Melting in the Arctic: Preparing Now for Possibilities in the Future

DTIC Science & Technology

2016-04-04

shipping, exploration, research, tourism , military patrols, and unfortunately the potential for conflict. So far, climate change, diplomacy, and economic...presence such as shipping, exploration, research, tourism , military patrols, and unfortunately the potential for conflict. So far, climate change...3 Tourism

An Agenda for the Future of Research in Honors

ERIC Educational Resources Information Center

Mariz, George

2016-01-01

Research in honors has become a priority for the National Collegiate Honors Council (NCHC), and the phrase presents the honors community with an interesting ambiguity about the appropriate focus for future studies. Potential topics might include the progress of honors students in comparison to their non-honors cohorts; the criteria for selecting…

Planning and Conducting Research Activities.

ERIC Educational Resources Information Center

Christiansen, Richard L.

1983-01-01

Some directions and influences on dental research activities in the near future are discussed. Current challenges include international competition, fellowships, and equipment. Potential research activity includes preventive medicine, epidemiology, chronic illness, the elderly, bioengineering, materials research, nutrition, soft tissue research,…

Enhancing Interdisciplinary Human System Risk Research Through Modeling and Network Approaches

NASA Technical Reports Server (NTRS)

Mindock, Jennifer; Lumpkins, Sarah; Shelhamer, Mark

2015-01-01

NASA's Human Research Program (HRP) supports research to reduce human health and performance risks inherent in future human space exploration missions. Understanding risk outcomes and contributing factors in an integrated manner allows HRP research to support development of efficient and effective mitigations from cross-disciplinary perspectives, and to enable resilient human and engineered systems for spaceflight. The purpose of this work is to support scientific collaborations and research portfolio management by utilizing modeling for analysis and visualization of current and potential future interdisciplinary efforts.

AAC technologies for young children with complex communication needs: state of the science and future research directions.

PubMed

Light, Janice; Drager, Kathryn

2007-09-01

Augmentative and alternative communication (AAC) technologies offer the potential to provide children who have complex communication needs with access to the magic and power of communication. This paper is intended to (a) summarize the research related to AAC technologies for young children who have complex communication needs; and (b) define priorities for future research to improve AAC technologies and interventions for children with complex communication needs. With the realization of improved AAC technologies, young children with complex communication needs will have better tools to maximize their development of communication, language, and literacy skills, and attain their full potential.

Technology Candidates for Air-to-Air and Air-to-Ground Data Exchange

NASA Technical Reports Server (NTRS)

Haynes, Brian D.

2015-01-01

Technology Candidates for Air-to-Air and Air-to-Ground Data Exchange is a two-year research effort to visualize the U. S. aviation industry at a point 50 years in the future, and to define potential communication solutions to meet those future data exchange needs. The research team, led by XCELAR, was tasked with identifying future National Airspace System (NAS) scenarios, determining requirements and functions (including gaps), investigating technical and business issues for air, ground, & air-to-ground interactions, and reporting on the results. The project was conducted under technical direction from NASA and in collaboration with XCELAR's partner, National Institute of Aerospace, and NASA technical representatives. Parallel efforts were initiated to define the information exchange functional needs of the future NAS, and specific communication link technologies to potentially serve those needs. Those efforts converged with the mapping of each identified future NAS function to potential enabling communication solutions; those solutions were then compared with, and ranked relative to, each other on a technical basis in a structured analysis process. The technical solutions emerging from that process were then assessed from a business case perspective to determine their viability from a real-world adoption and deployment standpoint. The results of that analysis produced a proposed set of future solutions and most promising candidate technologies. Gap analyses were conducted at two points in the process, the first examining technical factors, and the second as part of the business case analysis. In each case, no gaps or unmet needs were identified in applying the solutions evaluated to the requirements identified. The future communication solutions identified in the research comprise both specific link technologies and two enabling technologies that apply to most or all specific links. As a result, the research resulted in a new analysis approach, viewing the underlying architecture of ground-air and air-air communications as a whole, rather than as simple "link to function" paired solutions. For the business case analysis, a number of "reference architectures" were developed for both the future technologies and the current systems, based on three typical configurations of current aircraft. Current and future costs were assigned, and various comparisons made between the current and future architectures. In general, it was assumed that if a future architecture offers lower cost than the current typical architecture, while delivering equivalent or better performance, it is likely that the future solution will gain industry acceptance. Conversely, future architectures presenting higher costs than their current counterparts must present a compelling benefit case in other areas or risk a lack of industry acceptance. The business case analysis consistently indicated lower costs for the proposed future architectures, and in most cases, significantly so. The proposed future solutions were found to offer significantly greater functionality, flexibility, and growth potential over time, at lower cost, than current systems. This was true for overall, fleet-wide equipage for domestic and oceanic air carriers, as well as for single, General Aviation (GA) aircraft. The overall research results indicate that all identified requirements can be met by the proposed solutions with significant capacity for future growth. Results also illustrate that the majority of the future communication needs can be met using currently allocated aviation RF spectrum, if used in more effective ways than it is today. A combination of such optimized aviation-specific links and commercial communication systems meets all identified needs for the 50-year future and beyond, with the caveat that a new, overall function will be needed to manage all information exchange, individual links, security, cost, and other factors. This function was labeled "Delivery Manager" (DM) within this research. DM employs a distributed client/server architecture, for both airborne and ground communications architectures. Final research results included identifying the most promising candidate technologies for the future system, conclusions and recommendations, and identifying areas where further research should be considered.

Motivators for Alzheimer's disease clinical trial participation.

PubMed

Bardach, Shoshana H; Holmes, Sarah D; Jicha, Gregory A

2018-02-01

Alzheimer's disease (AD) research progress is impeded due to participant recruitment challenges. This study seeks to better understand, from the perspective of individuals engaged in clinical trials (CTs), research motivations. Participants, or their caregivers, from AD treatment and prevention CTs were surveyed about research motivators. The 87 respondents had a mean age of 72.2, were predominantly Caucasian, 55.2% were male, and 56.3% had cognitive impairment. An overwhelming majority rated the potential to help themselves or a loved one and the potential to help others in the future as important motivators. Relatively few respondents were motivated by free healthcare, monetary rewards, or to make others happy. Recruitment efforts should focus on the potential benefit for the individual, their loved ones, and others in the future rather than free healthcare or monetary rewards.

Computers in Education: Realizing the Potential. Chairmen's Report of a Research Conference, Pittsburgh, Pennsylvania, November 20-24, 1982.

ERIC Educational Resources Information Center

Lesgold, Alan; Reif, Frederick

The future of computers in education and the research needed to realize the computer's potential are discussed in this report, which presents a summary and the conclusions from an invitational conference involving 40 computer scientists, psychologists, educational researchers, teachers, school administrators, and parents. The summary stresses the…

Persistent Possible Science Selves

ERIC Educational Resources Information Center

Mills, Leila A.; Lin, Lin

2014-01-01

This paper examines literature on the development of self-knowledge for possible selves--how an individual thinks about oneself and one's potential future selves (Markus & Nurius, 1986). Future science selves research, a recent offshoot of possible selves theories, centers on the development and loss of future possible scientific selves and…

Innovation in Flight: Research of the NASA Langley Research Center on Revolutionary Advanced Concepts for Aeronautics

NASA Technical Reports Server (NTRS)

Chambers, Joseph R.

2005-01-01

The goal of this publication is to provide an overview of the topic of revolutionary research in aeronautics at Langley, including many examples of research efforts that offer significant potential benefits, but have not yet been applied. The discussion also includes an overview of how innovation and creativity is stimulated within the Center, and a perspective on the future of innovation. The documentation of this topic, especially the scope and experiences of the example research activities covered, is intended to provide background information for future researchers.

Building electronic data infrastructure for comparative effectiveness research: accomplishments, lessons learned and future steps.

PubMed

Randhawa, Gurvaneet S

2014-11-01

There are large gaps in our knowledge on the potential impact of diagnostics and therapeutics on outcomes of patients treated in the real world. Comparative effectiveness research aims to fill these gaps to maximize effectiveness of these interventions. Health information technology has the potential to dramatically improve the practice of medicine and of research. This is an overview of about US$100 million of American Recovery and Reinvestment Act investment in 12 projects managed by the Agency for Healthcare Research and Quality to build an electronic clinical data infrastructure that connects research with healthcare delivery. The achievements and lessons learned from these projects provided a foundation for the National Patient-Centered Clinical Research Network (PCORnet)and will help to guide future infrastructure development needed to build an efficient, scalable and sustainable learning health system.

Recreational 3,4-methylenedioxymethamphetamine or 'ecstasy': Current perspective and future research prospects.

PubMed

Parrott, Andrew C; Downey, Luke A; Roberts, Carl A; Montgomery, Cathy; Bruno, Raimondo; Fox, Helen C

2017-08-01

The purpose of this article is to debate current understandings about the psychobiological effects of recreational 3,4-methylenedioxymethamphetamine (MDMA or 'ecstasy'), and recommend theoretically-driven topics for future research. Recent empirical findings, especially those from novel topic areas were reviewed. Potential causes for the high variance often found in group findings were also examined. The first empirical reports into psychobiological and psychiatric aspects from the early 1990s concluded that regular users demonstrated some selective psychobiological deficits, for instance worse declarative memory, or heightened depression. More recent research has covered a far wider range of psychobiological functions, and deficits have emerged in aspects of vision, higher cognitive skill, neurohormonal functioning, and foetal developmental outcomes. However, variance levels are often high, indicating that while some recreational users develop problems, others are less affected. Potential reasons for this high variance are debated. An explanatory model based on multi-factorial causation is then proposed. A number of theoretically driven research topics are suggested, in order to empirically investigate the potential causes for these diverse psychobiological deficits. Future neuroimaging studies should study the practical implications of any serotonergic and/or neurohormonal changes, using a wide range of functional measures.

Learning Outcomes in Sustainability Education among Future Elementary School Teachers

ERIC Educational Resources Information Center

Foley, Rider W.; Archambault, Leanna M.; Hale, Annie E.; Dong, Hsiang-Kai

2017-01-01

Universities and colleges around the world are exploring ways of reorganizing curricula to educate future leaders in sustainability. Preservice teachers hold tremendous potential to introduce concepts of sustainability far earlier than post-secondary education. However, there is little research of such efforts to yield changes in future elementary…

Use of Windbreaks for Hurricane Protection of Critical Facilities

NASA Technical Reports Server (NTRS)

Hyater-Adams, Sinone; DeYoung, Russell J.

2012-01-01

The protection of NASA Langley Research Center from future hurricanes is important in order to allow the center to fulfill its mission. The impact of the center is not only great within NASA but the economy as well. The infrastructure of the Center is under potential risk in the future because of more intense hurricanes with higher speed winds and flooding. A potential method of protecting the Center s facilities is the placement of a windbreak barrier composed of indigenous trees. The New Town program that is now in progress creates a more condensed area of focus for protection. A potential design for an efficient tree windbreak barrier for Langley Research center is proposed.

On Becoming Scholars and Activists for Disability Rights.

PubMed

Balcazar, Fabricio E; Suarez-Balcazar, Yolanda

2016-12-01

In this paper, the authors discussed the nexus between the Americans with Disabilities Act and the founding of the field of Community Psychology. Contributions of the latter and future areas of research are reviewed here in three areas of importance to both fields: Community living and participation, employment, and transition from high school. Community psychology can make potential contributions to advancing research in these three areas. Implications for future research are discussed. © Society for Community Research and Action 2016.

Teaching to Potential. Proceedings of the Regional Conference on University Teaching (2nd, Las Cruces, New Mexico, January 9-10, 1986).

ERIC Educational Resources Information Center

New Mexico State Univ., Las Cruces.

Proceedings of a regional conference on teaching to potential are presented. The 48 papers address three areas of concern: training or educating--future requirements, cultural diversity in higher education, and relating disciplinary research to university teaching. Papers and authors include: "Training or Education: Future Requirements for the…

Alternative Futures for Forest-Based Nanomaterials: An Application of the Manoa Schools Alternative Futures Method

Treesearch

David N. Bengston; J. Dator; Mike Dockry; A. Yee

2016-01-01

Forestry and forest products research has entered into a robust research agenda focused on creating nano-sized particles and nanoproducts from wood. As wood-based materials can be sustainably produced, the potential of these renewable products could be limitless and include high-end compostable electronics, paint-on solar panels, and lightweight materials for airplanes...

DOE Office of Scientific and Technical Information (OSTI.GOV)

David Kisailus; Lara Estroff; Himadri S. Gupta

The technical presentations and discussions at this symposium disseminated and assessed current research and defined future directions in biomaterials research, with a focus on structure-function relationships in biological and biomimetic composites. The invited and contributed talks covered a diverse range of topics from fundamental biology, physics, chemistry, and materials science to potential applications in developing areas such as light-weight composites, multifunctional and smart materials, biomedical engineering, and nanoscaled sensors. The invited speakers were chosen to create a stimulating program with a mixture of established and junior faculty, industrial and academic researchers, and American and international experts in the field. Thismore » symposium served as an excellent introduction to the area for younger scientists (graduate students and post-doctoral researchers). Direct interactions between participants also helped to promote potential future collaborations involving multiple disciplines and institutions.« less

Future directions for positive body image research.

PubMed

Halliwell, Emma

2015-06-01

The emergence of positive body image research during the last 10 years represents an important shift in the body image literature. The existing evidence provides a strong empirical basis for the study of positive body image and research has begun to address issues of age, gender, ethnicity, culture, development, and intervention in relation to positive body image. This article briefly reviews the existing evidence before outlining directions for future research. Specifically, six areas for future positive body image research are outlined: (a) conceptualization, (b) models, (c) developmental factors, (d) social interactions, (e) cognitive processing style, and (f) interventions. Finally, the potential role of positive body image as a protective factor within the broader body image literature is discussed. Copyright © 2015 Elsevier Ltd. All rights reserved.

Future Challenges in Library Science.

ERIC Educational Resources Information Center

Murgai, Sarla R.

This paper considers a number of potential developments for the future of library science and the roles of information professionals. Among the projections are: (1) the use of computers and management science operations research methodologies will form the basis of decision making in libraries in the future; (2) a concerted effort will be made to…

Prediction markets and their potential role in biomedical research--a review.

PubMed

Pfeiffer, Thomas; Almenberg, Johan

2010-01-01

Predictions markets are marketplaces for trading contracts with payoffs that depend on the outcome of future events. Popular examples are markets on the outcome of presidential elections, where contracts pay $1 if a specific candidate wins the election and $0 if someone else wins. Contract prices on prediction markets can be interpreted as forecasts regarding the outcome of future events. Further attractive properties include the potential to aggregate private information, to generate and disseminate a consensus among the market participants, and to offer incentives for the acquisition of information. It has been argued that these properties might be valuable in the context of scientific research. In this review, we give an overview of key properties of prediction markets and discuss potential benefits for science. To illustrate these benefits for biomedical research, we discuss an example application in the context of decision making in research on the genetics of diseases. Moreover, some potential practical problems of prediction market application in science are discussed, and solutions are outlined. Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.

Potential barge transportation for inbound corn and grain

DOT National Transportation Integrated Search

1997-12-31

This research develops a model for estimating future barge and rail rates for decision making. The Box-Jenkins and the Regression Analysis with ARIMA errors forecasting methods were used to develop appropriate models for determining future rates. A s...

Family-focused autism spectrum disorder research: a review of the utility of family systems approaches.

PubMed

Cridland, Elizabeth K; Jones, Sandra C; Magee, Christopher A; Caputi, Peter

2014-04-01

A family member with an autism spectrum disorder presents pervasive and bidirectional influences on the entire family system, suggesting a need for family-focused autism spectrum disorder research. While there has been increasing interest in this research area, family-focused autism spectrum disorder research can still be considered relatively recent, and there are limitations to the existing literature. The purpose of this article is to provide theoretical and methodological directions for future family-focused autism spectrum disorder research. In particular, this article proposes Family Systems approaches as a common theoretical framework for future family-focused autism spectrum disorder research by considering theoretical concepts such as Boundaries, Ambiguous Loss, Resilience and Traumatic Growth. We discuss reasons why these concepts are important to researching families living with autism spectrum disorder and provide recommendations for future research. The potential for research grounded in Family Systems approaches to influence clinical support services is also discussed.

Three critical questions for future research on lesbian relationships.

PubMed

Diamond, Lisa M

2017-01-02

In this article I discuss three questions that should be priorities for future research on lesbian love and relationships. The first question concerns the very definition of "lesbian relationship," given how many women may be engaged in same-sex relationships without identifying as lesbian. The second question concerns the potential influence of childhood neglect and abuse on adult women's same-sex relationships, a topic that has important implications for both psychological well-being and relationship functioning. The third question concerns the potential downsides of legal marriage for women's same-sex relationships, a topic that is particularly important in light of the newfound legal recognition of same-sex marriage in all 50 states. Although there are many understudied questions in the domain of women's same-sex relationships, research on these three questions has particularly strong potential to advance our understanding of lesbian love and relationships in important ways.

Impact of high efficiency vehicles on future fuel tax revenues in Utah.

DOT National Transportation Integrated Search

2015-05-01

The Utah Department of Transportation Research Division has analyzed the potential impact of : high-efficiency motor vehicles on future State of Utah motor fuel tax revenues used to construct and maintain the : highway network. High-efficiency motor ...

Projecting future grassland productivity to assess thesustainability of potential biofuel feedstock areas in theGreater Platte River Basin

USGS Publications Warehouse

Gu, Yingxin; Wylie, Bruce K.; Boyte, Stephen; Phuyal, Khem P.

2014-01-01

This study projects future (e.g., 2050 and 2099) grassland productivities in the Greater Platte River Basin (GPRB) using ecosystem performance (EP, a surrogate for measuring ecosystem productivity) models and future climate projections. The EP models developed from a previous study were based on the satellite vegetation index, site geophysical and biophysical features, and weather and climate drivers. The future climate data used in this study were derived from the National Center for Atmospheric Research Community Climate System Model 3.0 ‘SRES A1B’ (a ‘middle’ emissions path). The main objective of this study is to assess the future sustainability of the potential biofuel feedstock areas identified in a previous study. Results show that the potential biofuel feedstock areas (the more mesic eastern part of the GPRB) will remain productive (i.e., aboveground grassland biomass productivity >2750 kg ha−1 year−1) with a slight increasing trend in the future. The spatially averaged EPs for these areas are 3519, 3432, 3557, 3605, 3752, and 3583 kg ha−1 year−1 for current site potential (2000–2008 average), 2020, 2030, 2040, 2050, and 2099, respectively. Therefore, the identified potential biofuel feedstock areas will likely continue to be sustainable for future biofuel development. On the other hand, grasslands identified as having no biofuel potential in the drier western part of the GPRB would be expected to stay unproductive in the future (spatially averaged EPs are 1822, 1691, 1896, 2306, 1994, and 2169 kg ha−1 year−1 for site potential, 2020, 2030, 2040, 2050, and 2099). These areas should continue to be unsuitable for biofuel feedstock development in the future. These future grassland productivity estimation maps can help land managers to understand and adapt to the expected changes in future EP in the GPRB and to assess the future sustainability and feasibility of potential biofuel feedstock areas.

Recruitment of oncology nurses for Internet research: issues and future directions.

PubMed

Im, Eun-Ok; Chee, Wonshik; Lim, Hyun Ju; Bender, Melinda; Tsai, Hsiu-Min; Yang, Soon-Ok; Lee, Hungsa

2006-11-03

To provide future directions for Internet research based on issues raised during the recruitment process of an Internet survey of oncology nurses. Throughout the research process, the research staff recorded issues as they arose and wrote memos regarding recruitment issues and possible reasons for the issues. Weekly group discussions were conducted, and written records of the discussions were kept. The written memos and records were reviewed, and the content was analyzed. The recruitment issues included flexibility required, mutual trust, changing Internet dynamics, and potential selection bias. As the issues indicated, recruiting nurses for the study only through the Internet did not work well. For future Internet research, the authors suggest using multiple Internet and real settings for recruitment, a variety of strategies, the quota sampling method, and creative motivation strategies.

Satellite remote sensing, biodiversity research and conservation of the future

PubMed Central

Pettorelli, Nathalie; Safi, Kamran; Turner, Woody

2014-01-01

Assessing and predicting ecosystem responses to global environmental change and its impacts on human well-being are high priority targets for the scientific community. The potential for synergies between remote sensing science and ecology, especially satellite remote sensing and conservation biology, has been highlighted by many in the past. Yet, the two research communities have only recently begun to coordinate their agendas. Such synchronization is the key to improving the potential for satellite data effectively to support future environmental management decision-making processes. With this themed issue, we aim to illustrate how integrating remote sensing into ecological research promotes a better understanding of the mechanisms shaping current changes in biodiversity patterns and improves conservation efforts. Added benefits include fostering innovation, generating new research directions in both disciplines and the development of new satellite remote sensing products. PMID:24733945

Energy use in the marine transportation industry: Task III. Efficiency improvements; Task IV. Industry future. Final report, Volume IV. [Projections for year 2000

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

1977-12-01

Tasks III and IV measure the characteristics of potential research and development programs that could be applied to the maritime industry. It was necessary to identify potential operating scenarios for the maritime industry in the year 2000 and determine the energy consumption that would result given those scenarios. After the introductory chapter the operational, regulatory, and vessel-size scenarios for the year 2000 are developed in Chapter II. In Chapter III, future cargo flows and expected levels of energy use for the baseline 2000 projection are determined. In Chapter IV, the research and development programs are introduced into the future USmore » flag fleet and the energy-savings potential associated with each is determined. The first four appendices (A through D) describe each of the generic technologies. The fifth appendix (E) contains the baseline operating and cost parameters against which 15 program areas were evaluated. (MCW)« less

Land-use and land-cover scenarios and spatial modeling at the regional scale

USGS Publications Warehouse

Sohl, Terry L.; Sleeter, Benjamin M.

2012-01-01

Land-use and land-cover (LULC) change has altered a large part of the earth's surface. Scenarios of potential future LULC change are required in order to better manage potential impacts on biodiversity, carbon fluxes, climate change, hydrology, and many other ecological processes. The U.S. Geological Survey is analyzing potential future LULC change in the United States, using an approach based on scenario construction and spatially explicit modeling. Similar modeling techniques are being used to produce historical LULC maps from 1940 to present. With the combination of backcast and forecast LULC data, the USGS is providing consistent LULC data for historical, current, and future time frames to support a variety of research applications.

Research needs and prioritizations for studies linking dietary sugars and potentially related health outcomes

USDA-ARS?s Scientific Manuscript database

An approach developed by the Agency for Healthcare Research and Quality (AHRQ) for assessing future research needs (FRN) regarding dietary sugars was implemented. A panel of 14 stakeholders across 7 pre-defined areas of expertise (lay audience, policy maker, health provider, research funder, evidenc...

Emerging and Future Computing Paradigms and Their Impact on the Research, Training, and Design Environments of the Aerospace Workforce

NASA Technical Reports Server (NTRS)

Noor, Ahmed K. (Compiler)

2003-01-01

The document contains the proceedings of the training workshop on Emerging and Future Computing Paradigms and their impact on the Research, Training and Design Environments of the Aerospace Workforce. The workshop was held at NASA Langley Research Center, Hampton, Virginia, March 18 and 19, 2003. The workshop was jointly sponsored by Old Dominion University and NASA. Workshop attendees came from NASA, other government agencies, industry and universities. The objectives of the workshop were to a) provide broad overviews of the diverse activities related to new computing paradigms, including grid computing, pervasive computing, high-productivity computing, and the IBM-led autonomic computing; and b) identify future directions for research that have high potential for future aerospace workforce environments. The format of the workshop included twenty-one, half-hour overview-type presentations and three exhibits by vendors.

Programming research: where are we and where do we go from here?

PubMed

Koletzko, Berthold; Symonds, Michael E; Olsen, Sjurdur F

2011-12-01

Convincing evidence has accumulated to show that both pre- and postnatal nutrition preprogram long-term health, well-being, and performance until adulthood and old age. There is a very large potential in the application of this knowledge to promote public health. One of the prerequisites for translational application is to strengthen the scientific evidence. More extensive knowledge is needed (eg, on effect sizes of early life programming in contemporary populations, on specific nutritional exposures, on sensitive time periods in early life, on precise underlying mechanisms, and on potential effect differences in subgroups characterized by, eg, genetic predisposition or sex). Future programming research should aim at filling the existing gaps in scientific knowledge, consider the entire lifespan, address socioeconomic issues, and foster innovation. Research should aim at results suitable for translational application (eg, by leading to health-promoting policies and evidence-based dietary recommendations in the perinatal period). International collaboration and a close research partnership of academia, industry, and small and medium enterprises may strengthen research and innovative potential enhancing the likelihood of translational application. The scientific know-how and methodology available today allow us to take major steps forward in the near future; hence, research on nutritional programming deserves high priority.

Do Reactions of Adaptation to Disability Influence the Fluctuation of Future Time Orientation among Individuals with Spinal Cord Injuries?

ERIC Educational Resources Information Center

Martz, Erin

2004-01-01

Rehabilitation counseling involves the construction of vocational goals, which involves future-oriented thinking. Yet, research indicates that time orientations may change after the experience of a trauma. Due to the potential importance of a future time orientation (FTO) in rehabilitation counseling, predictors of an FTO were examined among 317…

International employees' concerns during serious disease outbreaks and the potential impact on business continuity: Lessons identified from the 2014-15 West African Ebola outbreak.

PubMed

Cole, Jennifer; Watkins, Chris

This paper presents the findings of research carried out into the information-seeking behaviour, and information requirements of a small sample of international workers stationed in West Africa during the Zaire Ebola virus outbreak of 2014-15. The research study under which these results were obtained was part of exploratory research for a PhD focused on the use, and potential uses, of social media platforms during serious disease outbreaks that might be used to inform policy planning for public health and emergency response interventions. Thus, the findings from this study may provide valuable insights to business continuity managers and emergency planners in making future decisions about information exchange and crisis decision-making during future serious disease outbreaks.

Melting in the Arctic: Preparing Now for Possibilities in the Future

DTIC Science & Technology

2016-04-04

shipping, exploration, research, tourism , military patrols, and unfortunately the potential for conflict. So far, climate change, diplomacy, and economic...presence such as shipping, exploration, research, tourism , military patrols, and unfortunately the potential for conflict. So far, climate change...Two, as well as the rest of the students, faculty, and staff, made this year a tremendous learning experience . ii

Practitioners' Perceptions of the Soccer Extra-Time Period: Implications for Future Research.

PubMed

Harper, Liam D; Fothergill, Melissa; West, Daniel J; Stevenson, Emma; Russell, Mark

2016-01-01

Qualitative research investigating soccer practitioners' perceptions can allow researchers to create practical research investigations. The extra-time period of soccer is understudied compared to other areas of soccer research. Using an open-ended online survey containing eleven main and nine sub questions, we gathered the perceptions of extra-time from 46 soccer practitioners, all working for different professional soccer clubs. Questions related to current practices, views on extra-time regulations, and ideas for future research. Using inductive content analysis, the following general dimensions were identified: 'importance of extra-time', 'rule changes', 'efficacy of extra-time hydro-nutritional provision', 'nutritional timing', 'future research directions', 'preparatory modulations' and 'recovery'. The majority of practitioners (63%) either agreed or strongly agreed that extra-time is an important period for determining success in knockout football match-play. When asked if a fourth substitution should be permitted in extra-time, 67% agreed. The use of hydro-nutritional strategies prior to extra-time was predominately considered important or very important. However; only 41% of practitioners felt that it was the most important time point for the use of nutritional products. A similar number of practitioners account (50%) and do not (50%) account for the potential of extra-time when training and preparing players and 89% of practitioners stated that extra-time influences recovery practices following matches. In the five minute break prior to extra-time, the following practices (in order of priority) were advocated to players: hydration, energy provision, massage, and tactical preparations. Additionally, 87% of practitioners advocate a particular nutritional supplementation strategy prior to extra-time. In order of importance, practitioners see the following as future research areas: nutritional interventions, fatigue responses, acute injury risk, recovery modalities, training paradigms, injury epidemiology, and environmental considerations. This study presents novel insight into the practitioner perceptions of extra-time and provides information to readers about current applied practices and potential future research opportunities.

Practitioners' Perceptions of the Soccer Extra-Time Period: Implications for Future Research

PubMed Central

Harper, Liam D.; Fothergill, Melissa; West, Daniel J.; Stevenson, Emma; Russell, Mark

2016-01-01

Qualitative research investigating soccer practitioners’ perceptions can allow researchers to create practical research investigations. The extra-time period of soccer is understudied compared to other areas of soccer research. Using an open-ended online survey containing eleven main and nine sub questions, we gathered the perceptions of extra-time from 46 soccer practitioners, all working for different professional soccer clubs. Questions related to current practices, views on extra-time regulations, and ideas for future research. Using inductive content analysis, the following general dimensions were identified: ‘importance of extra-time’, ‘rule changes’, ‘efficacy of extra-time hydro-nutritional provision’, ‘nutritional timing’, ‘future research directions’, ‘preparatory modulations’ and ‘recovery’. The majority of practitioners (63%) either agreed or strongly agreed that extra-time is an important period for determining success in knockout football match-play. When asked if a fourth substitution should be permitted in extra-time, 67% agreed. The use of hydro-nutritional strategies prior to extra-time was predominately considered important or very important. However; only 41% of practitioners felt that it was the most important time point for the use of nutritional products. A similar number of practitioners account (50%) and do not (50%) account for the potential of extra-time when training and preparing players and 89% of practitioners stated that extra-time influences recovery practices following matches. In the five minute break prior to extra-time, the following practices (in order of priority) were advocated to players: hydration, energy provision, massage, and tactical preparations. Additionally, 87% of practitioners advocate a particular nutritional supplementation strategy prior to extra-time. In order of importance, practitioners see the following as future research areas: nutritional interventions, fatigue responses, acute injury risk, recovery modalities, training paradigms, injury epidemiology, and environmental considerations. This study presents novel insight into the practitioner perceptions of extra-time and provides information to readers about current applied practices and potential future research opportunities. PMID:27384693

Breastfeeding and Postpartum Depression: An Overview and Methodological Recommendations for Future Research

PubMed Central

Pope, Carley J.; Mazmanian, Dwight

2016-01-01

Emerging research suggests that a relationship exists between breastfeeding and postpartum depression; however, the direction and precise nature of this relationship are not yet clear. The purpose of this paper is to provide an overview of the relationship between breastfeeding and postpartum depression as it has been examined in the empirical literature. Also, the potential mechanisms of action that have been implicated in this relationship are also explored. PubMed and PsycINFO were searched using the keywords: breastfeeding with postpartum depression, perinatal depression, postnatal depression. Results of this search showed that researchers have examined this relationship in diverse ways using diverse methodology. In particular, researchers have examined the relationships between postpartum depression and breastfeeding intention, initiation, duration, and dose. Due to a number of methodological differences among past studies we make some recommendations for future research that will better facilitate an integration of findings. Future research should (1) use standardized assessment protocols; (2) confirm diagnosis through established clinical interview when possible; (3) provide a clear operationalized definition for breastfeeding variables; (4) clearly define the postpartum period interval assessed and time frame for onset of symptoms; (5) be prospective or longitudinal in nature; and (6) take into consideration other potential risk factors identified in the empirical literature. PMID:27148457

A Bright Future for Interdisciplinary Multilingualism Research

ERIC Educational Resources Information Center

Comanaru, Ruxandra-S.; Dewaele, Jean-Marc

2015-01-01

Multilingualism is a prevalent reality in today's world. From an individual level to a societal one, multilingualism incorporates many aspects that have been studied extensively by diverse social research disciplines. The present article will explore the potential directions which multilingualism research can take, concentrating mainly on the…

Collaboration in Action: Office of Research and Development ...

EPA Pesticide Factsheets

The "Collaboration in Action: US EPA's Office of Research and Develop - Current Wildfire Research Program" was invited by the USDA's US Forest Service's Scientific Executive Committee to provide USFS scientific leadership active and potential future opportunities for cooperation/collaboration. Health impacts of wildfire smoke merit the attention and action of the US EPA and current research is supported in the ACE and SHC Research Programs. Wildland fire smoke research has taken on greater importance because the 1) contribution of wildland fire PM emissions relative to total US PM emissions is increasing, 2) the population health impacts are measurable and costly, 3) vulnerable and sensitive populations at-risk are increasing attendant to our aging U.S. population and the increasing area of the wildland-urban interface, and 4) health impacts of smoke could be minimized by identifying at-risk individuals and reducing their exposures. Examples are provided. The "Collaboration in Action: US EPA's Office of Research and Develop - Current Wildfire Research Program" was invited by the USDA's US Forest Service's Scientific Executive Committee to provide USFS scientific leadership active and potential future opportunities for cooperation/collaboration.

Challenging Futures Studies To Enhance Participatory River Basin Management

NASA Astrophysics Data System (ADS)

van der Helm, R.

Can the field of futures research help advance participatory management of river basins? This question is supposed to be answered by the present study of which this paper will mainly address the theoretical and conceptual point of view. The 2000 EU Framework directive on water emphasises at least two aspects that will mark the future management of river basins: the need for long-term planning, and a demand for participation. Neither the former nor the latter are new concepts as such, but its combination is in some sense revolutionary. Can long-term plans be made (and implemented) in a participative way, what tools could be useful in this respect, and does this lead to a satisfactory situation in terms of both reaching physical targets and enhancing social-institutional manageability? A possibly rich way to enter the discussion is to challenge futures research as a concept and a practice for enabling multiple stakeholders to design appropriate policies. Futures research is the overall field in which several methods and techniques (like scenario analysis) are mobilised to systematically think through and/or design the future. As such they have proven to be rich exercises to trigger ideas, stimulate debate and design desirable futures (and how to get there). More importantly these exercises have the capability to reconstitute actor relations, and by nature go beyond the institutional boundaries. Arguably the relation between futures research and the planning process is rather distant. Understandably commitments on the direct implementation of the results are hardly ever made, but its impact on changes in the capabilities of the network of actors involved may be large. As a hypothesis we consider that the distant link between an image of the future and the implementation in policy creates sufficient distance for actors to participate (in terms of responsibilities, legal constraints, etc.) and generate potentials, and enough degrees of freedom needed for a successful implementation. However, critical conceptual and design requirements have to be met in order to realise futures research potentials. Since the beginning of the 1990s futures studies are becoming (again) more and more widespread in many different domains (technology, education, urban development, agriculture, environment, etc.). Recently, experiences have been launched and are currently being launched in the water sector (of which the World Water Vision is a well -known - but not necessarily the most representative - example). Although futures studies on a river basin level are still scarce, they will offer already sufficient material for empirical analysis. The research, effectuated within a larger framework study on the implications of futures studies for environmental research, offers at this stage initially a conceptual understanding.

The Aims and Objectives of the Monitoring the Future Study and Progress toward Fulfilling Them as of 2001. Monitoring the Future Occasional Paper 52.

ERIC Educational Resources Information Center

Johnston, Lloyd D.; O'Malley, Patrick M.; Schulenberg, John E.; Bachman, Jerald G.

Monitoring the Future is an ongoing program of research intended to assess the changing lifestyles, values, and preferences of American youth. This publication, from the occasional paper series, describes a study that monitors drug use and potential explanatory factors among American secondary school students, college students, and young adults.…

Mediators of the Availability Heuristic in Probability Estimates of Future Events.

ERIC Educational Resources Information Center

Levi, Ariel S.; Pryor, John B.

Individuals often estimate the probability of future events by the ease with which they can recall or cognitively construct relevant instances. Previous research has not precisely identified the cognitive processes mediating this "availability heuristic." Two potential mediators (imagery of the event, perceived reasons or causes for the…

Premises, Promises, and Potential Payoffs of Responsible Health Education.

ERIC Educational Resources Information Center

Seffrin, John R.

1997-01-01

This paper examines the history and future of health education. Data from an American Cancer Society study exemplify how well-designed, carefully conducted research can impact current understanding and future decisions in health education. Health educators' roles in making health education a national priority are discussed. (SM)

The Future of an Occupational Health Unit in Khartoum University, The Sudan

PubMed Central

Khogali, Mustafa

1966-01-01

A brief geographical and economic review of the Sudan has been attempted. Occupational health problems of the present and future have been outlined. The potential and intended functions of an occupational health unit are defined. The importance of teaching, surveying industry, and research is stressed. PMID:5929691

Theory of Gas Adsorption in Carbon Nanostructures

DTIC Science & Technology

2003-05-20

Johnson, "Histogram reweighting and finite size Scaling study of the Lennard - Jones fluids", Fluid Phase Equilibria, 187-188, 171-191 (2001). 19.Wei...nature of matter, with enormous potential for applications. The research continues, undiminished in intensity, in our laboratories and many others...pair potential is needed than the usually assumed free space interaction. These calculations suggest a few possible directions for future research

Collaboration in Action: Office of Research and Development (ORD) at the US Environmental Protection Agency (USEPA)-Current Wildfire Program

EPA Science Inventory

The "Collaboration in Action: US EPA's Office of Research and Develop - Current Wildfire Research Program" was invited by the USDA's US Forest Service's Scientific Executive Committee to provide USFS scientific leadership active and potential future opportunities for co...

Salt Power: Is Neptune's Ole Salt a Tiger in the Tank?

