) has lead to very high burn up grades. Five different mixed fuel have been selected for CANDU reactors composed of 4 % RG-PuO2 + 96 % ThO2; 6 % RG-PuO2 + 94 % ThO2; 10 % RG-PuO2 + 90 % ThO2; 20 % RG-PuO2 + 80 % ThO2; 30 % RG-PuO2 + 70 % ThO2, uniformly taken in each fuel rod in a fuel channel. Corresponding operation lifetimes have been found as ˜ 0.65, 1.1, 1.9, 3.5, and 4.8 years and with burn ups of ˜ 30 000, 60 000, 100 000, 200 000 and 290 000 MW.d/ton, respectively. Increase of RG-PuO2 fraction in radial direction for the purpose of power flattening in the CANDU fuel bundle has driven the burn up grade to 580 000 MW.d/ton level. A laser fusion driver power of 500 MWth has been investigated to burn the minor actinides (MA) out of the nuclear waste of LWRs. MA have been homogenously dispersed as carbide fuel in form of TRISO particles with volume fractions of 0, 2, 3, 4 and 5 % in the Flibe coolant zone in the blanket surrounding the fusion chamber. Tritium breeding for a continuous operation of the fusion reactor is calculated as TBR = 1.134, 1.286, 1.387, 1.52 and 1.67, respectively. Fission reactions in the MA fuel under high energetic fusion neutrons have lead to the multiplication of the fusion energy by a factor of M = 3.3, 4.6, 6.15 and 8.1 with 2, 3, 4 and 5 % TRISO volume fraction at start up, respectively. Alternatively with thorium, the same fusion driver would produce ˜160 kg 233U per year in addition to fission energy production in situ, multiplying the fusion energy by a factor of ˜1.3.

An antiproton driver for ICF propulsion

NASA Technical Reports Server (NTRS)

Chiang, Pi-Ren; Lewis, R. A.; Smith, G. A.; Gazze, C.; Higman, K.; Newton, R.; Chiaverini, M.; Dailey, J.; Surratt, M.; Werthman, W. Lance

1993-01-01

Inertial confinement fusion (ICF) utilizing an anitprotoncatalyzed target is discussed as a possible source of propulsion for rapid interplanetary manned space missions. The relevant compression, ignition, and thrust mechanisms are presented. Progress on an experiment presently in progress at the Phillips Laboratory, Kirtland AFB, NM to demonstrate proof-of-principle is reviewed.

Engineering and Functional Characterization of Fusion Genes Identifies Novel Oncogenic Drivers of Cancer.

PubMed

Lu, Hengyu; Villafane, Nicole; Dogruluk, Turgut; Grzeskowiak, Caitlin L; Kong, Kathleen; Tsang, Yiu Huen; Zagorodna, Oksana; Pantazi, Angeliki; Yang, Lixing; Neill, Nicholas J; Kim, Young Won; Creighton, Chad J; Verhaak, Roel G; Mills, Gordon B; Park, Peter J; Kucherlapati, Raju; Scott, Kenneth L

2017-07-01

Oncogenic gene fusions drive many human cancers, but tools to more quickly unravel their functional contributions are needed. Here we describe methodology permitting fusion gene construction for functional evaluation. Using this strategy, we engineered the known fusion oncogenes, BCR-ABL1, EML4-ALK , and ETV6-NTRK3, as well as 20 previously uncharacterized fusion genes identified in The Cancer Genome Atlas datasets. In addition to confirming oncogenic activity of the known fusion oncogenes engineered by our construction strategy, we validated five novel fusion genes involving MET, NTRK2 , and BRAF kinases that exhibited potent transforming activity and conferred sensitivity to FDA-approved kinase inhibitors. Our fusion construction strategy also enabled domain-function studies of BRAF fusion genes. Our results confirmed other reports that the transforming activity of BRAF fusions results from truncation-mediated loss of inhibitory domains within the N-terminus of the BRAF protein. BRAF mutations residing within this inhibitory region may provide a means for BRAF activation in cancer, therefore we leveraged the modular design of our fusion gene construction methodology to screen N-terminal domain mutations discovered in tumors that are wild-type at the BRAF mutation hotspot, V600. We identified an oncogenic mutation, F247L, whose expression robustly activated the MAPK pathway and sensitized cells to BRAF and MEK inhibitors. When applied broadly, these tools will facilitate rapid fusion gene construction for subsequent functional characterization and translation into personalized treatment strategies. Cancer Res; 77(13); 3502-12. ©2017 AACR . ©2017 American Association for Cancer Research.

Performance and Mix Measurements of Indirect Drive Cu-Doped Be Implosions

DOE Office of Scientific and Technical Information (OSTI.GOV)

Casey, D.  T.; Woods, D. T.; Smalyuk, V. A.

2015-05-19

The ablator couples energy between the driver and fusion fuel in inertial confinement fusion (ICF). Because of its low opacity, high solid density, and material properties, beryllium has long been considered an ideal ablator for ICF ignition experiments at the National Ignition Facility. We report here the first indirect drive Be implosions driven with shaped laser pulses and diagnosed with fusion yield at the OMEGA laser. The results show good performance with an average DD neutron yield of ~2 × 10⁹ at a convergence ratio of R₀/R ~ 10 and little impact due to the growth of hydrodynamic instabilities andmore » mix. In addition, the effect of adding an inner liner of W between the Be and DD is demonstrated.« less

Compact torus accelerator as a driver for ICF

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tobin, M.T.; Meier, W.R.; Morse, E.C.

1986-01-01

The authors have carried out further investigations of the technical issues associated with using a compact torus (CT) accelerator as a driver for inertial confinement fusion (ICF). In a CT accelerator, a magnetically confined, torus-shaped plasma is compressed, accelerated, and focused by two concentric electrodes. After its initial formation, the torus shape is maintained for lifetimes exceeding 1 ms by inherent poloidal and toroidal currents. Hartman suggests acceleration and focusing of such a plasma ring will not cause dissolution within certain constraints. In this study, we evaluated a point design based on an available capacitor bank energy of 9.2 MJ.more » This accelerator, which was modeled by a zero-dimensional code, produces a xenon plasma ring with a 0.73-cm radius, a velocity of 4.14 x 10/sup 9/ cm/s, and a mass of 4.42 ..mu..g. The energy of the plasma ring as it leaves the accelerator is 3.8 MJ, or 41% of the capacitor bank energy. Our studies confirm the feasibility of producing a plasma ring with the characteristics required to induce fusion in an ICF target with a gain greater than 50. The low cost and high efficiency of the CT accelerator are particularly attractive. Uncertainties concerning propagation, accelerator lifetime, and power supply must be resolved to establish the viability of the accelerator as an ICF driver.« less

Analysis of Anterior Cervical Discectomy and Fusion Healthcare Costs via the Value-Driven Outcomes Tool.

PubMed

Reese, Jared C; Karsy, Michael; Twitchell, Spencer; Bisson, Erica F

2018-04-11

Examining the costs of single- and multilevel anterior cervical discectomy and fusion (ACDF) is important for the identification of cost drivers and potentially reducing patient costs. A novel tool at our institution provides direct costs for the identification of potential drivers. To assess perioperative healthcare costs for patients undergoing an ACDF. Patients who underwent an elective ACDF between July 2011 and January 2017 were identified retrospectively. Factors adding to total cost were placed into subcategories to identify the most significant contributors, and potential drivers of total cost were evaluated using a multivariable linear regression model. A total of 465 patients (mean, age 53 ± 12 yr, 54% male) met the inclusion criteria for this study. The distribution of total cost was broken down into supplies/implants (39%), facility utilization (37%), physician fees (14%), pharmacy (7%), imaging (2%), and laboratory studies (1%). A multivariable linear regression analysis showed that total cost was significantly affected by the number of levels operated on, operating room time, and length of stay. Costs also showed a narrow distribution with few outliers and did not vary significantly over time. These results suggest that facility utilization and supplies/implants are the predominant cost contributors, accounting for 76% of the total cost of ACDF procedures. Efforts at lowering costs within these categories should make the most impact on providing more cost-effective care.

Adenoid cystic carcinoma: emerging role of translocations and gene fusions

PubMed Central

Wysocki, Piotr T.; Izumchenko, Evgeny; Meir, Juliet; Ha, Patrick K.; Sidransky, David; Brait, Mariana

2016-01-01

Adenoid cystic carcinoma (ACC), the second most common salivary gland malignancy, is notorious for poor prognosis, which reflects the propensity of ACC to progress to clinically advanced metastatic disease. Due to high long-term mortality and lack of effective systemic treatment, the slow-growing but aggressive ACC poses a particular challenge in head and neck oncology. Despite the advancements in cancer genomics, up until recently relatively few genetic alterations critical to the ACC development have been recognized. Although the specific chromosomal translocations resulting in MYB-NFIB fusions provide insight into the ACC pathogenesis and represent attractive diagnostic and therapeutic targets, their clinical significance is unclear, and a substantial subset of ACCs do not harbor the MYB-NFIB translocation. Strategies based on detection of newly described genetic events (such as MYB activating super-enhancer translocations and alterations affecting another member of MYB transcription factor family-MYBL1) offer new hope for improved risk assessment, therapeutic intervention and tumor surveillance. However, the impact of these approaches is still limited by an incomplete understanding of the ACC biology, and the manner by which these alterations initiate and drive ACC remains to be delineated. This manuscript summarizes the current status of gene fusions and other driver genetic alterations in ACC pathogenesis and discusses new therapeutic strategies stemming from the current research. PMID:27533466

Starlight: A stationary inertial-confinement-fusion reactor with nonvaporizing walls

NASA Astrophysics Data System (ADS)

Pitts, John H.

1989-09-01

The Starlight concept for an inertial-confinement-fusion (ICF) reactor utilizes a softball-sized solid-lithium x ray and debris shield that surrounds each fuel pellet as it is injected into the reactor. The shield is sacrificial and vaporizes as it absorbs x ray and ion-debris energy emanating from the fusion reactions in the fuel pellets. However, the energy deposition time at the surface if the first wall is lengthened by four orders of magnitude (to greater than 100 microns) which allows the energy to be conducted into the wall fast enough to prevent vaporization. Starlight operates at 5 Hz with 300-MJ-yield fuel pellets. It features a stationary, nonvaporizing first wall that eliminates erosion and shock waves which can destroy the wall; also, it allows arbitrary fuel pellet illumination geometries so that efficient coupling of either laser or heavy ion beam driver energy to the fuel pellet can be achieved. When neutrons penetrate the shield, the wall experiences neutron damage that limits its lifetime. Hence, we must choose wall materials that have ab economic lifetime. We describe the general concept and a specific design for laser drivers using a 6-m-radius, 2 1/4 Cr 1 Mo steel first wall. We include heat transfer calculations used to establish the radius and structural analysis that shows stresses are within allowable limits. A wall lifetime of over six years is predicted.

New Evaluated Semi-Empirical Formula Using Optical Model for 14-15 MeV ( n, t) Reaction Cross Sections

NASA Astrophysics Data System (ADS)

Tel, E.; Durgu, C.; Aydın, A.; Bölükdemir, M. H.; Kaplan, A.; Okuducu, Ş.

2009-12-01

In the next century the world will face the need for new energy sources. Nuclear fusion can be one of the most attractive sources of energy from the viewpoint of safety and minimal environmental impact. Fusion will not produce CO2 or SO2 and thus will not contribute to global warming or acid rain. Achieving acceptable performance for a fusion power system in the areas of economics, safety and environmental acceptability, is critically dependent on performance of the blanket and diverter systems which are the primary heat recovery, plasma purification, and tritium breeding systems. Tritium self-sufficiency must be maintained for a commercial power plant. The hybrid reactor is a combination of the fusion and fission processes. For self-sustaining (D-T) fusion driver tritium breeding ratio should be greater than 1.05. So working out the systematics of ( n, t) reaction cross-sections are of great importance for the definition of the excitation function character for the given reaction taking place on various nuclei at energies up to 20 MeV. In this study, we have calculated non-elastic cross-sections by using optical model for ( n, t) reactions at 14-15 MeV energy. We have investigated the excitation function character and reaction Q-values depending on the asymmetry term effect for the ( n, t) reaction cross-sections. We have obtained new coefficients for the ( n, t) reaction cross-sections. We have suggested semi-empirical formulas including optical model nonelastic effects by fitting two parameters for the ( n, t) reaction cross-sections at 14-15 MeV. We have discussed the odd-even effect and the pairing effect considering binding energy systematic of the nuclear shell model for the new experimental data and new cross-sections formulas ( n, t) reactions developed by Tel et al. We have determined a different parameter groups by the classification of nuclei into even-even, even-odd and odd-even for ( n, t) reactions cross-sections. The obtained cross-section formulas with new coefficients have been discussed and compared with the available experimental data.

The High Field Path to Practical Fusion Energy

NASA Astrophysics Data System (ADS)

Mumgaard, Robert; Whyte, D.; Greenwald, M.; Hartwig, Z.; Brunner, D.; Sorbom, B.; Marmar, E.; Minervini, J.; Bonoli, P.; Irby, J.; Labombard, B.; Terry, J.; Vieira, R.; Wukitch, S.

2017-10-01

We propose a faster, lower cost development path for fusion energy enabled by high temperature superconductors, devices at high magnetic field, innovative technologies and modern approaches to technology development. Timeliness, scale, and economic-viability are the drivers for fusion energy to combat climate change and aid economic development. The opportunities provided by high-temperature superconductors, innovative engineering and physics, and new organizational structures identified over the last few years open new possibilities for realizing practical fusion energy that could meet mid-century de-carbonization needs. We discuss re-factoring the fusion energy development path with an emphasis on concrete risk retirement strategies utilizing a modular approach based on the high-field tokamak that leverages the broader tokamak physics understanding of confinement, stability, and operational limits. Elements of this plan include development of high-temperature superconductor magnets, simplified immersion blankets, advanced long-leg divertors, a compact divertor test tokamak, efficient current drive, modular construction, and demountable magnet joints. An R&D plan culminating in the construction of an integrated pilot plant and test facility modeled on the ARC concept is presented.

Non-contact and noise tolerant heart rate monitoring using microwave doppler sensor and range imagery.

PubMed

Matsunag, Daichi; Izumi, Shintaro; Okuno, Keisuke; Kawaguchi, Hiroshi; Yoshimoto, Masahiko

2015-01-01

This paper describes a non-contact and noise-tolerant heart beat monitoring system. The proposed system comprises a microwave Doppler sensor and range imagery using Microsoft Kinect™. The possible application of the proposed system is a driver health monitoring. We introduce the sensor fusion approach to minimize the heart beat detection error. The proposed algorithm can subtract a body motion artifact from Doppler sensor output using time-frequency analysis. The body motion artifact is a crucially important problem for biosignal monitoring using microwave Doppler sensor. The body motion speed is obtainable from range imagery, which has 5-mm resolution at 30-cm distance. Measurement results show that the success rate of the heart beat detection is improved about 75% on average when the Doppler wave is degraded by the body motion artifact.

Analysis of EGFR, EML4-ALK, KRAS, and c-MET mutations in Chinese lung adenocarcinoma patients.

PubMed

Xia, Ning; An, Jian; Jiang, Qing-qing; Li, Min; Tan, Jun; Hu, Cheng-ping

2013-10-01

Mutation analysis of cancer driver genes is helpful for determining an optimal treatment strategy. We evaluated mutations in four driver genes, namely epidermal growth factor receptor (EGFR), Kirsten ras oncogene (KRAS), c-MET, and echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase (EML4-ALK), in Chinese lung adenocarcinoma patients from Hunan Province. We enrolled 110 lung adenocarcinoma patients in a single institution. EGFR and KRAS mutations were examined by direct sequencing, the EML4-ALK fusion gene was analyzed by fluorescence in situ hybridization, and c-MET amplification and c-Met protein expression were detected by quantitative PCR and immunohistochemistry, respectively. EGFR and KRAS mutations were observed in 52.7% (58/110) and 3.6% (4/106) of patients, respectively. c-MET amplification was detected in 5.5% (6/110) of patients. In addition, 30% (33/110) of the cases expressed c-Met protein, including all of the patients harboring c-MET amplification. Ten percent (11/110) of patients harbored the EML4-ALK fusion gene, and the frequency of ALK rearrangement was higher than that of other cohort analyses involving patients from other regions in China. Almost all of these gene mutations were exclusive except that in two female non-smoking patients, who harbored an EGFR mutation and EML4-ALK rearrangement simultaneously. In total, 70% of patients in the study harbored one of the four gene mutations. Most Chinese lung adenocarcinoma patients harbor driver gene mutations, among which ALK rearrangements were more common in Hunan patients than in previously reported populations. Future clinical trials should be conducted to determine the safety and efficacy of drug combination targeting different driver mutations.

Intelligent imaging systems for automotive applications

NASA Astrophysics Data System (ADS)

Thompson, Chris; Huang, Yingping; Fu, Shan

2004-03-01

In common with many other application areas, visual signals are becoming an increasingly important information source for many automotive applications. For several years CCD cameras have been used as research tools for a range of automotive applications. Infrared cameras, RADAR and LIDAR are other types of imaging sensors that have also been widely investigated for use in cars. This paper will describe work in this field performed in C2VIP over the last decade - starting with Night Vision Systems and looking at various other Advanced Driver Assistance Systems. Emerging from this experience, we make the following observations which are crucial for "intelligent" imaging systems: 1. Careful arrangement of sensor array. 2. Dynamic-Self-Calibration. 3. Networking and processing. 4. Fusion with other imaging sensors, both at the image level and the feature level, provides much more flexibility and reliability in complex situations. We will discuss how these problems can be addressed and what are the outstanding issues.

Magnetized Plasma Compression for Fusion Energy

NASA Astrophysics Data System (ADS)

Degnan, James; Grabowski, Christopher; Domonkos, Matthew; Amdahl, David

2013-10-01

Magnetized Plasma Compression (MPC) uses magnetic inhibition of thermal conduction and enhancement of charge particle product capture to greatly reduce the temporal and spatial compression required relative to un-magnetized inertial fusion (IFE)--to microseconds, centimeters vs nanoseconds, sub-millimeter. MPC greatly reduces the required confinement time relative to MFE--to microseconds vs minutes. Proof of principle can be demonstrated or refuted using high current pulsed power driven compression of magnetized plasmas using magnetic pressure driven implosions of metal shells, known as imploding liners. This can be done at a cost of a few tens of millions of dollars. If demonstrated, it becomes worthwhile to develop repetitive implosion drivers. One approach is to use arrays of heavy ion beams for energy production, though with much less temporal and spatial compression than that envisioned for un-magnetized IFE, with larger compression targets, and with much less ambitious compression ratios. A less expensive, repetitive pulsed power driver, if feasible, would require engineering development for transient, rapidly replaceable transmission lines such as envisioned by Sandia National Laboratories. Supported by DOE-OFES.

Linear Transformer Drivers for Z-pinch Based Propulsion

NASA Technical Reports Server (NTRS)

Adams, Robert; Seidler, William; Giddens, Patrick; Fabisinski, Leo; Cassibry, Jason

2017-01-01

The MSFC/UAH team has been developing of a novel power management and distribution system called a Linear Transformer Driver (LTD). LTD's hold the promise of dramatically reducing the required mass to drive a z-pinch by replacing the capacitor banks which constitute half the mass of the entire system. The MSFC?UAH tea, is developing this technology in hope of integrating it with the Pulsed Fission Fusion (PuFF) propulsion concept. High-Voltage pulsed power systems used for Z-Pinch experimentation have in the past largely been based on Marx Generators. Marx generators deliver the voltage and current required for the Z-Pinch, but suffer from two significant drawbacks when applied to a flight system: they are very massive, consisting of high-voltage capacitor banks insulated in oil-filled tanks and they do not lend themselves to rapid pulsing. The overall goal of Phase 2 is to demonstrate the construction of a higher voltage stack from a number of cavities each of the design proven in Phase 1 and to characterize and understand the techniques for designing the stack. The overall goal of Phase 3 is to demonstrate the feasibility of constructing a higher energy cavity from a number of smaller LTD stacks, to characterize and understand the way in which the constituent stacks combine, and to extend this demonstration LTD to serve as the basis for a 64 kJ pulse generator for Z-Pinch experiments.

Exploring lower-cost pathways to economical fusion power

DOE PAGES

Hsu, Scott C.

2017-08-04

This project, the Plasma Liner Experiment–ALPHA (PLX-α)5,is one of nine projects supported by the ALPHA Program6 of the Advanced Research Projects Agency–Energy (ARPA-E) of the U.S. Department of Energy (DOE). We use innovative, low-cost coaxial plasma guns (Fig. 1), developed and built by partner HyperV Technologies Corp.7, to launch a spherically converging array of supersonic plasma jets toward the middle of a large, spherical vacuum chamber (Fig. 2). A key near-term goal of PLX-α is to merge up to 60 plasma jets to form a spherically imploding plasma liner, as a low-cost, high-shot-rate driver for compressing magnetised target plasmas tomore » fusion conditions. Our approach is known as plasma-jet-driven MIF (or PJMIF)8. A new startup company HyperJet Fusion Corporation (which recently received seed funding from Strong Atomics, LLC, a new fusion venture fund) aims to develop PJMIF under continued public and private sponsorship.« less

Exploring lower-cost pathways to economical fusion power

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hsu, Scott C.

This project, the Plasma Liner Experiment–ALPHA (PLX-α)5,is one of nine projects supported by the ALPHA Program6 of the Advanced Research Projects Agency–Energy (ARPA-E) of the U.S. Department of Energy (DOE). We use innovative, low-cost coaxial plasma guns (Fig. 1), developed and built by partner HyperV Technologies Corp.7, to launch a spherically converging array of supersonic plasma jets toward the middle of a large, spherical vacuum chamber (Fig. 2). A key near-term goal of PLX-α is to merge up to 60 plasma jets to form a spherically imploding plasma liner, as a low-cost, high-shot-rate driver for compressing magnetised target plasmas tomore » fusion conditions. Our approach is known as plasma-jet-driven MIF (or PJMIF)8. A new startup company HyperJet Fusion Corporation (which recently received seed funding from Strong Atomics, LLC, a new fusion venture fund) aims to develop PJMIF under continued public and private sponsorship.« less

Investigation of plasma parameters at BATMAN for variation of the Cs evaporation asymmetry and comparing two driver geometries

NASA Astrophysics Data System (ADS)

Wimmer, C.; Fantz, U.; Aza, E.; Jovović, J.; Kraus, W.; Mimo, A.; Schiesko, L.

2017-08-01

The Neutral Beam Injection (NBI) system for fusion devices like ITER and, beyond ITER, DEMO requires large scale sources for negative hydrogen ions. BATMAN (Bavarian Test Machine for Negative ions) is a test facility attached with the prototype source for the ITER NBI (1/8 source size of the ITER source), dedicated to physical investigations due to its flexible access for diagnostics and exchange of source components. The required amount of negative ions is produced by surface conversion of hydrogen atoms or ions on caesiated surfaces. Several diagnostic tools (Optical Emission Spectroscopy, Cavity Ring-Down Spectroscopy for H-, Langmuir probes, Tunable Diode Laser Absorption Spectroscopy for Cs) allow the determination of plasma parameters in the ion source. Plasma parameters for two modifications of the standard prototype source have been investigated: Firstly, a second Cs oven has been installed in the bottom part of the back plate in addition to the regularly used oven in the top part of the back plate. Evaporation from the top oven only can lead to a vertically asymmetric Cs distribution in front of the plasma grid. Using both ovens, a symmetric Cs distribution can be reached - however, in most cases no significant change of the extracted ion current has been determined for varying Cs symmetry if the source is well-conditioned. Secondly, BATMAN has been equipped with a much larger, racetrack-shaped RF driver (area of 32×58 cm2) instead of the cylindrical RF driver (diameter of 24.5 cm). The main idea is that one racetrack driver could substitute two cylindrical drivers in larger sources with increased reliability and power efficiency. For the same applied RF power, the electron density is lower in the racetrack driver due to its five times higher volume. The fraction of hydrogen atoms to molecules, however, is at a similar level or even slightly higher, which is a promising result for application in larger sources.

RSPO3 expands intestinal stem cell and niche compartments and drives tumorigenesis.

PubMed

Hilkens, John; Timmer, Nikki C; Boer, Mandy; Ikink, Gerjon J; Schewe, Matthias; Sacchetti, Andrea; Koppens, Martijn A J; Song, Ji-Ying; Bakker, Elvira R M

2017-06-01

The gross majority of colorectal cancer cases results from aberrant Wnt/β-catenin signalling through adenomatous polyposis coli ( APC) or CTNNB1 mutations. However, a subset of human colon tumours harbour, mutually exclusive with APC and CTNNB1 mutations, gene fusions in RSPO2 or RSPO3, leading to enhanced expression of these R-spondin genes. This suggested that RSPO activation can substitute for the most common mutations as an alternative driver for intestinal cancer. Involvement of RSPO3 in tumour growth was recently shown in RSPO3 -fusion-positive xenograft models. The current study determines the extent into which solely a gain in RSPO3 actually functions as a driver of intestinal cancer in a direct, causal fashion, and addresses the in vivo activities of RSPO3 in parallel. We generated a conditional Rspo3 transgenic mouse model in which the Rspo3 transgene is expressed upon Cre activity. Cre is provided by cross-breeding with Lgr5 -GFP-Cre ERT2 mice. Upon in vivo Rspo3 expression, mice rapidly developed extensive hyperplastic, adenomatous and adenocarcinomatous lesions throughout the intestine. RSPO3 induced the expansion of Lgr5 + stem cells, Paneth cells, non-Paneth cell label-retaining cells and Lgr4 + cells, thus promoting both intestinal stem cell and niche compartments. Wnt/β-catenin signalling was modestly increased upon Rspo3 expression and mutant Kras synergised with Rspo3 in hyperplastic growth. We provide in vivo evidence that RSPO3 stimulates the crypt stem cell and niche compartments and drives rapid intestinal tumorigenesis. This establishes RSPO3 as a potent driver of intestinal cancer and proposes RSPO3 as a candidate target for therapy in patients with colorectal cancer harbouring RSPO3 fusions. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

Renewability and sustainability aspects of nuclear energy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Şahin, Sümer, E-mail: ssahin@atilim.edit.tr

Renewability and sustainability aspects of nuclear energy have been presented on the basis of two different technologies: (1) Conventional nuclear technology; CANDU reactors. (2) Emerging nuclear technology; fusion/fission (hybrid) reactors. Reactor grade (RG) plutonium, {sup 233}U fuels and heavy water moderator have given a good combination with respect to neutron economy so that mixed fuel made of (ThO{sub 2}/RG‐PuO{sub 2}) or (ThC/RG-PuC) has lead to very high burn up grades. Five different mixed fuel have been selected for CANDU reactors composed of 4 % RG‐PuO{sub 2} + 96 % ThO{sub 2}; 6 % RG‐PuO{sub 2} + 94 % ThO{sub 2};more » 10 % RG‐PuO{sub 2} + 90 % ThO{sub 2}; 20 % RG‐PuO{sub 2} + 80 % ThO{sub 2}; 30 % RG‐PuO{sub 2} + 70 % ThO{sub 2}, uniformly taken in each fuel rod in a fuel channel. Corresponding operation lifetimes have been found as ∼ 0.65, 1.1, 1.9, 3.5, and 4.8 years and with burn ups of ∼ 30 000, 60 000, 100 000, 200 000 and 290 000 MW.d/ton, respectively. Increase of RG‐PuO{sub 2} fraction in radial direction for the purpose of power flattening in the CANDU fuel bundle has driven the burn up grade to 580 000 MW.d/ton level. A laser fusion driver power of 500 MW{sub th} has been investigated to burn the minor actinides (MA) out of the nuclear waste of LWRs. MA have been homogenously dispersed as carbide fuel in form of TRISO particles with volume fractions of 0, 2, 3, 4 and 5 % in the Flibe coolant zone in the blanket surrounding the fusion chamber. Tritium breeding for a continuous operation of the fusion reactor is calculated as TBR = 1.134, 1.286, 1.387, 1.52 and 1.67, respectively. Fission reactions in the MA fuel under high energetic fusion neutrons have lead to the multiplication of the fusion energy by a factor of M = 3.3, 4.6, 6.15 and 8.1 with 2, 3, 4 and 5 % TRISO volume fraction at start up, respectively. Alternatively with thorium, the same fusion driver would produce ∼160 kg {sup 233}U per year in addition to fission energy production in situ, multiplying the fusion energy by a factor of ∼1.3.« less

Performance of the K+ ion diode in the 2 MV injector for heavy ion fusion

NASA Astrophysics Data System (ADS)

Bieniosek, F. M.; Henestroza, E.; Kwan, J. W.

2002-02-01

Heavy ion beam inertial fusion driver concepts depend on the availability and performance of high-brightness high-current ion sources. Surface ionization sources have relatively low current density but high brightness because of the low temperature of the emitted ions. We have measured the beam profiles at the exit of the injector diode, and compared the measured profiles with EGUN and WARP-3D predictions. Spherical aberrations are significant in this large aspect ratio diode. We discuss the measured and calculated beam size and beam profiles, the effect of aberrations, quality of vacuum, and secondary electron distributions on the beam profile.

Latent heat of traffic moving from rest

NASA Astrophysics Data System (ADS)

Farzad Ahmadi, S.; Berrier, Austin S.; Doty, William M.; Greer, Pat G.; Habibi, Mohammad; Morgan, Hunter A.; Waterman, Josam H. C.; Abaid, Nicole; Boreyko, Jonathan B.

2017-11-01

Contrary to traditional thinking and driver intuition, here we show that there is no benefit to ground vehicles increasing their packing density at stoppages. By systematically controlling the packing density of vehicles queued at a traffic light on a Smart Road, drone footage revealed that the benefit of an initial increase in displacement for close-packed vehicles is completely offset by the lag time inherent to changing back into a ‘liquid phase’ when flow resumes. This lag is analogous to the thermodynamic concept of the latent heat of fusion, as the ‘temperature’ (kinetic energy) of the vehicles cannot increase until the traffic ‘melts’ into the liquid phase. These findings suggest that in situations where gridlock is not an issue, drivers should not decrease their spacing during stoppages in order to lessen the likelihood of collisions with no loss in flow efficiency. In contrast, motion capture experiments of a line of people walking from rest showed higher flow efficiency with increased packing densities, indicating that the importance of latent heat becomes trivial for slower moving systems.

Alectinib shows potent antitumor activity against RET-rearranged non-small cell lung cancer.

PubMed

Kodama, Tatsushi; Tsukaguchi, Toshiyuki; Satoh, Yasuko; Yoshida, Miyuki; Watanabe, Yoshiaki; Kondoh, Osamu; Sakamoto, Hiroshi

2014-12-01

Alectinib/CH5424802 is a known inhibitor of anaplastic lymphoma kinase (ALK) and is being evaluated in clinical trials for the treatment of ALK fusion-positive non-small cell lung cancer (NSCLC). Recently, some RET and ROS1 fusion genes have been implicated as driver oncogenes in NSCLC and have become molecular targets for antitumor agents. This study aims to explore additional target indications of alectinib by testing its ability to inhibit the activity of kinases other than ALK. We newly verified that alectinib inhibited RET kinase activity and the growth of RET fusion-positive cells by suppressing RET phosphorylation. In contrast, alectinib hardly inhibited ROS1 kinase activity unlike other ALK/ROS1 inhibitors such as crizotinib and LDK378. It also showed antitumor activity in mouse models of tumors driven by the RET fusion. In addition, alectinib showed kinase inhibitory activity against RET gatekeeper mutations (RET V804L and V804M) and blocked cell growth driven by the KIF5B-RET V804L and V804M. Our results suggest that alectinib is effective against RET fusion-positive tumors. Thus, alectinib might be a therapeutic option for patients with RET fusion-positive NSCLC. ©2014 American Association for Cancer Research.

Pulsed Magnetic Field System for Magnetized Target Experiments at the National Ignition Facility

NASA Astrophysics Data System (ADS)

Rhodes, M. A.; Solberg, J. M.; Logan, B. G.; Perkins, L. J.

2014-10-01

High-magnitude magnetic fields applied to inertially confined targets may improve fusion yield and enable basic science applications. We discuss the development of a pulsed magnetic field system for NIF with the goal of applying 10--70 T to various NIF targets. While the driver may be little more than a spark-gap switched capacitor, numerous complex challenges exist in fielding such a system on NIF. The coil surrounding the metallic hohlraum drives induced current in the hohlraum wall. Both the coil and hohlraum wall must survive ohmic heating and J × B forces for several microseconds. Pulsed power must couple to the coil in the NIF environment. The system must not cause late-time optics damage due to debris. There is very limited volume for the driver in a NIF Diagnostic Instrument Manipulator (DIM). We are modeling the coil and hohlraum MHD effects with the LLNL code, ALE3D. However, the simulations lack complete and accurate data for all the required thermo-physical material properties over the expected range of temperatures (below vaporization) and pressures. Therefore, substantial experimental development is planned in the coming year. We present coil and hohlraum simulations results, overall system design, and progress towards an operational prototype test-stand. LLNL is operated by LLNS, LLC, for the U.S. D.O.E., NNSA under Contract DE-AC52-07NA27344. This work was supported by LLNL LDRD 14-ER-028.

Vehicle tracking for an evasive manoeuvres assistant using low-cost ultrasonic sensors.

PubMed

Jiménez, Felipe; Naranjo, José E; Gómez, Oscar; Anaya, José J

2014-11-28

Many driver assistance systems require knowledge of the vehicle environment. As these systems are increasing in complexity and performance, this knowledge of the environment needs to be more complete and reliable, so sensor fusion combining long, medium and short range sensors is now being used. This paper analyzes the feasibility of using ultrasonic sensors for low cost vehicle-positioning and tracking in the lane adjacent to the host vehicle in order to identify free areas around the vehicle and provide information to an automatic avoidance collision system that can perform autonomous braking and lane change manoeuvres. A laser scanner is used for the early detection of obstacles in the direction of travel while two ultrasonic sensors monitor the blind spot of the host vehicle. The results of tests on a test track demonstrate the ability of these sensors to accurately determine the kinematic variables of the obstacles encountered, despite a clear limitation in range.

Westinghouse ICF power plant study

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sucov, E. W.

1980-10-01

In this study, two different electric power plants for the production of about 1000 MWe which were based on a CO/sub 2/ laser driver and on a heavy ion driver have been developed and analyzed. The purposes of this study were: (1) to examine in a self consistent way the technological and institutional problems that need to be confronted and solved in order to produce commercially competitive electricity in the 2020 time frame from an inertial fusion reactor, and (2) to compare, on a common basis, the consequences of using two different drivers to initiate the DT fuel pellet explosions.more » Analytic descriptions of size/performance/cost relationships for each of the subsystems comprising the power plant have been combined into an overall computer code which models the entire plant. This overall model has been used to conduct trade studies which examine the consequences of varying critical design values around the reference point.« less

NUP160-SLC43A3 is a novel recurrent fusion oncogene in angiosarcoma.

PubMed

Shimozono, Naoki; Jinnin, Masatoshi; Masuzawa, Mamiko; Masuzawa, Mikio; Wang, Zhongzhi; Hirano, Ayaka; Tomizawa, Yukiko; Etoh-Kira, Tomomi; Kajihara, Ikko; Harada, Miho; Fukushima, Satoshi; Ihn, Hironobu

2015-11-01

Angiosarcoma is a malignant vascular tumor originating from endothelial cells of blood vessels or lymphatic vessels. The specific driver mutations in angiosarcoma remain unknown. In this study, we investigated this issue by transcriptome sequencing of patient-derived angiosarcoma cells (ISO-HAS), identifying a novel fusion gene NUP160-SLC43A3 found to be expressed in 9 of 25 human angiosarcoma specimens that were examined. In tumors harboring the fusion gene, the duration between the onset of symptoms and the first hospital visit was significantly shorter, suggesting more rapid tumor progression. Stable expression of the fusion gene in nontransformed human dermal microvascular endothelial cells elicited a gene-expression pattern mimicking ISO-HAS cells and increased cell proliferation, an effect traced in part to NUP160 truncation. Conversely, RNAi-mediated attenuation of NUP160 in ISO-HAS cells decreased cell number. Confirming the oncogenic effects of the fusion protein, subcutaneous implantation of NUP160-SLC43A3-expressing fibroblasts induced tumors resembling human angiosarcoma. Collectively, our findings advance knowledge concerning the genetic causes of angiosarcoma, with potential implications for new diagnostic and therapeutic approaches. ©2015 American Association for Cancer Research.

Dual drive coexistence of EML4-ALK and TPM3-ROS1 fusion in advanced lung adenocarcinoma.

PubMed

Zhu, You-Cai; Liao, Xing-Hui; Wang, Wen-Xian; Xu, Chun-Wei; Zhuang, Wu; Wei, Jian-Guo; Du, Kai-Qi

2018-02-01

We report a case of concomitant EML4-ALK and TPM3-ROS1 fusion in non-small cell lung cancer (NSCLC) in a 47-year-old Chinese man and review the clinical characteristics of this type double of fusion. The patient presented with a local tumor of the left upper lobe and underwent thoracoscopy. Postoperative surgical pathologic staging revealed T 1a N 0 M 0 stage IA. Histological examination of the tumor showed lung adenocarcinoma. Ventana ALK (D5F3) assay of the left lung tissue was ALK negative; however, immunohistochemical assay was positive for ROS1 protein. Using next generation sequencing, we found that the tumor had concomitant EML4-ALK and TPM3-ROS1 fusion. No recurrence was observed during seven months of follow-up. Precise diagnostic techniques allow the detection of concomitant ROS1 fusion and other driver genes, including ALK or EGFR; therefore oncologists should consider this rare double mutation in NSCLC patients. Further exploration of treatment models is required to provide additional therapeutic options. © 2017 The Authors. Thoracic Cancer published by China Lung Oncology Group and John Wiley & Sons Australia, Ltd.

1 Hz fast-heating fusion driver HAMA pumped by a 10 J green diode-pumped solid-state laser

NASA Astrophysics Data System (ADS)

Mori, Y.; Sekine, T.; Komeda, O.; Nakayama, S.; Ishii, K.; Hanayama, R.; Fujita, K.; Okihara, S.; Satoh, N.; Kurita, T.; Kawashima, T.; Kan, H.; Nakamura, N.; Kondo, T.; Fujine, M.; Azuma, H.; Hioki, T.; Kakeno, M.; Motohiro, T.; Nishimura, Y.; Sunahara, A.; Sentoku, Y.; Kitagawa, Y.

2013-07-01

A Ti : sapphire laser HAMA pumped by a diode-pumped solid-state laser (DPSSL) is developed to enable a high-repetitive inertial confinement fusion (ICF) experiment to be conducted. To demonstrate a counter-irradiation fast-heating fusion scheme, a 3.8 J, 0.4 ns amplified chirped pulse is divided into four beams: two counter-irradiate a target with intensities of 6 × 1013 W cm-2, and the remaining two are pulse-compressed to 110 fs for heating the imploded target with intensities of 2 × 1017 W cm-2. HAMA contributed to the first demonstration by showing that a 10 J class DPSSL is adaptable to ICF experiments and succeeded in DD neutron generation in the repetition mode. Based on HAMA, we can design and develop an integrated repetitive ICF experiment machine by including target injection and tracking.

Wavefront control of high-power laser beams in the National Ignition Facility (NIF)

NASA Astrophysics Data System (ADS)

Zacharias, Richard A.; Bliss, Erlan S.; Winters, Scott; Sacks, Richard A.; Feldman, Mark; Grey, Andrew; Koch, Jeffrey A.; Stolz, Christopher J.; Toeppen, John S.; Van Atta, Lewis; Woods, Bruce W.

2000-04-01

The use of lasers as the driver for inertial confinement fusion and weapons physics experiments is based on their ability to produce high-energy short pulses in a beam with low divergence. Indeed, the focusability of high quality laser beams far exceeds alternate technologies and is a major factor in the rationale for building high power lasers for such applications. The National Ignition Facility (NIF) is a large, 192-beam, high-power laser facility under construction at the Lawrence Livermore National Laboratory for fusion and weapons physics experiments. Its uncorrected minimum focal spot size is limited by laser system aberrations. The NIF includes a Wavefront Control System to correct these aberrations to yield a focal spot small enough for its applications. Sources of aberrations to be corrected include prompt pump-induced distortions in the laser amplifiers, previous-shot thermal distortions, beam off-axis effects, and gravity, mounting, and coating-induced optic distortions. Aberrations from gas density variations and optic-manufacturing figure errors are also partially corrected. This paper provides an overview of the NIF Wavefront Control System and describes the target spot size performance improvement it affords. It describes provisions made to accommodate the NIF's high fluence (laser beam and flashlamp), large wavefront correction range, wavefront temporal bandwidth, temperature and humidity variations, cleanliness requirements, and exception handling requirements (e.g. wavefront out-of-limits conditions).

The PLX- α project: demonstrating the viability of spherically imploding plasma liners as an MIF driver

NASA Astrophysics Data System (ADS)

Hsu, S. C.; Witherspoon, F. D.; Cassibry, J. T.; Gilmore, M.; Samulyak, R.; Stoltz, P.; the PLX-α Team

2015-11-01

Under ARPA-E's ALPHA program, the Plasma Liner Experiment-ALPHA (PLX- α) project aims to demonstrate the viability and scalability of spherically imploding plasma liners as a standoff, high-implosion-velocity magneto-inertial-fusion (MIF) driver that is potentially compatible with both low- and high- β targets. The project has three major objectives: (a) advancing existing contoured-gap coaxial-gun technology to achieve higher operational reliability/precision and better control/reproducibility of plasma-jet properties and profiles; (2) conducting ~ π / 2 -solid-angle plasma-liner experiments with 9 guns to demonstrate (along with extrapolations from modeling) that the jet-merging process leads to Mach-number degradation and liner uniformity that are acceptable for MIF; and (3) conducting 4 π experiments with up to 60 guns to demonstrate the formation of an imploding spherical plasma liner for the first time, and to provide empirical ram-pressure and uniformity scaling data for benchmarking our codes and informing us whether the scalings justify further development beyond ALPHA. This talk will provide an overview of the PLX- α project as well as key research results to date. Supported by ARPA-E's ALPHA program; original PLX construction supported by DOE Fusion Energy Sciences.

Physics Criteria for a Subscale Plasma Liner Experiment

DOE PAGES

Hsu, Scott C.; Thio, Yong C. Francis

2018-02-02

Spherically imploding plasma liners, formed by merging hypersonic plasma jets, are a proposed standoff driver to compress magnetized target plasmas to fusion conditions (Hsu et al. in IEEE Trans Plasma Sci 40:1287, 2012). Here, in this paper, the parameter space and physics criteria are identified for a subscale, plasma-liner-formation experiment to provide data, e.g., on liner ram-pressure scaling and uniformity, that are relevant for addressing scientific issues of full-scale plasma liners required to achieve fusion conditions. Lastly, based on these criteria, we quantitatively estimate the minimum liner kinetic energy and mass needed, which informed the design of a subscale plasmamore » liner experiment now under development.« less

Physics Criteria for a Subscale Plasma Liner Experiment

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hsu, Scott C.; Thio, Yong C. Francis

Spherically imploding plasma liners, formed by merging hypersonic plasma jets, are a proposed standoff driver to compress magnetized target plasmas to fusion conditions (Hsu et al. in IEEE Trans Plasma Sci 40:1287, 2012). Here, in this paper, the parameter space and physics criteria are identified for a subscale, plasma-liner-formation experiment to provide data, e.g., on liner ram-pressure scaling and uniformity, that are relevant for addressing scientific issues of full-scale plasma liners required to achieve fusion conditions. Lastly, based on these criteria, we quantitatively estimate the minimum liner kinetic energy and mass needed, which informed the design of a subscale plasmamore » liner experiment now under development.« less

A solar simulator-pumped gas laser for the direct conversion of solar energy

NASA Technical Reports Server (NTRS)

Weaver, W. R.; Lee, J. H.

1981-01-01

Most proposed space power systems are comprised of three general stages, including the collection of the solar radiation, the conversion to a useful form, and the transmission to a receiver. The solar-pumped laser, however, effectively eliminates the middle stage and offers direct photon-to-photon conversion. The laser is especially suited for space-to-space power transmission and communication because of minimal beam spread, low power loss over large distances, and extreme energy densities. A description is presented of the first gas laser pumped by a solar simulator that is scalable to high power levels. The lasant is an iodide C3F7I that as a laser-fusion driver has produced terawatt peak power levels.

Clinicopathological features of younger (aged ≤ 50 years) lung adenocarcinoma patients harboring the EML4-ALK fusion gene.

PubMed

Kometani, Takuro; Sugio, Kenji; Osoegawa, Atsushi; Seto, Takashi; Ichinose, Yukito

2018-05-01

The EML4-ALK fusion gene has recently been identified as a driver mutation in a subset of non-small cell lung cancers. In subsequent studies, EML4-ALK has been detected in a low percentage of patients, and was associated with a lack of EGFR or KRAS mutations, younger age, and adenocarcinoma with acinar histology. Cases with the EML4-ALK fusion gene were examined to clarify the clinicopathological characteristics of young adenocarcinoma patients. Between December 1998 and May 2009, 85 patients aged ≤ 50 with lung adenocarcinoma were treated at our hospital. We examined 49 samples from adenocarcinoma patients who underwent surgical resection, chemotherapy, and/or radiotherapy for the EML4-ALK gene. None of the patients received ALK inhibitors because these drugs had not been approved in Japan before 2012. EML4-ALK fusion genes were screened using multiplex reverse-transcription PCR assay, and were confirmed by direct sequencing. The EML4-ALK fusion gene was detected in five tumors (10.2%). One patient had stage IB disease, one had stage IIIA, and three had stage IV. Histologically, there was one solid adenocarcinoma, two acinar adenocarcinomas, and two papillary adenocarcinomas. EML4-ALK fusion genes were mutually exclusive to EGFR and KRAS mutations. The five-year survival rate was 59.4% in patients without EML4-ALK fusion and was not reached in patients with EML4-ALK fusion. The EML4-ALK fusion gene may be a strong oncogene in younger patients with lung adenocarcinoma. © 2018 The Authors. Thoracic Cancer published by China Lung Oncology Group and John Wiley & Sons Australia, Ltd.

Clinicopathological features of younger (aged ≤ 50 years) lung adenocarcinoma patients harboring the EML4‐ALK fusion gene

PubMed Central

Sugio, Kenji; Osoegawa, Atsushi; Seto, Takashi; Ichinose, Yukito

2018-01-01

Background The EML4‐ALK fusion gene has recently been identified as a driver mutation in a subset of non‐small cell lung cancers. In subsequent studies, EML4‐ALK has been detected in a low percentage of patients, and was associated with a lack of EGFR or KRAS mutations, younger age, and adenocarcinoma with acinar histology. Cases with the EML4‐ALK fusion gene were examined to clarify the clinicopathological characteristics of young adenocarcinoma patients. Methods Between December 1998 and May 2009, 85 patients aged ≤ 50 with lung adenocarcinoma were treated at our hospital. We examined 49 samples from adenocarcinoma patients who underwent surgical resection, chemotherapy, and/or radiotherapy for the EML4‐ALK gene. None of the patients received ALK inhibitors because these drugs had not been approved in Japan before 2012. EML4‐ALK fusion genes were screened using multiplex reverse‐transcription PCR assay, and were confirmed by direct sequencing. Results The EML4‐ALK fusion gene was detected in five tumors (10.2%). One patient had stage IB disease, one had stage IIIA, and three had stage IV. Histologically, there was one solid adenocarcinoma, two acinar adenocarcinomas, and two papillary adenocarcinomas. EML4‐ALK fusion genes were mutually exclusive to EGFR and KRAS mutations. The five‐year survival rate was 59.4% in patients without EML4‐ALK fusion and was not reached in patients with EML4‐ALK fusion. Conclusion The EML4‐ALK fusion gene may be a strong oncogene in younger patients with lung adenocarcinoma. PMID:29517858

New methods in WARP, a particle-in-cell code for space-charge dominated beams

DOE Office of Scientific and Technical Information (OSTI.GOV)

Grote, D., LLNL

1998-01-12

The current U.S. approach for a driver for inertial confinement fusion power production is a heavy-ion induction accelerator; high-current beams of heavy ions are focused onto the fusion target. The space-charge of the high-current beams affects the behavior more strongly than does the temperature (the beams are described as being ``space-charge dominated``) and the beams behave like non-neutral plasmas. The particle simulation code WARP has been developed and used to study the transport and acceleration of space-charge dominated ion beams in a wide range of applications, from basic beam physics studies, to ongoing experiments, to fusion driver concepts. WARP combinesmore » aspects of a particle simulation code and an accelerator code; it uses multi-dimensional, electrostatic particle-in-cell (PIC) techniques and has a rich mechanism for specifying the lattice of externally applied fields. There are both two- and three-dimensional versions, the former including axisymmetric (r-z) and transverse slice (x-y) models. WARP includes a number of novel techniques and capabilities that both enhance its performance and make it applicable to a wide range of problems. Some of these have been described elsewhere. Several recent developments will be discussed in this paper. A transverse slice model has been implemented with the novel capability of including bends, allowing more rapid simulation while retaining essential physics. An interface using Python as the interpreter layer instead of Basis has been developed. A parallel version of WARP has been developed using Python.« less

MYBL1 rearrangements and MYB amplification in breast adenoid cystic carcinomas lacking the MYB-NFIB fusion gene.

