Application of AirCell Cellular AMPS Network and Iridium Satellite System Dual Mode Service to Air Traffic Management

NASA Technical Reports Server (NTRS)

Shamma, Mohammed A.

2004-01-01

The AirCell/Iridium dual mode service is evaluated for potential applications to Air Traffic Management (ATM) communication needs. The AirCell system which is largely based on the Advanced Mobile Phone System (AMPS) technology, and the Iridium FDMA/TDMA system largely based on the Global System for Mobile Communications(GSM) technology, can both provide communication relief for existing or future aeronautical communication links. Both have a potential to serve as experimental platforms for future technologies via a cost effective approach. The two systems are well established in the entire CONUS and globally hence making it feasible to utilize in all regions, for all altitudes, and all classes of aircraft. Both systems have been certified for air usage. The paper summarizes the specifications of the AirCell/Iridium system, as well as the ATM current and future links, and application specifications. the paper highlights the scenarios, applications, and conditions under which the AirCell/Iridium technology can be suited for ATM Communication.

The Development of B2C E-Commerce in Greece: Current Situation and Future Potential.

ERIC Educational Resources Information Center

Kardaras, Dimitris; Papathanassiou, Eleutherios

2000-01-01

Reports on the results of a survey of 120 companies in Greece that evaluated the potential of business to customer (B2C) Internet applications and investigated how the Internet and e-commerce can offer new opportunities for businesses to improve their customers' satisfaction. Discusses electronic commerce problems and future technology. (Contains…

Application of adaptive antenna techniques to future commercial satellite communication

NASA Technical Reports Server (NTRS)

Ersoy, L.; Lee, E. A.; Matthews, E. W.

1987-01-01

The purpose of this contract was to identify the application of adaptive antenna technique in future operational commercial satellite communication systems and to quantify potential benefits. The contract consisted of two major subtasks. Task 1, Assessment of Future Commercial Satellite System Requirements, was generally referred to as the Adaptive section. Task 2 dealt with Pointing Error Compensation Study for a Multiple Scanning/Fixed Spot Beam Reflector Antenna System and was referred to as the reconfigurable system. Each of these tasks was further sub-divided into smaller subtasks. It should also be noted that the reconfigurable system is usually defined as an open-loop system while the adaptive system is a closed-loop system. The differences between the open- and closed-loop systems were defined. Both the adaptive and reconfigurable systems were explained and the potential applications of such systems were presented in the context of commercial communication satellite systems.

Application of adaptive antenna techniques to future commercial satellite communications. Executive summary

NASA Technical Reports Server (NTRS)

Ersoy, L.; Lee, E. A.; Matthews, E. W.

1987-01-01

The purpose of this contract was to identify the application of adaptive antenna technique in future operational commercial satellite communication systems and to quantify potential benefits. The contract consisted of two major subtasks. Task 1, Assessment of Future Commercial Satellite System Requirements, was generally referred to as the Adaptive section. Task 2 dealt with Pointing Error Compensation Study for a Multiple Scanning/Fixed Spot Beam Reflector Antenna System and was referred to as the reconfigurable system. Each of these tasks was further subdivided into smaller subtasks. It should also be noted that the reconfigurable system is usually defined as an open-loop system while the adaptive system is a closed-loop system. The differences between the open- and closed-loop systems were defined. Both the adaptive and reconfigurable systems were explained and the potential applications of such systems were presented in the context of commercial communication satellite systems.

A see through future: augmented reality and health information systems.

PubMed

Monkman, Helen; Kushniruk, Andre W

2015-01-01

Augmented Reality (AR) is a method whereby virtual objects are superimposed on the real world. AR technology is becoming increasingly accessible and affordable and it has many potential health applications. This paper discusses current research on AR health applications such as medical education and medical practice. Some of the potential future uses for this technology (e.g., health information systems, consumer health applications) will also be presented. Additionally, there will be a discussion outlining some of usability and human factors challenges associated with AR in healthcare. It is expected that AR will become increasingly prevalent in healthcare; however, further investigation is required to demonstrate that they provide benefits over traditional methods. Moreover, AR applications must be thoroughly tested to ensure they do not introduce new errors into practice and have patient safety implications.

Assessment of the application of advanced technologies to subsonic CTOL transport aircraft

NASA Technical Reports Server (NTRS)

Graef, J. D.; Sallee, G. P.; Verges, J. T.

1974-01-01

Design studies of the application of advanced technologies to future transport aircraft were conducted. These studies were reviewed from the perspective of an air carrier. A fundamental study of the elements of airplane operating cost was performed, and the advanced technologies were ranked in order of potential profit impact. Recommendations for future study areas are given.

An assessment of the status and trends in satellite communications 1986-2000: An information document prepared for the Communications Subcommittee of the Space Applications Advisory Committee

NASA Technical Reports Server (NTRS)

Poley, W. A.; Stevens, G. H.; Stevenson, S. M.; Lekan, J.; Arth, C. H.; Hollansworth, J. E.; Miller, E. F.

1986-01-01

This is a response to a Space Applications Advisory Committee (SAAC) request for information about the status and trends in satellite communications, to be used to support efforts to conceive and recommend long range goals for NASA communications activities. Included in this document are assessments of: (1) the outlook for satellite communications, including current applications, potential future applications, and impact of the changing environment such as optical fiber networks, the Integrated Services Digital Network (ISDN) standard, and the rapidly growing market for Very Small Aperture Terminals (VSAT); (2) the restrictions imposed by our limited spectrum resource; and (3) technology needs indicated by future trends. Potential future systems discussed include: large powerful satellites for providing personal communications; VSAT compatible satellites with onboard switching and having voice capability; large satellites which offer a pervasive T1 network service (primarily for video-phone); and large geostationary communications facilities which support common use by several carriers. Also, discussion is included of NASA particular needs and possible future systems. Based on the mentioned system concepts, specific technology recommendations are provided for the time frames of now - 1993, 1994 - 2000, and 2000 - 2010.

Clinical Utility and Future Applications of PET/CT and PET/CMR in Cardiology

PubMed Central

Pan, Jonathan A.; Salerno, Michael

2016-01-01

Over the past several years, there have been major advances in cardiovascular positron emission tomography (PET) in combination with either computed tomography (CT) or, more recently, cardiovascular magnetic resonance (CMR). These multi-modality approaches have significant potential to leverage the strengths of each modality to improve the characterization of a variety of cardiovascular diseases and to predict clinical outcomes. This review will discuss current developments and potential future uses of PET/CT and PET/CMR for cardiovascular applications, which promise to add significant incremental benefits to the data provided by each modality alone. PMID:27598207

The role of development of photovoltaics for Mongolia

DOE Office of Scientific and Technical Information (OSTI.GOV)

Enebish, N.; Agchbayar, D.; Baatarkhuu, M.

1994-12-31

This paper describes an assessment of the potential applications of photovoltaic technology in Mongolia. Socio-economic conditions of the pastoral culture are described and it is shown that the photovoltaic system is the most suitable source of electricity and has potential for wide application. One application identified is for powering communications systems for herdspeople and other decentralized communities of Mongolian rural areas. Some strategies for the future development and application of photovoltaic systems in Mongolia are discussed.

An examination of the potential applications of automatic classification techniques to Georgia management problems

NASA Technical Reports Server (NTRS)

Rado, B. Q.

1975-01-01

Automatic classification techniques are described in relation to future information and natural resource planning systems with emphasis on application to Georgia resource management problems. The concept, design, and purpose of Georgia's statewide Resource AS Assessment Program is reviewed along with participation in a workshop at the Earth Resources Laboratory. Potential areas of application discussed include: agriculture, forestry, water resources, environmental planning, and geology.

Solving quantum riddles with neutron scattering

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fobes, David M.; Janoschek, Marc

2017-05-16

Quantum materials exhibit a rich landscape of highly-degenerate quantum states that are widely regarded to hold vast potential for future applications, ranging from power management and transmission, to platforms for quantum computation, to novel versatile sensors and electronics. A key to realizing the promise of future applications is to identify the fundamental energy scales that control the emergence of such quantum states and their properties.

The electromagnetic spectrum: current and future applications in oncology.

PubMed

Allison, Ron R

2013-05-01

The electromagnetic spectrum is composed of waves of various energies that interact with matter. When focused upon and directed at tumors, these energy sources can be employed as a means of lesion ablation. While the use of x-rays is widely known in this regard, a growing body of evidence shows that other members of this family can also achieve oncologic success. This article will review therapeutic application of the electromagnetic spectrum in current interventions and potential future applications.

Visual Data Comm: A Tool for Visualizing Data Communication in the Multi Sector Planner Study

NASA Technical Reports Server (NTRS)

Lee, Hwasoo Eric

2010-01-01

Data comm is a new technology proposed in future air transport system as a potential tool to provide comprehensive data connectivity. It is a key enabler to manage 4D trajectory digitally, potentially resulting in improved flight times and increased throughput. Future concepts with data comm integration have been tested in a number of human-in-the-loop studies but analyzing the results has proven to be particularly challenging because future traffic environment in which data comm is fully enabled has assumed high traffic density, resulting in data set with large amount of information. This paper describes the motivation, design, current and potential future application of Visual Data Comm (VDC), a tool for visualizing data developed in Java using Processing library which is a tool package designed for interactive visualization programming. This paper includes an example of an application of VDC on data pertaining to the most recent Multi Sector Planner study, conducted at NASA s Airspace Operations Laboratory in 2009, in which VDC was used to visualize and interpret data comm activities

A review of advanced high performance, insensitive and thermally stable energetic materials emerging for military and space applications.

PubMed

Sikder, A K; Sikder, Nirmala

2004-08-09

Energetic materials used extensively both for civil and military applications. There are continuous research programmes worldwide to develop new materials with higher performance and enhanced insensitivity to thermal or shock insults than the existing ones in order to meet the requirements of future military and space applications. This review concentrates on recent advances in syntheses, potential formulations and space applications of potential compounds with respect to safety, performance and stability.

Field emitter displays for future avionics applications

NASA Astrophysics Data System (ADS)

Jones, Susan K.; Jones, Gary W.; Zimmerman, Steven M.; Blazejewski, Edward R.

1995-06-01

Field emitter array-based display technology offers CRT-like characteristics in a thin flat-panel display with many potential applications for vehicle-mounted, crew workstation, and helmet-mounted displays, as well as many other military and commercial applications. In addition to thinness, high brightness, wide viewing angle, wide temperature range, and low weight, field emitter array displays also offer potential advantages such as row-at-a-time matrix addressability and the ability to be segmented.

Potential and prospective implementation of carbon nanotubes on next generation aircraft and space vehicles: A review of current and expected applications in aerospace sciences

NASA Astrophysics Data System (ADS)

Gohardani, Omid; Elola, Maialen Chapartegui; Elizetxea, Cristina

2014-10-01

Carbon nanotubes have instigated the interest of many different scientific fields since their authenticated introduction, more than two decades ago. Particularly in aerospace applications, the potential implementations of these advanced materials have been predicted to have a large impact on future aircraft and space vehicles, mainly due to their distinct features, which include superior mechanical, thermal and electrical properties. This article provides the very first consolidated review of the imminent prospects of utilizing carbon nanotubes and nanoparticles in aerospace sciences, based on their recent implementations and predicted future applications. Explicitly, expected carbon nanotube employment in aeronautics and astronautics are identified for commercial aircraft, military aircraft, rotorcraft, unmanned aerial vehicles, satellites, and space launch vehicles. Attention is devoted to future utilization of carbon nanotubes, which may comprise hydrogen storage encapsulation, composite material implementation, lightning protection for aircraft, aircraft icing mitigation, reduced weight of airframes/satellites, and alleviation of challenges related to future space launch. This study further sheds light onto recent actualized implementations of carbon nanotubes in aerospace applications, as well as current and prospective challenges related to their usage in aerospace sciences, encompassing health and safety hazards, large scale manufacturing, achievement of optimum properties, recycling, and environmental impacts.

A study of the applicability/compatibility of inertial energy storage systems to future space missions

NASA Technical Reports Server (NTRS)

Weldon, W. F.

1980-01-01

The applicability/compatibility of inertial energy storage systems like the homopolar generator (HPG) and the compensated pulsed alternator (CPA) to future space missions is explored. Areas of CPA and HPG design requiring development for space applications are identified. The manner in which acceptance parameters of the CPA and HPG scale with operating parameters of the machines are explored and the types of electrical loads which are compatible with the CPA and HPG are examined. Potential applications including the magnetoplasmadynamic (MPD) thruster, pulsed data transmission, laser ranging, welding and electromagnetic space launch are discussed.

Selection and Classification Using a Forecast Applicant Pool.

ERIC Educational Resources Information Center

Hendrix, William H.

The document presents a forecast model of the future Air Force applicant pool. By forecasting applicants' quality (means and standard deviations of aptitude scores) and quantity (total number of applicants), a potential enlistee could be compared to the forecasted pool. The data used to develop the model consisted of means, standard deviation, and…

A Framework for Safe Integration of Small UAS Into the NAS

NASA Technical Reports Server (NTRS)

Logan, Michael J.; Bland, Geoffrey; Murray, Jennifer

2011-01-01

This paper discusses a proposed framework for the safe integration of small unmanned aerial systems (sUAS) into the National Airspace System (NAS). The paper examines the potential uses of sUAS to build an understanding of the location and frequency of potential future flight operations based on the future applications of the sUAS systems. The paper then examines the types of systems that would be required to meet the application-level demand to determine classes of platforms and operations. Finally, a framework is proposed for both airworthiness and operations that attempts to balance safety with utility for these important systems.

Purification of Logic-Qubit Entanglement.

PubMed

Zhou, Lan; Sheng, Yu-Bo

2016-07-05

Recently, the logic-qubit entanglement shows its potential application in future quantum communication and quantum network. However, the entanglement will suffer from the noise and decoherence. In this paper, we will investigate the first entanglement purification protocol for logic-qubit entanglement. We show that both the bit-flip error and phase-flip error in logic-qubit entanglement can be well purified. Moreover, the bit-flip error in physical-qubit entanglement can be completely corrected. The phase-flip in physical-qubit entanglement error equals to the bit-flip error in logic-qubit entanglement, which can also be purified. This entanglement purification protocol may provide some potential applications in future quantum communication and quantum network.

Grand Challenges and Future Opportunities for Metal–Organic Frameworks

PubMed Central

2017-01-01

Metal–organic frameworks (MOFs) allow compositional and structural diversity beyond conventional solid-state materials. Continued interest in the field is justified by potential applications of exceptional breadth, ranging from gas storage and separation, which takes advantage of the inherent pores and their volume, to electronic applications, which requires precise control of electronic structure. In this Outlook we present some of the pertinent challenges that MOFs face in their conventional implementations, as well as opportunities in less traditional areas. Here the aim is to discuss select design concepts and future research goals that emphasize nuances relevant to this class of materials as a whole. Particular emphasis is placed on synthetic aspects, as they influence the potential for MOFs in gas separation, electrical conductivity, and catalytic applications. PMID:28691066

Grand Challenges and Future Opportunities for Metal–Organic Frameworks

DOE PAGES

Hendon, Christopher H.; Rieth, Adam J.; Korzyński, Maciej D.; ...

2017-06-06

Metal–organic frameworks (MOFs) allow compositional and structural diversity beyond conventional solid-state materials. Continued interest in the field is justified by potential applications of exceptional breadth, ranging from gas storage and separation, which takes advantage of the inherent pores and their volume, to electronic applications, which requires precise control of electronic structure. In this Outlook we present some of the pertinent challenges that MOFs face in their conventional implementations, as well as opportunities in less traditional areas. Here the aim is to discuss select design concepts and future research goals that emphasize nuances relevant to this class of materials as amore » whole. Particular emphasis is placed on synthetic aspects, as they influence the potential for MOFs in gas separation, electrical conductivity, and catalytic applications.« less

Advanced situation awareness with localised environmental community observatories in the Future Internet

NASA Astrophysics Data System (ADS)

Sabeur, Z. A.; Denis, H.; Nativi, S.

2012-04-01

The phenomenal advances in information and communication technologies over the last decade have led to offering unprecedented connectivity with real potentials for "Smart living" between large segments of human populations around the world. In particular, Voluntary Groups(VGs) and individuals with interest in monitoring the state of their local environment can be connected through the internet and collaboratively generate important localised environmental observations. These could be considered as the Community Observatories(CO) of the Future Internet(FI). However, a set of FI enablers are needed to be deployed for these communities to become effective COs in the Future Internet. For example, these communities will require access to services for the intelligent processing of heterogeneous data and capture of advancend situation awarness about the environment. This important enablement will really unlock the communities true potential for participating in localised monitoring of the environment in addition to their contribution in the creation of business entreprise. Among the eight Usage Areas(UA) projects of the FP7 FI-PPP programme, the ENVIROFI Integrated Project focuses on the specifications of the Future Internet enablers of the Environment UA. The specifications are developed under multiple environmental domains in context of users needs for the development of mash-up applications in the Future Internet. It will enable users access to real-time, on-demand fused information with advanced situation awareness about the environment at localised scales. The mash-up applications shall get access to rich spatio-temporal information from structured fusion services which aggregate COs information with existing environmental monitoring stations data, established by research organisations and private entreprise. These applications are being developed in ENVIROFI for the atmospheric, marine and biodiversity domains, together with a potential to be extended to other domains and scenarios concerning smart and safe living in the Future Internet.

Nanocellulose-stabilized Pickering emulsions and their applications

PubMed Central

Fujisawa, Shuji; Togawa, Eiji; Kuroda, Katsushi

2017-01-01

Abstract Pickering emulsion, which is an emulsion stabilized by solid particles, offers a wide range of potential applications because it generally provides a more stable system than surfactant-stabilized emulsion. Among various solid stabilizers, nanocellulose may open up new opportunities for future Pickering emulsions owing to its unique nanosizes, amphiphilicity, and other favorable properties (e.g. chemical stability, biodegradability, biocompatibility, and renewability). In this review, the preparation and properties of nanocellulose-stabilized Pickering emulsions are summarized. We also provide future perspectives on their applications, such as drug delivery, food, and composite materials. PMID:29383046

Cerium-doped scintillating fused-silica fibers

NASA Astrophysics Data System (ADS)

Akchurin, N.; Cowden, C.; Damgov, J.; Dragoiu, C.; Dudero, P.; Faulkner, J.; Kunori, S.

2018-04-01

We report on a set of measurements made on (scintillating) cerium-doped fused-silica fibers using high-energy particle beams. These fibers were uniformly embedded in a copper absorber in order to utilize electromagnetic showers as a source of charged particles for generating signals. This new type of cerium-doped fiber potentially offers myriad new applications in calorimeters in high-energy physics, tracking systems, and beam monitoring detectors for future applications. The light yield, pulse shape, attenuation length, and light propagation speeds are given and discussed. Possible future applications are also explored.

Nanocellulose-stabilized Pickering emulsions and their applications

NASA Astrophysics Data System (ADS)

Fujisawa, Shuji; Togawa, Eiji; Kuroda, Katsushi

2017-12-01

Pickering emulsion, which is an emulsion stabilized by solid particles, offers a wide range of potential applications because it generally provides a more stable system than surfactant-stabilized emulsion. Among various solid stabilizers, nanocellulose may open up new opportunities for future Pickering emulsions owing to its unique nanosizes, amphiphilicity, and other favorable properties (e.g. chemical stability, biodegradability, biocompatibility, and renewability). In this review, the preparation and properties of nanocellulose-stabilized Pickering emulsions are summarized. We also provide future perspectives on their applications, such as drug delivery, food, and composite materials.

Origin and Future of Plasmonic Optical Tweezers

PubMed Central

Huang, Jer-Shing; Yang, Ya-Tang

2015-01-01

Plasmonic optical tweezers can overcome the diffraction limits of conventional optical tweezers and enable the trapping of nanoscale objects. Extension of the trapping and manipulation of nanoscale objects with nanometer position precision opens up unprecedented opportunities for applications in the fields of biology, chemistry and statistical and atomic physics. Potential applications include direct molecular manipulation, lab-on-a-chip applications for viruses and vesicles and the study of nanoscale transport. This paper reviews the recent research progress and development bottlenecks and provides an overview of possible future directions in this field. PMID:28347051

Origin and Future of Plasmonic Optical Tweezers.

PubMed

Huang, Jer-Shing; Yang, Ya-Tang

2015-06-12

Plasmonic optical tweezers can overcome the diffraction limits of conventional optical tweezers and enable the trapping of nanoscale objects. Extension of the trapping and manipulation of nanoscale objects with nanometer position precision opens up unprecedented opportunities for applications in the fields of biology, chemistry and statistical and atomic physics. Potential applications include direct molecular manipulation, lab-on-a-chip applications for viruses and vesicles and the study of nanoscale transport. This paper reviews the recent research progress and development bottlenecks and provides an overview of possible future directions in this field.

Biosurfactant-induced remediation of contaminated marine sediments: Current knowledge and future perspectives.

PubMed

Dell'Anno, F; Sansone, C; Ianora, A; Dell'Anno, A

2018-06-01

The contamination of marine sediments is widespread in coastal regions of the world and represents a major concern for the potential detrimental consequences on ecosystems' health and provision of goods and services for human wellbeing. Thus, there is an urgent need to find sustainable and eco-compatible solutions for the remediation of contaminated sediments. Bioremediation is a low cost and environmental-friendly strategy with a high potential for the remediation of contaminated marine sediments. Here we review the potential application of biosurfactants produced by microbial taxa for the remediation of contaminated marine sediments and we discuss future research needs to develop efficient and eco-sustainable biosurfactant-based strategies for the recovery of contaminated marine sediments, in view of large-scale applications. Copyright © 2018 Elsevier Ltd. All rights reserved.

Steganography: Past, Present, Future

DOE Office of Scientific and Technical Information (OSTI.GOV)

Judge, J C

Steganography (a rough Greek translation of the term Steganography is secret writing) has been used in various forms for 2500 years. It has found use in variously in military, diplomatic, personal and intellectual property applications. Briefly stated, steganography is the term applied to any number of processes that will hide a message within an object, where the hidden message will not be apparent to an observer. This paper will explore steganography from its earliest instances through potential future application.

Wide Bandgap Semiconductor Opportunities in Power Electronics

DOE Office of Scientific and Technical Information (OSTI.GOV)

Das, Sujit; Marlino, Laura D.; Armstrong, Kristina O.

The report objective is to explore the Wide Bandgap (WBG) Power Electronics (PE) market, applications, and potential energy savings in order to identify key areas where further resources and investments of the U.S. Department of Energy’s Office of Energy Efficiency and Renewable Energy (DOE EERE) would have the most impact on U.S. competiveness. After considering the current market, several potential near-term application areas were identified as having significant market and energy savings potential with respect to clean energy applications: (1) data centers (uninterruptible power supplies and server power supplies); (2) renewable energy generation (photovoltaic-solar and wind); (3) motor drives (industrial,more » commercial and residential); (4) rail traction; and, (5) hybrid and electric vehicles (traction and charging). After the initial explorative analyses, it became clear that, SiC, not GaN, would be the principal WBG power device material for the chosen markets in the near future. Therefore, while GaN is discussed when appropriate, this report focuses on SiC devices, other WBG applications (e.g., solid-state transformers, combined heat and power, medical, and wireless power), the GaN market, and GaN specific applications (e.g., LiDAR, 5G) will be explored at a later date. In addition to the market, supply and value chain analyses addressed in Section 1 of this report, a SWOT (Strength, Weakness, Opportunity, Threat) analysis and potential energy savings analysis was conducted for each application area to identify the major potential WBG application area(s) with a U.S. competitiveness opportunity in the future.« less

Magnetic Resonance Guided Focused Ultrasound Surgery: Part 2 – A Review of Current and Future Applications

PubMed Central

Medel, Ricky; Monteith, Stephen J.; Elias, W. Jeffrey; Eames, Matthew; Snell, John; Sheehan, Jason P.; Wintermark, Max; Jolesz, Ferenc A.; Kassell, Neal F.

2014-01-01

Magnetic Resonance guided Focused Ultrasound Surgery (MRgFUS) represents a novel combination of technologies that is actively being realized as a non-invasive therapeutic tool for a myriad of conditions. These applications are reviewed with a focus on neurological utilization. A combined search of Pubmed and Medline was performed to identify the key events and current status of MRgFUS, with a focus on neurological applications. MRgFUS signifies a potentially ideal device for the treatment of neurological diseases. As it is nearly real-time, it allows monitored provision of treatment location and energy deposition, is noninvasive, thereby limiting or eliminating disruption of normal tissue, provides focal delivery of therapeutic agents, enhances radiation delivery, and permits modulation of neural function. Multiple clinical applications are currently in clinical use and many more are under active preclinical investigation. The therapeutic potential of MRgFUS is expanding rapidly. Although clinically in its infancy, preclinical and early phase I clinical trials in neurosurgery suggest a promising future for MRgFUS. Further investigation is necessary to define its true potential and impact. PMID:22791029

Land-use and land-cover scenarios and spatial modeling at the regional scale

USGS Publications Warehouse

Sohl, Terry L.; Sleeter, Benjamin M.

2012-01-01

Land-use and land-cover (LULC) change has altered a large part of the earth's surface. Scenarios of potential future LULC change are required in order to better manage potential impacts on biodiversity, carbon fluxes, climate change, hydrology, and many other ecological processes. The U.S. Geological Survey is analyzing potential future LULC change in the United States, using an approach based on scenario construction and spatially explicit modeling. Similar modeling techniques are being used to produce historical LULC maps from 1940 to present. With the combination of backcast and forecast LULC data, the USGS is providing consistent LULC data for historical, current, and future time frames to support a variety of research applications.

Application of the coastal generalized ecosystem model (CGEM) to assess the impacts of a potential future climate scenario on northern Gulf of Mexico hypoxia

EPA Science Inventory

Mechanistic hypoxia models for the northern Gulf of Mexico are being used to guide policy goals for Mississippi River nutrient loading reductions. However, to date, these models have not examined the effects of both nutrient loads and future climate. Here, we simulate a future c...

Microbial Cellulases and Their Industrial Applications

PubMed Central

Kuhad, Ramesh Chander; Gupta, Rishi; Singh, Ajay

2011-01-01

Microbial cellulases have shown their potential application in various industries including pulp and paper, textile, laundry, biofuel production, food and feed industry, brewing, and agriculture. Due to the complexity of enzyme system and immense industrial potential, cellulases have been a potential candidate for research by both the academic and industrial research groups. Nowadays, significant attentions have been devoted to the current knowledge of cellulase production and the challenges in cellulase research especially in the direction of improving the process economics of various industries. Scientific and technological developments and the future prospects for application of cellulases in different industries are discussed in this paper. PMID:21912738

Digital video applications in radiologic education: theory, technique, and applications.

PubMed

Hennessey, J G; Fishman, E K; Ney, D R

1994-05-01

Computer-assisted instruction (CAI) has great potential in medical education. The recent explosion of multimedia platforms provides an environment for the seemless integration of text, images, and sound into a single program. This article discusses the role of digital video in the current educational environment as well as its future potential. An indepth review of the technical decisions of this new technology is also presented.

MIPs as Tools in Environmental Biotechnology.

PubMed

Mattiasson, Bo

2015-01-01

Molecular imprints are potentially fantastic constructions. They are selective, robust, and nonbiodegradable if produced from stable polymers. A range of different applications has been presented, everything from separation of enantiomers, via adsorbents for sample preparation before analysis to applications in wastewater treatment. This chapter deals with molecularly imprinted polymers (MIPs) as tools in environmental biotechnology, a field that has the potential to become very important in the future.

Purification of Logic-Qubit Entanglement

PubMed Central

Zhou, Lan; Sheng, Yu-Bo

2016-01-01

Recently, the logic-qubit entanglement shows its potential application in future quantum communication and quantum network. However, the entanglement will suffer from the noise and decoherence. In this paper, we will investigate the first entanglement purification protocol for logic-qubit entanglement. We show that both the bit-flip error and phase-flip error in logic-qubit entanglement can be well purified. Moreover, the bit-flip error in physical-qubit entanglement can be completely corrected. The phase-flip in physical-qubit entanglement error equals to the bit-flip error in logic-qubit entanglement, which can also be purified. This entanglement purification protocol may provide some potential applications in future quantum communication and quantum network. PMID:27377165

Mobile user interface development for the Virginia Connected Corridors.

DOT National Transportation Integrated Search

2016-10-15

The purpose of this research and development activity was to build a mobile application with a low-distraction user interface appropriate for use in a connected vehicle (CV) environment. To realize their full potential, future CV applications will in...

A fault-tolerant multiprocessor architecture for aircraft, volume 1. [autopilot configuration

NASA Technical Reports Server (NTRS)

Smith, T. B.; Hopkins, A. L.; Taylor, W.; Ausrotas, R. A.; Lala, J. H.; Hanley, L. D.; Martin, J. H.

1978-01-01

A fault-tolerant multiprocessor architecture is reported. This architecture, together with a comprehensive information system architecture, has important potential for future aircraft applications. A preliminary definition and assessment of a suitable multiprocessor architecture for such applications is developed.

Mind Reading and Writing: The Future of Neurotechnology.

PubMed

Roelfsema, Pieter R; Denys, Damiaan; Klink, P Christiaan

2018-05-02

Recent advances in neuroscience and technology have made it possible to record from large assemblies of neurons and to decode their activity to extract information. At the same time, available methods to stimulate the brain and influence ongoing processing are also rapidly expanding. These developments pave the way for advanced neurotechnological applications that directly read from, and write to, the human brain. While such technologies are still primarily used in restricted therapeutic contexts, this may change in the future once their performance has improved and they become more widely applicable. Here, we provide an overview of methods to interface with the brain, speculate about potential applications, and discuss important issues associated with a neurotechnologically assisted future. Copyright © 2018 Elsevier Ltd. All rights reserved.

Air cushion landing gear applications study

NASA Technical Reports Server (NTRS)

Earl, T. D.

1979-01-01

A series of air cushion landing gear (ACLG) applications was studied and potential benefits analyzed in order to identify the most attractive of these. The selected applications are new integrated designs (not retrofits) and employ a modified design approach with improved characteristics and performance. To aid the study, a survey of potential users was made. Applications were evaluated in the light of comments received. A technology scenario is developed, with discussion of problem areas, current technology level and future needs. Feasible development timetables are suggested. It is concluded that near-term development of small-size ACLG trunks, exploration of flight effects and braking are key items. The most attractive applications are amphibious with very large cargo aircraft and small general aviation having the greatest potential.

Evaluation of advanced propulsion options for the next manned transportation system: Propulsion evolution study

NASA Technical Reports Server (NTRS)

Spears, L. T.; Kramer, R. D.

1990-01-01

The objectives were to examine launch vehicle applications and propulsion requirements for potential future manned space transportation systems and to support planning toward the evolution of Space Shuttle Main Engine (SSME) and Space Transportation Main Engine (STME) engines beyond their current or initial launch vehicle applications. As a basis for examinations of potential future manned launch vehicle applications, we used three classes of manned space transportation concepts currently under study: Space Transportation System Evolution, Personal Launch System (PLS), and Advanced Manned Launch System (AMLS). Tasks included studies of launch vehicle applications and requirements for hydrogen-oxygen rocket engines; the development of suggestions for STME engine evolution beyond the mid-1990's; the development of suggestions for STME evolution beyond the Advanced Launch System (ALS) application; the study of booster propulsion options, including LOX-Hydrocarbon options; the analysis of the prospects and requirements for utilization of a single engine configuration over the full range of vehicle applications, including manned vehicles plus ALS and Shuttle C; and a brief review of on-going and planned LOX-Hydrogen propulsion technology activities.

Advanced Life Support Systems: Opportunities for Technology Transfer

NASA Technical Reports Server (NTRS)

Fields, B.; Henninger, D.; Ming, D.; Verostko, C. E.

1994-01-01

NASA's future missions to explore the solar system will be of long-duration possibly lasting years at a time. Human life support systems will have to operate with very high reliability for these long periods with essentially no resupply from Earth. Such life support systems will make extensive use of higher plants, microorganisms, and physicochemical processes for recycling air and water, processing wastes, and producing food. Development of regenerative life support systems will be a pivotal capability for NASA's future human missions. A fully functional closed loop human life support system currently does not exist and thus represents a major technical challenge for space exploration. Technologies where all life support consumables are recycled have many potential terrestrial applications as well. Potential applications include providing human habitation in hostile environments such as the polar regions or the desert in such a way as to minimize energy expenditures and to minimize negative impacts on those often ecologically-sensitive areas. Other potential applications include production of food and ornamental crops without damaging the environment from fertilizers that contaminate water supplies; removal of trace gas contaminants from tightly sealed, energy-efficient buildings (the so-called sick building syndrome); and even the potential of gaining insight into the dynamics of the Earth's biosphere such that we can better manage our global environment. Two specific advanced life support technologies being developed by NASA, with potential terrestrial application, are the zeoponic plant growth system and the Hybrid Regenerative Water Recovery System (HRWRS). The potential applications for these candidate dual use technologies are quite different as are the mechanisms for transfer. In the case of zeoponics, a variety of commercial applications has been suggested which represent potentially lucrative markets. Also, the patented nature of this product offers opportunities for licensing to commercial entities. In the case of the HRWRS, commercial markets with broad applications have not been identified but some terrestrial applications are being explored where this approach has advantages over other methods of waste water processing. Although these potential applications do not appear to have the same broad attraction from the standpoint of rapid commercialization, they represent niches where commercialization possibilities as well as social benefits could be realized.

An Overview of Algae Biofuel Production and Potential Environmental Impact

EPA Science Inventory

Algae are among the most potentially significant sources of sustainable biofuels in the future of renewable energy. A feedstock with virtually unlimited applicability, algae can metabolize various waste streams (e.g., municipal wastewater, carbon dioxide from industrial flue gas)...

Future of synthetic aperture radar

NASA Technical Reports Server (NTRS)

Barath, F. T.

1978-01-01

The present status of the applications of Synthetic Aperture Radars (SARs) is reviewed, and the technology state-of-the art as represented by the Seasat-A and SIR-A SARs examined. The potential of SAR applications, and the near- and longer-term technology trends are assessed.

MAGNESIUM ALLOYS IN US MILITARY APPLICATIONS: PAST, CURRENT AND FUTURE SOLUTIONS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mathaudhu, Suveen N.; Nyberg, Eric A.

2010-02-26

Since the 1940’s Mg-alloys have been used for military applications, from aircraft components to ground vehicles. The drive for usage was primarily availability and lightweighting of military systems. But the promise of widespread military usage was not met largely based on corrosion and flammability concerns, poor mechanical behavior and inferior ballistic response. This review paper will cover historical, current and potential future applications with a focus on scientific, engineering and social barriers relevant to integration of Mg-alloy. It will also present mechanical and physical property improvements solutions which are currently being developed to address these issues.

Space qualification of silicon carbide for mirror applications: progress and future objectives

NASA Astrophysics Data System (ADS)

Palusinski, Iwona A.; Ghozeil, Isaac

2006-09-01

Production of optical silicon carbide (SiC) for mirror applications continues to evolve and there are renewed plans to use this material in future space-based systems. While SiC has the potential for rapid and cost-effective manufacturing of large, lightweight, athermal optical systems, this material's use in mirror applications is relatively new and has limited flight heritage. This combination of drivers stresses the necessity for a space qualification program for this material. Successful space qualification will require independent collaboration to absorb the high cost of executing this program while taking advantage of each contributing group's laboratory expertise to develop a comprehensive SiC database. This paper provides an overview of the trends and progress in the production of SiC, and identifies future objectives such as non-destructive evaluation and space-effects modeling to ensure proper implementation of this material into future space-based systems.

Induced pluripotent stem cells in hematology: current and future applications

PubMed Central

Focosi, D; Amabile, G; Di Ruscio, A; Quaranta, P; Tenen, D G; Pistello, M

2014-01-01

Reprogramming somatic cells into induced pluripotent stem (iPS) cells is nowadays approaching effectiveness and clinical grade. Potential uses of this technology include predictive toxicology, drug screening, pathogenetic studies and transplantation. Here, we review the basis of current iPS cell technology and potential applications in hematology, ranging from disease modeling of congenital and acquired hemopathies to hematopoietic stem and other blood cell transplantation. PMID:24813079

Diffusion Weighted/Tensor Imaging, Functional MRI and Perfusion Weighted Imaging in Glioblastoma-Foundations and Future.

PubMed

Salama, Gayle R; Heier, Linda A; Patel, Praneil; Ramakrishna, Rohan; Magge, Rajiv; Tsiouris, Apostolos John

2017-01-01

In this article, we review the basics of diffusion tensor imaging and functional MRI, their current utility in preoperative neurosurgical mapping, and their limitations. We also discuss potential future applications, including implementation of resting state functional MRI. We then discuss perfusion and diffusion-weighted imaging and their application in advanced neuro-oncologic practice. We explain how these modalities can be helpful in guiding surgical biopsies and differentiating recurrent tumor from treatment related changes.

Diffusion Weighted/Tensor Imaging, Functional MRI and Perfusion Weighted Imaging in Glioblastoma—Foundations and Future

PubMed Central

Salama, Gayle R.; Heier, Linda A.; Patel, Praneil; Ramakrishna, Rohan; Magge, Rajiv; Tsiouris, Apostolos John

2018-01-01

In this article, we review the basics of diffusion tensor imaging and functional MRI, their current utility in preoperative neurosurgical mapping, and their limitations. We also discuss potential future applications, including implementation of resting state functional MRI. We then discuss perfusion and diffusion-weighted imaging and their application in advanced neuro-oncologic practice. We explain how these modalities can be helpful in guiding surgical biopsies and differentiating recurrent tumor from treatment related changes. PMID:29403420

Present and future medical applications of microbial exopolysaccharides

PubMed Central

Moscovici, Misu

2015-01-01

Microbial exopolysaccharides (EPS) have found outstanding medical applications since the mid-20th century, with the first clinical trials on dextran solutions as plasma expanders. Other EPS entered medicine firstly as conventional pharmaceutical excipients (e.g., xanthan – as suspension stabilizer, or pullulan – in capsules and oral care products). Polysaccharides, initially obtained from plant or animal sources, became easily available for a wide range of applications, especially when they were commercially produced by microbial fermentation. Alginates are used as anti-reflux, dental impressions, or as matrix for tablets. Hyaluronic acid and derivatives are used in surgery, arthritis treatment, or wound healing. Bacterial cellulose is applied in wound dressings or scaffolds for tissue engineering. The development of drug controlled-release systems and of micro- and nanoparticulated ones, has opened a new era of medical applications for biopolymers. EPS and their derivatives are well-suited potentially non-toxic, biodegradable drug carriers. Such systems concern rating and targeting of controlled release. Their large area of applications is explained by the available manifold series of derivatives, whose useful properties can be thereby controlled. From matrix inclusion to conjugates, different systems have been designed to solubilize, and to assure stable transport in the body, target accumulation and variable rate-release of a drug substance. From controlled drug delivery, EPS potential applications expanded to vaccine adjuvants and diagnostic imaging systems. Other potential applications are related to the bioactive (immunomodulator, antitumor, antiviral) characteristics of EPS. The numerous potential applications still wait to be developed into commercial pharmaceuticals and medical devices. Based on previous and recent results in important medical-pharmaceutical domains, one can undoubtedly state that EPS medical applications have a broad future ahead. PMID:26483763

mTOR Inhibitors in Children: Current Indications and Future Directions in Neurology.

PubMed

Jeong, Anna; Wong, Michael

2016-12-01

The mammalian/mechanistic target of rapamycin (mTOR) pathway is a key signaling pathway that has been implicated in genetic epilepsy syndromes, neurodegenerative diseases, and conditions associated with autism spectrum disorder and cognitive impairment. The mTOR pathway has become an exciting treatment target for these various disorders, with mTOR inhibitors such as rapamycin being studied for their potential therapeutic applications. In particular, tuberous sclerosis complex (TSC) is a genetic disorder resulting from overactivation of the mTOR pathway, and pharmacologic therapy with mTOR inhibitors has emerged as a viable treatment option for the systemic manifestations of the disease. In this review, we discuss the approved indications for mTOR inhibitors in TSC, the potential future applications of mTOR inhibitors in TSC and other neurological conditions, and the safety considerations applicable to mTOR therapy in the pediatric population.

The future is 'ambient'

NASA Astrophysics Data System (ADS)

Lugmayr, Artur

2006-02-01

The research field of ambient media starts to spread rapidly and first applications for consumer homes are on the way. Ambient media is the logical continuation of research around media. Media has been evolving from old media (e.g. print media), to integrated presentation in one form (multimedia - or new media), to generating a synthetic world (virtual reality), to the natural environment is the user-interface (ambient media), and will be evolving towards real/synthetic undistinguishable media (bio-media or bio-multimedia). After the IT bubble was bursting, multimedia was lacking a vision of potential future scenarios and applications. Within this research paper the potentials, applications, and market available solutions of mobile ambient multimedia are studied. The different features of ambient mobile multimedia are manifold and include wearable computers, adaptive software, context awareness, ubiquitous computers, middleware, and wireless networks. The paper especially focuses on algorithms and methods that can be utilized to realize modern mobile ambient systems.

Programming research: where are we and where do we go from here?

PubMed

Koletzko, Berthold; Symonds, Michael E; Olsen, Sjurdur F

2011-12-01

Convincing evidence has accumulated to show that both pre- and postnatal nutrition preprogram long-term health, well-being, and performance until adulthood and old age. There is a very large potential in the application of this knowledge to promote public health. One of the prerequisites for translational application is to strengthen the scientific evidence. More extensive knowledge is needed (eg, on effect sizes of early life programming in contemporary populations, on specific nutritional exposures, on sensitive time periods in early life, on precise underlying mechanisms, and on potential effect differences in subgroups characterized by, eg, genetic predisposition or sex). Future programming research should aim at filling the existing gaps in scientific knowledge, consider the entire lifespan, address socioeconomic issues, and foster innovation. Research should aim at results suitable for translational application (eg, by leading to health-promoting policies and evidence-based dietary recommendations in the perinatal period). International collaboration and a close research partnership of academia, industry, and small and medium enterprises may strengthen research and innovative potential enhancing the likelihood of translational application. The scientific know-how and methodology available today allow us to take major steps forward in the near future; hence, research on nutritional programming deserves high priority.

Photovoltaics as a terrestrial energy source. Volume 1: An introduction

NASA Technical Reports Server (NTRS)

Smith, J. L.

1980-01-01

Photovoltaic (PV) systems were examined their potential for terrestrial application and future development. Photovoltaic technology, existing and potential photovoltaic applications, and the National Photovoltaics Program are reviewed. The competitive environment for this electrical source, affected by the presence or absence of utility supplied power is evaluated in term of systems prices. The roles of technological breakthroughs, directed research and technology development, learning curves, and commercial demonstrations in the National Program are discussed. The potential for photovoltaics to displace oil consumption is examined, as are the potential benefits of employing PV in either central-station or non-utility owned, small, distributed systems.

Examination of Frameworks for Safe Integration of Intelligent Small UAS into the NAS

NASA Technical Reports Server (NTRS)

Logan, Michael J.

2012-01-01

This paper discusses a proposed framework for the safe integration of small unmanned aerial systems (sUAS) into the National Airspace System (NAS). The paper briefly examines the potential uses of sUAS to build an understanding of the location and frequency of potential future flight operations based on the future applications of the sUAS systems. The paper then examines the types of systems that would be required to meet the application-level demand to determine "classes" of platforms and operations. A framework for categorization of the "intelligence" level of the UAS is postulated for purposes of NAS integration. Finally, constraints on the intelligent systems are postulated to ensure their ease of integration into the NAS.

Telerehabilitation robotics: bright lights, big future?

PubMed

Carignan, Craig R; Krebs, Hermano I

2006-01-01

The potential for remote diagnosis and treatment over the Internet using robotics is now a reality. The state of the art is exemplified by several Internet applications, and we explore the current trends in developing new systems. We review the technical challenges that lie ahead, along with some potential solutions. Some promising results for a new bilateral system involving two InMotion2 robots are presented. Finally, we discuss the future direction and commercial outlook for rehabilitation robots over the next 15 years.

76 FR 23198 - Segregation of Lands-Renewable Energy

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-26

... could be used to carry the power generated from a specific wind or solar energy ROW project, and the... included in a pending or future wind or solar energy generation right- of-way (ROW) application, or public lands identified by the BLM for a potential future wind or solar energy generation ROW authorization...

The Future of Virtual Reality in the Classroom

ERIC Educational Resources Information Center

Vance, Amelia

2016-01-01

As state boards of education and other state policymakers consider the future of schools, sorting fad technology from technology that accelerates learning is key. Virtual reality (VR) is one such technology with promise that seems unlikely to fizzle. Hailed as potentially transformative for education and still in the early stages of application,…

Engineering stem cells for future medicine.

PubMed

Ricotti, Leonardo; Menciassi, Arianna

2013-03-01

Despite their great potential in regenerative medicine applications, stem cells (especially pluripotent ones) currently show a limited clinical success, partly due to a lack of biological knowledge, but also due to a lack of specific and advanced technological instruments able to overcome the current boundaries of stem cell functional maturation and safe/effective therapeutic delivery. This paper aims at describing recent insights, current limitations, and future horizons related to therapeutic stem cells, by analyzing the potential of different bioengineering disciplines in bringing stem cells toward a safe clinical use. First, we clarify how and why stem cells should be properly engineered and which could be in a near future the challenges and the benefits connected with this process. Second, we identify different routes toward stem cell differentiation and functional maturation, relying on chemical, mechanical, topographical, and direct/indirect physical stimulation. Third, we highlight how multiscale modeling could strongly support and optimize stem cell engineering. Finally, we focus on future robotic tools that could provide an added value to the extent of translating basic biological knowledge into clinical applications, by developing ad hoc enabling technologies for stem cell delivery and control.

Future sensor system needs for staring arrays

NASA Astrophysics Data System (ADS)

Miller, John Lester

2011-05-01

This is a systems application paper regarding how sensor systems may use future technology FPAs. A historical perspective is discussed along with lessons learned from previous technologies. Future system requirements for strained super-lattice (SLS), quantum dots (QDOT) and traditional quantum well infrared photo-diodes (QWIP) arrays will be presented from both a commercial and military perspective. New potential markets will open up in the future if certain FPA technologies can reduce cost and provide higher sensitivities at higher operating temperatures.

Global-local methodologies and their application to nonlinear analysis

NASA Technical Reports Server (NTRS)

Noor, Ahmed K.

1989-01-01

An assessment is made of the potential of different global-local analysis strategies for predicting the nonlinear and postbuckling responses of structures. Two postbuckling problems of composite panels are used as benchmarks and the application of different global-local methodologies to these benchmarks is outlined. The key elements of each of the global-local strategies are discussed and future research areas needed to realize the full potential of global-local methodologies are identified.

An Overview of Algae Biofuel Production and Potential Environmental Impact (Journal Article)

EPA Science Inventory

Algae are one of the most potentially significant sources of biofuels in the future of renewable energy. A feedstock with almost unlimited applicability, algae can metabolize various waste streams (such as municipal wastewater, and carbon dioxide from power generation) and produc...

Challenges of future aircraft propulsion: A review of distributed propulsion technology and its potential application for the all electric commercial aircraft

NASA Astrophysics Data System (ADS)

Gohardani, Amir S.; Doulgeris, Georgios; Singh, Riti

2011-07-01

This paper highlights the role of distributed propulsion technology for future commercial aircraft. After an initial historical perspective on the conceptual aspects of distributed propulsion technology and a glimpse at numerous aircraft that have taken distributed propulsion technology to flight, the focal point of the review is shifted towards a potential role this technology may entail for future commercial aircraft. Technological limitations and challenges of this specific technology are also considered in combination with an all electric aircraft concept, as means of predicting the challenges associated with the design process of a next generation commercial aircraft.

Breast magnetic resonance elastography: a review of clinical work and future perspectives.

PubMed

Bohte, A E; Nelissen, J L; Runge, J H; Holub, O; Lambert, S A; de Graaf, L; Kolkman, S; van der Meij, S; Stoker, J; Strijkers, G J; Nederveen, A J; Sinkus, R

2018-05-30

This review on magnetic resonance elastography (MRE) of the breast provides an overview of available literature and describes current developments in the field of breast MRE, including new transducer technology for data acquisition and multi-frequency-derived power-law behaviour of tissue. Moreover, we discuss the future potential of breast MRE, which goes beyond its original application as an additional tool in differentiating benign from malignant breast lesions. These areas of ongoing and future research include MRE for pre-operative tumour delineation, staging, monitoring and predicting response to treatment, as well as prediction of the metastatic potential of primary tumours. Copyright © 2018 John Wiley & Sons, Ltd.

Hydrogel Biomaterials: A Smart Future?

PubMed Central

Kopeček, Jindřich

2007-01-01

Hydrogels were the first biomaterials developed for human use. The state-of-the-art and potential for the future are discussed. Recently, new designs have produced mechanically strong synthetic hydrogels. Protein based hydrogels and hybrid hydrogels containing protein domains present a novel advance; such biomaterials may self-assemble from block or graft copolymers containing biorecognition domains. One of the domains, the coiled-coil, ubiquitously found in nature, has been used as an example to demonstrate the developments in the design of smart hydrogels. The application potential of synthetic, protein-based, DNA-based, and hybrid hydrogels bodes well for the future of this class of biomaterials. PMID:17697712

A Selected Bibliography of On-Line Visual Displays and Their Applications.

ERIC Educational Resources Information Center

Braidwood, J.

Contained in this bibliography are 312 references as they related to general principles and problems of information display, man-computer interaction, present and possible future display equipment, ergonomic aspects of display design, and current and potential applications, especially to information processing. (Author/MM)

DEVELOPMENT OF CFD SIMULATION APPLICATIONS FOR LOCAL-SCALE AREAS AND POTENTIAL INTERFACE WITH MESOSCALE MODELS

EPA Science Inventory

The presentation summarizes developments of ongoing applications of fine-scale (geometry specific) CFD simulations to urban areas within atmospheric boundary layers. Enabling technology today and challenges for the future are discussed. There is a challenging need to develop a ...

Carbon-nanotube-based liquids: a new class of nanomaterials and their applications

NASA Astrophysics Data System (ADS)

Phan, Ngoc Minh; Thang Bui, Hung; Nguyen, Manh Hong; Khoi Phan, Hong

2014-03-01

Carbon-nanotube-based liquids—a new class of nanomaterials—have shown many interesting properties and distinctive features offering unprecedented potential for many applications. This paper summarizes the recent progress on the study of the preparation, characterization and properties of carbon-nanotube-based liquids including so-called nanofluids, nanolubricants and different kinds of nanosolutions containing multi-walled carbon nanotubes/single-walled carbon nanotubes/graphene. A broad range of current and future applications of these nanomaterials in the fields of energy saving, power electronic and optoelectronic devices, biotechnology and agriculture are presented. The paper also identifies challenges and opportunities for future research.