ERIC Educational Resources Information Center

Wick, Gerry Shishin

1979-01-01

Discussed is the utilization of salinity-gradient energy as a potential source of power. Detailed are the scientific principles, potential sources, latest research, and environmental effects associated with this alternative energy source. The future prospects are addressed. (BT)

Microbial Cellulases and Their Industrial Applications

PubMed Central

Kuhad, Ramesh Chander; Gupta, Rishi; Singh, Ajay

2011-01-01

Microbial cellulases have shown their potential application in various industries including pulp and paper, textile, laundry, biofuel production, food and feed industry, brewing, and agriculture. Due to the complexity of enzyme system and immense industrial potential, cellulases have been a potential candidate for research by both the academic and industrial research groups. Nowadays, significant attentions have been devoted to the current knowledge of cellulase production and the challenges in cellulase research especially in the direction of improving the process economics of various industries. Scientific and technological developments and the future prospects for application of cellulases in different industries are discussed in this paper. PMID:21912738

Human Research Program Human Health Countermeasures Element Nutrition Risk Standing Review Panel

NASA Technical Reports Server (NTRS)

Bistrian, Bruce

2009-01-01

The Nutrition Risk Standing Review Panel (SRP) reviewed and discussed the specific gaps and tasks for the Human Health Countermeasures (HHC) Element related to nutrition identified in the Human Research Program (HRP) Integrated Research Plan. There was general consensus that the described gaps and proposed tasks were critical to future NASA mission success. The SRP acknowledged the high scientific quality of the work currently being undertaken by the Nutritional Biochemistry group under the direction of Dr. Scott Smith. In review of the entire HRP, four new gaps were identified that complement the Element's existing research activities. Given the limitations of ground-based analogs for many of the unique physiological and metabolic alterations in space, future studies are needed to quantify nutritional factors that change during actual space flight. In addition, future tasks should seek to better evaluate the time course of physiological and metabolic alterations during flight to better predict alterations during longer duration missions. Finally, given the recent data suggesting a potential role for increased inflammatory responses during space flight, the role of inflammation needs to be explored in detail, including the development of potential countermeasures and new ground based analogs, if this possibility is confirmed.

Why System Safety Professionals Should Read Accident Reports

NASA Technical Reports Server (NTRS)

Holloway, C. M.; Johnson, C. W.

2006-01-01

System safety professionals, both researchers and practitioners, who regularly read accident reports reap important benefits. These benefits include an improved ability to separate myths from reality, including both myths about specific accidents and ones concerning accidents in general; an increased understanding of the consequences of unlikely events, which can help inform future designs; a greater recognition of the limits of mathematical models; and guidance on potentially relevant research directions that may contribute to safety improvements in future systems.

Selective mutism: an update and suggestions for future research.

PubMed

Scott, Samantha; Beidel, Deborah C

2011-08-01

Speculation continues regarding the accurate classification of selective mutism and potential etiologic factors. Current research has shed some light on several factors that may predispose some children to this disorder, but conclusions are difficult to draw due to reliance on subjective measures, few comparison groups, and/or limited theoretical grounding. This article provides an update on recent efforts to elucidate the etiologic pathways of selective mutism and on the current debate regarding its strong overlap with anxiety disorders, most notably social phobia. An additional attempt is made to examine findings based on a developmental perspective that accounts for multiple pathways, context, and the developmental stage of the child. Emotion regulation theory is offered as a potential factor in why some children may be more vulnerable to the etiologic factors described. Suggestions for future research are offered based on this integration of information.

Intelligent Agents and Their Potential for Future Design and Synthesis Environment

NASA Technical Reports Server (NTRS)

Noor, Ahmed K. (Compiler); Malone, John B. (Compiler)

1999-01-01

This document contains the proceedings of the Workshop on Intelligent Agents and Their Potential for Future Design and Synthesis Environment, held at NASA Langley Research Center, Hampton, VA, September 16-17, 1998. The workshop was jointly sponsored by the University of Virginia's Center for Advanced Computational Technology and NASA. Workshop attendees came from NASA, industry and universities. The objectives of the workshop were to assess the status of intelligent agents technology and to identify the potential of software agents for use in future design and synthesis environment. The presentations covered the current status of agent technology and several applications of intelligent software agents. Certain materials and products are identified in this publication in order to specify adequately the materials and products that were investigated in the research effort. In no case does such identification imply recommendation or endorsement of products by NASA, nor does it imply that the materials and products are the only ones or the best ones available for this purpose. In many cases equivalent materials and products are available and would probably produce equivalent results.

Future Secretariat: an innovation research coordination and governance structure

NASA Astrophysics Data System (ADS)

Ojima, D. S.; Johan, R.; Cramer, W.; Fukushi, K.; Allard, S.

2014-12-01

Future Earth, an emerging global sustainability research program, will be managed by a novel, internationally distributed secretariat spanning the globe and providing a platform for co-design, co-production, and co-delivery of knowledge to support research on the earth system, global development and transformation toward sustainability. The Future Earth secretariat has an innovative structure consisting of five global hubs functioning as a single entity; these hubs are located in Canada, Japan, France, Sweden, and the United States. The secretariat's reach is extended through a set of regional hubs covering Latin America, the Middle East, Africa, Europe, and Asia, with the potential to expand to additional areas. This secretariat will operate under the auspices of the Future Earth Governing Council The Future Earth Secretariat will support and enable the implementation of knowledge-sharing between research and stakeholder communities to enable society to cope with and to alter global environmental trends, and to transition society toward sustainability. The secretariat will provide coordination support to over 25 global environmental core projects and committees; coordinate scientific work across the whole Future Earth agenda; develop and implement innovative mechanisms for bottom-up inputs, synthesis and integration. Future Earth, as a research program, aims to support global transformations toward sustainability through partnerships among scientific and stakeholder communities worldwide. It brings together existing international environmental research core projects associated with DIVERSITAS, the International Geosphere-Biosphere Programme, the International Human Dimensions Programme, and the World Climate Research Programme—to support coordinated, interdisciplinary research that can be used by decision makers seeking to reduce their impact and provide more sustainable products and services. USGCRP partners with Future Earth through scientific participation in and annual funding for its constituent programs.

Gambling Disorder in Veterans: A Review of the Literature and Implications for Future Research.

PubMed

Levy, Lauren; Tracy, J Kathleen

2018-02-09

To review the scientific literature examining gambling behavior in military veterans in order to summarize factors associated with gambling behavior in this population. Database searches were employed to identify articles specifically examining gambling behavior in military veterans. Cumulative search results identified 52 articles (1983-2017) examining gambling behavior in veteran populations. Articles generally fell into one or more of the following categories: prevalence, psychological profiles and psychiatric comorbidities, treatment evaluations, measurement, and genetic contributions to gambling disorder. Results from reviewed articles are presented and implications for future research discussed. Research to date has provided an excellent foundation to inform potential screening, intervention and research activities going forward. The authors suggest that a public health approach to future research endeavors would strengthen the evidence base regarding gambling in veteran populations and better inform strategies for screening, prevention and treatment.

Commentary: The Development of Creativity--Ability, Motivation, and Potential

ERIC Educational Resources Information Center

Silvia, Paul J.; Christensen, Alexander P.; Cotter, Katherine N.

2016-01-01

A major question for research on the development of creativity is whether it is interested in "creative potential" (a prospective approach that uses measures early in life to predict adult creativity) or in children's creativity for its own sake. We suggest that a focus on potential for future creativity diminishes the fascinating…

Quantitative comparison of cognitive behavioral therapy and music therapy research: a methodological best-practices analysis to guide future investigation for adult psychiatric patients.

PubMed

Silverman, Michael J

2008-01-01

While the music therapy profession is relatively young and small in size, it can treat a variety of clinical populations and has established a diverse research base. However, although the profession originated working with persons diagnosed with mental illnesses, there is a considerable lack of quantitative research concerning the effects of music therapy with this population. Music therapy clinicians and researchers have reported on this lack of evidence and the difficulty in conducting psychosocial research on their interventions (Choi, 1997; Silverman, 2003a). While published studies have provided suggestions for future research, no studies have provided detailed propositions for the methodology and design of meticulous high quality randomized controlled psychiatric music therapy research. How do other psychotherapies accomplish their databases and could the music therapy field borrow from their rigorous "methodological best practices" to strengthen its own literature base? Therefore, as the National Institutes of Mental Health state the treatment of choice for evidence-based psychotherapy is cognitive behavioral therapy (CBT), aspects of this psychotherapy's literature base were analyzed. The purpose of this literature analysis was to (a) analyze and identify components of high-quality quantitative CBT research for adult psychiatric consumers, (b) analyze and identify the variables and other elements of existing quantitative psychiatric music therapy research for adult consumers, and (c) compare the two data sets to identify the best methodological designs and variables for future quantitative music therapy research with the mental health population. A table analyzing randomized and thoroughly controlled studies involving the use of CBT for persons with severe mental illnesses is included to determine chief components of high-quality experimental research designs and implementation of quantitative clinical research. The table also shows the same analyzed components for existing quantitative psychiatric music therapy research with adult consumers, thus highlighting potential areas and elements for future investigations. A second table depicts a number of potential dependent measures and their sources to be evaluated in future music therapy studies. A third table providing suggestions for future research is derived from a synthesis of the tables and is included to guide researchers and encourage the advancement and expansion of the current literature base. The body of the paper is a discussion of the results of the literature analysis derived from the tables, meta-analyses, and reviews of literature. It is hoped that this report will lead to the addition of future high-quality quantitative research to the psychiatric music therapy literature base and thus provide evidence-based services to as many persons with mental illnesses as possible.

The Past, Present, and Future of Research in Distance Education: Results of a Content Analysis

ERIC Educational Resources Information Center

Lee, Youngmin; Driscoll, Marcy P.; Nelson, David W.

2005-01-01

The articles published in four prominent distance education journals between 1997 and 2002 were categorized and the references cited were tallied. The study provides an opportunity to examine research topics, methods, and citation trends. The results can be used to review current research trends and to explore potential research directions.…

The Past, Present, and Future of Research in Distance Education: Results of a Content Analysis

ERIC Educational Resources Information Center

Lee, Youngmin; Driscoll, Marcy P.; Nelson, David W.

2004-01-01

The articles published in four prominent distance education journals between 1997 and 2002 were categorized and the references cited were tallied. The study provides an opportunity to examine research topics, methods, and citation trends. The results can be used to review current research trends and to explore potential research directions.

Research in Modeling and Simulation for Airspace Systems Innovation

NASA Technical Reports Server (NTRS)

Ballin, Mark G.; Kimmel, William M.; Welch, Sharon S.

2007-01-01

This viewgraph presentation provides an overview of some of the applied research and simulation methodologies at the NASA Langley Research Center that support aerospace systems innovation. Risk assessment methodologies, complex systems design and analysis methodologies, and aer ospace operations simulations are described. Potential areas for future research and collaboration using interactive and distributed simula tions are also proposed.

The scientific research potential of virtual worlds.

PubMed

Bainbridge, William Sims

2007-07-27

Online virtual worlds, electronic environments where people can work and interact in a somewhat realistic manner, have great potential as sites for research in the social, behavioral, and economic sciences, as well as in human-centered computer science. This article uses Second Life and World of Warcraft as two very different examples of current virtual worlds that foreshadow future developments, introducing a number of research methodologies that scientists are now exploring, including formal experimentation, observational ethnography, and quantitative analysis of economic markets or social networks.

Breast magnetic resonance elastography: a review of clinical work and future perspectives.

PubMed

Bohte, A E; Nelissen, J L; Runge, J H; Holub, O; Lambert, S A; de Graaf, L; Kolkman, S; van der Meij, S; Stoker, J; Strijkers, G J; Nederveen, A J; Sinkus, R

2018-05-30

This review on magnetic resonance elastography (MRE) of the breast provides an overview of available literature and describes current developments in the field of breast MRE, including new transducer technology for data acquisition and multi-frequency-derived power-law behaviour of tissue. Moreover, we discuss the future potential of breast MRE, which goes beyond its original application as an additional tool in differentiating benign from malignant breast lesions. These areas of ongoing and future research include MRE for pre-operative tumour delineation, staging, monitoring and predicting response to treatment, as well as prediction of the metastatic potential of primary tumours. Copyright © 2018 John Wiley & Sons, Ltd.

The first GCC Marine Biotechnology Symposium: Emerging Opportunities and Future Perspectives.

PubMed

Goddard, Stephen; Delghandi, Madjid; Dobretsov, Sergey; Al-Oufi, Hamed; Al-Habsi, Saoud; Burgess, J Grant

2015-06-01

With its diverse, living marine resources and rapidly growing educational and research infrastructure, the Sultanate of Oman is well-positioned to take advantage of the commercial opportunities presented by marine biotechnology. In recognition of potential development, an international symposium, Marine Biotechnology-Emerging Opportunities and Future Perspectives, was held in Muscat, November 12-13, 2013. Three keynote addresses were given, 23 oral presentations made, and a poster exhibition held. The final session reviewed national and regional issues, and the delegates agreed informally on a number of future actions. The potential for future development of marine biotechnology was recognized by all delegates, and following the symposium, they were surveyed for their views on how best to sustain and develop new activities. One hundred percent of respondents found the meeting useful and would support future symposia in the region. Fifty-one percent of Omani respondents recognized major organizational challenges and obstacles to the development of marine biotechnology compared with 23 % of overseas respondents. The need for greater collaboration between research institutions within the GCC region was recognized by 98 % of all respondents. The presentations and survey outcomes are reviewed in this paper.

Preparing ICUs for pandemics.

PubMed

Gabriel, Lucinda E K; Webb, Steve A R

2013-10-01

Influenza pandemics occur intermittently and represent an existential global infectious diseases threat. The purpose of this review is to describe clinical and research preparedness for future pandemics. Pandemic influenza typically results in large numbers of individuals with life-threatening pneumonia requiring treatment in ICUs. Clinical preparedness of ICUs relates to planning to provide increased 'surge' capacity to meet increased demand and requires consideration of staffing, equipment and consumables, bed-space availability and management systems. Research preparedness is also necessary, as timely clinical research has the potential to change the trajectory of a pandemic. The clinical research response during the 2009 H1N1 influenza pandemic was suboptimal. Better planning is necessary to optimize both clinical and research responses to future pandemics.

Multiscale Modeling, Simulation and Visualization and Their Potential for Future Aerospace Systems

NASA Technical Reports Server (NTRS)

Noor, Ahmed K. (Compiler)

2002-01-01

This document contains the proceedings of the Training Workshop on Multiscale Modeling, Simulation and Visualization and Their Potential for Future Aerospace Systems held at NASA Langley Research Center, Hampton, Virginia, March 5 - 6, 2002. The workshop was jointly sponsored by Old Dominion University's Center for Advanced Engineering Environments and NASA. Workshop attendees were from NASA, other government agencies, industry, and universities. The objectives of the workshop were to give overviews of the diverse activities in hierarchical approach to material modeling from continuum to atomistics; applications of multiscale modeling to advanced and improved material synthesis; defects, dislocations, and material deformation; fracture and friction; thin-film growth; characterization at nano and micro scales; and, verification and validation of numerical simulations, and to identify their potential for future aerospace systems.

A review of current methods using bacteriophages in live animals, food and animal products intended for human consumption.

PubMed

Cooper, Ian R

2016-11-01

Bacteriophages are utilised in the food industry as biocontrol agents to reduce the load of bacteria, and thus reduce potential for human infection. This review focuses on current methods using bacteriophages within the food chain. Limitations of research will be discussed, and the potential for future food-based bacteriophage research. Copyright © 2016 Elsevier B.V. All rights reserved.

[Research interest and recruitment potential--medical students and research].

PubMed

Lehmann, A K; Hexeberg, E; Engebråten, O; Bjugn, R

1992-06-30

A questionnaire survey on scientific interest among 324 medical students at the University of Bergen in 1990 showed that 14% of the students had already participated in medical research programmes (10% still research trainees). In addition, 45% had considered starting working as a research trainee while a student. Many were discouraged, however, by the problem of finding a suitable supervisor. Relatively more of the male students expressed considerable interest in science (32 versus 22% of the females). The medical students already recruited to scientific work stressed the importance of scientific experience for their future career. The faculty has recently made participation in research projects compulsory. The personal supervision during this short period (6-8 weeks) will probably have major impact on the interest in research and the recruitment of future medical research trainees.

Fuels research: Fuel thermal stability overview

NASA Technical Reports Server (NTRS)

Cohen, S. M.

1980-01-01

Alternative fuels or crude supplies are examined with respect to satisfying aviation fuel needs for the next 50 years. The thermal stability of potential future fuels is discussed and the effects of these characteristics on aircraft fuel systems are examined. Advanced fuel system technology and design guidelines for future fuels with lower thermal stability are reported.

Future Land-Use Changes and the Potential for Novelty in Ecosystems of the United States

Treesearch

Sebastian Martinuzzi; Gregorio I. Gavier-Pizarro; Ariel E. Lugo; Volker C. Radeloff

2015-01-01

Rapid global changes due to changing land use, climate, and non-native species are altering environmental conditions, resulting in more novel communities with unprecedented species combinations. Understanding how future anthropogenic changes may affect novelty in ecosystems is important to advance environmental management and ecological research in the Anthropocene....

Federal Expenditures on Infants and Toddlers in 2007

ERIC Educational Resources Information Center

Macomber, Jennifer; Isaacs, Julia; Vericker, Tracy; Kent, Adam; Johnson, Paul

2009-01-01

Research suggests that investing in young children can help build a strong future workforce, improve children's educational success and health, and potentially reduce some of the social ills that drain the nation's resources and will. To have an informed conversation about future investments, it is important to start from an understanding of the…

Marathon Groups. Facilitating the Personal Growth of Imprisoned, Black Female Heroin Abusers.

ERIC Educational Resources Information Center

Page, Richard C.; Kubiak, Larry

1978-01-01

Apparent success of the marathon groups in altering the perceptions of Black female heroin addicts toward the future, counseling, and themselves offers preliminary evidence that marathons may have potential as a counseling strategy with these clients. Future research needs to be performed to substantiate or reject these findings. (Author/PD)

Feeling Closer to the Future Self and Doing Better: Temporal Psychological Mechanisms Underlying Academic Performance

ERIC Educational Resources Information Center

Adelman, Robert Mark; Herrmann, Sarah D.; Bodford, Jessica E.; Barbour, Joseph E.; Graudejus, Oliver; Okun, Morris A.; Kwan, Virginia S. Y.

2017-01-01

This research examined the function of future self-continuity and its potential downstream consequences for academic performance through relations with other temporal psychological factors and self-control. We also addressed the influence of cultural factors by testing whether these relations differed by college generation status. Undergraduate…

A Brief Targeted Review of Susceptibility Factors, Environmental Exposures, Asthma Incidence, and Recommendations for Future Asthma Incidence Research

PubMed Central

Yeatts, Karin; Sly, Peter; Shore, Stephanie; Weiss, Scott; Martinez, Fernando; Geller, Andrew; Bromberg, Philip; Enright, Paul; Koren, Hillel; Weissman, David; Selgrade, MaryJane

2006-01-01

Relative to research on effects of environmental exposures on exacerbation of existing asthma, little research on incident asthma and environmental exposures has been conducted. However, this research is needed to better devise strategies for the prevention of asthma. The U.S. Environmental Protection Agency (EPA) and National Institute of Environmental Health Sciences held a conference in October 2004 to collaboratively discuss a future research agenda in this area. The first three articles in this mini-monograph summarize the discussion on potential putative environmental exposure; they include an overview of asthma and conclusions of the workshop participants with respect to public health actions that could currently be applied to the problem and research needs to better understand and control the induction and incidence of asthma, the potential role of indoor/outdoor air pollutants in the induction of asthma), and biologics in the induction of asthma. Susceptibility is a key concept in the U.S. EPA “Asthma Research Strategy” document and is associated with the U.S. EPA framework of protecting vulnerable populations from potentially harmful environmental exposures. Genetics, age, and lifestyle (obesity, diet) are major susceptibility factors in the induction of asthma and can interact with environmental exposures either synergistically or antagonistically. Therefore, in this fourth and last article we consider a number of “susceptibility factors” that potentially influence the asthmatic response to environmental exposures and propose a framework for developing research hypotheses regarding the effects of environmental exposures on asthma incidence and induction. PMID:16581558

Research Technology

NASA Image and Video Library

2002-07-01

Dr. Tom Markusic, a propulsion research engineer at the Marshall Space Flight Center (MSFC), adjusts a diagnostic laser while a pulsed plasma thruster (PPT) fires in a vacuum chamber in the background. NASA/MSFC's Propulsion Research Center (PRC) is presently investigating plasma propulsion for potential use on future nuclear-powered spacecraft missions, such as human exploration of Mars.

Quantitative Research Methods in Chaos and Complexity: From Probability to Post Hoc Regression Analyses

ERIC Educational Resources Information Center

Gilstrap, Donald L.

2013-01-01

In addition to qualitative methods presented in chaos and complexity theories in educational research, this article addresses quantitative methods that may show potential for future research studies. Although much in the social and behavioral sciences literature has focused on computer simulations, this article explores current chaos and…

The Emergence of Environmental Health Literacy—From Its Roots to Its Future Potential

PubMed Central

Finn, Symma; O’Fallon, Liam

2015-01-01

Background: Environmental health literacy (EHL) is coalescing into a new subdiscipline that combines key principles and procedural elements from the fields of risk communication, health literacy, environmental health sciences (EHS), communications research, and safety culture. These disciplines have contributed unique expertise and perspectives to the development of EHL. Since 1992, the National Institute of Environmental Health Sciences (NIEHS) has contributed to the evolution of EHL and now seeks to stimulate its scientific advancement and rigor. Objectives: The principal objective of this article is to stimulate a conversation on, and advance research in, EHL. Discussion: In this article, we propose a definition of and conceptual framework for EHL, describe EHL in its social and historical context, identify the complementary fields and domains where EHL is being defined and implemented, and outline a research agenda. Extensive reviews of web and literature searches indicate that the concept of EHL is evolving rapidly, as are the definitions of its scope and inquiry. Although several authors have outlined different frameworks, we believe that a more nuanced model based on Bloom’s taxonomy is better suited to EHL and to future research in this area. Conclusions: We posit that EHL can potentially benefit the conduct and outcomes of community-engaged and health disparities EHS research and can ensure that the translation of research findings will lead to greater understanding of specific risks, reduction of exposures, and improvement of health outcomes for individuals and communities. We provide four recommendations to advance work in EHL. Citation: Finn S, O’Fallon L. 2017. The emergence of environmental health literacy—from its roots to its future potential. Environ Health Perspect 125:495–501; http://dx.doi.org/10.1289/ehp.1409337 PMID:26126293

The future is 'ambient'

NASA Astrophysics Data System (ADS)

Lugmayr, Artur

2006-02-01

The research field of ambient media starts to spread rapidly and first applications for consumer homes are on the way. Ambient media is the logical continuation of research around media. Media has been evolving from old media (e.g. print media), to integrated presentation in one form (multimedia - or new media), to generating a synthetic world (virtual reality), to the natural environment is the user-interface (ambient media), and will be evolving towards real/synthetic undistinguishable media (bio-media or bio-multimedia). After the IT bubble was bursting, multimedia was lacking a vision of potential future scenarios and applications. Within this research paper the potentials, applications, and market available solutions of mobile ambient multimedia are studied. The different features of ambient mobile multimedia are manifold and include wearable computers, adaptive software, context awareness, ubiquitous computers, middleware, and wireless networks. The paper especially focuses on algorithms and methods that can be utilized to realize modern mobile ambient systems.

Childhood leukaemia risks: from unexplained findings near nuclear installations to recommendations for future research.

PubMed

Laurier, D; Grosche, B; Auvinen, A; Clavel, J; Cobaleda, C; Dehos, A; Hornhardt, S; Jacob, S; Kaatsch, P; Kosti, O; Kuehni, C; Lightfoot, T; Spycher, B; Van Nieuwenhuyse, A; Wakeford, R; Ziegelberger, G

2014-09-01

Recent findings related to childhood leukaemia incidence near nuclear installations have raised questions which can be answered neither by current knowledge on radiation risk nor by other established risk factors. In 2012, a workshop was organised on this topic with two objectives: (a) review of results and discussion of methodological limitations of studies near nuclear installations; (b) identification of directions for future research into the causes and pathogenesis of childhood leukaemia. The workshop gathered 42 participants from different disciplines, extending widely outside of the radiation protection field. Regarding the proximity of nuclear installations, the need for continuous surveillance of childhood leukaemia incidence was highlighted, including a better characterisation of the local population. The creation of collaborative working groups was recommended for consistency in methodologies and the possibility of combining data for future analyses. Regarding the causes of childhood leukaemia, major fields of research were discussed (environmental risk factors, genetics, infections, immunity, stem cells, experimental research). The need for multidisciplinary collaboration in developing research activities was underlined, including the prevalence of potential predisposition markers and investigating further the infectious aetiology hypothesis. Animal studies and genetic/epigenetic approaches appear of great interest. Routes for future research were pointed out.

Current Status and Recommendations for the Future of Research, Teaching, and Testing in the Biological Sciences of Radiation Oncology: Report of the American Society for Radiation Oncology Cancer Biology/Radiation Biology Task Force, Executive Summary

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wallner, Paul E., E-mail: pwallner@theabr.org; Anscher, Mitchell S.; Barker, Christopher A.

In early 2011, a dialogue was initiated within the Board of Directors (BOD) of the American Society for Radiation Oncology (ASTRO) regarding the future of the basic sciences of the specialty, primarily focused on the current state and potential future direction of basic research within radiation oncology. After consideration of the complexity of the issues involved and the precise nature of the undertaking, in August 2011, the BOD empanelled a Cancer Biology/Radiation Biology Task Force (TF). The TF was charged with developing an accurate snapshot of the current state of basic (preclinical) research in radiation oncology from the perspective ofmore » relevance to the modern clinical practice of radiation oncology as well as the education of our trainees and attending physicians in the biological sciences. The TF was further charged with making suggestions as to critical areas of biological basic research investigation that might be most likely to maintain and build further the scientific foundation and vitality of radiation oncology as an independent and vibrant medical specialty. It was not within the scope of service of the TF to consider the quality of ongoing research efforts within the broader radiation oncology space, to presume to consider their future potential, or to discourage in any way the investigators committed to areas of interest other than those targeted. The TF charge specifically precluded consideration of research issues related to technology, physics, or clinical investigations. This document represents an Executive Summary of the Task Force report.« less

Current status and recommendations for the future of research, teaching, and testing in the biological sciences of radiation oncology: report of the American Society for Radiation Oncology Cancer Biology/Radiation Biology Task Force, executive summary.

PubMed

Wallner, Paul E; Anscher, Mitchell S; Barker, Christopher A; Bassetti, Michael; Bristow, Robert G; Cha, Yong I; Dicker, Adam P; Formenti, Silvia C; Graves, Edward E; Hahn, Stephen M; Hei, Tom K; Kimmelman, Alec C; Kirsch, David G; Kozak, Kevin R; Lawrence, Theodore S; Marples, Brian; McBride, William H; Mikkelsen, Ross B; Park, Catherine C; Weidhaas, Joanne B; Zietman, Anthony L; Steinberg, Michael

2014-01-01

In early 2011, a dialogue was initiated within the Board of Directors (BOD) of the American Society for Radiation Oncology (ASTRO) regarding the future of the basic sciences of the specialty, primarily focused on the current state and potential future direction of basic research within radiation oncology. After consideration of the complexity of the issues involved and the precise nature of the undertaking, in August 2011, the BOD empanelled a Cancer Biology/Radiation Biology Task Force (TF). The TF was charged with developing an accurate snapshot of the current state of basic (preclinical) research in radiation oncology from the perspective of relevance to the modern clinical practice of radiation oncology as well as the education of our trainees and attending physicians in the biological sciences. The TF was further charged with making suggestions as to critical areas of biological basic research investigation that might be most likely to maintain and build further the scientific foundation and vitality of radiation oncology as an independent and vibrant medical specialty. It was not within the scope of service of the TF to consider the quality of ongoing research efforts within the broader radiation oncology space, to presume to consider their future potential, or to discourage in any way the investigators committed to areas of interest other than those targeted. The TF charge specifically precluded consideration of research issues related to technology, physics, or clinical investigations. This document represents an Executive Summary of the Task Force report. Copyright © 2014 Elsevier Inc. All rights reserved.

Designing PISA-Like Mathematics Tasks In Indonesia: Experiences and Challenges

NASA Astrophysics Data System (ADS)

Zulkardi, Z.; Kohar, A. W.

2018-01-01

The insignificant improvement of Indonesian students in PISA mathematics survey triggered researchers in Indonesia to develop PISA-like mathematics tasks. Some development studies have been conducted to produce valid and practical PISA-like problems that potentially effect on improving students’ mathematical literacy. This article describes the experiences of Indonesian task designers in developing PISA-like mathematics tasks as well as the potential future studies regarding to mathematical literacy as challenges for policy makers, researchers, and practitioners to improve students’ mathematical literacy in Indonesia. The results of this research indicate the task designers to consider domains of PISA like: context, mathematical content, and process as the first profiles of their missions. Our analysis shows that the designers mostly experienced difficulties regarding to the authenticity of context use and language structure. Interestingly, many of them used a variety of local wisdom in Indonesia as contexts for designing PISA-like tasks. In addition, the products developed were reported to be potentially effects on students’ interest and elicit students’ mathematical competencies as mentioned in PISA framework. Finally, this paper discusses future studies such as issues in bringing PISA task into an instructional practice.

Strengthening environmental foresight: potential contributions of futures research

Treesearch

David N. Bengston; George H. Kubik; Peter C. Bishop

2012-01-01

The need for environmental foresight has increased in recent decades as the pace of change has accelerated and the frequency of surprise has increased. Successfully dealing with the growing impacts of change on social-ecological systems depends on our ability to anticipate change. But traditional scientific tools are blunt instruments for studying a future that does...

Engaging communities and climate change futures with Multi-Scale, Iterative Scenario Building (MISB) in the western United States

Treesearch

Daniel Murphy; Carina Wyborn; Laurie Yung; Daniel R. Williams; Cory Cleveland; Lisa Eby; Solomon Dobrowski; Erin Towler

2016-01-01

Current projections of future climate change foretell potentially transformative ecological changes that threaten communities globally. Using two case studies from the United States Intermountain West, this article highlights the ways in which a better articulation between theory and methods in research design can generate proactive applied tools that enable...

Teacher Attrition and Retention Research in Australia: Towards a New Theoretical Framework

ERIC Educational Resources Information Center

Mason, Shannon; Matas, Cristina Poyatos

2015-01-01

During the last decades, the search to try to understand why Australian teachers prematurely leave their jobs has become an increasing focus of research interest. This article yields significant insights into the history and potential future of the teacher attrition research field. Using a thematic content analysis methodology, a study of the…

A social-ecological analysis of the self-determination literature.

PubMed

Shogren, Karrie A

2013-12-01

This paper uses a social-ecological lens to examine self-determination research, attempting to organize what is known (and unknown) about contextual factors that have the potential to impact the development and expression of self-determined behavior in people with disabilities across multiple ecological systems. Identifying and categorizing the contextual factors that researchers suggest influence self-determination have the potential to allow for the development of a framework that promotes systematic consideration of contextual factors when designing, implementing, and evaluating supports to promote self-determination. Directions for future research and practice are discussed.

News media reporting on civil litigation and its influence on civil justice decision making.

PubMed

Robbennolt, Jennifer K; Studebaker, Christina A

2003-02-01

The news media have the potential to act as a powerful influence on the civil litigation system, influencing decision making in particular cases and on the system more generally as media reports influence the decision making of various participants in the system. This paper reviews the research that has examined the relationship between news media reporting and civil litigation and proposes a framework that integrates this work and provides guidance for future research efforts. Specifically, we discuss the nature of media reporting on civil litigation, perceptions of the civil litigation system held by the public and legal actors, and the potential influence of news reporting about civil litigation on the decision making of jurors, judges, civil litigants, and policymakers. Overall, the research suggests that news reporting of civil litigation presents a systematically distorted picture of civil litigation and that this reporting can influence perceptions and outcomes of civil litigation in various ways. However, there are many gaps in the existing research that need to be filled. The proposed organizational scheme helps to identify ways that future research can provide links between the findings of existing research and to identify ways in which this research can be extended to new areas.

SCIENS: Opening Eyes to the Future.

ERIC Educational Resources Information Center

Landgren, C. R.

1988-01-01

SCIENS is a Middlebury College (Vermont) program designed to excite minority student interest in the natural sciences and to provide students with training and research experiences. The program, encompassing three summers, involves core instruction for high-potential 11th-grade students, summer research in college laboratories, and internships in…

Joint Professional Military Education: Opportunities Exist for Greater Oversight and Coordination of Associated Research Institutions

DTIC Science & Technology

2014-03-01

research requests across the department exposes DOD to the risk of potential overlap of studies and analysis research. View GAO-14-216. For more...National Defense University GPRA Government Performance and Results Act CCO Center for Complex Operations CSR Center for Strategic...their future leadership positions. To provide broad educational experiences, students can conduct research at the JPME research institutions as part

Transient Receptor Potential channels: What's happening? Reflections in the wake of the 2009 TRP Meeting, Karolinska Institutet, Stockholm.

PubMed

Goswami, Chandan; Islam, Md Shahidul

2010-01-01

More than 150 participants from 25 countries gathered in Stockholm during 25(th) to 27(th) Sept 2009 to attend the meeting "TRP channels: from sensory signaling to human disease" and enjoyed an international, intensive and vibrant meeting. This meeting shed lights on the recent advances made in this field of research in different sectors of biology, and identified directions for future research and the areas where TRP channels could be used as potential targets for prevention and treatment of human diseases. The participants of this meeting shared their recent largely unpublished data, state-of-the-art techniques and their critical views which would push research in this field forward in the new decade. Another major outcome of this meeting was the realization that extensive work remains to be done to develop the necessary tools and enhance the quality of research in this area so that the prevailing controversies can be resolved. In this report we summarize the latest scientific excitements, some critical issues, as well as some future directions for research that were addressed and discussed in this meeting.

Methane Hydrate Field Program. Development of a Scientific Plan for a Methane Hydrate-Focused Marine Drilling, Logging and Coring Program

DOE Office of Scientific and Technical Information (OSTI.GOV)

Collett, Tim; Bahk, Jang-Jun; Frye, Matt

2013-12-31

This topical report represents a pathway toward better understanding of the impact of marine methane hydrates on safety and seafloor stability and future collection of data that can be used by scientists, engineers, managers and planners to study climate change and to assess the feasibility of marine methane hydrate as a potential future energy resource. Our understanding of the occurrence, distribution and characteristics of marine methane hydrates is incomplete; therefore, research must continue to expand if methane hydrates are to be used as a future energy source. Exploring basins with methane hydrates has been occurring for over 30 years, butmore » these efforts have been episodic in nature. To further our understanding, these efforts must be more regular and employ new techniques to capture more data. This plan identifies incomplete areas of methane hydrate research and offers solutions by systematically reviewing known methane hydrate “Science Challenges” and linking them with “Technical Challenges” and potential field program locations.« less

On the Predictability of Future Impact in Science

PubMed Central

Penner, Orion; Pan, Raj K.; Petersen, Alexander M.; Kaski, Kimmo; Fortunato, Santo

2013-01-01

Correctly assessing a scientist's past research impact and potential for future impact is key in recruitment decisions and other evaluation processes. While a candidate's future impact is the main concern for these decisions, most measures only quantify the impact of previous work. Recently, it has been argued that linear regression models are capable of predicting a scientist's future impact. By applying that future impact model to 762 careers drawn from three disciplines: physics, biology, and mathematics, we identify a number of subtle, but critical, flaws in current models. Specifically, cumulative non-decreasing measures like the h-index contain intrinsic autocorrelation, resulting in significant overestimation of their “predictive power”. Moreover, the predictive power of these models depend heavily upon scientists' career age, producing least accurate estimates for young researchers. Our results place in doubt the suitability of such models, and indicate further investigation is required before they can be used in recruiting decisions. PMID:24165898

Future forum, Hobart, October 29, 2017: examining the role of medical physics in cancer research.

PubMed

Ebert, Martin A; Hardcastle, Nicholas; Kron, Tomas

2018-06-25

This commentary reports on a forum held in October 2017 in Hobart, Tasmania, attended by 20 Australasian medical physicists, to consider the future role of medical physics, as well as non-medical physics and allied disciplines, in oncology research. Attendees identified important areas of oncology research which physicists can be contributing to, with these evaluated in the context of a set of "Provocative Questions" recently generated by the American Association of Physicists in Medicine. Primary perceived barriers to participation in research were identified, including a "lack of knowledge of cancer science", together with potential solutions. Mechanisms were considered for engagement with the broader scientific community, consumers, advocates and policy makers. In considering future opportunities in oncology research for medical physicists, it was noted that a professional need to focus on the safety and accuracy of current treatments applied to patients, encouraging risk-aversion, is somewhat in competition with the role of physical scientists in the exploration and discovery of new concepts and understandings.

Recent advances and future directions in mantle cell lymphoma research: report of the 2016 mantle cell lymphoma consortium workshop.