PubMed

Kim, Jisun; Geyer, Felipe C; Martelotto, Luciano G; Ng, Charlotte Ky; Lim, Raymond S; Selenica, Pier; Li, Anqi; Pareja, Fresia; Fusco, Nicola; Edelweiss, Marcia; Kumar, Rahul; Gularte-Merida, Rodrigo; Forbes, Andre N; Khurana, Ekta; Mariani, Odette; Badve, Sunil; Vincent-Salomon, Anne; Norton, Larry; Reis-Filho, Jorge S; Weigelt, Britta

2018-02-01

Breast adenoid cystic carcinoma (AdCC), a rare type of triple-negative breast cancer, has been shown to be driven by MYB pathway activation, most often underpinned by the MYB-NFIB fusion gene. Alternative genetic mechanisms, such as MYBL1 rearrangements, have been reported in MYB-NFIB-negative salivary gland AdCCs. Here we report on the molecular characterization by massively parallel sequencing of four breast AdCCs lacking the MYB-NFIB fusion gene. In two cases, we identified MYBL1 rearrangements (MYBL1-ACTN1 and MYBL1-NFIB), which were associated with MYBL1 overexpression. A third AdCC harboured a high-level MYB amplification, which resulted in MYB overexpression at the mRNA and protein levels. RNA-sequencing and whole-genome sequencing revealed no definite alternative driver in the fourth AdCC studied, despite high levels of MYB expression and the activation of pathways similar to those activated in MYB-NFIB-positive AdCCs. In this case, a deletion encompassing the last intron and part of exon 15 of MYB, including the binding site of ERG-1, a transcription factor that may downregulate MYB, and the exon 15 splice site, was detected. In conclusion, we demonstrate that MYBL1 rearrangements and MYB amplification probably constitute alternative genetic drivers of breast AdCCs, functioning through MYBL1 or MYB overexpression. These observations emphasize that breast AdCCs probably constitute a convergent phenotype, whereby activation of MYB and MYBL1 and their downstream targets can be driven by the MYB-NFIB fusion gene, MYBL1 rearrangements, MYB amplification, or other yet to be identified mechanisms. Copyright © 2017 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd. Copyright © 2017 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.

Magnetized Target Fusion Driven by Plasma Liners

NASA Technical Reports Server (NTRS)

Thio, Y. C. Francis; Eskridge, Richard; Smith, James; Lee, Michael; Richeson, Jeff; Schmidt, George; Knapp, Charles E.; Kirkpatrick, Ronald C.; Turchi, Peter J.; Rodgers, Stephen L. (Technical Monitor)

2001-01-01

Magnetized target fusion (MTF) attempts to combine the favorable attributes of magnetic confinement fusion (MCF) for energy confinement with the attributes of inertial confinement fusion (ICF) for efficient compression heating and wall-free containment of the fusing plasma. It uses a material liner to compress and contain a magnetized plasma. For practical applications, standoff drivers to deliver the imploding momentum flux to the target plasma remotely are required. Spherically converging plasma jets have been proposed as standoff drivers for this purpose. The concept involves the dynamic formation of a spherical plasma liner by the merging of plasma jets, and the use of the liner so formed to compress a spheromak or a field reversed configuration (FRC). For the successful implementation of the scheme, plasma jets of the requisite momentum flux density need to be produced. Their transport over sufficiently large distances (a few meters) needs to be assured. When they collide and merge into a liner, relative differences in velocity, density and temperature of the jets could give rise to instabilities in the development of the liner. Variation in the jet properties must be controlled to ensure that the growth rate of the instabilities are not significant over the time scale of the liner formation before engaging with the target plasma. On impact with the target plasma, some plasma interpenetration might occur between the liner and the target. The operating parameter space needs to be identified to ensure that a reasonably robust and conducting contact surface is formed between the liner and the target. A mismatch in the "impedance" between the liner and the target plasma could give rise to undesirable shock heating of the liner leading to increased entropy (thermal losses) in the liner. Any irregularities in the liner will accentuate the Rayleigh-Taylor instabilities during the compression of the target plasma by the liner.

Simulator training with a forward collision warning system: effects on driver-system interactions and driver trust.

PubMed

Koustanaï, Arnaud; Cavallo, Viola; Delhomme, Patricia; Mas, Arnaud

2012-10-01

The study addressed the role of familiarization on a driving simulator with a forward collision warning (FCW) and investigated its impact on driver behavior. Drivers need a good understanding of how an FCW system functions to trust it and use it properly. Theoretical and empirical data suggest that exploring the capacities and limitations of the FCW during the learning period improves operating knowledge and leads to increased driver trust in the system and better driver-system interactions.The authors tested this hypothesis by comparing groups of drivers differing in FCW familiarity. During the familiarization phase, familiarized drivers were trained on the simulator using the FCW, unfamiliarized drivers simply read an FCW manual, and control drivers had no contact with the FCW. During the test, drivers drove the simulator and had to interact with traffic; both familiarized and unfamiliarized drivers used the FCW, whereas controls did not. Simulator familiarization improved driver understanding of FCW operation. Driver-system interactions were more effective: Familiarized drivers had no collisions, longer time headways, and better reactions in most situations. Familiarization increased trust in the FCW but did not raise system acceptance. Familiarization on the simulator had a positive effect on driver-system interactions and on trust in the system. The limitations of the familiarization method are discussed in relation to the driving simulator methodology. Practicing on a driving simulator with driving-assistance systems could facilitate their use during real driving.

Cross Sections Calculations of ( d, t) Nuclear Reactions up to 50 MeV

NASA Astrophysics Data System (ADS)

Tel, E.; Yiğit, M.; Tanır, G.

2013-04-01

In nuclear fusion reactions two light atomic nuclei fuse together to form a heavier nucleus. Fusion power is the power generated by nuclear fusion processes. In contrast with fission power, the fusion reaction processes does not produce radioactive nuclides. The fusion will not produce CO2 or SO2. So the fusion energy will not contribute to environmental problems such as particulate pollution and excessive CO2 in the atmosphere. Fusion powered electricity generation was initially believed to be readily achievable, as fission power had been. However, the extreme requirements for continuous reactions and plasma containment led to projections being extended by several decades. In 2010, more than 60 years after the first attempts, commercial power production is still believed to be unlikely before 2050. Although there have been significant research and development studies on the inertial and magnetic fusion reactor technology, there is still a long way to go to penetrate commercial fusion reactors to the energy market. In the fusion reactor, tritium self-sufficiency must be maintained for a commercial power plant. Therefore, for self-sustaining (D-T) fusion driver tritium breeding ratio should be greater than 1.05. Working out the systematics of ( d, t) nuclear reaction cross sections is of great importance for the definition of the excitation function character for the given reaction taking place on various nuclei at different energies. Since the experimental data of charged particle induced reactions are scarce, self-consistent calculation and analyses using nuclear theoretical models are very important. In this study, ( d, t) cross sections for target nuclei 19F, 50Cr, 54Fe, 58Ni, 75As, 89Y, 90Zr, 107Ag, 127I, 197Au and 238U have been investigated up to 50 MeV deuteron energy. The excitation functions for ( d, t) reactions have been calculated by pre-equilibrium reaction mechanism. Calculation results have been also compared with the available measurements in literature.

System integration of RF based negative ion experimental facility at IPR

NASA Astrophysics Data System (ADS)

Bansal, G.; Bandyopadhyay, M.; Singh, M. J.; Gahlaut, A.; Soni, J.; Pandya, K.; Parmar, K. G.; Sonara, J.; Chakraborty, A.

2010-02-01

The setting up of RF based negative ion experimental facility shall witness the beginning of experiments on the negative ion source fusion applications in India. A 1 MHz RF generator shall launch 100 kW RF power into a single driver on the plasma source to produce a plasma of density ~5 × 1012 cm-3. The source can deliver a negative ion beam of ~10 A with a current density of ~30 mA/cm2 and accelerated to 35 kV through an electrostatic ion accelerator. The experimental system is similar to a RF based negative ion source, BATMAN, presently operating at IPP. The subsystems for source operation are designed and procured principally from indigenous resources, keeping the IPP configuration as a base line. The operation of negative ion source is supported by many subsystems e.g. vacuum pumping system with gate valves, cooling water system, gas feed system, cesium delivery system, RF generator, high voltage power supplies, data acquisition and control system, and different diagnostics. The first experiments of negative ion source are expected to start at IPR from the middle of 2009.

FUSION ENERGY SCIENCES WORKSHOP ON PLASMA MATERIALS INTERACTIONS: Report on Science Challenges and Research Opportunities in Plasma Materials Interactions

DOE Office of Scientific and Technical Information (OSTI.GOV)

Maingi, Rajesh; Zinkle, Steven J.; Foster, Mark S.

2015-05-01

The realization of controlled thermonuclear fusion as an energy source would transform society, providing a nearly limitless energy source with renewable fuel. Under the auspices of the U.S. Department of Energy, the Fusion Energy Sciences (FES) program management recently launched a series of technical workshops to “seek community engagement and input for future program planning activities” in the targeted areas of (1) Integrated Simulation for Magnetic Fusion Energy Sciences, (2) Control of Transients, (3) Plasma Science Frontiers, and (4) Plasma-Materials Interactions aka Plasma-Materials Interface (PMI). Over the past decade, a number of strategic planning activities1-6 have highlighted PMI and plasmamore » facing components as a major knowledge gap, which should be a priority for fusion research towards ITER and future demonstration fusion energy systems. There is a strong international consensus that new PMI solutions are required in order for fusion to advance beyond ITER. The goal of the 2015 PMI community workshop was to review recent innovations and improvements in understanding the challenging PMI issues, identify high-priority scientific challenges in PMI, and to discuss potential options to address those challenges. The community response to the PMI research assessment was enthusiastic, with over 80 participants involved in the open workshop held at Princeton Plasma Physics Laboratory on May 4-7, 2015. The workshop provided a useful forum for the scientific community to review progress in scientific understanding achieved during the past decade, and to openly discuss high-priority unresolved research questions. One of the key outcomes of the workshop was a focused set of community-initiated Priority Research Directions (PRDs) for PMI. Five PRDs were identified, labeled A-E, which represent community consensus on the most urgent near-term PMI scientific issues. For each PRD, an assessment was made of the scientific challenges, as well as a set of actions to address those challenges. No prioritization was attempted amongst these five PRDs. We note that ITER, an international collaborative project to substantially extend fusion science and technology, is implicitly a driver and beneficiary of the research described in these PRDs; specific ITER issues are discussed in the background and PRD chapters. For succinctness, we describe these PRDs directly below; a brief introduction to magnetic fusion and the workshop process/timeline is given in Chapter I, and panelists are listed in the Appendix.« less

Progress in Direct-Drive Inertial Confinement Fusion

DOE Office of Scientific and Technical Information (OSTI.GOV)

McCrory, R.L.; Meyerhofer, D.D.; Betti, R.

Significant progress in direct-drive inertial confinement fusion (ICF) research has been made since the completion of the 60-beam, 30-kJ UV OMEGA Laser System [T. R. Boehly, Opt. Commun. 133, 495 (1997)] in 1995. A theory of ignition requirements, applicable to any ICF concept, has been developed. Detailed understanding of laser-plasma coupling, electron thermal transport, and hot-electron preheating has lead to the measurement of neutron-averaged areal densities of ~200 mg/cm^2 in cryogenic target implosions. These correspond to an estimated peak fuel density in excess of 100 g/cm^3 and are in good agreement with hydrodynamic simulations. The implosions were performed using anmore » 18-kJ drive pulse designed to put the converging fuel on an adiabat of two. The polar-drive concept will allow direct-drive-ignition research on the National Ignition Facility while it is configured for indirect drive. Advanced ICF ignition concepts—fast ignition [Tabak et al., Phys. Plasmas 1, 1626 (1994)] and shock ignition [R. Betti et al., Phys. Rev. Lett. 98, 155001 (2007)]—have the potential to significantly reduce ignition driver energies and/or provide higher target gain.« less

Progress in direct-drive inertial confinement fusion

DOE Office of Scientific and Technical Information (OSTI.GOV)

McCrory, R. L.; Meyerhofer, D. D.; Betti, R.

Significant progress in direct-drive inertial confinement fusion (ICF) research has been made since the completion of the 60-beam, 30-kJ{sub UV} OMEGA Laser System [Boehly, Opt. Commun. 133, 495 (1997)] in 1995. A theory of ignition requirements, applicable to any ICF concept, has been developed. Detailed understanding of laser-plasma coupling, electron thermal transport, and hot-electron preheating has lead to the measurement of neutron-averaged areal densities of {approx}200 mg/cm{sup 2} in cryogenic target implosions. These correspond to an estimated peak fuel density in excess of 100 g/cm{sup 3} and are in good agreement with hydrodynamic simulations. The implosions were performed using anmore » 18-kJ drive pulse designed to put the converging fuel on an adiabat of two. The polar-drive concept will allow direct-drive-ignition research on the National Ignition Facility while it is configured for indirect drive. Advanced ICF ignition concepts - fast ignition [Tabak et al., Phys. Plasmas 1, 1626 (1994)] and shock ignition [Betti et al., Phys. Rev. Lett. 98, 155001 (2007)] - have the potential to significantly reduce ignition driver energies and/or provide higher target gain.« less

A Study of Feature Combination for Vehicle Detection Based on Image Processing

PubMed Central

2014-01-01

Video analytics play a critical role in most recent traffic monitoring and driver assistance systems. In this context, the correct detection and classification of surrounding vehicles through image analysis has been the focus of extensive research in the last years. Most of the pieces of work reported for image-based vehicle verification make use of supervised classification approaches and resort to techniques, such as histograms of oriented gradients (HOG), principal component analysis (PCA), and Gabor filters, among others. Unfortunately, existing approaches are lacking in two respects: first, comparison between methods using a common body of work has not been addressed; second, no study of the combination potentiality of popular features for vehicle classification has been reported. In this study the performance of the different techniques is first reviewed and compared using a common public database. Then, the combination capabilities of these techniques are explored and a methodology is presented for the fusion of classifiers built upon them, taking into account also the vehicle pose. The study unveils the limitations of single-feature based classification and makes clear that fusion of classifiers is highly beneficial for vehicle verification. PMID:24672299

Experimental Results for an Acoustic Driver for MTF

NASA Astrophysics Data System (ADS)

Laberge, Michel

2009-06-01

General Fusion is planning to form an FRC or spheromak of 1017 cm-3, 100 eV, 40 cm diameter by merging two spheromaks with reverse or co-helicity. This target will be further compressed in a 3 m diameter tank filled with liquid PbLi with the plasma in the center. The tank is surrounded with pneumatically powered impact pistons that will send a convergent shock wave in the liquid to compress the plasma to 1020 cm-3, 10 keV, 4 cm diameter for 7 μs. General Fusion has built a 500 kJ, 80 μs, 6 GW pneumatic impact piston capable of developing 2 GPa (300 kpsi). In this paper we will present the performances achieved to date.

Measurement of signal use and vehicle turns as indication of driver cognition.

PubMed

Wallace, Bruce; Goubran, Rafik; Knoefel, Frank

2014-01-01

This paper uses data analytics to provide a method for the measurement of a key driving task, turn signal usage as a measure of an automatic over-learned cognitive function drivers. The paper augments previously reported more complex executive function cognition measures by proposing an algorithm that analyzes dashboard video to detect turn indicator use with 100% accuracy without any false positives. The paper proposes two algorithms that determine the actual turns made on a trip. The first through analysis of GPS location traces for the vehicle, locating 73% of the turns made with a very low false positive rate of 3%. A second algorithm uses GIS tools to retroactively create turn by turn directions. Fusion of GIS and GPS information raises performance to 77%. The paper presents the algorithm required to measure signal use for actual turns by realigning the 0.2Hz GPS data, 30fps video and GIS turn events. The result is a measure that can be tracked over time and changes in the driver's performance can result in alerts to the driver, caregivers or clinicians as indication of cognitive change. A lack of decline can also be shared as reassurance.

Survey on Ranging Sensors and Cooperative Techniques for Relative Positioning of Vehicles

PubMed Central

de Ponte Müller, Fabian

2017-01-01

Future driver assistance systems will rely on accurate, reliable and continuous knowledge on the position of other road participants, including pedestrians, bicycles and other vehicles. The usual approach to tackle this requirement is to use on-board ranging sensors inside the vehicle. Radar, laser scanners or vision-based systems are able to detect objects in their line-of-sight. In contrast to these non-cooperative ranging sensors, cooperative approaches follow a strategy in which other road participants actively support the estimation of the relative position. The limitations of on-board ranging sensors regarding their detection range and angle of view and the facility of blockage can be approached by using a cooperative approach based on vehicle-to-vehicle communication. The fusion of both, cooperative and non-cooperative strategies, seems to offer the largest benefits regarding accuracy, availability and robustness. This survey offers the reader a comprehensive review on different techniques for vehicle relative positioning. The reader will learn the important performance indicators when it comes to relative positioning of vehicles, the different technologies that are both commercially available and currently under research, their expected performance and their intrinsic limitations. Moreover, the latest research in the area of vision-based systems for vehicle detection, as well as the latest work on GNSS-based vehicle localization and vehicular communication for relative positioning of vehicles, are reviewed. The survey also includes the research work on the fusion of cooperative and non-cooperative approaches to increase the reliability and the availability. PMID:28146129

The Equilibrium and Pre-equilibrium Triton Emission Spectra of Some Target Nuclei for ( n, xt) Reactions up to 45 MeV Energy

NASA Astrophysics Data System (ADS)

Tel, E.; Kaplan, A.; Aydın, A.; Özkorucuklu, S.; Büyükuslu, H.; Yıldırım, G.

2010-08-01

Although there have been significant research and development studies on the inertial and magnetic fusion reactor technology, there is still a long way to go to penetrate commercial fusion reactors to the energy market. Tritium self-sufficiency must be maintained for a commercial power plant. For self-sustaining (D-T) fusion driver tritium breeding ratio should be greater than 1.05. So, working out the systematics of ( n,t) reaction cross sections and triton emission differential data are important for the given reaction taking place on various nuclei at different energies. In this study, ( n,xt) reactions for some target nuclei as 16O, 27Al, 59Co and 209Bi have been investigated up to 45 MeV incident neutron energy. In the calculations of the triton emission spectra, the pre-equilibrium and equilibrium effects have been used. The calculated results have been compared with the experimental data taken from the literature.

Integrating millimeter wave radar with a monocular vision sensor for on-road obstacle detection applications.

PubMed

Wang, Tao; Zheng, Nanning; Xin, Jingmin; Ma, Zheng

2011-01-01

This paper presents a systematic scheme for fusing millimeter wave (MMW) radar and a monocular vision sensor for on-road obstacle detection. As a whole, a three-level fusion strategy based on visual attention mechanism and driver's visual consciousness is provided for MMW radar and monocular vision fusion so as to obtain better comprehensive performance. Then an experimental method for radar-vision point alignment for easy operation with no reflection intensity of radar and special tool requirements is put forward. Furthermore, a region searching approach for potential target detection is derived in order to decrease the image processing time. An adaptive thresholding algorithm based on a new understanding of shadows in the image is adopted for obstacle detection, and edge detection is used to assist in determining the boundary of obstacles. The proposed fusion approach is verified through real experimental examples of on-road vehicle/pedestrian detection. In the end, the experimental results show that the proposed method is simple and feasible.

Vehicle Tracking for an Evasive Manoeuvres Assistant Using Low-Cost Ultrasonic Sensors

PubMed Central

Jiménez, Felipe; Naranjo, José E.; Gómez, Oscar; Anaya, José J.

2014-01-01

Many driver assistance systems require knowledge of the vehicle environment. As these systems are increasing in complexity and performance, this knowledge of the environment needs to be more complete and reliable, so sensor fusion combining long, medium and short range sensors is now being used. This paper analyzes the feasibility of using ultrasonic sensors for low cost vehicle-positioning and tracking in the lane adjacent to the host vehicle in order to identify free areas around the vehicle and provide information to an automatic avoidance collision system that can perform autonomous braking and lane change manoeuvres. A laser scanner is used for the early detection of obstacles in the direction of travel while two ultrasonic sensors monitor the blind spot of the host vehicle. The results of tests on a test track demonstrate the ability of these sensors to accurately determine the kinematic variables of the obstacles encountered, despite a clear limitation in range. PMID:25460817

NASA Tech Briefs, November 2013

NASA Technical Reports Server (NTRS)

2013-01-01

Topics include: Cryogenic Liquid Sample Acquisition System for Remote Space Applications; 5 Spatial Statistical Data Fusion (SSDF); GPS Estimates of Integrated Precipitable Water Aid Weather Forecasters; Integrating a Microwave Radiometer into Radar Hardware for Simultaneous Data Collection Between the Instruments; Rapid Detection of Herpes Viruses for Clinical Applications; High-Speed Data Recorder for Space, Geodesy, and Other High-Speed Recording Applications; Datacasting V3.0; An All-Solid-State, Room-Temperature, Heterodyne Receiver for Atmospheric Spectroscopy at 1.2 THz; Stacked Transformer for Driver Gain and Receive Signal Splitting; Wireless Integrated Microelectronic Vacuum Sensor System; Fabrication Method for LOBSTER-Eye Optics in <110> Silicon; Compact Focal Plane Assembly for Planetary Science; Fabrication Methods for Adaptive Deformable Mirrors; Visiting Vehicle Ground Trajectory Tool; Workflow-Based Software Development Environment; Mobile Thread Task Manager; A Kinematic Calibration Process for Flight Robotic Arms; Magnetostrictive Alternator; Bulk Metallic Glasses and Composites for Optical and Compliant Mechanisms; Detection of Only Viable Bacterial Spores Using a Live/Dead Indicator in Mixed Populations; and Intravenous Fluid Generation System.

Scope of Work for Integration Management and Installation Services of the National Ignition Facility Beampath Infrastructure System

DOE Office of Scientific and Technical Information (OSTI.GOV)

Coyle, P.D.

2000-04-25

The goal of the National Ignition Facility (NIF) project is to provide an aboveground experimental capability for maintaining nuclear competence and weapons effects simulation and to provide a facility capable of achieving fusion ignition using solid-state lasers as the energy driver. The facility will incorporate 192 laser beams, which will be focused onto a small target located at the center of a spherical target chamber--the energy from the laser beams will be deposited in a few billionths of a second. The target will then implode, forcing atomic nuclei to sufficiently high temperatures and densities necessary to achieve a miniature fusionmore » reaction. The NIF is under construction, at Livermore, California, located approximately 50 miles southeast of San Francisco, California.« less

Scope of Work for Integration Management and Installation Services of the National Ignition Facility Beampath Infrastructure System

DOE Office of Scientific and Technical Information (OSTI.GOV)

Coyle, P.D.

The goal of the National Ignition Facility (NIF) project is to provide an aboveground experimental capability for maintaining nuclear competence and weapons effects simulation and to provide a facility capable of achieving fusion ignition using solid-state lasers as the energy driver. The facility will incorporate 192 laser beams, which will be focused onto a small target located at the center of a spherical target chamber--the energy from the laser beams will be deposited in a few billionths of a second. The target will then implode, forcing atomic nuclei to sufficiently high temperatures and densities necessary to achieve a miniature fusionmore » reaction. The NIF is under construction, at Livermore, California, located approximately 50 miles southeast of San Francisco, California.« less

Detection of an ALK Fusion in Colorectal Carcinoma by Hybrid Capture-Based Assay of Circulating Tumor DNA.

PubMed

Lai, Andrea Z; Schrock, Alexa B; Erlich, Rachel L; Ross, Jeffrey S; Miller, Vincent A; Yakirevich, Evgeny; Ali, Siraj M; Braiteh, Fadi

2017-07-01

ALK rearrangements have been observed in 0.05%-2.5% of patients with colorectal cancers (CRCs) and are predicted to be oncogenic drivers largely mutually exclusive of KRAS, NRAS, or BRAF alterations. Here we present the case of a patient with metastatic CRC who was treatment naïve at the time of molecular testing. Initial ALK immunohistochemistry (IHC) staining was negative, but parallel genomic profiling of both circulating tumor DNA (ctDNA) and tissue using similar hybrid capture-based assays each identified an identical STRN-ALK fusion. Subsequent ALK IHC staining of the same specimens was positive, suggesting that the initial result was a false negative. This report is the first instance of an ALK fusion in CRC detected using a ctDNA assay. Current guidelines for colorectal cancer (CRC) only recommend genomic assessment of KRAS, NRAS, BRAF, and microsatellite instability (MSI) status. ALK rearrangements are rare in CRC, but patients with activating ALK fusions have responded to targeted therapies ALK rearrangements can be detected by genomic profiling of ctDNA from blood or tissue, and this methodology may be informative in cases where immunohistochemistry (IHC) or other standard testing is negative. © AlphaMed Press 2017.

Poloidal asymmetries in edge transport barriersa)

NASA Astrophysics Data System (ADS)

Churchill, R. M.; Theiler, C.; Lipschultz, B.; Hutchinson, I. H.; Reinke, M. L.; Whyte, D.; Hughes, J. W.; Catto, P.; Landreman, M.; Ernst, D.; Chang, C. S.; Hager, R.; Hubbard, A.; Ennever, P.; Walk, J. R.

2015-05-01

Measurements of impurities in Alcator C-Mod indicate that in the pedestal region, significant poloidal asymmetries can exist in the impurity density, ion temperature, and main ion density. In light of the observation that ion temperature and electrostatic potential are not constant on a flux surface [Theiler et al., Nucl. Fusion 54, 083017 (2014)], a technique based on total pressure conservation to align profiles measured at separate poloidal locations is presented and applied. Gyrokinetic neoclassical simulations with XGCa support the observed large poloidal variations in ion temperature and density, and that the total pressure is approximately constant on a flux surface. With the updated alignment technique, the observed in-out asymmetry in impurity density is reduced from previous publishing [Churchill et al., Nucl. Fusion 53, 122002 (2013)], but remains substantial ( n z , H / n z , L ˜ 6 ). Candidate asymmetry drivers are explored, showing that neither non-uniform impurity sources nor localized fluctuation-driven transport are able to explain satisfactorily the impurity density asymmetry. Since impurity density asymmetries are only present in plasmas with strong electron density gradients, and radial transport timescales become comparable to parallel transport timescales in the pedestal region, it is suggested that global transport effects relating to the strong electron density gradients in the pedestal are the main driver for the pedestal in-out impurity density asymmetry.

ROS1 and ALK Fusions in Colorectal Cancer, with Evidence of Intra-tumoral Heterogeneity for Molecular Drivers

PubMed Central

Aisner, Dara L.; Nguyen, Teresa T.; Paskulin, Diego D.; Le, Anh T.; Haney, Jerry; Schulte, Nathan; Chionh, Fiona; Hardingham, Jenny; Mariadason, John; Tebbutt, Niall; Doebele, Robert C.; Weickhardt, Andrew J.; Varella-Garcia, Marileila

2014-01-01

Activated ALK and ROS1 tyrosine kinases, through gene fusions, has been found in lung adenocarcinomas and are highly sensitive to selective kinase inhibitors. This study aimed at identifying the presence of these rearrangements in human colorectal adenocarcinoma (CRC) specimens using a 4-target, 4-color break-apart fluorescence in situ hybridization (FISH) assay to simultaneously determine the genomic status of ALK and ROS1. Among the clinical CRC specimens analyzed, rearrangement-positive cases for both ALK and ROS1 were observed. The fusion partner for ALK was identified as EML4 and the fusion partner for one of the ROS1-positive cases was SLC34A2, the partner for the other ROS1-positive case remains to be identified. A small fraction of specimens presented duplicated or clustered copies of native ALK and ROS1. In addition, rearrangements were detected in samples that also harbored KRAS and BRAF mutations in two of the three cases. Interestingly, the ALK-positive specimen displayed marked intra-tumoral heterogeneity and rearrangement was also identified in regions of high-grade dysplasia. Despite the additional oncogenic events and tumor heterogeneity observed, elucidation of the first cases of ROS1 rearrangements and confirmation of ALK rearrangements support further evaluation of these genomic fusions as potential therapeutic targets in CRC. Implications ROS1 and ALK fusions occur in colorectal cancer and may have substantial impact in therapy selection. PMID:24296758

Recurrent hyperactive ESR1 fusion proteins in endocrine therapy-resistant breast cancer.

PubMed

Hartmaier, R J; Trabucco, S E; Priedigkeit, N; Chung, J H; Parachoniak, C A; Vanden Borre, P; Morley, S; Rosenzweig, M; Gay, L M; Goldberg, M E; Suh, J; Ali, S M; Ross, J; Leyland-Jones, B; Young, B; Williams, C; Park, B; Tsai, M; Haley, B; Peguero, J; Callahan, R D; Sachelarie, I; Cho, J; Atkinson, J M; Bahreini, A; Nagle, A M; Puhalla, S L; Watters, R J; Erdogan-Yildirim, Z; Cao, L; Oesterreich, S; Mathew, A; Lucas, P C; Davidson, N E; Brufsky, A M; Frampton, G M; Stephens, P J; Chmielecki, J; Lee, A V

2018-04-01

Estrogen receptor-positive (ER-positive) metastatic breast cancer is often intractable due to endocrine therapy resistance. Although ESR1 promoter switching events have been associated with endocrine-therapy resistance, recurrent ESR1 fusion proteins have yet to be identified in advanced breast cancer. To identify genomic structural rearrangements (REs) including gene fusions in acquired resistance, we undertook a multimodal sequencing effort in three breast cancer patient cohorts: (i) mate-pair and/or RNAseq in 6 patient-matched primary-metastatic tumors and 51 metastases, (ii) high coverage (>500×) comprehensive genomic profiling of 287-395 cancer-related genes across 9542 solid tumors (5216 from metastatic disease), and (iii) ultra-high coverage (>5000×) genomic profiling of 62 cancer-related genes in 254 ctDNA samples. In addition to traditional gene fusion detection methods (i.e. discordant reads, split reads), ESR1 REs were detected from targeted sequencing data by applying a novel algorithm (copyshift) that identifies major copy number shifts at rearrangement hotspots. We identify 88 ESR1 REs across 83 unique patients with direct confirmation of 9 ESR1 fusion proteins (including 2 via immunoblot). ESR1 REs are highly enriched in ER-positive, metastatic disease and co-occur with known ESR1 missense alterations, suggestive of polyclonal resistance. Importantly, all fusions result from a breakpoint in or near ESR1 intron 6 and therefore lack an intact ligand binding domain (LBD). In vitro characterization of three fusions reveals ligand-independence and hyperactivity dependent upon the 3' partner gene. Our lower-bound estimate of ESR1 fusions is at least 1% of metastatic solid breast cancers, the prevalence in ctDNA is at least 10× enriched. We postulate this enrichment may represent secondary resistance to more aggressive endocrine therapies applied to patients with ESR1 LBD missense alterations. Collectively, these data indicate that N-terminal ESR1 fusions involving exons 6-7 are a recurrent driver of endocrine therapy resistance and are impervious to ER-targeted therapies.

Magnetic Linear Accelerator (MAGLAC) as Driver for Impact Fusion (IF)

DTIC Science & Technology

1979-07-01

qualitatively different. For example, a superconductor levitated by Meis- sner effect ("flux exculsion") would be vertically stable for z > a/2; an iron...These include, for example, 1. Further material research on superconductors under high magnetic field and high frequencies. 2. Theoretical and...DEFENSE PENTAGON IMSHJNGT0N5& 20301-7100 £?1C ^ALITY INSPECTED 4 This paper presents considerations on the design of a magnetic linear accelerator

Does assisted driving behavior lead to safety-critical encounters with unequipped vehicles' drivers?

PubMed

Preuk, Katharina; Stemmler, Eric; Schießl, Caroline; Jipp, Meike

2016-10-01

With Intelligent Transport Systems (e.g., traffic light assistance systems) assisted drivers are able to show driving behavior in anticipation of upcoming traffic situations. In the years to come, the penetration rate of such systems will be low. Therefore, the majority of vehicles will not be equipped with these systems. Unequipped vehicles' drivers may not expect the driving behavior of assisted drivers. However, drivers' predictions and expectations can play a significant role in their reaction times. Thus, safety issues could arise when unequipped vehicles' drivers encounter driving behavior of assisted drivers. This is why we tested how unequipped vehicles' drivers (N=60) interpreted and reacted to the driving behavior of an assisted driver. We used a multi-driver simulator with three drivers. The three drivers were driving in a line. The lead driver in the line was a confederate who was followed by two unequipped vehicles' drivers. We varied the equipment of the confederate with an Intelligent Transport System: The confederate was equipped either with or without a traffic light assistance system. The traffic light assistance system provided a start-up maneuver before a light turned green. Therefore, the assisted confederate seemed to show unusual deceleration behavior by coming to a halt at an unusual distance from the stop line at the red traffic light. The unusual distance was varied as we tested a moderate (4m distance from the stop line) and an extreme (10m distance from the stop line) parameterization of the system. Our results showed that the extreme parametrization resulted in shorter minimal time-to-collision of the unequipped vehicles' drivers. One rear-end crash was observed. These results provided initial evidence that safety issues can arise when unequipped vehicles' drivers encounter assisted driving behavior. We recommend that future research identifies counteractions to prevent these safety issues. Moreover, we recommend that system developers discuss the best parameterizations of their systems to ensure benefits but also the safety in encounters with unequipped vehicles' drivers. Copyright © 2016 Elsevier Ltd. All rights reserved.

CEP72-ROS1: A novel ROS1 oncogenic fusion variant in lung adenocarcinoma identified by next-generation sequencing.

PubMed

Zhu, You-Cai; Zhou, Yue-Fen; Wang, Wen-Xian; Xu, Chun-Wei; Zhuang, Wu; Du, Kai-Qi; Chen, Gang

2018-05-01

ROS1 rearrangement is a validated therapeutic driver gene in non-small cell lung cancer (NSCLC) and represents a small subset (1-2%) of NSCLC. A total of 17 different fusion partner genes of ROS1 in NSCLC have been reported. The multi-targeted MET/ALK/ROS1 tyrosine kinase inhibitor (TKI) crizotinib has demonstrated remarkable efficacy in ROS1-rearranged NSCLC. Consequently, ROS1 detection assays include fluorescence in situ hybridization, immunohistochemistry, and real-time PCR. Next-generation sequencing (NGS) assay covers a range of fusion genes and approaches to discover novel receptor-kinase rearrangements in lung cancer. A 63-year-old male smoker with stage IV NSCLC (TxNxM1) was detected with a novel ROS1 fusion. Histological examination of the tumor showed lung adenocarcinoma. NGS analysis of the hydrothorax cellblocks revealed a novel CEP72-ROS1 rearrangement. This novel CEP72-ROS1 fusion variant is generated by the fusion of exons 1-11 of CEP72 on chromosome 5p15 to exons 23-43 of ROS1 on chromosome 6q22. The predicted CEP72-ROS1 protein product contains 1202 amino acids comprising the N-terminal amino acids 594-647 of CEP72 and C-terminal amino acid 1-1148 of ROS1. CEP72-ROS1 is a novel ROS1 fusion variant in NSCLC discovered by NGS and could be included in ROS1 detection assay, such as reverse transcription PCR. Pleural effusion samples show good diagnostic performance in clinical practice. © 2018 The Authors. Thoracic Cancer published by China Lung Oncology Group and John Wiley & Sons Australia, Ltd.

CEP72‐ROS1: A novel ROS1 oncogenic fusion variant in lung adenocarcinoma identified by next‐generation sequencing

PubMed Central

Zhu, You‐cai; Zhou, Yue‐fen; Zhuang, Wu; Du, Kai‐qi; Chen, Gang

2018-01-01

ROS1 rearrangement is a validated therapeutic driver gene in non‐small cell lung cancer (NSCLC) and represents a small subset (1–2%) of NSCLC. A total of 17 different fusion partner genes of ROS1 in NSCLC have been reported. The multi‐targeted MET/ALK/ROS1 tyrosine kinase inhibitor (TKI) crizotinib has demonstrated remarkable efficacy in ROS1‐rearranged NSCLC. Consequently, ROS1 detection assays include fluorescence in situ hybridization, immunohistochemistry, and real‐time PCR. Next‐generation sequencing (NGS) assay covers a range of fusion genes and approaches to discover novel receptor‐kinase rearrangements in lung cancer. A 63‐year‐old male smoker with stage IV NSCLC (TxNxM1) was detected with a novel ROS1 fusion. Histological examination of the tumor showed lung adenocarcinoma. NGS analysis of the hydrothorax cellblocks revealed a novel CEP72‐ROS1 rearrangement. This novel CEP72‐ROS1 fusion variant is generated by the fusion of exons 1–11 of CEP72 on chromosome 5p15 to exons 23–43 of ROS1 on chromosome 6q22. The predicted CEP72‐ROS1 protein product contains 1202 amino acids comprising the N‐terminal amino acids 594–647 of CEP72 and C‐terminal amino acid 1‐1148 of ROS1. CEP72‐ROS1 is a novel ROS1 fusion variant in NSCLC discovered by NGS and could be included in ROS1 detection assay, such as reverse transcription PCR. Pleural effusion samples show good diagnostic performance in clinical practice. PMID:29517860

Biomechanics of coupled motion in the cervical spine during simulated whiplash in patients with pre-existing cervical or lumbar spinal fusion

PubMed Central

Huang, H.; Nightingale, R. W.

2018-01-01

Objectives Loss of motion following spine segment fusion results in increased strain in the adjacent motion segments. However, to date, studies on the biomechanics of the cervical spine have not assessed the role of coupled motions in the lumbar spine. Accordingly, we investigated the biomechanics of the cervical spine following cervical fusion and lumbar fusion during simulated whiplash using a whole-human finite element (FE) model to simulate coupled motions of the spine. Methods A previously validated FE model of the human body in the driver-occupant position was used to investigate cervical hyperextension injury. The cervical spine was subjected to simulated whiplash exposure in accordance with Euro NCAP (the European New Car Assessment Programme) testing using the whole human FE model. The coupled motions between the cervical spine and lumbar spine were assessed by evaluating the biomechanical effects of simulated cervical fusion and lumbar fusion. Results Peak anterior longitudinal ligament (ALL) strain ranged from 0.106 to 0.382 in a normal spine, and from 0.116 to 0.399 in a fused cervical spine. Strain increased from cranial to caudal levels. The mean strain increase in the motion segment immediately adjacent to the site of fusion from C2-C3 through C5-C6 was 26.1% and 50.8% following single- and two-level cervical fusion, respectively (p = 0.03, unpaired two-way t-test). Peak cervical strains following various lumbar-fusion procedures were 1.0% less than those seen in a healthy spine (p = 0.61, two-way ANOVA). Conclusion Cervical arthrodesis increases peak ALL strain in the adjacent motion segments. C3-4 experiences greater changes in strain than C6-7. Lumbar fusion did not have a significant effect on cervical spine strain. Cite this article: H. Huang, R. W. Nightingale, A. B. C. Dang. Biomechanics of coupled motion in the cervical spine during simulated whiplash in patients with pre-existing cervical or lumbar spinal fusion: A Finite Element Study. Bone Joint Res 2018;7:28–35. DOI: 10.1302/2046-3758.71.BJR-2017-0100.R1. PMID:29330341

Biomechanics of coupled motion in the cervical spine during simulated whiplash in patients with pre-existing cervical or lumbar spinal fusion: A Finite Element Study.

PubMed

Huang, H; Nightingale, R W; Dang, A B C

2018-01-01

Loss of motion following spine segment fusion results in increased strain in the adjacent motion segments. However, to date, studies on the biomechanics of the cervical spine have not assessed the role of coupled motions in the lumbar spine. Accordingly, we investigated the biomechanics of the cervical spine following cervical fusion and lumbar fusion during simulated whiplash using a whole-human finite element (FE) model to simulate coupled motions of the spine. A previously validated FE model of the human body in the driver-occupant position was used to investigate cervical hyperextension injury. The cervical spine was subjected to simulated whiplash exposure in accordance with Euro NCAP (the European New Car Assessment Programme) testing using the whole human FE model. The coupled motions between the cervical spine and lumbar spine were assessed by evaluating the biomechanical effects of simulated cervical fusion and lumbar fusion. Peak anterior longitudinal ligament (ALL) strain ranged from 0.106 to 0.382 in a normal spine, and from 0.116 to 0.399 in a fused cervical spine. Strain increased from cranial to caudal levels. The mean strain increase in the motion segment immediately adjacent to the site of fusion from C2-C3 through C5-C6 was 26.1% and 50.8% following single- and two-level cervical fusion, respectively (p = 0.03, unpaired two-way t -test). Peak cervical strains following various lumbar-fusion procedures were 1.0% less than those seen in a healthy spine (p = 0.61, two-way ANOVA). Cervical arthrodesis increases peak ALL strain in the adjacent motion segments. C3-4 experiences greater changes in strain than C6-7. Lumbar fusion did not have a significant effect on cervical spine strain. Cite this article : H. Huang, R. W. Nightingale, A. B. C. Dang. Biomechanics of coupled motion in the cervical spine during simulated whiplash in patients with pre-existing cervical or lumbar spinal fusion: A Finite Element Study. Bone Joint Res 2018;7:28-35. DOI: 10.1302/2046-3758.71.BJR-2017-0100.R1. © 2018 Huang et al.

Association of Graduated Driver Licensing With Driver, Non-Driver, and Total Fatalities Among Adolescents.

PubMed

Zhu, Motao; Zhao, Songzhu; Long, D Leann; Curry, Allison E

2016-07-01

Graduated driver licensing systems typically require an extended learner permit phase, and create night-time driving or passenger restrictions for adolescent drivers. Restricted driving might increase the use of alternative transportation to replace driving and consequently increase crashes and injuries for passengers, bus riders, pedestrians, and bicyclists. This study examined whether graduated driver licensing increases non-driver fatalities among adolescents, and whether it reduces total traffic fatalities combining drivers and non-drivers. Longitudinal analyses were conducted using data from the 1995-2012 U.S. Fatality Analysis Reporting System. Adjusted rate ratios were estimated for being fatally injured in a crash according to: (1) presence/absence of a graduated driver licensing system; and (2) four levels of graduated driver licensing systems (absent, weak, medium, strong). Analyses were conducted in 2015. Among adolescents aged 16 years, graduated driver licensing was not associated with increased passenger fatalities (adjusted rate ratio, 0.96; 95% CI=0.90, 1.03) or pedestrian and bicyclist fatalities (adjusted rate ratio, 1.09; 95% CI=0.85, 1.39), but was associated with an 11% reduction in total traffic fatalities. Among those aged 17 years, graduated driver licensing was not associated with increased fatalities as passengers, pedestrians, or bicyclists, and was not associated with reduced total traffic fatalities. In general, graduated driver licensing systems were not associated with increased fatalities as passengers, pedestrians, bicyclists, and bus riders. Graduated driver licensing systems were associated with reduced total fatalities of adolescents aged 16 years. Copyright © 2016 American Journal of Preventive Medicine. Published by Elsevier Inc. All rights reserved.

Development of 1D Liner Compression Code for IDL

NASA Astrophysics Data System (ADS)

Shimazu, Akihisa; Slough, John; Pancotti, Anthony

2015-11-01

A 1D liner compression code is developed to model liner implosion dynamics in the Inductively Driven Liner Experiment (IDL) where FRC plasmoid is compressed via inductively-driven metal liners. The driver circuit, magnetic field, joule heating, and liner dynamics calculations are performed at each time step in sequence to couple these effects in the code. To obtain more realistic magnetic field results for a given drive coil geometry, 2D and 3D effects are incorporated into the 1D field calculation through use of correction factor table lookup approach. Commercial low-frequency electromagnetic fields solver, ANSYS Maxwell 3D, is used to solve the magnetic field profile for static liner condition at various liner radius in order to derive correction factors for the 1D field calculation in the code. The liner dynamics results from the code is verified to be in good agreement with the results from commercial explicit dynamics solver, ANSYS Explicit Dynamics, and previous liner experiment. The developed code is used to optimize the capacitor bank and driver coil design for better energy transfer and coupling. FRC gain calculations are also performed using the liner compression data from the code for the conceptual design of the reactor sized system for fusion energy gains.

DNAJB1–PRKACA fusion kinase interacts with β-catenin and the liver regenerative response to drive fibrolamellar hepatocellular carcinoma

PubMed Central

Kastenhuber, Edward R.; Lalazar, Gadi; Houlihan, Shauna L.; Tschaharganeh, Darjus F.; Baslan, Timour; Chen, Chi-Chao; Requena, David; Tian, Sha; Bosbach, Benedikt; Wilkinson, John E.; Simon, Sanford M.; Lowe, Scott W.

2017-01-01

A segmental deletion resulting in DNAJB1–PRKACA gene fusion is now recognized as the signature genetic event of fibrolamellar hepatocellular carcinoma (FL-HCC), a rare but lethal liver cancer that primarily affects adolescents and young adults. Here we implement CRISPR-Cas9 genome editing and transposon-mediated somatic gene transfer to demonstrate that expression of either the endogenous fusion protein or a chimeric cDNA leads to the formation of indolent liver tumors in mice that closely resemble human FL-HCC. Notably, overexpression of the wild-type PRKACA was unable to fully recapitulate the oncogenic activity of DNAJB1–PRKACA, implying that FL-HCC does not simply result from enhanced PRKACA expression. Tumorigenesis was significantly enhanced by genetic activation of β-catenin, an observation supported by evidence of recurrent Wnt pathway mutations in human FL-HCC, as well as treatment with the hepatotoxin 3,5-diethoxycarbonyl-1,4-dihydrocollidine, which causes tissue injury, inflammation, and fibrosis. Our study validates the DNAJB1–PRKACA fusion kinase as an oncogenic driver and candidate drug target for FL-HCC, and establishes a practical model for preclinical studies to identify strategies to treat this disease. PMID:29162699

Simulation of the target creation through FRC merging for a magneto-inertial fusion concept

NASA Astrophysics Data System (ADS)

Li, Chenguang; Yang, Xianjun

2017-04-01

A two-dimensional magnetohydrodynamics model has been used to simulate the target creation process in a magneto-inertial fusion concept named Magnetized Plasma Fusion Reactor (MPFR) [C. Li and X. Yang, Phys. Plasmas 23, 102702 (2016)], where the target plasma created through Field reversed configuration (FRC) merging was compressed by an imploding liner driven by the pulsed-power driver. In the scheme, two initial FRCs (Field reversed configurations) are translated into the region where FRC merging occurs, bringing out the target plasma ready for compression. The simulations cover the three stages of the target creation process: formation, translation, and merging. The factors affecting the achieved target are analyzed numerically. The magnetic field gradient produced by the conical coils is found to determine how fast the FRC is accelerated to peak velocity and the collision merging occurs. Moreover, it is demonstrated that FRC merging can be realized by real coils with gaps showing nearly identical performance, and the optimized target by FRC merging shows larger internal energy and retained flux, which is more suitable for the MPFR concept.

The Nova Upgrade Facility for ICF ignition and gain

NASA Astrophysics Data System (ADS)

Lowdermilk, W. H.; Campbell, E. M.; Hunt, J. T.; Murray, J. R.; Storm, E.; Tobin, M. T.; Trenholme, J. B.

1992-01-01

Research on Inertial Confinement Fusion (ICF) is motivated by its potential defense and civilian applications, including ultimately the generation of electric power. The U.S. ICF Program was reviewed recently by the National Academy of Science (NAS) and the Fusion Policy Advisory Committee (FPAC). Both committees issued final reports in 1991 which recommended that first priority in the ICF program be placed on demonstrating fusion ignition and modest gain (G less than 10). The U.S. Department of Energy and Lawrence Livermore National Laboratory (LLNL) have proposed an upgrade of the existing Nova Laser Facility at LLNL to accomplish these goals. Both the NAS and FPAC have endorsed the upgrade of Nova as the optimal path to achieving ignition and gain. Results from Nova Upgrade Experiments will be used to define requirements for driver and target technology both for future high-yield military applications, such as the Laboratory Microfusion Facility (LMF) proposed by the Department of Energy, and for high-gain energy applications leading to an ICF engineering test facility. The central role and modifications which Nova Upgrade would play in the national ICF strategy are described.

Space charge tune shift, fast resonance traversal, and current limits in circular accelerators

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rees, G.H.

1996-06-01

Space charge tune shifts, fast resonance traversals, and current limits are important design issues for low energy, high power circular accelerators. Areas of interest are accumulator rings and fast cycling synchrotrons, and typical applications are for pulsed spallation neutron sources, heavy ion fusion storage ring drivers, and booster injectors for high energy proton and ion facilities. Aspects of the three topics are discussed in the paper. {copyright} {ital 1996 American Institute of Physics.}

Role and Mechanism of Structural Variation in Progression of Breast Cancer

DTIC Science & Technology

2013-09-01

mutations that occurred throughout tumor evolution, we identified 9 early nonsynonymous point mutations that occurred in cancer genes . Only five of...identified, are mutations in the TP53 gene suggesting its role as a driver mutation   5   • Our data also suggests that in the case of this one patient...generated by breakage-fusion- bridge cycles that promote repeated rounds of mutation within a chromosome arm, or from progressive amplification of genes that

Effects of automobile steering characteristics on driver vehicle system dynamics in regulation tasks

NASA Technical Reports Server (NTRS)

Mcruer, D. T.; Klein, R.

1975-01-01

A regulation task which subjected the automobile to a random gust disturbance which is countered by driver control action is used to study the effects of various automobile steering characteristics on the driver/vehicle system. The experiments used a variable stability automobile specially configured to permit insertion of the simulated gust disturbance and the measurement of the driver/vehicle system characteristics. Driver/vehicle system dynamics were measured and interpreted as an effective open loop system describing function. Objective measures of system bandwidth, stability, and time delays were deduced and compared. These objective measures were supplemented by driver ratings. A tentative optimum range of vehicle dynamics for the directional regulation task was established.

Automatic Railway Traffic Object Detection System Using Feature Fusion Refine Neural Network under Shunting Mode.

PubMed

Ye, Tao; Wang, Baocheng; Song, Ping; Li, Juan

2018-06-12

Many accidents happen under shunting mode when the speed of a train is below 45 km/h. In this mode, train attendants observe the railway condition ahead using the traditional manual method and tell the observation results to the driver in order to avoid danger. To address this problem, an automatic object detection system based on convolutional neural network (CNN) is proposed to detect objects ahead in shunting mode, which is called Feature Fusion Refine neural network (FR-Net). It consists of three connected modules, i.e., the depthwise-pointwise convolution, the coarse detection module, and the object detection module. Depth-wise-pointwise convolutions are used to improve the detection in real time. The coarse detection module coarsely refine the locations and sizes of prior anchors to provide better initialization for the subsequent module and also reduces search space for the classification, whereas the object detection module aims to regress accurate object locations and predict the class labels for the prior anchors. The experimental results on the railway traffic dataset show that FR-Net achieves 0.8953 mAP with 72.3 FPS performance on a machine with a GeForce GTX1080Ti with the input size of 320 × 320 pixels. The results imply that FR-Net takes a good tradeoff both on effectiveness and real time performance. The proposed method can meet the needs of practical application in shunting mode.