Multiscale Modeling, Simulation and Visualization and Their Potential for Future Aerospace Systems

NASA Technical Reports Server (NTRS)

Noor, Ahmed K. (Compiler)

2002-01-01

This document contains the proceedings of the Training Workshop on Multiscale Modeling, Simulation and Visualization and Their Potential for Future Aerospace Systems held at NASA Langley Research Center, Hampton, Virginia, March 5 - 6, 2002. The workshop was jointly sponsored by Old Dominion University's Center for Advanced Engineering Environments and NASA. Workshop attendees were from NASA, other government agencies, industry, and universities. The objectives of the workshop were to give overviews of the diverse activities in hierarchical approach to material modeling from continuum to atomistics; applications of multiscale modeling to advanced and improved material synthesis; defects, dislocations, and material deformation; fracture and friction; thin-film growth; characterization at nano and micro scales; and, verification and validation of numerical simulations, and to identify their potential for future aerospace systems.

Development of XUV projection lithography at 60 to 80 nm

NASA Astrophysics Data System (ADS)

Newnam, B. E.; Viswanathan, V. K.

The rationale, design, component properties, properties, and potential capabilities of extreme-ultraviolet (XUV) projection lithography systems using 60-80 nm illumination and single-surface reflectors are described. These systems are evaluated for potential application to high-volume production of future generations of gigabit chips.

Development of XUV projection lithography at 60-80 nm (Poster Paper)

NASA Astrophysics Data System (ADS)

Newnam, Brian E.; Viswanathan, Vriddhachalam K.

1992-07-01

The rationale, design, component properties, and potential capabilities of extreme-ultraviolet (XUV) projection lithography systems using 60 - 80 nm illumination and single-surface reflectors are described. These systems are evaluated for potential application to high-volume production of future generations of gigabit chips.

24 CFR 886.101 - Applicability.

Code of Federal Regulations, 2010 CFR

2010-04-01

... potentially serious financial problems which, on the basis of financial and/or management analysis, appear to... potentially serious financial difficulties. A first priority should be given to projects with presently serious financial problems, which are likely to result in a claim on the insurance fund in the near future...

24 CFR 886.101 - Applicability.

Code of Federal Regulations, 2011 CFR

2011-04-01

... potentially serious financial problems which, on the basis of financial and/or management analysis, appear to... potentially serious financial difficulties. A first priority should be given to projects with presently serious financial problems, which are likely to result in a claim on the insurance fund in the near future...

Evidence That International Undergraduates Can Succeed Academically Despite Struggling with English

ERIC Educational Resources Information Center

Fass-Holmes, Barry; Vaughn, Allison A.

2015-01-01

Many American universities require international applicants whose native language is not English to submit English proficiency exam scores presumably because of proficiency's potential to predict future academic success. The present study provides evidence, however, that such applicants can succeed academically despite struggling with English.…

Conference on Charge-Coupled Device Technology and Applications

NASA Technical Reports Server (NTRS)

1976-01-01

Papers were presented from the conference on charge coupled device technology and applications. The following topics were investigated: data processing; infrared; devices and testing; electron-in, x-ray, radiation; and applications. The emphasis was on the advances of mutual relevance and potential significance both to industry and NASA's current and future requirements in all fields of imaging, signal processing and memory.

Biosurfactants: Promising Molecules for Petroleum Biotechnology Advances.

PubMed

De Almeida, Darne G; Soares Da Silva, Rita de Cássia F; Luna, Juliana M; Rufino, Raquel D; Santos, Valdemir A; Banat, Ibrahim M; Sarubbo, Leonie A

2016-01-01

The growing global demand for sustainable technologies that improves the efficiency of petrochemical processes in the oil industry has driven advances in petroleum biotechnology in recent years. Petroleum industry uses substantial amounts of petrochemical-based synthetic surfactants in its activities as mobilizing agents to increase the availability or recovery of hydrocarbons as well as many other applications related to extraction, treatment, cleaning, and transportation. However, biosurfactants have several potential applications for use across the oil processing chain and in the formulations of petrochemical products such as emulsifying/demulsifying agents, anticorrosive, biocides for sulfate-reducing bacteria, fuel formulation, extraction of bitumen from tar sands, and many other innovative applications. Due to their versatility and proven efficiency, biosurfactants are often presented as valuable versatile tools that can transform and modernize petroleum biotechnology in an attempt to provide a true picture of state of the art and directions or use in the oil industry. We believe that biosurfactants are going to have a significant role in many future applications in the oil industries and in this review therefore, we highlight recent important relevant applications, patents disclosures and potential future applications for biosurfactants in petroleum and related industries.

Biosurfactants: Promising Molecules for Petroleum Biotechnology Advances

PubMed Central

De Almeida, Darne G.; Soares Da Silva, Rita de Cássia F.; Luna, Juliana M.; Rufino, Raquel D.; Santos, Valdemir A.; Banat, Ibrahim M.; Sarubbo, Leonie A.

2016-01-01

The growing global demand for sustainable technologies that improves the efficiency of petrochemical processes in the oil industry has driven advances in petroleum biotechnology in recent years. Petroleum industry uses substantial amounts of petrochemical-based synthetic surfactants in its activities as mobilizing agents to increase the availability or recovery of hydrocarbons as well as many other applications related to extraction, treatment, cleaning, and transportation. However, biosurfactants have several potential applications for use across the oil processing chain and in the formulations of petrochemical products such as emulsifying/demulsifying agents, anticorrosive, biocides for sulfate-reducing bacteria, fuel formulation, extraction of bitumen from tar sands, and many other innovative applications. Due to their versatility and proven efficiency, biosurfactants are often presented as valuable versatile tools that can transform and modernize petroleum biotechnology in an attempt to provide a true picture of state of the art and directions or use in the oil industry. We believe that biosurfactants are going to have a significant role in many future applications in the oil industries and in this review therefore, we highlight recent important relevant applications, patents disclosures and potential future applications for biosurfactants in petroleum and related industries. PMID:27843439

Power systems for future missions

NASA Technical Reports Server (NTRS)

Gill, S. P.; Frye, P. E.; Littman, Franklin D.; Meisl, C. J.

1994-01-01

A comprehensive scenario of future missions was developed and applicability of different power technologies to these missions was assessed. Detailed technology development roadmaps for selected power technologies were generated. A simple methodology to evaluate economic benefits of current and future power system technologies by comparing Life Cycle Costs of potential missions was developed. The methodology was demonstrated by comparing Life Cycle Costs for different implementation strategies of DIPS/CBC technology to a selected set of missions.

Advances in the application of MRI to amyotrophic lateral sclerosis

PubMed Central

Turner, Martin R; Modo, Michel

2011-01-01

Importance of the field With the emergence of therapeutic candidates for the incurable and rapidly progressive neurodegenerative condition of amyotrophic lateral sclerosis (ALS), it will be essential to develop easily obtainable biomarkers for diagnosis, as well as monitoring, in a disease where clinical examination remains the predominant diagnostic tool. Magnetic resonance imaging (MRI) has greatly developed over the past thirty years since its initial introduction to neuroscience. With multi-modal applications, MRI is now offering exciting opportunities to develop practical biomarkers in ALS. Areas covered in this review The historical application of MRI to the field of ALS, its state-of-the-art and future aspirations will be reviewed. Specifically, the significance and limitations of structural MRI to detect gross morphological tissue changes in relation to clinical presentation will be discussed. The more recent application of diffusion tensor imaging (DTI), magnetic resonance spectroscopy (MRS), functional and resting-state MRI (fMRI & R-fMRI) will be contrasted in relation to these more conventional MRI assessments. Finally, future aspirations will be sketched out in providing a more disease mechanism-based molecular MRI. What the reader will gain This review will equip the reader with an overview of the application of MRI to ALS and illustrate its potential to develop biomarkers. This discussion is exemplified by key studies, demonstrating the strengths and limitations of each modality. The reader will gain an expert opinion on both the current and future developments of MR imaging in ALS. Take home message MR imaging generates potential diagnostic, prognostic and therapeutic monitoring biomarkers of ALS. The emerging fusion of structural, functional and potentially molecular imaging will improve our understanding of wider cerebral connectivity and holds the promise of biomarkers sensitive to the earliest changes. PMID:21516259

Magnus effect: An overview of its past and future practical applications, 1850-1985, volumes 1 and 2

NASA Astrophysics Data System (ADS)

Borg, J.

The report is in two volumes and is intended to present the known data and past and future applications of Magnus effect devices. (Magnus effect devices are very high lift devices which can be used in applications where airfoils are currently used.) This first volume includes the history of Magnus effect devices, theory and principles, a significant patent review, practical marine applications, formulas and experimental data, comparisons of Magnus effect and other state-of-the-art devices, identification of further testing needed, and a proposed test program. Appendices include rudder research and a literature critique. The second volume is a collection of the drawings for 39 magnus effect patents plus a critique of each patent evaluating its potential, especially for marine applications.

Study terrestrial applications of solar cell powered systems

NASA Technical Reports Server (NTRS)

Ravin, J. W.

1973-01-01

Terrestrial applications of solar cells and design systems are considered for those applications that show the most promise for becoming practical and accepted by users within the next five years. The study includes the definition, categorization, evaluation and screening of the most attractive potential terrestrial applications for solar cells. Potential markets are initially grouped and categorized in a general sense and are weighted in priority by their business volume, present and future. From a categorized list including marine, transportation, security, communication, meteorological and others, 66 potential solar cell applications have been cataloged. A methodology was formulated to include the criteria for evaluation and screening. The evaluation process covers all parts and components of the complete system required for each application and gives consideration to all factors, such as engineering, economic, production, marketing and other factors that may have an influence on the acceptance of the system.

Recent Progress of Microfluidics in Translational Applications

PubMed Central

Liu, Zongbin; Han, Xin

2016-01-01

Microfluidics, featuring microfabricated structures, is a technology for manipulating fluids at the micrometer scale. The small dimension and flexibility of microfluidic systems are ideal for mimicking molecular and cellular microenvironment, and show great potential in translational research and development. Here, the recent progress of microfluidics in biological and biomedical applications, including molecular analysis, cellular analysis, and chip-based material delivery and biomimetic design is presented. The potential future developments in the translational microfluidics field are also discussed. PMID:27091777

Global-local methodologies and their application to nonlinear analysis. [for structural postbuckling study

NASA Technical Reports Server (NTRS)

Noor, Ahmed K.

1986-01-01

An assessment is made of the potential of different global-local analysis strategies for predicting the nonlinear and postbuckling responses of structures. Two postbuckling problems of composite panels are used as benchmarks and the application of different global-local methodologies to these benchmarks is outlined. The key elements of each of the global-local strategies are discussed and future research areas needed to realize the full potential of global-local methodologies are identified.

Perspectives on energy storage wheels for space station application

NASA Technical Reports Server (NTRS)

Oglevie, R. E.

1984-01-01

Several of the issues of the workshop are addressed from the perspective of a potential Space Station developer and energy wheel user. Systems' considerations are emphasized rather than component technology. The potential of energy storage wheel (ESW) concept is discussed. The current status of the technology base is described. Justification for advanced technology development is also discussed. The study concludes that energy storage in wheels is an attractive concept for immediate technology development and future Space Station application.

Application of Aptamer-based hybrid molecules in Early Diagnosis and Treatment of Diabetes Mellitus: From the Concepts toward the Future.

PubMed

Ahmadi, Sepideh; Rabiee, Navid; Rabiee, Mohammad

2018-06-06

Aptamers have several positive advantages that made them eminent as a potential factor in diagnosing and treating diseases such as their application in prevention and treatment of diabetes. In this opinion-based mini review article, we aimed to investigate the DNA and RNA-based hybrid molecules specifically aptamers and had a logical conclusion as a promising future prospective in early diagnosis and treatment of diabetes. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

The role of superconductivity in the Space Program: An assessment of present capabilities and future potential

NASA Technical Reports Server (NTRS)

Sullivan, D. B. (Editor)

1978-01-01

Technical subject areas discussed include: (1) high field magnets; (2) magnetometers; (3) digital electronics; (4) high frequency detectors; (5) instruments related to gravitational studies; and (6) ultra high Q cavities. Applications of superconductivity which are of potential interest to NASA were identified.

An instrument thermal data base system. [for future shuttle missions

NASA Technical Reports Server (NTRS)

Bartoszek, J. T.; Csigi, K. I.; Ollendorf, S.; Oberright, J. E.

1981-01-01

The rationale for the implementation of an Instrument Thermal Data Base System (ITDBS) is discussed and the potential application of a data base management system in support of future space missions, the design of scientific instruments needed, and the potential payload groupings is described. Two basic data files are suggested, the first containing a detailed narrative information list pertaining to design configurations and optimum performance of each instrument, and the second consisting of a description of the parameters pertinent to the instruments' thermal control and design in the form of a summary record of coded information, and serving as a recall record. The applicability of a data request sheet for preliminary planning is described and is concluded that the proposed system may additionally prove to be a method of inventory control.

Mesenchymal stem cell therapy in cats: Current knowledge and future potential.

PubMed

Quimby, Jessica M; Borjesson, Dori L

2018-03-01

Practical relevance: Stem cell therapy is an innovative field of scientific investigation with tremendous potential for clinical application in veterinary medicine. Based on the known desirable immunomodulatory properties of mesenchymal stem cells, this therapy holds promise for the treatment of a variety of inflammatory diseases in cats. This review details our current understanding of feline stem cell biology and proposed mechanism of action. Studies performed in feline clinical trials for diseases including gingivostomatitis, chronic enteropathy, asthma and kidney disease are summarized, with the goal of providing an overview of the current status of this treatment modality and its potential for the future.

Pursuing the unlimited potential of microorganisms-progress and prospect of a fermentation company.

PubMed

Arisawa, Akira; Watanabe, Azuma

2017-01-01

Production of pharmaceuticals and chemicals using microbial functions has bestowed numerous benefits onto society. The Nobel Prize awarded to Professor Ōmura, Distinguished Emeritus Professor of Kitasato University, showed the world the importance of the discovery and practical application of microorganisms. Now, increasing attention is turned toward the future path of this field. As people involved in the microorganism industry, we will review the industrial activities thus far and consider the possible future developments in this field and its potential contribution to society.

Fuzzy Set Theory and Medicine: The First Twenty Years and Beyond

PubMed Central

Maiers, Jerald E.

1985-01-01

Fuzzy set theory is a mathematical sub-disipline, initially introduced in 1965. Essentially it was conceived as a formal approach to deal with the imprecision characteristic of real world applications, particularly medical issues. This review summarizes the medical applications of fuzzy set theory to date; assesses the value of fuzzy sets in medical applications; and suggests future potential for such an approach.

Military applications of automatic speech recognition and future requirements

NASA Technical Reports Server (NTRS)

Beek, Bruno; Cupples, Edward J.

1977-01-01

An updated summary of the state-of-the-art of automatic speech recognition and its relevance to military applications is provided. A number of potential systems for military applications are under development. These include: (1) digital narrowband communication systems; (2) automatic speech verification; (3) on-line cartographic processing unit; (4) word recognition for militarized tactical data system; and (5) voice recognition and synthesis for aircraft cockpit.

Technology Needs to Support Future Mars Exploration

NASA Technical Reports Server (NTRS)

Nilsen, Erik N.; Baker, John; Lillard, Randolph P.

2013-01-01

The Mars Program Planning Group (MPPG) under the direction of Dr. Orlando Figueroa, was chartered to develop options for a program-level architecture for robotic exploration of Mars consistent with the objective to send humans to Mars in the 2030's. Scientific pathways were defined for future exploration, and multiple architectural options were developed that meet current science goals and support the future human exploration objectives. Integral to the process was the identification of critical technologies which enable the future scientific and human exploration goals. This paper describes the process for technology capabilities identification and examines the critical capability needs identified in the MPPG process. Several critical enabling technologies that have been identified to support the robotic exploration goals and with potential feedforward application to human exploration goals. Potential roadmaps for the development and validation of these technologies are discussed, including options for subscale technology demonstrations of future human exploration technologies on robotic missions.

Application of advanced technologies to future military transports

NASA Technical Reports Server (NTRS)

Clark, Rodney L.; Lange, Roy H.; Wagner, Richard D.

1990-01-01

Long range military transport technologies are addressed with emphasis of defining the potential benefits of the hybrid laminar flow control (HLFC) concept currently being flight tested. Results of a 1990's global range transport study are presented showing the expected payoff from application of advanced technologies. Technology forecast for military transports is also presented.

Cellular Radio Telecommunication for Health Care: Benefits and Risks

PubMed Central

Sneiderman, Charles A.; Ackerman, Michael J.

2004-01-01

Cellular radio telecommunication has increased exponentially with many applications to health care reported. The authors attempt to summarize published applications with demonstrated effect on health care, review briefly the rapid evolution of hardware and software standards, explain current limitations and future potential of data quality and security, and discuss issues of safety. PMID:15298996

Helper-Dependent Adenoviral Vectors.

PubMed

Rosewell, Amanda; Vetrini, Francesco; Ng, Philip

2011-10-29

Helper-dependent adenoviral vectors are devoid of all viral coding sequences, possess a large cloning capacity, and can efficiently transduce a wide variety of cell types from various species independent of the cell cycle to mediate long-term transgene expression without chronic toxicity. These non-integrating vectors hold tremendous potential for a variety of gene transfer and gene therapy applications. Here, we review the production technologies, applications, obstacles to clinical translation and their potential resolutions, and the future challenges and unanswered questions regarding this promising gene transfer technology.

Helper-Dependent Adenoviral Vectors

PubMed Central

Rosewell, Amanda; Vetrini, Francesco; Ng, Philip

2012-01-01

Helper-dependent adenoviral vectors are devoid of all viral coding sequences, possess a large cloning capacity, and can efficiently transduce a wide variety of cell types from various species independent of the cell cycle to mediate long-term transgene expression without chronic toxicity. These non-integrating vectors hold tremendous potential for a variety of gene transfer and gene therapy applications. Here, we review the production technologies, applications, obstacles to clinical translation and their potential resolutions, and the future challenges and unanswered questions regarding this promising gene transfer technology. PMID:24533227

Recent Progress of Microfluidics in Translational Applications.

PubMed

Liu, Zongbin; Han, Xin; Qin, Lidong

2016-04-20

Microfluidics, featuring microfabricated structures, is a technology for manipulating fluids at the micrometer scale. The small dimension and flexibility of microfluidic systems are ideal for mimicking molecular and cellular microenvironment, and show great potential in translational research and development. Here, the recent progress of microfluidics in biological and biomedical applications, including molecular analysis, cellular analysis, and chip-based material delivery and biomimetic design is presented. The potential future developments in the translational microfluidics field are also discussed. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Advanced control technology and its potential for future transport aircraft

NASA Technical Reports Server (NTRS)

1976-01-01

The topics covered include fly by wire, digital control, control configured vehicles, applications to advanced flight vehicles, advanced propulsion control systems, and active control technology for transport aircraft.

Sustainability assessment framework for scenarios – SAFS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Arushanyan, Yevgeniya, E-mail: yevgeniya.arushanyan@abe.kth.se; KTH Royal Institute of Technology, Centre for Sustainable Communications; Ekener, Elisabeth

To address current challenges regarding sustainable development and support planning for this form of development, new learning about different possible futures and their potential sustainability implications is needed. One way of facilitating this learning is by combining the futures studies and sustainability assessment (SA) research fields. This paper presents the sustainability assessment framework for scenarios (SAFS), a method developed for assessing the environmental and social risks and opportunities of future scenarios, provides guidelines for its application and demonstrates how the framework can be applied. SAFS suggests assessing environmental and social aspects using a consumption perspective and a life cycle approach,more » and provides qualitative results. SAFS does not suggest any modelling using precise data, but instead offers guidelines on how to carry out a qualitative assessment, where both the process of assessing and the outcome of the assessment are valuable and can be used as a basis for discussion. The benefits, drawbacks and potential challenges of applying SAFS are also discussed in the paper. SAFS uses systems thinking looking at future societies as a whole, considering both environmental and social consequences. This encourages researchers and decision-makers to consider the whole picture, and not just individual elements, when considering different futures. - Highlights: • The paper presents a new methodological framework for qualitative sustainability assessment of future scenarios with transformative changes. • The framework suggests qualitative assessment with consumption perspective and a life cycle approach. • The paper presents the framework and provides guidelines for its application. • The paper demonstrates on an example how the framework can be applied. • The benefits, drawbacks and challenges of the framework application and the need for further development are discussed.« less

Nanoscience and nanotechnologies in food industries: opportunities and research trends

NASA Astrophysics Data System (ADS)

Ranjan, Shivendu; Dasgupta, Nandita; Chakraborty, Arkadyuti Roy; Melvin Samuel, S.; Ramalingam, Chidambaram; Shanker, Rishi; Kumar, Ashutosh

2014-06-01

Nanomaterials have gained importance in various fields of science, technology, medicine, colloid technologies, diagnostics, drug delivery, personal care applications and others due to their small size and unique physico-chemical characteristic. Apart from above mentioned area, it is also extensively being used in food sector specifically in preservation and packaging. The future applications in food can also be extended to improve the shelf life, food quality, safety, fortification and biosensors for contaminated or spoiled food or food packaging. Different types and shapes of nanomaterials are being employed depending upon the need and nature of the food. Characterisation of these nanomaterials is essential to understand the interaction with the food matrix and also with biological compartment. This review is focused on application of nanotechnology in food industries. It also gives insight on commercial products in market with usage of nanomaterials, current research and future aspects in these areas. Currently, they are being incorporated into commercial products at a faster rate than the development of knowledge and regulations to mitigate potential health and environmental impacts associated with their manufacturing, application and disposal. As nanomaterials are finding new application every day, care should be taken about their potential toxic effects.

Alternative Futures for Forest-Based Nanomaterials: An Application of the Manoa Schools Alternative Futures Method

Treesearch

David N. Bengston; J. Dator; Mike Dockry; A. Yee

2016-01-01

Forestry and forest products research has entered into a robust research agenda focused on creating nano-sized particles and nanoproducts from wood. As wood-based materials can be sustainably produced, the potential of these renewable products could be limitless and include high-end compostable electronics, paint-on solar panels, and lightweight materials for airplanes...

Pharmacy students' perceptions of the usefulness of motivational interviewing and the use of mobile health applications on patient counseling in the future.

PubMed

Owensby, Justin K; Kavookjian, Jan

2017-07-01

To explore student pharmacists' perceptions of 1) future patient counseling, 2) use of mobile health applications (mHealth apps), and 3) usefulness of motivational interviewing (MI) in patient encounters and potential app messaging. A cross-sectional design with first and second year pharmacy students (n=315) at a multi-campus university after exposure to mHealth app and MI curricular content. A questionnaire assessed perceptions of 1) future patient counseling, 2) using apps for personal use and professional encounters, and 3) potential practicality and usefulness of MI principles/skills in apps messaging. Over 70% of students perceived they will be counseling future patients for medication therapy/comprehensive disease management; 91% believed it is an important role as a future pharmacist. A majority own a smartphone (98%), have used an mHealth app to monitor/change a health behavior (73%), and are likely to recommend an mHealth app in future patient encounters (90%). Perceptions of counseling importance and likelihood to recommend an mHealth app varied by gender (women higher than men, p<0.01, p<0.01) and previous mHealth app use (yes higher than no, p<0.05, p<0.001). Most students reported a high likelihood of incorporating MI into current (88%) and future (91%) patient encounters and particularly noted 'supporting self-efficacy' as a useful MI principle to incorporate into mHealth app messaging. Those using apps for personal health behavior change(s) perceived future patient counseling as important and were more likely to recommend mHealth apps during those future encounters. Results may inform curricular development to prepare future pharmacists for the high-tech, patient-centered practice that is inevitable. Copyright © 2017 Elsevier Inc. All rights reserved.

Deep Learning in Nuclear Medicine and Molecular Imaging: Current Perspectives and Future Directions.

PubMed

Choi, Hongyoon

2018-04-01

Recent advances in deep learning have impacted various scientific and industrial fields. Due to the rapid application of deep learning in biomedical data, molecular imaging has also started to adopt this technique. In this regard, it is expected that deep learning will potentially affect the roles of molecular imaging experts as well as clinical decision making. This review firstly offers a basic overview of deep learning particularly for image data analysis to give knowledge to nuclear medicine physicians and researchers. Because of the unique characteristics and distinctive aims of various types of molecular imaging, deep learning applications can be different from other fields. In this context, the review deals with current perspectives of deep learning in molecular imaging particularly in terms of development of biomarkers. Finally, future challenges of deep learning application for molecular imaging and future roles of experts in molecular imaging will be discussed.

VEHICLE MASS REDUCTION STUDY | Science Inventory ...

EPA Pesticide Factsheets

Analysis of the potential to reduce light-duty vehicle mass through the application of low density or high strength materials, component consolidation, and changes to vehicle architecture. Find a holistic vehicle design approach that establishes a potential path for future feasible vehicle mass reduction in light-duty vehicles to meet more stringent GHG and Fuel Economy Standards.

Ethical Considerations and Planetary Protection for Future Space Exploration - Starting with the Basics

NASA Astrophysics Data System (ADS)

Race, Margaret

2012-07-01

As COSPAR scientists deliberate what types of frameworks and policy approaches may be applicable to future activities by various sectors in space exploration, it also needs to consider the challenging question of what ethical values and foundations should be used in dealing with life, objects and activities in outer space. A 2010 COSPAR Workshop Report on Ethical Considerations for Planetary Protection in Space Exploration recommended that it is appropriate to maintain the existing PP policy aimed at scientific concerns even as we begin to explore various practical approaches to future contamination avoidance policies. It is also appropriate to examine in parallel the ethical considerations applicable to potential indigenous extraterrestrial life, non-living extraterrestrial features and environments, and planned uses and activities involving diverse life from Earth. Since numerous sectors have begun to propose activities raising varied ethical concerns (e.g., protection and management on the moon, strip mining, space synthetic biology, space code of conduct, and commercial space transport), it is timely to initiate serious international discussions about the appropriate ethical foundations and questions applicable to future space exploration. Plans are underway for convening interdisciplinary work groups to explore and deliberate on the values (e.g., intrinsic and instrumental) and ethical foundations that are appropriate for use in deliberations involving potential indigenous extraterrestrial life and the different classes of target objects and environments in our solar system. More than ever, information on bioethics, environmental ethics and geoethics will provide helpful guidance and foundational approaches of relevance to future policy deliberations that seek to go beyond science protection per se.

Prediction markets and their potential role in biomedical research--a review.

PubMed

Pfeiffer, Thomas; Almenberg, Johan

2010-01-01

Predictions markets are marketplaces for trading contracts with payoffs that depend on the outcome of future events. Popular examples are markets on the outcome of presidential elections, where contracts pay $1 if a specific candidate wins the election and $0 if someone else wins. Contract prices on prediction markets can be interpreted as forecasts regarding the outcome of future events. Further attractive properties include the potential to aggregate private information, to generate and disseminate a consensus among the market participants, and to offer incentives for the acquisition of information. It has been argued that these properties might be valuable in the context of scientific research. In this review, we give an overview of key properties of prediction markets and discuss potential benefits for science. To illustrate these benefits for biomedical research, we discuss an example application in the context of decision making in research on the genetics of diseases. Moreover, some potential practical problems of prediction market application in science are discussed, and solutions are outlined. Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.

Nanotechnology: current uses and future applications in the food industry.

PubMed

Thiruvengadam, Muthu; Rajakumar, Govindasamy; Chung, Ill-Min

2018-01-01

Recent advances in nanoscience and nanotechnology intend new and innovative applications in the food industry. Nanotechnology exposed to be an efficient method in many fields, particularly the food industry and the area of functional foods. Though as is the circumstance with the growth of any novel food processing technology, food packaging material, or food ingredient, additional studies are needed to demonstrate the potential benefits of nanotechnologies and engineered nanomaterials designed for use in foods without adverse health effects. Nanoemulsions display numerous advantages over conventional emulsions due to the small droplets size they contain: high optical clarity, excellent physical constancy against gravitational partition and droplet accumulation, and improved bioavailability of encapsulated materials, which make them suitable for food applications. Nano-encapsulation is the most significant favorable technologies having the possibility to ensnare bioactive chemicals. This review highlights the applications of current nanotechnology research in food technology and agriculture, including nanoemulsion, nanocomposites, nanosensors, nano-encapsulation, food packaging, and propose future developments in the developing field of agrifood nanotechnology. Also, an overview of nanostructured materials, and their current applications and future perspectives in food science are also presented.

Imaging hadron calorimetry for future Lepton Colliders

NASA Astrophysics Data System (ADS)

Repond, José

2013-12-01

To fully exploit the physics potential of a future Lepton Collider requires detectors with unprecedented jet energy and dijet-mass resolution. To meet these challenges, detectors optimized for the application of Particle Flow Algorithms (PFAs) are being designed and developed. The application of PFAs, in turn, requires calorimeters with very fine segmentation of the readout, so-called imaging calorimeters. This talk reviews progress in imaging hadron calorimetry as it is being developed for implementation in a detector at a future Lepton Collider. Recent results from the large prototypes built by the CALICE Collaboration, such as the Scintillator Analog Hadron Calorimeter (AHCAL) and the Digital Hadron Calorimeters (DHCAL and SDHCAL) are being presented. In addition, various R&D efforts beyond the present prototypes are being discussed.

Current and Future Developments in Air Traffic Control

NASA Technical Reports Server (NTRS)

Jackson, Joseph; Green, Steven M.

1999-01-01

Current and future energy demands, end uses, and cost used to characterize typical applications services in the industrial sector of the United States are examined. A review and evaluation of existing industrial energy data bases was undertaken to assess their potential for supporting SERI research market suitability analysis; (2) market development; (3) end use matching; (4) industrial application studies; and (5) identification of cost and performance goals for solar systems and typical information requirements for industrial energy end use. The focus was on fuels and electric energy used for heat and power purchased by the manufacturing subsector and listed by 2, 3, and 4 digit SIC, primary fuel. The effects of federal and state industrial energy conservation programs on future industrial sector demands were assessed.

Quantifying Non-Equilibrium in Hypersonic Flows Using Entropy Generation

DTIC Science & Technology

2007-03-01

mirror fabrication, 2) mirror actuation, and 3) control algorithms with a focus on potential for future space based applications. For a...electrodes transported via a conducting electrolyte [19]. When placed under a voltage potential , cations in a polymer matrix immediately swell...has the potential to create an over- damped surface preventing Wavescope from detecting any strains. The final step in the mirror fabrication is to

A Future with Hybrid Electric Propulsion Systems: A NASA Perspective

NASA Technical Reports Server (NTRS)

DelRosario, Ruben

2014-01-01

The presentation highlights a NASA perspective on Hybrid Electric Propulsion Systems for aeronautical applications. Discussed are results from NASA Advance Concepts Study for Aircraft Entering service in 2030 and beyond and the potential use of hybrid electric propulsion systems as a potential solution to the requirements for energy efficiency and environmental compatibility. Current progress and notional potential NASA research plans are presented.

The ReaxFF reactive force-field: Development, applications, and future directions

DOE PAGES

Senftle, Thomas; Hong, Sungwook; Islam, Md Mahbubul; ...

2016-03-04

The reactive force-field (ReaxFF) interatomic potential is a powerful computational tool for exploring, developing and optimizing material properties. Methods based on the principles of quantum mechanics (QM), while offering valuable theoretical guidance at the electronic level, are often too computationally intense for simulations that consider the full dynamic evolution of a system. Alternatively, empirical interatomic potentials that are based on classical principles require significantly fewer computational resources, which enables simulations to better describe dynamic processes over longer timeframes and on larger scales. Such methods, however, typically require a predefined connectivity between atoms, precluding simulations that involve reactive events. The ReaxFFmore » method was developed to help bridge this gap. Approaching the gap from the classical side, ReaxFF casts the empirical interatomic potential within a bond-order formalism, thus implicitly describing chemical bonding without expensive QM calculations. As a result, this article provides an overview of the development, application, and future directions of the ReaxFF method.« less

Application of advanced technology to space automation

NASA Technical Reports Server (NTRS)

Schappell, R. T.; Polhemus, J. T.; Lowrie, J. W.; Hughes, C. A.; Stephens, J. R.; Chang, C. Y.

1979-01-01

Automated operations in space provide the key to optimized mission design and data acquisition at minimum cost for the future. The results of this study strongly accentuate this statement and should provide further incentive for immediate development of specific automtion technology as defined herein. Essential automation technology requirements were identified for future programs. The study was undertaken to address the future role of automation in the space program, the potential benefits to be derived, and the technology efforts that should be directed toward obtaining these benefits.

Perspective on the span-distributed-load concept for application to large cargo aircraft design

NASA Technical Reports Server (NTRS)

Whitehead, A. H., Jr.

1975-01-01

Results of a simplified analysis of the span-distributed-load concept (in which payload is placed within the wing structure) are presented. It is shown that a design based on these principles has a high potential for application to future large air cargo transport. Significant improvements are foreseen in increased payload fraction and productivity and in reduced fuel consumption and operating costs. A review of the efforts in the 1940's to develop all-wing aircraft shows the potential of transferring those early technological developments to current design of distributed-load aircraft. Current market analyses are projected to 1990 to show the future commercial demand for large capacity freighters. Several configuration designs which would serve different market requirements for these large freighters are discussed as are some of the pacing-technology requirements.

Radiant coolers - Theory, flight histories, design comparisons and future applications

NASA Technical Reports Server (NTRS)

Donohoe, M. J.; Sherman, A.; Hickman, D. E.

1975-01-01

Radiant coolers have been developed for application to the cooling of infrared detectors aboard NASA earth observation systems and as part of the Defense Meteorological Satellite Program. The prime design constraints for these coolers are the location of the cooler aboard the satellite and the satellite orbit. Flight data from several coolers indicates that, in general, design temperatures are achieved. However, potential problems relative to the contamination of cold surfaces are also revealed by the data. A comparison among the various cooler designs and flight performances indicates design improvements that can minimize the contamination problem in the future.

Potential environmental implications of nanoscale zero-valent iron particles for environmental remediation.

PubMed

Jang, Min-Hee; Lim, Myunghee; Hwang, Yu Sik

2014-01-01

Nanoscale zero-valent iron (nZVI) particles are widely used in the field of various environmental contaminant remediation. Although the potential benefits of nZVI are considerable, there is a distinct need to identify any potential risks after environmental exposure. In this respect, we review recent studies on the environmental applications and implications of nZVI, highlighting research gaps and suggesting future research directions. Environmental application of nZVI is briefly summarized, focusing on its unique properties. Ecotoxicity of nZVI is reviewed according to type of organism, including bacteria, terrestrial organisms, and aquatic organisms. The environmental fate and transport of nZVI are also summarized with regards to exposure scenarios. Finally, the current limitations of risk determination are thoroughly provided. The ecotoxicity of nZVI depends on the composition, concentration, size and surface properties of the nanoparticles and the experimental method used, including the species investigated. In addition, the environmental fate and transport of nZVI appear to be complex and depend on the exposure duration and the exposure conditions. To date, field-scale data are limited and only short-term studies using simple exposure methods have been conducted. In this regard, the primary focus of future study should be on 1) the development of an appropriate and valid testing method of the environmental fate and ecotoxicity of reactive nanoparticles used in environmental applications and 2) assessing their potential environmental risks using in situ field scale applications.

Potential environmental implications of nanoscale zero-valent iron particles for environmental remediation

PubMed Central

Jang, Min-Hee; Lim, Myunghee; Hwang, Yu Sik

2014-01-01

Objectives Nanoscale zero-valent iron (nZVI) particles are widely used in the field of various environmental contaminant remediation. Although the potential benefits of nZVI are considerable, there is a distinct need to identify any potential risks after environmental exposure. In this respect, we review recent studies on the environmental applications and implications of nZVI, highlighting research gaps and suggesting future research directions. Methods Environmental application of nZVI is briefly summarized, focusing on its unique properties. Ecotoxicity of nZVI is reviewed according to type of organism, including bacteria, terrestrial organisms, and aquatic organisms. The environmental fate and transport of nZVI are also summarized with regards to exposure scenarios. Finally, the current limitations of risk determination are thoroughly provided. Results The ecotoxicity of nZVI depends on the composition, concentration, size and surface properties of the nanoparticles and the experimental method used, including the species investigated. In addition, the environmental fate and transport of nZVI appear to be complex and depend on the exposure duration and the exposure conditions. To date, field-scale data are limited and only short-term studies using simple exposure methods have been conducted. Conclusions In this regard, the primary focus of future study should be on 1) the development of an appropriate and valid testing method of the environmental fate and ecotoxicity of reactive nanoparticles used in environmental applications and 2) assessing their potential environmental risks using in situ field scale applications. PMID:25518840

A potassium Rankine multimegawatt nuclear electric propulsion concept

NASA Technical Reports Server (NTRS)

Baumeister, E.; Rovang, R.; Mills, J.; Sercel, J.; Frisbee, R.

1990-01-01

Multimegawatt nuclear electric propulsion (NEP) has been identified as a potentially attractive option for future space exploratory missions. A liquid-metal-cooled reactor, potassium Rankine power system that is being developed is suited to fulfill this application. The key features of the nuclear power system are described, and system characteristics are provided for various potential NEP power ranges and operational lifetimes. The results of recent mission studies are presented to illustrate some of the potential benefits to future space exploration to be gained from high-power NEP. Specifically, mission analyses have been performed to assess the mass and trip time performance of advanced NEP for both cargo and piloted missions to Mars.

Magnetized jet creation using a ring laser and applications

NASA Astrophysics Data System (ADS)

Liang, Edison; Gao, Ian; Lu, Yingchao; Ji, Hantao; Follett, Russ; Froula, Dustin; Tzeferacos, Petros; Lamb, Donald; Bickel, Andrew; Sio, Hong; Li, Chi Kiang; Petrasso, Richard; Wei, Mingsheng; Fu, Wen; Han, Lily

2017-10-01

We have recently demonstrated a new robust platform of magnetized jet creation using 20 OMEGA beams to form a hollow ring. We will present the latest experimental results and their theoretical interpretation, and explore potential applications to laboratory astrophysics, fundamental plasma physics and other areas. We will also discuss the scaling of this platform to future NIF experiments.

Perspective on intelligent avionics

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jones, H.L.

1987-01-01

Technical issues which could potentially limit the capability and acceptibility of expert systems decision-making for avionics applications are addressed. These issues are: real-time AI, mission-critical software, conventional algorithms, pilot interface, knowledge acquisition, and distributed expert systems. Examples from on-going expert system development programs are presented to illustrate likely architectures and applications of future intelligent avionic systems. 13 references.

Applications of aerospace technology in the environmental sciences

NASA Technical Reports Server (NTRS)

1972-01-01

Detailed information is reported on the operations and accomplishments of the RTI Technology Application Team for the period October 11, 1971 to March 10, 1972. Mathematical models for prediction of pollutant formation during combustion are discussed along with generic areas of air pollution problems, which NASA technology offers a high potential for solving. Recommendations for future work are included.

From POEM to POET: Applications and perspectives for submucosal tunnel endoscopy.

PubMed

Chiu, Philip W Y; Inoue, Haruhiro; Rösch, Thomas

2016-12-01

Recent advances in submucosal endoscopy have unlocked a new horizon for potential development in diagnostic and therapeutic endoscopy. Increasing evidence has demonstrated that peroral endoscopic myotomy (POEM) is not only clinically feasible and safe, but also has excellent results in symptomatic relief of achalasia. The success of submucosal endoscopy in performance of tumor resection has confirmed the potential of this new area in diagnostic and therapeutic endoscopy. This article reviews the current applications and evidence, from POEM to peroral endoscopic tunnel resection (POET), while exploring the possible future clinical applications in this field. © Georg Thieme Verlag KG Stuttgart · New York.

Properties and applications of chemically functionalized graphene.

PubMed

Craciun, M F; Khrapach, I; Barnes, M D; Russo, S

2013-10-23

The vast and yet largely unexplored family of graphene materials has great potential for future electronic devices with novel functionalities. The ability to engineer the electrical and optical properties in graphene by chemically functionalizing it with a molecule or adatom is widening considerably the potential applications targeted by graphene. Indeed, functionalized graphene has been found to be the best known transparent conductor or a wide gap semiconductor. At the same time, understanding the mechanisms driving the functionalization of graphene with hydrogen is proving to be of fundamental interest for energy storage devices. Here we discuss recent advances on the properties and applications of chemically functionalized graphene.

Graphene Materials in Antimicrobial Nanomedicine: Current Status and Future Perspectives.

PubMed

Karahan, Hüseyin Enis; Wiraja, Christian; Xu, Chenjie; Wei, Jun; Wang, Yilei; Wang, Liang; Liu, Fei; Chen, Yuan

2018-03-05

Graphene materials (GMs), such as graphene, graphene oxide (GO), reduced GO (rGO), and graphene quantum dots (GQDs), are rapidly emerging as a new class of broad-spectrum antimicrobial agents. This report describes their state-of-the-art and potential future covering both fundamental aspects and biomedical applications. First, the current understanding of the antimicrobial mechanisms of GMs is illustrated, and the complex picture of underlying structure-property-activity relationships is sketched. Next, the different modes of utilization of antimicrobial GMs are explained, which include their use as colloidal dispersions, surface coatings, and photothermal/photodynamic therapy agents. Due to their practical relevance, the examples where GMs function as synergistic agents or release platforms for metal ions and/or antibiotic drugs are also discussed. Later, the applicability of GMs in the design of wound dressings, infection-protective coatings, and antibiotic-like formulations ("nanoantibiotics") is assessed. Notably, to support our assessments, the existing clinical applications of conventional carbon materials are also evaluated. Finally, the key hurdles of the field are highlighted, and several possible directions for future investigations are proposed. We hope that the roadmap provided here will encourage researchers to tackle remaining challenges toward clinical translation of promising research findings and help realize the potential of GMs in antimicrobial nanomedicine. © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Transit Vehicle-to-Infrastructure (V2I) assessment study.

DOT National Transportation Integrated Search

2015-07-01

The United States Department of Transportation (USDOT) is engaged in assessing applications that realize the full potential of connected vehicles, travelers, and infrastructure to enhance current operational practices and transform future surface tra...

Design, cost, and advanced technology applications for a military trainer aircraft

NASA Technical Reports Server (NTRS)

Hill, G. C.; Harper, M.

1975-01-01

The potential impact is examined of advanced aerodynamic and propulsive technologies in terms of operating and acquisition costs on conceptual mission and performance requirements for a future undergraduate jet pilot trainer aircraft.

NASA's Earth Resources Laboratory - Seventeen years of using remotely sensed satellite data in land applications

NASA Technical Reports Server (NTRS)

Cashion, Kenneth D.; Whitehurst, Charles A.

1987-01-01

The activities of the Earth Resources Laboratoy (ERL) for the past seventeen years are reviewed with particular reference to four typical applications demonstrating the use of remotely sensed data in a geobased information system context. The applications discussed are: a fire control model for the Olympic National Park; wildlife habitat modeling; a resource inventory system including a potential soil erosion model; and a corridor analysis model for locating routes between geographical locations. Some future applications are also discussed.

Piezoelectric actuators for active optics

NASA Astrophysics Data System (ADS)

Le Letty, R.; Barillot, F.; Fabbro, H.; Guay, Ph.; Cadiergues, L.

2017-11-01

Piezoelectric actuators find their first applications in active space optics. The purpose of this paper is to describe the state of the art and some applications. Piezo actuators display attractive features for space applications, such as precise positioning, unlubricated, non magnetic and compact features, and low power consumption. However, piezo mechanisms cannot be considered separately from their driving and control electronic. Piezo actuators, such as Amplified Piezo Actuators or Parallel Pre-stressed Actuators, initially designed under CNES contracts, shall find their first space flight applications in optics on the PHARAO Laser bench: • fine pointing of the laser beams, • laser cavity tuning. Breadboard mechanisms based on piezo actuators have also been tested for refocusing purposes. Other applications includes the improvement of the CCD resolution through an oversampling technique, such as in the SOHO/LASCO instrument, fast optical shutter operation, optical filter in combination with a Fabry - Perot interferometer, such as in future LIDAR for earth observation. The first applications shall be described and an overview of the future potential applications shall be given.

Bio-Inspired Extreme Wetting Surfaces for Biomedical Applications

PubMed Central

Shin, Sera; Seo, Jungmok; Han, Heetak; Kang, Subin; Kim, Hyunchul; Lee, Taeyoon

2016-01-01

Biological creatures with unique surface wettability have long served as a source of inspiration for scientists and engineers. More specifically, materials exhibiting extreme wetting properties, such as superhydrophilic and superhydrophobic surfaces, have attracted considerable attention because of their potential use in various applications, such as self-cleaning fabrics, anti-fog windows, anti-corrosive coatings, drag-reduction systems, and efficient water transportation. In particular, the engineering of surface wettability by manipulating chemical properties and structure opens emerging biomedical applications ranging from high-throughput cell culture platforms to biomedical devices. This review describes design and fabrication methods for artificial extreme wetting surfaces. Next, we introduce some of the newer and emerging biomedical applications using extreme wetting surfaces. Current challenges and future prospects of the surfaces for potential biomedical applications are also addressed. PMID:28787916

Application of remote sensing to state and regional problems

NASA Technical Reports Server (NTRS)

Miller, W. F.; Clark, J. R.; Solomon, J. L.; Duffy, B.; Minchew, K.; Wright, L. H. (Principal Investigator)

1981-01-01

The objectives, accomplishments, and future plans of several LANDSAT applications projects in Mississippi are discussed. The applications include land use planning in Lowandes County, strip mine inventory and reclamation, white tailed deer habitat evaluation, data analysis support systems, discrimination of forest habitats in potential lignite areas, changes in gravel operations, and determination of freshwater wetlands for inventory and monitoring. In addition, a conceptual design for a LANDSAT based information system is discussed.

Bandgap Optimization of Perovskite Semiconductors for Photovoltaic Applications.

PubMed

Xiao, Zewen; Zhou, Yuanyuan; Hosono, Hideo; Kamiya, Toshio; Padture, Nitin P

2018-02-16

The bandgap is the most important physical property that determines the potential of semiconductors for photovoltaic (PV) applications. This Minireview discusses the parameters affecting the bandgap of perovskite semiconductors that are being widely studied for PV applications, and the recent progress in the optimization of the bandgaps of these materials. Perspectives are also provided for guiding future research in this area. © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Spectrally Tailored Pulsed Thulium Fiber Laser System for Broadband Lidar CO2 Sensing

NASA Technical Reports Server (NTRS)

Heaps, William S.; Georgieva, Elena M.; McComb, Timothy S.; Cheung, Eric C.; Hassell, Frank R.; Baldauf, Brian K.

2011-01-01

Thulium doped pulsed fiber lasers are capable of meeting the spectral, temporal, efficiency, size and weight demands of defense and civil applications for pulsed lasers in the eye-safe spectral regime due to inherent mechanical stability, compact "all-fiber" master oscillator power amplifier (MOPA) architectures, high beam quality and efficiency. Thulium fiber's longer operating wavelength allows use of larger fiber cores without compromising beam quality, increasing potential single aperture pulse energies. Applications of these lasers include eye-safe laser ranging, frequency conversion to longer or shorter wavelengths for IR countermeasures and sensing applications with otherwise tough to achieve wavelengths and detection of atmospheric species including CO2 and water vapor. Performance of a portable thulium fiber laser system developed for CO2 sensing via a broadband lidar technique with an etalon based sensor will be discussed. The fielded laser operates with approximately 280 J pulse energy in 90-150ns pulses over a tunable 110nm spectral range and has a uniquely tailored broadband spectral output allowing the sensing of multiple CO2 lines simultaneously, simplifying future potentially space based CO2 sensing instruments by reducing the number and complexity of lasers required to carry out high precision sensing missions. Power scaling and future "all fiber" system configurations for a number of ranging, sensing, countermeasures and other yet to be defined applications by use of flexible spectral and temporal performance master oscillators will be discussed. The compact, low mass, robust, efficient and readily power scalable nature of "all-fiber" thulium lasers makes them ideal candidates for use in future space based sensing applications.

Applications of space observations to the management and utilization of coastal fishery resources

NASA Technical Reports Server (NTRS)

Kemmerer, A. J.; Savastano, K. J.; Faller, K. H.

1977-01-01

Information needs of those concerned with the harvest and management of coastal fishery resources can be satisfied in part through applications of satellite remote sensing. Recently completed and ongoing investigations have demonstrated potentials for defining fish distribution patterns from multispectral data, monitoring fishing distribution and effort with synthetic aperture radar systems, forecasting recruitment of certain estuarine-dependent species, and tracking marine mammals. These investigations, which are reviewed in this paper, have relied on Landsat 1 and 2, Skylab-3, and Nimbus-6 supported sensors and sensors carried by aircraft and mounted on surface platforms to simulate applications from Seasat-A and other future spacecraft systems. None of the systems are operational as all were designed to identify and demonstrate applications and to aid in the specification of requirements for future spaceborne systems.

ECOTOX database; new additions and future direction

EPA Science Inventory

The ECOTOXicology database (ECOTOX) is a comprehensive, publicly available knowledgebase developed and maintained by ORD/NHEERL. It is used for environmental toxicity data on aquatic life, terrestrial plants and wildlife. Publications are identified for potential applicability af...

Conducting Polymers and Their Applications in Diabetes Management.

PubMed

Zhao, Yu; Cao, Luyao; Li, Lanlan; Cheng, Wen; Xu, Liangliang; Ping, Xinyu; Pan, Lijia; Shi, Yi

2016-10-26

Advances in conducting polymers (CPs) have promoted the development of diabetic monitoring and treatment, which is of great significance in human healthcare and modern medicine. CPs are special polymers with physical and electrochemical features resembling metals, inorganic semiconductors and non-conducting polymers. To improve and extend their properties, the fabrication of CPs and CP composites has attracted intensive attention in recent decades. Some CPs are biocompatible and suitable for biomedical use. Thus, the intriguing properties of CPs make wearable, noninvasive, continuous diabetes managing devices and other potential applications in diabetes possible in the near future. To highlight the recent advances of CPs and their derived materials (especially in conducting polymer hydrogels), here we discuss their fabrication and characterization, review the current state-of-the-art research in diabetes management based on these materials and describe current challenges as well as future potential research directions.