PubMed

Kahl, Brad S; Dreyling, Martin; Gordon, Leo I; Quintanilla-Martinez, Leticia; Sotomayor, Eduardo M

2017-07-01

Mantle cell lymphoma (MCL) is an aggressive B-cell non-Hodgkin lymphoma typically associated with the t(11;14) chromosomal translocation, resulting in overexpression of cyclin D1. Although MCL is associated with clinical heterogeneity, outcomes are generally poor and no standard treatment has been established. However, the recent approval of ibrutinib provides a new therapeutic option. Moreover, recent clinical trials have provided new perspectives on the relative efficacy and safety of various approaches for both transplant-eligible and transplant-ineligible patients. Multiple novel strategies are being evaluated in the treatment of MCL, including both targeted agents and cellular immunotherapies. At the Lymphoma Research Foundation's 12th MCL Workshop, researchers gathered to discuss research findings, clinical trial results, and future directions related to MCL, its biology, and its treatment. This manuscript, which includes a summary of each presentation, aims to review recent findings in MCL research and highlight potential areas for future study.

NASA Satellite Observations: A Unique Asset for the Study of the Environment and Implications for Public

NASA Technical Reports Server (NTRS)

Estes, Sue

2010-01-01

Health providers/researchers need environmental data to study and understand the geographic, environmental, and meteorological differences in disease. Satellite remote sensing of the environment offers a unique vantage point that can fill in the gaps of environmental, spatial, and temporal data for tracking disease. The field of geospatial health remains in its infancy, and this program will demonstrate the need for collaborations between multi-disciplinary research groups to develop the full potential. NASA will discuss some of their Public Health Projects and also providing the audience with information on opportunities for future collaborations with NASA for future research.

Development of a public health nursing data infrastructure.

PubMed

Monsen, Karen A; Bekemeier, Betty; P Newhouse, Robin; Scutchfield, F Douglas

2012-01-01

An invited group of national public health nursing (PHN) scholars, practitioners, policymakers, and other stakeholders met in October 2010 identifying a critical need for a national PHN data infrastructure to support PHN research. This article summarizes the strengths, limitations, and gaps specific to PHN data and proposes a research agenda for development of a PHN data infrastructure. Future implications are suggested, such as issues related to the development of the proposed PHN data infrastructure and future research possibilities enabled by the infrastructure. Such a data infrastructure has potential to improve accountability and measurement, to demonstrate the value of PHN services, and to improve population health. © 2012 Wiley Periodicals, Inc.

Polycystic ovary syndrome and adverse pregnancy outcomes: Current state of knowledge, challenges and potential implications for practice.

PubMed

Bahri Khomami, Mahnaz; Boyle, Jacqueline A; Tay, Chau T; Vanky, Eszter; Teede, Helena J; Joham, Anju E; Moran, Lisa J

2018-06-01

Although there is a growing body of literature reporting that pregnancies in women with polycystic ovary syndrome (PCOS) are associated with greater complications than those without PCOS, methodological differences across studies make these results difficult to consolidate. This narrative review outlines potential mechanisms involved in adverse pregnancy outcomes in PCOS and the nature of the complications. It covers limitations of current evidence and future research directions. Future research should include prospective studies with phenotypic stratification of PCOS and matching or consideration of specific PCOS manifestations and risk factors specific to each pregnancy complication. This review also emphasizes the importance of following a healthy lifestyle for women with PCOS and of individualized care according to overall risk factors for pregnancy complications. © 2018 John Wiley & Sons Ltd.

Conflict and Consensus in Teacher Candidates' Discussion of Ethnic Autobiography.

ERIC Educational Resources Information Center

Florio-Ruane, Susan; deTar, Julie

A Future Teachers' Autobiography Club discussion group/research project invited six elementary teacher candidates to read, write about, and discuss ethnic autobiography in order to foster and investigate the potential of peer discussion in teacher learning. Using a selected list of six autobiographies, the researcher hosted monthly dinner…

Next Stage for Testing Envisioned

ERIC Educational Resources Information Center

Sparks, Sarah D.

2013-01-01

Emerging technology and research on learning have the potential to dramatically improve assessments, if educators and policymakers take a more balanced approach to using them. That's the conclusion of two years of analysis by the Gordon Commission on the Future of Assessment in Education, a panel of top education research and policy experts that…

Potential climate change impacts on fire weather in the United States

Treesearch

Warren E. Heilman; Ying Tang; Lifeng Luo; Shiyuan Zhong; Julie Winkler; Xindi. Bian

2015-01-01

Researchers at Michigan State University and the Forest Service's Northern Research Station worked on a joint study to examine the possible effects of future global and regional climate change on the occurrence of fire-weather patterns often associated with extreme and erratic wildfire behavior in the United States.

Leaving a Community College Presidency: The Inevitable Career Transition

ERIC Educational Resources Information Center

Floyd, Deborah L.; Maslin-Ostrowski, Patricia

2013-01-01

This article provides a succinct synthesis of research about community college presidents who have experienced a crisis or dilemma as leaders and focuses on issues surrounding a sudden and unplanned departure. In addition to describing themes, the authors present implications for leaders and potential areas for future research.

A Primer on Audience Response Systems: Current Applications and Future Considerations

PubMed Central

Robinson, Evan

2008-01-01

Audience response systems (ARSs) are an increasingly popular tool in higher education for promoting interactivity, gathering feedback, preassessing knowledge, and assessing students' understanding of lecture concepts. Instructors in numerous disciplines are realizing the pedagogical value of these systems. Actual research on ARS usage within pharmacy education is sparse. In this paper, the health professions literature on uses of ARSs is reviewed and a primer on the issues, benefits, and potential uses within pharmacy education is presented. Future areas of educational research on ARS instructional strategies are also suggested. PMID:19002277

Technology assessment of future intercity passenger transportation systems. Volume 7: Study recommendations

NASA Technical Reports Server (NTRS)

1976-01-01

Research and analysis tasks to alleviate negative impacts, to augment positive impacts, or to better understand the impacts produced by the potential introduction of the alternate transportation technologies are identified. The project team's recommendations on research and analysis efforts which have resulted from the technology assessment are provided. Many of the recommendations apply to the future supply of intercity passenger transportation services, categorized by mode. Other recommendations pertain to broad issues in intercity transportation--e.g., finance, regulation, traveler values--that will affect all modes.

Future perspectives of resin-based dental materials.

PubMed

Jandt, Klaus D; Sigusch, Bernd W

2009-08-01

This concise review and outlook paper gives a view of selected potential future developments in the area of resin-based biomaterials with an emphasis on dental composites. A selection of key publications (1 book, 35 scientific original publications and 1 website source) covering the areas nanotechnology, antimicrobial materials, stimuli responsive materials, self-repairing materials and materials for tissue engineering with direct or indirect relations and/or implications to resin-based dental materials is critically reviewed and discussed. Connections between these fields and their potential for resin-based dental materials are highlighted and put in perspective. The need to improve shrinkage properties and wear resistance is obvious for dental composites, and a vast number of attempts have been made to accomplish these aims. Future resin-based materials may be further improved in this respect if, for example nanotechnology is applied. Dental composites may, however, reach a completely new quality by utilizing new trends from materials science, such as introducing nanostructures, antimicrobial properties, stimuli responsive capabilities, the ability to promote tissue regeneration or repair of dental tissues if the composites were able to repair themselves. This paper shows selected potential future developments in the area of resin-based dental materials, gives basic and industrial researchers in dental materials science, and dental practitioners a glance into the potential future of these materials, and should stimulate discussion about needs and future developments in the area.

Qualitative Future Safety Risk Identification an Update

NASA Technical Reports Server (NTRS)

Barr, Lawrence C.

2017-01-01

The purpose of this report is to document the results of a high-level qualitative study that was conducted to identify future aviation safety risks and to assess the potential impacts to the National Airspace System (NAS) of NASA Aviation Safety research on these risks. Multiple external sources (for example, the National Transportation Safety Board, the Flight Safety Foundation, the National Research Council, and the Joint Planning and Development Office) were used to develop a compilation of future safety issues risks, also referred to as future tall poles. The primary criterion used to identify the most critical future safety risk issues was that the issue must be cited in several of these sources as a safety area of concern. The tall poles in future safety risk, in no particular order of importance, are as follows: Runway Safety, Loss of Control In Flight, Icing Ice Detection, Loss of Separation, Near Midair Collision Human Fatigue, Increasing Complexity and Reliance on Automation, Vulnerability Discovery, Data Sharing and Dissemination, and Enhanced Survivability in the Event of an Accident.

The role of the research simulator in the systems development of rotorcraft

NASA Technical Reports Server (NTRS)

Statler, I. C.; Deel, A.

1981-01-01

The potential application of the research simulator to future rotorcraft systems design, development, product improvement evaluations, and safety analysis is examined. Current simulation capabilities for fixed-wing aircraft are reviewed and the requirements of a rotorcraft simulator are defined. The visual system components, vertical motion simulator, cab, and computation system for a research simulator under development are described.

Recent and future climate suitability for whitebark pine mortality from mountain pine beetles varies across the western US

Treesearch

Polly C. Buotte; Jeffrey A. Hicke; Haiganoush K. Preisler; John T. Abatzoglou; Kenneth F. Raffa; Jesse A. Logan

2017-01-01

Recent mountain pine beetle outbreaks in whitebark pine forests have been extensive and severe. Understanding the climate influences on these outbreaks is essential for developing management plans that account for potential future mountain pine beetle outbreaks, among other threats, and informing listing decisions under the Endangered Species Act. Prior research has...

Forest landscape mosaics: Disturbance, restoration, and management at times of global change

Treesearch

Kalev Jogiste; Bengt Gunnar Jonsson; Timo Kuuluvainen; Sylvie Gauthier; W. Keith Moser

2015-01-01

Potential effects of hypothesized anthropogenic climate change are raising concerns about the sustainability of development in terms of both people and the rest of the environment. Land use change at the global scale presents many challenges for the research community. Past land use has a definite effect on future ecosystems, but it is challenging to predict future...

Research perspectives in first metatarsal osteotomy and fixation stability.

PubMed

Landsman, A S; Higgins, K R; Lampe, N

1996-07-01

Well-designated research is required to provide clinical guidance by validation of old and new methods. Variables, including technologic advancement in surgical techniques, diagnosis, shoe design, and immobilization all contribute to the challenge of investigating surgical procedures of the foot. This article highlights some of the relevant research pertaining to first metatarsal osteotomies and internal fixation and provides direction for potential, future research. Numerous aspects about the research techniques involved are discussed.

Community-level climate change vulnerability research: trends, progress, and future directions

NASA Astrophysics Data System (ADS)

McDowell, Graham; Ford, James; Jones, Julie

2016-03-01

This study systematically identifies, characterizes, and critically evaluates community-level climate change vulnerability assessments published over the last 25 years (n = 274). We find that while the field has advanced considerably in terms of conceptual framing and methodological approaches, key shortcomings remain in how vulnerability is being studied at the community-level. We argue that vulnerability research needs to more critically engage with the following: methods for evaluating future vulnerability, the relevance of vulnerability research for decision-making, interdependencies between social and ecological systems, attention to researcher / subject power dynamics, critical interpretation of key terms, and consideration of the potentially positive opportunities presented by a changing climate. Addressing these research needs is necessary for generating knowledge that supports climate-affected communities in navigating the challenges and opportunities ahead.

Potential applications of biosurfactant rhamnolipids in agriculture and biomedicine.

PubMed

Chen, Jianwei; Wu, Qihao; Hua, Yi; Chen, Jun; Zhang, Huawei; Wang, Hong

2017-12-01

Rhamnolipids have recently emerged as promising bioactive molecules due to their novel structures, diverse and versatile biological functions, lower toxicity, higher biodegradability, as well as production from renewable resources. The advantages of rhamnolipids make them attractive targets for research in a wide variety of applications. Especially rhamnolipids are likely to possess potential applications of the future in areas such as biomedicine, therapeutics, and agriculture. The purpose of this mini review is to provide a comprehensive prospective of biosurfactant rhamnolipids as potential antimicrobials, immune modulators, and virulence factors, and anticancer agents in the field of biomedicine and agriculture that may meet the ever-increasing future pharmacological treatment and food safety needs in human health.

Considerations and Future Research Directions for E-Cigarette Warnings-Findings from Expert Interviews.

PubMed

Wackowski, Olivia A; Hammond, David; O'Connor, Richard J; Strasser, Andrew A; Delnevo, Cristine D

2017-07-14

Tobacco warning labels are important sources of risk information but research historically has been cigarette-centric. This qualitative study aimed to inform future direction and research on warnings for e-cigarettes. Between June and August 2016, we conducted interviews with 10 researchers with expertise in tobacco warning label research. Interviewees were registrants of a 2016 National Cancer Institute grantee meeting on tobacco warnings. Several participants agreed that the Food and Drug Administration's new nicotine addiction warning for e-cigarettes could be informative but that it might not resonate with young people. Many agreed that more than one warning would be important as e-cigarette science evolves and that research on additional warning themes (e.g., nicotine exposure, harmful constituents) and execution styles (including use of pictorials) was important. Participants were somewhat mixed about the use of reduced-risk messages within e-cigarette warnings, but agreed that research on how to communicate about cigarette/e-cigarette relative risks was needed. Overall, more research is needed on tobacco warnings for non-cigarette products, including on the message content, placement, execution and potential impact on audiences' product knowledge, risk perceptions and use intentions. This is particularly needed for products such as e-cigarettes which may have harm-reduction potential relative to cigarettes and require unique considerations.

Considerations and Future Research Directions for E-Cigarette Warnings—Findings from Expert Interviews

PubMed Central

Wackowski, Olivia A.; Hammond, David; O’Connor, Richard J.; Strasser, Andrew A.; Delnevo, Cristine D.

2017-01-01

Tobacco warning labels are important sources of risk information but research historically has been cigarette-centric. This qualitative study aimed to inform future direction and research on warnings for e-cigarettes. Between June and August 2016, we conducted interviews with 10 researchers with expertise in tobacco warning label research. Interviewees were registrants of a 2016 National Cancer Institute grantee meeting on tobacco warnings. Several participants agreed that the Food and Drug Administration’s new nicotine addiction warning for e-cigarettes could be informative but that it might not resonate with young people. Many agreed that more than one warning would be important as e-cigarette science evolves and that research on additional warning themes (e.g., nicotine exposure, harmful constituents) and execution styles (including use of pictorials) was important. Participants were somewhat mixed about the use of reduced-risk messages within e-cigarette warnings, but agreed that research on how to communicate about cigarette/e-cigarette relative risks was needed. Overall, more research is needed on tobacco warnings for non-cigarette products, including on the message content, placement, execution and potential impact on audiences’ product knowledge, risk perceptions and use intentions. This is particularly needed for products such as e-cigarettes which may have harm-reduction potential relative to cigarettes and require unique considerations. PMID:28708124

Assessment of Alternative Aircraft Fuels

NASA Technical Reports Server (NTRS)

1984-01-01

The purpose of this symposium is to provide representatives from industry, government, and academia concerned with the availability and quality of future aviation turbine fuels with recent technical results and a status review of DOD and NASA sponsored fuels research projects. The symposium has included presentations on the potential crude sources, refining methods, and characteristics of future fuels; the effects of changing fuel characteristics on the performance and durability of jet aircraft components and systems; and the prospects for evolving suitable technology to produce and use future fuels.

Energy Options for the Future

NASA Astrophysics Data System (ADS)

Sheffield, John; Obenschain, Stephen; Conover, David; Bajura, Rita; Greene, David; Brown, Marilyn; Boes, Eldon; McCarthy, Kathyrn; Christian, David; Dean, Stephen; Kulcinski, Gerald; Denholm, P. L.

2004-06-01

This paper summarizes the presentations and discussion at the Energy Options for the Future meeting held at the Naval Research Laboratory in March of 2004. The presentations covered the present status and future potential for coal, oil, natural gas, nuclear, wind, solar, geothermal, and biomass energy sources and the effect of measures for energy conservation. The longevity of current major energy sources, means for resolving or mitigating environmental issues, and the role to be played by yet to be deployed sources, like fusion, were major topics of presentation and discussion.

Gilbert W. Beebe Symposium on 30 Years after the Chernobyl Accident: Current and Future Studies on Radiation Health Effects.

PubMed

Samet, Jonathan M; de González, Amy Berrington; Dauer, Lawrence T; Hatch, Maureen; Kosti, Ourania; Mettler, Fred A; Satyamitra, Merriline M

2018-01-01

This commentary summarizes the presentations and discussions from the 2016 Gilbert W. Beebe symposium "30 years after the Chernobyl accident: Current and future studies on radiation health effects." The symposium was hosted by the National Academies of Sciences, Engineering, and Medicine (the National Academies). The symposium focused on the health consequences of the Chernobyl accident, looking retrospectively at what has been learned and prospectively at potential future discoveries using emerging 21st Century research methodologies.

Transdisciplinary translational behavioral (TDTB) research: opportunities, barriers, and innovations.

PubMed

Czajkowski, Susan M; Lynch, Minda R; Hall, Kara L; Stipelman, Brooke A; Haverkos, Lynne; Perl, Harold; Scott, Marcia S; Shirley, Mariela C

2016-03-01

The translation of basic behavioral science discoveries into practical strategies represents a promising approach to developing more effective preventive interventions to improve health. Since translational research inevitably involves making use of diverse perspectives from multiple disciplines, it is best conducted as a transdisciplinary enterprise. In this paper, we discuss current strategies used by NIH to support transdisciplinary translational behavioral (TDTB) research, summarize successful efforts, and highlight challenges encountered in conducting such work (ranging from conceptual to organizational to methodological). Using examples from NIH-funded projects we illustrate the potential benefits of, and barriers to, pursuing this type of research and discuss next steps and potential future directions for NIH-supported TDTB research.

Subliminal Priming-State of the Art and Future Perspectives.

PubMed

Elgendi, Mohamed; Kumar, Parmod; Barbic, Skye; Howard, Newton; Abbott, Derek; Cichocki, Andrzej

2018-05-30

The influence of subliminal priming (behavior outside of awareness) in humans is an interesting phenomenon and its understanding is crucial as it can impact behavior, choices, and actions. Given this, research about the impact of priming continues to be an area of investigative interest, and this paper provides a technical overview of research design strengths and issues in subliminal priming research. Efficient experiments and protocols, as well as associated electroencephalographic and eye movement data analyses, are discussed in detail. We highlight the strengths and weaknesses of different priming experiments that have measured affective (emotional) and cognitive responses. Finally, very recent approaches and findings are described to summarize and emphasize state-of-the-art methods and potential future directions in research marketing and other commercial applications.

A Future with Hybrid Electric Propulsion Systems: A NASA Perspective

NASA Technical Reports Server (NTRS)

DelRosario, Ruben

2014-01-01

The presentation highlights a NASA perspective on Hybrid Electric Propulsion Systems for aeronautical applications. Discussed are results from NASA Advance Concepts Study for Aircraft Entering service in 2030 and beyond and the potential use of hybrid electric propulsion systems as a potential solution to the requirements for energy efficiency and environmental compatibility. Current progress and notional potential NASA research plans are presented.

Students' Research-Informed Socio-Scientific Activism: Re/Visions for a Sustainable Future

ERIC Educational Resources Information Center

Bencze, Larry; Sperling, Erin; Carter, Lyn

2012-01-01

In many educational contexts throughout the world, increasing focus has been placed on "socio-scientific issues"; that is, disagreements about potential personal, social and/or environmental problems associated with fields of science and technology. Some suggest (as do we) that many of these potential problems, such as those associated with…

Placing the power of real options analysis into the hands of natural resource managers - taking the next step.

PubMed

Nelson, Rohan; Howden, Mark; Hayman, Peter

2013-07-30

This paper explores heuristic methods with potential to place the analytical power of real options analysis into the hands of natural resource managers. The complexity of real options analysis has led to patchy or ephemeral adoption even by corporate managers familiar with the financial-market origins of valuation methods. Intuitively accessible methods for estimating the value of real options have begun to evolve, but their evaluation has mostly been limited to researcher-driven applications. In this paper we work closely with Bush Heritage Australia to evaluate the potential of real options analysis to support the intuitive judgement of conservation estate managers in covenanting land with uncertain future conservation value due to climate change. The results show that modified decision trees have potential to estimate the option value of covenanting individual properties while time and ongoing research resolves their future conservation value. Complementing this, Luehrman's option space has potential to assist managers with limited budgets to increase the portfolio value of multiple properties with different conservation attributes. Copyright © 2013 Elsevier Ltd. All rights reserved.

Prospective Longitudinal Studies of Infant Siblings of Children With Autism: Lessons Learned and Future Directions.

PubMed

Szatmari, Peter; Chawarska, Katarzyna; Dawson, Geraldine; Georgiades, Stelios; Landa, Rebecca; Lord, Catherine; Messinger, Daniel S; Thurm, Audrey; Halladay, Alycia

2016-03-01

The objectives of this review are to highlight the impact of the first decade of high-risk (HR) infant sibling work in autism spectrum disorder (ASD) and to identify potential areas of translational focus for the next decade of research. A group of clinicians and researchers in ASD working both inside and outside of the HR design met on a regular basis to review the infant sibling research, and came to an agreement on areas that had changed clinical practice and areas that had the potential to change practice with further research. The group then outlined several methodological and translational challenges that must be addressed in the next decade of research if the field is to reach its potential. The review concluded that the HR design has yielded an understanding that ASD often, but not always, begins to emerge between 6 and 18 months, with early signs affecting social communication. Research using the HR design has also allowed a better understanding of the sibling recurrence risk (between 10% and 20%). Emerging areas of interest include the developmental trajectories of social communications skills in the early years, the expression of a milder phenotype in siblings not affected with ASD, and the possibility that early intervention with infant siblings may improve outcomes for those with ASD. Important challenges for the future include linking screening to intervention, collecting large sample sizes while ensuring cross-site reliability, and building in capacity for replication. Although there are significant methodological and translational challenges for high-risk infant sibling research, the potential of this design to improve long-term outcomes of all children with ASD is substantial. Published by Elsevier Inc.

Prospective Longitudinal Studies of Infant Siblings of Children With Autism: Lessons Learned and Future Directions

PubMed Central

Szatmari, Peter; Chawarska, Katarzyna; Dawson, Geraldine; Georgiades, Stelios; Landa, Rebecca; Lord, Catherine; Messinger, Daniel S.; Thurm, Audrey; Halladay, Alycia

2016-01-01

Objective The objectives of this review are to highlight the impact of the first decade of high-risk (HR) infant sibling work in autism spectrum disorder (ASD) and to identify potential areas of translational focus for the next decade of research. Method A group of clinicians and researchers in ASD working both inside and outside of the HR design met on a regular basis to review the infant sibling research, and came to an agreement on areas that had changed clinical practice and areas that had the potential to change practice with further research. The group then outlined several methodological and translational challenges that must be addressed in the next decade of research if the field is to reach its potential. Results The review concluded that the HR design has yielded an understanding that ASD often, but not always, begins to emerge between 6 and 18 months, with early signs affecting social communication. Research using the HR design has also allowed a better understanding of the sibling recurrence risk (between 10% and 20%). Emerging areas of interest include the developmental trajectories of social communications skills in the early years, the expression of a milder phenotype in siblings not affected with ASD, and the possibility that early intervention with infant siblings may improve outcomes for those with ASD. Important challenges for the future include linking screening to intervention, collecting large sample sizes while ensuring cross-site reliability, and building in capacity for replication. Conclusion Although there are significant methodological and translational challenges for high-risk infant sibling research, the potential of this design to improve long-term outcomes of all children with ASD is substantial. PMID:26903251

Natural disasters: Cities build their vulnerability

NASA Astrophysics Data System (ADS)

Jones, Bryan

2017-04-01

Tornadoes pose a significant threat across vast portions of the US. Now research suggests that growth in the human-built environment will be more influential than climate change in driving future disaster potential.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rios-Torres, Jackeline; Malikopoulos, Andreas A.

Connected and automated vehicles (CAVs) have the potential to improve safety by reducing and mitigating traffic accidents. They can also provide opportunities to reduce transportation energy consumption and emissions by improving traffic flow. Vehicle communication with traffic structures and traffic lights can allow individual vehicles to optimize their operation and account for unpredictable changes. This paper summarizes the developments and the research trends in coordination with the CAVs that have been reported in the literature to date. In conclusion, remaining challenges and potential future research directions are also discussed.

How can the research potential of the clinical quality databases be maximized? The Danish experience.

PubMed

Nørgaard, M; Johnsen, S P

2016-02-01

In Denmark, the need for monitoring of clinical quality and patient safety with feedback to the clinical, administrative and political systems has resulted in the establishment of a network of more than 60 publicly financed nationwide clinical quality databases. Although primarily devoted to monitoring and improving quality of care, the potential of these databases as data sources in clinical research is increasingly being recognized. In this review, we describe these databases focusing on their use as data sources for clinical research, including their strengths and weaknesses as well as future concerns and opportunities. The research potential of the clinical quality databases is substantial but has so far only been explored to a limited extent. Efforts related to technical, legal and financial challenges are needed in order to take full advantage of this potential. © 2016 The Association for the Publication of the Journal of Internal Medicine.

[Progress on neuropsychology and event-related potentials in patients with brain trauma].

PubMed

Dong, Ri-xia; Cai, Wei-xiong; Tang, Tao; Huang, Fu-yin

2010-02-01

With the development of information technology, as one of the research frontiers in neurophysiology, event-related potentials (ERP) is concerned increasingly by international scholars, which provides a feasible and objective method for exploring cognitive function. There are many advances in neuropsychology due to new assessment tool for the last years. The basic theories in the field of ERP and neuropsychology were reviewed in this article. The research and development in evaluating cognitive function of patients with syndrome after brain trauma were focused in this review, and the perspectives for the future research of ERP was also explored.

What about Place? Considering the Role of Physical Environment on Youth Imagining of Future Possible Selves.

PubMed

Prince, Dana

2014-07-01

Identity research indicates that development of well elaborated cognitions about oneself in the future, or one's possible selves, is consequential for youths' developmental trajectories, influencing a range of social, health, and educational outcomes. Although the theory of possible selves considers the role of social contexts in identity development, the potential influence of the physical environment is understudied. At the same time, a growing body of work spanning multiple disciplines points to the salience of place , or the meaningful physical environments of people's everyday lives, as an active contributor to self-identity. Bridging these two lines of inquiry, I provide evidence to show how place-based experiences, such as belonging, aversion, and entrapment, may be internalized and encoded into possible selves, thus producing emplaced future self-concept. I suggest that for young people, visioning self in the future is inextricably bound with place; place is an active contributor both in the present development of future self-concept and in enabling young people to envision different future possible places. Implications for practice and future research include place-making interventions and conceptualizing place beyond "neighborhood effects."

Historical growth plots in the Pacific Southwest

Treesearch

Lawrence A. Rabin; William W. Oliver; Robert F. Powers; Martin W. Ritchie; Matt D. Busse; Eric E. Knapp

2009-01-01

In the past, researchers from the Pacific Southwest Research Station (PSW) undertook forest growth studies to evaluate how best to manage timber resources. However, historical and future data collected at PSW growth plots also have the potential to increase our understanding of the ecological processes occurring in our forests and shed light on national issues of...

Lightweight Materials for Vehicles: Needs, Goals, and Future Technologies

DTIC Science & Technology

2010-08-01

during heating, cooling, and deformation - Developing an improved understanding of the kinetics and mechanisms for tranisition Friction Stir Welding ...technology worthiness - Identify new gaps and opportunities Pre- competitive Research Solicitations and Demonstrations - Identify technology gaps...or processing . Key Technology Gaps Active Research . Gap: Microstructural damage during welding limits potential usefulness - Many

Applying Cognitive Neuroscience Research to Education: The Case of Literacy

ERIC Educational Resources Information Center

Katzir, Tami; Pare-Blagoev, Juliana

2006-01-01

Neuroscience has provided fascinating glimpses into the brain's development and function. Despite remarkable progress, brain research has not yet been successfully brought to bear in many fields of educational psychology. In this article, work on literacy serves as a test case for an examination of potential future bridges linking mind, brain, and…

Affordances of Augmented Reality in Science Learning: Suggestions for Future Research

ERIC Educational Resources Information Center

Cheng, Kun-Hung; Tsai, Chin-Chung

2013-01-01

Augmented reality (AR) is currently considered as having potential for pedagogical applications. However, in science education, research regarding AR-aided learning is in its infancy. To understand how AR could help science learning, this review paper firstly has identified two major approaches of utilizing AR technology in science education,…

NREL Fuels and Engines Research: Maximizing Vehicle Efficiency and

Science.gov Websites

Laboratory, we analyze the effects of fuel chemistry on ignition and the potential emissions impacts. Our lab research. It can be used to investigate fuel chemistry effects on current and near-term engine technology , independent control allows for deeper interrogation of fuel effects on future-generation engine strategies

Higher Education Change and Social Networks: A Review of Research

ERIC Educational Resources Information Center

Kezar, Adrianna

2014-01-01

This article reviews literature on the potential for understanding higher education change processes through social network analysis (SNA). In this article, the main tenets of SNA are reviewed and, in conjunction with organizational theory, are applied to higher education change to develop a set of hypotheses that can be tested in future research.

Enhancing Elementary-School Mathematics Teachers' Efficacy Beliefs: A Qualitative Action Research

ERIC Educational Resources Information Center

Katz, Sara; Stupel, Moshe

2016-01-01

Individuals and societies that can use mathematics effectively in this period of rapid changes will have a voice on increasing the opportunities and potentials which can shape their future. This has brought affective characteristics, such as self-efficacy, that affect mathematics achievement into focus of the research. Teacher efficacy refers to…

Online Technology and Counseling Microskill Development: A Mixed-Methods Approach

ERIC Educational Resources Information Center

Nelson, J. Scott

2013-01-01

Emergent popularity and student consumer/educational administrator demand for online technology in counselor education is also increasing the need to research its impact and potential effectiveness/ineffectiveness as a pedagogical tool. Research shows that the trend toward online coursework is likely to increase in the future and also that the new…

A Bright Promise but a Dim Future. Researchers Examine Potential of Educational Technology.

ERIC Educational Resources Information Center

Pitts, Marcella R., Ed.

Concerns about the current educational technology movement are discussed in these four papers which were presented during a seminar of 20 representatives from 10 Council for Educational Development and Research (CEDaR) member institutions. The first by Marcella Pitts and E. Joseph Schneider provides an overview of the educational technology…

Human factors measurement for future air traffic control systems.

PubMed

Langan-Fox, Janice; Sankey, Michael J; Canty, James M

2009-10-01

This article provides a critical review of research pertaining to the measurement of human factors (HF) issues in current and future air traffic control (ATC). Growing worldwide air traffic demands call for a radical departure from current ATC systems. Future systems will have a fundamental impact on the roles and responsibilities of ATC officers (ATCOs). Valid and reliable methods of assessing HF issues associated with these changes, such as a potential increase (or decrease) in workload, are of utmost importance for advancing theory and for designing systems, procedures, and training. We outline major aviation changes and how these relate to five key HF issues in ATC. Measures are outlined, compared, and evaluated and are followed by guidelines for assessing these issues in the ATC domain. Recommendations for future research are presented. A review of the literature suggests that situational awareness and workload have been widely researched and assessed using a variety of measures, but researchers have neglected the areas of trust, stress, and boredom. We make recommendations for use of particular measures and the construction of new measures. It is predicted that, given the changing role of ATCOs and profound future airspace requirements and configurations, issues of stress, trust, and boredom will become more significant. Researchers should develop and/or refine existing measures of all five key HF issues to assess their impact on ATCO performance. Furthermore, these issues should be considered in a holistic manner. The current article provides an evaluation of research and measures used in HF research on ATC that will aid research and ATC measurement.

Quantum technology past, present, future: quantum energetics (Conference Presentation)

NASA Astrophysics Data System (ADS)

Choi, Sang H.

2017-04-01

Since the development of quantum physics in the early part of the 1900s, this field of study has made remarkable contributions to our civilization. Some of these advances include lasers, light-emitting diodes (LED), sensors, spectroscopy, quantum dots, quantum gravity and quantum entanglements. In 1998, the NASA Langley Research Center established a quantum technology committee to monitor the progress in this area and initiated research to determine the potential of quantum technology for future NASA missions. The areas of interest in quantum technology at NASA included fundamental quantum-optics materials associated with quantum dots and quantum wells, device-oriented photonic crystals, smart optics, quantum conductors, quantum information and computing, teleportation theorem, and quantum energetics. A brief review of the work performed, the progress made in advancing these technologies, and the potential NASA applications of quantum technology will be presented.

Cell transformation assays for prediction of carcinogenic potential: state of the science and future research needs

PubMed Central

Creton, Stuart; Aardema, Marilyn J.; Carmichael, Paul L.; Harvey, James S.; Martin, Francis L.; Newbold, Robert F.; O’Donovan, Michael R.; Pant, Kamala; Poth, Albrecht; Sakai, Ayako; Sasaki, Kiyoshi; Scott, Andrew D.; Schechtman, Leonard M.; Shen, Rhine R.; Tanaka, Noriho; Yasaei, Hemad

2012-01-01

Cell transformation assays (CTAs) have long been proposed as in vitro methods for the identification of potential chemical carcinogens. Despite showing good correlation with rodent bioassay data, concerns over the subjective nature of using morphological criteria for identifying transformed cells and a lack of understanding of the mechanistic basis of the assays has limited their acceptance for regulatory purposes. However, recent drivers to find alternative carcinogenicity assessment methodologies, such as the Seventh Amendment to the EU Cosmetics Directive, have fuelled renewed interest in CTAs. Research is currently ongoing to improve the objectivity of the assays, reveal the underlying molecular changes leading to transformation and explore the use of novel cell types. The UK NC3Rs held an international workshop in November 2010 to review the current state of the art in this field and provide directions for future research. This paper outlines the key points highlighted at this meeting. PMID:21852270

A Comprehensive Tool for Exploring the Availability, Scalability and Growth Potential of Conventional and Renewable Energy Sources and Technologies

NASA Astrophysics Data System (ADS)

Jack-Scott, E.; Arnott, J. C.; Katzenberger, J.; Davis, S. J.; Delman, E.

2015-12-01

It has been a generational challenge to simultaneously meet the world's energy requirements, while remaining within the bounds of acceptable cost and environmental impact. To this end, substantial research has explored various energy futures on a global scale, leaving decision-makers and the public overwhelmed by information on energy options. In response, this interactive energy table was developed as a comprehensive resource through which users can explore the availability, scalability, and growth potentials of all energy technologies currently in use or development. Extensive research from peer-reviewed papers and reports was compiled and summarized, detailing technology costs, technical considerations, imminent breakthroughs, and obstacles to integration, as well as political, social, and environmental considerations. Energy technologies fall within categories of coal, oil, natural gas, nuclear, solar, wind, hydropower, ocean, geothermal and biomass. In addition to 360 expandable cells of cited data, the interactive table also features educational windows with background information on each energy technology. The table seeks not to advocate for specific energy futures, but to succinctly and accurately centralize peer-reviewed research and information in an interactive, accessible resource. With this tool, decision-makers, researchers and the public alike can explore various combinations of energy technologies and their quantitative and qualitative attributes that can satisfy the world's total primary energy supply (TPES) while making progress towards a near zero carbon future.

Priorities for future research into asthma diagnostic tools: A PAN-EU consensus exercise from the European asthma research innovation partnership (EARIP).

PubMed

Garcia-Marcos, L; Edwards, J; Kennington, E; Aurora, P; Baraldi, E; Carraro, S; Gappa, M; Louis, R; Moreno-Galdo, A; Peroni, D G; Pijnenburg, M; Priftis, K N; Sanchez-Solis, M; Schuster, A; Walker, S

2018-02-01

The diagnosis of asthma is currently based on clinical history, physical examination and lung function, and to date, there are no accurate objective tests either to confirm the diagnosis or to discriminate between different types of asthma. This consensus exercise reviews the state of the art in asthma diagnosis to identify opportunities for future investment based on the likelihood of their successful development, potential for widespread adoption and their perceived impact on asthma patients. Using a two-stage e-Delphi process and a summarizing workshop, a group of European asthma experts including health professionals, researchers, people with asthma and industry representatives ranked the potential impact of research investment in each technique or tool for asthma diagnosis and monitoring. After a systematic review of the literature, 21 statements were extracted and were subject of the two-stage Delphi process. Eleven statements were scored 3 or more and were further discussed and ranked in a face-to-face workshop. The three most important diagnostic/predictive tools ranked were as follows: "New biological markers of asthma (eg genomics, proteomics and metabolomics) as a tool for diagnosis and/or monitoring," "Prediction of future asthma in preschool children with reasonable accuracy" and "Tools to measure volatile organic compounds (VOCs) in exhaled breath." © 2018 John Wiley & Sons Ltd.

Phytochemistry of the carnivorous sundew genus Drosera (Droseraceae) - future perspectives and ethnopharmacological relevance.

