Downregulation of Glutamine Synthetase via GLAST Suppression Induces Retinal Axonal Swelling in a Rat Ex Vivo Hydrostatic Pressure Model

PubMed Central

Yoshitomi, Takeshi; Zorumski, Charles F.; Izumi, Yukitoshi

2011-01-01

Purpose. High levels of glutamate can be toxic to retinal GCs. Thus, effective buffering of extracellular glutamate is important in preserving retinal structure and function. GLAST, a major glutamate transporter in the retina, and glutamine synthetase (GS) regulate extracellular glutamate accumulation and prevent excitotoxicity. This study was an examination of changes in function and expression of GLAST and GS in ex vivo rat retinas exposed to acute increases in ambient pressure. Methods. Ex vivo rat retinas were exposed to elevated hydrostatic pressure for 24 hours. The expression of GLAST and GS were examined using immunochemistry and real-time PCR analysis. Also examined were the effects of (2S,3S)-3-[3-[4-(trifluoromethyl) benzoylamino] benzyloxy] aspartate (TFB-TBOA), an inhibitor of glutamate transporters, and l-methionine-S-sulfoximine (MSO), an inhibitor of GS. Results. In this acute model, Western blot and real-time RT-PCR analyses revealed that substantially (75 mm Hg), but not moderately (35 mm Hg), elevated pressure depressed GLAST expression, diminished GS activity, and induced axonal swelling between the GC layer and the inner limiting membrane. However, at the moderately elevated pressure (35 mm Hg), administration of either TFB-TBOA or MSO also induced axonal swelling and excitotoxic neuronal damage. MSO did not depress GLAST expression but TFB-TBOA significantly suppressed GS, suggesting that downregulation of GS during pressure loading may result from impaired GLAST expression. Conclusions. The retina is at risk during acute intraocular pressure elevation due to downregulation of GS activity resulting from depressed GLAST expression. PMID:21775659

Downregulation of glutamine synthetase via GLAST suppression induces retinal axonal swelling in a rat ex vivo hydrostatic pressure model.

PubMed

Ishikawa, Makoto; Yoshitomi, Takeshi; Zorumski, Charles F; Izumi, Yukitoshi

2011-08-22

PURPOSE. High levels of glutamate can be toxic to retinal GCs. Thus, effective buffering of extracellular glutamate is important in preserving retinal structure and function. GLAST, a major glutamate transporter in the retina, and glutamine synthetase (GS) regulate extracellular glutamate accumulation and prevent excitotoxicity. This study was an examination of changes in function and expression of GLAST and GS in ex vivo rat retinas exposed to acute increases in ambient pressure. METHODS. Ex vivo rat retinas were exposed to elevated hydrostatic pressure for 24 hours. The expression of GLAST and GS were examined using immunochemistry and real-time PCR analysis. Also examined were the effects of (2S,3S)-3-[3-[4-(trifluoromethyl) benzoylamino] benzyloxy] aspartate (TFB-TBOA), an inhibitor of glutamate transporters, and l-methionine-S-sulfoximine (MSO), an inhibitor of GS. RESULTS. In this acute model, Western blot and real-time RT-PCR analyses revealed that substantially (75 mm Hg), but not moderately (35 mm Hg), elevated pressure depressed GLAST expression, diminished GS activity, and induced axonal swelling between the GC layer and the inner limiting membrane. However, at the moderately elevated pressure (35 mm Hg), administration of either TFB-TBOA or MSO also induced axonal swelling and excitotoxic neuronal damage. MSO did not depress GLAST expression but TFB-TBOA significantly suppressed GS, suggesting that downregulation of GS during pressure loading may result from impaired GLAST expression. CONCLUSIONS. The retina is at risk during acute intraocular pressure elevation due to downregulation of GS activity resulting from depressed GLAST expression.

Force Measurement on the GLAST Delta II Flight

NASA Technical Reports Server (NTRS)

Gordon, Scott; Kaufman, Daniel

2009-01-01

This viewgraph presentation reviews the interface force measurement at spacecraft separation of GLAST Delta II. The contents include: 1) Flight Force Measurement (FFM) Background; 2) Team Members; 3) GLAST Mission Overview; 4) Methodology Development; 5) Ground Test Validation; 6) Flight Data; 7) Coupled Loads Simulation (VCLA & Reconstruction); 8) Basedrive Simulation; 9) Findings; and 10) Summary and Conclusions.

Assessment of Glutamate Transporter GLAST (EAAT1)-Deficient Mice for Phenotypes Relevant to the Negative and Executive/Cognitive Symptoms of Schizophrenia

PubMed Central

Karlsson, Rose-Marie; Tanaka, Kohichi; Saksida, Lisa M; Bussey, Timothy J; Heilig, Markus; Holmes, Andrew

2012-01-01

Glutamatergic dysfunction is increasingly implicated in the pathophysiology of schizophrenia. Current models postulate that dysfunction of glutamate and its receptors underlie many of the symptoms in this disease. However, the mechanisms involved are not well understood. Although elucidating the role for glutamate transporters in the disease has been limited by the absence of pharmacological tools that selectively target the transporter, we recently showed that glial glutamate and aspartate transporter (GLAST; excitatory amino-acid transporter 1) mutant mice exhibit abnormalities on behavioral measures thought to model the positive symptoms of schizophrenia, some of which were rescued by treatment with either haloperidol or the mGlu2/3 agonist, LY379268 the mGlu2/3 agonist, LY379268. To further determine the role of GLAST in schizophrenia-related behaviors we tested GLAST mutant mice on a series of behavioral paradigms associated with the negative (social withdrawal, anhedonia), sensorimotor gating (prepulse inhibition of startle), and executive/cognitive (discrimination learning, extinction) symptoms of schizophrenia. GLAST knockout (KO) mice showed poor nesting behavior and abnormal sociability, whereas KO and heterozygous (HET) both demonstrated lesser preference for a novel social stimulus compared to wild-type littermate controls. GLAST KO, but not HET, had a significantly reduced acoustic startle response, but no significant deficit in prepulse inhibition of startle. GLAST KO and HET showed normal sucrose preference. In an instrumental visual discrimination task, KO showed impaired learning. By contrast, acquisition and extinction of a simple instrumental response was normal. The mGlu2/3 agonist, LY379268, failed to rescue the discrimination impairment in KO mice. These findings demonstrate that gene deletion of GLAST produces select phenotypic abnormalities related to the negative and cognitive symptoms of schizophrenia. PMID:19078949

Blazar Duty-Cycle at Gamma-Ray Frequecies: Constraints From Extragalactic Background Radiation And Prospects for AGILE And GLAST

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pittori, Carlotta; Cavazzuti, Elisabetta; Colafrancesco, Sergio

2011-11-29

We take into account the constraints from the observed extragalactic {gamma}-ray background to estimate the maximum duty cycle allowed for a selected sample of WMAP Blazars, in order to be detectable by AGILE and GLAST {gamma}-ray experiments. For the nominal sensitivity values of both instruments, we identify a subset of sources which can in principle be detectable also in a steady state without over-predicting the extragalactic background. This work is based on the results of a recently derived Blazar radio LogN-LogS obtained by combining several multi-frequency surveys.

Exploring the High Energy Universe: GLAST Mission and Science

NASA Technical Reports Server (NTRS)

McEnery, Julie

2007-01-01

GLAST, the Gamma-Ray Large Area Space Telescope, is NASA's next-generation high-energy gamma-ray satellite scheduled for launch in Autumn 2007. GLAST will allow measurements of cosmic gamma-ray sources in the 10 MeV to 100 GeV energy band to be made with unprecedented sensitivity. Amongst its key scientific objectives are to understand particle acceleration in Active Galactic Nuclei, Pulsars and Supernovae Remnants, to provide high resolution measurements of unidentified gamma-ray sources, to study transient high energy emission from objects such as gamma-ray bursts, and to probe Dark Matter and the early Universe. Dr. McEnery will present an overview of the GLAST mission and its scientific goals.

GLAST answers about high-energy peaked BL Lacs: double-humped {gamma}-ray peak and extreme accelerators?

DOE Office of Scientific and Technical Information (OSTI.GOV)

Costamante, L.; Aharonian, F.; Khangulyan, D.

2007-07-12

An often overlooked fact is that the MeV-GeV emission from High-energy peaked BL Lacs (HBL) is basically unknown: there are only 3 objects of this type among all EGRET identified blazars with measured spectra. GLAST will be able to measure the spectrum for many of them, in particular TeV-blazars, and surprises are expected. GLAST will tell if the {gamma}-ray peak in some HBL is actually a ''double peak'', as suggested by the comparison of EGRET and HESS data in PKS 2155-304, We also remind and argue that a new class of BL Lacs could exist, where particles are shock-accelerated nearmore » the maximum possible rate, characterized by the synchrotron emission peaking in the GLAST band (100 MeV - few GeV). Such objects could easily have escaped detection or identification so far, and could now be unveiled by GLAST.« less

Exploring the High Energy Universe: GLAST Mission and Science

NASA Technical Reports Server (NTRS)

McEnery, Julie

2007-01-01

GLAST, the Gamma-Ray Large Area Space Telescope, is NASA's next-generation high-energy gamma-ray satellite scheduled for launch in Autumn 2007. GLAST will allow measurements of cosmic gamma-ray sources in t he 10 MeV to 100 GeV energy band to be made with unprecedented sensi tivity. Amongst its key scientific objectives are to understand part icle acceleration in Active Galactic Nuclei, Pulsars and Supernovae Remnants, to provide high resolution measurements of unidentified ga mma-ray sources, to study transient high energy emission from objects such as gamma-ray bursts, and to probe Dark Matter and the early Uni verse. Dr. McEnery will present an overview of the GLAST mission and its scientific goals.

Real-Time Visualization of Spacecraft Telemetry for the GLAST and LRO Missions

NASA Technical Reports Server (NTRS)

Stoneking, Eric T.; Shah, Neerav; Chai, Dean J.

2010-01-01

GlastCam and LROCam are closely-related tools developed at NASA Goddard Space Flight Center for real-time visualization of spacecraft telemetry, developed for the Gamma-Ray Large Area Space Telescope (GLAST) and Lunar Reconnaissance Orbiter (LRO) missions, respectively. Derived from a common simulation tool, they use related but different architectures to ingest real-time spacecraft telemetry and ground predicted ephemerides, and to compute and display features of special interest to each mission in its operational environment. We describe the architectures of GlastCam and LROCam, the customizations required to fit into the mission operations environment, and the features that were found to be especially useful in early operations for their respective missions. Both tools have a primary window depicting a three-dimensional Cam view of the spacecraft that may be freely manipulated by the user. The scene is augmented with fields of view, pointing constraints, and other features which enhance situational awareness. Each tool also has another "Map" window showing the spacecraft's groundtrack projected onto a map of the Earth or Moon, along with useful features such as the Sun, eclipse regions, and TDRS satellite locations. Additional windows support specialized checkout tasks. One such window shows the star tracker fields of view, with tracking window locations and the mission star catalog. This view was instrumental for GLAST in quickly resolving a star tracker mounting polarity issue; visualization made the 180-deg mismatch immediately obvious. Full access to GlastCam's source code also made possible a rapid coarse star tracker mounting calibration with some on the fly code adjustments; adding a fine grid to measure alignment offsets, and introducing a calibration quaternion which could be adjusted within GlastCam without perturbing the flight parameters. This calibration, from concept to completion, took less than half an hour. Both GlastCam and LROCam were developed in the C language, with non-proprietary support libraries, for ease of customization and portability. This no-blackboxes aspect enables engineers to adapt quickly to unforeseen circumstances in the intense operations environment. GlastCam and LROCam were installed on multiple workstations in the operations support rooms, allowing independent use by multiple subsystems, systems engineers and managers, with negligible draw on telemetry system resources.

New Results on High Energy Cosmic Ray Electrons Observed with Fermi LAT and Their Implications on the Models of Pulsars

NASA Technical Reports Server (NTRS)

Moiseev, Alexander

2010-01-01

This viewgraph presentation describes, in detail, the Fermi Large Area Telescope (LAT) and GLAST Burst Monitor (GBM). Observations made from the June 11, 2008 launch and a discussion of observations made of high energy cosmic ray electrons is also presented.

Data acquisition system issues for large experiments

NASA Astrophysics Data System (ADS)

Siskind, E. J.

2007-09-01

This talk consists of personal observations on two classes of data acquisition ("DAQ") systems for Silicon trackers in large experiments with which the author has been concerned over the last three or more years. The first half is a classic "lessons learned" recital based on experience with the high-level debug and configuration of the DAQ system for the GLAST LAT detector. The second half is concerned with a discussion of the promises and pitfalls of using modern (and future) generations of "system-on-a-chip" ("SOC") or "platform" field-programmable gate arrays ("FPGAs") in future large DAQ systems. The DAQ system pipeline for the 864k channels of Si tracker in the GLAST LAT consists of five tiers of hardware buffers which ultimately feed into the main memory of the (two-active-node) level-3 trigger processor farm. The data formats and buffer volumes of these tiers are briefly described, as well as the flow control employed between successive tiers. Lessons learned regarding data formats, buffer volumes, and flow control/data discard policy are discussed. The continued development of platform FPGAs containing large amounts of configurable logic fabric, embedded PowerPC hard processor cores, digital signal processing components, large volumes of on-chip buffer memory, and multi-gigabit serial I/O capability permits DAQ system designers to vastly increase the amount of data preprocessing that can be performed in parallel within the DAQ pipeline for detector systems in large experiments. The capabilities of some currently available FPGA families are reviewed, along with the prospects for next-generation families of announced, but not yet available, platform FPGAs. Some experience with an actual implementation is presented, and reconciliation between advertised and achievable specifications is attempted. The prospects for applying these components to space-borne Si tracker detectors are briefly discussed.

In vivo contribution of nestin- and GLAST-lineage cells to adult hippocampal neurogenesis

PubMed Central

DeCarolis, Nathan A.; Mechanic, Maxwell; Petrik, David; Carlton, Adam; Ables, Jessica L.; Malhotra, Shveta; Bachoo, Robert; Götz, Magdalena; Lagace, Diane C.; Eisch, Amelia J.

2013-01-01

Radial glia-like cells (RGCs) are the hypothesized source of adult hippocampal neurogenesis. However, the current model of hippocampal neurogenesis does not fully incorporate the in vivo heterogeneity of RGCs. In order to better understand the contribution of different RGC subtypes to adult hippocampal neurogenesis, we employed widely-used transgenic lines (Nestin-CreERT2 and GLAST∷CreERT2 mice) to explore how RGCs contribute to neurogenesis under basal conditions and after stimulation and depletion of neural progenitor cells. We first used these inducible fate-tracking transgenic lines to define the similarities and differences in the contribution of nestin- and GLAST-lineage cells to basal long-term hippocampal neurogenesis. We then explored the ability of nestin- and GLAST-lineage RGCs to contribute to neurogenesis, after experimental manipulations that either ablate neurogenesis (i.c.v. application of the anti-mitotic AraC, cytosine-β-D-arabinofuranoside) or stimulate neurogenesis (wheel running). Interestingly, in both ablation and stimulation experiments, labeled RGCs in GLAST∷CreERT2 mice appear to contribute to neurogenesis, whereas RGCs in Nestin-CreERT2 mice do not. Finally, using NestinGFP reporter mice, we expanded on previous research by showing that not all RGCs in the adult dentate gyrus subgranular zone express nestin, and therefore RGCs are antigenically heterogeneous. These findings are important for the field, as they allow appropriately conservative interpretation of existing and future data that emerge from these inducible transgenic lines. These findings also raise important questions about the differences between transgenic driver lines, the heterogeneity of RGCs, and the potential differences in progenitor cell behavior between transgenic lines. As these findings highlight the possible differences in the contribution of nestin and GLAST lineage cells to long-term neurogenesis in vivo, they indicate that the current models of hippocampal neurogenesis should be modified to include RGC lineage heterogeneity. PMID:23554226

Gamma-ray Albedo of the Moon

DOE Office of Scientific and Technical Information (OSTI.GOV)

Moskalenko, Igor V.; Porter, Troy A.

2007-06-14

We use the GEANT4 Monte Carlo framework to calculate the gamma-ray albedo of the Moon due to interactions of cosmic ray (CR) nuclei with moon rock. Our calculation of the albedo spectrum agrees with the EGRET data. We show that the spectrum of gamma-rays from the Moon is very steep with an effective cutoff around 3 GeV (600 MeV for the inner part of the Moon disc). Since it is the only (almost) black spot in the gamma-ray sky, it provides a unique opportunity for calibration of gamma-ray telescopes, such as the forthcoming Gamma Ray Large Area Space Telescope (GLAST).more » The albedo flux depends on the incident CR spectrum which changes over the solar cycle. Therefore, it is possible to monitor the CR spectrum using the albedo gamma-ray flux. Simultaneous measurements of CR proton and helium spectra by the Payload for Antimatter Matter Exploration and Light-nuclei Astrophysics (PAMELA), and observations of the albedo -rays by the GLAST Large Area Telescope (LAT), can be used to test the model predictions and will enable the GLAST LAT to monitor the CR spectrum near the Earth beyond the lifetime of PAMELA.« less

Future Gamma-Ray Observations of Pulsars and their Environments

NASA Technical Reports Server (NTRS)

Thompson, David J.

2006-01-01

Pulsars and pulsar wind nebulae seen at gamma-ray energies offer insight into particle acceleration to very high energies under extreme conditions. Pulsed emission provides information about the geometry and interaction processes in the magnetospheres of these rotating neutron stars, while the pulsar wind nebulae yield information about high-energy particles interacting with their surroundings. During the next decade, a number of new and expanded gamma-ray facilities will become available for pulsar studies, including Astro-rivelatore Gamma a Immagini LEggero (AGILE) and Gamma-ray Large Area Space Telescope (GLAST) in space and a number of higher-energy ground-based systems. This review describes the capabilities of such observatories to answer some of the open questions about the highest-energy processes involving neutron stars.

Increased Glutamate Receptor and Transporter Expression in the Cerebral Cortex and Striatum of Gcdh -/- Mice: Possible Implications for the Neuropathology of Glutaric Acidemia Type I

PubMed Central

Lagranha, Valeska Lizzi; Matte, Ursula; de Carvalho, Talita Giacomet; Seminotti, Bianca; Pereira, Carolina Coffi; Koeller, David M.; Woontner, Michael; Goodman, Stephen I.; de Souza, Diogo Onofre Gomes; Wajner, Moacir

2014-01-01

We determined mRNA expression of the ionotropic glutamate receptors NMDA (NR1, NR2A and NR2B subunits), AMPA (GluR2 subunit) and kainate (GluR6 subunit), as well as of the glutamate transporters GLAST and GLT1 in cerebral cortex and striatum of wild type (WT) and glutaryl-CoA dehydrogenase deficient (Gchh -/-) mice aged 7, 30 and 60 days. The protein expression levels of some of these membrane proteins were also measured. Overexpression of NR2A and NR2B in striatum and of GluR2 and GluR6 in cerebral cortex was observed in 7-day-old Gcdh -/-. There was also an increase of mRNA expression of all NMDA subunits in cerebral cortex and of NR2A and NR2B in striatum of 30-day-old Gcdh -/- mice. At 60 days of life, all ionotropic receptors were overexpressed in cerebral cortex and striatum of Gcdh -/- mice. Higher expression of GLAST and GLT1 transporters was also verified in cerebral cortex and striatum of Gcdh -/- mice aged 30 and 60 days, whereas at 7 days of life GLAST was overexpressed only in striatum from this mutant mice. Furthermore, high lysine intake induced mRNA overexpression of NR2A, NR2B and GLAST transcripts in striatum, as well as of GluR2 and GluR6 in both striatum and cerebral cortex of Gcdh -/- mice. Finally, we found that the protein expression of NR2A, NR2B, GLT1 and GLAST were significantly greater in cerebral cortex of Gcdh -/- mice, whereas NR2B and GLT1 was similarly enhanced in striatum, implying that these transcripts were translated into their products. These results provide evidence that glutamate receptor and transporter expression is higher in Gcdh -/- mice and that these alterations may be involved in the pathophysiology of GA I and possibly explain, at least in part, the vulnerability of striatum and cerebral cortex to injury in patients affected by GA I. PMID:24594605

Increased glutamate receptor and transporter expression in the cerebral cortex and striatum of gcdh-/- mice: possible implications for the neuropathology of glutaric acidemia type I.

PubMed

Lagranha, Valeska Lizzi; Matte, Ursula; de Carvalho, Talita Giacomet; Seminotti, Bianca; Pereira, Carolina Coffi; Koeller, David M; Woontner, Michael; Goodman, Stephen I; de Souza, Diogo Onofre Gomes; Wajner, Moacir

2014-01-01

We determined mRNA expression of the ionotropic glutamate receptors NMDA (NR1, NR2A and NR2B subunits), AMPA (GluR2 subunit) and kainate (GluR6 subunit), as well as of the glutamate transporters GLAST and GLT1 in cerebral cortex and striatum of wild type (WT) and glutaryl-CoA dehydrogenase deficient (Gchh-/-) mice aged 7, 30 and 60 days. The protein expression levels of some of these membrane proteins were also measured. Overexpression of NR2A and NR2B in striatum and of GluR2 and GluR6 in cerebral cortex was observed in 7-day-old Gcdh-/-. There was also an increase of mRNA expression of all NMDA subunits in cerebral cortex and of NR2A and NR2B in striatum of 30-day-old Gcdh-/- mice. At 60 days of life, all ionotropic receptors were overexpressed in cerebral cortex and striatum of Gcdh-/- mice. Higher expression of GLAST and GLT1 transporters was also verified in cerebral cortex and striatum of Gcdh-/- mice aged 30 and 60 days, whereas at 7 days of life GLAST was overexpressed only in striatum from this mutant mice. Furthermore, high lysine intake induced mRNA overexpression of NR2A, NR2B and GLAST transcripts in striatum, as well as of GluR2 and GluR6 in both striatum and cerebral cortex of Gcdh-/- mice. Finally, we found that the protein expression of NR2A, NR2B, GLT1 and GLAST were significantly greater in cerebral cortex of Gcdh-/- mice, whereas NR2B and GLT1 was similarly enhanced in striatum, implying that these transcripts were translated into their products. These results provide evidence that glutamate receptor and transporter expression is higher in Gcdh-/- mice and that these alterations may be involved in the pathophysiology of GA I and possibly explain, at least in part, the vulnerability of striatum and cerebral cortex to injury in patients affected by GA I.

Targeting β-Catenin in GLAST-Expressing Cells: Impact on Anxiety and Depression-Related Behavior and Hippocampal Proliferation.

PubMed

Vidal, Rebeca; Garro-Martínez, Emilio; Díaz, Álvaro; Castro, Elena; Florensa-Zanuy, Eva; Taketo, Makoto M; Pazos, Ángel; Pilar-Cuéllar, Fuencisla

2018-05-08

β-catenin (key mediator in the Wnt signaling pathway) contributes to the pathophysiology of mood disorders, associated to neurogenesis and neuroplasticity. Decreased β-catenin protein levels have been observed in the hippocampus and prefrontal cortex of depressed subjects. Additionally, the antidepressants exert, at least in part, their neurogenic effects by increasing β-catenin levels in the subgranular zone of the hippocampus. To further understand the role of β-catenin in depression and anxiety, we generated two conditional transgenic mice in which β-catenin was either inactivated or stabilized in cells expressing CreERT under the control of the astrocyte-specific glutamate transporter (GLAST) promoter inducible by tamoxifen, which presents high expression levels on the subgranular zone of the hippocampus. Here, we show that β-catenin inactivation in GLAST-expressing cells enhanced anxious/depressive-like responses. These behavioral changes were associated with impaired hippocampal proliferation and markers of immature neurons as doublecortin. On the other hand, β-catenin stabilization induced an anxiolytic-like effect in the novelty suppressed feeding test and tended to ameliorate depressive-related behaviors. In these mice, the control over the Wnt/β-catenin pathway seems to be tighter as evidenced by the lack of changes in some proliferation markers. Moreover, animals with stabilized β-catenin showed resilience to some anxious/depressive manifestations when subjected to the corticosterone model of depression. Our findings demonstrate that β-catenin present in GLAST-expressing cells plays a critical role in the development of anxious/depressive-like behaviors and resilience, which parallels its regulatory function on hippocampal proliferation. Further studies need to be done to clarify the importance of these changes in other brain areas also implicated in the neurobiology of anxiety and depressive disorders.

KSC-08pd0613

NASA Image and Video Library

2008-03-04

KENNEDY SPACE CENTER, FLA. -- The shipping container holding NASA's Gamma-Ray Large Area Space Telescope, or GLAST, is moved into the Astrotech payload processing facility near the Kennedy Space Center to begin prelaunch activities. The GLAST will launch aboard a Delta II rocket May 16 from Launch Pad 17-B on Cape Canaveral Air Force Station. A powerful space observatory, the GLAST will explore the most extreme environments in the universe, and answer questions about supermassive black hole systems, pulsars and the origin of cosmic rays. It also will study the mystery of powerful explosions known as gamma-ray bursts. Photo credit: NASA/Kim Shiflett

KSC-08pd0610

NASA Image and Video Library

2008-03-04

KENNEDY SPACE CENTER, FLA. -- NASA's Gamma-Ray Large Area Space Telescope, or GLAST, arrives at Kennedy Space Center in a shipping container aboard a truck to begin final preparations for launch. The GLAST will launch aboard a Delta II rocket May 16 from Launch Pad 17-B on Cape Canaveral Air Force Station. A powerful space observatory, the GLAST will explore the most extreme environments in the universe, and answer questions about supermassive black hole systems, pulsars and the origin of cosmic rays. It also will study the mystery of powerful explosions known as gamma-ray bursts. Photo credit: NASA/Kim Shiflett

KSC-08pd0614

NASA Image and Video Library

2008-03-04

KENNEDY SPACE CENTER, FLA. -- In the Astrotech payload processing facility near the Kennedy Space Center, workers maneuver the shipping container holding NASA's Gamma-Ray Large Area Space Telescope, or GLAST, into place. The GLAST will launch aboard a Delta II rocket May 16 from Launch Pad 17-B on Cape Canaveral Air Force Station. A powerful space observatory, the GLAST will explore the most extreme environments in the universe, and answer questions about supermassive black hole systems, pulsars and the origin of cosmic rays. It also will study the mystery of powerful explosions known as gamma-ray bursts. Photo credit: NASA/Kim Shiflett

Testing Special Relativity at High Energies with Astrophysical Sources

NASA Technical Reports Server (NTRS)

Stecker, F. W.

2007-01-01

Since the group of Lorentz boosts is unbounded, there is a question as to whether Lorentz invariance (LI) holds to infinitely short distances. However, special and general relativity may break down at the Planck scale. Various quantum gravity scenarios such as loop quantum gravity, as well as some forms of string theory and extra dimension models may imply Lorentz violation (LV) at ultrahigh energies. The Gamma-Ray Large Area Space Telescope (GLAST), to be launched in mid-December, will measure the spectra of distant extragalactic sources of high energy gamma-rays, particularly active galactic nuclei and gamma-ray bursts. GLAST can look for energy-dependent gamma-ray propagation effects from such sources as a signal of Lorentz invariance violation. These sources may also exhibit the high energy cutoffs predicted to be the result of intergalactic annihilation interactions with low energy photons having a flux level as determined by various astronomical observations. With LV the threshold for such interactions can be significantly raised, changing the predicted absorption turnover in the observed spectrum of the sources. Stecker and Glashow have shown that the existence such absorption features in the spectra of extragalactic sources puts constraints on LV. Such constraints have important implications for some quantum gravity and large extra dimension models. Future spaceborne detectors dedicated to measuring gamma-ray polarization can look for birefringence effects as a possible signal of loop quantum gravity. A very small LV may also result in the modification or elimination of the GZK effect, thus modifying the spectrum of ultrahigh energy cosmic rays. This possibility can be explored with ground-based arrays such as Auger or with a space based detector system such as the proposed OWL satellite mission.

Detecting the Attenuation of Blazar Gamma-ray Emission by Extragalactic Background Light with GLAST

NASA Technical Reports Server (NTRS)

Chen, Andrew; Ritz, Steven

1999-01-01

Gamma rays with energy above 10 GeV interact with optical-UV photons resulting in pair production. Therefore, a large sample of high redshift sources of these gamma rays can be used to probe the extragalactic background starlight (EBL) by examining the redshift dependence of the attenuation of the flux above 10 GeV. GLAST, the next generation high-energy gamma-ray telescope, will for the first time have the unique capability to detect thousands of gamma-ray blazars up to redshifts of at least z = 4, with enough angular resolution to allow identification of a large fraction of their optical counterparts. By combining recent determinations of the gamma-ray blazar luminosity function, recent calculations of the high energy gamma-ray opacity due to EBL absorption, and the expected GLAST instrument performance to produce simulated samples of blazars that GLAST would detect, including their redshifts and fluxes, we demonstrate that these blazars have the potential to be a highly effective probe of the EBL.

GlastCam: A Telemetry-Driven Spacecraft Visualization Tool

NASA Technical Reports Server (NTRS)

Stoneking, Eric T.; Tsai, Dean

2009-01-01

Developed for the GLAST project, which is now the Fermi Gamma-ray Space Telescope, GlastCam software ingests telemetry from the Integrated Test and Operations System (ITOS) and generates four graphical displays of geometric properties in real time, allowing visual assessment of the attitude, configuration, position, and various cross-checks. Four windows are displayed: a "cam" window shows a 3D view of the satellite; a second window shows the standard position plot of the satellite on a Mercator map of the Earth; a third window displays star tracker fields of view, showing which stars are visible from the spacecraft in order to verify star tracking; and the fourth window depicts

KSC-08pd0653

NASA Image and Video Library

2008-03-05

KENNEDY SPACE CENTER, FLA. -- In the Astrotech payload processing facility, General Dynamics technicians secure NASA's Gamma-Ray Large Area Space Telescope, or GLAST, onto a work stand. There GLAST will undergo a complete checkout of the scientific instruments aboard. The telescope will launch aboard a Delta II rocket May 16 from Launch Pad 17-B on Cape Canaveral Air Force Station. A powerful space observatory, the GLAST will explore the most extreme environments in the universe, and answer questions about supermassive black hole systems, pulsars and the origin of cosmic rays. It also will study the mystery of powerful explosions known as gamma-ray bursts. Photo credit: NASA/Kim Shiflett

KSC-08pd0615

NASA Image and Video Library

2008-03-04

KENNEDY SPACE CENTER, FLA. -- In the Astrotech payload processing facility near the Kennedy Space Center, the shipping container covering NASA's Gamma-Ray Large Area Space Telescope, or GLAST, is lifted. Workers will prepare for a complete checkout of the telescope's scientific instruments. The GLAST will launch aboard a Delta II rocket May 16 from Launch Pad 17-B on Cape Canaveral Air Force Station. A powerful space observatory, the GLAST will explore the most extreme environments in the universe, and answer questions about supermassive black hole systems, pulsars and the origin of cosmic rays. It also will study the mystery of powerful explosions known as gamma-ray bursts. Photo credit: NASA/Kim Shiflett

KSC-08pd0611

NASA Image and Video Library

2008-03-04

KENNEDY SPACE CENTER, FLA. -- The shipping container holding NASA's Gamma-Ray Large Area Space Telescope, or GLAST, is removed from the truck at the Astrotech payload processing facility near the Kennedy Space Center to begin prelaunch activities. The GLAST will launch aboard a Delta II rocket May 16 from Launch Pad 17-B on Cape Canaveral Air Force Station. A powerful space observatory, the GLAST will explore the most extreme environments in the universe, and answer questions about supermassive black hole systems, pulsars and the origin of cosmic rays. It also will study the mystery of powerful explosions known as gamma-ray bursts. Photo credit: NASA/Kim Shiflett

KSC-08pd0612

NASA Image and Video Library

2008-03-04

KENNEDY SPACE CENTER, FLA. -- The shipping container holding NASA's Gamma-Ray Large Area Space Telescope, or GLAST, is removed from the truck at the Astrotech payload processing facility near the Kennedy Space Center to begin prelaunch activities. The GLAST will launch aboard a Delta II rocket May 16 from Launch Pad 17-B on Cape Canaveral Air Force Station. A powerful space observatory, the GLAST will explore the most extreme environments in the universe, and answer questions about supermassive black hole systems, pulsars and the origin of cosmic rays. It also will study the mystery of powerful explosions known as gamma-ray bursts. Photo credit: NASA/Kim Shiflett

KSC-08pd0617

NASA Image and Video Library

2008-03-04

KENNEDY SPACE CENTER, FLA. -- In the Astrotech payload processing facility near the Kennedy Space Center, workers check NASA's Gamma-Ray Large Area Space Telescope, or GLAST, after removal of the shipping container. The workers will prepare for a complete checkout of the telescope's scientific instruments. The GLAST will launch aboard a Delta II rocket May 16 from Launch Pad 17-B on Cape Canaveral Air Force Station. A powerful space observatory, the GLAST will explore the most extreme environments in the universe, and answer questions about supermassive black hole systems, pulsars and the origin of cosmic rays. It also will study the mystery of powerful explosions known as gamma-ray bursts. Photo credit: NASA/Kim Shiflett

KSC-08pd0654

NASA Image and Video Library

2008-03-05

KENNEDY SPACE CENTER, FLA. -- In the Astrotech payload processing facility, General Dynamics technicians secure NASA's Gamma-Ray Large Area Space Telescope, or GLAST, on a work stand as the overhead crane is lifted away. GLAST will undergo a complete checkout of the scientific instruments aboard. The telescope will launch aboard a Delta II rocket May 16 from Launch Pad 17-B on Cape Canaveral Air Force Station. A powerful space observatory, the GLAST will explore the most extreme environments in the universe, and answer questions about supermassive black hole systems, pulsars and the origin of cosmic rays. It also will study the mystery of powerful explosions known as gamma-ray bursts. Photo credit: NASA/Kim Shiflett

KSC-08pd0649

NASA Image and Video Library

2008-03-05

KENNEDY SPACE CENTER, FLA. -- In the Astrotech payload processing facility, General Dynamics technicians keep watch as NASA's Gamma-Ray Large Area Space Telescope, or GLAST, is lifted and begins moving toward the work stand in the foreground. There GLAST will undergo a complete checkout of the scientific instruments aboard. The telescope will launch aboard a Delta II rocket May 16 from Launch Pad 17-B on Cape Canaveral Air Force Station. A powerful space observatory, the GLAST will explore the most extreme environments in the universe, and answer questions about supermassive black hole systems, pulsars and the origin of cosmic rays. It also will study the mystery of powerful explosions known as gamma-ray bursts. Photo credit: NASA/Kim Shiflett

KSC-08pd1603

NASA Image and Video Library

2008-06-09

CAPE CANAVERAL, Fla. -- At NASA's Kennedy Space Center, key personnel brief the media on NASA's Gamma-Ray Large Area Space Telescope, or GLAST, launch scheduled for June 11. From left are Dr. Jon Morse, director of NASA's Astrophysics Division; Omar Baez, NASA launch director/launch manager at Kennedy; Kris Walsh, director of the Delta NASA and Commercial Programs with United Launch Alliance; Kevin Grady, GLAST project manager at NASA's Goddard Space Flight Center; Dr. Steven Ritz, GLAST project scientist/astrophysicist at Goddard; and Joel Tumbiolo, the U.S. Air Force Delta II launch weather officer with the 45th Weather Squadron at Cape Canaveral Air Force Station. GLAST is a powerful space observatory that will explore the Universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. Photo credit: NASA/Kim Shiflett

KSC-08pd1604

NASA Image and Video Library

2008-06-09

CAPE CANAVERAL, Fla. -- At left, Public Information Officer George Diller moderates a media briefing on NASA's Gamma-Ray Large Area Space Telescope, or GLAST, launch scheduled for June 11. On the panel next to Diller are Dr. Jon Morse, director of NASA's Astrophysics Division; Omar Baez, NASA launch director/launch manager at Kennedy; Kris Walsh, director of the Delta NASA and Commercial Programs with United Launch Alliance; Kevin Grady, GLAST project manager at NASA's Goddard Space Flight Center; Dr. Steven Ritz, GLAST project scientist/astrophysicist at Goddard; and Joel Tumbiolo, the U.S. Air Force Delta II launch weather officer with the 45th Weather Squadron at Cape Canaveral Air Force Station. GLAST is a powerful space observatory that will explore the Universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. Photo credit: NASA/Kim Shiflett

Gamma-Ray Pulsar Candidates for GLAST

NASA Technical Reports Server (NTRS)

Thompson, D. J.

2008-01-01

The Gamma-ray Large Area Space Telescope (GLAST) will be launched this year, and its Large Area Telescope (LAT) is expected to discover scores to hundreds of gamma-ray pulsars. This poster discusses which of the over 1700 known pulsars, mostly visible only at radio frequencies, are likely to emit greater than 100 MeV gamma rays with intensities detectable by the LAT. The main figure of merit used to select gamma-ray pulsar candidates is sqrt(E-dot)/d2, where E-dot is the energy loss due to rotational spin-down, and d is the distance to the pulsar. The figure of merit incorporates spin-down flux at earth (proportional to E-dot/d2) times efficiency, assumed proportional to l/sqrt(E-dot). A few individual objects are cited to illustrate the issues. Since large E-dot pulsars also tend to have large timing noise and occasional glitches, their ephemerides can become inaccurate in weeks to months. To detect and study the gamma-ray emission the photons must be accurately tagged with the pulse phase. With hours to days between gamma-ray photon arrival times from a pulsar and months to years of LAT exposure needed for good detections, GLAST will rely on radio and X-ray timing measurements throughout the continuous gamma-ray observations. The poster will describe efforts to coordinate pulsar timing of the candidate gamma-ray pulsars.

Gamma-Ray Pulsar Candidates for GLAST

NASA Technical Reports Server (NTRS)

Thompson, David J.; Smith, D. A.; Dumora, D.; Guillemot, L.; Parent, D.; Reposeur, T.; Grove, E.; Romani, R. W.; Thorsett, S. E.

2007-01-01

The Gamma-ray Large Area Space Telescope (GLAST) will be launched less than a year from now, and its Large Area Telescope (LAT) is expected to discover scores to hundreds of gamma-ray pulsars. This poster discusses which of the over 1700 known pulsars, mostly visible only at radio Erequencies, are likely to emit greater than l00 MeV gamma rays with intensities detectable by the LAT. The main figure of merit used to select gamma-ray pulsar candidates is sqrt(E-dot)/d^2, where E-dot is the energy loss due to rotational spindown, and d is the distance to the pulsar. The figure of merit incorporates spin-down flux at earth (proportional to E-dot/d^2) times efficiency, assumed proportional to 1/sqrt(E-dot). A few individual objects are cited to illustrate the issues. Since large E-dot pulsars also tend to have large timing noise and occasional glitches, their ephemerides can become inaccurate in weeks to months. To detect and study the gamma-ray emission the photons must be accurately tagged with the pulse phase. With hours to days between gamma-ray photon arrival times from a pulsar and months to years of LAT exposure needed for good detections, GLAST will need timing measurements throughout the continuous gamma-ray observations. The poster will describe efforts to coordinate pulsar timing of the candidate gamma-ray pulsars.

GLAST: Exploring Nature's Highest Energy Processes with the Gamma-ray Large Area Space Telescope

NASA Technical Reports Server (NTRS)

Digel, Seth; Myers, J. D.; White, Nicholas E. (Technical Monitor)

2001-01-01

The Gamma-ray Large Area Space Telescope (GLAST) is an international and multi-agency space mission that will study the cosmos in the energy range 10 keV-300 GeV. Several successful exploratory missions in gamma-ray astronomy led to the Energetic Gamma Ray Experiment Telescope (EGRET) instrument on the Compton Gamma Ray Observatory (CGRO). Launched in 1991, EGRET made the first complete survey of the sky in the 30 MeV-10 GeV range. EGRET showed the high-energy gamma-ray sky to be surprisingly dynamic and diverse, with sources ranging from the sun and moon to massive black holes at large redshifts. Most of the gamma-ray sources detected by EGRET remain unidentified. In light of the discoveries with EGRET, the great potential of the next generation gamma-ray telescope can be appreciated. GLAST will have an imaging gamma-ray telescope vastly more capable than instruments flown previously, as well as a secondary instrument to augment the study of gamma-ray bursts. The main instrument, the Large Area Telescope (LAT), will have superior area, angular resolution, field of view, and deadtime that together will provide a factor of 30 or more advance in sensitivity, as well as provide capability for study of transient phenomena. The GLAST Burst Monitor (GBM) will have a field of view several times larger than the LAT and will provide spectral coverage of gamma-ray bursts that extends from the lower limit of the LAT down to 10 keV. The basic parameters of the GBM are compared to those of the Burst and Transient Source Experiment (BATSE) instrument on CGRO in Table 1-2. With the LAT and GBM, GLAST will be a flexible observatory for investigating the great range of astrophysical phenomena best studied in high-energy gamma rays. NASA plans to launch GLAST in late 2005.

Peri-adolescent drinking of ethanol and/or nicotine modulates astroglial glutamate transporters and metabotropic glutamate receptor-1 in female alcohol-preferring rats.

PubMed

Alasmari, Fawaz; Bell, Richard L; Rao, P S S; Hammad, Alaa M; Sari, Youssef

2018-07-01

Impairment in glutamate neurotransmission mediates the development of dependence upon nicotine (NIC) and ethanol (EtOH). Previous work indicates that continuous access to EtOH or phasic exposure to NIC reduces expression of the glutamate transporter-1 (GLT-1) and cystine/glutamate antiporter (xCT) but not the glutamate/aspartate transporter (GLAST). Additionally, metabotropic glutamate receptors (mGluRs) expression was affected following exposure to EtOH or NIC. However, little is known about the effects of EtOH and NIC co-consumption on GLT-1, xCT, GLAST, and mGluR1 expression. In this study, peri-adolescent female alcohol preferring (P) rats were given binge-like access to water, sucrose (SUC), SUC-NIC, EtOH, or EtOH-NIC for four weeks. The present study determined the effects of these reinforcers on GLT-1, xCT, GLAST, and mGluR1 expression in the nucleus accumbens (NAc), hippocampus (HIP) and prefrontal cortex (PFC). GLT-1 and xCT expression were decreased in the NAc following both SUC-NIC and EtOH-NIC. In addition, only xCT expression was downregulated in the HIP in both of these latter groups. Also, glutathione peroxidase (GPx) activity in the HIP was reduced following SUC, SUC-NIC, EtOH, and EtOH-NIC consumption. Similar to previous work, GLAST expression was not altered in any brain region by any of the reinforcers. However, mGluR1 expression was increased in the NAc in the SUC-NIC, EtOH, and EtOH-NIC groups. These results indicate that peri-adolescent binge-like drinking of EtOH or SUC with or without NIC may exert differential effects on astroglial glutamate transporters and receptors. Our data further parallel some of the previous findings observed in adult rats. Copyright © 2018. Published by Elsevier Inc.

Fermi (Formerly GLAST) at Six Months

NASA Technical Reports Server (NTRS)

Ritz, Steven M.

2009-01-01

The Fermi Gamma-ray Space Telescope, formerly called GLAST, is a mission to measure the cosmic gamma-ray flux in the energy range 20 MeV to more than 300 GeV, with supporting measurements for gamma-ray bursts from 8 keV to 30 MeV. In addition to breakthrough capabilities in energy coverage and localization, the very large field of view enables observations of 20% of the sky at any instant, and the entire sky on a timescale of a few hours. With its recent launch on 11 June 2008, Fermi now opens a new and important window on a wide variety of phenomena, including pulsars, black holes and active galactic nuclei, gamma-ray bursts, the origin of cosmic rays and supernova remnants, and searches for hypothetical new phenomena such as supersymmetric dark matter annihilations. In addition to early results and the science opportunities, this talk includes a description of the instruments and the mission status and plans.

Fermi (nee GLAST) at Six Months

NASA Technical Reports Server (NTRS)

Ritz, Steve

2009-01-01

The Fermi Gamma-ray Space Telescope, formerly called GLAST, is a mission to measure the cosmic gamma-ray flux in the energy range 20 MeV to >300 GeV, with supporting measurements for gamma-ray bursts from 8 keV to 30 MeV. In addition to breakthrough capabilities in energy coverage and localization, the very large field of view enables observations of 20% of the sky at any instant, and the entire sky on a timescale of a few hours. With its recent launch on 11 June 2008, Fermi now opens a new and important window on a wide variety of phenomena, including pulsars, black holes and active galactic nuclei, gamma-ray bursts, the origin of cosmic rays and supernova remnants, and searches for hypothetical new phenomena such as supersymmetric dark matter annihilations. In addition to early results and the science opportunities, this talk includes a description of the instruments and the mission status and plans.

Studies of EGRET sources with a novel image restoration technique

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tajima, Hiroyasu; Cohen-Tanugi, Johann; Kamae, Tuneyoshi

2007-07-12

We have developed an image restoration technique based on the Richardson-Lucy algorithm optimized for GLAST-LAT image analysis. Our algorithm is original since it utilizes the PSF (point spread function) that is calculated for each event. This is critical for EGRET and GLAST-LAT image analysis since the PSF depends on the energy and angle of incident gamma-rays and varies by more than one order of magnitude. EGRET and GLAST-LAT image analysis also faces Poisson noise due to low photon statistics. Our technique incorporates wavelet filtering to minimize noise effects. We present studies of EGRET sources using this novel image restoration techniquemore » for possible identification of extended gamma-ray sources.« less

KSC-08pd1419

NASA Image and Video Library

2008-05-17

CAPE CANAVERAL, Fla. -- At pad 17-B at Cape Canaveral Air Force Station, workers prepare to move the GLAST spacecraft into the mobile service tower. In the tower, GLAST will be mated with the Delta II second stage. GLAST is a powerful space observatory that will explore the Universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. The launch date is targeted no earlier than June 3. Photo credit: NASA/Kim Shiflett

KSC-08pd1414

NASA Image and Video Library

2008-05-17

CAPE CANAVERAL, Fla. -- At pad 17-B at Cape Canaveral Air Force Station, workers secure the lines of the hoist that will lift the GLAST spacecraft into the mobile service tower. In the tower, GLAST will be mated with the Delta II second stage. GLAST is a powerful space observatory that will explore the Universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. The launch date is targeted no earlier than June 3. Photo credit: NASA/Kim Shiflett

KSC-08pd0433

NASA Image and Video Library

2008-02-19

KENNEDY SPACE CENTER, FLA. -- At Cape Canaveral Air Force Station, the Delta II second stage for GLAST has arrived at Hangar M and is prepared for weighing. The Delta rocket will be used to launch the Gamma-Ray Large Area Space Telescope, or GLAST, May 16 from Launch Pad 17-B on CCAFS. The GLAST is a powerful space observatory that will explore the Universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. Photo credit: NASA/Kim Shiflett

KSC-08pd1423

NASA Image and Video Library

2008-05-17

CAPE CANAVERAL, Fla. -- At pad 17-B at Cape Canaveral Air Force Station, workers begin lowering the GLAST spacecraft into the opening above the Delta II second stage in the mobile service tower. GLAST will be mated with the Delta II second stage. GLAST is a powerful space observatory that will explore the Universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. The launch date is targeted no earlier than June 3. Photo credit: NASA/Kim Shiflett

KSC-08pd1413

NASA Image and Video Library

2008-05-17

CAPE CANAVERAL, Fla. -- At pad 17-B at Cape Canaveral Air Force Station, workers secure the lines of the hoist that will lift the GLAST spacecraft into the mobile service tower. In the tower, GLAST will be mated with the Delta II second stage. GLAST is a powerful space observatory that will explore the Universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. The launch date is targeted no earlier than June 3. Photo credit: NASA/Kim Shiflett

KSC-08pd1422

NASA Image and Video Library

2008-05-17

CAPE CANAVERAL, Fla. -- At pad 17-B at Cape Canaveral Air Force Station, workers help maneuver the GLAST spacecraft toward the opening above the Delta II second stage in the mobile service tower. GLAST will be mated with the Delta II second stage. GLAST is a powerful space observatory that will explore the Universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. The launch date is targeted no earlier than June 3. Photo credit: NASA/Kim Shiflett

KSC-08pd1425

NASA Image and Video Library

2008-05-17

CAPE CANAVERAL, Fla. -- At pad 17-B at Cape Canaveral Air Force Station, the GLAST spacecraft is lowered onto the Delta II second stage in the mobile service tower. GLAST will be mated with the Delta II second stage. GLAST is a powerful space observatory that will explore the Universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. The launch date is targeted no earlier than June 3. Photo credit: NASA/Kim Shiflett

KSC-08pd1421

NASA Image and Video Library

2008-05-17

CAPE CANAVERAL, Fla. -- At pad 17-B at Cape Canaveral Air Force Station, workers help maneuver the GLAST spacecraft into the mobile service tower. In the tower, GLAST will be mated with the Delta II second stage. GLAST is a powerful space observatory that will explore the Universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. The launch date is targeted no earlier than June 3. Photo credit: NASA/Kim Shiflett

KSC-08pd1418

NASA Image and Video Library

2008-05-17

CAPE CANAVERAL, Fla. -- At pad 17-B at Cape Canaveral Air Force Station, the GLAST spacecraft continues its rise toward the upper level of the mobile service tower. In the tower, GLAST will be mated with the Delta II second stage. GLAST is a powerful space observatory that will explore the Universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. The launch date is targeted no earlier than June 3. Photo credit: NASA/Kim Shiflett

KSC-08pd1135

NASA Image and Video Library

2008-05-03

CAPE CANAVERAL, Fla. -- At the Astrotech payload processing facility in Titusville, Fla., technicians stretch protective cover over NASA's Gamma-ray Large Area Space Telescope, or GLAST, spacecraft. GLAST is being prepared for its move to the Hazardous Processing Facility for fueling. The GLAST is a powerful space observatory that will explore the universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. A launch date is still to be determined. Photo credit: NASA/Mike Kerley

KSC-08pd1136

NASA Image and Video Library

2008-05-03

CAPE CANAVERAL, Fla. -- At the Astrotech payload processing facility in Titusville, Fla., technicians stretch protective cover over NASA's Gamma-ray Large Area Space Telescope, or GLAST, spacecraft. GLAST is being prepared for its move to the Hazardous Processing Facility for fueling. The GLAST is a powerful space observatory that will explore the universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. A launch date is still to be determined. Photo credit: NASA/Mike Kerley

KSC-08pd1134

NASA Image and Video Library

2008-05-03

CAPE CANAVERAL, Fla. -- At the Astrotech payload processing facility in Titusville, Fla., technicians begin placing a protective cover over NASA's Gamma-ray Large Area Space Telescope, or GLAST, spacecraft. GLAST is being prepared for its move to the Hazardous Processing Facility for fueling. The GLAST is a powerful space observatory that will explore the universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. A launch date is still to be determined. Photo credit: NASA/Mike Kerley

KSC-08pd1359

NASA Image and Video Library

2008-05-14

CAPE CANAVERAL, Fla. -- At the Astrotech payload processing facility, technicians lower NASA's Gamma-Ray Large Area Space Telescope, or GLAST, spacecraft toward the payload attach fitting. The fitting will eventually be used to mate GLAST to the Delta II launch vehicle. The GLAST is a powerful space observatory that will explore the Universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. A launch date still is to be determined. Photo credit: NASA/Jim Grossmann

KSC-08pd1358

NASA Image and Video Library

2008-05-14

CAPE CANAVERAL, Fla. -- At the Astrotech payload processing facility, technicians lower NASA's Gamma-Ray Large Area Space Telescope, or GLAST, spacecraft toward the payload attach fitting. The fitting will eventually be used to mate GLAST to the Delta II launch vehicle. The GLAST is a powerful space observatory that will explore the Universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. A launch date still is to be determined. Photo credit: NASA/Jim Grossmann

KSC-08pd1360

NASA Image and Video Library

2008-05-14

CAPE CANAVERAL, Fla. -- At the Astrotech payload processing facility, technicians check the placement of NASA's Gamma-Ray Large Area Space Telescope, or GLAST, spacecraft on the payload attach fitting. The fitting will eventually be used to mate GLAST to the Delta II launch vehicle. The GLAST is a powerful space observatory that will explore the Universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. A launch date still is to be determined. Photo credit: NASA/Jim Grossmann

KSC-08pd1352

NASA Image and Video Library

2008-05-14

CAPE CANAVERAL, Fla. -- At the Astrotech payload processing facility, NASA's Gamma-Ray Large Area Space Telescope, or GLAST, spacecraft is being prepared for a move to an payload attach fitting that will eventually be used to mate GLAST to the Delta II launch vehicle. The GLAST is a powerful space observatory that will explore the Universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. A launch date still is to be determined. Photo credit: NASA/Jim Grossmann

KSC-08pd1356

NASA Image and Video Library

2008-05-14

CAPE CANAVERAL, Fla. -- At the Astrotech payload processing facility, technicians prepare the payload attach fitting that will receive NASA's Gamma-Ray Large Area Space Telescope, or GLAST, spacecraft. The fitting will eventually be used to mate GLAST to the Delta II launch vehicle. The GLAST is a powerful space observatory that will explore the Universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. A launch date still is to be determined. Photo credit: NASA/Jim Grossmann

KSC-08pd1361

NASA Image and Video Library

2008-05-14

CAPE CANAVERAL, Fla. -- At the Astrotech payload processing facility, technicians check the attachment of NASA's Gamma-Ray Large Area Space Telescope, or GLAST, spacecraft on the payload attach fitting. The fitting will eventually be used to mate GLAST to the Delta II launch vehicle. The GLAST is a powerful space observatory that will explore the Universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. A launch date still is to be determined. Photo credit: NASA/Jim Grossmann

KSC-08pd1355

NASA Image and Video Library

2008-05-14

CAPE CANAVERAL, Fla. -- At the Astrotech payload processing facility, technicians prepare NASA's Gamma-Ray Large Area Space Telescope, or GLAST, spacecraft for its move to the payload attach fitting that will eventually be used to mate GLAST to the Delta II launch vehicle. The GLAST is a powerful space observatory that will explore the Universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. A launch date still is to be determined. Photo credit: NASA/Jim Grossmann

KSC-08pd0643

NASA Image and Video Library

2008-03-05

KENNEDY SPACE CENTER, FLA. -- A General Dynamics technician in the Astrotech payload processing facility releases a corner of the protective cover over NASA's Gamma-Ray Large Area Space Telescope, or GLAST, after its arrival. GLAST will be moved to a work stand in the facility for a complete checkout of the telescope's scientific instruments. The telescope will launch aboard a Delta II rocket May 16 from Launch Pad 17-B on Cape Canaveral Air Force Station. A powerful space observatory, the GLAST will explore the most extreme environments in the universe, and answer questions about supermassive black hole systems, pulsars and the origin of cosmic rays. It also will study the mystery of powerful explosions known as gamma-ray bursts. Photo credit: NASA/Kim Shiflett

Observing the Extragalactic Universe with a Square Kilometer Array

NASA Astrophysics Data System (ADS)

Blandford, R. D.

2001-12-01

The Square Kilometer Array, SKA, is being developed to provide broad, radio survey capability to cm wavelength, with a 1 degree field of view, 1 arcsec resolution and 100 times the VLA sensitivity. In extragalactic astronomy, it will observe unobscured, normal and active galaxies, star formation and mergers, large scale structure and gravitational lenses throughout the universe. It will contribute mightily to our emerging, empirical description of the birth and growth of galaxies of all type. It should also advance our understanding of the conditions that existed prior to galaxy formation at the end of the dark age and help delineate the dark matter skeleton that supports mature galaxies. It will map and monitor, in quite different modes, the same objects as Chandra, SIRTF, HST/ACS, GLAST, SDSS as well as future missions like NGST and Constellation-X. The proposed scientific capability of SKA will be summarized. In addition, the importance of refining its goals and design criteria in a dialog with organizations making complementary plans throughout the electromagnetic spectrum will be emphasized.

Glutamate transporter GLAST controls synaptic wrapping by Bergmann glia and ensures proper wiring of Purkinje cells

PubMed Central

Miyazaki, Taisuke; Yamasaki, Miwako; Hashimoto, Kouichi; Kohda, Kazuhisa; Yuzaki, Michisuke; Shimamoto, Keiko; Tanaka, Kohichi; Kano, Masanobu; Watanabe, Masahiko

2017-01-01

Astrocytes regulate synaptic transmission through controlling neurotransmitter concentrations around synapses. Little is known, however, about their roles in neural circuit development. Here we report that Bergmann glia (BG), specialized cerebellar astrocytes that thoroughly enwrap Purkinje cells (PCs), are essential for synaptic organization in PCs through the action of the l-glutamate/l-aspartate transporter (GLAST). In GLAST-knockout mice, dendritic innervation by the main ascending climbing fiber (CF) branch was significantly weakened, whereas the transverse branch, which is thin and nonsynaptogenic in control mice, was transformed into thick and synaptogenic branches. Both types of CF branches frequently produced aberrant wiring to proximal and distal dendrites, causing multiple CF–PC innervation. Our electrophysiological analysis revealed that slow and small CF-evoked excitatory postsynaptic currents (EPSCs) were recorded from almost all PCs in GLAST-knockout mice. These atypical CF-EPSCs were far more numerous and had significantly faster 10–90% rise time than those elicited by glutamate spillover under pharmacological blockade of glial glutamate transporters. Innervation by parallel fibers (PFs) was also affected. PF synapses were robustly increased in the entire dendritic trees, leading to impaired segregation of CF and PF territories. Furthermore, lamellate BG processes were retracted from PC dendrites and synapses, leading to the exposure of these neuronal elements to the extracellular milieus. These synaptic and glial phenotypes were reproduced in wild-type mice after functional blockade of glial glutamate transporters. These findings highlight that glutamate transporter function by GLAST on BG plays important roles in development and maintenance of proper synaptic wiring and wrapping in PCs. PMID:28655840

Future Facilities for Gamma-Ray Pulsar Studies

NASA Technical Reports Server (NTRS)

Thompson, D. J.

2003-01-01

Pulsars seen at gamma-ray energies offer insight into particle acceleration to very high energies, along with information about the geometry and interaction processes in the magnetospheres of these rotating neutron stars. During the next decade, a number of new gamma-ray facilities will become available for pulsar studies. This brief review describes the motivation for gamma-ray pulsar studies, the opportunities for such studies, and some specific discussion of the capabilities of the Gamma-ray Large Area Space Telescope (GLAST) Large Area Telescope (LAT) for pulsar measurements.

GLAST and Suzaku

NASA Technical Reports Server (NTRS)

Sambruna, Rita

2007-01-01

The upcoming years will see a formidable synergy of high-energy observatories for the study of extragalactic objects, especially AGN. In particular, the launch of GLAST will allow us coordinated monitoring of sources with Suzaku over a very large energy band, from medium X-rays to GeV energies. In this talk I will review the science issues that such a remarkable coverage will enable us to address.

Active Galaxies Educational Unit: An Educator's Guide with Activities in Science and Mathematics.

ERIC Educational Resources Information Center

National Aeronautics and Space Administration, Washington, DC.

As a part of its educational effort, the National Aeronautics and Space Administration (NASA) Education and Public Outreach group at Sonoma State University (SSU) has put together a series of activities based on the science of one of NASA's exciting space missions, the Gamma-ray Large Area Space Telescope (GLAST). GLAST is a NASA satellite planned…

Prospects for Pulsar Studies with the GLAST Large Area Telescope

NASA Technical Reports Server (NTRS)

Harding, Alice K.

2006-01-01

The Large Area Telescope (LAT) on the Gamma-ray Large Area Space Telescope (GLAST) will have unprecedented sensitivity and energy resolution for gamma-rays in the range of 30 MeV to 200 GeV. GLAST is therefore expected to provide major advances in the understanding of high-energy emission from rotation-powered pulsars. As the only presently known galactic GeV source class, pulsars will be one of the most important sources for study with GLAST. The main science goals of the LAT for pulsar studies include an increase in the number of detected radio-loud and radio-quiet gamma ray pulsars, including millisecond pulsars, giving much better statistics for elucidating population characteristics, measurement of the high-energy spectrum and the shape of spectral cutoffs and determining pulse profiles for a variety of pulsars of different age. Further, measurement of phase-resolved spectra and energy dependent pulse profiles of the brighter pulsars should allow detailed tests of magnetospheric particle acceleration and radiation mechanisms, by comparing data with theoretical models that have been developed. Additionally, the LAT will have the sensitivity to allow blind pulsation searches of nearly all unidentified EGRET sources, to possibly uncover more radio-quiet Geminga-like pulsars.

Intrinsic Astrocyte Heterogeneity Influences Tumor Growth in Glioma Mouse Models.