Conducting Polymers and Their Applications in Diabetes Management

PubMed Central

Zhao, Yu; Cao, Luyao; Li, Lanlan; Cheng, Wen; Xu, Liangliang; Ping, Xinyu; Pan, Lijia; Shi, Yi

2016-01-01

Advances in conducting polymers (CPs) have promoted the development of diabetic monitoring and treatment, which is of great significance in human healthcare and modern medicine. CPs are special polymers with physical and electrochemical features resembling metals, inorganic semiconductors and non-conducting polymers. To improve and extend their properties, the fabrication of CPs and CP composites has attracted intensive attention in recent decades. Some CPs are biocompatible and suitable for biomedical use. Thus, the intriguing properties of CPs make wearable, noninvasive, continuous diabetes managing devices and other potential applications in diabetes possible in the near future. To highlight the recent advances of CPs and their derived materials (especially in conducting polymer hydrogels), here we discuss their fabrication and characterization, review the current state-of-the-art research in diabetes management based on these materials and describe current challenges as well as future potential research directions. PMID:27792179

Designing augmentative and alternative communication applications: the results of focus groups with speech-language pathologists and parents of children with autism spectrum disorder.

PubMed

Boster, Jamie B; McCarthy, John W

2018-05-01

The purpose of this study was to gain insight from speech-language pathologists (SLPs) and parents of children with autism spectrum disorder (ASD) regarding appealing features of augmentative and alternative communication (AAC) applications. Two separate 1-hour focus groups were conducted with 8 SLPs and 5 parents of children with ASD to identify appealing design features of AAC Apps, their benefits and potential concerns. Participants were shown novel interface designs for communication mode, play mode and incentive systems. Participants responded to poll questions and provided benefits and drawbacks of the features as part of structured discussion. SLPs and parents identified a range of appealing features in communication mode (customization, animation and colour-coding) as well as in play mode (games and videos). SLPs preferred interfaces that supported motor planning and instruction while parents preferred those features such as character assistants that would appeal to their child. Overall SLPs and parents agreed on features for future AAC Apps. SLPs and parents have valuable input in regards to future AAC app design informed by their experiences with children with ASD. Both groups are key stakeholders in the design process and should be included in future design and research endeavors. Implications for Rehabilitation AAC applications for the iPad are often designed based on previous devices without consideration of new features. Ensuring the design of new interfaces are appealing and beneficial for children with ASD can potentially further support their communication. This study demonstrates how key stakeholders in AAC including speech language pathologists and parents can provide information to support the development of future AAC interface designs. Key stakeholders may be an untapped resource in the development of future AAC interfaces for children with ASD.

The concepts and applications of tissue engineering in otorhinolaryngology.

PubMed

Ribeiro, Leandro; Castro, Eugénia; Ferreira, Manuela; Helena, Diamantino; Robles, Raquel; Faria E Almeida, António; Condé, Artur

2015-01-01

Tissue engineering is a rapidly developing field that, making biological substitutes for the repair and regeneration of damaged tissues, will play an important role in the future of otorhinolaryngology. In this article we explain the principles of regenerative medicine and its potential applications in Otorhinolaryngology. The authors searched the published literature on this topic, chose relevant references, and extracted and systematized the data. There are some exciting possibilities for future treatments in otorhinolaryngology applying the concepts of tissue engineering. Copyright © 2014 Elsevier España, S.L.U. and Sociedad Española de Otorrinolaringología y Patología Cérvico-Facial. All rights reserved.

Thymoquinone, as an anticancer molecule: from basic research to clinical investigation

PubMed Central

Asaduzzaman Khan, Md.; Tania, Mousumi; Fu, Shangyi; Fu, Junjiang

2017-01-01

Thymoquinone is an anticancer phytochemical commonly found in black cumin. In this review, we discuss the potential of thymoquinone as anticancer molecule, its mechanism of action and future usage in clinical applications. Thymoquinone exhibits anticancer activity via numerous mechanisms of action, specifically by showing selective antioxidant and oxidant activity, interfering with DNA structure, affecting carcinogenic signaling molecules/pathways and immunomodulation. In vitro activity of thymoquinone has been further implicated in animal models of cancer; however, no clinical application has been proven yet. This is the optimum time to focus on clinical trials for developing thymoquinone as a future drug in cancer therapeutics. PMID:28881699

Thymoquinone, as an anticancer molecule: from basic research to clinical investigation.

PubMed

Asaduzzaman Khan, Md; Tania, Mousumi; Fu, Shangyi; Fu, Junjiang

2017-08-01

Thymoquinone is an anticancer phytochemical commonly found in black cumin. In this review, we discuss the potential of thymoquinone as anticancer molecule, its mechanism of action and future usage in clinical applications. Thymoquinone exhibits anticancer activity via numerous mechanisms of action, specifically by showing selective antioxidant and oxidant activity, interfering with DNA structure, affecting carcinogenic signaling molecules/pathways and immunomodulation. In vitro activity of thymoquinone has been further implicated in animal models of cancer; however, no clinical application has been proven yet. This is the optimum time to focus on clinical trials for developing thymoquinone as a future drug in cancer therapeutics.

Genome elimination: translating basic research into a future tool for plant breeding.

PubMed

Comai, Luca

2014-06-01

During the course of our history, humankind has been through different periods of agricultural improvement aimed at enhancing our food supply and the performance of food crops. In recent years, it has become apparent that future crop improvement efforts will require new approaches to address the local challenges of farmers while empowering discovery across industry and academia. New plant breeding approaches are needed to meet this challenge to help feed a growing world population. Here I discuss how a basic research discovery is being translated into a potential future tool for plant breeding, and share the story of researcher Simon Chan, who recognized the potential application of this new approach--genome elimination--for the breeding of staple food crops in Africa and South America.

NASA advanced space photovoltaic technology-status, potential and future mission applications

NASA Technical Reports Server (NTRS)

Flood, Dennis J.; Piszczor, Michael, Jr.; Stella, Paul M.; Bennett, Gary L.

1989-01-01

The NASA program in space photovoltaic research and development encompasses a wide range of emerging options for future space power systems, and includes both cell and array technology development. The long range goals are to develop technology capable of achieving 300 W/kg for planar arrays, and 300 W/sq m for concentrator arrays. InP and GaAs planar and concentrator cell technologies are under investigation for their potential high efficiency and good radiation resistance. The Advanced Photovoltaic Solar Array (APSA) program is a near term effort aimed at demonstrating 130 W/kg beginning of life specific power using thin (62 micrometer) silicon cells. It is intended to be technology transparent to future high efficiency cells and provides the baseline for development of the 300 W/kg array.

Utilization management in radiology, part 2: perspectives and future directions.

PubMed

Duszak, Richard; Berlin, Jonathan W

2012-10-01

Increased utilization of medical imaging in the early part of the last decade has resulted in numerous efforts to reduce associated spending. Recent initiatives have focused on managing utilization with radiology benefits managers and real-time order entry decision support systems. Although these approaches might seem mutually exclusive and their application to radiology appears unique, the historical convergence and broad acceptance of both programs within the pharmacy sector may offer parallels for their potential future in medical imaging. In this second installment of a two-part series, anticipated trends in radiology utilization management are reviewed. Perspectives on current and future potential roles of radiologists in such initiatives are discussed, particularly in light of emerging physician payment models. Copyright © 2012 American College of Radiology. Published by Elsevier Inc. All rights reserved.

Looking for practical tools to achieve next-future applicability of dark fermentation to produce bio-hydrogen from organic materials in Continuously Stirred Tank Reactors.

PubMed

Tenca, A; Schievano, A; Lonati, S; Malagutti, L; Oberti, R; Adani, F

2011-09-01

This study aimed at finding applicable tools for favouring dark fermentation application in full-scale biogas plants in the next future. Firstly, the focus was obtaining mixed microbial cultures from natural sources (soil-inocula and anaerobically digested materials), able to efficiently produce bio-hydrogen by dark fermentation. Batch reactors with proper substrate (1 gL(glucose)(-1)) and metabolites concentrations, allowed high H(2) yields (2.8 ± 0.66 mol H(2)mol(glucose)(-1)), comparable to pure microbial cultures achievements. The application of this methodology to four organic substrates, of possible interest for full-scale plants, showed promising and repeatable bio-H(2) potential (BHP=202 ± 3 NL(H2)kg(VS)(-1)) from organic fraction of municipal source-separated waste (OFMSW). Nevertheless, the fermentation in a lab-scale CSTR (nowadays the most diffused typology of biogas-plant) of a concentrated organic mixture of OFMSW (126 g(TS)L(-1)) resulted in only 30% of its BHP, showing that further improvements are still needed for future full-scale applications of dark fermentation. Copyright © 2011 Elsevier Ltd. All rights reserved.

Head in the Clouds: A Review of Current and Future Potential for Cloud-Enabled Pedagogies

ERIC Educational Resources Information Center

Stevenson, Michael; Hedberg, John G.

2011-01-01

This paper reviews the research on the disruptive and transformative potential of newly-emerging cloud-based pedagogies. It takes into consideration the extent to which Cloud Computing can be leveraged to disseminate and scale web-based applications within and across learning contexts. It examines ideas from current literature in Web 2.0- and…

From nZVI to SNCs: development of a better material for pollutant removal in water.

PubMed

Fang, Ying; Wen, Jia; Zeng, Guangming; Shen, Maocai; Cao, Weicheng; Gong, Jilai; Zhang, Yaxin

2018-03-01

Nanoscale zero-valent iron (nZVI), with its reductive potentials and wide availability, offers degradative remediation for environmental pollutants. However, weaknesses such as easy aggregation, easy oxidation, and nanoscale size have hindered its further applications in the environment to some extent. Therefore, various supported nZVI composites (SNCs) with higher dispersibility, enhanced water stability, and tunable size have been developed to overcome the weaknesses. SNCs family is a great alternative for water purification applications that require high removal efficiency and rapid kinetics, as a result of their multifunctional properties and magnetic separation capacity. In this review, we compare the advantages of SNCs to nZVI for pollutant removal in water, discuss for the first time the synthetic techniques of obtaining SNCs, and analyze the influencing factors and mechanisms associated with the removal of some typical hazardous pollutants (e.g., dyes, heavy metals, nitrogen, and phosphorus) using SNCs. Moreover, limitations and future research needs of such material are discussed. More attention should be paid to the evaluation of toxicity, development of green synthetic routes, and potential application areas of such materials in future research.

Intelligent tutoring systems for space applications

NASA Technical Reports Server (NTRS)

Luckhardt-Redfield, Carol A.

1990-01-01

Artificial Intelligence has been used in many space applications. Intelligent tutoring systems (ITSs) have only recently been developed for assisting training of space operations and skills. An ITS at Southwest Research Institute is described as an example of an ITS application for space operations, specifically, training console operations at mission control. A distinction is made between critical skills and knowledge versus routine skills. Other ITSs for space are also discussed and future training requirements and potential ITS solutions are described.

Gas-phase broadband spectroscopy using active sources: progress, status, and applications

PubMed Central

Cossel, Kevin C.; Waxman, Eleanor M.; Finneran, Ian A.; Blake, Geoffrey A.; Ye, Jun; Newbury, Nathan R.

2017-01-01

Broadband spectroscopy is an invaluable tool for measuring multiple gas-phase species simultaneously. In this work we review basic techniques, implementations, and current applications for broadband spectroscopy. We discuss components of broad-band spectroscopy including light sources, absorption cells, and detection methods and then discuss specific combinations of these components in commonly-used techniques. We finish this review by discussing potential future advances in techniques and applications of broad-band spectroscopy. PMID:28630530

Are mobile health applications useful for supporting shared decision making in diagnostic and treatment decisions?

PubMed Central

Abbasgholizadeh Rahimi, Samira; Menear, Matthew; Robitaille, Hubert; Légaré, France

2017-01-01

ABSTRACT Mobile health (mHealth) applications intended to support shared decision making in diagnostic and treatment decisions are increasingly available. In this paper, we discuss some recent studies on mHealth applications with relevance to shared decision making. We discuss the potential advantages and disadvantages of using mHealth in shared decision making in various contexts, and suggest some directions for future research in this quickly expanding field. PMID:28838306

Nanotoxicology: the present and the future

EPA Science Inventory

Engineered nanomaterials, due to their unique properties, can enable novel applications, but at the same time raise concern about potential toxicity. The knowledge of nanotoxicology developed quickly in recent years on not only the biological effects of nanomaterials, but also on...

Virtual Reality: An Overview.

ERIC Educational Resources Information Center

Franchi, Jorge

1994-01-01

Highlights of this overview of virtual reality include optics; interface devices; virtual worlds; potential applications, including medicine and archaeology; problems, including costs; current research and development; future possibilities; and a listing of vendors and suppliers of virtual reality products. (Contains 11 references.) (LRW)

Lessons learned on the Skylab program

NASA Technical Reports Server (NTRS)

1974-01-01

Lessons learned in the Skylab program and their application and adaptation to other space programs are summarized. Recommendations and action taken on particular problems are described. The use of Skylab recommendations to identify potential problems of future space programs is discussed.

Integrating model abstraction into monitoring strategies

USDA-ARS?s Scientific Manuscript database

This study was designed and performed to investigate the opportunities and benefits of integrating model abstraction techniques into monitoring strategies. The study focused on future applications of modeling to contingency planning and management of potential and actual contaminant release sites wi...

77 FR 28316 - Filing a Renewed License Application

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-14

... only those environmental impacts and alternatives that are reasonably foreseeable. This means that... action timeframe. With respect to assessing the potential future environmental impacts associated with... its consideration of impacts in the generic and supplemental environmental impact statements (SEISs...

Computer Based Expert Systems.

ERIC Educational Resources Information Center

Parry, James D.; Ferrara, Joseph M.

1985-01-01

Claims knowledge-based expert computer systems can meet needs of rural schools for affordable expert advice and support and will play an important role in the future of rural education. Describes potential applications in prediction, interpretation, diagnosis, remediation, planning, monitoring, and instruction. (NEC)

Quantifying the effect of autonomous adaptation to global river flood projections: application to future flood risk assessments

NASA Astrophysics Data System (ADS)

Kinoshita, Youhei; Tanoue, Masahiro; Watanabe, Satoshi; Hirabayashi, Yukiko

2018-01-01

This study represents the first attempt to quantify the effects of autonomous adaptation on the projection of global flood hazards and to assess future flood risk by including this effect. A vulnerability scenario, which varies according to the autonomous adaptation effect for conventional disaster mitigation efforts, was developed based on historical vulnerability values derived from flood damage records and a river inundation simulation. Coupled with general circulation model outputs and future socioeconomic scenarios, potential future flood fatalities and economic loss were estimated. By including the effect of autonomous adaptation, our multimodel ensemble estimates projected a 2.0% decrease in potential flood fatalities and an 821% increase in potential economic losses by 2100 under the highest emission scenario together with a large population increase. Vulnerability changes reduced potential flood consequences by 64%-72% in terms of potential fatalities and 28%-42% in terms of potential economic losses by 2100. Although socioeconomic changes made the greatest contribution to the potential increased consequences of future floods, about a half of the increase of potential economic losses was mitigated by autonomous adaptation. There is a clear and positive relationship between the global temperature increase from the pre-industrial level and the estimated mean potential flood economic loss, while there is a negative relationship with potential fatalities due to the autonomous adaptation effect. A bootstrapping analysis suggests a significant increase in potential flood fatalities (+5.7%) without any adaptation if the temperature increases by 1.5 °C-2.0 °C, whereas the increase in potential economic loss (+0.9%) was not significant. Our method enables the effects of autonomous adaptation and additional adaptation efforts on climate-induced hazards to be distinguished, which would be essential for the accurate estimation of the cost of adaptation to climate change.

On the application potential of gold nanoparticles in nanoelectronics and biomedicine.

PubMed

Homberger, Melanie; Simon, Ulrich

2010-03-28

Ligand-stabilized gold nanoparticles (AuNPs) are of high interest to research dedicated to future technologies such as nanoelectronics or biomedical applications. This research interest arises from the unique size-dependent properties such as surface plasmon resonance or Coulomb charging effects. It is shown here how the unique properties of individual AuNPs and AuNP assemblies can be used to create new functional materials for applications in a technical or biological environment. While the term technical environment focuses on the potential use of AuNPs as subunits in nanoelectronic devices, the term biological environment addresses issues of toxicity and novel concepts of controlling biomolecular reactions on the surface of AuNPs.

Survey of advanced nuclear technologies for potential applications of sonoprocessing.

PubMed

Rubio, Floren; Blandford, Edward D; Bond, Leonard J

2016-09-01

Ultrasonics has been used in many industrial applications for both sensing at low power and processing at higher power. Generally, the high power applications fall within the categories of liquid stream degassing, impurity separation, and sonochemical enhancement of chemical processes. Examples of such industrial applications include metal production, food processing, chemical production, and pharmaceutical production. There are many nuclear process streams that have similar physical and chemical processes to those applications listed above. These nuclear processes could potentially benefit from the use of high-power ultrasonics. There are also potential benefits to applying these techniques in advanced nuclear fuel cycle processes, and these benefits have not been fully investigated. Currently the dominant use of ultrasonic technology in the nuclear industry has been using low power ultrasonics for non-destructive testing/evaluation (NDT/NDE), where it is primarily used for inspections and for characterizing material degradation. Because there has been very little consideration given to how sonoprocessing can potentially improve efficiency and add value to important process streams throughout the nuclear fuel cycle, there are numerous opportunities for improvement in current and future nuclear technologies. In this paper, the relevant fundamental theory underlying sonoprocessing is highlighted, and some potential applications to advanced nuclear technologies throughout the nuclear fuel cycle are discussed. Copyright © 2016 Elsevier B.V. All rights reserved.

Telehealth innovations in health education and training.

PubMed

Conde, José G; De, Suvranu; Hall, Richard W; Johansen, Edward; Meglan, Dwight; Peng, Grace C Y

2010-01-01

Telehealth applications are increasingly important in many areas of health education and training. In addition, they will play a vital role in biomedical research and research training by facilitating remote collaborations and providing access to expensive/remote instrumentation. In order to fulfill their true potential to leverage education, training, and research activities, innovations in telehealth applications should be fostered across a range of technology fronts, including online, on-demand computational models for simulation; simplified interfaces for software and hardware; software frameworks for simulations; portable telepresence systems; artificial intelligence applications to be applied when simulated human patients are not options; and the development of more simulator applications. This article presents the results of discussion on potential areas of future development, barries to overcome, and suggestions to translate the promise of telehealth applications into a transformed environment of training, education, and research in the health sciences.

Open System Interconnection - NASA program communications of the future. [developed by International aorganization for Standardization

NASA Technical Reports Server (NTRS)

Brady, Charles D.

1987-01-01

Open Systems Interconnection (OSI) standards are being developed by the ISO and the Consultative Committee on International Telephone and Telegraph with the support of industry. These standards are being developed to allow the interconnecting of computer systems and the interworking of applications such that the applications can be independent of any equipment manufacturer. Significant progress has been made, and the establishment of government OSI standards is being considered. There is considerable interest within NASA in the potential benefits of OSI and in communications standards in general. The OSI standards are being considered for possible application in the Space Station onboard data management system. The OSI standards have reached a high level of maturity, and it is now imperative that NASA plan for future migration to OSI where appropriate.

Managing immune diseases in the smartphone era: how have apps impacted disease management and their future?

PubMed

Gallagher, Joe; O'Donoghue, John; Car, Josip

2015-04-01

Immunology, similar to other areas of clinical science, is a data-rich discipline that involves a great deal of interaction between healthcare professionals and their patients. The focus of this editorial is to review the challenges and opportunities for mobile healthcare applications within immunology. It is clear that further research is required to fully maximize the potential of mobile apps (e.g., regulations and guidelines, electronic health). However, it is equally clear that mobile healthcare applications have had a positive impact on patient outcomes (better response rates, more efficient usage of time and more accurate diagnosis). Overall, healthcare applications have a fundamental role to play in the future management of diseases as they will help to ensure that we deliver more effective patient care.

Nanotechnology-based restorative materials for dental caries management

PubMed Central

Melo, Mary A.S.; Guedes, Sarah F.F.; Xu, Hockin H.K.; Rodrigues, Lidiany K.A.

2013-01-01

Nanotechnology has been applied to dental materials as an innovative concept for the development of materials with better properties and anticaries potential. In this review we discuss the current progress and future applications of functional nanoparticles incorporated in dental restorative materials as useful strategies to dental caries management. We also overview proposed antimicrobial and remineralizing mechanisms. Nanomaterials have great potential to decrease biofilm accumulation, inhibit the demineralization process, to be used for remineralizing tooth structure, and to combat caries-related bacteria. These results are encouraging and open the doors to future clinical studies that will allow the therapeutic value of nanotechnology-based restorative materials to be established. PMID:23810638

High Pulse Repetition Rate, Eye Safe, Visible Wavelength Lidar Systems: Design, Results and Potential

NASA Technical Reports Server (NTRS)

Spinhirne, James; Berkoff, Timothy; Welton, Elsworth; Campbell, James; OCStarr, David (Technical Monitor)

2002-01-01

In 1993 the first of the eye safe visible wavelength lidar systems known now as Micro Pulse Lidar (MPL) became operational. Since that time there have been several dozen of these systems produced and applied for full time profiling of atmospheric cloud and aerosol structure. There is currently an observational network of MPL sites to support global climate research. In the course of application of these instruments there have been significant improvements in understanding, design and performance of the systems. There are addition potential and applications beyond current practice for the high repetition rate, eye safe designs. The MPL network and the current capability, design and future potential of MPL systems are described.

Near-infrared fluorescence image-guidance in plastic surgery: A systematic review.

PubMed

Cornelissen, Anouk J M; van Mulken, Tom J M; Graupner, Caitlin; Qiu, Shan S; Keuter, Xavier H A; van der Hulst, René R W J; Schols, Rutger M

2018-01-01

Near-infrared fluorescence (NIRF) imaging technique, after administration of contrast agents with fluorescent characteristics in the near-infrared (700-900 nm) range, is considered to possess great potential for the future of plastic surgery, given its capacity for perioperative, real-time anatomical guidance and identification. This study aimed to provide a comprehensive literature review concerning current and potential future applications of NIRF imaging in plastic surgery, thereby guiding future research. A systematic literature search was performed in databases of Cochrane Library CENTRAL, MEDLINE, and EMBASE (last search Oct 2017) regarding NIRF imaging in plastic surgery. Identified articles were screened and checked for eligibility by two authors independently. Forty-eight selected studies included 1166 animal/human subjects in total. NIRF imaging was described for a variety of (pre)clinical applications in plastic surgery. Thirty-two articles used NIRF angiography, i.e., vascular imaging after intravenous dye administration. Ten articles reported on NIRF lymphography after subcutaneous dye administration. Although currently most applied, general protocols for dosage and timing of dye administration for NIRF angiography and lymphography are still lacking. Three articles applied NIRF to detect nerve injury, and another three studies described other novel applications in plastic surgery. Future standard implementation of novel intraoperative optical techniques, such as NIRF imaging, could significantly contribute to perioperative anatomy guidance and facilitate critical decision-making in plastic surgical procedures. Further investigation (i.e., large multicenter randomized controlled trials) is mandatory to establish the true value of this innovative surgical imaging technique in standard clinical practice and to aid in forming consensus on protocols for general use.Level of Evidence: Not ratable.

Special Issue: NextGen Materials for 3D Printing.

PubMed

Chua, Chee Kai; Yeong, Wai Yee; An, Jia

2018-04-04

Only a handful of materials are well-established in three-dimensional (3D) printing and well-accepted in industrial manufacturing applications. However, recent advances in 3D printable materials have shown potential for enabling numerous novel applications in the future. This special issue, consisting of 2 reviews and 10 research articles, intends to explore the possible materials that could define next-generation 3D printing.

CMC`s research in Europe and the future potential of CMC`s in industry

DOE Office of Scientific and Technical Information (OSTI.GOV)

Van de Voorde, M.H.; Nedele, M.R.

1996-12-31

CMC`s (Ceramics Matrix Composites) have been developed for high temperature applications in aerospace and military industries. In general, the CMC`s should be capable of outperforming the best available superalloys. Great efforts are being given to pinpoint spin-off technologies i.e. applications in modern fossil fuel power plants, gas turbines, petrochemistry etc. In these applications, the CMC`s have to operate at temperatures up to 1400{degrees}C, in corrosive environments for long durations. These developments will provoke a breakthrough for this new group of CMC-materials. The paper will: (i) give an overview of the CMC`s research in Europe; processing, and characterization of physical, chemicalmore » and engineering properties at high temperatures; (ii) pinpoint the R&D needs to achieve the potential growth; and (iii) review the industrial potentials.« less

Ionic liquid propellants: future fuels for space propulsion.

PubMed

Zhang, Qinghua; Shreeve, Jean'ne M

2013-11-11

Use of green propellants is a trend for future space propulsion. Hypergolic ionic liquid propellants, which are environmentally-benign while exhibiting energetic performances comparable to hydrazine, have shown great potential to meet the requirements of developing nontoxic high-performance propellant formulations for space propulsion applications. This Concept article presents a review of recent advances in the field of ionic liquid propellants. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Dynamic Eye gaze and its Potential in Virtual Reality Based Applications for Children with Autism Spectrum Disorders.

PubMed

Lahiri, Uttama; Trewyn, Adam; Warren, Zachary; Sarkar, Nilanjan

2011-01-01

Children with Autism Spectrum Disorder are often characterized by deficits in social communication skills. While evidence suggests that intensive individualized interventions can improve aspects of core deficits in Autism Spectrum Disorder, at present numerous potent barriers exist related to accessing and implementing such interventions. Researchers are increasingly employing technology to develop more accessible, quantifiable, and individualized intervention tools to address core vulnerabilities related to autism. The present study describes the development and preliminary application of a Virtual Reality technology aimed at facilitating improvements in social communication skills for adolescents with autism. We present preliminary data from the usability study of this technological application for six adolescents with autism and discuss potential future development and application of adaptive Virtual Reality technology within an intervention framework.

Propolis: A natural biomaterial for dental and oral healthcare

PubMed Central

Khurshid, Zohaib; Naseem, Mustafa; Najeeb, Shariq; Zohaib, Sana

2017-01-01

The field of health has always emphasised on the use of natural products for curing diseases. There are varieties of natural products (such as silk, herbal tea, chitosan) used today in the biomedical application in treating a large array of systemic diseases. The natural product "Propolis" is a non-toxic resinous material having beneficial properties such as antimicrobial, anticancer, antifungal, antiviral and anti-inflammatory; hence gain the attention of researchers for its potential for bio-dental applications. The study aims to explore the properties and chemistry of propolis concerning biomedical and dental applications. In addition, status and scope of propolis for current and potential future in bio-dental applications have been discussed. This review gives an insight to the reader about the possible use of propolis in modern-day dentistry. PMID:29354255

Increasing the realism of projected tree species ranges by incorporating migration potential: an eastern US case study

NASA Astrophysics Data System (ADS)

Rogers, B. M.; Jantz, P.; Goetz, S. J.

2015-12-01

Models of vegetation distributions are used for a wide variety of purposes, from global assessments of biome shifts and biogeochemical feedbacks to local management planning. Dynamic vegetation models, mostly mechanistic in origin, are valuable for regional to global studies but remain limited for more local-scale applications, especially those that require species-specific responses to climate change. Species distribution models (SDMs) are broadly used for such applications, but these too have several outstanding limitations, one of the most prominent being a lack of dispersal and migration. Several hybrid models have recently been developed, but these generally require detailed parameterization of species-level attributes that may not be known. Here we present an approach to couple migration potential with SDM output for a large number of species in order to more realistically project future range shifts. We focus on 40 tree species in the eastern US of potential management concern, either because of their canopy dominance, ecosystem functions, or potential for utilizing future climates. Future climates were taken from a CMIP5 model ensemble average using RCP 4.5 and 8.5 scenarios. We used Random Forests to characterize current and future environmental suitability, and modeled migration as a negative exponential kernel that is affected by forest fragmentation and the density of current seed sources. We present results in a vulnerability framework relevant for a number of ongoing management activities in the region. We find an overarching pattern of northward and eastward range shifts, with high-elevation and northern species being the most adversely impacted. Because of limitations to migration, many newly suitable areas could not be utilized without active intervention. Only a few areas exhibited consistently favorable conditions that could be utilized by the relevant species, including the central Appalachian foothills and the Florida panhandle. We suggest that a continued effort to include migration potential into vegetation models can lead to more realistic results and management-relevant products.

CRISPR technologies for bacterial systems: Current achievements and future directions.

PubMed

Choi, Kyeong Rok; Lee, Sang Yup

2016-11-15

Throughout the decades of its history, the advances in bacteria-based bio-industries have coincided with great leaps in strain engineering technologies. Recently unveiled clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated proteins (Cas) systems are now revolutionizing biotechnology as well as biology. Diverse technologies have been derived from CRISPR/Cas systems in bacteria, yet the applications unfortunately have not been actively employed in bacteria as extensively as in eukaryotic organisms. A recent trend of engineering less explored strains in industrial microbiology-metabolic engineering, synthetic biology, and other related disciplines-is demanding facile yet robust tools, and various CRISPR technologies have potential to cater to the demands. Here, we briefly review the science in CRISPR/Cas systems and the milestone inventions that enabled numerous CRISPR technologies. Next, we describe CRISPR/Cas-derived technologies for bacterial strain development, including genome editing and gene expression regulation applications. Then, other CRISPR technologies possessing great potential for industrial applications are described, including typing and tracking of bacterial strains, virome identification, vaccination of bacteria, and advanced antimicrobial approaches. For each application, we note our suggestions for additional improvements as well. In the same context, replication of CRISPR/Cas-based chromosome imaging technologies developed originally in eukaryotic systems is introduced with its potential impact on studying bacterial chromosomal dynamics. Also, the current patent status of CRISPR technologies is reviewed. Finally, we provide some insights to the future of CRISPR technologies for bacterial systems by proposing complementary techniques to be developed for the use of CRISPR technologies in even wider range of applications. Copyright © 2016. Published by Elsevier Inc.

Chemical Mixtures and Epidemiologic Fundamentals for Risk Assessment Applications

EPA Science Inventory

Risk management options are increasingly being considered early in the risk assessment process to help scope the considerations and bound the inherent complexities related to potential exposures, risk and future clean-up decisions (including acceptable pollutant levels) related t...

[Ecological memory and its potential applications in ecology: a review].

PubMed

Sun, Zhong-yu; Ren, Hai

2011-03-01

Ecological memory (EM) is defined as the capability of the past states or experiences of a community to influence the present or future ecological responses of the community. As a relatively new concept, EM has received considerable attention in the study of ecosystem structure and function, such as community succession, ecological restoration, biological invasion, and natural resource management. This review summarized the definition, components, and categories of EM, and discussed the possible mechanisms and affecting factors of EM. Also, the potential applications of EM were proposed, in order to further understand the mechanisms of community succession and to guide ecological restoration.

Evaluation of heat engine for hybrid vehicle application

NASA Technical Reports Server (NTRS)

Schneider, H. W.

1984-01-01

The status of ongoing heat-engine developments, including spark-ignition, compression-ignition, internal-combustion, and external-combustion engines is presented. The potential of engine concepts under consideration for hybrid vehicle use is evaluated, using self-imposed criteria for selection. The deficiencies of the engines currently being evaluated in hybrid vehicles are discussed. Focus is on recent research with two-stroke, rotary, and free-piston engines. It is concluded that these engine concepts have the most promising potential for future application in hybrid vehicles. Recommendations are made for analysis and experimentation to evaluate stop-start and transient emission behavior of recommended engine concepts.

Shape memory alloys: Properties and biomedical applications

NASA Astrophysics Data System (ADS)

Mantovani, Diego

2000-10-01

Shape memory alloys provide new insights for the design of biomaterials in bioengineering for the design of artificial organs and advanced surgical instruments, since they have specific characteristics and unusual properties. This article will examine (a) the four properties of shape memory alloys, (b) medical applications with high potential for improving the present and future quality of life, and (c) concerns regarding the biocom-patibility properties of nickel-titanium alloys. In particular, the long-term challenges of using shape memory alloys will be discussed, regarding corrosion and potential leakage of elements and ions that could be toxic to cells, tissues and organs.

Sleep Applications to Assess Sleep Quality.

PubMed

Fietze, Ingo

2016-12-01

This article highlights the potential uses that smartphone applications may have for helping those with sleep problems. Applications in smartphones offer the promised possibility of detection of sleep. From the author's own experience, one can also conclude that sleep applications are approximately as good as polysomnography in detection of sleep time, similar to the conventional wearable actimeters. In the future, sleep applications will help to further enhance awareness of sleep health and to distinguish those who actually poorly and only briefly sleep from those who suffer more likely from paradox insomnia. Copyright © 2016 Elsevier Inc. All rights reserved.

Hollow fiber membranes for advanced life support systems. [permeable capillaries for medical filtration

NASA Technical Reports Server (NTRS)

Roebelen, G. J., Jr.; Lysaght, M. J.

1977-01-01

This paper describes an investigation of the practicability of utilizing hollow fiber membranes in vehicular and portable life support system applications. A preliminary screening of potential advanced life support applications resulted in the selection of five applications for feasibility study and testing. As a result of the feasibility study and testing, three applications, heat rejection, deaeration, and bacteria filtration, were chosen for breadboard development testing. Breadboard hardware has been manufactured and tested, and the physical properties of the three hollow fiber membrane assemblies applicable to use aboard future spacecraft have been characterized.

Stirling engine application study

NASA Technical Reports Server (NTRS)

Teagan, W. P.; Cunningham, D.

1983-01-01

A range of potential applications for Stirling engines in the power range from 0.5 to 5000 hp is surveyed. Over one hundred such engine applications are grouped into a small number of classes (10), with the application in each class having a high degree of commonality in technical performance and cost requirements. A review of conventional engines (usually spark ignition or Diesel) was then undertaken to determine the degree to which commercial engine practice now serves the needs of the application classes and to detemine the nature of the competition faced by a new engine system. In each application class the Stirling engine was compared to the conventional engines, assuming that objectives of ongoing Stirling engine development programs are met. This ranking process indicated that Stirling engines showed potential for use in all application classes except very light duty applications (lawn mowers, etc.). However, this potential is contingent on demonstrating much greater operating life and reliability than has been demonstrated to date by developmental Stirling engine systems. This implies that future program initiatives in developing Stirling engine systems should give more emphasis to life and reliability issues than has been the case in ongoing programs.

Electromagnetic Imaging Methods for Nondestructive Evaluation Applications

PubMed Central

Deng, Yiming; Liu, Xin

2011-01-01

Electromagnetic nondestructive tests are important and widely used within the field of nondestructive evaluation (NDE). The recent advances in sensing technology, hardware and software development dedicated to imaging and image processing, and material sciences have greatly expanded the application fields, sophisticated the systems design and made the potential of electromagnetic NDE imaging seemingly unlimited. This review provides a comprehensive summary of research works on electromagnetic imaging methods for NDE applications, followed by the summary and discussions on future directions. PMID:22247693

Atmospheric propagation issues relevant to optical communications

NASA Technical Reports Server (NTRS)

Churnside, James H.; Shaik, Kamran

1989-01-01

Atmospheric propagation issues relevant to space-to-ground optical communications for near-earth applications are studied. Propagation effects, current optical communication activities, potential applications, and communication techniques are surveyed. It is concluded that a direct-detection space-to-ground link using redundant receiver sites and temporal encoding is likely to be employed to transmit earth-sensing satellite data to the ground some time in the future. Low-level, long-term studies of link availability, fading statistics, and turbulence climatology are recommended to support this type of application.

Transonic Flow Computations Using Nonlinear Potential Methods

NASA Technical Reports Server (NTRS)

Holst, Terry L.; Kwak, Dochan (Technical Monitor)

2000-01-01

This presentation describes the state of transonic flow simulation using nonlinear potential methods for external aerodynamic applications. The presentation begins with a review of the various potential equation forms (with emphasis on the full potential equation) and includes a discussion of pertinent mathematical characteristics and all derivation assumptions. Impact of the derivation assumptions on simulation accuracy, especially with respect to shock wave capture, is discussed. Key characteristics of all numerical algorithm types used for solving nonlinear potential equations, including steady, unsteady, space marching, and design methods, are described. Both spatial discretization and iteration scheme characteristics are examined. Numerical results for various aerodynamic applications are included throughout the presentation to highlight key discussion points. The presentation ends with concluding remarks and recommendations for future work. Overall. nonlinear potential solvers are efficient, highly developed and routinely used in the aerodynamic design environment for cruise conditions. Published by Elsevier Science Ltd. All rights reserved.

A Potential Role for smallsats and Cubesats in Lunar Exploration

NASA Astrophysics Data System (ADS)

Carpenter, James; Fisackerly, Richard; Houdou, Bérengère; De Rosa, Diego; Schiemann, Jens D.; Walker, Roger; Zeppenfeldt, Frank

2015-04-01

The Moon is an important exploration destination for ESA, which is currently engaged in activities to access and exploit the Moon through developments in future human exploration systems and precursor robotic surface missions. However, recent major advancements in Smallsat and Cubesat technologies, and their application to fields such as Earth imaging and atmospheric science, has opened the possibility of utilising these smaller, lower cost platforms beyond LEO and potentially at the Moon. ESA is interested in understanding how emerging Smallsat & Cubesat instrument and platform technology could be applied to Lunar Exploration, particularly in the fields of technology demonstration and investigations which can be precursors to longer term l exploration activies. Lunar Cubesats can offer an means of access to the Moon, which complements larger ESA-led opportunities on international surface missions and via future human exploration systems. In this talk ESA will outline its current objectives in Lunar Exploration and highlight potential future opportunities for Smallsat and Cubesat platforms to play a role.

Theory of Gas Adsorption in Carbon Nanostructures

DTIC Science & Technology

2003-05-20

Johnson, "Histogram reweighting and finite size Scaling study of the Lennard - Jones fluids", Fluid Phase Equilibria, 187-188, 171-191 (2001). 19.Wei...nature of matter, with enormous potential for applications. The research continues, undiminished in intensity, in our laboratories and many others...pair potential is needed than the usually assumed free space interaction. These calculations suggest a few possible directions for future research

Scientific charge-coupled devices

NASA Technical Reports Server (NTRS)

Janesick, James R.; Elliott, Tom; Collins, Stewart; Blouke, Morley M.; Freeman, Jack

1987-01-01

The charge-coupled device dominates an ever-increasing variety of scientific imaging and spectroscopy applications. Recent experience indicates, however, that the full potential of CCD performance lies well beyond that realized in devices currently available.Test data suggest that major improvements are feasible in spectral response, charge collection, charge transfer, and readout noise. These properties, their measurement in existing CCDs, and their potential for future improvement are discussed in this paper.

Laccase applications in biofuels production: current status and future prospects.

PubMed

Kudanga, Tukayi; Le Roes-Hill, Marilize

2014-08-01

The desire to reduce dependence on the ever diminishing fossil fuel reserves coupled with the impetus towards green energy has seen increased research in biofuels as alternative sources of energy. Lignocellulose materials are one of the most promising feedstocks for advanced biofuels production. However, their utilisation is dependent on the efficient hydrolysis of polysaccharides, which in part is dependent on cost-effective and benign pretreatment of biomass to remove or modify lignin and release or expose sugars to hydrolytic enzymes. Laccase is one of the enzymes that are being investigated not only for potential use as pretreatment agents in biofuel production, mainly as a delignifying enzyme, but also as a biotechnological tool for removal of inhibitors (mainly phenolic) of subsequent enzymatic processes. The current review discusses the major advances in the application of laccase as a potential pretreatment strategy, the underlying principles as well as directions for future research in the search for better enzyme-based technologies for biofuel production. Future perspectives could include synergy between enzymes that may be required for optimal results and the adoption of the biorefinery concept in line with the move towards the global implementation of the bioeconomy strategy.

Deep Belief Networks for Electroencephalography: A Review of Recent Contributions and Future Outlooks.

PubMed

Movahedi, Faezeh; Coyle, James L; Sejdic, Ervin

2018-05-01

Deep learning, a relatively new branch of machine learning, has been investigated for use in a variety of biomedical applications. Deep learning algorithms have been used to analyze different physiological signals and gain a better understanding of human physiology for automated diagnosis of abnormal conditions. In this paper, we provide an overview of deep learning approaches with a focus on deep belief networks in electroencephalography applications. We investigate the state-of-the-art algorithms for deep belief networks and then cover the application of these algorithms and their performances in electroencephalographic applications. We covered various applications of electroencephalography in medicine, including emotion recognition, sleep stage classification, and seizure detection, in order to understand how deep learning algorithms could be modified to better suit the tasks desired. This review is intended to provide researchers with a broad overview of the currently existing deep belief network methodology for electroencephalography signals, as well as to highlight potential challenges for future research.

Radio Detection of Cosmic Rays-Achievements and Future Potential

NASA Astrophysics Data System (ADS)

Huege, Tim

When modern efforts for radio detection of cosmic rays started about a decade ago, hopes were high but the true potential was unknown. Since then, we have achieved a detailed understanding of the radio emission physics and have consequently succeeded in developing sophisticated detection schemes and analysis approaches. In particular, we have demonstrated that the important air-shower parameters arrival direction, particle energy and depth of shower maximum can be reconstructed reliably from radio measurements, with a precision that is comparable with that of other detection techniques. At the same time, limitations inherent to the radio-emission mechanisms have become apparent. In this article, I shortly review the capabilities of radio detection in the very high-frequency band, and discuss the potential for future application in existing and new experiments for cosmic-ray detection.

Potential Use of Human Periapical Cyst-Mesenchymal Stem Cells (hPCy-MSCs) as a Novel Stem Cell Source for Regenerative Medicine Applications

PubMed Central

Tatullo, Marco; Codispoti, Bruna; Pacifici, Andrea; Palmieri, Francesca; Marrelli, Massimo; Pacifici, Luciano; Paduano, Francesco

2017-01-01

Mesenchymal stem cells (MSCs) are attracting growing interest by the scientific community due to their huge regenerative potential. Thus, the plasticity of MSCs strongly suggests the utilization of these cells for regenerative medicine applications. The main issue about the clinical use of MSCs is related to the complex way to obtain them from healthy tissues; this topic has encouraged scientists to search for novel and more advantageous sources of these cells in easily accessible tissues. The oral cavity hosts several cell populations expressing mesenchymal stem cell like-features, furthermore, the access to oral and dental tissues is simple and isolation of cells is very efficient. Thus, oral-derived stem cells are highly attractive for clinical purposes. In this context, human periapical cyst mesenchymal stem cells (hPCy-MSCs) exhibit characteristics similar to other dental-derived MSCs, including their extensive proliferative potential, cell surface marker profile and the ability to differentiate into various cell types such as osteoblasts, adipocytes and neurons. Importantly, hPCy-MSCs are easily collected from the surgically removed periapical cysts; this reusing of biological waste guarantees a smart source of stem cells without any impact on the surrounding healthy tissues. In this review, we report the most interesting research topics related to hPCy-MSCs with a newsworthy discussion about the future insights. This newly discovered cell population exhibits interesting and valuable potentialities that could be of high impact in the future regenerative medicine applications. PMID:29259970

Potential Use of Human Periapical Cyst-Mesenchymal Stem Cells (hPCy-MSCs) as a Novel Stem Cell Source for Regenerative Medicine Applications.

PubMed

Tatullo, Marco; Codispoti, Bruna; Pacifici, Andrea; Palmieri, Francesca; Marrelli, Massimo; Pacifici, Luciano; Paduano, Francesco

2017-01-01

Mesenchymal stem cells (MSCs) are attracting growing interest by the scientific community due to their huge regenerative potential. Thus, the plasticity of MSCs strongly suggests the utilization of these cells for regenerative medicine applications. The main issue about the clinical use of MSCs is related to the complex way to obtain them from healthy tissues; this topic has encouraged scientists to search for novel and more advantageous sources of these cells in easily accessible tissues. The oral cavity hosts several cell populations expressing mesenchymal stem cell like-features, furthermore, the access to oral and dental tissues is simple and isolation of cells is very efficient. Thus, oral-derived stem cells are highly attractive for clinical purposes. In this context, human periapical cyst mesenchymal stem cells (hPCy-MSCs) exhibit characteristics similar to other dental-derived MSCs, including their extensive proliferative potential, cell surface marker profile and the ability to differentiate into various cell types such as osteoblasts, adipocytes and neurons. Importantly, hPCy-MSCs are easily collected from the surgically removed periapical cysts; this reusing of biological waste guarantees a smart source of stem cells without any impact on the surrounding healthy tissues. In this review, we report the most interesting research topics related to hPCy-MSCs with a newsworthy discussion about the future insights. This newly discovered cell population exhibits interesting and valuable potentialities that could be of high impact in the future regenerative medicine applications.

Anticipating Forest and Range Land Development in Central Oregon (USA) for Landscape Analysis, with an Example Application Involving Mule Deer

NASA Astrophysics Data System (ADS)

Kline, Jeffrey D.; Moses, Alissa; Burcsu, Theresa

2010-05-01

Forest policymakers, public lands managers, and scientists in the Pacific Northwest (USA) seek ways to evaluate the landscape-level effects of policies and management through the multidisciplinary development and application of spatially explicit methods and models. The Interagency Mapping and Analysis Project (IMAP) is an ongoing effort to generate landscape-wide vegetation data and models to evaluate the integrated effects of disturbances and management activities on natural resource conditions in Oregon and Washington (USA). In this initial analysis, we characterized the spatial distribution of forest and range land development in a four-county pilot study region in central Oregon. The empirical model describes the spatial distribution of buildings and new building construction as a function of population growth, existing development, topography, land-use zoning, and other factors. We used the model to create geographic information system maps of likely future development based on human population projections to inform complementary landscape analyses underway involving vegetation, habitat, and wildfire interactions. In an example application, we use the model and resulting maps to show the potential impacts of future forest and range land development on mule deer ( Odocoileus hemionus) winter range. Results indicate significant development encroachment and habitat loss already in 2000 with development located along key migration routes and increasing through the projection period to 2040. The example application illustrates a simple way for policymakers and public lands managers to combine existing data and preliminary model outputs to begin to consider the potential effects of development on future landscape conditions.

Education in Environmental Remote Sensing: Potentials and Problems.

ERIC Educational Resources Information Center

Kiefer, Ralph W.; Lillesand, Thomas M.

1983-01-01

Discusses remote sensing principles and applications and the status and needs of remote sensing education in the United States. A summary of the fundamental policy issues that will determine remote sensing's future role in environmental and resource managements is included. (Author/BC)

Potential Applications of Zeolite Membranes in Reaction Coupling Separation Processes

PubMed Central

Daramola, Michael O.; Aransiola, Elizabeth F.; Ojumu, Tunde V.

2012-01-01

Future production of chemicals (e.g., fine and specialty chemicals) in industry is faced with the challenge of limited material and energy resources. However, process intensification might play a significant role in alleviating this problem. A vision of process intensification through multifunctional reactors has stimulated research on membrane-based reactive separation processes, in which membrane separation and catalytic reaction occur simultaneously in one unit. These processes are rather attractive applications because they are potentially compact, less capital intensive, and have lower processing costs than traditional processes. Therefore this review discusses the progress and potential applications that have occurred in the field of zeolite membrane reactors during the last few years. The aim of this article is to update researchers in the field of process intensification and also provoke their thoughts on further research efforts to explore and exploit the potential applications of zeolite membrane reactors in industry. Further evaluation of this technology for industrial acceptability is essential in this regard. Therefore, studies such as techno-economical feasibility, optimization and scale-up are of the utmost importance.

Potential use and perspectives of nitric oxide donors in agriculture.

PubMed

Marvasi, Massimiliano

2017-03-01

Nitric oxide (NO) has emerged in the last 30 years as a key molecule involved in many physiological processes in plants, animals and bacteria. Current research has shown that NO can be delivered via donor molecules. In such cases, the NO release rate is dependent on the chemical structure of the donor itself and on the chemical environment. Despite NO's powerful signaling effect in plants and animals, the application of NO donors in agriculture is currently not implemented and research remains mainly at the experimental level. Technological development in the field of NO donors is rapidly expanding in scope to include controlling seed germination, plant development, ripening and increasing shelf-life of produce. Potential applications in animal production have also been identified. This concise review focuses on the use of donors that have shown potential biotechnological applications in agriculture. Insights are provided into (i) the role of donors in plant production, (ii) the potential use of donors in animal production and (iii) future approaches to explore the use and applications of donors for the benefit of agriculture. © 2016 Society of Chemical Industry. © 2016 Society of Chemical Industry.

Potential impacts of nanotechnology on energy transmission applications and needs.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Elcock, D.; Environmental Science Division

2007-11-30

The application of nanotechnologies to energy transmission has the potential to significantly impact both the deployed transmission technologies and the need for additional development. This could be a factor in assessing environmental impacts of right-of-way (ROW) development and use. For example, some nanotechnology applications may produce materials (e.g., cables) that are much stronger per unit volume than existing materials, enabling reduced footprints for construction and maintenance of electricity transmission lines. Other applications, such as more efficient lighting, lighter-weight materials for vehicle construction, and smaller batteries having greater storage capacities may reduce the need for long-distance transport of energy, and possiblymore » reduce the need for extensive future ROW development and many attendant environmental impacts. This report introduces the field of nanotechnology, describes some of the ways in which processes and products developed with or incorporating nanomaterials differ from traditional processes and products, and identifies some examples of how nanotechnology may be used to reduce potential ROW impacts. Potential environmental, safety, and health impacts are also discussed.« less

Development and Potential Applications of CRISPR-Cas9 Genome Editing Technology in Sarcoma

PubMed Central

Liu, Tang; Shen, Jacson K.; Li, Zhihong; Choy, Edwin; Hornicek, Francis J.; Duan, Zhenfeng

2016-01-01

Sarcomas include some of the most aggressive tumors and typically respond poorly to chemotherapy. In recent years, specific gene fusion/mutations and gene over-expression/activation have been shown to drive sarcoma pathogenesis and development. These emerging genomic alterations may provide targets for novel therapeutic strategies and have the potential to transform sarcoma patient care. The RNA-guided nuclease CRISPR-Cas9 (Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-associated protein-9 nuclease) is a convenient and versatile platform for site-specific genome editing and epigenome targeted modulation. Given that sarcoma is believed to develop as a result of genetic alterations in mesenchymal progenitor/stem cells, CRISPR-Cas9 genome editing technologies hold extensive application potentials in sarcoma models and therapies. We review the development and mechanisms of the CRISPR-Cas9 system in genome editing and introduce its application in sarcoma research and potential therapy in clinic. Additionally, we propose future directions and discuss the challenges faced with these applications, providing concise and enlightening information for readers interested in this area. PMID:26806808

Development and potential applications of CRISPR-Cas9 genome editing technology in sarcoma.