PubMed

Egan, Paul A; van der Kooy, Frank

2013-10-01

Species of the carnivorous genus Drosera L. have long been a source of valuable natural products. The various phytochemicals characteristic of these species, particularly 1,4-naphthoquinones and flavonoids, have contributed to the diverse utilization of sundews in traditional medicine systems worldwide. A growing number of studies have sought to investigate the comparative phytochemistry of Drosera species for improved sources of pharmaceutically important compounds. The outcomes of these studies are here collated, with emergent trends discussed in detail. Important factors which affect production of secondary metabolites in plants are critically examined, such as environmental influences and in vitro culture, and recommendations subsequently presented based on this. Explicitly, the current review aims to i) present an updated, comprehensive listing of the phytochemical constituents of the genus (including quantitative data where available), ii) summarize important factors which may influence the production of phytopharmaceuticals in plants, and iii) recommend guidelines for future research based on the above, including improved standardization and quality control. We have also included a section discussing future perspectives of research on Drosera spp. based on three different research lines i) the potential to produce much needed lead compounds for treatment of tuberculosis, ii) the potential role of anthocyanins in nitrogen transport, and iii) research into 'Natural Deep Eutectic' solvents produced by Drosera spp. in the droplets or 'dew' employed to capture insect prey. Copyright © 2013 Verlag Helvetica Chimica Acta AG, Zürich.

Observations from Space: A Unique Vantage Point for the Study of the Environment and Possible Associations with Disease Occurrence

NASA Technical Reports Server (NTRS)

Estes, S.; Haynes, J.; Hamdan, M. Al; Estes, M.; Sprigg, W.

2009-01-01

Health providers/researchers need environmental data to study and understand the geographic, environmental, and meteorological differences in disease. Satellite remote sensing of the environment offers a unique vantage point that can fill in the gaps of environmental, spatial, and temporal data for tracking disease. The field of geospatial health remains in its infancy, and this program will demonstrate the need for collaborations between multi-disciplinary research groups to develop the full potential. NASA will discuss the Public Health Projects developed to work with Grantees and the CDC while providing them with information on opportunities for future collaborations with NASA for future research.

What is "neuromarketing"? A discussion and agenda for future research.

PubMed

Lee, Nick; Broderick, Amanda J; Chamberlain, Laura

2007-02-01

Recent years have seen advances in neuroimaging to such an extent that neuroscientists are able to directly study the frequency, location, and timing of neuronal activity to an unprecedented degree. However, marketing science has remained largely unaware of such advances and their huge potential. In fact, the application of neuroimaging to market research--what has come to be called "neuromarketing"--has caused considerable controversy within neuroscience circles in recent times. This paper is an attempt to widen the scope of neuromarketing beyond commercial brand and consumer behaviour applications, to include a wider conceptualisation of marketing science. Drawing from general neuroscience and neuroeconomics, neuromarketing as a field of study is defined, and some future research directions are suggested.

Air Force Systems Command Research Planning Guide (Research Objectives).

DTIC Science & Technology

1987-07-15

potential for producing alloys with superior properties. Titanium and Iron Aluminides - Basic research to identify approaches leading to the formation...performance of ni’.kel, aluminumr,, and titanium alloys and ceramics are required to provide future Air Force weapon systems components with structural...seriously block full exploitat,on. Aluminum and Titanium Alloys - Three generic families of Pylie-,7 alloys are being investigated for both alloy

Designs that Fly: What the History of Aeronautics Tells Us about the Future of Design-Based Research in Education

ERIC Educational Resources Information Center

O'Neill, D. Kevin

2012-01-01

For almost two decades, there has been growing interest in what design-based research (DBR) can contribute to both educational practice and theory. Since its introduction into the literature, this orientation to educational research has repeatedly been likened to aeronautical engineering as a way to clarify its nature and argue its potential. This…

Lab to farm: applying research on plant genetics and genomics to crop improvement.

PubMed

Ronald, Pamela C

2014-06-01

Over the last 300 years, plant science research has provided important knowledge and technologies for advancing the sustainability of agriculture. In this Essay, I describe how basic research advances have been translated into crop improvement, explore some lessons learned, and discuss the potential for current and future contribution of plant genetic improvement technologies to continue to enhance food security and agricultural sustainability.

Examining Extension's Capacity in Community Resource and Economic Development: Viewpoints of Extension Administrators on the Role of Community Resource and Economic Development in the Extension Portfolio

ERIC Educational Resources Information Center

Urbanowitz, Seth C.; Wilcox, Michael D., Jr.

2013-01-01

The survey-based research reported here offers insights on community, resource, and economic development (CRED) Extension programming at the national and regional level. The results present a national picture of CRED programming, research, and potential future programming opportunities that Extension could capitalize on. The research shows that…

Transportation Energy Futures Series. Potential for Energy Efficiency Improvement Beyond the Light-Duty-Vehicle Sector

DOE Office of Scientific and Technical Information (OSTI.GOV)

Vyas, A. D.; Patel, D. M.; Bertram, K. M.

2013-02-01

Considerable research has focused on energy efficiency and fuel substitution options for light-duty vehicles, while much less attention has been given to medium- and heavy-duty trucks, buses, aircraft, marine vessels, trains, pipeline, and off-road equipment. This report brings together the salient findings from an extensive review of literature on future energy efficiency options for these non-light-duty modes. Projected activity increases to 2050 are combined with forecasts of overall fuel efficiency improvement potential to estimate the future total petroleum and greenhouse gas (GHG) emissions relative to current levels. This is one of a series of reports produced as a result ofmore » the Transportation Energy Futures (TEF) project, a Department of Energy-sponsored multi-agency project initiated to pinpoint underexplored strategies for abating GHGs and reducing petroleum dependence related to transportation.« less

Transportation Energy Futures Series: Potential for Energy Efficiency Improvement Beyond the Light-Duty-Vehicle Sector

DOE Office of Scientific and Technical Information (OSTI.GOV)

Vyas, A. D.; Patel, D. M.; Bertram, K. M.

2013-03-01

Considerable research has focused on energy efficiency and fuel substitution options for light-duty vehicles, while much less attention has been given to medium- and heavy-duty trucks, buses, aircraft, marine vessels, trains, pipeline, and off-road equipment. This report brings together the salient findings from an extensive review of literature on future energy efficiency options for these non-light-duty modes. Projected activity increases to 2050 are combined with forecasts of overall fuel efficiency improvement potential to estimate the future total petroleum and greenhouse gas (GHG) emissions relative to current levels. This is one of a series of reports produced as a result ofmore » the Transportation Energy Futures (TEF) project, a Department of Energy-sponsored multi-agency project initiated to pinpoint underexplored strategies for abating GHGs and reducing petroleum dependence related to transportation.« less

Homodyne Phase-Shift-Keying Systems: Past Challenges and Future Opportunities

NASA Astrophysics Data System (ADS)

Kazovsky, Leonid G.; Kalogerakis, Georgios; Shaw, Wei-Tao

2006-12-01

Homodyne phase-shift-keying systems can achieve the best receiver sensitivity and the longest transmission distance among all optical communication systems. This paper reviews recent research efforts in the field and examines future possibilities that might lead toward potential practical use of these systems. Additionally, phase estimation techniques based on feed-forward phase recovery and digital delay-lock loop approaches are examined, simulated, and compared.

Collaborative engagement experiment

NASA Astrophysics Data System (ADS)

Mullens, Katherine; Troyer, Bradley; Wade, Robert; Skibba, Brian; Dunn, Michael

2006-05-01

Unmanned ground and air systems operating in collaboration have the potential to provide future Joint Forces a significant capability for operations in complex terrain. Collaborative Engagement Experiment (CEE) is a consolidation of separate Air Force, Army and Navy collaborative efforts within the Joint Robotics Program (JRP) to provide a picture of the future of unmanned warfare. The Air Force Research Laboratory (AFRL), Material and Manufacturing Directorate, Aerospace Expeditionary Force Division, Force Protection Branch (AFRL/MLQF), The Army Aviation and Missile Research, Development and Engineering Center (AMRDEC) Joint Technology Center (JTC)/Systems Integration Laboratory (SIL), and the Space and Naval Warfare Systems Center - San Diego (SSC San Diego) are conducting technical research and proof of principle experiments for an envisioned operational concept for extended range, three dimensional, collaborative operations between unmanned systems, with enhanced situational awareness for lethal operations in complex terrain. This paper describes the work by these organizations to date and outlines some of the plans for future work.

High temporal discounters overvalue immediate rewards rather than undervalue future rewards: an event-related brain potential study.

PubMed

Cherniawsky, Avital S; Holroyd, Clay B

2013-03-01

Impulsivity is characterized in part by heightened sensitivity to immediate relative to future rewards. Although previous research has suggested that "high discounters" in intertemporal choice tasks tend to prefer immediate over future rewards because they devalue the latter, it remains possible that they instead overvalue immediate rewards. To investigate this question, we recorded the reward positivity, a component of the event-related brain potential (ERP) associated with reward processing, with participants engaged in a task in which they received both immediate and future rewards and nonrewards. The participants also completed a temporal discounting task without ERP recording. We found that immediate but not future rewards elicited the reward positivity. High discounters also produced larger reward positivities to immediate rewards than did low discounters, indicating that high discounters relatively overvalued immediate rewards. These findings suggest that high discounters may be more motivated than low discounters to work for monetary rewards, irrespective of the time of arrival of the incentives.

Study on feasible technical potential of coal to electricity in china

NASA Astrophysics Data System (ADS)

Jia, Dexiang; Tan, Xiandong

2017-01-01

The control of bulk coal is one of the important work of air pollution control in China’s future. Existing research mainly focuses on the adaptability, economy, construction and renovation plan, and operation optimization of specific energy substitution utilization, and lacks the strategy research of long-term layout of energy substitution utilization in large area. This paper puts forward a technical potential prediction method of coal to electricity based on the thermal equivalent method, which is based on the characteristics of regional coal consumption, and combined with the trend of adaptability and economy of energy substitution utilization. Also, the paper calculates the comprehensive benefit of coal to electricity according to the varieties of energy consumption and pollutant emission level of unit energy consumption in China’s future. The research result shows that the development technical potential of coal to electricity in China is huge, about 1.8 trillion kWh, including distributed electric heating, heat pump and electric heating boiler, mainly located in North China, East China, and Northeast China. The implementation of coal to electricity has remarkable comprehensive benefits in energy conservation and emission reduction, and improvement of energy consumption safety level. Case study shows the rationality of the proposed method.

Research planning for the future of psychiatric diagnosis.

PubMed

Regier, D A; Kuhl, E A; Narrow, W E; Kupfer, D J

2012-10-01

More than 10 years prior to the anticipated 2013 publication of DSM-5, processes were set in motion to assess the research and clinical issues that would best inform future diagnostic classification of mental disorders. These efforts intended to identify the clinical and research needs within various populations, examine the current state of the science to determine the empirical evidence for improving criteria within and across disorders, and stimulate research in areas that could potentially provide evidence for change. In the second phase of the revision process, the American Psychiatric Institute for Research and Education (APIRE) recently completed the 5-year international series of 13 diagnostic conferences convened by APA/APIRE in collaboration with the World Health Organization and the National Institutes of Health (NIH), under a cooperative grant funded by the NIH. From these conferences, the DSM-5 Task Force and Work Groups have developed plans for potential revisions for DSM-5, including the incorporation of dimensional approaches within and across diagnostic groups to clarify heterogeneity, improve diagnostic validity, and enhance clinical case conceptualization. Use of dimensions for measurement-based care has been shown to be feasible in psychiatric and primary care settings and may inform monitoring of disorder threshold, severity, and treatment outcomes. The integration of dimensions with diagnostic categories represents an exciting and potentially transformative approach for DSM-5 to simultaneously address DSM-IV's clinical short-comings and create novel pathways for research in neurobiology, genetics, and psychiatric epidemiology. Copyright © 2011 Elsevier Masson SAS. All rights reserved.

Attitude of A Sample of Iranian Researchers toward The Future of Stem Cell Research.

PubMed

Lotfipanah, Mahdi; Azadeh, Fereydoon; Totonchi, Mehdi; Omani-Samani, Reza

2018-10-01

Stem cells that have unlimited proliferation potential as well as differentiation potency are considered to be a promising future treatment method for incurable diseases. The aim of the present study is to evaluate the future trend of stem cell researches from researchers' viewpoints. This was a cross-sectional descriptive study on researchers involved in stem cell research at Royan Institute. We designed a questionnaire using a qualitative study based on expert opinion and a literature review. Content validity was performed using three rounds of the Delphi method with experts. Face validity was undertaken by a Persian literature expert and a graphics designer. The questionnaire was distributed among 150 researchers involved in stem cell studies in Royan Institute biology laboratories. We collected 138 completed questionnaires. The mean age of participants was 31.13 ± 5.8 years; most (60.9%) were females. Participants (76.1%) considered the budget to be the most important issue in stem cell research, 79.7% needed financial support from the government, and 77.5% felt that charities could contribute substantially to stem cell research. A total of 90.6% of participants stated that stem cells should lead to commercial usage which could support future researches (86.2%). The aim of stem cell research was stipulated as increasing health status of the society according to 92.8% of the participants. At present, among cell types, importance was attached to cord blood and adult stem cells. Researchers emphasized the importance of mesenchymal stem cells (MSCs) rather than hematopoietic stem cells (HSCs, 57.73%). The prime priorities were given to cancer so that stem cell research could be directed to sphere stem cell research whereas the least preference was given to skin research. Regenerative medicine is considered the future of stem cell research with emphasis on application of these cells, especially in cancer treatment. Copyright© by Royan Institute. All rights reserved.

The Impact of Current and Future Polar Orbiting Satellite Data on Numerical Weather Prediction at NASA/GSFC

NASA Technical Reports Server (NTRS)

Atlas, Robert

2004-01-01

The lack of adequate observational data continues to be recognized as a major factor limiting both atmospheric research and numerical prediction on a variety of temporal and spatial scales. Since the advent of meteorological satellites in the 1960's, a considerable research effort has been directed toward the design of space-borne meteorological sensors, the development of optimal methods for the utilization of these data, (and an assessment of the influence of existing satellite data and the potential influence of future satellite observations on numerical weather prediction. This has included both Observing System Experiments (OSEs) and Observing System Simulation Experiments (OSSEs). OSEs are conducted to evaluate the impact of specific observations or classes of observations on analyses and forecasts. While OSEs are performed with existing data, OSSEs are conducted to evaluate the potential for future observing systems to improve-NWP, as well as to evaluate trade-offs in observing system design, and to develop and test improved methods for data assimilation. At the conference, results from OSEs to evaluate satellite data sets that have recently become available to the global observing system, such as AIRS and Seawinds, and results from OSSEs to determine the potential impact of space-based lidar winds will be presented.

Robots, multi-user virtual environments and healthcare: synergies for future directions.

PubMed

Moon, Ajung; Grajales, Francisco J; Van der Loos, H F Machiel

2011-01-01

The adoption of technology in healthcare over the last twenty years has steadily increased, particularly as it relates to medical robotics and Multi-User Virtual Environments (MUVEs) such as Second Life. Both disciplines have been shown to improve the quality of care and have evolved, for the most part, in isolation from each other. In this paper, we present four synergies between medical robotics and MUVEs that have the potential to decrease resource utilization and improve the quality of healthcare delivery. We conclude with some foreseeable barriers and future research directions for researchers in these fields.

3D Printing: Print the future of ophthalmology.

PubMed

Huang, Wenbin; Zhang, Xiulan

2014-08-26

The three-dimensional (3D) printer is a new technology that creates physical objects from digital files. Recent technological advances in 3D printing have resulted in increased use of this technology in the medical field, where it is beginning to revolutionize medical and surgical possibilities. It is already providing medicine with powerful tools that facilitate education, surgical planning, and organ transplantation research. A good understanding of this technology will be beneficial to ophthalmologists. The potential applications of 3D printing in ophthalmology, both current and future, are explored in this article. Copyright 2014 The Association for Research in Vision and Ophthalmology, Inc.

ROLE OF YOGA IN THE TREATMENT OF NEUROTIC DISORDERS: CURRENT STATUS AND FUTURE DIRECTIONS

PubMed Central

Grover, Poonam; Varma, V.K.; Pershad, D.; Verma, S.K.

1994-01-01

A large number of studies have consistently demonstrated the potential of yoga, not only in the treatment of psychiatric and psychosomatic disorder but also in promoting positive physical and mental health. This paper reviews various studies on the treatment of neurosis with techniques derived from yoga. A few lacunae have been identified and possible directions for future research are outlined. It is hoped that research along these lines will develop a standardized method of yoga therapy which can be utilized and integrated within the existing methods of treatment of neurotic disorders. PMID:21743694

Evidence base and future research directions in the management of low back pain.

PubMed

Abbott, Allan

2016-03-18

Low back pain (LBP) is a prevalent and costly condition. Awareness of valid and reliable patient history taking, physical examination and clinical testing is important for diagnostic accuracy. Stratified care which targets treatment to patient subgroups based on key characteristics is reliant upon accurate diagnostics. Models of stratified care that can potentially improve treatment effects include prognostic risk profiling for persistent LBP, likely response to specific treatment based on clinical prediction models or suspected underlying causal mechanisms. The focus of this editorial is to highlight current research status and future directions for LBP diagnostics and stratified care.

ART/Ada design project, phase 1

NASA Technical Reports Server (NTRS)

1989-01-01

An Ada-Based Expert System Building Tool Design Research Project was conducted. The goal was to investigate various issues in the context of the design of an Ada-based expert system building tool. An attempt was made to achieve a comprehensive understanding of the potential for embedding expert systems in Ada systems for eventual application in future projects. The current status of the project is described by introducing an operational prototype, ART/Ada. How the project was conducted is explained. The performance of the prototype is analyzed and compared with other related works. Future research directions are suggested.

Center for Advanced Computational Technology

NASA Technical Reports Server (NTRS)

Noor, Ahmed K.

2000-01-01

The Center for Advanced Computational Technology (ACT) was established to serve as a focal point for diverse research activities pertaining to application of advanced computational technology to future aerospace systems. These activities include the use of numerical simulations, artificial intelligence methods, multimedia and synthetic environments, and computational intelligence, in the modeling, analysis, sensitivity studies, optimization, design and operation of future aerospace systems. The Center is located at NASA Langley and is an integral part of the School of Engineering and Applied Science of the University of Virginia. The Center has four specific objectives: 1) conduct innovative research on applications of advanced computational technology to aerospace systems; 2) act as pathfinder by demonstrating to the research community what can be done (high-potential, high-risk research); 3) help in identifying future directions of research in support of the aeronautical and space missions of the twenty-first century; and 4) help in the rapid transfer of research results to industry and in broadening awareness among researchers and engineers of the state-of-the-art in applications of advanced computational technology to the analysis, design prototyping and operations of aerospace and other high-performance engineering systems. In addition to research, Center activities include helping in the planning and coordination of the activities of a multi-center team of NASA and JPL researchers who are developing an intelligent synthesis environment for future aerospace systems; organizing workshops and national symposia; as well as writing state-of-the-art monographs and NASA special publications on timely topics.

Enhancing international collaboration among early career researchers.

PubMed

Carroll, Jennifer K; Albada, Akke; Farahani, Mansoureh; Lithner, Maria; Neumann, Melanie; Sandhu, Harbinder; Shepherd, Heather L

2010-09-01

The European Association of Communication in Healthcare (EACH) Early Career Researchers Network (ECRN) aims are to (1) promote international collaboration among young investigators and (2) provide a support network for future innovative communication research projects. In October 2009, Miami, USA at a workshop facilitated by the ECRN at the International Conference on Communication in Healthcare (ICCH) hosted by the American Academy of Communication in Healthcare we explored common facilitators and challenges faced by early career researchers in health communication research. Attendees introduced themselves, their research area(s) of interest, and listed one facilitator and one barrier for their career development. EACH ECRN members then led a discussion of facilitators and challenges encountered in communication research projects and career development. We discussed potential collaboration opportunities, future goals, and activities. Having supportive collegial relationships, institutional support, job security, and funding are critical facilitators for early career investigators. Key challenges include difficulty with time management and prioritizing, limited resources, and contacts. International collaboration among early career researchers is a feasible and effective means to address important challenges, by increasing opportunities for professional support and networking, problem-solving, discussion of data, and ultimately publishing. Future AACH-EACH Early Career Researcher Networks should continue to build collaborations by developing shared research projects, papers, and other scholarly products. Copyright (c) 2010. Published by Elsevier Ireland Ltd.

Enhancing international collaboration among early-career researchers

PubMed Central

Carroll, Jennifer K; Albada, Akke; Farahani, Mansoureh; Lithner, Maria; Neumann, Melanie; Sandhu, Harbinder; Shepherd, Heather L

2010-01-01

Objective The European Association of Communication in Healthcare (EACH) Early Career Researchers Network (ECRN) aims are to (1) promote international collaboration among young investigators and (2) provide a support network for future innovative communication research projects. In October 2009, Miami, USA at a workshop facilitated by the ECRN at the International Conference on Communication in Healthcare (ICCH) hosted by the American Academy of Communication in Healthcare we explored common facilitators and challenges faced by early career researchers in health communication research. Methods Attendees introduced themselves, their research area(s) of interest, and listed one facilitator and one barrier for their career development. EACH ECRN members then led a discussion of facilitators and challenges encountered in communication research projects and career development. We discussed potential collaboration opportunities, future goals, and activities. Results Having supportive collegial relationships, institutional support, job security, and funding are critical facilitators for early career investigators. Key challenges include difficulty with time management and prioritizing, limited resources, and contacts. Conclusion International collaboration among early career researchers is a feasible and effective means to address important challenges, by increasing opportunities for professional support and networking, problem-solving, discussion of data, and ultimately publishing. Practice Implications Future AACH-EACH Early Career Researcher Networks should continue to build collaborations by developing shared research projects, papers, and other scholarly products. PMID:20663630

All over, Red Rover? The Neglect and Potential of Australian Adult Education in the Community

ERIC Educational Resources Information Center

Golding, Barry; Foley, Annette

2011-01-01

Consistent with the "looking back, moving forward" conference theme, in this paper we undertake a critical, research-based appraisal of the current, arguably neglected state of adult education in Australia in 2010, and proceed to paint a picture of how a different and potentially more positive future might be realised. Firstly, we…

A Scholarly Approach to Solving the Feedback Dilemma in Practice

ERIC Educational Resources Information Center

O'Donovan, Berry; Rust, Chris; Price, Margaret

2016-01-01

It is clear from the literature that feedback is potentially the most powerful and potent part of the assessment cycle when it comes to improving further student learning. However, for some time, there has been a growing amount of research evidence that much feedback practice does not fulfil this potential to influence future student learning…

Teaching Arabic with Technology at BYU: Learning from the Past to Bridge to the Future

ERIC Educational Resources Information Center

Bush, Michael D.; Browne, Jeremy M.

2004-01-01

Reporting in 1971 on research related to computer-based methods for teaching the Arabic writing system, Bunderson and Abboud cited the potential that computers have for language learning, a largely unfulfilled potential even in 2004. After a review of the relevant historical background for the justification of computer-aided language learning…

The U. S. DOE Carbon Storage Program: Status and Future Directions

NASA Astrophysics Data System (ADS)

Damiani, D.

2016-12-01

The U.S. Department of Energy (DOE) is taking steps to reduce carbon dioxide (CO2) emissions through clean energy innovation, including carbon capture and storage (CCS) research. The Office of Fossil Energy Carbon Storage Program is focused on ensuring the safe and permanent storage and/or utilization of CO2 captured from stationary sources. The Program is developing and advancing geologic storage technologies both onshore and offshore that will significantly improve the effectiveness of CCS, reduce the cost of implementation, and be ready for widespread commercial deployment in the 2025-2035 timeframe. The technology development and field testing conducted through this Program will be used to benefit the existing and future fleet of fossil fuel power generating and industrial facilities by creating tools to increase our understanding of geologic reservoirs appropriate for CO2 storage and the behavior of CO2 in the subsurface. The Program is evaluating the potential for storage in depleted oil and gas reservoirs, saline formations, unmineable coal, organic-rich shale formations, and basalt formations. Since 1997, DOE's Carbon Storage Program has significantly advanced the CCS knowledge base through a diverse portfolio of applied research projects. The Core Storage R&D research component focuses on analytic studies, laboratory, and pilot- scale research to develop technologies that can improve wellbore integrity, increase reservoir storage efficiency, improve management of reservoir pressure, ensure storage permanence, quantitatively assess risks, and identify and mitigate potential release of CO2 in all types of storage formations. The Storage Field Management component focuses on scale-up of CCS and involves field validation of technology options, including large-volume injection field projects at pre-commercial scale to confirm system performance and economics. Future research involves commercial-scale characterization for regionally significant storage locations capable of storing from 50 to 100 million metric tons of CO2 in a saline formation. These projects will lay the foundation for fully integrated carbon capture and storage demonstrations of future first of a kind (FOAK) coal power projects. Future research will also bring added focus on offshore CCS.

Future research needs associated with the assessment of potential human health risks from exposure to toxic ambient air pollutants.

PubMed Central

Möller, L; Schuetzle, D; Autrup, H

1994-01-01

This paper presents key conclusions and future research needs from a Workshop on the Risk Assessment of Urban Air, Emissions, Exposure, Risk Identification, and Quantification, which was held in Stockholm during June 1992 by 41 participants from 13 countries. Research is recommended in the areas of identification and quantification of toxics in source emissions and ambient air, atmospheric transport and chemistry, exposure level assessment, the development of improved in vitro bioassays, biomarker development, the development of more accurate epidemiological methodologies, and risk quantification techniques. Studies are described that will be necessary to assess and reduce the level of uncertainties associated with each step of the risk assessment process. International collaborative research efforts between industry and government organizations are recommended as the most effective way to carry out this research. PMID:7529703

A synergistic glance at the prospects of distributed propulsion technology and the electric aircraft concept for future unmanned air vehicles and commercial/military aviation

NASA Astrophysics Data System (ADS)

Gohardani, Amir S.

2013-02-01

Distributed propulsion is one of the revolutionary candidates for future aircraft propulsion. In this journal article, the potential role of distributed propulsion technology in future aviation is investigated. Following a historical journey that revisits distributed propulsion technology in unmanned air vehicles and military aircraft, features of this specific technology are highlighted in synergy with an electric aircraft concept and a first-of-a-kind comparison to commercial aircraft employing distributed propulsion arrangements. In light of propulsion-airframe integration and complementary technologies such as boundary layer ingestion, thrust vectoring and circulation control, transpired opportunities and challenges are addressed in addition to a number of identified research directions proposed for future aircraft. The motivation behind enhanced means of communication between engineers, researchers and scientists has stimulated a novel proposed definition for the distributed propulsion technology in aviation and is presented herein.

Forgiveness and Consideration of Future Consequences in Aggressive Driving

PubMed Central

Moore, Michael; Dahlen, Eric R.

2008-01-01

Most research on aggressive driving has focused on identifying aspects of driver personality which will exacerbate it (e.g., sensation seeking, impulsiveness, driving anger, etc.). The present study was designed to examine two theoretically relevant but previously unexplored personality factors predicted to reduce the risk of aggressive driving: trait forgiveness and consideration of future consequences. The utility of these variables in predicting aggressive driving and driving anger expression was evaluated among 316 college student volunteers. Hierarchical multiple regressions permitted an analysis of the incremental validity of these constructs beyond respondent gender, age, miles driven per week, and driving anger. Both forgiveness and consideration of future consequences contributed to the prediction of aggressive driving and driving anger expression, independent of driving anger. Research on aggressive driving may be enhanced by greater attention to adaptive, potentially risk-reducing traits. Moreover, forgiveness and consideration of future consequences may have implications for accident prevention. PMID:18760093

Hydrogen Fuel Cells | Transportation Research | NREL

Science.gov Websites

Leading Role Hydrogen, a flexible, clean energy-carrying intermediate, has the potential to be a " webinar focused on the role that hydrogen at grid scale could play in our nation's energy future

Recommender systems

NASA Astrophysics Data System (ADS)

Lü, Linyuan; Medo, Matúš; Yeung, Chi Ho; Zhang, Yi-Cheng; Zhang, Zi-Ke; Zhou, Tao

2012-10-01

The ongoing rapid expansion of the Internet greatly increases the necessity of effective recommender systems for filtering the abundant information. Extensive research for recommender systems is conducted by a broad range of communities including social and computer scientists, physicists, and interdisciplinary researchers. Despite substantial theoretical and practical achievements, unification and comparison of different approaches are lacking, which impedes further advances. In this article, we review recent developments in recommender systems and discuss the major challenges. We compare and evaluate available algorithms and examine their roles in the future developments. In addition to algorithms, physical aspects are described to illustrate macroscopic behavior of recommender systems. Potential impacts and future directions are discussed. We emphasize that recommendation has great scientific depth and combines diverse research fields which makes it interesting for physicists as well as interdisciplinary researchers.

NASA advanced space photovoltaic technology-status, potential and future mission applications

NASA Technical Reports Server (NTRS)

Flood, Dennis J.; Piszczor, Michael, Jr.; Stella, Paul M.; Bennett, Gary L.

1989-01-01

The NASA program in space photovoltaic research and development encompasses a wide range of emerging options for future space power systems, and includes both cell and array technology development. The long range goals are to develop technology capable of achieving 300 W/kg for planar arrays, and 300 W/sq m for concentrator arrays. InP and GaAs planar and concentrator cell technologies are under investigation for their potential high efficiency and good radiation resistance. The Advanced Photovoltaic Solar Array (APSA) program is a near term effort aimed at demonstrating 130 W/kg beginning of life specific power using thin (62 micrometer) silicon cells. It is intended to be technology transparent to future high efficiency cells and provides the baseline for development of the 300 W/kg array.

Assessing consumer responses to potential reduced-exposure tobacco products: a review of tobacco industry and independent research methods.

PubMed

Rees, Vaughan W; Kreslake, Jennifer M; Cummings, K Michael; O'Connor, Richard J; Hatsukami, Dorothy K; Parascandola, Mark; Shields, Peter G; Connolly, Gregory N

2009-12-01

Internal tobacco industry documents and the mainstream literature are reviewed to identify methods and measures for evaluating tobacco consumer response. The review aims to outline areas in which established methods exist, identify gaps in current methods for assessing consumer response, and consider how these methods might be applied to evaluate potentially reduced exposure tobacco products and new products. Internal industry research reviewed included published articles, manuscript drafts, presentations, protocols, and instruments relating to consumer response measures were identified and analyzed. Peer-reviewed research was identified using PubMed and Scopus. Industry research on consumer response focuses on product development and marketing. To develop and refine new products, the tobacco industry has developed notable strategies for assessing consumers' sensory and subjective responses to product design characteristics. Independent research is often conducted to gauge the likelihood of future product adoption by measuring consumers' risk perceptions, responses to product, and product acceptability. A model that conceptualizes consumer response as comprising the separate, but interacting, domains of product perceptions and response to product is outlined. Industry and independent research supports the dual domain model and provides a wide range of methods for assessment of the construct components of consumer response. Further research is needed to validate consumer response constructs, determine the relationship between consumer response and tobacco user behavior, and improve reliability of consumer response measures. Scientifically rigorous consumer response assessment methods will provide a needed empirical basis for future regulation of potentially reduced-exposure tobacco products and new products, to counteract tobacco industry influence on consumers, and enhance the public health.

Analysis of DoD Travel Management: An Application of Learning Curve Theory.

DTIC Science & Technology

1982-09-01

tI AFIT Control Number LSSR 72-82 AFIT RESEARCH ASSESSMENT The purpose of this questionnaire is to determine the potential for current and future...by the equivalent value that your agency received by virtue of AFIT performing the research . Can you estimate what this research would have cost if it...In-house). 4. Often it is not possible to attach equivalent dollar values to research , although the results of the research may, in fact, be

Research on the International Space Station: Understanding Future Potential from Current Accomplishments

NASA Technical Reports Server (NTRS)

Robinson, Julie A.

2007-01-01

In November 2007, the International Space Station (ISS) will have supported seven years of continuous presence in space, with 15 Expeditions completed. These years have been characterized by the numerous technical challenges of assembly as well as operational and logistical challenges related to the availability of transportation by the Space Shuttle. During this period, an active set of early research objectives have also been accomplished alongside the assembly. This paper will review the research accomplishments on ISS to date, with the objective of drawing insights on the potential of future research following completion of ISS assembly. By the end of Expedition 15, an expected 121 U.S.-managed investigations will have been conducted on ISS, with 91 of these completed. Many of these investigations include multiple scientific objectives, with an estimated total of 334 scientists served. Through February 2007, 101 scientific publications have been identified. Another 184 investigations have been sponsored by ISS international partners, which independently track their scientists served and results publication. Through this survey of U.S. research completed on ISS, three different themes will be addressed: (1) How have constraints on transportation of mass to orbit affected the types of research successfully completed on the ISS to date? What lessons can be learned for increasing the success of ISS as a research platform during the period following the retirement of the Space Shuttle? (2) How have constraints on crew time for research during assembly and the active participation of crewmembers as scientists affected the types of research successfully completed on the ISS to date? What lessons can be learned for optimizing research return following the increase in capacity from 3 to 6 crewmembers (planned for 2009)? What lessons can be learned for optimizing research return after assembly is complete? (3) What do early research results indicate about the various scientific disciplines represented in investigations on ISS? Are there lessons specific to human research, technology development, life sciences, and physical sciences that can be used to increase future research accomplishments? Research has been conducted and completed on ISS under a set of challenging constraints during the past 7 years. The history of research accomplished on ISS during this time serves as an indicator of the value and potential of ISS when full utilization begins. By learning from our early experience in completing research on ISS, NASA and our partners can be positioned to optimize research returns as a full crew complement comes onboard, assembly is completed, and research begins in full.

New directions in e-learning research in health professions education: Report of two symposia.

PubMed

Triola, Marc M; Huwendiek, Sören; Levinson, Anthony J; Cook, David A

2012-01-01

The use of Computer Assisted Instruction (CAI) is rising across health professions education. Research to date is of limited use in guiding the implementation and selection of CAI innovations. In the context of two symposia, systemic reviews were discussed that evaluate literature in Internet-based learning, Virtual Patients, and animations. Each session included a debate with the goal of reaching consensus on best current practices and future research. Thematic analysis of the discussions was performed to arrange the questions by theme, eliminate redundancy, and craft them into a cohesive narrative. The question analysis revealed that there are clear advantages to the use of CAI, and that established educational theories should certainly inform the future development and selection of CAI tools. Schools adopting CAI need to carefully consider the benefits, cost, available resources, and capacity for teachers and learners to accept change in their practice of education. Potential areas for future research should focus on the effectiveness of CAI instructional features, integration of e-learning into existing curricula and with other modalities like simulation, and the use of CAI in assessment of higher-level outcomes. There are numerous opportunities for future research and it will be important to achieve consensus on important themes.

Dielectrophoresis for Biomedical Sciences Applications: A Review

PubMed Central

Abd Rahman, Nurhaslina; Ibrahim, Fatimah; Yafouz, Bashar

2017-01-01

Dielectrophoresis (DEP) is a label-free, accurate, fast, low-cost diagnostic technique that uses the principles of polarization and the motion of bioparticles in applied electric fields. This technique has been proven to be beneficial in various fields, including environmental research, polymer research, biosensors, microfluidics, medicine and diagnostics. Biomedical science research is one of the major research areas that could potentially benefit from DEP technology for diverse applications. Nevertheless, many medical science research investigations have yet to benefit from the possibilities offered by DEP. This paper critically reviews the fundamentals, recent progress, current challenges, future directions and potential applications of research investigations in the medical sciences utilizing DEP technique. This review will also act as a guide and reference for medical researchers and scientists to explore and utilize the DEP technique in their research fields. PMID:28245552

Helicopter technology benefits and needs. Volume 1: Summary

NASA Technical Reports Server (NTRS)

Zuk, J.; Adams, R. J.

1980-01-01

Present public service helicopter benefits and the potential benefits of an advanced public service rotorcraft (200 knots to 300 knots) are summarized. Past and future public service growth is quantified and assessed and needs, problem areas, and desired vehicle characteristics are defined. Research and technology recommendations are formulated and the costs and benefits of research options are assessed.

SEURAT: Safety Evaluation Ultimately Replacing Animal Testing – Recommendations for future research in the field of predictive toxicology

EPA Science Inventory

The development of non-animal methodology to evaluate the potential for a chemical to cause systemic toxicity is one of the grand challenges of modern science. The European research programme SEURAT is active in this field and will conclude its first phase, SEURAT-1, in December ...

Games and Simulations in Online Learning: Research and Development Frameworks

ERIC Educational Resources Information Center

Gibson, David; Aldrich, Clark; Prensky, Marc

2007-01-01

Games and Simulations in Online Learning: Research and Development Frameworks examines the potential of games and simulations in online learning, and how the future could look as developers learn to use the emerging capabilities of the Semantic Web. It presents a general understanding of how the Semantic Web will impact education and how games and…

Modeling the yield potential of dryland canola under current and future climates in California

NASA Astrophysics Data System (ADS)

George, N.; Kaffka, S.; Beeck, C.; Bucaram, S.; Zhang, J.