PubMed

Irvin, David M; McNeill, Robert S; Bash, Ryan E; Miller, C Ryan

2017-01-01

The influence of cellular origin on glioma pathogenesis remains elusive. We previously showed that mutations inactivating Rb and Pten and activating Kras transform astrocytes and induce tumorigenesis throughout the adult mouse brain. However, it remained unclear whether astrocyte subpopulations were susceptible to these mutations. We therefore used genetic lineage tracing and fate mapping in adult conditional, inducible genetically engineered mice to monitor transformation of glial fibrillary acidic protein (GFAP) and glutamate aspartate transporter (GLAST) astrocytes and immunofluorescence to monitor cellular composition of the tumor microenvironment over time. Because considerable regional heterogeneity exists among astrocytes, we also examined the influence of brain region on tumor growth. GFAP astrocyte transformation induced uniformly rapid, regionally independent tumor growth, but transformation of GLAST astrocytes induced slowly growing tumors with significant regional bias. Transformed GLAST astrocytes had reduced proliferative response in culture and in vivo and malignant progression was delayed in these tumors. Recruited glial cells, including proliferating astrocytes, oligodendrocyte progenitors and microglia, were the majority of GLAST, but not GFAP astrocyte-derived tumors and their abundance dynamically changed over time. These results suggest that intrinsic astrocyte heterogeneity, and perhaps regional brain microenvironment, significantly contributes to glioma pathogenesis. © 2016 International Society of Neuropathology.

Studying the High Energy Gamma Ray Sky with Gamma Ray Large Area Space Telescope (GLAST)

NASA Technical Reports Server (NTRS)

Kamae, T.; Ohsugi, T.; Thompson, D. J.; Watanabe, K.

1998-01-01

Building on the success of the Energetic Gamma Ray Experiment Telescope (EGRET) on the Compton Gamma Ray Observatory, the Gamma Ray Large Area Space Telescope (GLAST) will make a major step in the study of such subjects as blazars, gamma Ray bursts, the search for dark matter, supernova remnants, pulsars, diffuse radiation, and unidentified high energy sources. The instrument will be built on new and mature detector technologies such as silicon strip detectors, low-power low-noise LSI, and a multilevel data acquisition system. GLAST is in the research and development phase, and one full tower (of 25 total) is now being built in collaborating institutes. The prototype tower will be tested thoroughly at Stanford Linear Accelerator Center (SLAC) in the fall of 1999.

KSC-08pd0432

NASA Image and Video Library

2008-02-19

KENNEDY SPACE CENTER, FLA. -- At Cape Canaveral Air Force Station, the Delta II second stage for GLAST has arrived at Hangar M and is moved into place for weighing. The Delta rocket will be used to launch the Gamma-Ray Large Area Space Telescope, or GLAST, May 16 from Launch Pad 17-B on CCAFS. The GLAST is a powerful space observatory that will explore the Universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. Photo credit: NASA/Kim Shiflett

KSC-08pd1357

NASA Image and Video Library

2008-05-14

CAPE CANAVERAL, Fla. -- At the Astrotech payload processing facility, technicians begin lifting and moving NASA's Gamma-Ray Large Area Space Telescope, or GLAST, spacecraft for its move to a payload attach fitting that will eventually be used to mate GLAST to the Delta II launch vehicle. The GLAST is a powerful space observatory that will explore the Universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. A launch date still is to be determined. Photo credit: NASA/Jim Grossmann

KSC-08pd1353

NASA Image and Video Library

2008-05-14

CAPE CANAVERAL, Fla. -- At the Astrotech payload processing facility, NASA's Gamma-Ray Large Area Space Telescope, or GLAST, spacecraft is being prepared for a move to an payload attach fitting, in the foreground, that will eventually be used to mate GLAST to the Delta II launch vehicle. The GLAST is a powerful space observatory that will explore the Universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. A launch date still is to be determined. Photo credit: NASA/Jim Grossmann

Glutamate transporter-dependent mTOR phosphorylation in Müller glia cells

PubMed Central

María López-Colomé, Ana; Martínez-Lozada, Zila; Guillem, Alain M; López, Edith; Ortega, Arturo

2012-01-01

Glu (glutamate), the excitatory transmitter at the main signalling pathway in the retina, is critically involved in changes in the protein repertoire through the activation of signalling cascades, which regulate protein synthesis at transcriptional and translational levels. Activity-dependent differential gene expression by Glu is related to the activation of ionotropic and metabotropic Glu receptors; however, recent findings suggest the involvement of Na+-dependent Glu transporters in this process. Within the retina, Glu uptake is aimed at the replenishment of the releasable pool, and for the prevention of excitotoxicity and is carried mainly by the GLAST/EAAT-1 (Na+-dependent glutamate/aspartate transporter/excitatory amino acids transporter-1) located in Müller radial glia. Based on the previous work showing the alteration of GLAST expression induced by Glu, the present work investigates the involvement of GLAST signalling in the regulation of protein synthesis in Müller cells. To this end, we explored the effect of D-Asp (D-aspartate) on Ser-2448 mTOR (mammalian target of rapamycin) phosphorylation in primary cultures of chick Müller glia. The results showed that D-Asp transport induces the time- and dose-dependent phosphorylation of mTOR, mimicked by the transportable GLAST inhibitor THA (threo-β-hydroxyaspartate). Signalling leading to mTOR phosphorylation includes Ca2+ influx, the activation of p60src, phosphatidylinositol 3-kinase, protein kinase B, mTOR and p70S6K. Interestingly, GLAST activity promoted AP-1 (activator protein-1) binding to DNA, supporting a function for transporter signalling in retinal long-term responses. These results add a novel receptor-independent pathway for Glu signalling in Müller glia, and further strengthen the critical involvement of these cells in the regulation of glutamatergic transmission in the retina. PMID:22817638

Prospects for Pulsar Studies with the GLAST Large Area Telescope

NASA Technical Reports Server (NTRS)

Harding, Alice K.

2007-01-01

The Large Area Telescope (LAT) on the Gamma-ray Large Area Space Telescope (GLAST), due to launch in November 2007, will have unprecedented sensitivity and energy resolution for gamma-rays in the range of 30 MeV to 200 GeV. GLAST is therefore expected to provide major advances in the understanding of high-energy emission from rotation-powered p ulsars. As the only presently known galactic GeV source class, pulsar s will be one of the most important sources for study with GLAST. The main science goals of the LAT for pulsar studies include an increase in the number of detected radio-loud and radio-quiet gamma-ray pulsar s, including millisecond pulsars, giving much better statistics for e lucidating population characteristics, measurement of the high-energy spectrum and the shape of spectral cutoffs and determining pulse profiles for a variety of pulsars of different age. Further, measurement of phase-resolved spectra and energy dependent pulse profiles of the brighter pulsars should allow detailed tests of magnetospheric partic le acceleration and radiation mechanisms, by comparing data with theo retical models that have been developed. Additionally, the LAT will have the sensitivity to allow blind pulsation searches of nearly all un identified EGRET sources, to possibly uncover more radio-quiet Geming a-like pulsars.

Prospects for Pulsar Studies with the GLAST Large Area Telescope

NASA Technical Reports Server (NTRS)

Harding, Alice K.

2007-01-01

The Large Area Telescope (LAT) on the Gamma-ray Large Area Space Telescope (GLAST), due to launch in November 2007, will have unprecedented sensitivity and energy resolution for gamma-rays in the range of 30 MeV to 200 GeV. GLAST is therefore expected to provide major advances in the understanding of high-energy emission from rotation-powered pulsars. As the only presently known galactic GeV source class; pulsars will be one of the most important sources for study with GLAST. The main science goals of the LAT for pulsar studies include an increase in the number of detected radio-loud and radio-quiet gamma-ray pulsars, including millisecond pulsars, giving much better statistics for elucidating population characteristics, measurement of the high-energy spectrum and the shape of spectral cutoffs and determining pulse profiles for a variety of pulsars of different age. Further, measurement of phase-resolved spectra and energy dependent pulse profiles of the brighter pulsars should allow detailed tests of magnetospheric particle acceleration and radiation mechanisms, by comparing data with theoretical models that have been developed. Additionally, the LAT will have the sensitivity to allow blind pulsation searches of nearly all unidentified EGRET sources, to possibly uncover more radio-quiet Geminga-like pulsars.

The Synergy between the LAT and GBM in GLAST's Study of Gamma-Ray Bursts

NASA Technical Reports Server (NTRS)

Band, David L.

2007-01-01

Using semi-analytic calculations I characterize the gamma-ray bursts to which GLAST's LAT and GBM detectors will be sensitive. The thresholds of both instruments are at approximately the same vfv proportional to E(sup 2)N(E) values, i.e., the thresholds can be connected by an E(sup -2) spectrum. Therefore simultaneous detections by both instruments will be biased towards spectral components flatter than E(sup -2).

Performance of the Anti-Coincidence Detector on the GLAST Large Area Telescope

NASA Technical Reports Server (NTRS)

Thompson, D. J.; Charles, E.; Hartman, R. C.; Moiseev, A. A.; Ormes, J. F.

2007-01-01

The Anti-Coincidence Detector (ACD), the outermost detector layer in the Gamma-ray Large Area Space Telescope (GLAST) Large Area Telescope (LAT), is designed to detect and veto incident cosmic ray charged particles, which outnumber cosmic gamma rays by 3-4 orders of magnitude. The challenge in ACD design is that it must have high (0.9997) detection efficiency for singly-charged relativistic particles, but must also have a low probability for self-veto of high-energy gammas by backplash radiation from interactions in the LAT calorimeter. Simulations and tests demonstrate that the ACD meete its design requirements. The performance of the ACD has remained stable thrugh stand-alone environmental testing, shipment across the U.S. installation onto the LAT, shipment back across the U.S., LAT environmental testing, and shipment to Arizona. As part of the fully-assembled GLAST observatory, the ACD is being readied for final testing before launch.

Cosmic-Ray Background Flux Model based on a Gamma-Ray Large-Area Space Telescope Balloon Flight Engineering Model

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mizuno, T

2004-09-03

Cosmic-ray background fluxes were modeled based on existing measurements and theories and are presented here. The model, originally developed for the Gamma-ray Large Area Space Telescope (GLAST) Balloon Experiment, covers the entire solid angle (4{pi} sr), the sensitive energy range of the instrument ({approx} 10 MeV to 100 GeV) and abundant components (proton, alpha, e{sup -}, e{sup +}, {mu}{sup -}, {mu}{sup +} and gamma). It is expressed in analytic functions in which modulations due to the solar activity and the Earth geomagnetism are parameterized. Although the model is intended to be used primarily for the GLAST Balloon Experiment, model functionsmore » in low-Earth orbit are also presented and can be used for other high energy astrophysical missions. The model has been validated via comparison with the data of the GLAST Balloon Experiment.« less

Cosmic-Ray Background Flux Model Baed on a Gamma-Ray Large Area Space Telescope Baloon Flight Engineering

NASA Technical Reports Server (NTRS)

2002-01-01

Cosmic-ray background fluxes were modeled based on existing measurements and theories and are presented here. The model, originally developed for the Gamma-ray Large Area Space Telescope (GLAST) Balloon Experiment, covers the entire solid angle (4(pi) sr), the sensitive energy range of the instrument ((approx) 10 MeV to 100 GeV) and abundant components (proton, alpha, e(sup -), e(sup +), (mu)(sup -), (mu)(sup +) and gamma). It is expressed in analytic functions in which modulations due to the solar activity and the Earth geomagnetism are parameterized. Although the model is intended to be used primarily for the GLAST Balloon Experiment, model functions in low-Earth orbit are also presented and can be used for other high energy astrophysical missions. The model has been validated via comparison with the data of the GLAST Balloon Experiment.

Estimation of Electron Temperature on Glass Spherical Tokamak (GLAST)

NASA Astrophysics Data System (ADS)

Hussain, S.; Sadiq, M.; Shah, S. I. W.; GLAST Team

2015-03-01

Glass Spherical Tokamak (GLAST) is a small spherical tokamak indigenously developed in Pakistan with an insulating vacuum vessel. A commercially available 2.45 GHz magnetron is used as pre-ionization source for plasma current startup. Different diagnostic systems like Rogowski coils, magnetic probes, flux loops, Langmuir probe, fast imaging and emission spectroscopy are installed on the device. The plasma temperature inside of GLAST, at the time of maxima of plasma current, is estimated by taking into account the Spitzer resistivity calculations with some experimentally determined plasma parameters. The plasma resistance is calculated by using Ohm's law with plasma current and loop voltage as experimentally determined inputs. The plasma resistivity is then determined by using length and area of the plasma column. Finally, the average plasma electron temperature is predicted to be 12.65eV for taking neon (Ne) as a working gas.

Searching for Dark Matter Signatures in the GLAST LAT Electron Flux

NASA Technical Reports Server (NTRS)

Moiseev, Alexander; Profumo, Stefano

2008-01-01

We explored several viable scenarios of how LAT might observe DM, when the spectral feature is predicted to be observed in the HE electron flux It has been demonstrated elsewhere that LAT will be capable to detect HE electrons flux in energy range from 20 GeV to - 1 TeV with 520% energy resolution and good statistics If there is a DM-caused feature in the HE electron flux (in the range 20 GeV - 1 TeV), LAT will be the best current instrument to observe it!

Pulsars at the Highest Energies: Questions for AGILE, Fermi (GLAST) and Atmospheric Cherenkov Telescopes

NASA Technical Reports Server (NTRS)

Thompson, D.J.

2008-01-01

Observational studies of gamma-ray pulsars languished in recent years, while theoretical studies made significant strides. Now, with new and improved gamma-ray telescopes coming online, opportunities present themselves for dramatic improvements in our understanding of these objects. The new facilities and better modeling of processes at work in high-energy pulsars should address a number of important open questions, some of which are summarized.

In vitro uptake of glutamate in GLAST- and GLT-1-transfected mutant CHO-K1 cells is inhibited by the ethylmercury-containing preservative thimerosal.

PubMed

Mutkus, Lysette; Aschner, Judy L; Syversen, Tore; Shanker, Gouri; Sonnewald, Ursula; Aschner, Michael

2005-01-01

Thimerosal, also known as thimersal, Merthrolate, or sodiumethyl-mercurithiosalicylate, is an organic mercurial compound that is used in a variety of commercial as well as biomedical applications. As a preservative, it is used in a number of vaccines and pharmaceutical products. Its active ingredient is ethylmercury. Both inorganic and organic mercurials are known to interfere with glutamate homeostasis. Brain glutamate is removed mainly by astrocytes from the extracellular fluid via high-affinity astroglial Na+-dependent excitatory amino acid transporters, glutamate/ aspartate transporter (GLAST) and glutamate transporter-1 (GLT-1). The effects of thimerosal on glutamate homeostasis have yet to be determined. As a first step in this process, we examined the effects of thimerosal on the transport of [3H]-d-aspartate, a nonmetabolizable glutamate analog, in Chinese hamster ovary (CHO) cells transfected with two glutamate transporter subtypes, GLAST (EAAT1) and GLT-1 (EAAT2). Additionally, studies were undertaken to determine the effects of thimerosal on mRNA and protein levels of these transporters. The results indicate that thimerosal treatment caused significant but selective changes in both glutamate transporter mRNA and protein expression in CHO cells. Thimerosal-mediated inhibition of glutamate transport in the CHO-K1 cell line DdB7 was more pronounced in the GLT-1-transfected cells compared with the GLAST- transfected cells. These studies suggest that thimerosal accumulation in the central nervous system might contribute to dysregulation of glutamate homeostasis.

Incorporating LWIR Data into Multi-Frame Blind Deconvolution of Visible Imagery

DTIC Science & Technology

2015-10-18

18.7% 10% 12% Fermi Gamma-ray Space Telescope (GLAST) 19.7% 50% 19% Hubble Space Telescope (HST) (Night 1) 39.9% 20% 15% Iridium 82 14.4% 40% 9...LEO Satellite name Δ Δ ΔMM Delta 1 Rocket Body 12.8% 10% 7% Fermi Gamma-ray Space Telescope (GLAST) 4.3% 10% 6% Hubble Space Telescope (HST) (Night...2) 21.4% 20% -4% Hubble Space Telescope (HST) (Night 3) 41.4% 30% 1% (a) (b) (c) Fig. 3. (a) LWIR image of HST, (b) LWIR image converted

KSC-08pd0783

NASA Image and Video Library

2008-03-21

CAPE CANAVERAL, Fla. --- In the Astrotech payload processing facility, the mechanism on NASA's Gamma-Ray Large Area Space Telescope, or GLAST, solar arrays has been released. The telescope will launch aboard a Delta II rocket May 16 from Launch Pad 17-B on Cape Canaveral Air Force Station. A powerful space observatory, the GLAST will explore the most extreme environments in the universe, and answer questions about supermassive black hole systems, pulsars and the origin of cosmic rays. It also will study the mystery of powerful explosions known as gamma-ray bursts. Photo credit: NASA/Jim Grossmann

KSC-08pd0765

NASA Image and Video Library

2008-03-20

KENNEDY SPACE CENTER, FLA. - In the Astrotech payload processing facility, one of twin solar arrays is positioned on NASA's Gamma-Ray Large Area Space Telescope, or GLAST. The telescope will launch aboard a Delta II rocket May 16 from Launch Pad 17-B on Cape Canaveral Air Force Station. A powerful space observatory, the GLAST will explore the most extreme environments in the universe, and answer questions about supermassive black hole systems, pulsars and the origin of cosmic rays. It also will study the mystery of powerful explosions known as gamma-ray bursts. Photo credit: NASA/Chris Rhodes

The Origin of Cosmic Rays: What can GLAST Say?

NASA Technical Reports Server (NTRS)

Ormes, Jonathan F.; Digel, Seith; Moskalenko, Igor V.; Moiseev, Alexander; Williamson, Roger

2000-01-01

Gamma rays in the band from 30 MeV to 300 GeV, used in combination with direct measurements and with data from radio and X-ray bands, provide a powerful tool for studying the origin of Galactic cosmic rays. Gamma-ray Large Area Space Telescope (GLAST) with its fine 10-20 arcmin angular resolution will be able to map the sites of acceleration of cosmic rays and their interactions with interstellar matter, It will provide information that is necessary to study the acceleration of energetic particles in supernova shocks, their transport in the interstellar medium and penetration into molecular clouds.

KSC-08pd0764

NASA Image and Video Library

2008-03-20

KENNEDY SPACE CENTER, FLA. - In the Astrotech payload processing facility, General Dynamics technicians guide one of twin solar arrays toward NASA's Gamma-Ray Large Area Space Telescope, or GLAST. The telescope will launch aboard a Delta II rocket May 16 from Launch Pad 17-B on Cape Canaveral Air Force Station. A powerful space observatory, the GLAST will explore the most extreme environments in the universe, and answer questions about supermassive black hole systems, pulsars and the origin of cosmic rays. It also will study the mystery of powerful explosions known as gamma-ray bursts. Photo credit: NASA/Chris Rhodes

KSC-08pd0781

NASA Image and Video Library

2008-03-21

CAPE CANAVERAL, Fla. --- In the Astrotech payload processing facility, a General Dynamics technician prepares to test the deployment mechanism on the solar arrays on NASA's Gamma-Ray Large Area Space Telescope, or GLAST. The telescope will launch aboard a Delta II rocket May 16 from Launch Pad 17-B on Cape Canaveral Air Force Station. A powerful space observatory, the GLAST will explore the most extreme environments in the universe, and answer questions about supermassive black hole systems, pulsars and the origin of cosmic rays. It also will study the mystery of powerful explosions known as gamma-ray bursts. Photo credit: NASA/Jim Grossmann

KSC-08pd0784

NASA Image and Video Library

2008-03-21

CAPE CANAVERAL, Fla. --- In the Astrotech payload processing facility, NASA's Gamma-Ray Large Area Space Telescope, or GLAST, completes the test of the deployment mechanism on its solar arrays. The telescope will launch aboard a Delta II rocket May 16 from Launch Pad 17-B on Cape Canaveral Air Force Station. A powerful space observatory, the GLAST will explore the most extreme environments in the universe, and answer questions about supermassive black hole systems, pulsars and the origin of cosmic rays. It also will study the mystery of powerful explosions known as gamma-ray bursts. Photo credit: NASA/Jim Grossmann

KSC-08pd0762

NASA Image and Video Library

2008-03-20

KENNEDY SPACE CENTER, FLA. - In the Astrotech payload processing facility, a General Dynamics technician studies one of twin solar arrays that will be installed on NASA's Gamma-Ray Large Area Space Telescope, or GLAST. The telescope will launch aboard a Delta II rocket May 16 from Launch Pad 17-B on Cape Canaveral Air Force Station. A powerful space observatory, the GLAST will explore the most extreme environments in the universe, and answer questions about supermassive black hole systems, pulsars and the origin of cosmic rays. It also will study the mystery of powerful explosions known as gamma-ray bursts. Photo credit: NASA/Chris Rhodes

KSC-08pd0761

NASA Image and Video Library

2008-03-20

KENNEDY SPACE CENTER, FLA. - In the Astrotech payload processing facility, General Dynamics technicians prepare to install the twin solar arrays on NASA's Gamma-Ray Large Area Space Telescope, or GLAST. The telescope will launch aboard a Delta II rocket May 16 from Launch Pad 17-B on Cape Canaveral Air Force Station. A powerful space observatory, the GLAST will explore the most extreme environments in the universe, and answer questions about supermassive black hole systems, pulsars and the origin of cosmic rays. It also will study the mystery of powerful explosions known as gamma-ray bursts. Photo credit: NASA/Chris Rhodes

KSC-08pd0770

NASA Image and Video Library

2008-03-20

KENNEDY SPACE CENTER, FLA. - In the Astrotech payload processing facility, General Dynamics technicians install the second of twin solar arrays on NASA's Gamma-Ray Large Area Space Telescope, or GLAST. The telescope will launch aboard a Delta II rocket May 16 from Launch Pad 17-B on Cape Canaveral Air Force Station. A powerful space observatory, the GLAST will explore the most extreme environments in the universe, and answer questions about supermassive black hole systems, pulsars and the origin of cosmic rays. It also will study the mystery of powerful explosions known as gamma-ray bursts. Photo credit: NASA/Chris Rhodes

KSC-08pd0763

NASA Image and Video Library

2008-03-20

KENNEDY SPACE CENTER, FLA. - In the Astrotech payload processing facility, General Dynamics technicians lift one of twin solar arrays that will be installed on NASA's Gamma-Ray Large Area Space Telescope, or GLAST. The telescope will launch aboard a Delta II rocket May 16 from Launch Pad 17-B on Cape Canaveral Air Force Station. A powerful space observatory, the GLAST will explore the most extreme environments in the universe, and answer questions about supermassive black hole systems, pulsars and the origin of cosmic rays. It also will study the mystery of powerful explosions known as gamma-ray bursts. Photo credit: NASA/Chris Rhodes

KSC-08pd0782

NASA Image and Video Library

2008-03-21

CAPE CANAVERAL, Fla. --- In the Astrotech payload processing facility, a General Dynamics technician prepares to test the deployment mechanism of the solar arrays on NASA's Gamma-Ray Large Area Space Telescope, or GLAST. The telescope will launch aboard a Delta II rocket May 16 from Launch Pad 17-B on Cape Canaveral Air Force Station. A powerful space observatory, the GLAST will explore the most extreme environments in the universe, and answer questions about supermassive black hole systems, pulsars and the origin of cosmic rays. It also will study the mystery of powerful explosions known as gamma-ray bursts. Photo credit: NASA/Jim Grossmann

KSC-08pd0771

NASA Image and Video Library

2008-03-20

CAPE CANAVERAL, Fla. --- In the Astrotech payload processing facility, a General Dynamics technician finishes the installation of the second of twin solar arrays on NASA's Gamma-Ray Large Area Space Telescope, or GLAST. The telescope will launch aboard a Delta II rocket May 16 from Launch Pad 17-B on Cape Canaveral Air Force Station. A powerful space observatory, the GLAST will explore the most extreme environments in the universe, and answer questions about supermassive black hole systems, pulsars and the origin of cosmic rays. It also will study the mystery of powerful explosions known as gamma-ray bursts. Photo credit: NASA/Chris Rhodes

KSC-08pd0769

NASA Image and Video Library

2008-03-20

KENNEDY SPACE CENTER, FLA. - In the Astrotech payload processing facility, General Dynamics technicians move the second of twin solar arrays toward NASA's Gamma-Ray Large Area Space Telescope, or GLAST. The telescope will launch aboard a Delta II rocket May 16 from Launch Pad 17-B on Cape Canaveral Air Force Station. A powerful space observatory, the GLAST will explore the most extreme environments in the universe, and answer questions about supermassive black hole systems, pulsars and the origin of cosmic rays. It also will study the mystery of powerful explosions known as gamma-ray bursts. Photo credit: NASA/Chris Rhodes

KSC-08pd0766

NASA Image and Video Library

2008-03-20

KENNEDY SPACE CENTER, FLA. - In the Astrotech payload processing facility, General Dynamics technicians install one of twin solar arrays on NASA's Gamma-Ray Large Area Space Telescope, or GLAST. The telescope will launch aboard a Delta II rocket May 16 from Launch Pad 17-B on Cape Canaveral Air Force Station. A powerful space observatory, the GLAST will explore the most extreme environments in the universe, and answer questions about supermassive black hole systems, pulsars and the origin of cosmic rays. It also will study the mystery of powerful explosions known as gamma-ray bursts. Photo credit: NASA/Chris Rhodes

Fermi Sees the Gamma Ray Sky

NASA Image and Video Library

2009-10-30

This view of the gamma-ray sky constructed from one year of Fermi LAT observations is the best view of the extreme universe to date. The map shows the rate at which the LAT detects gamma rays with energies above 300 million electron volts -- about 120 million times the energy of visible light -- from different sky directions. Brighter colors equal higher rates. Credit: NASA/DOE/Fermi LAT Collaboration Full story: www.nasa.gov/mission_pages/GLAST/news/first_year.html

Results from Multiwavelength Workshop for Next Generation Gamma Ray Experiments

NASA Astrophysics Data System (ADS)

Fortson, L.

2002-12-01

The next few years will see the build up of several new gamma-ray detectors both on the ground and in space. By 2006 VERITAS, HESS and MAGIC expect to be operational and GLAST will be in orbit. At the same time, a number of X-ray satellites will be in operation, complementing these new gamma-ray instruments. A better understanding of many high-energy sources can be obtained by making contemporaneous observations with multiple x-ray and gamma-ray instruments. A workshop was recently held at the Adler Planetarium and Astronomy Museum in Chicago to discuss the future of multiwavelength campaigns. The workshop was intended as an opportunity for information exchange within the community to get the best possible science returns from the wealth of data that is expected to come in from the next generation of experiments. By the end of the workshop participants gained a general understanding of the capabilities of the various instruments and their observational strategies. We also came up with a good start on some concrete mechanisms for coordinating gamma-ray observations with ground based and space based observatories at other wavelengths - including X-ray and optical groups. I will report on the results from this workshop in my presentation at the AAS. The workshop was sponsored by the Adler Planetarium and Astronomy Museum.

Development of a Broad High-Energy Gamma-Ray Telescope using Silicon Strip Detectors

NASA Technical Reports Server (NTRS)

Michelson, Peter F.

1998-01-01

The research effort has led to the development and demonstration of technology to enable the design and construction of a next-generation high-energy gamma-ray telescope that operates in the pair-production regime (E greater than 10 MeV). In particular, the technology approach developed is based on silicon-strip detector technology. A complete instrument concept based on this technology for the pair-conversion tracker and the use of CsI(T1) crystals for the calorimeter is now the baseline instrument concept for the Gamma-ray Large Area Space Telescope (GLAST) mission. GLAST is NASA's proposed high-energy gamma-ray mission designed to operate in the energy range from 10 MeV to approximately 300 GeV. GLAST, with nearly 100 times the sensitivity of EGRET, operates through pair conversion of gamma-rays and measurement of the direction and energy of the resulting e (+) - e (-) shower. The baseline design, developed with support from NASA includes a charged particle anticoincidence shield, a tracker/converter made of thin sheets of high-Z material interspersed with Si strip detectors, a CsI calorimeter and a programmable data trigger and acquisition system. The telescope is assembled as an array of modules or towers. Each tower contains elements of the tracker, calorimeter, and anticoincidence system. As originally proposed, the telescope design had 49 modules. In the more optimized design that emerged at the end of the grant period the individual modules are larger and the total number in the GLAST array is 25. Also the calorimeter design was advanced substantially to the point that it has a self-contained imaging capability, albeit much cruder than the tracker.

Connexin-deficiency affects expression levels of glial glutamate transporters within the cerebrum.

PubMed

Unger, Tina; Bette, Stefanie; Zhang, Jiong; Theis, Martin; Engele, Jürgen

2012-01-06

The glial glutamate transporter subtypes, GLT-1/EAAT-2 and GLAST/EAAT-1 clear the bulk of extracellular glutamate and are severely dysregulated in various acute and chronic brain diseases. Despite the previous identification of several extracellular factors modulating glial glutamate transporter expression, our knowledge of the regulatory network controlling glial glutamate transport in health and disease still remains incomplete. In studies with cultured cortical astrocytes, we previously obtained evidence that glial glutamate transporter expression is also affected by gap junctions/connexins. To assess whether gap junctions would likewise control the in vivo expression of glial glutamate transporters, we have now assessed their expression levels in brains of conditional Cx43 knockout mice, total Cx30 knockouts, as well as Cx43/Cx30 double knockouts. We found that either knocking out Cx30, Cx43, or both increases GLT-1/EAAT-2 protein levels in the cerebral cortex to a similar extent. By contrast, GLAST/EAAT-1 protein levels maximally increased in cerebral cortices of Cx30/Cx43 double knockouts, implying that gap junctions differentially affect the expression of GLT-1/EAAT-2 and GLAST/EAAT-1. Quantitative PCR analysis further revealed that increases in glial glutamate transporter expression are brought about by transcriptional and translational/posttranslational processes. Moreover, GLT-1/EAAT-2- and GLAST/EAAT-1 protein levels remained unchanged in the hippocampi of Cx43/Cx30 double knockouts when compared to Cx43fl/fl controls, indicating brain region-specific effects of gap junctions on glial glutamate transport. Since astrocytic gap junction coupling is affected in various forms of brain injuries, our findings point to gap junctions/connexins as important regulators of glial glutamate turnover in the diseased cerebral cortex. Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

Intravitreal injection of exendin-4 analogue protects retinal cells in early diabetic rats.

PubMed

Zhang, Yu; Zhang, Jingfa; Wang, Qingping; Lei, Xia; Chu, Qing; Xu, Guo-Tong; Ye, Wen

2011-01-05

To evaluate the protective effect of intravitreal injection of exendin-4 analogue (E4a) in early diabetic retinopathy (DR) and to explore its possible mechanism. Forty Sprague-Dawley rats were divided into three groups: normal (N), diabetic (D), and E4a-treated diabetic rats (E4a). Diabetes was induced by streptozotocin. Rats in the E4a group were treated with E4a (0.1 μg/2μL/eye), whereas the N and D groups were treated with the equivalent volume of normal saline. Electroretinography was performed at 1 month and 3 months after diabetes onset. Thicknesses and cell counts in each layer of the retina were evaluated. The concentration of glutamate was measured by high-performance liquid chromatography (HPLC). Expressions of glucagon-like peptide-1 receptor (GLP-1R) and GLAST (excitatory amino acid transporter) were detected at mRNA and protein levels and verified by immunohistochemistry in vitro and in vivo. The rMc-1 cells were cultured under high-glucose medium (25 mM), which mimicked diabetic conditions. Effects of E4a (10 μg/mL) were also tested in the rMc-1 culture system. E4a prevented the reduction in b-wave amplitude and oscillatory potential amplitude caused by diabetes. It also prevented the cell loss of outer nuclear layer and inner nuclear layer; the thickness and cell count in the outer nuclear layer were decreased in 1-month diabetic rats. The concentration of glutamate in the retina was higher in diabetic rats and was significantly reduced in the E4a-treated group. Consistent with such changes, retinal GLP-1R and GLAST expression were reduced in the diabetic retina but upregulated in E4a-treated rats. No improvement was found in the retina in both functional and morphologic parameters 3 months after treatment. Intravitreal administration of E4a can prevent the retina, functionally and morphologically, from the insults of diabetes in rats. GLP-1R and GLAST were proved to exist in the rat retina, and their lowered expressions in the diabetic retina might be related to retinal damage by increasing the retinal glutamate. E4a might protect the retina by reducing the glutamate level through upregulating GLP-1R and GLAST, as observed in retinal Müller cells in this study, but this protective effect was transient. Thus, this could be a potential approach for the treatment of DR.

KSC-08pd1138

NASA Image and Video Library

2008-05-04

CAPE CANAVERAL, Fla. -- NASA's Gamma-ray Large Area Space Telescope, or GLAST, spacecraft is moved toward the Hazardous Processing Facility for fueling. The GLAST is a powerful space observatory that will explore the Universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. A launch date still is to be determined. Photo credit: NASA/Jim Grossmann

KSC-08pd1139

NASA Image and Video Library

2008-05-04

CAPE CANAVERAL, Fla. -- NASA's Gamma-ray Large Area Space Telescope, or GLAST, spacecraft is moved into the Hazardous Processing Facility for fueling. The GLAST is a powerful space observatory that will explore the Universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. A launch date still is to be determined. Photo credit: NASA/Jim Grossmann

KSC-08pd0767

NASA Image and Video Library

2008-03-20

KENNEDY SPACE CENTER, FLA. - In the Astrotech payload processing facility, General Dynamics technicians use a socket wrench equipped with a torque meter to tighten the bolts holding one of twin solar arrays to NASA's Gamma-Ray Large Area Space Telescope, or GLAST. The telescope will launch aboard a Delta II rocket May 16 from Launch Pad 17-B on Cape Canaveral Air Force Station. A powerful space observatory, the GLAST will explore the most extreme environments in the universe, and answer questions about supermassive black hole systems, pulsars and the origin of cosmic rays. It also will study the mystery of powerful explosions known as gamma-ray bursts. Photo credit: NASA/Chris Rhodes

KSC-08pd1393

NASA Image and Video Library

2008-05-15

CAPE CANAVERAL, Fla. -- At Astrotech in Titusville, Fla., photographers take photos of NASA's Gamma-Ray Large Area Space Telescope, or GLAST, spacecraft during a press showing. The GLAST is a powerful space observatory that will explore the Universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. A launch date still is to be determined. Photo credit: NASA/Kim Shiflett

KSC-08pd1395

NASA Image and Video Library

2008-05-15

CAPE CANAVERAL, Fla. Photographers take closeup shots of NASA's Gamma-Ray Large Area Space Telescope, or GLAST, spacecraft during a press showing at Astrotech in Titusville, Fla. The GLAST is a powerful space observatory that will explore the Universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. A launch date still is to be determined. Photo credit: NASA/Kim Shiflett

KSC-08pd1038

NASA Image and Video Library

2008-04-25

CAPE CANAVERAL, Fla. – At the Astrotech payload processing facility, technicians give NASA's Gamma-ray Large Area Space Telescope, or GLAST, spacecraft a final cleaning. The GLAST is a powerful space observatory that will explore the Universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. A launch date is still to be determined. Photo credit: NASA/Jim Grossmann

KSC-08pd1036

NASA Image and Video Library

2008-04-25

CAPE CANAVERAL, Fla. – At the Astrotech payload processing facility, technicians conduct black light inspection on NASA's Gamma-ray Large Area Space Telescope, or GLAST, spacecraft. The GLAST is a powerful space observatory that will explore the Universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. A launch date is still to be determined. Photo credit: NASA/Jim Grossmann

KSC-08pd1037

NASA Image and Video Library

2008-04-25

CAPE CANAVERAL, Fla. – At the Astrotech payload processing facility, technicians give NASA's Gamma-ray Large Area Space Telescope, or GLAST, spacecraft a final cleaning. The GLAST is a powerful space observatory that will explore the Universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. A launch date is still to be determined. Photo credit: NASA/Jim Grossmann

KSC-08pd1394

NASA Image and Video Library

2008-05-15

CAPE CANAVERAL, Fla. -- A closeup of NASA's Gamma-Ray Large Area Space Telescope, or GLAST, spacecraft during a press showing at Astrotech in Titusville, Fla. The GLAST is a powerful space observatory that will explore the Universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. A launch date still is to be determined. Photo credit: NASA/Kim Shiflett

KSC-08pd1391

NASA Image and Video Library

2008-05-15

CAPE CANAVERAL, Fla. -- Technicians at Astrotech in Titusville, Fla., work on closeouts of the payload attach fitting on NASA's Gamma-Ray Large Area Space Telescope, or GLAST, spacecraft. The GLAST is a powerful space observatory that will explore the Universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. A launch date still is to be determined. Photo credit: NASA/Kim Shiflett

KSC-08pd1034

NASA Image and Video Library

2008-04-25

CAPE CANAVERAL, Fla. – At the Astrotech payload processing facility, technicians conduct black light inspection on NASA's Gamma-ray Large Area Space Telescope, or GLAST, spacecraft. The GLAST is a powerful space observatory that will explore the Universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. A launch date is still to be determined. Photo credit: NASA/Jim Grossmann

KSC-08pd1389

NASA Image and Video Library

2008-05-15

CAPE CANAVERAL, Fla. -- TvTechnicians at Astrotech in Titusville, Fla., work on closeouts of the payload attach fitting on NASA's Gamma-Ray Large Area Space Telescope, or GLAST, spacecraft. The GLAST is a powerful space observatory that will explore the Universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. A launch date still is to be determined. Photo credit: NASA/Kim Shiflett

KSC-08pd1388

NASA Image and Video Library

2008-05-15

CAPE CANAVERAL, Fla. -- Technicians at Astrotech in Titusville, Fla., work on closeouts of the payload attach fitting on NASA's Gamma-Ray Large Area Space Telescope, or GLAST, spacecraft. The GLAST is a powerful space observatory that will explore the Universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. A launch date still is to be determined. Photo credit: NASA/Kim Shiflett

KSC-08pd1035

NASA Image and Video Library

2008-04-25

CAPE CANAVERAL, Fla. – At the Astrotech payload processing facility, technicians conduct black light inspection on NASA's Gamma-ray Large Area Space Telescope, or GLAST, spacecraft. The GLAST is a powerful space observatory that will explore the Universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. A launch date is still to be determined. Photo credit: NASA/Jim Grossmann

KSC-08pd1392

NASA Image and Video Library

2008-05-15

CAPE CANAVERAL, Fla. -- Technicians at Astrotech in Titusville, Fla., work on closeouts of the payload attach fitting on NASA's Gamma-Ray Large Area Space Telescope, or GLAST, spacecraft. The GLAST is a powerful space observatory that will explore the Universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. A launch date still is to be determined. Photo credit: NASA/Kim Shiflett

KSC-08pd1390

NASA Image and Video Library

2008-05-15

CAPE CANAVERAL, Fla. -- Technicians at Astrotech in Titusville, Fla., work on closeouts of the payload attach fitting on NASA's Gamma-Ray Large Area Space Telescope, or GLAST, spacecraft. The GLAST is a powerful space observatory that will explore the Universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. A launch date still is to be determined. Photo credit: NASA/Kim Shiflett

KSC-08pd0646

NASA Image and Video Library

2008-03-05

KENNEDY SPACE CENTER, FLA. -- In the Astrotech payload processing facility, NASA's Gamma-Ray Large Area Space Telescope, or GLAST, sits uncovered before its move to a work stand in the facility for a complete checkout of the scientific instruments aboard. The telescope will launch aboard a Delta II rocket May 16 from Launch Pad 17-B on Cape Canaveral Air Force Station. A powerful space observatory, the GLAST will explore the most extreme environments in the universe, and answer questions about supermassive black hole systems, pulsars and the origin of cosmic rays. It also will study the mystery of powerful explosions known as gamma-ray bursts. Photo credit: NASA/Kim Shiflett

KSC-08pd0768

NASA Image and Video Library

2008-03-20

KENNEDY SPACE CENTER, FLA. - In the Astrotech payload processing facility, one of twin solar arrays awaits processing as General Dynamics technicians install the other of the pair on NASA's Gamma-Ray Large Area Space Telescope, or GLAST. The telescope will launch aboard a Delta II rocket May 16 from Launch Pad 17-B on Cape Canaveral Air Force Station. A powerful space observatory, the GLAST will explore the most extreme environments in the universe, and answer questions about supermassive black hole systems, pulsars and the origin of cosmic rays. It also will study the mystery of powerful explosions known as gamma-ray bursts. Photo credit: NASA/Chris Rhodes

The Advanced Pair Telescope (APT) Mission Concept

NASA Technical Reports Server (NTRS)

Hunter, Stanley; Buckley, James H.

2008-01-01

We present a mission concept for the Advanced Pair Telescope (APT), a high-energy gamma-ray instrument with an order of magnitude improvement in sensitivity, 6 sr field of view, and angular resolution a factor of 3-10 times that of GLAST. With its very wide instantaneous field-of-view and large effective area, this instrument would be capable of detecting GRBs at very large redshifts, would enable a very high resolution study of SNRs and PWN, and could provide hour-scale temporal resolution of transients from many AGN and galactic sources. The APT instrument will consist of a Xe time-projection-chamber tracker that bridges the energy regime between Compton scattering and pair production and will provide an unprecedented improvement in angular resolution; a thick scintillating-fiber trackerlcalorimeter that will provide sensitivity and energy resolution to higher energies and will possess a factor of 10 improvement in geometric factor over GLAST; and an anticoincidence detector using scintillator-tiles to reject charged particles. After the anticipated 10-years of GLAST operation , the APT instrument would provide continued coverage of the critial high-energy gamma-ray band (between 30 MeV to 100 GeV), providing an essential component of broad-band multiwavelength studies of the high-energy universe.

Gamma Ray Large Area Space Telescope (GLAST) Balloon Flight Engineering Model: Overview

NASA Technical Reports Server (NTRS)

Thompson, D. J.; Godfrey, G.; Williams, S. M.; Grove, J. E.; Mizuno, T.; Sadrozinski, H. F.-W.; Kamae, T.; Ampe, J.; Briber, Stuart; Dann, James;

Toward a next-generation high-energy gamma-ray telescope. Proceedings

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bloom, E.D.; Evans, L.L.

It has been some time between the time of the first Gamma-ray Large Area Space Telescope (GLAST) workshop, Towards a Next Generation High-Energy Gamma-Ray Telescope, in late August 1994, and the publication of a partial proceedings of that meeting. Since then there has been considerable progress in both the technical and project development of GLAST. From its origins at SLAC/Stanford in early 1992, the collaboration has currently grown to more than 20 institutions from France, Germany, Italy, Japan, and the US, and is still growing. About half of these are astrophysics/astronomy institutions; the other half are high-energy physics institutions. Aboutmore » 100 astronomers, astrophysicists, and particle physicists are currently spending some fraction of their time on the GLAST R and D program. The late publication date of this proceedings has resulted in some additions to the original content of the meeting. The first paper is actually a brochure prepared for NASA by Peter Michelson in early 1996. Except for the appendix, the other papers in the proceedings were presented at the conference, and written up over the following two years. Some presentations were never written up.« less

Retinal glutamate transporter changes in experimental glaucoma and after optic nerve transection in the rat.

PubMed

Martin, Keith R G; Levkovitch-Verbin, Hana; Valenta, Danielle; Baumrind, Lisa; Pease, Mary Ellen; Quigley, Harry A

2002-07-01

High levels of glutamate can be toxic to retinal ganglion cells. Effective buffering of extracellular glutamate by retinal glutamate transporters is therefore important. This study was conducted to investigate whether glutamate transporter changes occur with two models of optic nerve injury in the rat. Glaucoma was induced in one eye of 35 adult Wistar rats by translimbal diode laser treatment to the trabecular meshwork. Twenty-five more rats underwent unilateral optic nerve transection. Two glutamate transporters, GLAST (EAAT-1) and GLT-1 (EAAT-2), were studied by immunohistochemistry and quantitative Western blot analysis. Treated and control eyes were compared 3 days and 1, 4, and 6 weeks after injury. Optic nerve damage was assessed semiquantitatively in epoxy-embedded optic nerve cross sections. Trabecular laser treatment resulted in moderate intraocular pressure (IOP) elevation in all animals. After 1 to 6 weeks of experimental glaucoma, all treated eyes had significant optic nerve damage. Glutamate transporter changes were not detected by immunohistochemistry. Western blot analysis demonstrated significantly reduced GLT-1 in glaucomatous eyes compared with control eyes at 3 days (29.3% +/- 6.7%, P = 0.01), 1 week (55.5% +/- 13.6%, P = 0.02), 4 weeks (27.2% +/- 10.1%, P = 0.05), and 6 weeks (38.1% +/- 7.9%, P = 0.01; mean reduction +/- SEM, paired t-tests, n = 5 animals per group, four duplicate Western blot analyses per eye). The magnitude of the reduction in GLT-1 correlated significantly with mean IOP in the glaucomatous eye (r(2) = 0.31, P = 0.01, linear regression). GLAST was significantly reduced (33.8% +/- 8.1%, mean +/- SEM) after 4 weeks of elevated IOP (P = 0.01, paired t-test, n = 5 animals per group). In contrast to glaucoma, optic nerve transection resulted in an increase in GLT-1 compared with the control eye (P = 0.01, paired t-test, n = 15 animals). There was no significant change in GLAST after transection. GLT-1 and GLAST were significantly reduced in an experimental rat glaucoma model, a response that was not found after optic nerve transection. Reductions in GLT-1 and GLAST may increase the potential for glutamate-induced injury to RGC in glaucoma.

Gaudi Evolution for Future Challenges

NASA Astrophysics Data System (ADS)

Clemencic, M.; Hegner, B.; Leggett, C.

2017-10-01

The LHCb Software Framework Gaudi was initially designed and developed almost twenty years ago, when computing was very different from today. It has also been used by a variety of other experiments, including ATLAS, Daya Bay, GLAST, HARP, LZ, and MINERVA. Although it has been always actively developed all these years, stability and backward compatibility have been favoured, reducing the possibilities of adopting new techniques, like multithreaded processing. R&D efforts like GaudiHive have however shown its potential to cope with the new challenges. In view of the LHC second Long Shutdown approaching and to prepare for the computing challenges for the Upgrade of the collider and the detectors, now is a perfect moment to review the design of Gaudi and plan future developments of the project. To do this LHCb, ATLAS and the Future Circular Collider community joined efforts to bring Gaudi forward and prepare it for the upcoming needs of the experiments. We present here how Gaudi will evolve in the next years and the long term development plans.

Roma-BZCAT: a multifrequency catalogue of blazars

NASA Astrophysics Data System (ADS)

Massaro, E.; Giommi, P.; Leto, C.; Marchegiani, P.; Maselli, A.; Perri, M.; Piranomonte, S.; Sclavi, S.

2009-02-01

We present a new catalogue of blazars based on multifrequency surveys and on an extensive review of the literature. Blazars are classified as BL Lacertae objects, as flat spectrum radio quasars or as blazars of uncertain/transitional type. Each object is identified by a root name, coded as BZB, BZQ and BZU for these three subclasses respectively, and by its coordinates. This catalogue is being built as a tool useful for the identification of the extragalactic sources that will be detected by present and future experiments for X and gamma-ray astronomy, like Swift, AGILE, Fermi-GLAST and Simbol-X. An electronic version is available from the ASI Science Data Center web site at http://www.asdc.asi.it/bzcat.

KSC-08pd1412

NASA Image and Video Library

2008-05-17

CAPE CANAVERAL, Fla. -- At pad 17-B at Cape Canaveral Air Force Station, workers attach a cable from the hoist to the GLAST spacecraft to lift it into the mobile service tower. GLAST is a powerful space observatory that will explore the Universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. The launch date is targeted no earlier than June 3. Photo credit: NASA/Kim Shiflett

KSC-08pd0996

NASA Image and Video Library

2008-04-23

CAPE CANAVERAL, Fla. -- At the Astrotech payload processing facility in Titusville, Fla., workers prepare NASA's Gamma-ray Large Area Space Telescope, or GLAST, spacecraft for star tracker sun shade installation. The GLAST is a powerful space observatory that will explore the Universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. A launch date is still to be determined. Photo credit: NASA/Cory Huston

KSC-08pd1032

NASA Image and Video Library

2008-04-25

CAPE CANAVERAL, Fla. – At the Astrotech payload processing facility, technicians install insulation blankets around the star tracker sunshades on NASA's Gamma-ray Large Area Space Telescope, or GLAST, spacecraft. The GLAST is a powerful space observatory that will explore the Universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. A launch date is still to be determined. Photo credit: NASA/Jim Grossmann

KSC-08pd1006

NASA Image and Video Library

2008-04-23

CAPE CANAVERAL, Fla. -- At the Astrotech payload processing facility in Titusville, Fla., a worker adjusts the star tracker sun shade installed on NASA's Gamma-ray Large Area Space Telescope, or GLAST, spacecraft. The GLAST is a powerful space observatory that will explore the Universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. A launch date is still to be determined. Photo credit: NASA/Kim Shiflett

KSC-08pd1005

NASA Image and Video Library

2008-04-23

CAPE CANAVERAL, Fla. -- At the Astrotech payload processing facility in Titusville, Fla., workers install another of the star tracker sun shades on NASA's Gamma-ray Large Area Space Telescope, or GLAST, spacecraft. The GLAST is a powerful space observatory that will explore the Universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. A launch date is still to be determined. Photo credit: NASA/Kim Shiflett

KSC-08pd1031

NASA Image and Video Library

2008-04-25

CAPE CANAVERAL, Fla. – At the Astrotech payload processing facility, technicians install insulation blankets around the star tracker sunshades on NASA's Gamma-ray Large Area Space Telescope, or GLAST, spacecraft. The GLAST is a powerful space observatory that will explore the Universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. A launch date is still to be determined. Photo credit: NASA/Jim Grossmann

KSC-08pd1001

NASA Image and Video Library

2008-04-23

CAPE CANAVERAL, Fla. -- At the Astrotech payload processing facility in Titusville, Fla., workers install one of the star tracker sun shades on NASA's Gamma-ray Large Area Space Telescope, or GLAST, spacecraft. The GLAST is a powerful space observatory that will explore the Universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. A launch date is still to be determined. Photo credit: NASA/Kim Shiflett

KSC-08pd1003

NASA Image and Video Library

2008-04-23

CAPE CANAVERAL, Fla. -- At the Astrotech payload processing facility in Titusville, Fla., a worker adjusts the star tracker sun shades installed on NASA's Gamma-ray Large Area Space Telescope, or GLAST, spacecraft. The GLAST is a powerful space observatory that will explore the Universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. A launch date is still to be determined. Photo credit: NASA/Kim Shiflett

KSC-08pd0997

NASA Image and Video Library

2008-04-23

CAPE CANAVERAL, Fla. -- At the Astrotech payload processing facility in Titusville, Fla., a worker cleans around the area where star tracker sun shades will be installed on NASA's Gamma-ray Large Area Space Telescope, or GLAST, spacecraft. The GLAST is a powerful space observatory that will explore the Universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. A launch date is still to be determined. Photo credit: NASA/Kim Shiflett

KSC-08pd0998

NASA Image and Video Library

2008-04-23

CAPE CANAVERAL, Fla. -- At the Astrotech payload processing facility in Titusville, Fla., the star tracker sun shades are waiting to be installed on NASA's Gamma-ray Large Area Space Telescope, or GLAST, spacecraft. The GLAST is a powerful space observatory that will explore the Universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. A launch date is still to be determined. Photo credit: NASA/Kim Shiflett

KSC-08pd0994

NASA Image and Video Library

2008-04-23

CAPE CANAVERAL, Fla. -- At the Astrotech payload processing facility in Titusville, Fla., workers prepare NASA's Gamma-ray Large Area Space Telescope, or GLAST, spacecraft for star tracker sun shade installation. The GLAST is a powerful space observatory that will explore the Universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. A launch date is still to be determined. Photo credit: NASA/Cory Huston

KSC-08pd1033

NASA Image and Video Library

2008-04-25

CAPE CANAVERAL, Fla. – At the Astrotech payload processing facility, technicians install insulation blankets around the star tracker sunshades on NASA's Gamma-ray Large Area Space Telescope, or GLAST, spacecraft. The GLAST is a powerful space observatory that will explore the Universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. A launch date is still to be determined. Photo credit: NASA/Jim Grossmann

KSC-08pd1000

NASA Image and Video Library

2008-04-23

CAPE CANAVERAL, Fla. -- At the Astrotech payload processing facility in Titusville, Fla., workers install one of the star tracker sun shades on NASA's Gamma-ray Large Area Space Telescope, or GLAST, spacecraft. The GLAST is a powerful space observatory that will explore the Universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. A launch date is still to be determined. Photo credit: NASA/Kim Shiflett

KSC-08pd1137

NASA Image and Video Library

2008-05-04

CAPE CANAVERAL, Fla. -- NASA's Gamma-ray Large Area Space Telescope, or GLAST, spacecraft is moved out of the Astrotech payload processing facility in Titusville, Fla. It is being transported to the Hazardous Processing Facility for fueling. The GLAST is a powerful space observatory that will explore the Universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. A launch date still is to be determined. Photo credit: NASA/Jim Grossmann

KSC-08pd1123

NASA Image and Video Library

2008-05-03

CAPE CANAVERAL, Fla. -- At the Astrotech payload processing facility in Titusville, Fla., NASA's Gamma-ray Large Area Space Telescope, or GLAST, spacecraft is being prepared for its move to the Hazardous Processing Facility for fueling. The GLAST is a powerful space observatory that will explore the universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. A launch date is still to be determined. Photo credit: NASA/Mike Kerley

Design and Characteristics of the Anticoincidence Detector for the GLAST Large Area Telescope

NASA Technical Reports Server (NTRS)

Moiseev, A. A.; Hartman, R. C.; Johnson, T. E.; Ormes, J. F.; Thompson, D. J.

2005-01-01

The Anti-Coincidence Detector (ACD) is the outermost detector layer in the GLAST Large Area Telescope (LAT), surrounding the top and sides of the tracker. The purpose of the ACD is to detect and veto incident cosmic ray charged particles, which outnumber cosmic gamma rays by 3-4 orders of magnitude. The challenge in ACD design is that it must have high (0.9997) detection efficiency for singly charged relativistic particles, but must also have low sensitivity to backsplash particles. These are products of high- energy interactions in the LAT calorimeter. They can cause a veto signal in the ACD, resulting in loss of good gamma-ray events.

KSC-08pd0645

NASA Image and Video Library

2008-03-05

KENNEDY SPACE CENTER, FLA. -- General Dynamics technicians in the Astrotech payload processing facility remove the protective cover over NASA's Gamma-Ray Large Area Space Telescope, or GLAST. The space telescope will be moved to a work stand in the facility for a complete checkout of the scientific instruments aboard. The telescope will launch aboard a Delta II rocket May 16 from Launch Pad 17-B on Cape Canaveral Air Force Station. A powerful space observatory, the GLAST will explore the most extreme environments in the universe, and answer questions about supermassive black hole systems, pulsars and the origin of cosmic rays. It also will study the mystery of powerful explosions known as gamma-ray bursts. Photo credit: NASA/Kim Shiflett

Observation and Simulations of the Backsplash Effects in High-Energy Gamma-Ray Telescopes Containing a Massive Calorimeter

NASA Technical Reports Server (NTRS)

Moiseev, Alexander A.; Ormes, Jonathan F.; Hartman, Robert C.; Johnson, Thomas E.; Mitchell, John W.; Thompson, David J.

1999-01-01

Beam test and simulation results are presented for a study of the backsplash effects produced in a high-energy gamma-ray detector containing a massive calorimeter. An empirical formula is developed to estimate the probability (per unit area) of backsplash for different calorimeter materials and thicknesses, different incident particle energies, and at different distances from the calorimeter. The results obtained are applied to the design of Anti-Coincidence Detector (ACD) for the Large Area Telescope (LAT) on the Gamma-ray Large Area Space Telescope (GLAST).

Gamma Ray Pulsars: Multiwavelength Observations

NASA Technical Reports Server (NTRS)

Thompson, David J.

2004-01-01

High-energy gamma rays are a valuable tool for studying particle acceleration and radiation in the magnetospheres of energetic pulsars. The seven or more pulsars seen by instruments on the Compton Gamma Ray Observatory (CGRO) show that: the light curves usually have double-peak structures (suggesting a broad cone of emission); gamma rays are frequently the dominant component of the radiated power; and all the spectra show evidence of a high-energy turnover. For all the known gamma-ray pulsars, multiwavelength observations and theoretical models based on such observations offer the prospect of gaining a broad understanding of these rotating neutron stars. The Gamma-ray Large Area Space Telescope (GLAST), now in planning for a launch in 2006, will provide a major advance in sensitivity, energy range, and sky coverage.

KSC-08pd1619

NASA Image and Video Library

2008-06-11

CAPE CANAVERAL, Fla. -- NASA's Gamma-ray Large Area Space Telescope, or GLAST, spacecraft atop the Delta II rocket is spotlighted after rollback of the mobile service tower on Cape Canaveral Air Force Station's Launch Pad 17-B. GLAST is a powerful space observatory that will explore the universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. Launch is scheduled for 11:45 a.m. June 11. Photo credit: NASA/Dimitri Gerondidakis

KSC-08pd0166

NASA Image and Video Library

2008-02-06

KENNEDY SPACE CENTER, FLA. -- The truck carrying the United Launch Alliance Delta II first stage arrives at Hangar M on Cape Canaveral Air Force Station in Florida. The Delta rocket will be used to launch the Gamma-Ray Large Area Space Telescope, or GLAST, in May from Launch Pad 17-B on CCAFS. The GLAST is a powerful space observatory that will explore the Universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. Photo credit: NASA/George Shelton

KSC-08pd0167

NASA Image and Video Library

2008-02-06

KENNEDY SPACE CENTER, FLA. -- The truck carrying the United Launch Alliance Delta II first stage backs into Hangar M on Cape Canaveral Air Force Station in Florida. The Delta rocket will be used to launch the Gamma-Ray Large Area Space Telescope, or GLAST, in May from Launch Pad 17-B on CCAFS. The GLAST is a powerful space observatory that will explore the Universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. Photo credit: NASA/George Shelton

KSC-08pd1633

NASA Image and Video Library

2008-06-11

CAPE CANAVERAL, Fla. -- Smoke is generated at liftoff of NASA's Gamma-Ray Large Area Space Telescope , or GLAST, aboard a Delta II rocket from Cape Canaveral Air Force Station's Launch Pad 17-B. Liftoff was at 12:05 p.m. EDT. GLAST is a powerful space observatory that will explore the universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. Launch is scheduled for 11:45 a.m. June 11. Photo credit: NASA/Tony Gray, Regina Mitchell-Ryall

KSC-08pd1642

NASA Image and Video Library

2008-06-11

CAPE CANAVERAL, Fla. -- Smoke envelops the Delta II rocket with NASA's Gamma-Ray Large Area Space Telescope , or GLAST, aboard as it launches from Cape Canaveral Air Force Station's Launch Pad 17-B. Liftoff was at 12:05 p.m. EDT. GLAST is a powerful space observatory that will explore the universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. Launch is scheduled for 11:45 a.m. June 11. Photo credit: NASA/Jerry Cannon, Robert Murray

KSC-08pd1635

NASA Image and Video Library

2008-06-11

CAPE CANAVERAL, Fla. -- Smoke is generated at liftoff of NASA's Gamma-Ray Large Area Space Telescope , or GLAST, aboard a Delta II rocket from Cape Canaveral Air Force Station's Launch Pad 17-B. Liftoff was at 12:05 p.m. EDT. GLAST is a powerful space observatory that will explore the universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. Launch is scheduled for 11:45 a.m. June 11. Photo credit: NASA/Tony Gray, Regina Mitchell-Ryall

KSC-08pd1126

NASA Image and Video Library

2008-05-03

CAPE CANAVERAL, Fla. -- At the Astrotech payload processing facility in Titusville, Fla., technicians lower the overhead crane onto NASA's Gamma-ray Large Area Space Telescope, or GLAST, spacecraft. The spacecraft is being prepared for its move to the Hazardous Processing Facility for fueling. The GLAST is a powerful space observatory that will explore the universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. A launch date is still to be determined. Photo credit: NASA/Mike Kerley

KSC-08pd1124

NASA Image and Video Library

2008-05-03

CAPE CANAVERAL, Fla. -- At the Astrotech payload processing facility in Titusville, Fla., technicians prepare NASA's Gamma-ray Large Area Space Telescope, or GLAST, spacecraft for attachment of an overhead crane. The spacecraft is being prepared for its move to the Hazardous Processing Facility for fueling. The GLAST is a powerful space observatory that will explore the universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. A launch date is still to be determined. Photo credit: NASA/Mike Kerley

KSC-08pd1354

NASA Image and Video Library

2008-05-14

CAPE CANAVERAL, Fla. -- At the Astrotech payload processing facility, NASA's Gamma-Ray Large Area Space Telescope, or GLAST, spacecraft will be installed on this payload attach fitting that will eventually be mated to the Delta II launch vehicle. The GLAST is a powerful space observatory that will explore the Universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. A launch date still is to be determined. Photo credit: NASA/Jim Grossmann

Effects of Orally Administered Augmentin on Glutamate Transporter 1, Cystine-glutamate Exchanger Expression as well as Ethanol Intake in Alcohol-Preferring Rats

PubMed Central

Hakami, Alqassem Y.; Alshehri, Fahad S.; Althobaiti, Yusuf S.; Sari, Youssef

2016-01-01

Alcohol dependence is associated with deficits in glutamate uptake and impairment of glutamate homeostasis in different brain reward regions. Glutamate transporter subtype 1 (GLT-1), cystine-glutamate exchanger (xCT) and glutamate/aspartate transporter (GLAST) are the key players in regulating extracellular glutamate concentration in the brain. Parenteral treatment with ceftriaxone, β-lactam antibiotic, has been reported to attenuate ethanol consumption and reinstatement to cocaine-seeking behavior, in part, by restoring the expression of GLT-1 and xCT in mesocorticolimbic brain regions in rats. In this study, we focus to test Augmentin (amoxicillin/clavulanate), which can be administered orally to subjects. Therefore, we examined the effects of orally administered Augmentin on ethanol intake as well as GLT-1, xCT and GLAST expression in alcohol-preferring (P) rats. We found that orally administered Augmentin significantly attenuated ethanol consumption in P rats as compared to the vehicle-treated group. Importantly, the attenuation in ethanol consumption was associated with a significant upregulation of GLT-1 and xCT expression in nucleus accumbens (NAc) and prefrontal cortex (PFC). There was no effect of oral Augmentin on GLAST expression in either NAc or PFC. These findings present strong evidence that oral administration of Augmentin can be used as an alternative to parenteral administration. PMID:27993695

Effects of orally administered Augmentin on glutamate transporter 1, cystine-glutamate exchanger expression and ethanol intake in alcohol-preferring rats.