PubMed

Liu, Tang; Shen, Jacson K; Li, Zhihong; Choy, Edwin; Hornicek, Francis J; Duan, Zhenfeng

2016-04-01

Sarcomas include some of the most aggressive tumors and typically respond poorly to chemotherapy. In recent years, specific gene fusion/mutations and gene over-expression/activation have been shown to drive sarcoma pathogenesis and development. These emerging genomic alterations may provide targets for novel therapeutic strategies and have the potential to transform sarcoma patient care. The RNA-guided nuclease CRISPR-Cas9 (Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-associated protein-9 nuclease) is a convenient and versatile platform for site-specific genome editing and epigenome targeted modulation. Given that sarcoma is believed to develop as a result of genetic alterations in mesenchymal progenitor/stem cells, CRISPR-Cas9 genome editing technologies hold extensive application potentials in sarcoma models and therapies. We review the development and mechanisms of the CRISPR-Cas9 system in genome editing and introduce its application in sarcoma research and potential therapy in clinic. Additionally, we propose future directions and discuss the challenges faced with these applications, providing concise and enlightening information for readers interested in this area. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

Preliminary Evaluation Of Commercial Supercapacitors For Space Applications

NASA Astrophysics Data System (ADS)

Gineste, Valery; Loup, Didier; Mattesco, Patrick; Neugnot, Nicolas

2011-10-01

Supercapacitors are identified since years as a new technology enabling energy storage together with high power delivery capability to the system. A recent ESA study [1] led by Astrium has demonstrated the interest of these devices for space application, providing that reliability and end of life performances are demonstrated. A realistic commercial on the shelf (COTS) approach (or with limited design modification approved by potential suppliers) has been favoured (as for batteries). This paper presents preliminary test results done by Astrium on COTS supercapacitors: accelerated life tests, calendar life tests, technology analyses. Based on these results, assessment and lessons learnt are drawn in view of future exhaustive supercapacitor validation and future qualification.

What is "neuromarketing"? A discussion and agenda for future research.

PubMed

Lee, Nick; Broderick, Amanda J; Chamberlain, Laura

2007-02-01

Recent years have seen advances in neuroimaging to such an extent that neuroscientists are able to directly study the frequency, location, and timing of neuronal activity to an unprecedented degree. However, marketing science has remained largely unaware of such advances and their huge potential. In fact, the application of neuroimaging to market research--what has come to be called "neuromarketing"--has caused considerable controversy within neuroscience circles in recent times. This paper is an attempt to widen the scope of neuromarketing beyond commercial brand and consumer behaviour applications, to include a wider conceptualisation of marketing science. Drawing from general neuroscience and neuroeconomics, neuromarketing as a field of study is defined, and some future research directions are suggested.

Genetics of ischemic stroke: future clinical applications.

PubMed

Wang, Michael M

2006-11-01

Ischemic stroke has long been thought to have a genetic component that is independent of conventional vascular risk factors. It has been estimated that over one half of stroke risk is determined by inherited genes. However, until recently, strong evidence of genetic influence on ischemic stroke has been subject to criticism because the risk factors for stroke are also inherited and because previous studies suffered from limitations imposed by this highly heterogeneous neurological disorder. Recent advances in molecular genetics have led to the identification of specific genetic loci that impart susceptibility to ischemic stroke. We review the studies of these genes and discuss the future potential applications of genetic markers on the management of ischemic stroke patients.

Injectable Hydrogels for Cardiac Tissue Repair after Myocardial Infarction

PubMed Central

Khattab, Ahmad; Islam, Mohammad Ariful; Hweij, Khaled Abou; Zeitouny, Joya; Waters, Renae; Sayegh, Malek; Hossain, Md Monowar; Paul, Arghya

2015-01-01

Cardiac tissue damage due to myocardial infarction (MI) is one of the leading causes of mortality worldwide. The available treatments of MI include pharmaceutical therapy, medical device implants, and organ transplants, all of which have severe limitations including high invasiveness, scarcity of donor organs, thrombosis or stenosis of devices, immune rejection, and prolonged hospitalization time. Injectable hydrogels have emerged as a promising solution for in situ cardiac tissue repair in infarcted hearts after MI. In this review, an overview of various natural and synthetic hydrogels for potential application as injectable hydrogels in cardiac tissue repair and regeneration is presented. The review starts with brief discussions about the pathology of MI, its current clinical treatments and their limitations, and the emergence of injectable hydrogels as a potential solution for post MI cardiac regeneration. It then summarizes various hydrogels, their compositions, structures and properties for potential application in post MI cardiac repair, and recent advancements in the application of injectable hydrogels in treatment of MI. Finally, the current challenges associated with the clinical application of injectable hydrogels to MI and their potential solutions are discussed to help guide the future research on injectable hydrogels for translational therapeutic applications in regeneration of cardiac tissue after MI. PMID:27668147

Telehealth Innovations in Health Education and Training

PubMed Central

De, Suvranu; Hall, Richard W.; Johansen, Edward; Meglan, Dwight; Peng, Grace C.Y.

2010-01-01

Abstract Telehealth applications are increasingly important in many areas of health education and training. In addition, they will play a vital role in biomedical research and research training by facilitating remote collaborations and providing access to expensive/remote instrumentation. In order to fulfill their true potential to leverage education, training, and research activities, innovations in telehealth applications should be fostered across a range of technology fronts, including online, on-demand computational models for simulation; simplified interfaces for software and hardware; software frameworks for simulations; portable telepresence systems; artificial intelligence applications to be applied when simulated human patients are not options; and the development of more simulator applications. This article presents the results of discussion on potential areas of future development, barries to overcome, and suggestions to translate the promise of telehealth applications into a transformed environment of training, education, and research in the health sciences. PMID:20155874

Future Roles for Autonomous Vertical Lift in Disaster Relief and Emergency Response

NASA Technical Reports Server (NTRS)

Young, Larry A.

2006-01-01

System analysis concepts are applied to the assessment of potential collaborative contributions of autonomous system and vertical lift (a.k.a. rotorcraft, VTOL, powered-lift, etc.) technologies to the important, and perhaps underemphasized, application domain of disaster relief and emergency response. In particular, an analytic framework is outlined whereby system design functional requirements for an application domain can be derived from defined societal good goals and objectives.

Special Issue: NextGen Materials for 3D Printing

PubMed Central

Yeong, Wai Yee

2018-01-01

Only a handful of materials are well-established in three-dimensional (3D) printing and well-accepted in industrial manufacturing applications. However, recent advances in 3D printable materials have shown potential for enabling numerous novel applications in the future. This special issue, consisting of 2 reviews and 10 research articles, intends to explore the possible materials that could define next-generation 3D printing. PMID:29617311

Multidimensional modulation for next-generation transmission systems

NASA Astrophysics Data System (ADS)

Millar, David S.; Koike-Akino, Toshiaki; Kojima, Keisuke; Parsons, Kieran

2017-01-01

Recent research in multidimensional modulation has shown great promise in long reach applications. In this work, we will investigate the origins of this gain, the different approaches to multidimensional constellation design, and different performance metrics for coded modulation. We will also discuss the reason that such coded modulation schemes seem to have limited application at shorter distances, and the potential for other coded modulation schemes in future transmission systems.

The development of Nb-based advanced intermetallic alloys for structural applications

NASA Astrophysics Data System (ADS)

Subramanian, P. R.; Mendiratta, M. G.; Dimiduk, D. M.

1996-01-01

A new generation of refractory material systems with significant increases in temperature capability is required to meet the demands of future aerospace applications. Such materials require a balance of properties such as low-temperature damage tolerance, high-temperature strength, creep resistance, and superior environmental stability for implementation in advanced aerospace systems. Systems incorporating niobium-based beta alloys and intermetallic compounds have the potential for meeting these requirements.

Elastography: current status, future prospects, and making it work for you.

PubMed

Garra, Brian S

2011-09-01

Elastography has emerged as a useful adjunct tool for ultrasound diagnosis. Elastograms are images of tissue stiffness and may be in color, grayscale, or a combination of the two. The first and most common application of elastography is for the diagnosis of breast lesions where studies have shown an area under the receiver operating characteristic curve of 0.88 to 0.95 for distinguishing cancer from benign lesions. The technique is also useful for the diagnosis of complex cysts, although different scanners may vary in how they display such lesions. Recent advances in elastography include quantification using strain ratios, acoustic radiation force impulse imaging, and shear wave velocity estimation. These are useful not only for characterizing focal masses but also for diagnosing diffuse organ diseases such as liver cirrhosis. Other near term potential applications for elastography include characterization of thyroid nodules and lymph node evaluation for metastatic disease. Prostate cancer detection is also a potential application, but obtaining high-quality elastograms may be difficult. This area is evolving. Other promising applications include atheromatous plaque and arterial wall evaluation, venous thrombus evaluation, graft rejection, and monitoring of tumor ablation therapy. When contemplating the acquisition of a system with elastography in this rapidly evolving field, a clear picture of the manufacturer's plans for future upgrades (including quantification) should be obtained.

Air Traffic Management: Civil/Military Systems and Technologies.

DTIC Science & Technology

1980-02-01

consi-~derably Anthropo- Fig. 8 Increas of System Capcity versus Usable Gain in Traffic Flow Controllable ul R 5. The Future of ATC If we think of...years from 2,000 on we must think of an integrated system, integrating * the ATC-system of the Structure X (Fig. 7) * the aircraft, by improving flight...both civil and military traffic with a range of potential link applications and other information that could be helpful in their future thinking . No

Spirulina in Clinical Practice: Evidence-Based Human Applications

PubMed Central

Karkos, P. D.; Leong, S. C.; Karkos, C. D.; Sivaji, N.; Assimakopoulos, D. A.

2011-01-01

Spirulina or Arthrospira is a blue-green alga that became famous after it was successfully used by NASA as a dietary supplement for astronauts on space missions. It has the ability to modulate immune functions and exhibits anti-inflammatory properties by inhibiting the release of histamine by mast cells. Multiple studies investigating the efficacy and the potential clinical applications of Spirulina in treating several diseases have been performed and a few randomized controlled trials and systematic reviews suggest that this alga may improve several symptoms and may even have an anticancer, antiviral and antiallergic effects. Current and potential clinical applications, issues of safety, indications, side-effects and levels of evidence are addressed in this review. Areas of ongoing and future research are also discussed. PMID:18955364

The present and future of nanotechnology in human health care.

PubMed

Sahoo, S K; Parveen, S; Panda, J J

2007-03-01

Nanotechnology is a multidisciplinary field that covers a vast and diverse array of devices derived from engineering, physics, chemistry, and biology. The burgeoning new field of nanotechnology, opened up by rapid advances in science and technology, creates myriad new opportunities for advancing medical science and disease treatment in human health care. Applications of nanotechnology to medicine and physiology imply materials and devices designed to interact with the body at subcellular (i.e., molecular) scales with a high degree of specificity. This can be potentially translated into targeted cellular and tissue-specific clinical applications designed to achieve maximal therapeutic efficacy with minimal side effects. In this review the chief scientific and technical aspects of nanotechnology are introduced, and some of its potential clinical applications are discussed.

Novel Applications of Metabolomics in Personalized Medicine: A Mini-Review.

PubMed

Li, Bingbing; He, Xuyun; Jia, Wei; Li, Houkai

2017-07-13

Interindividual variability in drug responses and disease susceptibility is common in the clinic. Currently, personalized medicine is highly valued, the idea being to prescribe the right medicine to the right patient. Metabolomics has been increasingly applied in evaluating the therapeutic outcomes of clinical drugs by correlating the baseline metabolic profiles of patients with their responses, i.e., pharmacometabonomics, as well as prediction of disease susceptibility among population in advance, i.e., patient stratification. The accelerated advance in metabolomics technology pinpoints the huge potential of its application in personalized medicine. In current review, we discussed the novel applications of metabolomics with typical examples in evaluating drug therapy and patient stratification, and underlined the potential of metabolomics in personalized medicine in the future.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hendon, Christopher H.; Rieth, Adam J.; Korzyński, Maciej D.

Metal–organic frameworks (MOFs) allow compositional and structural diversity beyond conventional solid-state materials. Continued interest in the field is justified by potential applications of exceptional breadth, ranging from gas storage and separation, which takes advantage of the inherent pores and their volume, to electronic applications, which requires precise control of electronic structure. In this Outlook we present some of the pertinent challenges that MOFs face in their conventional implementations, as well as opportunities in less traditional areas. Here the aim is to discuss select design concepts and future research goals that emphasize nuances relevant to this class of materials as amore » whole. Particular emphasis is placed on synthetic aspects, as they influence the potential for MOFs in gas separation, electrical conductivity, and catalytic applications.« less

The role of oxytocin in relationships between dogs and humans and potential applications for the treatment of separation anxiety in dogs.

PubMed

Thielke, Lauren E; Udell, Monique A R

2017-02-01

The hormone oxytocin plays an important role in attachment formation and bonding between humans and domestic dogs. Recent research has led to increased interest in potential applications for intranasal oxytocin to aid with the treatment of psychological disorders in humans. While a few studies have explored the effects of intranasally administered oxytocin on social cognition and social bonding in dogs, alternative applications have not yet been explored for the treatment of behavioural problems in this species. One potentially important application for intranasal oxytocin in dogs could be the treatment of separation anxiety, a common attachment disorder in dogs. Here we provide an overview of what is known about the role of oxytocin in the human-dog bond and canine separation anxiety, and discuss considerations for future research looking to integrate oxytocin into behavioural treatment based on recent findings from both the human and dog literature. © 2015 Cambridge Philosophical Society.

Enabling functional genomics with genome engineering

PubMed Central

Hilton, Isaac B.; Gersbach, Charles A.

2015-01-01

Advances in genome engineering technologies have made the precise control over genome sequence and regulation possible across a variety of disciplines. These tools can expand our understanding of fundamental biological processes and create new opportunities for therapeutic designs. The rapid evolution of these methods has also catalyzed a new era of genomics that includes multiple approaches to functionally characterize and manipulate the regulation of genomic information. Here, we review the recent advances of the most widely adopted genome engineering platforms and their application to functional genomics. This includes engineered zinc finger proteins, TALEs/TALENs, and the CRISPR/Cas9 system as nucleases for genome editing, transcription factors for epigenome editing, and other emerging applications. We also present current and potential future applications of these tools, as well as their current limitations and areas for future advances. PMID:26430154

Microbial biosurfactants as additives for food industries.

PubMed

Campos, Jenyffer Medeiros; Stamford, Tânia Lúcia Montenegro; Sarubbo, Leonie Asfora; de Luna, Juliana Moura; Rufino, Raquel Diniz; Banat, Ibrahim M

2013-01-01

Microbial biosurfactants with high ability to reduce surface and interfacial surface tension and conferring important properties such as emulsification, detergency, solubilization, lubrication and phase dispersion have a wide range of potential applications in many industries. Significant interest in these compounds has been demonstrated by environmental, bioremediation, oil, petroleum, food, beverage, cosmetic and pharmaceutical industries attracted by their low toxicity, biodegradability and sustainable production technologies. Despite having significant potentials associated with emulsion formation, stabilization, antiadhesive and antimicrobial activities, significantly less output and applications have been reported in food industry. This has been exacerbated by uneconomical or uncompetitive costing issues for their production when compared to plant or chemical counterparts. In this review, biosurfactants properties, present uses and potential future applications as food additives acting as thickening, emulsifying, dispersing or stabilising agents in addition to the use of sustainable economic processes utilising agro-industrial wastes as alternative substrates for their production are discussed. © 2013 American Institute of Chemical Engineers.

Cannabis, Cannabinoids, and Cerebral Metabolism: Potential Applications in Stroke and Disorders of the Central Nervous System.

PubMed

Latorre, Julius Gene S; Schmidt, Elena B

2015-09-01

No compound has generated more attention in both the scientific and recently in the political arena as much as cannabinoids. These diverse groups of compounds referred collectively as cannabinoids have both been vilified due to its dramatic and potentially harmful psychotropic effects and glorified due to its equally dramatic and potential application in a number of acute and chronic neurological conditions. Previously illegal to possess, cannabis, the plant where natural form of cannabinoids are derived, is now accepted in a growing number of states for medicinal purpose, and some even for recreational use, increasing opportunities for more scientific experimentation. The purpose of this review is to summarize the growing body of literature on cannabinoids and to present an overview of our current state of knowledge of the human endocannabinoid system in the hope of defining the future of cannabinoids and its potential applications in disorders of the central nervous system, focusing on stroke.

Nanotechnology applications in medicine and dentistry.

PubMed

Gupta, Jyoti

2011-05-01

Nanotechnology, or nanoscience, refers to the research and development of an applied science at the atomic, molecular, or macromolecular levels (i.e. molecular engineering, manufacturing). The prefix "nano" is defined as a unit of measurement in which the characteristic dimension is one billionth of a unit. Although the nanoscale is small in size, its potential is vast. As nanotechnology expands in other fields, clinicians, scientists, and manufacturers are working to discover the uses and advances in biomedical sciences. Applications of nanotechnology in medical and dental fields have only approached the horizon with opportunities and possibilities for the future that can only be limited by our imagination. This paper provides an early glimpse of nanotechnology applications in medicine and dentistry to illustrate their potentially far-reaching impacts on clinical practice. It also narrates the safety issues concerning nanotechnology applications. © 2011 Blackwell Publishing Asia Pty Ltd.

Advances in Perovskite Solar Cells

PubMed Central

Zuo, Chuantian; Bolink, Henk J.; Han, Hongwei; Huang, Jinsong

2016-01-01

Organolead halide perovskite materials possess a combination of remarkable optoelectronic properties, such as steep optical absorption edge and high absorption coefficients, long charge carrier diffusion lengths and lifetimes. Taken together with the ability for low temperature preparation, also from solution, perovskite‐based devices, especially photovoltaic (PV) cells have been studied intensively, with remarkable progress in performance, over the past few years. The combination of high efficiency, low cost and additional (non‐PV) applications provides great potential for commercialization. Performance and applications of perovskite solar cells often correlate with their device structures. Many innovative device structures were developed, aiming at large‐scale fabrication, reducing fabrication cost, enhancing the power conversion efficiency and thus broadening potential future applications. This review summarizes typical structures of perovskite solar cells and comments on novel device structures. The applications of perovskite solar cells are discussed. PMID:27812475

Gaps analysis for CD metrology beyond the 22nm node

NASA Astrophysics Data System (ADS)

Bunday, Benjamin; Germer, Thomas A.; Vartanian, Victor; Cordes, Aaron; Cepler, Aron; Settens, Charles

2013-04-01

This paper will examine the future for critical dimension (CD) metrology. First, we will present the extensive list of applications for which CD metrology solutions are needed, showing commonalities and differences among the various applications. We will then report on the expected technical limits of the metrology solutions currently being investigated by SEMATECH and others in the industry to address the metrology challenges of future nodes, including conventional CD scanning electron microscopy (CD-SEM) and optical critical dimension (OCD) metrology and new potential solutions such as He-ion microscopy (HeIM, sometimes elsewhere referred to as HIM), CD atomic force microscopy (CD-AFM), CD small-angle x-ray scattering (CD-SAXS), high-voltage scanning electron microscopy (HV-SEM), and other types. A technical gap analysis matrix will then be demonstrated, showing the current state of understanding of the future of the CD metrology space.

Genetic Engineering and Crop Production.

ERIC Educational Resources Information Center

Jones, Helen C.; Frost, S.

1991-01-01

With a spotlight upon current agricultural difficulties and environmental dilemmas, this paper considers both the extant and potential applications of genetic engineering with respect to crop production. The nonagricultural factors most likely to sway the impact of this emergent technology upon future crop production are illustrated. (JJK)

Novel Flexible Wearable Sensor Materials and Signal Processing for Vital Sign and Human Activity Monitoring.

PubMed

Servati, Amir; Zou, Liang; Wang, Z Jane; Ko, Frank; Servati, Peyman

2017-07-13

Advances in flexible electronic materials and smart textile, along with broad availability of smart phones, cloud and wireless systems have empowered the wearable technologies for significant impact on future of digital and personalized healthcare as well as consumer electronics. However, challenges related to lack of accuracy, reliability, high power consumption, rigid or bulky form factor and difficulty in interpretation of data have limited their wide-scale application in these potential areas. As an important solution to these challenges, we present latest advances in novel flexible electronic materials and sensors that enable comfortable and conformable body interaction and potential for invisible integration within daily apparel. Advances in novel flexible materials and sensors are described for wearable monitoring of human vital signs including, body temperature, respiratory rate and heart rate, muscle movements and activity. We then present advances in signal processing focusing on motion and noise artifact removal, data mining and aspects of sensor fusion relevant to future clinical applications of wearable technology.

The contribution of molecular genetics to the understanding and management of cancer: potential future applications and implications for nurses.

PubMed

Bradley, A N

1999-06-01

Cancer is an immense medical problem and as a cause of mortality it is second only to cardiovascular disease. Much of the current understanding of cancer is owed to epidemiologists who have discovered a number of causative factors implicated in its development. These causative factors can be divided into genetic, chemical, physical, viral, radiation, immune and hormonal factors. Further advances in understanding have been made over the past decade from contributions made by the field of molecular biology. From investigation and examination of the molecular processes involved in the development of cancer it is becoming increasingly clear that changes in the genetic material of the cell nuclei are the final common pathway to cancer, whatever the initial aetiology. This article will attempt to elucidate the contribution of molecular genetics to the understanding of the likely mechanisms of carcinogenesis, the management of cancer, potential future applications and directions and the implications for nurses arising from this relatively new and evolving field of knowledge.

Realizing the promises of marine biotechnology.

PubMed

Luiten, Esther E M; Akkerman, Ida; Koulman, Albert; Kamermans, Pauline; Reith, Hans; Barbosa, Maria J; Sipkema, Detmer; Wijffels, René H

2003-07-01

High-quality research in the field of marine biotechnology is one of the key-factors for successful innovation in exploiting the vast diversity of marine life. However, fascinating scientific research with promising results and claims on promising potential applications (e.g. for pharmaceuticals, nutritional supplements, (feed-)products for aquaculture and bioremediation solutions) is not the only factor to realise the commercial applications of marine biotechnology. What else is needed to exploit the promising potential of marine biotechnology and to create new industrial possibilities? In the study project 'Ocean Farming-Sustainable exploitation of marine organisms', we explore the possibilities of marine organisms to fulfill needs, such as safe and healthy food, industrial (raw) materials and renewable energy in a sustainable way. One of the three design groups is envisioning the future of strong land-based 'marine' market chains. Marine biotechnology is one of the foci of attention in this design group. This article provides a model of future-oriented thinking in which a variety of experts actively participate.

Clinical trial perspective for adult and juvenile Huntington's disease using genetically-engineered mesenchymal stem cells

PubMed Central

Deng, Peter; Torrest, Audrey; Pollock, Kari; Dahlenburg, Heather; Annett, Geralyn; Nolta, Jan A.; Fink, Kyle D.

2016-01-01

Progress to date from our group and others indicate that using genetically-engineered mesenchymal stem cells (MSC) to secrete brain-derived neurotrophic factor (BDNF) supports our plan to submit an Investigational New Drug application to the Food and Drug Administration for the future planned Phase 1 safety and tolerability trial of MSC/BDNF in patients with Huntington's disease (HD). There are also potential applications of this approach beyond HD. Our biological delivery system for BDNF sets the precedent for adult stem cell therapy in the brain and could potentially be modified for other neurodegenerative disorders such as amyotrophic lateral sclerosis (ALS), spinocerebellar ataxia (SCA), Alzheimer's disease, and some forms of Parkinson's disease. The MSC/BDNF product could also be considered for studies of regeneration in traumatic brain injury, spinal cord and peripheral nerve injury. This work also provides a platform for our future gene editing studies, since we will again use MSCs to deliver the needed molecules into the central nervous system. PMID:27335539

Micro-sized microbial fuel cell: a mini-review.

PubMed

Wang, Hsiang-Yu; Bernarda, Angela; Huang, Chih-Yung; Lee, Duu-Jong; Chang, Jo-Shu

2011-01-01

This review presents the development of micro-sized microbial fuel cells (including mL-scale and μL-scale setups), with summarization of their advantageous characteristics, fabrication methods, performances, potential applications and possible future directions. The performance of microbial fuel cells (MFCs) is affected by issues such as mass transport, reaction kinetics and ohmic resistance. These factors are manipulated in micro-sized MFCs using specially allocated electrodes constructed with specified materials having physically or chemically modified surfaces. Both two-chamber and air-breathing cathodes are promising configurations for mL-scale MFCs. However, most of the existing μL-scale MFCs generate significantly lower volumetric power density compared with their mL-counterparts because of the high internal resistance. Although μL-scale MFCs have not yet to provide sufficient power for operating conventional equipment, they show great potential in rapid screening of electrochemically microbes and electrode performance. Additional possible applications and future directions are also provided for the development of micro-sized MFCs. Copyright © 2010 Elsevier Ltd. All rights reserved.

Novel Flexible Wearable Sensor Materials and Signal Processing for Vital Sign and Human Activity Monitoring

PubMed Central

Servati, Amir; Wang, Z. Jane; Ko, Frank; Servati, Peyman

2017-01-01

Advances in flexible electronic materials and smart textile, along with broad availability of smart phones, cloud and wireless systems have empowered the wearable technologies for significant impact on future of digital and personalized healthcare as well as consumer electronics. However, challenges related to lack of accuracy, reliability, high power consumption, rigid or bulky form factor and difficulty in interpretation of data have limited their wide-scale application in these potential areas. As an important solution to these challenges, we present latest advances in novel flexible electronic materials and sensors that enable comfortable and conformable body interaction and potential for invisible integration within daily apparel. Advances in novel flexible materials and sensors are described for wearable monitoring of human vital signs including, body temperature, respiratory rate and heart rate, muscle movements and activity. We then present advances in signal processing focusing on motion and noise artifact removal, data mining and aspects of sensor fusion relevant to future clinical applications of wearable technology. PMID:28703744

Simulation of Halocarbon Production and Emissions and Effects on Ozone Depletion

PubMed

Holmes; Ellis

1997-09-01

/ This paper describes an integrated model that simulates future halocarbon production/emissions and potential ozone depletion. Applications and historical production levels for various halocarbons are discussed first. A framework is then presented for modeling future halocarbon impacts incorporating differences in underlying demands, applications, regulatory mandates, and environmental characteristics. The model is used to simulate the potential impacts of several prominent issues relating to halocarbon production, regulation, and environmental interactions, notably: changes in agricultural methyl bromide use, increases in effectiveness of bromine for ozone depletion, modifications to the elimination schedule for HCFCs, short-term expansion of CFC demand in low use compliance countries, and delays in Russian Federation compliance. Individually, each issue does not unequivocally represent a significant likely increase in long-term atmospheric halogen loading and stratospheric ozone depletion. In combination, however, these impacts could increase peak halogen concentrations and long-term integral halogen loading, resulting in higher levels of stratospheric ozone depletion and longer exposure to increased levels of UV radiation.KEY WORDS: Halocarbons; Ozone depletion; Montreal Protocol; Integrated assessment

Quantifying the risk posed by potential Earth impacts

NASA Technical Reports Server (NTRS)

Chesley, S. R.; Chodas, P. W.; Harris, A. W.; Milani, A.; Valsecchi, G. B.; Yeomans, D. K.

2001-01-01

Predictions of future potential Earth impacts by near-Earth objects (NEOs) have become commonplace in recent years, and the rate of these detections is likely to accelerate as asteroid survey efforts continue to mature. In this paper we describe the metrics introduced, and we give numerous examples of their application. This enables us to establish in rough terms the levels at which events become interesting to various parties.

Unified interatomic potential and energy barrier distributions for amorphous oxides.

PubMed

Trinastic, J P; Hamdan, R; Wu, Y; Zhang, L; Cheng, Hai-Ping

2013-10-21

Amorphous tantala, titania, and hafnia are important oxides for biomedical implants, optics, and gate insulators. Understanding the effects of oxide doping is crucial to optimize performance in these applications. However, no molecular dynamics potentials have been created to date that combine these and other oxides that would allow computational analyses of doping-dependent structural and mechanical properties. We report a novel set of computationally efficient, two-body potentials modeling van der Waals and covalent interactions that reproduce the structural and elastic properties of both pure and doped amorphous oxides. In addition, we demonstrate that the potential accurately produces energy barrier distributions for pure and doped samples. The distributions can be directly compared to experiment and used to calculate physical quantities such as internal friction to understand how doping affects material properties. Future analyses using these potentials will be of great value to determine optimal doping concentrations and material combinations for myriad material science applications.

Health Domains for Sale: The Need for Global Health Internet Governance

PubMed Central

Liang, Bryan A; Kohler, Jillian C; Attaran, Amir

2014-01-01

A debate on Internet governance for health, or “eHealth governance”, is emerging with the impending award of a new dot-health (.health) generic top-level domain name (gTLD) along with a host of other health-related domains. This development is critical as it will shape the future of the health Internet, allowing largely unrestricted use of .health second-level domain names by future registrants, raising concerns about the potential for privacy, use and marketing of health-related information, credibility of online health content, and potential for Internet fraud and abuse. Yet, prospective .health gTLD applicants do not provide adequate safeguards for use of .health or related domains and have few or no ties to the global health community. If approved, one of these for-profit corporate applicants would effectively control the future of the .health address on the Internet with arguably no active oversight from important international public health stakeholders. This would represent a lost opportunity for the public health, medical, and broader health community in establishing a trusted, transparent and reliable source for health on the Internet. Countries, medical associations, civil society, and consumer advocates have objected to these applications on grounds that they do not meet the public interest. We argue that there is an immediate need for action to postpone awarding of the .health gTLD and other health-related gTLDs to address these concerns and ensure the appropriate development of sound eHealth governance rules, principles, and use. This would support the crucial need of ensuring access to quality and evidence-based sources of health information online, as well as establishing a safe and reliable space on the Internet for health. We believe, if properly governed, .health and other domains could represent such a promise in the future. PMID:24598602

Health domains for sale: the need for global health Internet governance.

PubMed

Mackey, Tim Ken; Liang, Bryan A; Kohler, Jillian C; Attaran, Amir

2014-03-05

A debate on Internet governance for health, or "eHealth governance", is emerging with the impending award of a new dot-health (.health) generic top-level domain name (gTLD) along with a host of other health-related domains. This development is critical as it will shape the future of the health Internet, allowing largely unrestricted use of .health second-level domain names by future registrants, raising concerns about the potential for privacy, use and marketing of health-related information, credibility of online health content, and potential for Internet fraud and abuse. Yet, prospective .health gTLD applicants do not provide adequate safeguards for use of .health or related domains and have few or no ties to the global health community. If approved, one of these for-profit corporate applicants would effectively control the future of the .health address on the Internet with arguably no active oversight from important international public health stakeholders. This would represent a lost opportunity for the public health, medical, and broader health community in establishing a trusted, transparent and reliable source for health on the Internet. Countries, medical associations, civil society, and consumer advocates have objected to these applications on grounds that they do not meet the public interest. We argue that there is an immediate need for action to postpone awarding of the .health gTLD and other health-related gTLDs to address these concerns and ensure the appropriate development of sound eHealth governance rules, principles, and use. This would support the crucial need of ensuring access to quality and evidence-based sources of health information online, as well as establishing a safe and reliable space on the Internet for health. We believe, if properly governed, .health and other domains could represent such a promise in the future.

A Vision of Quantitative Imaging Technology for Validation of Advanced Flight Technologies

NASA Technical Reports Server (NTRS)

Horvath, Thomas J.; Kerns, Robert V.; Jones, Kenneth M.; Grinstead, Jay H.; Schwartz, Richard J.; Gibson, David M.; Taylor, Jeff C.; Tack, Steve; Dantowitz, Ronald F.

2011-01-01

Flight-testing is traditionally an expensive but critical element in the development and ultimate validation and certification of technologies destined for future operational capabilities. Measurements obtained in relevant flight environments also provide unique opportunities to observe flow phenomenon that are often beyond the capabilities of ground testing facilities and computational tools to simulate or duplicate. However, the challenges of minimizing vehicle weight and internal complexity as well as instrumentation bandwidth limitations often restrict the ability to make high-density, in-situ measurements with discrete sensors. Remote imaging offers a potential opportunity to noninvasively obtain such flight data in a complementary fashion. The NASA Hypersonic Thermodynamic Infrared Measurements Project has demonstrated such a capability to obtain calibrated thermal imagery on a hypersonic vehicle in flight. Through the application of existing and accessible technologies, the acreage surface temperature of the Shuttle lower surface was measured during reentry. Future hypersonic cruise vehicles, launcher configurations and reentry vehicles will, however, challenge current remote imaging capability. As NASA embarks on the design and deployment of a new Space Launch System architecture for access beyond earth orbit (and the commercial sector focused on low earth orbit), an opportunity exists to implement an imagery system and its supporting infrastructure that provides sufficient flexibility to incorporate changing technology to address the future needs of the flight test community. A long term vision is offered that supports the application of advanced multi-waveband sensing technology to aid in the development of future aerospace systems and critical technologies to enable highly responsive vehicle operations across the aerospace continuum, spanning launch, reusable space access and global reach. Motivations for development of an Agency level imagery-based measurement capability to support cross cutting applications that span the Agency mission directorates as well as meeting potential needs of the commercial sector and national interests of the Intelligence, Surveillance and Reconnaissance community are explored. A recommendation is made for an assessment study to baseline current imaging technology including the identification of future mission requirements. Development of requirements fostered by the applications suggested in this paper would be used to identify technology gaps and direct roadmapping for implementation of an affordable and sustainable next generation sensor/platform system.

A survey of application: genomics and genetic programming, a new frontier.

PubMed

Khan, Mohammad Wahab; Alam, Mansaf

2012-08-01

The aim of this paper is to provide an introduction to the rapidly developing field of genetic programming (GP). Particular emphasis is placed on the application of GP to genomics. First, the basic methodology of GP is introduced. This is followed by a review of applications in the areas of gene network inference, gene expression data analysis, SNP analysis, epistasis analysis and gene annotation. Finally this paper concluded by suggesting potential avenues of possible future research on genetic programming, opportunities to extend the technique, and areas for possible practical applications. Copyright © 2012 Elsevier Inc. All rights reserved.

Status of the advanced Stirling conversion system project for 25 kW dish Stirling applications

NASA Technical Reports Server (NTRS)

Shaltens, Richard K.; Schreiber, Jeffrey G.

1991-01-01

Heat engines were evaluated for terrestrial Solar Distributed Heat Receivers. The Stirling engine was identified as one of the most promising heat engines for terrestrial applications. Technology development is also conducted for Stirling convertors directed toward a dynamic power source for space applications. Space power requirements include high reliability with very long life, low vibration, and high system efficiency. The free-piston Stirling engine has the potential for future high power space conversion systems, either nuclear or solar powered. Although both applications appear to be quite different, their requirements complement each other.

LWIR detector requirements for low-background space applications

NASA Technical Reports Server (NTRS)

Deluccia, Frank J.

1990-01-01

Detection of cold bodies (200 to 300 K) against space backgrounds has many important applications, both military and non-military. The detector performance and design characteristics required to support low-background applications are discussed, with particular emphasis on those characteristics required for space surveillance. The status of existing detector technologies under active development for these applications is also discussed. In order to play a role in future systems, new, potentially competing detector technologies such as multiple quantum well detectors must not only meet system-derived requirements, but also offer distinct performance or other advantages over these incumbent technologies.

BBU design of linear induction accelerator cells for radiography application

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shang, C.C.; Chen, Y.J.; Gaporaso, G.J.

1997-05-06

There is an ongoing effort to develop accelerating modules for high-current electron accelerators for advanced radiography application. Accelerating modules with low beam-cavity coupling impedances along with gap designs with acceptable field stresses comprise a set of fundamental design criteria. We examine improved cell designs which have been developed for accelerator application in several radiographic operating regimes. We evaluate interaction impedances, analyze the effects of beam structure coupling on beam dynamics (beam break-up instability and corkscrew motion). We also provide estimates of coupling through interesting new high-gradient insulators and evaluate their potential future application in induction cells.

Review and future prospects for DNA barcoding methods in forensic palynology.

PubMed

Bell, Karen L; Burgess, Kevin S; Okamoto, Kazufusa C; Aranda, Roman; Brosi, Berry J

2016-03-01

Pollen can be a critical forensic marker in cases where determining geographic origin is important, including investigative leads, missing persons cases, and intelligence applications. However, its use has previously been limited by the need for a high level of specialization by expert palynologists, slow speeds of identification, and relatively poor taxonomic resolution (typically to the plant family or genus level). By contrast, identification of pollen through DNA barcoding has the potential to overcome all three of these limitations, and it may seem surprising that the method has not been widely implemented. Despite what might seem a straightforward application of DNA barcoding to pollen, there are technical issues that have delayed progress. However, recent developments of standard methods for DNA barcoding of pollen, along with improvements in high-throughput sequencing technology, have overcome most of these technical issues. Based on these recent methodological developments in pollen DNA barcoding, we believe that now is the time to start applying these techniques in forensic palynology. In this article, we discuss the potential for these methods, and outline directions for future research to further improve on the technology and increase its applicability to a broader range of situations. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

Silk protein-based hydrogels: Promising advanced materials for biomedical applications.

PubMed

Kapoor, Sonia; Kundu, Subhas C

2016-02-01

Hydrogels are a class of advanced material forms that closely mimic properties of the soft biological tissues. Several polymers have been explored for preparing hydrogels with structural and functional features resembling that of the extracellular matrix. Favourable material properties, biocompatibility and easy processing of silk protein fibers into several forms make it a suitable material for biomedical applications. Hydrogels made from silk proteins have shown a potential in overcoming limitations of hydrogels prepared from conventional polymers. A great deal of effort has been made to control the properties and to integrate novel topographical and functional characteristics in the hydrogel composed from silk proteins. This review provides overview of the advances in silk protein-based hydrogels with a primary emphasis on hydrogels of fibroin. It describes the approaches used to fabricate fibroin hydrogels. Attempts to improve the existing properties or to incorporate new features in the hydrogels by making composites and by improving fibroin properties by genetic engineering approaches are also described. Applications of the fibroin hydrogels in the realms of tissue engineering and controlled release are reviewed and their future potentials are discussed. This review describes the potentiality of silk fibroin hydrogel. Silk Fibroin has been widely recognized as an interesting biomaterial. Due to its properties including high mechanical strength and excellent biocompatibility, it has gained wide attention. Several groups are exploring silk-based materials including films, hydrogels, nanofibers and nanoparticles for different biomedical applications. Although there is a good amount of literature available on general properties and applications of silk based biomaterials, there is an inadequacy of extensive review articles that specifically focus on silk based hydrogels. Silk-based hydrogels have a strong potential to be utilized in biomedical applications. Our work is an effort to highlight the research that has been done in the area of silk-based hydrogels. It aims to provide an overview of the advances that have been made and the future course available. It will provide an overview of the silk-based hydrogels as well as may direct the readers to the specific areas of application. Copyright © 2015 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.

InP (Indium Phosphide): Into the future

NASA Technical Reports Server (NTRS)

Brandhorst, Henry W., Jr.

1989-01-01

Major industry is beginning to be devoted to indium phosphide and its potential applications. Key to these applications are high speed and radiation tolerance; however the high cost of indium phosphide may be an inhibitor to progress. The broad applicability of indium phosphide to many devices will be discussed with an emphasis on photovoltaics. Major attention is devoted to radiation tolerance and means of reducing cost of devices. Some of the approaches applicable to solar cells may also be relevant to other devices. The intent is to display the impact of visionary leadership in the field and enable the directions and broad applicability of indium phosphide.

Activated Carbon Fibers For Gas Storage

DOE Office of Scientific and Technical Information (OSTI.GOV)

Burchell, Timothy D; Contescu, Cristian I; Gallego, Nidia C

The advantages of Activated Carbon Fibers (ACF) over Granular Activated Carbon (GAC) are reviewed and their relationship to ACF structure and texture are discussed. These advantages make ACF very attractive for gas storage applications. Both adsorbed natural gas (ANG) and hydrogen gas adsorption performance are discussed. The predicted and actual structure and performance of lignin-derived ACF is reviewed. The manufacture and performance of ACF derived monolith for potential automotive natural gas (NG) storage applications is reported Future trends for ACF for gas storage are considered to be positive. The recent improvements in NG extraction coupled with the widespread availability ofmore » NG wells means a relatively inexpensive and abundant NG supply in the foreseeable future. This has rekindled interest in NG powered vehicles. The advantages and benefit of ANG compared to compressed NG offer the promise of accelerated use of ANG as a commuter vehicle fuel. It is to be hoped the current cost hurdle of ACF can be overcome opening ANG applications that take advantage of the favorable properties of ACF versus GAC. Lastly, suggestions are made regarding the direction of future work.« less

Carbon Nanotubes as Optical Sensors in Biomedicine.

PubMed

Farrera, Consol; Torres Andón, Fernando; Feliu, Neus

2017-11-28

Single-walled carbon nanotubes (SWCNTs) have become potential candidates for a wide range of medical applications including sensing, imaging, and drug delivery. Their photophysical properties (i.e., the capacity to emit in the near-infrared), excellent photostability, and fluorescence, which is highly sensitive to the local environment, make SWCNTs promising optical probes in biomedicine. In this Perspective, we discuss the existing strategies for and challenges of using carbon nanotubes for medical diagnosis based on intracellular sensing as well as discuss also their biocompatibility and degradability. Finally, we highlight the potential improvements of this nanotechnology and future directions in the field of carbon nanotubes for biomedical applications.

Computational predictions of zinc oxide hollow structures

NASA Astrophysics Data System (ADS)

Tuoc, Vu Ngoc; Huan, Tran Doan; Thao, Nguyen Thi

2018-03-01

Nanoporous materials are emerging as potential candidates for a wide range of technological applications in environment, electronic, and optoelectronics, to name just a few. Within this active research area, experimental works are predominant while theoretical/computational prediction and study of these materials face some intrinsic challenges, one of them is how to predict porous structures. We propose a computationally and technically feasible approach for predicting zinc oxide structures with hollows at the nano scale. The designed zinc oxide hollow structures are studied with computations using the density functional tight binding and conventional density functional theory methods, revealing a variety of promising mechanical and electronic properties, which can potentially find future realistic applications.

Status of NASA In-Space Propulsion Technologies and Their Infusion Potential

NASA Technical Reports Server (NTRS)

Anderson, David; Pencil, Eric; Vento, Dan; Peterson, Todd; Dankanich, John; Hahne, David; Munk, Michelle

2011-01-01

Since 2001, the In-Space Propulsion Technology (ISPT) program has been developing in-space propulsion technologies that will enable or enhance NASA robotic science missions. These in-space propulsion technologies have broad applicability to future competed Discovery and New Frontiers mission solicitations, and are potentially enabling for future NASA flagship and sample return missions currently being considered. This paper provides status of the technology development of several in-space propulsion technologies that are ready for infusion into future missions. The technologies that are ready for flight infusion are: 1) the high-temperature Advanced Material Bipropellant Rocket (AMBR) engine providing higher performance; 2) NASA s Evolutionary Xenon Thruster (NEXT) ion propulsion system, a 0.6-7 kW throttle-able gridded ion system; and 3) Aerocapture technology development with investments in a family of thermal protection system (TPS) materials and structures; guidance, navigation, and control (GN&C) models of blunt-body rigid aeroshells; and aerothermal effect models. Two component technologies that will be ready for flight infusion in FY12/13 are 1) Advanced Xenon Flow Control System, and 2) ultra-lightweight propellant tank technology advancements and their infusion potential will be also discussed. The paper will also describe the ISPT project s future focus on propulsion for sample return missions: 1) Mars Ascent Vehicles (MAV); 2) multi-mission technologies for Earth Entry Vehicles (MMEEV) needed for sample return missions from many different destinations; and 3) electric propulsion for sample return and low cost missions. These technologies are more vehicle-focused, and present a different set of technology infusion challenges. Systems/Mission Analysis focused on developing tools and assessing the application of propulsion technologies to a wide variety of mission concepts.

The universality and the future prospects of physiological energetics: Reply to comments on "Physics of metabolic organization".

PubMed

Jusup, Marko; Sousa, Tânia; Domingos, Tiago; Labinac, Velimir; Marn, Nina; Wang, Zhen; Klanjšček, Tin

2017-03-01

In response to the comments on review "Physics of metabolic organization", we discuss the universality and the future prospects of physiological energetics. The topics range from the role of entropy in modeling living organisms to the apparent ubiquity of the von Bertalanffy curve, and the potential applications of the theory in yet unexplored domains. Tradeoffs in outreach to non-specialists are also briefly considered. Copyright © 2017 Elsevier B.V. All rights reserved.

MSFC Skylab Apollo Telescope Mount. [a technical history and management critique

NASA Technical Reports Server (NTRS)

Morse, A. R.

1974-01-01

A technical history and management critique of the Skylab Apollo Telescope Mount (ATM) from initial conception through the design, manufacturing, testing and prelaunch phases is presented. A mission performance summary provides a general overview of the ATM's achievements in relationship to its design goals. Recommendations and conclusions applicable to hardware design, test program philosophy and performance, and program management techniques for the ATM with potential application to future programs are also discussed.

Terahertz: the Far-Ir Challenge

NASA Astrophysics Data System (ADS)

Dispenza, Massimiliano; Fiorello, Annamaria; Secchi, Alberto; Varasi, Mauro

This chapter is an overview on terahertz technologies and applications for sensing. The most advanced imaging and spectroscopy techniques are described, considering current opportunities and limitations in comparison to probes in the adjacent regions of the e.m. spectrum. Potential applications are highlighted, with a specific focus on security for detection of illicit substances and revealing of hidden objects. The technological status and current bottlenecks on sources and detectors are reviewed and future trends discussed.

Paraffin-based hybrid rocket engines applications: A review and a market perspective

NASA Astrophysics Data System (ADS)

Mazzetti, Alessandro; Merotto, Laura; Pinarello, Giordano

2016-09-01

Hybrid propulsion technology for aerospace applications has received growing attention in recent years due to its important advantages over competitive solutions. Hybrid rocket engines have a great potential for several aeronautics and aerospace applications because of their safety, reliability, low cost and high performance. As a consequence, this propulsion technology is feasible for a number of innovative missions, including space tourism. On the other hand, hybrid rocket propulsion's main drawback, i.e. the difficulty in reaching high regression rate values using standard fuels, has so far limited the maturity level of this technology. The complex physico-chemical processes involved in hybrid rocket engines combustion are of major importance for engine performance prediction and control. Therefore, further investigation is ongoing in order to achieve a more complete understanding of such phenomena. It is well known that one of the most promising solutions for overcoming hybrid rocket engines performance limits is the use of liquefying fuels. Such fuels can lead to notably increased solid fuel regression rate due to the so-called "entrainment phenomenon". Among liquefying fuels, paraffin-based formulations have great potentials as solid fuels due to their low cost, availability (as they can be derived from industrial waste), low environmental impact and high performance. Despite the vast amount of literature available on this subject, a precise focus on market potential of paraffins for hybrid propulsion aerospace applications is lacking. In this work a review of hybrid rocket engines state of the art was performed, together with a detailed analysis of the possible applications of such a technology. A market study was carried out in order to define the near-future foreseeable development needs for hybrid technology application to the aforementioned missions. Paraffin-based fuels are taken into account as the most promising segment for market development.The present study is useful for driving future investigation and testing of paraffin-based fuels as solid fuels for hybrid propulsion technology, taking into account the needs of industrial applications of this technology.

Parameter estimation techniques and application in aircraft flight testing

NASA Technical Reports Server (NTRS)

1974-01-01

Technical papers presented at the symposium by selected representatives from industry, universities, and various Air Force, Navy, and NASA installations are given. The topics covered include the newest developments in identification techniques, the most recent flight-test experience, and the projected potential for the near future.

EVALUATION OF THE EFFECTS ON BENTHIC ORGANISMS FROM CLAY FLOCCULATION OF RED TIDE ORGANISMS

EPA Science Inventory

Evaluating the feasibility of controlling red tide using clay flocculation is part of an ECOHAB-funded project. One aspect for the feasibility and future application of clays is the determination of potential negative environmental impacts. The removal of toxin-containing dinofl...

Electrical chips for biological point-of-care detection

USDA-ARS?s Scientific Manuscript database

As the future of health care diagnostics moves toward more portable and personalized techniques, there is immense potential to harness the power of electrical signals for biological sensing and diagnostic applications at the point of care. Electrical biochips can be used to both manipulate and sense...

Magnetic hydroxyapatite: a promising multifunctional platform for nanomedicine application

PubMed Central

Mondal, Sudip; Manivasagan, Panchanathan; Bharathiraja, Subramaniyan; Santha Moorthy, Madhappan; Kim, Hye Hyun; Seo, Hansu; Lee, Kang Dae; Oh, Junghwan

2017-01-01

In this review, specific attention is paid to the development of nanostructured magnetic hydroxyapatite (MHAp) and its potential application in controlled drug/gene delivery, tissue engineering, magnetic hyperthermia treatment, and the development of contrast agents for magnetic resonance imaging. Both magnetite and hydroxyapatite materials have excellent prospects in nanomedicine with multifunctional therapeutic approaches. To date, many research articles have focused on biomedical applications of nanomaterials because of which it is very difficult to focus on any particular type of nanomaterial. This study is possibly the first effort to emphasize on the comprehensive assessment of MHAp nanostructures for biomedical applications supported with very recent experimental studies. From basic concepts to the real-life applications, the relevant characteristics of magnetic biomaterials are patented which are briefly discussed. The potential therapeutic and diagnostic ability of MHAp-nanostructured materials make them an ideal platform for future nanomedicine. We hope that this advanced review will provide a better understanding of MHAp and its important features to utilize it as a promising material for multifunctional biomedical applications. PMID:29200851

Life sciences today and tomorrow: emerging biotechnologies.

PubMed

Williamson, E Diane

2017-08-01

The purpose of this review is to survey current, emerging and predicted future biotechnologies which are impacting, or are likely to impact in the future on the life sciences, with a projection for the coming 20 years. This review is intended to discuss current and future technical strategies, and to explore areas of potential growth during the foreseeable future. Information technology approaches have been employed to gather and collate data. Twelve broad categories of biotechnology have been identified which are currently impacting the life sciences and will continue to do so. In some cases, technology areas are being pushed forward by the requirement to deal with contemporary questions such as the need to address the emergence of anti-microbial resistance. In other cases, the biotechnology application is made feasible by advances in allied fields in biophysics (e.g. biosensing) and biochemistry (e.g. bio-imaging). In all cases, the biotechnologies are underpinned by the rapidly advancing fields of information systems, electronic communications and the World Wide Web together with developments in computing power and the capacity to handle extensive biological data. A rationale and narrative is given for the identification of each technology as a growth area. These technologies have been categorized by major applications, and are discussed further. This review highlights: Biotechnology has far-reaching applications which impinge on every aspect of human existence. The applications of biotechnology are currently wide ranging and will become even more diverse in the future. Access to supercomputing facilities and the ability to manipulate large, complex biological datasets, will significantly enhance knowledge and biotechnological development.

A systematic approach to the application of Automation, Robotics, and Machine Intelligence Systems /ARAMIS/ to future space projects

NASA Technical Reports Server (NTRS)

Smith, D. B. S.