2012-12-01

Models predict that the climate of California will become hotter, drier and more variable under future climate change scenarios. This will lead to both increased irrigation demand and reduced irrigation water availability. In addition, it is predicted that most common Californian crops will suffer a concomitant decline in productivity. To remain productive and economically viable, future agricultural systems will need to have greater water use efficiency, tolerance of high temperatures, and tolerance of more erratic temperature and rainfall patterns. Canola (Brassica napus) is the third most important oilseed globally, supporting large and well-established agricultural industries in Canada, Europe and Australia. It is an agronomically useful and economically valuable crop, with multiple end markets, that can be grown in California as a dryland winter rotation with little to no irrigation demand. This gives canola great potential as a new crop for Californian farmers both now and as the climate changes. Given practical and financial limitations it is not always possible to immediately or widely evaluate a crop in a new region. Crop production models are therefore valuable tools for assessing the potential of new crops, better targeting further field research, and refining research questions. APSIM is a modular modeling framework developed by the Agricultural Production Systems Research Unit in Australia, it combines biophysical and management modules to simulate cropping systems. This study was undertaken to examine the yield potential of Australian canola varieties having different water requirements and maturity classes in California using APSIM. The objective of the work was to identify the agricultural regions of California most ideally suited to the production of Australian cultivars of canola and to simulate the production of canola in these regions to estimate yield-potential. This will establish whether the introduction and in-field evaluation of better-adapted canola varieties can be justified, and the potential value of a California canola industry both now and in the future. Winter annual crops like canola use rainfall in a Mediterranean climate like California more efficiently than spring or summer crops. Our results suggest that under current production costs and seed prices, dry farmed canola will have good potential in certain areas of the California. Canola yields decline with annual winter precipitation, however economically viable yields are still achieved at relatively precipitation levels (200 mm). Results from simulation, combined with related economic modeling (reported elsewhere) suggest that canola will be viable in a variety of production systems in the northern Sacramento Valley and some coastal locations, even under drier future climate scenarios. The in-field evaluation of Australian canola varieties should contribute to maintain or improving resource use efficiency and farm profitability.

2015 SHC BOSC Poster on the EPA/NIMHD Centers of ...

EPA Pesticide Factsheets

EPA supports research that will help in the understanding and prevention of health disparities from environmental conditions and pollution. Racial/ethnic and economic disparities cause many health problems and are very costly to our society. EPA seeks to ensure that no community bears a disproportionate burden, especially those which are susceptible, vulnerable, or socioeconomically disadvantaged. The 2015 SHC BOSC Poster on the EPA/NIMHD Centers of Excellence on Environmental Health Disparities Research provides a summary of the EPA/NIMHD joint Centers. It discusses the purpose and utility of the research, its connection to the SHC portfolio, research highlights, as well as potential application and translation of the results. The poster also includes a list of intended users for the research, potential lessons learned, and provides a snapshot of future health disparities research.

If We Don’t, Who Will? The Employment of the United States Army to Combat Potential Pandemic Outbreaks in West Africa

DTIC Science & Technology

2015-06-12

27 viii Threats to Validity and Biases ...draw conclusions and make recommendations for future research. Threats to Validity and Biases There are a several issues that pose a threat to...validity and bias to the research. Threats to validity affect the accuracy of the research and soundness of the conclusion. Threats to external validity

Lab to Farm: Applying Research on Plant Genetics and Genomics to Crop Improvement

PubMed Central

Ronald, Pamela C.

2014-01-01

Over the last 300 years, plant science research has provided important knowledge and technologies for advancing the sustainability of agriculture. In this Essay, I describe how basic research advances have been translated into crop improvement, explore some lessons learned, and discuss the potential for current and future contribution of plant genetic improvement technologies to continue to enhance food security and agricultural sustainability. PMID:24915201

Research and Development for Technology Evolution Potential Forecasting System

NASA Astrophysics Data System (ADS)

Gao, Changqing; Cao, Shukun; Wang, Yuzeng; Ai, Changsheng; Ze, Xiangbo

Technology forecasting is a powerful weapon for many enterprises to gain an animate future. Evolutionary potential radar plot is a necessary step of some valuable methods to help the technology managers with right technical strategy. A software system for Technology Evolution Potential Forecasting (TEPF) with automatic radar plot drawing is introduced in this paper. The framework of the system and the date structure describing the concrete evolution pattern are illustrated in details. And the algorithm for radar plot drawing is researched. It is proved that the TEPF system is an effective tool during the technology strategy analyzing process with a referenced case study.

Environmental determinants of polycystic ovary syndrome.

PubMed

Merkin, Sharon Stein; Phy, Jennifer L; Sites, Cynthia K; Yang, Dongzi

2016-07-01

In this review, we summarize existing research on a variety of environmental factors potentially involved in the etiology, prevalence, and modulation of polycystic ovary syndrome (PCOS), and we suggest avenues for future research. The main environmental factors we consider include environmental toxins, diet and nutrition, socioeconomic status, and geography. There is some evidence that environmental toxins play a role in disrupting reproductive health, but there is limited research as to how these toxins may affect the development of PCOS. Although research has also shown that PCOS symptoms are reduced with certain dietary supplements and with weight loss among obese women, additional research is needed to compare various approaches to weight loss, as well as nutritional factors that may play a role in preventing or mitigating the development of PCOS. Limited studies indicate some association of low socioeconomic status with certain PCOS phenotypes, and future research should consider socioeconomic conditions during childhood or adolescence that may be more relevant to the developmental onset of PCOS. Finally, the limited scope of comparable international studies on PCOS needs to be addressed, because global patterns of PCOS are potentially valuable indicators of cultural, environmental, and genetic factors that may contribute to excess risk in certain regions of the world. Copyright © 2016 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.

Higher Education into the 1990s: New Dimensions. To Commemorate the Jubilee of the Society for Research into Higher Education, 1964-1989.

ERIC Educational Resources Information Center

Ball, Christopher, Ed.; Eggins, Heather, Ed.

This collection of essays aims to contribute to the understanding of the present predicament and future potential of higher education in the United Kingdom. It considers the new dimensions being introduced into higher education which are likely to have marked effects in the 1990s. It explores the tensions between the past and future, tradition and…

Intrauterine devices: learning from the past and looking to the future.

PubMed

Petta, C A; McPheeters, M; Chi, I C

1996-04-01

This paper reviews the historical development of the IUD, describing the challenges and successes, and attempts to offer a balanced perspective for family planning service workers today. Modern IUDs are an important component of family planning services and an excellent contraceptive choice for properly screened women, providing contraception that is safe, effective, long lasting and cost effective. Potential research strategies for the future are also discussed.

What Future for Technical & Vocational Education & Training? Selected papers presented at the International Conference of the National Centre for Vocational Education Research (Melbourne, Victoria, Australia, December 14-18, 1992).

ERIC Educational Resources Information Center

Hall, William C., Ed.

This collection of articles of international appeal on the future of vocational and technical education and training begins with an introduction by William Hall and includes the following papers: "New Vocationalism in the United States: Potential Problems and Outlook" (Benson); "Learning within a Work Context: Training Concepts,…

Aircraft Research and Technology for Future Fuels

NASA Technical Reports Server (NTRS)

1980-01-01

The potential characteristics of future aviation turbine fuels and the property effects of these fuels on propulsion system components are examined. The topics that are discussed include jet fuel supply and demand trends, the effects of refining variables on fuel properties, shekle oil processing, the characteristics of broadened property fuels, the effects of fuel property variations on combustor and fuel system performance, and combuster and fuel system technology for broadened property fuels.

High Performance Computing and Enabling Technologies for Nano and Bio Systems and Interfaces

DTIC Science & Technology

2014-12-12

data analysis of protein – aptamer interaction systems were developed. All research investigations contributed to the research education , and training...achieved a 3.5 GPA to 4.0 (4.0 max scale): Number of graduating undergraduates funded by a DoD funded Center of Excellence grant for Education , Research...Research, education and training of future US work force in such nano- bio systems have significant potential for advancement in medical and health

Evaluating the Potential of NASA's Earth Science Research Results for Improving Future Operational Systems

NASA Astrophysics Data System (ADS)

Frederick, M. E.; Cox, E. L.; Friedl, L. A.

2006-12-01

NASA's Earth Science Theme is charged with implementing NASA Strategic Goal 3A to "study Earth from space to advance scientific understanding and meet societal needs." In the course of meeting this objective, NASA produces research results, such as scientific observatories, research models, advanced sensor and space system technology, data active archives and interoperability technology, high performance computing systems, and knowledge products. These research results have the potential to serve society beyond their intended purpose of answering pressing Earth system science questions. NASA's Applied Sciences Program systematically evaluates the potential of the portfolio of research results to serve society by conducting projects in partnership with regional/national scale operational partners with the statutory responsibility to inform decision makers. These projects address NASA's National Applications and the societal benefit areas under the IEOS and GEOSS. Prototyping methods are used in two ways in NASA's Applied Sciences Program. The first is part of the National Applications program element, referred to as Integrated Systems Solutions (ISS) projects. The approach for these projects is to use high fidelity prototypes to benchmark the assimilation of NASA research results into our partners' decision support systems. The outcome from ISS projects is a prototype system that has been rigorously tested with the partner to understand the scientific uncertainty and improved value of their modified system. In many cases, these completed prototypes are adopted or adapted for use by the operational partners. The second falls under the Crosscutting Solutions program element, referred to as Rapid Prototyping (RP) experiments. The approach for RP experiments is to use low fidelity prototypes that are low cost and quickly produced to evaluate the potential of the breadth of NASA research results to serve society. The outcome from the set of RP experiments is an evaluation of many and varied NASA research results for their potential to be candidates for further development as an ISS project. The intention is to seed the community with many creative ideas for projects that use "un-applied" NASA research results to serve society, such as simulations of future missions.

Why are dreams interesting for philosophers? The example of minimal phenomenal selfhood, plus an agenda for future research1

PubMed Central

Metzinger, Thomas

2013-01-01

This metatheoretical paper develops a list of new research targets by exploring particularly promising interdisciplinary contact points between empirical dream research and philosophy of mind. The central example is the MPS-problem. It is constituted by the epistemic goal of conceptually isolating and empirically grounding the phenomenal property of “minimal phenomenal selfhood,” which refers to the simplest form of self-consciousness. In order to precisely describe MPS, one must focus on those conditions that are not only causally enabling, but strictly necessary to bring it into existence. This contribution argues that research on bodiless dreams, asomatic out-of-body experiences, and full-body illusions has the potential to make decisive future contributions. Further items on the proposed list of novel research targets include differentiating the concept of a “first-person perspective” on the subcognitive level; investigating relevant phenomenological and neurofunctional commonalities between mind-wandering and dreaming; comparing the functional depth of embodiment across dream and wake states; and demonstrating that the conceptual consequences of cognitive corruption and systematic rationality deficits in the dream state are much more serious for philosophical epistemology (and, perhaps, the methodology of dream research itself) than commonly assumed. The paper closes by specifying a list of potentially innovative research goals that could serve to establish a stronger connection between dream research and philosophy of mind. PMID:24198793

Why are dreams interesting for philosophers? The example of minimal phenomenal selfhood, plus an agenda for future research.

PubMed

Metzinger, Thomas

2013-01-01

This metatheoretical paper develops a list of new research targets by exploring particularly promising interdisciplinary contact points between empirical dream research and philosophy of mind. The central example is the MPS-problem. It is constituted by the epistemic goal of conceptually isolating and empirically grounding the phenomenal property of "minimal phenomenal selfhood," which refers to the simplest form of self-consciousness. In order to precisely describe MPS, one must focus on those conditions that are not only causally enabling, but strictly necessary to bring it into existence. This contribution argues that research on bodiless dreams, asomatic out-of-body experiences, and full-body illusions has the potential to make decisive future contributions. Further items on the proposed list of novel research targets include differentiating the concept of a "first-person perspective" on the subcognitive level; investigating relevant phenomenological and neurofunctional commonalities between mind-wandering and dreaming; comparing the functional depth of embodiment across dream and wake states; and demonstrating that the conceptual consequences of cognitive corruption and systematic rationality deficits in the dream state are much more serious for philosophical epistemology (and, perhaps, the methodology of dream research itself) than commonly assumed. The paper closes by specifying a list of potentially innovative research goals that could serve to establish a stronger connection between dream research and philosophy of mind.

Institutionalization of evidence-informed practices in healthcare settings

PubMed Central

2012-01-01

Background The effective and timely integration of the best available research evidence into healthcare practice has considerable potential to improve the quality of provided care. Knowledge translation (KT) approaches aim to develop, implement, and evaluate strategies to address the research-practice gap. However, most KT research has been directed toward implementation strategies that apply cognitive, behavioral, and, to a lesser extent, organizational theories. In this paper, we discuss the potential of institutional theory to inform KT-related research. Discussion Despite significant research, there is still much to learn about how to achieve KT within healthcare systems and practices. Institutional theory, focusing on the processes by which new ideas and concepts become accepted within their institutional environments, holds promise for advancing KT efforts and research. To propose new directions for future KT research, we present some of the main concepts of institutional theory and discuss their application to KT research by outlining how institutionalization of new practices can lead to their ongoing use in organizations. In addition, we discuss the circumstances under which institutionalized practices dissipate and give way to new insights and ideas that can lead to new, more effective practices. Summary KT research informed by institutional theory can provide important insights into how knowledge becomes implemented, routinized, and accepted as institutionalized practices. Future KT research should employ both quantitative and qualitative research designs to examine the specifics of sustainability, institutionalization, and deinstitutionalization of practices to enhance our understanding of these complex constructs. PMID:23171660

Institutionalization of evidence-informed practices in healthcare settings.

PubMed

Novotná, Gabriela; Dobbins, Maureen; Henderson, Joanna

2012-11-21

The effective and timely integration of the best available research evidence into healthcare practice has considerable potential to improve the quality of provided care. Knowledge translation (KT) approaches aim to develop, implement, and evaluate strategies to address the research-practice gap. However, most KT research has been directed toward implementation strategies that apply cognitive, behavioral, and, to a lesser extent, organizational theories. In this paper, we discuss the potential of institutional theory to inform KT-related research. Despite significant research, there is still much to learn about how to achieve KT within healthcare systems and practices. Institutional theory, focusing on the processes by which new ideas and concepts become accepted within their institutional environments, holds promise for advancing KT efforts and research. To propose new directions for future KT research, we present some of the main concepts of institutional theory and discuss their application to KT research by outlining how institutionalization of new practices can lead to their ongoing use in organizations. In addition, we discuss the circumstances under which institutionalized practices dissipate and give way to new insights and ideas that can lead to new, more effective practices. KT research informed by institutional theory can provide important insights into how knowledge becomes implemented, routinized, and accepted as institutionalized practices. Future KT research should employ both quantitative and qualitative research designs to examine the specifics of sustainability, institutionalization, and deinstitutionalization of practices to enhance our understanding of these complex constructs.

Unconventional fossil-based fuels : economic and environmental trade-offs

DOT National Transportation Integrated Search

2008-01-01

Both high import payments for petroleum motor fuels and concerns regarding emissions of carbon dioxide (CO2) are motivating interest in possible fuel substitutes. In this report, RAND researchers assess the potential future production levels, product...

Chicoric acid: chemistry, distribution, and production

NASA Astrophysics Data System (ADS)

Lee, Jungmin; Scagel, Carolyn

2013-12-01

Though chicoric acid was first identified in 1958, it was largely ignored until recent popular media coverage cited potential health beneficial properties from consuming food and dietary supplements containing this compound. To date, plants from at least 63 genera and species have been found to contain chicoric acid, and while the compound is used as a processing quality indicator, it may also have useful health benefits. This review of chicoric acid summarizes research findings and highlights gaps in research knowledge for investigators, industry stakeholders, and consumers alike. Additionally, chicoric acid identification and quantification methods, biosynthesis, processing improvements to increase chicoric acid retention, and potential areas for future research are discussed.

Chicoric acid: chemistry, distribution, and production.

PubMed

Lee, Jungmin; Scagel, Carolyn F

2013-01-01

Though chicoric acid was first identified in 1958, it was largely ignored until recent popular media coverage cited potential health beneficial properties from consuming food and dietary supplements containing this compound. To date, plants from at least 63 genera and species have been found to contain chicoric acid, and while the compound is used as a processing quality indicator, it may also have useful health benefits. This review of chicoric acid summarizes research findings and highlights gaps in research knowledge for investigators, industry stakeholders, and consumers alike. Additionally, chicoric acid identification, and quantification methods, biosynthesis, processing improvements to increase chicoric acid retention, and potential areas for future research are discussed.

Chicoric acid: chemistry, distribution, and production

PubMed Central

Lee, Jungmin; Scagel, Carolyn F.

2013-01-01

Though chicoric acid was first identified in 1958, it was largely ignored until recent popular media coverage cited potential health beneficial properties from consuming food and dietary supplements containing this compound. To date, plants from at least 63 genera and species have been found to contain chicoric acid, and while the compound is used as a processing quality indicator, it may also have useful health benefits. This review of chicoric acid summarizes research findings and highlights gaps in research knowledge for investigators, industry stakeholders, and consumers alike. Additionally, chicoric acid identification, and quantification methods, biosynthesis, processing improvements to increase chicoric acid retention, and potential areas for future research are discussed. PMID:24790967

Using Community-Based Participatory Research and Human-Centered Design to Address Violence-Related Health Disparities Among Latino/a Youth.

PubMed

Kia-Keating, Maryam; Santacrose, Diana E; Liu, Sabrina R; Adams, Jessica

High rates of exposure to violence and other adversities among Latino/a youth contribute to health disparities. The current article addresses the ways in which community-based participatory research (CBPR) and human-centered design (HCD) can help engage communities in dialogue and action. We present a project exemplifying how community forums, with researchers, practitioners, and key stakeholders, including youths and parents, integrated HCD strategies with a CBPR approach. Given the potential for power inequities among these groups, CBPR + HCD acted as a catalyst for reciprocal dialogue and generated potential opportunity areas for health promotion and change. Future directions are described.

Cluster Analysis in Nursing Research: An Introduction, Historical Perspective, and Future Directions.

PubMed

Dunn, Heather; Quinn, Laurie; Corbridge, Susan J; Eldeirawi, Kamal; Kapella, Mary; Collins, Eileen G

2017-05-01

The use of cluster analysis in the nursing literature is limited to the creation of classifications of homogeneous groups and the discovery of new relationships. As such, it is important to provide clarity regarding its use and potential. The purpose of this article is to provide an introduction to distance-based, partitioning-based, and model-based cluster analysis methods commonly utilized in the nursing literature, provide a brief historical overview on the use of cluster analysis in nursing literature, and provide suggestions for future research. An electronic search included three bibliographic databases, PubMed, CINAHL and Web of Science. Key terms were cluster analysis and nursing. The use of cluster analysis in the nursing literature is increasing and expanding. The increased use of cluster analysis in the nursing literature is positioning this statistical method to result in insights that have the potential to change clinical practice.

Conducting Polymers and Their Applications in Diabetes Management.

PubMed

Zhao, Yu; Cao, Luyao; Li, Lanlan; Cheng, Wen; Xu, Liangliang; Ping, Xinyu; Pan, Lijia; Shi, Yi

2016-10-26

Advances in conducting polymers (CPs) have promoted the development of diabetic monitoring and treatment, which is of great significance in human healthcare and modern medicine. CPs are special polymers with physical and electrochemical features resembling metals, inorganic semiconductors and non-conducting polymers. To improve and extend their properties, the fabrication of CPs and CP composites has attracted intensive attention in recent decades. Some CPs are biocompatible and suitable for biomedical use. Thus, the intriguing properties of CPs make wearable, noninvasive, continuous diabetes managing devices and other potential applications in diabetes possible in the near future. To highlight the recent advances of CPs and their derived materials (especially in conducting polymer hydrogels), here we discuss their fabrication and characterization, review the current state-of-the-art research in diabetes management based on these materials and describe current challenges as well as future potential research directions.

Messages from the Malaysian Diabetes Registries on Diabetes Care in Malaysian public healthcare facilities.

PubMed

Chew, Boon-How; Lee, Ping-Yein; Cheong, Ai-Theng; Ismail, Mastura; Shariff-Ghazali, Sazlina; Goh, Pik-Pin

2016-10-01

A persistent and increasing prevalence of diagnosed and undiagnosed diabetes mellitus has recently been reported in the National Health and Morbidity Survey 2015. This commentary recapitulates the relevant and valuable lessons in the Malaysian national diabetes registries to inform the healthcare stakeholders and policy makers on potential areas of clinical practice improvement and future researches. Under performance of the process measures and sub-optimal control of HbA1c, blood pressure and lipids profile were prevalent (<40% achieved treatment targets). Although these had improved slightly from 2009 to 2012, diabetes co-morbidities (hypertension and dyslipidaemia) and complications had also increased. Prevalence of insulin use had doubled, and lipid lowering agent use had increased about 50% in 2012 compared to 2009. We identified six clinical areas for urgent attention and improvement, and three potential areas for future research. Copyright © 2016 Primary Care Diabetes Europe. Published by Elsevier Ltd. All rights reserved.

Conducting Polymers and Their Applications in Diabetes Management

PubMed Central

Zhao, Yu; Cao, Luyao; Li, Lanlan; Cheng, Wen; Xu, Liangliang; Ping, Xinyu; Pan, Lijia; Shi, Yi

2016-01-01

Advances in conducting polymers (CPs) have promoted the development of diabetic monitoring and treatment, which is of great significance in human healthcare and modern medicine. CPs are special polymers with physical and electrochemical features resembling metals, inorganic semiconductors and non-conducting polymers. To improve and extend their properties, the fabrication of CPs and CP composites has attracted intensive attention in recent decades. Some CPs are biocompatible and suitable for biomedical use. Thus, the intriguing properties of CPs make wearable, noninvasive, continuous diabetes managing devices and other potential applications in diabetes possible in the near future. To highlight the recent advances of CPs and their derived materials (especially in conducting polymer hydrogels), here we discuss their fabrication and characterization, review the current state-of-the-art research in diabetes management based on these materials and describe current challenges as well as future potential research directions. PMID:27792179

Melatonin and mitochondrial function during ischemia/reperfusion injury.

PubMed

Ma, Zhiqiang; Xin, Zhenlong; Di, Wencheng; Yan, Xiaolong; Li, Xiaofei; Reiter, Russel J; Yang, Yang

2017-11-01

Ischemia/reperfusion (IR) injury occurs in many organs and tissues, and contributes to morbidity and mortality worldwide. Melatonin, an endogenously produced indolamine, provides a strong defense against IR injury. Mitochondrion, an organelle for ATP production and a decider for cell fate, has been validated to be a crucial target for melatonin to exert its protection against IR injury. In this review, we first clarify the mechanisms underlying mitochondrial dysfunction during IR and melatonin's protection of mitochondria under this condition. Thereafter, special focus is placed on the protective actions of melatonin against IR injury in brain, heart, liver, and others. Finally, we explore several potential future directions of research in this area. Collectively, the information compiled here will serve as a comprehensive reference for the actions of melatonin in IR injury identified to date and will hopefully aid in the design of future research and increase the potential of melatonin as a therapeutic agent.

Rationale for Using Social Media to Collect Patient-Reported Outcomes in Patients with Celiac Disease.

PubMed

Park, Kt; Harris, Merissa; Khavari, Nasim; Khosla, Chaitan

2014-02-01

Patients with celiac disease (CD) are increasingly interconnected through social media, exchanging patient experiences and health-tracking information between individuals through various web-based platforms. Social media represents potentially unique communication interface between gastroenterologists and active social media users - especially young adults and adolescents with celiac disease-regarding adherence to the strict gluten-free diet, gastrointestinal symptoms, and meaningful discussion about disease management. Yet, various social media platforms may be underutilized for research purposes to collect patient-reported outcomes data. In this commentary, we summarize the scientific rationale and potential for future growth of social media in patient-reported outcomes research, focusing on college freshmen with celiac disease as a case study and provide overview of the methodological approach. Finally, we discuss how social media may impact patient care in the future through increasing mobile technology use.

Will our children be healthy adults? Applying science to public health policy.

PubMed

Law, Catherine

2010-12-01

Cardiovascular disease is predicted to be a leading cause of death and disability worldwide for the foreseeable future. Observational studies link a variety of prevalent early life experiences (for example, smoking in pregnancy, child poverty) to increased risk of adult cardiovascular disease. Experimental animal studies suggest plausible causal relationships. However, there has been little consideration of how to use this wealth of information to benefit children's futures. Policy documents have drawn on research evidence to recognise that early experience influences life chances, the development of human capital, and long-term health. This has led to a general policy emphasis on prevention and early intervention. To date, there are few examples of the evidence base being useful in shaping specific policies, despite potential to do so, and some examples of policy misunderstanding of science. Minor changes to the perspectives of epidemiological research in this area might greatly increase the potential for evidence-based policy.

Discrimination, Subjective Wellbeing, and the Role of Gender: A Mediation Model of LGB Minority Stress.

PubMed

Conlin, Sarah E; Douglass, Richard P; Ouch, Staci

2017-10-26

The present study examined the link between discrimination and the three components of subjective wellbeing (positive and negative affect and life satisfaction) among a cisgender sample of lesbian, gay, and bisexual (LGB) adults. Specifically, we investigated internalized homonegativity and expectations of rejection as potential mediators of the links between discrimination and subjective wellbeing among a sample of 215 participants. Results from our structural equation model demonstrated a strong, positive direct link between discrimination and negative affect. Discrimination also had small, negative indirect effects on life satisfaction through our two mediators. Interestingly, neither discrimination nor our two mediators were related with positive affect, demonstrating the need for future research to uncover potential buffers of this link. Finally, our model evidenced configural, metric, and scalar invariance, suggesting that our model applies well for both women and men. Practical implications and future directions for research are discussed.

Perception of students' intelligence malleability and potential for future success: Unfavourable beliefs towards girls.

PubMed

Verniers, Catherine; Martinot, Delphine

2015-09-01

Endorsing an entity theory of intelligence has negative effects on students' academic trajectories. Research focused on students' personal theories of intelligence has shown that girls are more likely than boys to hold an entity theory of intelligence. However, no study has examined the possibility of a gender stereotype basis for this belief. We examined whether secondary school students are knowledgeable about others' beliefs describing female students' intelligence as less malleable than male students' intelligence. A sample of 85 French ninth graders were asked to rate to what extent others perceived: (1) female or male students' intelligence as malleable and fixed; (2) female or male students as making efforts for their current achievement; and (3) female or male students as having potential for future success. Participants reported that others perceived girls' intelligence as less malleable than boys' intelligence. Moreover, the relationship between current efforts and potential for future achievement depended on the target's gender. The more hardworking a female student was perceived to be in school, the less she was considered to have potential to succeed in the future, whereas such a link was not observed for a male student. Secondary school students seem to be knowledgeable about a gender stereotype regarding intelligence and potential for academic success which is unfavourable for female students. Implications for students' academic trajectories are discussed. © 2015 The British Psychological Society.

Educational trajectories of graduate students in physics education research

NASA Astrophysics Data System (ADS)

Van Dusen, Ben; Barthelemy, Ramón S.; Henderson, Charles

2014-12-01

Physics education research (PER) is a rapidly growing area of PhD specialization. In this article we examine the trajectories that led respondents into a PER graduate program as well as their expected future trajectories. Data were collected in the form of an online survey sent to graduate students in PER. Our findings show a lack of visibility of PER as a field of study, a dominance of work at the undergraduate level, and a mismatch of future desires and expectations. We suggest that greater exposure is needed so PER is known as a field of inquiry for graduates, that more emphasis should be placed on research beyond the undergraduate level, and that there needs to be stronger communication to graduate students about potential careers.

A Community Assessmet of Biosignatures and their Frameworks

NASA Astrophysics Data System (ADS)

Domagal-Goldman, Shawn David; Nexus for Exoplanet Systems Science (NExSS)

2018-01-01

The Nexus for Exoplanet Systems Science (NExSS) organized a workshop to assess the current state of exoplanet biosignature research. Here, we review the products from that workshop. This includes: 1) a review of previously-proposed biosignatures in both the atmosphere and on the sruface of an exoplanet; 2) the need for context in assessing those biosignatures; 3) the potential for a Bayesian framework to formalize and quantify the need for context; 4) the interdisciplinary research required to advance that Bayesian framework; and 5) the missions that would search for biosignatures, including required contextual observations. Here we will revie those findings, the future path for research they suggest, and the implications they have for future missions, including both ground- and space-based missions.

Start Early to Build a Healthy Future: The Research Linking Early Learning and Health. Summary

ERIC Educational Resources Information Center

Fisher, Brooke; Hanson, Ann; Raden, Tony

2014-01-01

Every child deserves a fair chance. A chance to learn, grow, explore possibilities, persevere and achieve his or her potential. The Ounce of Prevention Fund believes that no child's potential should be limited by poor health. Good health in early childhood is an essential component of school readiness. The benefits of health and learning are…

Potential remobilization of belowground permafrost carbon under future global warming

Treesearch

P. Kuhry; E. Dorrepaal; G. Hugelius; E.A.G. Schuur; C. Tarnocai

2010-01-01

Research on permafrost carbon has dramatically increased in the past few years. A new estimate of 1672 Pg C of belowground organic carbon in the northern circumpolar permafrost region more than doubles the previous value and highlights the potential role of permafrost carbon in the Earth System. Uncertainties in this new estimate remain due to relatively few available...

Head in the Clouds: A Review of Current and Future Potential for Cloud-Enabled Pedagogies

ERIC Educational Resources Information Center

Stevenson, Michael; Hedberg, John G.

2011-01-01

This paper reviews the research on the disruptive and transformative potential of newly-emerging cloud-based pedagogies. It takes into consideration the extent to which Cloud Computing can be leveraged to disseminate and scale web-based applications within and across learning contexts. It examines ideas from current literature in Web 2.0- and…

The possible usability of three-dimensional cone beam computed dental tomography in dental research

NASA Astrophysics Data System (ADS)

Yavuz, I.; Rizal, M. F.; Kiswanjaya, B.

2017-08-01

The innovations and advantages of three-dimensional cone beam computed dental tomography (3D CBCT) are continually growing for its potential use in dental research. Imaging techniques are important for planning research in dentistry. Newly improved 3D CBCT imaging systems and accessory computer programs have recently been proven effective for use in dental research. The aim of this study is to introduce 3D CBCT and open a window for future research possibilities that should be given attention in dental research.

View of Soviet ionospheric modification research

DOE Office of Scientific and Technical Information (OSTI.GOV)

Duncan, L.M.; Showen, R.L.

1990-10-01

We have reviewed and provided a technical assessment of Soviet research of the past five to ten years in ionospheric modification by high-power radio waves. This review includes a comprehensive survey of Soviet published literature, conference proceedings, and direct discussions with the involved Soviet researchers. The current state of the art for Soviet research in this field is evaluated, identifying areas of potential breakthrough discoveries, and discussing implications of this work for emerging technologies and future applications. This assessment is divided into the categories of basic research, advanced research, and applications. Basic research is further subdivided into studies of themore » modified natural geophysical environment, nonlinear plasma physics, and polar geophysical studies. Advanced research topics include the generation of artificial ionization mirrors and high-power oblique propagation effects. A separate comparative assessment of Soviet theoretical work also is included in this analysis. Our evaluation of practical and potential applications of this research discusses the utility of ionospheric modification in creating disturbed radio wave propagation environments, and its role in current and future remote-sensing and telecommunications systems. This technical assessment does not include consideration of ionospheric modification by means other than high-power radio waves. The Soviet effort in ionospheric modification sustains theoretical and experimental research at activity levels considerably greater than that found in comparable programs in the West. Notable strengths of the Soviet program are its breadth of coverage, large numbers of scientific participation, theoretical creativity and insight, and its powerful radio wave transmitting facilities.« less

What about Place? Considering the Role of Physical Environment on Youth Imagining of Future Possible Selves

PubMed Central

Prince, Dana

2013-01-01

Identity research indicates that development of well elaborated cognitions about oneself in the future, or one's possible selves, is consequential for youths' developmental trajectories, influencing a range of social, health, and educational outcomes. Although the theory of possible selves considers the role of social contexts in identity development, the potential influence of the physical environment is understudied. At the same time, a growing body of work spanning multiple disciplines points to the salience of place, or the meaningful physical environments of people's everyday lives, as an active contributor to self-identity. Bridging these two lines of inquiry, I provide evidence to show how place-based experiences, such as belonging, aversion, and entrapment, may be internalized and encoded into possible selves, thus producing emplaced future self-concept. I suggest that for young people, visioning self in the future is inextricably bound with place; place is an active contributor both in the present development of future self-concept and in enabling young people to envision different future possible places. Implications for practice and future research include place-making interventions and conceptualizing place beyond “neighborhood effects.” PMID:25642137

Identifying and prioritising systematic review topics with public health stakeholders: A protocol for a modified Delphi study in Switzerland to inform future research agendas

PubMed Central

Mütsch, Margot; Kien, Christina; Gerhardus, Ansgar; Lhachimi, Stefan K

2017-01-01

Introduction The Cochrane Collaboration aims to produce relevant and top priority evidence that responds to existing evidence gaps. Hence, research priority setting (RPS) is important to identify which potential research gaps are deemed most important. Moreover, RPS supports future health research to conform both health and health evidence needs. However, studies that are prioritising systematic review topics in public health are surprisingly rare. Therefore, to inform the research agenda of Cochrane Public Health Europe (CPHE), we introduce the protocol of a priority setting study on systematic review topics in several European countries, which is conceptualised as pilot. Methods and analysis We will conduct a two-round modified Delphi study in Switzerland, incorporating an anonymous web-based questionnaire, to assess which topics should be prioritised for systematic reviews in public health. In the first Delphi round public health stakeholders will suggest relevant assessment criteria and potential priority topics. In the second Delphi round the participants indicate their (dis)agreement to the aggregated results of the first round and rate the potential review topics with the predetermined criteria on a four-point Likert scale. As we invite a wide variety of stakeholders we will compare the results between the different stakeholder groups. Ethics and dissemination We have received ethical approval from the ethical board of the University of Bremen, Germany (principal investigation is conducted at the University of Bremen) and a certificate of non-objection from the Canton of Zurich, Switzerland (fieldwork will be conducted in Switzerland). The results of this study will be further disseminated through peer reviewed publication and will support systematic review author groups (i.a. CPHE) to improve the relevance of the groups´ future review work. Finally, the proposed priority setting study can be used as a framework by other systematic review groups when conducting a priority setting study in a different context. PMID:28780546

A review of contrast pattern based data mining

NASA Astrophysics Data System (ADS)

Zhu, Shiwei; Ju, Meilong; Yu, Junfeng; Cai, Binlei; Wang, Aiping

2015-07-01

Contrast pattern based data mining is concerned with the mining of patterns and models that contrast two or more datasets. Contrast patterns can describe similarities or differences between the datasets. They represent strong contrast knowledge and have been shown to be very successful for constructing accurate and robust clusters and classifiers. The increasing use of contrast pattern data mining has initiated a great deal of research and development attempts in the field of data mining. A comprehensive revision on the existing contrast pattern based data mining research is given in this paper. They are generally categorized into background and representation, definitions and mining algorithms, contrast pattern based classification, clustering, and other applications, the research trends in future. The primary of this paper is to server as a glossary for interested researchers to have an overall picture on the current contrast based data mining development and identify their potential research direction to future investigation.

Neuroscience in Nigeria: the past, the present and the future.

PubMed

Balogun, Wasiu Gbolahan; Cobham, Ansa Emmanuel; Amin, Abdulbasit

2018-04-01

The science of the brain and nervous system cuts across almost all aspects of human life and is one of the fastest growing scientific fields worldwide. This necessitates the demand for pragmatic investment by all nations to ensure improved education and quality of research in Neurosciences. Although obvious efforts are being made in advancing the field in developed societies, there is limited data addressing the state of neuroscience in sub-Saharan Africa. Here, we review the state of neuroscience development in Nigeria, Africa's most populous country and its largest economy, critically evaluating the history, the current situation and future projections. This review specifically addresses trends in clinical and basic neuroscience research and education. We conclude by highlighting potentially helpful strategies that will catalyse development in neuroscience education and research in Nigeria, among which are an increase in research funding, provision of tools and equipment for training and research, and upgrading of the infrastructure at hand.

Planning for the future workforce in hematology research

PubMed Central

Abkowitz, Janis L.; Coller, Barry S.; DiMichele, Donna M.

2015-01-01

The medical research and training enterprise in the United States is complex in both its scope and implementation. Accordingly, adaptations to the associated workforce needs present particular challenges. This is particularly true for maintaining or expanding national needs for physician-scientists where training resource requirements and competitive transitional milestones are substantial. For the individual, these phenomena can produce financial burden, prolong the career trajectory, and significantly influence career pathways. Hence, when national data suggest that future medical research needs in a scientific area may be met in a less than optimal manner, strategies to expand research and training capacity must follow. This article defines such an exigency for research and training in nonneoplastic hematology and presents potential strategies for addressing these critical workforce needs. The considerations presented herein reflect a summary of the discussions presented at 2 workshops cosponsored by the National Heart, Lung, and Blood Institute and the American Society of Hematology. PMID:25758827

Planning for the future workforce in hematology research.

PubMed

Hoots, W Keith; Abkowitz, Janis L; Coller, Barry S; DiMichele, Donna M

2015-04-30

The medical research and training enterprise in the United States is complex in both its scope and implementation. Accordingly, adaptations to the associated workforce needs present particular challenges. This is particularly true for maintaining or expanding national needs for physician-scientists where training resource requirements and competitive transitional milestones are substantial. For the individual, these phenomena can produce financial burden, prolong the career trajectory, and significantly influence career pathways. Hence, when national data suggest that future medical research needs in a scientific area may be met in a less than optimal manner, strategies to expand research and training capacity must follow. This article defines such an exigency for research and training in nonneoplastic hematology and presents potential strategies for addressing these critical workforce needs. The considerations presented herein reflect a summary of the discussions presented at 2 workshops cosponsored by the National Heart, Lung, and Blood Institute and the American Society of Hematology.