PubMed

Hakami, Alqassem Y; Alshehri, Fahad S; Althobaiti, Yusuf S; Sari, Youssef

2017-03-01

Alcohol dependence is associated with deficits in glutamate uptake and impairment of glutamate homeostasis in different brain reward regions. Glutamate transporter subtype 1 (GLT-1), cystine-glutamate exchanger (xCT) and glutamate/aspartate transporter (GLAST) are one of the key players in regulating extracellular glutamate concentration in the brain. Parenteral treatment with ceftriaxone, β-lactam antibiotic, has been reported to attenuate ethanol consumption and reinstatement to cocaine-seeking behavior, in part, by restoring the expression of GLT-1 and xCT in mesocorticolimbic brain regions in rats. In this study, we focused to test Augmentin (amoxicillin/clavulanate), which can be administered orally to subjects. Therefore, we examined the effects of orally administered Augmentin on ethanol intake as well as GLT-1, xCT and GLAST expression in male alcohol-preferring (P) rats. We found that orally administered Augmentin significantly attenuated ethanol consumption in P rats as compared to the vehicle-treated group. Importantly, the attenuation in ethanol consumption was associated with a significant upregulation of GLT-1 and xCT expression in nucleus accumbens (NAc) and prefrontal cortex (PFC). There was no effect of orally administered Augmentin on GLAST expression in either NAc or PFC. These findings present strong evidence that oral administration of Augmentin can be used as an alternative to parenteral treatment. Copyright © 2016 Elsevier B.V. All rights reserved.

Pre-launch estimates for GLAST sensitivity to dark matter annihilation signals

DOE PAGES

Baltz, E. A.; Berenji, B.; Bertone, G.; ...

2008-07-17

Here, we investigate the sensitivity of the Gamma-ray Large Area Space Telescope (GLAST) to indirectly detect weakly interacting massive particles (WIMPs) through the γ-ray signal that their pair annihilation produces. WIMPs are among the favorite candidates to explain the compelling evidence that about 80% of the mass in the Universe is non-baryonic dark matter (DM). They are serendipitously motivated by various extensions of the standard model of particle physics such as Supersymmetry and Universal Extra Dimensions (UED). With its unprecedented sensitivity and its very large energy range (20 MeV to more than 300 GeV) the main instrument on board themore » GLAST satellite, the Large Area Telescope (LAT), will open a new window of discovery. As our estimates show, the LAT will be able to detect an indirect DM signature for a large class of WIMP models given a cuspy profile for the DM distribution. Using the current state of the art Monte Carlo and event reconstruction software developed within the LAT collaboration, we present preliminary sensitivity studies for several possible sources inside and outside the Galaxy. Lastly, we also discuss the potential of the LAT to detect UED via the electron/positron channel. Diffuse background modeling and other background issues that will be important in setting limits or seeing a signal are presented.« less

Monitoring the Low-Energy Gamma-Ray Sky Using Earth Occultation with GLAST GBM

NASA Technical Reports Server (NTRS)

Case, G.; Wilson-Hodge, C.; Cherry, M.; Kippen, M.; Ling, J.; Radocinski, R.; Wheaton, W.

2007-01-01

Long term all-sky monitoring of the 20 keV - 2 MeV gamma-ray sky using the Earth occultation technique was demonstrated by the BATSE instrument on the Compton Gamma Ray Observatory. The principles and techniques used for the development of an end-to-end earth occultation data analysis system for BATSE can be extended to the GLAST Gamma-ray Burst Monitor (GBM), resulting in multiband light curves and time-resolved spectra in the energy range 8 keV to above 1 MeV for known gamma-ray sources and transient outbursts, as well as the discovery of new sources of gamma-ray emission. In this paper we describe the application of the technique to the GBM. We also present the expected sensitivity for the GBM.

KSC-08pd0951

NASA Image and Video Library

2008-04-15

CAPE CANAVERAL, Fla. -- In the Astrotech payload processing facility near NASA's Kennedy Space Center, General Dynamics technicians, sitting beneath the Gamma-ray Large Area Space Telescope, or GLAST, position a high-gain antenna under the spacecraft before it is installed. The GLAST is a powerful space observatory that will explore the universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. Launch is currently planned in a window between 11:45 a.m. and 1:40 p.m. EDT May 16. Photo credit: NASA/Kim Shiflett

KSC-08pd1630

NASA Image and Video Library

2008-06-11

CAPE CANAVERAL, Fla. -- Under cloud-dotted blue sky, NASA's Gamma-Ray Large Area Space Telescope , or GLAST, blasts off from Cape Canaveral Air Force Station's Launch Pad 17-B aboard a Delta II rocket. Liftoff was at 12:05 p.m. EDT. GLAST is a powerful space observatory that will explore the universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. Launch is scheduled for 11:45 a.m. June 11. Photo credit: NASA/Sandra Joseph, Kevin O'Connel

KSC-08pd1631

NASA Image and Video Library

2008-06-11

CAPE CANAVERAL, Fla. -- The Delta II rocket with NASA's Gamma-Ray Large Area Space Telescope , or GLAST, on top is bathed in smoke just after liftoff from Cape Canaveral Air Force Station's Launch Pad 17-B. Liftoff was at 12:05 p.m. EDT. GLAST is a powerful space observatory that will explore the universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. Launch is scheduled for 11:45 a.m. June 11. Photo credit: NASA/Sandra Joseph, Kevin O'Connel

KSC-08pd1641

NASA Image and Video Library

2008-06-11

CAPE CANAVERAL, Fla. -- On Cape Canaveral Air Force Station's Launch Pad 17-B, flame and smoke mark the launch of the Delta II rocket with NASA's Gamma-Ray Large Area Space Telescope , or GLAST, aboard. Liftoff was at 12:05 p.m. EDT. GLAST is a powerful space observatory that will explore the universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. Launch is scheduled for 11:45 a.m. June 11. Photo credit: NASA/Jerry Cannon, Robert Murray

KSC-08pd1636

NASA Image and Video Library

2008-06-11

CAPE CANAVERAL, Fla. -- Smoke rises to obscure the Delta II rocket with NASA's Gamma-Ray Large Area Space Telescope , or GLAST, aboard as it launches from Cape Canaveral Air Force Station's Launch Pad 17-B. Liftoff was at 12:05 p.m. EDT. GLAST is a powerful space observatory that will explore the universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. Launch is scheduled for 11:45 a.m. June 11. Photo credit: NASA/Tony Gray, Regina Mitchell-Ryall

KSC-08pd0948

NASA Image and Video Library

2008-04-15

CAPE CANAVERAL, Fla. -- In the Astrotech payload processing facility near NASA's Kennedy Space Center, General Dynamics technicians prepare the Gamma-ray Large Area Space Telescope, or GLAST, for the installation of its high-gain antenna. The GLAST is a powerful space observatory that will explore the universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. Launch is currently planned in a window between 11:45 a.m. and 1:40 p.m. EDT May 16. Photo credit: NASA/Kim Shiflett

KSC-08pd1620

NASA Image and Video Library

2008-06-11

CAPE CANAVERAL, Fla. -- On Cape Canaveral Air Force Station's Launch Pad 17-B, NASA's Gamma-ray Large Area Space Telescope , or GLAST, sits poised for launch atop the United Launch Alliance Delta II rocket after rollback of the mobile service tower. GLAST is a powerful space observatory that will explore the universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. Launch is scheduled for 11:45 a.m. June 11. Photo credit: Carleton Bailie photograph for United Launch Alliance

KSC-08pd1621

NASA Image and Video Library

2008-06-11

CAPE CANAVERAL, Fla. -- On Cape Canaveral Air Force Station's Launch Pad 17-B, NASA's Gamma-ray Large Area Space Telescope , or GLAST, sits poised for launch atop the United Launch Alliance Delta II rocket after rollback of the mobile service tower. GLAST is a powerful space observatory that will explore the universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. Launch is scheduled for 11:45 a.m. June 11. Photo credit: Carleton Bailie photograph for United Launch Alliance

KSC-08pd1623

NASA Image and Video Library

2008-06-11

CAPE CANAVERAL, Fla. -- On Cape Canaveral Air Force Station's Launch Pad 17-B, NASA's Gamma-ray Large Area Space Telescope , or GLAST, sits poised for launch atop the United Launch Alliance Delta II rocket after rollback of the mobile service tower. GLAST is a powerful space observatory that will explore the universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. Launch is scheduled for 11:45 a.m. June 11. Photo credit: Carleton Bailie photograph for United Launch Alliance

KSC-08pd1411

NASA Image and Video Library

2008-05-17

CAPE CANAVERAL, Fla. -- The GLAST spacecraft arrives at pad 17-B at Cape Canaveral Air Force Station aboard its transporter. At the pad, NASA's Gamma-Ray Large Area Space Telescope will be lifted into the mobile service tower and attached to the Delta II second stage. GLAST is a powerful space observatory that will explore the Universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. The launch date is targeted no earlier than June 3. Photo credit: NASA/Kim Shiflett

KSC-08pd0950

NASA Image and Video Library

2008-04-15

CAPE CANAVERAL, Fla. -- In the Astrotech payload processing facility near NASA's Kennedy Space Center, General Dynamics technicians put the finishing touches on a high-gain antenna that will be installed on the Gamma-ray Large Area Space Telescope, or GLAST. The GLAST is a powerful space observatory that will explore the universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. Launch is currently planned in a window between 11:45 a.m. and 1:40 p.m. EDT May 16. Photo credit: NASA/Kim Shiflett

KSC-08pd1622

NASA Image and Video Library

2008-06-11

CAPE CANAVERAL, Fla. -- On Cape Canaveral Air Force Station's Launch Pad 17-B, NASA's Gamma-ray Large Area Space Telescope , or GLAST, sits poised for launch atop the United Launch Alliance Delta II rocket after rollback of the mobile service tower. GLAST is a powerful space observatory that will explore the universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. Launch is scheduled for 11:45 a.m. June 11. Photo credit: Carleton Bailie photograph for United Launch Alliance

KSC-08pd1640

NASA Image and Video Library

2008-06-11

CAPE CANAVERAL, Fla. -- Smoke appears to grab at the Delta II rocket as it launches from Cape Canaveral Air Force Station's Launch Pad 17-B with NASA's Gamma-Ray Large Area Space Telescope , or GLAST, aboard. Liftoff was at 12:05 p.m. EDT. GLAST is a powerful space observatory that will explore the universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. Launch is scheduled for 11:45 a.m. June 11. Photo credit: NASA/Jerry Cannon, Robert Murray

KSC-08pd0168

NASA Image and Video Library

2008-02-06

KENNEDY SPACE CENTER, FLA. -- Workers in Hangar M on Cape Canaveral Air Force Station in Florida open the truck trailer to offload the United Launch Alliance Delta II first stage. The Delta rocket will be used to launch the Gamma-Ray Large Area Space Telescope, or GLAST, in May from Launch Pad 17-B on CCAFS. The GLAST is a powerful space observatory that will explore the Universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. Photo credit: NASA/George Shelton

KSC-08pd0949

NASA Image and Video Library

2008-04-15

CAPE CANAVERAL, Fla. -- In the Astrotech payload processing facility near NASA's Kennedy Space Center, General Dynamics technicians prepare a high-gain antenna for installation on the Gamma-ray Large Area Space Telescope, or GLAST. The GLAST is a powerful space observatory that will explore the universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. Launch is currently planned in a window between 11:45 a.m. and 1:40 p.m. EDT May 16. Photo credit: NASA/Kim Shiflett

KSC-08pd1128

NASA Image and Video Library

2008-05-03

CAPE CANAVERAL, Fla. -- At the Astrotech payload processing facility in Titusville, Fla., technicians check the NASA's Gamma-ray Large Area Space Telescope, or GLAST, spacecraft after being lowered toward the transporter. The spacecraft is being prepared for its move to the Hazardous Processing Facility for fueling. The GLAST is a powerful space observatory that will explore the universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. A launch date is still to be determined. Photo credit: NASA/Mike Kerley

KSC-08pd1130

NASA Image and Video Library

2008-05-03

CAPE CANAVERAL, Fla. -- At the Astrotech payload processing facility in Titusville, Fla., technicians monitor NASA's Gamma-ray Large Area Space Telescope, or GLAST, spacecraft as it is lowered onto a transporter. The spacecraft is being prepared for its move to the Hazardous Processing Facility for fueling. The GLAST is a powerful space observatory that will explore the universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. A launch date is still to be determined. Photo credit: NASA/Mike Kerley

KSC-08pd1127

NASA Image and Video Library

2008-05-03

CAPE CANAVERAL, Fla. -- At the Astrotech payload processing facility in Titusville, Fla., technicians lift and move via an overhead crane NASA's Gamma-ray Large Area Space Telescope, or GLAST, spacecraft onto a transporter. The spacecraft is being prepared for its move to the Hazardous Processing Facility for fueling. The GLAST is a powerful space observatory that will explore the universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. A launch date is still to be determined. Photo credit: NASA/Mike Kerley

KSC-08pd1125

NASA Image and Video Library

2008-05-03

CAPE CANAVERAL, Fla. -- At the Astrotech payload processing facility in Titusville, Fla., technicians attach the cables to the overhead crane that will be used to lift NASA's Gamma-ray Large Area Space Telescope, or GLAST, spacecraft. The spacecraft is being prepared for its move to the Hazardous Processing Facility for fueling. The GLAST is a powerful space observatory that will explore the universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. A launch date is still to be determined. Photo credit: NASA/Mike Kerley

KSC-08pd1129

NASA Image and Video Library

2008-05-03

CAPE CANAVERAL, Fla. -- At the Astrotech payload processing facility in Titusville, Fla., the overhead crane continues to lower NASA's Gamma-ray Large Area Space Telescope, or GLAST, spacecraft onto the transporter. The spacecraft is being prepared for its move to the Hazardous Processing Facility for fueling. The GLAST is a powerful space observatory that will explore the universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. A launch date is still to be determined. Photo credit: NASA/Mike Kerley

KSC-08pd1132

NASA Image and Video Library

2008-05-03

CAPE CANAVERAL, Fla. -- At the Astrotech payload processing facility in Titusville, Fla., technicians check various parts of NASA's Gamma-ray Large Area Space Telescope, or GLAST, spacecraft after its transfer to a transporter. The spacecraft is being prepared for its move to the Hazardous Processing Facility for fueling. The GLAST is a powerful space observatory that will explore the universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. A launch date is still to be determined. Photo credit: NASA/Mike Kerley

KSC-08pd1131

NASA Image and Video Library

2008-05-03

CAPE CANAVERAL, Fla. -- At the Astrotech payload processing facility in Titusville, Fla., technicians check various parts of NASA's Gamma-ray Large Area Space Telescope, or GLAST, spacecraft after its transfer to a transporter. The spacecraft is being prepared for its move to the Hazardous Processing Facility for fueling. The GLAST is a powerful space observatory that will explore the universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. A launch date is still to be determined. Photo credit: NASA/Mike Kerley

The Fermi Large Area Telescope: Optimizing and Then Re-Optimizing the Science Return

NASA Astrophysics Data System (ADS)

Atwood, W. B.

2012-01-01

The general concepts of how to do gamma-ray observations in space were well established and vetted by the early 1990's. In particular, the success of EGRET onboard the Compton Gamma Ray Observatory whetted the appetite for a more ambitious follow on. In parallel, advances in high-energy particle detection, spurred on by plans for the Superconducting Super Collider, provided an unprecedented opportunity for space-based detectors. The GLAST concept, now Fermi-LAT, was born at SLAC in May of 1992 and the instrument was subsequently developed by an international collaboration from France, Italy, Japan, Sweden and the United States. An overview of the original design optimization of the LAT instrument, done with the goal of imposing as few limits as possible on its applications in space, is discussed (along with some of the trials and tribulations of construction along the way to launch!). Now with over 3 years of science operations experience, the lessons-learned will be reviewed and assessed against the expectations. Finally, the ongoing re-optimization of the instrument and plans for how to extend the LAT's science window into the future are discussed.

Digging for the Truth: Photon Archeology with GLAST

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stecker, F. W.

2007-07-12

Stecker, Malkan and Scully, have shown how ongoing deep surveys of galaxy luminosity functions, spectral energy distributions and backwards evolution models of star formation rates can be used to calculate the past history of intergalactic photon densities for energies from 0.03 eV to the Lyman limit at 13.6 eV and for redshifts out to 6 (called here the intergalactic background light or IBL). From these calculations of the IBL at various redshifts, they predict the present and past optical depth of the universe to high energy {gamma}-rays owing to interactions with photons of the IBL and the 2.7 K CMB.more » We discuss here how this proceedure can be reversed by looking for sharp cutoffs in the spectra of extragalactic {gamma}-ray sources such as blazars at high redshifts in the multi-GeV energy range with GLAST (Gamma-Ray Large Are Space Telescope). By determining the cutoff energies of sources with known redshifts, we can refine our determination of the IBL photon densities in the past, i.e., the archeo-IBL, and therefore get a better measure of the past history of the total star formation rate. Conversely, observations of sharp high energy cutoffs in the {gamma}-ray spectra of sources at unknown redshifts can be used instead of spectral lines to give a measure of their redshifts.« less

Reliable Genetic Labeling of Adult-Born Dentate Granule Cells Using Ascl1 CreERT2 and Glast CreERT2 Murine Lines.

PubMed

Yang, Sung M; Alvarez, Diego D; Schinder, Alejandro F

2015-11-18

Newly generated dentate granule cells (GCs) are relevant for input discrimination in the adult hippocampus. Yet, their precise contribution to information processing remains unclear. To address this question, it is essential to develop approaches to precisely label entire cohorts of adult-born GCs. In this work, we used genetically modified mice to allow conditional expression of tdTomato (Tom) in adult-born GCs and characterized their development and functional integration. Ascl1(CreERT2);CAG(floxStopTom) and Glast(CreERT2);CAG(floxStopTom) mice resulted in indelible expression of Tom in adult neural stem cells and their lineage upon tamoxifen induction. Whole-cell recordings were performed to measure intrinsic excitability, firing behavior, and afferent excitatory connectivity. Developing GCs were also staged by the expression of early and late neuronal markers. The slow development of adult-born GCs characterized here is consistent with previous reports using retroviral approaches that have revealed that a mature phenotype is typically achieved after 6-8 weeks. Our findings demonstrate that Ascl1(CreERT2) and Glast(CreERT2) mouse lines enable simple and reliable labeling of adult-born GC lineages within restricted time windows. Therefore, these mice greatly facilitate tagging new neurons and manipulating their activity, required for understanding adult neurogenesis in the context of network remodeling, learning, and behavior. Our study shows that Ascl1(CreERT2) and Glast(CreERT2) mice lines can be used to label large cohorts of adult-born dentate granule cells with excellent time resolution. Neurons labeled in this manner display developmental and functional profiles that are in full agreement with previous findings using thymidine analogs and retroviral labeling, thus providing an alternative approach to tackle fundamental questions on circuit remodeling. Because of the massive neuronal targeting and the simplicity of this method, genetic labeling will contribute to expand research on adult neurogenesis. Copyright © 2015 the authors 0270-6474/15/3515379-12$15.00/0.

An Intriguing Convex Break in the EGRET SED of Mrk 421

NASA Technical Reports Server (NTRS)

Nandikotkur, Giridhar; Jahoda, Keith M.; Georganopoulos, M.; Hartman, R. C.; Mukherjee, R.; Thompson, D. J.; Swank, Jean H.

2007-01-01

Based upon analysis of the entire EGRET data from Mrk 421, it is found that the time-averaged spectra are inconsistent with the predictions of current theoretical models that have had success in describing simultaneous X-ray/TeV observations, and suggest additional components in the GeV band, as well as complex time variability. Current theoretical pictures explain the GeV emission as comptonization of the synchrotron photons in the jet, and predict hard spectra that should join smoothly with the TeV emission. Our analysis shows that the situation is more complex. The spectrum ranges from hard to soft during individual epochs, and shows a convext break in the aggregated data. We also present the mission-averaged EGRET spectrum for PKS 2155-304, which shows a similar (but not as pronounced) convex curvature. We discuss a series of possible explanations for the 10(exp 22) - 10(exp 23) HZ declining part of the EGRET nu F(sub nu), spectrum for Mrk 421, and suggest that it is synchrotron emission from the high energy tail of the electron population that produces the X-rays during the highest X-ray states. Such multi-MeV photons are produced by electrons accelerated close to the limit of diffusive shock acceleration. Simultaneous GLAST and X-ray observations of high X-ray states will address the issue of the convex curvature in the future.

Altered cerebellar development in nuclear receptor TAK1/ TR4 null mice is associated with deficits in GLAST(+) glia, alterations in social behavior, motor learning, startle reactivity, and microglia.

PubMed

Kim, Yong-Sik; Harry, G Jean; Kang, Hong Soon; Goulding, David; Wine, Rob N; Kissling, Grace E; Liao, Grace; Jetten, Anton M

2010-09-01

Previously, deficiency in the expression of the nuclear orphan receptor TAK1 was found to be associated with delayed cerebellar granule cell migration and Purkinje cell maturation with a permanent deficit in foliation of lobules VI–VII, suggesting a role for TAK1 in cerebellum development. In this study, we confirm that TAK1-deficient (TAK1(−/−)) mice have a smaller cerebellum and exhibit a disruption of lobules VI–VII. We extended these studies and show that at postnatal day 7, TAK1(−/−) mice exhibit a delay in monolayer maturation of dysmorphic calbindin 28K-positive Purkinje cells. The astrocyte-specific glutamate transporter (GLAST) was expressed within Bergmann fibers and internal granule cell layer at significantly lower levels in the cerebellum of TAK1(−/−) mice. At PND21, Golgi-positive Purkinje cells in TAK1(−/−) mice displayed a smaller soma (18%) and shorter distance to first branch point (35%). Neuronal death was not observed in TAK1(−/−) mice at PND21; however, activated microglia were present in the cerebellum, suggestive of earlier cell death. These structural deficits in the cerebellum were not sufficient to alter motor strength, coordination, or activity levels; however, deficits in acoustic startle response, prepulse startle inhibition, and social interactions were observed. Reactions to a novel environment were inhibited in a light/dark chamber, open-field, and home-cage running wheel. TAK1(−/−) mice displayed a plateau in performance on the running wheel, suggesting a deficit in learning to coordinate performance on a motor task. These data indicate that TAK1 is an important transcriptional modulator of cerebellar development and neurodevelopmentally regulated behavior.

KSC-08pd0848

NASA Image and Video Library

2008-03-27

CAPE CANAVERAL, Fla. --- Under a waning moon (upper right) at Cape Canaveral Air Force Station, the Delta II rocket to launch NASA's Gamma-ray Large Area Space Telescope, or GLAST, spacecraft is poised to receive the first of the solid rocket boosters. A series of nine strap-on solid rocket motors will help power the first stage. The GLAST is a powerful space observatory that will explore the Universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. Launch is currently planned for May 16 from Pad 17-B. Photo credit: NASA/Dimitri Gerondidakis

KSC-08pd0855

NASA Image and Video Library

2008-03-27

CAPE CANAVERAL, Fla. --- At Pad 17-B on Cape Canaveral Air Force Station, a solid rocket booster is lifted into the mobile service tower for mating with the Delta II rocket to launch NASA's Gamma-ray Large Area Space Telescope, or GLAST, spacecraft. A series of nine strap-on solid rocket motors will help power the first stage. The GLAST is a powerful space observatory that will explore the Universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. Launch is currently planned for May 16 from Pad 17-B. Photo credit: NASA/Dimitri Gerondidakis

KSC-08pd0851

NASA Image and Video Library

2008-03-27

CAPE CANAVERAL, Fla. --- The first solid rocket motor arrives at Pad 17-B on Cape Canaveral Air Force Station for mating with the Delta II rocket (background) to launch NASA's Gamma-ray Large Area Space Telescope, or GLAST, spacecraft. A series of nine strap-on solid rocket motors will help power the first stage.The GLAST is a powerful space observatory that will explore the Universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. Launch is currently planned for May 16 from Pad 17-B. Photo credit: NASA/Dimitri Gerondidakis

KSC-08pd0847

NASA Image and Video Library

2008-03-27

CAPE CANAVERAL, Fla. --- At Cape Canaveral Air Force Station, the Delta II rocket to launch NASA's Gamma-ray Large Area Space Telescope, or GLAST, spacecraft is poised to receive the first of the solid rocket boosters. A series of nine strap-on solid rocket motors will help power the first stage. The GLAST is a powerful space observatory that will explore the Universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. Launch is currently planned for May 16 from Pad 17-B. Photo credit: NASA/Dimitri Gerondidakis

KSC-08pd0850

NASA Image and Video Library

2008-03-27

CAPE CANAVERAL, Fla. --- At Cape Canaveral Air Force Station, the Delta II rocket to launch NASA's Gamma-ray Large Area Space Telescope, or GLAST, spacecraft is poised to receive the first of the solid rocket boosters. A series of nine strap-on solid rocket motors will help power the first stage. The GLAST is a powerful space observatory that will explore the Universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. Launch is currently planned for May 16 from Pad 17-B. Photo credit: NASA/Dimitri Gerondidakis

KSC-08pd0849

NASA Image and Video Library

2008-03-27

CAPE CANAVERAL, Fla. --- The first solid rocket motor arrives at Pad 17-B on Cape Canaveral Air Force Station for mating with the Delta II rocket to launch NASA's Gamma-ray Large Area Space Telescope, or GLAST, spacecraft. A series of nine strap-on solid rocket motors will help power the first stage. The GLAST is a powerful space observatory that will explore the Universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. Launch is currently planned for May 16 from Pad 17-B. Photo credit: NASA/Dimitri Gerondidakis

KSC-08pd1400

NASA Image and Video Library

2008-05-16

CAPE CANAVERAL, Fla. -- At Astrotech in Titusville, Fla., the payload transportation canister is lowered over the GLAST spacecraft for installation. The spacecraft will be moved to pad 17-B at Cape Canaveral Air Force Station. At the pad, NASA's Gamma-Ray Large Area Space Telescope will be lifted into the mobile service tower and encapsulated in the fairing for launch. GLAST is a powerful space observatory that will explore the Universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. The launch date is targeted no earlier than June 3. Photo credit: NASA/Kim Shiflett

KSC-08pd0952

NASA Image and Video Library

2008-04-15

CAPE CANAVERAL, Fla. -- In the Astrotech payload processing facility near NASA's Kennedy Space Center, General Dynamics technicians, sitting beneath the Gamma-ray Large Area Space Telescope, or GLAST, carefully position a high-gain antenna under the spacecraft as they prepare to install it on the spacecraft. The GLAST is a powerful space observatory that will explore the universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. Launch is currently planned in a window between 11:45 a.m. and 1:40 p.m. EDT May 16. Photo credit: NASA/Kim Shiflett

KSC-08pd1407

NASA Image and Video Library

2008-05-16

CAPE CANAVERAL, Fla. -- At Astrotech in Titusville, Fla., technicians secure the GLAST spacecraft, inside its payload transportation canister, to the transporter for transfer to pad 17-B at Cape Canaveral Air Force Station. At the pad, NASA's Gamma-Ray Large Area Space Telescope will be lifted into the mobile service tower and encapsulated in the fairing for launch. GLAST is a powerful space observatory that will explore the Universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. The launch date is targeted no earlier than June 3. Photo credit: NASA/Kim Shiflett

KSC-08pd0169

NASA Image and Video Library

2008-02-06

KENNEDY SPACE CENTER, FLA. -- In Hangar M on Cape Canaveral Air Force Station in Florida, the United Launch Alliance Delta II first stage is revealed after the cover was removed from the truck trailer that delivered it. The Delta rocket will be used to launch the Gamma-Ray Large Area Space Telescope, or GLAST, in May from Launch Pad 17-B on CCAFS. The GLAST is a powerful space observatory that will explore the Universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. Photo credit: NASA/George Shelton

KSC-08pd1408

NASA Image and Video Library

2008-05-16

CAPE CANAVERAL, Fla. -- At Astrotech in Titusville, Fla., technicians secure the GLAST spacecraft, inside its payload transportation canister, to the transporter for transfer to pad 17-B at Cape Canaveral Air Force Station. At the pad, NASA's Gamma-Ray Large Area Space Telescope will be lifted into the mobile service tower and encapsulated in the fairing for launch. GLAST is a powerful space observatory that will explore the Universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. The launch date is targeted no earlier than June 3. Photo credit: NASA/Kim Shiflett

KSC-08pd0171

NASA Image and Video Library

2008-02-06

KENNEDY SPACE CENTER, FLA. -- In Hangar M on Cape Canaveral Air Force Station in Florida, the United Launch Alliance Delta II first stage is revealed after the cover was removed from the truck that delivered it. The Delta rocket will be used to launch the Gamma-Ray Large Area Space Telescope, or GLAST, in May from Launch Pad 17-B on CCAFS. The GLAST is a powerful space observatory that will explore the Universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. Photo credit: NASA/George Shelton

Prediction of Spacecraft Vibration using Acceleration and Force Envelopes

NASA Technical Reports Server (NTRS)

Gordon, Scott; Kaufman, Daniel; Kern, Dennis; Scharton, Terry

2009-01-01

The base forces in the GLAST X- and Z-axis sine vibration tests were similar to those derived using generic inputs (from users guide and handbook), but the base forces in the sine test were generally greater than the flight data. Basedrive analyses using envelopes of flight acceleration data provided more accurate predictions of the base force than generic inputs, and as expected, using envelopes of both the flight acceleration and force provided even more accurate predictions The GLAST spacecraft interface accelerations and forces measured during the MECO transient were relatively low in the 60 to 150 Hz regime. One may expect the flight forces measured at the base of various spacecraft to be more dependent on the mass, frequencies, etc. of the spacecraft than are the corresponding interface acceleration data, which may depend more on the launch vehicle configuration.

The Disk-Jet Connection in Radio-Loud AGN: The X-Ray Perspective

NASA Technical Reports Server (NTRS)

Sambruna, Rita

2008-01-01

Unification schemes assume that radio-loud active galactic nuclei (AGN) contain an accretion disk and a relativistic jet perpendicular to the disk, and an obscuring molecular torus. The jet dominance decreases with larger viewing angles from blazars to Broad-Line and Narrow-Line Radio Galaxies. A fundamental question is how accretion and ejecta are related. The X-rays provide a convenient window to study these issues, as they originate in the innermost nuclear regions and penetrate large obscuring columns. I review the data, using observations by Chandra but also from other currently operating high-energy experiments. Synergy with the upcoming GLAST mission will also be highlighted.

The Gamma-Ray Albedo of the Moon

DOE Office of Scientific and Technical Information (OSTI.GOV)

Moskalenko, I.V.; /Stanford U., HEPL /KIPAC, Menlo Park; Porter, T.A.

2008-03-25

We use the GEANT4 Monte Carlo framework to calculate the {gamma}-ray albedo of the Moon due to interactions of cosmic ray (CR) nuclei with moon rock. Our calculation of the albedo spectrum agrees with the EGRET data. We show that the spectrum of {gamma}-rays from the Moon is very steep with an effective cutoff around 3-4 GeV (600 MeV for the inner part of the Moon disk) and exhibits a narrow pion-decay line at 67.5 MeV, perhaps unique in astrophysics. Apart from other astrophysical sources, the albedo spectrum of the Moon is well understood, including its absolute normalization; this makesmore » it a useful 'standard candle' for {gamma}-ray telescopes. The steep albedo spectrum also provides a unique opportunity for energy calibration of {gamma}-ray telescopes, such as the forthcoming Gamma Ray Large Area Space Telescope (GLAST). Since the albedo flux depends on the incident CR spectrum which changes over the solar cycle, it is possible to monitor the CR spectrum using the albedo {gamma}-ray flux. Simultaneous measurements of CR proton and helium spectra by the Payload for Antimatter-Matter Exploration and Light-nuclei Astrophysics (PAMELA), and observations of the albedo {gamma}-rays by the GLAST Large Area Telescope (LAT), can be used to test the model predictions and will enable the LAT to monitor the CR spectrum near the Earth beyond the lifetime of the PAMELA.« less

The Gamma-ray Albedo of the Moon

DOE Office of Scientific and Technical Information (OSTI.GOV)

Moskalenko, Igor V.; /Stanford U., HEPL; Porter, Troy A.

2007-09-28

We use the GEANT4 Monte Carlo framework to calculate the {gamma}-ray albedo of the Moon due to interactions of cosmic ray (CR) nuclei with moon rock. Our calculation of the albedo spectrum agrees with the EGRET data. We show that the spectrum of {gamma}-rays from the Moon is very steep with an effective cutoff around 3-4 GeV (600 MeV for the inner part of the Moon disk) and exhibits a narrow pion-decay line at 67.5 MeV, perhaps unique in astrophysics. Apart from other astrophysical sources, the albedo spectrum of the Moon is well understood, including its absolute normalization; this makesmore » it a useful 'standard candle' for {gamma}-ray telescopes. The steep albedo spectrum also provides a unique opportunity for energy calibration of {gamma}-ray telescopes, such as the forthcoming Gamma Ray Large Area Space Telescope (GLAST). Since the albedo flux depends on the incident CR spectrum which changes over the solar cycle, it is possible to monitor the CR spectrum using the albedo {gamma}-ray flux. Simultaneous measurements of CR proton and helium spectra by the Payload for Antimatter-Matter Exploration and Light-nuclei Astrophysics (PAMELA), and observations of the albedo {gamma}-rays by the GLAST Large Area Telescope (LAT), can be used to test the model predictions and will enable the LAT to monitor the CR spectrum near the Earth beyond the lifetime of the PAMELA.« less

KSC-08pd0854

NASA Image and Video Library

2008-03-27

CAPE CANAVERAL, Fla. --- At Pad 17-B on Cape Canaveral Air Force Station, a solid rocket booster is ready to be lifted into the mobile service tower for mating with the Delta II rocket to launch NASA's Gamma-ray Large Area Space Telescope, or GLAST, spacecraft. A series of nine strap-on solid rocket motors will help power the first stage. The GLAST is a powerful space observatory that will explore the Universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. Launch is currently planned for May 16 from Pad 17-B. Photo credit: NASA/Dimitri Gerondidakis

KSC-08pd0857

NASA Image and Video Library

2008-03-27

CAPE CANAVERAL, Fla. --- At Pad 17-B on Cape Canaveral Air Force Station, technicians check the electronics on a solid rocket booster to be lifted into the mobile service tower for mating with the Delta II rocket that will launch NASA's Gamma-ray Large Area Space Telescope, or GLAST, spacecraft. A series of nine strap-on solid rocket motors will help power the first stage. The GLAST is a powerful space observatory that will explore the Universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. Launch is currently planned for May 16 from Pad 17-B. Photo credit: NASA/Dimitri Gerondidakis

KSC-08pd0859

NASA Image and Video Library

2008-03-27

CAPE CANAVERAL, Fla. --- At Pad 17-B on Cape Canaveral Air Force Station, a second solid rocket booster joins the first booster lifted into the mobile service tower for mating with the Delta II rocket (background) that will launch NASA's Gamma-ray Large Area Space Telescope, or GLAST, spacecraft. A series of nine strap-on solid rocket motors will help power the first stage. The GLAST is a powerful space observatory that will explore the Universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. Launch is currently planned for May 16 from Pad 17-B. Photo credit: NASA/Dimitri Gerondidakis

KSC-08pd0856

NASA Image and Video Library

2008-03-27

CAPE CANAVERAL, Fla. --- At Pad 17-B on Cape Canaveral Air Force Station, a second solid rocket booster is raised from its transporter. The booster will join the first booster lifted into the mobile service tower for mating with the Delta II rocket to launch NASA's Gamma-ray Large Area Space Telescope, or GLAST, spacecraft. A series of nine strap-on solid rocket motors will help power the first stage. The GLAST is a powerful space observatory that will explore the Universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. Launch is currently planned for May 16 from Pad 17-B. Photo credit: NASA/Dimitri Gerondidakis

KSC-08pd0853

NASA Image and Video Library

2008-03-27

CAPE CANAVERAL, Fla. --- At Pad 17-B on Cape Canaveral Air Force Station, a solid rocket booster is raised to a vertical position for lifting into the mobile service tower. There it will be mated with the Delta II rocket to launch NASA's Gamma-ray Large Area Space Telescope, or GLAST, spacecraft. A series of nine strap-on solid rocket motors will help power the first stage. The GLAST is a powerful space observatory that will explore the Universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. Launch is currently planned for May 16 from Pad 17-B. Photo credit: NASA/Dimitri Gerondidakis

KSC-08pd0858

NASA Image and Video Library

2008-03-27

CAPE CANAVERAL, Fla. --- At Pad 17-B on Cape Canaveral Air Force Station, a second solid rocket booster joins the first booster lifted into the mobile service tower for mating with the Delta II rocket that will launch NASA's Gamma-ray Large Area Space Telescope, or GLAST, spacecraft. A series of nine strap-on solid rocket motors will help power the first stage. The GLAST is a powerful space observatory that will explore the Universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. Launch is currently planned for May 16 from Pad 17-B. Photo credit: NASA/Dimitri Gerondidakis

KSC-08pd0852

NASA Image and Video Library

2008-03-27

CAPE CANAVERAL, Fla. --- At Pad 17-B on Cape Canaveral Air Force Station, a solid rocket booster is raised from its transporter. The booster will be lifted into the mobile service tower for mating with the Delta II rocket to launch NASA's Gamma-ray Large Area Space Telescope, or GLAST, spacecraft. A series of nine strap-on solid rocket motors will help power the first stage. The GLAST is a powerful space observatory that will explore the Universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. Launch is currently planned for May 16 from Pad 17-B. Photo credit: NASA/Dimitri Gerondidakis

KSC-08pd1397

NASA Image and Video Library

2008-05-16

CAPE CANAVERAL, Fla. -- At Astrotech in Titusville, Fla., the payload transportation canister is lifted so it can be installed over the GLAST spacecraft, behind it. After installation, the spacecraft will be moved to pad 17-B at Cape Canaveral Air Force Station. At the pad, NASA's Gamma-Ray Large Area Space Telescope will be lifted into the mobile service tower and encapsulated in the fairing for launch. GLAST is a powerful space observatory that will explore the Universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. The launch date is targeted no earlier than June 3. Photo credit: NASA/Kim Shiflett

KSC-08pd1398

NASA Image and Video Library

2008-05-16

CAPE CANAVERAL, Fla. -- At Astrotech in Titusville, Fla., the payload transportation canister is lifted so it can be installed over the GLAST spacecraft, behind it. After installation, the spacecraft will be moved to pad 17-B at Cape Canaveral Air Force Station. At the pad, NASA's Gamma-Ray Large Area Space Telescope will be lifted into the mobile service tower and encapsulated in the fairing for launch. GLAST is a powerful space observatory that will explore the Universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. The launch date is targeted no earlier than June 3. Photo credit: NASA/Kim Shiflett

KSC-08pd0902

NASA Image and Video Library

2008-04-03

CAPE CANAVERAL, Fla. --- On Pad 17-B at Cape Canaveral Air Force Station in Florida, United Launch Alliance technicians check the list of activities completed on the mating of the nine solid rocket boosters to the Delta II rocket for the launch of NASA's Gamma-ray Large Area Space Telescope, or GLAST. The GLAST is a powerful space observatory that will explore the Universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. Launch is currently planned in a window between 11:45 a.m. and 1:40 p.m. May 16. Photo credit: NASA/Troy Cryder

KSC-08pd1432

NASA Image and Video Library

2008-05-27

CAPE CANAVERAL, Fla. -- Inside the mobile service tower on Launch Pad 17-B at Cape Canaveral Air Force Station, NASA's Gamma-Ray Large Area Space Telescope, or GLAST, is ready for encapsulation in the payload fairing. The fairing is a molded structure that fits flush with the outside surface of the Delta II upper stage booster and forms an aerodynamically smooth nose cone, protecting the spacecraft during launch and ascent. GLAST is a powerful space observatory that will explore the Universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. The launch date is targeted no earlier than June 3. Photo credit: NASA/Jim Grossmann

KSC-08pd1639

NASA Image and Video Library

2008-06-11

CAPE CANAVERAL, Fla. -- Smoke is generated at liftoff of the Delta II rocket with NASA's Gamma-Ray Large Area Space Telescope , or GLAST, aboard from Cape Canaveral Air Force Station's Launch Pad 17-B. In the background can be seen the blue Atlantic Ocean between the beach and the cloud-filled sky. Liftoff was at 12:05 p.m. EDT. GLAST is a powerful space observatory that will explore the universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. Launch is scheduled for 11:45 a.m. June 11. Photo credit: NASA/Jerry Cannon, Robert Murray

KSC-08pd1402

NASA Image and Video Library

2008-05-16

CAPE CANAVERAL, Fla. -- At Astrotech in Titusville, Fla., technicians check the alignment of the payload transportation canister as it is lowered over the GLAST spacecraft for installation. The spacecraft will be moved to pad 17-B at Cape Canaveral Air Force Station. At the pad, NASA's Gamma-Ray Large Area Space Telescope will be lifted into the mobile service tower and encapsulated in the fairing for launch. GLAST is a powerful space observatory that will explore the Universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. The launch date is targeted no earlier than June 3. Photo credit: NASA/Kim Shiflett

KSC-08pd0168A

NASA Image and Video Library

2008-02-06

KENNEDY SPACE CENTER, FLA. -- Workers in Hangar M on Cape Canaveral Air Force Station in Florida get ready to remove the lid on the truck trailer to offload the United Launch Alliance Delta II first stage. Visible is the engine of the first stage. The Delta rocket will be used to launch the Gamma-Ray Large Area Space Telescope, or GLAST, in May from Launch Pad 17-B on CCAFS. The GLAST is a powerful space observatory that will explore the Universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. Photo credit: NASA/George Shelton

KSC-08pd1404

NASA Image and Video Library

2008-05-16

CAPE CANAVERAL, Fla. -- At Astrotech in Titusville, Fla., the GLAST spacecraft, inside its payload transportation canister, is lifted from its stand. It will be moved to a transporter for transfer to pad 17-B at Cape Canaveral Air Force Station. At the pad, NASA's Gamma-Ray Large Area Space Telescope will be lifted into the mobile service tower and encapsulated in the fairing for launch. GLAST is a powerful space observatory that will explore the Universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. The launch date is targeted no earlier than June 3. Photo credit: NASA/Kim Shiflett

KSC-08pd1433

NASA Image and Video Library

2008-05-27

CAPE CANAVERAL, Fla. -- Inside the mobile service tower on Launch Pad 17-B at Cape Canaveral Air Force Station, NASA's Gamma-Ray Large Area Space Telescope, or GLAST, is ready for encapsulation in the payload fairing. The fairing is a molded structure that fits flush with the outside surface of the Delta II upper stage booster and forms an aerodynamically smooth nose cone, protecting the spacecraft during launch and ascent. GLAST is a powerful space observatory that will explore the Universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. The launch date is targeted no earlier than June 3. Photo credit: NASA/Jim Grossmann

KSC-08pd1399

NASA Image and Video Library

2008-05-16

CAPE CANAVERAL, Fla. -- At Astrotech in Titusville, Fla., technicians ensure the payload transportation canister is properly placed to lower over the GLAST spacecraft. After installation, the spacecraft will be moved to pad 17-B at Cape Canaveral Air Force Station. At the pad, NASA's Gamma-Ray Large Area Space Telescope will be lifted into the mobile service tower and encapsulated in the fairing for launch. GLAST is a powerful space observatory that will explore the Universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. The launch date is targeted no earlier than June 3. Photo credit: NASA/Kim Shiflett

KSC-08pd1406

NASA Image and Video Library

2008-05-16

CAPE CANAVERAL, Fla. -- At Astrotech in Titusville, Fla., an overhead crane moves the GLAST spacecraft, inside its payload transportation canister, to the waiting transporter for transfer to pad 17-B at Cape Canaveral Air Force Station. At the pad, NASA's Gamma-Ray Large Area Space Telescope will be lifted into the mobile service tower and encapsulated in the fairing for launch. GLAST is a powerful space observatory that will explore the Universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. The launch date is targeted no earlier than June 3. Photo credit: NASA/Kim Shiflett

KSC-08pd1396

NASA Image and Video Library

2008-05-16

CAPE CANAVERAL, Fla. -- At Astrotech in Titusville, Fla., the wrapped GLAST spacecraft, at right, is ready to be installed into the payload transportation canister, at left. After installation, the spacecraft will be moved to pad 17-B at Cape Canaveral Air Force Station. At the pad, NASA's Gamma-Ray Large Area Space Telescope will be lifted into the mobile service tower and encapsulated in the fairing for launch. GLAST is a powerful space observatory that will explore the Universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. The launch date is targeted no earlier than June 3. Photo credit: NASA/Kim Shiflett

KSC-08pd1638

NASA Image and Video Library

2008-06-11

CAPE CANAVERAL, Fla. --Smoke rises to obscure the Delta II rocket with NASA's Gamma-Ray Large Area Space Telescope , or GLAST, aboard as it launches from Cape Canaveral Air Force Station's Launch Pad 17-B. In the background can be seen the blue Atlantic Ocean between the beach and the cloud-filled sky. Liftoff was at 12:05 p.m. EDT. GLAST is a powerful space observatory that will explore the universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. Launch is scheduled for 11:45 a.m. June 11. Photo credit: NASA/Jerry Cannon, Robert Murray

KSC-08pd1403

NASA Image and Video Library

2008-05-16

CAPE CANAVERAL, Fla. -- At Astrotech in Titusville, Fla., technicians unfurl the bottom portion of the white cover over the payload transportation canister installed around the GLAST spacecraft. All will be moved to pad 17-B at Cape Canaveral Air Force Station. At the pad, NASA's Gamma-Ray Large Area Space Telescope will be lifted into the mobile service tower and encapsulated in the fairing for launch. GLAST is a powerful space observatory that will explore the Universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. The launch date is targeted no earlier than June 3. Photo credit: NASA/Kim Shiflett

KSC-08pd1637

NASA Image and Video Library

2008-06-11

CAPE CANAVERAL, Fla. --On Cape Canaveral Air Force Station's Launch Pad 17-B, flame and smoke mark the launch of the Delta II rocket with NASA's Gamma-Ray Large Area Space Telescope , or GLAST, aboard. In the background can be seen the blue Atlantic Ocean between the beach and the cloud-filled sky. Liftoff was at 12:05 p.m. EDT. GLAST is a powerful space observatory that will explore the universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. Launch is scheduled for 11:45 a.m. June 11. Photo credit: NASA/Jerry Cannon, Robert Murray

Space instrumentation for gamma-ray astronomy

NASA Astrophysics Data System (ADS)

Teegarden, B. J.

1999-02-01

The decade of the 1990s has witnessed a renaissance in the field of gamma-ray astronomy. The seminal event was the launch of the Compton Gamma-Ray Observatory (CGRO) in April 1991. There have been a flood of major discoveries from CGRO including breakthroughs in gamma-ray bursts, annihilation radiation, and blazars. The Italian SAX satellite was launched in April 1996. Although not primarily a gamma-ray mission, it has added a new dimension to our understanding of gamma-ray bursts. Along with these new discoveries a firm groundwork has been laid for missions and new technology development that should maintain a healthy and vigorous field throughout most of the next decade. These include the ESA INTEGRAL mission (INTErnational Gamma-Ray Astrophysics Laboratory, to be launched in mid-2001) and the NASA GLAST mission (Gamma-Ray Large Area Space Telescope) with a likely launch in the middle of the next decade. These two missions will extend the observational capabilities well beyond those of CGRO. New technologies (to gamma-ray astronomy), such as cooled germanium detectors, silicon strip detectors, and CdTe detectors are planned for these new missions. Additional promising new technologies such as CdZnTe strip detectors, scintillator fibers, and a gamma-ray lens for future gamma-ray astronomy missions are under development in laboratories around the world.

The Cosmic Ray Electron Excess

NASA Technical Reports Server (NTRS)

Chang, J.; Adams, J. H.; Ahn, H. S.; Bashindzhagyan, G. L.; Christl, M.; Ganel, O.; Guzik, T. G.; Isbert, J.; Kim, K. C.; Kuznetsov, E. N.;

The Gamma-Ray Imager GRI

NASA Astrophysics Data System (ADS)

Wunderer, Cornelia B.; GRI Collaboration

2008-03-01

Observations of the gamma-ray sky reveal the most powerful sources and the most violent events in the Universe. While at lower wavebands the observed emission is generally dominated by thermal processes, the gamma-ray sky provides us with a view on the non-thermal Universe. Here particles are accelerated to extreme relativistic energies by mechanisms which are still poorly understood, and nuclear reactions are synthesizing the basic constituents of our world. Cosmic accelerators and cosmic explosions are major science themes that are addressed in the gamma-ray regime. ESA's INTEGRAL observatory currently provides the astronomical community with a unique tool to investigate the sky up to MeV energies and hundreds of sources, new classes of objects, extraordinary views of antimatter annihilation in our Galaxy, and fingerprints of recent nucleosynthesis processes have been discovered. NASA's GLAST mission will similarly take the next step in surveying the high-energy ( GeV) sky, and NuSTAR will pioneer focusing observations at hard X-ray energies (to 80 keV). There will be clearly a growing need to perform deeper, more focused investigations of gamma-ray sources in the 100-keV to MeV regime. Recent technological advances in the domain of gamma-ray focusing using Laue diffraction and multilayer-coated mirror techniques have paved the way towards a gamma-ray mission, providing major improvements compared to past missions regarding sensitivity and angular resolution. Such a future Gamma-Ray Imager will allow the study of particle acceleration processes and explosion physics in unprecedented detail, providing essential clues on the innermost nature of the most violent and most energetic processes in the Universe.

Energy spectrum of secondary protons above the atmosphere measured by the instruments NINA and NINA-2

NASA Astrophysics Data System (ADS)

Bidoli, V.; Casolino, M.; de Pascale, M.; Furano, G.; Iannucci, A.; Morselli, A.; Picozza, P.; Sparvoli, R.; Bakaldin, A.; Galper, A.; Koldashov, S.; Korotkov, M.; Leonov, A.; Mikhailov, V.; Voronov, S.; Boezio, M.; Bonvicini, V.; Vacchi, A.; Zampa, G.; Zampa, N.; Ambriola, M.; Cafagna, F.; Circella, M.; de Marzo, C.; Adriani, O.; Papini, P.; Spillantini, P.; Straulino, S.; Vannuccini, E.; Ricci, M.; Castellini, G.

2002-10-01

In this paper we report on the energy spectrum of protons of albedo origin measured by the instruments NINA and NINA-2 at different geomagnetic locations, and the behaviour of the proton flux as a function of altitude out of the South Atlantic Anomaly. The instrument NINA was used on board the satellite Resurs-01-N4 between 1998 and 1999, at an altitude of about 830 km. The NINA-2 apparatus, on board the satellite MITA, was put into orbit in July 2000, at an altitude of about 450 km. A detailed understanding of the fluxes of charged particles in near Earth orbit is important to reach an accurate theoretical description of the Earth’s magnetic field, but also as input for the calculation of the back-ground for scientific instruments aboard satellites, like the future AGILE and GLAST g

Anti-Coincidence Detector for GLAST

NASA Technical Reports Server (NTRS)

Moiseev, Alexander A.; Hartman, R. C.; Johnson, Thomas E.; Ormes, Jonathan F.; Thompson, D. J.

2004-01-01

The Anti-Coincidence Detector (ACD) is the outermost detector layer in the GLAST Large Area Telescope (LAT), surrounding the top and sides of the tracker. The purpose of the ACD is to detect and veto incident cosmic ray charged particles, which outnumber cosmic gamma rays by 3-5 orders of magnitude. The challenge in ACD design is that it has to have high (0.9997) detection efficiency for relativistic charged particles, but must have low sensitivity to backsplash photons. These are products of high energy interactions in the LAT calorimeter, and can cause a veto signal in the ACD resulting in degradation of the LAT efficiency for high energy (>10 GeV) gamma-rays. The ACD requirement is that backsplash shall not reduce the LAT sensitivity by more than 20% for gamma rays of 300 GeV. To solve this problem, the ACD is divided into 89 scintillating tiles, with wave-length shifting fiber readout. The detector design and its characteristics are given in this paper.

KSC-08pd0871

NASA Image and Video Library

2008-03-27

CAPE CANAVERAL, Fla. --- On Pad 17-B on Cape Canaveral Air Force Station, the Delta II rocket, at right, that will launch NASA's Gamma-ray Large Area Space Telescope, or GLAST, spacecraft is poised to receive the solid rocket boosters in the mobile service tower, at left. A series of nine strap-on solid rocket motors will help power the first stage. Because the Delta rocket is configured as a Delta II 7920 Heavy, the boosters are larger than those used on the standard configuration. The GLAST is a powerful space observatory that will explore the Universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. Launch is currently planned for May 16 from Pad 17-B. Photo credit: NASA/Jim Grossmann

KSC-08pd0869

NASA Image and Video Library

2008-03-27

CAPE CANAVERAL, Fla. --- On Pad 17-B on Cape Canaveral Air Force Station, three solid rocket boosters are in the mobile service tower. They will be mated with the Delta II rocket, at left, that will launch NASA's Gamma-ray Large Area Space Telescope, or GLAST, spacecraft. A series of nine strap-on solid rocket motors will help power the first stage. Because the Delta rocket is configured as a Delta II 7920 Heavy, the boosters are larger than those used on the standard configuration. The GLAST is a powerful space observatory that will explore the Universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. Launch is currently planned for May 16 from Pad 17-B. Photo credit: NASA/Jim Grossmann

KSC-08pd0868

NASA Image and Video Library

2008-03-27

CAPE CANAVERAL, Fla. --- On Pad 17-B on Cape Canaveral Air Force Station, three solid rocket boosters are in the mobile service tower. They will be mated with the Delta II rocket, at left, that will launch NASA's Gamma-ray Large Area Space Telescope, or GLAST, spacecraft. A series of nine strap-on solid rocket motors will help power the first stage. Because the Delta rocket is configured as a Delta II 7920 Heavy, the boosters are larger than those used on the standard configuration. The GLAST is a powerful space observatory that will explore the Universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. Launch is currently planned for May 16 from Pad 17-B. Photo credit: NASA/Jim Grossmann

KSC-08pd0860

NASA Image and Video Library

2008-03-27

CAPE CANAVERAL, Fla. --- At Pad 17-B on Cape Canaveral Air Force Station, a second solid rocket booster joins the first booster lifted into the mobile service tower for mating with the Delta II rocket that will launch NASA's Gamma-ray Large Area Space Telescope, or GLAST, spacecraft. A series of nine strap-on solid rocket motors will help power the first stage. Because the Delta rocket is configured as a Delta II 7920 Heavy, the boosters are larger than those used on the standard configuration. The GLAST is a powerful space observatory that will explore the Universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. Launch is currently planned for May 16 from Pad 17-B. Photo credit: NASA/Jim Grossmann

KSC-08pd0861

NASA Image and Video Library

2008-03-27

CAPE CANAVERAL, Fla. --- A third solid rocket booster arrives on Pad 17-B on Cape Canaveral Air Force Station for mating with the Delta II rocket that will launch NASA's Gamma-ray Large Area Space Telescope, or GLAST, spacecraft. A series of nine strap-on solid rocket motors will help power the first stage. Because the Delta rocket is configured as a Delta II 7920 Heavy, the boosters are larger than those used on the standard configuration. The GLAST is a powerful space observatory that will explore the Universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. Launch is currently planned for May 16 from Pad 17-B. Photo credit: NASA/Jim Grossmann

KSC-08pd0867

NASA Image and Video Library

2008-03-27

CAPE CANAVERAL, Fla. --- On Pad 17-B on Cape Canaveral Air Force Station, the third solid rocket booster joins two others in the mobile service tower. They will be mated with the Delta II rocket that will launch NASA's Gamma-ray Large Area Space Telescope, or GLAST, spacecraft. A series of nine strap-on solid rocket motors will help power the first stage. Because the Delta rocket is configured as a Delta II 7920 Heavy, the boosters are larger than those used on the standard configuration. The GLAST is a powerful space observatory that will explore the Universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. Launch is currently planned for May 16 from Pad 17-B. Photo credit: NASA/Jim Grossmann

KSC-08pd0870

NASA Image and Video Library

2008-03-27

CAPE CANAVERAL, Fla. --- On Pad 17-B on Cape Canaveral Air Force Station, the third solid rocket booster joins two others in the mobile service tower. They will be mated with the Delta II rocket that will launch NASA's Gamma-ray Large Area Space Telescope, or GLAST, spacecraft. A series of nine strap-on solid rocket motors will help power the first stage. Because the Delta rocket is configured as a Delta II 7920 Heavy, the boosters are larger than those used on the standard configuration. The GLAST is a powerful space observatory that will explore the Universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. Launch is currently planned for May 16 from Pad 17-B. Photo credit: NASA/Jim Grossmann

Simultaneous Processing of Visible and Long-Wave Infrared Satellite Imagery

DTIC Science & Technology

2015-10-19

Telescope, formerly the Gamma-ray Large Area Telescope (GLAST), and the Hubble Space Telescope (HST). The visible data was processed with a multi-frame...prevalent in the Hubble pass where the panels were already close to the background values. These results are promising; the dimmer features of the object

Blazar Gamma-Rays, Shock Acceleration, and the Extragalactic Background Light

NASA Technical Reports Server (NTRS)

Stecker, Floyd W.; Baring, Matthew G.; Summerlin, Errol J.

2007-01-01

The observed spectra of blazars, their intrinsic emission, and the underlying populations of radiating particles are intimately related. The use of these sources as probes of the extragalactic infrared background, a prospect propelled by recent advances in TeV-band telescopes, soon to be augmented by observations by NASA's upcoming Gamma-Ray Large Area Space Telescope (GLAST), has been a topic of great recent interest. Here, it is demonstrated that if particles in blazar jets are accelerated at relativistic shocks, then GAMMA-ray spectra with indices less than 1.5 can be produced. This, in turn, loosens the upper limits on the near infrared extragalactic background radiation previously proposed. We also show evidence hinting that TeV blazars with flatter spectra have higher intrinsic TeV GAMMA-ray luminosities and we indicate that there may be a correlation of flatness and luminosity with redshift.

High-Energy Emission From the Polar Cap and Slot Gap

NASA Technical Reports Server (NTRS)

Harding, Alice K.

2006-01-01

Thirty-five years after the discovery of rotation-powered pulsars, we still do not understand the fundamentals of their pulsed emission at any wavelength. I will review the latest developments in understanding the high-energy emission of rotation-powered pulsars, with particular emphasis on the polar cap and slot gap models. Special and general relativistic effects play important roles in pulsar emission, from inertial frame-dragging near the stellar surface to aberration, time-of-flight and retardation of the magnetic field near the light cylinder. Understanding how these effects determine what we observe at different wavelengths is critical to unraveling the emission physics. I will discuss how the next generation of gamma-ray detectors, AGILE and GLAST, will test prediction of these models.