Engineering design of the PLX- α coaxial gun

NASA Astrophysics Data System (ADS)

Cruz, Edward; Brockington, Samuel; Case, Andrew; Luna, Marco; Witherspoon, Douglas; Langendorf, Samuel

2016-10-01

We describe the engineering and technical aspects of the coaxial gun designed for the 60-gun scaling study of spherically imploding plasma liners as a standoff driver for plasma-jet-driven magneto-inertial fusion. Each coaxial gun incorporates a fast, dense gas injection and triggering system, a compact low-weight pfn with integral sparkgap switching, and a contoured gap designed to suppress the blow-by instability. Alpha1 and Alpha2 guns are compared, with emphasis on the improvements on Alpha2, which include a faster more robust gas valve, an improved electrode contour, a custom 600- μF, 5-kV pfn, and a set of six inline sparkgap switches operated in parallel. The switch and pfn configurations are mounted directly to the back of the gun, and are designed to reduce inductance, cost, and complexity, maximize efficiency and system reliability, and ensure symmetric current flow. We will provide a detailed overview of the design choices made for the PLX- α coaxial gun. This work supported by the ARPA-E ALPHA Program.

Acoustic Levitation With One Driver

NASA Technical Reports Server (NTRS)

Wang, T. G.; Rudnick, I.; Elleman, D. D.; Stoneburner, J. D.

1985-01-01

Report discusses acoustic levitation in rectangular chamber using one driver mounted at corner. Placement of driver at corner enables it to couple effectively to acoustic modes along all three axes. Use of single driver reduces cost, complexity and weight of levitation system below those of three driver system.

A driver-adaptive stability control strategy for sport utility vehicles

NASA Astrophysics Data System (ADS)

Zhu, Shenjin; He, Yuping

2017-08-01

Conventional vehicle stability control (VSC) systems are designed for average drivers. For a driver with a good driving skill, the VSC systems may be redundant; for a driver with a poor driving skill, the VSC intervention may be inadequate. To increase safety of sport utility vehicles (SUVs), this paper proposes a novel driver-adaptive VSC (DAVSC) strategy based on scaling the target yaw rate commanded by the driver. The DAVSC system is adaptive to drivers' driving skills. More control effort would be exerted for drivers with poor driving skills, and vice versa. A sliding mode control (SMC)-based differential braking (DB) controller is designed using a three degrees of freedom (DOF) yaw-plane model. An eight DOF nonlinear yaw-roll model is used to simulate the SUV dynamics. Two driver models, namely longitudinal and lateral, are used to 'drive' the virtual SUV. By integrating the virtual SUV, the DB controller, and the driver models, the performance of the DAVSC system is investigated. The simulations demonstrate the effectiveness of the DAVSC strategy.

A novel framework of tissue membrane systems for image fusion.

PubMed

Zhang, Zulin; Yi, Xinzhong; Peng, Hong

2014-01-01

This paper proposes a tissue membrane system-based framework to deal with the optimal image fusion problem. A spatial domain fusion algorithm is given, and a tissue membrane system of multiple cells is used as its computing framework. Based on the multicellular structure and inherent communication mechanism of the tissue membrane system, an improved velocity-position model is developed. The performance of the fusion framework is studied with comparison of several traditional fusion methods as well as genetic algorithm (GA)-based and differential evolution (DE)-based spatial domain fusion methods. Experimental results show that the proposed fusion framework is superior or comparable to the other methods and can be efficiently used for image fusion.

Fusion-Driven Space Plane for Lunar Exploration

NASA Astrophysics Data System (ADS)

Kammash, T.; Cassenti, B.

A fusion hybrid reactor where the fusion component is the gasdynamic mirror (GDM) is proposed as the driver of a rocket that would allow a space vehicle of the size of Boeing 747 to travel to the moon in about one day. The energy produced by the reactor is induced by fusion neutrons that impinge on a thorium-232 blanket where they breed uranium-233 and simultane- ously burn it to produce power. For a vehicle of mass 500 metric tons (mT), the thrust required to accelerate it at 1 g is 5 MN, and the specific impulse, Isp, necessary to accelerate 90% of the launch mass to the escape velocity of 11,200 m/sec is found to be 10,182 seconds. For these propulsion parameters, the coolant mass flow rate would be 49 kg/sec. We note that the time it takes the launch mass, initially at rest and accelerated at 1g, to reach the escape velocity is 1,020 seconds. At the above noted rate, the total propellant mass is approximately 50 mT, which is about 10% of the launch mass, validating the Isp needed to accelerate the remainder to the escape velocity. If we assume that the trajectory to the moon is linear, and we account for the deceleration of the vehicle by the earth's gravitational force, and its acceleration by the moon's gravitational force, we can calculate the average velocity and the time it takes to reach the moon. We find that the travel time is about 1.66 days, which in this model is effectively the time for a fly-by. A more rigorous calculation using the restricted three body approach with the third body being the spacecraft, and allowing for a coordinate system that rotates at the circular frequency of the larger masses, shows that the transit time is about 0.65 days, which is comparable to the flight time between New York and Sidney, Australia.

Preliminary evaluation of the North Carolina graduated driver licensing system : effects on young driver crashes

DOT National Transportation Integrated Search

2000-07-01

In December 1997, North Carolina became the second state to enact a comprehensive Graduated Driver Licensing (GDL) system. The purpose of the GSL is to reduce young driver crashes by introducing beginning drivers to the full range of driving experien...

Assessing drivers' response during automated driver support system failures with non-driving tasks.

PubMed

Shen, Sijun; Neyens, David M

2017-06-01

With the increase in automated driver support systems, drivers are shifting from operating their vehicles to supervising their automation. As a result, it is important to understand how drivers interact with these automated systems and evaluate their effect on driver responses to safety critical events. This study aimed to identify how drivers responded when experiencing a safety critical event in automated vehicles while also engaged in non-driving tasks. In total 48 participants were included in this driving simulator study with two levels of automated driving: (a) driving with no automation and (b) driving with adaptive cruise control (ACC) and lane keeping (LK) systems engaged; and also two levels of a non-driving task (a) watching a movie or (b) no non-driving task. In addition to driving performance measures, non-driving task performance and the mean glance duration for the non-driving task were compared between the two levels of automated driving. Drivers using the automated systems responded worse than those manually driving in terms of reaction time, lane departure duration, and maximum steering wheel angle to an induced lane departure event. These results also found that non-driving tasks further impaired driver responses to a safety critical event in the automated system condition. In the automated driving condition, driver responses to the safety critical events were slower, especially when engaged in a non-driving task. Traditional driver performance variables may not necessarily effectively and accurately evaluate driver responses to events when supervising autonomous vehicle systems. Thus, it is important to develop and use appropriate variables to quantify drivers' performance under these conditions. Copyright © 2017 Elsevier Ltd and National Safety Council. All rights reserved.

Design of DroDeASys (Drowsy Detection and Alarming System)

NASA Astrophysics Data System (ADS)

Juvale, Hrishikesh B.; Mahajan, Anant S.; Bhagwat, Ashwin A.; Badiger, Vishal T.; Bhutkar, Ganesh D.; Dhabe, Priyadarshan S.; Dhore, Manikrao L.

The paper discusses the Drowsy Detection & Alarming System that has been developed, using a non-intrusive approach. The system is basically developed to detect drivers dozing at the wheel at night time driving. The system uses a small infra-red night vision camera that points directly towards the driver`s face and monitors the driver`s eyes in order to detect fatigue. In such a case when fatigue is detected, a warning signal is issued to alert the driver. This paper discusses the algorithms that have been used to detect drowsiness. The decision whether the driver is dozing or not is taken depending on whether the eyes are open for a specific number of frames. If the eyes are found to be closed for a certain number of consecutive frames then the driver is alerted with an alarm.

Microcontroller based driver alertness detection systems to detect drowsiness

NASA Astrophysics Data System (ADS)

Adenin, Hasibah; Zahari, Rahimi; Lim, Tiong Hoo

2018-04-01

The advancement of embedded system for detecting and preventing drowsiness in a vehicle is a major challenge for road traffic accident systems. To prevent drowsiness while driving, it is necessary to have an alert system that can detect a decline in driver concentration and send a signal to the driver. Studies have shown that traffc accidents usually occur when the driver is distracted while driving. In this paper, we have reviewed a number of detection systems to monitor the concentration of a car driver and propose a portable Driver Alertness Detection System (DADS) to determine the level of concentration of the driver based on pixelated coloration detection technique using facial recognition. A portable camera will be placed at the front visor to capture facial expression and the eye activities. We evaluate DADS using 26 participants and have achieved 100% detection rate with good lighting condition and a low detection rate at night.

Changing drivers' minds: the evaluation of an advanced driver coaching system.

PubMed

Stanton, N A; Walker, G H; Young, M S; Kazi, T; Salmon, P M

2007-08-01

This paper reports on the study of an advanced driver coaching system. The study distinguishes between different types of post-licensure programmes in order to explore a system based on a model of identifying and responding to hazards, called 'information, position, speed, gear and acceleration' (IPSGA). Previous literature has been sceptical about the benefits of advanced driver education; thus, the current study was designed to control for the effects of coaching drivers in the 'IPSGA' system (the treatment group) against the effects of being accompanied (control group 1), as well as the mere effects of time (control group 2). Measures were taken before the driver coaching began (as a baseline measure) and again after 8 weeks (to see if any changes had occurred). These measures included driver knowledge via a post-drive interview, observations of driving skill and driver attitude using a locus of control scale. The results suggest that advanced driver coaching using the IPSGA system had a beneficial effect on all of these measures. Drivers in the coaching condition improved their situation awareness, driving skills and reduced attributions of external locus of control. The study lends support to the case for one-to-one individualized driver coaching using a systematic model of driving.

A predictive control framework for torque-based steering assistance to improve safety in highway driving

NASA Astrophysics Data System (ADS)

Ercan, Ziya; Carvalho, Ashwin; Tseng, H. Eric; Gökaşan, Metin; Borrelli, Francesco

2018-05-01

Haptic shared control framework opens up new perspectives on the design and implementation of the driver steering assistance systems which provide torque feedback to the driver in order to improve safety. While designing such a system, it is important to account for the human-machine interactions since the driver feels the feedback torque through the hand wheel. The controller should consider the driver's impact on the steering dynamics to achieve a better performance in terms of driver's acceptance and comfort. In this paper we present a predictive control framework which uses a model of driver-in-the-loop steering dynamics to optimise the torque intervention with respect to the driver's neuromuscular response. We first validate the system in simulations to compare the performance of the controller in nominal and model mismatch cases. Then we implement the controller in a test vehicle and perform experiments with a human driver. The results show the effectiveness of the proposed system in avoiding hazardous situations under different driver behaviours.

Driver usage and understanding of adaptive cruise control.

PubMed

Larsson, Annika F L

2012-05-01

Automation, in terms of systems such as adaptive/active cruise control (ACC) or collision warning systems, is increasingly becoming a part of everyday driving. These systems are not perfect though, and the driver has to be prepared to reclaim control in situations very similar to those the system easily handles by itself. This paper uses a questionnaire answered by 130 ACC users to discuss future research needs in the area of driver assistance systems. Results show that the longer drivers use their systems, the more aware of its limitations they become. Moreover, the drivers report that ACC forces them to take control intermittently. According to theory, this might actually be better than a more perfect system, as it provides preparation for unexpected situations requiring the driver to reclaim control. Copyright © 2011 Elsevier Ltd and The Ergonomics Society. All rights reserved.

Calculations of Excitation Functions of Some Structural Fusion Materials for ( n, t) Reactions up to 50 MeV Energy

NASA Astrophysics Data System (ADS)

Tel, E.; Durgu, C.; Aktı, N. N.; Okuducu, Ş.

2010-06-01

Fusion serves an inexhaustible energy for humankind. Although there have been significant research and development studies on the inertial and magnetic fusion reactor technology, there is still a long way to go to penetrate commercial fusion reactors to the energy market. Tritium self-sufficiency must be maintained for a commercial power plant. For self-sustaining (D-T) fusion driver tritium breeding ratio should be greater than 1.05. So, the working out the systematics of ( n, t) reaction cross sections is of great importance for the definition of the excitation function character for the given reaction taking place on various nuclei at different energies. In this study, ( n, t) reactions for some structural fusion materials such as 27Al, 51V, 52Cr, 55Mn, and 56Fe have been investigated. The new calculations on the excitation functions of 27Al( n, t)25Mg, 51V( n, t)49Ti, 52Cr( n, t)50V, 55Mn( n, t)53Cr and 56Fe( n, t)54Mn reactions have been carried out up to 50 MeV incident neutron energy. In these calculations, the pre-equilibrium and equilibrium effects have been investigated. The pre-equilibrium calculations involve the new evaluated the geometry dependent hybrid model, hybrid model and the cascade exciton model. Equilibrium effects are calculated according to the Weisskopf-Ewing model. Also in the present work, we have calculated ( n, t) reaction cross-sections by using new evaluated semi-empirical formulas developed by Tel et al. at 14-15 MeV energy. The calculated results are discussed and compared with the experimental data taken from the literature.

Design of a multisensor data fusion system for target detection

NASA Astrophysics Data System (ADS)

Thomopoulos, Stelios C.; Okello, Nickens N.; Kadar, Ivan; Lovas, Louis A.

1993-09-01

The objective of this paper is to discuss the issues that are involved in the design of a multisensor fusion system and provide a systematic analysis and synthesis methodology for the design of the fusion system. The system under consideration consists of multifrequency (similar) radar sensors. However, the fusion design must be flexible to accommodate additional dissimilar sensors such as IR, EO, ESM, and Ladar. The motivation for the system design is the proof of the fusion concept for enhancing the detectability of small targets in clutter. In the context of down-selecting the proper configuration for multisensor (similar and dissimilar, and centralized vs. distributed) data fusion, the issues of data modeling, fusion approaches, and fusion architectures need to be addressed for the particular application being considered. Although the study of different approaches may proceed in parallel, the interplay among them is crucial in selecting a fusion configuration for a given application. The natural sequence for addressing the three different issues is to begin from the data modeling, in order to determine the information content of the data. This information will dictate the appropriate fusion approach. This, in turn, will lead to a global fusion architecture. Both distributed and centralized fusion architectures are used to illustrate the design issues along with Monte-Carlo simulation performance comparison of a single sensor versus a multisensor centrally fused system.

Homeland security application of the Army Soft Target Exploitation and Fusion (STEF) system

NASA Astrophysics Data System (ADS)

Antony, Richard T.; Karakowski, Joseph A.

2010-04-01

A fusion system that accommodates both text-based extracted information along with more conventional sensor-derived input has been developed and demonstrated in a terrorist attack scenario as part of the Empire Challenge (EC) 09 Exercise. Although the fusion system was developed to support Army military analysts, the system, based on a set of foundational fusion principles, has direct applicability to department of homeland security (DHS) & defense, law enforcement, and other applications. Several novel fusion technologies and applications were demonstrated in EC09. One such technology is location normalization that accommodates both fuzzy semantic expressions such as behind Library A, across the street from the market place, as well as traditional spatial representations. Additionally, the fusion system provides a range of fusion products not supported by traditional fusion algorithms. Many of these additional capabilities have direct applicability to DHS. A formal test of the fusion system was performed during the EC09 exercise. The system demonstrated that it was able to (1) automatically form tracks, (2) help analysts visualize behavior of individuals over time, (3) link key individuals based on both explicit message-based information as well as discovered (fusion-derived) implicit relationships, and (4) suggest possible individuals of interest based on their association with High Value Individuals (HVI) and user-defined key locations.

Recurrent hyperactive ESR1 fusion proteins in endocrine therapy-resistant breast cancer

PubMed Central

Trabucco, S E; Priedigkeit, N; Parachoniak, C A; Vanden Borre, P; Morley, S; Rosenzweig, M; Gay, L M; Goldberg, M E; Suh, J; Ali, S M; Ross, J; Leyland-Jones, B; Young, B; Williams, C; Park, B; Tsai, M; Haley, B; Peguero, J; Callahan, R D; Sachelarie, I; Cho, J; Atkinson, J M; Bahreini, A; Nagle, A M; Puhalla, S L; Watters, R J; Erdogan-Yildirim, Z; Cao, L; Oesterreich, S; Mathew, A; Lucas, P C; Davidson, N E; Brufsky, A M; Frampton, G M; Stephens, P J; Chmielecki, J; Lee, A V

2018-01-01

Abstract Background Estrogen receptor-positive (ER-positive) metastatic breast cancer is often intractable due to endocrine therapy resistance. Although ESR1 promoter switching events have been associated with endocrine-therapy resistance, recurrent ESR1 fusion proteins have yet to be identified in advanced breast cancer. Patients and methods To identify genomic structural rearrangements (REs) including gene fusions in acquired resistance, we undertook a multimodal sequencing effort in three breast cancer patient cohorts: (i) mate-pair and/or RNAseq in 6 patient-matched primary-metastatic tumors and 51 metastases, (ii) high coverage (>500×) comprehensive genomic profiling of 287–395 cancer-related genes across 9542 solid tumors (5216 from metastatic disease), and (iii) ultra-high coverage (>5000×) genomic profiling of 62 cancer-related genes in 254 ctDNA samples. In addition to traditional gene fusion detection methods (i.e. discordant reads, split reads), ESR1 REs were detected from targeted sequencing data by applying a novel algorithm (copyshift) that identifies major copy number shifts at rearrangement hotspots. Results We identify 88 ESR1 REs across 83 unique patients with direct confirmation of 9 ESR1 fusion proteins (including 2 via immunoblot). ESR1 REs are highly enriched in ER-positive, metastatic disease and co-occur with known ESR1 missense alterations, suggestive of polyclonal resistance. Importantly, all fusions result from a breakpoint in or near ESR1 intron 6 and therefore lack an intact ligand binding domain (LBD). In vitro characterization of three fusions reveals ligand-independence and hyperactivity dependent upon the 3′ partner gene. Our lower-bound estimate of ESR1 fusions is at least 1% of metastatic solid breast cancers, the prevalence in ctDNA is at least 10× enriched. We postulate this enrichment may represent secondary resistance to more aggressive endocrine therapies applied to patients with ESR1 LBD missense alterations. Conclusions Collectively, these data indicate that N-terminal ESR1 fusions involving exons 6–7 are a recurrent driver of endocrine therapy resistance and are impervious to ER-targeted therapies. PMID:29360925

Real time monitoring system used in route planning for the electric vehicle

NASA Astrophysics Data System (ADS)

Ionescu, LM; Mazare, A.; Serban, G.; Ionita, S.

2017-10-01

The electric vehicle is a new consumer of electricity that is becoming more and more widespread. Under these circumstances, new strategies for optimizing power consumption and increasing vehicle autonomy must be designed. These must include route planning along with consumption, fuelling points and points of interest. The hardware and software solution proposed by us allows: non-invasive monitoring of power consumption, energy autonomy - it does not add any extra consumption, data transmission to a server and data fusion with the route, the points of interest of the route and the power supply points. As a result: an optimal route planning service will be provided to the driver, considering the route, the requirements of the electric vehicle and the consumer profile. The solution can be easily installed on any type of electric car - it does not involve any intervention on the equipment.

Fusion or confusion: knowledge or nonsense?

NASA Astrophysics Data System (ADS)

Rothman, Peter L.; Denton, Richard V.

1991-08-01

The terms 'data fusion,' 'sensor fusion,' multi-sensor integration,' and 'multi-source integration' have been used widely in the technical literature to refer to a variety of techniques, technologies, systems, and applications which employ and/or combine data derived from multiple information sources. Applications of data fusion range from real-time fusion of sensor information for the navigation of mobile robots to the off-line fusion of both human and technical strategic intelligence data. The Department of Defense Critical Technologies Plan lists data fusion in the highest priority group of critical technologies, but just what is data fusion? The DoD Critical Technologies Plan states that data fusion involves 'the acquisition, integration, filtering, correlation, and synthesis of useful data from diverse sources for the purposes of situation/environment assessment, planning, detecting, verifying, diagnosing problems, aiding tactical and strategic decisions, and improving system performance and utility.' More simply states, sensor fusion refers to the combination of data from multiple sources to provide enhanced information quality and availability over that which is available from any individual source alone. This paper presents a survey of the state-of-the- art in data fusion technologies, system components, and applications. A set of characteristics which can be utilized to classify data fusion systems is presented. Additionally, a unifying mathematical and conceptual framework within which to understand and organize fusion technologies is described. A discussion of often overlooked issues in the development of sensor fusion systems is also presented.

Review of fusion synfuels

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fillo, J.A.

1980-01-01

Thermonuclear fusion offers an inexhaustible source of energy for the production of hydrogen from water. Depending on design, electric generation efficiencies of approx. 40 to 60% and hydrogen production efficiencies by high-temperature electrolysis of approx. 50 to 65% are projected for fusion reactors using high-temperatures blankets. Fusion/coal symbiotic systems appear economically promising for the first generation of commercial fusion synfuels plants. Coal production requirements and the environmental effects of large-scale coal usage would be greatly reduced by a fusion/coal system. In the long term, there could be a gradual transition to an inexhaustible energy system based solely on fusion.

[MRI/TRUS fusion-guided prostate biopsy : Value in the context of focal therapy].

PubMed

Franz, T; von Hardenberg, J; Blana, A; Cash, H; Baumunk, D; Salomon, G; Hadaschik, B; Henkel, T; Herrmann, J; Kahmann, F; Köhrmann, K-U; Köllermann, J; Kruck, S; Liehr, U-B; Machtens, S; Peters, I; Radtke, J P; Roosen, A; Schlemmer, H-P; Sentker, L; Wendler, J J; Witzsch, U; Stolzenburg, J-U; Schostak, M; Ganzer, R

2017-02-01

Several systems for MRI/TRUS fusion-guided biopsy of the prostate are commercially available. Many studies have shown superiority of fusion systems for tumor detection and diagnostic quality compared to random biopsy. The benefit of fusion systems in focal therapy of prostate cancer (PC) is less clear. Critical considerations of fusion systems for planning and monitoring of focal therapy of PC were investigated. A systematic literature review of available fusion systems for the period 2013-5/2016 was performed. A checklist of technical details, suitability for special anatomic situations and suitability for focal therapy was established by the German working group for focal therapy (Arbeitskreis fokale und Mikrotherapie). Eight fusion systems were considered (Artemis™, BioJet, BiopSee®, iSR´obot™ Mona Lisa, Hitachi HI-RVS, UroNav and Urostation®). Differences were found for biopsy mode (transrectal, perineal, both), fusion mode (elastic or rigid), navigation (image-based, electromagnetic sensor-based or mechanical sensor-based) and space requirements. Several consensus groups recommend fusion systems for focal therapy. Useful features are "needle tracking" and compatibility between fusion system and treatment device (available for Artemis™, BiopSee® and Urostation® with Focal One®; BiopSee®, Hitachi HI-RVS with NanoKnife®; BioJet, BiopSee® with cryoablation, brachytherapy). There are a few studies for treatment planning. However, studies on treatment monitoring after focal therapy are missing.

An Approach to Automated Fusion System Design and Adaptation

PubMed Central

Fritze, Alexander; Mönks, Uwe; Holst, Christoph-Alexander; Lohweg, Volker

2017-01-01

Industrial applications are in transition towards modular and flexible architectures that are capable of self-configuration and -optimisation. This is due to the demand of mass customisation and the increasing complexity of industrial systems. The conversion to modular systems is related to challenges in all disciplines. Consequently, diverse tasks such as information processing, extensive networking, or system monitoring using sensor and information fusion systems need to be reconsidered. The focus of this contribution is on distributed sensor and information fusion systems for system monitoring, which must reflect the increasing flexibility of fusion systems. This contribution thus proposes an approach, which relies on a network of self-descriptive intelligent sensor nodes, for the automatic design and update of sensor and information fusion systems. This article encompasses the fusion system configuration and adaptation as well as communication aspects. Manual interaction with the flexibly changing system is reduced to a minimum. PMID:28300762

An Approach to Automated Fusion System Design and Adaptation.

PubMed

Fritze, Alexander; Mönks, Uwe; Holst, Christoph-Alexander; Lohweg, Volker

2017-03-16

Industrial applications are in transition towards modular and flexible architectures that are capable of self-configuration and -optimisation. This is due to the demand of mass customisation and the increasing complexity of industrial systems. The conversion to modular systems is related to challenges in all disciplines. Consequently, diverse tasks such as information processing, extensive networking, or system monitoring using sensor and information fusion systems need to be reconsidered. The focus of this contribution is on distributed sensor and information fusion systems for system monitoring, which must reflect the increasing flexibility of fusion systems. This contribution thus proposes an approach, which relies on a network of self-descriptive intelligent sensor nodes, for the automatic design and update of sensor and information fusion systems. This article encompasses the fusion system configuration and adaptation as well as communication aspects. Manual interaction with the flexibly changing system is reduced to a minimum.

Driver-centred vehicle automation: using network analysis for agent-based modelling of the driver in highly automated driving systems.

PubMed

Banks, Victoria A; Stanton, Neville A

2016-11-01

To the average driver, the concept of automation in driving infers that they can become completely 'hands and feet free'. This is a common misconception, however, one that has been shown through the application of Network Analysis to new Cruise Assist technologies that may feature on our roads by 2020. Through the adoption of a Systems Theoretic approach, this paper introduces the concept of driver-initiated automation which reflects the role of the driver in highly automated driving systems. Using a combination of traditional task analysis and the application of quantitative network metrics, this agent-based modelling paper shows how the role of the driver remains an integral part of the driving system implicating the need for designers to ensure they are provided with the tools necessary to remain actively in-the-loop despite giving increasing opportunities to delegate their control to the automated subsystems. Practitioner Summary: This paper describes and analyses a driver-initiated command and control system of automation using representations afforded by task and social networks to understand how drivers remain actively involved in the task. A network analysis of different driver commands suggests that such a strategy does maintain the driver in the control loop.

Electromagnetic launchers

NASA Astrophysics Data System (ADS)

Kolm, H.; Mongeau, P.; Williams, F.

1980-09-01

Recent advances in energy storage, switching and magnet technology make electromagnetic acceleration a viable alternative to chemical propulsion for certain tasks, and a means to perform other tasks not previously feasible. Applications include the acceleration of gram-size particles for hypervelocity research and the initiation of fusion by impact, a replacement for chemically propelled artillery, the transportation of cargo and personnel over inaccessible terrain, and the launching of space vehicles to supply massive space operations, and for the disposal of nuclear waste. The simplest launcher of interest is the railgun, in which a short-circuit slide or an arc is driven along two rails by direct current. The most sophisticated studied thus far is the mass driver, in which a superconducting shuttle bucket is accelerated by a line of pulse coils energized by capacitors at energy conversion efficiencies better than 90%. Other accelerators of interest include helical, brush-commutated motors, discrete coil arc commutated drivers, flux compression momentum transformers, and various hybrid electrochemical devices.

Implementation of safety driving system using e-health and telematics technology.

PubMed

Lee, Youngbum; Lee, Myoungho

2008-08-01

This research aimed to develop a safety driving system using e-health and telematics technology. Biosignal sensors were installed in an automobile to check the driver's health status with an automatic diagnosis system providing health information to the driver. Measured data were sent to the e-health center through a telematics device, and a medical doctor analyzed these data, sending diagnosis and prescription information to the driver. This system recognizes the driver's sleeping, drinking impairment, excitability, and fatigue using biosensors. The system initially provides alerts in the automobile. It also controls the driving environment in the car, searches for a highway service area using Global Positioning System (GPS), and provides additional information for safety driving. If a car accident has occurred, it makes an emergency call to the nearest hospital, emergency center, and insurance company. A conceptual and prototype model for an imbedded system is presented with initial data for driver condition. Such a system could prevent car accidents caused by drivers driving while intoxicated and falling asleep at the wheel using the driver's biosignals measured by biosensors. The system can provide various e-health services using a telematics system to enhance the technical compatibility of the automobile.

A visual analytic framework for data fusion in investigative intelligence

NASA Astrophysics Data System (ADS)

Cai, Guoray; Gross, Geoff; Llinas, James; Hall, David

2014-05-01

Intelligence analysis depends on data fusion systems to provide capabilities of detecting and tracking important objects, events, and their relationships in connection to an analytical situation. However, automated data fusion technologies are not mature enough to offer reliable and trustworthy information for situation awareness. Given the trend of increasing sophistication of data fusion algorithms and loss of transparency in data fusion process, analysts are left out of the data fusion process cycle with little to no control and confidence on the data fusion outcome. Following the recent rethinking of data fusion as human-centered process, this paper proposes a conceptual framework towards developing alternative data fusion architecture. This idea is inspired by the recent advances in our understanding of human cognitive systems, the science of visual analytics, and the latest thinking about human-centered data fusion. Our conceptual framework is supported by an analysis of the limitation of existing fully automated data fusion systems where the effectiveness of important algorithmic decisions depend on the availability of expert knowledge or the knowledge of the analyst's mental state in an investigation. The success of this effort will result in next generation data fusion systems that can be better trusted while maintaining high throughput.

Generating High-Brightness Ion Beams for Inertial Confinement Fusion

NASA Astrophysics Data System (ADS)

Cuneo, M. E.

1997-11-01

The generation of high current density ion beams with applied-B ion diodes showed promise in the late-1980's as an efficient, rep-rate, focusable driver for inertial confinement fusion. These devices use several Tesla insulating magnetic fields to restrict electron motion across anode-cathode gaps of order 1-2 cm, while accelerating ions to generate ≈ 1 kA/cm^2, 5 - 15 MeV beams. These beams have been used to heat hohlraums to about 65 eV. However, meeting the ICF driver requirements for low-divergence and high-brightness lithium ion beams has been more technically challenging than initially thought. Experimental and theoretical work over the last 5 years shows that high-brightness beams meeting the requirements for inertial confinement fusion are possible. The production of these beams requires the simultaneous integration of at least four conditions: 1) rigorous vacuum cleaning techniques for control of undesired anode, cathode, ion source and limiter plasma formation from electrode contaminants to control impurity ions and impedance collapse; 2) carefully tailored insulating magnetic field geometry for uniform beam generation; 3) high magnetic fields (V_crit/V > 2) and other techniques to control the electron sheath and the onset of a high divergence electromagnetic instability that couples strongly to the ion beam; and 4) an active, pre-formed, uniform lithium plasma for low source divergence which is compatible with the above electron-sheath control techniques. These four conditions have never been simultaneously present in any lithium beam experiment, but simulations and experimental tests of individual conditions have been done. The integration of these conditions is a goal of the present ion beam generation program at Sandia. This talk will focus on the vacuum cleaning techniques for ion diodes and pulsed power devices in general, including experimental results obtained on the SABRE and PBFA-II accelerators over the last 3 years. The current status of integration of the other key physics and technologies required to demonstrate high-brightness ion beams will also be presented.

Assessing contextual factors that influence acceptance of pedestrian alerts by a night vision system.

PubMed

Källhammer, Jan-Erik; Smith, Kip

2012-08-01

We investigated five contextual variables that we hypothesized would influence driver acceptance of alerts to pedestrians issued by a night vision active safety system to inform the specification of the system's alerting strategies. Driver acceptance of automotive active safety systems is a key factor to promote their use and implies a need to assess factors influencing driver acceptance. In a field operational test, 10 drivers drove instrumented vehicles equipped with a preproduction night vision system with pedestrian detection software. In a follow-up experiment, the 10 drivers and 25 additional volunteers without experience with the system watched 57 clips with pedestrian encounters gathered during the field operational test. They rated the acceptance of an alert to each pedestrian encounter. Levels of rating concordance were significant between drivers who experienced the encounters and participants who did not. Two contextual variables, pedestrian location and motion, were found to influence ratings. Alerts were more accepted when pedestrians were close to or moving toward the vehicle's path. The study demonstrates the utility of using subjective driver acceptance ratings to inform the design of active safety systems and to leverage expensive field operational test data within the confines of the laboratory. The design of alerting strategies for active safety systems needs to heed the driver's contextual sensitivity to issued alerts.

Core conditions for alpha heating attained in direct-drive inertial confinement fusion

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bose, A.; Woo, K. M.; Betti, R.

It is shown that direct-drive implosions on the OMEGA laser have achieved core conditions that would lead to significant alpha heating at incident energies available on the National Ignition Facility (NIF) scale. The extrapolation of the experimental results from OMEGA to NIF energy assumes only that the implosion hydrodynamic efficiency is unchanged at higher energies. This approach is independent of the uncertainties in the physical mechanism that degrade implosions on OMEGA, and relies solely on a volumetric scaling of the experimentally observed core conditions. It is estimated that the current best-performing OMEGA implosion [Regan et al., Phys. Rev. Lett. 117,more » 025001 (2016)] extrapolated to a 1.9 MJ laser driver with the same illumination configuration and laser-target coupling would produce 125 kJ of fusion energy with similar levels of alpha heating observed in current highest performing indirect-drive NIF implosions.« less

Experiment to Form and Characterize a Section of a Spherically Imploding Plasma Liner

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hsu, S. C.; Langendorf, S. J.; Yates, K. C.

Here, we describe an experiment to form and characterize a section of a spherically imploding plasma liner by merging six supersonic plasma jets that are launched by newly designed contoured-gap coaxial plasma guns. This experiment is a prelude to forming a fully spherical imploding plasma liner using many dozens of plasma guns, as a standoff driver for plasma-jet-driven magneto-inertial fusion. The objectives of the six-jet experiments are to assess the evolution and scalings of liner Mach number and uniformity, which are important metrics for spherically imploding plasma liners to compress magnetized target plasmas to fusion conditions. Lastly, this article describesmore » the design of the coaxial plasma guns, experimental characterization of the plasma jets, six-jet experimental setup and diagnostics, initial diagnostic data from three- and six-jet experiments, and the high-level objectives of associated numerical modeling.« less

Experiment to Form and Characterize a Section of a Spherically Imploding Plasma Liner

DOE PAGES

Hsu, S. C.; Langendorf, S. J.; Yates, K. C.; ...

2017-12-18

Here, we describe an experiment to form and characterize a section of a spherically imploding plasma liner by merging six supersonic plasma jets that are launched by newly designed contoured-gap coaxial plasma guns. This experiment is a prelude to forming a fully spherical imploding plasma liner using many dozens of plasma guns, as a standoff driver for plasma-jet-driven magneto-inertial fusion. The objectives of the six-jet experiments are to assess the evolution and scalings of liner Mach number and uniformity, which are important metrics for spherically imploding plasma liners to compress magnetized target plasmas to fusion conditions. Lastly, this article describesmore » the design of the coaxial plasma guns, experimental characterization of the plasma jets, six-jet experimental setup and diagnostics, initial diagnostic data from three- and six-jet experiments, and the high-level objectives of associated numerical modeling.« less

Core conditions for alpha heating attained in direct-drive inertial confinement fusion

DOE PAGES

Bose, A.; Woo, K. M.; Betti, R.; ...

2016-07-07

It is shown that direct-drive implosions on the OMEGA laser have achieved core conditions that would lead to significant alpha heating at incident energies available on the National Ignition Facility (NIF) scale. The extrapolation of the experimental results from OMEGA to NIF energy assumes only that the implosion hydrodynamic efficiency is unchanged at higher energies. This approach is independent of the uncertainties in the physical mechanism that degrade implosions on OMEGA, and relies solely on a volumetric scaling of the experimentally observed core conditions. It is estimated that the current best-performing OMEGA implosion [Regan et al., Phys. Rev. Lett. 117,more » 025001 (2016)] extrapolated to a 1.9 MJ laser driver with the same illumination configuration and laser-target coupling would produce 125 kJ of fusion energy with similar levels of alpha heating observed in current highest performing indirect-drive NIF implosions.« less

Core conditions for alpha heating attained in direct-drive inertial confinement fusion.

PubMed

Bose, A; Woo, K M; Betti, R; Campbell, E M; Mangino, D; Christopherson, A R; McCrory, R L; Nora, R; Regan, S P; Goncharov, V N; Sangster, T C; Forrest, C J; Frenje, J; Gatu Johnson, M; Glebov, V Yu; Knauer, J P; Marshall, F J; Stoeckl, C; Theobald, W

2016-07-01

It is shown that direct-drive implosions on the OMEGA laser have achieved core conditions that would lead to significant alpha heating at incident energies available on the National Ignition Facility (NIF) scale. The extrapolation of the experimental results from OMEGA to NIF energy assumes only that the implosion hydrodynamic efficiency is unchanged at higher energies. This approach is independent of the uncertainties in the physical mechanism that degrade implosions on OMEGA, and relies solely on a volumetric scaling of the experimentally observed core conditions. It is estimated that the current best-performing OMEGA implosion [Regan et al., Phys. Rev. Lett. 117, 025001 (2016)10.1103/PhysRevLett.117.025001] extrapolated to a 1.9 MJ laser driver with the same illumination configuration and laser-target coupling would produce 125 kJ of fusion energy with similar levels of alpha heating observed in current highest performing indirect-drive NIF implosions.

Drivers' safety needs, behavioural adaptations and acceptance of new driving support systems.

PubMed

Saad, Farida; Van Elslande, Pierre

2012-01-01

The aim of this paper is to discuss the contribution of two complementary approaches for designing and evaluating new driver support systems likely to improve the operation and safety of the road traffic system. The first approach is based on detailed analyses of traffic crashes so as to estimate drivers' needs for assistance and the situational constraints that safety functions should address to be efficient. The second approach is based on in depth-analyses of behavioral adaptations induced by the usage of new driver support systems in regular driving situations and on drivers' acceptance of the assistance provided by the systems.

On the efficiency of driver state monitoring systems

NASA Astrophysics Data System (ADS)

Dementienko, V. V.; Dorokhov, V. B.; Gerus, S. V.; Markov, A. G.; Shakhnarovich, V. M.

2007-06-01

Statistical data on road traffic and the results of laboratory studies are used to construct a mathematical model of a driver-driver state monitor-automobile-traffic system. In terms of the model, the probability of an accident resulting from the drowsy state of the driver is determined both in the absence and presence of a monitor. The model takes into account the efficiency and safety level provided by different monitoring systems, as well as psychological factors associated with the excessive reliance of drivers upon monitoring.

PREFACE: The fifth International Conference on Inertial Fusion Sciences and Applications (IFSA2007)

NASA Astrophysics Data System (ADS)

Azechi, Hiroshi; Hammel, Bruce; Gauthier, Jean-Claude

2008-06-01

The Fifth International Conference on Inertial Fusion Sciences and Applications (IFSA 2007) was held on 9-14 September 2007 at Kobe International Conference Center in Kobe, Japan. The host organizations for this conference were Osaka University and the Institute of Laser Engineering (ILE) at Osaka University; and co-organized by the Institute Lasers and Plasmas (ILP) in France, the Commissariatá l'Energie Atomique (CEA), Lawrence Livermore National Laboratory (LLNL), National Institute for Fusion Science (NIFS) in Japan, and Kansai Photon Science Institute (KPSI), Japan Atomic Energy Agency (JAEA). The conference objective was to review the state of the art of research in inertial fusion sciences and applications since the last conference held in Biarritz, France, in 2005. 470 abstracts were accepted, and 448 persons from 18 countries attended the conference. These Proceedings contain 287 of the papers presented at IFSA 2007. This collection of papers represents the manuscripts submitted to and passing the peer review process. The program was organized with some specific features: The reviews of influential programs appeared both at the very beginning and at the very end of the Conference to attract attendance throughout the Conference. Each poster session had the same time period as a single oral session, thereby avoiding overlap with oral talks. The everyday program was structured to be as similar as possible so the attendees could easily recognize the program. With a goal of achieving inertial fusion ignition and burn propagation in the laboratory, researchers presented the exciting advances in both traditional hot spot ignition and fast ignition approach, including status report of USA's National Ignition Facility (NIF), French Laser Magajoule (LMJ), Japanese Fast Ignition Realization Experiment (FIREX), and European High Power laser Energy Research (HiPER). A particular emphasis of the meeting was that the `physics of inertial fusion' category was dominated by fast-ignition and related ultra-intense laser interaction. Progress in direct drive over the past few years resulted in the achievement of high-density cryogenic implosions at OMEGA. Continuous progresses in hohlraum physics gave confidence in the achievement of ignition at NIF and LMJ. Advances in Z-pinch included double-hohlraum irradiation symmetry and the PW laser beam for the Z-facility. Progress of laser material development for IFE driver was a very interesting topic of inertial fusion energy drivers, including KrF and DPSSL lasers and particle beams. Of special interest, a future session was focused on strategy of inertial fusion energy development. Laboratory tours were held in the middle of the Conference. The Laser for Fusion EXperiments (LFEX), a new high-energy petawatt laser at ILE, was one of the key attractions of IFSA 2007. 83 participants toured LFEX and GEKKO XII lasers, and 35 joined a tour of KPSA-JAEA. In parallel to the tour, the `Symposium on Academics-Industries Cooperation for Applications of High-Power Lasers' was held with more than 90 participants mostly from the industrial community. These Proceedings start with special chapters on the keynote and focus speeches and the Teller lectures. The keynotes and focus give an overview of progress in inertial fusion in Asia, North America, and Europe. The Teller lectures show the contributions of this year's two winners: Brian Thomas of AWE, UK and Kunioki Mima of ILE. The remainder of the Proceedings is divided into three parts. Part A covers the physics of inertial fusion; Part B covers laser, particle beams, and fusion technology including IFE reactors and target fabrication; and Part C covers science and technology applications such as laboratory astrophysics, laser particle acceleration, x-ray and EUV sources, and new applications of intense lasers. These parts are further divided into chapters covering specific areas of science or technology. Within each chapter the talks relevant to that subject are gathered. The IFSA International Organizing Committee and Scientific Advisory Board appreciate the efforts of inertial fusion researchers worldwide in making IFSA 2007 an extremely successful conference. The proceedings were published with the support of Dr Y Sakawa, Dr H Homma, Ms S Karasuyama, Ms M Odagiri, and Ms I Kobatake. Kunioki Mima Co-chair Hiroshi Azechi Technical Program Committee Co-chair John Lindl Co-chair Bruce Hammel Technical Program Committee Co-chair Christine Labaune Co-chair Jean-Claude Gauthier Technical Program Committee Co-chair

Human Factors Design Of Automated Highway Systems: Scenario Definition

DOT National Transportation Integrated Search

1995-09-01

Attention to driver acceptance and performance issues during system design will be key to the success of the Automated Highway System (AHS). A first step in the process of defining driver roles and driver-system interface requirements of AHS is the d...

HIP1-ALK, a novel ALK fusion variant that responds to crizotinib.

PubMed

Fang, Douglas D; Zhang, Bin; Gu, Qingyang; Lira, Maruja; Xu, Qiang; Sun, Hongye; Qian, Maoxiang; Sheng, Weiqi; Ozeck, Mark; Wang, Zhenxiong; Zhang, Cathy; Chen, Xinsheng; Chen, Kevin X; Li, Jian; Chen, Shu-Hui; Christensen, James; Mao, Mao; Chan, Chi-Chung

2014-03-01

The aim of this study was to identify anaplastic lymphoma kinase (ALK) rearrangements in lung cancer patient-derived xenograft (PDX) models and to explore their responses to crizotinib. Screening of 99 lung cancer PDX models by the NanoString ALK fusion assay identified two ALK-rearranged non-small-cell lung cancer (NSCLC) tumors, including one harboring a previously known echinoderm microtubule-associated protein-like 4 (EML4)-ALK fusion and another containing an unknown ALK fusion variant. Expression array, RNA-Seq, reverse transcription polymerase chain reaction, and direct sequencing were then conducted to confirm the rearrangements and to identify the novel fusion partner in the xenograft and/or the primary patient tumor. Finally, pharmacological studies were performed in PDX models to evaluate their responses to ALK inhibitor crizotinib. Two ALK-rearranged NSCLC PDX models were identified: one carried a well-known EML4-ALK variant 3a/b and the other harbored a novel huntingtin interacting protein 1 (HIP1)-ALK fusion gene. Exon 28 of the HIP1 gene located on chromosome 7 was fused to exon 20 of the ALK gene located on chromosome 2. Both cases were clinically diagnosed as squamous cell carcinoma. Compared with the other lung cancer PDX models, both ALK-rearranged models displayed elevated ALK mRNA expression. Furthermore, in vivo efficacy studies demonstrated that, similar to the EML4-ALK-positive model, the HIP1-ALK-containing PDX model was sensitive to treatment with crizotinib. Discovery of HIP1 as a fusion partner of ALK in NSCLC is a novel finding. In addition, the HIP1-ALK-rearranged tumor is sensitive to treatment with crizotinib in vivo, implicating HIP1-ALKas an oncogenic driver of lung tumorigenesis. Collectively, our results indicate that HIP1-ALK-positive NSCLC may benefit from clinical applications of crizotinib.

Scope of Work for Integration Management and Installation Services of the National Ignition Facility Beampath Infrastructure System

NASA Astrophysics Data System (ADS)

Coyle, P. D.

2000-03-01

The goal of the National Ignition Facility (NIF) project is to provide an above ground experimental capability for maintaining nuclear competence and weapons effects simulation and to provide a facility capable of achieving fusion ignition using solid-state lasers as the energy driver. The facility will incorporate 192 laser beams, which will be focused onto a small target located at the center of a spherical target chamber-the energy from the laser beams will be deposited in a few billionths of a second. The target will then implode, forcing atomic nuclei to sufficiently high temperatures and densities necessary to achieve a miniature fusion reaction. The NIF is under construction, at Livermore, California, located approximately 50 miles southeast of San Francisco, California. The University of California, Lawrence Livermore National Laboratory (LLNL), operating under Prime Contract W-7405-ENG. 48 with the U.S. Department of Energy (DOE), shall subcontract for Integration Management and Installation (IMI) Services for the Beampath Infrastructure System (BIS). The BIS includes Beampath Hardware and Beampath Utilities. Conventional Facilities work for the NIF Laser and Target Area Building (LTAB) and Optics Assembly Building (OAB) is over 86 percent constructed. This Scope of Work is for Integration Management and Installation (IMI) Services corresponding to Management Services, Design Integration Services, Construction Services, and Commissioning Services for the NIB BIS. The BIS includes Beampath Hardware and Beampath Utilities. Beampath Hardware and Beampath Utilities include beampath vessels, enclosures, and beam tubes; auxiliary and utility systems; and support structures. A substantial amount of GFE will be provided by the University for installation as part of the infrastructure packages.

Using Self-Reliance Factors to Decide How to Share Control Between Human Powered Wheelchair Drivers and Ultrasonic Sensors.

PubMed

Sanders, David A

2017-08-01

A shared-control scheme for a powered wheelchair is presented. The wheelchair can be operated by a wheelchair driver using a joystick, or directed by a sensor system, or control can be combined between them. The wheelchair system can modify direction depending on the local environment. Sharing the control allows a disabled wheelchair driver to drive safely and efficiently. The controller automatically establishes the control gains for the sensor system and the human driver by calculating a self-reliance factor for the wheelchair driver. The sensor system can influence the motion of the wheelchair to compensate for some deficiency in a disabled driver. Practical tests validate the proposed techniques and designs.

Human Factors in the Automated Highway System: Transferring Control to the Driver

DOT National Transportation Integrated Search

1995-10-01

Driver capabilities and limitations must be considered to ensure successful implementation of the Automated Highway System (AHS). Human factors investigations of driver performance characteristics provide the basis for determining system design confi...

Contributing Factors to Driver's Over-trust in a Driving Support System for Workload Reduction

NASA Astrophysics Data System (ADS)

Itoh, Makoto

Avoiding over-trust in machines is a vital issue in order to establish intelligent driver support systems. It is necessary to distinguish systems for workload reduction from systems for accident prevention/mitigation. This study focuses on over-trust in an Adaptive Cruise Control (ACC) system as a typical driving support system for workload reduction. By conducting an experiment, we obtained a case in which a driver trusted the ACC system too much. Concretely speaking, the driver just watched the ACC system crashing into a stopped car even though the ACC system was designed to ignore such stopped cars. This paper investigates possible contributing factors to the driver' s over-trust in the ACC system. The results suggest that emerging trust in the dimension of performance may cause over-trust in the dimension of method or purpose.

Prevalence of driver physical factors leading to unintentional lane departure crashes.

PubMed

Cicchino, Jessica B; Zuby, David S

2017-07-04

Some lane-keeping assist systems in development and production provide autonomous braking and steering to correct unintentional lane drift but otherwise require drivers to fully control their vehicles. The goal of this study was to quantify the proportion of drivers involved in unintentional lane drift crashes who would be unable to regain control of their vehicles to inform the design of such systems. The NHTSA's National Motor Vehicle Crash Causation Survey collected in-depth, on-scene data for a nationally representative sample of 5,470 U.S. police-reported passenger vehicle crashes during 2005-2007 that occurred between 6 a.m. and midnight and for which emergency medical services were dispatched. The physical states of drivers involved in the 631 lane drift crashes in the sample, which represented 259,034 crashes nationally, were characterized. Thirty-four percent of drivers who crashed because they drifted from their lanes were sleeping or otherwise incapacitated. These drivers would be unlikely to regain full control of their vehicles if an active safety system prevented their initial drift. An additional 13% of these drivers had a nonincapacitating medical issue, blood alcohol concentration (BAC) ≥ 0.08%, or other physical factor that may not allow them to regain full vehicle control. When crashes involved serious or fatal injuries, 42% of drivers who drifted were sleeping or otherwise incapacitated, and an additional 14% were impacted by a nonincapacitating medical issue, BAC ≥ 0.08%, or other physical factor. Designers of active safety systems that provide autonomous lateral control should consider that a substantial proportion of drivers at risk of lane drift crashes are incapacitated. Systems that provide only transient corrective action may not ultimately prevent lane departure crashes for these drivers, and drivers who do avoid lane drift crashes because of these systems may be at high risk of other types of crashes when they attempt to regain control. Active lane-keeping assist systems may need to be combined with in-vehicle driver monitoring to identify incapacitated drivers and safely remove them from the roadway if the systems are to reach their maximum potential benefit.

Feature and Score Fusion Based Multiple Classifier Selection for Iris Recognition

PubMed Central

Islam, Md. Rabiul

2014-01-01

The aim of this work is to propose a new feature and score fusion based iris recognition approach where voting method on Multiple Classifier Selection technique has been applied. Four Discrete Hidden Markov Model classifiers output, that is, left iris based unimodal system, right iris based unimodal system, left-right iris feature fusion based multimodal system, and left-right iris likelihood ratio score fusion based multimodal system, is combined using voting method to achieve the final recognition result. CASIA-IrisV4 database has been used to measure the performance of the proposed system with various dimensions. Experimental results show the versatility of the proposed system of four different classifiers with various dimensions. Finally, recognition accuracy of the proposed system has been compared with existing N hamming distance score fusion approach proposed by Ma et al., log-likelihood ratio score fusion approach proposed by Schmid et al., and single level feature fusion approach proposed by Hollingsworth et al. PMID:25114676

Feature and score fusion based multiple classifier selection for iris recognition.