1982-01-01

The potential applications of Automation, Robotics, and Machine Intelligence Systems (ARAMIS) to space projects are investigated, through a systematic method. In this method selected space projects are broken down into space project tasks, and 69 of these tasks are selected for study. Candidate ARAMIS options are defined for each task. The relative merits of these options are evaluated according to seven indices of performance. Logical sequences of ARAMIS development are also defined. Based on this data, promising applications of ARAMIS are

Energy storage using phase-change materials for active solar heating and cooling: An evaluation of future research and development direction

NASA Astrophysics Data System (ADS)

Borkowski, R. J.; Stovall, T. K.; Kedl, R. J.; Tomlinson, J. J.

1982-04-01

The current state of the art and commercial potential of active solar heating and cooling systems for buildings, and the use of thermal energy storage with these systems are assessed. The need for advanced latent heat storage subsystems in these applications and priorities for their development are determined. Latent storage subsystems are advantageous in applications where their compactness may be exploited. It is suggested that subsystems could facilitate storage in retrofit applications in which storage would be physically impossible otherwise.

Multiobjective optimization in bioinformatics and computational biology.

PubMed

Handl, Julia; Kell, Douglas B; Knowles, Joshua

2007-01-01

This paper reviews the application of multiobjective optimization in the fields of bioinformatics and computational biology. A survey of existing work, organized by application area, forms the main body of the review, following an introduction to the key concepts in multiobjective optimization. An original contribution of the review is the identification of five distinct "contexts," giving rise to multiple objectives: These are used to explain the reasons behind the use of multiobjective optimization in each application area and also to point the way to potential future uses of the technique.

Joint Lead-Free Solder Test Program for High Reliability Military and Space Applications

NASA Technical Reports Server (NTRS)

Brown, Christina

2004-01-01

Current and future space and defense systems face potential risks from the continued use of tin-lead solder, including: compliance with current environmental regulations, concerns about potential environmental legislation banning lead-containing products, reduced mission readiness, and component obsolescence with lead surface finishes. For example, the United States Environmental Protection Agency (USEPA) has lowered the Toxic Chemical Release reporting threshold for lead to 100 pounds. Overseas, the Waste Electrical and Electronic Equipment (WEEE) and the Restriction on Hazardous Substances (RoHS) Dicctives in Europe and similar mandates in Japan have instilled concern that a legislative body will prohibit the use of lead in aerospace/military electronics soldering. Any potential banning of lead compounds could reduce the supplier base and adversely affect the readiness of missions led by the National Aeronautics and Space Administration (NASA) and the U.S. Department of Defense (DoD). Before considering lead-free electronics for system upgrades or future designs, however, it is important for the DoD and NASA to know whether lead-free solders can meet their systems' requirements. No single lead-free solder is likely to qualify for all defense and space applications. Therefore, it is important to validate alternative solders for discrete applications. As a result of the need for comprehensive test data on the reliability of lead-free solders, a partnership was formed between the DoD, NASA, and several original equipment manufactures (OEMs) to conduct solder-joint reliability (laboratory) testing of three lead-free solder alloys on newly manufactured and reworked circuit cards to generate performance data for high-reliability (IPC Class 3) applications.

Mouse brain magnetic resonance microscopy: Applications in Alzheimer disease.

PubMed

Lin, Lan; Fu, Zhenrong; Xu, Xiaoting; Wu, Shuicai

2015-05-01

Over the past two decades, various Alzheimer's disease (AD) trangenetic mice models harboring genes with mutation known to cause familial AD have been created. Today, high-resolution magnetic resonance microscopy (MRM) technology is being widely used in the study of AD mouse models. It has greatly facilitated and advanced our knowledge of AD. In this review, most of the attention is paid to fundamental of MRM, the construction of standard mouse MRM brain template and atlas, the detection of amyloid plaques, following up on brain atrophy and the future applications of MRM in transgenic AD mice. It is believed that future testing of potential drugs in mouse models with MRM will greatly improve the predictability of drug effect in preclinical trials. © 2015 Wiley Periodicals, Inc.

A theoretical flaw in the advance market commitment idea.

PubMed

Sonderholm, Jorn

2010-06-01

Infectious and parasitic diseases cause massive health problems in the developing world. Research and development of drugs for diseases that mainly affect poor people in developing countries is limited. The advance market commitment (AMC) idea is an incentivising mechanism for research and development of drugs for neglected diseases. Discussion of the AMC idea is of renewed interest given the launch in June 2009 of the first AMC. This pilot AMC is designed to, among other things, test the idea for potential future applications. This paper is a critique of the AMC idea. It seeks to show that the idea has a hitherto unrecognised theoretical flaw that should make policy-makers and donors hesitant to embrace future applications of the idea.

Recent Advances of MEMS Resonators for Lorentz Force Based Magnetic Field Sensors: Design, Applications and Challenges.

PubMed

Herrera-May, Agustín Leobardo; Soler-Balcazar, Juan Carlos; Vázquez-Leal, Héctor; Martínez-Castillo, Jaime; Vigueras-Zuñiga, Marco Osvaldo; Aguilera-Cortés, Luz Antonio

2016-08-24

Microelectromechanical systems (MEMS) resonators have allowed the development of magnetic field sensors with potential applications such as biomedicine, automotive industry, navigation systems, space satellites, telecommunications and non-destructive testing. We present a review of recent magnetic field sensors based on MEMS resonators, which operate with Lorentz force. These sensors have a compact structure, wide measurement range, low energy consumption, high sensitivity and suitable performance. The design methodology, simulation tools, damping sources, sensing techniques and future applications of magnetic field sensors are discussed. The design process is fundamental in achieving correct selection of the operation principle, sensing technique, materials, fabrication process and readout systems of the sensors. In addition, the description of the main sensing systems and challenges of the MEMS sensors are discussed. To develop the best devices, researches of their mechanical reliability, vacuum packaging, design optimization and temperature compensation circuits are needed. Future applications will require multifunctional sensors for monitoring several physical parameters (e.g., magnetic field, acceleration, angular ratio, humidity, temperature and gases).

Recent Advances of MEMS Resonators for Lorentz Force Based Magnetic Field Sensors: Design, Applications and Challenges

PubMed Central

Herrera-May, Agustín Leobardo; Soler-Balcazar, Juan Carlos; Vázquez-Leal, Héctor; Martínez-Castillo, Jaime; Vigueras-Zuñiga, Marco Osvaldo; Aguilera-Cortés, Luz Antonio

2016-01-01

Microelectromechanical systems (MEMS) resonators have allowed the development of magnetic field sensors with potential applications such as biomedicine, automotive industry, navigation systems, space satellites, telecommunications and non-destructive testing. We present a review of recent magnetic field sensors based on MEMS resonators, which operate with Lorentz force. These sensors have a compact structure, wide measurement range, low energy consumption, high sensitivity and suitable performance. The design methodology, simulation tools, damping sources, sensing techniques and future applications of magnetic field sensors are discussed. The design process is fundamental in achieving correct selection of the operation principle, sensing technique, materials, fabrication process and readout systems of the sensors. In addition, the description of the main sensing systems and challenges of the MEMS sensors are discussed. To develop the best devices, researches of their mechanical reliability, vacuum packaging, design optimization and temperature compensation circuits are needed. Future applications will require multifunctional sensors for monitoring several physical parameters (e.g., magnetic field, acceleration, angular ratio, humidity, temperature and gases). PMID:27563912

Mapping of multiple parameter m-health scenarios to mobile WiMAX QoS variables.

PubMed

Alinejad, Ali; Philip, N; Istepanian, R S H

2011-01-01

Multiparameter m-health scenarios with bandwidth demanding requirements will be one of key applications in future 4 G mobile communication systems. These applications will potentially require specific spectrum allocations with higher quality of service requirements. Furthermore, one of the key 4 G technologies targeting m-health will be medical applications based on WiMAX systems. Hence, it is timely to evaluate such multiple parametric m-health scenarios over mobile WiMAX networks. In this paper, we address the preliminary performance analysis of mobile WiMAX network for multiparametric telemedical scenarios. In particular, we map the medical QoS to typical WiMAX QoS parameters to optimise the performance of these parameters in typical m-health scenario. Preliminary performance analyses of the proposed multiparametric scenarios are evaluated to provide essential information for future medical QoS requirements and constraints in these telemedical network environments.

Surface engineering of graphene-based nanomaterials for biomedical applications.

PubMed

Shi, Sixiang; Chen, Feng; Ehlerding, Emily B; Cai, Weibo

2014-09-17

Graphene-based nanomaterials have attracted tremendous interest over the past decade due to their unique electronic, optical, mechanical, and chemical properties. However, the biomedical applications of these intriguing nanomaterials are still limited due to their suboptimal solubility/biocompatibility, potential toxicity, and difficulties in achieving active tumor targeting, just to name a few. In this Topical Review, we will discuss in detail the important role of surface engineering (i.e., bioconjugation) in improving the in vitro/in vivo stability and enriching the functionality of graphene-based nanomaterials, which can enable single/multimodality imaging (e.g., optical imaging, positron emission tomography, magnetic resonance imaging) and therapy (e.g., photothermal therapy, photodynamic therapy, and drug/gene delivery) of cancer. Current challenges and future research directions are also discussed and we believe that graphene-based nanomaterials are attractive nanoplatforms for a broad array of future biomedical applications.

Anaerobic biorefinery: Current status, challenges, and opportunities.

PubMed

Sawatdeenarunat, Chayanon; Nguyen, Duc; Surendra, K C; Shrestha, Shilva; Rajendran, Karthik; Oechsner, Hans; Xie, Li; Khanal, Samir Kumar

2016-09-01

Anaerobic digestion (AD) has been in use for many decades. To date, it has been primarily aimed at treating organic wastes, mainly manures and wastewater sludge, and industrial wastewaters. However, with the current advancements, a more open mind is required to look beyond these somewhat restricted original applications of AD. Biorefineries are such concepts, where multiple products including chemicals, fuels, polymers etc. are produced from organic feedstocks. The anaerobic biorefinery concept is now gaining increased attention, utilizing AD as the final disposal step. This review aims at evaluating the potential significance of anaerobic biorefineries, including types of feedstocks, uses for the produced energy, as well as sustainable applications of the generated residual digestate. A comprehensive analysis of various types of anaerobic biorefineries has been developed, including both large-scale and household level applications. Finally, future directives are highlighted showing how anaerobic biorefinery concept could impact the bioeconomy in the near future. Copyright © 2016 Elsevier Ltd. All rights reserved.

Enabling functional genomics with genome engineering.

PubMed

Hilton, Isaac B; Gersbach, Charles A

2015-10-01

Advances in genome engineering technologies have made the precise control over genome sequence and regulation possible across a variety of disciplines. These tools can expand our understanding of fundamental biological processes and create new opportunities for therapeutic designs. The rapid evolution of these methods has also catalyzed a new era of genomics that includes multiple approaches to functionally characterize and manipulate the regulation of genomic information. Here, we review the recent advances of the most widely adopted genome engineering platforms and their application to functional genomics. This includes engineered zinc finger proteins, TALEs/TALENs, and the CRISPR/Cas9 system as nucleases for genome editing, transcription factors for epigenome editing, and other emerging applications. We also present current and potential future applications of these tools, as well as their current limitations and areas for future advances. © 2015 Hilton and Gersbach; Published by Cold Spring Harbor Laboratory Press.

Surface Engineering of Graphene-Based Nanomaterials for Biomedical Applications

PubMed Central

2015-01-01

Graphene-based nanomaterials have attracted tremendous interest over the past decade due to their unique electronic, optical, mechanical, and chemical properties. However, the biomedical applications of these intriguing nanomaterials are still limited due to their suboptimal solubility/biocompatibility, potential toxicity, and difficulties in achieving active tumor targeting, just to name a few. In this Topical Review, we will discuss in detail the important role of surface engineering (i.e., bioconjugation) in improving the in vitro/in vivo stability and enriching the functionality of graphene-based nanomaterials, which can enable single/multimodality imaging (e.g., optical imaging, positron emission tomography, magnetic resonance imaging) and therapy (e.g., photothermal therapy, photodynamic therapy, and drug/gene delivery) of cancer. Current challenges and future research directions are also discussed and we believe that graphene-based nanomaterials are attractive nanoplatforms for a broad array of future biomedical applications. PMID:25117569

Laser-induced breakdown spectroscopy (LIBS): an overview of recent progress and future potential for biomedical applications.

PubMed

Rehse, S J; Salimnia, H; Miziolek, A W

2012-02-01

The recent progress made in developing laser-induced breakdown spectroscopy (LIBS) has transformed LIBS from an elemental analysis technique to one that can be applied for the reagentless analysis of molecularly complex biological materials or clinical specimens. Rapid advances in the LIBS technology have spawned a growing number of recently published articles in peer-reviewed journals which have consistently demonstrated the capability of LIBS to rapidly detect, biochemically characterize and analyse, and/or accurately identify various biological, biomedical or clinical samples. These analyses are inherently real-time, require no sample preparation, and offer high sensitivity and specificity. This overview of the biomedical applications of LIBS is meant to summarize the research that has been performed to date, as well as to suggest to health care providers several possible specific future applications which, if successfully implemented, would be significantly beneficial to humankind.

Global land cover mapping and characterization: present situation and future research priorities

USGS Publications Warehouse

Giri, Chandra

2005-01-01

The availability and accessibility of global land cover data sets plays an important role in many global change studies. The importance of such science‐based information is also reflected in a number of international, regional, and national projects and programs. Recent developments in earth observing satellite technology, information technology, computer hardware and software, and infrastructure development have helped developed better quality land cover data sets. As a result, such data sets are increasingly becoming available, the user‐base is ever widening, application areas have been expanding, and the potential of many other applications are enormous. Yet, we are far from producing high quality global land cover data sets. This paper examines the progress in the development of digital global land cover data, their availability, and current applications. Problems and opportunities are also explained. The overview sets the stage for identifying future research priorities needed for operational land cover assessment and monitoring.

Terahertz (THz) Wireless Systems for Space Applications

NASA Technical Reports Server (NTRS)

Hwu, Shian U.; deSilva, Kanishka B.; Jih, Cindy T.

2013-01-01

NASA has been leading the Terahertz (THz) technology development for the sensors and instruments in astronomy in the past 20 years. THz technologies are expanding into much broader applications in recent years. Due to the vast available multiple gigahertz (GHz) broad bandwidths, THz radios offer the possibility for wireless transmission of high data rates. Multi-Gigabits per second (MGbps) broadband wireless access based on THz waves are closer to reality. The THz signal high atmosphere attenuation could significantly decrease the communication ranges and transmittable data rates for the ground systems. Contrary to the THz applications on the ground, the space applications in the atmosphere free environment do not suffer the atmosphere attenuation. The manufacturing technologies for the THz electronic components are advancing and maturing. There is great potential for the NASA future high data wireless applications in environments with difficult cabling and size/weight constraints. In this study, the THz wireless systems for potential space applications were investigated. The applicability of THz systems for space applications was analyzed. The link analysis indicates that MGbps data rates are achievable with compact sized high gain antennas.

Evaluation of the Intel iWarp parallel processor for space flight applications

NASA Technical Reports Server (NTRS)

Hine, Butler P., III; Fong, Terrence W.

1993-01-01

The potential of a DARPA-sponsored advanced processor, the Intel iWarp, for use in future SSF Data Management Systems (DMS) upgrades is evaluated through integration into the Ames DMS testbed and applications testing. The iWarp is a distributed, parallel computing system well suited for high performance computing applications such as matrix operations and image processing. The system architecture is modular, supports systolic and message-based computation, and is capable of providing massive computational power in a low-cost, low-power package. As a consequence, the iWarp offers significant potential for advanced space-based computing. This research seeks to determine the iWarp's suitability as a processing device for space missions. In particular, the project focuses on evaluating the ease of integrating the iWarp into the SSF DMS baseline architecture and the iWarp's ability to support computationally stressing applications representative of SSF tasks.

Recent progress on gas sensor based on quantum cascade lasers and hollow fiber waveguides

NASA Astrophysics Data System (ADS)

Liu, Ningwu; Sun, Juan; Deng, Hao; Ding, Junya; Zhang, Lei; Li, Jingsong

2017-02-01

Mid-infrared laser spectroscopy provides an ideal platform for trace gas sensing applications. Despite this potential, early MIR sensing applications were limited due to the size of the involved optical components, e.g. light sources and sample cells. A potential solution to this demand is the integration of hollow fiber waveguide with novelty quantum cascade lasers.Recently QCLs had great improvements in power, efficiency and wavelength range, which made the miniaturized platforms for gas sensing maintaining or even enhancing the achievable sensitivity conceivable. So that the miniaturization of QCLs and HWGs can be evolved into a mini sensor, which may be tailored to a variety of real-time and in situ applications ranging from environmental monitoring to workplace safety surveillance. In this article, we introduce QCLs and HWGs, display the applications of HWG based on QCL gas sensing and discuss future strategies for hollow fiber coupled quantum cascade laser gas sensor technology.

Voice Technologies in Libraries: A Look into the Future.

ERIC Educational Resources Information Center

Lange, Holley R., Ed.; And Others

1991-01-01

Discussion of synthesized speech and voice recognition focuses on a forum that addressed the potential for speech technologies in libraries. Topics discussed by three contributors include possible library applications in technical processing, book receipt, circulation control, and database access; use by disabled and illiterate users; and problems…

An App for Every Psychological Problem: Vision for the Future

ERIC Educational Resources Information Center

Brown, Alicia M.

2016-01-01

Innovations in mobile technology are occurring at a rapid pace. Mobile phone software applications (apps) in particular have great potential within the field of mental health. Lack of organizational oversight and hesitancy from providers to utilize mobile technology has delayed technological advancement--consequently limiting the ability of the…

["Big data" - large data, a lot of knowledge?].

PubMed

Hothorn, Torsten

2015-01-28

Since a couple of years, the term Big Data describes technologies to extract knowledge from data. Applications of Big Data and their consequences are also increasingly discussed in the mass media. Because medicine is an empirical science, we discuss the meaning of Big Data and its potential for future medical research.

Optical Information Processing for Aerospace Applications 2

NASA Technical Reports Server (NTRS)

Stermer, R. L. (Compiler)

1984-01-01

Current research in optical processing, and determination of its role in future aerospace systems was reviewed. It is shown that optical processing offers significant potential for aircraft and spacecraft control, pattern recognition, and robotics. It is demonstrated that the development of optical devices and components can be implemented in practical aerospace configurations.

Energy and solid/hazardous waste

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

1981-12-01

This report addresses the past and potential future solid and hazardous waste impacts from energy development, and summarizes the major environmental, legislation applicable to solid and hazardous waste generation and disposal. A glossary of terms and acronyms used to describe and measure solid waste impacts of energy development is included. (PSB)

Black Men in the Medical Education Pipeline: Past, Present, and Future.

ERIC Educational Resources Information Center

Ready, Timothy; Nickens, Herbert W.

1991-01-01

Factors in the decline in Black male enrollment in medical schools are examined, including the general medical school applicant pool, popularity of undergraduate biology degrees, Black enrollment in college, poverty, and employment opportunities. Social implications, areas for further research, and potential solutions are discussed. (Author/MSE)

Application of landscape models to alternative futures analyses

Treesearch

Anne C. Neale; K. Bruce Jones; Maliha S. Nash; Rick D. Van Remortel; James D. Wickham; Kurt H. Riitters; Robert V. O' neil

2003-01-01

Scientists and environmental managers alike are concerned about broadscale changes in land use and landscape pattern and their cumulative impact on environmental and economic end points, such as water quality and quantity, species habitat, productivity, erosion potential, recreational value, and overall ecological health (Rapport et al., 1998). They also are interested...

Lavandula angustifolia Miller: English lavender.

PubMed

Denner, Sallie Stoltz

2009-01-01

Folk and traditional therapeutic use of the essential oil of English lavender for pain, infection, relaxation, and sedation dates back centuries. Current research focusing on the inherent synergism of Lavandula angustifolia Miller demonstrates great potential for future applications. Today's investigations may provide the key to eradicating degenerative inflammatory disease, infectious disease, and carcinogenesis.

13 CFR 124.402 - How does a Participant develop a business plan?

Code of Federal Regulations, 2010 CFR

2010-01-01

... Participant must develop a comprehensive business plan setting forth its business targets, objectives, and... future plans to enter into one or more new markets; (2) The applicant's designation of its primary industry classification, as defined in § 124.3; (3) An analysis of market potential, competitive...

Toward the Development of Expert Assessment Systems.

ERIC Educational Resources Information Center

Hasselbring, Ted S.

1986-01-01

The potential application of "expert systems" to the diagnosis and assessment of special-needs children is examined and existing prototype systems are reviewed. The future of this artificial intelligence technology is discussed in relation to emerging development tools designed for the creation of expert systems by the lay public. (Author)

Military clouds: utilization of cloud computing systems at the battlefield

NASA Astrophysics Data System (ADS)

Süleyman, Sarıkürk; Volkan, Karaca; İbrahim, Kocaman; Ahmet, Şirzai

2012-05-01

Cloud computing is known as a novel information technology (IT) concept, which involves facilitated and rapid access to networks, servers, data saving media, applications and services via Internet with minimum hardware requirements. Use of information systems and technologies at the battlefield is not new. Information superiority is a force multiplier and is crucial to mission success. Recent advances in information systems and technologies provide new means to decision makers and users in order to gain information superiority. These developments in information technologies lead to a new term, which is known as network centric capability. Similar to network centric capable systems, cloud computing systems are operational today. In the near future extensive use of military clouds at the battlefield is predicted. Integrating cloud computing logic to network centric applications will increase the flexibility, cost-effectiveness, efficiency and accessibility of network-centric capabilities. In this paper, cloud computing and network centric capability concepts are defined. Some commercial cloud computing products and applications are mentioned. Network centric capable applications are covered. Cloud computing supported battlefield applications are analyzed. The effects of cloud computing systems on network centric capability and on the information domain in future warfare are discussed. Battlefield opportunities and novelties which might be introduced to network centric capability by cloud computing systems are researched. The role of military clouds in future warfare is proposed in this paper. It was concluded that military clouds will be indispensible components of the future battlefield. Military clouds have the potential of improving network centric capabilities, increasing situational awareness at the battlefield and facilitating the settlement of information superiority.

A multi-level strategy for anticipating future glacier lake formation and associated hazard potentials

NASA Astrophysics Data System (ADS)

Frey, H.; Haeberli, W.; Linsbauer, A.; Huggel, C.; Paul, F.

2010-02-01

In the course of glacier retreat, new glacier lakes can develop. As such lakes can be a source of natural hazards, strategies for predicting future glacier lake formation are important for an early planning of safety measures. In this article, a multi-level strategy for the identification of overdeepened parts of the glacier beds and, hence, sites with potential future lake formation, is presented. At the first two of the four levels of this strategy, glacier bed overdeepenings are estimated qualitatively and over large regions based on a digital elevation model (DEM) and digital glacier outlines. On level 3, more detailed and laborious models are applied for modeling the glacier bed topography over smaller regions; and on level 4, special situations must be investigated in-situ with detailed measurements such as geophysical soundings. The approaches of the strategy are validated using historical data from Trift Glacier, where a lake formed over the past decade. Scenarios of future glacier lakes are shown for the two test regions Aletsch and Bernina in the Swiss Alps. In the Bernina region, potential future lake outbursts are modeled, using a GIS-based hydrological flow routing model. As shown by a corresponding test, the ASTER GDEM and the SRTM DEM are both suitable to be used within the proposed strategy. Application of this strategy in other mountain regions of the world is therefore possible as well.

Critical overview of applications of genetic testing in sport talent identification.

PubMed

Roth, Stephen M

2012-12-01

Talent identification for future sport performance is of paramount interest for many groups given the challenges of finding and costs of training potential elite athletes. Because genetic factors have been implicated in many performance- related traits (strength, endurance, etc.), a natural inclination is to consider the addition of genetic testing to talent identification programs. While the importance of genetic factors to sport performance is generally not disputed, whether genetic testing can positively inform talent identification is less certain. The present paper addresses the science behind the genetic tests that are now commercially available (some under patent protection) and aimed at predicting future sport performance potential. Also discussed are the challenging ethical issues that emerge from the availability of these tests. The potential negative consequences associated with genetic testing of young athletes will very likely outweigh any positive benefit for sport performance prediction at least for the next several years. The paper ends by exploring the future possibilities for genetic testing as the science of genomics in sport matures over the coming decade(s).

Intelligent Agents and Their Potential for Future Design and Synthesis Environment

NASA Technical Reports Server (NTRS)

Noor, Ahmed K. (Compiler); Malone, John B. (Compiler)

1999-01-01

This document contains the proceedings of the Workshop on Intelligent Agents and Their Potential for Future Design and Synthesis Environment, held at NASA Langley Research Center, Hampton, VA, September 16-17, 1998. The workshop was jointly sponsored by the University of Virginia's Center for Advanced Computational Technology and NASA. Workshop attendees came from NASA, industry and universities. The objectives of the workshop were to assess the status of intelligent agents technology and to identify the potential of software agents for use in future design and synthesis environment. The presentations covered the current status of agent technology and several applications of intelligent software agents. Certain materials and products are identified in this publication in order to specify adequately the materials and products that were investigated in the research effort. In no case does such identification imply recommendation or endorsement of products by NASA, nor does it imply that the materials and products are the only ones or the best ones available for this purpose. In many cases equivalent materials and products are available and would probably produce equivalent results.

Small Engine Component Technology (SECT) study. Program report

NASA Technical Reports Server (NTRS)

Almodovar, E.; Exley, T.; Kaehler, H.; Schneider, W.

1986-01-01

The study was conducted to identify high payoff technologies for year 2000 small gas turbine applications and to provide a technology plan for guiding future research and technology efforts. A regenerative cycle turboprop engine was selected for a 19 passenger commuter aircraft application. A series of engines incorporating eight levels of advanced technologies were studied and their impact on aircraft performance was evaluated. The study indicated a potential reduction in fuel burn of 38.3 percent. At $1.00 per gallon fuel price, a potential DOC benefit of 12.5 percent would be achieved. At $2.00 per gallon, the potential DOC benefit would increase to 17.0 percent. Four advanced technologies are recommended and appropriate research and technology programs were established to reach the year 2000 goals.

Silk fibroin as biomaterial for bone tissue engineering.

PubMed

Melke, Johanna; Midha, Swati; Ghosh, Sourabh; Ito, Keita; Hofmann, Sandra

2016-02-01

Silk fibroin (SF) is a fibrous protein which is produced mainly by silkworms and spiders. Its unique mechanical properties, tunable biodegradation rate and the ability to support the differentiation of mesenchymal stem cells along the osteogenic lineage, have made SF a favorable scaffold material for bone tissue engineering. SF can be processed into various scaffold forms, combined synergistically with other biomaterials to form composites and chemically modified, which provides an impressive toolbox and allows SF scaffolds to be tailored to specific applications. This review discusses and summarizes recent advancements in processing SF, focusing on different fabrication and functionalization methods and their application to grow bone tissue in vitro and in vivo. Potential areas for future research, current challenges, uncertainties and gaps in knowledge are highlighted. Silk fibroin is a natural biomaterial with remarkable biomedical and mechanical properties which make it favorable for a broad range of bone tissue engineering applications. It can be processed into different scaffold forms, combined synergistically with other biomaterials to form composites and chemically modified which provides a unique toolbox and allows silk fibroin scaffolds to be tailored to specific applications. This review discusses and summarizes recent advancements in processing silk fibroin, focusing on different fabrication and functionalization methods and their application to grow bone tissue in vitro and in vivo. Potential areas for future research, current challenges, uncertainties and gaps in knowledge are highlighted. Copyright © 2015 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.

CRISPR-mediated Ophthalmic Genome Surgery.

PubMed

Cho, Galaxy Y; Abdulla, Yazeed; Sengillo, Jesse D; Justus, Sally; Schaefer, Kellie A; Bassuk, Alexander G; Tsang, Stephen H; Mahajan, Vinit B

2017-09-01

Clustered regularly interspaced short palindromic repeats (CRISPR) is a genome engineering system with great potential for clinical applications due to its versatility and programmability. This review highlights the development and use of CRISPR-mediated ophthalmic genome surgery in recent years. Diverse CRISPR techniques are in development to target a wide array of ophthalmic conditions, including inherited and acquired conditions. Preclinical disease modeling and recent successes in gene editing suggest potential efficacy of CRISPR as a therapeutic for inherited conditions. In particular, the treatment of Leber congenital amaurosis with CRISPR-mediated genome surgery is expected to reach clinical trials in the near future. Treatment options for inherited retinal dystrophies are currently limited. CRISPR-mediated genome surgery methods may be able to address this unmet need in the future.

Road to the future of systems biotechnology: CRISPR-Cas-mediated metabolic engineering for recombinant protein production.

PubMed

Roointan, Amir; Morowvat, Mohammad Hossein

The rising potential for CRISPR-Cas-mediated genome editing has revolutionized our strategies in basic and practical bioengineering research. It provides a predictable and precise method for genome modification in a robust and reproducible fashion. Emergence of systems biotechnology and synthetic biology approaches coupled with CRISPR-Cas technology could change the future of cell factories to possess some new features which have not been found naturally. We have discussed the possibility and versatile potentials of CRISPR-Cas technology for metabolic engineering of a recombinant host for heterologous protein production. We describe the mechanisms involved in this metabolic engineering approach and present the diverse features of its application in biotechnology and protein production.

The Environmental Protection Agency's Safety Standards for Disposal of Spent Nuclear Fuel: Potential Path Forward in Response to the Report of the Blue Ribbon Commission on America's Nuclear Future - 13388

DOE Office of Scientific and Technical Information (OSTI.GOV)

Forinash, Betsy; Schultheisz, Daniel; Peake, Tom

2013-07-01

Following the decision to withdraw the Yucca Mountain license application, the Department of Energy created a Blue Ribbon Commission (BRC) on America's Nuclear Future, tasked with recommending a national strategy to manage the back end of the nuclear fuel cycle. The BRC issued its final report in January 2012, with recommendations covering transportation, storage and disposal of spent nuclear fuel (SNF); potential reprocessing; and supporting institutional measures. The BRC recommendations on disposal of SNF and high-level waste (HLW) are relevant to the U.S. Environmental Protection Agency (EPA), which shares regulatory responsibility with the Nuclear Regulatory Commission (NRC): EPA issues 'generallymore » applicable' performance standards for disposal repositories, which are then implemented in licensing. For disposal, the BRC endorses developing one or more geological repositories, with siting based on an approach that is adaptive, staged and consent-based. The BRC recommends that EPA and NRC work cooperatively to issue generic disposal standards-applying equally to all sites-early in any siting process. EPA previously issued generic disposal standards that apply to all sites other than Yucca Mountain. However, the BRC concluded that the existing regulations should be revisited and revised. The BRC proposes a number of general principles to guide the development of future regulations. EPA continues to review the BRC report and to assess the implications for Agency action, including potential regulatory issues and considerations if EPA develops new or revised generic disposal standards. This review also involves preparatory activities to define potential process and public engagement approaches. (authors)« less

Immobilization Technologies in Probiotic Food Production

PubMed Central

Mitropoulou, Gregoria; Nedovic, Viktor; Goyal, Arun; Kourkoutas, Yiannis

2013-01-01

Various supports and immobilization/encapsulation techniques have been proposed and tested for application in functional food production. In the present review, the use of probiotic microorganisms for the production of novel foods is discussed, while the benefits and criteria of using probiotic cultures are analyzed. Subsequently, immobilization/encapsulation applications in the food industry aiming at the prolongation of cell viability are described together with an evaluation of their potential future impact, which is also highlighted and assessed. PMID:24288597

Chemical Vapor Sensing with Monolayer MoS2

DTIC Science & Technology

2013-01-04

show great potential for future nanoscale electronic devices. The high surface-to-volume ratio is a natural asset for applications such as chemical...For the devices in this study, 3 bulk sources of MoS2 were used. One piece was obtained from a colleague’s tribology research project (called the...devices were ~20 cm2/Vs. Although the conductance of our monolayer MoS2 devices can be increased significantly by application of a back gate

Applications of the Analytical Electron Microscope to Materials Science

NASA Technical Reports Server (NTRS)

Goldstein, J. I.

1992-01-01

In the last 20 years, the analytical electron microscope (AEM) as allowed investigators to obtain chemical and structural information from less than 50 nanometer diameter regions in thin samples of materials and to explore problems where reactions occur at boundaries and interfaces or within small particles or phases in bulk samples. Examples of the application of the AEM to materials science problems are presented in this paper and demonstrate the usefulness and the future potential of this instrument.

MSFC Skylab program engineering and integration

NASA Technical Reports Server (NTRS)

1974-01-01

A technical history and managerial critique of the MSFC role in the Skylab program is presented. The George C. Marshall Space Flight Center had primary hardware development responsibility for the Saturn Workshop Modules and many of the designated experiments in addition to the system integration responsibility for the entire Skylab Orbital Cluster. The report also includes recommendations and conclusions applicable to hardware design, test program philosophy and performance, and program management techniques with potential application to future programs.

Radiation Exposure Effects and Shielding Analysis of Carbon Nanotube Materials

NASA Technical Reports Server (NTRS)

Wilkins, Richard; Armendariz, Lupita (Technical Monitor)

2002-01-01

Carbon nanotube materials promise to be the basis for a variety of emerging technologies with aerospace applications. Potential applications to human space flight include spacecraft shielding, hydrogen storage, structures and fixtures and nano-electronics. Appropriate risk analysis on the properties of nanotube materials is essential for future mission safety. Along with other environmental hazards, materials used in space flight encounter a hostile radiation environment for all mission profiles, from low earth orbit to interplanetary space.

A Historical Review of Brayton and Stirling Power Conversion Technologies for Space Applications

NASA Technical Reports Server (NTRS)

Mason, Lee S.; Schreiber, Jeffrey G.

2007-01-01

Dynamic power conversion technologies, such as closed Brayton and free-piston Stirling, offer many advantages for space power applications including high efficiency, long life, and attractive scaling characteristics. This paper presents a historical review of Brayton and Stirling power conversion technology for space and discusses on-going development activities in order to illustrate current technology readiness. The paper also presents a forecast of potential future space uses of these power technologies.

Addictive Potential of Internet Applications and Differential Correlates of Problematic Use in Internet Gamers versus Generalized Internet Users in a Representative Sample of Adolescents.

PubMed

Rosenkranz, Tabea; Müller, Kai W; Dreier, Michael; Beutel, Manfred E; Wölfling, Klaus

2017-01-01

This paper examines the addictive potential of 8 different Internet applications, distinguishing male and female users. Moreover, differential correlates of problematic use are investigated in Internet gamers (IG) and generalized Internet users (GIU). In a representative sample of 5,667 adolescents aged 12-19 years, use of Internet applications, problematic Internet use, psychopathologic symptoms (emotional problems, hyperactivity/inattention, and psychosomatic complaints), personality (conscientiousness and extraversion), psychosocial correlates (perceived stress and self-efficacy), and coping strategies were assessed. The addictive potential of Internet applications was examined in boys and girls using regression analysis. MANOVAs were conducted to examine differential correlates of problematic Internet use between IG and GIU. Chatting and social networking most strongly predicted problematic Internet use in girls, while gaming was the strongest predictor in boys. Problematic IG exhibited multiple psychosocial problems compared to non-problematic IG. In problematic Internet users, GIU reported even higher psychosocial burden and displayed dysfunctional coping strategies more frequently than gamers. The results extend previous findings on the addictive potential of Internet applications and validate the proposed distinction between specific and generalized problematic Internet use. In addition to Internet gaming disorder, future studies should also focus on other highly addictive Internet applications, that is, chatting or social networking, regarding differential correlates of problematic use. © 2017 S. Karger AG, Basel.

Evaluating rare earth element availability: a case with revolutionary demand from clean technologies.

PubMed

Alonso, Elisa; Sherman, Andrew M; Wallington, Timothy J; Everson, Mark P; Field, Frank R; Roth, Richard; Kirchain, Randolph E

2012-03-20

The future availability of rare earth elements (REEs) is of concern due to monopolistic supply conditions, environmentally unsustainable mining practices, and rapid demand growth. We present an evaluation of potential future demand scenarios for REEs with a focus on the issue of comining. Many assumptions were made to simplify the analysis, but the scenarios identify some key variables that could affect future rare earth markets and market behavior. Increased use of wind energy and electric vehicles are key elements of a more sustainable future. However, since present technologies for electric vehicles and wind turbines rely heavily on dysprosium (Dy) and neodymium (Nd), in rare-earth magnets, future adoption of these technologies may result in large and disproportionate increases in the demand for these two elements. For this study, upper and lower bound usage projections for REE in these applications were developed to evaluate the state of future REE supply availability. In the absence of efficient reuse and recycling or the development of technologies which use lower amounts of Dy and Nd, following a path consistent with stabilization of atmospheric CO(2) at 450 ppm may lead to an increase of more than 700% and 2600% for Nd and Dy, respectively, over the next 25 years if the present REE needs in automotive and wind applications are representative of future needs.

Technology Applications that Support Space Exploration

NASA Technical Reports Server (NTRS)

Henderson, Edward M.; Holderman, Mark L.

2011-01-01

Several enabling technologies have been identified that would provide significant benefits for future space exploration. In-Space demonstrations should be chosen so that these technologies will have a timely opportunity to improve efficiencies and reduce risks for future spaceflight. An early window exists to conduct ground and flight demonstrations that make use of existing assets that were developed for the Space Shuttle and the Constellation programs. The work could be mostly performed using residual program civil servants, existing facilities and current commercial launch capabilities. Partnering these abilities with the emerging commercial sector, along with other government agencies, academia and with international partners would provide an affordable and timely approach to get the launch costs down for these payloads, while increasing the derived benefits to a larger community. There is a wide scope of varied technologies that are being considered to help future space exploration. However, the cost and schedule would be prohibitive to demonstrate all these in the near term. Determining which technologies would yield the best return in meeting our future space needs is critical to building an achievable Space Architecture that allows exploration beyond Low Earth Orbit. The best mix of technologies is clearly to be based on our future needs, but also must take into account the availability of existing assets and supporting partners. Selecting those technologies that have complimentary applications will provide the most knowledge, with reasonable cost, for future use The plan is to develop those applications that not only mature the technology but actually perform a useful task or mission. These might include such functions as satellite servicing, a propulsion stage, processing lunar regolith, generating and transmitting solar power, cryogenic fluid transfer and storage and artificial gravity. Applications have been selected for assessment for future consideration and are addressed in this paper. These applications have been made available to the various NASA study groups that are determining the next steps the Agency must take to secure a sound foundation for future space exploration The paper also addresses how follow-on demonstrations, as launch performance grows, can build on the earlier applications to provide increased benefits for both the commercial and scientific communities. The architecture of incrementally building upon previous successes and insights dramatically lowers the overall associated risk for developing and maturing the key enabling technologies. The goal is to establish a potential business case that encourages commercial activity, thereby reducing the cost for the demonstration while using the technology maturation in developing readiness for future space exploration with overall less risk.

Porphyrin-Based Nanostructures for Photocatalytic Applications

PubMed Central

Chen, Yingzhi; Li, Aoxiang; Huang, Zheng-Hong; Wang, Lu-Ning; Kang, Feiyu

2016-01-01

Well-defined organic nanostructures with controllable size and morphology are increasingly exploited in optoelectronic devices. As promising building blocks, porphyrins have demonstrated great potentials in visible-light photocatalytic applications, because of their electrical, optical and catalytic properties. From this perspective, we have summarized the recent significant advances on the design and photocatalytic applications of porphyrin-based nanostructures. The rational strategies, such as texture or crystal modification and interfacial heterostructuring, are described. The applications of the porphyrin-based nanostructures in photocatalytic pollutant degradation and hydrogen evolution are presented. Finally, the ongoing challenges and opportunities for the future development of porphyrin nanostructures in high-quality nanodevices are also proposed. PMID:28344308

Applications of Three-Dimensional Printing in Surgery.

PubMed

Li, Chi; Cheung, Tsz Fung; Fan, Vei Chen; Sin, Kin Man; Wong, Chrisity Wai Yan; Leung, Gilberto Ka Kit

2017-02-01

Three-dimensional (3D) printing is a rapidly advancing technology in the field of surgery. This article reviews its contemporary applications in 3 aspects of surgery, namely, surgical planning, implants and prostheses, and education and training. Three-dimensional printing technology can contribute to surgical planning by depicting precise personalized anatomy and thus a potential improvement in surgical outcome. For implants and prosthesis, the technology might overcome the limitations of conventional methods such as visual discrepancy from the recipient's body and unmatching anatomy. In addition, 3D printing technology could be integrated into medical school curriculum, supplementing the conventional cadaver-based education and training in anatomy and surgery. Future potential applications of 3D printing in surgery, mainly in the areas of skin, nerve, and vascular graft preparation as well as ear reconstruction, are also discussed. Numerous trials and studies are still ongoing. However, scientists and clinicians are still encountering some limitations of the technology including high cost, long processing time, unsatisfactory mechanical properties, and suboptimal accuracy. These limitations might potentially hamper the applications of this technology in daily clinical practice.

Exploring a model-driven architecture (MDA) approach to health care information systems development.

PubMed

Raghupathi, Wullianallur; Umar, Amjad

2008-05-01

To explore the potential of the model-driven architecture (MDA) in health care information systems development. An MDA is conceptualized and developed for a health clinic system to track patient information. A prototype of the MDA is implemented using an advanced MDA tool. The UML provides the underlying modeling support in the form of the class diagram. The PIM to PSM transformation rules are applied to generate the prototype application from the model. The result of the research is a complete MDA methodology to developing health care information systems. Additional insights gained include development of transformation rules and documentation of the challenges in the application of MDA to health care. Design guidelines for future MDA applications are described. The model has the potential for generalizability. The overall approach supports limited interoperability and portability. The research demonstrates the applicability of the MDA approach to health care information systems development. When properly implemented, it has the potential to overcome the challenges of platform (vendor) dependency, lack of open standards, interoperability, portability, scalability, and the high cost of implementation.

Recent advances in non-ionic surfactant vesicles (niosomes): self-assembly, fabrication, characterization, drug delivery applications and limitations.

PubMed

Abdelkader, Hamdy; Alani, Adam W G; Alany, Raid G

2014-03-01

Non-ionic surfactant vesicles, simply known as niosomes are synthetic vesicles with potential technological applications. Niosomes have the same potential advantages of phospholipid vesicles (liposomes) of being able to accommodate both water soluble and lipid soluble drug molecules control their release and as such serve as versatile drug delivery devices of numerous applications. Additionally, niosomes can be considered as more economically, chemically, and occasionally physically stable alternatives to liposomes. Niosomes can be fabricated using simple methods of preparations and from widely used surfactants in pharmaceutical technology. Many reports have discussed niosomes in terms of physicochemical properties and their applications as drug delivery systems. In this report, a brief and simplified summary of different theories of self-assembly will be given. Furthermore manufacturing methods, physical characterization techniques, bilayer membrane additives, unconventional niosomes (discomes, proniosomes, elastic and polyhedral niosomes), their recent applications as drug delivery systems, limitations and directions for future research will be discussed.

A review on the application of deep learning in system health management

NASA Astrophysics Data System (ADS)

Khan, Samir; Yairi, Takehisa

2018-07-01

Given the advancements in modern technological capabilities, having an integrated health management and diagnostic strategy becomes an important part of a system's operational life-cycle. This is because it can be used to detect anomalies, analyse failures and predict the future state based on up-to-date information. By utilising condition data and on-site feedback, data models can be trained using machine learning and statistical concepts. Once trained, the logic for data processing can be embedded on on-board controllers whilst enabling real-time health assessment and analysis. However, this integration inevitably faces several difficulties and challenges for the community; indicating the need for novel approaches to address this vexing issue. Deep learning has gained increasing attention due to its potential advantages with data classification and feature extraction problems. It is an evolving research area with diverse application domains and hence its use for system health management applications must been researched if it can be used to increase overall system resilience or potential cost benefits for maintenance, repair, and overhaul activities. This article presents a systematic review of artificial intelligence based system health management with an emphasis on recent trends of deep learning within the field. Various architectures and related theories are discussed to clarify its potential. Based on the reviewed work, deep learning demonstrates plausible benefits for fault diagnosis and prognostics. However, there are a number of limitations that hinder its widespread adoption and require further development. Attention is paid to overcoming these challenges, with future opportunities being enumerated.

Floating production platforms and their applications in the development of oil and gas fields in the South China Sea

NASA Astrophysics Data System (ADS)

Zhang, Dagang; Chen, Yongjun; Zhang, Tianyu

2014-03-01

This paper studies the current available options for floating production platforms in developing deepwater oil fields and the potential development models of future oil and gas exploration in the South China Sea. A detailed review of current deepwater platforms worldwide was performed through the examples of industry projects, and the pros and cons of each platform are discussed. Four types of platforms are currently used for the deepwater development: tension leg platform, Spar, semi-submersible platform, and the floating production system offloading. Among these, the TLP and Spar can be used for dry tree applications, and have gained popularity in recent years. The dry tree application enables the extension of the drilling application for fixed platforms into floating systems, and greatly reduces the cost and complexity of the subsea operation. Newly built wet tree semi-submersible production platforms for ultra deepwater are also getting their application, mainly due to the much needed payload for deepwater making the conversion of the old drilling semi-submersible platforms impossible. These platforms have been used in different fields around the world for different environments; each has its own advantages and disadvantages. There are many challenges with the successful use of these floating platforms. A lot of lessons have been learned and extensive experience accumulated through the many project applications. Key technologies are being reviewed for the successful use of floating platforms for field development, and potential future development needs are being discussed. Some of the technologies and experience of platform applications can be well used for the development of the South China Sea oil and gas field.

Biopharmaceutics and Therapeutic Potential of Engineered Nanomaterials

PubMed Central

Liang, Xing-Jie; Chen, Chunying; Zhao, Yuliang; Jia, Lee; Wang, Paul C.

2009-01-01

Engineered nanomaterials are at the leading edge of the rapidly developing nanosciences and are founding an important class of new materials with specific physicochemical properties different from bulk materials with the same compositions. The potential for nanomaterials is rapidly expanding with novel applications constantly being explored in different areas. The unique size-dependent properties of nanomaterials make them very attractive for pharmaceutical applications. Investigations of physical, chemical and biological properties of engineered nanomaterials have yielded valuable information. Cytotoxic effects of certain engineered nanomaterials towards malignant cells form the basis for one aspect of nanomedicine. It is inferred that size, three dimensional shape, hydrophobicity and electronic configurations make them an appealing subject in medicinal chemistry. Their unique structure coupled with immense scope for derivatization forms a base for exciting developments in therapeutics. This review article addresses the fate of absorption, distribution, metabolism and excretion (ADME) of engineered nanoparticles in vitro and in vivo. It updates the distinctive methodology used for studying the biopharmaceutics of nanoparticles. This review addresses the future potential and safety concerns and genotoxicity of nanoparticle formulations in general. It particularly emphasizes the effects of nanoparticles on metabolic enzymes as well as the parenteral or inhalation administration routes of nanoparticle formulations. This paper illustrates the potential of nanomedicine by discussing biopharmaceutics of fullerene derivatives and their suitability for diagnostic and therapeutic purposes. Future direction is discussed as well. PMID:18855608

THE APPLICATION OF A STATISTICAL DOWNSCALING PROCESS TO DERIVE 21{sup ST} CENTURY RIVER FLOW PREDICTIONS USING A GLOBAL CLIMATE SIMULATION

DOE Office of Scientific and Technical Information (OSTI.GOV)

Werth, D.; Chen, K. F.

2013-08-22

The ability of water managers to maintain adequate supplies in coming decades depends, in part, on future weather conditions, as climate change has the potential to alter river flows from their current values, possibly rendering them unable to meet demand. Reliable climate projections are therefore critical to predicting the future water supply for the United States. These projections cannot be provided solely by global climate models (GCMs), however, as their resolution is too coarse to resolve the small-scale climate changes that can affect hydrology, and hence water supply, at regional to local scales. A process is needed to ‘downscale’ themore » GCM results to the smaller scales and feed this into a surface hydrology model to help determine the ability of rivers to provide adequate flow to meet future needs. We apply a statistical downscaling to GCM projections of precipitation and temperature through the use of a scaling method. This technique involves the correction of the cumulative distribution functions (CDFs) of the GCM-derived temperature and precipitation results for the 20{sup th} century, and the application of the same correction to 21{sup st} century GCM projections. This is done for three meteorological stations located within the Coosa River basin in northern Georgia, and is used to calculate future river flow statistics for the upper Coosa River. Results are compared to the historical Coosa River flow upstream from Georgia Power Company’s Hammond coal-fired power plant and to flows calculated with the original, unscaled GCM results to determine the impact of potential changes in meteorology on future flows.« less

Applications of nanotechnology in dermatology.

PubMed

DeLouise, Lisa A

2012-03-01

What are nanoparticles and why are they important in dermatology? These questions are addressed by highlighting recent developments in the nanotechnology field that have increased the potential for intentional and unintentional nanoparticle skin exposure. The role of environmental factors in the interaction of nanoparticles with skin and the potential mechanisms by which nanoparticles may influence skin response to environmental factors are discussed. Trends emerging from recent literature suggest that the positive benefit of engineered nanoparticles for use in cosmetics and as tools for understanding skin biology and curing skin disease outweigh potential toxicity concerns. Discoveries reported in this journal are highlighted. This review begins with a general introduction to the field of nanotechnology and nanomedicine. This is followed by a discussion of the current state of understanding of nanoparticle skin penetration and their use in three therapeutic applications. Challenges that must be overcome to derive clinical benefit from the application of nanotechnology to skin are discussed last, providing perspective on the significant opportunity that exists for future studies in investigative dermatology.

Applications of Nanotechnology in Dermatology

PubMed Central

DeLouise, Lisa A.

2014-01-01

What are nanoparticles and why are they important in dermatology? These questions are addressed by highlighting recent developments in the nanotechnology field that have increased the potential for intentional and unintended nanoparticle skin exposure. The role of environmental factors in the interaction of nanoparticles with skin and the potential mechanisms by which nanoparticles may influence skin response to environmental factors are discussed. Trends emerging from recent literature suggest that the positive benefit of engineered nanoparticles for use in cosmetics and as tools for understanding skin biology and curing skin disease, out weigh potential toxicity concerns. Discoveries reported in this journal are highlighted. This review begins with a general introduction to the field of nanotechnology and nanomedicine. This is followed by a discussion of the current state of understanding of nanoparticle skin penetration and their use in three different therapeutic applications. Challenges that must be overcome to derive clinical benefit from the application of nanotechnology to skin are discussed last, providing perspective on the significant opportunity that exists for future studies in investigative dermatology. PMID:22217738

Microorganisms living on macroalgae: diversity, interactions, and biotechnological applications.