KSC-08pd0863

NASA Image and Video Library

2008-03-27

CAPE CANAVERAL, Fla. --- On Pad 17-B on Cape Canaveral Air Force Station, a worker attaches the crane to a solid rocket booster. The crane will raise the booster to a vertical position. When it has been raised, the booster will be lifted into the mobile service tower for mating with the Delta II rocket that will launch NASA's Gamma-ray Large Area Space Telescope, or GLAST, spacecraft. A series of nine strap-on solid rocket motors will help power the first stage. Because the Delta rocket is configured as a Delta II 7920 Heavy, the boosters are larger than those used on the standard configuration. The GLAST is a powerful space observatory that will explore the Universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. Launch is currently planned for May 16 from Pad 17-B. Photo credit: NASA/Jim Grossmann

KSC-08pd0865

NASA Image and Video Library

2008-03-27

CAPE CANAVERAL, Fla. --- On Pad 17-B on Cape Canaveral Air Force Station, the solid rocket booster is raised from its transporter toward a vertical position. When it has been raised, the booster will be lifted into the mobile service tower for mating with the Delta II rocket that will launch NASA's Gamma-ray Large Area Space Telescope, or GLAST, spacecraft. Two other boosters are already in place. A series of nine strap-on solid rocket motors will help power the first stage. Because the Delta rocket is configured as a Delta II 7920 Heavy, the boosters are larger than those used on the standard configuration. The GLAST is a powerful space observatory that will explore the Universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. Launch is currently planned for May 16 from Pad 17-B. Photo credit: NASA/Jim Grossmann

KSC-08pd0872

NASA Image and Video Library

2008-03-27

CAPE CANAVERAL, Fla. --- On Pad 17-B on Cape Canaveral Air Force Station, the mobile service tower at left approaches the Delta II rocket at right. The solid rocket boosters in the tower will be mated with the rocket, which will launch NASA's Gamma-ray Large Area Space Telescope, or GLAST, spacecraft. A series of nine strap-on solid rocket motors will be mated with the rocket to help power the first stage. Because the Delta rocket is configured as a Delta II 7920 Heavy, the boosters are larger than those used on the standard configuration. The GLAST is a powerful space observatory that will explore the Universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. Launch is currently planned for May 16 from Pad 17-B. Photo credit: NASA/Jim Grossmann

KSC-08pd0873

NASA Image and Video Library

2008-03-27

CAPE CANAVERAL, Fla. --- On Pad 17-B on Cape Canaveral Air Force Station, the mobile service tower at left approaches the Delta II rocket at right. The solid rocket boosters in the tower will be mated with the rocket, which will launch NASA's Gamma-ray Large Area Space Telescope, or GLAST, spacecraft. A series of nine strap-on solid rocket motors will be mated with the rocket to help power the first stage. Because the Delta rocket is configured as a Delta II 7920 Heavy, the boosters are larger than those used on the standard configuration. The GLAST is a powerful space observatory that will explore the Universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. Launch is currently planned for May 16 from Pad 17-B. Photo credit: NASA/Jim Grossmann

KSC-08pd0864

NASA Image and Video Library

2008-03-27

CAPE CANAVERAL, Fla. --- On Pad 17-B on Cape Canaveral Air Force Station, the solid rocket booster is raised from its transporter toward a vertical position. When it has been raised, the booster will be lifted into the mobile service tower for mating with the Delta II rocket that will launch NASA's Gamma-ray Large Area Space Telescope, or GLAST, spacecraft. Two other boosters are already in place. A series of nine strap-on solid rocket motors will help power the first stage. Because the Delta rocket is configured as a Delta II 7920 Heavy, the boosters are larger than those used on the standard configuration. The GLAST is a powerful space observatory that will explore the Universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. Launch is currently planned for May 16 from Pad 17-B. Photo credit: NASA/Jim Grossmann

KSC-08pd0866

NASA Image and Video Library

2008-03-27

CAPE CANAVERAL, Fla. --- On Pad 17-B on Cape Canaveral Air Force Station, the third solid rocket booster is lifted into the mobile service tower for mating with the Delta II rocket that will launch NASA's Gamma-ray Large Area Space Telescope, or GLAST, spacecraft. It joins the first two boosters already in place. A series of nine strap-on solid rocket motors will help power the first stage. Because the Delta rocket is configured as a Delta II 7920 Heavy, the boosters are larger than those used on the standard configuration. The GLAST is a powerful space observatory that will explore the Universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. Launch is currently planned for May 16 from Pad 17-B. Photo credit: NASA/Jim Grossmann

KSC-08pd0862

NASA Image and Video Library

2008-03-27

CAPE CANAVERAL, Fla. --- On Pad 17-B on Cape Canaveral Air Force Station, workers prepare to raise the solid rocket booster to a vertical position. When it has been raised, the booster will be lifted into the mobile service tower for mating with the Delta II rocket that will launch NASA's Gamma-ray Large Area Space Telescope, or GLAST, spacecraft. A series of nine strap-on solid rocket motors will help power the first stage. Because the Delta rocket is configured as a Delta II 7920 Heavy, the boosters are larger than those used on the standard configuration. The GLAST is a powerful space observatory that will explore the Universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. Launch is currently planned for May 16 from Pad 17-B. Photo credit: NASA/Jim Grossmann

Significant gamma lines from inert Higgs dark matter.

PubMed

Gustafsson, Michael; Lundström, Erik; Bergström, Lars; Edsjö, Joakim

2007-07-27

One way to unambiguously confirm the existence of particle dark matter and determine its mass would be to detect its annihilation into monochromatic gamma-rays in upcoming telescopes. One of the most minimal models for dark matter is the inert doublet model, obtained by adding another Higgs doublet with no direct coupling to fermions. For a mass between 40 and 80 GeV, the lightest of the new inert Higgs particles can give the correct cosmic abundance of cold dark matter in agreement with current observations. We show that for this scalar dark matter candidate, the annihilation signal of monochromatic gammagamma and Zgamma final states would be exceptionally strong. The energy range and rates for these gamma-ray line signals make them ideal to search for with the soon upcoming GLAST satellite.

Plasticity of Astrocytic Coverage and Glutamate Transporter Expression in Adult Mouse Cortex

PubMed Central

Steiner, Pascal; Hirling, Harald; Welker, Egbert; Knott, Graham W

2006-01-01

Astrocytes play a major role in the removal of glutamate from the extracellular compartment. This clearance limits the glutamate receptor activation and affects the synaptic response. This function of the astrocyte is dependent on its positioning around the synapse, as well as on the level of expression of its high-affinity glutamate transporters, GLT1 and GLAST. Using Western blot analysis and serial section electron microscopy, we studied how a change in sensory activity affected these parameters in the adult cortex. Using mice, we found that 24 h of whisker stimulation elicited a 2-fold increase in the expression of GLT1 and GLAST in the corresponding cortical column of the barrel cortex. This returns to basal levels 4 d after the stimulation was stopped, whereas the expression of the neuronal glutamate transporter EAAC1 remained unaltered throughout. Ultrastructural analysis from the same region showed that sensory stimulation also causes a significant increase in the astrocytic envelopment of excitatory synapses on dendritic spines. We conclude that a period of modified neuronal activity and synaptic release of glutamate leads to an increased astrocytic coverage of the bouton–spine interface and an increase in glutamate transporter expression in astrocytic processes. PMID:17048987

Effects of chronic inhalation of electronic cigarettes containing nicotine on glial glutamate transporters and α-7 nicotinic acetylcholine receptor in female CD-1 mice.

PubMed

Alasmari, Fawaz; Crotty Alexander, Laura E; Nelson, Jessica A; Schiefer, Isaac T; Breen, Ellen; Drummond, Christopher A; Sari, Youssef

2017-07-03

Alteration in glutamate neurotransmission has been found to mediate the development of drug dependence, including nicotine. We and others, through using western blotting, have reported that exposure to drugs of abuse reduced the expression of glutamate transporter-1 (GLT-1) as well as cystine/glutamate antiporter (xCT), which consequently increased extracellular glutamate concentrations in the mesocorticolimbic area. However, our previous studies did not reveal any changes in glutamate/aspartate transporter (GLAST) following exposure to drugs of abuse. In the present study, for the first time, we investigated the effect of chronic exposure to electronic (e)-cigarette vapor containing nicotine, for one hour daily for six months, on GLT-1, xCT, and GLAST expression in frontal cortex (FC), striatum (STR), and hippocampus (HIP) in outbred female CD1 mice. In this study, we also investigated the expression of alpha-7 nicotinic acetylcholine receptor (α-7 nAChR), a major pre-synaptic nicotinic receptor in the glutamatergic neurons, which regulates glutamate release. We found that inhalation of e-cigarette vapor for six months increased α-7 nAChR expression in both FC and STR, but not in the HIP. In addition, chronic e-cigarette exposure reduced GLT-1 expression only in STR. Moreover, e-cigarette vapor inhalation induced downregulation of xCT in both the STR and HIP. We did not find any significant changes in GLAST expression in any brain region. Finally, using liquid chromatography-tandem mass spectrometry (LC-MS/MS) techniques, we detected high concentrations of nicotine and cotinine, a major metabolite of nicotine, in the FC tissues of e-cigarette exposed mice. These data provide novel evidence about the effects of chronic nicotine inhalation on the expression of key glial glutamate transporters as well as α-7 nAChR. Our work may suggest that nicotine exposure via chronic inhalation of e-cigarette vapor may be mediated in part by alterations in the glutamatergic system. Copyright © 2017 Elsevier Inc. All rights reserved.

NRL SSD Research Achievements: 20002010. Volume 5

DTIC Science & Technology

2015-10-30

monochromatic spectral images of the solar corona at unprecedented spatial and spectral resolution, allowing the physical properties of the corona to be...launch, is a tremendous astrophysical mission that is opening up the gamma ray sky. NRL SSD has played leading roles in the development of GLAST...experimentation program to study the atmospheres of the Sun and the Earth, the physics and properties of high-energy space environments, and solar

Refined protocols of tamoxifen injection for inducible DNA recombination in mouse astroglia.

PubMed

Jahn, Hannah M; Kasakow, Carmen V; Helfer, Andreas; Michely, Julian; Verkhratsky, Alexei; Maurer, Hans H; Scheller, Anja; Kirchhoff, Frank

2018-04-12

Inducible DNA recombination of floxed alleles in vivo by liver metabolites of tamoxifen (TAM) is an important tool to study gene functions. Here, we describe protocols for optimal DNA recombination in astrocytes, based on the GLAST-Cre ERT2 /loxP system. In addition, we demonstrate that quantification of genomic recombination allows to determine the proportion of cell types in various brain regions. We analyzed the presence and clearance of TAM and its metabolites (N-desmethyl-tamoxifen, 4-hydroxytamoxifen and endoxifen) in brain and serum of mice by liquid chromatographic-high resolution-tandem mass spectrometry (LC-HR-MS/MS) and assessed optimal injection protocols by quantitative RT-PCR of several floxed target genes (p2ry1, gria1, gabbr1 and Rosa26-tdTomato locus). Maximal recombination could be achieved in cortex and cerebellum by single daily injections for five and three consecutive days, respectively. Furthermore, quantifying the loss of floxed alleles predicted the percentage of GLAST-positive cells (astroglia) per brain region. We found that astrocytes contributed 20 to 30% of the total cell number in cortex, hippocampus, brainstem and optic nerve, while in the cerebellum Bergmann glia, velate astrocytes and white matter astrocytes accounted only for 8% of all cells.

Topical Administration of Somatostatin Prevents Retinal Neurodegeneration in Experimental Diabetes

PubMed Central

Hernández, Cristina; García-Ramírez, Marta; Corraliza, Lidia; Fernández-Carneado, Jimena; Farrera-Sinfreu, Josep; Ponsati, Berta; González-Rodríguez, Águeda; Valverde, Ángela M.; Simó, Rafael

2013-01-01

Retinal neurodegeneration is an early event in the pathogenesis of diabetic retinopathy (DR). Somatostatin (SST) is an endogenous neuroprotective peptide that is downregulated in the diabetic eye. The aim of the study was to test the usefulness of topical administration of SST in preventing retinal neurodegeneration. For this purpose, rats with streptozotocin-induced diabetes mellitus (STZ-DM) were treated with either SST eye drops or vehicle for 15 days. Nondiabetic rats treated with vehicle served as a control group. Functional abnormalities were assessed by electroretinography (ERG), and neurodegeneration was assessed by measuring glial activation and the apoptotic rate. In addition, proapoptotic (FasL, Bid, and activation of caspase-8 and caspase-3) and survival signaling pathways (BclxL) were examined. Intraretinal concentrations of glutamate and its main transporter glutamate/aspartate transporter (GLAST) were also determined. Treatment with SST eye drops prevented ERG abnormalities, glial activation, apoptosis, and the misbalance between proapoptotic and survival signaling detected in STZ-DM rats. In addition, SST eye drops inhibited glutamate accumulation in the retina and GLAST downregulation induced by diabetes mellitus. We conclude that topical administration of SST has a potent effect in preventing retinal neurodegeneration induced by diabetes mellitus. In addition, our findings open up a new preventive pharmacological strategy targeted to early stages of DR. PMID:23474487

Topical administration of somatostatin prevents retinal neurodegeneration in experimental diabetes.

PubMed

Hernández, Cristina; García-Ramírez, Marta; Corraliza, Lidia; Fernández-Carneado, Jimena; Farrera-Sinfreu, Josep; Ponsati, Berta; González-Rodríguez, Agueda; Valverde, Angela M; Simó, Rafael

2013-07-01

Retinal neurodegeneration is an early event in the pathogenesis of diabetic retinopathy (DR). Somatostatin (SST) is an endogenous neuroprotective peptide that is downregulated in the diabetic eye. The aim of the study was to test the usefulness of topical administration of SST in preventing retinal neurodegeneration. For this purpose, rats with streptozotocin-induced diabetes mellitus (STZ-DM) were treated with either SST eye drops or vehicle for 15 days. Nondiabetic rats treated with vehicle served as a control group. Functional abnormalities were assessed by electroretinography (ERG), and neurodegeneration was assessed by measuring glial activation and the apoptotic rate. In addition, proapoptotic (FasL, Bid, and activation of caspase-8 and caspase-3) and survival signaling pathways (BclxL) were examined. Intraretinal concentrations of glutamate and its main transporter glutamate/aspartate transporter (GLAST) were also determined. Treatment with SST eye drops prevented ERG abnormalities, glial activation, apoptosis, and the misbalance between proapoptotic and survival signaling detected in STZ-DM rats. In addition, SST eye drops inhibited glutamate accumulation in the retina and GLAST downregulation induced by diabetes mellitus. We conclude that topical administration of SST has a potent effect in preventing retinal neurodegeneration induced by diabetes mellitus. In addition, our findings open up a new preventive pharmacological strategy targeted to early stages of DR.

Pulsars and Acceleration Sites

NASA Technical Reports Server (NTRS)

Harding, Alice

2008-01-01

Rotation-powered pulsars are excellent laboratories for the studying particle acceleration as well as fundamental physics of strong gravity, strong magnetic fields and relativity. But even forty years after their discovery, we still do not understand their pulsed emission at any wavelength. I will review both the basic physics of pulsars as well as the latest developments in understanding their high-energy emission. Special and general relativistic effects play important roles in pulsar emission, from inertial frame-dragging near the stellar surface to aberration, time-of-flight and retardation of the magnetic field near the light cylinder. Understanding how these effects determine what we observe at different wavelengths is critical to unraveling the emission physics. Fortunately the Gamma-Ray Large Area Space Telescope (GLAST), with launch in May 2008 will detect many new gamma-ray pulsars and test the predictions of these models with unprecedented sensitivity and energy resolution for gamma-rays in the range of 30 MeV to 300 GeV.

High-Energy Emission from Rotation-Powered Pulsars

NASA Technical Reports Server (NTRS)

Harding, Alice K.

2007-01-01

Thirty-five years after the discovery of rotation-powered pulsars, we still do not understand their pulsed emission at any wavelength. In the last few years there have been some fundamental developments in acceleration and emission models. I will review both the basic physics of the models as well as the latest developments in understanding the high-energy emission of rotation-powered pulsars. Special and general relativistic effects play important roles in pulsar emission, from inertial frame-dragging near the stellar surface to aberration, time-of-flight and retardation of the magnetic field near the light cylinder. Understanding how these effects determine what we observe at different wavelengths is critical to unraveling the emission physics. Fortunately two new gamma-ray telescopes, AGILE and GLAST, with launches expected this year will detect many new gamma-ray pulsars and test the predictions of these models with unprecedented sensitivity and energy resolution for gamma-rays in the range of 30 MeV to 300 GeV.

GAP-43 is essential for the neurotrophic effects of BDNF and positive AMPA receptor modulator S18986.

PubMed

Gupta, S K; Mishra, R; Kusum, S; Spedding, M; Meiri, K F; Gressens, P; Mani, S

2009-04-01

Positive alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptor modulators include benzamide compounds that allosterically modulate AMPA glutamate receptors. These small molecules that cross the blood-brain barrier have been shown to act as a neuroprotectant by increasing the levels of endogenous brain-derived neurotrophic factor (BDNF). Positive AMPA receptor modulators have also been shown to increase the levels of growth-associated protein-43 (GAP-43). GAP-43 plays a major role in many aspects of neuronal function in vertebrates. The goal of this study was to determine whether GAP-43 was important in mediating the actions of positive AMPA receptor modulator (S18986) and BDNF. Using cortical cultures from GAP-43 knockout and control mice, we show that (1) GAP-43 is upregulated in response to S18986 and BDNF in control cultures; (2) this upregulation of GAP-43 is essential for mediating the neuroprotective effects of S18986 and BDNF; (3) administration of S18986 and BDNF leads to an increase in the expression of the glutamate transporters GLT-1 and GLAST that are key to limiting excitotoxic cell death and this increase in GLT-1 and GLAST expression is completely blocked in the absence of GAP-43. Taken together this study concludes that GAP-43 is an important mediator of the neurotrophic effects of S18986 and BDNF on neuronal survival and plasticity, and is essential for the success of positive AMPA receptor modulator-BDNF-based neurotrophin therapy.

Analysis of RXTE data on Clusters of Galaxies

NASA Technical Reports Server (NTRS)

Petrosian, Vahe

2004-01-01

This grant provided support for the reduction, analysis and interpretation of of hard X-ray (HXR, for short) observations of the cluster of galaxies RXJO658--5557 scheduled for the week of August 23, 2002 under the RXTE Cycle 7 program (PI Vahe Petrosian, Obs. ID 70165). The goal of the observation was to search for and characterize the shape of the HXR component beyond the well established thermal soft X-ray (SXR) component. Such hard components have been detected in several nearby clusters. distant cluster would provide information on the characteristics of this radiation at a different epoch in the evolution of the imiverse and shed light on its origin. We (Petrosian, 2001) have argued that thermal bremsstrahlung, as proposed earlier, cannot be the mechanism for the production of the HXRs and that the most likely mechanism is Compton upscattering of the cosmic microwave radiation by relativistic electrons which are known to be present in the clusters and be responsible for the observed radio emission. Based on this picture we estimated that this cluster, in spite of its relatively large distance, will have HXR signal comparable to the other nearby ones. The planned observation of a relatively The proposed RXTE observations were carried out and the data have been analyzed. We detect a hard X-ray tail in the spectrum of this cluster with a flux very nearly equal to our predicted value. This has strengthen the case for the Compton scattering model. We intend the data obtained via this observation to be a part of a larger data set. We have identified other clusters of galaxies (in archival RXTE and other instrument data sets) with sufficiently high quality data where we can search for and measure (or at least put meaningful limits) on the strength of the hard component. With these studies we expect to clarify the mechanism for acceleration of particles in the intercluster medium and provide guidance for future observations of this intriguing phenomenon by instrument on GLAST. The details of the nonthermal particle population has important implications for the theories of cluster formation, mergers and evolution. The results of this work were first presented at the High Energy Division meeting of the American astronomical Society at Mt. Tremblene, Canada (Petrosian et al. 2003). and in an invited review talk at the General Assembly of the International Astronomical Union at Sydney, Australia (Petrosian, 2003). A paper describe the observations, the data analysis and its implication is being prepared for publication in the Astrophysical Journal.

Cen A Optical Capella

NASA Image and Video Library

2017-12-08

NASA release April 1, 2010 The giant elliptical galaxy NGC 5128, show here in visible light, hosts the radio source known as Centaurus A. Located 12 million light-years away, it is one of the closest active galaxies. Credit: Capella Observatory To learn more about these images go to: www.nasa.gov/mission_pages/GLAST/news/smokestack-plumes.html NASA Goddard Space Flight Center is home to the nation's largest organization of combined scientists, engineers and technologists that build spacecraft, instruments and new technology to study the Earth, the sun, our solar system, and the universe.

Cen A Optical Capella

NASA Image and Video Library

2010-04-01

NASA release April 1, 2010 The giant elliptical galaxy NGC 5128, show here in visible light, hosts the radio source known as Centaurus A. Located 12 million light-years away, it is one of the closest active galaxies. Credit: Capella Observatory To learn more about these images go to: www.nasa.gov/mission_pages/GLAST/news/smokestack-plumes.html NASA Goddard Space Flight Center is home to the nation's largest organization of combined scientists, engineers and technologists that build spacecraft, instruments and new technology to study the Earth, the sun, our solar system, and the universe.

Chronic postnatal stress induces voluntary alcohol intake and modifies glutamate transporters in adolescent rats.

PubMed

Odeon, María Mercedes; Andreu, Marcela; Yamauchi, Laura; Grosman, Mauricio; Acosta, Gabriela Beatriz

2015-01-01

Postnatal stress alters stress responses for life, with serious consequences on the central nervous system (CNS), involving glutamatergic neurotransmission and development of voluntary alcohol intake. Several drugs of abuse, including alcohol and cocaine, alter glutamate transport (GluT). Here, we evaluated effects of chronic postnatal stress (CPS) on alcohol intake and brain glutamate uptake and transporters in male adolescent Wistar rats. For CPS from postnatal day (PD) 7, pups were separated from their mothers and exposed to cold stress (4 °C) for 1 h daily for 20 days; controls remained with their mothers. Then they were exposed to either voluntary ethanol (6%) or dextrose (1%) intake for 7 days (5-7 rats per group), then killed. CPS: (1) increased voluntary ethanol intake, (2) did not affect body weight gain or produce signs of toxicity with alcohol exposure, (3) increased glutamate uptake by hippocampal synaptosomes in vitro and (4) reduced protein levels (Western measurements) in hippocampus and frontal cortex of glial glutamate transporter-1 (GLT-1) and excitatory amino-acid transporter-3 (EAAT-3) but increased glutamate aspartate transporter (GLAST) levels. We propose that CPS-induced decrements in GLT-1 and EAAT-3 expression levels are opposed by activation of a compensatory mechanism to prevent excitotoxicity. A greater role for GLAST in total glutamate uptake to prevent enlarged extracellular glutamate levels is inferred. Although CPS strongly increased intake of ethanol, this had little impact on effects of CPS on brain glutamate uptake or transporters. However, the impact of early life adverse events on glutamatergic neurotransmission may underlie increased alcohol consumption in adulthood.

Prenatal exposure to PCP produces behavioral deficits accompanied by the overexpression of GLAST in the prefrontal cortex of postpubertal mice.

PubMed

Lu, Lingling; Mamiya, Takayoshi; Lu, Ping; Toriumi, Kazuya; Mouri, Akihiro; Hiramatsu, Masayuki; Zou, Li-Bo; Nabeshima, Toshitaka

2011-06-20

Altered glutamatergic neurotransmission in the prefrontal cortex (PFC) has been implicated in a myriad of neuropsychiatric disorders. We previously reported that prenatal exposure to PCP produced long-lasting behavioral deficits, accompanied by the abnormal expression and dysfunction of NMDA receptors. In addition, these behavioral changes were attenuated by clozapine treatment. However, whether the prenatal exposure adversely affects pre-synaptic glutamatergic neurotransmission in postpubertal mice remains unknown. In the present study, we investigated the involvement of prefrontal glutamatergic neurotransmission in the impairment of cognitive and emotional behavior after prenatal PCP treatment (5mg/kg/day) from E6 to E18 in mice. The PCP-treated mice showed an impairment of recognition memory in a novel object recognition test and enhancement of immobility in a forced swimming test at 8 weeks of age. Moreover, the prenatal treatment reduced the extracellular glutamate level, but increased the expression of a glial glutamate transporter (GLAST) in the PFC. The microinjection of DL-threo-β-benzyloxyaspartate (DL-TBOA, 10 nmol/site/bilaterally), a potent blocker of glutamate transporters, reversed these behavioral deficits by enhancing the prefrontal glutamatergic neurotransmission. Taken together, prenatal exposure to PCP produced impairments of long-term memory and emotional function which are associated with abnormalities of pre-synaptic glutamate transmission in the PFC of postpubertal mice. These findings suggest the prenatal inhibition of NMDA receptor function to contribute partly to the pathophysiology of neurodevelopment-related disorders, such as schizophrenia. Copyright © 2011 Elsevier B.V. All rights reserved.

Modeling the emission processes in blazars

NASA Astrophysics Data System (ADS)

Böttcher, Markus

2007-06-01

Blazars are the most violent steady/recurrent sources of high-energy gamma-ray emission in the known Universe. They are prominent emitters of electromagnetic radiation throughout the entire electromagnetic spectrum. The observable radiation most likely originates in a relativistic jet oriented at a small angle with respect to the line of sight. This review starts out with a general overview of the phenomenology of blazars, including results from a recent multiwavelength observing campaign on 3C279. Subsequently, issues of modeling broadband spectra will be discussed. Spectral information alone is not sufficient to distinguish between competing models and to constrain essential parameters, in particular related to the primary particle acceleration and radiation mechanisms in the jet. Short-term spectral variability information may help to break such model degeneracies, which will require snap-shot spectral information on intraday time scales, which may soon be achievable for many blazars even in the gamma-ray regime with the upcoming GLAST mission and current advances in Atmospheric Cherenkov Telescope technology. In addition to pure leptonic and hadronic models of gamma-ray emission from blazars, leptonic/hadronic hybrid models are reviewed, and the recently developed hadronic synchrotron mirror model for TeV γ-ray flares which are not accompanied by simultaneous X-ray flares (“orphan TeV flares”) is revisited.

Simulation of Cosmic Ray Acceleration, Propagation and Interaction in SNR Environment

NASA Astrophysics Data System (ADS)

Lee, S. H.; Kamae, T.; Ellison, D. C.

2007-07-01

Recent studies of young supernova remnants (SNRs) with Chandra, XMM, Suzaku and HESS have revealed complex morphologies and spectral features of the emission sites. The critical question of the relative importance of the two competing gamma-ray emission mechanisms in SNRs; inverse-Compton scattering by high-energy electrons and pion production by energetic protons, may be resolved by GLAST-LAT. To keep pace with the improved observations, we are developing a 3D model of particle acceleration, diffusion, and interaction in a SNR where broad-band emission from radio to multi-TeV energies, produced by shock accelerated electrons and ions, can be simulated for a given topology of shock fronts, magnetic field, and ISM densities. The 3D model takes as input, the particle spectra predicted by a hydrodynamic simulation of SNR evolution where nonlinear diffusive shock acceleration is coupled to the remnant dynamics (e.g., Ellison, Decourchelle & Ballet; Ellison & Cassam-Chenai Ellison, Berezhko & Baring). We will present preliminary models of the Galactic Ridge SNR RX J1713-3946 for selected choices of SNR parameters, magnetic field topology, and ISM density distributions. When constrained by broad-band observations, our models should predict the extent of coupling between spectral shape and morphology and provide direct information on the acceleration efficiency of cosmic-ray electrons and ions in SNRs.

Methylphenidate administration determines enduring changes in neuroglial network in rats.

PubMed

Cavaliere, Carlo; Cirillo, Giovanni; Bianco, Maria Rosaria; Adriani, Walter; De Simone, Antonietta; Leo, Damiana; Perrone-Capano, Carla; Papa, Michele

2012-01-01

Repeated exposure to psychostimulant drugs induces complex molecular and structural modifications in discrete brain regions of the meso-cortico-limbic system. This structural remodeling is thought to underlie neurobehavioral adaptive responses. Administration to adolescent rats of methylphenidate (MPH), commonly used in attention deficit and hyperactivity disorder (ADHD), triggers alterations of reward-based behavior paralleled by persistent and plastic synaptic changes of neuronal and glial markers within key areas of the reward circuits. By immunohistochemistry, we observe a marked increase of glial fibrillary acidic protein (GFAP) and neuronal nitric oxide synthase (nNOS) expression and a down-regulation of glial glutamate transporter GLAST in dorso-lateral and ventro-medial striatum. Using electron microscopy, we find in the prefrontal cortex a significant reduction of the synaptic active zone length, paralleled by an increase of dendritic spines. We demonstrate that in limbic areas the MPH-induced reactive astrocytosis affects the glial glutamatergic uptake system that in turn could determine glutamate receptor sensitization. These processes could be sustained by NO production and synaptic rearrangement and contribute to MPH neuroglial induced rewiring. Copyright © 2011. Published by Elsevier B.V.

Cosmic Infrared Background From Population III Stars and Its Effect on Spectra of High-z Gamma-Ray Bursts

NASA Technical Reports Server (NTRS)

Kashlinsky, A.

2005-01-01

We discuss the contribution of Population III stars to the near-IR (NIR) cosmic infrared background (CIB) and its effect on spectra of high-z, high-energy gamma-ray bursts (GRBs) and other sources. It is shown that if Population III is composed of massive stars, the claimed NIR CIB excess will be reproduced if only approx. 4% plus or minus 2% of all baryons went through these stars. Regardless of the precise amount of the NIR CIB due to them, they likely left enough photons to provide a large optical depth for high-energy photons from distant GRBs. Observations of such GRBs are expected following the planned launch of NASA's GLAST mission. Detecting such damping in the spectra of high-z GRBs will then provide important information on the emissions from the Population III epoch, and the location of this cutoff may serve as an indicator of the GRBs' redshifts. We also point out the difficulty of unambiguously detecting the CIB part originating from Population III in spectra of low-z blazars.

Alteration in 5-HT₂C, NMDA receptor and IP3 in cerebral cortex of epileptic rats: restorative role of Bacopa monnieri.

PubMed

Krishnakumar, Amee; Anju, T R; Abraham, Pretty Mary; Paulose, C S

2015-01-01

Bacopa monnieri is effective in stress management, brain function and a balanced mood. 5-HT2C receptors have been implicated in stress whereas NMDA receptors and mGlu5 play crucial role in memory and cognition. In the present study, we investigated the role of B. monnieri extract in ameliorating pilocarpine induced temporal lobe epilepsy through regulation of 5-HT2C and NMDA receptors in cerebral cortex. Our studies confirmed an increased 5-HT2C receptor function during epilepsy thereby facilitating IP3 release. We also observed an decreased NMDA receptor function with an elevated mGlu5 and GLAST gene expression in epileptic condition indicating the possibility for glutamate mediated excitotoxicity. These alterations lead to impaired behavioural functions as indicated by the Elevated Plus maze test. Carbamazepine and B. monnieri treatments to epileptic rats reversed the alterations in 5-HT2C, NMDA receptor functions and IP3 content thereby effectively managing the neurotransmitter balance in the cerebral cortex.

Detecting Axionlike Particles with Gamma Ray Telescopes

NASA Astrophysics Data System (ADS)

Hooper, Dan; Serpico, Pasquale D.

2007-12-01

We propose that axionlike particles (ALPs) with a two-photon vertex, consistent with all astrophysical and laboratory bounds, may lead to a detectable signature in the spectra of high-energy gamma-ray sources. This occurs as a result of gamma rays being converted into ALPs in the magnetic fields of efficient astrophysical accelerators according to the “Hillas criterion”, such as jets of active galactic nuclei or hot spots of radio galaxies. The discovery of such an effect is possible by GLAST in the 1 100 GeV range and by ground-based gamma-ray telescopes in the TeV range.

An Analysis Methodology for the Gamma-ray Large Area Space Telescope

NASA Technical Reports Server (NTRS)

Morris, Robin D.; Cohen-Tanugi, Johann

2004-01-01

The Large Area Telescope (LAT) instrument on the Gamma Ray Large Area Space Telescope (GLAST) has been designed to detect high-energy gamma rays and determine their direction of incidence and energy. We propose a reconstruction algorithm based on recent advances in statistical methodology. This method, alternative to the standard event analysis inherited from high energy collider physics experiments, incorporates more accurately the physical processes occurring in the detector, and makes full use of the statistical information available. It could thus provide a better estimate of the direction and energy of the primary photon.

Abnormal neural precursor cell regulation in the early postnatal Fragile X mouse hippocampus.

PubMed

Sourial, Mary; Doering, Laurie C

2017-07-01

The regulation of neural precursor cells (NPCs) is indispensable for a properly functioning brain. Abnormalities in NPC proliferation, differentiation, survival, or integration have been linked to various neurological diseases including Fragile X syndrome. Yet, no studies have examined NPCs from the early postnatal Fragile X mouse hippocampus despite the importance of this developmental time point, which marks the highest expression level of FMRP, the protein missing in Fragile X, in the rodent hippocampus and is when hippocampal NPCs have migrated to the dentate gyrus (DG) to give rise to lifelong neurogenesis. In this study, we examined NPCs from the early postnatal hippocampus and DG of Fragile X mice (Fmr1-KO). Immunocytochemistry on neurospheres showed increased Nestin expression and decreased Ki67 expression, which collectively indicated aberrant NPC biology. Intriguingly, flow cytometric analysis of the expression of the antigens CD15, CD24, CD133, GLAST, and PSA-NCAM showed a decreased proportion of neural stem cells (GLAST + CD15 + CD133 + ) and an increased proportion of neuroblasts (PSA-NCAM + CD15 + ) in the DG of P7 Fmr1-KO mice. This was mirrored by lower expression levels of Nestin and the mitotic marker phospho-histone H3 in vivo in the P9 hippocampus, as well as a decreased proportion of cells in the G 2 /M phases of the P7 DG. Thus, the absence of FMRP leads to fewer actively cycling NPCs, coinciding with a decrease in neural stem cells and an increase in neuroblasts. Together, these results show the importance of FMRP in the developing hippocampal formation and suggest abnormalities in cell cycle regulation in Fragile X. Crown Copyright © 2017. Published by Elsevier B.V. All rights reserved.

Beyond the Event Horizon: Education with Black Holes

NASA Astrophysics Data System (ADS)

Silva, Sarah; Cominsky, L.; Plait, P.; SSU E/PO Group

2006-09-01

The Sonoma State University NASA Education and Public Outreach Program (SSU E/PO), in collaboration with the Denver Museum of Nature & Science (DMNS), NOVA, Thomas Lucas Productions (TLP), the National Science Foundation and E/PO groups across NASA's Astrophysics Division, is creating a series of educational and outreach products for both formal and informal educational settings. The formal (in-class) products are closely tied with the informal (museum and television) products. An NSF-funded digital planetarium show titled "Black Holes: The Other Side of Infinity" was created by DMNS and TLP and is currently showing at several venues, with more planned. Through funding from the Swift and GLAST missions, SSU has developed an accompanying educator workshop and guide to train museum personnel in the use of black hole educational materials so that they can give professional development workshops to local teachers. In addition, SSU E/PO has worked with TLP and NOVA to create a television program ("Monster of the Milky Way") will premiere in the fall of 2006 with accompanying online educational materials. The educator guide materials include activities from NASA Astrophysics missions such as GLAST, Swift, XMM-Newton, and Gravity Probe-B, as well as from the Center for Science Education at Space Sciences Laboratory and the HEASARC education programs. We are also creating an online educational resource for use by anyone who wants to find information about black holes. It will have interactive features, including a possible museum kiosk where visitors can explore black holes. All products that are developed as a part of this program include integrated evaluation and assessment. The planetarium show has already had formative evaluation and is in the process of summative evaluation. The workshops include evaluation and follow-up work with the participating educators.

17β-estradiol and tamoxifen protect mice from manganese-induced dopaminergic neurotoxicity.

PubMed

Pajarillo, Edward; Johnson, James; Kim, Judong; Karki, Pratap; Son, Deok-Soo; Aschner, Michael; Lee, Eunsook

2018-03-01

Chronic exposure to manganese (Mn) causes neurotoxicity, referred to as manganism, with common clinical features of parkinsonism. 17β-estradiol (E2) and tamoxifen (TX), a selective estrogen receptor modulator (SERM), afford neuroprotection in several neurological disorders, including Parkinson's disease (PD). In the present study, we tested if E2 and TX attenuate Mn-induced neurotoxicity in mice, assessing motor deficit and dopaminergic neurodegeneration. We implanted E2 and TX pellets in the back of the neck of ovariectomized C57BL/6 mice two weeks prior to a single injection of Mn into the striatum. One week later, we assessed locomotor activity and molecular mechanisms by immunohistochemistry, real-time quantitative PCR, western blot and enzymatic biochemical analyses. The results showed that both E2 and TX attenuated Mn-induced motor deficits and reversed the Mn-induced loss of dopaminergic neurons in the substantia nigra. At the molecular level, E2 and TX reversed the Mn-induced decrease of (1) glutamate aspartate transporter (GLAST) and glutamate transporter 1 (GLT-1) mRNA and protein levels; (2) transforming growth factor-α (TGF-α) and estrogen receptor-α (ER-α) protein levels; and (3) catalase (CAT) activity and glutathione (GSH) levels, and Mn-increased (1) malondialdehyde (MDA) levels and (2) the Bax/Bcl-2 ratio. These results indicate that E2 and TX afford protection against Mn-induced neurotoxicity by reversing Mn-reduced GLT1/GLAST as well as Mn-induced oxidative stress. Our findings may offer estrogenic agents as potential candidates for the development of therapeutics to treat Mn-induced neurotoxicity. Copyright © 2017 Elsevier B.V. All rights reserved.

FERMI/GLAST Integrated Trending and Plotting System Release 5.0

NASA Technical Reports Server (NTRS)

Ritter, Sheila; Brumer, Haim; Reitan, Denise

2012-01-01

An Integrated Trending and Plotting System (ITPS) is a trending, analysis, and plotting system used by space missions to determine performance and status of spacecraft and its instruments. ITPS supports several NASA mission operational control centers providing engineers, ground controllers, and scientists with access to the entire spacecraft telemetry data archive for the life of the mission, and includes a secure Web component for remote access. FERMI/GLAST ITPS Release 5.0 features include the option to display dates (yyyy/ddd) instead of orbit numbers along orbital Long-Term Trend (LTT) plot axis, the ability to save statistics from daily production plots as image files, and removal of redundant edit/create Input Definition File (IDF) screens. Other features are a fix to address invalid packet lengths, a change in naming convention of image files in order to use in script, the ability to save all ITPS plot images (from Windows or the Web) as GIF or PNG format, the ability to specify ymin and ymax on plots where previously only the desired range could be specified, Web interface capability to plot IDFs that contain out-oforder page and plot numbers, and a fix to change all default file names to show yyyydddhhmmss time stamps instead of hhmmssdddyyyy. A Web interface capability sorts files based on modification date (with newest one at top), and the statistics block can be displayed via a Web interface. Via the Web, users can graphically view the volume of telemetry data from each day contained in the ITPS archive in the Web digest. The ITPS could be also used in nonspace fields that need to plot data or trend data, including financial and banking systems, aviation and transportation systems, healthcare and educational systems, sales and marketing, and housing and construction.

Cen A Optical Gamma Composite

NASA Image and Video Library

2017-12-08

NASA release April 1, 2010 The gamma-ray output from Cen A's lobes exceeds their radio output by more than ten times. High-energy gamma rays detected by Fermi's Large Area Telescope are depicted as purple in this gamma ray/optical composite of the galaxy. Credit: NASA/DOE/Fermi LAT Collaboration, Capella Observatory To learn more about these images go to: www.nasa.gov/mission_pages/GLAST/news/smokestack-plumes.html NASA Goddard Space Flight Center is home to the nation's largest organization of combined scientists, engineers and technologists that build spacecraft, instruments and new technology to study the Earth, the sun, our solar system, and the universe.

Monitoring Accreting X-ray Pulsars with the GLAST Burst Monitor

NASA Technical Reports Server (NTRS)

Wilson, Colleen A.; Finger, Mark H.; Patel, Sandeep K.; Bhat, P. Narayana; Preece, Robert D.; Meegan, Charles A.

2007-01-01

Accreting pulsars are exceptionally good laboratories for probing the detailed physics of accretion onto magnetic stars. While similar accretion flows also occur in other types of astrophysical systems, e.g. magnetic CVs, only neutron stars have a small enough moment of inertia for the accretion of angular momentum to result in measurable changes in spin-frequency in a timescale of days. Long-term monitoring of accreting pulsar spin-frequencies and fluxes was demonstrated with the Burst and Transient Source Experiment (BATSE) on the Compton Gamma Ray Observatory. Here we present sample results from BATSE, discuss measurement techniques appropriate for GBM, and estimate the expected GBM sensitivity.

GRBs: The Most Distant Signposts in our Universe

NASA Technical Reports Server (NTRS)

Kouveliotou, Chryssa

2007-01-01

Gamma-Ray Bursts (GRBs) are the most powerful photon sources in the Universe, rivaled only by supernovae in the magnitude of their energy release. In 1997 GRB were found to originate in host galaxies at cosmological distances, revealing the total energy of their explosions to be an astounding approx.10(exp 52) - 10(exp 53)ergs. GRB durations span over five orders of magnitude, ranging from milliseconds to thousands of seconds. The underlying sources of the energy release remain, however, unknown. Leading candidates are mergers, either of two neutron stars or of a black hole and a neutron star, and core collapses of very massive stars, called "collapsars". To date the furthest GRB galaxy has been found at a cosmological redshift of 6.29, very close to the most distant quasar (at z=6.4). Since the Swift satellite continues to observe these phenomena at a rate of approx.120 per year, and with the upcoming launch of GLAST with two burst instruments on board, we will be able to use GRBs as beacons to probe very high redshifts. Thus bursts found at 6

An Effective Theory of Dirac Dark Matter

DOE Office of Scientific and Technical Information (OSTI.GOV)

Harnik, Roni; /Stanford U., Phys. Dept. /SLAC; Kribs, Graham D.

2010-06-11

A stable Dirac fermion with four-fermion interactions to leptons suppressed by a scale {Lambda} {approx} 1 TeV is shown to provide a viable candidate for dark matter. The thermal relic abundance matches cosmology, while nuclear recoil direct detection bounds are automatically avoided in the absence of (large) couplings to quarks. The annihilation cross section in the early Universe is the same as the annihilation in our galactic neighborhood. This allows Dirac fermion dark matter to naturally explain the positron ratio excess observed by PAMELA with a minimal boost factor, given present astrophysical uncertainties. We use the Galprop program for propagationmore » of signal and background; we discuss in detail the uncertainties resulting from the propagation parameters and, more importantly, the injected spectra. Fermi/GLAST has an opportunity to see a feature in the gamma-ray spectrum at the mass of the Dirac fermion. The excess observed by ATIC/PPB-BETS may also be explained with Dirac dark matter that is heavy. A supersymmetric model with a Dirac bino provides a viable UV model of the effective theory. The dominance of the leptonic operators, and thus the observation of an excess in positrons and not in anti-protons, is naturally explained by the large hypercharge and low mass of sleptons as compared with squarks. Minimizing the boost factor implies the right-handed selectron is the lightest slepton, which is characteristic of our model. Selectrons (or sleptons) with mass less than a few hundred GeV are an inescapable consequence awaiting discovery at the LHC.« less

Flavonoid constituents of Dobera glabra leaves: amelioration impact against CCl4-induced changes in the genetic materials in male rats.

PubMed

Elkhateeb, Ahmed; Abdel Latif, Rasha R; Marzouk, Mona M; Hussein, Sameh R; Kassem, Mona E S; Khalil, Wagdy K B; El-Ansari, Mohamed A

2017-12-01

Dobera glabra (Forssk.) Poir (Salvadoraceae) is a highly valued tree with diverse importance as special mineral sourced feed and a folkloric tool for forecasting droughts. However, there are no reports on its phytochemical and biological investigations. Phytochemical investigation of D. glabra leaves and its protective potential against CCl 4 inducing changes in the genetic materials. D. glabra extract, DGE (70% MeOH/H 2 O), was applied to polyamide column chromatography, eluting with MeOH/H 2 O of decreasing polarities, followed by preparative chromatographic tools, yielded seven compounds. Three DGE doses (50, 100 and 200 mg/kg bw/d) were administrated for 8 weeks intragastrically to male albino rats prior treated with CCl 4 (0.5 mL/kg/bw). The reactive oxygen species (ROS) levels, expression changes of glutamate transporters (GLAST, GLT-1 and SNAT3) mRNA, DNA fragmentation and glutathione peroxidase (GPx) activity were investigated in the liver tissues of these rats. Isorhamnetin-3-O-β-glucopyranoside-7-O-α-rhamnopyranoside, isorhamnetin-3-O-α-rhamnopyranoside-7-O-β-glucopyranoside, kaempferol-3,7-di-O-α-rhamnopyranoside, isorhamnetin-3-O-β-glucopyranoside, kaempferol-3-O-β-glucopyranoside, isorhamnetin and kaempferol were identified. DGE (200 mg/kg bw) + CCl 4 exhibited the most significant reduction in ROS levels and DNA fragmentation with 251.3% and141% compared to 523.1% and 273.2% for CCl 4 , respectively. Additionally, it increased significantly the mRNA expression of GLAST, GLT-1 and SNAT3 to 2.16-, 1.72- and 2.09-fold, respectively. Also, GPx activity was increased to 4.8 U/mg protein/min compared to CCl 4 (1.8 U/mg protein/min). Flavonoid constituents, antioxidant effect and genotoxic protection activity of D. glabra were first reported. DGE may be valuable in the treatment and hindrance of hepatic oxidative stress and genotoxicity.

The Role of Beam Geometry in Population Statistics and Pulse Profiles of Radio and Gamma-ray Pulsars

NASA Technical Reports Server (NTRS)

Gonthier, Peter L.; VanGuilder, Robert; Harding, Alice K.

2004-01-01

We present results of a pulsar population synthesis study that incorporates a number of recent developments and some significant improvements over our previous study. We have included the results of the Parkes multi-beam pulsar survey in our select group of nine radio surveys, doubling our sample of radio pulsars. More realistic geometries for the radio and gamma-ray beams are included in our Monte Carlo computer code that simulates the characteristics of the Galactic population of radio and gamma-ray pulsars. We adopted with some modifications the radio beam geometry of Arzoumanian, Chernoff & Cordes (2002). For the gamma-ray beam, we have assumed the slot gap geometry described in the work of Muslimov & Harding (2003). To account for the shape of the distribution of radio pulsars in the P(dot) - P diagram, we continue to find that decay of the magnetic field on a timescale of 2.8 Myr is needed. With all nine surveys, our model predicts that EGRET should have seen 7 radio-quiet (below the sensitivity of these radio surveys) and 19 radio-loud gamma-ray pulsars. AGILE (nominal sensitivity map) is expected to detect 13 radio-quiet and 37 radio-loud gamma-ray pulsars, while GLAST, with greater sensitivity is expected to detect 276 radio-quiet and 344 radio-loud gamma-ray pulsars. When the Parkes multi-beam pulsar survey is excluded, the ratio of radio-loud to radio-quiet gamma-ray pulsars decreases, especially for GLAST. The decrease for EGRET is 45%, implying that some fraction of EGRET unidentified sources are radio-loud gamma-ray pulsars. In the radio geometry adopted, short period pulsars are core dominated. Unlike the EGRET gamma-ray pulsars, our model predicts that when two gamma-ray peaks appear in the pulse profile, a dominant radio core peak appears in between the gamma-ray peaks. Our findings suggest that further improvements are required in describing both the radio and gamma-ray geometries.

From MAGIC to CTA: the INAF participation to Cherenkov Telescopes experiments for very high energy astrophysics .

NASA Astrophysics Data System (ADS)

Antonelli, L. A.; INAF MAGIC Collaboration

The next decade can be considered the "golden age" of the Gamma Ray Astronomy with the two satellites for Gamma Ray Astronomy (AGILE and GLAST) in orbit. Therefore, thanks to many other X-ray experiments already in orbit (e.g. Swift, Chandra, NewtonXMM, etc.) it will be possible to image the Universe for the first time all over the electromagnetic spectrum almost contemporarily. The new generations of ground-based very high gamma-ray instruments are ready to extend the observed band also to the very high frequencies. Scientists from the Italian National Institute for Astrophysics (INAF) are involved in many, both space- and ground- based gamma ray experiments, and recently such an involvement has been largely improved in the field of the Imaging Atmospheric Cherenkov Telescopes (IACT). INAF is now member of the MAGIC collaboration and is participating to the realization of the second MAGIC telescope. MAGIC, as well other IACT experiments, is not operated as an observatory so a proper guest observer program does not exist. A consortium of European scientists (including INAF scientists) is thus now thinking to the design of a new research infrastructure: the Cherenkov Telescope Array (CTA). CTA is conceived to provide 10 times the sensitivity of current instruments, combined with increased flexibility and increased coverage from some 10 GeV to some 100 TeV. CTA will be operated as an observatory to serve a wider community of astronomer and astroparticle physicists.

Gamma-ray and radio properties of six pulsars detected by the Fermi Large Area Telescope

DOE PAGES

Weltevrede, P.

2009-12-22

Here, we report the detection of pulsed γ-rays for PSRs J0631+1036, J0659+1414, J0742-2822, J1420-6048, J1509-5850, and J1718-3825 using the Large Area Telescope on board the Fermi Gamma-ray Space Telescope (formerly known as GLAST). Although these six pulsars are diverse in terms of their spin parameters, they share an important feature: their γ-ray light curves are (at least given the current count statistics) single peaked. For two pulsars, there are hints for a double-peaked structure in the light curves. The shapes of the observed light curves of this group of pulsars are discussed in the light of models for which themore » emission originates from high up in the magnetosphere. We observed phases of the γ-ray light curves are and, in general, they are consistent with those predicted by high-altitude models, although we speculate that the γ-ray emission of PSR J0659+1414, possibly featuring the softest spectrum of all Fermi pulsars coupled with a very low efficiency, arises from relatively low down in the magnetosphere. High-quality radio polarization data are available showing that all but one have a high degree of linear polarization. Furthermore, this allows us to place some constraints on the viewing geometry and aids the comparison of the γ-ray light curves with high-energy beam models.« less

NASA's Fermi Telescope Resolves Radio Galaxy Centaurus A

NASA Image and Video Library

2017-12-08

NASA release April 1, 2010 Fermi's Large Area Telescope resolved high-energy gamma rays from an extended region around the active galaxy Centaurus A. The emission corresponds to million-light-year-wide radio-emitting gas thrown out by the galaxy's supersized black hole. This inset shows an optical/gamma-ray composite of the galaxy and its location on the Fermi one-year sky map. Credit: NASA/DOE/Fermi LAT Collaboration, Capella Observatory To learn more about these images go to: www.nasa.gov/mission_pages/GLAST/news/smokestack-plumes.html NASA Goddard Space Flight Center is home to the nation's largest organization of combined scientists, engineers and technologists that build spacecraft, instruments and new technology to study the Earth, the sun, our solar system, and the universe.

Fermi at Six Months

NASA Technical Reports Server (NTRS)

Hays, Elizabeth

2009-01-01

An overview of the Fermi Gamma-ray Space Telescope's first 6 months in operation is provided. The Fermi Gamma-ray Space Telescope, formerly called GLAST, is a mission to measure the cosmic gamma-ray flux in the energy rage 20 MeV to more than 300 GeV, with supporting measurements for gamma-ray bursts from 8 keV to 30 MeV. It contains a Large Area Telescope capable of viewing the entire sky every 3 hours and a Gamma-ray Burst Monitor for viewing the entire unocculted sky. Since its launch on June 11, 2008 Fermi has provided information on pulsars, gamma ray bursts, relativistic jets, the active galactic nucleus, and a globular star cluster. This presentation describes Fermi's development, mission, instruments and recent findings.

GeV-gamma-ray emission regions

NASA Image and Video Library

2017-12-08

NASA's Fermi Closes on Source of Cosmic Rays New images from NASA's Fermi Gamma-ray Space Telescope show where supernova remnants emit radiation a billion times more energetic than visible light. The images bring astronomers a step closer to understanding the source of some of the universe's most energetic particles -- cosmic rays. Fermi mapped GeV-gamma-ray emission regions (magenta) in the W44 supernova remnant. The features clearly align with filaments detectable in other wavelengths. This composite merges X-rays (blue) from the Germany-led ROSAT mission, infrared (red) from NASA's Spitzer Space Telescope, and radio (orange) from the Very Large Array near Socorro, N.M. Credit: NASA/DOE/Fermi LAT Collaboration, ROSAT, JPL-Caltech, and NRAO/AUI For more information: www.nasa.gov/mission_pages/GLAST/news/cosmic-rays-source....

Dark matter and the first stars

NASA Astrophysics Data System (ADS)

Spolyar, Douglas

The first stars in the universe (Pop. III stars) mark the birth of the visible and dynamical universe, which we are familiar with: stars galaxies, clusters, etc. They are also important for reionizing the universe, creating the metals needed for subsequent populations of stars and not to mention us. They are possible seeds for super massive black holes which power quasars and are found at the center of galaxies such as the Milky Way galaxy. In this thesis, we argue that if DM is a Weakly Interacting Massive Particle (WIMP), then DM can be an important heat source for the first stars. WIMPs are arguably from a particle physics perspective the most popular DM candidate and are being looked for in numerous experiments such as LHC, CDMS, and GLAST. DM heating would dramatically change the nature of the first stars. Stars powered by DM are larger and cooler than typical Pop. III stars. These differences would alter the metals and abundances produced by the first stars, the ionization history of the universe, and alter the formation of later stellar populations. Effects caused by stars powered by dark matter may also be tested with 21 cm line Tomography, JWST, 30 meter telescopes, Planck, and GLAST. This thesis has been written with an anthology in mind. Thus the thesis will be organized into an introduction followed by a series of papers which will illuminate the effects which DM can have on the first stars. The first paper will argue that DM can dramatically change the formation of the first stars. The second paper discusses DM capture as an important source of DM for the first stars. The third paper tests the effectiveness of the Blumenthal method. The fourth and fifth papers look at the effects of DM upon the evolution of Pop. III stars. As a note, primordial black holes are also a popular DM candidate. The final paper looks at primordial black hole's effect upon the first stars. Thus, we argue that DM in the guise of WIMPs and primordial black holes can dramatically alter the nature of the first stars.

Photoperiodic regulation of glycogen metabolism, glycolysis, and glutamine synthesis in tanycytes of the Siberian hamster suggests novel roles of tanycytes in hypothalamic function.

PubMed

Nilaweera, Kanishka; Herwig, Annika; Bolborea, Matei; Campbell, Gill; Mayer, Claus D; Morgan, Peter J; Ebling, Francis J P; Barrett, Perry

2011-11-01

The objective of this study is to investigate the impact of photoperiod on the temporal and spatial expression of genes involved in glucose metabolism in the brain of the seasonal mammal Phodopus sungorus (Siberian hamster). In situ hybridization was performed on brain sections obtained from male hamsters held in long photoperiod (high body weight and developed testes) or short photoperiod (reduced body weight with testicular regression). This analysis revealed upregulation in expression of genes involved in glycogen and glucose metabolism in short photoperiod and localized to the tanycyte layer of the third ventricle. On the basis of these data and a previously identified photoperiod-dependent increase in activity of neighboring hypothalamic neurons, we hypothesized that the observed expression changes may reflect alteration in either metabolic fuel or precursor neurotransmitter supply to surrounding neurons. Gene expression analysis was performed for genes involved in lactate and glutamate transport. This analysis showed that the gene for the lactate transporter MCT2 and glutamate transporter GLAST was decreased in the tanycyte layer in short photoperiod. Expression of mRNA for glutamine synthetase, the final enzyme in the synthesis of the neuronal neurotransmitter precursor, glutamine, was also decreased in short photoperiod. These data suggest a role for tanycytes in modulating glutamate concentrations and neurotransmitter supply in the hypothalamic environment. Copyright © 2011 Wiley-Liss, Inc.

Air shower detectors in gamma-ray astronomy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sinnis, Gus

2008-01-01

Extensive air shower (EAS) arrays directly detect the particles in an EAS that reach the observation altitude. This detection technique effectively makes air shower arrays synoptic telescopes -- they are capable of simultaneously and continuously viewing the entire overhead sky. Typical air shower detectors have an effective field-of-view of 2 sr and operate nearly 100% of the time. These two characteristics make them ideal instruments for studying the highest energy gamma rays, extended sources and transient phenomena. Until recently air shower arrays have had insufficient sensitivity to detect gamma-ray sources. Over the past decade, the situation has changed markedly. Milagro,more » in the US, and the Tibet AS{gamma} array in Tibet, have detected very-high-energy gamma-ray emission from the Crab Nebula and the active galaxy Markarian 421 (both previously known sources). Milagro has discovered TeV diffuse emission from the Milky Way, three unidentified sources of TeV gamma rays, and several candidate sources of TeV gamma rays. Given these successes and the suite of existing and planned instruments in the GeV and TeV regime (AGILE, GLAST, HESS, VERITAS, CTA, AGIS and IceCube) there are strong reasons for pursuing a next generation of EAS detectors. In conjunction with these other instruments the next generation of EAS instruments could answer long-standing problems in astrophysics.« less

Thyroid hormone is required for pruning, functioning and long-term maintenance of afferent inner hair cell synapses

PubMed Central

Sundaresan, Srividya; Kong, Jee-Hyun; Fang, Qing; Salles, Felipe T.; Wangsawihardja, Felix; Ricci, Anthony J.; Mustapha, Mirna

2016-01-01

Functional maturation of afferent synaptic connections to inner hair cells (IHCs) involves pruning of excess synapses formed during development, as well as the strengthening and survival of the retained synapses. These events take place during the thyroid hormone (TH)-critical period of cochlear development, which is in the perinatal period for mice and in the third trimester for humans. Here, we used the hypothyroid Snell dwarf mouse (Pit1dw) as a model to study the role of TH in afferent type I synaptic refinement and functional maturation. We observed defects in afferent synaptic pruning and delays in calcium channel clustering in the IHCs of Pit1dw mice. Nevertheless, calcium currents and capacitance reached near normal levels in Pit1dw IHCs by the age of onset of hearing, despite the excess number of retained synapses. We restored normal synaptic pruning in Pit1dw IHCs by supplementing with TH from postnatal day (P)3 to P8, establishing this window as being critical for TH action on this process. Afferent terminals of older Pit1dw IHCs showed evidence of excitotoxic damage accompanied by a concomitant reduction in the levels of the glial glutamate transporter, GLAST. Our results indicate that a lack of TH during a critical period of inner ear development causes defects in pruning and long-term homeostatic maintenance of afferent synapses. PMID:26386265

Young Stellar Grouping in Cygnus X

NASA Image and Video Library

2017-12-08

Cygnus X hosts many young stellar groupings. The combined outflows and ultraviolet radiation from the region's numerous massive stars have heated and pushed gas away from the clusters, producing cavities of hot, lower-density gas. In this 8-micron infrared image, ridges of denser gas mark the boundaries of the cavities. Bright spots within these ridges show where stars are forming today. Credit: NASA/IPAC/MSX To read more go to: www.nasa.gov/mission_pages/GLAST/news/cygnus-cocoon.html NASA image use policy. NASA Goddard Space Flight Center enables NASA’s mission through four scientific endeavors: Earth Science, Heliophysics, Solar System Exploration, and Astrophysics. Goddard plays a leading role in NASA’s accomplishments by contributing compelling scientific knowledge to advance the Agency’s mission. Follow us on Twitter Like us on Facebook Find us on Instagram

Cen A Radio Optical Gamma Composite

NASA Image and Video Library

2017-12-08

NASA release April 1, 2010 It takes the addition of radio data (orange) to fully appreciate the scale of Cen A's giant radio-emitting lobes, which stretch more than 1.4 million light-years. Gamma-rays from Fermi's Large Area Telescope (purple) and an image of the galaxy in visible light are also included in this composite. Credit: NASA/DOE/Fermi LAT Collaboration, Capella Observatory, and Ilana Feain, Tim Cornwell, and Ron Ekers (CSIRO/ATNF), R. Morganti (ASTRON), and N. Junkes (MPIfR) To learn more about these images go to: www.nasa.gov/mission_pages/GLAST/news/smokestack-plumes.html NASA Goddard Space Flight Center is home to the nation's largest organization of combined scientists, engineers and technologists that build spacecraft, instruments and new technology to study the Earth, the sun, our solar system, and the universe.

Failure Investigation & Design Optimization of a Photo-Multiplier Tube Assembly Under Thermal Loading

NASA Technical Reports Server (NTRS)

Dahya, Kevin

2004-01-01

Analysis of GLAST ACD Photo-Multiplier Tube (PMT) assembly under thermal loading demonstrates that the glass tube experiences high stresses due to Coefficient of Thermal Expansion mismatch, as well as increased stress due to high stiffness and incompressibility of potting compound. Further investigation shows adverse loading effects due to the magnetic shield, a thin piece of steel wrapped around the PMT. This steel, Mu Metal, contained an overlap region that directly attributed to crack propagation in the outside surface of the tube. Sensitivities to different configurations were studied to reduce the stress and provide a more uniform loading throughout the PMT to ensure mission success. Studies indicate substituting a softer and more compressible potting compound and moving the Mu metal from the glass tube to the outside wall of the aluminum housing yields lower stress.

Elevated systemic glutamic acid level in the non-obese diabetic mouse is Idd linked and induces beta cell apoptosis.