PubMed

Islam, Md Rabiul

2014-01-01

The aim of this work is to propose a new feature and score fusion based iris recognition approach where voting method on Multiple Classifier Selection technique has been applied. Four Discrete Hidden Markov Model classifiers output, that is, left iris based unimodal system, right iris based unimodal system, left-right iris feature fusion based multimodal system, and left-right iris likelihood ratio score fusion based multimodal system, is combined using voting method to achieve the final recognition result. CASIA-IrisV4 database has been used to measure the performance of the proposed system with various dimensions. Experimental results show the versatility of the proposed system of four different classifiers with various dimensions. Finally, recognition accuracy of the proposed system has been compared with existing N hamming distance score fusion approach proposed by Ma et al., log-likelihood ratio score fusion approach proposed by Schmid et al., and single level feature fusion approach proposed by Hollingsworth et al.

Reduction of low frequency vibration of truck driver and seating system through system parameter identification, sensitivity analysis and active control

NASA Astrophysics Data System (ADS)

Wang, Xu; Bi, Fengrong; Du, Haiping

2018-05-01

This paper aims to develop an 5-degree-of-freedom driver and seating system model for optimal vibration control. A new method for identification of the driver seating system parameters from experimental vibration measurement has been developed. The parameter sensitivity analysis has been conducted considering the random excitation frequency and system parameter uncertainty. The most and least sensitive system parameters for the transmissibility ratio have been identified. The optimised PID controllers have been developed to reduce the driver's body vibration.

Detection scheme for a partially occluded pedestrian based on occluded depth in lidar-radar sensor fusion

NASA Astrophysics Data System (ADS)

Kwon, Seong Kyung; Hyun, Eugin; Lee, Jin-Hee; Lee, Jonghun; Son, Sang Hyuk

2017-11-01

Object detections are critical technologies for the safety of pedestrians and drivers in autonomous vehicles. Above all, occluded pedestrian detection is still a challenging topic. We propose a new detection scheme for occluded pedestrian detection by means of lidar-radar sensor fusion. In the proposed method, the lidar and radar regions of interest (RoIs) have been selected based on the respective sensor measurement. Occluded depth is a new means to determine whether an occluded target exists or not. The occluded depth is a region projected out by expanding the longitudinal distance with maintaining the angle formed by the outermost two end points of the lidar RoI. The occlusion RoI is the overlapped region made by superimposing the radar RoI and the occluded depth. The object within the occlusion RoI is detected by the radar measurement information and the occluded object is estimated as a pedestrian based on human Doppler distribution. Additionally, various experiments are performed in detecting a partially occluded pedestrian in outdoor as well as indoor environments. According to experimental results, the proposed sensor fusion scheme has much better detection performance compared to the case without our proposed method.

Comprehensive tire-road friction coefficient estimation based on signal fusion method under complex maneuvering operations

NASA Astrophysics Data System (ADS)

Li, L.; Yang, K.; Jia, G.; Ran, X.; Song, J.; Han, Z.-Q.

2015-05-01

The accurate estimation of the tire-road friction coefficient plays a significant role in the vehicle dynamics control. The estimation method should be timely and reliable for the controlling requirements, which means the contact friction characteristics between the tire and the road should be recognized before the interference to ensure the safety of the driver and passengers from drifting and losing control. In addition, the estimation method should be stable and feasible for complex maneuvering operations to guarantee the control performance as well. A signal fusion method combining the available signals to estimate the road friction is suggested in this paper on the basis of the estimated ones of braking, driving and steering conditions individually. Through the input characteristics and the states of the vehicle and tires from sensors the maneuvering condition may be recognized, by which the certainty factors of the friction of the three conditions mentioned above may be obtained correspondingly, and then the comprehensive road friction may be calculated. Experimental vehicle tests validate the effectiveness of the proposed method through complex maneuvering operations; the estimated road friction coefficient based on the signal fusion method is relatively timely and accurate to satisfy the control demands.

AxiaLIF system: minimally invasive device for presacral lumbar interbody spinal fusion

PubMed Central

Rapp, Steven M; Miller, Larry E; Block, Jon E

2011-01-01

Lumbar fusion is commonly performed to alleviate chronic low back and leg pain secondary to disc degeneration, spondylolisthesis with or without concomitant lumbar spinal stenosis, or chronic lumbar instability. However, the risk of iatrogenic injury during traditional anterior, posterior, and transforaminal open fusion surgery is significant. The axial lumbar interbody fusion (AxiaLIF) system is a minimally invasive fusion device that accesses the lumbar (L4–S1) intervertebral disc spaces via a reproducible presacral approach that avoids critical neurovascular and musculoligamentous structures. Since the AxiaLIF system received marketing clearance from the US Food and Drug Administration in 2004, clinical studies of this device have reported high fusion rates without implant subsidence, significant improvements in pain and function, and low complication rates. This paper describes the design and approach of this lumbar fusion system, details the indications for use, and summarizes the clinical experience with the AxiaLIF system to date. PMID:22915939

AxiaLIF system: minimally invasive device for presacral lumbar interbody spinal fusion.

PubMed

Rapp, Steven M; Miller, Larry E; Block, Jon E

2011-01-01

Lumbar fusion is commonly performed to alleviate chronic low back and leg pain secondary to disc degeneration, spondylolisthesis with or without concomitant lumbar spinal stenosis, or chronic lumbar instability. However, the risk of iatrogenic injury during traditional anterior, posterior, and transforaminal open fusion surgery is significant. The axial lumbar interbody fusion (AxiaLIF) system is a minimally invasive fusion device that accesses the lumbar (L4-S1) intervertebral disc spaces via a reproducible presacral approach that avoids critical neurovascular and musculoligamentous structures. Since the AxiaLIF system received marketing clearance from the US Food and Drug Administration in 2004, clinical studies of this device have reported high fusion rates without implant subsidence, significant improvements in pain and function, and low complication rates. This paper describes the design and approach of this lumbar fusion system, details the indications for use, and summarizes the clinical experience with the AxiaLIF system to date.

A dual-channel fusion system of visual and infrared images based on color transfer

NASA Astrophysics Data System (ADS)

Pei, Chuang; Jiang, Xiao-yu; Zhang, Peng-wei; Liang, Hao-cong

2013-09-01

A dual-channel fusion system of visual and infrared images based on color transfer The increasing availability and deployment of imaging sensors operating in multiple spectrums has led to a large research effort in image fusion, resulting in a plethora of pixel-level image fusion algorithms. However, most of these algorithms have gray or false color fusion results which are not adapt to human vision. Transfer color from a day-time reference image to get natural color fusion result is an effective way to solve this problem, but the computation cost of color transfer is expensive and can't meet the request of real-time image processing. We developed a dual-channel infrared and visual images fusion system based on TMS320DM642 digital signal processing chip. The system is divided into image acquisition and registration unit, image fusion processing unit, system control unit and image fusion result out-put unit. The image registration of dual-channel images is realized by combining hardware and software methods in the system. False color image fusion algorithm in RGB color space is used to get R-G fused image, then the system chooses a reference image to transfer color to the fusion result. A color lookup table based on statistical properties of images is proposed to solve the complexity computation problem in color transfer. The mapping calculation between the standard lookup table and the improved color lookup table is simple and only once for a fixed scene. The real-time fusion and natural colorization of infrared and visual images are realized by this system. The experimental result shows that the color-transferred images have a natural color perception to human eyes, and can highlight the targets effectively with clear background details. Human observers with this system will be able to interpret the image better and faster, thereby improving situational awareness and reducing target detection time.

Feasibility study on sensor data fusion for the CP-140 aircraft: fusion architecture analyses

NASA Astrophysics Data System (ADS)

Shahbazian, Elisa

1995-09-01

Loral Canada completed (May 1995) a Department of National Defense (DND) Chief of Research and Development (CRAD) contract, to study the feasibility of implementing a multi- sensor data fusion (MSDF) system onboard the CP-140 Aurora aircraft. This system is expected to fuse data from: (a) attributed measurement oriented sensors (ESM, IFF, etc.); (b) imaging sensors (FLIR, SAR, etc.); (c) tracking sensors (radar, acoustics, etc.); (d) data from remote platforms (data links); and (e) non-sensor data (intelligence reports, environmental data, visual sightings, encyclopedic data, etc.). Based on purely theoretical considerations a central-level fusion architecture will lead to a higher performance fusion system. However, there are a number of systems and fusion architecture issues involving fusion of such dissimilar data: (1) the currently existing sensors are not designed to provide the type of data required by a fusion system; (2) the different types (attribute, imaging, tracking, etc.) of data may require different degree of processing, before they can be used within a fusion system efficiently; (3) the data quality from different sensors, and more importantly from remote platforms via the data links must be taken into account before fusing; and (4) the non-sensor data may impose specific requirements on the fusion architecture (e.g. variable weight/priority for the data from different sensors). This paper presents the analyses performed for the selection of the fusion architecture for the enhanced sensor suite planned for the CP-140 aircraft in the context of the mission requirements and environmental conditions.

Developments for Personalized Medicine of Lung Cancer Subtypes: Mass Spectrometry-Based Clinical Proteogenomic Analysis of Oncogenic Mutations.

PubMed

Nishimura, Toshihide; Nakamura, Haruhiko

2016-01-01

Molecular therapies targeting lung cancers with mutated epidermal growth factor receptor (EGFR) by EGFR-tyrosin kinase inhibitors (EGFR-TKIs), gefitinib and erlotinib, changed the treatment system of lung cancer. It was revealed that drug efficacy differs by race (e.g., Caucasians vs. Asians) due to oncogenic driver mutations specific to each race, exemplified by gefitinib / erlotinib. The molecular target drugs for lung cancer with anaplastic lymphoma kinase (ALK) gene translocation (the fusion gene, EML4-ALK) was approved, and those targeting lung cancers addicted ROS1, RET, and HER2 have been under development. Both identification and quantification of gatekeeper mutations need to be performed using lung cancer tissue specimens obtained from patients to improve the treatment for lung cancer patients: (1) identification and quantitation data of targeted mutated proteins, including investigation of mutation heterogeneity within a tissue; (2) exploratory mass spectrometry (MS)-based clinical proteogenomic analysis of mutated proteins; and also importantly (3) analysis of dynamic protein-protein interaction (PPI) networks of proteins significantly related to a subgroup of patients with lung cancer not only with good efficacy but also with acquired resistance. MS-based proteogenomics is a promising approach to directly capture mutated and fusion proteins expressed in a clinical sample. Technological developments are further expected, which will provide a powerful solution for the stratification of patients and drug discovery (Precision Medicine).

First-line treatment of advanced ALK-positive non-small-cell lung cancer

PubMed Central

Gandhi, Shipra; Chen, Hongbin; Zhao, Yujie; Dy, Grace K

2015-01-01

Non-small-cell lung cancer (NSCLC) is one of the leading causes of cancer deaths, both within the US and worldwide. There have been major treatment advances in NSCLC over the past decade with the discovery of molecular drivers of NSCLC, which has ushered in an era of personalized medicine. There are several actionable genetic aberrations in NSCLC, such as epidermal growth factor receptor and anaplastic lymphoma kinase (ALK). In 3%–7% of NSCLC, a chromosomal inversion event in chromosome 2 leads to fusion of a portion of the ALK gene with the echinoderm microtubule–associated protein-like 4 (EML4) gene. The constitutive activation of the ALK fusion oncogene renders it vulnerable to therapeutic intervention. This review focuses on the first-line treatment of advanced ALK-positive NSCLC using ALK inhibitors. Crizotinib was the first agent proven to be efficacious as first-line treatment for ALK-positive NSCLC. However, acquired resistance inevitably develops. The central nervous system is a sanctuary site that represents a common site for disease progression as well. Hence, more potent, selective next-generation ALK inhibitors that are able to cross the blood–brain barrier have been developed for treatment against crizotinib-resistant ALK-positive NSCLC and are also currently being evaluated for first-line therapy as well. In this review, we provide summary of the clinical experience with these drugs in the treatment of ALK-positive NSCLC. PMID:28210152

Assessing the utility of TAM, TPB, and UTAUT for advanced driver assistance systems.

PubMed

Rahman, Md Mahmudur; Lesch, Mary F; Horrey, William J; Strawderman, Lesley

2017-11-01

Advanced Driver Assistance Systems (ADAS) are intended to enhance driver performance and improve transportation safety. The potential benefits of these technologies, such as reduction in number of crashes, enhancing driver comfort or convenience, decreasing environmental impact, etc., have been acknowledged by transportation safety researchers and federal transportation agencies. Although these systems afford safety advantages, they may also challenge the traditional role of drivers in operating vehicles. Driver acceptance, therefore, is essential for the implementation of these systems into the transportation system. Recognizing the need for research into the factors affecting driver acceptance, this study assessed the utility of the Technology Acceptance Model (TAM), the Theory of Planned Behavior (TPB), and the Unified Theory of Acceptance and Use of Technology (UTAUT) for modelling driver acceptance in terms of Behavioral Intention to use an ADAS. Each of these models propose a set of factors that influence acceptance of a technology. Data collection was done using two approaches: a driving simulator approach and an online survey approach. In both approaches, participants interacted with either a fatigue monitoring system or an adaptive cruise control system combined with a lane-keeping system. Based on their experience, participants responded to several survey questions to indicate their attitude toward using the ADAS and their perception of its usefulness, usability, etc. A sample of 430 surveys were collected for this study. Results found that all the models (TAM, TPB, and UTAUT) can explain driver acceptance with their proposed sets of factors, each explaining 71% or more of the variability in Behavioral Intention. Among the models, TAM was found to perform the best in modelling driver acceptance followed by TPB. The findings of this study confirm that these models can be applied to ADAS technologies and that they provide a basis for understanding driver acceptance. Copyright © 2017 Elsevier Ltd. All rights reserved.

Driver fatigue detection based on eye state.

PubMed

Lin, Lizong; Huang, Chao; Ni, Xiaopeng; Wang, Jiawen; Zhang, Hao; Li, Xiao; Qian, Zhiqin

2015-01-01

Nowadays, more and more traffic accidents occur because of driver fatigue. In order to reduce and prevent it, in this study, a calculation method using PERCLOS (percentage of eye closure time) parameter characteristics based on machine vision was developed. It determined whether a driver's eyes were in a fatigue state according to the PERCLOS value. The overall workflow solutions included face detection and tracking, detection and location of the human eye, human eye tracking, eye state recognition, and driver fatigue testing. The key aspects of the detection system incorporated the detection and location of human eyes and driver fatigue testing. The simplified method of measuring the PERCLOS value of the driver was to calculate the ratio of the eyes being open and closed with the total number of frames for a given period. If the eyes were closed more than the set threshold in the total number of frames, the system would alert the driver. Through many experiments, it was shown that besides the simple detection algorithm, the rapid computing speed, and the high detection and recognition accuracies of the system, the system was demonstrated to be in accord with the real-time requirements of a driver fatigue detection system.

Association between older driver characteristics, on-road driving test performance, and crash liability.

PubMed

Keall, Michael D; Frith, William J

2004-06-01

From May 1999, a new system for licensing older drivers was introduced in New Zealand. It included a practical on-road driving test with expanded scope, to be completed every two years from the time the driver turns 80. The relationship between crashes and test performance needed to be studied to inform the debate regarding the testing system. The population studied was all drivers who entered this licensing system during its first three years of operation. They were defined as crash involved if they were involved in an injury crash during the two years following their first licensure under the new system. Logistic regression was used to describe the risk of crash involvement in terms of driving test performance and other driver characteristics. Each driving test failure was associated with a 33% increase in the odds of crash involvement (95% CI 14% to 55%), controlling for age, gender, minor traffic violations, and whether the older driver lived with another licensed driver or not. Minor traffic violations in the two years following the driving test were associated with twice the odds of crash involvement. These results suggest that the new on-road driving test does identify older driver behaviors or limitations that are related to crash liability. It is anticipated that the results presented here will provide essential information for discussing older driver licensing systems, whose impact will grow in importance as the population of drivers ages.

Multi-Sensor Optimal Data Fusion Based on the Adaptive Fading Unscented Kalman Filter

PubMed Central

Gao, Bingbing; Hu, Gaoge; Gao, Shesheng; Gu, Chengfan

2018-01-01

This paper presents a new optimal data fusion methodology based on the adaptive fading unscented Kalman filter for multi-sensor nonlinear stochastic systems. This methodology has a two-level fusion structure: at the bottom level, an adaptive fading unscented Kalman filter based on the Mahalanobis distance is developed and serves as local filters to improve the adaptability and robustness of local state estimations against process-modeling error; at the top level, an unscented transformation-based multi-sensor optimal data fusion for the case of N local filters is established according to the principle of linear minimum variance to calculate globally optimal state estimation by fusion of local estimations. The proposed methodology effectively refrains from the influence of process-modeling error on the fusion solution, leading to improved adaptability and robustness of data fusion for multi-sensor nonlinear stochastic systems. It also achieves globally optimal fusion results based on the principle of linear minimum variance. Simulation and experimental results demonstrate the efficacy of the proposed methodology for INS/GNSS/CNS (inertial navigation system/global navigation satellite system/celestial navigation system) integrated navigation. PMID:29415509

Multi-Sensor Optimal Data Fusion Based on the Adaptive Fading Unscented Kalman Filter.

PubMed

Gao, Bingbing; Hu, Gaoge; Gao, Shesheng; Zhong, Yongmin; Gu, Chengfan

2018-02-06

This paper presents a new optimal data fusion methodology based on the adaptive fading unscented Kalman filter for multi-sensor nonlinear stochastic systems. This methodology has a two-level fusion structure: at the bottom level, an adaptive fading unscented Kalman filter based on the Mahalanobis distance is developed and serves as local filters to improve the adaptability and robustness of local state estimations against process-modeling error; at the top level, an unscented transformation-based multi-sensor optimal data fusion for the case of N local filters is established according to the principle of linear minimum variance to calculate globally optimal state estimation by fusion of local estimations. The proposed methodology effectively refrains from the influence of process-modeling error on the fusion solution, leading to improved adaptability and robustness of data fusion for multi-sensor nonlinear stochastic systems. It also achieves globally optimal fusion results based on the principle of linear minimum variance. Simulation and experimental results demonstrate the efficacy of the proposed methodology for INS/GNSS/CNS (inertial navigation system/global navigation satellite system/celestial navigation system) integrated navigation.

Toyota drivers' experiences with Dynamic Radar Cruise Control, Pre-Collision System, and Lane-Keeping Assist.

PubMed

Eichelberger, Angela H; McCartt, Anne T

2016-02-01

Advanced crash avoidance and driver assistance technologies potentially can prevent or mitigate many crashes. Previous surveys with drivers have found favorable opinions for many advanced technologies; however, these surveys are not necessarily representative of all drivers or all systems. As the technologies spread throughout the vehicle fleet, it is important to continue studying driver acceptance and use of them. This study focused on 2010-2013 Toyota Sienna and Prius models that were equipped with adaptive cruise control, forward collision avoidance, and lane departure warning and prevention (Prius models only). Telephone interviews were conducted in summer 2013 with 183 owners of vehicles with these technologies. About 9 in 10 respondents wanted adaptive cruise control and forward collision avoidance on their next vehicle, and 71% wanted lane departure warning/prevention again. Males and females reported some differences in their experiences with the systems; for example, males were more likely to have turned on lane departure warning/prevention than females, and when using this system, males reported more frequent warnings than did females. Relative to older drivers, drivers age 40 and younger were more likely to have seen or heard a forward collision warning. Consistent with the results in previous surveys of owners of luxury vehicles, the present survey found that driver acceptance of the technologies was high, although less so for lane departure warning/prevention. Experiences with the Toyota systems differed by driver age and gender to a greater degree than in previous surveys, suggesting that the responses of drivers may begin to differ as crash avoidance technology becomes available on a wider variety of vehicles. Crash avoidance technologies potentially can prevent or mitigate many crashes, but their success depends in part on driver acceptance. These systems will be effective only to the extent that drivers use them. Copyright © 2015 Elsevier Ltd and National Safety Council. All rights reserved.

Development of Data Acquisition Card Driver for ICRH System on EAST

NASA Astrophysics Data System (ADS)

Liu, Daming; Luo, Jiarong; Zhao, Yanping; Qin, Chengming

2008-04-01

Presented in this paper is the development of the driver for the data acquisition card with a peripheral component interconnection (PCI) local bus on the ion cyclotron range of frequency heating (ICRH) system. The driver is mainly aimed at the embedded VxWorks system (real-time operating system) which is widely used in various fields of real-time systems. An efficient way is employed to develop this driver, which will advance the real-time control of the ICRH system on the experimental advanced superconductor tokamak (EAST). The driver is designed using the TORNADO integrated development environment (IDE), and implemented in C plus language. The details include the hardware configuration, analogue/digital (A/D) and digital/analogue (D/A) conversion, input and output (I/O) operation of the driver to support over five cards. The data acquisition card can be manipulated in a low-level program and meet the requirements of A/D conversion and D/A outputs.

Fusion and direct reactions around the barrier for the systems {sup 7,9}Be,{sup 7}Li+{sup 238}U

DOE Office of Scientific and Technical Information (OSTI.GOV)

Raabe, R.; Angulo, C.; Charvet, J. L.

2006-10-15

We present new cross section data for the complete fusion of the weakly bound systems {sup 7,9}Be and {sup 7}Li on {sup 238}U at energies around the Coulomb barrier. In the same measurement, yields for direct processes and incomplete fusion are detected. For all systems, a suppression of the complete fusion cross section around and above the barrier is observed. At energies below the barrier, the fusion of the {sup 7}Be+{sup 238}U system shows no enhancement with respect to simple model predictions.

Optical properties and Faraday effect of ceramic terbium gallium garnet for a room temperature Faraday rotator.

PubMed

Yoshida, Hidetsugu; Tsubakimoto, Koji; Fujimoto, Yasushi; Mikami, Katsuhiro; Fujita, Hisanori; Miyanaga, Noriaki; Nozawa, Hoshiteru; Yagi, Hideki; Yanagitani, Takagimi; Nagata, Yutaka; Kinoshita, Hiroo

2011-08-01

The optical properties, Faraday effect and Verdet constant of ceramic terbium gallium garnet (TGG) have been measured at 1064 nm, and were found to be similar to those of single crystal TGG at room temperature. Observed optical characteristics, laser induced bulk-damage threshold and optical scattering properties of ceramic TGG were compared with those of single crystal TGG. Ceramic TGG is a promising Faraday material for high-average-power YAG lasers, Yb fiber lasers and high-peak power glass lasers for inertial fusion energy drivers.

A sensitive HIV-1 envelope induced fusion assay identifies fusion enhancement of thrombin

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cheng, De-Chun; Zhong, Guo-Cai; Su, Ju-Xiang

2010-01-22

To evaluate the interaction between HIV-1 envelope glycoprotein (Env) and target cell receptors, various cell-cell-fusion assays have been developed. In the present study, we established a novel fusion system. In this system, the expression of the sensitive reporter gene, firefly luciferase (FL) gene, in the target cells was used to evaluate cell fusion event. Simultaneously, constitutively expressed Renilla luciferase (RL) gene was used to monitor effector cell number and viability. FL gave a wider dynamic range than other known reporters and the introduction of RL made the assay accurate and reproducible. This system is especially beneficial for investigation of potentialmore » entry-influencing agents, for its power of ruling out the false inhibition or enhancement caused by the artificial cell-number variation. As a case study, we applied this fusion system to observe the effect of a serine protease, thrombin, on HIV Env-mediated cell-cell fusion and have found the fusion enhancement activity of thrombin over two R5-tropic HIV strains.« less

Multi-Sensor Fusion with Interaction Multiple Model and Chi-Square Test Tolerant Filter.

PubMed

Yang, Chun; Mohammadi, Arash; Chen, Qing-Wei

2016-11-02

Motivated by the key importance of multi-sensor information fusion algorithms in the state-of-the-art integrated navigation systems due to recent advancements in sensor technologies, telecommunication, and navigation systems, the paper proposes an improved and innovative fault-tolerant fusion framework. An integrated navigation system is considered consisting of four sensory sub-systems, i.e., Strap-down Inertial Navigation System (SINS), Global Navigation System (GPS), the Bei-Dou2 (BD2) and Celestial Navigation System (CNS) navigation sensors. In such multi-sensor applications, on the one hand, the design of an efficient fusion methodology is extremely constrained specially when no information regarding the system's error characteristics is available. On the other hand, the development of an accurate fault detection and integrity monitoring solution is both challenging and critical. The paper addresses the sensitivity issues of conventional fault detection solutions and the unavailability of a precisely known system model by jointly designing fault detection and information fusion algorithms. In particular, by using ideas from Interacting Multiple Model (IMM) filters, the uncertainty of the system will be adjusted adaptively by model probabilities and using the proposed fuzzy-based fusion framework. The paper also addresses the problem of using corrupted measurements for fault detection purposes by designing a two state propagator chi-square test jointly with the fusion algorithm. Two IMM predictors, running in parallel, are used and alternatively reactivated based on the received information form the fusion filter to increase the reliability and accuracy of the proposed detection solution. With the combination of the IMM and the proposed fusion method, we increase the failure sensitivity of the detection system and, thereby, significantly increase the overall reliability and accuracy of the integrated navigation system. Simulation results indicate that the proposed fault tolerant fusion framework provides superior performance over its traditional counterparts.

Fusion for Space Propulsion and Plasma Liner Driven MTF

NASA Technical Reports Server (NTRS)

Thio, Y.C. Francis; Rodgers, Stephen L. (Technical Monitor)

2001-01-01

The need for fusion propulsion for interplanetary flights is discussed. For a propulsion system, there are three important system attributes: (1) The absolute amount of energy available, (2) the propellant exhaust velocity, and (3) the jet power per unit mass of the propulsion system (specific power). For human exploration and development of the solar system, propellant exhaust velocity in excess of 100 km/s and specific power in excess of 10 kW/kg are required. Chemical combustion cannot meet the requirement in propellant exhaust velocity. Nuclear fission processes typically result in producing energy in the form of heat that needs to be manipulated at temperatures limited by materials to about 2,800 K. Using the energy to heat a low atomic weight propellant cannot overcome the problem. Alternatively the energy can be converted into electricity which is then used to accelerate particles to high exhaust velocity. The necessary power conversion and conditioning equipment, however, increases the mass of the propulsion system for the same jet power by more than two orders of magnitude over chemical system, thus greatly limits the thrust-to-weight ratio attainable. If fusion can be developed, fusion appears to have the best of all worlds in terms of propulsion - it can provide the absolute amount, the propellant exhaust velocity, and the high specific jet power. An intermediate step towards pure fusion propulsion is a bimodal system in which a fission reactor is used to provide some of the energy to drive a fusion propulsion unit. The technical issues related to fusion for space propulsion are discussed. There are similarities as well as differences at the system level between applying fusion to propulsion and to terrestrial electrical power generation. The differences potentially provide a wider window of opportunities for applying fusion to propulsion. For example, pulsed approaches to fusion may be attractive for the propulsion application. This is particularly so in the light of significant development of the enabling pulsed power component technologies that have occurred in the last two decades because of defense and other energy requirements. The extreme states of matter required to produce fusion reactions may be more readily realizable in the pulsed states with less system mass than in steady states. Significant saving in system mass may result in pulsed fusion systems using plasmas in the appropriate density regimes. Magnetized target fusion, which attempts to combine the favorable attributes of magnetic confinement and inertial compression-containment into one single integrated fusion scheme, appears to have benefits that are worth exploring for propulsion application.

Coaxial Plasma Gun Development for the ARPA-E PLX- α Project

NASA Astrophysics Data System (ADS)

Witherspoon, F. Douglas; Case, Andrew; Brockington, Samuel

2015-11-01

We describe the renewed effort to design and build coaxial plasma guns appropriate for a scaling study of spherically imploding plasma liners as a standoff magneto-inertial-fusion driver under the ARPA-E Accelerating Low-Cost Plasma Heating And Assembly (ALPHA) program. HyperV joins LANL, UAH, UNM, BNL, and Tech-X to develop, build, operate and analyze a 60 plasma gun experiment using the existing PLX facility at LANL. The guns will be designed to operate over a scaling range of operating parameters: 0.5-5.0 mg of Ar, Ne, N2, Kr, and Xe; 20-60 km/s; 1016 -1017 cm-3 muzzle density; and up to 7.5 kJ stored energy per gun. Each gun is planned to incorporate contoured gaps, fast dense gas injection and triggering, and innovative integral sparkgap switching and pfn configurations to reduce inductance, cost, and complexity, and to increase efficiency and system reliability. We will describe the overall design approach for the guns and pulsed power systems. This work supported by the ARPA-E ALPHA Program.

Experimental Research in Boost Driver with EDLCs

NASA Astrophysics Data System (ADS)

Matsumoto, Hirokazu

The supply used in servo systems tends to have a high voltage in order to reduce loss and improve the response of motor drives. We propose a new boost motor driver that comprises EDLCs. The proposed driver has a simple structure, wherein the EDLCs are connected in series to the supply, and comprises a charge circuit to charge the EDLCs. The proposed driver has three advantages over conventional boost drivers. The first advantage is that the driver can easily attain the stable boost voltage. The second advantage is that the driver can reduce input power peaks. In a servo system, the input power peaks become greater than the rated power in order to accelerate the motor rapidly. This implies that the equipments that supply power to servo systems must have sufficient power capacity to satisfy the power peaks. The proposed driver can suppress the increase of the power capacity of supply facilities. The third advantage is that the driver can store almost all of the regenerative energy. Conventional drivers have a braking resistor to suppress the increase in the DC link voltage. This causes a considerable reduction in the efficiency. The proposed driver is more efficient than conventional drivers. In this study, the experimental results confirmed the effectiveness of the proposed driver and showed that the drive performance of the proposed driver is the same as that of a conventional driver. Furthermore, it was confirmed that the results of the simulation of a model of the EDLC module, whose capacitance is dependent on the frequency, correspond well with the experimental results.

Design of a Fatigue Detection System for High-Speed Trains Based on Driver Vigilance Using a Wireless Wearable EEG.

PubMed

Zhang, Xiaoliang; Li, Jiali; Liu, Yugang; Zhang, Zutao; Wang, Zhuojun; Luo, Dianyuan; Zhou, Xiang; Zhu, Miankuan; Salman, Waleed; Hu, Guangdi; Wang, Chunbai

2017-03-01

The vigilance of the driver is important for railway safety, despite not being included in the safety management system (SMS) for high-speed train safety. In this paper, a novel fatigue detection system for high-speed train safety based on monitoring train driver vigilance using a wireless wearable electroencephalograph (EEG) is presented. This system is designed to detect whether the driver is drowsiness. The proposed system consists of three main parts: (1) a wireless wearable EEG collection; (2) train driver vigilance detection; and (3) early warning device for train driver. In the first part, an 8-channel wireless wearable brain-computer interface (BCI) device acquires the locomotive driver's brain EEG signal comfortably under high-speed train-driving conditions. The recorded data are transmitted to a personal computer (PC) via Bluetooth. In the second step, a support vector machine (SVM) classification algorithm is implemented to determine the vigilance level using the Fast Fourier transform (FFT) to extract the EEG power spectrum density (PSD). In addition, an early warning device begins to work if fatigue is detected. The simulation and test results demonstrate the feasibility of the proposed fatigue detection system for high-speed train safety.

System for memorizing maximum values

NASA Technical Reports Server (NTRS)

Bozeman, Richard J., Jr. (Inventor)

1992-01-01

The invention discloses a system capable of memorizing maximum sensed values. The system includes conditioning circuitry which receives the analog output signal from a sensor transducer. The conditioning circuitry rectifies and filters the analog signal and provides an input signal to a digital driver, which may be either linear or logarithmic. The driver converts the analog signal to discrete digital values, which in turn triggers an output signal on one of a plurality of driver output lines n. The particular output lines selected is dependent on the converted digital value. A microfuse memory device connects across the driver output lines, with n segments. Each segment is associated with one driver output line, and includes a microfuse that is blown when a signal appears on the associated driver output line.

System for memorizing maximum values

NASA Astrophysics Data System (ADS)

Bozeman, Richard J., Jr.

1992-08-01

The invention discloses a system capable of memorizing maximum sensed values. The system includes conditioning circuitry which receives the analog output signal from a sensor transducer. The conditioning circuitry rectifies and filters the analog signal and provides an input signal to a digital driver, which may be either linear or logarithmic. The driver converts the analog signal to discrete digital values, which in turn triggers an output signal on one of a plurality of driver output lines n. The particular output lines selected is dependent on the converted digital value. A microfuse memory device connects across the driver output lines, with n segments. Each segment is associated with one driver output line, and includes a microfuse that is blown when a signal appears on the associated driver output line.

System for Memorizing Maximum Values

NASA Technical Reports Server (NTRS)

Bozeman, Richard J., Jr. (Inventor)

1996-01-01

The invention discloses a system capable of memorizing maximum sensed values. The system includes conditioning circuitry which receives the analog output signal from a sensor transducer. The conditioning circuitry rectifies and filters the analog signal and provides an input signal to a digital driver, which may be either liner or logarithmic. The driver converts the analog signal to discrete digital values, which in turn triggers an output signal on one of a plurality of driver output lines n. The particular output lines selected is dependent on the converted digital value. A microfuse memory device connects across the driver output lines, with n segments. Each segment is associated with one driver output line, and includes a microfuse that is blown when a signal appears on the associated driver output line.

Shock interaction with a two-gas interface in a novel dual-driver shock tube

NASA Astrophysics Data System (ADS)

Labenski, John R.

Fluid instabilities exist at the interface between two fluids having different densities if the flow velocity and density gradient are anti-parallel or if a shock wave crosses the boundary. The former case is called the Rayleigh-Taylor (R-T) instability and the latter, the Richtmyer-Meshkov (R-M) instability. Small initial perturbations on the interface destabilize and grow into larger amplitude structures leading to turbulent mixing. Instabilities of this type are seen in inertial confinement fusion (ICF) experiments, laser produced plasmas, supernova explosions, and detonations. A novel dual-driver shock tube was used to investigate the growth rate of the R-M instability. One driver is used to create an argon-refrigerant interface, and the other at the opposite end of the driven section generates a shock to force the interface with compressible flows behind the shock. The refrigerant gas in the first driver is seeded with sub-micron oil droplets for visualization of the interface. The interface travels down the driven section past the test section for a fixed amount of time. A stronger shock of Mach 1.1 to 1.3 drives the interface back past the test section where flow diagnostics are positioned. Two schlieren systems record the density fluctuations while light scattering detectors record the density of the refrigerant as a function of position over the interface. A pair of digital cameras take stereo images of the interface, as mapped out by the tracer particles under illumination by a Q-switched ruby laser. The amount of time that the interface is allowed to travel up the driven section determines the interaction time as a control. Comparisons made between the schlieren signals, light scattering detector outputs, and the images quantify the fingered characteristics of the interface and its growth due to shock forcing. The results show that the interface has a distribution of thickness and that the interaction with a shock further broadens the interface. The growth rate was found to exhibit a dependence on the shock strength.

Evaluation of key driver categories influencing sustainable waste management development with the analytic hierarchy process (AHP): Serbia example.

PubMed

Tot, Bojana; Srđević, Bojan; Vujić, Bogdana; Russo, Mário Augusto Tavares; Vujić, Goran

2016-08-01

The problems of waste management have become increasingly complex in recent decades. The increasing amount of generated waste, adopted legislation in the field of waste management, administrative issues, economic impacts and social awareness are important drivers in achieving a sustainable waste management system. However, in practice, there are many other drivers that are often mutually in conflict. The purpose of this research is to define the precise driver and their corresponding sub-drivers, which are relevant for developing a waste management system and, on the basis of their importance, to determine which has the predominant influence on the slow development of a waste management system at the national and regional level, within the Republic of Serbia and similar countries of southeast Europe. This research presents two levels of decision making: the first is a pair-wise comparison of the drivers in relation to the goal and the second is a pair-wise comparison of the sub-drivers in relation to the driver and in relation to the goal. Results of performed analyses on the waste management drivers were integrated via the decision-making process supported by an analytic hierarchy process (AHP). The final results of this research shows that the Institutional-Administrative driver is the most important for developing a sustainable waste management system. © The Author(s) 2016.

Characteristics of fatal road crashes involving unlicensed drivers or riders: Implications for countermeasures.

PubMed

Sagberg, Fridulv

2018-08-01

Drivers or riders without a valid license are involved in 10% of fatal road crashes in Norway. This was shown by an analysis of data from all fatal crashes in the period 2005-2014. A literature review shows that unlicensed drivers have a considerably increased crash risk. Such crashes could be prevented by electronic driver authentication, i.e., a technical system for checking that a driver or rider has legal access to a vehicle before driving is permitted. This can be done by requiring the driver/rider to identify themselves with a national identity number and a unique code or biometric information before driving may commence. The vehicle thereafter verifies license availability and vehicle access by communication with a central register. In more than 80% of fatal crashes with unlicensed drivers/riders, speeding and/or drug influence contributed to the crash. This means that a majority of crashes with unlicensed drivers alternatively could be prevented by already available systems, such as alcolock and speed limit dependent speed adapters. These systems will have a wider influence, by preventing crashes also among licensed drivers. Mandatory implementation of alcolock, speed limiter, and electronic driver authentication in all motorized vehicles is estimated to prevent up to 28% of fatal road crashes, depending on effectiveness of the systems. Copyright © 2018 Elsevier Ltd. All rights reserved.

Multi-Sensor Fusion with Interaction Multiple Model and Chi-Square Test Tolerant Filter

PubMed Central

Yang, Chun; Mohammadi, Arash; Chen, Qing-Wei

2016-01-01

Motivated by the key importance of multi-sensor information fusion algorithms in the state-of-the-art integrated navigation systems due to recent advancements in sensor technologies, telecommunication, and navigation systems, the paper proposes an improved and innovative fault-tolerant fusion framework. An integrated navigation system is considered consisting of four sensory sub-systems, i.e., Strap-down Inertial Navigation System (SINS), Global Navigation System (GPS), the Bei-Dou2 (BD2) and Celestial Navigation System (CNS) navigation sensors. In such multi-sensor applications, on the one hand, the design of an efficient fusion methodology is extremely constrained specially when no information regarding the system’s error characteristics is available. On the other hand, the development of an accurate fault detection and integrity monitoring solution is both challenging and critical. The paper addresses the sensitivity issues of conventional fault detection solutions and the unavailability of a precisely known system model by jointly designing fault detection and information fusion algorithms. In particular, by using ideas from Interacting Multiple Model (IMM) filters, the uncertainty of the system will be adjusted adaptively by model probabilities and using the proposed fuzzy-based fusion framework. The paper also addresses the problem of using corrupted measurements for fault detection purposes by designing a two state propagator chi-square test jointly with the fusion algorithm. Two IMM predictors, running in parallel, are used and alternatively reactivated based on the received information form the fusion filter to increase the reliability and accuracy of the proposed detection solution. With the combination of the IMM and the proposed fusion method, we increase the failure sensitivity of the detection system and, thereby, significantly increase the overall reliability and accuracy of the integrated navigation system. Simulation results indicate that the proposed fault tolerant fusion framework provides superior performance over its traditional counterparts. PMID:27827832

Analysis of decision fusion algorithms in handling uncertainties for integrated health monitoring systems

NASA Astrophysics Data System (ADS)

Zein-Sabatto, Saleh; Mikhail, Maged; Bodruzzaman, Mohammad; DeSimio, Martin; Derriso, Mark; Behbahani, Alireza

2012-06-01

It has been widely accepted that data fusion and information fusion methods can improve the accuracy and robustness of decision-making in structural health monitoring systems. It is arguably true nonetheless, that decision-level is equally beneficial when applied to integrated health monitoring systems. Several decisions at low-levels of abstraction may be produced by different decision-makers; however, decision-level fusion is required at the final stage of the process to provide accurate assessment about the health of the monitored system as a whole. An example of such integrated systems with complex decision-making scenarios is the integrated health monitoring of aircraft. Thorough understanding of the characteristics of the decision-fusion methodologies is a crucial step for successful implementation of such decision-fusion systems. In this paper, we have presented the major information fusion methodologies reported in the literature, i.e., probabilistic, evidential, and artificial intelligent based methods. The theoretical basis and characteristics of these methodologies are explained and their performances are analyzed. Second, candidate methods from the above fusion methodologies, i.e., Bayesian, Dempster-Shafer, and fuzzy logic algorithms are selected and their applications are extended to decisions fusion. Finally, fusion algorithms are developed based on the selected fusion methods and their performance are tested on decisions generated from synthetic data and from experimental data. Also in this paper, a modeling methodology, i.e. cloud model, for generating synthetic decisions is presented and used. Using the cloud model, both types of uncertainties; randomness and fuzziness, involved in real decision-making are modeled. Synthetic decisions are generated with an unbiased process and varying interaction complexities among decisions to provide for fair performance comparison of the selected decision-fusion algorithms. For verification purposes, implementation results of the developed fusion algorithms on structural health monitoring data collected from experimental tests are reported in this paper.

Effectiveness and driver acceptance of a semi-autonomous forward obstacle collision avoidance system.

PubMed

Itoh, Makoto; Horikome, Tatsuya; Inagaki, Toshiyuki

2013-09-01

This paper proposes a semi-autonomous collision avoidance system for the prevention of collisions between vehicles and pedestrians and objects on a road. The system is designed to be compatible with the human-centered automation principle, i.e., the decision to perform a maneuver to avoid a collision is made by the driver. However, the system is partly autonomous in that it turns the steering wheel independently when the driver only applies the brake, indicating his or her intent to avoid the obstacle. With a medium-fidelity driving simulator, we conducted an experiment to investigate the effectiveness of this system for improving safety in emergency situations, as well as its acceptance by drivers. The results indicate that the system effectively improves safety in emergency situations, and the semi-autonomous characteristic of the system was found to be acceptable to drivers. Copyright © 2013 Elsevier Ltd and The Ergonomics Society. All rights reserved.

Drivers Impacting the Adoption of Sustainable Agricultural Management Practices and Production Systems of the Northeast and Southeast U.S

USDA-ARS?s Scientific Manuscript database

Agricultural production responds to economic, social, environmental, and technological drivers operating both internal and external to the production system. These drivers influence producers’ decision making processes, and act to shape the individual production systems through modification of produ...

Speech-based E-mail and driver behavior: effects of an in-vehicle message system interface.

PubMed

Jamson, A Hamish; Westerman, Stephen J; Hockey, G Robert J; Carsten, Oliver M J

2004-01-01

As mobile office technology becomes more advanced, drivers have increased opportunity to process information "on the move." Although speech-based interfaces can minimize direct interference with driving, the cognitive demands associated with such systems may still cause distraction. We studied the effects on driving performance of an in-vehicle simulated "E-mail" message system; E-mails were either system controlled or driver controlled. A high-fidelity, fixed-base driving simulator was used to test 19 participants on a car-following task. Virtual traffic scenarios varying in driving demand. Drivers compensated for the secondary task by adopting longer headways but showed reduced anticipation of braking requirements and shorter time to collision. Drivers were also less reactive when processing E-mails, demonstrated by a reduction in steering wheel inputs. In most circumstances, there were advantages in providing drivers with control over when E-mails were opened. However, during periods without E-mail interaction in demanding traffic scenarios, drivers showed reduced braking anticipation. This may be a result of increased cognitive costs associated with the decision making process when using a driver-controlled interface when the task of scheduling E-mail acceptance is added to those of driving and E-mail response. Actual or potential applications of this research include the design of speech-based in-vehicle messaging systems.

Examination of supplemental driver training and online basic driver education courses : traffic tech.

DOT National Transportation Integrated Search

2012-08-01

The first six months of unsupervised driving are the most : hazardous in a novice drivers driving experience. Most : States adopted graduated driver licensing (GDL) systems : to give novice drivers experience in a protective environment, : gradual...

Studying the response of drivers against different collision warning systems: a review

NASA Astrophysics Data System (ADS)

Muzammel, M.; Yusoff, M. Zuki; Malik, A. Saeed; Mohamad Saad, M. Naufal; Meriaudeau, F.

2017-03-01

The number of vehicle accidents is rapidly increasing and causing significant economic losses in many countries. According to the World Health Organization, road accidents will become the fifth major cause of death by the year 2030. To minimize these accidents different types of collision warning systems have been proposed for motor vehicle drivers. These systems can early detect and warn the drivers about the potential danger, up to a certain accuracy. Many researchers study the effectiveness of these systems by using different methods, including Electroencephalography (EEG). From the literature review, it has been observed that, these systems increase the drivers' response and can help to minimize the accidents that may occur due to drivers unconsciousness. For these collision warning systems, tactile early warnings are found more effective as compared to the auditory and visual early warnings. This review also highlights the areas, where further research can be performed to fully analyze the collision warning system. For example, some contradictions are found among researchers, about these systems' performance for drivers within different age groups. Similarly, most of the EEG studies focus on the front collision warning systems and only give beep sound to alert the drivers. Therefore, EEG study can be performed for the rear end collision warning systems, against proper auditory warning messages which indicate the types of hazards. This EEG study will help to design more friendly collision warning system and may save many lives.

Conceptual design of the beam source for the DEMO Neutral Beam Injectors

NASA Astrophysics Data System (ADS)

Sonato, P.; Agostinetti, P.; Fantz, U.; Franke, T.; Furno, I.; Simonin, A.; Tran, M. Q.

2016-12-01

DEMO (DEMOnstration Fusion Power Plant) is a proposed nuclear fusion power plant that is intended to follow the ITER experimental reactor. The main goal of DEMO will be to demonstrate the possibility to produce electric energy from the fusion reaction. The injection of high energy neutral beams is one of the main tools to heat the plasma up to fusion conditions. A conceptual design of the Neutral Beam Injector (NBI) for the DEMO fusion reactor, is currently being developed by Consorzio RFX in collaboration with other European research institutes. High efficiency and low recirculating power, which are fundamental requirements for the success of DEMO, have been taken into special consideration for the DEMO NBI. Moreover, particular attention has been paid to the issues related to reliability, availability, maintainability and inspectability. A conceptual design of the beam source for the DEMO NBI is here presented featuring 20 sub-sources (two adjacent columns of 10 sub-sources each), following a modular design concept, with each sub-source featuring its radio frequency driver, capable of increasing the reliability and availability of the DEMO NBI. Copper grids with increasing size of the apertures have been adopted in the accelerator, with three main layouts of the apertures (circular apertures, slotted apertures and frame-like apertures for each sub-source). This design, permitting to significantly decrease the stripping losses in the accelerator without spoiling the beam optics, has been investigated with a self-consistent model able to study at the same time the magnetic field, the electrostatic field and the trajectory of the negative ions. Moreover, the status on the R&D carried out in Europe on the ion sources is presented.

Fusion cross sections for reactions involving medium and heavy nucleus-nucleus systems

NASA Astrophysics Data System (ADS)

Atta, Debasis; Basu, D. N.

2014-12-01

Existing data on near-barrier fusion excitation functions of medium and heavy nucleus-nucleus systems have been analyzed by using a simple diffused-barrier formula derived assuming the Gaussian shape of the barrier-height distributions. The fusion cross section is obtained by folding the Gaussian barrier distribution with the classical expression for the fusion cross section for a fixed barrier. The energy dependence of the fusion cross section, thus obtained, provides good description to the existing data on near-barrier fusion and capture excitation functions for medium and heavy nucleus-nucleus systems. The theoretical values for the parameters of the barrier distribution are estimated which can be used for fusion or capture cross-section predictions that are especially important for planning experiments for synthesizing new superheavy elements.

Virtual instrument: remote control and monitoring of an artificial heart driver

NASA Astrophysics Data System (ADS)

Nguyen, An H.; Farrar, David

1993-07-01

A development of a virtual instrument based on the top-down model approach for an artificial heart driver is presented. Driver parameters and status were being dynamically updated on the virtual system at the remote station. The virtual system allowed the remote operator to interact with the physical heart driver as if he/she were at the local station. Besides use as an effective training tool, the system permits an expert operator to monitor and also control the Thoratec heart driver from a distant location. We believe that the virtual instrument for biomedical devices in general and for the Thoratec heart driver in particular, not only improves system reliability but also opens up a real possibility in reducing medical cost. Utilizing the top-down scheme developed recently for telerobotics, realtime operation in both instrument display and remote communication were possible via a low bandwidth telephone medium.

An RFID-Based Intelligent Vehicle Speed Controller Using Active Traffic Signals

PubMed Central

Pérez, Joshué; Seco, Fernando; Milanés, Vicente; Jiménez, Antonio; Díaz, Julio C.; de Pedro, Teresa

2010-01-01

These days, mass-produced vehicles benefit from research on Intelligent Transportation System (ITS). One prime example of ITS is vehicle Cruise Control (CC), which allows it to maintain a pre-defined reference speed, to economize on fuel or energy consumption, to avoid speeding fines, or to focus all of the driver’s attention on the steering of the vehicle. However, achieving efficient Cruise Control is not easy in roads or urban streets where sudden changes of the speed limit can happen, due to the presence of unexpected obstacles or maintenance work, causing, in inattentive drivers, traffic accidents. In this communication we present a new Infrastructure to Vehicles (I2V) communication and control system for intelligent speed control, which is based upon Radio Frequency Identification (RFID) technology for identification of traffic signals on the road, and high accuracy vehicle speed measurement with a Hall effect-based sensor. A fuzzy logic controller, based on sensor fusion of the information provided by the I2V infrastructure, allows the efficient adaptation of the speed of the vehicle to the circumstances of the road. The performance of the system is checked empirically, with promising results. PMID:22219692

Driving performance at lateral system limits during partially automated driving.