PubMed

Martin, Marjolaine; Portetelle, Daniel; Michel, Gurvan; Vandenbol, Micheline

2014-04-01

Marine microorganisms play key roles in every marine ecological process, hence the growing interest in studying their populations and functions. Microbial communities on algae remain underexplored, however, despite their huge biodiversity and the fact that they differ markedly from those living freely in seawater. The study of this microbiota and of its relationships with algal hosts should provide crucial information for ecological investigations on algae and aquatic ecosystems. Furthermore, because these microorganisms interact with algae in multiple, complex ways, they constitute an interesting source of novel bioactive compounds with biotechnological potential, such as dehalogenases, antimicrobials, and alga-specific polysaccharidases (e.g., agarases, carrageenases, and alginate lyases). Here, to demonstrate the huge potential of alga-associated organisms and their metabolites in developing future biotechnological applications, we first describe the immense diversity and density of these microbial biofilms. We further describe their complex interactions with algae, leading to the production of specific bioactive compounds and hydrolytic enzymes of biotechnological interest. We end with a glance at their potential use in medical and industrial applications.

A Primer on Audience Response Systems: Current Applications and Future Considerations

PubMed Central

Robinson, Evan

2008-01-01

Audience response systems (ARSs) are an increasingly popular tool in higher education for promoting interactivity, gathering feedback, preassessing knowledge, and assessing students' understanding of lecture concepts. Instructors in numerous disciplines are realizing the pedagogical value of these systems. Actual research on ARS usage within pharmacy education is sparse. In this paper, the health professions literature on uses of ARSs is reviewed and a primer on the issues, benefits, and potential uses within pharmacy education is presented. Future areas of educational research on ARS instructional strategies are also suggested. PMID:19002277

Trends in NASA communication satellites.

NASA Technical Reports Server (NTRS)

Sivo, J. N.; Robbins, W. H.; Stretchberry, D. M.

1972-01-01

Discussion of the potential applications of satellite communications technology in meeting the national needs in education, health care, culture, and data transfer techniques. Experiments with the NASA ATS 1, 3 and 5 spacecraft, which are conducted in an attempt to satisfy such needs, are reviewed. The future needs are also considered, covering the requirements of multiple region coverage, communications between regions, large numbers of ground terminals, multichannel capability and high quality TV pictures. The ATS F and CTS spacecraft are expected to be available in the near future to expand experiments in this field.

Development and applications of single particle orientation and rotational tracking in dynamic systems

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chen, Kuangcai

The goal of this study is to help with future data analysis and experiment designs in rotational dynamics research using DIC-based SPORT technique. Most of the current studies using DIC-based SPORT techniques are technical demonstrations. Understanding the mechanisms behind the observed rotational behaviors of the imaging probes should be the focus of the future SPORT studies. More efforts are still needed in the development of new imaging probes, particle tracking methods, instrumentations, and advanced data analysis methods to further extend the potential of DIC-based SPORT technique.

Accelerating the Translation of Nanomaterials in Biomedicine

PubMed Central

Mitragotri, Samir; Anderson, Daniel G.; Chen, Xiaoyuan; Chow, Edward K.; Ho, Dean; Kabanov, Alexander V.; Karp, Jeffrey M.; Kataoka, Kazunori; Mirkin, Chad A.; Petrosko, Sarah Hurst; Shi, Jinjun; Stevens, Molly M.; Sun, Shouheng; Teoh, Sweehin; Venkatraman, Subbu S.; Xia, Younan; Wang, Shutao; Gu, Zhen; Xu, Chenjie

2017-01-01

Due to their size and tailorable physicochemical properties, nanomaterials are an emerging class of structures utilized in biomedical applications. There are now many prominent examples of nanomaterials being used to improve human health, in areas ranging from imaging and diagnostics to therapeutics and regenerative medicine. An overview of these examples reveals several common areas of synergy and future challenges. This Nano Focus discusses the current status and future potential of promising nanomaterials and their translation from the laboratory to the clinic, by highlighting a handful of successful examples. PMID:26115196

Thermal Diffusivity and Conductivity in Ceramic Matrix Fiber Composite Materials - Literature Study

DOE Office of Scientific and Technical Information (OSTI.GOV)

R.G. Quinn

A technical literature review was conducted to gain an understanding of the state of the art method, problems, results, and future of thermal diffusivity/conductivity of matrix-fiber composites for high temperature applications. This paper summarizes the results of test method development and theory. Results from testing on various sample types are discussed with concentration on the anisotropic characteristics of matrix-fiber composites, barriers to heat flow, and notable microstructure observations. The conclusion presents some observations from the technical literature, drawbacks of current information and discusses potential needs for future testing.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fischer, W.; Shiota, T.

Two categories of NaS traction batteries will be discussed: the present battery of Asea Brown Boveri and Powerplex and potential future NaS traction batteries. A large number of our present 24 kWh - 35 kw battery has been subjected to bench and on-vehicle performance tests. Test results will be presented. Future battery types to be volume produced in the early 1990`s are discussed with regard to energy, power and shape for special applications such a passenger car and van propulsion. Examples for those batteries will be given and projected performance characteristiques will be discussed.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fischer, W.; Shiota, T.

Two categories of NaS traction batteries will be discussed: the present battery of Asea Brown Boveri and Powerplex and potential future NaS traction batteries. A large number of our present 24 kWh - 35 kw battery has been subjected to bench and on-vehicle performance tests. Test results will be presented. Future battery types to be volume produced in the early 1990's are discussed with regard to energy, power and shape for special applications such a passenger car and van propulsion. Examples for those batteries will be given and projected performance characteristiques will be discussed.

Ultrasound Elastography and MR Elastography for Assessing Liver Fibrosis: Part 2, Diagnostic Performance, Confounders, and Future Directions

PubMed Central

Tang, An; Cloutier, Guy; Szeverenyi, Nikolaus M.; Sirlin, Claude B.

2016-01-01

OBJECTIVE The purpose of the article is to review the diagnostic performance of ultrasound and MR elastography techniques for detection and staging of liver fibrosis, the main current clinical applications of elastography in the abdomen. CONCLUSION Technical and instrument-related factors and biologic and patient-related factors may constitute potential confounders of stiffness measurements for assessment of liver fibrosis. Future developments may expand the scope of elastography for monitoring liver fibrosis and predict complications of chronic liver disease. PMID:25905762

Recent Progress in Bionic Condensate Microdrop Self-Propelling Surfaces.

PubMed

Gong, Xiaojing; Gao, Xuefeng; Jiang, Lei

2017-12-01

Bionic condensate microdrop self-propelling (CMDSP) surfaces are attracting increased attention as novel, low-adhesivity superhydrophobic surfaces due to their value in fundamental research and technological innovation, e.g., for enhancing heat transfer, energy-effective antifreezing, and electrostatic energy harvesting. Here, the focus is on recent progress in bionic CMDSP surfaces. Metal-based CMDSP surfaces, which are the most promising in their respective fields, are highlighted for use in future applications. The selected topics are divided into four sections: biological prototypes, mechanism and construction rules, fabrication, and applications of metal-based CMDSP surfaces. Finally, the challenges and future development trends in bionic CMDSP surfaces are envisioned, especially the utilization of potential bionic inspiration in the design of more advanced CMDSP surfaces. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Biomolecule-based nanomaterials and nanostructures.

PubMed

Willner, Itamar; Willner, Bilha

2010-10-13

Biomolecule-nanoparticle (or carbon nanotube) hybrid systems provide new materials that combine the unique optical, electronic, or catalytic properties of the nanoelements with the recognition or biocatalytic functions of biomolecules. This article summarizes recent applications of biomolecule-nanoparticle (or carbon nanotubes) hybrid systems for sensing, synthesis of nanostructures, and for the fabrication of nanoscale devices. The use of metallic nanoparticles for the electrical contacting of redox enzymes with electrodes, and as catalytic labels for the development of electrochemical biosensors is discussed. Similarly, biomolecule-quantum dot hybrid systems are implemented for optical biosensing, and for monitoring intracellular metabolic processes. Also, the self-assembly of biomolecule-metal nanoparticle hybrids into nanostructures and functional nanodevices is presented. The future perspectives of the field are addressed by discussing future challenges and highlighting different potential applications.

A kinesthetic-tactual display concept for helicopter-pilot workload reduction

NASA Technical Reports Server (NTRS)

Gilson, R. D.; Dunn, R. S.; Sun, P.

1977-01-01

A kinesthetic-tactual (K-T) display concept is now under research and development (R & D) at the Ohio State University. It appears to offer considerable promise for useful application in helicopters by conveying control information via the sense of touch. This is a review of the overall R & D program including the original K-T display design, initial studies in automobile and fixed-wing vehicles, and feasibility experiments in a helicopter simulator. In addition to investigations of control and potential workload reduction, present efforts are directed toward establishing optimal design requirements for K-T helicopter displays. Potential applications, modes of usage, and the kinds of information that may be displayed in helicopter applications are discussed along with a brief forecast of future R & D. A brief description of the latest multi-axis laboratory prototype K-T display is also provided.

Dielectrophoresis for Biomedical Sciences Applications: A Review

PubMed Central

Abd Rahman, Nurhaslina; Ibrahim, Fatimah; Yafouz, Bashar

2017-01-01

Dielectrophoresis (DEP) is a label-free, accurate, fast, low-cost diagnostic technique that uses the principles of polarization and the motion of bioparticles in applied electric fields. This technique has been proven to be beneficial in various fields, including environmental research, polymer research, biosensors, microfluidics, medicine and diagnostics. Biomedical science research is one of the major research areas that could potentially benefit from DEP technology for diverse applications. Nevertheless, many medical science research investigations have yet to benefit from the possibilities offered by DEP. This paper critically reviews the fundamentals, recent progress, current challenges, future directions and potential applications of research investigations in the medical sciences utilizing DEP technique. This review will also act as a guide and reference for medical researchers and scientists to explore and utilize the DEP technique in their research fields. PMID:28245552

Carbon nanotube based transparent conductive films: progress, challenges, and perspectives

PubMed Central

Zhou, Ying; Azumi, Reiko

2016-01-01

Abstract Developments in the manufacturing technology of low-cost, high-quality carbon nanotubes (CNTs) are leading to increased industrial applications for this remarkable material. One of the most promising applications, CNT based transparent conductive films (TCFs), are an alternative technology in future electronics to replace traditional TCFs, which use indium tin oxide. Despite significant price competition among various TCFs, CNT-based TCFs have good potential for use in emerging flexible, stretchable and wearable optoelectronics. In this review, we summarize the recent progress in the fabrication, properties, stability and applications of CNT-based TCFs. The challenges of current CNT-based TCFs for industrial use, in comparison with other TCFs, are considered. We also discuss the potential of CNT-based TCFs, and give some possible strategies to reduce the production cost and improve their conductivity and transparency. PMID:27877899

A plastic surgeon's guide to applying smartphone technology in patient care.

PubMed

Workman, Adrienne D; Gupta, Subhas C

2013-02-01

The vast array of information technology available to plastic surgeons continues to expand. With the recent introduction of smartphone application ("app") technology to the market, the potential for incorporating both social media and app technology into daily practice exists. The authors describe and evaluate the smartphone applications most pertinent to plastic surgery. Smartphone apps from all available markets were analyzed for various factors, including popularity among general consumers, ease of use, and functionality. Using various advertising guidelines from plastic surgery societies as well as the US Food and Drug Administration, each app's content was further analyzed within the context of ethical obligations. The apps with the highest number of ratings were those offering the option to upload photos and morph each photo according to the user's own preference. The title of apps also appears to play a role in popularity. A majority of apps demonstrated the same features available on websites. The applicability of social media marketing via smartphone apps has the potential to change future patient-surgeon interactions by offering more personalized and user-friendly encounters. The role of smartphone apps is important to the future of plastic surgery as long as plastic surgeons maintain an active role in the development of these apps to ensure their value.

AMTEC: High efficiency static conversion for space power

NASA Technical Reports Server (NTRS)

Bankston, C. P.; Shirbacheh, M.

1986-01-01

Future manned and unmanned space missions will require reliable, high efficiency energy conversion systems. For a manned Mars mission, power levels in the range of 10 to 100 kWe will be needed. The Alkali Metal Thermoelectric Converter (AMTEC) is a direct energy conversion technology with the potential to meet these needs. The AMTEC is a thermally regenerative electrochemical device that derives its operation from the sodium ion conducting properties of beta-alumina solid electrolyte (BASE). To date, an efficiency of 19%, area power density of 1 W/sq cm, and a lifetime of 10,000 hours at high temperature were demonstrated in laboratory devices. Systems studies show that projected AMTEC systems equal or surpass the performance of other static or dynamic systems in applications of 1 kWe-1 MWe. Thus, the laboratory experiments and applications studies conducted to date have shown that the AMTEC posseses great potential. In order to bring this technology to the stage where prototype units can be built and operated, several technical issues must be addressed. These include the need for long life, high power electrodes, minimization of radiative parasitic losses, and high temperature seals. In summary, the evidence shows that if AMTEC is developed, it can play a significant role in future space power applications.

Multilayer scaffolds in orthopaedic tissue engineering.

PubMed

Atesok, Kivanc; Doral, M Nedim; Karlsson, Jon; Egol, Kenneth A; Jazrawi, Laith M; Coelho, Paulo G; Martinez, Amaury; Matsumoto, Tomoyuki; Owens, Brett D; Ochi, Mitsuo; Hurwitz, Shepard R; Atala, Anthony; Fu, Freddie H; Lu, Helen H; Rodeo, Scott A

2016-07-01

The purpose of this study was to summarize the recent developments in the field of tissue engineering as they relate to multilayer scaffold designs in musculoskeletal regeneration. Clinical and basic research studies that highlight the current knowledge and potential future applications of the multilayer scaffolds in orthopaedic tissue engineering were evaluated and the best evidence collected. Studies were divided into three main categories based on tissue types and interfaces for which multilayer scaffolds were used to regenerate: bone, osteochondral junction and tendon-to-bone interfaces. In vitro and in vivo studies indicate that the use of stratified scaffolds composed of multiple layers with distinct compositions for regeneration of distinct tissue types within the same scaffold and anatomic location is feasible. This emerging tissue engineering approach has potential applications in regeneration of bone defects, osteochondral lesions and tendon-to-bone interfaces with successful basic research findings that encourage clinical applications. Present data supporting the advantages of the use of multilayer scaffolds as an emerging strategy in musculoskeletal tissue engineering are promising, however, still limited. Positive impacts of the use of next generation scaffolds in orthopaedic tissue engineering can be expected in terms of decreasing the invasiveness of current grafting techniques used for reconstruction of bone and osteochondral defects, and tendon-to-bone interfaces in near future.

The future of memory

NASA Astrophysics Data System (ADS)

Marinella, M.

In the not too distant future, the traditional memory and storage hierarchy of may be replaced by a single Storage Class Memory (SCM) device integrated on or near the logic processor. Traditional magnetic hard drives, NAND flash, DRAM, and higher level caches (L2 and up) will be replaced with a single high performance memory device. The Storage Class Memory paradigm will require high speed (< 100 ns read/write), excellent endurance (> 1012), nonvolatility (retention > 10 years), and low switching energies (< 10 pJ per switch). The International Technology Roadmap for Semiconductors (ITRS) has recently evaluated several potential candidates SCM technologies, including Resistive (or Redox) RAM, Spin Torque Transfer RAM (STT-MRAM), and phase change memory (PCM). All of these devices show potential well beyond that of current flash technologies and research efforts are underway to improve the endurance, write speeds, and scalabilities to be on-par with DRAM. This progress has interesting implications for space electronics: each of these emerging device technologies show excellent resistance to the types of radiation typically found in space applications. Commercially developed, high density storage class memory-based systems may include a memory that is physically radiation hard, and suitable for space applications without major shielding efforts. This paper reviews the Storage Class Memory concept, emerging memory devices, and possible applicability to radiation hardened electronics for space.

Improvements to the Noah Land Surface Model in WRF-CMAQ, and its Application to Future Changes in the Chesapeake Bay Region

EPA Science Inventory

Regional, state, and local environmental regulatory agencies often use Eulerian meteorological and air quality models to investigate the potential impacts of climate, emissions, and land use changes on nutrient loading and air quality. The Noah land surface model in WRF could be...

Future directions for simulation of recreation use

Treesearch

David N. Cole

2005-01-01

As the case studies in Chapter 4 illustrate, simulation modeling can be a valuable tool for recreation planning and management. Although simulation modeling is already well developed for business applications, its adaptation to recreation management is less developed. Relatively few resources have been devoted to realizing its potential. Further progress is needed in...

Formation of the Creativity of Students in the Context of the Education Informatization

ERIC Educational Resources Information Center

Ramankulov, Sherzod; Usembaeva, Indira; Berdi, Dinara; Omarov, Bakhitzhan; Baimukhanbetov, Bagdat; Shektibayev, Nurdaulet

2016-01-01

Information and communication technologies are an effective means of formation of the creative potential of future physics teachers, as with their science-based application in the educational process at the university they allow fully activating learning activities of students, and provide conditions for their creative self-realization in the…

Affordances of Augmented Reality in Science Learning: Suggestions for Future Research

ERIC Educational Resources Information Center

Cheng, Kun-Hung; Tsai, Chin-Chung

2013-01-01

Augmented reality (AR) is currently considered as having potential for pedagogical applications. However, in science education, research regarding AR-aided learning is in its infancy. To understand how AR could help science learning, this review paper firstly has identified two major approaches of utilizing AR technology in science education,…

The Potential Role of Drexon LaserCards in Optical Publishing.

ERIC Educational Resources Information Center

Schwerin, Julie B.

1985-01-01

Describes Drexon LaserCard (credit card size format holding two megabytes of digital data that can be recorded at factory or by information distributors) as a viable option to rotating optical media for distribution of computer software, technical manuals, periodicals, and other document applications, and projects its future in optical publishing.…

High Speed Computing, LANs, and WAMs

NASA Technical Reports Server (NTRS)

Bergman, Larry A.; Monacos, Steve

1994-01-01

Optical fiber networks may one day offer potential capacities exceeding 10 terabits/sec. This paper describes present gigabit network techniques for distributed computing as illustrated by the CASA gigabit testbed, and then explores future all-optic network architectures that offer increased capacity, more optimized level of service for a given application, high fault tolerance, and dynamic reconfigurability.

Selected Urban Simulations and Games. IFF Working Paper WP-4.

ERIC Educational Resources Information Center

Nagelberg, Mark; Little, Dennis L.

Summary descriptions of selected urban simulations and games that have been developed outside the Institute For The Future are presented. The operating characteristics and potential applications of each model are described. These include (1) the history of development, (2) model and player requirements, (3) a description of the environment being…

77 FR 45418 - Proposed Collection; Comment Request for Form 14145

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-31

... who may be interested in working for the IRS now, or at any time in the future (potential applicants... Number of Respondents: 16,045. Estimated Time per Respondent: 4 hours 6 minutes. Estimated Total Annual Burden Hours: 66,085. The following paragraph applies to all of the collections of information covered by...

Massive Open Online Courses (MOOCs): Current Applications and Future Potential

ERIC Educational Resources Information Center

Milheim, William D.

2013-01-01

Massive Open Online Courses (or MOOCs) are the subject of numerous recent articles in "The Chronicle of Higher Education," "The New York Times," and other publications related to their increasing use by a variety of universities to reach large numbers of online students. This article describes the current state of these online…

Silicon nitride ceramic development in Thales Alenia Space : qualification achievement and further developments for future applications

NASA Astrophysics Data System (ADS)

Cornillon, L.; Devilliers, C.; Behar-Lafenetre, S.; Ait-Zaid, S.; Berroth, K.; Bravo, A. C.

2017-11-01

Dealing with ceramic materials for more than two decades, Thales Alenia Space - France has identified Silicon Nitride Si3N4 as a high potential material for the manufacturing of stiff, stable and lightweight truss structure for future large telescopes. Indeed, for earth observation or astronomic observation, space mission requires more and more telescopes with high spatial resolution, which leads to the use of large primary mirrors, and a long distance between primary and secondary mirrors. Therefore current and future large space telescopes require a huge truss structure to hold and locate precisely the mirrors. Such large structure requires very strong materials with high specific stiffness and a low coefficient of thermal expansion (CTE). Based on the silicon nitride performances and on the know how of FCT Ingenieurkeramik to manufacture complex parts, Thales Alenia Space (TAS) has engaged, in cooperation with FCT, activities to develop and qualify silicon nitride parts for other applications for space projects.

Silicon nitride ceramic development in Thales Alenia Space: qualification achiement and further developments for future applications

NASA Astrophysics Data System (ADS)

Cornillon, L.; Devilliers, C.; Behar-Lafenetre, S.; Ait-Zaid, S.; Berroth, K.; Bravo, A. C.

2017-11-01

Dealing with ceramic materials for more than two decades, Thales Alenia Space - France has identified Silicon Nitride Si3N4 as a high potential material for the manufacturing of stiff, stable and lightweight truss structure for future large telescopes. Indeed, for earth observation or astronomic observation, space mission requires more and more telescopes with high spatial resolution, which leads to the use of large primary mirrors, and a long distance between primary and secondary mirrors. Therefore current and future large space telescopes require a huge truss structure to hold and locate precisely the mirrors. Such large structure requires very strong materials with high specific stiffness and a low coefficient of thermal expansion (CTE). Based on the silicon nitride performances and on the know how of FCT Ingenieurkeramik to manufacture complex parts, Thales Alenia Space (TAS) has engaged, in cooperation with FCT, activities to develop and qualify silicon nitride parts for other applications for space projects.

Current Status of NASA's NEXT-C Ion Propulsion System Development Project

NASA Technical Reports Server (NTRS)

Shastry, Rohit; Soulas, George; Aulisio, Michael; Schmidt, George

2017-01-01

NASA's Evolutionary Xenon Thruster (NEXT) is a 7-kW class gridded ion thruster-based propulsion system that was initially developed from 2002 to 2012 under NASAs In-Space Propulsion Technology Program to meet future science mission requirements. In 2015, a contract was awarded to Aerojet Rocketdyne, with subcontractor ZIN Technologies, to design, build and test two NEXT flight thrusters and two power processing units that would be available for use on future NASA science missions. Because an additional goal of this contract is to take steps towards offering NEXT as a commercialized system, it is called the NEXT-Commercial project, or NEXT-C. This paper reviews the capabilities of the NEXT-C system, status of the NEXT-C project, and the forward plan to build, test, and deliver flight hardware in support of future NASA and commercial applications. It also briefly addresses some of the potential applications that could utilize the hardware developed and built by the project.

Recent Development Activities and Future Mission Applications of NASA's Evolutionary Xenon Thruster (NEXT)

NASA Technical Reports Server (NTRS)

Patterson, Michael J.; Pencil, Eric J.

2014-01-01

NASAs Evolutionary Xenon Thruster (NEXT) project is developing next generation ion propulsion technologies to enhance the performance and lower the costs of future NASA space science missions. This is being accomplished by producing Engineering Model (EM) and Prototype Model (PM) components, validating these via qualification-level and integrated system testing, and preparing the transition of NEXT technologies to flight system development. This presentation is a follow-up to the NEXT project overviews presented in 2009-2010. It reviews the status of the NEXT project, presents the current system performance characteristics, and describes planned activities in continuing the transition of NEXT technology to a first flight. In 2013 a voluntary decision was made to terminate the long duration test of the NEXT thruster, given the thruster design has exceeded all expectations by accumulating over 50,000 hours of operation to demonstrate around 900 kg of xenon throughput. Besides its promise for upcoming NASA science missions, NEXT has excellent potential for future commercial and international spacecraft applications.

Applications of ICA and fractal dimension in sEMG signal processing for subtle movement analysis: a review.

PubMed

Naik, Ganesh R; Arjunan, Sridhar; Kumar, Dinesh

2011-06-01

The surface electromyography (sEMG) signal separation and decphompositions has always been an interesting research topic in the field of rehabilitation and medical research. Subtle myoelectric control is an advanced technique concerned with the detection, processing, classification, and application of myoelectric signals to control human-assisting robots or rehabilitation devices. This paper reviews recent research and development in independent component analysis and Fractal dimensional analysis for sEMG pattern recognition, and presents state-of-the-art achievements in terms of their type, structure, and potential application. Directions for future research are also briefly outlined.

Trust evaluation in health information on the World Wide Web.

PubMed

Moturu, Sai T; Liu, Huan; Johnson, William G

2008-01-01

The impact of health information on the web is mounting and with the Health 2.0 revolution around the corner, online health promotion and management is becoming a reality. User-generated content is at the core of this revolution and brings to the fore the essential question of trust evaluation, a pertinent problem for health applications in particular. Evolving Web 2.0 health applications provide abundant opportunities for research. We identify these applications, discuss the challenges for trust assessment, characterize conceivable variables, list potential techniques for analysis, and provide a vision for future research.

Transcranial magnetic stimulation: physics, electrophysiology, and applications.

PubMed

Fatemi-Ardekani, Ali

2008-01-01

Transcranial magnetic stimulation (TMS) is a noninvasive technique used to stimulate the brain. This review will examine the fundamental principles of physics upon which magnetic stimulation is based, the design considerations of the TMS device, and hypotheses about its electrophysiological effects resulting in neuromodulation. TMS is valuable in neurophysiology research and has significant therapeutic potential in clinical neurology and psychiatry. While TMS can modify neuronal currents in the brain, its underlying mechanism remains unknown. Salient applications are included and some suggestions are outlined for future development of magnetic stimulators that could lead to more effective neuronal stimulation and therefore better therapeutic and diagnostic applications.

Polarimetric Multispectral Imaging Technology

NASA Technical Reports Server (NTRS)

Cheng, L.-J.; Chao, T.-H.; Dowdy, M.; Mahoney, C.; Reyes, G.

1993-01-01

The Jet Propulsion Laboratory is developing a remote sensing technology on which a new generation of compact, lightweight, high-resolution, low-power, reliable, versatile, programmable scientific polarimetric multispectral imaging instruments can be built to meet the challenge of future planetary exploration missions. The instrument is based on the fast programmable acousto-optic tunable filter (AOTF) of tellurium dioxide (TeO2) that operates in the wavelength range of 0.4-5 microns. Basically, the AOTF multispectral imaging instrument measures incoming light intensity as a function of spatial coordinates, wavelength, and polarization. Its operation can be in either sequential, random access, or multiwavelength mode as required. This provides observation flexibility, allowing real-time alternation among desired observations, collecting needed data only, minimizing data transmission, and permitting implementation of new experiments. These will result in optimization of the mission performance with minimal resources. Recently we completed a polarimetric multispectral imaging prototype instrument and performed outdoor field experiments for evaluating application potentials of the technology. We also investigated potential improvements on AOTF performance to strengthen technology readiness for applications. This paper will give a status report on the technology and a prospect toward future planetary exploration.

Time-Resolved Diffuse Optical Spectroscopy and Imaging Using Solid-State Detectors: Characteristics, Present Status, and Research Challenges.

PubMed

Alayed, Mrwan; Deen, M Jamal

2017-09-14

Diffuse optical spectroscopy (DOS) and diffuse optical imaging (DOI) are emerging non-invasive imaging modalities that have wide spread potential applications in many fields, particularly for structural and functional imaging in medicine. In this article, we review time-resolved diffuse optical imaging (TR-DOI) systems using solid-state detectors with a special focus on Single-Photon Avalanche Diodes (SPADs) and Silicon Photomultipliers (SiPMs). These TR-DOI systems can be categorized into two types based on the operation mode of the detector (free-running or time-gated). For the TR-DOI prototypes, the physical concepts, main components, figures-of-merit of detectors, and evaluation parameters are described. The performance of TR-DOI prototypes is evaluated according to the parameters used in common protocols to test DOI systems particularly basic instrumental performance (BIP). In addition, the potential features of SPADs and SiPMs to improve TR-DOI systems and expand their applications in the foreseeable future are discussed. Lastly, research challenges and future developments for TR-DOI are discussed for each component in the prototype separately and also for the entire system.

Potential benefits from a successful solar thermal program

NASA Technical Reports Server (NTRS)

Terasawa, K. L.; Gates, W. R.

1982-01-01

Solar energy systems were investigated which complement nuclear and coal technologies as a means of reducing the U.S. dependence on imported petroleum. Solar Thermal Energy Systems (STES) represents an important category of solar energy technologies. STES can be utilized in a broad range of applications servicing a variety of economic sectors, and they can be deployed in both near-term and long-term markets. The net present value of the energy cost savings attributable to electric utility and IPH applications of STES were estimated for a variety of future energy cost scenarios and levels of R&D success. This analysis indicated that the expected net benefits of developing an STES option are significantly greater than the expected costs of completing the required R&D. In addition, transportable fuels and chemical feedstocks represent a substantial future potential market for STES. Due to the basic nature of this R&D activity, however, it is currently impossible to estimate the value of STES in these markets. Despite this fact, private investment in STES R&D is not anticipated due to the high level of uncertainty characterizing the expected payoffs.

Electric field effect in multilayer Cr2Ge2Te6: a ferromagnetic 2D material

NASA Astrophysics Data System (ADS)

Xing, Wenyu; Chen, Yangyang; Odenthal, Patrick M.; Zhang, Xiao; Yuan, Wei; Su, Tang; Song, Qi; Wang, Tianyu; Zhong, Jiangnan; Jia, Shuang; Xie, X. C.; Li, Yan; Han, Wei

2017-06-01

The emergence of two-dimensional (2D) materials has attracted a great deal of attention due to their fascinating physical properties and potential applications for future nano-electronic devices. Since the first isolation of graphene, a Dirac material, a large family of new functional 2D materials have been discovered and characterized, including insulating 2D boron nitride, semiconducting 2D transition metal dichalcogenides and black phosphorus, and superconducting 2D bismuth strontium calcium copper oxide, molybdenum disulphide and niobium selenide, etc. Here, we report the identification of ferromagnetic thin flakes of Cr2Ge2Te6 (CGT) with thickness down to a few nanometers, which provides a very important piece to the van der Waals structures consisting of various 2D materials. We further demonstrate the giant modulation of the channel resistance of 2D CGT devices via electric field effect. Our results illustrate the gate voltage tunability of 2D CGT and the potential of CGT, a ferromagnetic 2D material, as a new functional quantum material for applications in future nanoelectronics and spintronics.

Quintuple-modality (SERS-MRI-CT-TPL-PTT) plasmonic nanoprobe for theranostics

NASA Astrophysics Data System (ADS)

Liu, Yang; Chang, Zheng; Yuan, Hsiangkuo; Fales, Andrew M.; Vo-Dinh, Tuan

2013-11-01

A unique quintuple-modality theranostic nanoprobe (QMT) is developed with gold nanostars for surface-enhanced Raman scattering (SERS), magnetic resonance imaging (MRI), computed tomography (CT), two-photon luminescence (TPL) imaging and photothermal therapy (PTT). The synthesized gold nanostars were tagged with a SERS reporter and linked with an MRI contrast agent Gd3+. In vitro experiments demonstrated the developed QMT nanoprobe to be a potential theranostic agent for future biomedical applications.A unique quintuple-modality theranostic nanoprobe (QMT) is developed with gold nanostars for surface-enhanced Raman scattering (SERS), magnetic resonance imaging (MRI), computed tomography (CT), two-photon luminescence (TPL) imaging and photothermal therapy (PTT). The synthesized gold nanostars were tagged with a SERS reporter and linked with an MRI contrast agent Gd3+. In vitro experiments demonstrated the developed QMT nanoprobe to be a potential theranostic agent for future biomedical applications. Electronic supplementary information (ESI) available: Details of experimental section, characterization details and relaxivity curve of developed QMT nanoprobe in water at 1.5 T magnetic filed strength. See DOI: 10.1039/c3nr03762b

Artificial intelligence in diagnosis of obstructive lung disease: current status and future potential.

PubMed

Das, Nilakash; Topalovic, Marko; Janssens, Wim

2018-03-01

The application of artificial intelligence in the diagnosis of obstructive lung diseases is an exciting phenomenon. Artificial intelligence algorithms work by finding patterns in data obtained from diagnostic tests, which can be used to predict clinical outcomes or to detect obstructive phenotypes. The purpose of this review is to describe the latest trends and to discuss the future potential of artificial intelligence in the diagnosis of obstructive lung diseases. Machine learning has been successfully used in automated interpretation of pulmonary function tests for differential diagnosis of obstructive lung diseases. Deep learning models such as convolutional neural network are state-of-the art for obstructive pattern recognition in computed tomography. Machine learning has also been applied in other diagnostic approaches such as forced oscillation test, breath analysis, lung sound analysis and telemedicine with promising results in small-scale studies. Overall, the application of artificial intelligence has produced encouraging results in the diagnosis of obstructive lung diseases. However, large-scale studies are still required to validate current findings and to boost its adoption by the medical community.

High temperature superconducting magnetic energy storage for future NASA missions

NASA Technical Reports Server (NTRS)

Faymon, Karl A.; Rudnick, Stanley J.

1988-01-01

Several NASA sponsored studies based on 'conventional' liquid helium temperature level superconductivity technology have concluded that superconducting magnetic energy storage has considerable potential for space applications. The advent of high temperature superconductivity (HTSC) may provide additional benefits over conventional superconductivity technology, making magnetic energy storage even more attractive. The proposed NASA space station is a possible candidate for the application of HTSC energy storage. Alternative energy storage technologies for this and other low Earth orbit missions are compared.

Inorganic Nanoparticles in Cancer Therapy

PubMed Central

Bhattacharyya, Sanjib; Kudgus, Rachel A.; Bhattacharya, Resham; Mukherjee, Priyabrata

2011-01-01

Nanotechnology is an evolving field with enormous potential for biomedical applications. The growing interest to use inorganic nanoparticles in medicine is due to the unique size and shape-dependent optoelectronic properties. Herein, we will focus on gold, silver and platinum nanoparticles, discussing recent developments for therapeutic applications with regard to cancer in terms of nanoparticles being used as a delivery vehicle as well as therapeutic agents. We will also discuss some of the key challenges to be addressed in future studies. PMID:21104301

Summary and overview

NASA Technical Reports Server (NTRS)

1982-01-01

The merits, shortcomings, and future outlook of thermal IR remote sensing are appraised from a philosophical and speculative point of view in the light of the HCMM experiments. Two key questions stemming from HCMM addressed are: thermal remote sensing from space platforms now on a solid foundation in terms of demonstrated applications of real utility as well as theory, and where should NASA's research be focused in thermal remote sensing and are the potential applications sufficient to justify inclusion of thermal sensors in later generations of Earth resources satellites.

Neurocriminology: implications for the punishment, prediction and prevention of criminal behaviour.

PubMed

Glenn, Andrea L; Raine, Adrian

2014-01-01

Criminal behaviour and violence are increasingly viewed as worldwide public health problems. A growing body of knowledge shows that criminal behaviour has a neurobiological basis, and this has intensified judicial interest in the potential application of neuroscience to criminal law. It also gives rise to important questions. What are the implications of such application for predicting future criminal behaviour and protecting society? Can it be used to prevent violence? And what are the implications for the way offenders are punished?

In-Space Propulsion Technology Products Ready for Infusion on NASA's Future Science Missions

NASA Technical Reports Server (NTRS)

Anderson, David J.; Pencil, Eric; Peterson, Todd; Dankanich, John; Munk, Michele M.

2012-01-01

Since 2001, the In-Space Propulsion Technology (ISPT) program has been developing and delivering in-space propulsion technologies that will enable or enhance NASA robotic science missions. These in-space propulsion technologies are applicable, and potentially enabling, for future NASA flagship and sample return missions currently being considered. They have a broad applicability to future competed mission solicitations. The high-temperature Advanced Material Bipropellant Rocket (AMBR) engine, providing higher performance for lower cost, was completed in 2009. Two other ISPT technologies are nearing completion of their technology development phase: 1) NASA s Evolutionary Xenon Thruster (NEXT) ion propulsion system, a 0.6-7 kW throttle-able gridded ion system; and 2) Aerocapture technology development with investments in a family of thermal protection system (TPS) materials and structures; guidance, navigation, and control (GN&C) models of blunt-body rigid aeroshells; aerothermal effect models; and atmospheric models for Earth, Titan, Mars and Venus. This paper provides status of the technology development, applicability, and availability of in-space propulsion technologies that have recently completed their technology development and will be ready for infusion into NASA s Discovery, New Frontiers, SMD Flagship, or technology demonstration missions.

In-Space Propulsion Technology Products for NASA's Future Science and Exploration Missions

NASA Technical Reports Server (NTRS)

Anderson, David J.; Pencil, Eric; Peterson, Todd; Dankanich, John; Munk, Michelle M.

2011-01-01

Since 2001, the In-Space Propulsion Technology (ISPT) project has been developing and delivering in-space propulsion technologies that will enable or enhance NASA robotic science missions. These in-space propulsion technologies are applicable, and potentially enabling, for future NASA flagship and sample return missions currently being considered, as well as having broad applicability to future competed mission solicitations. The high-temperature Advanced Material Bipropellant Rocket (AMBR) engine providing higher performance for lower cost was completed in 2009. Two other ISPT technologies are nearing completion of their technology development phase: 1) NASA's Evolutionary Xenon Thruster (NEXT) ion propulsion system, a 0.6-7 kW throttle-able gridded ion system; and 2) Aerocapture technology development with investments in a family of thermal protection system (TPS) materials and structures; guidance, navigation, and control (GN&C) models of blunt-body rigid aeroshells; aerothermal effect models: and atmospheric models for Earth, Titan, Mars and Venus. This paper provides status of the technology development, applicability, and availability of in-space propulsion technologies that have recently completed their technology development and will be ready for infusion into NASA s Discovery, New Frontiers, Science Mission Directorate (SMD) Flagship, and Exploration technology demonstration missions

Predicting Node Degree Centrality with the Node Prominence Profile

PubMed Central

Yang, Yang; Dong, Yuxiao; Chawla, Nitesh V.

2014-01-01

Centrality of a node measures its relative importance within a network. There are a number of applications of centrality, including inferring the influence or success of an individual in a social network, and the resulting social network dynamics. While we can compute the centrality of any node in a given network snapshot, a number of applications are also interested in knowing the potential importance of an individual in the future. However, current centrality is not necessarily an effective predictor of future centrality. While there are different measures of centrality, we focus on degree centrality in this paper. We develop a method that reconciles preferential attachment and triadic closure to capture a node's prominence profile. We show that the proposed node prominence profile method is an effective predictor of degree centrality. Notably, our analysis reveals that individuals in the early stage of evolution display a distinctive and robust signature in degree centrality trend, adequately predicted by their prominence profile. We evaluate our work across four real-world social networks. Our findings have important implications for the applications that require prediction of a node's future degree centrality, as well as the study of social network dynamics. PMID:25429797

Flight program language requirements. Volume 2: Requirements and evaluations

NASA Technical Reports Server (NTRS)

1972-01-01

The efforts and results are summarized for a study to establish requirements for a flight programming language for future onboard computer applications. Several different languages were available as potential candidates for future NASA flight programming efforts. The study centered around an evaluation of the four most pertinent existing aerospace languages. Evaluation criteria were established, and selected kernels from the current Saturn 5 and Skylab flight programs were used as benchmark problems for sample coding. An independent review of the language specifications incorporated anticipated future programming requirements into the evaluation. A set of detailed language requirements was synthesized from these activities. The details of program language requirements and of the language evaluations are described.

Potential of Sub-GHz Wireless for Future IoT Wearables and Design of Compact 915 MHz Antenna

PubMed Central

Di Serio, Adolfo; Barton, John; Rodencal, Matthew; Dunlop, Gary; O’Flynn, Brendan

2017-01-01

Internet of Things (IoT) technology is rapidly emerging in medical applications as it offers the possibility of lower-cost personalized healthcare monitoring. At the present time, the 2.45 GHz band is in widespread use for these applications but in this paper, the authors investigate the potential of the 915 MHz ISM band in implementing future, wearable IoT devices. The target sensor is a wrist-worn wireless heart rate and arterial oxygen saturation (SpO2) monitor with the goal of providing efficient wireless functionality and long battery lifetime using a commercial Sub-GHz low-power radio transceiver. A detailed analysis of current consumption for various wireless protocols is also presented and analyzed. A novel 915 MHz antenna design of compact size is reported that has good resilience to detuning by the human body. The antenna also incorporates a matching network to meet the challenging bandwidth requirements and is fabricated using standard, low-cost FR-4 material. Full-Wave EM simulations are presented for the antenna placed in both free-space and on-body cases. A prototype antenna is demonstrated and has dimensions of 44 mm × 28 mm × 1.6 mm. The measured results at 915 MHz show a 10 dB return loss bandwidth of 55 MHz, a peak realized gain of −2.37 dBi in free-space and −6.1 dBi on-body. The paper concludes by highlighting the potential benefits of 915 MHz operation for future IoT devices. PMID:29271941

Potential of Sub-GHz Wireless for Future IoT Wearables and Design of Compact 915 MHz Antenna.

PubMed

Di Serio, Adolfo; Buckley, John; Barton, John; Newberry, Robert; Rodencal, Matthew; Dunlop, Gary; O'Flynn, Brendan

2017-12-22

Internet of Things (IoT) technology is rapidly emerging in medical applications as it offers the possibility of lower-cost personalized healthcare monitoring. At the present time, the 2.45 GHz band is in widespread use for these applications but in this paper, the authors investigate the potential of the 915 MHz ISM band in implementing future, wearable IoT devices. The target sensor is a wrist-worn wireless heart rate and arterial oxygen saturation (SpO2) monitor with the goal of providing efficient wireless functionality and long battery lifetime using a commercial Sub-GHz low-power radio transceiver. A detailed analysis of current consumption for various wireless protocols is also presented and analyzed. A novel 915 MHz antenna design of compact size is reported that has good resilience to detuning by the human body. The antenna also incorporates a matching network to meet the challenging bandwidth requirements and is fabricated using standard, low-cost FR-4 material. Full-Wave EM simulations are presented for the antenna placed in both free-space and on-body cases. A prototype antenna is demonstrated and has dimensions of 44 mm × 28 mm × 1.6 mm. The measured results at 915 MHz show a 10 dB return loss bandwidth of 55 MHz, a peak realized gain of - 2.37 dBi in free-space and - 6.1 dBi on-body. The paper concludes by highlighting the potential benefits of 915 MHz operation for future IoT devices.

Fuel Cell Activities at the NASA Glenn Research Center

NASA Technical Reports Server (NTRS)

Kohout, Lisa L.; Lyons, Valerie (Technical Monitor)

2002-01-01

Fuel cells have a long history in space applications and may have potential application in aeronautics as well. A fuel cell is an electrochemical energy conversion device that directly transforms the chemical energy of a fuel and oxidant into electrical energy. Alkaline fuel cells have been the mainstay of the U.S. space program, providing power for the Apollo missions and the Space Shuttle. However, Proton Exchange Membrane (PEM) fuel cells offer potential benefits over alkaline systems and are currently under development for the next generation Reusable Launch Vehicle (RLV). Furthermore, primary and regenerative systems utilizing PEM technology are also being considered for future space applications such as surface power and planetary aircraft. In addition to these applications, the NASA Glenn Research Center is currently studying the feasibility of the use of both PEM and solid oxide fuel cells for low- or zero-emission electric aircraft propulsion. These types of systems have potential applications for high altitude environmental aircraft, general aviation and commercial aircraft, and high attitude airships. NASA Glenn has a unique set of capabilities and expertise essential to the successful development of advanced fuel cell power systems for space and aeronautics applications. NASA Glenn's role in past fuel cell development programs as well as current activities to meet these new challenges will be presented

The potential application and challenge of powerful CRISPR/Cas9 system in cardiovascular research.

PubMed

Li, Yangxin; Song, Yao-Hua; Liu, Bin; Yu, Xi-Yong

2017-01-15

CRISPR/Cas9 is a precision-guided munition found in bacteria to fight against invading viruses. This technology has enormous potential applications, including altering genes in both somatic and germ cells, as well as generating knockout animals. Compared to other gene editing techniques such as zinc finger nucleases and TALENS, CRISPR/Cas9 is much easier to use and highly efficient. Importantly, the multiplex capacity of this technology allows multiple genes to be edited simultaneously. CRISPR/Cas9 also has the potential to prevent and cure human diseases. In this review, we wish to highlight some key points regarding the future prospect of using CRISPR/Cas9 as a powerful tool for cardiovascular research, and as a novel therapeutic strategy to treat cardiovascular diseases. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

Building renewable electricity supply in Bangladesh

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fulton, L.M.

1997-12-31

Bangladesh is experiencing a severe electric power capacity crisis that is only likely to worsen over the next 15 years. Further, over 80% of Bangladesh`s population still lives with no electricity, and the rate of grid expansion to connect rural villages is threatened by the looming capacity shortage. There are a number of underlying reasons for the crisis, but ultimately the country lacks the fossil fuel resources required to conduct a large scale grid-expansion program. Alternative approaches to electrifying the country must be found. This paper outlines the prospects for wind and solar power in Bangladesh, and estimates the potentialmore » for commercial applications now and in the future. This includes a technical assessment, a market assessment, an environmental assessment, and a policy assessment. The paper concludes that Bangladesh holds the potential to cost-effectively meet a significant fraction of its future electricity demand through the use of renewable generation technologies, possibly adding as much renewable capacity as the current overall electric power capacity of the country. Many parts of the country have favorable solar and wind conditions and there are many potentially cost-effective applications. But the country must develop a policy framework that allows and encourages private investors to develop renewable energy projects in order to realize the enormous potential of renewables.« less

Size-Dependent Optoelectronic Properties and Controlled Doping of Semiconductor Quantum Dots

NASA Astrophysics Data System (ADS)

Engel, Jesse Hart

Given a rapidly developing world, the need exists for inexpensive renewable energy alternatives to help avoid drastic climate change. Photovoltaics have the potential to fill the energy needs of the future, but significant cost decreases are necessary for widespread adoption. Semiconductor nanocrystals, also known as quantum dots, are a nascent technology with long term potential to enable inexpensive and high efficiency photovoltaics. When deposited as a film, quantum dots form unique nanocomposites whose electronic and optical properties can be broadly tuned through manipulation of their individual constituents. The contents of this thesis explore methods to understand and optimize the optoelectronic properties of PbSe quantum dot films for use in photovoltaic applications. Systematic optimization of photovoltaic performance is demonstrated as a function of nanocrystal size, establishing the potential for utilizing extreme quantum confinement to improve device energetics and alignment. Detailed investigations of the mechanisms of electrical transport are performed, revealing that electronic coupling in quantum dot films is significantly less than often assumed based on optical shifts. A method is proposed to employ extended regions of built-in electrical field, through controlled doping, to sidestep issues of poor transport. To this end, treatments with chemical redox agents are found to effect profound and reversible doping within nanocrystal films, sufficient to enable their use as chemical sensors, but lacking the precision required for optoelectronic applications. Finally, a novel doping method employing "redox buffers" is presented to enact precise, stable, and reversible charge-transfer doping in porous semiconductor films. An example of oxidatively doping PbSe quantum dot thin films is presented, and the future potential for redox buffers in photovoltaic applications is examined.

NASA In-Space Propulsion Technologies and Their Infusion Potential

NASA Technical Reports Server (NTRS)

Anderson, David J.; Pencil,Eric J.; Peterson, Todd; Vento, Daniel; Munk, Michelle M.; Glaab, Louis J.; Dankanich, John W.

2012-01-01

The In-Space Propulsion Technology (ISPT) program has been developing in-space propulsion technologies that will enable or enhance NASA robotic science missions. The ISPT program is currently developing technology in four areas that include Propulsion System Technologies (Electric and Chemical), Entry Vehicle Technologies (Aerocapture and Earth entry vehicles), Spacecraft Bus and Sample Return Propulsion Technologies (components and ascent vehicles), and Systems/Mission Analysis. Three technologies are ready for flight infusion: 1) the high-temperature Advanced Material Bipropellant Rocket (AMBR) engine providing higher performance; 2) NASA s Evolutionary Xenon Thruster (NEXT) ion propulsion system, a 0.6-7 kW throttle-able gridded ion system; and 3) Aerocapture technology development with investments in a family of thermal protection system (TPS) materials and structures; guidance, navigation, and control (GN&C) models of blunt-body rigid aeroshells; and aerothermal effect models. Two component technologies that will be ready for flight infusion in the near future will be Advanced Xenon Flow Control System, and ultra-lightweight propellant tank technologies. Future focuses for ISPT are sample return missions and other spacecraft bus technologies like: 1) Mars Ascent Vehicles (MAV); 2) multi-mission technologies for Earth Entry Vehicles (MMEEV) for sample return missions; and 3) electric propulsion for sample return and low cost missions. These technologies are more vehicle-focused, and present a different set of technology infusion challenges. While the Systems/Mission Analysis area is focused on developing tools and assessing the application of propulsion technologies to a wide variety of mission concepts. These in-space propulsion technologies are applicable, and potentially enabling for future NASA Discovery, New Frontiers, and sample return missions currently under consideration, as well as having broad applicability to potential Flagship missions. This paper provides a brief overview of the ISPT program, describing the development status and technology infusion readiness of in-space propulsion technologies in the areas of electric propulsion, aerocapture, Earth entry vehicles, propulsion components, Mars ascent vehicle, and mission/systems analysis.

Quantifying the transmission potential of pandemic influenza

NASA Astrophysics Data System (ADS)

Chowell, Gerardo; Nishiura, Hiroshi

2008-03-01

This article reviews quantitative methods to estimate the basic reproduction number of pandemic influenza, a key threshold quantity to help determine the intensity of interventions required to control the disease. Although it is difficult to assess the transmission potential of a probable future pandemic, historical epidemiologic data is readily available from previous pandemics, and as a reference quantity for future pandemic planning, mathematical and statistical analyses of historical data are crucial. In particular, because many historical records tend to document only the temporal distribution of cases or deaths (i.e. epidemic curve), our review focuses on methods to maximize the utility of time-evolution data and to clarify the detailed mechanisms of the spread of influenza. First, we highlight structured epidemic models and their parameter estimation method which can quantify the detailed disease dynamics including those we cannot observe directly. Duration-structured epidemic systems are subsequently presented, offering firm understanding of the definition of the basic and effective reproduction numbers. When the initial growth phase of an epidemic is investigated, the distribution of the generation time is key statistical information to appropriately estimate the transmission potential using the intrinsic growth rate. Applications of stochastic processes are also highlighted to estimate the transmission potential using similar data. Critically important characteristics of influenza data are subsequently summarized, followed by our conclusions to suggest potential future methodological improvements.

Re-thinking the role of radiometal isotopes: Towards a future concept for theranostic radiopharmaceuticals.