PubMed

Banday, Viqar Showkat; Lejon, Kristina

2017-02-01

Although type 1 diabetes (T1D) is a T-cell-mediated disease in the effector stage, the mechanism behind the initial beta cell assault is less understood. Metabolomic differences, including elevated levels of glutamic acid, have been observed in patients with T1D before disease onset, as well as in pre-diabetic non-obese diabetic (NOD) mice. Increased levels of glutamic acid damage both neurons and beta cells, implying that this could contribute to the initial events of T1D pathogenesis. We investigated the underlying genetic factors and consequences of the increased levels of glutamic acid in NOD mice. Serum glutamic acid levels from a (NOD×B6)F 2 cohort (n = 182) were measured. By genome-wide and Idd region targeted microsatellite mapping, genetic association was detected for six regions including Idd2, Idd4 and Idd22. In silico analysis of potential enzymes and transporters located in and around the mapped regions that are involved in glutamic acid metabolism consisted of alanine aminotransferase, glutamic-oxaloacetic transaminase, aldehyde dehydrogenase 18 family, alutamyl-prolyl-tRNA synthetase, glutamic acid transporters GLAST and EAAC1. Increased EAAC1 protein expression was observed in lysates from livers of NOD mice compared with B6 mice. Functional consequence of the elevated glutamic acid level in NOD mice was tested by culturing NOD. Rag2 -/- Langerhans' islets with glutamic acid. Induction of apoptosis of the islets was detected upon glutamic acid challenge using TUNEL assay. Our results support the notion that a dysregulated metabolome could contribute to the initiation of T1D. We suggest that targeting of the increased glutamic acid in pre-diabetic patients could be used as a potential therapy. © 2016 John Wiley & Sons Ltd.

Tycho's Star Shines in Gamma Rays

NASA Image and Video Library

2017-12-08

NASA image relase December 13, 2011 Gamma-rays detected by Fermi's LAT show that the remnant of Tycho's supernova shines in the highest-energy form of light. This portrait of the shattered star includes gamma rays (magenta), X-rays (yellow, green, and blue), infrared (red) and optical data. Credit: Gamma ray, NASA/DOE/Fermi LAT Collaboration; X-ray, NASA/CXC/SAO; Infrared, NASA/JPL-Caltech; Optical, MPIA, Calar Alto, O. Krause et al. and DSS To read more go to: www.nasa.gov/mission_pages/GLAST/news/tycho-star.html NASA image use policy. NASA Goddard Space Flight Center enables NASA’s mission through four scientific endeavors: Earth Science, Heliophysics, Solar System Exploration, and Astrophysics. Goddard plays a leading role in NASA’s accomplishments by contributing compelling scientific knowledge to advance the Agency’s mission. Follow us on Twitter Like us on Facebook Find us on Instagram

The Supercritical Pile Model: Prompt Emission Across the Electromagnetic Spectrum

NASA Technical Reports Server (NTRS)

Kazanas, Demos; Mastichiadis, A.

2008-01-01

The "Supercritical Pile" GRB model is an economical model that provides the dissipation necessary to convert explosively the energy stored in relativistic protons in the blast wave of a GRB into radiation; at the same time it produces spectra whose luminosity peaks at 1 MeV in the lab frame, the result of the kinematics of the proton-photon - pair production reaction that effects the conversion of proton energy to radiation. We outline the fundamental notions behind the "Supercritical Pile" model and discuss the resulting spectra of the prompt emission from optical to gamma-ray energies of order Gamma^2 m_ec^2, (Gamma is the Lorentz factor of the blast wave) present even in the absence of an accelerated particle distribution and compare our results to bursts that cover this entire energy range. Particular emphasis is given on the emission at the GLAST energy range both in the prompt and the afterglow stages of the burst.

Astrocyte deletion of Bmal1 alters daily locomotor activity and cognitive functions via GABA signalling

PubMed Central

Barca-Mayo, Olga; Pons-Espinal, Meritxell; Follert, Philipp; Armirotti, Andrea; Berdondini, Luca; De Pietri Tonelli, Davide

2017-01-01

Circadian rhythms are controlled by a network of clock neurons in the central pacemaker, the suprachiasmatic nucleus (SCN). Core clock genes, such as Bmal1, are expressed in SCN neurons and in other brain cells, such as astrocytes. However, the role of astrocytic clock genes in controlling rhythmic behaviour is unknown. Here we show that ablation of Bmal1 in GLAST-positive astrocytes alters circadian locomotor behaviour and cognition in mice. Specifically, deletion of astrocytic Bmal1 has an impact on the neuronal clock through GABA signalling. Importantly, pharmacological modulation of GABAA-receptor signalling completely rescues the behavioural phenotypes. Our results reveal a crucial role of astrocytic Bmal1 for the coordination of neuronal clocks and propose a new cellular target, astrocytes, for neuropharmacology of transient or chronic perturbation of circadian rhythms, where alteration of astrocytic clock genes might contribute to the impairment of the neurobehavioural outputs such as cognition. PMID:28186121

A celestial gamma-ray foreground due to the albedo of small solar system bodies and a remote probe of the interstellar cosmic ray spectrum

DOE Office of Scientific and Technical Information (OSTI.GOV)

Moskalenko, Igor V.; Porter, Troy A.; Digel, Seth W.

2007-12-17

We calculate the {gamma}-ray albedo flux from cosmic-ray (CR) interactions with the solid rock and ice in Main Belt asteroids and Kuiper Belt objects (KBOs) using the Moon as a template. We show that the {gamma}-ray albedo for the Main Belt and Kuiper Belt strongly depends on the small-body mass spectrum of each system and may be detectable by the forthcoming Gamma Ray Large Area Space Telescope (GLAST). The orbits of the Main Belt asteroids and KBOs are distributed near the ecliptic, which passes through the Galactic center and high Galactic latitudes. If detected, the {gamma}-ray emission by the Mainmore » Belt and Kuiper Belt has to be taken into account when analyzing weak {gamma}-ray sources close to the ecliptic, especially near the Galactic center and for signals at high Galactic latitudes, such as the extragalactic {gamma}-ray emission. Additionally, it can be used to probe the spectrum of CR nuclei at close-to-interstellar conditions, and the mass spectrum of small bodies in the Main Belt and Kuiper Belt. The asteroid albedo spectrum also exhibits a 511 keV line due to secondary positrons annihilating in the rock. This may be an important and previously unrecognized celestial foreground for the INTErnational Gamma-Ray Astrophysics Laboratory (INTEGRAL) observations of the Galactic 511 keV line emission including the direction of the Galactic center.« less

The potential of a Čerenkov Array for Supersymmetry and Cosmology

NASA Astrophysics Data System (ADS)

Vasileiadis, G.; Falvard, A.; Giraud, E.; Lavalle, J.; Sajjad, S.

2005-02-01

If R-parity is sufficiently well conserved, most of the supersymmetric models predict the existence of a stable, neutral particle, the neutralino, which would be a natural candidate for dark matter. Such particles can annihilate through various channels producing in particular, a faint flux of high energy photons in galactic and extragalactic high density regions. We have considered the potential of a Čerenkov array for exploring a significant fraction of the supersymmetric parameter space. The main constraints are the flux limit, which requires a very large effective area, and the energy threshold which needs reaching lower limit of the order of 15-20 GeV due to the lowest neutralino mass given by accelerators. Combining such constaints leads to an array of at least 16-19 Čerenkov reflectors with diameters of the order of 18m, located at high altitude (5000 m). This instrument would combine wide angle camera and large detection areas. It would also serve as a major tool in Observational Cosmology and Astrophysics above 15-20 GeV up to 1 TeV. Coming after GLAST, it would allow studying in details, at higher energy, the sources detected by this satellite. This instrument would not be able to explore the 10 GeV to sub-10 GeV domain unless higher QE detectors are discovered or larger diameters are considered. A very interesting site would be the Chajnantor-Toco area for this project which requires clear UBV photometric nights.

Ultrahigh energy neutrinos from Centaurus A and the Auger hot spot

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cuoco, A.; Hannestad, S.

2008-07-15

The Pierre Auger Collaboration has reported a correlation between ultrahigh energy cosmic rays (UHECR) and nearby active galactic nuclei (AGN) within {approx}75 Mpc. Two of these events fall within 3 degrees from Centaurus A (Cen A), the nearest AGN, clearly suggesting that this object is a strong UHECR emitter. Here we pursue this hypothesis and forecast the expected rate of ultrahigh energy neutrinos in detectors like IceCube. In our baseline model we find a rate of {approx}0.4-0.6 yr{sup -1} events above a threshold of 100 TeV, the uncertainty of which is mainly related to the poor knowledge of the physicalmore » parameters of the source and details of the model. This situation will improve with detailed high energy gamma ray measurements of Cen A by the upcoming Gamma Ray Large Area Space Telescope (GLAST) satellite. This would make Cen A the first example where the potential of high energy multimessenger astronomy is finally realized.« less

NASA Strategic Roadmap: Origin, Evolution, Structure, and Destiny of the Universe

NASA Technical Reports Server (NTRS)

White, Nicholas E.

2005-01-01

The NASA strategic roadmap on the Origin, Evolution, Structure and Destiny of the Universe is one of 13 roadmaps that outline NASA s approach to implement the vision for space exploration. The roadmap outlines a program to address the questions: What powered the Big Bang? What happens close to a Black Hole? What is Dark Energy? How did the infant universe grow into the galaxies, stars and planets, and set the stage for life? The roadmap builds upon the currently operating and successful missions such as HST, Chandra and Spitzer. The program contains two elements, Beyond Einstein and Pathways to Life, performed in three phases (2005-2015, 2015-2025 and >2025) with priorities set by inputs received from reviews undertaken by the National Academy of Sciences and technology readiness. The program includes the following missions: 2005-2015 GLAST, JWST and LISA; 2015-2025 Constellation-X and a series of Einstein Probes; and >2025 a number of ambitious vision missions which will be prioritized by results from the previous two phases.

Pulsed Gamma Rays from the Millisecond Pulsar J0030+0451 with the Fermi Large Area Telescope

DOE PAGES

Abdo, A. A.; Ackermann, M.; Atwood, W. B.; ...

2009-06-19

In this paper, we report the discovery of gamma-ray pulsations from the nearby isolated millisecond pulsar (MSP) PSR J0030+0451 with the Large Area Telescope on the Fermi Gamma-ray Space Telescope (formerly GLAST). This discovery makes PSR J0030+0451 the second MSP to be detected in gamma rays after PSR J0218+4232, observed by the EGRET instrument on the Compton Gamma-Ray Observatory. The spin-down power E(dotabove) = 3.5 x 10 33 erg s -1 is an order of magnitude lower than the empirical lower bound of previously known gamma-ray pulsars. The emission profile is characterized by two narrow peaks, 0.07 ± 0.01 andmore » 0.08 ± 0.02 wide, respectively, separated by 0.44 ± 0.02 in phase. The first gamma-ray peak falls 0.15 ± 0.01 after the main radio peak. The pulse shape is similar to that of the "normal" gamma-ray pulsars. An exponentially cutoff power-law fit of the emission spectrum leads to an integral photon flux above 100 MeV of (6.76 ± 1.05 ± 1.35) × 10 –8 cm –2 s –1 with cutoff energy (1.7 ± 0.4 ± 0.5) GeV. Finally, based on its parallax distance of (300 ± 90) pc, we obtain a gamma-ray efficiency L γ/E(dotabove) ≃ 15% for the conversion of spin-down energy rate into gamma-ray radiation, assuming isotropic emission.« less

Hippocampal Astrocyte Cultures from Adult and Aged Rats Reproduce Changes in Glial Functionality Observed in the Aging Brain.

PubMed

Bellaver, Bruna; Souza, Débora Guerini; Souza, Diogo Onofre; Quincozes-Santos, André

2017-05-01

Astrocytes are dynamic cells that maintain brain homeostasis, regulate neurotransmitter systems, and process synaptic information, energy metabolism, antioxidant defenses, and inflammatory response. Aging is a biological process that is closely associated with hippocampal astrocyte dysfunction. In this sense, we demonstrated that hippocampal astrocytes from adult and aged Wistar rats reproduce the glial functionality alterations observed in aging by evaluating several senescence, glutamatergic, oxidative and inflammatory parameters commonly associated with the aging process. Here, we show that the p21 senescence-associated gene and classical astrocyte markers, such as glial fibrillary acidic protein (GFAP), vimentin, and actin, changed their expressions in adult and aged astrocytes. Age-dependent changes were also observed in glutamate transporters (glutamate aspartate transporter (GLAST) and glutamate transporter-1 (GLT-1)) and glutamine synthetase immunolabeling and activity. Additionally, according to in vivo aging, astrocytes from adult and aged rats showed an increase in oxidative/nitrosative stress with mitochondrial dysfunction, an increase in RNA oxidation, NADPH oxidase (NOX) activity, superoxide levels, and inducible nitric oxide synthase (iNOS) expression levels. Changes in antioxidant defenses were also observed. Hippocampal astrocytes also displayed age-dependent inflammatory response with augmentation of proinflammatory cytokine levels, such as TNF-α, IL-1β, IL-6, IL-18, and messenger RNA (mRNA) levels of cyclo-oxygenase 2 (COX-2). Furthermore, these cells secrete neurotrophic factors, including glia-derived neurotrophic factor (GDNF), brain-derived neurotrophic factor (BDNF), S100 calcium-binding protein B (S100B) protein, and transforming growth factor-β (TGF-β), which changed in an age-dependent manner. Classical signaling pathways associated with aging, such as nuclear factor erythroid-derived 2-like 2 (Nrf2), nuclear factor kappa B (NFκB), heme oxygenase-1 (HO-1), and p38 mitogen-activated protein kinase (MAPK), were also changed in adult and aged astrocytes and are probably related to the changes observed in senescence marker, glutamatergic metabolism, mitochondrial dysfunction, oxidative/nitrosative stress, antioxidant defenses, inflammatory response, and trophic factors release. Together, our results reinforce the role of hippocampal astrocytes as a target for understanding the mechanisms involved in aging and provide an innovative tool for studies of astrocyte roles in physiological and pathological aging brain.

Ten-year optical monitoring of PKS 0735+178: historical comparison, multiband behavior, and variability timescales

NASA Astrophysics Data System (ADS)

Ciprini, S.; Takalo, L. O.; Tosti, G.; Raiteri, C. M.; Fiorucci, M.; Villata, M.; Nucciarelli, G.; Lanteri, L.; Nilsson, K.; Ros, J. A.

2007-05-01

Aims:New data and results on the optical behavior of the prominent blazar PKS 0735+178 (also known as OI 158, S3 0735+17, DA 237, 1ES 0735+178, 3EG J0737+1721) are presented, through the most continuous BVRI data available in the period 1994-2004 (about 500 nights of observations). In addition, the whole historical light curve, and a new photometric calibration of comparison stars in the field of this source are reported. Methods: Several methods for time series analysis of sparse data sets are developed, adapted, and applied to the reconstructed historical light curve and to each observing season of our unpublished optical database on PKS 0735+178. Optical spectral indexes are calculated from the multi-band observations and studied on long-term (years) durations as well. For the first time in this source, variability modes, characteristic timescales, and the signal power spectrum are explored and identified over 3 decades in time with sufficient statistics. The novel investigation of mid-term optical scales (days, weeks), could be also applied and compared to blazar gamma-ray light curves that will be provided, on the same timescales, by the forthcoming GLAST observatory. Results: In the last 10 years the optical emission of PKS 0735+178 exhibited a rather achromatic behavior and a variability mode resembling the shot-noise. The source was at an intermediate or low brightness level, showing a mild flaring activity and a superimposition/succession of rapid and slower flares, without extraordinary and isolated outbursts, but, at any rate, characterized by one major active phase in 2001. Several mid-term scales of variability were found, the more common falling into duration intervals of about 27-28 days, 50-56 days and 76-79 days. Rapid variability in the historical light curve appears to be modulated by a general, slower, and rather oscillating temporal trend, where typical amplitudes of about 4.5, 8.5, and 11-13 years can be identified. This spectral and temporal analysis, accompanying our data publication, suggests the occurrence of distinctive signatures at mid-term durations that can likely be of transitory nature. On the other hand the possible pseudo-cyclical or multi-component modulations at long times could be more stable, recurrent and correlated to the bimodal radio flux behavior and the twisted radio structure observed over several years in this blazar.

Antimatter cosmic rays from dark matter annihilation: First results from an N-body experiment

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lavalle, J.; Nezri, E.; Athanassoula, E.

2008-11-15

While the particle hypothesis for dark matter may be very soon investigated at the LHC, and as the PAMELA and GLAST satellites are currently taking new data on charged and gamma cosmic rays, the need of controlling the theoretical uncertainties affecting the possible indirect signatures of dark matter annihilation is of paramount importance. The uncertainties which originate from the dark matter distribution are difficult to estimate because current astrophysical observations provide rather weak dynamical constraints and because, according to cosmological N-body simulations, dark matter is neither smoothly nor spherically distributed in galactic halos. Some previous studies made use of N-bodymore » simulations to compute the {gamma}-ray flux from dark matter annihilation, but such a work has never been performed for the antimatter (positron and antiproton) primary fluxes, for which transport processes complicate the calculations. We take advantage of the galaxylike 3D dark matter map extracted from the Horizon Project results to calculate the positron and antiproton fluxes from dark matter annihilation, in a model-independent approach as well as for dark matter particle benchmarks relevant at the LHC scale (from supersymmetric and extradimensional theories). We find that the flux uncertainties arise mainly from fluctuations of the local dark matter density, and are of {approx}1 order of magnitude. We compare our results to analytic descriptions of the dark matter halo, showing how the latter can well reproduce the former. The overall antimatter predictions associated with our benchmark models are shown to lie far below the existing measurements and, in particular, that of the positron fraction recently reported by PAMELA, and far below the background predictions as well. Finally, we stress the limits of the use of an N-body framework in this context.« less

Oct4 Methylation-Mediated Silencing As an Epigenetic Barrier Preventing Müller Glia Dedifferentiation in a Murine Model of Retinal Injury.

PubMed

Reyes-Aguirre, Luis I; Lamas, Monica

2016-01-01

Müller glia (MG) is the most abundant glial type in the vertebrate retina. Among its many functions, it is capable of responding to injury by dedifferentiating, proliferating, and differentiating into every cell types lost to damage. This regenerative ability is notoriously absent in mammals. We have previously reported that cultured mammalian MG undergoes a partial dedifferentiation, but fails to fully acquire a progenitor phenotype and differentiate into neurons. This might be explained by a mnemonic mechanism comprised by epigenetic traits, such as DNA methylation. To achieve a better understanding of this epigenetic memory, we studied the expression of pluripotency-associated genes, such as Oct4, Nanog , and Lin28 , which have been reported as necessary for regeneration in fish, at early times after NMDA-induced retinal injury in a mouse experimental model. We found that although Oct4 is expressed rapidly after damage (4 hpi), it is silenced at 24 hpi. This correlates with a significant decrease in the DNA methyltransferase Dnmt3b expression, which returns to basal levels at 24 hpi. By MS-PCR, we observed a decrease in Oct4 methylation levels at 4 and 12 hpi, before returning to a fully methylated state at 24 hpi. To demonstrate that these changes are restricted to MG, we separated these cells using a GLAST antibody coupled with magnetic beads. Finally, intravitreous administration of the DNA-methyltransferase inhibitor SGI-1027 induced Oct4 expression at 24 hpi in MG. Our results suggest that mammalian MG injury-induced dedifferentiation could be restricted by DNA methylation, which rapidly silences Oct4 expression, preventing multipotency acquisition.

Oct4 Methylation-Mediated Silencing As an Epigenetic Barrier Preventing Müller Glia Dedifferentiation in a Murine Model of Retinal Injury

PubMed Central

Reyes-Aguirre, Luis I.; Lamas, Monica

2016-01-01

Müller glia (MG) is the most abundant glial type in the vertebrate retina. Among its many functions, it is capable of responding to injury by dedifferentiating, proliferating, and differentiating into every cell types lost to damage. This regenerative ability is notoriously absent in mammals. We have previously reported that cultured mammalian MG undergoes a partial dedifferentiation, but fails to fully acquire a progenitor phenotype and differentiate into neurons. This might be explained by a mnemonic mechanism comprised by epigenetic traits, such as DNA methylation. To achieve a better understanding of this epigenetic memory, we studied the expression of pluripotency-associated genes, such as Oct4, Nanog, and Lin28, which have been reported as necessary for regeneration in fish, at early times after NMDA-induced retinal injury in a mouse experimental model. We found that although Oct4 is expressed rapidly after damage (4 hpi), it is silenced at 24 hpi. This correlates with a significant decrease in the DNA methyltransferase Dnmt3b expression, which returns to basal levels at 24 hpi. By MS-PCR, we observed a decrease in Oct4 methylation levels at 4 and 12 hpi, before returning to a fully methylated state at 24 hpi. To demonstrate that these changes are restricted to MG, we separated these cells using a GLAST antibody coupled with magnetic beads. Finally, intravitreous administration of the DNA-methyltransferase inhibitor SGI-1027 induced Oct4 expression at 24 hpi in MG. Our results suggest that mammalian MG injury-induced dedifferentiation could be restricted by DNA methylation, which rapidly silences Oct4 expression, preventing multipotency acquisition. PMID:27895551

Warming rays in cluster cool cores

NASA Astrophysics Data System (ADS)

Colafrancesco, S.; Marchegiani, P.

2008-06-01

Context: Cosmic rays are confined in the atmospheres of galaxy clusters and, therefore, they can play a crucial role in the heating of their cool cores. Aims: We discuss here the thermal and non-thermal features of a model of cosmic ray heating of cluster cores that can provide a solution to the cooling-flow problems. To this aim, we generalize a model originally proposed by Colafrancesco, Dar & DeRujula (2004) and we show that our model predicts specific correlations between the thermal and non-thermal properties of galaxy clusters and enables various observational tests. Methods: The model reproduces the observed temperature distribution in clusters by using an energy balance condition in which the X-ray energy emitted by clusters is supplied, in a quasi-steady state, by the hadronic cosmic rays, which act as “warming rays” (WRs). The temperature profile of the intracluster (IC) gas is strictly correlated with the pressure distribution of the WRs and, consequently, with the non-thermal emission (radio, hard X-ray and gamma-ray) induced by the interaction of the WRs with the IC gas and the IC magnetic field. Results: The temperature distribution of the IC gas in both cool-core and non cool-core clusters is successfully predicted from the measured IC plasma density distribution. Under this contraint, the WR model is also able to reproduce the thermal and non-thermal pressure distribution in clusters, as well as their radial entropy distribution, as shown by the analysis of three clusters studied in detail: Perseus, A2199 and Hydra. The WR model provides other observable features of galaxy clusters: a correlation of the pressure ratio (WRs to thermal IC gas) with the inner cluster temperature (P_WR/P_th) ˜ (kT_inner)-2/3, a correlation of the gamma-ray luminosity with the inner cluster temperature Lγ ˜ (kT_inner)4/3, a substantial number of cool-core clusters observable with the GLAST-LAT experiment, a surface brightness of radio halos in cool-core clusters that recovers the observed one, a hard X-ray ICS emission from cool-core clusters that is systematically lower than the observed limits and yet observable with the next generation high-sensitivity and spatial resolution HXR experiments like Simbol-X. Conclusions: The specific theoretical properties and the multi-frequency distribution of the e.m. signals predicted in the WR model render it quite different from the other models so far proposed for the heating of clusters' cool-cores. Such differences make it possible to prove or disprove our model as an explanation for the cooling-flow problems on the basis of multi-frequency observations of galaxy clusters.

Astronomical Surveys, Catalogs, Databases, and Archives

NASA Astrophysics Data System (ADS)

Mickaelian, A. M.

2016-06-01

All-sky and large-area astronomical surveys and their cataloged data over the whole range of electromagnetic spectrum are reviewed, from γ-ray to radio, such as Fermi-GLAST and INTEGRAL in γ-ray, ROSAT, XMM and Chandra in X-ray, GALEX in UV, SDSS and several POSS I and II based catalogues (APM, MAPS, USNO, GSC) in optical range, 2MASS in NIR, WISE and AKARI IRC in MIR, IRAS and AKARI FIS in FIR, NVSS and FIRST in radio and many others, as well as most important surveys giving optical images (DSS I and II, SDSS, etc.), proper motions (Tycho, USNO, Gaia), variability (GCVS, NSVS, ASAS, Catalina, Pan-STARRS) and spectroscopic data (FBS, SBS, Case, HQS, HES, SDSS, CALIFA, GAMA). Most important astronomical databases and archives are reviewed as well, including Wide-Field Plate DataBase (WFPDB), ESO, HEASARC, IRSA and MAST archives, CDS SIMBAD, VizieR and Aladin, NED and HyperLEDA extragalactic databases, ADS and astro-ph services. They are powerful sources for many-sided efficient research using Virtual Observatory tools. Using and analysis of Big Data accumulated in astronomy lead to many new discoveries.

Differential cellular and subcellular distribution of glutamate transporters in the cat retina.

PubMed

Fyk-Kolodziej, Bozena; Qin, Pu; Dzhagaryan, Arturik; Pourcho, Roberta G

2004-01-01

Retrieval of glutamate from extracellular sites in the retina involves at least five excitatory amino acid transporters. Immunocytochemical analysis of the cat retina indicates that each of these transporters exhibits a selective distribution which may reflect its specific function. The uptake of glutamate into Muller cells or astrocytes appears to depend upon GLAST and EAAT4, respectively. Staining for EAAT4 was also seen in the pigment epithelium. The remaining transporters are neuronal with GLT-1alpha localized to a number of cone bipolar, amacrine, and ganglion cells and GLT-1v in cone photoreceptors and several populations of bipolar cells. The EAAC1 transporter was found in horizontal, amacrine, and ganglion cells. Staining for EAAT5 was seen in the axon terminals of both rod and cone photoreceptors as well as in numerous amacrine and ganglion cells. Although some of the glutamate transporter molecules are positioned for presynaptic or postsynaptic uptake at glutamatergic synapses, others with localizations more distant from such contacts may serve in modulatory roles or provide protection against excitoxic or oxidative damage.

Cassiopeia A supernova

NASA Image and Video Library

2017-12-08

NASA's Fermi Closes on Source of Cosmic Rays New images from NASA's Fermi Gamma-ray Space Telescope show where supernova remnants emit radiation a billion times more energetic than visible light. The images bring astronomers a step closer to understanding the source of some of the universe's most energetic particles -- cosmic rays. This composite shows the Cassiopeia A supernova remnant across the spectrum: Gamma rays (magenta) from NASA's Fermi Gamma-ray Space Telescope; X-rays (blue, green) from NASA's Chandra X-ray Observatory; visible light (yellow) from the Hubble Space Telescope; infrared (red) from NASA's Spitzer Space Telescope; and radio (orange) from the Very Large Array near Socorro, N.M. Credit: NASA/DOE/Fermi LAT Collaboration, CXC/SAO/JPL-Caltech/Steward/O. Krause et al., and NRAO/AUI For more information: www.nasa.gov/mission_pages/GLAST/news/cosmic-rays-source.... NASA Goddard Space Flight Center is home to the nation's largest organization of combined scientists, engineers and technologists that build spacecraft, instruments and new technology to study the Earth, the sun, our solar system, and the universe. Follow us on Twitter Join us on Facebook

Defining the Cellular Environment in the Organ of Corti following Extensive Hair Cell Loss: A Basis for Future Sensory Cell Replacement in the Cochlea

PubMed Central

Taylor, Ruth R.; Jagger, Daniel J.; Forge, Andrew

2012-01-01

Background Following the loss of hair cells from the mammalian cochlea, the sensory epithelium repairs to close the lesions but no new hair cells arise and hearing impairment ensues. For any cell replacement strategy to be successful, the cellular environment of the injured tissue has to be able to nurture new hair cells. This study defines characteristics of the auditory sensory epithelium after hair cell loss. Methodology/Principal Findings Studies were conducted in C57BL/6 and CBA/Ca mice. Treatment with an aminoglycoside-diuretic combination produced loss of all outer hair cells within 48 hours in both strains. The subsequent progressive tissue re-organisation was examined using immunohistochemistry and electron microscopy. There was no evidence of significant de-differentiation of the specialised columnar supporting cells. Kir4.1 was down regulated but KCC4, GLAST, microtubule bundles, connexin expression patterns and pathways of intercellular communication were retained. The columnar supporting cells became covered with non-specialised cells migrating from the outermost region of the organ of Corti. Eventually non-specialised, flat cells replaced the columnar epithelium. Flat epithelium developed in distributed patches interrupting regions of columnar epithelium formed of differentiated supporting cells. Formation of the flat epithelium was initiated within a few weeks post-treatment in C57BL/6 mice but not for several months in CBA/Ca's, suggesting genetic background influences the rate of re-organisation. Conclusions/Significance The lack of dedifferentiation amongst supporting cells and their replacement by cells from the outer side of the organ of Corti are factors that may need to be considered in any attempt to promote endogenous hair cell regeneration. The variability of the cellular environment along an individual cochlea arising from patch-like generation of flat epithelium, and the possible variability between individuals resulting from genetic influences on the rate at which remodelling occurs may pose challenges to devising the appropriate regenerative therapy for a deaf patient. PMID:22299045

Increased Dynamics of Tricarboxylic Acid Cycle and Glutamate Synthesis in Obese Adipose Tissue

PubMed Central

Nagao, Hirofumi; Nishizawa, Hitoshi; Bamba, Takeshi; Nakayama, Yasumune; Isozumi, Noriyoshi; Nagamori, Shushi; Kanai, Yoshikatsu; Tanaka, Yoshimitsu; Kita, Shunbun; Fukuda, Shiro; Funahashi, Tohru; Maeda, Norikazu; Fukusaki, Eiichiro; Shimomura, Iichiro

2017-01-01

Obesity is closely associated with various metabolic disorders. However, little is known about abnormalities in the metabolic change of obese adipose tissue. Here we use static metabolic analysis and in vivo metabolic turnover analysis to assess metabolic dynamics in obese mice. The static metabolic analyses showed that glutamate and constitutive metabolites of the TCA cycle were increased in the white adipose tissue (WAT) of ob/ob and diet-induced obesity mice but not in the liver or skeletal muscle of these obese mice. Moreover, in vivo metabolic turnover analyses demonstrated that these glucose-derived metabolites were dynamically and specifically produced in obese WAT compared with lean WAT. Glutamate rise in obese WAT was associated with down-regulation of glutamate aspartate transporter (GLAST), a major glutamate transporter for adipocytes, and low uptake of glutamate into adipose tissue. In adipocytes, glutamate treatment reduced adiponectin secretion and insulin-mediated glucose uptake and phosphorylation of Akt. These data suggest that a high intra-adipocyte glutamate level potentially relates to adipocyte dysfunction in obesity. This study provides novel insights into metabolic dysfunction in obesity through comprehensive application of in vivo metabolic turnover analysis in two obese animal models. PMID:28119455

Social Network Infiltration

NASA Astrophysics Data System (ADS)

Plait, Philip

2008-05-01

Social networks are websites (or software that distributes media online) where users can distribute content to either a list of friends on that site or to anyone who surfs onto their page, and where those friends can interact and discuss the content. By linking to friends online, the users’ personal content (pictures, songs, favorite movies, diaries, websites, and so on) is dynamically distributed, and can "become viral", that is, get spread rapidly as more people see it and spread it themselves. Social networks are immensely popular around the planet, especially with younger users. The biggest social networks are Facebook and MySpace; an IYA2009 user already exists on Facebook, and one will be created for MySpace (in fact, several NASA satellites such as GLAST and Swift already have successful MySpace pages). Twitter is another network where data distribution is more limited; it is more like a mini-blog, but is very popular. IYA2009 already has a Twitter page, and will be updated more often with relevant information. In this talk I will review the existing social networks, show people how and why they are useful, and give them the tools they need to contribute meaningfully to IYA's online reach.

Non-Quiescent X-ray Emission from Neutron Stars and Black Holes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tournear, Derek M

X-ray astronomy began with the detection of the persistent source Scorpius X-1. Shortly afterwards, sources were detected that were variable. Centaurus X-2, was determined to be an X-ray transient, having a quiescent state, and a state that was much brighter. As X-ray astronomy progressed, classifications of transient sources developed. One class of sources, believed to be neutron stars, undergo extreme luminosity transitions lasting a few seconds. These outbursts are believed to be thermonuclear explosions occurring on the surface of neutron stars (type I X-ray bursts). Other sources undergo luminosity changes that cannot be explained by thermonuclear burning and last formore » days to months. These sources are soft X-ray transients (SXTs) and are believed to be the result of instabilities in the accretion of matter onto either a neutron star or black hole. Type I X-ray bursts provide a tool for probing the surfaces of neutron stars. Requiring a surface for the burning has led authors to use the presence of X-ray bursts to rule out the existence of a black hole (where an event horizon exists not a surface) for systems which exhibit type I X-ray bursts. Distinguishing between neutron stars and black holes has been a problem for decades. Narayan and Heyl have developed a theoretical framework to convert suitable upper limits on type I X-ray bursts from accreting black hole candidates (BHCs) into evidence for an event horizon. We survey 2101.2 ks of data from the USA X-ray timing experiment and 5142 ks of data from the Rossi X-ray Timing Explorer (RXTE) experiment to obtain the first formal constraint of this type. 1122 ks of neutron star data yield a population averaged mean burst rate of 1.7 {+-} 0.4 x 10{sup -5} bursts s{sup -1}, while 6081 ks of BHC data yield a 95% confidence level upper limit of 4.9 x 10{sup -7} bursts s{sup -1}. Applying the framework of Narayan and Heyl we calculate regions of luminosity where the neutron stars are expected to burst and the BHCs would be expected to burst if they had a similar surface. In this luminosity region 464 ks of neutron star data yield an averaged mean burst rate of 4.1 {+-} 0.9 x 10{sup -5} bursts s{sup -1}, and 1512 ks of BHC data yield a 95% confidence level upper limit of 2.0 x 10{sup -6} bursts s{sup -1} and a strong limit that BHCs do not burst with a rate similar to the rate of neutron stars in these regions. This gives evidence that BHCs do not have surfaces. In addition to studying type I X-ray bursts, we analyzed the SXT behavior. In particular, 4U 1630-47, was analyzed throughout its 1999 outburst. This source is one of the oldest known SXTs. This source is assumed to be a BHC in a low-mass X-ray binary system. Despite the length of time devoted to studying this source, there is still little known about it. We report the results of timing and spectral analysis on the 1999 outburst, and compare these results to other outbursts of 4U 1630-47. We found this source progressed from a low-hard state to a high-soft state and then rapidly transitioned back into the low-hard state before returning to quiescence. Timing analysis detected a low frequency quasi-periodic oscillation (LFQPO) during the initial rise of the outburst, which disappeared and did not return. The variability in the X-ray flux in the 0.1-2000 Hz frequency range is low during the high state, but increases as the source progresses into the low-hard state. The next generation Gamma Ray Large Area Space Telescope (GLAST), will measure astrophysical phenomena in the 20 MeV--a few TeV energy range. We describe preliminary design and testing of GLAST. The detector is based on a silicon tracker with similar design characteristics of vertex detectors used in high-energy physics experiments at accelerator based facilities. A beam test engineering model was designed, constructed, and tested at SLAC in 1999-2000. We describe this test, and discuss how the results from this test can improve and demonstrate the viability of the GLAST technology.« less

Obituary: Herbert Gursky, 1930-2006

NASA Astrophysics Data System (ADS)

Doschek, George; Dahlburg, Jill

2007-12-01

Dr. Herbert Gursky, Acting Associate Director of Research for the Naval Research Laboratory's (NRL's) Systems Directorate, and formerly Superintendent of the Space Science Division and Chief Scientist of the E. O. Hulburt Center for Space Research. Dr. Gursky died following a long illness on late Friday afternoon, December 1, 2006. Dr. Gursky was a great friend, valued colleague, and distinguished researcher who will be missed greatly. Dr. Gursky was born in Bronx, New York, on May 27, 1930. He was educated in secondary schools in Miami, Florida, and received a Bachelor's Degree from the University of Florida in 1951. He did graduate work in physics at Vanderbilt University (Master's degree in 1953) and Princeton University (Doctorate degree in 1959). His first professional position was at Columbia University as an instructor in the Physics Department from 1958 to 1961. In 1961, he joined American Science and Engineering, Inc. (AS&E) in Cambridge, Massachusetts, as a senior scientist and rose to the position of Vice President, Space Research in 1967. In 1973 he joined the Smithsonian Astrophysical Observatory (SAO) as a supervisory astrophysicist. In 1974, Dr. Gursky was appointed Professor in the Practice of Astronomy at Harvard University and in 1976 was named Associate Director of the Center for Astrophysics for the Division of Optical and Infrared Astronomy. In 1981, Dr. Gursky joined NRL as Superintendent of its Space Science Division and Chief Scientist of the E. O. Hulburt Center for Space Research. He moved to the position of Acting Associate Director of Research for NRL's Systems Directorate in 2006. Dr. Gursky's primary research interests were in the area of X-ray astronomy. He published more than 100 articles in this area and edited two books on the subject. Before arriving at NRL, he was the principal investigator for NASA-sponsored space programs on the Astronomical Netherlands Satellite (ANS) and the High Energy Astrophysics Observatory (HEAO)-1 satellite, and a co-investigator on numerous other rocket and satellite experiments. At AS&E, Dr. Gursky managed research activities encompassing solar physics and magnetospheric research, and at SAO, he managed programs of ground-based astronomy and infrared astronomy. At SAO, he oversaw the completion of the Multiple Mirror Telescope, a joint program of SAO and the University of Arizona, comprising a 4.5-meter (equivalent) telescope of novel design that is situated at Mount Hopkins in Arizona. Dr. Gursky's work at NRL involved direction of a broad-ranging research effort involving about fifty Ph.D. scientists conducting investigations in the areas of high-energy astronomy, solar physics, solar terrestrial effects and atmospheric science. NRL is the corporate research laboratory for the Navy and has the responsibility for assuring that future Navy systems take full advantage of all available technology and scientific understandings. Dr. Gursky had the ability to distill and seize the most important nuggets from any research program and envision its application to a variety of new problems and directions. In numerous areas of atmospheric, solar and space science technology, Dr. Gursky recognized key scientific issues and their potential DoD applications. In solar physics, he spurred the development of semi-empirical modeling to predict solar storms that has been successfully transitioned to operational systems. He also supported participation in all NASA and other agency Sun-Earth connection orbiting space programs which resulted in a succession of spectacularly successful experiments in solar physics such as the high resolution rocket spectrograph and its flight on the NASA Spacelab 2, the Solar Ultraviolet Spectral Irradiance Monitor (SUSIM) on the NASA Upper Atmosphere Research Satellite, the Bragg crystal spectrometer solar flare experiment on the Japanese Yohkoh spacecraft, and the Large Angle and Spectrometric Coronagraph Experiment (LASCO) and extreme ultraviolet imaging telescope (EIT) on the ESA/NASA Solar and Heliospheric Observatory. These experiments have shed considerable light on how solar activity affects the near-Earth environment with many potential space weather applications. In high-energy astronomy, Dr. Gursky made many contributions. He provided scientific oversight for the Advanced Research and Global Observation Satellite (ARGOS) Space Test Program spacecraft that contained five NRL instruments: the Unconventional Stellar Aspect (USA) experiment, the Global Imaging Monitor of the Ionosphere (GIMI), the High Resolution Airglow/Aurora Spectroscopy (HIRAAS) experiment, the Extreme Ultraviolet Imaging Photometer (EUVIP), and the Coherent Electromagnetic Radio Tomography (CERTO) instrument. He continued his interest in X-ray astronomy with the USA experiment, which obtained observations of many celestial sources such as galactic binary X-ray sources and pulsars. Always with an eye toward applications, Dr. Gursky was interested in using X-ray sources, specifically X-ray pulsars, as precise clocks to provide spacecraft with autonomous timing and navigation. Dr. Gursky also supported research in gamma ray astrophysics, such as the development of NRL's Oriented Scintillation Spectrometer Experiment (OSSE) for the NASA Compton Gamma Ray Observatory (CGRO) satellite, and analysis of solar flare gamma ray spectra obtained from the NASA Solar Maximum Mission. In atmospheric science, Dr. Gursky particularly encouraged practical applications of basic research. He recognized the importance of remote sensing for space weather, which resulted in the development at NRL of operational ultraviolet sensors on Defense Meteorological Satellite Program (DMSP) spacecraft that are now providing environmental data products to the Air Force Space Weather Agency. He initiated a program in middle atmosphere research that has been enormously successful and has spawned numerous experimental and theoretical advances, such as the Middle Atmosphere High Resolution Spectrograph Investigation (MAHRSI) to measure trace constituents in the middle atmosphere such as the hydroxyl radical (OH). Dr. Gursky supported the development of theoretical middle atmosphere models such as the Mountain Wave Forecast Model that was used to predict flight conditions for allied aircraft during operations Southern Watch, Enduring Freedom, and Iraqi Freedom, which has been a boon to stratospheric flight operations over mountainous terrain. He also supported the HIRAAS experiment on ARGOS. Dr. Gursky provided outstanding leadership in the continued development of the United States space program. Under his stewardship, the NRL Space Science Division substantially expanded its leadership role in understanding the space environment and its effects on military and civilian systems. The Laboratory and the world are now witnessing the newest results of his scientific acumen and sound decision-making as exemplified in the very recent successful completions and launches of these major Space Science Division instruments: Delivery of GLAST LAT (September 2006): Delivery of the collaborative NRL Large Area Telescope (LAT) for the NASA Gamma Ray Large Area Space Telescope (GLAST) satellite integration; when deployed, GLAST will measure the most energetic processes in the universe — from X-ray bursts, black holes, neutron stars, and solar flares — and has the potential to discover previously unknown relics of the Big Bang; Launch of SOLAR-B (September 2006): The Japan Aerospace Exploration Agency's Hinode (Japanese for Sunrise, formerly known as SOLAR-B) launched September 23 carrying NRL's collaborative Extreme-ultraviolet Imaging Spectrometer (EIS), which achieved first light on October 28. EIS is now observing emission lines produced by highly ionized elements in the solar coronal and upper transition region of the Sun's atmosphere. Space Science Division scientists expect much exciting science concerning the coupling of solar activity to the near-Earth space environment to be produced by the EIS instrument; and, Launch of STEREO (October 2006): NASA's Solar Terrestrial Relations Observatory (STEREO) launched 25 October, carrying the collaborative NRL Sun-Earth Connection Coronal and Heliospheric Investigation (SECCHI) instruments suite, which is currently successfully functioning in the pre-commissioning phase. The instruments onboard STEREO's twin spacecraft will make observations to help NRL researchers construct the first-ever three-dimensional views of coronal mass ejections, vital data — in complement with the long-operational NRL-built NASA LASCO — for understanding how the Sun creates space weather Perhaps Dr. Gursky's most personal research successes were as a member of the group that made the discovery of cosmic X-ray sources in 1961, his work with sounding rockets that culminated in the optical identification of the bright X-ray source Scorpius X1 in 1966, his work on clusters of galaxies and the diffuse X-ray background from the Uhuru Satellite and the discovery of X-ray bursters on the ANS satellite.

Excitotoxicity Induced by Realgar in the Rat Hippocampus: the Involvement of Learning Memory Injury, Dysfunction of Glutamate Metabolism and NMDA Receptors.

PubMed

Huo, Tao-guang; Li, Wei-kai; Zhang, Ying-hua; Yuan, Jie; Gao, Lan-yue; Yuan, Yuan; Yang, Hui-lei; Jiang, Hong; Sun, Gui-fan

2015-01-01

Realgar is a type of mineral drug containing arsenic. The nervous system toxicity of realgar has received extensive attention. However, the underlying mechanisms of realgar-induced neurotoxicity have not been clearly elucidated. To explore the mechanisms that contribute to realgar-induced neurotoxicity, weanling rats were exposed to realgar (0, 0.3, 0.9, 2.7 g/kg) for 6 weeks, and cognitive ability was tested using the Morris water maze (MWM) test and object recognition task (ORT). The levels of arsenic in the blood and hippocampus were monitored. The ultrastructures of hippocampal neurons were observed. The levels of glutamate (Glu) and glutamine (Gln) in the hippocampus and hippocampal CA1 region; the activities of glutamine synthetase (GS) and phosphate-activated glutaminase (PAG); the mRNA and protein expression of glutamate transporter 1 (GLT-1), glutamate/aspartate transporter (GLAST), and N-methyl-D-aspartate (NMDA) receptors; and the level of intracellular Ca(2+) were also investigated. The results indicate that the rats developed deficiencies in cognitive ability after a 6-week exposure to realgar. The arsenic contained in realgar and the arsenic metabolites passed through the blood-brain barrier (BBB) and accumulated in the hippocampus, which resulted in the excessive accumulation of Glu in the extracellular space. The excessive accumulation of Glu in the extracellular space induced excitotoxicity, which was shown by enhanced GS and PAG activities, inhibition of GLT-1 mRNA and protein expression, alterations in NMDA receptor mRNA and protein expression, disturbance of intracellular Ca(2+) homeostasis, and ultrastructural changes in hippocampal neurons. In conclusion, the findings from our study indicate that exposure to realgar induces excitotoxicity and that the mechanism by which this occurs may be associated with disturbances in Glu metabolism and transportation and alterations in NMDA receptor expression.

High-Energy Emission From Millisecond Pulsars

NASA Technical Reports Server (NTRS)

Harding, Alice K.; Usov, Vladimir V.; Muslimov, Alex G.

2004-01-01

The X-ray and gamma-ray spectrum of rotation-powered millisecond pulsars is investigated in a model for acceleration and pair cascades on open field lines above the polar caps. Although these pulsars have low surface magnetic fields, their short periods allow them to have large magnetospheric potential drops, but the majority do not produce sufficient pairs to completely screen the accelerating electric field. In these sources, the primary and secondary electrons continue to accelerate to high altitude and their Lorentz factors are limited by curvature and synchrotron radiation reaction. The accelerating particles maintain high Lorentz factors and undergo cyclotron resonant absorption of radio emission, that produces and maintains a large pitch angle, resulting in a strong synchrotron component. The resulting spectra consist of several distinct components: curvature radiation from primary electrons dominating from 1 - 100 GeV, synchrotron radiation from primary and secondary electrons dominating up to about 100 MeV, and much weaker inverse-Compton radiation from primary electrons a t 0.1 - 1 TeV. We find that the relative size of these components depends on pulsar period, period derivative, and neutron star mass and radius with the level of the synchrotron component also depending sensitively on the radio emission properties. This model is successful in describing the observed X-ray and gamma-ray spectrum of PSR J0218+4232 as synchrotron radiation, peaking around 100 MeV and extending up to a turnover around several GeV. The predicted curvature radiation components from a number of millisecond pulsars, as well as the collective emission from the millisecond pulsars in globular clusters, should be detectable with AGILE and GLAST. We also discuss a hidden population of X-ray-quiet and radio-quiet millisecond pulsars which have evolved below the pair death line, some of which may be detectable by telescopes sensitive above 1 GeV. Subject headings: pulsars: general - radiation mechanisms: nonthermal - stars: neutron - gamma rays: theory

Social defeat promotes a reactive endothelium in a brain region-dependent manner with increased expression of key adhesion molecules, selectins and chemokines associated with the recruitment of myeloid cells to the brain.

PubMed

Sawicki, C M; McKim, D B; Wohleb, E S; Jarrett, B L; Reader, B F; Norden, D M; Godbout, J P; Sheridan, J F

2015-08-27

Repeated social defeat (RSD) in mice causes myeloid cell trafficking to the brain that contributes to the development of prolonged anxiety-like behavior. Myeloid cell recruitment following RSD occurs in regions where neuronal and microglia activation is observed. Thus, we hypothesized that crosstalk between neurons, microglia, and endothelial cells contributes to brain myeloid cell trafficking via chemokine signaling and vascular adhesion molecules. Here we show that social defeat caused an exposure- and brain region-dependent increase in several key adhesion molecules and chemokines involved in the recruitment of myeloid cells. For example, RSD induced distinct patterns of adhesion molecule expression that may explain brain region-dependent myeloid cell trafficking. VCAM-1 and ICAM-1 mRNA expression were increased in an exposure-dependent manner. Furthermore, RSD-induced VCAM-1 and ICAM-1 protein expression were localized to the vasculature of brain regions implicated in fear and anxiety responses, which spatially corresponded to previously reported patterns of myeloid cell trafficking. Next, mRNA expression of additional adhesion molecules (E- and P-selectin, PECAM-1) and chemokines (CXCL1, CXCL2, CXCL12, CCL2) were determined in the brain. Social defeat induced an exposure-dependent increase in mRNA levels of E-selectin, CXCL1, and CXCL2 that increased with additional days of social defeat. While CXCL12 was unaffected by RSD, CCL2 expression was increased by six days of social defeat. Last, comparison between enriched CD11b(+) cells (microglia/macrophages) and enriched GLAST-1(+)/CD11b(-) cells (astrocytes) revealed RSD increased mRNA expression of IL-1β, CCL2, and CXCL2 in microglia/macrophages but not in astrocytes. Collectively, these data indicate that key mediators of leukocyte recruitment were increased in the brain vasculature following RSD in an exposure- and brain region-dependent manner. Copyright © 2014 IBRO. Published by Elsevier Ltd. All rights reserved.

Social defeat promotes a reactive endothelium in a brain region-dependent manner with increased expression of key adhesion molecules, selectins and chemokines associated with the recruitment of myeloid cells to the brain

PubMed Central

Sawicki, Caroline M.; McKim, Daniel B.; Wohleb, Eric S.; Jarrett, Brant L.; Reader, Brenda F.; Norden, Diana M.; Godbout, Jonathan P.; Sheridan, John F.

2014-01-01

Repeated social defeat (RSD) in mice causes myeloid cell trafficking to the brain that contributes to the development of prolonged anxiety-like behavior. Myeloid cell recruitment following RSD occurs in regions where neuronal and microglia activation is observed. Thus, we hypothesized that crosstalk between neurons, microglia, and endothelial cells contributes to brain-myeloid cell trafficking via chemokine signaling and vascular adhesion molecules. Here we show that social defeat caused an exposure- and brain region-dependent increase in several key adhesion molecules and chemokines involved in the recruitment of myeloid cells. For example, RSD induced distinct patterns of adhesion molecule expression that may explain brain region-dependent myeloid cell trafficking. VCAM-1 and ICAM-1 mRNA expression were increased in an exposure-dependent manner. Furthermore, RSD-induced VCAM-1 and ICAM-1 protein expression were localized to the vasculature of brain regions implicated in fear and anxiety responses, which spatially corresponded to previously reported patterns of myeloid cell trafficking. Next, mRNA expression of additional adhesion molecules (E- and P-selectin, PECAM-1) and chemokines (CXCL1, CXCL2, CXCL12, CCL2) were determined in the brain. Social defeat induced an exposure-dependent increase in mRNA levels of E-selectin, CXCL1, and CXCL2 that increased with additional days of social defeat. While CXCL12 was unaffected by RSD, CCL2 expression was increased by six days of social defeat. Last, comparison between enriched CD11b+ cells (microglia/macrophages) and enriched GLAST-1+/CD11b− cells (astrocytes) revealed RSD increased mRNA expression of IL-1β, CCL2, and CXCL2 in microglia/macrophages but not in astrocytes. Collectively, these data indicate that key mediators of leukocyte recruitment were increased in the brain vasculature following RSD in an exposure- and brain-region dependent manner. PMID:25445193

300 GeV Observations of Unidentified EGRET Sources. A Search for TeV Counterparts to BATSE Gamma-ray Bursts

NASA Technical Reports Server (NTRS)

Weekes, Trevor C.

1998-01-01

There are few things more intriguing in high energy astrophysics than the study of the highest energy particles in the universe. Where and how these particles achieve their extreme energies is of interest not only to the astrophysicist but also to the particle physicist. At GeV and TeV energies the problem is manageable since the physics is known and the acceleration processes feasible. But the energy spectrum extends to 10(exp 20)Ev and there the problem of their origin is both more difficult and interesting; in fact at these high energies we do not even know what the particles are. The study of the origin and distribution of relativistic particles in the universe has been a challenge for more than 80 years but it is only in recent years that the technology has become available to really address the question. Although something can be learned from studies of composition and energy spectrum, the origins (and thence the acceleration mechanisms) can only come from the direct study of the neutral particle component (in this respect the highest energy particles are effectively neutral since they are virtually undeflected). The feasible channels of investigation are therefore the study of the arrival directions of: (1) TeV photons (covered by the following U.S. experiments: STACEE, Whipple/VERITAS, MILAGRO and, to some extent, by EGRET/GLAST); (2) neutrinos of TeV energy and above (AMANDA/KM3); (3) the highest energy cosmic rays (HiRes, Auger). While these studies represent a form of astronomy they are the astronomy of the extraordinary universe, the universe populated by the most dynamic and physically exciting objects, the universe of the high energy astrophysicist whose cosmic laboratories represent conditions beyond anything that can be duplicated in a terrestrial laboratory. This extraordinary astronomy may say little about the normal evolution of stars and galaxies but it opens windows into cosmic particle acceleration where new and strange physical processes take place.

Realistic Simulations of Coronagraphic Observations with Future Space Telescopes

NASA Astrophysics Data System (ADS)

Rizzo, M. J.; Roberge, A.; Lincowski, A. P.; Zimmerman, N. T.; Juanola-Parramon, R.; Pueyo, L.; Hu, M.; Harness, A.

2017-11-01

We present a framework to simulate realistic observations of future space-based coronagraphic instruments. This gathers state-of-the-art scientific and instrumental expertise allowing robust characterization of future instrument concepts.

Handbook for Designing MMOD Protection

NASA Technical Reports Server (NTRS)

Arnold, Jim; Christiansen, Eric L.; Davis, Alan; Hyde, James; Lear, Dana; Liou, J.C.; Lyons, Frankel; Prior, Thomas; Studor, George; Ratliff, Martin;

The First Fermi Large Area Telescope Catalog of Gamma-ray Pulsars

DOE PAGES

Abdo, A. A.; Ackermann, M.; Ajello, M.; ...

2010-03-25

The dramatic increase in the number of known gamma-ray pulsars since the launch of the Fermi Gamma-ray Space Telescope (formerly GLAST) offers the first opportunity to study a sizable population of these high-energy objects. This catalog summarizes 46 high-confidence pulsed detections using the first six months of data taken by the Large Area Telescope (LAT), Fermi's main instrument. Sixteen previously unknown pulsars were discovered by searching for pulsed signals at the positions of bright gamma-ray sources seen with the LAT, or at the positions of objects suspected to be neutron stars based on observations at other wavelengths. The dimmest observed flux among these gamma-ray-selected pulsars is 6.0 × 10 –8 ph cm –2 s –1 (for E>100 MeV). Pulsed gamma-ray emission was discovered from 24 known pulsars by using ephemerides (timing solutions) derived from monitoring radio pulsars. Eight of these new gamma-ray pulsars are millisecond pulsars. The dimmest observed flux among the radio-selected pulsars is 1.4 × 10 –8 ph cm –2 s –1 (for E>100 MeV). The remaining six gamma-ray pulsars were known since the Compton Gamma Ray Observatory mission, or before. The limiting flux for pulse detection is non-uniform over the sky owing to different background levels, especially near the Galactic plane. The pulsed energy spectra can be described by a power law with an exponential cutoff, with cutoff energies in the range ~1-5 GeV. The rotational energy-loss rate (more » $$\\dot{E}$$) of these neutron stars spans five decades, from ~3 × 10 33 erg s –1 to 5 × 10 38 erg s –1, and the apparent efficiencies for conversion to gamma-ray emission range from ~0.1% to ~ unity, although distance uncertainties complicate efficiency estimates. The pulse shapes show substantial diversity, but roughly 75% of the gamma-ray pulse profiles have two peaks, separated by ≳0.2 of rotational phase. For most of the pulsars, gamma-ray emission appears to come mainly from the outer magnetosphere, while polar-cap emission remains plausible for a remaining few. Spatial associations imply that many of these pulsars power pulsar wind nebulae. In conclusion, these discoveries suggest that gamma-ray-selected young pulsars are born at a rate comparable to that of their radio-selected cousins and that the birthrate of all young gamma-ray-detected pulsars is a substantial fraction of the expected Galactic supernova rate.« less

The hubris hypothesis: The downside of comparative optimism displays.

PubMed

Hoorens, Vera; Van Damme, Carolien; Helweg-Larsen, Marie; Sedikides, Constantine

2017-04-01

According to the hubris hypothesis, observers respond more unfavorably to individuals who express their positive self-views comparatively than to those who express their positive self-views non-comparatively, because observers infer that the former hold a more disparaging view of others and particularly of observers. Two experiments extended the hubris hypothesis in the domain of optimism. Observers attributed less warmth (but not less competence) to, and showed less interest in affiliating with, an individual displaying comparative optimism (the belief that one's future will be better than others' future) than with an individual displaying absolute optimism (the belief that one's future will be good). Observers responded differently to individuals displaying comparative versus absolute optimism, because they inferred that the former held a gloomier view of the observers' future. Consistent with previous research, observers still attributed more positive traits to a comparative or absolute optimist than to a comparative or absolute pessimist. Copyright © 2016. Published by Elsevier Inc.

Glycogen serves as an energy source that maintains astrocyte cell proliferation in the neonatal telencephalon.

PubMed

Gotoh, Hitoshi; Nomura, Tadashi; Ono, Katsuhiko

2017-06-01

Large amounts of energy are required when cells undergo cell proliferation and differentiation for mammalian neuronal development. Early neonatal mice face transient starvation and use stored energy for survival or to support development. Glycogen is a branched polysaccharide that is formed by glucose, and serves as an astrocytic energy store for rapid energy requirements. Although it is present in radial glial cells and astrocytes, the role of glycogen during development remains unclear. In the present study, we demonstrated that glycogen accumulated in glutamate aspartate transporter (GLAST)+ astrocytes in the subventricular zone and rostral migratory stream. Glycogen levels markedly decreased after birth due to the increase of glycogen phosphorylase, an essential enzyme for glycogen metabolism. In primary cultures and in vivo, the inhibition of glycogen phosphorylase decreased the proliferation of astrocytic cells. The number of cells in the G1 phase increased in combination with the up-regulation of cyclin-dependent kinase inhibitors or down-regulation of the phosphorylation of retinoblastoma protein (pRB), a determinant for cell cycle progression. These results suggest that glycogen accumulates in astrocytes located in specific areas during the prenatal stage and is used as an energy source to maintain normal development in the early postnatal stage.

EGRET Diffuse Gamma Ray Maps Between 30 MeV and 10 GeV

NASA Technical Reports Server (NTRS)

Cillis, A, N.; Hartman, R. C.

2004-01-01

This paper presents all-sky maps of diffuse gamma radiation in various energy ranges between 30 MeV and 10 GeV, based on data collected by the EGRET instrument on the Compton Gamma Ray Observatory. Although the maps can be used for a variety of applications. the immediate goal is the generation of diffuse gamma-ray maps which can be used as a diffuse background/foreground for point source analysis of the data to be obtained from new high-energy gamma-ray missions like GLAST and AGILE. To generate the diffuse gamma maps from the raw EGRET maps, the point sources in the Third EGRET Catalog were subtracted out using the appropriate point spread function for each energy range. After that, smoothing was performed to minimize the effects of photon statistical noise. A smoothing length of 1 deg vas used for the Galactic plane maps. For the all-sky maps, a procedure was used which resulted in a smoothing length roughly equivalent to 4 deg. The result of this work is 16 maps of different energy intervals for absolute value of b < or equal to 20 deg, and 32 all-sky maps, 16 in equatorial coordinates (J2000) and 16 in Galactic coordinates.

EGRET Diffuse Gamma Ray Maps Between 30 MeV and 10 GeV

NASA Technical Reports Server (NTRS)

Cillis, A. N.; Hartman, R. C.

2004-01-01

This paper presents all-sky maps of diffuse gamma radiation in various energy ranges between 30 MeV and 10 GeV, based on data collected by the EGRET instrument on the Compton Gamma Ray Observatory. Although the maps can be used for a variety of applications, the immediate goal is the generation of diffuse gamma-ray maps which can be used as a diffuse background/foreground for point source analysis of the data to be obtained from new high-energy gamma-ray missions like GLAST and AGILE. To generate the diffuse gamma maps from the raw EGRET maps, the point sources in the Third EGRET Catalog were subtracted out using the appropriate point spread function for each energy range. After that, smoothing was performed to minimize the effects of photon statistical noise. A smoothing length of 1deg was used for the Galactic plane maps. For the all-sky maps, a procedure was used which resulted in a smoothing length roughly equivalent to 4deg. The result of this work is 16 maps of different energy intervals for [b]less than or equal to 20deg, and 32 all-sky maps, 16 in equatorial coordinates (J2000) and 16 in Galactic coordinates.

Pulsar timing for the Fermi gamma-ray space telescope

DOE PAGES

Smith, D. A.; Guillemot, L.; Camilo, F.; ...