PubMed

Naujoks, Frederik; Purucker, Christian; Wiedemann, Katharina; Neukum, Alexandra; Wolter, Stefan; Steiger, Reid

2017-11-01

This study investigated driver performance during system limits of partially automated driving. Using a motion-based driving simulator, drivers encountered different situations in which a partially automated vehicle could no longer safely keep the lateral guidance. Drivers were distracted by a non-driving related task on a touch display or driving without an additional secondary task. While driving in partially automated mode drivers could either take their hands off the steering wheel for only a short period of time (10s, so-called 'Hands-on' variant) or for an extended period of time (120s, so-called 'Hands-off' variant). When the system limit was reached (e.g., when entering a work zone with temporary lines), the lateral vehicle control by the automation was suddenly discontinued and a take-over request was issued to the drivers. Regardless of the hands-off interval and the availability of a secondary task, all drivers managed the transition to manual driving safely. No lane exceedances were observed and the situations were rated as 'harmless' by the drivers. The lack of difference between the hands-off intervals can be partly attributed to the fact that most of the drivers kept contact to the steering wheel, even in the hands-off condition. Although all drivers were able to control the system limits, most of them could not explain why exactly the take-over request was issued. The average helpfulness of the take-over request was rated on an intermediate level. Consequently, providing drivers with information about the reason for a system limit can be recommended. Copyright © 2017 Elsevier Ltd. All rights reserved.

Thermally Activated Driver

NASA Technical Reports Server (NTRS)

Kinard, William H.; Murray, Robert C.; Walsh, Robert F.

1987-01-01

Space-qualified, precise, large-force, thermally activated driver (TAD) developed for use in space on astro-physics experiment to measure abundance of rare actinide-group elements in cosmic rays. Actinide cosmic rays detected using thermally activated driver as heart of event-thermometer (ET) system. Thermal expansion and contraction of silicone oil activates driver. Potential applications in fluid-control systems where precise valve controls are needed.

Flexible Fusion Structure-Based Performance Optimization Learning for Multisensor Target Tracking

PubMed Central

Ge, Quanbo; Wei, Zhongliang; Cheng, Tianfa; Chen, Shaodong; Wang, Xiangfeng

2017-01-01

Compared with the fixed fusion structure, the flexible fusion structure with mixed fusion methods has better adjustment performance for the complex air task network systems, and it can effectively help the system to achieve the goal under the given constraints. Because of the time-varying situation of the task network system induced by moving nodes and non-cooperative target, and limitations such as communication bandwidth and measurement distance, it is necessary to dynamically adjust the system fusion structure including sensors and fusion methods in a given adjustment period. Aiming at this, this paper studies the design of a flexible fusion algorithm by using an optimization learning technology. The purpose is to dynamically determine the sensors’ numbers and the associated sensors to take part in the centralized and distributed fusion processes, respectively, herein termed sensor subsets selection. Firstly, two system performance indexes are introduced. Especially, the survivability index is presented and defined. Secondly, based on the two indexes and considering other conditions such as communication bandwidth and measurement distance, optimization models for both single target tracking and multi-target tracking are established. Correspondingly, solution steps are given for the two optimization models in detail. Simulation examples are demonstrated to validate the proposed algorithms. PMID:28481243

Lane change warning threshold based on driver perception characteristics.

PubMed

Wang, Chang; Sun, Qinyu; Fu, Rui; Li, Zhen; Zhang, Qiong

2018-08-01

Lane Change Warning system (LCW) is exploited to alleviate driver workload and improve the safety performance of lane changes. Depending on the secure threshold, the lane change warning system could transmit caution to drivers. Although the system possesses substantial benefits, it may perturb the conventional operating of the driver and affect driver judgment if the warning threshold does not conform to the driver perception of safety. Therefore, it is essential to establish an appropriate warning threshold to enhance the accuracy rate and acceptability of the lane change warning system. This research aims to identify the threshold that conforms to the driver perception of the ability to safely change lanes with a rear vehicle fast approaching. We propose a theoretical warning model of lane change based on a safe minimum distance and deceleration of the rear vehicle. For the purpose of acquiring the different safety levels of lane changes, 30 licensed drivers are recruited and we obtain the extreme moments represented by driver perception characteristics from a Front Extremity Test and a Rear Extremity Test implemented on the freeway. The required deceleration of the rear vehicle corresponding to the extreme time is calculated according to the proposed model. In light of discrepancies in the deceleration in these extremity experiments, we determine two levels of a hierarchical warning system. The purpose of the primary warning is to remind drivers of the existence of potentially dangerous vehicles and the second warning is used to warn the driver to stop changing lanes immediately. We use the signal detection theory to analyze the data. Ultimately, we confirm that the first deceleration threshold is 1.5 m/s 2 and the second deceleration threshold is 2.7 m/s 2 . The findings provide the basis for the algorithm design of LCW and enhance the acceptability of the intelligent system. Copyright © 2018 Elsevier Ltd. All rights reserved.

FuzzyFusion: an application architecture for multisource information fusion

NASA Astrophysics Data System (ADS)

Fox, Kevin L.; Henning, Ronda R.

2009-04-01

The correlation of information from disparate sources has long been an issue in data fusion research. Traditional data fusion addresses the correlation of information from sources as diverse as single-purpose sensors to all-source multi-media information. Information system vulnerability information is similar in its diversity of sources and content, and in the desire to draw a meaningful conclusion, namely, the security posture of the system under inspection. FuzzyFusionTM, A data fusion model that is being applied to the computer network operations domain is presented. This model has been successfully prototyped in an applied research environment and represents a next generation assurance tool for system and network security.

Driver Behavioral Changes through Interactions with an Automatic Brake System for Collision Avoidance

NASA Astrophysics Data System (ADS)

Itoh, Makoto; Fujiwara, Yusuke; Inagaki, Toshiyuki

This paper discusses driver's behavioral changes as a result of driver's use of an automatic brake system for preventing a rear-end collision from occurring. Three types of automatic brake systems are investigated in this study. Type 1 brake system applies a strong automatic brake when a collision is very imminent. Type 2 brake system initiates brake operation softly when a rear-end crash may be anticipated. Types 1 and 2 are for avoidance of a collision. Type 3 brake system, on the other hand, applies a strong automatic brake to reduce the damage when a collision can not be avoided. An experiment was conducted with a driving simulator in order to analyze the driver's possible behavioral changes. The results showed that the time headway (THW) during car following phase was reduced by use of an automatic brake system of any type. The inverse of time to collision (TTC), which is an index of the driver's brake timing, increased by use of Type 1 brake system when the deceleration rate of the lead vehicle was relatively low. However, the brake timing did not change when the drivers used Type 2 or 3 brake system. As a whole, dangerous behavioral changes, such as overreliance on a brake system, were not observed for either type of brake system.

DriveID: safety innovation through individuation.

PubMed

Sawyer, Ben; Teo, Grace; Mouloua, Mustapha

2012-01-01

The driving task is highly complex and places considerable perceptual, physical and cognitive demands on the driver. As driving is fundamentally an information processing activity, distracted or impaired drivers have diminished safety margins compared with non- distracted drivers (Hancock and Parasuraman, 1992; TRB 1998 a & b). This competition for sensory and decision making capacities can lead to failures that cost lives. Some groups, teens and elderly drivers for example, have patterns of systematically poor perceptual, physical and cognitive performance while driving. Although there are technologies developed to aid these different drivers, these systems are often misused and underutilized. The DriveID project aims to design and develop a passive, automated face identification system capable of robustly identifying the driver of the vehicle, retrieve a stored profile, and intelligently prescribing specific accident prevention systems and driving environment customizations.

Development of the physics driver in NOAA Environmental Modeling System (NEMS)

NASA Astrophysics Data System (ADS)

Lei, H.; Iredell, M.; Tripp, P.

2016-12-01

As a key component of the Next Generation Global Prediction System (NGGPS), a physics driver is developed in the NOAA Environmental Modeling System (NEMS) in order to facilitate the research, development, and transition to operations of innovations in atmospheric physical parameterizations. The physics driver connects the atmospheric dynamic core, the Common Community Physics Package and the other NEMS-based forecast components (land, ocean, sea ice, wave, and space weather). In current global forecasting system, the physics driver has incorporated major existing physics packages including radiation, surface physics, cloud and microphysics, ozone, and stochastic physics. The physics driver is also applicable to external physics packages. The structure adjustment in NEMS by separating the PHYS trunk is to create an open physics package pool. This open platform is beneficial to the enhancement of U.S. weather forecast ability. In addition, with the universal physics driver, the NEMS can also be used for specific functions by connecting external target physics packages through physics driver. The test of its function is to connect a physics dust-radiation model in the system. Then the modified system can be used for dust storm prediction and forecast. The physics driver is also developed into a standalone form. This is to facilitate the development works on physics packages. The developers can save instant fields of meteorology data and snapshots from the running system , and then used them as offline driving data fields to test the new individual physics modules or small modifications to current modules. This prevents the run of whole system for every test.

Risk of thoracic injury from direct steering wheel impact in frontal crashes.

PubMed

Chen, Rong; Gabler, Hampton C

2014-06-01

The combination of airbag and seat belt is considered to be the most effective vehicle safety system. However, despite the widespread availability of airbags and a belt use rate of more than 85%, US drivers involved in crashes continue to be at risk of serious thoracic injury. The objective of this study was to determine the influence of steering wheel deformation on driver injury risk in frontal automobile crash. The analysis is based on cases extracted from the National Automotive Sampling System Crashworthiness Data System database for case years 1993 to 2011. The approach was to compare the adjusted odds of frontal crash injury experienced by drivers in vehicles with and without steering wheel deformation. Among frontal crash cases with belted drivers, observable steering wheel deformation occurred in less than 4% of all cases but accounted for 30% of belted drivers with serious (Abbreviated Injury Scale [AIS] score, 3+) thoracic injuries. Similarly, steering wheel deformation occurred in approximately 13% of unbelted drivers but accounted for 60% of unbelted drivers with serious thoracic injuries. Belted drivers in frontal crashes with steering wheel deformation were found to have two times greater odds of serious thoracic injury. Unbelted drivers were found to have four times greater odds of serious thoracic injury in crashes with steering wheel deformation. In frontal crashes, steering wheel deformation was more likely to occur in unbelted drivers than belted drivers, as well as higher severity crashes and with heavier drivers. The results of the present study show that airbag deployment and seat belt restraint do not completely eliminate the possibility of steering wheel contact. Even with the most advanced restraint systems, there remains an opportunity for further reduction in thoracic injury by continued enhancement to the seat belt and airbag systems. Furthermore, the results showed that steering wheel deformation is an indicator of potential serious thoracic injury and can be useful to prehospital personnel in improving the diagnosis of serious injuries. Prognostic study, level III.

Fusion Materials Research at Oak Ridge National Laboratory in Fiscal Year 2014

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wiffen, Frederick W.; Noe, Susan P.; Snead, Lance Lewis

2014-10-01

The realization of fusion energy is a formidable challenge with significant achievements resulting from close integration of the plasma physics and applied technology disciplines. Presently, the most significant technological challenge for the near-term experiments such as ITER, and next generation fusion power systems, is the inability of current materials and components to withstand the harsh fusion nuclear environment. The overarching goal of the ORNL fusion materials program is to provide the applied materials science support and understanding to underpin the ongoing DOE Office of Science fusion energy program while developing materials for fusion power systems. In doing so the programmore » continues to be integrated both with the larger U.S. and international fusion materials communities, and with the international fusion design and technology communities.« less

23 CFR 1327.3 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-04-01

... RECEIVING INFORMATION FROM THE NATIONAL DRIVER REGISTER PROBLEM DRIVER POINTER SYSTEM § 1327.3 Definitions... drivers who are, based on their records, suspected of being or known to be problem drivers. (d) Driver... personal identifying information in an inquiry compares with the personal identifying information on a...

Studies of longitudinal instability with an electron beam

NASA Astrophysics Data System (ADS)

This progress report covers the research on the 'Study of Longitudinal Instability with an Electron Beam' performed at the University of Maryland during the period from September 1, 1993 to February 28, 1994 of the two-year grant sponsored by the Department of Energy, under Grant No. DEFG02-92ER54178. This research is motivated by the issue of longitudinal instability in induction linacs as drivers for heavy ion inertial fusion. The Fusion Policy Advisory Committee (FPAC) in its final report to DOE (September 1990) identified longitudinal instability as a key physics problem that needs to be solved if an induction linac is to be developed into a successful HIF driver. The FPAC report also stated that 'in parallel' to the design and construction of ILSE 'enhanced theoretical and experimental efforts are required for an improved understanding of potentially serious longitudinal beam instability issues'. The experiment with electron beams in this area is a low-cost way to gain a thorough understanding of the instability and to test computer codes in collaboration with LBL, LLNL, and I. Haber at NRL. The last six months saw the transition of the research activities from phase 1 to phase 2. By the end of last September, the experiments on space-charge waves had been completed. This had fulfilled the first year's goal of this two-year grant. Though the completion of the experiments was one month later than that scheduled and the data analysis still continues up to now, the authors have done much more than was originally proposed.

A Review of Intelligent Driving Style Analysis Systems and Related Artificial Intelligence Algorithms

PubMed Central

Meiring, Gys Albertus Marthinus; Myburgh, Hermanus Carel

2015-01-01

In this paper the various driving style analysis solutions are investigated. An in-depth investigation is performed to identify the relevant machine learning and artificial intelligence algorithms utilised in current driver behaviour and driving style analysis systems. This review therefore serves as a trove of information, and will inform the specialist and the student regarding the current state of the art in driver style analysis systems, the application of these systems and the underlying artificial intelligence algorithms applied to these applications. The aim of the investigation is to evaluate the possibilities for unique driver identification utilizing the approaches identified in other driver behaviour studies. It was found that Fuzzy Logic inference systems, Hidden Markov Models and Support Vector Machines consist of promising capabilities to address unique driver identification algorithms if model complexity can be reduced. PMID:26690164

A Review of Intelligent Driving Style Analysis Systems and Related Artificial Intelligence Algorithms.

PubMed

Meiring, Gys Albertus Marthinus; Myburgh, Hermanus Carel

2015-12-04

In this paper the various driving style analysis solutions are investigated. An in-depth investigation is performed to identify the relevant machine learning and artificial intelligence algorithms utilised in current driver behaviour and driving style analysis systems. This review therefore serves as a trove of information, and will inform the specialist and the student regarding the current state of the art in driver style analysis systems, the application of these systems and the underlying artificial intelligence algorithms applied to these applications. The aim of the investigation is to evaluate the possibilities for unique driver identification utilizing the approaches identified in other driver behaviour studies. It was found that Fuzzy Logic inference systems, Hidden Markov Models and Support Vector Machines consist of promising capabilities to address unique driver identification algorithms if model complexity can be reduced.

Detecting Driver Drowsiness Based on Sensors: A Review

PubMed Central

Sahayadhas, Arun; Sundaraj, Kenneth; Murugappan, Murugappan

2012-01-01

In recent years, driver drowsiness has been one of the major causes of road accidents and can lead to severe physical injuries, deaths and significant economic losses. Statistics indicate the need of a reliable driver drowsiness detection system which could alert the driver before a mishap happens. Researchers have attempted to determine driver drowsiness using the following measures: (1) vehicle-based measures; (2) behavioral measures and (3) physiological measures. A detailed review on these measures will provide insight on the present systems, issues associated with them and the enhancements that need to be done to make a robust system. In this paper, we review these three measures as to the sensors used and discuss the advantages and limitations of each. The various ways through which drowsiness has been experimentally manipulated is also discussed. We conclude that by designing a hybrid drowsiness detection system that combines non-intusive physiological measures with other measures one would accurately determine the drowsiness level of a driver. A number of road accidents might then be avoided if an alert is sent to a driver that is deemed drowsy. PMID:23223151

The driver, the road, the rules … and the rest? A systems-based approach to young driver road safety.

PubMed

Scott-Parker, B; Goode, N; Salmon, P

2015-01-01

The persistent overrepresentation of young drivers in road crashes is universally recognised. A multitude of factors influencing their behaviour and safety have been identified through methods including crash analyses, simulated and naturalistic driving studies, and self-report measures. Across the globe numerous, diverse, countermeasures have been implemented; the design of the vast majority of these has been informed by a driver-centric approach. An alternative approach gaining popularity in transport safety is the systems approach which considers not only the characteristics of the individual, but also the decisions and actions of other actors within the road transport system, along with the interactions amongst them. This paper argues that for substantial improvements to be made in young driver road safety, what has been learnt from driver-centric research needs to be integrated into a systems approach, thus providing a holistic appraisal of the young driver road safety problem. Only then will more effective opportunities and avenues for intervention be realised. Copyright © 2014 Elsevier Ltd. All rights reserved.

Development of driver’s assistant system of additional visual information of blind areas for Gazelle Next

NASA Astrophysics Data System (ADS)

Makarov, V.; Korelin, O.; Koblyakov, D.; Kostin, S.; Komandirov, A.

2018-02-01

The article is devoted to the development of the Advanced Driver Assistance Systems (ADAS) for the GAZelle NEXT car. This project is aimed at developing a visual information system for the driver integrated into the windshield racks. The developed system implements the following functions: assistance in maneuvering and parking; Recognition of road signs; Warning the driver about the possibility of a frontal collision; Control of "blind" zones; "Transparent" vision in the windshield racks, widening the field of view, behind them; Visual and sound information about the traffic situation; Control and descent from the lane of the vehicle; Monitoring of the driver’s condition; navigation system; All-round review. The scheme of action of sensors of the developed system of visual information of the driver is provided. The moments of systems on a prototype of a vehicle are considered. Possible changes in the interior and dashboard of the car are given. The results of the implementation are aimed at the implementation of the system - improved informing of the driver about the environment and the development of an ergonomic interior for this system within the new Functional Salon of the Gazelle Next vehicle equipped with a visual information system for the driver.

Sensor fusion display evaluation using information integration models in enhanced/synthetic vision applications

NASA Technical Reports Server (NTRS)

Foyle, David C.

1993-01-01

Based on existing integration models in the psychological literature, an evaluation framework is developed to assess sensor fusion displays as might be implemented in an enhanced/synthetic vision system. The proposed evaluation framework for evaluating the operator's ability to use such systems is a normative approach: The pilot's performance with the sensor fusion image is compared to models' predictions based on the pilot's performance when viewing the original component sensor images prior to fusion. This allows for the determination as to when a sensor fusion system leads to: poorer performance than one of the original sensor displays, clearly an undesirable system in which the fused sensor system causes some distortion or interference; better performance than with either single sensor system alone, but at a sub-optimal level compared to model predictions; optimal performance compared to model predictions; or, super-optimal performance, which may occur if the operator were able to use some highly diagnostic 'emergent features' in the sensor fusion display, which were unavailable in the original sensor displays.

Jerky driving--An indicator of accident proneness?

PubMed

Bagdadi, Omar; Várhelyi, András

2011-07-01

This study uses continuously logged driving data from 166 private cars to derive the level of jerks caused by the drivers during everyday driving. The number of critical jerks found in the data is analysed and compared with the self-reported accident involvement of the drivers. The results show that the expected number of accidents for a driver increases with the number of critical jerks caused by the driver. Jerk analyses make it possible to identify safety critical driving behaviour or "accident prone" drivers. They also facilitate the development of safety measures such as active safety systems or advanced driver assistance systems, ADAS, which could be adapted for specific groups of drivers or specific risky driving behaviour. Copyright © 2011 Elsevier Ltd. All rights reserved.

Negative ion source development for a photoneutralization based neutral beam system for future fusion reactors

NASA Astrophysics Data System (ADS)

Simonin, A.; Agnello, R.; Bechu, S.; Bernard, J. M.; Blondel, C.; Boeuf, J. P.; Bresteau, D.; Cartry, G.; Chaibi, W.; Drag, C.; Duval, B. P.; de Esch, H. P. L.; Fubiani, G.; Furno, I.; Grand, C.; Guittienne, Ph; Howling, A.; Jacquier, R.; Marini, C.; Morgal, I.

2016-12-01

In parallel to the developments dedicated to the ITER neutral beam (NB) system, CEA-IRFM with laboratories in France and Switzerland are studying the feasibility of a new generation of NB system able to provide heating and current drive for the future DEMOnstration fusion reactor. For the steady-state scenario, the NB system will have to provide a high NB power level with a high wall-plug efficiency (η ˜ 60%). Neutralization of the energetic negative ions by photodetachment (so called photoneutralization), if feasible, appears to be the ideal solution to meet these performances, in the sense that it could offer a high beam neutralization rate (>80%) and a wall-plug efficiency higher than 60%. The main challenge of this new injector concept is the achievement of a very high power photon flux which could be provided by 3 MW Fabry-Perot optical cavities implanted along the 1 MeV D- beam in the neutralizer stage. The beamline topology is tall and narrow to provide laminar ion beam sheets, which will be entirely illuminated by the intra-cavity photon beams propagating along the vertical axis. The paper describes the present R&D (experiments and modelling) addressing the development of a new ion source concept (Cybele source) which is based on a magnetized plasma column. Parametric studies of the source are performed using Langmuir probes in order to characterize and compare the plasma parameters in the source column with different plasma generators, such as filamented cathodes, radio-frequency driver and a helicon antenna specifically developed at SPC-EPFL satisfying the requirements for the Cybele (axial magnetic field of 10 mT, source operating pressure: 0.3 Pa in hydrogen or deuterium). The paper compares the performances of the three plasma generators. It is shown that the helicon plasma generator is a very promising candidate to provide an intense and uniform negative ion beam sheet.

The effect of varying levels of vehicle automation on drivers' lane changing behaviour.

PubMed

Madigan, Ruth; Louw, Tyron; Merat, Natasha

2018-01-01

Much of the Human Factors research into vehicle automation has focused on driver responses to critical scenarios where a crash might occur. However, there is less knowledge about the effects of vehicle automation on drivers' behaviour during non-critical take-over situations, such as driver-initiated lane-changing or overtaking. The current driving simulator study, conducted as part of the EC-funded AdaptIVe project, addresses this issue. It uses a within-subjects design to compare drivers' lane-changing behaviour in conventional manual driving, partially automated driving (PAD) and conditionally automated driving (CAD). In PAD, drivers were required to re-take control from an automated driving system in order to overtake a slow moving vehicle, while in CAD, the driver used the indicator lever to initiate a system-performed overtaking manoeuvre. Results showed that while drivers' acceptance of both the PAD and CAD systems was high, they generally preferred CAD. A comparison of overtaking positions showed that drivers initiated overtaking manoeuvres slightly later in PAD than in manual driving or CAD. In addition, when compared to conventional driving, drivers had higher deviations in lane positioning and speed, along with higher lateral accelerations during lane changes following PAD. These results indicate that even in situations which are not time-critical, drivers' vehicle control after automation is degraded compared to conventional driving.

Cedar Avenue driver assist system evaluation report.

DOT National Transportation Integrated Search

2011-12-01

This paper summarizes an evaluation of the Driver Assist System (DAS) used by the Minnesota Valley Transit Authority (MTVA) for bus shoulder operations. The DAS is a GPS-based technology suite that provides lane-position feedback to the driver via a ...

Semiotic foundation for multisensor-multilook fusion

NASA Astrophysics Data System (ADS)

Myler, Harley R.

1998-07-01

This paper explores the concept of an application of semiotic principles to the design of a multisensor-multilook fusion system. Semiotics is an approach to analysis that attempts to process media in a united way using qualitative methods as opposed to quantitative. The term semiotic refers to signs, or signatory data that encapsulates information. Semiotic analysis involves the extraction of signs from information sources and the subsequent processing of the signs into meaningful interpretations of the information content of the source. The multisensor fusion problem predicated on a semiotic system structure and incorporating semiotic analysis techniques is explored and the design for a multisensor system as an information fusion system is explored. Semiotic analysis opens the possibility of using non-traditional sensor sources and modalities in the fusion process, such as verbal and textual intelligence derived from human observers. Examples of how multisensor/multimodality data might be analyzed semiotically is shown and discussion on how a semiotic system for multisensor fusion could be realized is outlined. The architecture of a semiotic multisensor fusion processor that can accept situational awareness data is described, although an implementation has not as yet been constructed.

The potential for crizotinib in non-small cell lung cancer: a perspective review

PubMed Central

Bang, Yung-Jue

2011-01-01

Tyrosine kinases have a crucial role as key regulators of signaling pathways that influence cell differentiation and growth. Dysregulation of tyrosine kinase-mediated signaling is understood to be an important oncogenic driver. Genetic rearrangements involving the tyrosine kinase anaplastic lymphoma kinase (ALK) gene occur in non-small cell lung cancer (NSCLC), anaplastic large cell lymphomoas, inflammatory myofibroblastic tumors, and other cancers. Cells with abnormal ALK signaling are sensitive to ALK inhibitors such as crizotinib. This review will highlight the discovery of the fusion between echinoderm microtubule-associated protein-like 4 (EML4) and ALK as an oncogenic driver, recognition of other ALK gene rearrangements in NSCLC, and the confirmation that crizotinib is an effective treatment for patients with ALK-positive NSCLC. Work is underway to further define the role for crizotinib in the treatment of ALK-positive lung cancer and other cancers and to investigate the molecular mechanisms for resistance to ALK inhibition with crizotinib. PMID:22084642

A novel active heads-up display for driver assistance.

PubMed

Doshi, Anup; Cheng, Shinko Yuanhsien; Trivedi, Mohan Manubhai

2009-02-01

In this paper, we introduce a novel laser-based wide-area heads-up windshield display which is capable of actively interfacing with a human as part of a driver assistance system. The dynamic active display (DAD) is a unique prototype interface that presents safety-critical visual icons to the driver in a manner that minimizes the deviation of his or her gaze direction without adding to unnecessary visual clutter. As part of an automotive safety system, the DAD presents alerts in the field of view of the driver only if necessary, which is based upon the state and pose of the driver, vehicle, and environment. This paper examines the effectiveness of DAD through a comprehensive comparative experimental evaluation of a speed compliance driver assistance system, which is implemented on a vehicular test bed. Three different types of display protocols for assisting a driver to comply with speed limits are tested on actual roadways, and these are compared with a conventional dashboard display. Given the inclination, drivers who are given an overspeed warning alert reduced the time required to slow down to the speed limit by 38% (p < 0.01) as compared with the drivers not given the alert. Additionally, certain alerts decreased distraction levels by reducing the time spent looking away from the road by 63% (p < 0.01). Ultimately, these alerts demonstrate the utility and promise of the DAD system.

3D Neutronic Analysis in MHD Calculations at ARIES-ST Fusion Reactors Systems

NASA Astrophysics Data System (ADS)

Hançerliogulları, Aybaba; Cini, Mesut

2013-10-01

In this study, we developed new models for liquid wall (FW) state at ARIES-ST fusion reactor systems. ARIES-ST is a 1,000 MWe fusion reactor system based on a low aspect ratio ST plasma. In this article, we analyzed the characteristic properties of magnetohydrodynamics (MHD) and heat transfer conditions by using Monte-Carlo simulation methods (ARIES Team et al. in Fusion Eng Des 49-50:689-695, 2000; Tillack et al. in Fusion Eng Des 65:215-261, 2003) . In fusion applications, liquid metals are traditionally considered to be the best working fluids. The working liquid must be a lithium-containing medium in order to provide adequate tritium that the plasma is self-sustained and that the fusion is a renewable energy source. As for Flibe free surface flows, the MHD effects caused by interaction with the mean flow is negligible, while a fairly uniform flow of thick can be maintained throughout the reactor based on 3-D MHD calculations. In this study, neutronic parameters, that is to say, energy multiplication factor radiation, heat flux and fissile fuel breeding were researched for fusion reactor with various thorium and uranium molten salts. Sufficient tritium amount is needed for the reactor to work itself. In the tritium breeding ratio (TBR) >1.05 ARIES-ST fusion model TBR is >1.1 so that tritium self-sufficiency is maintained for DT fusion systems (Starke et al. in Fusion Energ Des 84:1794-1798, 2009; Najmabadi et al. in Fusion Energ Des 80:3-23, 2006).

Smart Roadside System for Driver Assistance and Safety Warnings: Framework and Applications

PubMed Central

Jang, Jeong Ah; Kim, Hyun Suk; Cho, Han Byeog

2011-01-01

The use of newly emerging sensor technologies in traditional roadway systems can provide real-time traffic services to drivers through Telematics and Intelligent Transport Systems (ITSs). This paper introduces a smart roadside system that utilizes various sensors for driver assistance and traffic safety warnings. This paper shows two road application models for a smart roadside system and sensors: a red-light violation warning system for signalized intersections, and a speed advisory system for highways. Evaluation results for the two services are then shown using a micro-simulation method. In the given real-time applications for drivers, the framework and certain algorithms produce a very efficient solution with respect to the roadway type features and sensor type use. PMID:22164025

Assessment of a drowsy driver warning system for heavy-vehicle drivers : final report

DOT National Transportation Integrated Search

2009-04-01

Drowsiness has a globally negative impact on performance, slowing reaction time, decreasing situational awareness, and impairing judgment. A field operational test of an early prototype Drowsy Driver Warning System was conducted as a result of 12 yea...

Plasma-Jet-Driven Magneto-Inertial Fusion (PJMIF): Physics and Design for a Plasma Liner Formation Experiment

NASA Astrophysics Data System (ADS)

Hsu, Scott; Cassibry, Jason; Witherspoon, F. Douglas

2014-10-01

Spherically imploding plasma liners are a potential standoff compression driver for magneto-inertial fusion, which is a hybrid of and operates in an intermediate density between those of magnetic and inertial fusion. We propose to use an array of merging supersonic plasma jets to form a spherically imploding plasma liner. The jets are to be formed by pulsed coaxial guns with contoured electrodes that are placed sufficiently far from the location of target compression such that no hardware is repetitively destroyed. As such, the repetition rate can be higher (e.g., 1 Hz) and ultimately the power-plant economics can be more attractive than most other MIF approaches. During the R&D phase, a high experimental shot rate at reasonably low cost (e.g., < 1 k/shot) may be achieved with excellent diagnostic access, thus enabling a rapid learning rate. After some background on PJMIF and its prospects for reactor-relevant energy gain, this poster describes the physics objectives and design of a proposed 60-gun plasma-liner-formation experiment, which will provide experimental data on: (i) scaling of peak liner ram pressure versus initial jet parameters, (ii) liner non-uniformity characterization and control, and (iii) control of liner profiles for eventual gain optimization.

MagLIF scaling on Z and future machines

NASA Astrophysics Data System (ADS)

Slutz, Stephen; Stygar, William; Gomez, Matthew; Campbell, Edward; Peterson, Kyle; Sefkow, Adam; Sinars, Daniel; Vesey, Roger

2015-11-01

The MagLIF (Magnetized Liner Inertial Fusion) concept [S.A. Slutz et al Phys. Plasmas 17, 056303, 2010] has demonstrated [M.R. Gomez et al., PRL 113, 155003, 2014] fusion-relevant plasma conditions on the Z machine. We present 2D numerical simulations of the scaling of MagLIF on Z indicating that deuterium/tritium (DT) fusion yields greater than 100 kJ could be possible on Z when operated at a peak current of 25 MA. Much higher yields are predicted for MagLIF driven with larger peak currents. Two high performance pulsed-power machines (Z300 and Z800) have been designed based on Linear Transformer Driver (LTD) technology. The Z300 design would provide approximately 48 MA to a MagLIF load, while Z800 would provide about 66 MA. We used a parameterized Thevenin equivalent circuit to drive a series of 1D and 2D numerical simulations with currents between and beyond these two designs. Our simulations indicate that 5-10 MJ yields may be possible with Z300, while yields of about 1 GJ may be possible with Z800. Sandia is a multiprogram laboratory operated by Sandia Corporation, a Lockheed Martin Company, for the United States Department of Energy's National Nuclear Security Administration under contract DE-AC04-94AL85000.

Inertial Fusion Target Physics Advantages with the Krypton Fluoride Laser

NASA Astrophysics Data System (ADS)

Obenschain, Stephen

2010-11-01

The krypton fluoride (KrF) laser's short wavelength, broad bandwidth and capability to provide extremely uniform target illumination are advantages towards obtaining high gain direct drive implosions. The short wavelength helps suppress deleterious laser-plasma instabilities, and allows one to employ higher ablation pressures. In addition, the KrF architecture allows one to zoom down the focal diameter to follow the size of the imploding pellet, thereby improving the coupling efficiency. The NRL researchers have been conducting theoretical and experimental studies to quantify the beneficial effects of utilizing KrF light. Experiments using the Nike facility have confirmed that KrF light significantly increases the threshold for laser-plasma instability. This presentation will discuss the observed target physics with KrF light and its effects towards facilitating the high gains needed for power production with inertial fusion. Simulations indicate that shock ignited designs can achieve gains above 200 with KrF energies as low a 1 megajoule. For fusion energy a laser driver must be capable of high repetition rates (5-10 Hz) along with adequate efficiency and durability. The Electra KrF 30-cm aperture electron-beam-pumped amplifier has demonstrated long duration continuous operation at high-repetition rates. This and other advances show that the KrF laser should be able to meet the requirements.

Critical need for MFE: the Alcator DX advanced divertor test facility

NASA Astrophysics Data System (ADS)

Vieira, R.; Labombard, B.; Marmar, E.; Irby, J.; Wolf, S.; Bonoli, P.; Fiore, C.; Granetz, R.; Greenwald, M.; Hutchinson, I.; Hubbard, A.; Hughes, J.; Lin, Y.; Lipschultz, B.; Parker, R.; Porkolab, M.; Reinke, M.; Rice, J.; Shiraiwa, S.; Terry, J.; Theiler, C.; Wallace, G.; White, A.; Whyte, D.; Wukitch, S.

2013-10-01

Three critical challenges must be met before a steady-state, power-producing fusion reactor can be realized: how to (1) safely handle extreme plasma exhaust power, (2) completely suppress material erosion at divertor targets and (3) do this while maintaining a burning plasma core. Advanced divertors such as ``Super X'' and ``X-point target'' may allow a fully detached, low temperature plasma to be produced in the divertor while maintaining a hot boundary layer around a clean plasma core - a potential game-changer for magnetic fusion. No facility currently exists to test these ideas at the required parallel heat flux densities. Alcator DX will be a national facility, employing the high magnetic field technology of Alcator combined with high-power ICRH and LHCD to test advanced divertor concepts at FNSF/DEMO power exhaust densities and plasma pressures. Its extended vacuum vessel contains divertor cassettes with poloidal field coils for conventional, snowflake, super-X and X-point target geometries. Divertor and core plasma performance will be explored in regimes inaccessible in conventional devices. Reactor relevant ICRF and LH drivers will be developed, utilizing high-field side launch platforms for low PMI. Alcator DX will inform the conceptual development and accelerate the readiness-for-deployment of next-step fusion facilities.

Driver face recognition as a security and safety feature

NASA Astrophysics Data System (ADS)

Vetter, Volker; Giefing, Gerd-Juergen; Mai, Rudolf; Weisser, Hubert

1995-09-01

We present a driver face recognition system for comfortable access control and individual settings of automobiles. The primary goals are the prevention of car thefts and heavy accidents caused by unauthorized use (joy-riders), as well as the increase of safety through optimal settings, e.g. of the mirrors and the seat position. The person sitting on the driver's seat is observed automatically by a small video camera in the dashboard. All he has to do is to behave cooperatively, i.e. to look into the camera. A classification system validates his access. Only after a positive identification, the car can be used and the driver-specific environment (e.g. seat position, mirrors, etc.) may be set up to ensure the driver's comfort and safety. The driver identification system has been integrated in a Volkswagen research car. Recognition results are presented.

Recurrent DUX4 fusions in B cell acute lymphoblastic leukemia of adolescents and young adults.

PubMed

Yasuda, Takahiko; Tsuzuki, Shinobu; Kawazu, Masahito; Hayakawa, Fumihiko; Kojima, Shinya; Ueno, Toshihide; Imoto, Naoto; Kohsaka, Shinji; Kunita, Akiko; Doi, Koichiro; Sakura, Toru; Yujiri, Toshiaki; Kondo, Eisei; Fujimaki, Katsumichi; Ueda, Yasunori; Aoyama, Yasutaka; Ohtake, Shigeki; Takita, Junko; Sai, Eirin; Taniwaki, Masafumi; Kurokawa, Mineo; Morishita, Shinichi; Fukayama, Masashi; Kiyoi, Hitoshi; Miyazaki, Yasushi; Naoe, Tomoki; Mano, Hiroyuki

2016-05-01

The oncogenic mechanisms underlying acute lymphoblastic leukemia (ALL) in adolescents and young adults (AYA; 15-39 years old) remain largely elusive. Here we have searched for new oncogenes in AYA-ALL by performing RNA-seq analysis of Philadelphia chromosome (Ph)-negative AYA-ALL specimens (n = 73) with the use of a next-generation sequencer. Interestingly, insertion of D4Z4 repeats containing the DUX4 gene into the IGH locus was frequently identified in B cell AYA-ALL, leading to a high level of expression of DUX4 protein with an aberrant C terminus. A transplantation assay in mice demonstrated that expression of DUX4-IGH in pro-B cells was capable of generating B cell leukemia in vivo. DUX4 fusions were preferentially detected in the AYA generation. Our data thus show that DUX4 can become an oncogenic driver as a result of somatic chromosomal rearrangements and that AYA-ALL may be a clinical entity distinct from ALL at other ages.

A De Novo Mouse Model of C11orf95-RELA Fusion-Driven Ependymoma Identifies Driver Functions in Addition to NF-κB.

PubMed

Ozawa, Tatsuya; Arora, Sonali; Szulzewsky, Frank; Juric-Sekhar, Gordana; Miyajima, Yoshiteru; Bolouri, Hamid; Yasui, Yoshie; Barber, Jason; Kupp, Robert; Dalton, James; Jones, Terreia S; Nakada, Mitsutoshi; Kumabe, Toshihiro; Ellison, David W; Gilbertson, Richard J; Holland, Eric C

2018-06-26

The majority of supratentorial ependymomas (ST-ependymomas) have few mutations but frequently display chromothripsis of chromosome 11q that generates a fusion between C11orf95 and RELA (RELA FUS ). Neural stem cells transduced with RELA FUS ex vivo form ependymomas when implanted in the brain. These tumors display enhanced NF-κB signaling, suggesting that this aberrant signal is the principal mechanism of oncogenesis. However, it is not known whether RELA FUS is sufficient to drive de novo ependymoma tumorigenesis in the brain and, if so, whether these tumors also arise from neural stem cells. We show that RELA FUS drives ST-ependymoma formation from periventricular neural stem cells in mice and that RELA FUS -induced tumorigenesis is likely dependent on a series of cell signaling pathways in addition to NF-κB. Copyright © 2018 The Author(s). Published by Elsevier Inc. All rights reserved.

The subclonal complexity of STIL-TAL1+ T-cell acute lymphoblastic leukaemia.

PubMed

Furness, Caroline L; Mansur, Marcela B; Weston, Victoria J; Ermini, Luca; van Delft, Frederik W; Jenkinson, Sarah; Gale, Rosemary; Harrison, Christine J; Pombo-de-Oliveira, Maria S; Sanchez-Martin, Marta; Ferrando, Adolfo A; Kearns, Pamela; Titley, Ian; Ford, Anthony M; Potter, Nicola E; Greaves, Mel

2018-03-20

Single-cell genetics were used to interrogate clonal complexity and the sequence of mutational events in STIL-TAL1+ T-ALL. Single-cell multicolour FISH was used to demonstrate that the earliest detectable leukaemia subclone contained the STIL-TAL1 fusion and copy number loss of 9p21.3 (CDKN2A/CDKN2B locus), with other copy number alterations including loss of PTEN occurring as secondary subclonal events. In three cases, multiplex qPCR and phylogenetic analysis were used to produce branching evolutionary trees recapitulating the snapshot history of T-ALL evolution in this leukaemia subtype, which confirmed that mutations in key T-ALL drivers, including NOTCH1 and PTEN, were subclonal and reiterative in distinct subclones. Xenografting confirmed that self-renewing or propagating cells were genetically diverse. These data suggest that the STIL-TAL1 fusion is a likely founder or truncal event. Therapies targeting the TAL1 auto-regulatory complex are worthy of further investigation in T-ALL.

Applying design principles to fusion reactor configurations for propulsion in space

NASA Technical Reports Server (NTRS)

Carpenter, Scott A.; Deveny, Marc E.; Schulze, Norman R.

1993-01-01

The application of fusion power to space propulsion requires rethinking the engineering-design solution to controlled-fusion energy. Whereas the unit cost of electricity (COE) drives the engineering-design solution for utility-based fusion reactor configurations; initial mass to low earth orbit (IMLEO), specific jet power (kW(thrust)/kg(engine)), and reusability drive the engineering-design solution for successful application of fusion power to space propulsion. We applied three design principles (DP's) to adapt and optimize three candidate-terrestrial-fusion-reactor configurations for propulsion in space. The three design principles are: provide maximum direct access to space for waste radiation, operate components as passive radiators to minimize cooling-system mass, and optimize the plasma fuel, fuel mix, and temperature for best specific jet power. The three candidate terrestrial fusion reactor configurations are: the thermal barrier tandem mirror (TBTM), field reversed mirror (FRM), and levitated dipole field (LDF). The resulting three candidate space fusion propulsion systems have their IMLEO minimized and their specific jet power and reusability maximized. We performed a preliminary rating of these configurations and concluded that the leading engineering-design solution to space fusion propulsion is a modified TBTM that we call the Mirror Fusion Propulsion System (MFPS).

Gradient-based multiresolution image fusion.

PubMed

Petrović, Valdimir S; Xydeas, Costas S

2004-02-01

A novel approach to multiresolution signal-level image fusion is presented for accurately transferring visual information from any number of input image signals, into a single fused image without loss of information or the introduction of distortion. The proposed system uses a "fuse-then-decompose" technique realized through a novel, fusion/decomposition system architecture. In particular, information fusion is performed on a multiresolution gradient map representation domain of image signal information. At each resolution, input images are represented as gradient maps and combined to produce new, fused gradient maps. Fused gradient map signals are processed, using gradient filters derived from high-pass quadrature mirror filters to yield a fused multiresolution pyramid representation. The fused output image is obtained by applying, on the fused pyramid, a reconstruction process that is analogous to that of conventional discrete wavelet transform. This new gradient fusion significantly reduces the amount of distortion artefacts and the loss of contrast information usually observed in fused images obtained from conventional multiresolution fusion schemes. This is because fusion in the gradient map domain significantly improves the reliability of the feature selection and information fusion processes. Fusion performance is evaluated through informal visual inspection and subjective psychometric preference tests, as well as objective fusion performance measurements. Results clearly demonstrate the superiority of this new approach when compared to conventional fusion systems.

Barrier distributions and signatures of transfer channels in the Ca40+Ni58,64 fusion reactions at energies around and below the Coulomb barrier

NASA Astrophysics Data System (ADS)

Bourgin, D.; Courtin, S.; Haas, F.; Stefanini, A. M.; Montagnoli, G.; Goasduff, A.; Montanari, D.; Corradi, L.; Fioretto, E.; Huiming, J.; Scarlassara, F.; Rowley, N.; Szilner, S.; Mijatović, T.

2014-10-01

Background: The nuclear structure of colliding nuclei is known to influence the fusion process. Couplings of the relative motion to nuclear shape deformations and vibrations lead to an enhancement of the sub-barrier fusion cross section in comparison with the predictions of one-dimensional barrier penetration models. This enhancement is explained by coupled-channels calculations including these couplings. The sub-barrier fusion cross section is also affected by nucleon transfer channels between the colliding nuclei. Purpose: The aim of the present experiment is to investigate the influence of the projectile and target nuclear structures on the fusion cross sections in the Ca40+Ni58 and Ca40+Ni64 systems. Methods: The experimental and theoretical fusion excitation functions as well as the barrier distributions were compared for these two systems. Coupled-channels calculations were performed using the ccfull code. Results: Good agreement was found between the measured and calculated fusion cross sections for the Ca40+Ni58 system. The situation is different for the Ca40+Ni64 system where the coupled-channels calculations with no nucleon transfer clearly underestimate the fusion cross sections below the Coulomb barrier. The fusion excitation function was, however, well reproduced at low and high energies by including the coupling to the neutron pair-transfer channel in the calculations. Conclusions: The nuclear structure of the colliding nuclei influences the fusion cross sections below the Coulomb barrier for both Ca40+Ni58,64 systems. Moreover, we highlighted the effect of the neutron pair-transfer channel on the fusion cross sections in Ca40+Ni64.

Device Driver Safety Through a Reference Validation Mechanism

DTIC Science & Technology

2008-05-01

microkernels and other research operat- ing systems [2, 9, 21, 24] run device drivers in user space ∗Supported by NICECAP cooperative agreement FA8750...device driver architecture in the Nexus trusted operating system [28], which has many similarities to traditional microkernels , including hardware... microkernel operating sys- tems, every flaw in a device driver is a potential secu- rity hole given the absence of mechanisms to contain the (mis

The use of technology to address patterns of risk among teenage drivers.

PubMed

Brovold, Shawn; Ward, Nic; Donath, Max; Simon, Stephen; Shankwitz, Craig; Creaser, Janet

2007-01-01

The crash risk of teens is high, with fatal crash rates of teen drivers higher than any other age group. New approaches to reduce teen traffic fatalities are clearly needed. A possible approach to reduce the incidence of teen driver crashes and fatalities is through the use of vehicle-based intelligent driver support systems. To be most effective, the system should address the behaviors associated with an overwhelming number of teen fatal crashes: speed, low seatbelt use, and alcohol impairment. In-vehicle technology also offers an opportunity to address the issue of inexperience through enforcement of certain Graduated Driver's License provisions. To fully understand the capability of such technologies, there should be a concerted effort to further their development, and human factors testing should take place to understand their effects on the driver. If successfully implemented, a Teen Driver Support System (TDSS), such as the one described here, could significantly decrease the number of teens killed in traffic crashes.

Drivers' communicative interactions: on-road observations and modelling for integration in future automation systems.

PubMed

Portouli, Evangelia; Nathanael, Dimitris; Marmaras, Nicolas

2014-01-01

Social interactions with other road users are an essential component of the driving activity and may prove critical in view of future automation systems; still up to now they have received only limited attention in the scientific literature. In this paper, it is argued that drivers base their anticipations about the traffic scene to a large extent on observations of social behaviour of other 'animate human-vehicles'. It is further argued that in cases of uncertainty, drivers seek to establish a mutual situational awareness through deliberate communicative interactions. A linguistic model is proposed for modelling these communicative interactions. Empirical evidence from on-road observations and analysis of concurrent running commentary by 25 experienced drivers support the proposed model. It is suggested that the integration of a social interactions layer based on illocutionary acts in future driving support and automation systems will improve their performance towards matching human driver's expectations. Practitioner Summary: Interactions between drivers on the road may play a significant role in traffic coordination. On-road observations and running commentaries are presented as empirical evidence to support a model of such interactions; incorporation of drivers' interactions in future driving support and automation systems may improve their performance towards matching driver's expectations.

Establishment of a tamoxifen-inducible Cre-driver mouse strain for widespread and temporal genetic modification in adult mice.

PubMed

Ichise, Hirotake; Hori, Akiko; Shiozawa, Seiji; Kondo, Saki; Kanegae, Yumi; Saito, Izumu; Ichise, Taeko; Yoshida, Nobuaki

2016-07-29

Temporal genetic modification of mice using the ligand-inducible Cre/loxP system is an important technique that allows the bypass of embryonic lethal phenotypes and access to adult phenotypes. In this study, we generated a tamoxifen-inducible Cre-driver mouse strain for the purpose of widespread and temporal Cre recombination. The new line, named CM32, expresses the GFPneo-fusion gene in a wide variety of tissues before FLP recombination and tamoxifen-inducible Cre after FLP recombination. Using FLP-recombined CM32 mice (CM32Δ mice) and Cre reporter mouse lines, we evaluated the efficiency of Cre recombination with and without tamoxifen administration to adult mice, and found tamoxifen-dependent induction of Cre recombination in a variety of adult tissues. In addition, we demonstrated that conditional activation of an oncogene could be achieved in adults using CM32Δ mice. CM32Δ;T26 mice, which harbored a Cre recombination-driven, SV40 large T antigen-expressing transgene, were viable and fertile. No overt phenotype was found in the mice up to 3 months after birth. Although they displayed pineoblastomas (pinealoblastomas) and/or thymic enlargement due to background Cre recombination by 6 months after birth, they developed epidermal hyperplasia when administered tamoxifen. Collectively, our results suggest that the CM32Δ transgenic mouse line can be applied to the assessment of adult phenotypes in mice with loxP-flanked transgenes.

Revisions to the JDL data fusion model

NASA Astrophysics Data System (ADS)

Steinberg, Alan N.; Bowman, Christopher L.; White, Franklin E.

1999-03-01

The Data Fusion Model maintained by the Joint Directors of Laboratories (JDL) Data Fusion Group is the most widely-used method for categorizing data fusion-related functions. This paper discusses the current effort to revise the expand this model to facilitate the cost-effective development, acquisition, integration and operation of multi- sensor/multi-source systems. Data fusion involves combining information - in the broadest sense - to estimate or predict the state of some aspect of the universe. These may be represented in terms of attributive and relational states. If the job is to estimate the state of a people, it can be useful to include consideration of informational and perceptual states in addition to the physical state. Developing cost-effective multi-source information systems requires a method for specifying data fusion processing and control functions, interfaces, and associate databases. The lack of common engineering standards for data fusion systems has been a major impediment to integration and re-use of available technology: current developments do not lend themselves to objective evaluation, comparison or re-use. This paper reports on proposed revisions and expansions of the JDL Data FUsion model to remedy some of these deficiencies. This involves broadening the functional model and related taxonomy beyond the original military focus, and integrating the Data Fusion Tree Architecture model for system description, design and development.

Design Considerations for Clean QED Fusion Propulsion Systems

NASA Astrophysics Data System (ADS)

Bussard, Robert W.; Jameson, Lorin W.

1994-07-01

The direct production of electric power appears possible from fusion reactions between fuels whose products consist solely of charged particles and thus do not present radiation hazards from energetic neutron production, as do reactions involving deuteron-bearing fuels. Among these are the fuels p, 11B, 3He, and 6Li. All of these can be ``burned'' in inertial-electrostatic-fusion (IEF) devices to power QED fusion-electric rocket engines. These IEF sources provide direct-converted electrical power at high voltage (MeV) to drive e-beams for efficient propellant heating to extreme temperatures, with resulting high specific impulse performance capabilities. IEF/QED engine systems using p11B can outperform all other advanced concepts for controlled fusion propulsion by 2-3 orders of magnitude, while 6Li6Li fusion yields one order of magnitude less advance. Either of these fusion rocket propulsion systems can provide very rapid transit for solar system missions, with high payload fractions in single-stage vehicles. The 3He3He reaction can not be used practically for direct electric conversion because of the wide spread in energy of its fusion products. However, it may eventually prove useful for thermal/electrical power generation in central station power plants, or for direct-fusion-product (DFP) propellant heatingin advanced deep-space rocket engines.