Virtual Reality: An Overview.

ERIC Educational Resources Information Center

Franchi, Jorge

1994-01-01

Highlights of this overview of virtual reality include optics; interface devices; virtual worlds; potential applications, including medicine and archaeology; problems, including costs; current research and development; future possibilities; and a listing of vendors and suppliers of virtual reality products. (Contains 11 references.) (LRW)

Fostering the future with forages

USDA-ARS?s Scientific Manuscript database

Sustainability of agriculture requires innovation and development of systems with high potential to optimize productivity and environmental quality. An ARS scientist in the Plant Science Research Unit in Raleigh NC summarized the multitude of ecosystem services provided by forages, and the potentia...

An Analysis of Information Structure and Optimal Transfer Pricing decision Rules for Decentralized Firms

DTIC Science & Technology

1980-12-01

Inventories and Work Force, Prentice-Hall, Englewood Cliffs, New Jersey (1960). Horngren , C. T. Cost Accounting : A Managerial Emphasis, Fourth Edition...achieved/received by virtue of AFIT performing the research. Can you estimate what this research would have cost if it had been accomplished under...future potential, or other value of this research. Please use the bottom part of this questionnaire for your statement( s ). NAME GRADE POSITION

Indium phosphide space solar cell research: Where we are and where we are going

NASA Technical Reports Server (NTRS)

Jain, R. K.; Flood, D. J.; Weinberg, Irving

1995-01-01

Indium phosphide is considered to be a strong contender for many photovoltaic space applications because of its radiation resistance and its potential for high efficiency. An overview of recent progress is presented, and possible future research directions for indium phosphide space solar cells are discussed. The topics considered include radiation damage studies and space flight experiments.

Microbiological Research Under the Nagoya Protocol: Facts and Fiction.

PubMed

Overmann, Jörg; Scholz, Amber Hartman

2017-02-01

The Nagoya Protocol is based on concepts of biological diversity that are hardly applicable to microorganisms. Because of this incongruence, the Nagoya Protocol threatens future microbial research, potentially defeating its original purpose. Countries with appropriate regulations can promote science and their bioeconomy through international collaboration and simultaneously gain a competitive advantage. Copyright © 2016 Elsevier Ltd. All rights reserved.

The head injured adolescent: a case report and review of the issues.

PubMed

Reiter, S; Kutcher, S P

1990-11-01

Closed head injuries in adolescents are a common problem with potentially disastrous consequences to multiple areas of functioning. Through a case presentation and literature review, this paper considers treatment issues and research applications in an adolescent population with closed head injuries. Suggestions for understanding the symptom constellations are made and directions for future research and service delivery are given.

New KRAS Antibodies Available | Office of Cancer Clinical Proteomics Research

Cancer.gov

Researchers estimate that approximately 30% of all human cancers are driven by RAS oncogenes. Mutated RAS genes are responsible for making RAS proteins that support cancer development. While anti-RAS therapies may have potential clinical benefit, researchers yet do not understand how the four RAS protein isoforms, KRAS4A, KRAS4B, HRAS, and NRAS, drive malignant phenotypes. Well-characterized and defined reagents like antibodies are central to reproducibility in biomedical research and necessary for future RAS studies.

Interstellar Propulsion Research Within NASA

NASA Technical Reports Server (NTRS)

Johnson, Les; Cook, Stephen (Technical Monitor)

2001-01-01

NASA is actively conducting advanced propulsion research and technology development in various in-space transportation technologies with potential application to interstellar missions and precursors. Within the last few years, interest in the scientific community in interstellar missions as well as outer heliospheric missions, which could function as interstellar precursor missions, has increased. A mission definition team was charted by NASA to define such a precursor, The Interstellar Probe, which resulted in a prioritization of relatively near-term transportation technologies to support its potential implementation. In addition, the goal of finding and ultimately imaging extra solar planets has raised the issue of our complete inability to mount an expedition to such as planet, should one be found. Even contemplating such a mission with today's technology is a stretch of the imagination. However, there are several propulsion concepts, based on known physics, that have promise to enable interstellar exploration in the future. NASA is making small, incremental investments in some key advanced propulsion technologies in an effort to advance their state-of-the-art in support potential future mission needs. These technologies, and their relative maturity, are described.

Exoskeleton robots for upper-limb rehabilitation: state of the art and future prospects.

PubMed

Lo, Ho Shing; Xie, Sheng Quan

2012-04-01

Current health services are struggling to provide optimal rehabilitation therapy to victims of stroke. This has motivated researchers to explore the use of robotic devices to provide rehabilitation therapy for strokepatients. This paper reviews the recent progress of upper limb exoskeleton robots for rehabilitation treatment of patients with neuromuscular disorders. Firstly, a brief introduction to rehabilitation robots will be given along with examples of existing commercial devices. The advancements in upper limb exoskeleton technology and the fundamental challenges in developing these devices are described. Potential areas for future research are discussed. Copyright © 2011 IPEM. Published by Elsevier Ltd. All rights reserved.

What tourist business managers must learn from disaster research.

PubMed

Drabek, Thomas E

2016-01-01

Death and social disruption caused by disasters of varying forms will continue to increase in the future. So too will the impacts on tourism, now one of the fastest growing and largest sectors of the worldwide economy. Tourist business managers must implement evidence-based preparedness activities to enhance the survival potential and future profitability of their firms. Drawing upon recent research studies of the tourist industry during times of crisis and the broad social science knowledge base regarding human responses to disaster, seven key lessons are described. Emergency managers must facilitate the incorporation of these lessons into the culture of tourist business managers.

Evidence base and future research directions in the management of low back pain

PubMed Central

Abbott, Allan

2016-01-01

Low back pain (LBP) is a prevalent and costly condition. Awareness of valid and reliable patient history taking, physical examination and clinical testing is important for diagnostic accuracy. Stratified care which targets treatment to patient subgroups based on key characteristics is reliant upon accurate diagnostics. Models of stratified care that can potentially improve treatment effects include prognostic risk profiling for persistent LBP, likely response to specific treatment based on clinical prediction models or suspected underlying causal mechanisms. The focus of this editorial is to highlight current research status and future directions for LBP diagnostics and stratified care. PMID:27004162

Jet Fuel Thermal Stability

NASA Technical Reports Server (NTRS)

Taylor, W. F. (Editor)

1979-01-01

Various aspects of the thermal stability problem associated with the use of broadened-specification and nonpetroleum-derived turbine fuels are addressed. The state of the art is reviewed and the status of the research being conducted at various laboratories is presented. Discussions among representatives from universities, refineries, engine and airframe manufacturers, airlines, the Government, and others are presented along with conclusions and both broad and specific recommendations for future stability research and development. It is concluded that significant additional effort is required to cope with the fuel stability problems which will be associated with the potentially poorer quality fuels of the future such as broadened specification petroleum fuels or fuels produced from synthetic sources.

Evaluating and operationalizing unmanned aircraft for wildland fire use

NASA Astrophysics Data System (ADS)

Watts, A.

2015-12-01

Many potential uses of unmanned aircraft systems (UAS) related to wildland fire research and operations have been demonstrated, but the vast majority of these have been proof-of-concept or one-time flights. Scientists, practitioners, and firefighting agencies look forward to the widespread adoption of this powerful technology and its regular use. Similarly, the UAS industry awaits opportunities for commercialization. Our collaboration brings together UAS industry, research and management agencies, and universities in the USA and Canada to investigate the perceived effectiveness of UAS for wildland fire use, and the factors affecting their commercial-scale employment. Our current and future activities include market research, training and technology transfer, and deployment of UAS over fires to promote development of sensors as well as their safe integration into fire operations. We will present initial results, and as a part of our presentation we also invite participation of the AGU community for planned future project phases. We anticipate that the outcomes of our work will be useful to potential users who are unfamiliar with UAS, and to researchers and practitioners with experience or an interest in their use in fire and related natural-resource disciplines.

Gendered Social Capital in a Johannesburg Township

PubMed Central

Myroniuk, Tyler W.

2016-01-01

Social capital research rarely takes a gendered approach. This article explores how black women and men from a marginalized community in Johannesburg, South Africa, rely on family, friends, and community members to survive and strategize for the future by utilizing social capital. The results from 30 semi-structured interviews and ego network mapping illustrate that gender moderates the type of social capital used and benefits associated with bonding and bridging social capital in important ways. This research builds upon knowledge of gendered advantages and disadvantages in social networks and informs researchers how women and men survive in pervasive poverty. I posit that identifying potential sources of support is an important consideration within social capital or any network research because the prospect of receiving assistance in the future undoubtedly alters the development of these individuals’ livelihood strategies. PMID:27773948

Biosurfactant-induced remediation of contaminated marine sediments: Current knowledge and future perspectives.

PubMed

Dell'Anno, F; Sansone, C; Ianora, A; Dell'Anno, A

2018-06-01

The contamination of marine sediments is widespread in coastal regions of the world and represents a major concern for the potential detrimental consequences on ecosystems' health and provision of goods and services for human wellbeing. Thus, there is an urgent need to find sustainable and eco-compatible solutions for the remediation of contaminated sediments. Bioremediation is a low cost and environmental-friendly strategy with a high potential for the remediation of contaminated marine sediments. Here we review the potential application of biosurfactants produced by microbial taxa for the remediation of contaminated marine sediments and we discuss future research needs to develop efficient and eco-sustainable biosurfactant-based strategies for the recovery of contaminated marine sediments, in view of large-scale applications. Copyright © 2018 Elsevier Ltd. All rights reserved.

Mechanism of deoxynivalenol effects on the reproductive system and fetus malformation: Current status and future challenges.

PubMed

Yu, Miao; Chen, Liangkai; Peng, Zhao; Nüssler, Andreas K; Wu, Qinghua; Liu, Liegang; Yang, Wei

2017-06-01

Deoxynivalenol (DON) is a toxic fungal secondary metabolite produced by molds of the Fusarium genus, and it is known to cause a spectrum of diseases both in humans and animals, such as emesis, diarrhea, anorexia, immunotoxicity, hematological disorders, impairment of maternal reproduction, and fetal development. The recently revealed teratogenic potential of DON has received much attention. In various animal models, it has been shown that DON led to skeletal deformities of the fetus. However, the underlying mechanisms are not yet fully understood, and toxicological data are also scarce. Several animal research studies highlight the potential link between morphological abnormalities and changes of autophagy in the reproductive system. Because autophagy is involved in fetal development, maintenance of placental function, and bone remodeling, this mechanism has become a high priority for future research. The general aim of the present review is to deliver a comprehensive overview of the current state of knowledge of DON-induced reproductive toxicity in different animal models and to provide some prospective ideas for further research. The focus of the current review is to summarize toxic and negative effects of DON exposure on the reproductive system and the potential underlying molecular mechanisms in various animal models. Copyright © 2017 Elsevier B.V. All rights reserved.

Meeting report: international workshop on endocrine disruptors: exposure and potential impact on consumers health.

PubMed

Rousselle, C; Ormsby, J N; Schaefer, B; Lampen, A; Platzek, T; Hirsch-Ernst, K; Warholm, M; Oskarsson, A; Nielsen, P J; Holmer, M L; Emond, C

2013-02-01

The French Agency for Food, Environmental and Occupational Health and Safety (Anses) hosted a two-day workshop on Endocrine Disruptors: Exposure and Potential Impact on Consumers Health, bringing together participants from international organizations, academia, research institutes and from German, Swedish, Danish and French governmental agencies. The main objective of the workshop was to share knowledge and experiences on endocrine disruptors (ED) exposure and potential impact on consumers' health, to identify current risk assessment practices and knowledge gaps and issue recommendations on research needs and future collaboration. The following topics were reviewed: (1) Definition of ED, (2) endpoints to be considered for Risk assessment (RA) of ED, (3) non-monotonic dose response curves, (4) studies to be considered for RA (regulatory versus academic studies), (5) point of departure and uncertainty factors, (6) exposure assessment, (7) regulatory issues related to ED. The opinions expressed during this workshop reflect day-to-day experiences from scientists, regulators, researchers, and others from many different countries in the fields of risk assessment, and were regarded by the attendees as an important basis for further discussions. Accordingly, the participants underlined the need for more exchange in the future to share experiences and improve the methodology related to risk assessment for endocrine disrupters. Copyright © 2012 Elsevier Inc. All rights reserved.

Is ambiguity tolerance malleable? Experimental evidence with potential implications for future research.

PubMed

Endres, Megan L; Camp, Richaurd; Milner, Morgan

2015-01-01

We conducted two research studies to address the malleability of tolerance of ambiguity (TA) by manipulating situational ambiguity. Students participated in a semester-end assessment of their management skills (n = 306). In Study 1, students in low and moderate ambiguity conditions had significantly higher post-experiment TA, more positive change in self-efficacy, and marginally higher faculty ratings. In Study 2, a control group (n = 103) did not participate in the assessment and was established for comparison to the first study results. The Study 2 students reported TA significantly lower than Study 1 students in the low and moderate ambiguity conditions. The control group TA was not significantly different from that of the Study 1 high ambiguity condition. This further suggested TA's situational malleability, as those who had controlled access to structured information appeared to have increased their TA over that observed in the other two groups. These results suggest that TA may be malleable. We review the relevant literature, offer hypotheses, report our analyses and findings, and then propose future research, and potential prescriptive applications in such areas as management development, assessment, and decision-making.

Playing the Long Game: Considering the Future of Augmentative and Alternative Communication Research and Service.

PubMed

Reichle, Joe; Drager, Kathryn; Caron, Jessica; Parker-McGowan, Quannah

2016-11-01

This article examines the growth of aided augmentative and alternative communication (AAC) in providing support to children and youth with significant communication needs. Addressing current trends and offering a discussion of needs and probable future advances is framed around five guiding principles initially introduced by Williams, Krezman, and McNaughton. These include: (1) communication is a basic right and the use of AAC, especially at a young age, can help individuals realize their communicative potential; (2) AAC, like traditional communication, requires it to be fluid with the ability to adapt to different environments and needs; (3) AAC must be individualized and appropriate for each user; (4) AAC must support full participation in society across all ages and interests; and (5) individuals who use AAC have the right to be involved in all aspects of research, development, and intervention. In each of these areas current advances, needs, and future predictions are offered and discussed in terms of researchers' and practitioners' efforts to a continued upward trajectory of research and translational service delivery. Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Comprehensive Environmental Assessment Applied to ...

EPA Pesticide Factsheets

In September 2013, EPA announced the availability of the final report, Comprehensive Environmental Assessment Applied to Multiwalled Carbon Nanotube Flame-Retardant Coatings in Upholstery Textiles: A Case Study Presenting Priority Research Gaps for Future Risk Assessments. This final report presents a case study of multiwalled carbon nanotubes (MWCNTs); it focuses on the specific example of MWCNTs as used in flame-retardant coatings applied to upholstery textiles. This case study is organized around the comprehensive environmental assessment (CEA) framework, which structures available information pertaining to the product life cycle, environmental transport and fate, exposure-dose in receptors (i.e., humans, ecological populations, and the environment), and potential impacts in these receptors. A group of experts representing multiple disciplines and multiple sector perspectives used an earlier draft of the case study in conjunction with a structured workshop process to identify and prioritize research gaps that, if pursued, could inform future MWCNT assessment efforts. The final report is not a health, risk, or exposure assessment and as such does not draw conclusions about potential risks, or present an exhaustive review of the literature. Rather, it presents the MWCNT research priorities that experts identified in this application of CEA in order to aid research planning throughout the scientific community. The outcomes of these research efforts may subsequ

Projecting future grassland performance in the Greater Platte River Basin to assess sustainability for potential biofuel feedstock areas

NASA Astrophysics Data System (ADS)

Gu, Y.; Wylie, B. K.; Phuyal, K.

2012-12-01

In previous studies, we used vegetation condition information from archival records of satellite data (i.e., 10-year time series of Normalized Difference Vegetation Index (NDVI) data), site geophysical and biophysical features (e.g., elevation, slope and aspect, and soils), and weather and climate drivers to build ecosystem performance (EP) models to dynamically monitor EP (DMEP) in the Greater Platte River Basin (GPRB). Ecosystem performance is a surrogate approach for measuring ecosystem productivity. We estimated ecosystem site potentials (i.e., long-term ecosystem productivities), weather-based expected EP (EEP), and rangeland conditions based on these EP models. Validation of the EP results using ground observations (e.g., percentage of bare soil, LANDFIRE maps, stocking rate, and crop yield data) demonstrated the reliability of these EP models. We used this DMEP method to identify grasslands that are potentially suitable for cellulosic biofuel feedstock (e.g., switchgrass) development in the GPRB. The objectives of this study are to (1) project the future grassland EP; (2) assess the changes and trends of the future EP; and (3) examine the future sustainability of the identified biofuel feedstock areas in the GPRB. We used the EP models and future climate projections to estimate future (e.g., 2050 and 2099) climate-based projections of grassland performance in the GPRB. The future climate data were derived from the National Center for Atmospheric Research (NCAR) Community Climate System Model 3.0 (CCSM3) "SRES A1B" (a "middle" emissions path) obtained from the "Bias Corrected and Downscaled WCRP CMIP3 Climate Projections" archive (http://gdo-dcp.ucllnl.org/downscaled_cmip3_projections). Results show that, under climate scenario A1B, the potential biofuel feedstock areas in the more mesic Eastern part of the GPRB will remain productive in the future (the spatially averaged EPs for these areas are 3335 kg ha-1 year-1, 3355 kg ha-1 year-1, and 3341 kg ha-1 year-1 for the site potential, the 2050 EEP, and the 2099 EEP, respectively). Therefore, the identified potential biofuel feedstock areas will continue to be sustainable for future biofuel development. On the other hand, the identified non-biofuel grasslands in the drier Western part of the GPRB would be expected to stay unproductive, with a slight decline in the EP trend in the future (spatially averaged EPs are 1983 kg ha-1 year-1, 1977 kg ha-1 year-1, and 1964 kg ha-1 year-1 for the site potential, the 2050 EEP, and the 2099 EEP, respectively). Thus, these areas will continue to be unsuitable for biofuel feedstock development in the future. The resulting future grassland EEP maps can be used as a reference by land managers to assess the future sustainability and feasibility of the potential biofuel feedstock areas.

Modeling the Energy Use of a Connected and Automated Transportation System (Poster)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gonder, J.; Brown, A.

Early research points to large potential impacts of connected and automated vehicles (CAVs) on transportation energy use - dramatic savings, increased use, or anything in between. Due to a lack of suitable data and integrated modeling tools to explore these complex future systems, analyses to date have relied on simple combinations of isolated effects. This poster proposes a framework for modeling the potential energy implications from increasing penetration of CAV technologies and for assessing technology and policy options to steer them toward favorable energy outcomes. Current CAV modeling challenges include estimating behavior change, understanding potential vehicle-to-vehicle interactions, and assessing trafficmore » flow and vehicle use under different automation scenarios. To bridge these gaps and develop a picture of potential future automated systems, NREL is integrating existing modeling capabilities with additional tools and data inputs to create a more fully integrated CAV assessment toolkit.« less

A Critical Review of Available Retrievable Inferior Vena Cava Filters and Future Directions

PubMed Central

Montgomery, Jennifer P.; Kaufman, John A.

2016-01-01

Inferior vena cava filters have been placed in patients for decades for protection against pulmonary embolism. The widespread use of filters has dramatically increased owing at least in part to the approval of retrievable vena cava filters. Retrievable filters have the potential to protect against pulmonary embolism and then be retrieved once no longer needed to avoid potential long-term complications. There are several retrievable vena cava filters available for use. This article discusses the different filter designs as well as the published data on these available filters. When selecting a filter for use, it is important to consider the potential short-term complications and the filters' window for retrieval. Understanding potential long-term complications is also critical, as these devices are approved for permanent placement and many filters are not retrieved. Finally, this article will address research into new designs that may be the future of vena cava filtration. PMID:27247475

A Critical Review of Available Retrievable Inferior Vena Cava Filters and Future Directions.

PubMed

Montgomery, Jennifer P; Kaufman, John A

2016-06-01

Inferior vena cava filters have been placed in patients for decades for protection against pulmonary embolism. The widespread use of filters has dramatically increased owing at least in part to the approval of retrievable vena cava filters. Retrievable filters have the potential to protect against pulmonary embolism and then be retrieved once no longer needed to avoid potential long-term complications. There are several retrievable vena cava filters available for use. This article discusses the different filter designs as well as the published data on these available filters. When selecting a filter for use, it is important to consider the potential short-term complications and the filters' window for retrieval. Understanding potential long-term complications is also critical, as these devices are approved for permanent placement and many filters are not retrieved. Finally, this article will address research into new designs that may be the future of vena cava filtration.

Crop resources. [18 papers

DOE Office of Scientific and Technical Information (OSTI.GOV)

Seigler, D.S.

Eighteen papers originally presented as a symposium on Crop Resources at the 17th annual meeting of the Society for Economic Botany in Urbana, Illinois, June 13 to 17, 1976 comprise this book. The papers are: Potential Wealth in New Crops: Research and Development, L. H. Princen; Plant Introductions--A Source of New Crops, George A. White; Nonfood Uses for Commercial Vegetable Oil Crops, E. H. Pryde; New Industrial Potentials for Carbohydrates, F. H. Otey; The Current Importance of Plants as a Source of Drugs, Norman R. Farnsworth; Potentials for Development of Wild Plants as Row Crops for Use by Man, Arnoldmore » Krochmal and Connie Krochmal; Recent Evidence in Support of the Tropical Origin of New World Crops, C. Earle Smith, Jr.; Requirements for a Green Revolution, G. F. Sprague; How Green Can a Revolution Be, Jack R. Harlan; Increasing Cereal Yields: Evolution under Domestication, J. M. J. de Wet; Hevea Rubber: Past and Future, Ernest P. Imle; Horseradish--Problems and Research in Illinois, A. M. Rhodes; Dioscorea--The Pill Crop, Norman Applezweig; Plant Derivatives for Insect Control, Robert L. Metcalf; Evolutionary Dynamics of Sorghum Domestication, J. M. J. de Wet and Y. Shecter; The Origin and Future of Wheat, E. R. Sears; Current Thoughts on Origins, Present Status, and Future of Soybeans, T. Hymowitz and C. A. Newell; and The Origin of Corn--Studies of the Last Hundred Years, Garrison Wilkes. (MCW)« less

The Neural Systems of Forgiveness: An Evolutionary Psychological Perspective

PubMed Central

Billingsley, Joseph; Losin, Elizabeth A. R.

2017-01-01

Evolution-minded researchers posit that the suite of human cognitive adaptations may include forgiveness systems. According to these researchers, forgiveness systems regulate interpersonal motivation toward a transgressor in the wake of harm by weighing multiple factors that influence both the potential gains of future interaction with the transgressor and the likelihood of future harm. Although behavioral research generally supports this evolutionary model of forgiveness, the model’s claims have not been examined with available neuroscience specifically in mind, nor has recent neuroscientific research on forgiveness generally considered the evolutionary literature. The current review aims to help bridge this gap by using evolutionary psychology and cognitive neuroscience to mutually inform and interrogate one another. We briefly summarize the evolutionary research on forgiveness, then review recent neuroscientific findings on forgiveness in light of the evolutionary model. We emphasize neuroscientific research that links desire for vengeance to reward-based areas of the brain, that singles out prefrontal areas likely associated with inhibition of vengeful feelings, and that correlates the activity of a theory-of-mind network with assessments of the intentions and blameworthiness of those who commit harm. In addition, we identify gaps in the existing neuroscientific literature, and propose future research directions that might address them, at least in part. PMID:28539904

Tea, talk and technology: patient and public involvement to improve connected health 'wearables' research in dementia.

PubMed

Hassan, Lamiece; Swarbrick, Caroline; Sanders, Caroline; Parker, Angela; Machin, Matt; Tully, Mary P; Ainsworth, John

2017-01-01

There are a growing number of mobile phones, watches and electronic devices which can be worn on the body to track aspects of health and well-being, such as daily steps, sleep and exercise. Dementia researchers think that these devices could potentially be used as part of future research projects, for example to help spot changes in daily activity that may signal the early symptoms of dementia. We asked a range of older people, including people living with dementia and their carers, to participate in interactive discussions about how future participants might find using these devices as part of research projects. We also invited volunteers to borrow a range of devices to test at home, giving them further insights. Discussions revealed that people were generally supportive of this type of research, provided they gave informed consent and that devices were discreet, comfortable and easy to use. They also valued technical support and regular feedback on study progress to encourage ongoing participation. These findings were used to develop a pool of devices for researchers, with computer software and written guidance to help plan, design and support studies. Our work shows that when given the right opportunities, people who are affected by dementia can provide valuable insights that can enhance the design, delivery and quality of future research. Background Increasingly, researchers are recognising the potential for connected health devices, including smartphones and smartwatches, to generate high resolution data about patterns of daily activity and health outcomes. One aim of the Dementias Platform UK (DPUK) project is to provide researchers with a secure means to collect, collate and link data generated by such devices, thereby accelerating this type of research in the field of dementia. We aimed to involve members of the public in discussions about the acceptability and feasibility of different devices and research designs to inform the development of a device pool, software platform and written guidance to support future studies. Methods Over 30 people attended a series of interactive workshops, drop-in sessions and meetings in Greater Manchester. This included people living with dementia and cognitive impairments, carers and people without memory problems. Discussions were tailored to suit different audiences and focused on the feasibility and acceptability of a range of different wearable devices and research designs. We also invited volunteers to borrow a device to test at home, enabling further insights from hands-on interactions with devices. Results Discussions revealed that people were supportive of connected health dementia research in principle, provided they gave informed consent and that devices were discreet, comfortable and easy to use. Moreover, they recommended technical support and regular feedback on study progress to encourage ongoing participation. Conclusion By using a range of discussion-based and practical activities, we found it was feasible to involve people affected by dementia and use their insights to shape the development of a software platform and device pool to support future connected health dementia research. We recommend that researchers planning such studies in future pay adequate attention to designing suitable participant information, technical support and mechanisms of providing study progress updates to support sustained engagement from participants.

Projecting Drivers of Human Vulnerability under the Shared Socioeconomic Pathways.

PubMed

Rohat, Guillaume

2018-03-19

The Shared Socioeconomic Pathways (SSPs) are the new set of alternative futures of societal development that inform global and regional climate change research. They have the potential to foster the integration of socioeconomic scenarios within assessments of future climate-related health impacts. To date, such assessments have primarily superimposed climate scenarios on current socioeconomic conditions only. Until now, the few assessments of future health risks that employed the SSPs have focused on future human exposure-i.e., mainly future population patterns-, neglecting future human vulnerability. This paper first explores the research gaps-mainly linked to the paucity of available projections-that explain such a lack of consideration of human vulnerability under the SSPs. It then highlights the need for projections of socioeconomic variables covering the wide range of determinants of human vulnerability, available at relevant spatial and temporal scales, and accounting for local specificities through sectoral and regional extended versions of the global SSPs. Finally, this paper presents two innovative methods of obtaining and computing such socioeconomic projections under the SSPs-namely the scenario matching approach and an approach based on experts' elicitation and correlation analyses-and applies them to the case of Europe. They offer a variety of possibilities for practical application, producing projections at sub-national level of various drivers of human vulnerability such as demographic and social characteristics, urbanization, state of the environment, infrastructure, health status, and living arrangements. Both the innovative approaches presented in this paper and existing methods-such as the spatial disaggregation of existing projections and the use of sectoral models-show great potential to enhance the availability of relevant projections of determinants of human vulnerability. Assessments of future climate-related health impacts should thus rely on these methods to account for future human vulnerability-under varying levels of socioeconomic development-and to explore its influence on future health risks under different degrees of climate change.

Projecting Drivers of Human Vulnerability under the Shared Socioeconomic Pathways

PubMed Central

2018-01-01

The Shared Socioeconomic Pathways (SSPs) are the new set of alternative futures of societal development that inform global and regional climate change research. They have the potential to foster the integration of socioeconomic scenarios within assessments of future climate-related health impacts. To date, such assessments have primarily superimposed climate scenarios on current socioeconomic conditions only. Until now, the few assessments of future health risks that employed the SSPs have focused on future human exposure—i.e., mainly future population patterns—, neglecting future human vulnerability. This paper first explores the research gaps—mainly linked to the paucity of available projections—that explain such a lack of consideration of human vulnerability under the SSPs. It then highlights the need for projections of socioeconomic variables covering the wide range of determinants of human vulnerability, available at relevant spatial and temporal scales, and accounting for local specificities through sectoral and regional extended versions of the global SSPs. Finally, this paper presents two innovative methods of obtaining and computing such socioeconomic projections under the SSPs—namely the scenario matching approach and an approach based on experts’ elicitation and correlation analyses—and applies them to the case of Europe. They offer a variety of possibilities for practical application, producing projections at sub-national level of various drivers of human vulnerability such as demographic and social characteristics, urbanization, state of the environment, infrastructure, health status, and living arrangements. Both the innovative approaches presented in this paper and existing methods—such as the spatial disaggregation of existing projections and the use of sectoral models—show great potential to enhance the availability of relevant projections of determinants of human vulnerability. Assessments of future climate-related health impacts should thus rely on these methods to account for future human vulnerability—under varying levels of socioeconomic development—and to explore its influence on future health risks under different degrees of climate change. PMID:29562727

Research on curcumin: A meta-analysis of potentially malignant disorders.

PubMed

Ara, Syeda Arshiya; Mudda, Jayashree A; Lingappa, Ashok; Rao, Purushottam

2016-01-01

Turmeric has been described in ayurveda, and is referred by different names in different cultures, the active principle called curcumin or diferuloylmethane, has been shown to exhibit numerous activities. Extensive research over the last half century has revealed several important functions of curcumin. It binds to a variety of proteins and inhibits the activity of various kinases. By modulating the activation of various transcription factors, curcumin regulates the expression of inflammatory enzymes, cytokines, adhesion molecules, and cell survival proteins. Various preclinical, clinical, and animal studies suggest that curcumin has potential as an antiproliferative, anti-invasive, and antiangiogenic, as a mediator of chemoresistance, chemopreventive, and as a therapeutic agent. Thus, curcumin a spice once relegated to the kitchen shelf has moved into the clinic and may prove to be "Curecumin." Methodology and Objectives: The focus of this publication is to provide research on curcumin with scientific publications on curcumin indexed in PubMed, Google J-Gate including systematic reviews, randomized controlled trials (RCT's), observational studies, or case series reports for various potentially malignant disorders (PMD's) with special attention to studies on oral submucous fibrosis. This research will be valuable in terms of identifying opportunities to provide recommendations for future research, in terms of the populations to research, the types of interventions needed, the types of outcomes to be measured, the study designs needed, to initiate a pathway for a low-cost research plan for future clinical trials in this field with an emphasis on conducting studies in regions of the world where PMD's are prevalent. There is a lacunae for scientific review of curcumin for PMDs specially on OSMF. Appropriate therapeutic interventions are needed for the initial, intermediate, and advanced stages of the disease. High-quality RCTs should be initiated.

I PLAY AT WORK—ten principles for transforming work processes through gamification

PubMed Central

Oprescu, Florin; Jones, Christian; Katsikitis, Mary

2014-01-01

Gamified workplaces could be a positive and innovative solution to addressing contemporary problems in organizations. Such problems include high levels of stress, reduced sense of community, reduced loyalty and rapid changes in the workforce. To better prepare organizations for the future it may be helpful to identify and understand the potential advantages, disadvantages and areas for future research in relationship to the use of gamification for personal and organizational wellbeing. An analysis of research literature across disciplines in combination with expert opinion identified gamified workplaces as a promising strategy for promoting wellbeing. Furthermore, this paper proposes a set of 10 principles (I PLAY AT WORK) that may support gamification efforts. In addition to the value of mapping the present for the benefit of the future, there is also considerable value in reshaping core ideas related to the workplaces. Gamified workplaces can provide opportunities for a more vigorous and strategic inter-disciplinary research agenda that can stimulate investments in the area. PMID:24523704

Diagnosis of borderline personality disorder in China: current status and future directions.

PubMed

Zhong, Jie; Leung, Freedom

2009-02-01

This paper reviews the current status and future directions of borderline personality disorder (BPD) research in China. Although the committee of the third version of the Chinese Classification of Mental Disorders (CCMD-3) rejected BPD as a valid diagnostic category and instead adopted the term impulsive personality disorder (IPD), our literature review on personality disorders from 1979 to 2008 in China indicated that BPD was the most popular research topic among researchers and clinicians. Available empiric evidence on BPD in China provided preliminary support for the construct validity and clinical utility of BPD in clinical and nonclinical Chinese samples. Future studies in the following areas are suggested: 1) developing reliable assessment instruments for measuring BPD pathology in China, 2) comparing the construct validity and phenomenology of CCMD IPD and DSM BPD among Chinese patients, 3) examining potential cultural differences in symptom expression of BPD pathology among the Chinese, and 4) exploring indigenous and imported methods for treating BPD patients in China.

I PLAY AT WORK-ten principles for transforming work processes through gamification.

PubMed

Oprescu, Florin; Jones, Christian; Katsikitis, Mary

2014-01-01

Gamified workplaces could be a positive and innovative solution to addressing contemporary problems in organizations. Such problems include high levels of stress, reduced sense of community, reduced loyalty and rapid changes in the workforce. To better prepare organizations for the future it may be helpful to identify and understand the potential advantages, disadvantages and areas for future research in relationship to the use of gamification for personal and organizational wellbeing. An analysis of research literature across disciplines in combination with expert opinion identified gamified workplaces as a promising strategy for promoting wellbeing. Furthermore, this paper proposes a set of 10 principles (I PLAY AT WORK) that may support gamification efforts. In addition to the value of mapping the present for the benefit of the future, there is also considerable value in reshaping core ideas related to the workplaces. Gamified workplaces can provide opportunities for a more vigorous and strategic inter-disciplinary research agenda that can stimulate investments in the area.

Tribological Limitations in Gas Turbine Engines: A Workshop to Identify the Challenges and Set Future Directions

NASA Technical Reports Server (NTRS)

DellaCorte, Chris; Pinkus, Oscar

2000-01-01

The following report represents a compendium of selected speaker presentation materials and observations made by Prof O. Pinkus at the NASA/ASME/Industry sponsored workshop entitled "Tribological Limitations in Gas Turbine Engines" held on September 15-17, 1999 in Albany, New York. The impetus for the workshop came from the ASME's Research Committee on Tribology whose goal is to explore new tribological research topics which may become future research opportunities. Since this subject is of current interest to other industrial and government entities the conference received cosponsorship as noted above. The conference was well attended by government, industrial and academic participants. Topics discussed included current tribological issues in gas turbines as well as the potential impact (drawbacks and advantages) of future tribological technologies especially foil air bearings and magnetic beatings. It is hoped that this workshop report may serve as a starting point for continued discussions and activities in oil-free turbomachinery systems.

Tribological Limitations in Gas Turbine Engines: A Workshop to Identify the Challenges and Set Future Directions. Revised

NASA Technical Reports Server (NTRS)

DellaCorte, Chris; Pinkus, Oscar

2002-01-01

The following report represents a compendium of selected speaker presentation materials and observations made by Prof. O. Pinkus at the NASA/ASME/Industry sponsored workshop entitled "Tribological Limitations in Gas Turbine Engines" held on September 15-17, 1999 in Albany, New York. The impetus for the workshop came from the ASME's Research Committee on tribology whose goal is to explore new tribological research topics which may become future research opportunities. Since this subject is of current interest to other industrial and government entities the conference received cosponsorship as noted above. The conference was well attended by government, industrial, and academic participants. Topics discussed included current tribological issues in gas turbines as well as the potential impact (drawbacks and advantages) of future tribological technologies especially foil air bearings and magnetic bearings. It is hoped that this workshop report may serve as a starting point for continued discussions and activities in oil-free turbomachinery systems.

An assessment of global meteorological droughts based on HAPPI experiments

NASA Astrophysics Data System (ADS)

Liu, Wenbin; Sun, Fubao; Lim, Wee Ho; Zhang, Jie

2017-04-01

Droughts caused water shortages could lead to serious consequences on the socioeconomic and environmental well-being. In the context of changing climate, droughts monitoring, attributions and impact assessments have been performed using observations (e.g., Sun et al., 2012; Zhang et al., 2016) and climate model projections (e.g., Liu et al., 2016, 2017); with expectation that such scientific knowledge would feed into long-term adaptation and mitigation plans to tackle potentially unfavorable future drought impacts in a warming world. Inspired by the 2015 Paris Agreement, the HAPPI (Half a degree Additional warming, Projections, Prognosis and Impacts) experiments were set up to better inform international policymakers about the socioeconomic and environmental impacts under less severe global warming conditions. This study aims to understand the potential shift in meteorological droughts from the past into the future on a global scale. Based on the HAPPI data, we evaluate the change in drought related indices (i.e., PET/P, PDSI) from the past to the future scenarios (1.5 and 2 degrees Celsius warming). Here we present some early results (MIROC5 as demonstration) on identified hotspots and discuss the differences in severity of droughts between these warming worlds and associated consequences. References: Liu W, and Sun F, 2017. Projecting and attributing future changes of evaporative demand over China in CMIP5 climate models, Journal of Hydrometeorology, doi: 10.1175/JHM-D-16-0204.1 Liu W, and Sun F, 2016. Assessing estimates of evaporative demand in climate models using observed pan evaporation over China. Journal of Geophysical Research-Atmosphere 121, 8329-8349 Zhang J, Sun F, Xu J, Chen Y, Sang Y, -F, and Liu C, 2016. Dependence of trends in and sensitivity of drought over China (1961-2013) on potential evaporation model. Geophysical Research Letters 43, 206-213 Sun F, Roderick M, Farquhar G, 2012. Changes in the variability of global land precipitation. Geophysical Research Letters 39, L19402

Mobile user interface development for the Virginia Connected Corridors.