2008-10-27

Here, we describe a comprehensive pulsar monitoring campaign for the Large Area Telescope (LAT) on the Fermi Gamma-ray Space Telescope (formerly GLAST). The detection and study of pulsars in gamma rays give insights into the populations of neutron stars and supernova rates in the Galaxy, into particle acceleration mechanisms in neutron star magnetospheres, and into the “engines” driving pulsar wind nebulae. LAT's unprecedented sensitivity between 20 MeV and 300 GeV together with its 2.4 sr field-of-view makes detection of many gamma-ray pulsars likely, justifying the monitoring of over two hundred pulsars with large spin-down powers. To search for gamma-ray pulsationsmore » from most of these pulsars requires a set of phase-connected timing solutions spanning a year or more to properly align the sparse photon arrival times. We describe the choice of pulsars and the instruments involved in the campaign. Attention is paid to verifications of the LAT pulsar software, using for example giant radio pulses from the Crab and from PSR B1937+21 recorded at Nançay, and using X-ray data on PSR J0218+4232 from XMM-Newton. We demonstrate accuracy of the pulsar phase calculations at the microsecond level.« less

Understanding the past to interpret the future: Comparison of simulated groundwater recharge in the upper Colorado River basin (USA) using observed and general-circulation-model historical climate data

USGS Publications Warehouse

Tillman, Fred D.; Gangopadhyay, Subhrendu; Pruitt, Tom

2017-01-01

In evaluating potential impacts of climate change on water resources, water managers seek to understand how future conditions may differ from the recent past. Studies of climate impacts on groundwater recharge often compare simulated recharge from future and historical time periods on an average monthly or overall average annual basis, or compare average recharge from future decades to that from a single recent decade. Baseline historical recharge estimates, which are compared with future conditions, are often from simulations using observed historical climate data. Comparison of average monthly results, average annual results, or even averaging over selected historical decades, may mask the true variability in historical results and lead to misinterpretation of future conditions. Comparison of future recharge results simulated using general circulation model (GCM) climate data to recharge results simulated using actual historical climate data may also result in an incomplete understanding of the likelihood of future changes. In this study, groundwater recharge is estimated in the upper Colorado River basin, USA, using a distributed-parameter soil-water balance groundwater recharge model for the period 1951–2010. Recharge simulations are performed using precipitation, maximum temperature, and minimum temperature data from observed climate data and from 97 CMIP5 (Coupled Model Intercomparison Project, phase 5) projections. Results indicate that average monthly and average annual simulated recharge are similar using observed and GCM climate data. However, 10-year moving-average recharge results show substantial differences between observed and simulated climate data, particularly during period 1970–2000, with much greater variability seen for results using observed climate data.

Optimal observation network design for conceptual model discrimination and uncertainty reduction

NASA Astrophysics Data System (ADS)

Pham, Hai V.; Tsai, Frank T.-C.

2016-02-01

This study expands the Box-Hill discrimination function to design an optimal observation network to discriminate conceptual models and, in turn, identify a most favored model. The Box-Hill discrimination function measures the expected decrease in Shannon entropy (for model identification) before and after the optimal design for one additional observation. This study modifies the discrimination function to account for multiple future observations that are assumed spatiotemporally independent and Gaussian-distributed. Bayesian model averaging (BMA) is used to incorporate existing observation data and quantify future observation uncertainty arising from conceptual and parametric uncertainties in the discrimination function. In addition, the BMA method is adopted to predict future observation data in a statistical sense. The design goal is to find optimal locations and least data via maximizing the Box-Hill discrimination function value subject to a posterior model probability threshold. The optimal observation network design is illustrated using a groundwater study in Baton Rouge, Louisiana, to collect additional groundwater heads from USGS wells. The sources of uncertainty creating multiple groundwater models are geological architecture, boundary condition, and fault permeability architecture. Impacts of considering homoscedastic and heteroscedastic future observation data and the sources of uncertainties on potential observation areas are analyzed. Results show that heteroscedasticity should be considered in the design procedure to account for various sources of future observation uncertainty. After the optimal design is obtained and the corresponding data are collected for model updating, total variances of head predictions can be significantly reduced by identifying a model with a superior posterior model probability.

Efficient optical cloud removal technique for earth observation based on MOEMs device

NASA Astrophysics Data System (ADS)

Zamkotsian, Frédéric; Lanzoni, Patrick; Liotard, Arnaud; Viard, Thierry; Noell, Wilfried

2017-11-01

In Earth Observation instruments, observation of scenes including bright sources leads to an important degradation of the recorded signal. We propose a new concept to remove dynamically the bright sources and then obtain a field of view with an optically enhanced Signal-to-Noise Ratio (SNR). Micro-Opto-Electro-Mechanical Systems (MOEMS) could be key components in future generation of space instruments. MOEMS-based programmable slit masks will permit the straylight control in future Earth Observation instruments. Experimental demonstration of this concept has been conducted on a dedicated bench. This successful first demonstration shows the high potential of this new concept in future spectro-imager for Earth Observation.

GLAST/EAAT1-induced glutamine release via SNAT3 in Bergmann glial cells: evidence of a functional and physical coupling.

PubMed

Martínez-Lozada, Zila; Guillem, Alain M; Flores-Méndez, Marco; Hernández-Kelly, Luisa C; Vela, Carmelita; Meza, Enrique; Zepeda, Rossana C; Caba, Mario; Rodríguez, Angelina; Ortega, Arturo

2013-05-01

Glutamate, the major excitatory transmitter in the vertebrate brain, is removed from the synaptic cleft by a family of sodium-dependent glutamate transporters profusely expressed in glial cells. Once internalized, it is metabolized by glutamine synthetase to glutamine and released to the synaptic space through sodium-dependent neutral amino acid carriers of the N System (SNAT3/slc38a3/SN1, SNAT5/slc38a5/SN2). Glutamine is then taken up by neurons completing the so-called glutamate/glutamine shuttle. Despite of the fact that this coupling was described decades ago, it is only recently that the biochemical framework of this shuttle has begun to be elucidated. Using the established model of cultured cerebellar Bergmann glia cells, we sought to characterize the functional and physical coupling of glutamate uptake and glutamine release. A time-dependent Na⁺-dependent glutamate/aspartate transporter/EAAT1-induced System N-mediated glutamine release could be demonstrated. Furthermore, D-aspartate, a specific glutamate transporter ligand, was capable of enhancing the co-immunoprecipitation of Na⁺-dependent glutamate/aspartate transporter and Na⁺-dependent neutral amino acid transporter 3, whereas glutamine tended to reduce this association. Our results suggest that glial cells surrounding glutamatergic synapses may act as sensors of neuron-derived glutamate through their contribution to the neurotransmitter turnover. © 2013 International Society for Neurochemistry.

Science Goals for an All-sky Viewing Observatory in X-rays

NASA Astrophysics Data System (ADS)

Remillard, R. A.; Levine, A. M.; Morgan, E. H.; Bradt, H. V.

2003-03-01

We describe a concept for a NASA SMEX Mission that will provide a comprehensive investigation of cosmic explosions. These range from the short flashes at cosmological distances in Gamma-ray bursts, to the moments of relativistic mass ejections in Galactic microquasars, to the panorama of outbursts used to identify the stellar-scale black holes in our Galaxy. With an equatorial launch, an array of 31 cameras can cover 97% of the sky with an average exposure efficiency of 65%. Coded mask cameras with Xe detectors (1.5-12 keV) are chosen for their ability to distinguish thermal and non-thermal processes, while providing high throughput and msec time resolution to capture the detailed evolution of bright events. This mission, with 1' position accuracy, would provide a long-term solution to the critical needs for monitoring services for Chandra and GLAST, with possible overlap into the time frame for Constellation-X. The sky coverage would create additional science opportunities beyond the X-ray missions: "eyes" for LIGO and partnerships for time-variability with LOFAR and dedicated programs at optical observatories. Compared to the RXTE ASM, AVOX offers improvements by a factor of 40 in instantaneous sky coverage and a factor of 10 in sensitivity to faint X-ray sources (i.e. to 0.8 mCrab at 3 sigma in 1 day).

Dissecting the long-term emission behaviour of the BL Lac object Mrk 421

NASA Astrophysics Data System (ADS)

Carnerero, M. I.; Raiteri, C. M.; Villata, M.; Acosta-Pulido, J. A.; Larionov, V. M.; Smith, P. S.; D'Ammando, F.; Agudo, I.; Arévalo, M. J.; Bachev, R.; Barnes, J.; Boeva, S.; Bozhilov, V.; Carosati, D.; Casadio, C.; Chen, W. P.; Damljanovic, G.; Eswaraiah, E.; Forné, E.; Gantchev, G.; Gómez, J. L.; González-Morales, P. A.; Griñón-Marín, A. B.; Grishina, T. S.; Holden, M.; Ibryamov, S.; Joner, M. D.; Jordan, B.; Jorstad, S. G.; Joshi, M.; Kopatskaya, E. N.; Koptelova, E.; Kurtanidze, O. M.; Kurtanidze, S. O.; Larionova, E. G.; Larionova, L. V.; Latev, G.; Lázaro, C.; Ligustri, R.; Lin, H. C.; Marscher, A. P.; Martínez-Lombilla, C.; McBreen, B.; Mihov, B.; Molina, S. N.; Moody, J. W.; Morozova, D. A.; Nikolashvili, M. G.; Nilsson, K.; Ovcharov, E.; Pace, C.; Panwar, N.; Pastor Yabar, A.; Pearson, R. L.; Pinna, F.; Protasio, C.; Rizzi, N.; Redondo-Lorenzo, F. J.; Rodríguez-Coira, G.; Ros, J. A.; Sadun, A. C.; Savchenko, S. S.; Semkov, E.; Slavcheva-Mihova, L.; Smith, N.; Strigachev, A.; Troitskaya, Yu. V.; Troitsky, I. S.; Vasilyev, A. A.; Vince, O.

2017-12-01

We report on long-term multiwavelength monitoring of blazar Mrk 421 by the GLAST-AGILE Support Program of the Whole Earth Blazar Telescope (GASP-WEBT) collaboration and Steward Observatory, and by the Swift and Fermi satellites. We study the source behaviour in the period 2007-2015, characterized by several extreme flares. The ratio between the optical, X-ray and γ-ray fluxes is very variable. The γ-ray flux variations show a fair correlation with the optical ones starting from 2012. We analyse spectropolarimetric data and find wavelength-dependence of the polarization degree (P), which is compatible with the presence of the host galaxy, and no wavelength dependence of the electric vector polarization angle (EVPA). Optical polarimetry shows a lack of simple correlation between P and flux and wide rotations of the EVPA. We build broad-band spectral energy distributions with simultaneous near-infrared and optical data from the GASP-WEBT and ultraviolet and X-ray data from the Swift satellite. They show strong variability in both flux and X-ray spectral shape and suggest a shift of the synchrotron peak up to a factor of ∼50 in frequency. The interpretation of the flux and spectral variability is compatible with jet models including at least two emitting regions that can change their orientation with respect to the line of sight.

Alteration in mitochondrial function and glutamate metabolism affected by 2-chloroethanol in primary cultured astrocytes.

PubMed

Sun, Qi; Liao, Yingjun; Wang, Tong; Wang, Gaoyang; Zhao, Fenghong; Jin, Yaping

2016-12-01

The aim of this study was to explore the mechanisms that contribute to 1,2-dichloroethane (1,2-DCE) induced brain edema by focusing on alteration of mitochondrial function and glutamate metabolism in primary cultured astrocytes induced by 2-chloroethanol (2-CE), a metabolite of 1,2-DCE in vivo. The cells were exposed to different levels of 2-CE in the media for 24h. Mitochondrial function was evaluated by its membrane potential and intracellular contents of ATP, lactic acid and reactive oxygen species (ROS). Glutamate metabolism was indicated by expression of glutamine synthase (GS), glutamate-aspartate transporter (GLAST) and glutamate transporter-1 (GLT-1) at both protein and gene levels. Compared to the control group, exposure to 2-CE could cause a dose dependent damage in astrocytes, indicated by decreased cell viability and morphological changes, and supported by decreased levels of nonprotein sulfhydryl (NPSH) and inhibited activities of Na + /K + -ATPase and Ca 2+ -ATPase in the cells. The present study also revealed both mitochondrial function and glutamate metabolism in astrocytes were significantly disturbed by 2-CE. Of which, mitochondrial function was much vulnerable to the effects of 2-CE. In conclusion, our findings suggested that mitochondrial dysfunction and glutamate metabolism disorder could contribute to 2-CE-induced cytotoxicity in astrocytes, which might be related to 1,2-DCE-induced brain edema. Copyright © 2016 Elsevier Ltd. All rights reserved.

The 'glial' glutamate transporter, EAAT2 (Glt-1) accounts for high affinity glutamate uptake into adult rodent nerve endings.

PubMed

Suchak, Sachin K; Baloyianni, Nicoletta V; Perkinton, Michael S; Williams, Robert J; Meldrum, Brian S; Rattray, Marcus

2003-02-01

The excitatory amino acid transporters (EAAT) removes neurotransmitters glutamate and aspartate from the synaptic cleft. Most CNS glutamate uptake is mediated by EAAT2 into glia, though nerve terminals show evidence for uptake, through an unknown transporter. Reverse-transcriptase PCR identified the expression of EAAT1, EAAT2, EAAT3 and EAAT4 mRNAs in primary cultures of mouse cortical or striatal neurones. We have used synaptosomes and glial plasmalemmal vesicles (GPV) from adult mouse and rat CNS to identify the nerve terminal transporter. Western blotting showed detectable levels of the transporters EAAT1 (GLAST) and EAAT2 (Glt-1) in both synaptosomes and GPVs. Uptake of [3H]D-aspartate or [3H]L-glutamate into these preparations revealed sodium-dependent uptake in GPV and synaptosomes which was inhibited by a range of EAAT blockers: dihydrokainate, serine-o-sulfate, l-trans-2,4-pyrrolidine dicarboxylate (PDC) (+/-)-threo-3-methylglutamate and (2S,4R )-4-methylglutamate. The IC50 values found for these compounds suggested functional expression of the 'glial, transporter, EAAT2 in nerve terminals. Additionally blockade of the majority EAAT2 uptake sites with 100 micro m dihydrokainate, failed to unmask any functional non-EAAT2 uptake sites. The data presented in this study indicate that EAAT2 is the predominant nerve terminal glutamate transporter in the adult rodent CNS.

Inclusion of Cocoa as a Dietary Supplement Represses Expression of Inflammatory Proteins in Spinal Trigeminal Nucleus in Response to Chronic Trigeminal Nerve Stimulation

PubMed Central

Cady, Ryan J.; Denson, Jennifer E.; Durham, Paul L.

2013-01-01

Scope Central sensitization is implicated in the pathology of temporomandibular joint disorder (TMD) and other types of orofacial pain. We investigated the effects of dietary cocoa on expression of proteins involved in the development of central sensitization in the spinal trigeminal nucleus (STN) in response to inflammatory stimulation of trigeminal nerves. Methods and results Male Sprague Dawley rats were fed either a control diet or an isocaloric diet consisting of 10% cocoa powder 14 days prior to bilateral injection of complete Freund’s adjuvant (CFA) into the temporomandibular joint to promote prolonged activation of trigeminal ganglion neurons and glia. While dietary cocoa stimulated basal expression of GLAST and MKP-1 when compared to animals on a normal diet, cocoa suppressed basal calcitonin gene-related peptide levels in the STN. CFA-stimulated levels of protein kinase A, P2X3, P-p38, GFAP, and OX-42, whose elevated levels in the STN are implicated in central sensitization, were repressed to near control levels in animals on a cocoa enriched diet. Similarly, dietary cocoa repressed CFA-stimulated inflammatory cytokine expression. Conclusion Based on our findings, we speculate that cocoa enriched diets could be beneficial as a natural therapeutic option for TMD and other chronic orofacial pain conditions. PMID:23576361

SMARTScience Tools: Interacting With Blazar Data In The Web Browser

NASA Astrophysics Data System (ADS)

Hasan, Imran; Isler, Jedidah; Urry, C. Megan; MacPherson, Emily; Buxton, Michelle; Bailyn, Charles D.; Coppi, Paolo S.

2014-08-01

The Yale-SMARTS blazar group has accumulated 6 years of optical-IR photometry of more than 70 blazars, mostly bright enough in gamma-rays to be detected with Fermi. Observations were done with the ANDICAM instrument on the SMARTS 1.3 m telescope at the Cerro Tololo Inter-American Observatory. As a result of this long-term, multiwavelength monitoring, we have produced a calibrated, publicly available data set (see www.astro.yale.edu/smarts/glast/home.php), which we have used to find that (i) optical-IR and gamma-ray light curves are well correlated, supporting inverse-Compton models for gamma-ray production (Bonning et al. 2009, 2012), (ii) at their brightest, blazar jets can contribute significantly to the photoionization of the broad-emission-line region, indicating that gamma-rays are produced within 0.1 pc of the black hole in at least some cases (Isler et al. 2014), and (iii) optical-IR and gamma-ray flares are symmetric, implying the time scales are dominated by light-travel-time effects rather than acceleration or cooling (Chatterjee et al. 2012). The volume of data and diversity of projects for which it is used calls out for an efficient means of visualization. To this end, we have developed a suite of visualization tools called SMARTScience Tools, which allow users to interact dynamically with our dataset. The SMARTScience Tools is publicly available via our webpage and can be used to customize multiwavelength light curves and color magnitude diagrams quickly and intuitively. Users can choose specific bands to construct plots, and the plots include features such as band-by-band panning, dynamic zooming, and direct mouse interaction with individual data points. Human and machine readable tables of the plotted data can be directly printed for the user's convenience and for further independent study. The SMARTScience Tools significantly improves the public’s ability to interact with the Yale-SMARTS 6-year data base of blazar photometry, and should make multiwavelength studies of blazars even more accessible, efficient, and community driven.

Downregulated Glia Interplay and Increased miRNA-155 as Promising Markers to Track ALS at an Early Stage.

PubMed

Cunha, Carolina; Santos, Catarina; Gomes, Cátia; Fernandes, Adelaide; Correia, Alexandra Marçal; Sebastião, Ana Maria; Vaz, Ana Rita; Brites, Dora

2018-05-01

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease of unknown cause. Absence of specific targets and biomarkers compromise the development of new therapeutic strategies and of innovative tools to stratify patients and assess their responses to treatment. Here, we investigate changes in neuroprotective-neuroinflammatory actions in the spinal cord of SOD1 G93A mice, at presymptomatic and symptomatic stages to identify stage-specific biomarkers and potential targets. Results showed that in the presymptomatic stage, there are alterations in both astrocytes and microglia, which comprise decreased expression of GFAP and S100B and upregulation of GLT-1, as well as reduced expression of CD11b, M2-phenotype markers, and a set of inflammatory mediators. Reduced levels of Connexin-43, Pannexin-1, CCL21, and CX3CL1 further indicate the existence of a compromised intercellular communication. In contrast, in the symptomatic stage, increased markers of inflammation became evident, such as NF-κB/Nlrp3-inflammasome, Iba1, pro-inflammatory cytokines, and M1-polarizion markers, together with a decreased expression of M2-phenotypic markers. We also observed upregulation of the CX3CL1-CX3CR1 axis, Connexin-43, Pannexin-1, and of microRNAs (miR)-124, miR-125b, miR-146a and miR-21. Reduced motor neuron number and presence of reactive astrocytes with decreased GFAP, GLT-1, and GLAST further characterized this inflammatory stage. Interestingly, upregulation of miR-155 and downregulation of MFG-E8 appear as consistent biomarkers of both presymptomatic and symptomatic stages. We hypothesize that downregulated cellular interplay at the early stages may represent neuroprotective mechanisms against inflammation, SOD1 aggregation, and ALS onset. The present study identified a set of inflamma-miRNAs, NLRP3-inflammasome, HMGB1, CX3CL1-CX3CR1, Connexin-43, and Pannexin-1 as emerging candidates and promising pharmacological targets that may represent potential neuroprotective strategies in ALS therapy.

Spontaneous innovation for future deception in a male chimpanzee.

PubMed

Osvath, Mathias; Karvonen, Elin

2012-01-01

The ability to invent means to deceive others, where the deception lies in the perceptually or contextually detached future, appears to require the coordination of sophisticated cognitive skills toward a single goal. Meanwhile innovation for a current situation has been observed in a wide range of species. Planning, on the one hand, and the social cognition required for deception on the other, have been linked to one another, both from a co-evolutionary and a neuroanatomical perspective. Innovation and deception have also been suggested to be connected in their nature of relying on novelty. We report on systematic observations suggesting innovation for future deception by a captive male chimpanzee (Pan troglodytes). As an extension of previously described behaviour--caching projectiles for later throwing at zoo visitors--the chimpanzee, again in advance, manufactured concealments from hay, as well as used naturally occurring concealments. All were placed near the visitors' observation area, allowing the chimpanzee to make throws before the crowd could back off. We observed what was likely the first instance of this innovation. Further observations showed that the creation of future-oriented concealments became the significantly preferred strategy. What is more, the chimpanzee appeared consistently to combine two deceptive strategies: hiding projectiles and inhibiting dominance display behaviour. The findings suggest that chimpanzees can represent the future behaviours of others while those others are not present, as well as take actions in the current situation towards such potential future behaviours. Importantly, the behaviour of the chimpanzee produced a future event, rather than merely prepared for an event that had been reliably re-occurring in the past. These findings might indicate that the chimpanzee recombined episodic memories in perceptual simulations.

The Utilization of Classifications in High-Energy Astrophysics Experiments

NASA Astrophysics Data System (ADS)

Atwood, Bill

2012-03-01

The history of high-energy gamma observations stretches back several decades. But it was with the launch of the Energetic Gamma Ray Experiment Telescope (EGRET) in 1991 onboard the Compton Gamma Ray Observatory (CGRO) [1], that the field entered a new era of discovery. At the high-energy end of the electromagnetic spectrum, incoming particles of light, photons, interact with matter mainly by producing electron-positron pairs and this process dominates above an energy of 10-30MeV depending on the material. To a high degree the directionality of the incoming gamma ray is reflected in the e+ and e-, and hence the detection of the trajectories of the e+e- pair can be used to infer the direction of the originating photon. Measuring these high-energy charged particles is the domain of high-energy particle physics and so it should be of little surprise that particle physicists played a significant role in the design and construction of EGRET, as well as the design and implementation of analysis methods for the resulting data. Prior to EGRET, only a handful of sources in the sky were known as high-energy gamma-ray emitters. During EGRET's 9-years mission the final catalog included over 270 sources including new types such as Gamma Ray Bursts (GRBs). This set the stage for the next-generation mission, the Gamma ray Large Area Space Telescope (GLAST) [2]. Very early in the EGRET mission, the realization that the high-energy gamma-ray sky was extremely interesting led to a competition to develop the next-generation instruments. The technology used in EGRET was frozen in the late 1970s and by 1992, enormous advances had been made in experimental particle physics. In particular the effort to develop solid state detectors, targeted for use at the Super Conducting Super Collider (SSC), had made the technology of silicon strip detectors (SSDs) commercially viable for use in large area arrays. Given the limitations imposed by the space environment (e.g., operate in a vacuum, scarce availability of electric power, etc.), this was the ideal technology for the next gamma-ray mission. Consistent with contemporary practice in particle physics, a nearly complete and detailed computer model of GLAST was made to study performance and optimize the design. The jargon in the field refers to such models generically as "the Monte Carlo" (MC) and it included a complete suite of radiation transport codes modeling most of the known interactions that particles undergo upon passage through matter. The MC is also used to provide a randomized source of incoming particles which can be made to mimic celestial sources of gamma rays as well as background cosmic rays. The cosmic rays referred to here are comprised of two main components: trapped radiation in the earth's magnetosphere and a flux of primary charged particles originating from outside. Both fluxes contain a variety of particle types including protons, heavier nuclei, electrons, and positrons. It cannot be emphasized too strongly the value that such a tool brings. Having the "Monte Carlo Truth" for each simulated event allows for the evaluation of what went right and what went wrong both at the detector level as well as at the data analysis level. The Monte Carlo simulations of GLAST are at the heart of its success today. The simulations allowed for the development of the reconstruction analysis (RA) of the flight data prior to the existence of the instrument. The RA transforms the collections of sensor readouts in an event into tracks, energies, and other higher analysis entities. In the case of GLAST, there were many iterations of the RA, first to prove the merits of the design and then, post awarding of the flight instrument contract, the creation of the code to be used in the initial phases of the mission. Since then, the now renamed Fermi-LAT mission is engaged in the 8th such iteration. Critical to the success of any experiment are the identification and quantification of the "signal." Mostly all experiments have backgrounds or artifacts which obscure a clear signal and in the area of high-energy gamma-ray astronomy the situation is extreme. By the very nature of the detection method for gamma rays, it leaves the apparatus vulnerable to interpret cosmic rays as "signal." In low earth orbit the incoming rate of cosmic rays can exceed the gamma-ray rate by over 10,000. To achieve residual background levels in the percent range requires an aggregate separation power of upwards to a million-to-one while at the same time preserving a high efficiency for capturing the signal. From the triggering, to onboard filtering and ultimately the analysis on the ground, the goal is the same: kill background - keep gamma rays. The LAT, the hardware trigger, is a combination of sensor responses coincident at the microsecond timescale, causing all the sensors to be readout forming an "event." The LAT trigger was constructed to be highly efficient for gamma rays and as inefficient as possible for cosmic rays. The rejection power achieved by the trigger is about 5:1 while retaining over 98% efficiency for gamma rays. This still leaves a data event stream hopelessly large to downlink to the ground. A bank of onboard computers does a preliminary event reconstruction to increase the rejection power. For the LAT, this resulted in another factor of ∼5 while maintaining a gamma-ray efficiency of over 96%. Hence, what is downlinked to ground is an orbit averaged rate of about 400 cps of which only a few cps are gamma rays. All this complexity as to actual event composition (e.g., which cosmic ray events make it to the ground), is modeled in the simulations and provides a realistic facsimile to real data and this serves as the input to the ground analysis. Part of the requirements for the mission was to demonstrate prior to launch that the science goals were achievable and this included background rejection at a specified level. During the several years of development working toward this goal it was realized that the science requirements as written were not achievable mainly due to a background which we termed as "irreducible." Positrons hitting the outer protective layers of the LAT (the thermal blanket and micrometeor shield) can annihilate with the atomic electrons producing gammas and cosmic ray protons interacting with the same material produce neutral pions which then promptly decay into two gamma rays. In some cases, the only particles entering the fiducial volume of the detector are gamma rays from these processes and they are indistinguishable from celestial gamma rays. The rejection was increased until the majority of the remainder was "irreducible" in origin along with a demonstration that this residual could be subtracted with appropriately small systematic errors. The LAT instrument and reconstruction of the gamma-ray data from it fall into the realm of particle physics. Our first attempts at background rejection followed standard practice in particle physics: identify good discrimination variables and make cuts. What is meant by "cuts" is to accept (or reject) events for which a given variable (or variables) falls within (or outside) a certain range of values. This method, however, soon revealed itself to be inadequate especially when considering the resulting efficiency for retaining gamma rays. We then turned to data mining techniques which had seen considerable success in the life sciences and financial industries. In the end the classification tree technology was found to be inadequate by itself. A hybrid approach was developed in which first cuts are made using some of the discrimination variables to whittle down the problem and then the simplified problem is solved using a classification tree. In the next section we will see why classification trees offer a substantial increase in efficiency over the "cut and keep" paradigm. Other machine learning methods were tried, such as neural nets, but they were found to be inferior for this problem. It should come as little surprise to find that other gamma-ray experiments also found the classification tree technology advantageous for similar reasons. In particular the ground based Imaging Air Cherenkov Telescope (IACT), MAGIC [3], successfully developed a background rejection for its data based on classification trees. There are several packages which provide classification tree (CT)-based technology [4]. Some of these are commercial while others are free. Please see the references for specifics. In the discussion which follows, the commercial product by TIBCO (SpotfireMiner) is used [5].

The impact of shifting vantage perspective when recalling and imagining positive events.

PubMed

Vella, Nicholas C; Moulds, Michelle L

2014-01-01

The vantage perspective from which memories are recalled influences their emotional impact. To date, however, the impact of vantage perspective on the emotions elicited by positive memories and images of positive future events has been minimally explored. We experimentally manipulated the vantage perspective from which a sample of undergraduate students (n =80) recalled positive memories and imagined positive future events. Participants who naturally recalled their positive memories from a field perspective reported decreased vividness and positive affect (i.e., happiness, optimism, hopefulness) when they were instructed to shift to an observer perspective. The same pattern of emotionality ratings was observed when participants' vantage perspective of imagined future events was manipulated. In contrast, shifting participants from observer to field perspective recall of positive memories did not result in changes in ratings of memory-related emotion, although we found an unexpected trend towards reduced vividness. For positive future events, shifting from an observer to a field perspective resulted in decreased vividness but did not lead to any changes in positive emotion. Our findings confirm that vantage perspective plays a key role in determining the emotional impact of positive memories, and demonstrate that this relationship is also evident for images of future positive events.

From Sensor to Observation Web with environmental enablers in the Future Internet.

PubMed

Havlik, Denis; Schade, Sven; Sabeur, Zoheir A; Mazzetti, Paolo; Watson, Kym; Berre, Arne J; Mon, Jose Lorenzo

2011-01-01

This paper outlines the grand challenges in global sustainability research and the objectives of the FP7 Future Internet PPP program within the Digital Agenda for Europe. Large user communities are generating significant amounts of valuable environmental observations at local and regional scales using the devices and services of the Future Internet. These communities' environmental observations represent a wealth of information which is currently hardly used or used only in isolation and therefore in need of integration with other information sources. Indeed, this very integration will lead to a paradigm shift from a mere Sensor Web to an Observation Web with semantically enriched content emanating from sensors, environmental simulations and citizens. The paper also describes the research challenges to realize the Observation Web and the associated environmental enablers for the Future Internet. Such an environmental enabler could for instance be an electronic sensing device, a web-service application, or even a social networking group affording or facilitating the capability of the Future Internet applications to consume, produce, and use environmental observations in cross-domain applications. The term "envirofied" Future Internet is coined to describe this overall target that forms a cornerstone of work in the Environmental Usage Area within the Future Internet PPP program. Relevant trends described in the paper are the usage of ubiquitous sensors (anywhere), the provision and generation of information by citizens, and the convergence of real and virtual realities to convey understanding of environmental observations. The paper addresses the technical challenges in the Environmental Usage Area and the need for designing multi-style service oriented architecture. Key topics are the mapping of requirements to capabilities, providing scalability and robustness with implementing context aware information retrieval. Another essential research topic is handling data fusion and model based computation, and the related propagation of information uncertainty. Approaches to security, standardization and harmonization, all essential for sustainable solutions, are summarized from the perspective of the Environmental Usage Area. The paper concludes with an overview of emerging, high impact applications in the environmental areas concerning land ecosystems (biodiversity), air quality (atmospheric conditions) and water ecosystems (marine asset management).

From Sensor to Observation Web with Environmental Enablers in the Future Internet

PubMed Central

Havlik, Denis; Schade, Sven; Sabeur, Zoheir A.; Mazzetti, Paolo; Watson, Kym; Berre, Arne J.; Mon, Jose Lorenzo

2011-01-01

This paper outlines the grand challenges in global sustainability research and the objectives of the FP7 Future Internet PPP program within the Digital Agenda for Europe. Large user communities are generating significant amounts of valuable environmental observations at local and regional scales using the devices and services of the Future Internet. These communities’ environmental observations represent a wealth of information which is currently hardly used or used only in isolation and therefore in need of integration with other information sources. Indeed, this very integration will lead to a paradigm shift from a mere Sensor Web to an Observation Web with semantically enriched content emanating from sensors, environmental simulations and citizens. The paper also describes the research challenges to realize the Observation Web and the associated environmental enablers for the Future Internet. Such an environmental enabler could for instance be an electronic sensing device, a web-service application, or even a social networking group affording or facilitating the capability of the Future Internet applications to consume, produce, and use environmental observations in cross-domain applications. The term “envirofied” Future Internet is coined to describe this overall target that forms a cornerstone of work in the Environmental Usage Area within the Future Internet PPP program. Relevant trends described in the paper are the usage of ubiquitous sensors (anywhere), the provision and generation of information by citizens, and the convergence of real and virtual realities to convey understanding of environmental observations. The paper addresses the technical challenges in the Environmental Usage Area and the need for designing multi-style service oriented architecture. Key topics are the mapping of requirements to capabilities, providing scalability and robustness with implementing context aware information retrieval. Another essential research topic is handling data fusion and model based computation, and the related propagation of information uncertainty. Approaches to security, standardization and harmonization, all essential for sustainable solutions, are summarized from the perspective of the Environmental Usage Area. The paper concludes with an overview of emerging, high impact applications in the environmental areas concerning land ecosystems (biodiversity), air quality (atmospheric conditions) and water ecosystems (marine asset management). PMID:22163827

Elucidating dark energy with future 21 cm observations at the epoch of reionization

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kohri, Kazunori; Oyama, Yoshihiko; Sekiguchi, Toyokazu

2017-02-01

We investigate how precisely we can determine the nature of dark energy such as the equation of state (EoS) and its time dependence by using future observations of 21 cm fluctuations at the epoch of reionization (06.8∼< z ∼<1) such as Square Kilometre Array (SKA) and Omniscope in combination with those from cosmic microwave background, baryon acoustic oscillation, type Ia supernovae and direct measurement of the Hubble constant. We consider several parametrizations for the EoS and find that future 21 cm observations will be powerful in constraining models of dark energy, especially when its EoS varies at high redshifts.

Geospatial intelligence and visual classification of environmentally observed species in the Future Internet

NASA Astrophysics Data System (ADS)

Arbab-Zavar, B.; Chakravarthy, A.; Sabeur, Z. A.

2012-04-01

The rapid development of advanced smart communication tools with good quality and resolution video cameras, audio and GPS devices in the last few years shall lead to profound impacts on the way future environmental observations are conducted and accessed by communities. The resulting large scale interconnections of these "Future Internet Things" form a large environmental sensing network which will generate large volumes of quality environmental observations and at highly localised spatial scales. This enablement in environmental sensing at local scales will be of great importance to contribute in the study of fauna and flora in the near future, particularly on the effect of climate change on biodiversity in various regions of Europe and beyond. The Future Internet could also potentially become the de facto information space to provide participative real-time sensing by communities and improve our situation awarness of the effect of climate on local environments. In the ENVIROFI(2011-2013) Usage Area project in the FP7 FI-PPP programme, a set of requirements for specific (and generic) enablers is achieved with the potential establishement of participating community observatories of the future. In particular, the specific enablement of interest concerns the building of future interoperable services for the management of environmental data intelligently with tagged contextual geo-spatial information generated by multiple operators in communities (Using smart phones). The classification of observed species in the resulting images is achieved with structured data pre-processing, semantic enrichement using contextual geospatial information, and high level fusion with controlled uncertainty estimations. The returned identification of species is further improved using future ground truth corrections and learning by the specific enablers.

Genesis Reentry Observations and Data Analysis

NASA Technical Reports Server (NTRS)

Suggs, R. M.; Swift, W. R.

2005-01-01

The Genesis spacecraft reentry represented a unique opportunity to observe a "calibrated meteor" from northern Nevada. Knowing its speed, mass, composition, and precise trajectory made it a good subject to test some of the algorithms used to determine meteoroid mass from observed brightness. It was also a good test of an inexpensive set of cameras that could be deployed to observe future shuttle reentries. The utility of consumer-grade video cameras was evident during the STS-107 accident investigation, and the Genesis reentry gave us the opportunity to specify and test commercially available cameras that could be used during future reentries. This Technical Memorandum describes the video observations and their analysis, compares the results with a simple photometric model, describes the forward scatter radar experiment, and lists lessons learned from the expedition and implications for the Stardust reentry in January 2006 as well as future shuttle reentries.

Local, Regional, and Global Albedo Variations on Mars From Recent Space-Based Observations: Implications for Future Human Explorers

NASA Astrophysics Data System (ADS)

Bell, J. F.; Wellington, D. F.

2017-06-01

We describe recent as well as historic albedo variations on Mars as observed by space-based telescopes, orbiters, and surface missions, and speculate that some regions might offer fewer dust-related problems for future human explorers than others.

Evidence for Future Cognition in Animals

ERIC Educational Resources Information Center

Roberts, William A.

2012-01-01

Evidence concerning the possibility of mental time travel into the future by animals was reviewed. Both experimental laboratory studies and field observations were considered. Paradigms for the study of future anticipation and planning included inhibition of consumption of current food contingent on future receipt of either a larger quantity or…

Medial Temporal Lobe Contributions to Episodic Future Thinking: Scene Construction or Future Projection?

PubMed

Palombo, D J; Hayes, S M; Peterson, K M; Keane, M M; Verfaellie, M

2018-02-01

Previous research has shown that the medial temporal lobes (MTL) are more strongly engaged when individuals think about the future than about the present, leading to the suggestion that future projection drives MTL engagement. However, future thinking tasks often involve scene processing, leaving open the alternative possibility that scene-construction demands, rather than future projection, are responsible for the MTL differences observed in prior work. This study explores this alternative account. Using functional magnetic resonance imaging, we directly contrasted MTL activity in 1) high scene-construction and low scene-construction imagination conditions matched in future thinking demands and 2) future-oriented and present-oriented imagination conditions matched in scene-construction demands. Consistent with the alternative account, the MTL was more active for the high versus low scene-construction condition. By contrast, MTL differences were not observed when comparing the future versus present conditions. Moreover, the magnitude of MTL activation was associated with the extent to which participants imagined a scene but was not associated with the extent to which participants thought about the future. These findings help disambiguate which component processes of imagination specifically involve the MTL. Published by Oxford University Press 2016.

Active optics as enabling technology for future large missions: current developments for astronomy and Earth observation at ESA

NASA Astrophysics Data System (ADS)

Hallibert, Pascal

2017-09-01

In recent years, a trend for higher resolution has increased the entrance apertures of future optical payloads for both Astronomy and Earth Observation most demanding applications, resulting in new opto-mechanical challenges for future systems based on either monolithic or segmented large primary mirrors. Whether easing feasibility and schedule impact of tight manufacturing and integration constraints or correcting mission-critical in-orbit and commissioning effects, Active Optics constitutes an enabling technology for future large optical space instruments at ESA and needs to reach the necessary maturity in time for future mission selection and implementation. We present here a complete updated overview of our current R and D activities in this field, ranging from deformable space-compatible components to full correction chains including wavefront sensing as well as control and correction algorithms. We share as well our perspectives on the way-forward to technological maturity and implementation within future missions.

Design and Application of an Electronic Logbook for Space System Integration and Test Operations

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kavelaars, Alicia T.

In the highly technological aerospace world paper is still widely used to document space system integration and test (I&T) operations. E-Logbook is a new technology designed to substitute the most commonly used paper logbooks in space system I&T, such as the connector mate/demate logbook, the flight hardware and flight software component installation logbook, the material mix record logbook and the electronic ground support equipment validation logbook. It also includes new logbook concepts, such as the shift logbook, which optimizes management oversight and the shift hand-over process, and the configuration logbook, which instantly reports on the global I&T state of themore » space system before major test events or project reviews. The design of E-Logbook focuses not only on a reliable and efficient relational database, but also on an ergonomic human-computer interactive (HCI) system that can help reduce human error and improve I&T management and oversight overall. E-Logbook has been used for the I&T operation of the Gamma-ray Large Area Space Telescope (GLAST) Large Area Telescope (LAT) at the Stanford Linear Accelerator Center (SLAC). More than 41,000 records have been created for the different I&T logbooks, with no data having been corrupted or critically lost. 94% of the operators and 100% of the management exposed to E-Logbook prefer it to paper logbooks and recommend its use in the aerospace industry.« less

The Impact of Current and Future Polar Orbiting Satellite Data on Numerical Weather Prediction at NASA/GSFC

NASA Technical Reports Server (NTRS)

Atlas, Robert

2004-01-01

The lack of adequate observational data continues to be recognized as a major factor limiting both atmospheric research and numerical prediction on a variety of temporal and spatial scales. Since the advent of meteorological satellites in the 1960's, a considerable research effort has been directed toward the design of space-borne meteorological sensors, the development of optimal methods for the utilization of these data, (and an assessment of the influence of existing satellite data and the potential influence of future satellite observations on numerical weather prediction. This has included both Observing System Experiments (OSEs) and Observing System Simulation Experiments (OSSEs). OSEs are conducted to evaluate the impact of specific observations or classes of observations on analyses and forecasts. While OSEs are performed with existing data, OSSEs are conducted to evaluate the potential for future observing systems to improve-NWP, as well as to evaluate trade-offs in observing system design, and to develop and test improved methods for data assimilation. At the conference, results from OSEs to evaluate satellite data sets that have recently become available to the global observing system, such as AIRS and Seawinds, and results from OSSEs to determine the potential impact of space-based lidar winds will be presented.

Sea Ice Summer Camp: Bringing Together Arctic Sea Ice Modelers and Observers

NASA Astrophysics Data System (ADS)

Perovich, D. K.; Holland, M. M.

2016-12-01

The Arctic sea ice has undergone dramatic change and numerical models project this to continue for the foreseeable future. Understanding the mechanisms behind sea ice loss and its consequences for the larger Arctic and global systems is of critical importance if we are to anticipate and plan for the future. One impediment to progress is a disconnect between the observational and modeling communities. A sea ice summer camp was held in Barrow Alaska from 26 May to 1 June 2016 to overcome this impediment and better integrate the sea ice community. The 25 participants were a mix of modelers and observers from 13 different institutions at career stages from graduate student to senior scientist. The summer camp provided an accelerated program on sea ice observations and models and also fostered future collaborative interdisciplinary activities. Each morning was spent in the classroom with a daily lecture on an aspect of modeling or remote sensing followed by practical exercises. Topics included using models to assess sensitivity, to test hypotheses and to explore sources of uncertainty in future Arctic sea ice loss. The afternoons were spent on the ice making observations. There were four observational activities; albedo observations, ice thickness measurements, ice coring and physical properties, and ice morphology surveys. The last field day consisted of a grand challenge where the group formulated a hypothesis, developed an observational and modeling strategy to test the hypothesis, and then integrated the observations and model results. The impacts of changing sea ice are being felt today in Barrow Alaska. We opened a dialog with Barrow community members to further understand these changes. This included an evening discussion with two Barrow sea ice experts and a community presentation of our work in a public lecture at the Inupiat Heritage Center.

QUANTIFYING AN UNCERTAIN FUTURE: HYDROLOGIC MODEL PERFORMANCE FOR A SERIES OF REALIZED "/FUTURE" CONDITIONS

EPA Science Inventory

A systematic analysis of model performance during simulations based on observed landcover/use change is used to quantify errors associated with simulations of known "future" conditions. Calibrated and uncalibrated assessments of relative change over different lengths of...

Electroweak precision observables and Higgs-boson signal strengths in the Standard Model and beyond: present and future

DOE PAGES

de Blas, J.; Ciuchini, M.; Franco, E.; ...

2016-12-27

We present results from a state-of-the-art fit of electroweak precision observables and Higgs-boson signal-strength measurements performed using 7 and 8 TeV data from the Large Hadron Collider. Based on the HEPfit package, our study updates the traditional fit of electroweak precision observables and extends it to include Higgs-boson measurements. As a result we obtain constraints on new physics corrections to both electroweak observables and Higgs-boson couplings. We present the projected accuracy of the fit taking into account the expected sensitivities at future colliders.

Electroweak precision observables and Higgs-boson signal strengths in the Standard Model and beyond: present and future

DOE Office of Scientific and Technical Information (OSTI.GOV)

de Blas, J.; Ciuchini, M.; Franco, E.

We present results from a state-of-the-art fit of electroweak precision observables and Higgs-boson signal-strength measurements performed using 7 and 8 TeV data from the Large Hadron Collider. Based on the HEPfit package, our study updates the traditional fit of electroweak precision observables and extends it to include Higgs-boson measurements. As a result we obtain constraints on new physics corrections to both electroweak observables and Higgs-boson couplings. We present the projected accuracy of the fit taking into account the expected sensitivities at future colliders.

The Future of Satellite-based Lightning Detection

NASA Technical Reports Server (NTRS)

Bocippio, Dennis J.; Christian, Hugh J.; Arnold, James E. (Technical Monitor)

2001-01-01

The future of satellite-based optical lightning detection, beyond the end of the current TRMM mission, is discussed. Opportunities for new low-earth orbit missions are reviewed. The potential for geostationary observations is significant; such observations provide order-of-magnitude gains in sampling and data efficiency over existing satellite convective observations. The feasibility and performance (resolution, sensitivity) of geostationary measurements using current technology is discussed. In addition to direct and continuous hemispheric observation of lighting, geostationary measurements have the potential (through data assimilation) to dramatically improve short and medium range forecasts, offering benefits to prediction of NOx productions and/or vertical transport.

Sustained UK marine observations. Where have we been? Where are we now? Where are we going?

PubMed Central

Owens, Nicholas J. P.

2014-01-01

This introduction traces the earliest interaction of ancient humans with their marine environment, through marine explorations in the Middle Ages and Renaissance, to the development of early marine science in the Enlightenment. This sets the scene for how marine observations developed in the modern era and explains the status of today's marine observation networks. The paper concludes with an assessment of the future needs and constraints of sustained marine observation networks and suggests the lessons from a long history might be the key to the future. PMID:25157193

Concluding Remarks: The Current Status and Future Prospects for GRB Astronomy

NASA Technical Reports Server (NTRS)

Gehrels, Neil

2009-01-01

We are in a remarkable period of discovery in GRB astronomy. The current satellites including Swift, Fermi. AGILE and INTEGRAL are detecting and observing bursts of all varieties. Increasing capabilities for follow-up observations on the ground and in space are leading to rapid and deep coverage across the electromagnetic spectrum, The future will see continued operation of the current experiments and with future missions like SVOM plus possible rni_Ssions like JANUS and EXIST. An exciting expansion of capabilities is occurring in areas of gravitational waves and neutrinos that could open new windows on the GRB phenomenon. Increased IR capabilities on the ground and with missions like JWST will enable further exploration of high redshift bursts. The future is bright.

Predicting future uncertainty constraints on global warming projections

DOE PAGES

Shiogama, H.; Stone, D.; Emori, S.; ...

2016-01-11

Projections of global mean temperature changes (ΔT) in the future are associated with intrinsic uncertainties. Much climate policy discourse has been guided by "current knowledge" of the ΔTs uncertainty, ignoring the likely future reductions of the uncertainty, because a mechanism for predicting these reductions is lacking. By using simulations of Global Climate Models from the Coupled Model Intercomparison Project Phase 5 ensemble as pseudo past and future observations, we estimate how fast and in what way the uncertainties of ΔT can decline when the current observation network of surface air temperature is maintained. At least in the world of pseudomore » observations under the Representative Concentration Pathways (RCPs), we can drastically reduce more than 50% of the ΔTs uncertainty in the 2040 s by 2029, and more than 60% of the ΔTs uncertainty in the 2090 s by 2049. Under the highest forcing scenario of RCPs, we can predict the true timing of passing the 2°C (3°C) warming threshold 20 (30) years in advance with errors less than 10 years. These results demonstrate potential for sequential decision-making strategies to take advantage of future progress in understanding of anthropogenic climate change.« less

Predicting future uncertainty constraints on global warming projections

PubMed Central

Shiogama, H.; Stone, D.; Emori, S.; Takahashi, K.; Mori, S.; Maeda, A.; Ishizaki, Y.; Allen, M. R.

2016-01-01

Projections of global mean temperature changes (ΔT) in the future are associated with intrinsic uncertainties. Much climate policy discourse has been guided by “current knowledge” of the ΔTs uncertainty, ignoring the likely future reductions of the uncertainty, because a mechanism for predicting these reductions is lacking. By using simulations of Global Climate Models from the Coupled Model Intercomparison Project Phase 5 ensemble as pseudo past and future observations, we estimate how fast and in what way the uncertainties of ΔT can decline when the current observation network of surface air temperature is maintained. At least in the world of pseudo observations under the Representative Concentration Pathways (RCPs), we can drastically reduce more than 50% of the ΔTs uncertainty in the 2040 s by 2029, and more than 60% of the ΔTs uncertainty in the 2090 s by 2049. Under the highest forcing scenario of RCPs, we can predict the true timing of passing the 2 °C (3 °C) warming threshold 20 (30) years in advance with errors less than 10 years. These results demonstrate potential for sequential decision-making strategies to take advantage of future progress in understanding of anthropogenic climate change. PMID:26750491

Predicting future uncertainty constraints on global warming projections

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shiogama, H.; Stone, D.; Emori, S.

Projections of global mean temperature changes (ΔT) in the future are associated with intrinsic uncertainties. Much climate policy discourse has been guided by "current knowledge" of the ΔTs uncertainty, ignoring the likely future reductions of the uncertainty, because a mechanism for predicting these reductions is lacking. By using simulations of Global Climate Models from the Coupled Model Intercomparison Project Phase 5 ensemble as pseudo past and future observations, we estimate how fast and in what way the uncertainties of ΔT can decline when the current observation network of surface air temperature is maintained. At least in the world of pseudomore » observations under the Representative Concentration Pathways (RCPs), we can drastically reduce more than 50% of the ΔTs uncertainty in the 2040 s by 2029, and more than 60% of the ΔTs uncertainty in the 2090 s by 2049. Under the highest forcing scenario of RCPs, we can predict the true timing of passing the 2°C (3°C) warming threshold 20 (30) years in advance with errors less than 10 years. These results demonstrate potential for sequential decision-making strategies to take advantage of future progress in understanding of anthropogenic climate change.« less

The Future of Education and the Future of Work.

ERIC Educational Resources Information Center

Bruce, Michael G.

1984-01-01

Observing that there is no shortage of work to be done, but rather a shortage of employment, this essay analyzes aspects of youth unemployment in Europe including school effectiveness; alienation and the work ethic; remedies, which include European Community's "social guarantee"; and some considerations for future change. (MJL)

An Adjoint-Based Analysis of the Sampling Footprints of Tall Tower, Aircraft and Potential Future Lidar Observations of CO2

NASA Technical Reports Server (NTRS)

Andrews, Arlyn; Kawa, Randy; Zhu, Zhengxin; Burris, John; Abshire, Jim

2004-01-01

A detailed mechanistic understanding of the sources and sinks of CO2 will be required to reliably predict future CO2 levels and climate. A commonly used technique for deriving information about CO2 exchange with surface reservoirs is to solve an 'inverse problem', where CO2 observations are used with an atmospheric transport model to find the optimal distribution of sources and sinks. Synthesis inversion methods are powerful tools for addressing this question, but the results are disturbingly sensitive to the details of the calculation. Studies done using different atmospheric transport models and combinations of surface station data have produced substantially different distributions of surface fluxes. Adjoint methods are now being developed that will more effectively incorporate diverse datasets in estimates of surface fluxes of CO2. In an adjoint framework, it will be possible to combine CO2 concentration data from longterm surface and aircraft monitoring stations with data from intensive field campaigns and with proposed future satellite observations. We have recently developed an adjoint for the GSFC 3-D Parameterized Chemistry and Transport Model (PCTM). Here, we will present results from a PCTM Adjoint study comparing the sampling footprints of tall tower, aircraft and potential future lidar observations of CO2. The vertical resolution and extent of the profiles and the observation frequency will be considered for several sites in North America.

Smoothness of the future and past trapped sets in Kerr–Newman–Taub-NUT spacetimes

NASA Astrophysics Data System (ADS)

Paganini, Claudio F.; Oancea, Marius A.

2018-03-01

We consider the sets of future/past trapped null geodesics in the exterior region of a sub-extremal Kerr–Newman–Taub-NUT spacetime. We show that from the point of view of any timelike observer outside of such a black hole, trapping can be understood as two smooth sets of spacelike directions on the celestial sphere of the observer.

Sustained UK marine observations. Where have we been? Where are we now? Where are we going?

PubMed

Owens, Nicholas J P

2014-09-28

This introduction traces the earliest interaction of ancient humans with their marine environment, through marine explorations in the Middle Ages and Renaissance, to the development of early marine science in the Enlightenment. This sets the scene for how marine observations developed in the modern era and explains the status of today's marine observation networks. The paper concludes with an assessment of the future needs and constraints of sustained marine observation networks and suggests the lessons from a long history might be the key to the future. © 2014 The Author(s) Published by the Royal Society. All rights reserved.

To qualify as a social partner, humans hide severe punishment, although their observed cooperativeness is decisive.

PubMed

Rockenbach, Bettina; Milinski, Manfred

2011-11-08

Conflicts of interest between the community and its members are at the core of human social dilemmas. If observed selfishness has future costs, individuals may hide selfish acts but display altruistic ones, and peers aim at identifying the most selfish persons to avoid them as future social partners. An interaction involving hiding and seeking information may be inevitable. We staged an experimental social-dilemma game in which actors could pay to conceal information about their contribution, giving, and punishing decisions from an observer who selects her future social partners from the actors. The observer could pay to conceal her observation of the actors. We found sophisticated dynamic strategies on either side. Actors hide their severe punishment and low contributions but display high contributions. Observers select high contributors as social partners; remarkably, punishment behavior seems irrelevant for qualifying as a social partner. That actors nonetheless pay to conceal their severe punishment adds a further puzzle to the role of punishment in human social behavior. Competition between hiding and seeking information about social behavior may be even more relevant and elaborate in the real world but usually is hidden from our eyes.

Evaluation of climatic changes in South-Asia

NASA Astrophysics Data System (ADS)

Kjellstrom, Erik; Rana, Arun; Grigory, Nikulin; Renate, Wilcke; Hansson, Ulf; Kolax, Michael

2016-04-01

Literature has sufficient evidences of climate change impact all over the world and its impact on various sectors. In light of new advancements made in climate modeling, availability of several climate downscaling approaches, the more robust bias correction methods with varying complexities and strengths, in the present study we performed a systematic evaluation of climate change impact over South-Asia region. We have used different Regional Climate Models (RCMs) (from CORDEX domain), (Global Climate Models GCMs) and gridded observations for the study area to evaluate the models in historical/control period (1980-2010) and changes in future period (2010-2099). Firstly, GCMs and RCMs are evaluated against the Gridded observational datasets in the area using precipitation and temperature as indicative variables. Observational dataset are also evaluated against the reliable set of observational dataset, as pointed in literature. Bias, Correlation, and changes (among other statistical measures) are calculated for the entire region and both the variables. Eventually, the region was sub-divided into various smaller domains based on homogenous precipitation zones to evaluate the average changes over time period. Spatial and temporal changes for the region are then finally calculated to evaluate the future changes in the region. Future changes are calculated for 2 Representative Concentration Pathways (RCPs), the middle emission (RCP4.5) and high emission (RCP8.5) and for both climatic variables, precipitation and temperature. Lastly, Evaluation of Extremes is performed based on precipitation and temperature based indices for whole region in future dataset. Results have indicated that the whole study region is under extreme stress in future climate scenarios for both climatic variables i.e. precipitation and temperature. Precipitation variability is dependent on the location in the area leading to droughts and floods in various regions in future. Temperature is hinting towards a constant increase throughout the region regardless of location.

Theoretical physics implications of gravitational wave observation with future detectors

NASA Astrophysics Data System (ADS)

Chamberlain, Katie; Yunes, Nicolás

2017-10-01

Gravitational waves encode invaluable information about the nature of the relatively unexplored extreme gravity regime, where the gravitational interaction is strong, nonlinear and highly dynamical. Recent gravitational wave observations by advanced LIGO have provided the first glimpses into this regime, allowing for the extraction of new inferences on different aspects of theoretical physics. For example, these detections provide constraints on the mass of the graviton, Lorentz violation in the gravitational sector, the existence of large extra dimensions, the temporal variability of Newton's gravitational constant, and modified dispersion relations of gravitational waves. Many of these constraints, however, are not yet competitive with constraints obtained, for example, through Solar System observations or binary pulsar observations. In this paper, we study the degree to which theoretical physics inferences drawn from gravitational wave observations will strengthen with detections from future detectors. We consider future ground-based detectors, such as the LIGO-class expansions A + , Voyager, Cosmic Explorer and the Einstein Telescope, as well as space-based detectors, such as various configurations of eLISA and the recently proposed LISA mission. We find that space-based detectors will place constraints on general relativity up to 12 orders of magnitude more stringently than current aLIGO bounds, but these space-based constraints are comparable to those obtained with the ground-based Cosmic Explorer or the Einstein Telescope (A + and Voyager only lead to modest improvements in constraints). We also generically find that improvements in the instrument sensitivity band at low frequencies lead to large improvements in certain classes of constraints, while sensitivity improvements at high frequencies lead to more modest gains. These results strengthen the case for the development of future detectors, while providing additional information that could be useful in future design decisions.

Observation impact studies with the Mercator Ocean analysis and forecasting systems

NASA Astrophysics Data System (ADS)

Remy, E. D.; Le Traon, P. Y.; Lellouche, J. M.; Drevillon, M.; Turpin, V.; Benkiran, M.

2016-02-01

Mercator Ocean produces and delivers in real-time ocean analysis and forecasts on a daily basis. The quality of the analysis highly relies on the availability and quality of the assimilated observations.Tools are developed to estimate the impact of the present network and to help designing the future evolutions of the observing systems in the context of near real time production of ocean analysis and forecasts. OSE and OSSE are the main approaches used in this context. They allow the assessment of the efficiency of a given data set to constrain the ocean model circulation through the data assimilation process. Illustrations will mainly focus on the present and future evolution of the Argo observation network and altimetry constellation, including the potential impact of future SWOT data. Our systems show clear sensitivities to observation array changes, mainly depending on the specified observation error and regional dynamic. Impact on non observed variables can be important and are important to evaluate. Dedicated diagnostics has to be define to measure the improvements bring by each data set. Alternative approaches to OSE and OSSE are also explored: approximate computation of DFS will be presented and discussed. Limitations of each approach will be discussed in the context of real time operation.

About the Federal Energy Management Program

DOE Office of Scientific and Technical Information (OSTI.GOV)

Richard Kidd

2009-04-23

Richard Kidd, Program Manager for the Federal Energy Management Program (FEMP), presents a discussion on FEMP direction and its future role, federal funding trends, future financing trends, and Earth Day observations.

Past and future changes in climate and hydrological indicators in the US Northeast

USGS Publications Warehouse

Hayhoe, K.; Wake, C.P.; Huntington, T.G.; Luo, L.; Schwartz, M.D.; Sheffield, J.; Wood, E.; Anderson, B.; Bradbury, J.; DeGaetano, A.; Troy, T.J.; Wolfe, D.

2007-01-01

To assess the influence of global climate change at the regional scale, we examine past and future changes in key climate, hydrological, and biophysical indicators across the US Northeast (NE). We first consider the extent to which simulations of twentieth century climate from nine atmosphere-ocean general circulation models (AOGCMs) are able to reproduce observed changes in these indicators. We then evaluate projected future trends in primary climate characteristics and indicators of change, including seasonal temperatures, rainfall and drought, snow cover, soil moisture, streamflow, and changes in biometeorological indicators that depend on threshold or accumulated temperatures such as growing season, frost days, and Spring Indices (SI). Changes in indicators for which temperature-related signals have already been observed (seasonal warming patterns, advances in high-spring streamflow, decreases in snow depth, extended growing seasons, earlier bloom dates) are generally reproduced by past model simulations and are projected to continue in the future. Other indicators for which trends have not yet been observed also show projected future changes consistent with a warmer climate (shrinking snow cover, more frequent droughts, and extended low-flow periods in summer). The magnitude of temperature-driven trends in the future are generally projected to be higher under the Special Report on Emission Scenarios (SRES) mid-high (A2) and higher (A1FI) emissions scenarios than under the lower (B1) scenario. These results provide confidence regarding the direction of many regional climate trends, and highlight the fundamental role of future emissions in determining the potential magnitude of changes we can expect over the coming century. ?? Springer-Verlag 2006.

Not my future? Core values and the neural representation of future events.

PubMed

Brosch, Tobias; Stussi, Yoann; Desrichard, Olivier; Sander, David

2018-06-01

Individuals with pronounced self-transcendence values have been shown to put greater weight on the long-term consequences of their actions when making decisions. Using functional magnetic resonance imaging, we investigated the neural mechanisms underlying the evaluation of events occurring several decades in the future as well as the role of core values in these processes. Thirty-six participants viewed a series of events, consisting of potential consequences of climate change, which could occur in the near future (around 2030), and thus would be experienced by the participants themselves, or in the far future (around 2080). We observed increased activation in anterior VMPFC (BA11), a region involved in encoding the personal significance of future events, when participants were envisioning far future events, demonstrating for the first time that the role of the VMPFC in future projection extends to the time scale of decades. Importantly, this activation increase was observed only in participants with pronounced self-transcendence values measured by self-report questionnaire, as shown by a statistically significant interaction of temporal distance and value structure. These findings suggest that future projection mechanisms are modulated by self-transcendence values to allow for a more extensive simulation of far future events. Consistent with this, these participants reported similar concern ratings for near and far future events, whereas participants with pronounced self-enhancement values were more concerned about near future events. Our findings provide a neural substrate for the tendency of individuals with pronounced self-transcendence values to consider the long-term consequences of their actions.

Species distribution modeling based on the automated identification of citizen observations.

PubMed

Botella, Christophe; Joly, Alexis; Bonnet, Pierre; Monestiez, Pascal; Munoz, François

2018-02-01

A species distribution model computed with automatically identified plant observations was developed and evaluated to contribute to future ecological studies. We used deep learning techniques to automatically identify opportunistic plant observations made by citizens through a popular mobile application. We compared species distribution modeling of invasive alien plants based on these data to inventories made by experts. The trained models have a reasonable predictive effectiveness for some species, but they are biased by the massive presence of cultivated specimens. The method proposed here allows for fine-grained and regular monitoring of some species of interest based on opportunistic observations. More in-depth investigation of the typology of the observations and the sampling bias should help improve the approach in the future.