Keep the driver in control: Automating automobiles of the future.

PubMed

Banks, Victoria A; Stanton, Neville A

2016-03-01

Automated automobiles will be on our roads within the next decade but the role of the driver has not yet been formerly recognised or designed. Rather, the driver is often left in a passive monitoring role until they are required to reclaim control from the vehicle. This research aimed to test the idea of driver-initiated automation, in which the automation offers decision support that can be either accepted or ignored. The test case examined a combination of lateral and longitudinal control in addition to an auto-overtake system. Despite putting the driver in control of the automated systems by enabling them to accept or ignore behavioural suggestions (e.g. overtake), there were still issues associated with increased workload and decreased trust. These issues are likely to have arisen due to the way in which the automated system has been designed. Recommendations for improvements in systems design have been made which are likely to improve trust and make the role of the driver more transparent concerning their authority over the automated system. Copyright © 2015 Elsevier Ltd and The Ergonomics Society. All rights reserved.

Fusion hindrance at deep sub-barrier energies for the 11B+197Au system

NASA Astrophysics Data System (ADS)

Shrivastava, A.; Mahata, K.; Nanal, V.; Pandit, S. K.; Parkar, V. V.; Rout, P. C.; Dokania, N.; Ramachandran, K.; Kumar, A.; Chatterjee, A.; Kailas, S.

2017-09-01

Fusion cross sections for the 11B+197Au system have been measured at energies around and deep below the Coulomb barrier, to probe the occurrence of fusion hindrance in case of asymmetric systems. A deviation with respect to the standard coupled channels calculations has been observed at the lowest energy. The results have been compared with an adiabatic model calculation that considers a damping of the coupling strength for a gradual transition from sudden to adiabatic regime at very low energies. The data could be explained without inclusion of the damping factor. This implies that the influence of fusion hindrance is not significant within the measured energy range for this system. The present result is consistent with the observed trend between the degree of fusion hindrance and the charge product that reveals a weaker influence of hindrance on fusion involving lighter projectiles on heavy targets.

Feasibility of a GNSS-Probe for Creating Digital Maps of High Accuracy and Integrity

NASA Astrophysics Data System (ADS)

Vartziotis, Dimitris; Poulis, Alkis; Minogiannis, Alexandros; Siozos, Panayiotis; Goudas, Iraklis; Samson, Jaron; Tossaint, Michel

The “ROADSCANNER” project addresses the need for increased accuracy and integrity Digital Maps (DM) utilizing the latest developments in GNSS, in order to provide the required datasets for novel applications, such as navigation based Safety Applications, Advanced Driver Assistance Systems (ADAS) and Digital Automotive Simulations. The activity covered in the current paper is the feasibility study, preliminary tests, initial product design and development plan for an EGNOS enabled vehicle probe. The vehicle probe will be used for generating high accuracy, high integrity and ADAS compatible digital maps of roads, employing a multiple passes methodology supported by sophisticated refinement algorithms. Furthermore, the vehicle probe will be equipped with pavement scanning and other data fusion equipment, in order to produce 3D road surface models compatible with standards of road-tire simulation applications. The project was assigned to NIKI Ltd under the 1st Call for Ideas in the frame of the ESA - Greece Task Force.

Diagnostics for the plasma liner experiment.

PubMed

Lynn, A G; Merritt, E; Gilmore, M; Hsu, S C; Witherspoon, F D; Cassibry, J T

2010-10-01

The goal of the Plasma Liner Experiment (PLX) is to explore and demonstrate the feasibility of forming imploding spherical "plasma liners" via merging high Mach number plasma jets to reach peak liner pressures of ∼0.1 Mbar using ∼1.5 MJ of initial stored energy. Such a system would provide HED plasmas for a variety of fundamental HEDLP, laboratory astrophysics, and materials science studies, as well as a platform for experimental validation of rad-hydro and rad-MHD simulations. It could also prove attractive as a potential standoff driver for magnetoinertial fusion. Predicted parameters from jet formation to liner stagnation cover a large range of plasma density and temperature, varying from n(i)∼10(16) cm(-3), T(e)≈T(i)∼1 eV at the plasma gun mouth to n(i)>10(19) cm(-3), T(e)≈T(i)∼0.5 keV at stagnation. This presents a challenging problem for the plasma diagnostics suite which will be discussed.

Inertial Fusion Power Plant Concept of Operations and Maintenance

DOE Office of Scientific and Technical Information (OSTI.GOV)

Anklam, T.; Knutson, B.; Dunne, A. M.

2015-01-15

Parsons and LLNL scientists and engineers performed design and engineering work for power plant pre-conceptual designs based on the anticipated laser fusion demonstrations at the National Ignition Facility (NIF). Work included identifying concepts of operations and maintenance (O&M) and associated requirements relevant to fusion power plant systems analysis. A laser fusion power plant would incorporate a large process and power conversion facility with a laser system and fusion engine serving as the heat source, based in part on some of the systems and technologies advanced at NIF. Process operations would be similar in scope to those used in chemical, oilmore » refinery, and nuclear waste processing facilities, while power conversion operations would be similar to those used in commercial thermal power plants. While some aspects of the tritium fuel cycle can be based on existing technologies, many aspects of a laser fusion power plant presents several important and unique O&M requirements that demand new solutions. For example, onsite recovery of tritium; unique remote material handling systems for use in areas with high radiation, radioactive materials, or high temperatures; a five-year fusion engine target chamber replacement cycle with other annual and multi-year cycles anticipated for major maintenance of other systems, structures, and components (SSC); and unique SSC for fusion target waste recycling streams. This paper describes fusion power plant O&M concepts and requirements, how O&M requirements could be met in design, and how basic organizational and planning issues can be addressed for a safe, reliable, economic, and feasible fusion power plant.« less

Inertial fusion power plant concept of operations and maintenance

NASA Astrophysics Data System (ADS)

Knutson, Brad; Dunne, Mike; Kasper, Jack; Sheehan, Timothy; Lang, Dwight; Anklam, Tom; Roberts, Valerie; Mau, Derek

2015-02-01

Parsons and LLNL scientists and engineers performed design and engineering work for power plant pre-conceptual designs based on the anticipated laser fusion demonstrations at the National Ignition Facility (NIF). Work included identifying concepts of operations and maintenance (O&M) and associated requirements relevant to fusion power plant systems analysis. A laser fusion power plant would incorporate a large process and power conversion facility with a laser system and fusion engine serving as the heat source, based in part on some of the systems and technologies advanced at NIF. Process operations would be similar in scope to those used in chemical, oil refinery, and nuclear waste processing facilities, while power conversion operations would be similar to those used in commercial thermal power plants. While some aspects of the tritium fuel cycle can be based on existing technologies, many aspects of a laser fusion power plant presents several important and unique O&M requirements that demand new solutions. For example, onsite recovery of tritium; unique remote material handling systems for use in areas with high radiation, radioactive materials, or high temperatures; a five-year fusion engine target chamber replacement cycle with other annual and multi-year cycles anticipated for major maintenance of other systems, structures, and components (SSC); and unique SSC for fusion target waste recycling streams. This paper describes fusion power plant O&M concepts and requirements, how O&M requirements could be met in design, and how basic organizational and planning issues can be addressed for a safe, reliable, economic, and feasible fusion power plant.

Modeling of Driver Steering Operations in Lateral Wind Disturbances toward Driver Assistance System

NASA Astrophysics Data System (ADS)

Kurata, Yoshinori; Wada, Takahiro; Kamiji, Norimasa; Doi, Shun'ichi

Disturbances decrease vehicle stability and increase driver's mental and physical workload. Especially unexpected disturbances such as lateral winds have severe effect on vehicle stability and driver's workload. This study aims at building a driver model of steering operations in lateral wind toward developing effective driver assistance system. First, the relationship between the driver's lateral motion and its reactive quick steering behavior is investigated using driving simulator with lateral 1dof motion. In the experiments, four different wind patterns are displayed by the simulator. As the results, strong correlation was found between the driver's head lateral jerk by the lateral disturbance and the angular acceleration of the steering wheel. Then, we build a mathematical model of driver's steering model from lateral disturbance input to steering torque of the reactive quick feed-forward steering based on the experimental results. Finally, validity of the proposed model is shown by comparing the steering torque of experimental results and that of simulation results.

A Context-Aware EEG Headset System for Early Detection of Driver Drowsiness.

PubMed

Li, Gang; Chung, Wan-Young

2015-08-21

Driver drowsiness is a major cause of mortality in traffic accidents worldwide. Electroencephalographic (EEG) signal, which reflects the brain activities, is more directly related to drowsiness. Thus, many Brain-Machine-Interface (BMI) systems have been proposed to detect driver drowsiness. However, detecting driver drowsiness at its early stage poses a major practical hurdle when using existing BMI systems. This study proposes a context-aware BMI system aimed to detect driver drowsiness at its early stage by enriching the EEG data with the intensity of head-movements. The proposed system is carefully designed for low-power consumption with on-chip feature extraction and low energy Bluetooth connection. Also, the proposed system is implemented using JAVA programming language as a mobile application for on-line analysis. In total, 266 datasets obtained from six subjects who participated in a one-hour monotonous driving simulation experiment were used to evaluate this system. According to a video-based reference, the proposed system obtained an overall detection accuracy of 82.71% for classifying alert and slightly drowsy events by using EEG data alone and 96.24% by using the hybrid data of head-movement and EEG. These results indicate that the combination of EEG data and head-movement contextual information constitutes a robust solution for the early detection of driver drowsiness.

A Context-Aware EEG Headset System for Early Detection of Driver Drowsiness

PubMed Central

Li, Gang; Chung, Wan-Young

2015-01-01

Driver drowsiness is a major cause of mortality in traffic accidents worldwide. Electroencephalographic (EEG) signal, which reflects the brain activities, is more directly related to drowsiness. Thus, many Brain-Machine-Interface (BMI) systems have been proposed to detect driver drowsiness. However, detecting driver drowsiness at its early stage poses a major practical hurdle when using existing BMI systems. This study proposes a context-aware BMI system aimed to detect driver drowsiness at its early stage by enriching the EEG data with the intensity of head-movements. The proposed system is carefully designed for low-power consumption with on-chip feature extraction and low energy Bluetooth connection. Also, the proposed system is implemented using JAVA programming language as a mobile application for on-line analysis. In total, 266 datasets obtained from six subjects who participated in a one-hour monotonous driving simulation experiment were used to evaluate this system. According to a video-based reference, the proposed system obtained an overall detection accuracy of 82.71% for classifying alert and slightly drowsy events by using EEG data alone and 96.24% by using the hybrid data of head-movement and EEG. These results indicate that the combination of EEG data and head-movement contextual information constitutes a robust solution for the early detection of driver drowsiness. PMID:26308002

Impact of Connecticut's graduated driver licensing system on teenage motor vehicle crash rates.

PubMed

Rogers, Steven C; Bentley, George C; Campbell, Brendan; Borrup, Kevin; Saleheen, Hassan; Wang, Zhu; Lapidus, Garry

2011-11-01

In response to high rates of teen motor vehicle crashes (MVCs) many states have enacted graduated driver licensing (GDL) systems. GDL delays full licensure and allows beginners to obtain experience under lower risk conditions. The purpose of this study is to evaluate the impact over the past 10 years to determine its effect on teen MVCs. Connecticut MVC data from 1999 to 2008 were analyzed. Percent change (1999 vs. 2008) in MVC rates per 10,000 registered drivers was calculated by age, gender, during the night restriction (11:00 pm and 5:00 am), and MVCs with passengers. Linear regression analysis estimated the decrease of MVC rates each year. The MVC rate decreased by 40% for 16-year-old and 30% for 17-year-old drivers. In comparison, rates among 18-year-old, 19-year-old, 25- to 29-year-old, and 30- to 59-year-old drivers were reduced by 16%, 7%, 8%, and 11%, respectively. The MVC rate for 20- to 24-year-old drivers increased by 1%. During nighttime restricted driving times, MVC rates decreased by 54% among 16-year-old and 49% among 17-year-old drivers. The MVC rate with passengers decreased by 65% for 16-year-old and 53% for 17-year-old drivers. In comparison, rates of nighttime and with passenger MVCs among older drivers were significantly less. Implementation of Connecticut's GDL system has resulted in significant reductions in MVC rates among novice drivers. This analysis provides a method for other states to examine the impact of their GDL system.

Commercial objectives, technology transfer, and systems analysis for fusion power development

NASA Astrophysics Data System (ADS)

Dean, Stephen O.

1988-09-01

Fusion is an inexhaustible source of energy that has the potential for economic commercial applications with excellent safety and environmental characteristics. The primary focus for the fusion energy development program is the generation of central station electricity. Fusion has the potential, however, for many other applications. The fact that a large fraction of the energy released in a DT fusion reaction is carried by high energy neutrons suggests potentially unique applications. In addition, fusion R and D will lead to new products and new markets. Each fusion application must meet certain standards of economic and safety and environmental attractiveness. For this reason, economics on the one hand, and safety and environment and licensing on the other, are the two primary criteria for setting long range commercial fusion objectives. A major function of systems analysis is to evaluate the potential of fusion against these objectives and to help guide the fusion R and D program toward practical applications. The transfer of fusion technology and skills from the national labs and universities to industry is the key to achieving the long range objective of commercial fusion applications.

Commercial objectives, technology transfer, and systems analysis for fusion power development

NASA Technical Reports Server (NTRS)

Dean, Stephen O.

1988-01-01

Fusion is an inexhaustible source of energy that has the potential for economic commercial applications with excellent safety and environmental characteristics. The primary focus for the fusion energy development program is the generation of central station electricity. Fusion has the potential, however, for many other applications. The fact that a large fraction of the energy released in a DT fusion reaction is carried by high energy neutrons suggests potentially unique applications. In addition, fusion R and D will lead to new products and new markets. Each fusion application must meet certain standards of economic and safety and environmental attractiveness. For this reason, economics on the one hand, and safety and environment and licensing on the other, are the two primary criteria for setting long range commercial fusion objectives. A major function of systems analysis is to evaluate the potential of fusion against these objectives and to help guide the fusion R and D program toward practical applications. The transfer of fusion technology and skills from the national labs and universities to industry is the key to achieving the long range objective of commercial fusion applications.

Advanced multivariate data analysis to determine the root cause of trisulfide bond formation in a novel antibody–peptide fusion

PubMed Central

Goldrick, Stephen; Holmes, William; Bond, Nicholas J.; Lewis, Gareth; Kuiper, Marcel; Turner, Richard

2017-01-01

ABSTRACT Product quality heterogeneities, such as a trisulfide bond (TSB) formation, can be influenced by multiple interacting process parameters. Identifying their root cause is a major challenge in biopharmaceutical production. To address this issue, this paper describes the novel application of advanced multivariate data analysis (MVDA) techniques to identify the process parameters influencing TSB formation in a novel recombinant antibody–peptide fusion expressed in mammalian cell culture. The screening dataset was generated with a high‐throughput (HT) micro‐bioreactor system (AmbrTM 15) using a design of experiments (DoE) approach. The complex dataset was firstly analyzed through the development of a multiple linear regression model focusing solely on the DoE inputs and identified the temperature, pH and initial nutrient feed day as important process parameters influencing this quality attribute. To further scrutinize the dataset, a partial least squares model was subsequently built incorporating both on‐line and off‐line process parameters and enabled accurate predictions of the TSB concentration at harvest. Process parameters identified by the models to promote and suppress TSB formation were implemented on five 7 L bioreactors and the resultant TSB concentrations were comparable to the model predictions. This study demonstrates the ability of MVDA to enable predictions of the key performance drivers influencing TSB formation that are valid also upon scale‐up. Biotechnol. Bioeng. 2017;114: 2222–2234. © 2017 The Authors. Biotechnology and Bioengineering Published by Wiley Periodicals, Inc. PMID:28500668

Review of light-ion driver development for inertial fusion energy

NASA Astrophysics Data System (ADS)

Bluhm, H.; Hoppé, P.

2001-05-01

The concept of a light ion beam driver for Inertial Fusion Energy (IFE) is based on multi-terawatt, multi-megavolt pulsed power generators, two-stage ion acceleration and charge neutralised transport. In this paper we discuss the present status for each of these components and identify the main issues for research. Only modest extrapolations from presently available technologies seem necessary for the high voltage pulse generator. The greatest challenge of this approach is the accelerator, which will consist of two stages, the injector and the post-accelerator. Large progress has been made in understanding the physical phenomena occurring in the injector gap. This progress has become possible by new sophisticated diagnostics that allowed detailed temporally and spatially resolved measurements of field and particle densities in the acceleration gap and by relativistic fully electromagnetic PIC-simulation tools, that stimulated analytic models. The conclusions drawn from these studies, namely limiting the ion current density to small enhancements to reduce the beam divergence need still to be verified experimentally. Systematic experimental research on post-acceleration at high power and voltage must aim at a complete understanding of instabilities coupling from the injector to the post-accelerator and at limiting voltages and barriers for the extraction of unwanted ions from plasmas at the injection side. Ultimately the light ion approach requires rep-rateable large area ion sources with ion masses greater than 1 and particle energies around 30 MeV. Although different cleaning protocols were able to reduce the amount of parasitic ions in the Li beam from a LiF field emission source the achievements are still insufficient. A field of common interest between light and heavy ion beam driven fusion is beam transport from the accelerator to the target. Supposedly the most favourable concept for both approaches is self-pinched transport. Experimental evidence for self-pinched transport has recently been achieved in an experiment at NRL. Further experiments are needed to determine the dynamics and magnitude of net current formation, the efficiency of transport and the effect of bunching.

The US ICF Ignition Program and the Inertial Fusion Program

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lindl, J D; Hammel, B A; Logan, B G

2003-07-02

There has been rapid progress in inertial fusion in the past few years. This progress spans the construction of ignition facilities, a wide range of target concepts, and the pursuit of integrated programs to develop fusion energy using lasers, ion beams and z-pinches. Two ignition facilities are under construction (NIF in the U.S. and LMJ in France) and both projects are progressing toward an initial experimental capability. The LIL prototype beamline for LMJ and the first 4 beams of NIF will be available for experiments in 2003. The full 192 beam capability of NIF will be available in 2009 andmore » ignition experiments are expected to begin shortly after that time. There is steady progress in the target science and target fabrication in preparation for indirect drive ignition experiments on NIF. Advanced target designs may lead to 5-10 times more yield than initial target designs. There has also been excellent progress on the science of ion beam and z-pinch driven indirect drive targets. Excellent progress on direct-drive targets has been obtained on the Omega laser at the University of Rochester. This includes improved performance of targets with a pulse shape predicted to result in reduced hydrodynamic instability. Rochester has also obtained encouraging results from initial cryogenic implosions. There is widespread interest in the science of fast ignition because of its potential for achieving higher target gain with lower driver energy and relaxed target fabrication requirements. Researchers from Osaka have achieved outstanding implosion and heating results from the Gekko XII Petawatt facility and implosions suitable for fast ignition have been tested on the Omega laser. A broad based program to develop lasers and ions beams for IFE is under way with excellent progress in drivers, chambers, target fabrication and target injection. KrF and Diode Pumped Solid-State lasers (DPSSL) are being developed in conjunction with drywall chambers and direct drive targets. Induction accelerators for heavy ions are being developed in conjunction with thick-liquid protected wall chambers and indirect-drive targets.« less

Impacts of the driver's bounded rationality on the traffic running cost under the car-following model

NASA Astrophysics Data System (ADS)

Tang, Tie-Qiao; Luo, Xiao-Feng; Liu, Kai

2016-09-01

The driver's bounded rationality has significant influences on the micro driving behavior and researchers proposed some traffic flow models with the driver's bounded rationality. However, little effort has been made to explore the effects of the driver's bounded rationality on the trip cost. In this paper, we use our recently proposed car-following model to study the effects of the driver's bounded rationality on his running cost and the system's total cost under three traffic running costs. The numerical results show that considering the driver's bounded rationality will enhance his each running cost and the system's total cost under the three traffic running costs.

Drunk Driver Testing

NASA Technical Reports Server (NTRS)

1984-01-01

Systems Technology, Inc. developed a technique to study/measure behavioral changes brought on by long term isolation is now being used in a system for determining whether a driver is too drunk to drive. Device is intended to discourage intoxicated drivers from taking to the road by advising them they are in no condition to operate a vehicle. System is being tested experimentally in California.

Emergency Vehicle Alarm System for Deaf Drivers by Using LEDs and Vibration Devices

NASA Astrophysics Data System (ADS)

Kuwahara, Noriaki; Morimoto, Kazunari; Kozuki, Kazumasa; Kawamura, Tomonori

We are developing the emergency vehicle alarm system for deaf drivers by using LEDs and vibration devices. In order to design the alarm for deaf drivers, we have conducted basic experiment in order to evaluate perceptual characteristic on visibility of LED.

Car drivers' perceptions of electronic stability control (ESC) systems.

PubMed

Vadeby, Anna; Wiklund, Mats; Forward, Sonja

2011-05-01

As a way to reduce the number of car crashes different in-car safety devices are being introduced. In this paper one such application is being investigated, namely the electronic stability control system (ESC). The study used a survey method, including 2000 private car drivers (1000 driving a car with ESC and 1000 driving a car without ESC). The main objective was to investigate the effect of ESC on driver behaviour. Results show that drivers report that they drive even more carelessly when they believe that they have ESC, than when they do not. Men are more risk prone than women and young drivers more than older drivers. Using the theory of planned behaviour the results show that attitude, subjective norm and perceived control explain between 62% and 67% of driver's variation of intentions to take risks. When descriptive norm was added to the model a small but statistically significant increase was found. The study also shows that more than 35% erroneously believe that their car is equipped with an ESC system. These findings may suggest that driver behaviour could reduce the positive effect ESC has on accidents. It also shows that drivers who purchase a new car are not well informed about what kind of safety devices the car is equipped with. These findings highlight the need for more targeted information to drivers. Copyright © 2010 Elsevier Ltd. All rights reserved.

Effects of different blood alcohol concentrations and post-alcohol impairment on driving behavior and task performance.

PubMed

Liu, Yung-Ching; Ho, Chin Heng

2010-08-01

A study using simulator methodology was conducted to investigate the effects of (1) different blood alcohol concentrations (BAC) of 0, 0.05, 0.08, and 0.10 percent and (2) post-alcohol impairment (where BAC approximately 0%) on driving behavior and subsidiary cognitive task performance. Two driving sessions were investigated, that is, drunk driving and post-alcohol driving, with each requiring approximately 20 min of driving. In addition to driving safely, participants were instructed to perform the critical flicker fusion (CFF) test and completed the NASA-TLX mental workload questionnaire. Eight licensed drivers (6 males, 2 females) participated in this 2 (road complexities) x 2 (simulated driving sessions) x 4 (levels of BAC) within-subjects experiment. The study revealed that higher BAC levels were associated with lower performing driving behavior. The driver's mental workload reached the highest values in the post-alcohol session. In terms of tasks involving divided attention, the traffic sign distance estimation showed significant deterioration with increased BAC levels. The relationship between drunk-driving behavior and alcohol dosage was supported in this study. Noticeably, no significant difference was found between drunk driving and post-alcohol driving, indicating that even in the post-alcohol situation, the impairment still remained significant enough to jeopardize traffic safety as much as it does in the case of drunk driving. In real-life situations, adopting a rest-time strategy to avoid post-alcohol impairment effects may not be the most appropriate solution by drivers; rather, drivers should be given some tests to verify the probability of post-alcohol effects on driving.

Comprehensive investigation of oncogenic driver mutations in Chinese non-small cell lung cancer patients.

PubMed

Wang, Rui; Zhang, Yang; Pan, Yunjian; Li, Yuan; Hu, Haichuan; Cai, Deng; Li, Hang; Ye, Ting; Luo, Xiaoyang; Zhang, Yiliang; Li, Bin; Shen, Lei; Sun, Yihua; Chen, Haiquan

2015-10-27

To determine the frequency of driver mutations in Chinese non-small cell lung cancer (NSCLC) patients. Comprehensive mutational analysis was performed in 1356 lung adenocarcinoma, 503 squamous cell carcinoma, 57 adenosquamous lung carcinoma, 19 large cell carcinoma and 8 sarcomatoid carcinoma. The effect of EGFR tyrosine kinase inhibitors (TKIs) on EGFR-mutated lung adenocarcinoma patients after disease recurrence was investigated. Mutations in EGFR kinase domain, HER2 kinase domain, KRAS, BRAF, ALK, ROS1 and RET were mutually exclusive. In lung adenocarcinoma cases "pan-negative" for the seven above-mentioned driver mutations, we also detected two oncogenic EGFR extracellular domain mutations (A289D and R324L), two HER2 extracellular and transmembrane domain mutations (S310Y and V659E), one ARAF S214C mutation and two CD74-NRG1 fusions. Six (1.2%) FGFR3 activating mutations were identified in lung squamous cell carcinoma (five S249C and one R248C). There were three (15.8%) EGFR mutations and four (21.1%) KRAS mutations in large cell carcinoma. Three (37.5%) KRAS mutations were detected in sarcomatoid carcinoma. In EGFR-mutated lung adenocarcinoma patients who experienced disease recurrence, treatment with EGFR TKIs was an independent predictor of better overall survival (HR = 0.299, 95% CI: 0.172-0.519, P < 0.001). We determined the frequency of driver mutations in a large series of Chinese NSCLC patients. EGFR TKIs might improve the survival outcomes of EGFR-mutated lung adenocarcinoma patients who experienced disease recurrence.

Comprehensive Characterization of Oncogenic Drivers in Asian Lung Adenocarcinoma.

PubMed

Li, Shiyong; Choi, Yoon-La; Gong, Zhuolin; Liu, Xiao; Lira, Maruja; Kan, Zhengyan; Oh, Ensel; Wang, Jian; Ting, Jason C; Ye, Xiangsheng; Reinhart, Christoph; Liu, Xiaoqiao; Pei, Yunfei; Zhou, Wei; Chen, Ronghua; Fu, Shijun; Jin, Gang; Jiang, Awei; Fernandez, Julio; Hardwick, James; Kang, Min Woong; I, Hoseok; Zheng, Hancheng; Kim, Jhingook; Mao, Mao

2016-12-01

The incidence rate of lung adenocarcinoma (LUAD), the predominant histological subtype of lung cancer, is elevated in Asians, particularly in female nonsmokers. The mutation patterns in LUAD in Asians might be distinct from those in LUAD in whites. We profiled 271 resected LUAD tumors (mainly stage I) to characterize the genomic landscape of LUAD in Asians with a focus on female nonsmokers. Mutations in EGFR, KRAS, erb-b2 receptor tyrosine kinase 2 gene (ERBB2), and BRAF; gene fusions involving anaplastic lymphoma receptor tyrosine kinase gene (ALK), ROS1, and ret proto-oncogene (RET); and Met Proto-Oncogene Tyrosine Kinase (MET) exon 14 skipping were the major drivers in LUAD in Asians, exhibiting mutually exclusive and differing prevalence from those reported in studies of LUAD in non-Asians. In addition, we identified a novel mutational signature of XNX (the mutated base N in the middle flanked by two identical bases at the 5' and 3' positions) that was overrepresented in LUAD tumors in nonsmokers and negatively correlated with the overall mutational frequency. In this cohort, approximately 85% of individuals have known driver mutations (EGFR 59.4%, KRAS 7.4%, ALK 7.4%, ERBB2 2.6%, ROS1 2.2%, RET 2.2%, MET 1.8%, BRAF 1.1%, and NRAS 0.4%). Seventy percent of smokers and 90% of nonsmokers had defined oncogenic drivers matching the U.S. Food and Drug Administration-approved targeted therapies. Copyright © 2016 International Association for the Study of Lung Cancer. Published by Elsevier Inc. All rights reserved.

An Investigation for Ground State Features of Some Structural Fusion Materials

NASA Astrophysics Data System (ADS)

Aytekin, H.; Tel, E.; Baldik, R.; Aydin, A.

2011-02-01

Environmental concerns associated with fossil fuels are creating increased interest in alternative non-fossil energy sources. Nuclear fusion can be one of the most attractive sources of energy from the viewpoint of safety and minimal environmental impact. When considered in all energy systems, the requirements for performance of structural materials in a fusion reactor first wall, blanket or diverter, are arguably more demanding or difficult than for other energy system. The development of fusion materials for the safety of fusion power systems and understanding nuclear properties is important. In this paper, ground state properties for some structural fusion materials as 27Al, 51V, 52Cr, 55Mn, and 56Fe are investigated using Skyrme-Hartree-Fock method. The obtained results have been discussed and compared with the available experimental data.

LLE review. Quarterly report, January 1994--March 1994, Volume 58

DOE Office of Scientific and Technical Information (OSTI.GOV)

Simon, A.

1994-07-01

This volume of the LLE Review, covering the period Jan - Mar 1994, contains articles on backlighting diagnostics; the effect of electron collisions on ion-acoustic waves and heat flow; using PIC code simulations for analysis of ultrashort laser pulses interacting with solid targets; creating a new instrument for characterizing thick cryogenic layers; and a description of a large-aperture ring amplifier for laser-fusion drivers. Three of these articles - backlighting diagnostics; characterizing thick cryogenic layers; and large-aperture ring amplifier - are directly related to the OMEGA Upgrade, now under construction. Separate abstracts have been prepared for articles from this report.

Foil cooling for rep-rated electron beam pumped KrF lasers

NASA Astrophysics Data System (ADS)

Giuliani, J. L.; Hegeler, F.; Sethian, J. D.; Wolford, M. F.; Myers, M. C.; Abdel-Khalik, S.; Sadowski, D.; Schoonover, K.; Novak, V.

2006-06-01

In rep-rated electron beam pumped lasers the foil separating the vacuum diode from the laser gas is subject to repeated heating due to partial beam stopping. Three cooling methods are examined for the Electra KrF laser at the Naval Research Laboratory (NRL). Foil temperature measurements for convective cooling by the recirculating laser gas and by spray mist cooling are reported, along with estimates for thermal conductive foil cooling to the hibachi ribs. Issues on the application of each of these approaches to laser drivers in a fusion power plant are noted. Work supported by DOE/NNSA.

Safety and environmental constraints on space applications of fusion energy

NASA Technical Reports Server (NTRS)

Roth, J. Reece

1990-01-01

Some of the constraints are examined on fusion reactions, plasma confinement systems, and fusion reactors that are intended for such space related missions as manned or unmanned operations in near earth orbit, interplanetary missions, or requirements of the SDI program. Of the many constraints on space power and propulsion systems, those arising from safety and environmental considerations are emphasized since these considerations place severe constraints on some fusion systems and have not been adequately treated in previous studies.

Effectiveness of Ford's belt reminder system in increasing seat belt use

PubMed Central

Williams, A; Wells, J; Farmer, C

2002-01-01

Objectives: The study investigated the effectiveness in increasing seat belt use of Ford's belt reminder system, a supplementary system that provides intermittent flashing lights and chimes for five minutes if drivers are not belted. Methods: Seat belt use of drivers in relatively new cars with and without the reminder system was unobtrusively observed as vehicles were brought to dealerships for service. Results: Overall use rates were estimated at 71% for drivers in vehicles without the reminder system and 76% for drivers in vehicles with belt reminders (p<0.01). Conclusions: Seat belt use is relatively low in the United States. The present study showed that vehicle based reminder systems can be at least modestly effective in increasing belt use, which may encourage further development of such systems. PMID:12460965

Automatic Fatigue Detection of Drivers through Yawning Analysis

NASA Astrophysics Data System (ADS)

Azim, Tayyaba; Jaffar, M. Arfan; Ramzan, M.; Mirza, Anwar M.

This paper presents a non-intrusive fatigue detection system based on the video analysis of drivers. The focus of the paper is on how to detect yawning which is an important cue for determining driver's fatigue. Initially, the face is located through Viola-Jones face detection method in a video frame. Then, a mouth window is extracted from the face region, in which lips are searched through spatial fuzzy c-means (s-FCM) clustering. The degree of mouth openness is extracted on the basis of mouth features, to determine driver's yawning state. If the yawning state of the driver persists for several consecutive frames, the system concludes that the driver is non-vigilant due to fatigue and is thus warned through an alarm. The system reinitializes when occlusion or misdetection occurs. Experiments were carried out using real data, recorded in day and night lighting conditions, and with users belonging to different race and gender.

Affordable non-traditional source data mining for context assessment to improve distributed fusion system robustness

NASA Astrophysics Data System (ADS)

Bowman, Christopher; Haith, Gary; Steinberg, Alan; Morefield, Charles; Morefield, Michael

2013-05-01

This paper describes methods to affordably improve the robustness of distributed fusion systems by opportunistically leveraging non-traditional data sources. Adaptive methods help find relevant data, create models, and characterize the model quality. These methods also can measure the conformity of this non-traditional data with fusion system products including situation modeling and mission impact prediction. Non-traditional data can improve the quantity, quality, availability, timeliness, and diversity of the baseline fusion system sources and therefore can improve prediction and estimation accuracy and robustness at all levels of fusion. Techniques are described that automatically learn to characterize and search non-traditional contextual data to enable operators integrate the data with the high-level fusion systems and ontologies. These techniques apply the extension of the Data Fusion & Resource Management Dual Node Network (DNN) technical architecture at Level 4. The DNN architecture supports effectively assessment and management of the expanded portfolio of data sources, entities of interest, models, and algorithms including data pattern discovery and context conformity. Affordable model-driven and data-driven data mining methods to discover unknown models from non-traditional and `big data' sources are used to automatically learn entity behaviors and correlations with fusion products, [14 and 15]. This paper describes our context assessment software development, and the demonstration of context assessment of non-traditional data to compare to an intelligence surveillance and reconnaissance fusion product based upon an IED POIs workflow.

Engineering of the Magnetized Target Fusion Propulsion System

NASA Technical Reports Server (NTRS)

Statham, G.; White, S.; Adams, R. B.; Thio, Y. C. F.; Santarius, J.; Alexander, R.; Chapman, J.; Fincher, S.; Philips, A.; Polsgrove, T.

2003-01-01

Engineering details are presented for a magnetized target fusion (MTF) propulsion system designed to support crewed missions to the outer solar system. Basic operation of an MTF propulsion system is introduced. Structural, thermal, radiation-management and electrical design details are presented. The propellant storage and supply system design is also presented. A propulsion system mass estimate and associated performance figures are given. The advantages of helium-3 as a fusion fuel for an advanced MTF system are discussed.

Toward best practice in Human Machine Interface design for older drivers: A review of current design guidelines.

PubMed

Young, K L; Koppel, S; Charlton, J L

2017-09-01

Older adults are the fastest growing segment of the driving population. While there is a strong emphasis for older people to maintain their mobility, the safety of older drivers is a serious community concern. Frailty and declines in a range of age-related sensory, cognitive, and physical impairments can place older drivers at an increased risk of crash-related injuries and death. A number of studies have indicated that in-vehicle technologies such as Advanced Driver Assistance Systems (ADAS) and In-Vehicle Information Systems (IVIS) may provide assistance to older drivers. However, these technologies will only benefit older drivers if their design is congruent with the complex needs and diverse abilities of this driving cohort. The design of ADAS and IVIS is largely informed by automotive Human Machine Interface (HMI) guidelines. However, it is unclear to what extent the declining sensory, cognitive and physical capabilities of older drivers are addressed in the current guidelines. This paper provides a review of key current design guidelines for IVIS and ADAS with respect to the extent they address age-related changes in functional capacities. The review revealed that most of the HMI guidelines do not address design issues related to older driver impairments. In fact, in many guidelines driver age and sensory cognitive and physical impairments are not mentioned at all and where reference is made, it is typically very broad. Prescriptive advice on how to actually design a system so that it addresses the needs and limitations of older drivers is not provided. In order for older drivers to reap the full benefits that in-vehicle technology can afford, it is critical that further work establish how older driver limitations and capabilities can be supported by the system design process, including their inclusion into HMI design guidelines. Copyright © 2016 Elsevier Ltd. All rights reserved.

Inverted micellar intermediates and the transitions between lamellar, cubic, and inverted hexagonal lipid phases. II. Implications for membrane-membrane interactions and membrane fusion.

PubMed Central

Siegel, D P

1986-01-01

Results of a kinetic model of thermotropic L alpha----HII phase transitions are used to predict the types and order-of-magnitude rates of interactions between unilamellar vesicles that can occur by intermediates in the L alpha----HII phase transition. These interactions are: outer monolayer lipid exchange between vesicles; vesicle leakage subsequent to aggregation; and (only in systems with ratios of L alpha and HII phase structural dimensions in a certain range or with unusually large bilayer lateral compressibilities) vesicle fusion with retention of contents. It was previously proposed that inverted micellar structures mediate membrane fusion. These inverted micellar structures are thought to form in all systems with such transitions. However, I show that membrane fusion probably occurs via structures that form from these inverted micellar intermediates, and that fusion should occur in only a sub-set of lipid systems that can adopt the HII phase. For single-component phosphatidylethanolamine (PE) systems with thermotropic L alpha----HII transitions, lipid exchange should be observed starting at temperatures several degrees below TH and at all higher temperatures, where TH is the L alpha----HII transition temperature. At temperatures above TH, the HII phase forms between apposed vesicles, and eventually ruptures them (leakage). In most single-component PE systems, fusion via L alpha----HII transition intermediates should not occur. This is the behavior observed by Bentz, Ellens, Lai, Szoka, et al. in PE vesicle systems. Fusion is likely to occur under circumstances in which multilamellar samples of lipid form the so-called "inverted cubic" or "isotropic" phase. This is as observed in the mono-methyl DOPE system (Ellens, H., J. Bentz, and F. C. Szoka. 1986. Fusion of phosphatidylethanolamine containing liposomes and the mechanism of the L alpha-HII phase transition. Biochemistry. In press.) In lipid systems with L alpha----HII transitions driven by cation binding (e.g., Ca2+-cardiolipin), fusion should be more frequent than in thermotropic systems. PMID:3719075

An empirical assessment of driver motivation and emotional states in perceived safety margins under varied driving conditions.

PubMed

Zhang, Yu; Kaber, David B

2013-01-01

Motivation models in driving behaviour postulate that driver motives and emotional states dictate risk tolerance under various traffic conditions. The present study used time and driver performance-based payment systems to manipulate motivation and risk-taking behaviour. Ten participants drove to a predefined location in a simulated driving environment. Traffic patterns (density and velocity) were manipulated to cause driver behaviour adjustments due to the need to conform with the social norms of the roadway. The driving environment complexity was investigated as a mediating factor in risk tolerance. Results revealed the performance-based payment system to closely relate to risk-taking behaviour as compared with the time-based payment system. Drivers conformed with social norms associated with specific traffic patterns. Higher roadway complexity led to a more conservative safety margins and speeds. This research contributes to the further development of motivational models of driver behaviour. This study provides empirical justification for two motivation factors in driver risk-taking decisions, including compliance with social norm and emotions triggered by incentives. Environment complexity was identified as a mediating factor in motivational behaviour model. This study also recommended safety margin measures sensitive to changes in driver risk tolerance.

Myoblast fusion: lessons from flies and mice

PubMed Central

Abmayr, Susan M.; Pavlath, Grace K.

2012-01-01

The fusion of myoblasts into multinucleate syncytia plays a fundamental role in muscle function, as it supports the formation of extended sarcomeric arrays, or myofibrils, within a large volume of cytoplasm. Principles learned from the study of myoblast fusion not only enhance our understanding of myogenesis, but also contribute to our perspectives on membrane fusion and cell-cell fusion in a wide array of model organisms and experimental systems. Recent studies have advanced our views of the cell biological processes and crucial proteins that drive myoblast fusion. Here, we provide an overview of myoblast fusion in three model systems that have contributed much to our understanding of these events: the Drosophila embryo; developing and regenerating mouse muscle; and cultured rodent muscle cells. PMID:22274696

Real-time sensor validation and fusion for distributed autonomous sensors

NASA Astrophysics Data System (ADS)

Yuan, Xiaojing; Li, Xiangshang; Buckles, Bill P.

2004-04-01

Multi-sensor data fusion has found widespread applications in industrial and research sectors. The purpose of real time multi-sensor data fusion is to dynamically estimate an improved system model from a set of different data sources, i.e., sensors. This paper presented a systematic and unified real time sensor validation and fusion framework (RTSVFF) based on distributed autonomous sensors. The RTSVFF is an open architecture which consists of four layers - the transaction layer, the process fusion layer, the control layer, and the planning layer. This paradigm facilitates distribution of intelligence to the sensor level and sharing of information among sensors, controllers, and other devices in the system. The openness of the architecture also provides a platform to test different sensor validation and fusion algorithms and thus facilitates the selection of near optimal algorithms for specific sensor fusion application. In the version of the model presented in this paper, confidence weighted averaging is employed to address the dynamic system state issue noted above. The state is computed using an adaptive estimator and dynamic validation curve for numeric data fusion and a robust diagnostic map for decision level qualitative fusion. The framework is then applied to automatic monitoring of a gas-turbine engine, including a performance comparison of the proposed real-time sensor fusion algorithms and a traditional numerical weighted average.

Performance Evaluation of Fusing Protected Fingerprint Minutiae Templates on the Decision Level

PubMed Central

Yang, Bian; Busch, Christoph; de Groot, Koen; Xu, Haiyun; Veldhuis, Raymond N. J.

2012-01-01

In a biometric authentication system using protected templates, a pseudonymous identifier is the part of a protected template that can be directly compared. Each compared pair of pseudonymous identifiers results in a decision testing whether both identifiers are derived from the same biometric characteristic. Compared to an unprotected system, most existing biometric template protection methods cause to a certain extent degradation in biometric performance. Fusion is therefore a promising way to enhance the biometric performance in template-protected biometric systems. Compared to feature level fusion and score level fusion, decision level fusion has not only the least fusion complexity, but also the maximum interoperability across different biometric features, template protection and recognition algorithms, templates formats, and comparison score rules. However, performance improvement via decision level fusion is not obvious. It is influenced by both the dependency and the performance gap among the conducted tests for fusion. We investigate in this paper several fusion scenarios (multi-sample, multi-instance, multi-sensor, multi-algorithm, and their combinations) on the binary decision level, and evaluate their biometric performance and fusion efficiency on a multi-sensor fingerprint database with 71,994 samples. PMID:22778583

Fusion for Space Propulsion

NASA Technical Reports Server (NTRS)

Thio, Y. C. Francis; Schafer, Charles (Technical Monitor)

2001-01-01

There is little doubt that humans will attempt to explore and develop the solar system in this century. A large amount of energy will be required for accomplishing this. The need for fusion propulsion is discussed. For a propulsion system, there are three important thermodynamical attributes: (1) The absolute amount of energy available, (2) the propellant exhaust velocity, and (3) the jet power per unit mass of the propulsion system (specific power). For human exploration and development of the solar system, propellant exhaust velocity in excess of 100 km/s and specific power in excess of 10 kW/kg are required. Chemical combustion can produce exhaust velocity up to about 5 km/s. Nuclear fission processes typically result in producing energy in the form of heat that needs to be manipulated at temperatures limited by materials to about 2,800 K. Using the energy to heat a hydrogen propellant increases the exhaust velocity by only a factor of about two. Alternatively the energy can be converted into electricity which is then used to accelerate particles to high exhaust velocity. The necessary power conversion and conditioning equipment, however, increases the mass of the propulsion system for the same jet power by more than two orders of magnitude over chemical system, thus greatly limits the thrust-to-weight ratio attainable. The principal advantage of the fission process is that its development is relatively mature and is available right now. If fusion can be developed, fusion appears to have the best of all worlds in terms of propulsion - it can provide the absolute amount, the propellant exhaust velocity, and the high specific jet power. An intermediate step towards pure fusion propulsion is a bimodal system in which a fission reactor is used to provide some of the energy to drive a fusion propulsion unit. The technical issues related to fusion for space propulsion are discussed. The technical priorities for developing and applying fusion for propulsion are somewhat different from those for terrestrial electrical power generation. Thus fusion schemes that are initially attractive for electrical power generation might not necessarily be attractive also for propulsion and vice versa, though the underlying fusion science and engineering enjoy much overlap. Parallel efforts to develop these qualitatively differently fusion schemes for the two applications could benefit greatly from each other due to the synergy in the underlying physics and engineering. Pulsed approaches to fusion have not been explored to the same degree as steady-state or long-pulse approaches to fusion in the fusion power research program. The concerns early on were several. One was that the pulsed power components might not have the service lifetimes meeting the requirements of a practical power generating plant. Another was that, for many pulsed fusion schemes, it was not clear whether the destruction of hardware per pulse could be minimized or eliminated or recycled to such an extent as to make economical electrical power generation feasible, Significant development of the underlying pulsed power component technologies have occurred in the last two decades because of defense and other energy requirements. The state of development of the pulsed power technologies are sufficiently advanced now to make it compelling to visit or re-visit pulsed fusion approaches for application to propulsion where the cost of energy is not so demanding a factor as in the case of terrestrial power application. For propulsion application, the overall mass of the fusion system is the critical factor. Producing fusion reactions require extreme states of matter. Conceptually, these extreme states of matter are more readily realizable in the pulsed states, at least within appropriate bounds, than in the steady states. Significant saving in system mass may result in such systems. Magnetic fields are effective in confining plasma energy, whereas inertial compression is an effective way of heating and containing the plasma. Intensive research in developing magnetic energy containment and inertial plasma compression are being pursued in distinctively different fusion experiments in the terrestrial fusion power program. Fusion schemes that attempt to combine the favorable attributes of these two aspects into one single integrated fusion scheme appear to have benefits that are worth exploring for propulsion application.

A Concept for Continuous Monitoring that Reduces Redundancy in Information Assurance Processes

DTIC Science & Technology

2011-09-01

System.out.println(“Driver loaded”); String url=“jdbc:postgresql://localhost/IAcontrols”; String user = “ postgres ”; String pwd... postgres ”; Connection DB_mobile_conn = DriverManager.getConnection(url,user,pwd); System.out.println(“Database Connect ok...user = “ postgres ”; String pwd = “ postgres ”; Connection DB_mobile_conn = DriverManager.getConnection(url,user,pwd); System.out.println

Cost effectiveness of EML4-ALK fusion testing and first-line crizotinib treatment for patients with advanced ALK-positive non-small-cell lung cancer.

PubMed

Djalalov, Sandjar; Beca, Jaclyn; Hoch, Jeffrey S; Krahn, Murray; Tsao, Ming-Sound; Cutz, Jean-Claude; Leighl, Natasha B

2014-04-01

ALK-targeted therapy with crizotinib offers significant improvement in clinical outcomes for the treatment of EML4-ALK fusion-positive non-small-cell lung cancer (NSCLC). We estimated the cost effectiveness of EML4-ALK fusion testing in combination with targeted first-line crizotinib treatment in Ontario. A cost-effectiveness analysis was conducted using a Markov model from the Canadian Public health (Ontario) perspective and a lifetime horizon in patients with stage IV NSCLC with nonsquamous histology. Transition probabilities and mortality rates were calculated from the Ontario Cancer Registry and Cancer Care Ontario New Drug Funding Program (CCO NDFP). Costs were obtained from the Ontario Case Costing Initiative, CCO NDFP, University Health Network, and literature. Molecular testing with first-line targeted crizotinib treatment in the population with advanced nonsquamous NSCLC resulted in a gain of 0.011 quality-adjusted life-years (QALYs) compared with standard care. The incremental cost was Canadian $2,725 per patient, and the incremental cost-effectiveness ratio (ICER) was $255,970 per QALY gained. Among patients with known EML4-ALK-positive advanced NSCLC, first-line crizotinib therapy provided 0.379 additional QALYs, cost an additional $95,043 compared with standard care, and produced an ICER of $250,632 per QALY gained. The major driver of cost effectiveness was drug price. EML4-ALK fusion testing in stage IV nonsquamous NSCLC with crizotinib treatment for ALK-positive patients is not cost effective in the setting of high drug costs and a low biomarker frequency in the population.

Mutations of the EGFR, K-ras, EML4-ALK, and BRAF genes in resected pathological stage I lung adenocarcinoma.

PubMed

Ohba, Taro; Toyokawa, Gouji; Osoegawa, Atsushi; Hirai, Fumihiko; Yamaguchi, Masafumi; Taguchi, Ken-Ichi; Seto, Takashi; Takenoyama, Mitsuhiro; Ichinose, Yukito; Sugio, Kenji

2016-09-01

The EGFR, K-ras, EML4-ALK, and BRAF genes are oncogenic drivers of lung adenocarcinoma. We conducted this study to analyze the mutations of these genes in stage I adenocarcinoma. The subjects of this retrospective study were 256 patients with resected stage I lung adenocarcinoma. We analyzed mutations of the EGFR, K-ras, and BRAF genes, and the EML4-ALK fusion gene. We also assessed disease-free survival (DFS) to evaluate the prognostic value and overall survival (OS) to evaluate the predictive value of treatment after recurrence. Mutations of the EGFR, K-ras, EML4-ALK, and BRAF genes were detected in 120 (46.8 %), 14 (5.5 %), 6 (2.3 %), and 2 (0.8 %) of the 256 tumors. Two tumors had double mutations (0.8 %). The incidence of EGFR mutations was significantly higher in women than in men. The EML4-ALK fusion gene was detected only in younger patients. The DFS and OS of the K-ras mutant group were significantly worse than those of the EGFR mutant group, the EML4-ALK fusion gene group, and the wild-type group. Six of the seven patients with the EML4-ALK fusion gene are still alive without recurrent disease. In patients with stage I adenocarcinoma, mutation of the K-ras gene was a poor prognostic factor for recurrence. The presence of a mutation of the EGFR or EML4-ALK gene was not a prognostic factor.

Axial magnetic field injection in magnetized liner inertial fusion

NASA Astrophysics Data System (ADS)

Gourdain, P.-A.; Adams, M. B.; Davies, J. R.; Seyler, C. E.