PubMed

Notni, Johannes; Wester, Hans-Jürgen

2018-03-01

The potential and future role of certain metal radionuclides, for example, 44 Sc, 89 Zr, 86 Y, 64 Cu, 68 Ga, 177 Lu, 225 Ac, and 213 Bi, and several terbium isotopes has been controversially discussed in the past decades. Furthermore, the possible benefits of "matched pairs" of isotopes for tandem applications of diagnostics and therapeutics (theranostics) have been emphasized, while such approaches still have not made their way into routine clinical practice. Analysis of bibliographical data illustrates how popularity of certain nuclides has been promoted by cycles of availability and applications. We furthermore discuss the different practical requirements for diagnostic and therapeutic radiopharmaceuticals and the resulting consequences for efficient development of clinically useful pairs of radionuclide theranostics, with particular emphasis on the underlying economical factors. Based on an exemplary assessment of overall production costs for 68 Ga and 18 F radiopharmaceuticals, we venture a look into the future of theranostics and predict that high-throughput PET applications, that is, diagnosis of frequent conditions, will ultimately rely on 18 F tracers. PET radiometals will occupy a niche in the clinical low-throughput sector (diagnosis of rare diseases), but above all, dominate preclinical research and clinical translation. Matched isotope pairs will be of lesser relevance for theranostics but may become important for future PET-based therapeutic dosimetry. Copyright © 2017 John Wiley & Sons, Ltd.

How to deal with climate change uncertainty in the planning of engineering systems

NASA Astrophysics Data System (ADS)

Spackova, Olga; Dittes, Beatrice; Straub, Daniel

2016-04-01

The effect of extreme events such as floods on the infrastructure and built environment is associated with significant uncertainties: These include the uncertain effect of climate change, uncertainty on extreme event frequency estimation due to limited historic data and imperfect models, and, not least, uncertainty on future socio-economic developments, which determine the damage potential. One option for dealing with these uncertainties is the use of adaptable (flexible) infrastructure that can easily be adjusted in the future without excessive costs. The challenge is in quantifying the value of adaptability and in finding the optimal sequence of decision. Is it worth to build a (potentially more expensive) adaptable system that can be adjusted in the future depending on the future conditions? Or is it more cost-effective to make a conservative design without counting with the possible future changes to the system? What is the optimal timing of the decision to build/adjust the system? We develop a quantitative decision-support framework for evaluation of alternative infrastructure designs under uncertainties, which: • probabilistically models the uncertain future (trough a Bayesian approach) • includes the adaptability of the systems (the costs of future changes) • takes into account the fact that future decisions will be made under uncertainty as well (using pre-posterior decision analysis) • allows to identify the optimal capacity and optimal timing to build/adjust the infrastructure. Application of the decision framework will be demonstrated on an example of flood mitigation planning in Bavaria.

DOE Office of Scientific and Technical Information (OSTI.GOV)

David Kisailus; Lara Estroff; Himadri S. Gupta

The technical presentations and discussions at this symposium disseminated and assessed current research and defined future directions in biomaterials research, with a focus on structure-function relationships in biological and biomimetic composites. The invited and contributed talks covered a diverse range of topics from fundamental biology, physics, chemistry, and materials science to potential applications in developing areas such as light-weight composites, multifunctional and smart materials, biomedical engineering, and nanoscaled sensors. The invited speakers were chosen to create a stimulating program with a mixture of established and junior faculty, industrial and academic researchers, and American and international experts in the field. Thismore » symposium served as an excellent introduction to the area for younger scientists (graduate students and post-doctoral researchers). Direct interactions between participants also helped to promote potential future collaborations involving multiple disciplines and institutions.« less

Nanotechnology in dentistry: Present and future

PubMed Central

Bhardwaj, Archana; Bhardwaj, Abhishek; Misuriya, Abhinav; Maroli, Sohani; Manjula, S; Singh, Arvind Kumar

2014-01-01

Nanotechnology is the manipulation of matter on the molecular and atomic levels. It has the potential to bring enormous changes into the fields of medicine and dentistry. A day may soon come when nanodentistry will succeed in maintaining near-perfect oral health through the aid of nanorobotics, nanomaterials and biotechnology. However, as with all developments, it may also pose a risk for misuse. Time, economical and technical resources, and human needs will determine the direction this revolutionizing development may take. This article reviews the current status and the potential clinical applications of nanotechnology, nanaomedicine and nanodentistry. How to cite the article: Bhardwaj A, Bhardwaj A, Misuriya A, Maroli S, Manjula S, Singh AK. Nanotechnology in dentistry: Present and future. J Int Oral Health 2013;6(1):121-6. PMID:24653616

Expert system applications for army vehicle diagnostics

DOE Office of Scientific and Technical Information (OSTI.GOV)

Halle, R.F.

1987-01-01

Bulky manuals, limited training procedures, and complex Automatic Test Equipment are but a few of the problems a mechanic must face when trying to repair many of the military's new and highly complex vehicle systems. Recent technological advances in Expert Systms has given the mechanic the potential to solve many of these problems and to actually enhance his maintenance proficiency. This paper describes both the history of and the future potential of the Expert System and how it could impact on the present military maintenance system.

Simulators and virtual reality in surgical education.

PubMed

Chou, Betty; Handa, Victoria L

2006-06-01

This article explores the pros and cons of virtual reality simulators, their abilities to train and assess surgical skills, and their potential future applications. Computer-based virtual reality simulators and more conventional box trainers are compared and contrasted. The virtual reality simulator provides objective assessment of surgical skills and immediate feedback further to enhance training. With this ability to provide standardized, unbiased assessment of surgical skills, the virtual reality trainer has the potential to be a tool for selecting, instructing, certifying, and recertifying gynecologists.

Basic mechanisms of gabitril (tiagabine) and future potential developments.

PubMed

Meldrum, B S; Chapman, A G

1999-01-01

Gabitril (tiagabine) is a potent selective inhibitor of the principal neuronal gamma-aminobutyric acid (GABA) transporter (GAT-1) in the cortex and hippocampus. By slowing the reuptake of synaptically-released GABA, it prolongs inhibitory postsynaptic potentials. In animal models of epilepsy, tiagabine is particularly effective against kindled (limbic) seizures and against reflexly-induced generalized convulsive seizures. These data are predictive of its efficacy in complex partial seizures in humans. Possible clinical applications outside the field of epilepsy include bipolar disorder and pain.

Single crystalline Ge(1-x)Mn(x) nanowires as building blocks for nanoelectronics.

PubMed

van der Meulen, Machteld I; Petkov, Nikolay; Morris, Michael A; Kazakova, Olga; Han, Xinhai; Wang, Kang L; Jacob, Ajey P; Holmes, Justin D

2009-01-01

Magnetically doped Si and Ge nanowires have potential application in future nanowire spin-based devices. Here, we report a supercritical fluid method for producing single crystalline Mn-doped Ge nanowires with a Mn-doping concentration of between 0.5-1.0 atomic % that display ferromagnetism above 300 K and a superior performance with respect to the hole mobility of around 340 cm(2)/Vs, demonstrating the potential of using these nanowires as building blocks for electronic devices.

Alkali Metal Rankine Cycle Boiler Technology Challenges and Some Potential Solutions for Space Nuclear Power and Propulsion Applications

NASA Technical Reports Server (NTRS)

Stone, James R.

1994-01-01

Alkali metal boilers are of interest for application to future space Rankine cycle power conversion systems. Significant progress on such boilers was accomplished in the 1960's and early 1970's, but development was not continued to operational systems since NASA's plans for future space missions were drastically curtailed in the early 1970's. In particular, piloted Mars missions were indefinitely deferred. With the announcement of the Space Exploration Initiative (SEI) in July 1989 by President Bush, interest was rekindled in challenging space missions and, consequently in space nuclear power and propulsion. Nuclear electric propulsion (NEP) and nuclear thermal propulsion (NTP) were proposed for interplanetary space vehicles, particularly for Mars missions. The potassium Rankine power conversion cycle became of interest to provide electric power for NEP vehicles and for 'dual-mode' NTP vehicles, where the same reactor could be used directly for propulsion and (with an additional coolant loop) for power. Although the boiler is not a major contributor to system mass, it is of critical importance because of its interaction with the rest of the power conversion system; it can cause problems for other components such as excess liquid droplets entering the turbine, thereby reducing its life, or more critically, it can drive instabilities-some severe enough to cause system failure. Funding for the SEI and its associated technology program from 1990 to 1993 was not sufficient to support significant new work on Rankine cycle boilers for space applications. In Fiscal Year 1994, funding for these challenging missions and technologies has again been curtailed, and planning for the future is very uncertain. The purpose of this paper is to review the technologies developed in the 1960's and 1970's in the light of the recent SEI applications. In this way, future Rankine cycle boiler programs may be conducted most efficiently. This report is aimed at evaluating alkali metal boiler technology for space Rankine cycle systems. Research is summarized on the problems of flow stability, liquid carryover, pressure drop and heat transfer, and on potential solutions developed, primarily those developed by the NASA Lewis Research Center in the 1960's and early 1970's.

The impact of health information technology and e-health on the future demand for physician services.

PubMed

Weiner, Jonathan P; Yeh, Susan; Blumenthal, David

2013-11-01

Arguably, few factors will change the future face of the American health care workforce as widely and dramatically as health information technology (IT) and electronic health (e-health) applications. We explore how such applications designed for providers and patients will affect the future demand for physicians. We performed what we believe to be the most comprehensive review of the literature to date, including previously published systematic reviews and relevant individual studies. We estimate that if health IT were fully implemented in 30 percent of community-based physicians' offices, the demand for physicians would be reduced by about 4-9 percent. Delegation of care to nurse practitioners and physician assistants supported by health IT could reduce the future demand for physicians by 4-7 percent. Similarly, IT-supported delegation from specialist physicians to generalists could reduce the demand for specialists by 2-5 percent. The use of health IT could also help address regional shortages of physicians by potentially enabling 12 percent of care to be delivered remotely or asynchronously. These estimated impacts could more than double if comprehensive health IT systems were adopted by 70 percent of US ambulatory care delivery settings. Future predictions of physician supply adequacy should take these likely changes into account.

[Cell therapy for Parkinson's disease: IV. Risks and future trends].

PubMed

Anisimov, S V

2009-01-01

Motor dysfunctions in Parkinson's disease are believed to be primarily due to the degeneration of dopaminergic neurons located in the substantia nigra pars compacta. Numerous cell replacement therapy approaches have been developed and tested, including these based on donor cell transplantation (embryonic and adult tissue-derived), adult mesenchymal stem cells (hMSCs)-, neural stem cells (hNSCs)- and finally human embryonic stem cells (hESCs)-based. Despite the progress achieved, numerous difficulties prevent wider practical application of stem cell-based therapy approaches for the treatment of Parkinson's disease. Among the latter, ethical, safety and technical issues stand out. Current series of reviews (Cell therapy for Parkinson's disease: I. Embryonic and adult donor tissue-based applications; II. Adult stem cell-based applications; III. Neonatal, fetal and embryonic stem cell-based applications; IV. Risks and future trends) aims providing a balanced and updated view on various issues associated with cell types (including stem cells) in regards to their potential in the treatment of Parkinson's disease. Essential features of the individual cell subtypes, principles of available cell handling protocols, transplantation, and safety issues are discussed extensively.

Assessment of Interval Data and Their Potential Application to Residential Electricity End-Use Modeling, An

EIA Publications

2015-01-01

The Energy Information Administration (EIA) is investigating the potential benefits of incorporating interval electricity data into its residential energy end use models. This includes interval smart meter and submeter data from utility assets and systems. It is expected that these data will play a significant role in informing residential energy efficiency policies in the future. Therefore, a long-term strategy for improving the RECS end-use models will not be complete without an investigation of the current state of affairs of submeter data, including their potential for use in the context of residential building energy modeling.

Complete genome sequence of Lactobacillus heilongjiangensis DSM 28069(T): Insight into its probiotic potential.

PubMed

Zheng, Beiwen; Jiang, Xiawei; Cheng, Hong; Xu, Zemin; Li, Ang; Hu, Xinjun; Xiao, Yonghong

2015-12-20

Lactobacillus heilongjiangensis DSM 28069(T) is a potential probiotic isolated from traditional Chinese pickle. Here we report the complete genome sequence of this strain. The complete genome is 2,790,548bp with the GC content of 37.5% and devoid of plasmids. Sets of genes involved in the biosynthesis of riboflavin and folate were identified in the genome, which revealed its potential application in biotechnological industry. The genome sequence of L. heilongjiangensis DSM 28069(T) now provides the fundamental information for future studies. Copyright © 2015 Elsevier B.V. All rights reserved.

Industrial applications of nanoparticles.

PubMed

Stark, W J; Stoessel, P R; Wohlleben, W; Hafner, A

2015-08-21

Research efforts in the past two decades have resulted in thousands of potential application areas for nanoparticles - which materials have become industrially relevant? Where are sustainable applications of nanoparticles replacing traditional processing and materials? This tutorial review starts with a brief analysis on what makes nanoparticles attractive to chemical product design. The article highlights established industrial applications of nanoparticles and then moves to rapidly emerging applications in the chemical industry and discusses future research directions. Contributions from large companies, academia and high-tech start-ups are used to elucidate where academic nanoparticle research has revolutionized industry practice. A nanomaterial-focused analysis discusses new trends, such as particles with an identity, and the influence of modern instrument advances in the development of novel industrial products.

Potential Application of Electronic Olfaction Systems in Feedstuffs Analysis and Animal Nutrition

PubMed Central

Campagnoli, Anna; Dell'Orto, Vittorio

2013-01-01

Electronic Olfaction Systems (EOSs) based on a variety of gas-sensing technologies have been developed to simulate in a simplified manner animal olfactory sensing systems. EOSs have been successfully applied to many applications and fields, including food technology and agriculture. Less information is available for EOS applications in the feed technology and animal nutrition sectors. Volatile Organic Compounds (VOCs), which are derived from both forages and concentrate ingredients of farm animal rations, are considered and described in this review as olfactory markers for feedstock quality and safety evaluation. EOS applications to detect VOCs from feedstuffs (as analytical matrices) are described, and some future scenarios are hypothesised. Furthermore, some EOS applications in animal feeding behaviour and organoleptic feed assessment are also described. PMID:24172280

Fly ashes from coal and petroleum coke combustion: current and innovative potential applications.

PubMed

González, Aixa; Navia, Rodrigo; Moreno, Natalia

2009-12-01

Coal fly ashes (CFA) are generated in large amounts worldwide. Current combustion technologies allow the burning of fuels with high sulfur content such as petroleum coke, generating non-CFA, such as petroleum coke fly ash (PCFA), mainly from fluidized bed combustion processes. The disposal of CFA and PCFA fly ashes can have severe impacts in the environment such as a potential groundwater contamination by the leaching of heavy metals and/or particulate matter emissions; making it necessary to treat or reuse them. At present CFA are utilized in several applications fields such as cement and concrete production, agriculture and soil stabilization. However, their reuse is restricted by the quality parameters of the end-product or requirements defined by the production process. Therefore, secondary material markets can use a limited amount of CFA, which implies the necessity of new markets for the unused CFA. Some potential future utilization options reviewed herein are zeolite synthesis and valuable metals extraction. In comparison to CFA, PCFA are characterized by a high Ca content, suggesting a possible use as neutralizers of acid wastewaters from mining operations, opening a new potential application area for PCFA that could solve contamination problems in emergent and mining countries such as Chile. However, this potential application may be limited by PCFA heavy metals leaching, mainly V and Ni, which are present in PCFA in high concentrations.

Strategies to support drug discovery through integration of systems and data.

PubMed

Waller, Chris L; Shah, Ajay; Nolte, Matthias

2007-08-01

Much progress has been made over the past several years to provide technologies for the integration of drug discovery software applications and the underlying data bits. Integration at the application layer has focused primarily on developing and delivering applications that support specific workflows within the drug discovery arena. A fine balance between creating behemoth applications and providing business value must be maintained. Heterogeneous data sources have typically been integrated at the data level in an effort to provide a more holistic view of the data packages supporting key decision points. This review will highlight past attempts, current status, and potential future directions for systems and data integration strategies in support of drug discovery efforts.

Sensors Applications, Volume 4, Sensors for Automotive Applications

NASA Astrophysics Data System (ADS)

Marek, Jiri; Trah, Hans-Peter; Suzuki, Yasutoshi; Yokomori, Iwao

2003-07-01

An international team of experts from the leading companies in this field gives a detailed picture of existing as well as future applications. They discuss in detail current technologies, design and construction concepts, market considerations and commercial developments. Topics covered include vehicle safety, fuel consumption, air conditioning, emergency control, traffic control systems, and electronic guidance using radar and video. Meeting the growing need for comprehensive information on the capabilities, potentials and limitations of modern sensor systems, Sensors Applications is a book series covering the use of sophisticated technologies and materials for the creation of advanced sensors and their implementation in the key areas process monitoring, building control, health care, automobiles, aerospace, environmental technology and household appliances.

Molecular Assembly of Polysaccharide-Based Microcapsules and Their Biomedical Applications.

PubMed

Feng, Xiyun; Du, Cuiling; Li, Junbai

2016-08-01

Advanced multifunctional microcapsules have revealed great potential in biomedical applications owing to their tunable size, shape, surface properties, and stimuli responsiveness. Polysaccharides are one of the most acceptable biomaterials for biomedical applications because of their outstanding virtues such as biocompatibility, biodegradability, and low toxicity. Many efforts have been devoted to investigating novel molecular design and efficient building blocks for polysaccharide-based microcapsules. In this Personal Account, we first summarize the common features of polysaccharides and the main principles of the design and fabrication of polysaccharide-based microcapsules, and further discuss their applications in biomedical areas and perspectives for future research. © 2016 The Chemical Society of Japan & Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

A Brief Review of the Need for Robust Smart Wireless Sensor Systems for Future Propulsion Systems, Distributed Engine Controls, and Propulsion Health Management

NASA Technical Reports Server (NTRS)

Hunter, Gary W.; Behbahani, Alireza

2012-01-01

Smart Sensor Systems with wireless capability operational in high temperature, harsh environments are a significant component in enabling future propulsion systems to meet a range of increasingly demanding requirements. These propulsion systems must incorporate technology that will monitor engine component conditions, analyze the incoming data, and modify operating parameters to optimize propulsion system operations. This paper discusses the motivation towards the development of high temperature, smart wireless sensor systems that include sensors, electronics, wireless communication, and power. The challenges associated with the use of traditional wired sensor systems will be reviewed and potential advantages of Smart Sensor Systems will be discussed. A brief review of potential applications for wireless smart sensor networks and their potential impact on propulsion system operation, with emphasis on Distributed Engine Control and Propulsion Health Management, will be given. A specific example related to the development of high temperature Smart Sensor Systems based on silicon carbide electronics will be discussed. It is concluded that the development of a range of robust smart wireless sensor systems are a foundation for future development of intelligent propulsion systems with enhanced capabilities.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Furey, M.J.; Kajdas, C.; Kaltenbach, K.W.

Advanced lubrication technologies based on the concept of tribopolymerization as a mechanism of boundary lubrication are described. Advantages of this approach as well as potential applications which could have an impact on the design, manufacture, and performance of existing and future automotive engines are presented and discussed. Tribopolymerization, a novel concept of molecular design developed by Furey and Kajdas, involves the continuous formation of thin polymeric films on rubbing surfaces; the protective films formed are self-replenishing. The antiwear compounds developed from this technology are effective with metals as well as ceramics and in the liquid as well as vapor phases.more » Furthermore, they are ashless and contain no harmful phosphorus or sulfur; and many are biodegradable. Thus, potential applications of this technology are diverse and include a variety of cost/performance/energy/environmental advantages. Examples include the following: (a) machining and cutting applications using thin films to reduce friction and ceramic tool wear; (b) the lubrication of ceramic engines (e.g., low heat rejection diesel engines) or ceramic components; (c) the development of ashless lubricants for existing and future automotive engines to reduce exhaust catalyst poisoning and environmental emissions; (d) ashless antiwear or ``lubricity`` additives for fuels, including gasoline, diesel and jet fuel; (e) vapor phase applications of this technology to high temperature gaseous systems or to fuel injector wear problems associated with the use of natural gas engines; and (f) the use of the concept of tribopolymerization as an enabling technology in the development of new engines and new automotive propulsion systems.« less

Uses and Applications of Climate Forecasts for Power Utilities.

NASA Astrophysics Data System (ADS)

Changnon, Stanley A.; Changnon, Joyce M.; Changnon, David

1995-05-01

The uses and potential applications of climate forecasts for electric and gas utilities were assessed 1) to discern needs for improving climate forecasts and guiding future research, and 2) to assist utilities in making wise use of forecasts. In-depth structured interviews were conducted with 56 decision makers in six utilities to assess existing and potential uses of climate forecasts. Only 3 of the 56 use forecasts. Eighty percent of those sampled envisioned applications of climate forecasts, given certain changes and additional information. Primary applications exist in power trading, load forecasting, fuel acquisition, and systems planning, with slight differences in interests between utilities. Utility staff understand probability-based forecasts but desire climatological information related to forecasted outcomes, including analogs similar to the forecasts, and explanations of the forecasts. Desired lead times vary from a week to three months, along with forecasts of up to four seasons ahead. The new NOAA forecasts initiated in 1995 provide the lead times and longer-term forecasts desired. Major hindrances to use of forecasts are hard-to-understand formats, lack of corporate acceptance, and lack of access to expertise. Recent changes in government regulations altered the utility industry, leading to a more competitive world wherein information about future weather conditions assumes much more value. Outreach efforts by government forecast agencies appear valuable to help achieve the appropriate and enhanced use of climate forecasts by the utility industry. An opportunity for service exists also for the private weather sector.

A systematic review of data mining and machine learning for air pollution epidemiology.

PubMed

Bellinger, Colin; Mohomed Jabbar, Mohomed Shazan; Zaïane, Osmar; Osornio-Vargas, Alvaro

2017-11-28

Data measuring airborne pollutants, public health and environmental factors are increasingly being stored and merged. These big datasets offer great potential, but also challenge traditional epidemiological methods. This has motivated the exploration of alternative methods to make predictions, find patterns and extract information. To this end, data mining and machine learning algorithms are increasingly being applied to air pollution epidemiology. We conducted a systematic literature review on the application of data mining and machine learning methods in air pollution epidemiology. We carried out our search process in PubMed, the MEDLINE database and Google Scholar. Research articles applying data mining and machine learning methods to air pollution epidemiology were queried and reviewed. Our search queries resulted in 400 research articles. Our fine-grained analysis employed our inclusion/exclusion criteria to reduce the results to 47 articles, which we separate into three primary areas of interest: 1) source apportionment; 2) forecasting/prediction of air pollution/quality or exposure; and 3) generating hypotheses. Early applications had a preference for artificial neural networks. In more recent work, decision trees, support vector machines, k-means clustering and the APRIORI algorithm have been widely applied. Our survey shows that the majority of the research has been conducted in Europe, China and the USA, and that data mining is becoming an increasingly common tool in environmental health. For potential new directions, we have identified that deep learning and geo-spacial pattern mining are two burgeoning areas of data mining that have good potential for future applications in air pollution epidemiology. We carried out a systematic review identifying the current trends, challenges and new directions to explore in the application of data mining methods to air pollution epidemiology. This work shows that data mining is increasingly being applied in air pollution epidemiology. The potential to support air pollution epidemiology continues to grow with advancements in data mining related to temporal and geo-spacial mining, and deep learning. This is further supported by new sensors and storage mediums that enable larger, better quality data. This suggests that many more fruitful applications can be expected in the future.

The Application of Nano-TiO2 Photo Semiconductors in Agriculture

NASA Astrophysics Data System (ADS)

Wang, Yan; Sun, Changjiao; Zhao, Xiang; Cui, Bo; Zeng, Zhanghua; Wang, Anqi; Liu, Guoqiang; Cui, Haixin

2016-11-01

Nanometer-sized titanium dioxide (TiO2) is an environmentally friendly optical semiconductor material. It has wide application value in many fields due to its excellent structural, optical, and chemical properties. The photocatalytic process of nano-TiO2 converts light energy into electrical or chemical energy under mild conditions. In recent years, the study and application of nano-TiO2 in the agricultural sector has gradually attracted attention. The nano-TiO2 applications of degrading pesticides, plant germination and growth, crop disease control, water purification, pesticide residue detection, etc. are good prospects. This review describes all of these applications and the research status and development, including the underlying principles, features, comprehensive applications, functional modification, and potential future directions, for TiO2 in agriculture.

[Health 4.0 - how are we doing tomorrow?

PubMed

Müschenich, Markus; Wamprecht, Laura

2018-03-01

Digitization in healthcare is progressing steadily. While currently processes are being optimized and processes are being facilitated, the breakthrough of digital medicine is still forthcoming. Digital medicine includes applications that focus on the patient and give them the promise of better care. Many digital health applications are raising attention in traditional healthcare, as they are increasingly showing evidence.This report discusses the question of the impact of digital health applications on healthcare in the near future by evaluating the effect of software used to improve diagnosis, therapy and the communication between patients and healthcare professionals.Three key technologies have been identified that have the potential to create applications that will have a major impact on healthcare. Exemplary applications in the fields of natural language processing, deep learning and virtual reality are presented and discussed, including how the widespread use of these products can change healthcare from the perspective of the patients.The prognosis for healthcare in a digital future is obviously: we are getting better. This is due to better quality in the field of diagnosis, enabling balance in the communication between patients and healthcare professionals, and low-threshold access to healthcare, regardless of location and time.

RFID Tag as a Sensor - A Review on the Innovative Designs and Applications

NASA Astrophysics Data System (ADS)

Meng, Zhaozong; Li, Zhen

2016-12-01

The Radio Frequency Identification (RFID) technology has gained interests in both academia and industry since its invention. In addition to the applications in access control and supply chain, RFID is also a cost-efficient solution for Non-Destructive Testing (NDT) and pervasive monitoring. The battery free RFID tags are used as independent electromagnetic sensors or energy harvesting and data transmission interface of sensor modules for different measurement purposes. This review paper aims to provide a comprehensive overview of the innovative designs and applications of RFID sensor technology with new insights, identify the technical challenges, and outline the future perspectives. With a brief introduction to the fundamentals of RFID measurement, the enabling technologies and recent technical progress are illustrated, followed by an extensive discussion of the novel designs and applications. Then, based on an in-depth analysis, the potential constraints are identified and the envisaged future directions are suggested, including printable/wearable RFID, System-on-Chip (SoC), ultra-low power, etc. The comprehensive discussion of RFID sensor technology will be inspirational and useful for academic and industrial communities in investigating, developing, and applying RFID for various measurement applications.

Future direction in marine bacterial agarases for industrial applications.

PubMed

Jahromi, Saeid Tamadoni; Barzkar, Noora

2018-06-16

The marine ecosystem has been known to be a rich source of novel enzymes. Agarase is a key enzyme that can hydrolyze agar in the marine environment. Marine bacterial agarase has been isolated from various sources, such as sediments, coastal water, and deep sea and from the surface of crustaceans and seaweeds. This review presents an account of the agarase production of marine bacteria. General information about agar, agarase, isolation, and purification of marine bacterial agarases; the biochemical properties of native agarase from marine bacteria; the biochemical properties of recombinant marine bacterial agarases from engineered microorganisms; and the industrial future of marine bacterial agarases is analyzed. With recent biotechnological processes, researchers need novel functional enzymes like agarase from marine resources, such as marine bacteria, that can be used for diverse applications in the biotechnological industry. Marine bacterial agarases might be of significant interest to the industry because they are safe and are a natural source. This review highlights the potential of marine bacteria as important sources of agarase for application in various industries.

Technical and Economical Demands on 25K - 77K Refrigerators for Future HTS — Series Products in Power Engineering

NASA Astrophysics Data System (ADS)

Gromoll, B.

2004-06-01

For the future high temperature superconductivity, HTS, series products new refrigerators are essential. Demands are made on these which are only partly fulfilled by refrigerators available in the market today. This refers to cooling power, initial cost and in particular reliability. Without proper refrigeration techniques it will be almost impossible to bring HTS products to the market. Based on the experiences made by the construction and operation of HTS prototypes within our company, like the 400 kW motor, 1.2 MVA current limiter and 1 MVA traction-transformer provided with refrigerators which are available in the market today, criteria have been established to identify the future technical and economical requirements. These criteria apply to efficiency, maintainability, operation flexibility, feasibility of integration and performance/cost ratio. For the temperature range of 20 K to 77 K cooling with Gifford-McMahon, Pulse Tube, Stirling and Mixture-Cascade refrigerators are applicable. The development potential of these processes are compared for the different applications in future series products. Presented are the necessary steps towards reliable and economic refrigerators from the viewpoint of an equipment manufacturer. These are essential for a market entry in the year 2008.

Potential and problems in ultrasound-responsive drug delivery systems

PubMed Central

Zhao, Ying-Zheng; Du, Li-Na; Lu, Cui-Tao; Jin, Yi-Guang; Ge, Shu-Ping

2013-01-01

Ultrasound is an important local stimulus for triggering drug release at the target tissue. Ultrasound-responsive drug delivery systems (URDDS) have become an important research focus in targeted therapy. URDDS include many different formulations, such as microbubbles, nanobubbles, nanodroplets, liposomes, emulsions, and micelles. Drugs that can be loaded into URDDS include small molecules, biomacromolecules, and inorganic substances. Fields of clinical application include anticancer therapy, treatment of ischemic myocardium, induction of an immune response, cartilage tissue engineering, transdermal drug delivery, treatment of Huntington’s disease, thrombolysis, and disruption of the blood–brain barrier. This review focuses on recent advances in URDDS, and discusses their formulations, clinical application, and problems, as well as a perspective on their potential use in the future. PMID:23637531

Block copolymer nanoassemblies for photodynamic therapy and diagnosis.

PubMed

Dickerson, Matthew; Bae, Younsoo

2013-11-01

Light can be a powerful therapeutic and diagnostic tool. Light-sensitive molecules can be used to develop locally targeted cancer therapeutics. This approach is known as photodynamic therapy (PDT). Similarly, it is possible to diagnose diseases and track the course of treatment in vivo using ligh-sensitive molecules. This methodology is referred to as photodynamic diagnosis (PDD). Despite the potential, many PDT and PDD agents have imperfect physiochemical properties for their successful clinical application. Nanotechnology may solve these issues by improving the viability of PDT and PDD. This review summarizes the current state of PDT and PDD development, the integration of nanotechnology in the field, and the prospective future applications, demonstrating the potential of PDT and PDD for improved cancer treatment and diagnosis.

Transient Micromotors That Disappear When No Longer Needed.

PubMed

Chen, Chuanrui; Karshalev, Emil; Li, Jinxing; Soto, Fernando; Castillo, Roxanne; Campos, Isaac; Mou, Fangzhi; Guan, Jianguo; Wang, Joseph

2016-11-22

Transient self-destroyed micromotors that autonomously disappear in biological media at controlled rates upon completing their task, without leaving a toxic residue, are presented. The propulsion and degradation characteristics of the self-destroyed Mg/ZnO, Mg/Si, and Zn/Fe Janus micromotors and single-component Zn micromotors are described. The degradation of the Janus micromotors relies on the different corrosion rates of their core-shell components. Inductively coupled plasma optical emission spectrometry measurements are used to probe the time-dependent degradation of the different constituents of the micromotors. The toxicity of the transient micromotors is discussed toward their potential use in biomedical applications. This concept of transient micromotors offers considerable potential for diverse practical applications in the near future.

Application of CFD codes to the design and development of propulsion systems

NASA Technical Reports Server (NTRS)

Lord, W. K.; Pickett, G. F.; Sturgess, G. J.; Weingold, H. D.

1987-01-01

The internal flows of aerospace propulsion engines have certain common features that are amenable to analysis through Computational Fluid Dynamics (CFD) computer codes. Although the application of CFD to engineering problems in engines was delayed by the complexities associated with internal flows, many codes with different capabilities are now being used as routine design tools. This is illustrated by examples taken from the aircraft gas turbine engine of flows calculated with potential flow, Euler flow, parabolized Navier-Stokes, and Navier-Stokes codes. Likely future directions of CFD applied to engine flows are described, and current barriers to continued progress are highlighted. The potential importance of the Numerical Aerodynamic Simulator (NAS) to resolution of these difficulties is suggested.

Applications of Brain–Machine Interface Systems in Stroke Recovery and Rehabilitation

PubMed Central

Francisco, Gerard E.; Contreras-Vidal, Jose L.

2014-01-01

Stroke is a leading cause of disability, significantly impacting the quality of life (QOL) in survivors, and rehabilitation remains the mainstay of treatment in these patients. Recent engineering and technological advances such as brain-machine interfaces (BMI) and robotic rehabilitative devices are promising to enhance stroke neu-rorehabilitation, to accelerate functional recovery and improve QOL. This review discusses the recent applications of BMI and robotic-assisted rehabilitation in stroke patients. We present the framework for integrated BMI and robotic-assisted therapies, and discuss their potential therapeutic, assistive and diagnostic functions in stroke rehabilitation. Finally, we conclude with an outlook on the potential challenges and future directions of these neurotechnologies, and their impact on clinical rehabilitation. PMID:25110624

Universal bounds on the time evolution of entanglement entropy.

PubMed

Avery, Steven G; Paulos, Miguel F

2014-12-05

Using relative entropy, we derive bounds on the time rate of change of geometric entanglement entropy for any relativistic quantum field theory in any dimension. The bounds apply to both mixed and pure states, and may be extended to curved space. We illustrate the bounds in a few examples and comment on potential applications and future extensions.

Bioconjugated gold nanoparticles accelerate the growth of new blood vessels through redox signaling.

PubMed

Nethi, Susheel Kumar; Mukherjee, Sudip; Veeriah, Vimal; Barui, Ayan Kumar; Chatterjee, Suvro; Patra, Chitta Ranjan

2014-11-28

We have designed and developed novel pro-angiogenic bio-synthesized gold nanoconjugates (b-Au-HP) that make new blood vessels, as observed by several in vitro and in vivo assays, suggesting their future potential applications in alternative treatment strategies for wound healing, cardiovascular diseases (CVD) and ischemic diseases using a nanomedicine approach.

Study of the Effectiveness of OCR for Decentralized Data Capture and Conversion. Final Report.

ERIC Educational Resources Information Center

Liston, David M.; And Others

The ERIC network conversion to an OCR (Optical Character Recognition) mode of data entry was studied to analyze the potential effectiveness of OCR data entry for future EPC/s (Editorial Processing Centers). Study results are also applicable to any other system involving decentralized bibliographic data capture and conversion functions. The report…

The Coevolution of Society and Multimedia Technology: Issues in Predicting the Future Innovation and Use of a Ubiquitous Technology.

ERIC Educational Resources Information Center

Stewart, James; Williams, Robin

1998-01-01

Criticizes "technologically deterministic" approaches, which seek to extrapolate social change from technological potential. Shows how a three-layer model of component, system, and application technologies can be used to integrate findings from the use and development of technology in specific sectors. Examines three cases of…

Finding Students Who Are Wise, Practical, and Creative

ERIC Educational Resources Information Center

Sternberg, Robert J.

2007-01-01

One purpose of a college education is to create active and engaged citizens and future leaders. If everyone wants students who have the potential to become such people, it is necessary to keep in mind the skills involved in good citizenship and positive leadership when evaluating applicants. Many of the leaders who have gotten the world into its…

76 FR 74067 - Medicare Program; Announcement of a New Application Deadline for the Advance Payment Model

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-30

.... One potential mechanism for achieving this goal is for CMS to partner with groups of health care... will test whether and how pre-paying a portion of future shared savings could increase participation in... Accountable Care Organization (ACO) through which they work together to coordinate care for a specified group...

Anion transport and supramolecular medicinal chemistry

DOE PAGES

Gale, Philip A.; Davis, Jeffery T.; Quesada, Roberto

2017-04-05

New approaches to the transmembrane transport of anions are discussed in this review. Advances in the design of small molecule anion carriers are reviewed in addition to advances in the design of synthetic anion channels. The application of anion transporters to the potential future treatment of disease is discussed in the context of recent findings on the selectivity of anion transporters.

Anion transport and supramolecular medicinal chemistry

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gale, Philip A.; Davis, Jeffery T.; Quesada, Roberto

New approaches to the transmembrane transport of anions are discussed in this review. Advances in the design of small molecule anion carriers are reviewed in addition to advances in the design of synthetic anion channels. The application of anion transporters to the potential future treatment of disease is discussed in the context of recent findings on the selectivity of anion transporters.

Application of the Localisation Platform Crowdin in Translator Education

ERIC Educational Resources Information Center

Kudla, Dominik

2017-01-01

This article is an attempt to briefly describe the potential of the online localisation platform Crowdin for the education of the future translators at universities and in private courses or workshops. This description is provided on the basis of the information gathered through the user experience of the author and uses the example of the Khan…

The regulation of mobile medical applications.

PubMed

Yetisen, Ali Kemal; Martinez-Hurtado, J L; da Cruz Vasconcellos, Fernando; Simsekler, M C Emre; Akram, Muhammad Safwan; Lowe, Christopher R

2014-03-07

The rapidly expanding number of mobile medical applications have the potential to transform the patient-healthcare provider relationship by improving the turnaround time and reducing costs. In September 2013, the U.S. Food and Drug Administration (FDA) issued guidance to regulate these applications and protect consumers by minimising the risks associated with their unintended use. This guidance distinguishes between the subset of mobile medical apps which may be subject to regulation and those that are not. The marketing claims of the application determine the intent. Areas of concern include compliance with regular updates of the operating systems and of the mobile medical apps themselves. In this article, we explain the essence of this FDA guidance by providing examples and evaluating the impact on academia, industry and other key stakeholders, such as patients and clinicians. Our assessment indicates that awareness and incorporation of the guidelines into product development can hasten the commercialisation and market entry process. Furthermore, potential obstacles have been discussed and directions for future development suggested.

Impact of Saw Dust Application on the Distribution of Potentially Toxic Metals in Contaminated Soil.

PubMed

Awokunmi, Emmmanuel E

2017-12-01

The need to develop an approach for the reclamation of contaminated site using locally available agricultural waste has been considered. The present study investigated the application of sawdust as an effective amendment in the immobilization of potentially toxic metals (PTMs) by conducting a greenhouse experiment on soil collected from an automobile dumpsite. The amended and non-amended soil samples were analyzed for their physicochemical parameters and sequential extraction of PTMs. The results revealed that application of amendment had positive impact on the physicochemical parameters as organic matter content and cation exchange capacity increased from 12.1% to 12.8% and 16.4 to 16.8 meq/100 g respectively. However, the mobility and bioavalability of these metals was reduced as they were found to be distributed mostly in the non-exchangeable phase of soil. Therefore, application of sawdust successfully immobilized PTMs and could be applied for future studies in agricultural soil reclamation.

Immobilized liquid layers: A new approach to anti-adhesion surfaces for medical applications

PubMed Central

Sotiri, Irini; Overton, Jonathan C; Waterhouse, Anna

2016-01-01

Surface fouling and undesired adhesion are nearly ubiquitous problems in the medical field, complicating everything from surgeries to routine daily care of patients. Recently, the concept of immobilized liquid (IL) interfaces has been gaining attention as a highly versatile new approach to antifouling, with a wide variety of promising applications in medicine. Here, we review the general concepts behind IL layers and discuss the fabrication strategies on medically relevant materials developed so far. We also summarize the most important findings to date on applications of potential interest to the medical community, including the use of these surfaces as anti-thrombogenic and anti-bacterial materials, anti-adhesive textiles, high-performance coatings for optics, and as unique platforms for diagnostics. Although the full potential and pitfalls of IL layers in medicine are just beginning to be explored, we believe that this approach to anti-adhesive surfaces will prove broadly useful for medical applications in the future. PMID:27022136

Principles and applications of Raman spectroscopy in pharmaceutical drug discovery and development.

PubMed

Gala, Urvi; Chauhan, Harsh

2015-02-01

In recent years, Raman spectroscopy has become increasingly important as an analytical technique in various scientific areas of research and development. This is partly due to the technological advancements in Raman instrumentation and partly due to detailed fingerprinting that can be derived from Raman spectra. Its versatility of applications, rapidness of collection and easy analysis have made Raman spectroscopy an attractive analytical tool. The following review describes Raman spectroscopy and its application within the pharmaceutical industry. The authors explain the theory of Raman scattering and its variations in Raman spectroscopy. The authors also highlight how Raman spectra are interpreted, providing examples. Raman spectroscopy has a number of potential applications within drug discovery and development. It can be used to estimate the molecular activity of drugs and to establish a drug's physicochemical properties such as its partition coefficient. It can also be used in compatibility studies during the drug formulation process. Raman spectroscopy's immense potential should be further investigated in future.

Application of laminar flow control to high-bypass-ratio turbofan engine nacelles

NASA Technical Reports Server (NTRS)

Wie, Y. S.; Collier, F. S., Jr.; Wagner, R. D.

1991-01-01

Recently, the concept of the application of hybrid laminar flow to modern commercial transport aircraft was successfully flight tested on a Boeing 757 aircraft. In this limited demonstration, in which only part of the upper surface of the swept wing was designed for the attainment of laminar flow, significant local drag reduction was measured. This paper addresses the potential application of this technology to laminarize the external surface of large, modern turbofan engine nacelles which may comprise as much as 5-10 percent of the total wetted area of future commercial transports. A hybrid-laminar-flow-control (HLFC) pressure distribution is specified and the corresponding nacelle geometry is computed utilizing a predictor/corrector design method. Linear stability calculations are conducted to provide predictions of the extent of the laminar boundary layer. Performance studies are presented to determine potential benefits in terms of reduced fuel consumption.

Emerging Applications of Porphryins in Photomedicine

NASA Astrophysics Data System (ADS)

Huang, Haoyuan; Song, Wentao; Rieffel, James; Lovell, Jonathan

2015-04-01

Biomedical applications of porphyrins and related molecules have been extensively pursued in the context of photodynamic therapy (PDT). Recent advances in nanoscale engineering have opened the door for new ways that porphyrins stand to potentially benefit human health. Metalloporphyrins are inherently suitable for many types of medical imaging and therapy. Traditional nanocarriers such as liposomes, dendrimers and silica nanoparticles have been explored for photosensitizer delivery. Concurrently, entirely new classes of porphyrin nanostructures are being developed, such as smart materials that are activated by specific biochemicals encountered at disease sites. Techniques have been developed that improve treatments by combining biomaterials with photosensitizers and functional moieties such as peptides, DNA and antibodies. Compared to simpler structures, these more complex and functional designs can potentially decrease side effects and lead to safer and more efficient phototherapies. This review examines recent research on porphyrin-derived materials in multimodal imaging, drug delivery, bio-sensing, phototherapy and probe design, demonstrating their bright future for biomedical applications.

Progress in space nuclear reactor power systems technology development - The SP-100 program

NASA Technical Reports Server (NTRS)

Davis, H. S.

1984-01-01

Activities related to the development of high-temperature compact nuclear reactors for space applications had reached a comparatively high level in the U.S. during the mid-1950s and 1960s, although only one U.S. nuclear reactor-powered spacecraft was actually launched. After 1973, very little effort was devoted to space nuclear reactor and propulsion systems. In February 1983, significant activities toward the development of the technology for space nuclear reactor power systems were resumed with the SP-100 Program. Specific SP-100 Program objectives are partly related to the determination of the potential performance limits for space nuclear power systems in 100-kWe and 1- to 100-MW electrical classes. Attention is given to potential missions and applications, regimes of possible space power applicability, safety considerations, conceptual system designs, the establishment of technical feasibility, nuclear technology, materials technology, and prospects for the future.

The NASA In-Space Propulsion Technology Project's Current Products and Future Directions

NASA Technical Reports Server (NTRS)

Anderson, David J.; Dankanich, John; Munk, Michelle M.; Pencil, Eric; Liou, Larry

2010-01-01

Since its inception in 2001, the objective of the In-Space Propulsion Technology (ISPT) project has been developing and delivering in-space propulsion technologies that enable or enhance NASA robotic science missions. These in-space propulsion technologies are applicable, and potentially enabling for future NASA flagship and sample return missions currently under consideration, as well as having broad applicability to future Discovery and New Frontiers mission solicitations. This paper provides status of the technology development, applicability, and availability of in-space propulsion technologies that recently completed, or will be completing within the next year, their technology development and are ready for infusion into missions. The paper also describes the ISPT project s future focus on propulsion for sample return missions. The ISPT technologies completing their development are: 1) the high-temperature Advanced Material Bipropellant Rocket (AMBR) engine providing higher performance for lower cost; 2) NASA s Evolutionary Xenon Thruster (NEXT) ion propulsion system, a 0.6-7 kW throttle-able gridded ion system; and 3) aerocapture technologies which include thermal protection system (TPS) materials and structures, guidance, navigation, and control (GN&C) models of blunt-body rigid aeroshells; and atmospheric and aerothermal effect models. The future technology development areas for ISPT are: 1) Planetary Ascent Vehicles (PAV); 2) multi-mission technologies for Earth Entry Vehicles (MMEEV) needed for sample return missions from many different destinations; 3) propulsion for Earth Return Vehicles (ERV) and transfer stages, and electric propulsion for sample return and low cost missions; 4) advanced propulsion technologies for sample return; and 5) Systems/Mission Analysis focused on sample return propulsion.

The Boom in 3D-Printed Sensor Technology

PubMed Central

Xu, Yuanyuan; Wu, Xiaoyue; Guo, Xiao; Kong, Bin; Zhang, Min; Qian, Xiang; Mi, Shengli; Sun, Wei

2017-01-01

Future sensing applications will include high-performance features, such as toxin detection, real-time monitoring of physiological events, advanced diagnostics, and connected feedback. However, such multi-functional sensors require advancements in sensitivity, specificity, and throughput with the simultaneous delivery of multiple detection in a short time. Recent advances in 3D printing and electronics have brought us closer to sensors with multiplex advantages, and additive manufacturing approaches offer a new scope for sensor fabrication. To this end, we review the recent advances in 3D-printed cutting-edge sensors. These achievements demonstrate the successful application of 3D-printing technology in sensor fabrication, and the selected studies deeply explore the potential for creating sensors with higher performance. Further development of multi-process 3D printing is expected to expand future sensor utility and availability. PMID:28534832

An overview of computer-based natural language processing

NASA Technical Reports Server (NTRS)

Gevarter, W. B.

1983-01-01

Computer based Natural Language Processing (NLP) is the key to enabling humans and their computer based creations to interact with machines in natural language (like English, Japanese, German, etc., in contrast to formal computer languages). The doors that such an achievement can open have made this a major research area in Artificial Intelligence and Computational Linguistics. Commercial natural language interfaces to computers have recently entered the market and future looks bright for other applications as well. This report reviews the basic approaches to such systems, the techniques utilized, applications, the state of the art of the technology, issues and research requirements, the major participants and finally, future trends and expectations. It is anticipated that this report will prove useful to engineering and research managers, potential users, and others who will be affected by this field as it unfolds.

Recent advances in bioprinting techniques: approaches, applications and future prospects.

PubMed

Li, Jipeng; Chen, Mingjiao; Fan, Xianqun; Zhou, Huifang

2016-09-20

Bioprinting technology shows potential in tissue engineering for the fabrication of scaffolds, cells, tissues and organs reproducibly and with high accuracy. Bioprinting technologies are mainly divided into three categories, inkjet-based bioprinting, pressure-assisted bioprinting and laser-assisted bioprinting, based on their underlying printing principles. These various printing technologies have their advantages and limitations. Bioprinting utilizes biomaterials, cells or cell factors as a "bioink" to fabricate prospective tissue structures. Biomaterial parameters such as biocompatibility, cell viability and the cellular microenvironment strongly influence the printed product. Various printing technologies have been investigated, and great progress has been made in printing various types of tissue, including vasculature, heart, bone, cartilage, skin and liver. This review introduces basic principles and key aspects of some frequently used printing technologies. We focus on recent advances in three-dimensional printing applications, current challenges and future directions.

Future Mission Trends and their Implications for the Deep Space Network

NASA Technical Reports Server (NTRS)

Abraham, Douglas S.

2006-01-01

Planning for the upgrade and/or replacement of Deep Space Network (DSN) assets that typically operate for forty or more years necessitates understanding potential customer needs as far into the future as possible. This paper describes the methodology Deep Space Network (DSN) planners use to develop this understanding, some key future mission trends that have emerged from application of this methodology, and the implications of the trends for the DSN's future evolution. For NASA's current plans out to 2030, these trends suggest the need to accommodate: three times as many communication links, downlink rates two orders of magnitude greater than today's, uplink rates some four orders of magnitude greater, and end-to-end link difficulties two-to-three orders of magnitude greater. To meet these challenges, both DSN capacity and capability will need to increase.

Advances in Electronic-Nose Technologies Developed for Biomedical Applications

PubMed Central

Wilson, Alphus D.; Baietto, Manuela

2011-01-01

The research and development of new electronic-nose applications in the biomedical field has accelerated at a phenomenal rate over the past 25 years. Many innovative e-nose technologies have provided solutions and applications to a wide variety of complex biomedical and healthcare problems. The purposes of this review are to present a comprehensive analysis of past and recent biomedical research findings and developments of electronic-nose sensor technologies, and to identify current and future potential e-nose applications that will continue to advance the effectiveness and efficiency of biomedical treatments and healthcare services for many years. An abundance of electronic-nose applications has been developed for a variety of healthcare sectors including diagnostics, immunology, pathology, patient recovery, pharmacology, physical therapy, physiology, preventative medicine, remote healthcare, and wound and graft healing. Specific biomedical e-nose applications range from uses in biochemical testing, blood-compatibility evaluations, disease diagnoses, and drug delivery to monitoring of metabolic levels, organ dysfunctions, and patient conditions through telemedicine. This paper summarizes the major electronic-nose technologies developed for healthcare and biomedical applications since the late 1980s when electronic aroma detection technologies were first recognized to be potentially useful in providing effective solutions to problems in the healthcare industry. PMID:22346620

Metabolomics: available results, current research projects in breast cancer, and future applications.

PubMed

Claudino, Wederson Marcos; Quattrone, Alessandro; Biganzoli, Laura; Pestrin, Marta; Bertini, Ivano; Di Leo, Angelo

2007-07-01

Metabolomics is the newest "omics" science. It is a dynamic portrait of the metabolic status of living systems. Metabolomics has brought new insights on metabolic fluxes and a more comprehensive and holistic understanding of a cell's environment. This burgeoning field promises to be a potential tool to fill the gap between genotype and phenotype. As its preceding "omics" sciences (ie, genomics and proteomics), metabolomics' aim is to dredge information hidden in a sea of data. This technology permits simultaneous monitoring of many hundreds, or thousands, of macro- and small molecules, as well as functional monitoring of multiple pivotal cellular pathways. In addition, elucidation of cellular responses to molecular damage, including evolutionarily conserved inducible molecular defense systems, could be achieved with metabolomics and could lead to the discovery of new biomarkers of molecular responses to functional perturbations. If metabolomic information could be translated into diagnostic tests, it might have the potential to impact on clinical practice, and it might lead to the supplementation of traditional biomarkers of cellular integrity, cell and tissue homeostasis, and morphological alterations that result from cell damage or death. In this review the concept and characteristics of metabolomics are introduced. Main current applications of metabolomics in cancer research are reviewed, including its potential in the drug discovery field, and, last but not least, its potential impact in the field of monitoring response and toxicity to anticancer agents. In the last section, research projects ongoing at our institution and future challenges for metabolomics will be presented and briefly discussed.