The Future of Scientific Computing

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hendrickson, Bruce A.

Attempts to predict the future have a long and inglorious history. Also, cultures from time immemorial have devoted their very best technologies to the task, utilizing apparatuses such as tea leaves, crystal balls, and animal entrails. But as Niels Bohr famously observed, “prediction is very difficult, especially if it’s about the future.”

The Future of Scientific Computing

DOE PAGES

Hendrickson, Bruce A.

2017-10-04

Attempts to predict the future have a long and inglorious history. Also, cultures from time immemorial have devoted their very best technologies to the task, utilizing apparatuses such as tea leaves, crystal balls, and animal entrails. But as Niels Bohr famously observed, “prediction is very difficult, especially if it’s about the future.”

MOEMs-based new functionalities for future instrumentation in space

NASA Astrophysics Data System (ADS)

Zamkotsian, Frédéric; Liotard, Arnaud; Viard, Thierry; Costes, Vincent; Hébert, Philippe-Jean; Hinglais, Emmanuel; Villenave, Michel

2017-11-01

Micro-Opto-Electro-Mechanical Systems (MOEMS) could be key components in future generation of space instruments. In Earth Observation, Universe Observation and Planet Exploration, scientific return of the instruments must be optimized in future missions. MOEMS devices are based on the mature micro-electronics technology and in addition to their compactness, scalability, and specific task customization, they could generate new functions not available with current technologies. CNES has initiated a study with LAM and TAS for listing the new functions associated with several types of MEMS (programmable slits, programmable micro-diffraction gratings, micro-deformable mirrors). Instrumental applications are then derived and promising concepts are described.

NASA's ultraviolet astrophysics branch - The next decade

NASA Technical Reports Server (NTRS)

Welsh, Barry Y.; Kaplan, Michael

1992-01-01

We review some of the mission concepts currently being considered by NASA's Astrophysics Division to carry out future observations in the 100-3000 Angstrom region. Examples of possible future missions include UV and visible interferometric experiments, a next generation Space Telescope and lunar-based UV instrumentation. In order to match the science objectives of these future missions with new observational techniques, critical technology needs in the ultraviolet regime have been identified. Here we describe how NASA's Astrophysics Division Advanced Programs Branch is attempting to formulate an integrated technology plan called the 'Astrotech 21' program in order to provide the technology base for these astrophysics missions of the 21st century.

Drivers' communicative interactions: on-road observations and modelling for integration in future automation systems.

PubMed

Portouli, Evangelia; Nathanael, Dimitris; Marmaras, Nicolas

2014-01-01

Social interactions with other road users are an essential component of the driving activity and may prove critical in view of future automation systems; still up to now they have received only limited attention in the scientific literature. In this paper, it is argued that drivers base their anticipations about the traffic scene to a large extent on observations of social behaviour of other 'animate human-vehicles'. It is further argued that in cases of uncertainty, drivers seek to establish a mutual situational awareness through deliberate communicative interactions. A linguistic model is proposed for modelling these communicative interactions. Empirical evidence from on-road observations and analysis of concurrent running commentary by 25 experienced drivers support the proposed model. It is suggested that the integration of a social interactions layer based on illocutionary acts in future driving support and automation systems will improve their performance towards matching human driver's expectations. Practitioner Summary: Interactions between drivers on the road may play a significant role in traffic coordination. On-road observations and running commentaries are presented as empirical evidence to support a model of such interactions; incorporation of drivers' interactions in future driving support and automation systems may improve their performance towards matching driver's expectations.

Rapid sodium signaling couples glutamate uptake to breakdown of ATP in perivascular astrocyte endfeet.

PubMed

Langer, Julia; Gerkau, Niklas J; Derouiche, Amin; Kleinhans, Christian; Moshrefi-Ravasdjani, Behrouz; Fredrich, Michaela; Kafitz, Karl W; Seifert, Gerald; Steinhäuser, Christian; Rose, Christine R

2017-02-01

Perivascular endfeet of astrocytes are highly polarized compartments that ensheath blood vessels and contribute to the blood-brain barrier. They experience calcium transients with neuronal activity, a phenomenon involved in neurovascular coupling. Endfeet also mediate the uptake of glucose from the blood, a process stimulated in active brain regions. Here, we demonstrate in mouse hippocampal tissue slices that endfeet undergo sodium signaling upon stimulation of glutamatergic synaptic activity. Glutamate-induced endfeet sodium transients were diminished by TFB-TBOA, suggesting that they were generated by sodium-dependent glutamate uptake. With local agonist application, they could be restricted to endfeet and immunohistochemical analysis revealed prominent expression of glutamate transporters GLAST and GLT-1 localized towards the neuropil vs. the vascular side of endfeet. Endfeet sodium signals spread at an apparent maximum velocity of ∼120 µm/s and directly propagated from stimulated into neighboring endfeet; this spread was omitted in Cx30/Cx43 double-deficient mice. Sodium transients resulted in elevation of intracellular magnesium, indicating a decrease in intracellular ATP. In summary, our results establish that excitatory synaptic activity and stimulation of glutamate uptake in astrocytes trigger transient sodium increases in perivascular endfeet which rapidly spread through gap junctions into neighboring endfeet and cause a reduction of intracellular ATP. The newly discovered endfeet sodium signaling thereby represents a fast, long-lived and inter-cellularly acting indicator of synaptic activity at the blood-brain barrier, which likely constitutes an important component of neuro-metabolic coupling in the brain. GLIA 2017;65:293-308. © 2016 Wiley Periodicals, Inc.

Laquinimod ameliorates excitotoxic damage by regulating glutamate re-uptake.

PubMed

Gentile, Antonietta; Musella, Alessandra; De Vito, Francesca; Fresegna, Diego; Bullitta, Silvia; Rizzo, Francesca Romana; Centonze, Diego; Mandolesi, Georgia

2018-01-05

Laquinimod is an immunomodulatory drug under clinical investigation for the treatment of the progressive form of multiple sclerosis (MS) with both anti-inflammatory and neuroprotective effects. Excitotoxicity, a prominent pathophysiological feature of MS and of its animal model, experimental autoimmune encephalomyelitis (EAE), involves glutamate transporter (GluT) dysfunction in glial cells. The aim of this study was to assess whether laquinimod might exert direct neuroprotective effects by interfering with the mechanisms of excitotoxicity linked to GluT function impairments in EAE. Osmotic minipumps allowing continuous intracerebroventricular (icv) infusion of laquinimod for 4 weeks were implanted into C57BL/6 mice before EAE induction. EAE cerebella were taken to perform western blot and qPCR experiments. For ex vivo experiments, EAE cerebellar slices were incubated with laquinimod before performing electrophysiology, western blot, and qPCR. In vivo treatment with laquinimod attenuated EAE clinical score at the peak of the disease, without remarkable effects on inflammatory markers. In vitro application of laquinimod to EAE cerebellar slices prevented EAE-linked glutamatergic alterations without mitigating astrogliosis and inflammation. Moreover, such treatment induced an increase of Slcla3 mRNA coding for the glial glutamate-aspartate transporter (GLAST) without affecting the protein content. Concomitantly, laquinimod significantly increased the levels of the glial glutamate transporter 1 (GLT-1) protein and pharmacological blockade of GLT-1 function fully abolished laquinimod anti-excitotoxic effect. Overall, our results suggest that laquinimod protects against glutamate excitotoxicity of the cerebellum of EAE mice by bursting the expression of glial glutamate transporters, independently of its anti-inflammatory effects.

The ARGO Project

NASA Astrophysics Data System (ADS)

Kozameh, C. N.

El proyecto µARGO propone el desarrollo, construcción y operación del Observatorio Espacial de Rayos Gamma, que operará en una órbita terrestre. Este observatorio constará de un telescopio con capacidad de medir simultáneamente dirección de incidencia y polarización de rayos Gamma en dos rangos de energía: 50 KeV - 3 MeV y 10 MeV - 1 GeV. Para ello se usarán detectores de silicio de última generación y microelectrónica adaptada a la configuración. La masa total en órbita del observatorio estará en el orden de los 60 - 100 kg. dependiendo de la geometría adoptada lo que permitirá minimizar costos de desarrollo y construcción, sin perder por ello calidad en su misión científica. ? Desde el punto de vista energético μARGO cubrirá el rango cubierto por COMPTEL y EGRET del CGRO, duplicando como mínimo la resolución angular de ambos con una reducción de peso de dos órdenes de magnitud. En adición, μARGO podr´ medir la polarización incidente de los rayos energéticos. Si bien existen otros dos proyectos en marcha (GLAST y AGILE) para reemplazar EGRET que serán lanzados antes que μARGO, estos proyectos no están diseñados para medir polarización ni tampoco cubren el rango mas bajo de energía arriba mencionado.

Neurological effects of inorganic arsenic exposure: altered cysteine/glutamate transport, NMDA expression and spatial memory impairment.

PubMed

Ramos-Chávez, Lucio A; Rendón-López, Christian R R; Zepeda, Angélica; Silva-Adaya, Daniela; Del Razo, Luz M; Gonsebatt, María E

2015-01-01

Inorganic arsenic (iAs) is an important natural pollutant. Millions of individuals worldwide drink water with high levels of iAs. Chronic exposure to iAs has been associated with lower IQ and learning disabilities as well as memory impairment. iAs is methylated in tissues such as the brain generating mono and dimethylated species. iAs methylation requires cellular glutathione (GSH), which is the main antioxidant in the central nervous system (CNS). In humans, As species cross the placenta and are found in cord blood. A CD1 mouse model was used to investigate effects of gestational iAs exposure which can lead to oxidative damage, disrupted cysteine/glutamate transport and its putative impact in learning and memory. On postnatal days (PNDs) 1, 15 and 90, the expression of membrane transporters related to GSH synthesis and glutamate transport and toxicity, such as xCT, EAAC1, GLAST and GLT1, as well as LAT1, were analyzed. Also, the expression of the glutamate receptor N-methyl-D-aspartate (NMDAR) subunits NR2A and B as well as the presence of As species in cortex and hippocampus were investigated. On PND 90, an object location task was performed to associate exposure with memory impairment. Gestational exposure to iAs affected the expression of cysteine/glutamate transporters in cortex and hippocampus and induced a negative modulation of NMDAR NR2B subunit in the hippocampus. Behavioral tasks showed significant spatial memory impairment in males while the effect was marginal in females.

Neurological effects of inorganic arsenic exposure: altered cysteine/glutamate transport, NMDA expression and spatial memory impairment

PubMed Central

Ramos-Chávez, Lucio A.; Rendón-López, Christian R. R.; Zepeda, Angélica; Silva-Adaya, Daniela; Del Razo, Luz M.; Gonsebatt, María E.

2015-01-01

Inorganic arsenic (iAs) is an important natural pollutant. Millions of individuals worldwide drink water with high levels of iAs. Chronic exposure to iAs has been associated with lower IQ and learning disabilities as well as memory impairment. iAs is methylated in tissues such as the brain generating mono and dimethylated species. iAs methylation requires cellular glutathione (GSH), which is the main antioxidant in the central nervous system (CNS). In humans, As species cross the placenta and are found in cord blood. A CD1 mouse model was used to investigate effects of gestational iAs exposure which can lead to oxidative damage, disrupted cysteine/glutamate transport and its putative impact in learning and memory. On postnatal days (PNDs) 1, 15 and 90, the expression of membrane transporters related to GSH synthesis and glutamate transport and toxicity, such as xCT, EAAC1, GLAST and GLT1, as well as LAT1, were analyzed. Also, the expression of the glutamate receptor N-methyl-D-aspartate (NMDAR) subunits NR2A and B as well as the presence of As species in cortex and hippocampus were investigated. On PND 90, an object location task was performed to associate exposure with memory impairment. Gestational exposure to iAs affected the expression of cysteine/glutamate transporters in cortex and hippocampus and induced a negative modulation of NMDAR NR2B subunit in the hippocampus. Behavioral tasks showed significant spatial memory impairment in males while the effect was marginal in females. PMID:25709567

GLAST Burst Monitor Signal Processing System

NASA Astrophysics Data System (ADS)

Bhat, P. Narayana; Briggs, Michael; Connaughton, Valerie; Diehl, Roland; Fishman, Gerald; Greiner, Jochen; Kippen, R. Marc; von Kienlin, Andreas; Kouveliotou, Chryssa; Lichti, Giselher; Meegan, Charles; Paciesas, William; Persyn, Steven; Preece, Robert; Steinle, Helmut; Wilson-Hodge, Colleen

2007-07-01

The onboard Data Processing Unit (DPU), designed and built by Southwest Research Institute, performs the high-speed data acquisition for GBM. The analog signals from each of the 14 detectors are digitized by high-speed multichannel analog data acquisition architecture. The streaming digital values resulting from a periodic (period of 104.2 ns) sampling of the analog signal by the individual ADCs are fed to a Field-Programmable Gate Array (FPGA). Real-time Digital Signal Processing (DSP) algorithms within the FPGA implement functions like filtering, thresholding, time delay and pulse height measurement. The spectral data with a 12-bit resolution are formatted according to the commandable look-up-table (LUT) and then sent to the High-Speed Science-Date Bus (HSSDB, speed=1.5 MB/s) to be telemetered to ground. The DSP offers a novel feature of a commandable & constant event deadtime. The ADC non-linearities have been calibrated so that the spectral data can be corrected during analysis. The best temporal resolution is 2 μs for the pre-burst & post-trigger time-tagged events (TTE) data. The time resolution of the binned data types is commandable from 64 msec to 1.024 s for the CTIME data (8 channel spectral resolution) and 1.024 to 32.768 s for the CSPEC data (128 channel spectral resolution). The pulse pile-up effects have been studied by Monte Carlo simulations. For a typical GRB, the possible shift in the Epeak value at high-count rates (~100 kHz) is ~1% while the change in the single power-law index could be up to 5%.

The origin of the diffuse background gamma radiation

NASA Technical Reports Server (NTRS)

Stecker, F. W.; Puget, J. L.

1974-01-01

Recent observations provided evidence for diffuse background gamma radiation extending to energies beyond 100 MeV, and evidence of isotropy and implied cosmological origin. Significant features in the spectrum of this background radiation were observed which provide evidence for its origin in nuclear processes in the early stages of big-bang cosmology, and connect these processes with the galaxy formation theory. A test of the theory is in future observations of the background radiation in the 100 MeK to 100 GeV energy range which are made with large orbiting spark-chamber satellite detectors. The theoretical interpretations of present data, their connection with baryon-symmetric cosmology and galaxy formation theory, and the need for future observations are discussed.

SOFIA: A Promising Resource for Future Nova Studies

NASA Astrophysics Data System (ADS)

Helton, L. A.; Sofia Science Team

2014-12-01

The Stratospheric Observatory for Infrared Astronomy (SOFIA) is a 2.5-m telescope carried on board a Boeing 747-SP aircraft. Optimized for observations from infrared through sub-mm wavelengths, SOFIA observes from an altitude of 37,000 - 45,000 feet, above 99% of the atmospheric water vapor. The Observatory's complement of instruments possesses a broad range of capabilities, many of which are especially well suited for observations of classical novae, recurrent novae, and other cataclysmic variables. Here we present a selection of the instruments available on board SOFIA that may prove to be very useful for future novae studies.

Linear and non-linear Modified Gravity forecasts with future surveys

NASA Astrophysics Data System (ADS)

Casas, Santiago; Kunz, Martin; Martinelli, Matteo; Pettorino, Valeria

2017-12-01

Modified Gravity theories generally affect the Poisson equation and the gravitational slip in an observable way, that can be parameterized by two generic functions (η and μ) of time and space. We bin their time dependence in redshift and present forecasts on each bin for future surveys like Euclid. We consider both Galaxy Clustering and Weak Lensing surveys, showing the impact of the non-linear regime, with two different semi-analytical approximations. In addition to these future observables, we use a prior covariance matrix derived from the Planck observations of the Cosmic Microwave Background. In this work we neglect the information from the cross correlation of these observables, and treat them as independent. Our results show that η and μ in different redshift bins are significantly correlated, but including non-linear scales reduces or even eliminates the correlation, breaking the degeneracy between Modified Gravity parameters and the overall amplitude of the matter power spectrum. We further apply a Zero-phase Component Analysis and identify which combinations of the Modified Gravity parameter amplitudes, in different redshift bins, are best constrained by future surveys. We extend the analysis to two particular parameterizations of μ and η and consider, in addition to Euclid, also SKA1, SKA2, DESI: we find in this case that future surveys will be able to constrain the current values of η and μ at the 2-5% level when using only linear scales (wavevector k < 0 . 15 h/Mpc), depending on the specific time parameterization; sensitivity improves to about 1% when non-linearities are included.

Datasets on hub-height wind speed comparisons for wind farms in California.

PubMed

Wang, Meina; Ullrich, Paul; Millstein, Dev

2018-08-01

This article includes the description of data information related to the research article entitled "The future of wind energy in California: Future projections with the Variable-Resolution CESM"[1], with reference number RENE_RENE-D-17-03392. Datasets from the Variable-Resolution CESM, Det Norske Veritas Germanischer Lloyd Virtual Met, MERRA-2, CFSR, NARR, ISD surface observations, and upper air sounding observations were used for calculating and comparing hub-height wind speed at multiple major wind farms across California. Information on hub-height wind speed interpolation and power curves at each wind farm sites are also presented. All datasets, except Det Norske Veritas Germanischer Lloyd Virtual Met, are publicly available for future analysis.

ORAC: 21st Century Observing at UKIRT

NASA Astrophysics Data System (ADS)

Bridger, A.; Wright, G. S.; Tan, M.; Pickup, D. A.; Economou, F.; Currie, M. J.; Adamson, A. J.; Rees, N. P.; Purves, M. H.

The Observatory Reduction and Acquisition Control system replaces all of the existing software which interacts with the observers at UKIRT. The aim is to improve observing efficiency with a set of integrated tools that take the user from pre-observing preparation, through the acquisition of observations to the reduction using a data-driven pipeline. ORAC is designed to be flexible and extensible, and is intended for use with all future UKIRT instruments, as well as existing telescope hardware and ``legacy'' instruments. It is also designed to allow integration with phase-1 and queue-scheduled observing tools in anticipation of possible future requirements. A brief overview of the project and its relationship to other systems is given. ORAC also re-uses much code from other systems and we discuss issues relating to the trade-off between reuse and the generation of new software specific to our requirements.

Australia's Unprecedented Future Temperature Extremes Under Paris Limits to Warming

NASA Astrophysics Data System (ADS)

Lewis, Sophie C.; King, Andrew D.; Mitchell, Daniel M.

2017-10-01

Record-breaking temperatures can detrimentally impact ecosystems, infrastructure, and human health. Previous studies show that climate change has influenced some observed extremes, which are expected to become more frequent under enhanced future warming. Understanding the magnitude, as a well as frequency, of such future extremes is critical for limiting detrimental impacts. We focus on temperature changes in Australian regions, including over a major coral reef-building area, and assess the potential magnitude of future extreme temperatures under Paris Agreement global warming targets (1.5°C and 2°C). Under these limits to global mean warming, we determine a set of projected high-magnitude unprecedented Australian temperature extremes. These include extremes unexpected based on observational temperatures, including current record-breaking events. For example, while the difference in global-average warming during the hottest Australian summer and the 2°C Paris target is 1.1°C, extremes of 2.4°C above the observed summer record are simulated. This example represents a more than doubling of the magnitude of extremes, compared with global mean change, and such temperatures are unexpected based on the observed record alone. Projected extremes do not necessarily scale linearly with mean global warming, and this effect demonstrates the significant potential benefits of limiting warming to 1.5°C, compared to 2°C or warmer.

Status and Future of GOES X-Ray Sensor Observations

NASA Astrophysics Data System (ADS)

Viereck, R.; Biesecker, D.

2008-05-01

The GOES X-Ray Sensor (XRS) has provided x-ray irradiance measurements in the 0.05 to 0.8 nm spectral band for nearly 30 years. These observations define the magnitude of x-ray flares. There are three issues that should be brought to the attention of the scientific community. First, today's XRS data have multiplicative factors of 0.7 and 0.85 that have been applied to the data to make recent (since GOES 8) observations match the earlier ones. We now believe that these factors are not correct and should be removed. There are implications on the magnitudes of flares and the historic record. The second issue is the current state of the XRS sensors. Two concurrent satellites, GOES 11 and GOES 12, now have failed XRS systems and the GOES 13 XRS (soon to be deployed) is only partially functioning leaving a serious vulnerability in the near future. The third issue is the future of these observations. From the beginning, the XRS detectors have been gas ionization cells which have proven to be very robust and stable. The future GOES R+ XRS instruments will be changing to solid state silicon diode detectors. The possible implications of this new detector technology should be considered as well. Details of these three issues will be presented and the implications discussed. Alternatives for the multiplicative factor and the failed XRS's will be presented.

Intensified ENSO-Driven Precipitation Teleconnections in the Future

NASA Astrophysics Data System (ADS)

Bonfils, C.; Santer, B. D.; Phillips, T. J.; Marvel, K.; Leung, L. R.; Doutriaux, C.

2014-12-01

The El Niño-Southern Oscillation (ENSO) is an important driver of regional hydroclimate variability through far-reaching teleconnections. Most climate models project an increase in the frequency of extreme El Niño events under increased greenhouse-gas (GHG) forcing. However, it is unclear how other aspects of ENSO and ENSO-driven teleconnections will evolve in the future. Here, we identify in 20th century sea-surface temperature (SST) observations a time-invariant ENSO-like (ENSOL) pattern that is largely uncontaminated by GHG forcing. We use this pattern to investigate the future precipitation (P) response to ENSO-like SST anomalies. Models that better capture observed ENSOL characteristics produce P teleconnection patterns that are in better accord with observations and more stationary in the 21st century. We decompose the future P response to ENSOL into the sum of three terms: (1) the change in P mean state, (2) the historical P response to ENSOL, and (3) a future enhancement in the P response to ENSOL. In many regions, this last term can aggravate the P extremes associated with ENSO variability. This simple decomposition allows us to identify regions likely to experience ENSOL-induced P changes that are without precedent in the current climate. This work was performed under the auspices of the U.S. Department of Energy by Lawrence Livermore National Laboratory under Contract DE-AC52-07NA27344.

Impact of space-based instruments on magnetic star research: past and future

NASA Astrophysics Data System (ADS)

Weiss, WW.; Neiner, C.; Wade, G. A.

2018-01-01

Magnetic stars are observed at a large variety of spectral ranges, frequently with photometric and spectroscopic techniques and on time scales ranging from a 'snap shot' to years, sometimes using data sets which are continuous over many months. The outcome of such observations has been discussed during this conference and many examples have been presented, demonstrating the high scientific significance and gains in our knowledge that result from these observations. A key question that should be addressed is, what are the advantages and requirements of space based research of magnetic stars, particularly in relation to ground based observations? And what are the drawbacks? What are the hopes for the future? In the following, we intend to present an overview that addresses these questions.

Several thoughts for using new satellite remote sensing and global modeling for aerosol and cloud climate studies

NASA Astrophysics Data System (ADS)

Nakajima, Teruyuki; Hashimoto, Makiko; Takenaka, Hideaki; Goto, Daisuke; Oikawa, Eiji; Suzuki, Kentaroh; Uchida, Junya; Dai, Tie; Shi, Chong

2017-04-01

The rapid growth of satellite remote sensing technologies in the last two decades widened the utility of satellite data for understanding climate impacts of aerosols and clouds. The climate modeling community also has received the benefit of the earth observation and nowadays closed-collaboration of the two communities make us possible to challenge various applications for societal problems, such as for global warming and global-scale air pollution and others. I like to give several thoughts of new algorithm developments, model use of satellite data for climate impact studies and societal applications related with aerosols and clouds. Important issues are 1) Better aerosol detection and solar energy application using expanded observation ability of the third generation geostationary satellites, i.e. Himawari-8, GOES-R and future MTG, 2) Various observation functions by directional, polarimetric, and high resolution near-UV band by MISR, POLDER&PARASOL, GOSAT/CAI and future GOSAT2/CAI2, 3) Various applications of general purpose-imagers, MODIS, VIIRS and future GCOM-C/SGLI, and 4) Climate studies of aerosol and cloud stratification and convection with active and passive sensors, especially climate impact of BC aerosols using CLOUDSAT&CALIPSO and future Earth Explorer/EarthCARE.

The Performance and Observation of Action Shape Future Behaviour

ERIC Educational Resources Information Center

Welsh, Timothy N.; McDougall, Laura M.; Weeks, Daniel J.

2009-01-01

The observation of other people's actions plays an important role in shaping the perceptual, cognitive, and motor processes of the observer. It has been suggested that these social influences occur because the observation of action evokes a representation of that response in the observer and that these codes are subsequently accessed by other…

Robust Engineering Designs for Infrastructure Adaptation to a Changing Climate

NASA Astrophysics Data System (ADS)

Samaras, C.; Cook, L.

2015-12-01

Infrastructure systems are expected to be functional, durable and safe over long service lives - 50 to over 100 years. Observations and models of climate science show that greenhouse gas emissions resulting from human activities have changed climate, weather and extreme events. Projections of future changes (albeit with uncertainties caused by inadequacies of current climate/weather models) can be made based on scenarios for future emissions, but actual future emissions are themselves uncertain. Most current engineering standards and practices for infrastructure assume that the probabilities of future extreme climate and weather events will match those of the past. Climate science shows that this assumption is invalid, but is unable, at present, to define these probabilities over the service lives of existing and new infrastructure systems. Engineering designs, plans, and institutions and regulations will need to be adaptable for a range of future conditions (conditions of climate, weather and extreme events, as well as changing societal demands for infrastructure services). For their current and future projects, engineers should: Involve all stakeholders (owners, financers, insurance, regulators, affected public, climate/weather scientists, etc.) in key decisions; Use low regret, adaptive strategies, such as robust decision making and the observational method, comply with relevant standards and regulations, and exceed their requirements where appropriate; Publish design studies and performance/failure investigations to extend the body of knowledge for advancement of practice. The engineering community should conduct observational and modeling research with climate/weather/social scientists and the concerned communities and account rationally for climate change in revised engineering standards and codes. This presentation presents initial research on decisionmaking under uncertainty for climate resilient infrastructure design.

Focus on the future

NASA Technical Reports Server (NTRS)

Hanner, Martha S.

1988-01-01

An assessment is made of what was learned from Halley and recommendations are made for future directions for infrared studies of comets and supporting lab investigations. The following issues are addressed: (1) What steps can be taken to achieve consistent interpretation of Halley infrared data; (2) How successful has the Halley Watch been for infrared studies; (3) What supporting lab research is needed; (4) What are the key infrared observations needed for future comets; and (5) How do current and future NASA programs relate to comet studies.

EOP and scale from continuous VLBI observing: CONT campaigns to future VGOS networks

NASA Astrophysics Data System (ADS)

MacMillan, D. S.

2017-07-01

Continuous (CONT) VLBI campaigns have been carried out about every 3 years since 2002. The basic idea of these campaigns is to acquire state-of-the-art VLBI data over a continuous time period of about 2 weeks to demonstrate the highest accuracy of which the current VLBI system is capable. In addition, these campaigns support scientific studies such as investigations of high-resolution Earth rotation, reference frame stability, and daily to sub-daily site motions. The size of the CONT networks and the observing data rate have increased steadily since 1994. Performance of these networks based on reference frame scale precision and polar motion/LOD comparison with global navigation satellite system (GNSS) earth orientation parameters (EOP) has been substantially better than the weekly operational R1 and R4 series. The precisions of CONT EOP and scale have improved by more than a factor of two since 2002. Polar motion precision based on the WRMS difference between VLBI and GNSS for the most recent CONT campaigns is at the 30 μas level, which is comparable to that of GNSS. The CONT campaigns are a natural precursor to the planned future VLBI observing networks, which are expected to observe continuously. We compare the performance of the most recent CONT campaigns in 2011 and 2014 with the expected performance of the future VLBI global observing system network using simulations. These simulations indicate that the expected future precision of scale and EOP will be at least 3 times better than the current CONT precision.

The UT 7/8 February 2013 Sila-Nunam Mutual Event and Future Predictions

NASA Technical Reports Server (NTRS)

Benecchi, S. D.; Noll, K. S.; Thirouin, A.; Ryan, E.; Grundy, W. M.; Verbiscer, A.; Doressoundiram, A.; Hestroffer, D.; Beaton, R.; Rabinowitz, D.;

Archiving strategy for USGS EROS center and our future direction

USGS Publications Warehouse

Faundeen, John L.

2010-01-01

The U. S. Geological Survey's Earth Resources Observation and Science Center has the responsibility to acquire, manage, and preserve our Nation's land observations. These records are obtained primarily from airplanes and satellites dating back to the 1930s. The ability to compare landscapes from the past with current information enables change analysis at local and global scales. With new observations added daily, the records management challenges are daunting, involving petabytes of electronic data and tens of thousands of rolls of analog film. This paper focuses upon the appraisal and preservation functions employed to ensure that these records are available for current and future generations.

Programmable wide field spectrograph for earth observation

NASA Astrophysics Data System (ADS)

Zamkotsian, Frédéric; Lanzoni, Patrick; Liotard, Arnaud; Viard, Thierry; Costes, Vincent; Hébert, Philippe-Jean

2017-11-01

In Earth Observation, Universe Observation and Planet Exploration, scientific return of the instruments must be optimized in future missions. Micro-Opto-Electro-Mechanical Systems (MOEMS) could be key components in future generation of space instruments. These devices are based on the mature micro-electronics technology and in addition to their compactness, scalability, and specific task customization, they could generate new functions not available with current technologies. French and European space agencies, the Centre National d'Etudes Spatiales (CNES) and the European Space Agency (ESA) have initiated several studies with LAM and TAS for listing the new functions associated with several types of MEMS, and developing new ideas of instruments.

ESA NEOCC effort to eliminate high Palermo Scale virtual impactors

NASA Astrophysics Data System (ADS)

Micheli, M.; Koschny, D.; Hainaut, O.; Bernardi, F.

2014-07-01

At the moment of this writing about 4 % of the known near-Earth objects are known to have at least one future close approach scenario with a non-negligible collision probability within the next century, as routinely computed by the NEODyS and Sentry systems. The most straightforward way to improve the knowledge of the future dynamics of an NEO in order to exclude (or possibly confirm) some of these possible future impact is to obtain additional astrometric observations of the object as soon as it becomes observable again. In particular, since a large fraction (>98 %) of the known objects currently recognized as possible future impactors have been observed during a single opposition, this usually corresponds to obtaining a new set of observations during a second opposition, a so called ''recovery''. However, in some cases the future observability windows for the target after the discovery apparition may be very limited, either because the object is intrinsically small (and therefore requires a very close and consequently rare approach to become observable) or because its orbital dynamic prevents the observability from the ground for a long timespan (as in the case of quasi-resonant objects with a long synodic period). When this happens, the only short-term way to clarify an impact scenario is to look toward the past, and investigate the possibility that unrecognized detections of the object are already present in the databases of old astronomical images, which are often archived by professional telescopes and made available to the community a few months to years after they are exposed. We will here present an effort lead by the newly formed ESA NEO Coordination Centre (NEOCC) in Frascati to pursue both these avenues with the intent of improving the orbital knowledge of the highest-rated possible impactors, as defined by the Palermo Technical Impact Hazard Scale (PS in the following). As an example of our ongoing observational activities, we will first present our recovery observations of a few very faint high-PS objects, and the follow-up observations of recently discovered objects during the outgoing phase of their apparition, down to magnitude 25 or so. Most of these observations were obtained within an accepted DDT proposal of an ESA/ESO team, which gives us access on short notice to the observational capabilities of the 8.2 meter Very Large Telescope at Cerro Paranal, Chile. The instrument has been used to successfully detect targets fainter than V=25, and provide high-accuracy astrometry which in most cases has been sufficient to remove the impact solutions from the allowed future dynamics of the object. As a main focus of our activities at the ESA NEOCC we are also actively soliciting observations of NEOs by other worldwide observers which are known to have access to the most appropriate facilities for each target (in terms of telescope aperture, camera FoV and/or geographic location). We will also quickly summarize the results of some of these activities. In the second part of this contribution, we will present the result of a focused precovery effort by our team, which led to the identification, measurement and submission of previously unrecognized archival detections of possible impactors, most of which scored particularly high in the PS ranking, but would nevertheless have been unobservable for the imminent future. We will discuss a couple of interesting cases which could be entirely excluded as a risk thanks to the addition of faint detections we located in data from the Canada- France-Hawaii Telescope (CFHT), and an interesting case of a ''chain of precoveries'' where a first short-arc precovery allowed for the identification of additional observations obtained more than a decade earlier, which in turn lead to the elimination of the impact risk from that object. We will also discuss how a real time access to the data of current surveys like Pan-STARRS can allow almost immediate precovery observations of recently discovered possible impactors, allowing to clarify the impact probability within days from the discovery, and thus saving most of the observational effort often necessary to provide adequate follow-up to recent discoveries.

Utilization of satellite imagery by in-flight aircraft. [for weather information

NASA Technical Reports Server (NTRS)

Luers, J. K.

1976-01-01

Present and future utilization of satellite weather data by commercial aircraft while in flight was assessed. Weather information of interest to aviation that is available or will become available with future geostationary satellites includes the following: severe weather areas, jet stream location, weather observation at destination airport, fog areas, and vertical temperature profiles. Utilization of this information by in-flight aircraft is especially beneficial for flights over the oceans or over remote land areas where surface-based observations and communications are sparse and inadequate.

An investigation of the role of current and future remote sensing data systems in numerical meteorology

NASA Technical Reports Server (NTRS)

Diak, George R.; Smith, William L.

1992-01-01

A flexible system for performing observing system simulation experiments which made contributions to meteorology across all elements of the observing system simulation experiment (OSSE) components was developed. Future work will seek better understanding of the links between satellite-measured radiation and radiative transfer in the clear, cloudy and precipitating atmosphere and investigate how that understanding might be applied to improve the depiction of the initial state and the treatment of physical processes in forecast models of the atmosphere.

Brief Report: Two Day-Date Processing Methods in an Autistic Savant Calendar Calculator

ERIC Educational Resources Information Center

De Marco, Matteo; Iavarone, Alessandro; Santoro, Giovanna; Carlomagno, Sergio

2016-01-01

Special ability in computing the day of week for given dates was observed in a 24 year-old male (FB) diagnosed with Asperger syndrome. FB performed almost flawlessly (98.2%) both with past and future dates, over a span of 40 years. Response latency was slower as temporal remoteness of future dates increased. Within the future timespan, FB's…

Mars 2001 Cruise Phase Radiation Measurments

NASA Technical Reports Server (NTRS)

Turner, R. E.; Badhwar, G. D.

1999-01-01

Mars 2001 presents an exciting opportunity for advances in radiation risk management of a future human mission to Mars. The mission timing is particularly fortuitous, coming just after solar maxinuun, when there will be a high probability to observe significant solar particle events (SPEs). A major objective of this mission is to characterize the Martian radiation environment to support future human missions to Mars. In addition, the MARIE instruments on the Lander and Orbiter, designed to measure the energetic particle flux at Mars, can be used during the cruise phase to provide multipoint observations of SPEs in the critical region of the heliosphere (1 to 1.5 AU) needed to reduce the in-flight radiation risk to a future Mars-bound crew.

Synthesis and Assimilation Systems - Essential Adjuncts to the Global Ocean Observing System

NASA Technical Reports Server (NTRS)

Rienecker, Michele M.; Balmaseda, Magdalena; Awaji, Toshiyuki; Barnier, Bernard; Behringer, David; Bell, Mike; Bourassa, Mark; Brasseur, Pierre; Breivik, Lars-Anders; Carton, James;

Preliminary Results From Observing The Fast Stardust Sample Return Capsule Entry In Earth's Atmosphere On January 15, 2006.

NASA Astrophysics Data System (ADS)

Jenniskens, P.; Jordan, D.; Kontinos, D.; Wright, M.; Olejniczak, J.; Raiche, G.; Wercinski, P.; Schilling, E.; Taylor, M.; Rairden, R.; Stenbaek-Nielsen, H.; McHarg, M. G.; Abe, S.; Winter, M.

2006-08-01

In order for NASA's Stardust mission to return a comet sample to Earth, the probe was put in an orbit similar to that of Near Earth Asteroids. As a result, the reentry in Earth's atmosphere on January 15, 2006, was the fastest entry ever for a NASA spacecraft, with a speed of 12.8 km/s, similar to that of natural fireballs. A new thermal protection material, PICA, was used to protect the sample, a material that may have a future as thermal protection for the Crew Return Vehicle or for future planetary missions. An airborne and ground-based observing campaign, the "Stardust Hyperseed MAC", was organized to observe the reentry under good observing conditions, with spectroscopic and imaging techniques commonly used for meteor observations (http:// reentry.arc.nasa.gov). A spectacular video of the reentry was obtained. The spectroscopic observations measure how much light was generated in the shock wave, how that radiation added to heating the surface, how the PICA ablated as a function of altitude, and how the carbon reacted with the shock wave to form CN, a possible marker of prebiotic chemistry in natural meteors. In addition, the observations measured a transient signal of zinc and potassium early in the trajectory, from the ablation of a white paint layer that had been applied to the heat shield for thermal control. Implications for sample return and the exploration of atmospheres in future planetary missions will be discussed.

Remembering the past and imagining the future: common and distinct neural substrates during event construction and elaboration

PubMed Central

Addis, Donna Rose; Wong, Alana T.; Schacter, Daniel L.

2007-01-01

People can consciously re-experience past events and pre-experience possible future events. This fMRI study examined the neural regions mediating the construction and elaboration of past and future events. Participants were cued with a noun for 20 seconds and instructed to construct a past or future event within a specified time period (week, year, 5–20 years). Once participants had the event in mind, they made a button press and for the remainder of the 20 seconds elaborated on the event. Importantly, all events generated were episodic and did not differ on a number of phenomenological qualities (detail, emotionality, personal significance, field/observer perspective). Conjunction analyses indicated the left hippocampus was commonly engaged by past and future event construction, along with posterior visuospatial regions, but considerable neural differentiation was also observed during the construction phase. Future events recruited regions involved in prospective thinking and generation processes, specifically right frontopolar cortex and left ventrolateral prefrontal cortex, respectively. Furthermore, future event construction uniquely engaged the right hippocampus, possibly as a response to the novelty of these events. In contrast to the construction phase, elaboration was characterized by remarkable overlap in regions comprising the autobiographical memory retrieval network, attributable to the common processes engaged during elaboration, including self-referential processing, contextual and episodic imagery. This striking neural overlap is consistent with findings that amnesic patients exhibit deficits in both past and future thinking, and confirms that the episodic system contributes importantly to imagining the future. PMID:17126370

Robust Bayesian Experimental Design for Conceptual Model Discrimination

NASA Astrophysics Data System (ADS)

Pham, H. V.; Tsai, F. T. C.

2015-12-01

A robust Bayesian optimal experimental design under uncertainty is presented to provide firm information for model discrimination, given the least number of pumping wells and observation wells. Firm information is the maximum information of a system can be guaranteed from an experimental design. The design is based on the Box-Hill expected entropy decrease (EED) before and after the experiment design and the Bayesian model averaging (BMA) framework. A max-min programming is introduced to choose the robust design that maximizes the minimal Box-Hill EED subject to that the highest expected posterior model probability satisfies a desired probability threshold. The EED is calculated by the Gauss-Hermite quadrature. The BMA method is used to predict future observations and to quantify future observation uncertainty arising from conceptual and parametric uncertainties in calculating EED. Monte Carlo approach is adopted to quantify the uncertainty in the posterior model probabilities. The optimal experimental design is tested by a synthetic 5-layer anisotropic confined aquifer. Nine conceptual groundwater models are constructed due to uncertain geological architecture and boundary condition. High-performance computing is used to enumerate all possible design solutions in order to identify the most plausible groundwater model. Results highlight the impacts of scedasticity in future observation data as well as uncertainty sources on potential pumping and observation locations.

Archival of Amateur Observations in Support to ESA/Rosetta Mission

NASA Astrophysics Data System (ADS)

Shirinian, R.; Yanamandra-Fisher, P. A.; Buratti, B. J.

2016-12-01

The European Space Agency's Rosetta mission to comet 67P/Churyumov-Gerasimenko (CG) has included a global ground-based observing campaign consisting of both professional and amateur observers. While professional observers have access to world class observatories with multi-spectral instruments, amateur observers use smaller aperture telescopes that mainly cover the optical spectrum. Amateur observers however, have the advantage of being able to observe as needed since their time is not competed by other observers as it is in professional facilities. This allows amateurs to create a temporal baseline of observations throughout a mission to complement professional observations with context. The Rosetta mission has had an active amateur observer campaign for over 2 years, from January 2014 to August 2016 and has nearly 150 active observers from around the globe. As the Rosetta mission and its observer campaign come to an end in September 2016, an important goal of the project is the collection and archival of the amateur observational data. The ESA's Planetary Science Archive (PSA) has created a unique system that provides firewalled user-specific directories for amateur observers to upload and archive their data, allowing professionals and amateurs to crowdsource data for future science analyses. Possible future science products could include analysis of luminosity, dust cover, position angle, and tail length, all of which can be analyzed over time due to the consistent amateur data taken for over two years. A challenge for the project is that amateur observers have varying amounts of data, ranging from a few megabytes to several gigabytes. Our project addresses the retrieval of amateur observations, renaming, reformatting, and upload to the PSA. The final steps of the archival of amateur observations are the quality check of the data, some of the possible analyses, and identification of data that can be integrated with professional data analysis. The unique integration of amateur observations and professional observations will be crowdsourced for future scientific analysis. This research project was conducted at NASA/JPL/Caltech with funding from NASA and the NSF REU site Consortium for Undergraduate Research Experiences (CURE) ran through LACC.

Observations, theoretical ideas and modeling of turbulent flows: Past, present and future

NASA Technical Reports Server (NTRS)

Chapman, G. T.; Tobak, M.

1985-01-01

Turbulence was analyzed in a historical context featuring the interactions between observations, theoretical ideas, and modeling within three successive movements. These are identified as predominantly statistical, structural and deterministic. The statistical movement is criticized for its failure to deal with the structural elements observed in turbulent flows. The structural movement is criticized for its failure to embody observed structural elements within a formal theory. The deterministic movement is described as having the potential of overcoming these deficiencies by allowing structural elements to exhibit chaotic behavior that is nevertheless embodied within a theory. Four major ideas of this movement are described: bifurcation theory, strange attractors, fractals, and the renormalization group. A framework for the future study of turbulent flows is proposed, based on the premises of the deterministic movement.

A perspective about the total solar eclipse observation from future space settlements and a review of Indonesian space researches

NASA Astrophysics Data System (ADS)

Sastradipradja, D.; Dwivany, F. M.; Swandjaja, L.

2016-11-01

Viewing astronomy objects from space is superior to that from Earth due to the absence of terrestrial atmospheric disturbances. Since decades ago, there has been an idea of building gigantic spaceships to live in, i.e., low earth orbit (LEO) settlement. In the context of solar eclipse, the presuming space settlements will accommodate future solar eclipse chasers (amateur or professional astronomers) to observe solar eclipse from space. Not only for scientific purpose, human personal observation from space is also needed for getting aesthetical mental impression. Furthermore, since space science indirectly aids solar eclipse observation, we will discuss the related history and development of Indonesian space experiments. Space science is an essential knowledge to be mastered by all nations.

The origin of the diffuse background gamma-radiation

NASA Technical Reports Server (NTRS)

Stecker, F. W.; Puget, J. L.

1974-01-01

Recent observations have now provided evidence for diffuse background gamma radiation extending to energies beyond 100 MeV. There is some evidence of isotropy and implied cosmological origin. Significant features in the spectrum of this background radiation have been observed which provide evidence for its origin in nuclear processes in the early stages of the big-band cosmology and tie in these processes with galaxy fromation theory. A crucial test of the theory may lie in future observations of the background radiation in the 100 MeV to 100 GeV energy range which may be made with large orbiting spark-chamber satellite detectors. A discussion of the theoretical interpretations of present data, their connection with baryon symmetric cosmology and galaxy formation theory, and the need for future observations are given.

The operating room of the future: observations and commentary.

PubMed

Satava, Richard M

2003-09-01

The Operating Room of the Future is a construct upon which to develop the next generation of operating environments for the patient, surgeon, and operating team. Analysis of the suite of visions for the Operating Room of the Future reveals a broad set of goals, with a clear overall solution to create a safe environment for high-quality healthcare. The vision, although planned for the future, is based upon iteratively improving and integrating current systems, both technology and process. This must become the Operating Room of Today, which will require the enormous efforts described. An alternative future of the operating room, based upon emergence of disruptive technologies, is also presented.

Observational needs for estimating Alaskan soil carbon stocks under current and future climate

DOE PAGES

Vitharana, U. W. A.; Mishra, U.; Jastrow, J. D.; ...

2017-01-24

Representing land surface spatial heterogeneity when designing observation networks is a critical scientific challenge. Here we present a geospatial approach that utilizes the multivariate spatial heterogeneity of soil-forming factors—namely, climate, topography, land cover types, and surficial geology—to identify observation sites to improve soil organic carbon (SOC) stock estimates across the State of Alaska, USA. Standard deviations in existing SOC samples indicated that 657, 870, and 906 randomly distributed pedons would be required to quantify the average SOC stocks for 0–1 m, 0–2 m, and whole-profile depths, respectively, at a confidence interval of 5 kg C m -2. Using the spatialmore » correlation range of existing SOC samples, we identified that 309, 446, and 484 new observation sites are needed to estimate current SOC stocks to 1 m, 2 m, and whole-profile depths, respectively. We also investigated whether the identified sites might change under future climate by using eight decadal (2020–2099) projections of precipitation, temperature, and length of growing season for three representative concentration pathway (RCP 4.5, 6.0, and 8.5) scenarios of the Intergovernmental Panel on Climate Change. These analyses determined that 12 to 41 additional sites (906 + 12 to 41; depending upon the emission scenarios) would be needed to capture the impact of future climate on Alaskan whole-profile SOC stocks by 2100. The identified observation sites represent spatially distributed locations across Alaska that captures the multivariate heterogeneity of soil-forming factors under current and future climatic conditions. This information is needed for designing monitoring networks and benchmarking of Earth system model results.« less

Observational needs for estimating Alaskan soil carbon stocks under current and future climate

DOE Office of Scientific and Technical Information (OSTI.GOV)

Vitharana, U. W. A.; Mishra, U.; Jastrow, J. D.

Representing land surface spatial heterogeneity when designing observation networks is a critical scientific challenge. Here we present a geospatial approach that utilizes the multivariate spatial heterogeneity of soil-forming factors—namely, climate, topography, land cover types, and surficial geology—to identify observation sites to improve soil organic carbon (SOC) stock estimates across the State of Alaska, USA. Standard deviations in existing SOC samples indicated that 657, 870, and 906 randomly distributed pedons would be required to quantify the average SOC stocks for 0–1 m, 0–2 m, and whole-profile depths, respectively, at a confidence interval of 5 kg C m -2. Using the spatialmore » correlation range of existing SOC samples, we identified that 309, 446, and 484 new observation sites are needed to estimate current SOC stocks to 1 m, 2 m, and whole-profile depths, respectively. We also investigated whether the identified sites might change under future climate by using eight decadal (2020–2099) projections of precipitation, temperature, and length of growing season for three representative concentration pathway (RCP 4.5, 6.0, and 8.5) scenarios of the Intergovernmental Panel on Climate Change. These analyses determined that 12 to 41 additional sites (906 + 12 to 41; depending upon the emission scenarios) would be needed to capture the impact of future climate on Alaskan whole-profile SOC stocks by 2100. The identified observation sites represent spatially distributed locations across Alaska that captures the multivariate heterogeneity of soil-forming factors under current and future climatic conditions. This information is needed for designing monitoring networks and benchmarking of Earth system model results.« less

Comparison of Recent Modeled and Observed Trends in Total Column Ozone

NASA Technical Reports Server (NTRS)

Andersen, S. B.; Weatherhead, E. C.; Stevermer, A.; Austin, J.; Bruehl, C.; Fleming, E. L.; deGrandpre, J.; Grewe, V.; Isaksen, I.; Pitari, G.;

Comparison of recent modeled and observed trends in total column ozone

NASA Astrophysics Data System (ADS)

Andersen, S. B.; Weatherhead, E. C.; Stevermer, A.; Austin, J.; Brühl, C.; Fleming, E. L.; de Grandpré, J.; Grewe, V.; Isaksen, I.; Pitari, G.; Portmann, R. W.; Rognerud, B.; Rosenfield, J. E.; Smyshlyaev, S.; Nagashima, T.; Velders, G. J. M.; Weisenstein, D. K.; Xia, J.

2006-01-01

We present a comparison of trends in total column ozone from 10 two-dimensional and 4 three-dimensional models and solar backscatter ultraviolet-2 (SBUV/2) satellite observations from the period 1979-2003. Trends for the past (1979-2000), the recent 7 years (1996-2003), and the future (2000-2050) are compared. We have analyzed the data using both simple linear trends and linear trends derived with a hockey stick method including a turnaround point in 1996. If the last 7 years, 1996-2003, are analyzed in isolation, the SBUV/2 observations show no increase in ozone, and most of the models predict continued depletion, although at a lesser rate. In sharp contrast to this, the recent data show positive trends for the Northern and the Southern Hemispheres if the hockey stick method with a turnaround point in 1996 is employed for the models and observations. The analysis shows that the observed positive trends in both hemispheres in the recent 7-year period are much larger than what is predicted by the models. The trends derived with the hockey stick method are very dependent on the values just before the turnaround point. The analysis of the recent data therefore depends greatly on these years being representative of the overall trend. Most models underestimate the past trends at middle and high latitudes. This is particularly pronounced in the Northern Hemisphere. Quantitatively, there is much disagreement among the models concerning future trends. However, the models agree that future trends are expected to be positive and less than half the magnitude of the past downward trends. Examination of the model projections shows that there is virtually no correlation between the past and future trends from the individual models.

Supraspinal and spinal effects of L-trans-PDC, an inhibitor of glutamate transporter, on the micturition reflex in rats.

PubMed

Honda, Masashi; Yoshimura, Naoki; Hikita, Katsuya; Hinata, Nobuyuki; Muraoka, Kuniyasu; Saito, Motoaki; Chancellor, Michael B; Takenaka, Atsushi

2013-09-01

Glutamate is a major excitatory transmitter in the central nervous system, controlling lower urinary tract function. Five types of glutamate transporters such as GLAST (EAAT1), GLT-1 (EAAT2), EAAC-1 (EAAT3), EAAT4, and EAAT5 have been cloned so far. In the current study we tested whether L-trans-pyrrolidine-2,4-dicarboxylic acid (L-trans-PDC), a non-selective inhibitor of glutamate transporters that increases endogenous glutamate concentration, can affect the micturition reflex in urethane anesthetized rats. Continuous cystometrograms (CMG, 0.04 ml/min infusion rate) were performed in two groups of urethane-anesthetized rats. A group of 18 rats was used for intrathecal administration of 1-10 µg of L-trans-PDC via an intrathecal catheter. In the second group of 18 rats, 1-10 µg of L-trans-PDC were administered intracerebroventricularly via a catheter inserted into the lateral ventricle. Micturition parameters were recorded and compared before and after drug administration. Intrathecal administration of L-trans-PDC at 1, 3, and 10 µg (n = 6 per dose) increased intercontraction intervals in dose dependent fashion, but did not affect postvoid residual or basal pressure at any doses tested. Intracerebroventricular administration of L-trans-PDC at 1, 3, and 10 µg (n = 6 per dose) also increased intercontraction intervals in dose dependent fashion, but did not affect postvoid residual or basal pressure at any doses tested. The current results show that, in urethane-anesthetized rats, suppression of glutamate transporters by L-trans-PDC has an inhibitory effect on the micturition reflex at supraspinal and spinal sites, possibly via activation of glutamate-mediated inhibitory pathways. Copyright © 2012 Wiley Periodicals, Inc.

Effects of repeated cocaine exposure and withdrawal on voluntary ethanol drinking, and the expression of glial glutamate transporters in mesocorticolimbic system of P rats.

PubMed

Hammad, Alaa M; Althobaiti, Yusuf S; Das, Sujan C; Sari, Youssef

2017-07-01

Glutamatergic neurotransmission within the brain's reward circuits plays a major role in the reinforcing properties of both ethanol and cocaine. Glutamate homeostasis is regulated by several glutamate transporters, including glutamate transporter type 1 (GLT-1), cystine/glutamate transporter (xCT), and glutamate aspartate transporter (GLAST). Cocaine exposure has been shown to induce a dysregulation in glutamate homeostasis and a decrease in the expression of GLT-1 and xCT in the nucleus accumbens (NAc). In this study, alcohol preferring (P) rats were exposed to free-choice of ethanol (15% and 30%) and/or water for five weeks. On Week 6, rats were administered (i.p.) cocaine (10 and 20mg/kg) or saline for 12 consecutive days. This study tested two groups of rats: the first group was euthanized after seven days of repeated cocaine i.p. injection, and the second group was deprived from cocaine for five days and euthanized at Day 5 after cocaine withdrawal. Only repeated cocaine (20mg/kg, i.p.) exposure decreased ethanol intake from Day 3 through Day 8. Co-exposure of cocaine and ethanol decreased the relative mRNA expression and the expression of GLT-1 in the NAc but not in the medial prefrontal cortex (mPFC). Importantly, co-exposure of cocaine and ethanol decreased relative expression of xCT in the NAc but not in the mPFC. Our findings demonstrated that chronic cocaine exposure affects ethanol intake; and ethanol and cocaine co-abuse alters the expression of glial glutamate transporters. Copyright © 2017 Elsevier Inc. All rights reserved.

Pluripotent stem cell-derived radial glia-like cells as stable intermediate for efficient generation of human oligodendrocytes.

PubMed

Gorris, Raphaela; Fischer, Julia; Erwes, Kim Lina; Kesavan, Jaideep; Peterson, Daniel A; Alexander, Michael; Nöthen, Markus M; Peitz, Michael; Quandel, Tamara; Karus, Michael; Brüstle, Oliver

2015-12-01

Neural precursor cells (NPCs) derived from human pluripotent stem cells (hPSCs) represent an attractive tool for the in vitro generation of various neural cell types. However, the developmentally early NPCs emerging during hPSC differentiation typically show a strong propensity for neuronal differentiation, with more limited potential for generating astrocytes and, in particular, for generating oligodendrocytes. This phenomenon corresponds well to the consecutive and protracted generation of neurons and GLIA during normal human development. To obtain a more gliogenic NPC type, we combined growth factor-mediated expansion with pre-exposure to the differentiation-inducing agent retinoic acid and subsequent immunoisolation of CD133-positive cells. This protocol yields an adherent and self-renewing population of hindbrain/spinal cord radial glia (RG)-like neural precursor cells (RGL-NPCs) expressing typical neural stem cell markers such as nestin, ASCL1, SOX2, and PAX6 as well as RG markers BLBP, GLAST, vimentin, and GFAP. While RGL-NPCs maintain the ability for tripotential differentiation into neurons, astrocytes, and oligodendrocytes, they exhibit greatly enhanced propensity for oligodendrocyte generation. Under defined differentiation conditions promoting the expression of the major oligodendrocyte fate-determinants OLIG1/2, NKX6.2, NKX2.2, and SOX10, RGL-NPCs efficiently convert into NG2-positive oligodendroglial progenitor cells (OPCs) and are subsequently capable of in vivo myelination. Representing a stable intermediate between PSCs and OPCs, RGL-NPCs expedite the generation of PSC-derived oligodendrocytes with O4-, 4860-, and myelin basic protein (MBP)-positive cells that already appear within 7 weeks following growth factor withdrawal-induced differentiation. Thus, RGL-NPCs may serve as robust tool for time-efficient generation of human oligodendrocytes from embryonic and induced pluripotent stem cells. © 2015 Wiley Periodicals, Inc.

HMG-CoA synthase isoenzymes 1 and 2 localize to satellite glial cells in dorsal root ganglia and are differentially regulated by peripheral nerve injury.

PubMed

Wang, Fei; Xiang, Hongfei; Fischer, Gregory; Liu, Zhen; Dupont, Matthew J; Hogan, Quinn H; Yu, Hongwei

2016-12-01

In dorsal root ganglia (DRG), satellite glial cells (SGCs) tightly ensheathe the somata of primary sensory neurons to form functional sensory units. SGCs are identified by their flattened and irregular morphology and expression of a variety of specific marker proteins. In this report, we present evidence that the 3-hydroxy-3-methylglutaryl coenzyme A synthase isoenzymes 1 and 2 (HMGCS1 and HMGCS2) are abundantly expressed in SGCs. Immunolabeling with the validated antibodies revealed that both HMGCS1 and HMGCS2 are highly colabeled with a selection of SGC markers, including GS, GFAP, K ir 4.1, GLAST1, GDNF, and S100 but not with microglial cell marker Iba1, myelin sheath marker MBP, and neuronal marker β3-tubulin or phosphorylated CaMKII. HMGCS1 but not HMGCS2 immunoreactivity in SGCs is reduced in the fifth lumbar (L5) DRGs that contain axotomized neurons following L5 spinal nerve ligation (SNL) in rats. Western blot showed that HMGCS1 protein level in axotomized L5 DRGs is reduced after SNL to 66±8% at 3 days (p<0.01, n=4 animals in each group) and 58±13% at 28 days (p<0.001, n=9 animals in each group) of its level in control samples, whereas HMGCS2 protein was comparable between injured and control DRGs. These results identify HMGCSs as the alternative markers for SGCs in DRGs. Downregulated HMGCS1 expression in DRGs after spinal nerve injury may reflect a potential role of abnormal sterol metabolism of SGCs in the nerve injured-induced neuropathic pain. Copyright © 2016 Elsevier B.V. All rights reserved.

Fermi discovers giant gamma-ray bubbles in the Milky Way

NASA Image and Video Library

2017-12-08

NASA image release November 9, 2010 To view a video about this story go to: www.flickr.com/photos/gsfc/5162413062 Using data from NASA's Fermi Gamma-ray Space Telescope, scientists have recently discovered a gigantic, mysterious structure in our galaxy. This never-before-seen feature looks like a pair of bubbles extending above and below our galaxy's center. But these enormous gamma-ray emitting lobes aren't immediately visible in the Fermi all-sky map. However, by processing the data, a group of scientists was able to bring these unexpected structures into sharp relief. Each lobe is 25,000 light-years tall and the whole structure may be only a few million years old. Within the bubbles, extremely energetic electrons are interacting with lower-energy light to create gamma rays, but right now, no one knows the source of these electrons. Are the bubbles remnants of a massive burst of star formation? Leftovers from an eruption by the supermassive black hole at our galaxy's center? Or or did these forces work in tandem to produce them? Scientists aren't sure yet, but the more they learn about this amazing structure, the better we'll understand the Milky Way. To learn more go to: www.nasa.gov/mission_pages/GLAST/news/new-structure.html NASA Goddard Space Flight Center enables NASA’s mission through four scientific endeavors: Earth Science, Heliophysics, Solar System Exploration, and Astrophysics. Goddard plays a leading role in NASA’s accomplishments by contributing compelling scientific knowledge to advance the Agency’s mission. Follow us on Twitter Join us on Facebook Credit: NASA/Goddard Space Flight Center Scientific Visualization Studio

Discovery of Pulsations from the Pulsar J0205 6449 in SNR 3C 58 with the Fermi Gamma-Ray Space Telescope

DOE Office of Scientific and Technical Information (OSTI.GOV)

Abdo, Aous A.; /Naval Research Lab, Wash., D.C.; Ackermann, M.

2011-12-01

We report the discovery of {gamma}-ray pulsations ({ge}0.1 GeV) from the young radio and X-ray pulsar PSR J0205 + 6449 located in the Galactic supernova remnant 3C 58. Data in the {gamma}-ray band were acquired by the Large Area Telescope aboard the Fermi Gamma-ray Space Telescope (formerly GLAST), while the radio rotational ephemeris used to fold {gamma}-rays was obtained using both the Green Bank Telescope and the Lovell telescope at Jodrell Bank. The light curve consists of two peaks separated by 0.49 {+-} 0.01 {+-} 0.01 cycles which are aligned with the X-ray peaks. The first {gamma}-ray peak trails themore » radio pulse by 0.08 {+-} 0.01 {+-} 0.01, while its amplitude decreases with increasing energy as for the other {gamma}-ray pulsars. Spectral analysis of the pulsed {gamma}-ray emission suggests a simple power law of index -2.1 {+-} 0.1 {+-} 0.2 with an exponential cutoff at 3.0{sub -0.7}{sup +1.1} {+-} 0.4 GeV. The first uncertainty is statistical and the second is systematic. The integral {gamma}-ray photon flux above 0.1 GeV is (13.7 {+-} 1.4 {+-} 3.0) x 10{sup -8} cm{sup -2} s{sup -1}, which implies for a distance of 3.2 kpc and assuming a broad fan-like beam a luminosity of 8.3 x 10{sup 34} erg s{sup -1} and an efficiency {eta} of 0.3%. Finally, we report a 95% upper limit on the flux of 1.7 x 10{sup -8} cm{sup -2} s{sup -1} for off-pulse emission from the object.« less

DISCOVERY OF PULSATIONS FROM THE PULSAR J0205+6449 IN SNR 3C 58 WITH THE FERMI GAMMA-RAY SPACE TELESCOPE

DOE Office of Scientific and Technical Information (OSTI.GOV)

Abdo, A. A.; Ackermann, M.; Ajello, M.