2017-10-01

MagLIF is a fusion concept using a Z-pinch implosion to reach thermonuclear fusion. In current experiments, the implosion is driven by the Z-machine using 19 MA of electrical current with a rise time of 100 ns. MagLIF requires an initial axial magnetic field of 30 T to reduce heat losses to the liner wall during compression and to confine alpha particles during fusion burn. This field is generated well before the current ramp starts and needs to penetrate the transmission lines of the pulsed-power generator, as well as the liner itself. Consequently, the axial field rise time must exceed hundreds of microseconds. Any coil capable of being submitted to such a field for that length of time is inevitably bulky. The space required to fit the coil near the liner, increases the inductance of the load. In turn, the total current delivered to the load decreases since the voltage is limited by driver design. Yet, the large amount of current provided by the Z-machine can be used to produce the required 30 T field by tilting the return current posts surrounding the liner, eliminating the need for a separate coil. However, the problem now is the field penetration time, across the liner wall. This paper discusses why skin effect arguments do not hold in the presence of resistivity gradients. Numerical simulations show that fields larger than 30 T can diffuse across the liner wall in less than 60 ns, demonstrating that external coils can be replaced by return current posts with optimal helicity.

Estimating the over-involvement of suspended, revoked, and unlicensed drivers as at-fault drivers in California fatal crashes.

PubMed

Brar, Sukhvir S

2014-09-01

Quasi-induced exposure analysis was used to estimate annual fatal crash involvement rates for validly licensed, suspended or revoked (S/R), and unlicensed drivers in California from 1987 through 2009 using fatal crash data obtained from the National Highway Traffic Safety Administration's Fatality Analysis Reporting System and crash culpability determinations from the California Highway Patrol's Statewide Integrated Traffic Records System. Although there was some year-to-year fluctuation in the annual estimates, S/R and unlicensed drivers were over-involved as at-fault drivers in fatal crashes during every year of the 23-year time period relative to validly licensed drivers. The fatal crash involvement ratios combined across all years were 0.86 for validly licensed drivers, 2.23 for S/R drivers, and 2.34 for unlicensed drivers. Hence, compared to validly licensed drivers, the odds of being at-fault for a fatal crash were 160% higher for S/R drivers (involvement ratio=2.60) and 173% higher for unlicensed drivers (involvement ratio=2.73). The excess risks of S/R and unlicensed drivers are somewhat lower than estimates found in a prior study using the same technique, but the results nonetheless provide evidence that S/R and unlicensed drivers are much more hazardous on the road than are validly licensed drivers and emphasize the importance of using strong countermeasures-including vehicle impoundment-to reduce their high crash risk. These findings support interventions to help reduce driving among S/R and unlicensed drivers. Published by Elsevier Ltd.

On an efficient and effective intelligent transportation system (ITS) safety and traffic efficiency application with corresponding driver behavior

NASA Astrophysics Data System (ADS)

Ekedebe, Nnanna; Yu, Wei; Lu, Chao

2015-06-01

Driver distraction could result in safety compromises attributable to distractions from in-vehicle equipment usage [1]. The effective design of driver-vehicle interfaces (DVIs) and other human-machine interfaces (HMIs) together with their usability, and accessibility while driving become important [2]. Driving distractions can be classified as: visual distractions (any activity that takes your eyes away from the road), cognitive distraction (any activity that takes your mind away from the course of driving), and manual distractions (any activity that takes your hands away from the steering wheel [2]). Besides, multitasking during driving is a distractive activity that can increase the risks of vehicular accidents. To study the driver's behaviors on the safety of transportation system, using an in-vehicle driver notification application, we examined the effects of increasing driver distraction levels on the evaluation metrics of traffic efficiency and safety by using two types of driver models: young drivers (ages 16-25 years) and middle-age drivers (ages 30-45 years). Our evaluation data demonstrates that as a drivers distraction level is increased, less heed is given to change route directives from the in-vehicle on-board unit (OBU) using textual, visual, audio, and haptic notifications. Interestingly, middle-age drivers proved more effective/resilient in mitigating the negative effects of driver distraction over young drivers [2].

Driver Distraction with Wireless Telecommunications and Route Guidance Systems

DOT National Transportation Integrated Search

2000-07-01

Concerns have been raised in recent years about the distraction potential of Intelligent Transportation Systems (ITS) technologies including driver : information systems such as route navigation systems. The research described in this report had the ...

DOE Office of Scientific and Technical Information (OSTI.GOV)

Friedman, A; Kwan, J

Earlier this year, the U.S. Department of Energy Office of Fusion Energy Sciences approved the NDCX-II project, a second-generation Neutralized Drift Compression eXperiment. NDCX-II is a collaborative effort of scientists and engineers from Lawrence Berkeley National Laboratory (LBNL), Lawrence Livermore National Laboratory (LLNL), and the Princeton Plasma Physics Laboratory (PPPL), in a formal collaboration known as the Virtual National Laboratory for Heavy Ion Fusion Science (HIFS-VNL). Supported by $11 M of funding from the American Recovery and Reinvestment Act, construction at LBNL commenced in July of 2009, with completion anticipated in March of 2012. Applications of this facility will includemore » studies of: the basic physics of the poorly understood 'warm dense matter' regime of temperatures around 1 eV and densities near solid, using uniform, volumetric ion heating of thin foil targets; ion energy coupling into an ablating plasma (such as that which occurs in an inertial fusion target) using beams with time-varying kinetic energy; space-charge-dominated ion beam dynamics; and beam focusing and pulse compression in neutralizing plasma. The machine will complement facilities at GSI in Darmstadt, Germany, but will employ lower ion kinetic energies and commensurately shorter stopping ranges in matter. Much of this research will contribute directly toward the collaboration's ultimate goal of electric power production via heavy-ion beam-driven inertial confinement fusion ('Heavy-Ion Fusion', or HIF). In inertial fusion, a target containing fusion fuel is heated by energetic 'driver' beams, and undergoes a miniature thermonuclear explosion. Currently the largest U.S. research program in inertial confinement is at Livermore's National Ignition Facility (NIF), a multibillion-dollar, stadium-sized laser facility optimized for studying physics issues relevant to nuclear stockpile stewardship. Nonetheless, NIF is expected to establish the fundamental feasibility of fusion ignition on the laboratory scale, and thus advance this approach to fusion energy. Heavy ion accelerators have a number of attributes (such as efficiency, longevity, and use of magnetic fields for final focusing) that make them attractive candidates as Inertial Fusion energy (IFE) drivers As with LBNL's existing NDCX-I, the new machine will produce short ion pulses using the technique of neutralized drift compression. A head-to-tail velocity gradient is imparted to the beam, which then shortens as it drifts in neutralizing plasma that suppresses space-charge forces. NDCX-II will make extensive use of induction cells and other hardware from the decommissioned ATA facility at LLNL. Figure (1) shows the layout of the facility, to be sited in LBNL's Building 58 alongside the existing NDCX-I apparatus. This second-generation facility represents a significant upgrade from the existing NDCX-I. It will be extensible and reconfigurable; in the configuration that has received the most emphasis, each NDCX-II pulse will deliver 30 nC of ions at 3 MeV into a mm-scale spot onto a thin-foil target. Pulse compression to {approx} 1 ns occurs in the accelerator as well as in the drift compression line; the beam is manipulated using suitably tailored voltage waveforms in the accelerating gaps. NDCX-II employs novel beam dynamics. To use the 200 kV Blumlein power supplies from ATA (blue cylinders in the figure), the pulse duration must first be reduced to less than 70 ns. This shortening is accomplished in an initial stage of non-neutral drift compression, downstream of the injector and the first few induction cells. The compression is sufficiently rapid that fewer than ten long-pulse waveform generators are needed, with Blumleins powering the rest of the acceleration. Extensive simulation studies have enabled an attractive physics design; these employ both a new 1-D code (ASP) and the VNL's workhorse 2-D/3-D code Warp. Snapshots from a simulation movie (available online) appear in Fig. 2. Studies on a dedicated test stand are quantifying the performance of the ATA hardware and of pulsed solenoids that will provide transverse beam confinement (ions require much stronger fields than the electrons accelerated by ATA). For more information, see the recent article in the Berkeley Lab News and references therein. Joe Kwan is the NDCX-II project manager and Alex Friedman is the leader for the physics design.« less

Fusion of PAN and multispectral remote sensing images in shearlet domain by considering regional metrics

NASA Astrophysics Data System (ADS)

Poobalasubramanian, Mangalraj; Agrawal, Anupam

2016-10-01

The presented work proposes fusion of panchromatic and multispectral images in a shearlet domain. The proposed fusion rules rely on the regional considerations which makes the system efficient in terms of spatial enhancement. The luminance hue saturation-based color conversion system is utilized to avoid spectral distortions. The proposed fusion method is tested on Worldview2 and Ikonos datasets, and the proposed method is compared against other methodologies. The proposed fusion method performs well against the other compared methods in terms of subjective and objective evaluations.

Design and implementation of a GPS guidance system for agricultural tractors using augmented reality technology.

PubMed

Santana-Fernández, Javier; Gómez-Gil, Jaime; del-Pozo-San-Cirilo, Laura

2010-01-01

Current commercial tractor guidance systems present to the driver information to perform agricultural tasks in the best way. This information generally includes a treated zones map referenced to the tractor's position. Unlike actual guidance systems where the tractor driver must mentally associate treated zone maps and the plot layout, this paper presents a guidance system that using Augmented Reality (AR) technology, allows the tractor driver to see the real plot though eye monitor glasses with the treated zones in a different color. The paper includes a description of the system hardware and software, a real test done with image captures seen by the tractor driver, and a discussion predicting that the historical evolution of guidance systems could involve the use of AR technology in the agricultural guidance and monitoring systems.

Design and Implementation of a GPS Guidance System for Agricultural Tractors Using Augmented Reality Technology

PubMed Central

Santana-Fernández, Javier; Gómez-Gil, Jaime; del-Pozo-San-Cirilo, Laura

2010-01-01

Current commercial tractor guidance systems present to the driver information to perform agricultural tasks in the best way. This information generally includes a treated zones map referenced to the tractor’s position. Unlike actual guidance systems where the tractor driver must mentally associate treated zone maps and the plot layout, this paper presents a guidance system that using Augmented Reality (AR) technology, allows the tractor driver to see the real plot though eye monitor glasses with the treated zones in a different color. The paper includes a description of the system hardware and software, a real test done with image captures seen by the tractor driver, and a discussion predicting that the historical evolution of guidance systems could involve the use of AR technology in the agricultural guidance and monitoring systems. PMID:22163479

Upgrade of the BATMAN test facility for H- source development

NASA Astrophysics Data System (ADS)

Heinemann, B.; Fröschle, M.; Falter, H.-D.; Fantz, U.; Franzen, P.; Kraus, W.; Nocentini, R.; Riedl, R.; Ruf, B.

2015-04-01

The development of a radio frequency (RF) driven source for negative hydrogen ions for the neutral beam heating devices of fusion experiments has been successfully carried out at IPP since 1996 on the test facility BATMAN. The required ITER parameters have been achieved with the prototype source consisting of a cylindrical driver on the back side of a racetrack like expansion chamber. The extraction system, called "Large Area Grid" (LAG) was derived from a positive ion accelerator from ASDEX Upgrade (AUG) using its aperture size (ø 8 mm) and pattern but replacing the first two electrodes and masking down the extraction area to 70 cm2. BATMAN is a well diagnosed and highly flexible test facility which will be kept operational in parallel to the half size ITER source test facility ELISE for further developments to improve the RF efficiency and the beam properties. It is therefore planned to upgrade BATMAN with a new ITER-like grid system (ILG) representing almost one ITER beamlet group, namely 5 × 14 apertures (ø 14 mm). Additionally to the standard three grid extraction system a repeller electrode upstream of the grounded grid can optionally be installed which is positively charged against it by 2 kV. This is designated to affect the onset of the space charge compensation downstream of the grounded grid and to reduce the backstreaming of positive ions from the drift space backwards into the ion source. For magnetic filter field studies a plasma grid current up to 3 kA will be available as well as permanent magnets embedded into a diagnostic flange or in an external magnet frame. Furthermore different source vessels and source configurations are under discussion for BATMAN, e.g. using the AUG type racetrack RF source as driver instead of the circular one or modifying the expansion chamber for a more flexible position of the external magnet frame.

The NASA-Lewis program on fusion energy for space power and propulsion, 1958-1978

NASA Technical Reports Server (NTRS)

Schulze, Norman R.; Roth, J. Reece

1990-01-01

An historical synopsis is provided of the NASA-Lewis research program on fusion energy for space power and propulsion systems. It was initiated to explore the potential applications of fusion energy to space power and propulsion systems. Some fusion related accomplishments and program areas covered include: basic research on the Electric Field Bumpy Torus (EFBT) magnetoelectric fusion containment concept, including identification of its radial transport mechanism and confinement time scaling; operation of the Pilot Rig mirror machine, the first superconducting magnet facility to be used in plasma physics or fusion research; operation of the Superconducting Bumpy Torus magnet facility, first used to generate a toroidal magnetic field; steady state production of neutrons from DD reactions; studies of the direct conversion of plasma enthalpy to thrust by a direct fusion rocket via propellant addition and magnetic nozzles; power and propulsion system studies, including D(3)He power balance, neutron shielding, and refrigeration requirements; and development of large volume, high field superconducting and cryogenic magnet technology.

Heavy vehicle driver workload assessment. Task 7A, in-cab text message system and cellular phone use by heavy vehicle drivers on road

DOT National Transportation Integrated Search

This report covers the seventh in a series of tasks involving the assessment of driver workload in heavy vehicle operation associated with in-cab devices or systems. This report addresses the application of a workload assessment protocol and measurem...

Drivers` activities and information needs in an automated highway system. Working paper, August 1995-May 1996

DOE Office of Scientific and Technical Information (OSTI.GOV)

Levitan, L.; Bloomfield, J.

1996-10-01

In most visions of the AHS--including that of the National Automated Highway System Consortium--it has been assumed that when a vehicle was under automated control, the driver would be allowed to engage in any of a variety of activities not related to driving (e.g, working, reading, sleeping). The objective of the first study reported here--one of the noncommuter studies--was to determine what drivers do when traveling under automated control, and whether the age of and/gender or the driver and/or the intrastring gap have an influence on those activities. One the objectives of the commuter experiment--of relevance for this report--was tomore » determine whether what drivers do when traveling under automated control changes as a function of experience with the AHS (i.e., across trials). As conceptualization of the AHS proceeds, the details of the interface between the driver and the in-vehicle system will become more important. One part of that interface will be information supplied by the AHS to the driver, perhaps about such things as traffic conditions ahead predicted trip time to the driver`s selected exit, and so on. To maximize the utility of that information, it is important to determine what it is that drivers would like to know when traveling under automated control. The objective of the third study reported here--the second of the five noncommuter experiments--was to provide a first investigation of that issue.« less

Steering disturbance rejection using a physics-based neuromusculoskeletal driver model

NASA Astrophysics Data System (ADS)

Mehrabi, Naser; Sharif Razavian, Reza; McPhee, John

2015-10-01

The aim of this work is to develop a comprehensive yet practical driver model to be used in studying driver-vehicle interactions. Drivers interact with their vehicle and the road through the steering wheel. This interaction forms a closed-loop coupled human-machine system, which influences the driver's steering feel and control performance. A hierarchical approach is proposed here to capture the complexity of the driver's neuromuscular dynamics and the central nervous system in the coordination of the driver's upper extremity activities, especially in the presence of external disturbance. The proposed motor control framework has three layers: the first (or the path planning) plans a desired vehicle trajectory and the required steering angles to perform the desired trajectory; the second (or the musculoskeletal controller) actuates the musculoskeletal arm to rotate the steering wheel accordingly; and the final layer ensures the precision control and disturbance rejection of the motor control units. The physics-based driver model presented here can also provide insights into vehicle control in relaxed and tensed driving conditions, which are simulated by adjusting the driver model parameters such as cognition delay and muscle co-contraction dynamics.

The influence of highly automated driving on the self-perception of drivers in the context of Conduct-by-Wire.

PubMed

Kauer, Michaela; Franz, Benjamin; Maier, Alexander; Bruder, Ralph

2015-01-01

Today, new driving paradigms are being introduced that aim to reduce the number of standalone driver assistance systems by combining these into one overarching system. This is done to reduce the demands on drivers but often leads to a higher degree of automation. Feasibility and driver behaviour are often the subject of studies, but this is contrasted by a lack of research into the influence of highly automated driving on the self-perception of drivers. This article begins to close this gap by investigating the influences of one highly automated driving concept--Conduct-by-Wire--on the self-perception of drivers via a combined driving simulator and interview study. The aim of this work is to identify changes in the role concept of drivers indicated by highly automated driving, to evaluate these changes from the drivers' point of view and to give suggestions of possible improvements to the design of highly automated vehicles.

Image fusion

NASA Technical Reports Server (NTRS)

Pavel, M.

1993-01-01

The topics covered include the following: a system overview of the basic components of a system designed to improve the ability of a pilot to fly through low-visibility conditions such as fog; the role of visual sciences; fusion issues; sensor characterization; sources of information; image processing; and image fusion.

Production of Hev b5 as a fluorescent biotin-binding tripartite fusion protein in insect cells.

PubMed

Nordlund, Henri R; Laitinen, Olli H; Uotila, Sanna T H; Kulmala, Minna; Kalkkinen, Nisse; Kulomaa, Markku S

2005-10-14

The presented green fluorescent protein and streptavidin core-based tripartite fusion system provides a simple and efficient way for the production of proteins fused to it in insect cells. This fusion protein forms a unique tag, which serves as a multipurpose device enabling easy optimization of production, one-step purification via streptavidin-biotin interaction, and visualization of the fusion protein during downstream processing and in applications. In the present study, we demonstrate the successful production, purification, and detection of a natural rubber latex allergen Hev b5 with this system. We also describe the production of another NRL allergen with the system, Hev b1, which formed large aggregates and gave small yields in purification. The aggregates were detected at early steps by microscopical inspection of the infected insect cells producing this protein. Therefore, this fusion system can also be utilized as a fast indicator of the solubility of the expressed fusion proteins and may therefore be extremely useful in high-throughput expression approaches.

Benchmarking image fusion system design parameters

NASA Astrophysics Data System (ADS)

Howell, Christopher L.

2013-06-01

A clear and absolute method for discriminating between image fusion algorithm performances is presented. This method can effectively be used to assist in the design and modeling of image fusion systems. Specifically, it is postulated that quantifying human task performance using image fusion should be benchmarked to whether the fusion algorithm, at a minimum, retained the performance benefit achievable by each independent spectral band being fused. The established benchmark would then clearly represent the threshold that a fusion system should surpass to be considered beneficial to a particular task. A genetic algorithm is employed to characterize the fused system parameters using a Matlab® implementation of NVThermIP as the objective function. By setting the problem up as a mixed-integer constraint optimization problem, one can effectively look backwards through the image acquisition process: optimizing fused system parameters by minimizing the difference between modeled task difficulty measure and the benchmark task difficulty measure. The results of an identification perception experiment are presented, where human observers were asked to identify a standard set of military targets, and used to demonstrate the effectiveness of the benchmarking process.

Effects of rearview cameras and rear parking sensors on police-reported backing crashes.

PubMed

Cicchino, Jessica B

2017-11-17

The objective of this study was to examine the effectiveness of rearview cameras, rear parking sensors, and both systems combined in preventing police-reported backing crashes. Negative binomial regression was used to compare rates of police-reported backing crash involvements per insured vehicle year in 22 U.S. states during 2009-2014 between passenger vehicle models with backing technologies and the same vehicle models where the optional systems were not purchased, controlling for other factors affecting crash risk. Rearview cameras were examined from four automakers, rear parking sensors from 2 automakers, and both systems combined from a single automaker. Rearview cameras reduced backing crash involvement rates by 17%. Reductions were larger for drivers 70 and older (36%) than for drivers younger than 70 (16%); however, estimates for older and younger drivers did not differ significantly from one another. The Buick Lucerne's rear parking sensor system reduced backing crash involvement rates significantly by 34%, but the reduction for Mercedes-Benz vehicles fit with a sensor system was small and not statistically significant. When averaged between the 2 automakers, effects were significantly larger for drivers 70 and older (38% reduction) than for drivers younger than 70 (1% increase); effects were significant for older but not younger drivers. Backing crash involvement rates were 13% lower among Mercedes-Benz vehicles with a rearview camera and parking sensors than among vehicles without, but this finding was not significant. Rearview cameras are effective in preventing police-reported backing crashes. Effects of rear parking sensors are less straightforward; it is unclear whether the Buick Lucerne system's benefits are due to the older age of its drivers, characteristics of the vehicle or system, or a combination. Systems may be especially beneficial to older drivers who might have limitations that make backing challenging. Although effect estimates did not differ significantly between older and younger drivers for both system types, the magnitude of the differences was large and the pattern of results was consistent across 6 of the 7 systems examined. When rear visibility systems become required equipment on new passenger vehicles in 2018, rearview cameras can be expected to prevent 1 in 6 backing crashes reported to police that involve equipped vehicles.

Design and evaluation of steering protection for avoiding collisions during a lane change.

PubMed

Itoh, Makoto; Inagaki, Toshiyuki

2014-01-01

This paper discusses the design of a driver assistance system for avoiding collisions with vehicles in blind spots. The following three types of support systems are compared: (1) a warning system that provides the driver with an auditory alert, (2) a 'soft' protection system that makes the steering wheel stiffer to tell the driver that a lane-change manoeuvre is not recommended and (3) a 'hard' protection system that cancels the driver's input and controls the tyre angle autonomously to prevent lane departure. The results of an experiment showed that the hard protection system was more effective for collision avoidance than either the warning or the soft protection system. The warning and soft protection systems were almost the same in terms of collision avoidance. The results suggest that the human-centred automation principle, which requires the human to have the final authority over the automation, can be violated depending on the context.

Method and system for communicating with a laser power driver

DOEpatents

Telford, Steven

2017-07-18

A system for controlling a plurality of laser diodes includes an optical transmitter coupled to the laser diode driver for each laser diode. An optical signal including bi-phase encoded data is provided to each laser diode driver. The optical signal includes current level and pulse duration information at which each of the diodes is to be driven. Upon receiving a trigger signal, the laser diode drivers operate the laser diodes using the current level and pulse duration information to output a laser beam.

Teen Driver Safety: Additional Research Could Help States Strengthen Graduated Driver Licensing Systems. Report to the Committee on Transportation and Infrastructure and Its Subcommittee on Highways and Transit, House of Representatives. GAO-10-544

ERIC Educational Resources Information Center

Fleming, Susan A.

2010-01-01

Teen drivers ages 16 to 20 have the highest fatality rate of any age group in the United States. As a result, states have increasingly adopted laws to limit teen driving exposure, such as Graduated Driver Licensing (GDL) systems, which consist of three stages: a learner's permit allowing driving only under supervision; intermediate licensure…

Role of input angular momentum and target deformation on the incomplete-fusion dynamics in the 16O+154Sm system at ELab=6.1 MeV/nucleon

NASA Astrophysics Data System (ADS)

Singh, D.; Linda, Sneha B.; Giri, Pankaj K.; Mahato, Amritraj; Tripathi, R.; Kumar, Harish; Ansari, M. Afzal; Sathik, N. P. M.; Ali, Rahbar; Kumar, R.; Muralithar, S.; Singh, R. P.

2018-06-01

Spin distributions of nine evaporation residues 164Yb(x n ) , 163Tm(p x n ) , Er,167168(2 p x n ) , Ho-161163(α p x n ) , 164Dy(α 2 p x n ) , and 160Dy(2 α x n ) produced through complete- and incomplete-fusion reactions have been measured in the system 16O+154Sm at projectile energy =6.1 MeV /nucleon using the in-beam charged-particle (Z =1 ,2 )-γ-ray coincidence technique. The results indicate the occurrence of incomplete fusion involving the breakup of 16O into 4He+12C and/or 8Be+8Be followed by fusion of one of the fragments with target nucleus 154Sm. The pattern of measured spin distributions of the evaporation residues produced through complete and incomplete fusion are found to be entirely different from each other. It has been observed from these present results that the mean input angular momentum for the evaporation residues produced through complete fusion is relatively lower than that of evaporation residues produced through incomplete-fusion reactions. The pattern of feeding intensity of evaporation residues populated through complete- and incomplete-fusion reactions has also been studied. The evaporation residues populated through complete-fusion channels are strongly fed over a broad spin range and widely populated, while evaporation residues populated through incomplete-fusion reactions are found to have narrow range feeding only for high spin states. Comparison of present results with earlier data suggests that the value of mean input angular momentum is relatively higher for a deformed target and more mass asymmetric system than that of a spherical target and less mass asymmetric system by using the same projectile and the same energy. Thus, present results indicate that the incomplete-fusion reactions not only depend on the mass asymmetry of the system, but also depend on the deformation of the target.

NDAS Hardware Translation Layer Development

NASA Technical Reports Server (NTRS)

Nazaretian, Ryan N.; Holladay, Wendy T.

2011-01-01

The NASA Data Acquisition System (NDAS) project is aimed to replace all DAS software for NASA s Rocket Testing Facilities. There must be a software-hardware translation layer so the software can properly talk to the hardware. Since the hardware from each test stand varies, drivers for each stand have to be made. These drivers will act more like plugins for the software. If the software is being used in E3, then the software should point to the E3 driver package. If the software is being used at B2, then the software should point to the B2 driver package. The driver packages should also be filled with hardware drivers that are universal to the DAS system. For example, since A1, A2, and B2 all use the Preston 8300AU signal conditioners, then the driver for those three stands should be the same and updated collectively.

Adapting ISA system warnings to enhance user acceptance.

PubMed

Jiménez, Felipe; Liang, Yingzhen; Aparicio, Francisco

2012-09-01

Inappropriate speed is a major cause of traffic accidents. Different measures have been considered to control traffic speed, and intelligent speed adaptation (ISA) systems are one of the alternatives. These systems know the speed limits and try to improve compliance with them. This paper deals with an informative ISA system that provides the driver with an advance warning before reaching a road section with singular characteristics that require a lower safe speed than the current speed. In spite of the extensive tests performed using ISA systems, few works show how warnings can be adapted to the driver. This paper describes a method to adapt warning parameters (safe speed on curves, zone of influence of a singular stretch, deceleration process and reaction time) to normal driving behavior. The method is based on a set of tests with and without the ISA system. This adjustment, as well as the analysis of driver acceptance before and after the adaptation and changes in driver behavior (changes in speed and path) resulting from the tested ISA regarding a driver's normal driving style, is shown in this paper. The main conclusion is that acceptance by drivers increased significantly after redefining the warning parameters, but the effect of speed homogenization was not reduced. Copyright © 2010 Elsevier Ltd. All rights reserved.

Design of a Fatigue Detection System for High-Speed Trains Based on Driver Vigilance Using a Wireless Wearable EEG

PubMed Central

Zhang, Xiaoliang; Li, Jiali; Liu, Yugang; Zhang, Zutao; Wang, Zhuojun; Luo, Dianyuan; Zhou, Xiang; Zhu, Miankuan; Salman, Waleed; Hu, Guangdi; Wang, Chunbai

2017-01-01

The vigilance of the driver is important for railway safety, despite not being included in the safety management system (SMS) for high-speed train safety. In this paper, a novel fatigue detection system for high-speed train safety based on monitoring train driver vigilance using a wireless wearable electroencephalograph (EEG) is presented. This system is designed to detect whether the driver is drowsiness. The proposed system consists of three main parts: (1) a wireless wearable EEG collection; (2) train driver vigilance detection; and (3) early warning device for train driver. In the first part, an 8-channel wireless wearable brain-computer interface (BCI) device acquires the locomotive driver’s brain EEG signal comfortably under high-speed train-driving conditions. The recorded data are transmitted to a personal computer (PC) via Bluetooth. In the second step, a support vector machine (SVM) classification algorithm is implemented to determine the vigilance level using the Fast Fourier transform (FFT) to extract the EEG power spectrum density (PSD). In addition, an early warning device begins to work if fatigue is detected. The simulation and test results demonstrate the feasibility of the proposed fatigue detection system for high-speed train safety. PMID:28257073

Sequential CD4-Coreceptor Interactions in Human Immunodeficiency Virus Type 1 Env Function: Soluble CD4 Activates Env for Coreceptor-Dependent Fusion and Reveals Blocking Activities of Antibodies against Cryptic Conserved Epitopes on gp120

PubMed Central

Salzwedel, Karl; Smith, Erica D.; Dey, Barna; Berger, Edward A.

2000-01-01

We devised an experimental system to examine sequential events by which the human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein (Env) interacts with CD4 and coreceptor to induce membrane fusion. Recombinant soluble CD4 (sCD4) activated fusion between effector cells expressing Env and target cells expressing coreceptor (CCR5 or CXCR4) but lacking CD4. sCD4-activated fusion was dose dependent, occurred comparably with two- and four-domain proteins, and demonstrated Env-coreceptor specificities parallel to those reported in conventional fusion and infectivity systems. Fusion activation occurred upon sCD4 preincubation and washing of the Env-expressing effector cells but not the coreceptor-bearing target cells, thereby demonstrating that sCD4 exerts its effects by acting on Env. These findings provide direct functional evidence for a sequential two-step model of Env-receptor interactions, whereby gp120 binds first to CD4 and becomes activated for subsequent functional interaction with coreceptor, leading to membrane fusion. We used the sCD4-activated system to explore neutralization by the anti-gp120 human monoclonal antibodies 17b and 48d. These antibodies reportedly bind conserved CD4-induced epitopes involved in coreceptor interactions but neutralize HIV-1 infection only weakly. We found that 17b and 48d had minimal effects in the standard cell fusion system using target cells expressing both CD4 and coreceptor but potently blocked sCD4-activated fusion with target cells expressing coreceptor alone. Both antibodies strongly inhibited sCD4-activated fusion by Envs from genetically diverse HIV-1 isolates. Thus, the sCD4-activated system reveals conserved Env-blocking epitopes that are masked in native Env and hence not readily detected by conventional systems. PMID:10590121

Future Directions for Fusion Propulsion Research at NASA

NASA Technical Reports Server (NTRS)

Adams, Robert B.; Cassibry, Jason T.

2005-01-01

Fusion propulsion is inevitable if the human race remains dedicated to exploration of the solar system. There are fundamental reasons why fusion surpasses more traditional approaches to routine crewed missions to Mars, crewed missions to the outer planets, and deep space high speed robotic missions, assuming that reduced trip times, increased payloads, and higher available power are desired. A recent series of informal discussions were held among members from government, academia, and industry concerning fusion propulsion. We compiled a sufficient set of arguments for utilizing fusion in space. .If the U.S. is to lead the effort and produce a working system in a reasonable amount of time, NASA must take the initiative, relying on, but not waiting for, DOE guidance. Arguments for fusion propulsion are presented, along with fusion enabled mission examples, fusion technology trade space, and a proposed outline for future efforts.

CAMAC driver for the RSX-11M V3 operating system

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tippie, J. W.; Cannon, P. H.

1977-01-01

A driver for Kinetic Systems 3911A dedicated crate controller and 3992 serial highway driver for RSX-11M is described. The implementation includes a modified UCB structure. With this structure, multiple active I/O requests are supported to a single controller. The completion of an I/O request may be tied to external events via a WAIT-FOR-LAM command. Features of the driver include the ability to pass a list of FNA's in a single QIO call, serial highway overhead transparent at the QIO level, and special control commands to the driver passed in the FNA list. 1 figure.

What the drivers do and do not tell you: using verbal protocol analysis to investigate driver behaviour in emergency situations.

PubMed

Banks, Victoria A; Stanton, Neville A; Harvey, Catherine

2014-01-01

Although task analysis of pedestrian detection can provide us with useful insights into how a driver may behave in emergency situations, the cognitive elements of driver decision-making are less well understood. To assist in the design of future Advanced Driver Assistance Systems, such as Autonomous Emergency Brake systems, it is essential that the cognitive elements of the driving task are better understood. This paper uses verbal protocol analysis in an exploratory fashion to uncover the thought processes underlying behavioural outcomes represented by hard data collected using the Southampton University Driving Simulator.

Use patterns among early adopters of adaptive cruise control.

PubMed

Xiong, Huimin; Boyle, Linda Ng; Moeckli, Jane; Dow, Benjamin R; Brown, Timothy L

2012-10-01

The objective of this study was to investigate use patterns among early adopters of adaptive cruise control (ACC). Extended use ofACC may influence a driver's behavior in the long-term, which can have unintended safety consequences. The authors examined the use of a motion-based simulator by 24 participants (15 males and 9 females). Cluster analysis was performed on drivers' use of ACC and was based on their gap settings, speed settings, number of warnings issued, and ACC disengaged. The data were then examined on the basis of driving performance measures and drivers' subjective responses to trust in ACC, understanding of system operations, and driving styles. Driving performance measures included minimum time headway, adjusted minimum time to collision, and drivers' reaction time to critical events. Three groups of drivers were observed on the basis of risky behavior, moderately risky behavior, and conservative behavior. Drivers in the conservative group stayed farther behind the lead vehicle than did drivers in the other two groups. Risky drivers responded later to critical events and had more ACC warnings issued. Safety consequences with ACC may be more prevalent in some driver groups than others. The findings suggest that these safety implications are related to trust in automation, driving styles, understanding of system operations, and personalities. Potential applications of this research include enhanced design for next-generation ACC systems and countermeasures to improve safe driving with ACC.

PILOT RESULTS ON FORWARD COLLISION WARNING SYSTEM EFFECTIVENESS IN OLDER DRIVERS

PubMed Central

Lester, Benjamin D.; Sager, Lauren N.; Dawson, Jeffrey; Hacker, Sarah D.; Aksan, Nazan; Rizzo, Matthew; Kitazaki, Satoshi

2016-01-01

Summary Advanced Driver Assistance Systems (ADAS) have largely been developed with a “one-size-fits-all” approach. This approach neglects the large inter-individual variability in perceptual and cognitive abilities that affect aging ADAS users. We investigated the effectiveness of a forward collision warning (FCW) with fixed response parameters in young and older drivers with differing levels of cognitive functioning. Drivers responded to a pedestrian stepping into the driver’s path on a simulated urban road. Behavioral metrics included response times (RT) for pedal controls and two indices of risk penetration (e.g., maximum deceleration and minimum time-to-collision (TTC)). Older drivers showed significantly slower responses at several time points compared to younger drivers. The FCW facilitated response times (RTs) for older and younger drivers. However, older drivers still showed smaller safety gains compared to younger drivers at accelerator pedal release and initial brake application when the FCW was active. No significant differences in risk metrics were observed within the condition studied. The results demonstrate older drivers likely differ from younger drivers using a FCW with a fixed parameter set. Finally, we briefly discuss how future research should examine predictive relationships between domains of cognitive functioning and ADAS responses to develop parameter sets to fit the individual. PMID:27135061

Fusion of imaging and nonimaging data for surveillance aircraft

NASA Astrophysics Data System (ADS)

Shahbazian, Elisa; Gagnon, Langis; Duquet, Jean Remi; Macieszczak, Maciej; Valin, Pierre

1997-06-01

This paper describes a phased incremental integration approach for application of image analysis and data fusion technologies to provide automated intelligent target tracking and identification for airborne surveillance on board an Aurora Maritime Patrol Aircraft. The sensor suite of the Aurora consists of a radar, an identification friend or foe (IFF) system, an electronic support measures (ESM) system, a spotlight synthetic aperture radar (SSAR), a forward looking infra-red (FLIR) sensor and a link-11 tactical datalink system. Lockheed Martin Canada (LMCan) is developing a testbed, which will be used to analyze and evaluate approaches for combining the data provided by the existing sensors, which were initially not designed to feed a fusion system. Three concurrent research proof-of-concept activities provide techniques, algorithms and methodology into three sequential phases of integration of this testbed. These activities are: (1) analysis of the fusion architecture (track/contact/hybrid) most appropriate for the type of data available, (2) extraction and fusion of simple features from the imaging data into the fusion system performing automatic target identification, and (3) development of a unique software architecture which will permit integration and independent evolution, enhancement and optimization of various decision aid capabilities, such as multi-sensor data fusion (MSDF), situation and threat assessment (STA) and resource management (RM).

An Evaluation of Graduated Driver Licensing Effects on Fatal Crash Involvements of Young Drivers in the United States

PubMed Central

Fell, James C.; Jones, Kristina; Romano, Eduardo; Voas, Robert

2013-01-01

Objective Graduated driver licensing (GDL) systems are designed to reduce the high crash risk of young novice drivers. Almost all states in the United States have some form of a three-phased GDL system with various restrictions in the intermediate phase. Studies of the effects of GDL in various states show significant reductions in fatal crash involvements of 16- and 17-year-old drivers; however, only a few national studies of GDL effects have been published. The objective of this national panel study was to evaluate the effect of GDL laws on the fatal crash involvements of novice drivers while controlling for possible confounding factors not accounted for in prior studies. Methods The Fatality Analysis Reporting System (FARS) was used to examine 16- and 17-year-old driver involvement in fatal crashes (where GDL laws are applied) relative to two young driver age groups (19-20, 21-25) where GDL would not be expected to have an effect. Dates when various GDL laws were adopted in the states between 1990 and 2007 were coded from a variety of sources. Covariates in the longitudinal panel regression analyses conducted included four laws that could have an effect on 16- and 17-year-old drivers: primary enforcement seat belt laws, zero-tolerance (ZT) alcohol laws for drivers younger than age 21, lowering the blood alcohol concentration limit for driving to .08, and so-called “use and lose” laws where drivers aged 20 and younger lose their licenses for underage drinking violations. Results The adoption of a GDL law of average strength was associated with a significant decrease in fatal crash involvements of 16- and 17-year-old drivers relative to fatal crash involvements of one of the two comparison groups. GDL laws rated as “good” showed stronger relationships to fatal crash reductions, and laws rated as “less than good” showed no reductions in crash involvements relative to the older driver comparison groups. Conclusions States that adopt a basic GDL law can expect a decrease of 8 to 14% in the proportion of 16- and 17-year-old drivers involved in fatal crashes (relative to 21- to 25-year-old drivers), depending upon their other existing laws that affect novice drivers, such as those used in these analyses. This finding is consistent with recent national studies that used different outcome measures and covariates. The results of this study provide additional support for states to adopt, maintain, and upgrade GDL systems to reduce youthful traffic crash fatalities. PMID:21972851

Systematic investigations of deep sub-barrier fusion reactions using an adiabatic approach

NASA Astrophysics Data System (ADS)

Ichikawa, Takatoshi

2015-12-01

Background: At extremely low incident energies, unexpected decreases in fusion cross sections, compared to the standard coupled-channels (CC) calculations, have been observed in a wide range of fusion reactions. These significant reductions of the fusion cross sections are often referred to as the fusion hindrance. However, the physical origin of the fusion hindrance is still unclear. Purpose: To describe the fusion hindrance based on an adiabatic approach, I propose a novel extension of the standard CC model by introducing a damping factor that describes a smooth transition from sudden to adiabatic processes, that is, the transition from the separated two-body to the united dinuclear system. I demonstrate the performance of this model by systematically investigating various deep sub-barrier fusion reactions. Method: I extend the standard CC model by introducing a damping factor into the coupling matrix elements in the standard CC model. This avoids double counting of the CC effects, when two colliding nuclei overlap one another. I adopt the Yukawa-plus-exponential (YPE) model as a basic heavy ion-ion potential, which is advantageous for a unified description of the one- and two-body potentials. For the purpose of these systematic investigations, I approximate the one-body potential with a third-order polynomial function based on the YPE model. Results: Calculated fusion cross sections for the medium-heavy mass systems of 64Ni+64Ni , 58Ni+58Ni , and 58Ni+54Fe , the medium-light mass systems of 40Ca+40Ca , 48Ca+48Ca , and 24Mg+30Si , and the mass-asymmetric systems of 48Ca+96Zr and 16O+208Pb are consistent with the experimental data. The astrophysical S factor and logarithmic derivative representations of these are also in good agreement with the experimental data. The values obtained for the individual radius and diffuseness parameters in the damping factor, which reproduce the fusion cross sections well, are nearly equal to the average value for all the systems. Conclusions: Since the results calculated with the damping factor are in excellent agreement with the experimental data in all systems, I conclude that a coordinate-dependent coupling strength is responsible for the fusion hindrance. In all systems, the potential energies at the touching point VTouch strongly correlate with the incident threshold energies for which the fusion hindrance starts to emerge, except for the medium-light mass systems.

Sensor fusion V; Proceedings of the Meeting, Boston, MA, Nov. 15-17, 1992

NASA Technical Reports Server (NTRS)

Schenker, Paul S. (Editor)

1992-01-01

Topics addressed include 3D object perception, human-machine interface in multisensor systems, sensor fusion architecture, fusion of multiple and distributed sensors, interface and decision models for sensor fusion, computational networks, simple sensing for complex action, multisensor-based control, and metrology and calibration of multisensor systems. Particular attention is given to controlling 3D objects by sketching 2D views, the graphical simulation and animation environment for flexible structure robots, designing robotic systems from sensorimotor modules, cylindrical object reconstruction from a sequence of images, an accurate estimation of surface properties by integrating information using Bayesian networks, an adaptive fusion model for a distributed detection system, multiple concurrent object descriptions in support of autonomous navigation, robot control with multiple sensors and heuristic knowledge, and optical array detectors for image sensors calibration. (No individual items are abstracted in this volume)

Adjacent level effects of bi level disc replacement, bi level fusion and disc replacement plus fusion in cervical spine--a finite element based study.

PubMed

Faizan, Ahmad; Goel, Vijay K; Biyani, Ashok; Garfin, Steven R; Bono, Christopher M

2012-03-01

Studies delineating the adjacent level effect of single level disc replacement systems have been reported in literature. The aim of this study was to compare the adjacent level biomechanics of bi-level disc replacement, bi-level fusion and a construct having adjoining level disc replacement and fusion system. In total, biomechanics of four models- intact, bi level disc replacement, bi level fusion and fusion plus disc replacement at adjoining levels- was studied to gain insight into the effects of various instrumentation systems on cranial and caudal adjacent levels using finite element analysis (73.6N+varying moment). The bi-level fusion models are more than twice as stiff as compared to the intact model during flexion-extension, lateral bending and axial rotation. Bi-level disc replacement model required moments lower than intact model (1.5Nm). Fusion plus disc replacement model required moment 10-25% more than intact model, except in extension. Adjacent level motions, facet loads and endplate stresses increased substantially in the bi-level fusion model. On the other hand, adjacent level motions, facet loads and endplate stresses were similar to intact for the bi-level disc replacement model. For the fusion plus disc replacement model, adjacent level motions, facet loads and endplate stresses were closer to intact model rather than the bi-level fusion model, except in extension. Based on our finite element analysis, fusion plus disc replacement procedure has less severe biomechanical effects on adjacent levels when compared to bi-level fusion procedure. Bi-level disc replacement procedure did not have any adverse mechanical effects on adjacent levels. Copyright © 2011 Elsevier Ltd. All rights reserved.

Conceptual design studies of the Electron Cyclotron launcher for DEMO reactor

NASA Astrophysics Data System (ADS)

Moro, Alessandro; Bruschi, Alex; Franke, Thomas; Garavaglia, Saul; Granucci, Gustavo; Grossetti, Giovanni; Hizanidis, Kyriakos; Tigelis, Ioannis; Tran, Minh-Quang; Tsironis, Christos

2017-10-01

A demonstration fusion power plant (DEMO) producing electricity for the grid at the level of a few hundred megawatts is included in the European Roadmap [1]. The engineering design and R&D for the electron cyclotron (EC), ion cyclotron and neutral beam systems for the DEMO reactor is being performed by Work Package Heating and Current Drive (WPHCD) in the framework of EUROfusion Consortium activities. The EC target power to the plasma is about 50 MW, in which the required power for NTM control and burn control is included. EC launcher conceptual design studies are here presented, showing how the main design drivers of the system have been taken into account (physics requirements, reactor relevant operations, issues related to its integration as in-vessel components). Different options for the antenna are studied in a parameters space including a selection of frequencies, injection angles and launch points to get the best performances for the antenna configuration, using beam tracing calculations to evaluate plasma accessibility and deposited power. This conceptual design studies comes up with the identification of possible limits, constraints and critical issues, essential in the selection process of launcher setup solution.

Engineering design of the PLX- α coaxial gun

NASA Astrophysics Data System (ADS)

Cruz, E.; Brockington, S.; Case, A.; Luna, M.; Witherspoon, F. D.; Thio, Y. C. Francis; PLX-α Team

2017-10-01

We describe the engineering and technical improvements, as well as provide a detailed overview of the design choices, of the latest PLX- α coaxial gun designed for the 60-gun scaling study of spherically imploding plasma liners as a standoff driver for plasma-jet-driven magneto-inertial fusion. Each coaxial gun incorporates a fast, dense gas injection and triggering system, a compact low-weight pfn with integral sparkgap switching, and a contoured gap designed to suppress the blow-by instability. The evolution of the latest Alpha gun is presented with emphasis on its upgraded performance. Changes include a faster more robust gas valve, better-quality ceramic insulator material and enhancements to overall design layout. These changes result in a gun with increased repeatability, reduced potential failure modes, improved fault tolerance and better than expected efficiency. A custom 600- μF, 5-kV pfn and a set of six inline sparkgap switches operated in parallel are mounted directly to the back of the gun, and are designed to reduce inductance, cost, and complexity, maximize efficiency and system reliability, and ensure symmetric current flow. This work supported by the ARPA-E ALPHA Program under contract DE-AR0000566 and Strong Atomics, LLC.

Ontological Issues in Higher Levels of Information Fusion: User Refinement of the Fusion Process

DTIC Science & Technology

2003-01-01

fusion question, the thing that is separates the Greek We explore the higher-level purpose offusion systems by philosophical questions and modem day...the The Greeks focused on both data fusion and the Fusion02 conference there are common fusion questions philosophical questions of an ontology - the...data World of Visible Things Belief (pistis) fusion - user refinement. The rest of the paper is as Appearances follows: Section 2 details the Greek

A protein disulfide isomerase gene fusion expression system that increases the extracellular productivity of Bacillus brevis.

PubMed

Kajino, T; Ohto, C; Muramatsu, M; Obata, S; Udaka, S; Yamada, Y; Takahashi, H

2000-02-01

We have developed a versatile Bacillus brevis expression and secretion system based on the use of fungal protein disulfide isomerase (PDI) as a gene fusion partner. Fusion with PDI increased the extracellular production of heterologous proteins (light chain of immunoglobulin G, 8-fold; geranylgeranyl pyrophosphate synthase, 12-fold). Linkage to PDI prevented the aggregation of the secreted proteins, resulting in high-level accumulation of fusion proteins in soluble and biologically active forms. We also show that the disulfide isomerase activity of PDI in a fusion protein is responsible for the suppression of the aggregation of the protein with intradisulfide, whereas aggregation of the protein without intradisulfide was prevented even when the protein was fused to a mutant PDI whose two active sites were disrupted, suggesting that another PDI function, such as chaperone-like activity, synergistically prevented the aggregation of heterologous proteins in the PDI fusion expression system.

A Protein Disulfide Isomerase Gene Fusion Expression System That Increases the Extracellular Productivity of Bacillus brevis

PubMed Central

Kajino, Tsutomu; Ohto, Chikara; Muramatsu, Masayoshi; Obata, Shusei; Udaka, Shigezo; Yamada, Yukio; Takahashi, Haruo

2000-01-01

We have developed a versatile Bacillus brevis expression and secretion system based on the use of fungal protein disulfide isomerase (PDI) as a gene fusion partner. Fusion with PDI increased the extracellular production of heterologous proteins (light chain of immunoglobulin G, 8-fold; geranylgeranyl pyrophosphate synthase, 12-fold). Linkage to PDI prevented the aggregation of the secreted proteins, resulting in high-level accumulation of fusion proteins in soluble and biologically active forms. We also show that the disulfide isomerase activity of PDI in a fusion protein is responsible for the suppression of the aggregation of the protein with intradisulfide, whereas aggregation of the protein without intradisulfide was prevented even when the protein was fused to a mutant PDI whose two active sites were disrupted, suggesting that another PDI function, such as chaperone-like activity, synergistically prevented the aggregation of heterologous proteins in the PDI fusion expression system. PMID:10653729

Impact of Automation on Drivers' Performance in Agricultural Semi-Autonomous Vehicles.

PubMed

Bashiri, B; Mann, D D

2015-04-01

Drivers' inadequate mental workload has been reported as one of the negative effects of driving assistant systems and in-vehicle automation. The increasing trend of automation in agricultural vehicles raises some concerns about drivers' mental workload in such vehicles. Thus, a human factors perspective is needed to identify the consequences of such automated systems. In this simulator study, the effects of vehicle steering task automation (VSTA) and implement control and monitoring task automation (ICMTA) were investigated using a tractor-air seeder system as a case study. Two performance parameters (reaction time and accuracy of actions) were measured to assess drivers' perceived mental workload. Experiments were conducted using the tractor driving simulator (TDS) located in the Agricultural Ergonomics Laboratory at the University of Manitoba. Study participants were university students with tractor driving experience. According to the results, reaction time and number of errors made by drivers both decreased as the automation level increased. Correlations were found among performance parameters and subjective mental workload reported by the drivers.

Modelling the influence of sensory dynamics on linear and nonlinear driver steering control

NASA Astrophysics Data System (ADS)

Nash, C. J.; Cole, D. J.

2018-05-01

A recent review of the literature has indicated that sensory dynamics play an important role in the driver-vehicle steering task, motivating the design of a new driver model incorporating human sensory systems. This paper presents a full derivation of the linear driver model developed in previous work, and extends the model to control a vehicle with nonlinear tyres. Various nonlinear controllers and state estimators are compared with different approximations of the true system dynamics. The model simulation time is found to increase significantly with the complexity of the controller and state estimator. In general the more complex controllers perform best, although with certain vehicle and tyre models linearised controllers perform as well as a full nonlinear optimisation. Various extended Kalman filters give similar results, although the driver's sensory dynamics reduce control performance compared with full state feedback. The new model could be used to design vehicle systems which interact more naturally and safely with a human driver.

Advances in computational approaches for prioritizing driver mutations and significantly mutated genes in cancer genomes.