Interactive educational simulators in diabetes care.

PubMed

Lehmann, E D

1997-01-01

Since the Diabetes Control and Complications Trial demonstrated the substantial benefits of tight glycaemic control there has been renewed interest in the application of information technology (IT) based techniques for improving the day-to-day care of patients with diabetes mellitus. Computer-based educational approaches have a great deal of potential for patients use, and may offer a means of training more health-care professionals to deliver such improved care. In this article the potential role of IT in diabetes education is reviewed, focusing in particular on the application of compartmental models in both computer-based interactive simulators and educational video games. Close attention is devoted to practical applications-available today-for use by patients, their relatives, students and health-care professionals. The novel features and potential benefits of such methodologies are highlighted and some of the limitations of currently available software are discussed. The need for improved graphical user interfaces, and for further efforts to evaluate such programs and demonstrate an educational benefit from their use are identified as hurdles to their more widespread application. The review concludes with a look to the future and the type of modelling features which should be provided in the next generation of interactive diabetes simulators and educational video games.

Bright Side of Lignin Depolymerization: Toward New Platform Chemicals

PubMed Central

2018-01-01

Lignin, a major component of lignocellulose, is the largest source of aromatic building blocks on the planet and harbors great potential to serve as starting material for the production of biobased products. Despite the initial challenges associated with the robust and irregular structure of lignin, the valorization of this intriguing aromatic biopolymer has come a long way: recently, many creative strategies emerged that deliver defined products via catalytic or biocatalytic depolymerization in good yields. The purpose of this review is to provide insight into these novel approaches and the potential application of such emerging new structures for the synthesis of biobased polymers or pharmacologically active molecules. Existing strategies for functionalization or defunctionalization of lignin-based compounds are also summarized. Following the whole value chain from raw lignocellulose through depolymerization to application whenever possible, specific lignin-based compounds emerge that could be in the future considered as potential lignin-derived platform chemicals. PMID:29337543

Thermophotovoltaic power conversion systems: Current performance and future potential

DOE PAGES

Celanovic, Ivan; Bermel, Peter; Soljacic, Marin

2011-01-01

Thermophotovoltaic (TPV) systems offer a unique, solid-state approach to converting heat into electricity based on thermal radiation. TPV is particularly suitable for certain classes of power generation applications that are not well served by standard engines, such as long, remote missions where repairs are difficult, and portable generation where space and weight are at a premium. While standard thermophotovoltaics are limited in their conversion efficiency, photonic crystals can improve performance by an order of magnitude for a number of systems. While there are many potential applications, two exemplary systems are discussed: TPV μreactors for portable power generation in a mm-scalemore » form factor, and solar TPV for long-term off-grid power generation from sunlight. In both cases, photonic crystals can enable potential performance exceeding that of many other well-known technologies, such as single-junction photovoltaics.« less

Biosensoric potential of microbial fuel cells.

PubMed

Schneider, György; Kovács, Tamás; Rákhely, Gábor; Czeller, Miklós

2016-08-01

Recent progress in microbial fuel cell (MFC) technology has highlighted the potential of these devices to be used as biosensors. The advantages of MFC-based biosensors are that they are phenotypic and can function in either assay- or flow-through formats. These features make them appropriate for contiguous on-line monitoring in laboratories and for in-field applications. The selectivity of an MFC biosensor depends on the applied microorganisms in the anodic compartment where electron transfer (ET) between the artificial surface (anode) and bacterium occurs. This process strongly determines the internal resistance of the sensoric system and thus influences signal outcome and response time. Despite their beneficial characteristics, the number of MFC-based biosensoric applications has been limited until now. The aim of this mini-review is to turn attention to the biosensoric potential of MFCs by summarizing ET mechanisms on which recently established and future sensoric devices are based.

Deep Space Mission Applications for NEXT: NASA's Evolutionary Xenon Thruster

NASA Technical Reports Server (NTRS)

Oh, David; Benson, Scott; Witzberger, Kevin; Cupples, Michael

2004-01-01

NASA's Evolutionary Xenon Thruster (NEXT) is designed to address a need for advanced ion propulsion systems on certain future NASA deep space missions. This paper surveys seven potential missions that have been identified as being able to take advantage of the unique capabilities of NEXT. Two conceptual missions to Titan and Neptune are analyzed, and it is shown that ion thrusters could decrease launch mass and shorten trip time, to Titan compared to chemical propulsion. A potential Mars Sample return mission is described, and compassion made between a chemical mission and a NEXT based mission. Four possible near term applications to New Frontiers and Discovery class missions are described, and comparisons are made to chemical systems or existing NSTAR ion propulsion system performance. The results show that NEXT has potential performance and cost benefits for missions in the Discovery, New Frontiers, and larger mission classes.

Impact of Climate Change on Soil and Groundwater Chemistry Subject to Process Waste Land Application

NASA Astrophysics Data System (ADS)

McNab, W. W.

2013-12-01

Nonhazardous aqueous process waste streams from food and beverage industry operations are often discharged via managed land application in a manner designed to minimize impacts to underlying groundwater. Process waste streams are typically characterized by elevated concentrations of solutes such as ammonium, organic nitrogen, potassium, sodium, and organic acids. Land application involves the mixing of process waste streams with irrigation water which is subsequently applied to crops. The combination of evapotranspiration and crop salt uptake reduces the downward mass fluxes of percolation water and salts. By carefully managing application schedules in the context of annual climatological cycles, growing seasons, and process requirements, potential adverse environmental impacts to groundwater can be mitigated. However, climate change poses challenges to future process waste land application efforts because the key factors that determine loading rates - temperature, evapotranspiration, seasonal changes in the quality and quantity of applied water, and various crop factors - are all likely to deviate from current averages. To assess the potential impact of future climate change on the practice of land application, coupled process modeling entailing transient unsaturated fluid flow, evapotranspiration, crop salt uptake, and multispecies reactive chemical transport was used to predict changes in salt loading if current practices are maintained in a warmer, drier setting. As a first step, a coupled process model (Hydrus-1D, combined with PHREEQC) was calibrated to existing data sets which summarize land application loading rates, soil water chemistry, and crop salt uptake for land disposal of process wastes from a food industry facility in the northern San Joaquin Valley of California. Model results quantify, for example, the impacts of evapotranspiration on both fluid flow and soil water chemistry at shallow depths, with secondary effects including carbonate mineral precipitation and ion exchange. The calibrated model was then re-run assuming different evapotranspiration and crop growth regimes, and different seasonally-adjusted applied water compositions, to elucidate possible impacts to salt loading reactive chemistry. The results of the predictive modeling indicate the extent to which salts could be redistributed within the soil column as a consequence of climate change. The degree to which these findings are applicable to process waste land application operations at other sites was explored by varying the soil unsaturated flow parameters as a model sensitivity assessment. Taken together, the model results help to quantify operational changes to land application that may be necessary to avoid future adverse environmental impacts to soil and groundwater.

Metallic ions as therapeutic agents in tissue engineering scaffolds: an overview of their biological applications and strategies for new developments

PubMed Central

Mouriño, Viviana; Cattalini, Juan Pablo; Boccaccini, Aldo R.

2012-01-01

This article provides an overview on the application of metallic ions in the fields of regenerative medicine and tissue engineering, focusing on their therapeutic applications and the need to design strategies for controlling the release of loaded ions from biomaterial scaffolds. A detailed summary of relevant metallic ions with potential use in tissue engineering approaches is presented. Remaining challenges in the field and directions for future research efforts with focus on the key variables needed to be taken into account when considering the controlled release of metallic ions in tissue engineering therapeutics are also highlighted. PMID:22158843

PET and MR imaging: the odd couple or a match made in heaven?

PubMed

Catana, Ciprian; Guimaraes, Alexander R; Rosen, Bruce R

2013-05-01

PET and MR imaging are modalities routinely used for clinical and research applications. Integrated scanners capable of acquiring PET and MR imaging data in the same session, sequentially or simultaneously, have recently become available for human use. In this article, we describe some of the technical advances that allowed the development of human PET/MR scanners; briefly discuss methodologic challenges and opportunities provided by this novel technology; and present potential oncologic, cardiac, and neuropsychiatric applications. These examples range from studies that might immediately benefit from PET/MR to more advanced applications on which future development might have an even broader impact.

Easy access to heterobimetallic complexes for medical imaging applications via microwave-enhanced cycloaddition.

PubMed

Desbois, Nicolas; Pacquelet, Sandrine; Dubois, Adrien; Michelin, Clément; Gros, Claude P

2015-01-01

The Cu(I)-catalysed Huisgen cycloaddition, known as "click" reaction, has been applied to the synthesis of a range of triazole-linked porphyrin/corrole to DOTA/NOTA derivatives. Microwave irradiation significantly accelerates the reaction. The synthesis of heterobimetallic complexes was easily achieved in up to 60% isolated yield. Heterobimetallic complexes were easily prepared as potential MRI/PET (SPECT) bimodal contrast agents incorporating one metal (Mn, Gd) for the enhancement of contrast for MRI applications and one "cold" metal (Cu, Ga, In) for future radionuclear imaging applications. Preliminary relaxivity measurements showed that the reported complexes are promising contrast agents (CA) in MRI.

Lanthanide-doped upconverting phosphors for bioassay and therapy

NASA Astrophysics Data System (ADS)

Guo, Huichen; Sun, Shiqi

2012-10-01

Lanthanide-doped fluorescent materials have gained increasing attention in recent years due to their unique luminescence properties which have led to their use in wide-ranging fields including those of biological applications. Aside from being used as agents for in vivo imaging, lanthanide-doped fluorescent materials also present many advantages for use in bioassays and therapy. In this review, we summarize the applications of lanthanide-doped up-converting phosphors (UCPs) in protein and gene detection, as well as in photodynamic and gene therapy in recent years, and outline their future potential in biological applications. The current report could serve as a reference for researchers in relevant fields.

Easy access to heterobimetallic complexes for medical imaging applications via microwave-enhanced cycloaddition

PubMed Central

Desbois, Nicolas; Pacquelet, Sandrine; Dubois, Adrien; Michelin, Clément

2015-01-01

Summary The Cu(I)-catalysed Huisgen cycloaddition, known as “click” reaction, has been applied to the synthesis of a range of triazole-linked porphyrin/corrole to DOTA/NOTA derivatives. Microwave irradiation significantly accelerates the reaction. The synthesis of heterobimetallic complexes was easily achieved in up to 60% isolated yield. Heterobimetallic complexes were easily prepared as potential MRI/PET (SPECT) bimodal contrast agents incorporating one metal (Mn, Gd) for the enhancement of contrast for MRI applications and one “cold” metal (Cu, Ga, In) for future radionuclear imaging applications. Preliminary relaxivity measurements showed that the reported complexes are promising contrast agents (CA) in MRI. PMID:26664643

N-Heterocyclic carbene metal complexes: photoluminescence and applications.

PubMed

Visbal, Renso; Gimeno, M Concepción

2014-05-21

This review covers the advances made in the synthesis of luminescent transition metal complexes containing N-heterocyclic carbene (NHC) ligands. The presence of a high field strength ligand such as an NHC in the complexes gives rise to high energy emissions, and consequently, to the desired blue colour needed for OLED applications. Furthermore, the great versatility of NHC ligands for structural modifications, together with the use of other ancillary ligands in the complex, provides numerous possibilities for the synthesis of phosphorescent materials, with emission colours over the entire visible spectra and potential future applications in fields such as photochemical water-splitting, chemosensors, dye-sensitised solar cells, oxygen sensors, and medicine.

Fiberoptic sensors for rocket engine applications

NASA Technical Reports Server (NTRS)

Ballard, R. O.

1992-01-01

A research effort was completed to summarize and evaluate the current level of technology in fiberoptic sensors for possible applications in integrated control and health monitoring (ICHM) systems in liquid propellant engines. The environment within a rocket engine is particuarly severe with very high temperatures and pressures present combined with extremely rapid fluid and gas flows, and high-velocity and high-intensity acoustc waves. Application of fiberoptic technology to rocket engine health monitoring is a logical evolutionary step in ICHM development and presents a significant challenge. In this extremely harsh environment, the additional flexibility of fiberoptic techniques to augment conventional sensor technologies offer abundant future potential.

Silicon Carbide Monofilament Reinforced Titanium Composites For Space Structures: A New Material Option

NASA Astrophysics Data System (ADS)

Kyle-Henney, Stephen; Flitcroft, Stephen; Shatwell, Robert; Gibbon, David; Voss, Gary; Harkness, Patrick

2012-07-01

Silicon carbide fibre reinforced titanium composite material has been in development since the 1980s initially for high temperature structures on hypersonic vehicles (HOTOL, NASP). Since then development has focused on military and civil aircraft. Development in the European Union has reached a level of maturity where it is again being considered for space applications. Current activities include pressure vessels and studies for launch vehicles and satellite applications. The paper provides background to the technology key performance characteristics current application work and future activities. The renewed interest in hypersonic vehicles has also picked up on the potential for lightweight metallic composites.

Evaluation of a Gamma Titanium Aluminide for Hypersonic Structural Applications

NASA Technical Reports Server (NTRS)

Johnson, W. Steven; Weeks, Carrell E.

2005-01-01

Titanium matrix composites (TMCs) have been extensively evaluated for their potential to replace conventional superalloys in high temperature structural applications, with significant weight-savings while maintaining comparable mechanical properties. New gamma titanium aluminide alloys and an appropriate fiber could offer an improved TMC for use in intermediate temperature applications (400-800 C). The purpose of this investigation is the evaluation of a gamma titanium aluminide alloy with nominal composition Ti-46.5Al-4(Cr,Nb,Ta,B)at.% as a structural material in future aerospace transportation systems, where very light-weight structures are necessary to meet the goals of advanced aerospace programs.

Recent progress of carbon nanotube field emitters and their application.

PubMed

Seelaboyina, Raghunandan; Choi, Wonbong

2007-01-01

The potential of utilizing carbon nanotube field emission properties is an attractive feature for future vacuum electronic devices including: high power microwave, miniature x-ray, backlight for liquid crystal displays and flat panel displays. Their high emission current, nano scale geometry, chemical inertness and low threshold voltage for emission are attractive features for the field emission applications. In this paper we review the recent developments of carbon nanotube field emitters and their device applications. We also discuss the latest results on field emission current amplification achieved with an electron multiplier microchannel plate, and emission performance of multistage field emitter based on oxide nanowire operated in poor vacuum.

Recent advances in terahertz technology for biomedical applications.

PubMed

Sun, Qiushuo; He, Yuezhi; Liu, Kai; Fan, Shuting; Parrott, Edward P J; Pickwell-MacPherson, Emma

2017-06-01

Terahertz instrumentation has improved significantly in recent years such that THz imaging systems have become more affordable and easier to use. THz systems can now be operated by non-THz experts greatly facilitating research into many potential applications. Due to the non-ionising nature of THz light and its high sensitivity to soft tissues, there is an increasing interest in biomedical applications including both in vivo and ex vivo studies. Additionally, research continues into understanding the origin of contrast and how to interpret terahertz biomedical images. This short review highlights some of the recent work in these areas and suggests some future research directions.

Applications of mid-infrared spectroscopy in the clinical laboratory setting.

PubMed

De Bruyne, Sander; Speeckaert, Marijn M; Delanghe, Joris R

2018-01-01

Fourier transform mid-infrared (MIR-FTIR) spectroscopy is a nondestructive, label-free, highly sensitive and specific technique that provides complete information on the chemical composition of biological samples. The technique both can offer fundamental structural information and serve as a quantitative analysis tool. Therefore, it has many potential applications in different fields of clinical laboratory science. Although considerable technological progress has been made to promote biomedical applications of this powerful analytical technique, most clinical laboratory analyses are based on spectroscopic measurements in the visible or ultraviolet (UV) spectrum and the potential role of FTIR spectroscopy still remains unexplored. In this review, we present some general principles of FTIR spectroscopy as a useful method to study molecules in specimens by MIR radiation together with a short overview of methods to interpret spectral data. We aim at illustrating the wide range of potential applications of the proposed technique in the clinical laboratory setting with a focus on its advantages and limitations and discussing the future directions. The reviewed applications of MIR spectroscopy include (1) quantification of clinical parameters in body fluids, (2) diagnosis and monitoring of cancer and other diseases by analysis of body fluids, cells, and tissues, (3) classification of clinically relevant microorganisms, and (4) analysis of kidney stones, nails, and faecal fat.

A comprehensive review of electrocoagulation for water treatment: Potentials and challenges.

PubMed

Moussa, Dina T; El-Naas, Muftah H; Nasser, Mustafa; Al-Marri, Mohammed J

2017-01-15

Electrocoagulation is an effective electrochemical approach for the treatment of different types of contaminated water and has received considerable attention in recent years due its high efficiency in dealing with numerous stubborn pollutants. It has been successful in dealing with organic and inorganic contaminants with negligible or almost no generation of by-product wastes. During the past decade, vast amount of research has been devoted to utilizing electrocoagulation for the treatment of several types of wastewater, ranging from polluted groundwater to highly contaminated refinery wastewater. This paper offers a comprehensive review of recent literature that has been dedicated to utilizing electrocoagulation for water treatment, focusing on current successes on specific applications in water and wastewater treatment, as well as potentials for future applications. The paper examines such aspects as theory, potential applications, current challenges, recent developments as well as economical concerns associated with the technology. Most of the recent EC research has been focusing on pollutant-specific evaluation without paying attention to cell design, process modeling or industrial applications. This review attempts to highlight the main achievements in the area and outlines the major shortcomings with recommendations for promising research options that can enhance the technology and broaden its range of applications. Copyright © 2016 Elsevier Ltd. All rights reserved.

3D Printing: Print the future of ophthalmology.

PubMed

Huang, Wenbin; Zhang, Xiulan

2014-08-26

The three-dimensional (3D) printer is a new technology that creates physical objects from digital files. Recent technological advances in 3D printing have resulted in increased use of this technology in the medical field, where it is beginning to revolutionize medical and surgical possibilities. It is already providing medicine with powerful tools that facilitate education, surgical planning, and organ transplantation research. A good understanding of this technology will be beneficial to ophthalmologists. The potential applications of 3D printing in ophthalmology, both current and future, are explored in this article. Copyright 2014 The Association for Research in Vision and Ophthalmology, Inc.

Aerospace century XXI: Space sciences, applications, and commercial developments; Proceedings of the Thirty-third Annual AAS International Conference, Boulder, CO, Oct. 26-29, 1986

DOE Office of Scientific and Technical Information (OSTI.GOV)

Morgenthaler, G.W.; Koster, J.N.

1987-01-01

Papers are presented on rocket UV observations of Comet Halley, a space system for microgravity research, transitioning from Spacelab to Space Station science, and assemblers and future space hardware. Also considered are spatial and temporal scales of atmospheric disturbances, Doppler radar for prediction and warning, data management for the Columbus program, communications satellites of the future, and commercial launch vehicles. Other topics include space geodesy and earthquake predictions, inverted cellular radio satellite systems, material processing in space, and potential for earth observations from the manned Space Station.

ART/Ada design project, phase 1

NASA Technical Reports Server (NTRS)

1989-01-01

An Ada-Based Expert System Building Tool Design Research Project was conducted. The goal was to investigate various issues in the context of the design of an Ada-based expert system building tool. An attempt was made to achieve a comprehensive understanding of the potential for embedding expert systems in Ada systems for eventual application in future projects. The current status of the project is described by introducing an operational prototype, ART/Ada. How the project was conducted is explained. The performance of the prototype is analyzed and compared with other related works. Future research directions are suggested.

Biomedical Applications of Carbon Nanotubes: A Critical Review.

PubMed

Sharma, Priyanka; Mehra, Neelesh Kumar; Jain, Keerti; Jain, N K

2016-08-01

The convergence of nano and biotechnology is enabling scientific and technical knowledge for improving human well being. Carbon nanotubes have become most fascinating material to be studied and unveil new avenues in the field of nanobiotechnology. The nanometer size and high aspect ratio of the CNTs are the two distinct features, which have contributed to diverse biomedical applications. They have captured the attention as nanoscale materials due to their nanometric structure and remarkable list of superlative and extravagant properties that encouraged their exploitation for promising applications. Significant progress has been made in order to overcome some of the major hurdles towards biomedical application of nanomaterials, especially on issues regarding the aqueous solubility/dispersion and safety of CNTs. Functionalized CNTs have been used in drug targeting, imaging, and in the efficient delivery of gene and nucleic acids. CNTs have also demonstrated great potential in diverse biomedical uses like drug targeting, imaging, cancer treatment, tissue regeneration, diagnostics, biosensing, genetic engineering and so forth. The present review highlights the possible potential of CNTs in diagnostics, imaging and targeted delivery of bioactives and also outlines the future opportunities for biomedical applications.

Application of Electrokinetic Stabilisation (EKS) Method for Soft Soil: A Review

NASA Astrophysics Data System (ADS)

Azhar, ATS; Azim, MAM; Syakeera, NN; Jefferson, IF; Rogers, CDF

2017-08-01

Soil properties such as low shear strength, excessive compression, collapsing behavior, high swell potential are some of the undesirable properties of soils in geotechnical engineering and those properties would cause severe distress to the structures. To solve these, an innovative stabilization of Electrokinetic (EKS) has been introduced. Electrokinetic is an applicable technique to transport charged particles and fluid in an electric potential. The EKS demonstrates changes in soil pH due to electrolysis reactions, water flow between the electrodes and migration of ions towards the cathode. This treatment has proven its efficiency in consolidating organic, peat and clayey silt as well as less expensive than other methods. Otherwise, this method also gives advantage by not disturbing site. The primary objective of this review is to discuss the application of electrokinetic and to investigate the current knowledge of electrokinetic in geotechnical application through a literature search and review, including consideration of certain aspects related to the soft soil application that may be relevant to the future study and at the same time addressing some key issues and their implications on soil behaviors.

Model-data integration to improve the LPJmL dynamic global vegetation model

NASA Astrophysics Data System (ADS)

Forkel, Matthias; Thonicke, Kirsten; Schaphoff, Sibyll; Thurner, Martin; von Bloh, Werner; Dorigo, Wouter; Carvalhais, Nuno

2017-04-01

Dynamic global vegetation models show large uncertainties regarding the development of the land carbon balance under future climate change conditions. This uncertainty is partly caused by differences in how vegetation carbon turnover is represented in global vegetation models. Model-data integration approaches might help to systematically assess and improve model performances and thus to potentially reduce the uncertainty in terrestrial vegetation responses under future climate change. Here we present several applications of model-data integration with the LPJmL (Lund-Potsdam-Jena managed Lands) dynamic global vegetation model to systematically improve the representation of processes or to estimate model parameters. In a first application, we used global satellite-derived datasets of FAPAR (fraction of absorbed photosynthetic activity), albedo and gross primary production to estimate phenology- and productivity-related model parameters using a genetic optimization algorithm. Thereby we identified major limitations of the phenology module and implemented an alternative empirical phenology model. The new phenology module and optimized model parameters resulted in a better performance of LPJmL in representing global spatial patterns of biomass, tree cover, and the temporal dynamic of atmospheric CO2. Therefore, we used in a second application additionally global datasets of biomass and land cover to estimate model parameters that control vegetation establishment and mortality. The results demonstrate the ability to improve simulations of vegetation dynamics but also highlight the need to improve the representation of mortality processes in dynamic global vegetation models. In a third application, we used multiple site-level observations of ecosystem carbon and water exchange, biomass and soil organic carbon to jointly estimate various model parameters that control ecosystem dynamics. This exercise demonstrates the strong role of individual data streams on the simulated ecosystem dynamics which consequently changed the development of ecosystem carbon stocks and fluxes under future climate and CO2 change. In summary, our results demonstrate challenges and the potential of using model-data integration approaches to improve a dynamic global vegetation model.

Placing the power of real options analysis into the hands of natural resource managers - taking the next step.

PubMed

Nelson, Rohan; Howden, Mark; Hayman, Peter

2013-07-30

This paper explores heuristic methods with potential to place the analytical power of real options analysis into the hands of natural resource managers. The complexity of real options analysis has led to patchy or ephemeral adoption even by corporate managers familiar with the financial-market origins of valuation methods. Intuitively accessible methods for estimating the value of real options have begun to evolve, but their evaluation has mostly been limited to researcher-driven applications. In this paper we work closely with Bush Heritage Australia to evaluate the potential of real options analysis to support the intuitive judgement of conservation estate managers in covenanting land with uncertain future conservation value due to climate change. The results show that modified decision trees have potential to estimate the option value of covenanting individual properties while time and ongoing research resolves their future conservation value. Complementing this, Luehrman's option space has potential to assist managers with limited budgets to increase the portfolio value of multiple properties with different conservation attributes. Copyright © 2013 Elsevier Ltd. All rights reserved.

Uncertainties in the projection of species distributions related to general circulation models

PubMed Central

Goberville, Eric; Beaugrand, Grégory; Hautekèete, Nina-Coralie; Piquot, Yves; Luczak, Christophe

2015-01-01

Ecological Niche Models (ENMs) are increasingly used by ecologists to project species potential future distribution. However, the application of such models may be challenging, and some caveats have already been identified. While studies have generally shown that projections may be sensitive to the ENM applied or the emission scenario, to name just a few, the sensitivity of ENM-based scenarios to General Circulation Models (GCMs) has been often underappreciated. Here, using a multi-GCM and multi-emission scenario approach, we evaluated the variability in projected distributions under future climate conditions. We modeled the ecological realized niche (sensu Hutchinson) and predicted the baseline distribution of species with contrasting spatial patterns and representative of two major functional groups of European trees: the dwarf birch and the sweet chestnut. Their future distributions were then projected onto future climatic conditions derived from seven GCMs and four emissions scenarios using the new Representative Concentration Pathways (RCPs) developed for the Intergovernmental Panel on Climate Change (IPCC) AR5 report. Uncertainties arising from GCMs and those resulting from emissions scenarios were quantified and compared. Our study reveals that scenarios of future species distribution exhibit broad differences, depending not only on emissions scenarios but also on GCMs. We found that the between-GCM variability was greater than the between-RCP variability for the next decades and both types of variability reached a similar level at the end of this century. Our result highlights that a combined multi-GCM and multi-RCP approach is needed to better consider potential trajectories and uncertainties in future species distributions. In all cases, between-GCM variability increases with the level of warming, and if nothing is done to alleviate global warming, future species spatial distribution may become more and more difficult to anticipate. When future species spatial distributions are examined, we propose to use a large number of GCMs and RCPs to better anticipate potential trajectories and quantify uncertainties. PMID:25798227

Technical Development Path for Gas Foil Bearings

NASA Technical Reports Server (NTRS)

Dellacorte, Christopher

2016-01-01

Foil gas bearings are in widespread commercial use in air cycle machines, turbocompressors and microturbine generators and are emerging in more challenging applications such as turbochargers, auxiliary power units and propulsion gas turbines. Though not well known, foil bearing technology is well over fifty years old. Recent technological developments indicate that their full potential has yet to be realized. This paper investigates the key technological developments that have characterized foil bearing advances. It is expected that a better understanding of foil gas bearing development path will aid in future development and progress towards more advanced applications.

Nanotechnology: Future of Oncotherapy.

PubMed

Gharpure, Kshipra M; Wu, Sherry Y; Li, Chun; Lopez-Berestein, Gabriel; Sood, Anil K

2015-07-15

Recent advances in nanotechnology have established its importance in several areas including medicine. The myriad of applications in oncology range from detection and diagnosis to drug delivery and treatment. Although nanotechnology has attracted a lot of attention, the practical application of nanotechnology to clinical cancer care is still in its infancy. This review summarizes the role that nanotechnology has played in improving cancer therapy, its potential for affecting all aspects of cancer care, and the challenges that must be overcome to realize its full promise. ©2015 American Association for Cancer Research.

Metabolomics and malaria biology

PubMed Central

Lakshmanan, Viswanathan; Rhee, Kyu Y.; Daily, Johanna P.

2010-01-01

Metabolomics has ushered in a novel and multi-disciplinary realm in biological research. It has provided researchers with a platform to combine powerful biochemical, statistical, computational, and bioinformatics techniques to delve into the mysteries of biology and disease. The application of metabolomics to study malaria parasites represents a major advance in our approach towards gaining a more comprehensive perspective on parasite biology and disease etiology. This review attempts to highlight some of the important aspects of the field of metabolomics, and its ongoing and potential future applications to malaria research. PMID:20970461

Practical applications of space systems. [environmental quality and resources management

NASA Technical Reports Server (NTRS)

1975-01-01

The study was conducted to provide an opportunity for knowledgeable users to express their needs for information or services which might or might not be met by space systems, and to relate the present and potential capabilities of space systems to their needs. The needs, accomplishments to date, and future possibilities in the applications of space systems for providing food and energy, while at the same time improving and safeguarding the physical environment and the quality of life, are presented. Organizing the usage of these space systems capabilities is also discussed.

NASA GSFC Strategic Nanotechnology Interests: Symposium on High-Rate Nanoscale Printing for Devices and Structures

NASA Technical Reports Server (NTRS)

Ericsson, Aprille J.

2014-01-01

The seminars invitees include representatives from industry, nonprofit research facility and universities. The presentation provides an overview of the NASAGSFC locations, technical capabilities and applied nanotechnology interests. Initially presented are advances by the broader technological communities on current miniaturized multiscale advanced manufacturing and 3D printing products on the micro and macro scale. Briefly assessed is the potential of moving toward the nanoscale for possible space flight applications and challenges. Lastly, highlighted are GSFCs current successes in nano-technology developments and targeted future applications.

Overview on NASA's Advanced Electric Propulsion Concepts Activities

NASA Technical Reports Server (NTRS)

Frisbee, Robert H.

1999-01-01

Advanced electric propulsion research activities are currently underway that seek to addresses feasibility issues of a wide range of advanced concepts, and may result in the development of technologies that will enable exciting new missions within our solar system and beyond. Each research activity is described in terms of the present focus and potential future applications. Topics include micro-electric thrusters, electrodynamic tethers, high power plasma thrusters and related applications in materials processing, variable specific impulse plasma thrusters, pulsed inductive thrusters, computational techniques for thruster modeling, and advanced electric propulsion missions and systems studies.

Visible-light optical coherence tomography: a review

NASA Astrophysics Data System (ADS)

Shu, Xiao; Beckmann, Lisa; Zhang, Hao F.

2017-12-01

Visible-light optical coherence tomography (vis-OCT) is an emerging imaging modality, providing new capabilities in both anatomical and functional imaging of biological tissue. It relies on visible light illumination, whereas most commercial and investigational OCTs use near-infrared light. As a result, vis-OCT requires different considerations in engineering design and implementation but brings unique potential benefits to both fundamental research and clinical care of several diseases. Here, we intend to provide a summary of the development of vis-OCT and its demonstrated applications. We also provide perspectives on future technology improvement and applications.

Microencapsulation of Hepatocytes and Mesenchymal Stem Cells for Therapeutic Applications.

PubMed

Meier, Raphael P H; Montanari, Elisa; Morel, Philippe; Pimenta, Joël; Schuurman, Henk-Jan; Wandrey, Christine; Gerber-Lemaire, Sandrine; Mahou, Redouan; Bühler, Leo H

2017-01-01

Encapsulated hepatocyte transplantation and encapsulated mesenchymal stem cell transplantation are newly developed potential treatments for acute and chronic liver diseases, respectively. Cells are microencapsulated in biocompatible semipermeable alginate-based hydrogels. Microspheres protect cells against antibodies and immune cells, while allowing nutrients, small/medium size proteins and drugs to diffuse inside and outside the polymer matrix. Microencapsulated cells are assessed in vitro and designed for experimental transplantation and for future clinical applications.Here, we describe the protocol for microencapsulation of hepatocytes and mesenchymal stem cells within hybrid poly(ethylene glycol)-alginate hydrogels.

Membrane-based torque magnetometer: Enhanced sensitivity by optical readout of the membrane displacement

NASA Astrophysics Data System (ADS)

Blankenhorn, M.; Heintze, E.; Slota, M.; van Slageren, J.; Moores, B. A.; Degen, C. L.; Bogani, L.; Dressel, M.

2017-09-01

The design and realization of a torque magnetometer is reported that reads the deflection of a membrane by optical interferometry. The compact instrument allows for low-temperature measurements of tiny crystals less than a microgram with a significant improvement in sensitivity, signal-to-noise ratio as well as data acquisition time compared with conventional magnetometry and offers an enormous potential for further improvements and future applications in different fields. Magnetic measurements on single-molecule magnets demonstrate the applicability of the membrane-based torque magnetometer.

Membrane-based torque magnetometer: Enhanced sensitivity by optical readout of the membrane displacement.

PubMed

Blankenhorn, M; Heintze, E; Slota, M; van Slageren, J; Moores, B A; Degen, C L; Bogani, L; Dressel, M

2017-09-01

The design and realization of a torque magnetometer is reported that reads the deflection of a membrane by optical interferometry. The compact instrument allows for low-temperature measurements of tiny crystals less than a microgram with a significant improvement in sensitivity, signal-to-noise ratio as well as data acquisition time compared with conventional magnetometry and offers an enormous potential for further improvements and future applications in different fields. Magnetic measurements on single-molecule magnets demonstrate the applicability of the membrane-based torque magnetometer.

Applications of a shadow camera system for energy meteorology

NASA Astrophysics Data System (ADS)

Kuhn, Pascal; Wilbert, Stefan; Prahl, Christoph; Garsche, Dominik; Schüler, David; Haase, Thomas; Ramirez, Lourdes; Zarzalejo, Luis; Meyer, Angela; Blanc, Philippe; Pitz-Paal, Robert

2018-02-01

Downward-facing shadow cameras might play a major role in future energy meteorology. Shadow cameras directly image shadows on the ground from an elevated position. They are used to validate other systems (e.g. all-sky imager based nowcasting systems, cloud speed sensors or satellite forecasts) and can potentially provide short term forecasts for solar power plants. Such forecasts are needed for electricity grids with high penetrations of renewable energy and can help to optimize plant operations. In this publication, two key applications of shadow cameras are briefly presented.

FUTURE APPLICATIONS OF EXPERT SYSTEMS FOR THE EVALUATION OF ENERGY RESOURCES.

USGS Publications Warehouse

Miller, Betty M.

1988-01-01

The loss of professional experience and expertise in the domain of the earth sciences may prove to be one of the most serious outcomes of the boom-and-bust cyclic nature of the volatile energy and mining industries. Promising new applications of powerful computer systems, known as 'expert systems' or 'knowledge-based systems', are predicted for use in the earth science. These systems have the potential capability to capture and preserve the invaluable knowledge bases essential to the evaluation of US energy and mineral resources.

FUTURE APPLICATIONS OF EXPERT SYSTEMS FOR THE EVALUATION OF ENERGY RESOURCES.

USGS Publications Warehouse

Miller, B.M.

1987-01-01

The loss of professional experience and expertise in the domain of the earth sciences may prove to be one of the most serious outcomes of the boom-and-bust cyclic nature of the volatile energy and mining industries. Promising new applications of powerful computer systems, known as 'expert systems' or 'knowledge-based systems', are predicted for use in the earth sciences. These systems have the potential capability to capture and preserve the invaluable knowledge bases essential to the evaluation of the Nation's energy and mineral resources.

Quantum technology past, present, future: quantum energetics (Conference Presentation)

NASA Astrophysics Data System (ADS)

Choi, Sang H.

2017-04-01

Since the development of quantum physics in the early part of the 1900s, this field of study has made remarkable contributions to our civilization. Some of these advances include lasers, light-emitting diodes (LED), sensors, spectroscopy, quantum dots, quantum gravity and quantum entanglements. In 1998, the NASA Langley Research Center established a quantum technology committee to monitor the progress in this area and initiated research to determine the potential of quantum technology for future NASA missions. The areas of interest in quantum technology at NASA included fundamental quantum-optics materials associated with quantum dots and quantum wells, device-oriented photonic crystals, smart optics, quantum conductors, quantum information and computing, teleportation theorem, and quantum energetics. A brief review of the work performed, the progress made in advancing these technologies, and the potential NASA applications of quantum technology will be presented.

Perspectives from the NSF-sponsored workshop on Grand Challenges in Nanomaterials

NASA Astrophysics Data System (ADS)

Hull, Robert

2004-03-01

At an NSF-sponsored workshop in June 2003, about seventy research leaders in the field of nanomaterials met to discuss, explore and identify future new directions and critical needs ("Grand Challenges") for the next decade and beyond. The key pervasive theme that was identified was the need to develop techniques for assembly of nanoscaled materials over multiple lengths scales, at the levels of efficiency, economy, and precision necessary to realize broad new classes of applications in such diverse technologies as electronics, computation, telecommunications, data storage, energy storage / transmission / generation, health care, transportation, civil infrastructure, military applications, national security, and the environment. Elements of this strategy include development of new self-assembly and lithographic techniques; biologically-mediated synthesis; three-dimensional atomic-scale measurement of structure, properties and chemistry; harnessing of the sub-atomic properties of materials such as electron spin and quantum interactions; new computational methods that span all relevant length- and time- scales; a fundamental understanding of acceptable / achievable "fault tolerance" at the nanoscale; and methods for real-time and distributed sensing of nanoscale assembly. A parallel theme was the need to provide education concerning the potential, applications, and benefits of nanomaterials to all components of society and all levels of the educational spectrum. This talk will summarize the conclusions and recommendations from this workshop, and illustrate the future potential of this field through presentation of selected break-through results provided by workshop participants.

A review of volume‐area scaling of glaciers

PubMed Central

Bahr, David B.; Kaser, Georg

2015-01-01

Abstract Volume‐area power law scaling, one of a set of analytical scaling techniques based on principals of dimensional analysis, has become an increasingly important and widely used method for estimating the future response of the world's glaciers and ice caps to environmental change. Over 60 papers since 1988 have been published in the glaciological and environmental change literature containing applications of volume‐area scaling, mostly for the purpose of estimating total global glacier and ice cap volume and modeling future contributions to sea level rise from glaciers and ice caps. The application of the theory is not entirely straightforward, however, and many of the recently published results contain analyses that are in conflict with the theory as originally described by Bahr et al. (1997). In this review we describe the general theory of scaling for glaciers in full three‐dimensional detail without simplifications, including an improved derivation of both the volume‐area scaling exponent γ and a new derivation of the multiplicative scaling parameter c. We discuss some common misconceptions of the theory, presenting examples of both appropriate and inappropriate applications. We also discuss potential future developments in power law scaling beyond its present uses, the relationship between power law scaling and other modeling approaches, and some of the advantages and limitations of scaling techniques. PMID:27478877

Standardisation of magnetic nanoparticles in liquid suspension

NASA Astrophysics Data System (ADS)

Wells, James; Kazakova, Olga; Posth, Oliver; Steinhoff, Uwe; Petronis, Sarunas; Bogart, Lara K.; Southern, Paul; Pankhurst, Quentin; Johansson, Christer

2017-09-01

Suspensions of magnetic nanoparticles offer diverse opportunities for technology innovation, spanning a large number of industry sectors from imaging and actuation based applications in biomedicine and biotechnology, through large-scale environmental remediation uses such as water purification, to engineering-based applications such as position-controlled lubricants and soaps. Continuous advances in their manufacture have produced an ever-growing range of products, each with their own unique properties. At the same time, the characterisation of magnetic nanoparticles is often complex, and expert knowledge is needed to correctly interpret the measurement data. In many cases, the stringent requirements of the end-user technologies dictate that magnetic nanoparticle products should be clearly defined, well characterised, consistent and safe; or to put it another way—standardised. The aims of this document are to outline the concepts and terminology necessary for discussion of magnetic nanoparticles, to examine the current state-of-the-art in characterisation methods necessary for the most prominent applications of magnetic nanoparticle suspensions, to suggest a possible structure for the future development of standardisation within the field, and to identify areas and topics which deserve to be the focus of future work items. We discuss potential roadmaps for the future standardisation of this developing industry, and the likely challenges to be encountered along the way.

Recent advances in the fabrication and structure-specific applications of graphene-based inorganic hybrid membranes.

PubMed

Zhao, Xinne; Zhang, Panpan; Chen, Yuting; Su, Zhiqiang; Wei, Gang

2015-03-12

The preparation and applications of graphene (G)-based materials are attracting increasing interests due to their unique electronic, optical, magnetic, thermal, and mechanical properties. Compared to G-based hybrid and composite materials, G-based inorganic hybrid membrane (GIHM) offers enormous advantages ascribed to their facile synthesis, planar two-dimensional multilayer structure, high specific surface area, and mechanical stability, as well as their unique optical and mechanical properties. In this review, we report the recent advances in the technical fabrication and structure-specific applications of GIHMs with desirable thickness and compositions. In addition, the advantages and disadvantages of the methods utilized for creating GIHMs are discussed in detail. Finally, the potential applications and key challenges of GIHMs for future technical applications are mentioned.

Center for Advanced Computational Technology

NASA Technical Reports Server (NTRS)

Noor, Ahmed K.

2000-01-01

The Center for Advanced Computational Technology (ACT) was established to serve as a focal point for diverse research activities pertaining to application of advanced computational technology to future aerospace systems. These activities include the use of numerical simulations, artificial intelligence methods, multimedia and synthetic environments, and computational intelligence, in the modeling, analysis, sensitivity studies, optimization, design and operation of future aerospace systems. The Center is located at NASA Langley and is an integral part of the School of Engineering and Applied Science of the University of Virginia. The Center has four specific objectives: 1) conduct innovative research on applications of advanced computational technology to aerospace systems; 2) act as pathfinder by demonstrating to the research community what can be done (high-potential, high-risk research); 3) help in identifying future directions of research in support of the aeronautical and space missions of the twenty-first century; and 4) help in the rapid transfer of research results to industry and in broadening awareness among researchers and engineers of the state-of-the-art in applications of advanced computational technology to the analysis, design prototyping and operations of aerospace and other high-performance engineering systems. In addition to research, Center activities include helping in the planning and coordination of the activities of a multi-center team of NASA and JPL researchers who are developing an intelligent synthesis environment for future aerospace systems; organizing workshops and national symposia; as well as writing state-of-the-art monographs and NASA special publications on timely topics.

Axial Compressor Reversed Flow Performance.

DTIC Science & Technology

1985-05-01

5.3.2. Axial Tempature Profils TIme-verage axial temperature profiles were acquired through the use of exposed...on the above questions, or any additional details concerning the current application, future potential, or other value of this research. Please use the...were heavily dependent upon the model used for defining compressor post-stall performance, both steady state end transient, especially In the reve a

SWAT Model Application to Assess the Impact of Intensive Corn‐farming on Runoff, Sediments and Phosphorous loss from an Agricultural Watershed in Wisconsin

EPA Science Inventory

The potential future increase in corn-based biofuel may be expected to have a negative impact on water quality in streams and lakes of the Midwestern US due to increased agricultural chemicals usage. This study used the SWAT model to assess the impact of continuous-corn farming o...

Indium phosphide space solar cell research: Where we are and where we are going

NASA Technical Reports Server (NTRS)

Jain, R. K.; Flood, D. J.; Weinberg, Irving

1995-01-01

Indium phosphide is considered to be a strong contender for many photovoltaic space applications because of its radiation resistance and its potential for high efficiency. An overview of recent progress is presented, and possible future research directions for indium phosphide space solar cells are discussed. The topics considered include radiation damage studies and space flight experiments.

Microbiological Research Under the Nagoya Protocol: Facts and Fiction.

PubMed

Overmann, Jörg; Scholz, Amber Hartman

2017-02-01

The Nagoya Protocol is based on concepts of biological diversity that are hardly applicable to microorganisms. Because of this incongruence, the Nagoya Protocol threatens future microbial research, potentially defeating its original purpose. Countries with appropriate regulations can promote science and their bioeconomy through international collaboration and simultaneously gain a competitive advantage. Copyright © 2016 Elsevier Ltd. All rights reserved.

The role of the research simulator in the systems development of rotorcraft

NASA Technical Reports Server (NTRS)

Statler, I. C.; Deel, A.

1981-01-01

The potential application of the research simulator to future rotorcraft systems design, development, product improvement evaluations, and safety analysis is examined. Current simulation capabilities for fixed-wing aircraft are reviewed and the requirements of a rotorcraft simulator are defined. The visual system components, vertical motion simulator, cab, and computation system for a research simulator under development are described.

Literature Review of Nanosprings

DOE Office of Scientific and Technical Information (OSTI.GOV)

Peterson, Reuben James

2016-08-22

Nanosprings are helical structures grown on the nanoscale. Numerous choices exist for composition and coating which give them a wide range of possible uses. They compare favorably in some aspects to other nanostructures and unfavorably in other aspects. This paper reviews the available literature, discusses techniques for formation and coating, and explores a variety of potential applications that may be developed in the near future.

Stocking levels and underlying assumptions for uneven-aged Ponderosa Pine stands.

Treesearch

P.H. Cochran

1992-01-01

Potential Problems With Q-Values Many ponderosa pine stands have a limited number of size classes, and it may be desirable to carry very large trees through several cutting cycles. Large numbers of trees below commercial size are not needed to provide adequate numbers of future replacement trees. Under these conditions, application of stand density index (SDI) can have...

The head injured adolescent: a case report and review of the issues.

PubMed

Reiter, S; Kutcher, S P

1990-11-01

Closed head injuries in adolescents are a common problem with potentially disastrous consequences to multiple areas of functioning. Through a case presentation and literature review, this paper considers treatment issues and research applications in an adolescent population with closed head injuries. Suggestions for understanding the symptom constellations are made and directions for future research and service delivery are given.

Method and Apparatus for Precisely Applying Large Planar Equi-Biaxial Strains to a Circular Membrane

DTIC Science & Technology

2013-04-01

potential future Army applications. Electronic properties, such as dielectric strength , capacitance, resistance, and inductance, vary significantly and... dielectric strength and resistance are primarily determined by inherent bulk material properties, including microstructure, while shifts in inductance...less and a nominal thickness up to ~1 mm. 15. SUBJECT TERMS large planar equi-biaxial strain, membrane, dielectric elastomers, electromechanical

Novel Membrane Separation System for Shipboard Oily Wastewater Treatment

DTIC Science & Technology

2010-12-01

OPNAVINST 5090.1B CH-2 regulates Navy ships to the same discharge limit for bilgewater and other oily waste discharges . Future discharge limits of...applicable to all Navy ship classes. An additional benefit is the potential to remove additional constituents of concern from bilgewater discharge ...treatment system on a Navy ship ................................................................ 26! 19. Shipboard Membrane Resistance of Full-Scale

Protein-driven RNA nanostructured devices that function in vitro and control mammalian cell fate.

PubMed

Shibata, Tomonori; Fujita, Yoshihiko; Ohno, Hirohisa; Suzuki, Yuki; Hayashi, Karin; Komatsu, Kaoru R; Kawasaki, Shunsuke; Hidaka, Kumi; Yonehara, Shin; Sugiyama, Hiroshi; Endo, Masayuki; Saito, Hirohide

2017-09-14

Nucleic acid nanotechnology has great potential for future therapeutic applications. However, the construction of nanostructured devices that control cell fate by detecting and amplifying protein signals has remained a challenge. Here we design and build protein-driven RNA-nanostructured devices that actuate in vitro by RNA-binding-protein-inducible conformational change and regulate mammalian cell fate by RNA-protein interaction-mediated protein assembly. The conformation and function of the RNA nanostructures are dynamically controlled by RNA-binding protein signals. The protein-responsive RNA nanodevices are constructed inside cells using RNA-only delivery, which may provide a safe tool for building functional RNA-protein nanostructures. Moreover, the designed RNA scaffolds that control the assembly and oligomerization of apoptosis-regulatory proteins on a nanometre scale selectively kill target cells via specific RNA-protein interactions. These findings suggest that synthetic RNA nanodevices could function as molecular robots that detect signals and localize target proteins, induce RNA conformational changes, and programme mammalian cellular behaviour.Nucleic acid nanotechnology has great potential for future therapeutic applications. Here the authors build protein-driven RNA nanostructures that can function within mammalian cells and regulate the cell fate.

Solar thermal technologies - Potential benefits to U.S. utilities and industry

NASA Technical Reports Server (NTRS)

Terasawa, K. L.; Gates, W. R.

1983-01-01

Solar energy systems were investigated which complement nuclear and coal technologies as a means of reducing the U.S. dependence on imported petroleum. Solar Thermal Energy Systems (STES) represents an important category of solar energy technologies. STES can be utilized in a broad range of applications servicing a variety of economic sectors, and they can be deployed in both near-term and long-term markets. The net present value of the energy cost savings attributable to electric utility and IPH applications of STES were estimated for a variety of future energy cost scenarios and levels of R&D success. This analysis indicated that the expected net benefits of developing an STES option are significantly greater than the expected costs of completing the required R&D. In addition, transportable fuels and chemical feedstocks represent a substantial future potential market for STES. Due to the basic nature of this R&D activity, however, it is currently impossible to estimate the value of STES in these markets. Despite this fact, private investment in STES R&D is not anticipated due to the high level of uncertainty characterizing the expected payoffs. Previously announced in STAR as N83-10547

Medical telerobotic systems: current status and future trends.

PubMed

Avgousti, Sotiris; Christoforou, Eftychios G; Panayides, Andreas S; Voskarides, Sotos; Novales, Cyril; Nouaille, Laurence; Pattichis, Constantinos S; Vieyres, Pierre

2016-08-12

Teleoperated medical robotic systems allow procedures such as surgeries, treatments, and diagnoses to be conducted across short or long distances while utilizing wired and/or wireless communication networks. This study presents a systematic review of the relevant literature between the years 2004 and 2015, focusing on medical teleoperated robotic systems which have witnessed tremendous growth over the examined period. A thorough insight of telerobotics systems discussing design concepts, enabling technologies (namely robotic manipulation, telecommunications, and vision systems), and potential applications in clinical practice is provided, while existing limitations and future trends are also highlighted. A representative paradigm of the short-distance case is the da Vinci Surgical System which is described in order to highlight relevant issues. The long-distance telerobotics concept is exemplified through a case study on diagnostic ultrasound scanning. Moreover, the present review provides a classification into short- and long-distance telerobotic systems, depending on the distance from which they are operated. Telerobotic systems are further categorized with respect to their application field. For the reviewed systems are also examined their engineering characteristics and the employed robotics technology. The current status of the field, its significance, the potential, as well as the challenges that lie ahead are thoroughly discussed.