2009-07-10

We report the discovery of {gamma}-ray pulsations ({>=}0.1 GeV) from the young radio and X-ray pulsar PSR J0205 + 6449 located in the Galactic supernova remnant 3C 58. Data in the {gamma}-ray band were acquired by the Large Area Telescope aboard the Fermi Gamma-ray Space Telescope (formerly GLAST), while the radio rotational ephemeris used to fold {gamma}-rays was obtained using both the Green Bank Telescope and the Lovell telescope at Jodrell Bank. The light curve consists of two peaks separated by 0.49 {+-} 0.01 {+-} 0.01 cycles which are aligned with the X-ray peaks. The first {gamma}-ray peak trails themore » radio pulse by 0.08 {+-} 0.01 {+-} 0.01, while its amplitude decreases with increasing energy as for the other {gamma}-ray pulsars. Spectral analysis of the pulsed {gamma}-ray emission suggests a simple power law of index -2.1 {+-} 0.1 {+-} 0.2 with an exponential cutoff at 3.0{sup +1.1} {sub -0.7} {+-} 0.4 GeV. The first uncertainty is statistical and the second is systematic. The integral {gamma}-ray photon flux above 0.1 GeV is (13.7 {+-} 1.4 {+-} 3.0) x 10{sup -8} cm{sup -2} s{sup -1}, which implies for a distance of 3.2 kpc and assuming a broad fan-like beam a luminosity of 8.3 x 10{sup 34} erg s{sup -1} and an efficiency {eta} of 0.3%. Finally, we report a 95% upper limit on the flux of 1.7 x 10{sup -8} cm{sup -2} s{sup -1} for off-pulse emission from the object.« less

Glutamate transporter-associated anion channels adjust intracellular chloride concentrations during glial maturation.

PubMed

Untiet, Verena; Kovermann, Peter; Gerkau, Niklas J; Gensch, Thomas; Rose, Christine R; Fahlke, Christoph

2017-02-01

Astrocytic volume regulation and neurotransmitter uptake are critically dependent on the intracellular anion concentration, but little is known about the mechanisms controlling internal anion homeostasis in these cells. Here we used fluorescence lifetime imaging microscopy (FLIM) with the chloride-sensitive dye MQAE to measure intracellular chloride concentrations in murine Bergmann glial cells in acute cerebellar slices. We found Bergmann glial [Cl - ] int to be controlled by two opposing transport processes: chloride is actively accumulated by the Na + -K + -2Cl - cotransporter NKCC1, and chloride efflux through anion channels associated with excitatory amino acid transporters (EAATs) reduces [Cl - ] int to values that vary upon changes in expression levels or activity of these channels. EAATs transiently form anion-selective channels during glutamate transport, and thus represent a class of ligand-gated anion channels. Age-dependent upregulation of EAATs results in a developmental chloride switch from high internal chloride concentrations (51.6 ± 2.2 mM, mean ± 95% confidence interval) during early development to adult levels (35.3 ± 0.3 mM). Simultaneous blockade of EAAT1/GLAST and EAAT2/GLT-1 increased [Cl - ] int in adult glia to neonatal values. Moreover, EAAT activation by synaptic stimulations rapidly decreased [Cl - ] int . Other tested chloride channels or chloride transporters do not contribute to [Cl - ] int under our experimental conditions. Neither genetic removal of ClC-2 nor pharmacological block of K + -Cl - cotransporter change resting Bergmann glial [Cl - ] int in acute cerebellar slices. We conclude that EAAT anion channels play an important and unexpected role in adjusting glial intracellular anion concentration during maturation and in response to cerebellar activity. GLIA 2017;65:388-400. © 2016 Wiley Periodicals, Inc.

HIGH-ENERGY EMISSION OF GRB 130427A: EVIDENCE FOR INVERSE COMPTON RADIATION

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fan, Yi-Zhong; Zhang, Fu-Wen; He, Hao-Ning

2013-10-20

A nearby superluminous burst GRB 130427A was simultaneously detected by six γ-ray space telescopes (Swift, the Fermi GLAST Burst Monitor (GBM)/Large Area Telescope, Konus-Wind, SPI-ACS/INTEGRAL, AGILE, and RHESSI) and by three RAPTOR full-sky persistent monitors. The isotropic γ-ray energy release is ∼10{sup 54} erg, rendering it the most powerful explosion among gamma-ray bursts (GRBs) with a redshift z ≤ 0.5. The emission above 100 MeV lasted about one day, and four photons are at energies greater than 40 GeV. We show that the count rate of 100 MeV-100 GeV emission may be mainly accounted for by the forward shock synchrotronmore » radiation and the inverse Compton radiation likely dominates at GeV-TeV energies. In particular, an inverse Compton radiation origin is favored for the ∼(95.3, 47.3, 41.4, 38.5, 32) GeV photons arriving at t ∼ (243, 256.3, 610.6, 3409.8, 34366.2) s after the trigger of Fermi-GBM. Interestingly, the external inverse Compton scattering of the prompt emission (the second episode, i.e., t ∼ 120-260 s) by the forward-shock-accelerated electrons is expected to produce a few γ-rays at energies above 10 GeV, while five were detected in the same time interval. A possible unified model for the prompt soft γ-ray, optical, and GeV emission of GRB 130427A, GRB 080319B, and GRB 090902B is outlined. Implications of the null detection of >1 TeV neutrinos from GRB 130427A by IceCube are discussed.« less

The Selective Glucocorticoid Receptor Modulator Cort 113176 Reduces Neurodegeneration and Neuroinflammation in Wobbler Mice Spinal Cord.

PubMed

Meyer, Maria; Lara, Agustina; Hunt, Hazel; Belanoff, Joseph; de Kloet, E Ronald; Gonzalez Deniselle, Maria Claudia; De Nicola, Alejandro F

2018-06-08

Wobbler mice are experimental models for amyotrophic lateral sclerosis. As such they show motoneuron degeneration, motor deficits, and astrogliosis and microgliosis of the spinal cord. Additionally, Wobbler mice show increased plasma, spinal cord and brain corticosterone levels and focal adrenocortical hyperplasia, suggesting a pathogenic role for glucocorticoids in this disorder. Considering this endocrine background, we examined whether the glucocorticoid receptor (GR) modulator CORT 113176 prevents spinal cord neuropathology of Wobblers. CORT 113176 shows high affinity for the GR, with low or null affinity for other steroid receptors. We employed five-month-old genotyped Wobbler mice that received s.c. vehicle or 30 mg/kg/day for 4 days of CORT 113176 dissolved in sesame oil. The mice were used on the 4th day, 2 h after the last dose of CORT 113176. Vehicle-treated Wobbler mice presented vacuolated motoneurons, increased glial fibrillary acidic protein (GFAP)+ astrocytes and decreased glutamine synthase (GS)+ cells. There was strong neuroinflammation, shown by increased staining for IBA1+ microglia and CD11b mRNA, enhanced expression of tumor necrosis factor-α, its cognate receptor TNFR1, toll-like receptor 4, the inducible nitric oxide synthase, NFkB and the high-mobility group box 1 protein (HMGB1). Treatment of Wobbler mice with CORT 113176 reversed the abnormalities of motoneurons and down-regulated proinflammatory mediators and glial reactivity. Expression of glutamate transporters GLT1 and GLAST mRNAs and GLT1 protein was significantly enhanced over untreated Wobblers. In summary, antagonism of GR with CORT 113176 prevented neuropathology and showed anti-inflammatory and anti-glutamatergic effects in the spinal cord of Wobbler mice. Copyright © 2018 IBRO. Published by Elsevier Ltd. All rights reserved.

Human T-cell lymphotropic virus type 1-infected T lymphocytes impair catabolism and uptake of glutamate by astrocytes via Tax-1 and tumor necrosis factor alpha.

PubMed

Szymocha, R; Akaoka, H; Dutuit, M; Malcus, C; Didier-Bazes, M; Belin, M F; Giraudon, P

2000-07-01

Human T-cell lymphotropic virus type 1 (HTLV-1) is the causative agent of a chronic progressive myelopathy called tropical spastic paraparesis/HTLV-1-associated myelopathy (TSP/HAM). In this disease, lesions of the central nervous system (CNS) are associated with perivascular infiltration by lymphocytes. We and others have hypothesized that these T lymphocytes infiltrating the CNS may play a prominent role in TSP/HAM. Here, we show that transient contact of human or rat astrocytes with T lymphocytes chronically infected by HTLV-1 impairs some of the major functions of brain astrocytes. Uptake of extracellular glutamate by astrocytes was significantly decreased after transient contact with infected T cells, while the expression of the glial transporters GLAST and GLT-1 was decreased. In two-compartment cultures avoiding direct cell-to-cell contact, similar results were obtained, suggesting possible involvement of soluble factors, such as cytokines and the viral protein Tax-1. Recombinant Tax-1 and tumor necrosis factor alpha (TNF-alpha) decreased glutamate uptake by astrocytes. Tax-1 probably acts by inducing TNF-alpha, as the effect of Tax-1 was abolished by anti-TNF-alpha antibody. The expression of glutamate-catabolizing enzymes in astrocytes was increased for glutamine synthetase and decreased for glutamate dehydrogenase, the magnitudes of these effects being correlated with the level of Tax-1 transcripts. In conclusion, Tax-1 and cytokines produced by HTLV-1-infected T cells impair the ability of astrocytes to manage the steady-state level of glutamate, which in turn may affect neuronal and oligodendrocytic functions and survival.

Grewia tiliaefolia and its active compound vitexin regulate the expression of glutamate transporters and protect Neuro2a cells from glutamate toxicity.

PubMed

Malar, Dicson Sheeja; Prasanth, Mani Iyer; Shafreen, Rajamohamed Beema; Balamurugan, Krishnaswamy; Devi, Kasi Pandima

2018-04-25

Glutamate is a major neurotransmitter involved in several brain functions and glutamate excitotoxicity is involved in Alzheimer's disease (AD). In the current study, the neuroprotective effect of the Indian medicinal plant Grewia tiliaefolia (GT) and its active component vitexin was evaluated in Neuro-2a cells against glutamate toxicity. Neuro-2a cells were exposed to glutamate to cause excitotoxicity and the neuroprotective effect of GT and vitexin were evaluated using biochemical studies (estimation of reactive oxygen species, reactive nitrogen species, protein carbonyl content, lipid peroxidation level, mitochondrial membrane potential and caspase-3 activity), molecular docking studies, gene expression and western blot analysis. Glutamate exposure to Neuro-2a cells induced oxidative stress, loss of membrane potential, suppressed the expression of antioxidant response genes (Nrf-2, HO-1, NQO-1), glutamate transporters (GLAST-1, GLT-1) and induced the expression of NMDAR, Calpain. However, pre-treatment of cells with GT/vitexin inhibited oxidative stress mediated damage by augmenting the expression of Nrf-2/HO-1 pathway, inducing the expression of glutamate transporters and downregulating Calpain, NMDAR. Molecular docking showed that vitexin effectively binds to NMDAR and GSK-3β and thereby can inhibit their activation. GT/vitexin also inhibited glutamate induced Bax expression. Methanol extract of G. tiliaefolia and its active component vitexin can act in an antioxidant dependent mechanism as well as by regulating glutamate in mitigating the toxicity exerted by glutamate in Neuro-2a cells. Our results conclude that GT/vitexin can act as potential drug leads for the therapeutic intervention of AD. Copyright © 2017. Published by Elsevier Inc.

GLAST Burst Monitor Signal Processing System

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bhat, P. Narayana; Briggs, Michael; Connaughton, Valerie

The onboard Data Processing Unit (DPU), designed and built by Southwest Research Institute, performs the high-speed data acquisition for GBM. The analog signals from each of the 14 detectors are digitized by high-speed multichannel analog data acquisition architecture. The streaming digital values resulting from a periodic (period of 104.2 ns) sampling of the analog signal by the individual ADCs are fed to a Field-Programmable Gate Array (FPGA). Real-time Digital Signal Processing (DSP) algorithms within the FPGA implement functions like filtering, thresholding, time delay and pulse height measurement. The spectral data with a 12-bit resolution are formatted according to the commandablemore » look-up-table (LUT) and then sent to the High-Speed Science-Date Bus (HSSDB, speed=1.5 MB/s) to be telemetered to ground. The DSP offers a novel feature of a commandable and constant event deadtime. The ADC non-linearities have been calibrated so that the spectral data can be corrected during analysis. The best temporal resolution is 2 {mu}s for the pre-burst and post-trigger time-tagged events (TTE) data. The time resolution of the binned data types is commandable from 64 msec to 1.024 s for the CTIME data (8 channel spectral resolution) and 1.024 to 32.768 s for the CSPEC data (128 channel spectral resolution). The pulse pile-up effects have been studied by Monte Carlo simulations. For a typical GRB, the possible shift in the Epeak value at high-count rates ({approx}100 kHz) is {approx}1% while the change in the single power-law index could be up to 5%.« less

Effects of acute hypoxia/acidosis on intracellular pH in differentiating neural progenitor cells.

PubMed

Nordström, Tommy; Jansson, Linda C; Louhivuori, Lauri M; Akerman, Karl E O

2012-06-21

The response of differentiating mouse neural progenitor cells, migrating out from neurospheres, to conditions simulating ischemia (hypoxia and extracellular or intracellular acidosis) was studied. We show here, by using BCECF and single cell imaging to monitor intracellular pH (pH(i)), that two main populations can be distinguished by exposing migrating neural progenitor cells to low extracellular pH or by performing an acidifying ammonium prepulse. The cells dominating at the periphery of the neurosphere culture, which were positive for neuron specific markers MAP-2, calbindin and NeuN had lower initial resting pH(i) and could also easily be further acidified by lowering the extracellular pH. Moreover, in this population, a more profound acidification was seen when the cells were acidified using the ammonium prepulse technique. However, when the cell population was exposed to depolarizing potassium concentrations no alterations in pH(i) took place in this population. In contrast, depolarization caused an increase in pH(i) (by 0.5 pH units) in the cell population closer to the neurosphere body, which region was positive for the radial cell marker (GLAST). This cell population, having higher resting pH(i) (pH 6.9-7.1) also responded to acute hypoxia. During hypoxic treatment the resting pH(i) decreased by 0.1 pH units and recovered rapidly after reoxygenation. Our results show that migrating neural progenitor cells are highly sensitive to extracellular acidosis and that irreversible damage becomes evident at pH 6.2. Moreover, our results show that a response to acidosis clearly distinguishes two individual cell populations probably representing neuronal and radial cells. Copyright © 2012 Elsevier B.V. All rights reserved.

Neuroprotective Effects of the Glutamate Transporter Activator (R)-(−)-5-methyl-1-nicotinoyl-2-pyrazoline (MS-153) following Traumatic Brain Injury in the Adult Rat

PubMed Central

Fox, Douglas P.; Zoubroulis, Argie; Valente Mortensen, Ole; Raghupathi, Ramesh

2016-01-01

Abstract Traumatic brain injury (TBI) in humans and in animals leads to an acute and sustained increase in tissue glutamate concentrations within the brain, triggering glutamate-mediated excitotoxicity. Excitatory amino acid transporters (EAATs) are responsible for maintaining extracellular central nervous system glutamate concentrations below neurotoxic levels. Our results demonstrate that as early as 5 min and up to 2 h following brain trauma in brain-injured rats, the activity (Vmax) of EAAT2 in the cortex and the hippocampus was significantly decreased, compared with sham-injured animals. The affinity for glutamate (KM) and the expression of glutamate transporter 1 (GLT-1) and glutamate aspartate transporter (GLAST) were not altered by the injury. Administration of (R)-(−)-5-methyl-1-nicotinoyl-2-pyrazoline (MS-153), a GLT-1 activator, beginning immediately after injury and continuing for 24 h, significantly decreased neurodegeneration, loss of microtubule-associated protein 2 and NeuN (+) immunoreactivities, and attenuated calpain activation in both the cortex and the hippocampus at 24 h after the injury; the reduction in neurodegeneration remained evident up to 14 days post-injury. In synaptosomal uptake assays, MS-153 up-regulated GLT-1 activity in the naïve rat brain but did not reverse the reduced activity of GLT-1 in traumatically-injured brains. This study demonstrates that administration of MS-153 in the acute post-traumatic period provides acute and long-term neuroprotection for TBI and suggests that the neuroprotective effects of MS-153 are related to mechanisms other than GLT-1 activation, such as the inhibition of voltage-gated calcium channels. PMID:26200170

Iowa observation well network; past, present, and future

USGS Publications Warehouse

Logel, John D.

1980-01-01

All present and past USGS observation wells for the State of Iowa since 1935 are listed and located on maps. It is recommended that improvement of the observation-well network by the addition of wells in specific areas should be undertaken as soon as possible.

Catchment hydro-biogeochemical response to climate change and future land-use

EPA Science Inventory

The potential interacting effects of climate change and future land-use on hydrological and biogeochemical dynamics rarely have been described at the catchment level and are difficult or impossible to capture through experimentation or observation alone. We apply a new model, Vi...

Behavioural inventory of the giraffe (Giraffa camelopardalis).

PubMed

Seeber, Peter A; Ciofolo, Isabelle; Ganswindt, André

2012-11-22

Numerous factors like continuous habitat reduction or fragmentation for free-ranging giraffes (Giraffa camelopardalis) as well as e.g. suboptimal housing conditions for animals in captivity might lead to behavioural alterations as part of the overall adaptation process to the changing living conditions. In order to facilitate current and future studies on giraffe behaviour, a comprehensive ethogram was compiled based on existing literature, as well as observations on giraffes in the wild (Hwange National Park, Zimbabwe; Entabeni Game Reserve, South Africa), and in captivity (National Zoological Gardens of South Africa, Pretoria). The resulting ethogram lists 65 different behavioural patterns, which were described and grouped into seven categories: General activities, Abnormal repetitive behaviours, General interactions, Bull-Cow behaviour, Bull-Bull behaviour, Cow-Bull behaviour, Maternal behaviours, and Interactions by calves. The behaviours were further described regarding a presumed purpose, particularly with respect to social interactions and sexual behaviour. Contradictory descriptions from previous studies were considered and discussed in comparison with our own observations. This ethogram provides a basis for current and future studies by suggesting a terminology which can be used for harmonizing behavioural observations, thus helping to facilitate comparability of future results. Subsequently, a better understanding of the behavioural ecology of giraffes in the wild as well as in captivity could aid future conservation efforts.

Behavioural inventory of the giraffe (Giraffa camelopardalis)

PubMed Central

2012-01-01

Background Numerous factors like continuous habitat reduction or fragmentation for free-ranging giraffes (Giraffa camelopardalis) as well as e.g. suboptimal housing conditions for animals in captivity might lead to behavioural alterations as part of the overall adaptation process to the changing living conditions. In order to facilitate current and future studies on giraffe behaviour, a comprehensive ethogram was compiled based on existing literature, as well as observations on giraffes in the wild (Hwange National Park, Zimbabwe; Entabeni Game Reserve, South Africa), and in captivity (National Zoological Gardens of South Africa, Pretoria). Findings The resulting ethogram lists 65 different behavioural patterns, which were described and grouped into seven categories: General activities, Abnormal repetitive behaviours, General interactions, Bull-Cow behaviour, Bull-Bull behaviour, Cow-Bull behaviour, Maternal behaviours, and Interactions by calves. The behaviours were further described regarding a presumed purpose, particularly with respect to social interactions and sexual behaviour. Contradictory descriptions from previous studies were considered and discussed in comparison with our own observations. Conclusions This ethogram provides a basis for current and future studies by suggesting a terminology which can be used for harmonizing behavioural observations, thus helping to facilitate comparability of future results. Subsequently, a better understanding of the behavioural ecology of giraffes in the wild as well as in captivity could aid future conservation efforts. PMID:23173954

Double elementary Goldstone Higgs boson production in future linear colliders

NASA Astrophysics Data System (ADS)

Guo, Yu-Chen; Yue, Chong-Xing; Liu, Zhi-Cheng

2018-03-01

The Elementary Goldstone Higgs (EGH) model is a perturbative extension of the Standard Model (SM), which identifies the EGH boson as the observed Higgs boson. In this paper, we study pair production of the EGH boson in future linear electron positron colliders. The cross-sections in the TeV region can be changed to about ‑27%, 163% and ‑34% for the e+e‑→ Zhh, e+e‑→ νν¯hh and e+e‑→ tt¯hh processes with respect to the SM predictions, respectively. According to the expected measurement precisions, such correction effects might be observed in future linear colliders. In addition, we compare the cross-sections of double SM-like Higgs boson production with the predictions in other new physics models.

Plasma Outflows: Known Knowns, Known Unknowns, and The Unknown

NASA Technical Reports Server (NTRS)

Moore, T. E.

2012-01-01

A brief summary is given of i) what we know from observing ionospheric outflows and ii) how outflow parameterizations are being used in global simulations to evaluate their effects on magnetospheric dynamics. Then, a list of unanswered questions and issues to be resolved is given, followed by a description of the known future mission plans expressed in the Heliophysics Roadmap, such as Origin of Near-Earth Plasmas (ONEP), and Ion-Neutral Coupling in the Atmosphere (INCA). Finally, a set of requirements for definitive plasma outflow observations are identified, along with possible methods for fulfilling them in future missions. Since results of the current Heliophysics Decadal Survey are expected soon, it is hoped that future plans can be summarized and discussed without speculation at the GEM 2012 meeting.

Cosmological wheel of time: A classical perspective of f(R) gravity

NASA Astrophysics Data System (ADS)

Yadav, Bal Krishna; Verma, Murli Manohar

It is shown that the structures in the universe can be interpreted to show a closed wheel of time, rather than a straight arrow. An analysis in f(R) gravity model has been carried out to show that due to local observations, a small arc at any given spacetime point would invariably indicate an arrow of time from past to future, though on a quantum scale it is not a linear flow but a closed loop, a fact that can be examined through future observations.

Thermal Diffusivity and Conductivity in Ceramic Matrix Fiber Composite Materials - Literature Study

DOE Office of Scientific and Technical Information (OSTI.GOV)

R.G. Quinn

A technical literature review was conducted to gain an understanding of the state of the art method, problems, results, and future of thermal diffusivity/conductivity of matrix-fiber composites for high temperature applications. This paper summarizes the results of test method development and theory. Results from testing on various sample types are discussed with concentration on the anisotropic characteristics of matrix-fiber composites, barriers to heat flow, and notable microstructure observations. The conclusion presents some observations from the technical literature, drawbacks of current information and discusses potential needs for future testing.

Constraining the range of Yukawa gravity interaction from S2 star orbits III: improvement expectations for graviton mass bounds

NASA Astrophysics Data System (ADS)

Zakharov, A. F.; Jovanović, P.; Borka, D.; Borka Jovanović, V.

2018-04-01

Recently, the LIGO-Virgo collaboration discovered gravitational waves and in their first publication on the subject the authors also presented a graviton mass constraint as mg < 1.2 × 10‑22 eV [1] (see also more details in a complimentary paper [2]). In our previous papers we considered constraints on Yukawa gravity parameters [3] and on graviton mass from analysis of the trajectory of S2 star near the Galactic Center [4]. In the paper we analyze a potential to reduce upper bounds for graviton mass with future observational data on trajectories of bright stars near the Galactic Center. Since gravitational potentials are different for these two cases, expressions for relativistic advance for general relativity and Yukawa potential are different functions on eccentricity and semimajor axis, it gives an opportunity to improve current estimates of graviton mass with future observational facilities. In our considerations of an improvement potential for a graviton mass estimate we adopt a conservative strategy and assume that trajectories of bright stars and their apocenter advance will be described with general relativity expressions and it gives opportunities to improve graviton mass constraints. In contrast with our previous studies, where we present current constraints on parameters of Yukawa gravity [5] and graviton mass [6] from observations of S2 star, in the paper we express expectations to improve current constraints for graviton mass, assuming the GR predictions about apocenter shifts will be confirmed with future observations. We concluded that if future observations of bright star orbits during around fifty years will confirm GR predictions about apocenter shifts of bright star orbits it give an opportunity to constrain a graviton mass at a level around 5 × 10‑23 eV or slightly better than current estimates obtained with LIGO observations.

An empirical perspective for understanding climate change impacts in Switzerland

USGS Publications Warehouse

Henne, Paul; Bigalke, Moritz; Büntgen, Ulf; Colombaroli, Daniele; Conedera, Marco; Feller, Urs; Frank, David; Fuhrer, Jürg; Grosjean, Martin; Heiri, Oliver; Luterbacher, Jürg; Mestrot, Adrien; Rigling, Andreas; Rössler, Ole; Rohr, Christian; Rutishauser, This; Schwikowski, Margit; Stampfli, Andreas; Szidat, Sönke; Theurillat, Jean-Paul; Weingartner, Rolf; Wilcke, Wolfgan; Tinner, Willy

2018-01-01

Planning for the future requires a detailed understanding of how climate change affects a wide range of systems at spatial scales that are relevant to humans. Understanding of climate change impacts can be gained from observational and reconstruction approaches and from numerical models that apply existing knowledge to climate change scenarios. Although modeling approaches are prominent in climate change assessments, observations and reconstructions provide insights that cannot be derived from simulations alone, especially at local to regional scales where climate adaptation policies are implemented. Here, we review the wealth of understanding that emerged from observations and reconstructions of ongoing and past climate change impacts in Switzerland, with wider applicability in Europe. We draw examples from hydrological, alpine, forest, and agricultural systems, which are of paramount societal importance, and are projected to undergo important changes by the end of this century. For each system, we review existing model-based projections, present what is known from observations, and discuss how empirical evidence may help improve future projections. A particular focus is given to better understanding thresholds, tipping points and feedbacks that may operate on different time scales. Observational approaches provide the grounding in evidence that is needed to develop local to regional climate adaptation strategies. Our review demonstrates that observational approaches should ideally have a synergistic relationship with modeling in identifying inconsistencies in projections as well as avenues for improvement. They are critical for uncovering unexpected relationships between climate and agricultural, natural, and hydrological systems that will be important to society in the future.

Ali Observatory in Tibet: a unique northern site for future CMB ground-based observations

NASA Astrophysics Data System (ADS)

Su, Meng

2015-08-01

Ground-based CMB observations have been performed at the South Pole and the Atacama desert in Chile. However, a significant fraction of the sky can not be observed from just these two sites. For a full sky coverage from the ground in the future, a northern site for CMB observation, in particular CMB polarization, is required. Besides the long-thought site in Greenland, the high altitude Tibet plateau provides another opportunity. I will describe the Ali Observatory in Tibet, located at N32°19', E80°01', as a potential site for ground-based CMB observations. The new site is located on almost 5100m mountain, near Gar town, where is an excellent site for both infrared and submillimeter observations. Study with the long-term database of ground weather stations and archival satellite data has been performed. The site has enough relative height on the plateau and is accessible by car. The Shiquanhe town is 40 mins away by driving, and a recently opened airport with 40 mins driving, the site also has road excess, electricity, and optical fiber with fast internet. Preliminary measurement of the Precipitable Water Vapor is ~one quarter less than 0.5mm per year and the long term monitoring is under development. In addition, surrounding higher sites are also available and could be further developed if necessary. Ali provides unique northern sky coverage and together with the South Pole and the Atacama desert, future CMB observations will be able to cover the full sky from ground.

Myth, Allusion, and Education.

ERIC Educational Resources Information Center

Gray-Whiteley, Peter

This paper attempts to reconcile the notion of a planetary future with shamanism, presenting the theme that any planetary future will be severely diminished unless shamanic experiences and outcomes are considered in the understanding of education. Methodology was based on participant observation conducted at a medicine lodge at Bengal Mountain,…

Developing future precipitation events from historic events: An Amsterdam case study.

NASA Astrophysics Data System (ADS)

Manola, Iris; van den Hurk, Bart; de Moel, Hans; Aerts, Jeroen

2016-04-01

Due to climate change, the frequency and intensity of extreme precipitation events is expected to increase. It is therefore of high importance to develop climate change scenarios tailored towards the local and regional needs of policy makers in order to develop efficient adaptation strategies to reduce the risks from extreme weather events. Current approaches to tailor climate scenarios are often not well adopted in hazard management, since average changes in climate are not a main concern to policy makers, and tailoring climate scenarios to simulate future extremes can be complex. Therefore, a new concept has been introduced recently that uses known historic extreme events as a basis, and modifies the observed data for these events so that the outcome shows how the same event would occur in a warmer climate. This concept is introduced as 'Future Weather', and appeals to the experience of stakeholders and users. This research presents a novel method of projecting a future extreme precipitation event, based on a historic event. The selected precipitation event took place over the broader area of Amsterdam, the Netherlands in the summer of 2014, which resulted in blocked highways, disruption of air transportation, flooded buildings and public facilities. An analysis of rain monitoring stations showed that an event of such intensity has a 5 to 15 years return period. The method of projecting a future event follows a non-linear delta transformation that is applied directly on the observed event assuming a warmer climate to produce an "up-scaled" future precipitation event. The delta transformation is based on the observed behaviour of the precipitation intensity as a function of the dew point temperature during summers. The outcome is then compared to a benchmark method using the HARMONIE numerical weather prediction model, where the boundary conditions of the event from the Ensemble Prediction System of ECMWF (ENS) are perturbed to indicate a warmer climate. The two methodologies are statistically compared and evaluated. The comparison between the historic event generated by the model and the observed event will give information on the realism of the model for this event. The comparison between the delta transformation method and the future simulation will provide information on how the dynamics would affect the precipitation field, as compared to the statistical method.

Lubrication of space systems

NASA Technical Reports Server (NTRS)

Fusaro, Robert L.

1994-01-01

NASA has many high-technology programs plannned for the future, such as the space station, Mission to Planet Earth (a series of Earth-observing satellites), space telescopes, and planetary orbiters. These missions will involve advanced mechanical moving components, space mechanisms that will need wear protection and lubrication. The tribology practices used in space today are primarily based on a technology that is more than 20 years old. The question is the following: Is this technology base good enough to meet the needs of these future long-duration NASA missions? This paper examines NASA's future space missions, how mechanisms are currently lubricated, some of the mechanism and tribology challenges that may be encountered in future missions, and some potential solutions to these future challenges.

NASA Satellite Observations: A Unique Asset for the Study of the Environment and Implications for Public Health

NASA Technical Reports Server (NTRS)

Estes Sue M.

2010-01-01

This slide presentation highlights how satellite observation systems are assets for studying the environment in relation to public health. It includes information on current and future satellite observation systems, NASA's public health and safety research, surveillance projects, and NASA's public health partners.

Observations of sea ice and icebergs from satellite radar altimeters

NASA Technical Reports Server (NTRS)

Rapley, C. G.

1984-01-01

Satellite radar altimeters can make useful contributions to the study of sea ice both by enhancing observations from other instruments and by providing a unique probe of ocean-ice interaction in the Marginal Ice Zone (MIZ). The problems, results and future potential of such observations are discussed.

Getting Ready for BepiColombo: A Modeling Approach to Infer the Solar Wind Plasma Parameters Upstream of Mercury from Magnetic Field Observations

NASA Astrophysics Data System (ADS)

Fatemi, S.; Poirier, N.; Holmström, M.; Wieser, M.; Barabash, S.

2018-05-01

We have developed a model to infer the solar wind plasma parameters upstream of Mercury from magnetic field observations in Mercury's magnetosphere. This is important for observations by MESSENGER and the future mission to Mercury, BepiColombo.

Keeping the lights on for global ocean salinity observation

DOE PAGES

Durack, Paul J.; Lee, Tong; Vinogradova, Nadya T.; ...

2016-02-24

Here, insights about climate are being uncovered thanks to improved capacities to observe ocean salinity, an essential climate variable. However, cracks are beginning to appear in the ocean observing system that require prompt attention if we are to maintain the existing, hard-won capacity into the near future.

Keeping the lights on for global ocean salinity observation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Durack, Paul J.; Lee, Tong; Vinogradova, Nadya T.

Here, insights about climate are being uncovered thanks to improved capacities to observe ocean salinity, an essential climate variable. However, cracks are beginning to appear in the ocean observing system that require prompt attention if we are to maintain the existing, hard-won capacity into the near future.

Secret Characters: The Interaction of Narrative and Technology.

ERIC Educational Resources Information Center

Jones, Gwyneth

2002-01-01

Presents an autobiographical sketch of a science fiction writer's relationship with the Information Technology revolution, from the Commodore PET to Microsoft 2000: a creator of imaginary futures privileged to observe an "imaginary future" in the act of becoming present reality. Touches on the nature of narrative and technology, the changing…

Teaching Them to Teach: Programmatic Evaluation of Graduate Assistants' Teaching Performance

ERIC Educational Resources Information Center

Sobel, Karen; Avery, Susan; Ferrer-Vinent, Ignacio J.

2016-01-01

Academic libraries are one of the most important sources of "on the job" training for future library instructors. Librarians who supervise and assess these future library instructors (often in graduate assistant positions) often choose to provide observations and feedback each semester to these instructors in training. Scholarly…

Professional Counseling: Transitioning into the Next Millennium.

ERIC Educational Resources Information Center

Dixon, Charlotte G., Ed.; Emener, William G., Ed.

The purpose of this book is to attempt to forecast the future of professional counseling as it transitions into the next millennium. It is designed to help professional counselors understand and prepare for future changes in the profession of counseling. Understanding the rationale and observable predictors of anticipated changes meaningfully…

Strategising for the future Indian EO programme

NASA Astrophysics Data System (ADS)

Rao, Mukund; Jayaraman, V.; Kalyanraman, S.; Joseph, George; Navalgund, R. R.; Kasturirangan, K.

2002-07-01

The Indian Earth Observations Program, over the past three decades, has been mainly driven by the national need of natural resources management, infrastructure development, environment monitoring and disaster management support. With an array of seven Indian Remote Sensing Satellites (IRS), national development support has been supported, through a well-knit institutional framework of a National Natural Resources Management System (NNRMS), a wide variety of applications developed as an inter-agency effort over the past 20 years. Now, the capacity of the programme has been extended into the global arena and IRS is providing operational data services to the global user community. The future Earth Observation Systems will have to take into consideration the aspects related to the commercialisation and standardisation of programmes world-over; transitioning into a business environment; data continuity and the need to monitor processes rather than events. Technological changes are also going to re-define many of the concepts of observation from space and issues like spatial resolution, spectral resolution and temporal resolution may no more be a concern for observation systems. ISRO is presently defining a strategy for the Indian EO Programme that will chart the progress with a vision for the next 25 years. Based on a thorough analysis, the observation needs of the future are planned and presently systems design and implementation are underway. The Need Analysis has been done keeping in mind the Global change applications; Mapping and Cartographic applications; Natural Resources and Environmental management applications etc. Issues related to defining the space and data acquisition as a national "public good", costing of data products and services and evolving a commercial remote sensing policy have been addressed for providing the overall thrust of the Indian Earth Observations program. The paper discusses the strategy adopted for assessing the future user requirements and also for defining the future Indian missions - which are applications specific solutions. The paper discusses the evolution of the strategy, in the early stages now, and its transition to support a two-pronged strategy of supporting national development and, at the same time, developing a commercial business enterprise. The need to generate newer user segments and develop newer services and products has been recognised from the utilisation point of view. The impact on utilisation accruing from these proposed missions has also been assessed and is discussed in the paper.

Observations from Space and the Future of Meteorology

ERIC Educational Resources Information Center

Tepper, Morris

1974-01-01

Describes space-based observations and other aspects of meterology that will enable weather forecasters to lengthen the scale of predictability from the current day-to-day basis to one week or longer. (Author/GS)

(abstract) Infrared Cirrus and Future Space Based Astronomy

NASA Technical Reports Server (NTRS)

Gautier, T. N.

1993-01-01

A review of the known properties of the distribution of infrared cirrus is followed by a discussion of the implications of cirrus on observations from space. Probable limitations on space observations due to IR cirrus.

Phenomenological Characteristics of Future Thinking in Alzheimer's Disease.

PubMed

Moustafa, Ahmed A; El Haj, Mohamad

2018-05-11

This study investigates phenomenological reliving of future thinking in Alzheimer's disease (AD) patients and matched controls. All participants were asked to imagine in detail a future event, and afterward, were asked to rate phenomenological characteristics of their future thinking. As compared to controls, AD participants showed poor rating for reliving, travel in time, visual imagery, auditory imagery, language, and spatiotemporal specificity. However, no significant differences were observed between both groups in emotion and importance of future thinking. Results also showed lower rating for visual imagery relative to remaining phenomenological features in AD participants compared to controls; conversely, these participants showed higher ratings for emotion and importance of future thinking. AD seems to compromise some phenomenological characteristics of future thinking, especially, visual imagery; however, other phenomenological characteristics, such as emotion, seem to be relatively preserved in these populations. By highlighting the phenomenological experience of future thinking in AD, our paper opens a unique window into the conscious experience of the future in AD patients.

Testing Earth System Models with Earth System Data: using C isotopes in atmospheric CO2 to probe stomatal response to future climate change

NASA Astrophysics Data System (ADS)

Ballantyne, A. P.; Miller, J. B.; Bowling, D. R.; Tans, P. P.; Baker, I. T.

2013-12-01

The global cycles of water and carbon are inextricably linked through photosynthesis. This link is largely governed by stomatal conductance that regulates water loss to the atmosphere and carbon gain to the biosphere. Although extensive research has focused on the response of stomatal conductance to increased atmospheric CO2, much less research has focused on the response of stomatal conductance to concomitant climate change. Here we make use of intensive and extensive measurements of C isotopes in source CO2 to the atmosphere (del-bio) to make inferences about stomatal response to climatic factors at a single forest site and across a network of global observation sites. Based on intensive observations at the Niwot Ridge Ameriflux site we discover that del-bio is an excellent physical proxy of stomatal response during the growing season and this response is highly sensitive to atmospheric water vapor pressure deficit (VPD). We use these intensive single forest site observations to inform our analysis of the global observation network, focusing in on the growing season across an array of terrestrial sites. We find that stomatal response across most of these terrestrial sites is also highly sensitive to VPD. Lastly, we simulate the response of future climate change on stomatal response and discover that future increases in VPD may limit the biosphere's capacity to assimilate future CO2 emissions. These results have direct implications for the benchmarking of Earth System Models as stomatal conductance in many of these models does not vary as a function of VPD.

Impact of episodic thinking on altruism

PubMed Central

Yi, Richard; Pickover, Alison; Stuppy-Sullivan, Allison M.; Baker, Sydney; Landes, Reid D.

2016-01-01

Episodic future thinking, which refers to the use of prospective imagery to concretely imagine oneself in future scenarios, has been shown to reduce delay discounting (enhance self-control). A parallel approach, in which prospective imagery is used to concretely imagine other’s scenarios, may similarly reduce social discounting (i.e., enhance altruism). In study 1, participants engaged in episodic thinking about the self or others, in a repeated-measures design, while completing a social discounting task. Reductions in social discounting were observed as a function of episodic thinking about others, though an interaction with order was also observed. Using an independent-measures design in study 2, the effect of episodic thinking about others was replicated. Study 3 addressed a limitation of studies 1 and 2, the possibility that simply thinking about others decreased social discounting. Capitalizing on Construal Level Theory, which specifies that social distance and time in the future are both dimensions of a common psychological distance, we hypothesized that episodic future thinking should also decrease social discounting. Participants engaged in episodic future thinking or episodic present thinking, in a repeated-measures design, while completing a social discounting task. The pattern of results was similar to study 1, providing support for the notion that episodic thinking about psychologically distant outcomes (for others or in the future) reduces social discounting. Application of similar episodic thinking approaches may enhance altruism. PMID:27821875

On the use and the performance of software reliability growth models

NASA Technical Reports Server (NTRS)

Keiller, Peter A.; Miller, Douglas R.

1991-01-01

We address the problem of predicting future failures for a piece of software. The number of failures occurring during a finite future time interval is predicted from the number failures observed during an initial period of usage by using software reliability growth models. Two different methods for using the models are considered: straightforward use of individual models, and dynamic selection among models based on goodness-of-fit and quality-of-prediction criteria. Performance is judged by the relative error of the predicted number of failures over future finite time intervals relative to the number of failures eventually observed during the intervals. Six of the former models and eight of the latter are evaluated, based on their performance on twenty data sets. Many open questions remain regarding the use and the performance of software reliability growth models.

Predicting uncertainty in future marine ice sheet volume using Bayesian statistical methods

NASA Astrophysics Data System (ADS)

Davis, A. D.

2015-12-01

The marine ice instability can trigger rapid retreat of marine ice streams. Recent observations suggest that marine ice systems in West Antarctica have begun retreating. However, unknown ice dynamics, computationally intensive mathematical models, and uncertain parameters in these models make predicting retreat rate and ice volume difficult. In this work, we fuse current observational data with ice stream/shelf models to develop probabilistic predictions of future grounded ice sheet volume. Given observational data (e.g., thickness, surface elevation, and velocity) and a forward model that relates uncertain parameters (e.g., basal friction and basal topography) to these observations, we use a Bayesian framework to define a posterior distribution over the parameters. A stochastic predictive model then propagates uncertainties in these parameters to uncertainty in a particular quantity of interest (QoI)---here, the volume of grounded ice at a specified future time. While the Bayesian approach can in principle characterize the posterior predictive distribution of the QoI, the computational cost of both the forward and predictive models makes this effort prohibitively expensive. To tackle this challenge, we introduce a new Markov chain Monte Carlo method that constructs convergent approximations of the QoI target density in an online fashion, yielding accurate characterizations of future ice sheet volume at significantly reduced computational cost.Our second goal is to attribute uncertainty in these Bayesian predictions to uncertainties in particular parameters. Doing so can help target data collection, for the purpose of constraining the parameters that contribute most strongly to uncertainty in the future volume of grounded ice. For instance, smaller uncertainties in parameters to which the QoI is highly sensitive may account for more variability in the prediction than larger uncertainties in parameters to which the QoI is less sensitive. We use global sensitivity analysis to help answer this question, and make the computation of sensitivity indices computationally tractable using a combination of polynomial chaos and Monte Carlo techniques.

Current systematic carbon-cycle observations and the need for implementing a policy-relevant carbon observing system

Treesearch

P. Ciais; A. J. Dolman; A. Bombelli; R. Duren; A. Peregon; P. J. Rayner; C. Miller; N. Gobron; G. Kinderman; G. Marland; N. Gruber; F. Chevallier; R. J. Andres; G. Balsamo; L. Bopp; F.-M. Bréon; G. Broquet; R. Dargaville; T. J. Battin; A. Borges; H. Bovensmann; M. Buchwitz; J. Butler; J. G. Canadell; R. B. Cook; R. DeFries; R. Engelen; K. R. Gurney; C. Heinze; M. Heimann; A. Held; M. Henry; B. Law; S. Luyssaert; J. Miller; T. Moriyama; C. Moulin; R. B. Myneni; C. Nussli; M. Obersteiner; D. Ojima; Y. Pan; J.-D. Paris; S. L. Piao; B. Poulter; S. Plummer; S. Quegan; P. Raymond; M. Reichstein; L. Rivier; C. Sabine; D. Schimel; O. Tarasova; R. Valentini; R. Wang; G. van der Werf; D. Wickland; M. Williams; C. Zehner

2014-01-01

A globally integrated carbon observation and analysis system is needed to improve the fundamental understanding of the global carbon cycle, to improve our ability to project future changes, and to verify the effectiveness of policies aiming to reduce greenhouse gas emissions and increase carbon sequestration. Building an integrated carbon observation system requires...

Evolution of the phase 2 preparation and observation tools at ESO

NASA Astrophysics Data System (ADS)

Dorigo, D.; Amarand, B.; Bierwirth, T.; Jung, Y.; Santos, P.; Sogni, F.; Vera, I.

2012-09-01

Throughout the course of many years of observations at the VLT, the phase 2 software applications supporting the specification, execution and reporting of observations have been continuously improved and refined. Specifically the introduction of astronomical surveys propelled the creation of new tools to express more sophisticated, longer-term observing strategies often consisting of several hundreds of observations. During the execution phase, such survey programs compete with other service and visitor mode observations and a number of constraints have to be considered. In order to maximize telescope utilization and execute all programs in a fair way, new algorithms have been developed to prioritize observable OBs taking into account both current and future constraints (e.g. OB time constraints, technical telescope time) and suggest the next OB to be executed. As a side effect, a higher degree of observation automation enables operators to run telescopes mostly autonomously with little supervision by a support astronomer. We describe the new tools that have been deployed and the iterative and incremental software development process applied to develop them. We present our key software technologies used so far and discuss potential future evolution both in terms of features as well as software technologies.

Why do we find ourselves around a yellow star instead of a red star?

NASA Astrophysics Data System (ADS)

Haqq-Misra, Jacob; Kopparapu, Ravi Kumar; Wolf, Eric T.

2018-01-01

M-dwarf stars are more abundant than G-dwarf stars, so our position as observers on a planet orbiting a G-dwarf raises questions about the suitability of other stellar types for supporting life. If we consider ourselves as typical, in the anthropic sense that our environment is probably a typical one for conscious observers, then we are led to the conclusion that planets orbiting in the habitable zone of G-dwarf stars should be the best place for conscious life to develop. But such a conclusion neglects the possibility that K-dwarfs or M-dwarfs could provide more numerous sites for life to develop, both now and in the future. In this paper we analyse this problem through Bayesian inference to demonstrate that our occurrence around a G-dwarf might be a slight statistical anomaly, but only the sort of chance event that we expect to occur regularly. Even if M-dwarfs provide more numerous habitable planets today and in the future, we still expect mid G- to early K-dwarfs stars to be the most likely place for observers like ourselves. This suggests that observers with similar cognitive capabilities as us are most likely to be found at the present time and place, rather than in the future or around much smaller stars.

Probing the Higgs with angular observables at future e +e – colliders

DOE Office of Scientific and Technical Information (OSTI.GOV)

Liu, Zhen

In this paper, I summarize our recent works on using differential observables to explore the physics potential of future e +e – colliders in the framework of Higgs effective field theory. This proceeding is based upon Refs. 1 and 2. We study angular observables in the e +e – → ZHℓ +ℓ –bmore » $$\\bar{b}$$ channel at future circular e +e – colliders such as CEPC and FCC-ee. Taking into account the impact of realistic cut acceptance and detector effects, we forecast the precision of six angular asymmetries at CEPC (FCC-ee) with center-of-mass energy √s = 240 GeV and 5 (30) ab –1 integrated luminosity. We then determine the projected sensitivity to a range of operators relevant for the Higgsstrahlung process in the dimension-6 Higgs EFT. Our results show that angular observables provide complementary sensitivity to rate measurements when constraining various tensor structures arising from new physics. We further find that angular asymmetries provide a novel means of constraining the “blind spot” in indirect limits on supersymmetric scalar top partners. Finally, we also discuss the possibility of using ZZ-fusion at e +e – machines at different energies to probe new operators.« less

Possibility of microscopic liquid water formation at landing sites on Mars and their observational potential

NASA Astrophysics Data System (ADS)

Pál, B.; Kereszturi, Á.

2017-01-01

Microscopic liquid brines, especially calcium-perchlorate could emerge by deliquescence on Mars during night time hours. Using climate model computations and orbital humidity observations, the ideal periods and their annual plus daily characteristics at various past, current and future landing sites were compared. Such results provide context for future analysis and targeting the related observations by the next missions for Mars. Based on the analysis, at most (but not all) past missions' landing sites, microscopic brine could emerge during night time for different durations. Analysing the conditions at ExoMars rover's primary landing site at Oxia Planum, the best annual period was found to be between Ls 115-225, and in Local Time 2-5, after midnight. In an ideal case, 4 h of continuous liquid phase can emerge there. Local conditions might cause values to differ from those estimated by the model. Thermal inertia could especially make such differences (low TI values favour fast cooling and H2O cold trapping at loose surfaces) and the concentration of calcium-perchlorate salt in the regolith also influences the process (it might occur preferentially at long-term exposed surfaces without recent loose dust coverage). These factors should be taken into account while targeting future liquid water observations on Mars.

Probing the Higgs with angular observables at future e +e – colliders

DOE PAGES

Liu, Zhen

2016-10-24

In this paper, I summarize our recent works on using differential observables to explore the physics potential of future e +e – colliders in the framework of Higgs effective field theory. This proceeding is based upon Refs. 1 and 2. We study angular observables in the e +e – → ZHℓ +ℓ –bmore » $$\\bar{b}$$ channel at future circular e +e – colliders such as CEPC and FCC-ee. Taking into account the impact of realistic cut acceptance and detector effects, we forecast the precision of six angular asymmetries at CEPC (FCC-ee) with center-of-mass energy √s = 240 GeV and 5 (30) ab –1 integrated luminosity. We then determine the projected sensitivity to a range of operators relevant for the Higgsstrahlung process in the dimension-6 Higgs EFT. Our results show that angular observables provide complementary sensitivity to rate measurements when constraining various tensor structures arising from new physics. We further find that angular asymmetries provide a novel means of constraining the “blind spot” in indirect limits on supersymmetric scalar top partners. Finally, we also discuss the possibility of using ZZ-fusion at e +e – machines at different energies to probe new operators.« less

Future Missions for Space Weather Specifications and Forecasts

NASA Astrophysics Data System (ADS)

Onsager, T. G.; Biesecker, D. A.; Anthes, R. A.; Maier, M. W.; Gallagher, F. W., III; St Germain, K.

2017-12-01

The progress of technology and the global integration of our economic and security infrastructures have introduced vulnerabilities to space weather that demand a more comprehensive ability to specify and to predict the dynamics of the space environment. This requires a comprehensive network of real-time space-based and ground-based observations with long-term continuity. In order to determine the most cost effective space architectures for NOAA's weather, space weather, and environmental missions, NOAA conducted the NOAA Satellite Observing System Architecture (NSOSA) study. This presentation will summarize the process used to document the future needs and the relative priorities for NOAA's operational space-based observations. This involves specifying the most important observations, defining the performance attributes at different levels of capability, and assigning priorities for achieving the higher capability levels. The highest priority observations recommended by the Space Platform Requirements Working Group (SPRWG) for improvement above a minimal capability level will be described. Finally, numerous possible satellite architectures have been explored to assess the costs and benefits of various architecture configurations.

The CEOS Atmospheric Composition Constellation: Enhancing the Value of Space-Based Observations

NASA Technical Reports Server (NTRS)

Eckman, Richard; Zehner, Claus; Al-Saadi, Jay

2015-01-01

The Committee on Earth Observation Satellites (CEOS) coordinates civil space-borne observations of the Earth. Participating agencies strive to enhance international coordination and data exchange and to optimize societal benefit. In recent years, CEOS has collaborated closely with the Group on Earth Observations (GEO) in implementing the Global Earth Observing System of Systems (GEOSS) space-based objectives. The goal of the CEOS Atmospheric Composition Constellation (ACC) is to collect and deliver data to improve monitoring, assessment and predictive capabilities for changes in the ozone layer, air quality and climate forcing associated with changes in the environment through coordination of existing and future international space assets. A project to coordinate and enhance the science value of a future constellation of geostationary sensors measuring parameters relevant to air quality supports the forthcoming European Sentinel-4, Korean GEMS, and US TEMPO missions. Recommendations have been developed for harmonization to mutually improve data quality and facilitate widespread use of the data products.

Understanding climate: A strategy for climate modeling and predictability research, 1985-1995

NASA Technical Reports Server (NTRS)

Thiele, O. (Editor); Schiffer, R. A. (Editor)

1985-01-01

The emphasis of the NASA strategy for climate modeling and predictability research is on the utilization of space technology to understand the processes which control the Earth's climate system and it's sensitivity to natural and man-induced changes and to assess the possibilities for climate prediction on time scales of from about two weeks to several decades. Because the climate is a complex multi-phenomena system, which interacts on a wide range of space and time scales, the diversity of scientific problems addressed requires a hierarchy of models along with the application of modern empirical and statistical techniques which exploit the extensive current and potential future global data sets afforded by space observations. Observing system simulation experiments, exploiting these models and data, will also provide the foundation for the future climate space observing system, e.g., Earth observing system (EOS), 1985; Tropical Rainfall Measuring Mission (TRMM) North, et al. NASA, 1984.

The Italian VLBI Network: First Results and Future Perspectives

NASA Astrophysics Data System (ADS)

Stagni, Matteo; Negusini, Monia; Bianco, Giuseppe; Sarti, Pierguido

2016-12-01

A first 24-hour Italian VLBI geodetic experiment, involving the Medicina, Noto, and Matera antennas, shaped as an IVS standard EUROPE, was successfully performed. In 2014, starting from the correlator output, a geodetic database was created and a typical solution of a small network was achieved, here presented. From this promising result we have planned new observations in 2016, involving the three Italian geodetic antennas. This could be the beginning of a possible routine activity, creating a data set that can be combined with GNSS observations to contribute to the National Geodetic Reference Datum. Particular care should be taken in the scheduling of the new experiments in order to optimize the number of usable observations. These observations can be used to study and plan future experiments in which the time and frequency standards can be given by an optical fiber link, thus having a common clock at different VLBI stations.

Construction of a meteor orbit calculation system for comprehensive meteor observation

NASA Astrophysics Data System (ADS)

Mizumoto, S.; Madkour, W.; Yamamoto, M.

2016-01-01

At Kochi University of Technology (KUT), the development of an HRO (Ham-band Radio meteor Observation) -Interferometer (IF) was started in 2003, and we realized the meteor orbit calculation system by multiple-site radio observation with GPS time-keeping combining with the 5 channel (5ch) HRO-IF in 2012. Here, we introduce a future plan of comprehensive meteor observation by Radio, Optical and Infrasound observation.

Observing the Global Water Cycle from Space

NASA Technical Reports Server (NTRS)

Hildebrand, Peter H.; Houser, Paul; Schlosser, C. Adam

2003-01-01

This paper presents an approach to measuring all major components of the water cycle from space. The goal of the paper is to explore the concept of using a sensor-web of satellites to observe the global water cycle. The details of the required measurements and observation systems are therefore only an initial approach and will undergo future refinement, as their details will be highly important. Key elements include observation and evaluation of all components of the water cycle in terms of the storage of water-in the ocean, air, cloud and precipitation, in soil, ground water, snow and ice, and in lakes and rivers-and in terms of the global fluxes of water between these reservoirs. For each component of the water cycle that must be observed, the appropriate temporal and spatial scales of measurement are estimated, along with the some of the frequencies that have been used for active and passive microwave observations of the quantities. The suggested types of microwave observations are based on the heritage for such measurements, and some aspects of the recent heritage of these measurement algorithms are listed. The observational requirements are based on present observational systems, as modified by expectations for future needs. Approaches to the development of space systems for measuring the global water cycle can be based on these observational requirements.

Historical and Future Projected Hydrologic Extremes over the Midwest and Great Lakes Region

NASA Astrophysics Data System (ADS)

Byun, K.; Hamlet, A. F.; Chiu, C. M.

2016-12-01

There is an increasing body of evidence from observed data that climate variability combined with regional climate change has had a significant impact on hydrologic cycles, including both seasonal patterns of runoff and altered hydrologic extremes (e.g. floods and extreme stormwater events). To better understand changing patterns of extreme high flows in Midwest and Great Lakes region, we analyzed long-term historical observations of peak streamflow at different gaging stations. We also conducted hydrologic model experiments using the Variable Infiltration Capacity (VIC) at 1/16 degree resolution in order to explore sensitivity of annual peak streamflow, both historically and under temperature and precipitation changes for several future periods. For future projections, the Hybrid Delta statistical downscaling approach applied to the Coupled Model Inter-comparison, Phase5 (CMIP5) Global Climate Model (GCM) scenarios was used to produce driving data for the VIC hydrologic model. Preliminary results for several test basins in the Midwest support the hypothesis that there are consistent and statistically significant changes in the mean annual flood starting before and after about 1975. Future projections using hydrologic model simulations support the hypothesis of higher peak flows due to warming and increasing precipitation projected for the 21st century. We will extend this preliminary analysis using observed data and simulations from 40 river basins in the Midwest to further test these hypotheses.

A Statistical Weather-Driven Streamflow Model: Enabling future flow predictions in data-scarce headwater streams

NASA Astrophysics Data System (ADS)

Rosner, A.; Letcher, B. H.; Vogel, R. M.

2014-12-01

Predicting streamflow in headwaters and over a broad spatial scale pose unique challenges due to limited data availability. Flow observation gages for headwaters streams are less common than for larger rivers, and gages with records lengths of ten year or more are even more scarce. Thus, there is a great need for estimating streamflows in ungaged or sparsely-gaged headwaters. Further, there is often insufficient basin information to develop rainfall-runoff models that could be used to predict future flows under various climate scenarios. Headwaters in the northeastern U.S. are of particular concern to aquatic biologists, as these stream serve as essential habitat for native coldwater fish. In order to understand fish response to past or future environmental drivers, estimates of seasonal streamflow are needed. While there is limited flow data, there is a wealth of data for historic weather conditions. Observed data has been modeled to interpolate a spatially continuous historic weather dataset. (Mauer et al 2002). We present a statistical model developed by pairing streamflow observations with precipitation and temperature information for the same and preceding time-steps. We demonstrate this model's use to predict flow metrics at the seasonal time-step. While not a physical model, this statistical model represents the weather drivers. Since this model can predict flows not directly tied to reference gages, we can generate flow estimates for historic as well as potential future conditions.

NASA's Ultraviolet Astrophysics Branch: Present and future detector program

NASA Technical Reports Server (NTRS)

Welsh, Barry Y.

1992-01-01

The various concepts in ultraviolet detector technology currently being funded by NASA's Astrophysics Division to carry out observations in the 100 to 3000 A region are reviewed. In order to match the science objectives of future space missions with new observational techniques, critical detector technology needs in the ultraviolet regime have been identified. The attempt by NASA's Astrophysics Division Advanced Programs Branch to formulate an integrated detector technology plan as part of the ongoing 'Astrotech 21' program in order to provide the technology base for these astrophysics missions of the 21st century is described.

Aerospace century XXI: Space sciences, applications, and commercial developments; Proceedings of the Thirty-third Annual AAS International Conference, Boulder, CO, Oct. 26-29, 1986

DOE Office of Scientific and Technical Information (OSTI.GOV)

Morgenthaler, G.W.; Koster, J.N.

1987-01-01

Papers are presented on rocket UV observations of Comet Halley, a space system for microgravity research, transitioning from Spacelab to Space Station science, and assemblers and future space hardware. Also considered are spatial and temporal scales of atmospheric disturbances, Doppler radar for prediction and warning, data management for the Columbus program, communications satellites of the future, and commercial launch vehicles. Other topics include space geodesy and earthquake predictions, inverted cellular radio satellite systems, material processing in space, and potential for earth observations from the manned Space Station.

New Target for Cosmic Axion Searches.

PubMed

Baumann, Daniel; Green, Daniel; Wallisch, Benjamin

2016-10-21

Future cosmic microwave background experiments have the potential to probe the density of relativistic species at the subpercent level. This sensitivity allows light thermal relics to be detected up to arbitrarily high decoupling temperatures. Conversely, the absence of a detection would require extra light species never to have been in equilibrium with the Standard Model. In this Letter, we exploit this feature to demonstrate the sensitivity of future cosmological observations to the couplings of axions to photons, gluons, and charged fermions. In many cases, the constraints achievable from cosmology will surpass existing bounds from laboratory experiments and astrophysical observations by orders of magnitude.

The main pillar: Assessment of space weather observational asset performance supporting nowcasting, forecasting, and research to operations.

PubMed

Posner, A; Hesse, M; St Cyr, O C

2014-04-01

Space weather forecasting critically depends upon availability of timely and reliable observational data. It is therefore particularly important to understand how existing and newly planned observational assets perform during periods of severe space weather. Extreme space weather creates challenging conditions under which instrumentation and spacecraft may be impeded or in which parameters reach values that are outside the nominal observational range. This paper analyzes existing and upcoming observational capabilities for forecasting, and discusses how the findings may impact space weather research and its transition to operations. A single limitation to the assessment is lack of information provided to us on radiation monitor performance, which caused us not to fully assess (i.e., not assess short term) radiation storm forecasting. The assessment finds that at least two widely spaced coronagraphs including L4 would provide reliability for Earth-bound CMEs. Furthermore, all magnetic field measurements assessed fully meet requirements. However, with current or even with near term new assets in place, in the worst-case scenario there could be a near-complete lack of key near-real-time solar wind plasma data of severe disturbances heading toward and impacting Earth's magnetosphere. Models that attempt to simulate the effects of these disturbances in near real time or with archival data require solar wind plasma observations as input. Moreover, the study finds that near-future observational assets will be less capable of advancing the understanding of extreme geomagnetic disturbances at Earth, which might make the resulting space weather models unsuitable for transition to operations. Manuscript assesses current and near-future space weather assetsCurrent assets unreliable for forecasting of severe geomagnetic stormsNear-future assets will not improve the situation.