PubMed

Cheng, Feixiong; Zhao, Junfei; Zhao, Zhongming

2016-07-01

Cancer is often driven by the accumulation of genetic alterations, including single nucleotide variants, small insertions or deletions, gene fusions, copy-number variations, and large chromosomal rearrangements. Recent advances in next-generation sequencing technologies have helped investigators generate massive amounts of cancer genomic data and catalog somatic mutations in both common and rare cancer types. So far, the somatic mutation landscapes and signatures of >10 major cancer types have been reported; however, pinpointing driver mutations and cancer genes from millions of available cancer somatic mutations remains a monumental challenge. To tackle this important task, many methods and computational tools have been developed during the past several years and, thus, a review of its advances is urgently needed. Here, we first summarize the main features of these methods and tools for whole-exome, whole-genome and whole-transcriptome sequencing data. Then, we discuss major challenges like tumor intra-heterogeneity, tumor sample saturation and functionality of synonymous mutations in cancer, all of which may result in false-positive discoveries. Finally, we highlight new directions in studying regulatory roles of noncoding somatic mutations and quantitatively measuring circulating tumor DNA in cancer. This review may help investigators find an appropriate tool for detecting potential driver or actionable mutations in rapidly emerging precision cancer medicine. © The Author 2015. Published by Oxford University Press. For Permissions, please email: journals.permissions@oup.com.

A flexible data fusion architecture for persistent surveillance using ultra-low-power wireless sensor networks

NASA Astrophysics Data System (ADS)

Hanson, Jeffrey A.; McLaughlin, Keith L.; Sereno, Thomas J.

2011-06-01

We have developed a flexible, target-driven, multi-modal, physics-based fusion architecture that efficiently searches sensor detections for targets and rejects clutter while controlling the combinatoric problems that commonly arise in datadriven fusion systems. The informational constraints imposed by long lifetime requirements make systems vulnerable to false alarms. We demonstrate that our data fusion system significantly reduces false alarms while maintaining high sensitivity to threats. In addition, mission goals can vary substantially in terms of targets-of-interest, required characterization, acceptable latency, and false alarm rates. Our fusion architecture provides the flexibility to match these trade-offs with mission requirements unlike many conventional systems that require significant modifications for each new mission. We illustrate our data fusion performance with case studies that span many of the potential mission scenarios including border surveillance, base security, and infrastructure protection. In these studies, we deployed multi-modal sensor nodes - including geophones, magnetometers, accelerometers and PIR sensors - with low-power processing algorithms and low-bandwidth wireless mesh networking to create networks capable of multi-year operation. The results show our data fusion architecture maintains high sensitivities while suppressing most false alarms for a variety of environments and targets.

To delegate or not to delegate: A review of control frameworks for autonomous cars.

PubMed

Richards, Dale; Stedmon, Alex

2016-03-01

There have been significant advances in technology and automated systems that will eventually see the use of autonomous cars as commonplace on our roads. Various systems are already available that provide the driver with different levels of decision support. This paper highlights the key human factors issues associated with the interaction between the user and an autonomous system, including assistive decision support and the delegation of authority to the automobile. The level of support offered to the driver can range from traditional automated assistance, to system generated guidance that offers advice for the driver to act upon, and even more direct action that is initiated by the system itself without driver intervention. In many of these instances the role of the driver is slowly moving towards a supervisory role within a complex system rather than one of direct control of the vehicle. Different paradigms of interaction are considered and focus is placed on the partnership that takes place between the driver and the vehicle. Drawing on the wealth of knowledge that exists within the aviation domain and research literature that examines technology partnerships within the cockpit, this paper considers important factors that will assist the automotive community to understand the underlying issues of the human and their interaction within complex systems. Copyright © 2015 Elsevier Ltd and The Ergonomics Society. All rights reserved.

Influence of the configuration of the magnetic filter field on the discharge structure in the RF driven negative ion source prototype for fusion

NASA Astrophysics Data System (ADS)

Lishev, S.; Schiesko, L.; Wünderlich, D.; Fantz, U.

2017-08-01

The study provides results for the influence of the filter field topology on the plasma parameters in the RF prototype negative ion source for ITER NBI. A previously developed 2D fluid plasma model of the prototype source was extended towards accounting for the particles and energy losses along the magnetic field lines and the presence of a magnetic field in the driver which is the case at the BATMAN and ELISE test-beds. The effect of the magnetic field in the driver is shown for the magnetic field configuration of the prototype source (i.e. a magnetic field produced by an external magnet frame) by comparison of plasma parameters without and with the magnetic field in the driver and for different axial positions of the filter. Since the ELISE-like magnetic field (i.e. a magnetic field produced by a current flowing through the plasma grid) is a new feature planned to be installed at the BATMAN test-bed, its effect on the discharge structure was studied for different strengths of the magnetic field. The obtained results show for both configurations of the magnetic filter the same main features in the patterns of the plasma parameters in the expansion chamber: a strong axial drop of the electron temperature and the formation of a groove accompanied with accumulation of electrons in front of the plasma grid. The presence of a magnetic field in the driver has a local impact on the plasma parameters: the formation of a second groove of the electron temperature in the case of BATMAN (due to the reversed direction of the filter field in the driver) and a strong asymmetry of the electron density. Accounting for the additional losses in the third dimension suppresses the drifts across the magnetic field and, thus, the variations of the electron density in the expansion chamber are less pronounced.

Perception and biodynamics in unalerted precrash response.

PubMed

McGehee, Daniel V; Carsten, Oliver M J

2010-01-01

This research seeks to better understand unalerted driver response just prior to a serious vehicle crash. Few studies have been able to view a crash from the inside-with a camera focused on the driver and occupants. Four studies are examined: 1) a high-fidelity simulator study with an unalerted intersection incursion crash among 107 drivers; 2) four crashes from the Virginia Tech Transportation Institute (VTTI) 100 car study; 3) 58 crashes from vehicles equipped with an event triggered video recorder; and 4) a custom-designed high-fidelity simulator experiment that examined unalerted driver response to a head-on crash with a heavy truck. Analyses concentrate on decomposing driver perception, action, facial and postural changes with a focus on describing the neurophysiologic mechanisms designed to respond to danger. Results indicate that drivers involved in severe crashes generally have preview that an impact is about to occur. They respond first with vehicle control inputs (accelerator pedal release) along with facial state changes and withdrawal of the head back towards the head restraint. These responses frequently occur almost simultaneously, providing safety system designers with a number of reliable driver performance measures to monitor. Understanding such mechanisms may assist future advanced driver assistance systems (ADAS), advanced restraints, model development of advanced anthropomorphic test dummies (ATDs), injury prediction and the integration of active and passive safety systems.

Minimum Required Attention: A Human-Centered Approach to Driver Inattention.

PubMed

Kircher, Katja; Ahlstrom, Christer

2017-05-01

To propose a driver attention theory based on the notion of driving as a satisficing and partially self-paced task and, within this framework, present a definition for driver inattention. Many definitions of driver inattention and distraction have been proposed, but they are difficult to operationalize, and they are either unreasonably strict and inflexible or suffer from hindsight bias. Existing definitions of driver distraction are reviewed and their shortcomings identified. We then present the minimum required attention (MiRA) theory to overcome these shortcomings. Suggestions on how to operationalize MiRA are also presented. MiRA describes which role the attention of the driver plays in the shared "situation awareness of the traffic system." A driver is considered attentive when sampling sufficient information to meet the demands of the system, namely, that he or she fulfills the preconditions to be able to form and maintain a good enough mental representation of the situation. A driver should only be considered inattentive when information sampling is not sufficient, regardless of whether the driver is concurrently executing an additional task or not. The MiRA theory builds on well-established driver attention theories. It goes beyond available driver distraction definitions by first defining what a driver needs to be attentive to, being free from hindsight bias, and allowing the driver to adapt to the current demands of the traffic situation through satisficing and self-pacing. MiRA has the potential to provide the stepping stone for unbiased and operationalizable inattention detection and classification.

Context Representation and Fusion: Advancements and Opportunities

PubMed Central

Khattak, Asad Masood; Akbar, Noman; Aazam, Mohammad; Ali, Taqdir; Khan, Adil Mehmood; Jeon, Seokhee; Hwang, Myunggwon; Lee, Sungyoung

2014-01-01

The acceptance and usability of context-aware systems have given them the edge of wide use in various domains and has also attracted the attention of researchers in the area of context-aware computing. Making user context information available to such systems is the center of attention. However, there is very little emphasis given to the process of context representation and context fusion which are integral parts of context-aware systems. Context representation and fusion facilitate in recognizing the dependency/relationship of one data source on another to extract a better understanding of user context. The problem is more critical when data is emerging from heterogeneous sources of diverse nature like sensors, user profiles, and social interactions and also at different timestamps. Both the processes of context representation and fusion are followed in one way or another; however, they are not discussed explicitly for the realization of context-aware systems. In other words most of the context-aware systems underestimate the importance context representation and fusion. This research has explicitly focused on the importance of both the processes of context representation and fusion and has streamlined their existence in the overall architecture of context-aware systems’ design and development. Various applications of context representation and fusion in context-aware systems are also highlighted in this research. A detailed review on both the processes is provided in this research with their applications. Future research directions (challenges) are also highlighted which needs proper attention for the purpose of achieving the goal of realizing context-aware systems. PMID:24887042

A meta-analysis of in-vehicle and nomadic voice-recognition system interaction and driving performance.

PubMed

Simmons, Sarah M; Caird, Jeff K; Steel, Piers

2017-09-01

Driver distraction is a growing and pervasive issue that requires multiple solutions. Voice-recognition (V-R) systems may decrease the visual-manual (V-M) demands of a wide range of in-vehicle system and smartphone interactions. However, the degree that V-R systems integrated into vehicles or available in mobile phone applications affect driver distraction is incompletely understood. A comprehensive meta-analysis of experimental studies was conducted to address this knowledge gap. To meet study inclusion criteria, drivers had to interact with a V-R system while driving and doing everyday V-R tasks such as dialing, initiating a call, texting, emailing, destination entry or music selection. Coded dependent variables included detection, reaction time, lateral position, speed and headway. Comparisons of V-R systems with baseline driving and/or a V-M condition were also coded. Of 817 identified citations, 43 studies involving 2000 drivers and 183 effect sizes (r) were analyzed in the meta-analysis. Compared to baseline, driving while interacting with a V-R system is associated with increases in reaction time and lane positioning, and decreases in detection. When V-M systems were compared to V-R systems, drivers had slightly better performance with the latter system on reaction time, lane positioning and headway. Although V-R systems have some driving performance advantages over V-M systems, they have a distraction cost relative to driving without any system at all. The pattern of results indicates that V-R systems impose moderate distraction costs on driving. In addition, drivers minimally engage in compensatory performance adjustments such as reducing speed and increasing headway while using V-R systems. Implications of the results for theory, design guidelines and future research are discussed. Copyright © 2017 Elsevier Ltd. All rights reserved.

Tritium Breeding Blanket for a Commercial Fusion Power Plant - A System Engineering Assessment

DOE Office of Scientific and Technical Information (OSTI.GOV)

Meier, Wayne R.

The goal of developing a new source of electric power based on fusion has been pursued for decades. If successful, future fusion power plants will help meet growing world-wide demand for electric power. A key feature and selling point for fusion is that its fuel supply is widely distributed globally and virtually inexhaustible. Current world-wide research on fusion energy is focused on the deuterium-tritium (DT for short) fusion reaction since it will be the easiest to achieve in terms of the conditions (e.g., temperature, density and confinement time of the DT fuel) required to produce net energy. Over the pastmore » decades countless studies have examined various concepts for TBBs for both magnetic fusion energy (MFE) and inertial fusion energy (IFE). At this time, the key organizations involved are government sponsored research organizations world-wide. The near-term focus of the MFE community is on the development of TBB mock-ups to be tested on the ITER tokamak currently under construction in Caderache France. TBB concepts for IFE tend to be different from MFE primarily due to significantly different operating conditions and constraints. This report focuses on longer-term commercial power plants where the key stakeholders include: electric utilities, plant owner and operator, manufacturer, regulators, utility customers, and in-plant subsystems including the heat transfer and conversion systems, fuel processing system, plant safety systems, and the monitoring control systems.« less

Multisensor Parallel Largest Ellipsoid Distributed Data Fusion with Unknown Cross-Covariances

PubMed Central

Liu, Baoyu; Zhan, Xingqun; Zhu, Zheng H.

2017-01-01

As the largest ellipsoid (LE) data fusion algorithm can only be applied to two-sensor system, in this contribution, parallel fusion structure is proposed to introduce the LE algorithm into a multisensor system with unknown cross-covariances, and three parallel fusion structures based on different estimate pairing methods are presented and analyzed. In order to assess the influence of fusion structure on fusion performance, two fusion performance assessment parameters are defined as Fusion Distance and Fusion Index. Moreover, the formula for calculating the upper bounds of actual fused error covariances of the presented multisensor LE fusers is also provided. Demonstrated with simulation examples, the Fusion Index indicates fuser’s actual fused accuracy and its sensitivity to the sensor orders, as well as its robustness to the accuracy of newly added sensors. Compared to the LE fuser with sequential structure, the LE fusers with proposed parallel structures not only significantly improve their properties in these aspects, but also embrace better performances in consistency and computation efficiency. The presented multisensor LE fusers generally have better accuracies than covariance intersection (CI) fusion algorithm and are consistent when the local estimates are weakly correlated. PMID:28661442

Teenaged Drivers and Fatal Crash Responsibility. Preliminary Report.

ERIC Educational Resources Information Center

Williams, Allan F.; Karpf, Ronald S.

According to data obtained for the year 1978 from the Fatal Accident Reporting System (FARS) and from state governments under contract to the National Highway Traffic Safety Administration, teenaged drivers (especially males) have much higher rates of fatal crash involvement than older drivers. In addition, teenaged drivers are more likely than…

Proposed Generation and Compression of a Target Plasma for MTF

DTIC Science & Technology

1995-07-01

essential ingredient that has been implicit in the quest: a net energy gain. That is, they do not provide more fusion energy than the energy require...to establish the fusion conditions. This points to the primary motivation for the quest, a fusion energy production system. Such a system is

Complications with axial presacral lumbar interbody fusion: A 5-year postmarketing surveillance experience

PubMed Central

Gundanna, Mukund I.; Miller, Larry E.; Block, Jon E.

2011-01-01

Background Open and minimally invasive lumbar fusion procedures have inherent procedural risks, with posterior and transforaminal approaches resulting in significant soft-tissue injury and the anterior approach endangering organs and major blood vessels. An alternative lumbar fusion technique uses a small paracoccygeal incision and a presacral approach to the L5-S1 intervertebral space, which avoids critical structures and may result in a favorable safety profile versus open and other minimally invasive fusion techniques. The purpose of this study was to evaluate complications associated with axial interbody lumbar fusion procedures using the Axial Lumbar Interbody Fusion (AxiaLIF) System (TranS1, Wilmington, North Carolina) in the postmarketing period. Methods Between March 2005 and March 2010, 9,152 patients underwent interbody fusion with the AxiaLIF System through an axial presacral approach. A single-level L5-S1 fusion was performed in 8,034 patients (88%), and a 2-level (L4-S1) fusion was used in 1,118 (12%). A predefined database was designed to record device- or procedure-related complaints via spontaneous reporting. The complications that were recorded included bowel injury, superficial wound and systemic infections, transient intraoperative hypotension, migration, subsidence, presacral hematoma, sacral fracture, vascular injury, nerve injury, and ureter injury. Results Complications were reported in 120 of 9,152 patients (1.3%). The most commonly reported complications were bowel injury (n = 59, 0.6%) and transient intraoperative hypotension (n = 20, 0.2%). The overall complication rate was similar between single-level (n = 102, 1.3%) and 2-level (n = 18, 1.6%) fusion procedures, with no significant differences noted for any single complication. Conclusions The 5-year postmarketing surveillance experience with the AxiaLIF System suggests that axial interbody lumbar fusion through the presacral approach is associated with a low incidence of complications. The overall complication rates observed in our evaluation compare favorably with those reported in trials of open and minimally invasive lumbar fusion surgery. PMID:25802673

A Method to Increase Drivers' Trust in Collision Warning Systems Based on Reliability Information of Sensor

NASA Astrophysics Data System (ADS)

Tsutsumi, Shigeyoshi; Wada, Takahiro; Akita, Tokihiko; Doi, Shun'ichi

Driver's workload tends to be increased during driving under complicated traffic environments like a lane change. In such cases, rear collision warning is effective for reduction of cognitive workload. On the other hand, it is pointed out that false alarm or missing alarm caused by sensor errors leads to decrease of driver' s trust in the warning system and it can result in low efficiency of the system. Suppose that reliability information of the sensor is provided in real-time. In this paper, we propose a new warning method to increase driver' s trust in the system even with low sensor reliability utilizing the sensor reliability information. The effectiveness of the warning methods is shown by driving simulator experiments.

The California corridor transportation system: A design summary

NASA Technical Reports Server (NTRS)

1990-01-01

A design group was assembled to find and research criteria relevent to the design of a California Corridor Transportation System. The efforts of this group included defining the problem, conducting a market analysis, formulation of a demand model, identification and evaluation of design drivers, and the systematic development of a solution. The problems of the current system were analyzed and used to determine design drivers, which were divided into the broad categories of cost, convenience, feasibility, environment, safety, and social impact. The relative importance of individual problems was addressed, resulting in a hierarchy of design drivers. Where possible, methods of evaluating the relative merit of proposed systems with respect to each driver were developed. Short takeoff vertical landing aircraft concepts are also discussed for supersonic fighters.

Double Cluster Heads Model for Secure and Accurate Data Fusion in Wireless Sensor Networks

PubMed Central

Fu, Jun-Song; Liu, Yun

2015-01-01

Secure and accurate data fusion is an important issue in wireless sensor networks (WSNs) and has been extensively researched in the literature. In this paper, by combining clustering techniques, reputation and trust systems, and data fusion algorithms, we propose a novel cluster-based data fusion model called Double Cluster Heads Model (DCHM) for secure and accurate data fusion in WSNs. Different from traditional clustering models in WSNs, two cluster heads are selected after clustering for each cluster based on the reputation and trust system and they perform data fusion independently of each other. Then, the results are sent to the base station where the dissimilarity coefficient is computed. If the dissimilarity coefficient of the two data fusion results exceeds the threshold preset by the users, the cluster heads will be added to blacklist, and the cluster heads must be reelected by the sensor nodes in a cluster. Meanwhile, feedback is sent from the base station to the reputation and trust system, which can help us to identify and delete the compromised sensor nodes in time. Through a series of extensive simulations, we found that the DCHM performed very well in data fusion security and accuracy. PMID:25608211

Airborne Infrared and Visible Image Fusion Combined with Region Segmentation

PubMed Central

Zuo, Yujia; Liu, Jinghong; Bai, Guanbing; Wang, Xuan; Sun, Mingchao

2017-01-01

This paper proposes an infrared (IR) and visible image fusion method introducing region segmentation into the dual-tree complex wavelet transform (DTCWT) region. This method should effectively improve both the target indication and scene spectrum features of fusion images, and the target identification and tracking reliability of fusion system, on an airborne photoelectric platform. The method involves segmenting the region in an IR image by significance, and identifying the target region and the background region; then, fusing the low-frequency components in the DTCWT region according to the region segmentation result. For high-frequency components, the region weights need to be assigned by the information richness of region details to conduct fusion based on both weights and adaptive phases, and then introducing a shrinkage function to suppress noise; Finally, the fused low-frequency and high-frequency components are reconstructed to obtain the fusion image. The experimental results show that the proposed method can fully extract complementary information from the source images to obtain a fusion image with good target indication and rich information on scene details. They also give a fusion result superior to existing popular fusion methods, based on eithers subjective or objective evaluation. With good stability and high fusion accuracy, this method can meet the fusion requirements of IR-visible image fusion systems. PMID:28505137

Airborne Infrared and Visible Image Fusion Combined with Region Segmentation.

PubMed

Zuo, Yujia; Liu, Jinghong; Bai, Guanbing; Wang, Xuan; Sun, Mingchao

2017-05-15

This paper proposes an infrared (IR) and visible image fusion method introducing region segmentation into the dual-tree complex wavelet transform (DTCWT) region. This method should effectively improve both the target indication and scene spectrum features of fusion images, and the target identification and tracking reliability of fusion system, on an airborne photoelectric platform. The method involves segmenting the region in an IR image by significance, and identifying the target region and the background region; then, fusing the low-frequency components in the DTCWT region according to the region segmentation result. For high-frequency components, the region weights need to be assigned by the information richness of region details to conduct fusion based on both weights and adaptive phases, and then introducing a shrinkage function to suppress noise; Finally, the fused low-frequency and high-frequency components are reconstructed to obtain the fusion image. The experimental results show that the proposed method can fully extract complementary information from the source images to obtain a fusion image with good target indication and rich information on scene details. They also give a fusion result superior to existing popular fusion methods, based on eithers subjective or objective evaluation. With good stability and high fusion accuracy, this method can meet the fusion requirements of IR-visible image fusion systems.

Performance of an Additional Task During Level 2 Automated Driving: An On-Road Study Comparing Drivers With and Without Experience With Partial Automation.

PubMed

Solís-Marcos, Ignacio; Ahlström, Christer; Kircher, Katja

2018-05-01

To investigate the influence of prior experience with Level 2 automation on additional task performance during manual and Level 2 partially automated driving. Level 2 automation is now on the market, but its effects on driver behavior remain unclear. Based on previous studies, we could expect an increase in drivers' engagement in secondary tasks during Level 2 automated driving, but it is yet unknown how drivers will integrate all the ongoing demands in such situations. Twenty-one drivers (12 without, 9 with Level 2 automation experience) drove on a highway manually and with Level 2 automation (exemplified by Volvo Pilot Assist generation 2; PA2) while performing an additional task. In half of the conditions, the task could be interrupted (self-paced), and in the other half, it could not (system-paced). Drivers' visual attention, additional task performance, and other compensatory strategies were analyzed. Driving with PA2 led to decreased scores in the additional task and more visual attention to the dashboard. In the self-paced condition, all drivers looked more to the task and perceived a lower mental demand. The drivers experienced with PA2 used the system and the task more than the novice group and performed more overtakings. The additional task interfered more with Level 2 automation than with manual driving. The drivers, particularly the automation novice drivers, used some compensatory strategies. Automation designers need to consider these potential effects in the development of future automated systems.

The Role of Interaction Patterns with Hybrid Electric Vehicle Eco-Features for Drivers' Eco-Driving Performance.

PubMed

Arend, Matthias G; Franke, Thomas

2017-03-01

The objective of the present research was to understand drivers' interaction patterns with hybrid electric vehicles' (HEV) eco-features (electric propulsion, regenerative braking, neutral mode) and their relationship to fuel efficiency and driver characteristics (technical system knowledge, eco-driving motivation). Eco-driving (driving behaviors performed to achieve higher fuel efficiency) has the potential to reduce CO 2 emissions caused by road vehicles. Eco-driving in HEVs is particularly challenging due to the systems' dynamic energy flows. As a result, drivers are likely to show diverse eco-driving behaviors, depending on factors like knowledge and motivation. The eco-features represent an interface for the control of the systems' energy flows. A sample of 121 HEV drivers who had constantly logged their fuel consumption prior to the study participated in an online questionnaire. Drivers' interaction patterns with the eco-features were related to fuel efficiency. A common factor was identified in an exploratory factor analysis, characterizing the intensity of actively dealing with electric energy, which was also related to fuel efficiency. Driver characteristics were not related to this factor, yet they were significant predictors of fuel efficiency. From the perspective of user-energy interaction, the relationship of the aggregated factor to fuel efficiency emphasizes the central role of drivers' perception of and interaction with energy conversions in determining HEV eco-driving success. To arrive at an in-depth understanding of drivers' eco-driving behaviors that can guide interface design, authors of future research should be concerned with the psychological processes that underlie drivers' interaction patterns with eco-features.

Wireless and wearable EEG system for evaluating driver vigilance.

PubMed

Lin, Chin-Teng; Chuang, Chun-Hsiang; Huang, Chih-Sheng; Tsai, Shu-Fang; Lu, Shao-Wei; Chen, Yen-Hsuan; Ko, Li-Wei

2014-04-01

Brain activity associated with attention sustained on the task of safe driving has received considerable attention recently in many neurophysiological studies. Those investigations have also accurately estimated shifts in drivers' levels of arousal, fatigue, and vigilance, as evidenced by variations in their task performance, by evaluating electroencephalographic (EEG) changes. However, monitoring the neurophysiological activities of automobile drivers poses a major measurement challenge when using a laboratory-oriented biosensor technology. This work presents a novel dry EEG sensor based mobile wireless EEG system (referred to herein as Mindo) to monitor in real time a driver's vigilance status in order to link the fluctuation of driving performance with changes in brain activities. The proposed Mindo system incorporates the use of a wireless and wearable EEG device to record EEG signals from hairy regions of the driver conveniently. Additionally, the proposed system can process EEG recordings and translate them into the vigilance level. The study compares the system performance between different regression models. Moreover, the proposed system is implemented using JAVA programming language as a mobile application for online analysis. A case study involving 15 study participants assigned a 90 min sustained-attention driving task in an immersive virtual driving environment demonstrates the reliability of the proposed system. Consistent with previous studies, power spectral analysis results confirm that the EEG activities correlate well with the variations in vigilance. Furthermore, the proposed system demonstrated the feasibility of predicting the driver's vigilance in real time.

Technology and teen drivers.

PubMed

Lee, John D

2007-01-01

The rapid evolution of computing, communication, and sensor technology is likely to affect young drivers more than others. The distraction potential of infotainment technology stresses the same vulnerabilities that already lead young drivers to crash more frequently than other drivers. Cell phones, text messaging, MP3 players, and other nomadic devices all present a threat because young drivers may lack the spare attentional capacity for vehicle control and the ability to anticipate and manage hazards. Moreover, young drivers are likely to be the first and most aggressive users of new technology. Fortunately, emerging technology can also support safe driving. Electronic stability control, collision avoidance systems, intelligent speed adaptation, and vehicle tracking systems can all help mitigate the threats to young drivers. However, technology alone is unlikely to make young drivers safer. One promising approach to tailoring technology to teen drivers is to extend proven methods for enhancing young driver safety. The success of graduated drivers license programs (GDL) and the impressive safety benefit of supervised driving suggest ways of tailoring technology to the needs of young drivers. To anticipate the effects of technology on teen driving it may be useful to draw an analogy between the effects of passengers and the effects of technology. Technology can act as a teen passenger and undermine safety or it can act as an adult passenger and enhance safety. Rapidly developing technology may have particularly large effects on teen drivers. To maximize the positive effects and minimize the negative effects will require a broad range of industries to work together. Ideally, vehicle manufacturers would work with infotainment providers, insurance companies, and policy makers to craft new technologies so that they accommodate the needs of young drivers. Without such collaboration young drivers will face even greater challenges to their safety as new technologies emerge.

A National Evaluation of the Nighttime and Passenger Restriction Components of Graduated Driver Licensing

PubMed Central

Fell, James C.; Todd, Michael; Voas, Robert B.

2011-01-01

Introduction The high crash rate of youthful novice drivers has been recognized for half a century. Over the last decade, graduated driver licensing (GDL) systems, which extend the period of supervised driving and limit the novice’s exposure to higher-risk conditions (such as nighttime driving) has effectively reduced crash involvements of novice drivers. Method This study used data from the Fatality Analysis Reporting System (FARS) and the implementation dates of GDL laws in a state-by-year panel study to evaluate the effectiveness of two key elements of GDL laws: nighttime restrictions and passenger limitations. Results Nighttime restrictions were found to reduce 16- and 17-year-old driver involvements in nighttime fatal crashes by an estimated 10% and 16- and 17-year-old drinking drivers in nighttime fatal crashes by 13%. Passenger restrictions were found to reduce 16- and 17-year-old driver involvements in fatal crashes with teen passengers by an estimated 9%. Conclusions These results confirm the effectiveness of these provisions in GDL systems. Impact on Public Health The results of this study indicate that nighttime restrictions and passenger limitations are very important components of any GDL law. PMID:22017831

Parental perceptions of the learner driver log book system in two Australian states.

PubMed

Bates, Lyndel; Watson, Barry; King, Mark Johann

2014-01-01

Though many jurisdictions internationally now require learner drivers to complete a specified number of hours of supervised driving practice before being able to drive unaccompanied, very few require learner drivers to complete a log book to record this practice and then present it to the licensing authority. Learner drivers in most Australian jurisdictions must complete a log book that records their practice, thereby confirming to the licensing authority that they have met the mandated hours of practice requirement. These log books facilitate the management and enforcement of minimum supervised hours of driving requirements. Parents of learner drivers in 2 Australian states, Queensland and New South Wales, completed an online survey assessing a range of factors, including their perceptions of the accuracy of their child's learner log book and the effectiveness of the log book system. The study indicates that the large majority of parents believe that their child's learner log book is accurate. However, they generally report that the log book system is only moderately effective as a system to measure the number of hours of supervised practice a learner driver has completed. The results of this study suggest the presence of a paradox, with many parents possibly believing that others are not as diligent in the use of log books as they are or that the system is too open to misuse. Given that many parents report that their child's log book is accurate, this study has important implications for the development and ongoing monitoring of hours of practice requirements in graduated driver licensing systems.

49 CFR 570.54 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-10-01

... from the driver control to a hydraulic brake system to actuate the service brakes. Electric brake system means a system that uses electric current to actuate the service brake. Vacuum brake system means a system that uses a vacuum and atmospheric pressure for transmitting a force from the driver...

49 CFR 570.54 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-10-01

... from the driver control to a hydraulic brake system to actuate the service brakes. Electric brake system means a system that uses electric current to actuate the service brake. Vacuum brake system means a system that uses a vacuum and atmospheric pressure for transmitting a force from the driver...

Low-energy nuclear reaction of the 14N+169Tm system: Incomplete fusion

NASA Astrophysics Data System (ADS)

Kumar, R.; Sharma, Vijay R.; Yadav, Abhishek; Singh, Pushpendra P.; Agarwal, Avinash; Appannababu, S.; Mukherjee, S.; Singh, B. P.; Ali, R.; Bhowmik, R. K.

2017-11-01

Excitation functions of reaction residues produced in the 14N+169Tm system have been measured to high precision at energies above the fusion barrier, ranging from 1.04 VB to 1.30 VB , and analyzed in the framework of the statistical model code pace4. Analysis of α -emitting channels points toward the onset of incomplete fusion even at slightly above-barrier energies where complete fusion is supposed to be one of the dominant processes. The onset and strength of incomplete fusion have been deduced and studied in terms of various entrance channel parameters. Present results together with the reanalysis of existing data for various projectile-target combinations conclusively suggest strong influence of projectile structure on the onset of incomplete fusion. Also, a strong dependence on the Coulomb effect (ZPZT) has been observed for the present system along with different projectile-target combinations available in the literature. It is concluded that the fraction of incomplete fusion linearly increases with ZPZT and is found to be more for larger ZPZT values, indicating significantly important linear systematics.

Proposed evaluation framework for assessing operator performance with multisensor displays

NASA Technical Reports Server (NTRS)

Foyle, David C.

1992-01-01

Despite aggressive work on the development of sensor fusion algorithms and techniques, no formal evaluation procedures have been proposed. Based on existing integration models in the literature, an evaluation framework is developed to assess an operator's ability to use multisensor, or sensor fusion, displays. The proposed evaluation framework for evaluating the operator's ability to use such systems is a normative approach: The operator's performance with the sensor fusion display can be compared to the models' predictions based on the operator's performance when viewing the original sensor displays prior to fusion. This allows for the determination as to when a sensor fusion system leads to: 1) poorer performance than one of the original sensor displays (clearly an undesirable system in which the fused sensor system causes some distortion or interference); 2) better performance than with either single sensor system alone, but at a sub-optimal (compared to the model predictions) level; 3) optimal performance (compared to model predictions); or, 4) super-optimal performance, which may occur if the operator were able to use some highly diagnostic 'emergent features' in the sensor fusion display, which were unavailable in the original sensor displays. An experiment demonstrating the usefulness of the proposed evaluation framework is discussed.

Automated Driving System Architecture to Ensure Safe Delegation of Driving Authority

NASA Astrophysics Data System (ADS)

YUN, Sunkil; NISHIMURA, Hidekazu

2016-09-01

In this paper, the architecture of an automated driving system (ADS) is proposed to ensure safe delegation of driving authority between the ADS and a driver. Limitations of the ADS functions may activate delegation of driving authority to a driver. However, it leads to severe consequences in emergency situations where a driver may be drowsy or distracted. To address these issues, first, the concept model for the ADS in the situation for delegation of driving authority is described taking the driver's behaviour and state into account. Second, the behaviour / state of a driver and functional flow / state of ADS and the interactions between them are modelled to understand the context where the ADS requests to delegate the driving authority to a driver. Finally, the proposed architecture of the ADS is verified under the simulations based on the emergency braking scenarios. In the verification process using simulation, we have derived the necessary condition for safe delegation of driving authority is that the ADS should assist s driver even after delegating driving authority to a driver who has not enough capability to regain control of the driving task.

Laser or charged-particle-beam fusion reactor with direct electric generation by magnetic flux compression

DOEpatents

Lasche, George P.

1988-01-01

A high-power-density laser or charged-particle-beam fusion reactor system maximizes the directed kinetic energy imparted to a large mass of liquid lithium by a centrally located fusion target. A fusion target is embedded in a large mass of lithium, of sufficient radius to act as a tritium breeding blanket, and provided with ports for the access of beam energy to implode the target. The directed kinetic energy is converted directly to electricity with high efficiency by work done against a pulsed magnetic field applied exterior to the lithium. Because the system maximizes the blanket thickness per unit volume of lithium, neutron-induced radioactivities in the reaction chamber wall are several orders of magnitude less than is typical of other fusion reactor systems.

Data fusion algorithm for rapid multi-mode dust concentration measurement system based on MEMS

NASA Astrophysics Data System (ADS)

Liao, Maohao; Lou, Wenzhong; Wang, Jinkui; Zhang, Yan

2018-03-01

As single measurement method cannot fully meet the technical requirements of dust concentration measurement, the multi-mode detection method is put forward, as well as the new requirements for data processing. This paper presents a new dust concentration measurement system which contains MEMS ultrasonic sensor and MEMS capacitance sensor, and presents a new data fusion algorithm for this multi-mode dust concentration measurement system. After analyzing the relation between the data of the composite measurement method, the data fusion algorithm based on Kalman filtering is established, which effectively improve the measurement accuracy, and ultimately forms a rapid data fusion model of dust concentration measurement. Test results show that the data fusion algorithm is able to realize the rapid and exact concentration detection.

Laser or charged-particle-beam fusion reactor with direct electric generation by magnetic flux compression

DOEpatents

Lasche, G.P.

1987-02-20

A high-power-density-laser or charged-particle-beam fusion reactor system maximizes the directed kinetic energy imparted to a large mass of liquid lithium by a centrally located fusion target. A fusion target is embedded in a large mass of lithium, of sufficient radius to act as a tritium breeding blanket, and provided with ports for the access of beam energy to implode the target. The directed kinetic energy is converted directly to electricity with high efficiency by work done against a pulsed magnetic field applied exterior to the lithium. Because the system maximizes the blanket thickness per unit volume of lithium, neutron-induced radioactivities in the reaction chamber wall are several orders of magnitude less than is typical of other fusion reactor systems. 25 figs.

The effects of driver identity on driving safety in a retrospective feedback system.

PubMed

Zhao, Guozhen; Wu, Changxu

2012-03-01

Retrospective feedback that provides detailed information on a driver's performance in critical driving situations at the end of a trip enhances his/her driving behaviors and safe driving habits. Although this has been demonstrated by a previous study, retrospective feedback can be further improved and applied to non-critical driving situations, which is needed for transportation safety. To propose a new retrospective feedback system that uses driver identity (i.e., a driver's name) and to experimentally study its effects on measures of driving performance and safety in a driving simulator. We conducted a behavioral experimental study with 30 participants. "Feedback type" was a between-subject variable with three conditions: no feedback (control group), feedback without driver identity, and feedback with driver identity. We measured multiple aspects of participants' driving behavior. To control for potential confounds, factors that were significantly correlated with driving behavior (e.g., age and driving experience) were all entered as covariates into a multivariate analysis of variance. To examine the effects of speeding on collision severity in driving simulation studies, we also developed a new index - momentum of potential collision - with a set of equations. Subjects who used a feedback system with driver identity had the fewest speeding violations and central-line crossings, spent the least amount of time speeding and crossing the central line, had the lowest speeding and central-line crossing magnitude, ran the fewest red lights, and had the smallest momentum of potential collision compared to the groups with feedback without driver identity and without feedback (control group). The new retrospective feedback system with driver identity has the potential to enhance a person's driving safety (e.g., speeding, central-line crossing, momentum of potential collision), which is an indication of the valence of one's name in a feedback system design. Copyright © 2011 Elsevier Ltd. All rights reserved.

Preliminary result of rapid solenoid for controlling heavy-ion beam parameters of laser ion source

DOE PAGES

Okamura, M.; Sekine, M.; Ikeda, S.; ...

2015-03-13

To realize a heavy ion inertial fusion driver, we have studied a possibility of laser ion source (LIS). A LIS can provide high current high brightness heavy ion beams, however it was difficult to manipulate the beam parameters. To overcome the issue, we employed a pulsed solenoid in the plasma drift section and investigated the effect of the solenoid field on singly charged iron beams. The rapid ramping magnetic field could enhance limited time slice of the current and simultaneously the beam emittance changed accordingly. This approach may also useful to realize an ion source for HIF power plant.

Driver fatigue alarm based on eye detection and gaze estimation

NASA Astrophysics Data System (ADS)

Sun, Xinghua; Xu, Lu; Yang, Jingyu

2007-11-01

The driver assistant system has attracted much attention as an essential component of intelligent transportation systems. One task of driver assistant system is to prevent the drivers from fatigue. For the fatigue detection it is natural that the information about eyes should be utilized. The driver fatigue can be divided into two types, one is the sleep with eyes close and another is the sleep with eyes open. Considering that the fatigue detection is related with the prior knowledge and probabilistic statistics, the dynamic Bayesian network is used as the analysis tool to perform the reasoning of fatigue. Two kinds of experiments are performed to verify the system effectiveness, one is based on the video got from the laboratory and another is based on the video got from the real driving situation. Ten persons participate in the test and the experimental result is that, in the laboratory all the fatigue events can be detected, and in the practical vehicle the detection ratio is about 85%. Experiments show that in most of situations the proposed system works and the corresponding performance is satisfying.

Drivers license display system

NASA Astrophysics Data System (ADS)

Prokoski, Francine J.

1997-01-01

Carjackings are only one of a growing class of law enforcement problems associated with increasingly violent crimes and accidents involving automobiles plays weapons, drugs and alcohol. Police traffic stops have become increasingly dangerous, with an officer having no information about a vehicle's potentially armed driver until approaching him. There are 15 million alcoholics in the US and 90 percent of them have drivers licenses. Many of them continue driving even after their licenses have ben revoked or suspended. There are thousands of unlicensed truck drivers in the country, and also thousands who routinely exceed safe operating periods without rest; often using drugs in an attempt to stay alert. MIKOS has developed the Drivers License Display Systems to reduce these and other related risks. Although every state requires the continuous display of vehicle registration information on every vehicle using public roads, no state yet requires the display of driver license information. The technology exists to provide that feature as an add-on to current vehicles for nominal cost. An initial voluntary market is expected to include: municipal, rental, and high value vehicles which are most likely to be mis-appropriated. It is anticipated that state regulations will eventually require such systems in the future, beginning with commercial vehicles, and then extending to high risk drivers and eventually all vehicles. The MIKOS system offers a dual-display approach which can be deployed now, and which will utilize all existing state licenses without requiring standardization.

An Overview of INEL Fusion Safety R&D Facilities

NASA Astrophysics Data System (ADS)

McCarthy, K. A.; Smolik, G. R.; Anderl, R. A.; Carmack, W. J.; Longhurst, G. R.

1997-06-01

The Fusion Safety Program at the Idaho National Engineering Laboratory has the lead for fusion safety work in the United States. Over the years, we have developed several experimental facilities to provide data for fusion reactor safety analyses. We now have four major experimental facilities that provide data for use in safety assessments. The Steam-Reactivity Measurement System measures hydrogen generation rates and tritium mobilization rates in high-temperature (up to 1200°C) fusion relevant materials exposed to steam. The Volatilization of Activation Product Oxides Reactor Facility provides information on mobilization and transport and chemical reactivity of fusion relevant materials at high temperature (up to 1200°C) in an oxidizing environment (air or steam). The Fusion Aerosol Source Test Facility is a scaled-up version of VAPOR. The ion-implanta-tion/thermal-desorption system is dedicated to research into processes and phenomena associated with the interaction of hydrogen isotopes with fusion materials. In this paper we describe the capabilities of these facilities.

Multimodal biometric system using rank-level fusion approach.

PubMed

Monwar, Md Maruf; Gavrilova, Marina L

2009-08-01

In many real-world applications, unimodal biometric systems often face significant limitations due to sensitivity to noise, intraclass variability, data quality, nonuniversality, and other factors. Attempting to improve the performance of individual matchers in such situations may not prove to be highly effective. Multibiometric systems seek to alleviate some of these problems by providing multiple pieces of evidence of the same identity. These systems help achieve an increase in performance that may not be possible using a single-biometric indicator. This paper presents an effective fusion scheme that combines information presented by multiple domain experts based on the rank-level fusion integration method. The developed multimodal biometric system possesses a number of unique qualities, starting from utilizing principal component analysis and Fisher's linear discriminant methods for individual matchers (face, ear, and signature) identity authentication and utilizing the novel rank-level fusion method in order to consolidate the results obtained from different biometric matchers. The ranks of individual matchers are combined using the highest rank, Borda count, and logistic regression approaches. The results indicate that fusion of individual modalities can improve the overall performance of the biometric system, even in the presence of low quality data. Insights on multibiometric design using rank-level fusion and its performance on a variety of biometric databases are discussed in the concluding section.

A New Approach to Image Fusion Based on Cokriging

NASA Technical Reports Server (NTRS)

Memarsadeghi, Nargess; LeMoigne, Jacqueline; Mount, David M.; Morisette, Jeffrey T.

2005-01-01

We consider the image fusion problem involving remotely sensed data. We introduce cokriging as a method to perform fusion. We investigate the advantages of fusing Hyperion with ALI. The evaluation is performed by comparing the classification of the fused data with that of input images and by calculating well-chosen quantitative fusion quality metrics. We consider the Invasive Species Forecasting System (ISFS) project as our fusion application. The fusion of ALI with Hyperion data is studies using PCA and wavelet-based fusion. We then propose utilizing a geostatistical based interpolation method called cokriging as a new approach for image fusion.

Associations of distraction involvement and age with driver injury severities.

PubMed

Donmez, Birsen; Liu, Zishu

2015-02-01

This paper investigates the associations between the severity of injuries sustained by a driver who is involved in a two-vehicle crash, the existence and type of driver distraction as well as driver's age. Few studies investigated distraction as it relates to injury severity. Moreover, these studies did not consider driver age which is a significant factor related to driving behavior and the ability to respond in a crash situation. An ordered logit model was built to predict injury severity sustained by drivers using data from the U.S. National Automotive Sampling System's General Estimates System (2003 to 2008). Various factors (e.g., weather, gender, and speeding) were statistically controlled for, but the main focus was on the interaction of driver age and distraction type. The trends observed for young and mid-age drivers were similar. For these age groups, dialing or texting on the cell phone, passengers, and in-vehicle sources resulted in an increase in a likelihood of more severe injuries. Talking on the cell phone had a similar effect for younger drivers but was not significant for mid-age drivers. Inattention and distractions outside the vehicle decreased the odds of severe injuries. For older drivers, the highest odds of severe injuries were observed with dialing or texting on a cell phone, followed by in-vehicle sources and talking on the cell phone. All these sources were associated with an increased likelihood of injury severity. Similar to young and mid-age drivers, distractions outside the vehicle decreased the odds of severe injuries. Other distraction types did not have a significant effect for the older age group. The results support previous literature and extend our understanding of crash injury severity. The findings have implications for policy making and the design of distraction mitigation systems. Copyright © 2014 National Safety Council and Elsevier Ltd. All rights reserved.

Spin distribution of evaporation residues formed in complete and incomplete fusion in 16O+154Sm system

NASA Astrophysics Data System (ADS)

Singh, D.; Linda, Sneha B.; Giri, Pankaj K.; Mahato, Amritraj; Tripathi, R.; Kumar, Harish; Afzal Ansari, M.; Sathik, N. P. M.; Ali, Rahbar; Kumar, Rakesh; Muralithar, S.; Singh, R. P.

2017-11-01

Spin distributions for several evaporation residues populated in the 16O+154Sm system have been measured at projectile energy ≈ 6.2 MeV/A by using the charged particle-γ-coincidence technique. The measured spin distributions of the evaporation residues populated through incomplete fusion associated with 'fast' α and 2α-emission channels are found to be entirely different from fusion-evaporation channels. It is observed that the mean input angular momentum for the evaporation residues formed in incomplete fusion channel is relatively higher than that observed for evaporation residues in complete fusion channels. The feeding intensity profile of evaporation residues populated through complete fusion and incomplete fusion have also been studied. The incomplete fusion channels are found to have narrow range feeding only for high spin states, while complete fusion channels are strongly fed over a broad spin range and widely populated. Comparison of present results with earlier data suggests that the mean input angular momentum values are relatively smaller for spherical target than that of deformed target using the same projectile and incident energy highlighting the role of target deformation in incomplete fusion dynamics.

Modeling of Steer-by-Wire System Used in New Braking Handwheel Concept

NASA Astrophysics Data System (ADS)

Messaoudène, K.; Oufroukh, N. Ait; Mammar, S.

2008-06-01

The handwheel is one of the primary control mechanisms of automobile thus interaction between the handwheel and the driver is critical to safety. The driver applies forces that direct the vehicle while the handwheel communicates feedback information to the driver of the forces experience by the car within its environment. The handwheel also provides a predictable mechanical feel to the driver to allow smooth and safe control. Many researchers tried to reproduce this feeling by creating steer-by-wire systems. This paper explores this new concept of handwheel and it describes the modeling steps of the components including the restitution mechanism for force feedback and its various links with the vehicle lateral dynamics and the pneumatic contacts. The aim is to explore the possibility to combine a braking device within the steer-by-wire system in order to provide a more suitable and ergonomic device to the driver.

Collision Avoidance, Driver Support and Safety Intervention Systems

NASA Astrophysics Data System (ADS)

Gilling, Simon P.

Autonomous Intelligent Cruise Control (AICC) will be marketed by a number of vehicle manufacturers before the end of the decade. This paper will describe AICC and the next generation systems currently being developed and validated within the EC Fourth Framework project, Anti-Collision Autonomous Support and Safety Intervention SysTem (AC ASSIST).The currently available cruise control systems which maintain a fixed speed are a well-known form of longitudinal driver support. The fixed speed cruise control becomes less useful with increased traffic volumes, as the driver must disable the system when a slower preceding vehicle is encountered.

Drunk driving warning system (DDWS). Volume 1, System concept and description

DOT National Transportation Integrated Search

1983-11-01

The Drunk Driving Warning System (DDWS) is a vehicle-mounted device for testing driver impairment and activating alarms. The driver must pass a steering competency test in order to drive the car in a normal manner. The emergency flasher system operat...

A trainable decisions-in decision-out (DEI-DEO) fusion system

NASA Astrophysics Data System (ADS)

Dasarathy, Belur V.

1998-03-01

Most of the decision fusion systems proposed hitherto in the literature for multiple data source (sensor) environments operate on the basis of pre-defined fusion logic, be they crisp (deterministic), probabilistic, or fuzzy in nature, with no specific learning phase. The fusion systems that are trainable, i.e., ones that have a learning phase, mostly operate in the features-in-decision-out mode, which essentially reduces the fusion process functionally to a pattern classification task in the joint feature space. In this study, a trainable decisions-in-decision-out fusion system is described which estimates a fuzzy membership distribution spread across the different decision choices based on the performance of the different decision processors (sensors) corresponding to each training sample (object) which is associated with a specific ground truth (true decision). Based on a multi-decision space histogram analysis of the performance of the different processors over the entire training data set, a look-up table associating each cell of the histogram with a specific true decision is generated which forms the basis for the operational phase. In the operational phase, for each set of decision inputs, a pointer to the look-up table learnt previously is generated from which a fused decision is derived. This methodology, although primarily designed for fusing crisp decisions from the multiple decision sources, can be adapted for fusion of fuzzy decisions as well if such are the inputs from these sources. Examples, which illustrate the benefits and limitations of the crisp and fuzzy versions of the trainable fusion systems, are also included.

Potential for driver attention monitoring system development

DOT National Transportation Integrated Search

1984-02-08

The following document provides an overview of the potential value of research : into driver attentional processes. Section 1 outlines the status of this research : into driver attentional processes and provides capsule descriptions of the : physical...

Driver performance measurement and analysis system (DPMAS). Volume 1, Description and operations manual

DOT National Transportation Integrated Search

1976-08-01

A prototype driver performance measurement and analysis system (DPMAS) has been developed for the National Highway Traffic Safety Administration (NHTSA). This system includes a completely instrumented 1974 Chevrolet Impala capable of digitally record...

Introduction to current and future protein therapeutics: a protein engineering perspective.

PubMed

Carter, Paul J

2011-05-15

Protein therapeutics and its enabling sister discipline, protein engineering, have emerged since the early 1980s. The first protein therapeutics were recombinant versions of natural proteins. Proteins purposefully modified to increase their clinical potential soon followed with enhancements derived from protein or glycoengineering, Fc fusion or conjugation to polyethylene glycol. Antibody-based drugs subsequently arose as the largest and fastest growing class of protein therapeutics. The rationale for developing better protein therapeutics with enhanced efficacy, greater safety, reduced immunogenicity or improved delivery comes from the convergence of clinical, scientific, technological and commercial drivers that have identified unmet needs and provided strategies to address them. Future protein drugs seem likely to be more extensively engineered to improve their performance, e.g., antibodies and Fc fusion proteins with enhanced effector functions or extended half-life. Two old concepts for improving antibodies, namely antibody-drug conjugates and bispecific antibodies, have advanced to the cusp of clinical success. As for newer protein therapeutic platform technologies, several engineered protein scaffolds are in early clinical development and offer differences and some potential advantages over antibodies. Copyright © 2011 Elsevier Inc. All rights reserved.