DOT National Transportation Integrated Search

2016-10-15

The purpose of this research and development activity was to build a mobile application with a low-distraction user interface appropriate for use in a connected vehicle (CV) environment. To realize their full potential, future CV applications will in...

An Information Technology Architecture for Pharmaceutical Research and Development

PubMed Central

Klingler, Daniel E.; Jaffe, Marvin E.

1990-01-01

Rationale for and development of an information technology architecture are presented. The architectural approach described produces a technology environment that is integrating, flexible, robust, productive, and future-oriented. Issues accompanying architecture development and potential impediments to success are discussed.

Transportation planning, policy and climate change : making the long-term connection.

DOT National Transportation Integrated Search

2011-03-01

Climate change and variability will have significant impacts on the future mobility of the population in this : country. Previous research has found that the transportation sector is not considering adaptation as a : solution to these potential impac...

Learning through Making and Maker Education

ERIC Educational Resources Information Center

Hsu, Yu-Chang; Baldwin, Sally; Ching, Yu-Hui

2017-01-01

In this paper, we provide an overview of the current efforts in maker education, supported by a review of empirical studies. Our synthesis will inform the community about learning outcomes, potential and common issues, challenges, resources, and future research direction regarding maker education.

A Review of Behavioral Conceptualizations and Treatments of Child Noncompliance.

ERIC Educational Resources Information Center

Houlihan, Daniel; And Others

1992-01-01

This review of behavioral conceptualizations and approaches to the treatment of child noncompliance includes discussion of behavioral definitions, methods of assessment, types of behavioral interventions, generalization of treatment effects, future research directions, and potential ethical concerns. (Author/JDD)

Technology R&D for space commerce

NASA Technical Reports Server (NTRS)

Sadin, Stanley R.; Christensen, Carissa B.; Steen, Robert G.

1992-01-01

The potential effects of reserach conducted by the NASA Office of Aeronautics and Space Technology, OAST, on the aerospace industry are addressed. Program elements aimed at meeting commercial needs and those aimed at meeting NASA needs which have secondary effects benefiting aerospace firms are considered. Particular attention is given to current and future NASA programs for cooperating with industry and the potential effects of OAST research on nonaerospace industries.

Drop Tower Workshop

NASA Technical Reports Server (NTRS)

Urban, David

2013-01-01

Ground based microgravity facilities are an important proving ground for space experiments, ground-based research and space hardware risk mitigation. An overview of existing platforms will be discussed with an emphasis on drop tower capabilities. The potential for extension to partial gravity conditions will be discussed. Input will be solicited from attendees for their potential to use drop towers in the future and the need for enhanced capabilities (e.g. partial gravity)

Projecting Future Heat-Related Mortality under Climate Change Scenarios: A Systematic Review

PubMed Central

Barnett, Adrian Gerard; Wang, Xiaoming; Vaneckova, Pavla; FitzGerald, Gerard; Tong, Shilu

2011-01-01

Background: Heat-related mortality is a matter of great public health concern, especially in the light of climate change. Although many studies have found associations between high temperatures and mortality, more research is needed to project the future impacts of climate change on heat-related mortality. Objectives: We conducted a systematic review of research and methods for projecting future heat-related mortality under climate change scenarios. Data sources and extraction: A literature search was conducted in August 2010, using the electronic databases PubMed, Scopus, ScienceDirect, ProQuest, and Web of Science. The search was limited to peer-reviewed journal articles published in English from January 1980 through July 2010. Data synthesis: Fourteen studies fulfilled the inclusion criteria. Most projections showed that climate change would result in a substantial increase in heat-related mortality. Projecting heat-related mortality requires understanding historical temperature–mortality relationships and considering the future changes in climate, population, and acclimatization. Further research is needed to provide a stronger theoretical framework for projections, including a better understanding of socioeconomic development, adaptation strategies, land-use patterns, air pollution, and mortality displacement. Conclusions: Scenario-based projection research will meaningfully contribute to assessing and managing the potential impacts of climate change on heat-related mortality. PMID:21816703

`You caught me off guard': Probing the futures of complex engineered nanomaterials

NASA Astrophysics Data System (ADS)

Sadowski, Jathan; Guston, David H.

2016-07-01

This paper applies principles and methods from the framework of anticipatory governance to the case of what the National Research Council calls "complex engineered nanomaterials" (CENM). This framework does not aim to generate crystal ball visions or definitive answers, but rather provides guidance for uncovering, understanding, and addressing social, ethical, environmental, and policy issues that stem from emerging technologies. Thus, in anticipation of increased CENM research, CENM products, and their different governance challenges, we aim to lay the groundwork for the anticipatory governance of CENMs by mapping out what—according to the engineers and scientists, we interviewed who are working at the research level of these CENMs—will be the main issues and themes that we need to pay attention to in the near future. The structured interviews focused on three groups of questions: (1) potential and/or actual applications and/or products from the participant's research; (2) environmental health and safety issues pertaining to both the participant's research and CENMs generally; and (3) the future of CENMs. Without a foundational understanding to build on, social scientists, policymakers, and regulatory agencies will be at a loss about how to govern CENMs before they are widely implemented in society.

Laccase applications in biofuels production: current status and future prospects.

PubMed

Kudanga, Tukayi; Le Roes-Hill, Marilize

2014-08-01

The desire to reduce dependence on the ever diminishing fossil fuel reserves coupled with the impetus towards green energy has seen increased research in biofuels as alternative sources of energy. Lignocellulose materials are one of the most promising feedstocks for advanced biofuels production. However, their utilisation is dependent on the efficient hydrolysis of polysaccharides, which in part is dependent on cost-effective and benign pretreatment of biomass to remove or modify lignin and release or expose sugars to hydrolytic enzymes. Laccase is one of the enzymes that are being investigated not only for potential use as pretreatment agents in biofuel production, mainly as a delignifying enzyme, but also as a biotechnological tool for removal of inhibitors (mainly phenolic) of subsequent enzymatic processes. The current review discusses the major advances in the application of laccase as a potential pretreatment strategy, the underlying principles as well as directions for future research in the search for better enzyme-based technologies for biofuel production. Future perspectives could include synergy between enzymes that may be required for optimal results and the adoption of the biorefinery concept in line with the move towards the global implementation of the bioeconomy strategy.

Electromembrane extraction--three-phase electrophoresis for future preparative applications.

PubMed

Gjelstad, Astrid; Pedersen-Bjergaard, Stig

2014-09-01

The purpose of this article is to discuss the principle and the future potential for electromembrane extraction (EME). EME was presented in 2006 as a totally new sample preparation technique for ionized target analytes, based on electrokinetic migration across a supported liquid membrane under the influence of an external electrical field. The principle of EME is presented, and typical performance data for EME are discussed. Most work with EME up to date has been performed with low-molecular weight pharmaceutical substances as model analytes, but the principles of EME should be developed in other directions in the future to fully explore the potential. Recent research in new directions is critically reviewed, with focus on extraction of different types of chemical and biochemical substances, new separation possibilities, new approaches, and challenges related to mass transfer and background current. The intention of this critical review is to give a flavor of EME and to stimulate into more research in the area of EME. Unlike other review articles, the current one is less comprehensive, but put more emphasis on new directions for EME. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Emotional Intelligence as a Predictor of Academic and/or Professional Success

PubMed Central

Cain, Jeff; Smith, Kelly M.

2006-01-01

The concept of “emotional intelligence” has been extensively popularized in the lay press and corporate world as individuals purport the potential ability of emotional intelligence to predict various markers of success. Emotional intelligence (EI) most commonly incorporates concepts of emotional expression and regulation, self-awareness, and empathy. The concept has been criticized by some for its loose definition and parallels to personality traits. Additionally, several limitations to the instruments used to measure emotional intelligence have been identified. This review examines the foundations of the definitions of emotional intelligence as well as existing educational research involving emotional intelligence, both within the health professions and externally. Recommendations for future research and research potential are discussed. PMID:17136189

Using Community Based Participatory Research and Human Centered Design to Address Violence-Related Health Disparities among Latino/a Youth

PubMed Central

Kia-Keating, Maryam; Capous, Diana; Liu, Sabrina; Adams, Jessica

2016-01-01

High rates of exposure to violence and other adversities among Latino/a youth contributes to health disparities. The current paper addresses the ways in which community-based participatory research (CBPR) and human centered design (HCD) can help to engage communities in dialogue and action. We present a project exemplifying how community forums, with researchers, practitioners, and key stakeholders, including youth and parents, integrated HCD strategies with a CBPR approach. Given the potential for power inequities between these groups, CBPR+HCD acted as a catalyst for reciprocal dialogue and generated potential opportunity areas for health promotion and change. Future directions are described. PMID:28207679

The use of electropalatography in the assessment and treatment of acquired motor speech disorders in adults: current knowledge and future directions.

PubMed

McAuliffe, Megan J; Ward, Elizabeth C

2006-01-01

Electropalatography (EPG) has been employed to measure speech articulation since the mid-1970s. This technique has predominately been used in experimental phonetic research and in the diagnosis and treatment of articulation disorders in children. However, there is a growing body of research employing EPG to diagnose and treat articulatory impairment associated with acquired motor speech disorder (MSD) in adults. The purpose of this paper was to (1) review the findings of studies pertaining to the assessment and treatment of MSDs in adults using EPG, (2) highlight current methodologies employed, and (3) discuss the potential limitations of EPG in the assessment and treatment of MSDs and examine directions for future applied research and treatment studies.

Stem Cell Therapy for Incontinence: Where Are We Now? What is the Realistic Potential?

PubMed Central

Dissaranan, Charuspong; Cruz, Michelle A.; Couri, Bruna M.; Goldman, Howard B.

2011-01-01

A significant number of women experience stress urinary incontinence (SUI), which greatly affects their quality of life. Recent research investigating utilization of stem cells and their derivatives for the prevention and treatment of SUI has been performed to test the effect of cell source and method of administration in several animal models of SUI. The type of stem cell, timing of optimal dose or doses after injury, mechanism of action of stem cells, and route of administration must be investigated both preclinically and clinically before stem cell therapy becomes a possible treatment for SUI, although the future of this therapy looks promising. This article reviews the progress in stem cell research for incontinence and describes areas of future work as suggested by research in other fields. PMID:21842258

The research agenda in ICU telemedicine: a statement from the Critical Care Societies Collaborative.

PubMed

Kahn, Jeremy M; Hill, Nicholas S; Lilly, Craig M; Angus, Derek C; Jacobi, Judith; Rubenfeld, Gordon D; Rothschild, Jeffrey M; Sales, Anne E; Scales, Damon C; Mathers, James A L

2011-07-01

ICU telemedicine uses audiovisual conferencing technology to provide critical care from a remote location. Research is needed to best define the optimal use of ICU telemedicine, but efforts are hindered by methodological challenges and the lack of an organized delivery approach. We convened an interdisciplinary working group to develop a research agenda in ICU telemedicine, addressing both methodological and knowledge gaps in the field. To best inform clinical decision-making and health policy, future research should be organized around a conceptual framework that enables consistent descriptions of both the study setting and the telemedicine intervention. The framework should include standardized methods for assessing the preimplementation ICU environment and describing the telemedicine program. This framework will facilitate comparisons across studies and improve generalizability by permitting context-specific interpretation. Research based on this framework should consider the multidisciplinary nature of ICU care and describe the specific program goals. Key topic areas to be addressed include the effect of ICU telemedicine on the structure, process, and outcome of critical care delivery. Ideally, future research should attempt to address causation instead of simply associations and elucidate the mechanism of action in order to determine exactly how ICU telemedicine achieves its effects. ICU telemedicine has significant potential to improve critical care delivery, but high-quality research is needed to best inform its use. We propose an agenda to advance the science of ICU telemedicine and generate research with the greatest potential to improve patient care.

The Research Agenda in ICU Telemedicine

PubMed Central

Hill, Nicholas S.; Lilly, Craig M.; Angus, Derek C.; Jacobi, Judith; Rubenfeld, Gordon D.; Rothschild, Jeffrey M.; Sales, Anne E.; Scales, Damon C.; Mathers, James A. L.

2011-01-01

ICU telemedicine uses audiovisual conferencing technology to provide critical care from a remote location. Research is needed to best define the optimal use of ICU telemedicine, but efforts are hindered by methodological challenges and the lack of an organized delivery approach. We convened an interdisciplinary working group to develop a research agenda in ICU telemedicine, addressing both methodological and knowledge gaps in the field. To best inform clinical decision-making and health policy, future research should be organized around a conceptual framework that enables consistent descriptions of both the study setting and the telemedicine intervention. The framework should include standardized methods for assessing the preimplementation ICU environment and describing the telemedicine program. This framework will facilitate comparisons across studies and improve generalizability by permitting context-specific interpretation. Research based on this framework should consider the multidisciplinary nature of ICU care and describe the specific program goals. Key topic areas to be addressed include the effect of ICU telemedicine on the structure, process, and outcome of critical care delivery. Ideally, future research should attempt to address causation instead of simply associations and elucidate the mechanism of action in order to determine exactly how ICU telemedicine achieves its effects. ICU telemedicine has significant potential to improve critical care delivery, but high-quality research is needed to best inform its use. We propose an agenda to advance the science of ICU telemedicine and generate research with the greatest potential to improve patient care. PMID:21729894

Coastal Hazards and Integration of Impacts in Local Adaptation Planning

NASA Astrophysics Data System (ADS)

Knudsen, P.; Sorensen, C.; Molgaard, M. R.; Broge, N. H.; Andersen, O. B.

2016-12-01

Data on sea and groundwater levels, precipitation, land subsidence, geology, and geotechnical soil properties are combined with information on flood and erosion protection measures to analyze water-related impacts from climate change at an exposed coastal location. Future sea extremes will have a large impact but several coupled effects in the hydrological system need to be considered as well to provide for optimal protection and mitigation efforts. For instance, the investment and maintenance costs of securing functional water and wastewater pipes are significantly reduced by incorporating knowledge about climate change. The translation of regional sea level rise evidence and projections to concrete impact measures should take into account the potentially affected stakeholders who must collaborate on common and shared adaptation solutions. Here, knowledge integration across levels of governance and between research, private and public institutions, and the local communities provides: understanding of the immediate and potential future challenges; appreciation of different stakeholder motives, business agendas, legislative constraints etc., and a common focus on how to cost-efficiently adapt to and manage impacts of climate change. By construction of a common working platform that is updated with additional data and knowledge, e.g. from future regional models or extreme events, advances in sea level research can more readily be translated into concrete and local impact measures in a way that handles uncertainties in the future climate and urban development as well as suiting the varying stakeholder needs.

Chinese villages and their sustainable future: the European Union-China-Research Project "SUCCESS".

PubMed

Dumreicher, Heidi

2008-04-01

China has 800,000 villages-one person out of seven on the globe is living in a Chinese rural settlement. Yet the global discussions about the situation in China is currently characterised by a disproportionate focus on the development of towns and until now circumstances have generally been neglected in the rural areas, where 70% of the Chinese population is still living. Within the 5 years of the SUCCESS project research, this set of actual problems has been considered and analysed under the principle of sustainability: "What to maintain?" "What to change?" were the overall research questions asked in the SUCCESS project; the researchers were looking for answers under a sustainability regime, respecting the need to raise the quality of life in the villages. Several interweaving processes were used to achieve results: the inter-disciplinary research process between many areas of expertise, the trans-disciplinary process between the researchers and the Chinese villagers, and a negotiation process that made the connection between these two processes. The introduction describes the basic sustainability definition that was orienting the whole study. The innovation lays mostly in the methodology: the inter-disciplinary research co-operation related to practice and to involving the affected communities is needed to manage the significant and growing imbalances between urban and rural areas regarding their sustainability. In the transdisciplinary work, the project developed "village future sentences" that describe the local outcome of the research as one step towards better theoretical understanding of the mechanisms that could lead to a sustainable future, and they also managed to start sustainability processes in the case study sites. The integrated approach of the project helped generating future scenarios for these villages covering all aspects of their development, including urban design issues. Out of these scenarios, the villages developed small projects that could be implemented during the research period. This work made an important impact on community thinking within these villages. However, it can also be seen as contributing to the dramatically changing development process in China, by finding a balance between traditional and contemporary approaches. In particular, the approach demonstrated a new, inter-disciplinary and trans-disciplinary negotiation processes whereby the local knowledge and the expert knowledge find common ground and outcomes. The article follows the hypothesis that only comprehensive concepts can contribute to an upgraded living standard, where living spaces and rural life should be recognised and esteemed in the future as a complement to urban lifestyles within the Chinese society. Innovative knowledge generation-such as the "systemic structure constellation" technique or the systems model approach-helped to bring out latent needs, hopes and potential of the villagers. Besides the practical usage of these implemented projects, the process leading there showed the stakeholders their own fields of action. One major impact of these projects is the visibility of the results, which is crucial for villagers' awareness, their self-confidence and their experience with a successful participation in decision-making processes. Another impact is the potential for replicating results of sustainability-oriented patterns throughout China, especially as three of the villages have been nominated official model villages. Scenarios of a sustainable future for Chinese villages were the objective of the SUCCESS project. The first condition for this future is the question whether they can persist into the future-and to picture the importance of the rural environment and living space as a relevant element of Chinese life that needs to get a better image and more attention from the authorities and from the public opinion. Therefore, the final sentence that the whole research consortium, composed of 17 scientific institutions from European Union and China, agreed upon as a common result for the SUCCESS project, is as follows: "China is composed of a rich diversity of villages with many attractive qualities and essential resources for the future growth of the whole country; we recommend that policy makers cherish the human and natural potential of the rural economy and environment so that villages provide the foundation for sustainable development of this progressive nation" [Dumreicher, H., 2006. SUCCESS-a sustainable future for Chinese villages. International Symposium "Chinese Villages and their Sustainable Future", University of Natural Resources and Applied Life Sciences, Vienna, January 16]. This sentence was used in papers that where sent to different Chinese authorities by the Chinese partners and found its way, as a sort of "unofficial Charta", towards governmental agencies at national and provincial levels. The team carried out a 5-year-research study in rural China, aiming at establishing future images under the premises of sustainability. But the basic topic that needed to be tackled with was the question whether at all those villages could persist in the coming decades of rapid development. Therefore, the first aim of the study was to establish the importance of the rural environment and living space as a basis for the future of China.

Research possibilities? No! Needs for research to make PV solar energy utilization broadly competitive

NASA Technical Reports Server (NTRS)

Wolf, M.

1982-01-01

The historical progression of efficiency improvements, cost reductions, and performance improvements in modules and photovoltaic systems are described. The potential for future improvements in photovoltaic device efficiencies and cost reductions continues as device concepts, designs, processes, and automated production capabilities mature. Additional step-function improvements can be made as today's simpler devices are replaced by more sophisticated devices.

The Space Factor--fundamental and applied research benefiting Europe's citizens and economy.

PubMed

Heppener, M

2002-08-01

Although "made in space" products are not expected to appear in the near-future, space is gaining interest as an area for industrial or applied R&D. ESA is supporting a growing number of projects involving non-space industries and other third parties. This article gives an overview of the potential of research in space to develop valuable applications on Earth.

Research Suggestions in the Design of a Global Graduate Business Program Delivered by Online Learning

ERIC Educational Resources Information Center

Puderbaugh, Amy

2015-01-01

The purpose of this paper was to examine the unique areas of concern when establishing an eLearning program in the field of global business. A survey of eLearning and a global management subject matter appears. This paper identifies potential challenges in program design and raises practical concerns for future research. [For the full proceedings,…

Collaborative modelling: the future of computational neuroscience?

PubMed

Davison, Andrew P

2012-01-01

Given the complexity of biological neural circuits and of their component cells and synapses, building and simulating robust, well-validated, detailed models increasingly surpasses the resources of an individual researcher or small research group. In this article, I will briefly review possible solutions to this problem, argue for open, collaborative modelling as the optimal solution for advancing neuroscience knowledge, and identify potential bottlenecks and possible solutions.

Agency, Isolation, and the Coming of New Technologies: Exploring "Dependency" in Coastal Communities of Newfoundland Through Participatory Research

ERIC Educational Resources Information Center

Clover, Darlene; Harris, Carol E.

2005-01-01

How does one effectively and ethically conduct research with community members who are steeped in histories of economic and social dependency, so that the people themselves take charge of their futures? This question is explored in a Canadian context as the authors study the potential of new technologies to bring hope to traditional coastal…

Radioisotope Power Systems Program: A Program Overview

NASA Technical Reports Server (NTRS)

Hamley, John A.

2016-01-01

NASA's Radioisotope Power Systems (RPS) Program continues to plan, mature research in energy conversion, and partners with the Department of Energy (DOE) to make RPS ready and available to support the exploration of the solar system in environments where the use of conventional solar or chemical power generation is impractical or impossible to meet potential future mission needs. Recent programs responsibilities include providing investment recommendations to NASA stakeholders on emerging thermoelectric and Stirling energy conversion technologies and insight on NASA investments at DOE in readying a generator for the Mars 2020 mission. This presentation provides an overview of the RPS Program content and status and the approach used to maintain the readiness of RPS to support potential future NASA missions.

Study Designs and Evaluation Models for Emergency Department Public Health Research

PubMed Central

Broderick, Kerry B.; Ranney, Megan L.; Vaca, Federico E.; D’Onofrio, Gail; Rothman, Richard E.; Rhodes, Karin V.; Becker, Bruce; Haukoos, Jason S.

2011-01-01

Public health research requires sound design and thoughtful consideration of potential biases that may influence the validity of results. It also requires careful implementation of protocols and procedures that are likely to translate from the research environment to actual clinical practice. This article is the product of a breakout session from the 2009 Academic Emergency Medicine consensus conference entitled “Public Health in the ED: Screening, Surveillance, and Intervention” and serves to describe in detail aspects of performing emergency department (ED)-based public health research, while serving as a resource for current and future researchers. In doing so, the authors describe methodologic features of study design, participant selection and retention, and measurements and analyses pertinent to public health research. In addition, a number of recommendations related to research methods and future investigations related to public health work in the ED are provided. Public health investigators are poised to make substantial contributions to this important area of research, but this will only be accomplished by employing sound research methodology in the context of rigorous program evaluation. PMID:20053232

A Hybrid Satellite-Terrestrial Approach to Aeronautical Communication Networks

NASA Technical Reports Server (NTRS)

Kerczewski, Robert J.; Chomos, Gerald J.; Griner, James H.; Mainger, Steven W.; Martzaklis, Konstantinos S.; Kachmar, Brian A.

2000-01-01

Rapid growth in air travel has been projected to continue for the foreseeable future. To maintain a safe and efficient national and global aviation system, significant advances in communications systems supporting aviation are required. Satellites will increasingly play a critical role in the aeronautical communications network. At the same time, current ground-based communications links, primarily very high frequency (VHF), will continue to be employed due to cost advantages and legacy issues. Hence a hybrid satellite-terrestrial network, or group of networks, will emerge. The increased complexity of future aeronautical communications networks dictates that system-level modeling be employed to obtain an optimal system fulfilling a majority of user needs. The NASA Glenn Research Center is investigating the current and potential future state of aeronautical communications, and is developing a simulation and modeling program to research future communications architectures for national and global aeronautical needs. This paper describes the primary requirements, the current infrastructure, and emerging trends of aeronautical communications, including a growing role for satellite communications. The need for a hybrid communications system architecture approach including both satellite and ground-based communications links is explained. Future aeronautical communication network topologies and key issues in simulation and modeling of future aeronautical communications systems are described.

ECUT: Energy Conversion and Utilization Technologies program - Biocatalysis research activity

NASA Technical Reports Server (NTRS)

Wilcox, R.

1984-01-01

The activities of the Biocatalysis Research Activity are organized into the Biocatalysis and Molecular Modeling work elements and a supporting planning and analysis function. In the Biocatalysis work element, progress is made in developing a method for stabilizing genetically engineered traits in microorganisms, refining a technique for monitoring cells that are genetically engineered, and identifying strains of fungi for highly efficient preprocessing of biomass for optimizing the efficiency of bioreactors. In the Molecular Modeling work element, a preliminary model of the behavior of enzymes is developed. A preliminary investigation of the potential for synthesizing enzymes for use in electrochemical processes is completed. Contact with industry and universities is made to define key biocatalysis technical issues and to broaden the range of potential participants in the activity. Analyses are conducted to identify and evaluate potential concepts for future research funding.

A survey on the coordination of connected and automated vehicles at intersections and merging at highway on-ramps

DOE PAGES

Rios-Torres, Jackeline; Malikopoulos, Andreas A.

2016-09-07

Connected and automated vehicles (CAVs) have the potential to improve safety by reducing and mitigating traffic accidents. They can also provide opportunities to reduce transportation energy consumption and emissions by improving traffic flow. Vehicle communication with traffic structures and traffic lights can allow individual vehicles to optimize their operation and account for unpredictable changes. This paper summarizes the developments and the research trends in coordination with the CAVs that have been reported in the literature to date. In conclusion, remaining challenges and potential future research directions are also discussed.

Ostracod (Ostracoda, Crustacea) genomics - Promises and challenges.

PubMed

Schön, Isa; Martens, Koen

2016-10-01

Ostracods are well-suited model organisms for evolutionary research. Classic genetic techniques have mostly been used for phylogenetic studies on Ostracoda and were somewhat affected by the lack of large numbers of suitable markers. Genomic methods with their huge potential have so far rarely been applied to this group of crustaceans. We provide relevant examples of genomic studies on other organisms to propose future avenues of genomic ostracod research. At the same time, we suggest solutions to the potential problems in ostracods that the application of genomic techniques might present. Copyright © 2016 Elsevier B.V. All rights reserved.

Essential Genetic and Genomic Nursing Competencies for the Oncology Nurse

PubMed Central

Jenkins, Jean

2010-01-01

Objectives To review the opportunities and possibilities for advancing oncology nursing competencies in genetic/genomics through the illustration of case scenarios in clinical care. Data Sources Literature; research reports. Conclusions Oncology nurses have the potential to influence whether or not cutting edge research discoveries are utilized at the bedside. Clinical integration of genetic/genomic information has the potential to optimize health outcomes and lengthen patient lives. Implications for Nursing Practice Oncology nurses need to include genetics/genomics in their practice in order to impact quality patient care today and for the future. PMID:21255714

Identity motives underlying desired and feared possible future selves.

PubMed

Vignoles, Vivian L; Manzi, Claudia; Regalia, Camillo; Jemmolo, Simone; Scabini, Eugenia

2008-10-01

Desired and feared possible future selves are important motivators of behavior and provide a temporal context for self-evaluation. Yet little research has examined why people desire some possible selves and fear others. In two studies, we tested the reflection of identity motives for self-esteem, efficacy, meaning, continuity, belonging, and distinctiveness in people's desired and feared possible future selves and in their possible future identity structures. As predicted, participants desired especially those possible futures in which motives for self-esteem, efficacy, meaning, and continuity would be satisfied, and they feared especially those in which the same four motives and, marginally, the motive for distinctiveness would be frustrated. Analyses supported an indirect path from belonging via self-esteem to desire and fear. Desired and feared possible future selves reflect potential satisfaction and frustration of these identity motives.

Florida long-distance travel characteristics and their potential impacts on the transportation system.

DOT National Transportation Integrated Search

2013-03-01

The overall goal of this project is to enhance the fundamental understanding of Florida long-distance travel characteristics, and to provide policy implications for long-distance transportation planning in the future. To achieve the research goal, th...

Climate change and its impacts on estuaries

EPA Science Inventory

Past, present, and future research by WED scientists in the TEP region will be described to lay the foundation for examination of potential climate change effects on estuaries and the broader coastal zone in the Pacific Northwest (PNW). Results from National Coastal Assessments,...

Metabolomics: available results, current research projects in breast cancer, and future applications.

PubMed

Claudino, Wederson Marcos; Quattrone, Alessandro; Biganzoli, Laura; Pestrin, Marta; Bertini, Ivano; Di Leo, Angelo

2007-07-01

Metabolomics is the newest "omics" science. It is a dynamic portrait of the metabolic status of living systems. Metabolomics has brought new insights on metabolic fluxes and a more comprehensive and holistic understanding of a cell's environment. This burgeoning field promises to be a potential tool to fill the gap between genotype and phenotype. As its preceding "omics" sciences (ie, genomics and proteomics), metabolomics' aim is to dredge information hidden in a sea of data. This technology permits simultaneous monitoring of many hundreds, or thousands, of macro- and small molecules, as well as functional monitoring of multiple pivotal cellular pathways. In addition, elucidation of cellular responses to molecular damage, including evolutionarily conserved inducible molecular defense systems, could be achieved with metabolomics and could lead to the discovery of new biomarkers of molecular responses to functional perturbations. If metabolomic information could be translated into diagnostic tests, it might have the potential to impact on clinical practice, and it might lead to the supplementation of traditional biomarkers of cellular integrity, cell and tissue homeostasis, and morphological alterations that result from cell damage or death. In this review the concept and characteristics of metabolomics are introduced. Main current applications of metabolomics in cancer research are reviewed, including its potential in the drug discovery field, and, last but not least, its potential impact in the field of monitoring response and toxicity to anticancer agents. In the last section, research projects ongoing at our institution and future challenges for metabolomics will be presented and briefly discussed.

Defining Safety in the Nursing Home Setting: Implications for Future Research.

PubMed

Simmons, Sandra F; Schnelle, John F; Sathe, Nila A; Slagle, Jason M; Stevenson, David G; Carlo, Maria E; McPheeters, Melissa L

2016-06-01

Currently, the Agency for Healthcare Research and Quality (AHRQ) Common Format for nursing homes (NHs) accommodates voluntary reporting for 4 adverse events: falls with injury, pressure ulcers, medication errors, and infections. In 2015, AHRQ funded a technical brief to describe the state of the science related to safety in the NH setting to inform a research agenda. Thirty-six recent systematic reviews evaluated NH safety-related interventions to address these 4 adverse events and reported mostly mixed evidence about effective approaches to ameliorate them. Furthermore, these 4 events are likely inadequate to capture safety issues that are unique to the NH setting and encompass other domains related to residents' quality of care and quality of life. Future research needs include expanding our definition of safety in the NH setting, which differs considerably from that of hospitals, to include contributing factors to adverse events as well as more resident-centered care measures. Second, future research should reflect more rigorous implementation science to include objective measures of care processes related to adverse events, intervention fidelity, and staffing resources for intervention implementation to inform broader uptake of efficacious interventions. Weaknesses in implementation contribute to the current inconclusive and mixed evidence base as well as remaining questions about what outcomes are even achievable in the NH setting, given the complexity of most resident populations. Also related to implementation, future research should determine the effects of specific staffing models on care processes related to safety outcomes. Last, future efforts should explore the potential for safety issues in other care settings for older adults, most notably dementia care within assisted living. Copyright © 2016 AMDA – The Society for Post-Acute and Long-Term Care Medicine. All rights reserved.

Integrating Antarctic Science Into Geospace System Science

NASA Astrophysics Data System (ADS)

Kelly, J. D.

2010-12-01

Addressing the scientific, technical, and sociological challenges of the future requires both detailed basic research and system based approaches to the entire geospace system from the Earth’s core, through solid Earth, ice, oceans, atmosphere, ionosphere, and magnetosphere to the Sun’s outer atmosphere and even beyond. Fully integrating Antarctic science, and fully exploiting the scientific research possibilities of the Antarctic continent through effective and efficient support infrastructure, will be a very important contribution to future success. Amongst many new facilities and programs which can and are being proposed, the Moveable Antarctic Incoherent Scatter Radar (MAISR) at McMurdo illustrates the potential for innovative future science. This poster uses some of the proposed science programs to show how the scientific community can use the data products of this facility, and how they can contribute to the development of the tools and mechanisms for proposing, executing, and utilizing such new research capabilities. In particular, incoherent scatter radars played a big role in data collection during the recent International Polar Year and plans for future extended operations, including those in Antarctica, will be discussed in the light of lessons learnt in applying observations to global modeling developments.

Progress and Future Directions in Research on the Psychosis Prodrome: A Review for Clinicians

PubMed Central

Woodberry, Kristen A; Shapiro, Daniel I; Bryant, Caitlin; Seidman, Larry J.

2016-01-01

The psychosis prodrome, or period of clinical and functional decline leading up to acute psychosis, offers a unique opportunity for identifying mechanisms of psychosis onset and testing early intervention strategies. We summarize major findings and emerging directions in prodromal research and provide recommendations for clinicians working with individuals suspected to be at high risk for psychosis. The past two decades of research have led to three major advances. First, tools and criteria have been developed that can reliably identify imminent risk for a psychotic disorder. Second, longitudinal clinical and psychobiological data from large multisite studies are strengthening individual risk assessment and offering insights into potential mechanisms of illness onset. Third, psychosocial and pharmacological interventions are demonstrating promise for delaying or preventing the onset of psychosis in help-seeking, high-risk individuals. The dynamic psychobiological processes implicated in both risk and onset of psychosis, including altered gene expression, cognitive dysfunction, inflammation, gray and white matter brain changes, and vulnerability-stress interactions suggest a wide range of potential treatment targets and strategies. The expansion of resources devoted to early intervention and prodromal research worldwide raises hope for investigating them. Future directions include identifying psychosis-specific risk and resilience factors in children, adolescents, and non-help-seeking community samples, improving study designs to test hypothesized mechanisms of change, and intervening with strategies that better engage youth, their environmental contexts, and neurodevelopmental targets to improve functional outcomes. Prospective research on putatively prodromal samples has the potential to substantially reshape our understanding of mental illness and our efforts to combat it. PMID:26954594

Transport processes in biomedical systems: a roadmap for future research directions.

PubMed

Schmid-Schönbein, Geert W; Diller, Kenneth R

2005-09-01

A workshop was convened at Bethesda, Maryland on May 5 and 6, 2004 under the sponsorship of the NSF and NIH with the objectives of identifying emerging intellectual opportunities and applications in biotransport sciences and of guiding future research in the field. Approximately 50 leading researchers in the fields of fluid, heat, and mass biotransport were presented forward-looking perspectives and discussed how to synthesize broad cross-disciplinary areas: this defined guidelines for a roadmap document. Applications were presented in the context of disease analysis and diagnosis, therapy and prevention, and for physiologic and engineered living systems. The roadmap prioritizes specific research thrusts that reflect projected impacts on intellectuals, medical, and biological advances. Several overarching themes emerged. Most central is the expanded integration of fundamental transport sciences into the understanding of living systems and the great potential of patient specific modeling in designing a broad array of medical procedures.

An Investigation Into The Viability Of Nanocrystalline Cellulose As A Packaging Material

NASA Astrophysics Data System (ADS)

Glass, John

The focus of this proposal is to identify unexplored areas of research in the field of packaging science, specifically related to the incorporation of Nanocrystalline Cellulose (NCC) as a functional material in fiber based packaging, as well as to highlight some of potential risks and unknowns in the product lifecycle. This research hypothesizes that incorporating NCC into wood fiber-based c-flute corrugated packaging medium will show a sufficient performance improvement to justify additional research. Nanomaterials, as a whole, are still being understood, including those using naturally occurring bases such as NCC. Further incremental testing with NCC will help provide a performance and safety baseline for the necessary future research prior to mass production. NCC holds great promise for the future: a commonly available, naturally occurring material that's easily recyclable and biodegradable, yet has the strength of steel. Due diligence is required for this material to come to market in a safe and sustainable manner.

Expert Panel Recommendations on Lower Urinary Tract Health of Women Across Their Life Span

PubMed Central

Losada, Liliana; Amundsen, Cindy L.; Ashton-Miller, James; Chai, Toby; Close, Clare; Damaser, Margot; DiSanto, Michael; Dmochowski, Roger; Fraser, Matthew O.; Kielb, Stephanie J.; Kuchel, George; Mueller, Elizabeth R.; Parker-Autry, Candace; Wolfe, Alan J.

2016-01-01

Abstract Urologic and kidney problems are common in women across their life span and affect their daily life, including physical activity, sexual relations, social life, and future health. Urological health in women is still understudied and the underlying mechanisms of female urological dysfunctions are not fully understood. The Society for Women's Health Research (SWHR®) recognized the need to have a roundtable discussion where researchers and clinicians would define the current state of knowledge, gaps, and recommendations for future research directions to transform women's urological health. This report summarizes the discussions, which focused on epidemiology, clinical presentation, basic science, prevention strategies, and efficacy of current therapies. Experts around the table agreed on a set of research, education, and policy recommendations that have the potential to dramatically increase awareness and improve women's urological health at all stages of life. PMID:27285829

Photoelectrochemical enzymatic biosensors.

PubMed

Zhao, Wei-Wei; Xu, Jing-Juan; Chen, Hong-Yuan

2017-06-15

Enzymatic biosensors have been valuable bioanalytical devices for analysis of diverse targets in disease diagnosis, biological and biomedical research, etc. Photoelectrochemical (PEC) bioanalysis is a recently emerged method that promptly becoming a subject of new research interests due to its attractive potential for future bioanalysis with high sensitivity and specificity. PEC enzymatic biosensors integrate the inherent sensitivities of PEC bioanalysis and the selectivity of enzymes and thus share their both advantages. Currently, PEC enzymatic biosensors have become a hot topic of significant research and the recent impetus has grown rapidly as demonstrated by increased research papers. Given the pace of advances in this area, this review will make a thorough discussion and survey on the fundamentals, sensing strategies, applications and the state of the art in PEC enzymatic biosensors, followed by future prospects based on our own opinions. We hope this work could provide an accessible introduction to PEC enzymatic biosensors for any scientist. Copyright © 2016 Elsevier B.V. All rights reserved.

Assessment of future impacts of potential climate change scenarios on aquifer recharge in continental Spain

NASA Astrophysics Data System (ADS)

Pulido-Velazquez, David; Collados-Lara, Antonio-Juan; Alcalá, Francisco J.

2017-04-01

This research proposes and applies a method to assess potential impacts of future climatic scenarios on aquifer rainfall recharge in wide and varied regions. The continental Spain territory was selected to show the application. The method requires to generate future series of climatic variables (precipitation, temperature) in the system to simulate them within a previously calibrated hydrological model for the historical data. In a previous work, Alcalá and Custodio (2014) used the atmospheric chloride mass balance (CMB) method for the spatial evaluation of average aquifer recharge by rainfall over the whole of continental Spain, by assuming long-term steady conditions of the balance variables. The distributed average CMB variables necessary to calculate recharge were estimated from available variable-length data series of variable quality and spatial coverage. The CMB variables were regionalized by ordinary kriging at the same 4976 nodes of a 10 km x 10 km grid. Two main sources of uncertainty affecting recharge estimates (given by the coefficient of variation, CV), induced by the inherent natural variability of the variables and from mapping were segregated. Based on these stationary results we define a simple empirical rainfall-recharge model. We consider that spatiotemporal variability of rainfall and temperature are the most important climatic feature and variables influencing potential aquifer recharge in natural regime. Changes in these variables can be important in the assessment of future potential impacts of climatic scenarios over spatiotemporal renewable groundwater resource. For instance, if temperature increases, actual evapotranspitration (EA) will increases reducing the available water for others groundwater balance components, including the recharge. For this reason, instead of defining an infiltration rate coefficient that relates precipitation (P) and recharge we propose to define a transformation function that allows estimating the spatial distribution of recharge (both average value and its uncertainty) from the difference in P and EA in each area. A complete analysis of potential short-term (2016-2045) future climate scenarios in continental Spain has been performed by considering different sources of uncertainty. It is based on the historical climatic data for the period 1976-2005 and the climatic models simulations (for the control [1976-2005] and future scenarios [2016-2045]) performed in the frame of the CORDEX EU project. The most pessimistic emission scenario (RCP8.5) has been considered. For the RCP8.5 scenario we have analyzed the time series generated by simulating with 5 Regional Climatic models (CCLM4-8-17, RCA4, HIRHAM5, RACMO22E, and WRF331F) nested to 4 different General Circulation Models (GCMs). Two different conceptual approaches (bias correction and delta change techniques) have been applied to generate potential future climate scenarios from these data. Different ensembles of obtained time series have been proposed to obtain more representative scenarios by considering all the simulations or only those providing better approximations to the historical statistics based on a multicriteria analysis. This was a step to analyze future potential impacts on the aquifer recharge by simulating them within a rainfall-recharge model. This research has been supported by the CGL2013-48424-C2-2-R (MINECO) and the PMAFI/06/14 (UCAM) projects.

Initial Investigation of Operational Concept Elements for NASA's NextGen-Airportal Project Research

NASA Technical Reports Server (NTRS)

Lohr, Gary; Lee, Jonathan; Poage, James L.; Tobias, Leonard

2009-01-01

The NextGen-Airportal Project is organized into three research focus areas: Safe and Efficient Surface Operations, Coordinated Arrival/Departure Operations Management, and Airportal Transition and Integration Management. The content in this document was derived from an examination of constraints and problems at airports for accommodating future increases in air traffic, and from an examination of capabilities envisioned for NextGen. The concepts are organized around categories of constraints and problems and therefore do not precisely match, but generally reflect, the research focus areas. The concepts provide a framework for defining and coordinating research activities that are, and will be, conducted by the NextGen-Airportal Project. The concepts will help the research activities function as an integrated set focused on future needs for airport operations and will aid aligning the research activities with NextGen key capabilities. The concepts are presented as concept elements with more detailed sub-elements under each concept element. For each concept element, the following topics are discussed: constraints and problems being addressed, benefit descriptions, required technology and infrastructure, and an initial list of potential research topics. Concept content will be updated and more detail added as the research progresses. The concepts are focused on enhancing airportal capacity and efficiency in a timeframe 20 to 25 years in the future, which is similar to NextGen's timeframe.

RNAi technologies in agricultural biotechnology: The Toxicology Forum 40th Annual Summer Meeting.

PubMed

Sherman, James H; Munyikwa, Tichafa; Chan, Stephen Y; Petrick, Jay S; Witwer, Kenneth W; Choudhuri, Supratim

2015-11-01

During the 40th Annual Meeting of The Toxicology Forum, the current and potential future science, regulations, and politics of agricultural biotechnology were presented and discussed. The meeting session described herein focused on the technology of RNA interference (RNAi) in agriculture. The general process by which RNAi works, currently registered RNAi-based plant traits, example RNAi-based traits in development, potential use of double stranded RNA (dsRNA) as topically applied pesticide active ingredients, research related to the safety of RNAi, biological barriers to ingested dsRNA, recent regulatory RNAi science reviews, and regulatory considerations related to the use of RNAi in agriculture were discussed. Participants generally agreed that the current regulatory framework is robust and appropriate for evaluating the safety of RNAi employed in agricultural biotechnology and were also supportive of the use of RNAi to develop improved crop traits. However, as with any emerging technology, the potential range of future products, potential future regulatory frameworks, and public acceptance of the technology will continue to evolve. As such, continuing dialogue was encouraged to promote education of consumers and science-based regulations. Copyright © 2015 Elsevier Inc. All rights reserved.

Sustainability assessment framework for scenarios – SAFS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Arushanyan, Yevgeniya, E-mail: yevgeniya.arushanyan@abe.kth.se; KTH Royal Institute of Technology, Centre for Sustainable Communications; Ekener, Elisabeth

To address current challenges regarding sustainable development and support planning for this form of development, new learning about different possible futures and their potential sustainability implications is needed. One way of facilitating this learning is by combining the futures studies and sustainability assessment (SA) research fields. This paper presents the sustainability assessment framework for scenarios (SAFS), a method developed for assessing the environmental and social risks and opportunities of future scenarios, provides guidelines for its application and demonstrates how the framework can be applied. SAFS suggests assessing environmental and social aspects using a consumption perspective and a life cycle approach,more » and provides qualitative results. SAFS does not suggest any modelling using precise data, but instead offers guidelines on how to carry out a qualitative assessment, where both the process of assessing and the outcome of the assessment are valuable and can be used as a basis for discussion. The benefits, drawbacks and potential challenges of applying SAFS are also discussed in the paper. SAFS uses systems thinking looking at future societies as a whole, considering both environmental and social consequences. This encourages researchers and decision-makers to consider the whole picture, and not just individual elements, when considering different futures. - Highlights: • The paper presents a new methodological framework for qualitative sustainability assessment of future scenarios with transformative changes. • The framework suggests qualitative assessment with consumption perspective and a life cycle approach. • The paper presents the framework and provides guidelines for its application. • The paper demonstrates on an example how the framework can be applied. • The benefits, drawbacks and challenges of the framework application and the need for further development are discussed.« less

Alignment achieved? The learning landscape and curricula in health profession education.

PubMed

Nordquist, Jonas

2016-01-01

The overall aim of this review is to map the area around the topic of the relationship between physical space and learning and to then draw further potential implications from this for the specific area of health profession education. The nature of the review is a scoping review following a 5-step-model by Arksey & O'Malley. The charting of the data has been conducted with the help of the networked learning landscape framework from Nordquist and Laing. The majority of the research studies on classroom-scale level have focused on how technology may enable active learning. There are no identified research studies on the building-scale level. Hence, the alignment of curricula and physical learning spaces has scarcely been addressed in research from other sectors. In order to 'create a field', conclusions from both case studies and research in related areas must be identified and taken into account to provide insights into health profession education. Four areas have been identified as having potential for future development in health profession education: (i) active involvement of faculty members in the early stages of physical space development; (ii) further development of the assessment strategies for evaluating how physical space impacts learning; (iii) exploration of how informal spaces are being developed in other sectors; and (iv) initiating research projects in HPE to study how informal spaces impact on students' learning. Potentially, the results of this scoping review will result in better future research questions and better-designed studies in this new and upcoming academic field of aligning physical learning spaces and curricula in health profession education. © 2015 John Wiley & Sons Ltd.

Global Foot-and-Mouth Disease Research Update and Gap Analysis: 5 - Biotherapeutics and Disinfectants.

PubMed

Robinson, L; Knight-Jones, T J D; Charleston, B; Rodriguez, L L; Gay, C G; Sumption, K J; Vosloo, W

2016-06-01

We assessed knowledge gaps in foot-and-mouth disease (FMD) research. Findings are reported in a series of papers, and in this article, we consider biotherapeutics and disinfectants. The study took the form of a literature review (2011-2015) combined with research updates collected in 2014 from 33 institutes from across the world. Findings were used to identify priority areas for future FMD research. While vaccines will remain the key immunological intervention used against FMD virus (FMDV) for the foreseeable future, it takes a few days for the immune system to respond to vaccination. In an outbreak situation, protection could potentially be provided during this period by the application of rapid, short-acting biotherapeutics, aiming either to stimulate a non-specific antiviral state in the animal or to specifically inhibit a part of the viral life cycle. Certain antiviral cytokines have been shown to promote rapid protection against FMD; however, the effects of different immune-modulators appear to vary across species in ways and for reasons that are not yet understood. Major barriers to the effective incorporation of biotherapeutics into control strategies are cost, limited understanding of their effect on subsequent immune responses to vaccines and uncertainty about their potential impact if used for disease containment. Recent research has highlighted the importance of environmental contamination in FMDV transmission. Effective disinfectants for FMDV have long been available, but research is being conducted to further develop methods for quantitatively evaluating their performance under field, or near-field, conditions. During outbreaks in South Korea in 2010 there was public concern about potential environmental contamination after the mass use of disinfectant and mass burial of culled stock; this should be considered during outbreak contingency planning. © 2016 Blackwell Verlag GmbH.

Assessing Research Interest and Capacity in Community Health Centers

PubMed Central

Bhuiya, Nazmim; Pernice, Joan; Khan, Sami M.; Sequist, Thomas D.; Tendulkar, Shalini A.

2013-01-01

Abstract Objective Community health centers (CHCs) have great potential to participate in the development of evidence‐based primary care but face obstacles to engagement in clinical translational research. Methods To understand factors associated with CHC interest in building research infrastructure, Harvard Catalyst and the Massachusetts League of Community Health Centers conducted an online survey of medical directors in all 50 Massachusetts CHC networks. Results Thirty‐two (64%) medical directors completed the survey representing 126 clinical sites. Over 80% reported that their primary care providers (PCPs) were slightly to very interested in future clinical research and that they were interested in building research infrastructure at their CHC. Frequently cited barriers to participation in research included financial issues, lack of research skills, and lack of research infrastructure. In bivariate analyses, PCP interest in future clinical research and a belief that involvement in research contributed to PCP retention were significantly associated with interest in building research infrastructure. Conclusion CHCs critical role in caring for vulnerable populations ideally positions them to raise relevant research questions and translate evidence into practice. Our findings suggest a high interest in engagement in research among CHC leadership. CTSAs have a unique opportunity to support local CHCs in this endeavor. PMID:24127928

Mechanism and active variety of allelochemicals

USGS Publications Warehouse

Peng, S.-L.; Wen, J.; Guo, Q.-F.

2004-01-01

This article summarizes allelochemicals' active variety, its potential causes and function mechanisms. Allelochemicals' activity varies with temperature, photoperiod, water and soils during natural processes, with its initial concentration, compound structure and mixed degree during functional processes, with plant accessions, tissues and maturity within-species, and with research techniques and operation processes. The prospective developmental aspects of allelopathy studies in the future are discussed. Future research should focus on: (1) to identify and purify allelochemicals more effectively, especially for agriculture, (2) the functions of allelopathy at the molecular structure level, (3) using allelopathy to explain plant species interactions, (4) allelopathy as a driving force of succession, and (5) the significance of allelopathy in the evolutionary processes.

Enhanced Molecular Sieve CO2 Removal Evaluation

NASA Technical Reports Server (NTRS)

Rose, Susan; ElSherif, Dina; MacKnight, Allen

1996-01-01

The objective of this research is to quantitatively characterize the performance of two major types of molecular sieves for two-bed regenerative carbon dioxide removal at the conditions compatible with both a spacesuit and station application. One sorbent is a zeolite-based molecular sieve that has been substantially improved over the materials used in Skylab. The second sorbent is a recently developed carbon-based molecular sieve. Both molecular sieves offer the potential of high payoff for future manned missions by reducing system complexity, weight (including consumables), and power consumption in comparison with competing concepts. The research reported here provides the technical data required to improve CO2 removal systems for regenerative life support systems for future IVA and EVA missions.

Next Generation CAD/CAM/CAE Systems

NASA Technical Reports Server (NTRS)

Noor, Ahmed K. (Compiler); Malone, John B. (Compiler)

1997-01-01

This document contains presentations from the joint UVA/NASA Workshop on Next Generation CAD/CAM/CAE Systems held at NASA Langley Research Center in Hampton, Virginia on March 18-19, 1997. The presentations focused on current capabilities and future directions of CAD/CAM/CAE systems, aerospace industry projects, and university activities related to simulation-based design. Workshop attendees represented NASA, commercial software developers, the aerospace industry, government labs, and academia. The workshop objectives were to assess the potential of emerging CAD/CAM/CAE technology for use in intelligent simulation-based design and to provide guidelines for focused future research leading to effective use of CAE systems for simulating the entire life cycle of aerospace systems.

Future Research Directions in the Positive Valence Systems: Measurement, Development, and Implications for Youth Unipolar Depression.

PubMed

Olino, Thomas M

2016-01-01

The Positive Valence Systems (PVS) have been introduced by the National Institute of Mental Health as a domain to help organize multiple constructs focusing on reward-seeking behaviors. However, the initial working model for this domain is strongly influenced by adult constructs and measures. Thus, the present review focuses on extending the PVS into a developmental context. Specifically, the review provides some hypotheses about the structure of the PVS, how PVS components may change throughout development, how family history of depression may influence PVS development, and potential means of intervening on PVS function to reduce onsets of depression. Future research needs in each of these areas are highlighted.

Didactical determinants use of information and communication technology in process of training of future specialists.

PubMed

Palamar, Borys I; Vaskivska, Halyna O; Palamar, Svitlana P

In the article the author touches upon the subject of significance of computer equipment for organization of cooperation of professor and future specialists. Such subject-subject interaction may be directed to forming of professional skills of future specialists. By using information and communication technologies in education system range of didactic tasks can be solved. Improving of process of teaching of subjects in high school, self-learning future specialists, motivating to learning and self-learning, the development of reflection in the learning process. The authors considers computer equipment as instrument for development of intellectual skills, potential and willingness of future specialists to solve communicative and communication tasks and problems on the creative basis. Based on results of researches the author comes to certain conclusions about the effectiveness of usage of computer technologies in process of teaching future specialists and their self-learning. Improper supplying of high schools with computer equipment, lack of appropriate educational programs, professors' teachers' poor knowledge and usage of computers have negative impact on organization of process of teaching disciplines in high schools. Computer equipment and ICT in general are the instruments of development of intellectual skills, potential and willingness of future specialists to solve communicative and communication tasks and problems. So, the formation of psychosocial environment of development of future specialist is multifaceted, complex and didactically important issue.

Intravenous Solutions for Exploration Missions

NASA Technical Reports Server (NTRS)

Miller, Fletcher J.; Niederhaus, Charles; Barlow, Karen; Griffin, DeVon

2007-01-01

This paper describes the intravenous (IV) fluids requirements being developed for medical care during NASA s future exploration class missions. Previous research on IV solution generation and mixing in space is summarized. The current exploration baseline mission profiles are introduced, potential medical conditions described and evaluated for fluidic needs, and operational issues assessed. We briefly introduce potential methods for generating IV fluids in microgravity. Conclusions on the recommended fluid volume requirements are presented.

Plastic and Human Health: A Micro Issue?

PubMed

Wright, Stephanie L; Kelly, Frank J

2017-06-20

Microplastics are a pollutant of environmental concern. Their presence in food destined for human consumption and in air samples has been reported. Thus, microplastic exposure via diet or inhalation could occur, the human health effects of which are unknown. The current review article draws upon cross-disciplinary scientific literature to discuss and evaluate the potential human health impacts of microplastics and outlines urgent areas for future research. Key literature up to September 2016 relating to accumulation, particle toxicity, and chemical and microbial contaminants was critically examined. Although microplastics and human health is an emerging field, complementary existing fields indicate potential particle, chemical and microbial hazards. If inhaled or ingested, microplastics may accumulate and exert localized particle toxicity by inducing or enhancing an immune response. Chemical toxicity could occur due to the localized leaching of component monomers, endogenous additives, and adsorbed environmental pollutants. Chronic exposure is anticipated to be of greater concern due to the accumulative effect that could occur. This is expected to be dose-dependent, and a robust evidence-base of exposure levels is currently lacking. Although there is potential for microplastics to impact human health, assessing current exposure levels and burdens is key. This information will guide future research into the potential mechanisms of toxicity and hence therein possible health effects.

Distributional dynamics of a vulnerable species in response to past and future climate change: a window for conservation prospects

PubMed Central

Bai, Yunjun; Wei, Xueping

2018-01-01

Background The ongoing change in climate is predicted to exert unprecedented effects on Earth’s biodiversity at all levels of organization. Biological conservation is important to prevent biodiversity loss, especially for species facing a high risk of extinction. Understanding the past responses of species to climate change is helpful for revealing response mechanisms, which will contribute to the development of effective conservation strategies in the future. Methods In this study, we modelled the distributional dynamics of a ‘Vulnerable’ species, Pseudolarix amabilis, in response to late Quaternary glacial-interglacial cycles and future 2080 climate change using an ecological niche model (MaxEnt). We also performed migration vector analysis to reveal the potential migration of the population over time. Results Historical modelling indicates that the range dynamics of P. amabilis is highly sensitive to climate change and that its long-distance dispersal ability and potential for evolutionary adaption are limited. Compared to the current climatically suitable areas for this species, future modelling showed significant migration northward towards future potential climatically suitable areas. Discussion In combination with the predicted future distribution, the mechanism revealed by the historical response suggests that this species will not be able to fully occupy the future expanded areas of suitable climate or adapt to the unsuitable climate across the future contraction regions. As a result, we suggest assisted migration as an effective supplementary means of conserving this vulnerable species in the face of the unprecedentedly rapid climate change of the 21st century. As a study case, this work highlights the significance of introducing historical perspectives while researching species conservation, especially for currently vulnerable or endangered taxa that once had a wider distribution in geological time. PMID:29362700

Distributional dynamics of a vulnerable species in response to past and future climate change: a window for conservation prospects.

PubMed

Bai, Yunjun; Wei, Xueping; Li, Xiaoqiang

2018-01-01

The ongoing change in climate is predicted to exert unprecedented effects on Earth's biodiversity at all levels of organization. Biological conservation is important to prevent biodiversity loss, especially for species facing a high risk of extinction. Understanding the past responses of species to climate change is helpful for revealing response mechanisms, which will contribute to the development of effective conservation strategies in the future. In this study, we modelled the distributional dynamics of a 'Vulnerable' species, Pseudolarix amabilis , in response to late Quaternary glacial-interglacial cycles and future 2080 climate change using an ecological niche model (MaxEnt). We also performed migration vector analysis to reveal the potential migration of the population over time. Historical modelling indicates that the range dynamics of P. amabilis is highly sensitive to climate change and that its long-distance dispersal ability and potential for evolutionary adaption are limited. Compared to the current climatically suitable areas for this species, future modelling showed significant migration northward towards future potential climatically suitable areas. In combination with the predicted future distribution, the mechanism revealed by the historical response suggests that this species will not be able to fully occupy the future expanded areas of suitable climate or adapt to the unsuitable climate across the future contraction regions. As a result, we suggest assisted migration as an effective supplementary means of conserving this vulnerable species in the face of the unprecedentedly rapid climate change of the 21st century. As a study case, this work highlights the significance of introducing historical perspectives while researching species conservation, especially for currently vulnerable or endangered taxa that once had a wider distribution in geological time.

Biomedical Polar Research Workshop Minutes

NASA Technical Reports Server (NTRS)

1990-01-01

This workshop was conducted to provide a background of NASA and National Science Foundation goals, an overview of previous and current biomedical research, and a discussion about areas of potential future joint activities. The objectives of the joint research were: (1) to develop an understanding of the physiological, psychological, and behavioral alterations and adaptations to extreme environments of the polar regions; (2) to ensure the health, well-being, and performance of humans in these environments; and (3) to promote the application of biomedical research to improve the quality of life in all environments.

Applied Information Systems Research Program (AISRP). Workshop 2: Meeting Proceedings

NASA Technical Reports Server (NTRS)

1992-01-01

The Earth and space science participants were able to see where the current research can be applied in their disciplines and computer science participants could see potential areas for future application of computer and information systems research. The Earth and Space Science research proposals for the High Performance Computing and Communications (HPCC) program were under evaluation. Therefore, this effort was not discussed at the AISRP Workshop. OSSA's other high priority area in computer science is scientific visualization, with the entire second day of the workshop devoted to it.

Organic contaminants in African aquatic systems: Current knowledge, health risks, and future research directions.

PubMed

Gwenzi, Willis; Chaukura, Nhamo

2018-04-01

Organic contaminants (OCs) are increasingly being reported in African aquatic systems, yet a critical evaluation of the literature is still lacking. The objectives of this review were to: (1) identify hotspot reservoirs, transfer pathways and ecological and human risks of OCs, (2) identify potential interventions to minimize the health risks, and (3) highlight knowledge gaps and research constraints. OCs widely reported in aquatic systems include pesticides, pharmaceuticals, plasticizers, solvents, endocrine disrupting compounds, and antimicrobial resistance genes, originating from applications in crop protection, veterinary and animal husbandry, human sanitation and hygiene, human vector and disease control. Potential hotspot reservoirs of OCs include wastewaters, on-site sanitation systems, leachates from non-engineered landfills and contaminated recharge of shallow groundwater systems. OCs could be transferred into humans via drinking of contaminated water, consumption of contaminated crops and aquatic foods, and to a lesser extent, inhalation and dermal contact. Ecological effects including intersex, estrogenicity, and acute and chronic toxicity occur in avian and aquatic species. Although the evidence base of human ecotoxicological effects of OC remains weak, pesticides have been reported in human milk, serum and sperms, pointing to potential chronic and acute toxicity and endocrine disruption. The prevalence of antimicrobials and their resistance genes could in turn lead to antimicrobial resistance in humans. The lack of OC monitoring in drinking water, coupled with over-reliance on untreated drinking water vulnerable to OC contamination predisposes humans to OC health risks. Appropriate water treatment methods, were identified, and a conceptual framework developed to minimize the ecological and human health risks. Future research directions on OC hotspot reservoirs, environmental behaviour and fate, ecotoxicology, epidemiology and interventions to minimize health risks are highlighted. However, lack of advanced analytical facilities in most African countries and other developing regions will continue to constrain OC research for now and in the foreseeable future. Copyright © 2017 Elsevier B.V. All rights reserved.

Research to inform policy on headwater streams: ongoing and future directions

EPA Science Inventory

Headwater streams are the exterior links of stream networks and represent a substantial proportion of U.S. stream miles. Alteration and loss of headwater streams have occurred without an understanding of the potential consequences to larger downstream waterbodies. Recent court ca...

A joint strategy for European rail research 2020 : towards a single European railway system

DOT National Transportation Integrated Search

2001-09-01

Innovating and harmonising products and technologies are a necessity for the rail market to deploy all its potential, and for its stakeholders to deliver cost-effective services for intermediate and final clients. Rail transport in Europe is a future...

North American Waterfowl Distributions: Analyzing Long-Term Stability and Case Studies Exploring Potential Drivers of Change

EPA Science Inventory

Knowledge about how species distributions shift through time increases basic ecological understanding, improves species management and conservation, and allows for enhanced predictions about the future. This type of research is difficult to conduct, especially for migratory wate...

Realizing the promises of marine biotechnology.

PubMed

Luiten, Esther E M; Akkerman, Ida; Koulman, Albert; Kamermans, Pauline; Reith, Hans; Barbosa, Maria J; Sipkema, Detmer; Wijffels, René H

2003-07-01

High-quality research in the field of marine biotechnology is one of the key-factors for successful innovation in exploiting the vast diversity of marine life. However, fascinating scientific research with promising results and claims on promising potential applications (e.g. for pharmaceuticals, nutritional supplements, (feed-)products for aquaculture and bioremediation solutions) is not the only factor to realise the commercial applications of marine biotechnology. What else is needed to exploit the promising potential of marine biotechnology and to create new industrial possibilities? In the study project 'Ocean Farming-Sustainable exploitation of marine organisms', we explore the possibilities of marine organisms to fulfill needs, such as safe and healthy food, industrial (raw) materials and renewable energy in a sustainable way. One of the three design groups is envisioning the future of strong land-based 'marine' market chains. Marine biotechnology is one of the foci of attention in this design group. This article provides a model of future-oriented thinking in which a variety of experts actively participate.

Exploring the Climate Change, Migration and Conflict Nexus.

PubMed

Burrows, Kate; Kinney, Patrick L

2016-04-22

The potential link between climate change, migration, and conflict has been widely discussed and is increasingly viewed by policy makers as a security issue. However, considerable uncertainty remains regarding the role that climate variability and change play among the many drivers of migration and conflict. The overall objective of this paper is to explore the potential pathways linking climate change, migration and increased risk of conflict. We review the existing literature surrounding this issue and break the problem into two components: the links between climate change and migration, and those between migration and conflict. We found a large range of views regarding the importance of climate change as a driver for increasing rates of migration and subsequently of conflict. We argue that future research should focus not only on the climate-migration-conflict pathway but also work to understand the other pathways by which climate variability and change might exacerbate conflict. We conclude by proposing five questions to help guide future research on the link between climate change, migration, and conflict.

Impacts of climate variability and future climate change on harmful algal blooms and human health.

PubMed

Moore, Stephanie K; Trainer, Vera L; Mantua, Nathan J; Parker, Micaela S; Laws, Edward A; Backer, Lorraine C; Fleming, Lora E

2008-11-07

Anthropogenically-derived increases in atmospheric greenhouse gas concentrations have been implicated in recent climate change, and are projected to substantially impact the climate on a global scale in the future. For marine and freshwater systems, increasing concentrations of greenhouse gases are expected to increase surface temperatures, lower pH, and cause changes to vertical mixing, upwelling, precipitation, and evaporation patterns. The potential consequences of these changes for harmful algal blooms (HABs) have received relatively little attention and are not well understood. Given the apparent increase in HABs around the world and the potential for greater problems as a result of climate change and ocean acidification, substantial research is needed to evaluate the direct and indirect associations between HABs, climate change, ocean acidification, and human health. This research will require a multidisciplinary approach utilizing expertise in climatology, oceanography, biology, epidemiology, and other disciplines. We review the interactions between selected patterns of large-scale climate variability and climate change, oceanic conditions, and harmful algae.

Exploring the Climate Change, Migration and Conflict Nexus

PubMed Central

Burrows, Kate; Kinney, Patrick L.

2016-01-01

The potential link between climate change, migration, and conflict has been widely discussed and is increasingly viewed by policy makers as a security issue. However, considerable uncertainty remains regarding the role that climate variability and change play among the many drivers of migration and conflict. The overall objective of this paper is to explore the potential pathways linking climate change, migration and increased risk of conflict. We review the existing literature surrounding this issue and break the problem into two components: the links between climate change and migration, and those between migration and conflict. We found a large range of views regarding the importance of climate change as a driver for increasing rates of migration and subsequently of conflict. We argue that future research should focus not only on the climate-migration-conflict pathway but also work to understand the other pathways by which climate variability and change might exacerbate conflict. We conclude by proposing five questions to help guide future research on the link between climate change, migration, and conflict. PMID:27110806

Colorectal cancer screening and adverse childhood experiences: Which adversities matter?

PubMed

Alcalá, Héctor E; Keim-Malpass, Jessica; Mitchell, Emma

2017-07-01

Adverse Childhood Experiences (ACEs) have been associated with an increased risk of a variety of diseases, including cancer. However, research has not paid enough attention to the association between ACEs and cancer screening. As such, the present study examined the association between ACEs and ever using colorectal cancer (CRC) screening, among adults age 50 and over. Analyses used the 2011 Behavioral Risk Factor Surveillance System (n=24,938) to model odds of ever engaging in CRC screening from nine different adversities. Bivariate and multivariate models were fit. In bivariate models, physical abuse, having parents that were divorced or separated, and living in a household where adults treated each other violently were associated with lower odds of engaging in CRC. In multivariate models that accounted for potential confounders, emotional and sexual abuse were each associated with higher odds of engaging in CRC. Results suggest potential pathways by which early childhood experiences can impact future health behaviors. Future research should examine this association longitudinally. Copyright © 2017 Elsevier Ltd. All rights reserved.

Biological data sciences in genome research

PubMed Central

Schatz, Michael C.

2015-01-01

The last 20 years have been a remarkable era for biology and medicine. One of the most significant achievements has been the sequencing of the first human genomes, which has laid the foundation for profound insights into human genetics, the intricacies of regulation and development, and the forces of evolution. Incredibly, as we look into the future over the next 20 years, we see the very real potential for sequencing more than 1 billion genomes, bringing even deeper insight into human genetics as well as the genetics of millions of other species on the planet. Realizing this great potential for medicine and biology, though, will only be achieved through the integration and development of highly scalable computational and quantitative approaches that can keep pace with the rapid improvements to biotechnology. In this perspective, I aim to chart out these future technologies, anticipate the major themes of research, and call out the challenges ahead. One of the largest shifts will be in the training used to prepare the class of 2035 for their highly interdisciplinary world. PMID:26430150

Stem cell technology for tendon regeneration: current status, challenges, and future research directions

PubMed Central

Lui, Pauline Po Yee

2015-01-01

Tendon injuries are a common cause of physical disability. They present a clinical challenge to orthopedic surgeons because injured tendons respond poorly to current treatments without tissue regeneration and the time required for rehabilitation is long. New treatment options are required. Stem cell-based therapies offer great potential to promote tendon regeneration due to their high proliferative, synthetic, and immunomodulatory activities as well as their potential to differentiate to the target cell types and undergo genetic modification. In this review, I first recapped the challenges of tendon repair by reviewing the anatomy of tendon. Next, I discussed the advantages and limitations of using different types of stem cells compared to terminally differentiated cells for tendon tissue engineering. The safety and efficacy of application of stem cells and their modified counterparts for tendon tissue engineering were then summarized after a systematic literature search in PubMed. The challenges and future research directions to enhance, optimize, and standardize stem cell-based therapies for augmenting tendon repair were then discussed. PMID:26715856

Impacts of climate variability and future climate change on harmful algal blooms and human health

PubMed Central

Moore, Stephanie K; Trainer, Vera L; Mantua, Nathan J; Parker, Micaela S; Laws, Edward A; Backer, Lorraine C; Fleming, Lora E

2008-01-01

Anthropogenically-derived increases in atmospheric greenhouse gas concentrations have been implicated in recent climate change, and are projected to substantially impact the climate on a global scale in the future. For marine and freshwater systems, increasing concentrations of greenhouse gases are expected to increase surface temperatures, lower pH, and cause changes to vertical mixing, upwelling, precipitation, and evaporation patterns. The potential consequences of these changes for harmful algal blooms (HABs) have received relatively little attention and are not well understood. Given the apparent increase in HABs around the world and the potential for greater problems as a result of climate change and ocean acidification, substantial research is needed to evaluate the direct and indirect associations between HABs, climate change, ocean acidification, and human health. This research will require a multidisciplinary approach utilizing expertise in climatology, oceanography, biology, epidemiology, and other disciplines. We review the interactions between selected patterns of large-scale climate variability and climate change, oceanic conditions, and harmful algae. PMID:19025675

Gravitational biology on the space station

NASA Technical Reports Server (NTRS)

Keefe, J. R.; Krikorian, A. D.

1983-01-01

The current status of gravitational biology is summarized, future areas of required basic research in earth-based and spaceflight projects are presented, and potential applications of gravitational biology on a space station are demonstrated. Topics covered include vertebrate reproduction, prenatal/postnatal development, a review of plant space experiments, the facilities needed for growing plants, gravimorphogenesis, thigmomorphogenesis, centrifuges, maintaining a vivarium, tissue culture, and artificial human organ generation. It is proposed that space stations carrying out these types of long-term research be called the National Space Research Facility.

Outcomes in mothers with rheumatic diseases and their offspring workshop

PubMed Central

Neville, Autumn; Bernatsky, Sasha; Kuriya, Bindee; Bujold, Emmanuel; Chakravarty, Eliza; Platt, Robert W; Bérard, Anick; Vinet, Évelyne

2017-01-01

This conference report describes six presentations that were given during a Canadian Institutes for Health Research-funded workshop. The goal of the workshop was to discuss key knowledge gaps in the study of outcomes in mothers with rheumatic diseases and their offspring. Presentations focused on epidemiological and methodological issues associated with the reproductive and perinatal health of women with rheumatic diseases. Discussions of relevant recent research allowed for discovery of potential data sources that could facilitate interdisciplinary research and created the opportunity for future collaborations.

Infusing Science into Politics and Policy: The Importance of Legislators as an Audience in Mental Health Policy Dissemination Research.

PubMed

Purtle, Jonathan; Brownson, Ross C; Proctor, Enola K

2017-03-01

Legislators (i.e., elected Senators and House Representatives at the federal- and state-level) are a critically important dissemination audience because they shape the architecture of the US mental health system through budgetary and regulatory decisions. In this Point of View, we argue that legislators are a neglected audience in mental health dissemination research. We synthesize relevant research, discuss its potential implications for dissemination efforts, identify challenges, and outline areas for future study.

INEL Geothermal Environmental Program. 1979 annual report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Thurow, T.L.; Sullivan, J.F.

1980-04-01

The Raft River Geothermal Environmental Program is designed to assess beneficial and detrimental impacts to the ecosystem resulting from the development of moderate temperature geothermal resources in the valley. The results of this research contribute to developing an understanding of Raft River Valley ecology and provide a basis for making management decisions to reduce potential long-term detrimental impacts on the environment. The environmental monitoring and research efforts conducted during the past six years of geothermal development and planned future research are summarized.

Flight dynamics research for highly agile aircraft

NASA Technical Reports Server (NTRS)

Nguyen, Luat T.

1989-01-01

This paper highlights recent results of research conducted at the NASA Langley Research Center as part of a broad flight dynamics program aimed at developing technology that will enable future combat aircraft to achieve greatly enhanced agility capability at subsonic combat conditions. Studies of advanced control concepts encompassing both propulsive and aerodynamic approaches are reviewed. Dynamic stall phenomena and their potential impact on maneuvering performance and stability are summarized. Finally, issues of mathematical modeling of complex aerodynamics occurring during rapid, large amplitude maneuvers are discussed.

Behavioral Health and Disasters: Looking to the Future

PubMed Central

Palinkas, Lawrence A.

2014-01-01

Along with other manmade and natural disasters, oil spills produce profound and long-term impacts on the behavioral health of their survivors. While previous and ongoing research has focused on producing evidence of the breadth and depth of these impacts, future efforts must begin to translate this evidence into developing and implementing policies, programs and practices that effectively contribute to their prevention and mitigation. Drawing upon a conceptual framework of the behavioral health impacts of oil spills developed from data collected in the aftermath of the Exxon Valdez oil spill in 1989, this paper examines potential interventions designed to prevent or mitigate biopsychosocial, interpersonal and intrapersonal impacts on behavioral health. Future efforts to translate behavioral health research into effective practice will require the formation and maintenance of academic-community partnerships for the purpose of building resilience to these impacts and providing targeted services to those most vulnerable to their long-term consequences. PMID:24443145

Establishing lunar resource viability

NASA Astrophysics Data System (ADS)

Carpenter, J.; Fisackerly, R.; Houdou, B.

2016-11-01

Recent research has highlighted the potential of lunar resources as an important element of space exploration but their viability has not been demonstrated. Establishing whether or not they can be considered in future plans is a multidisciplinary effort, requiring scientific expertise and delivering scientific results. To this end various space agencies and private entities are looking to lunar resources, extracted and processed in situ, as a potentially game changing element in future space architectures, with the potential to increase scale and reduce cost. However, before any decisions can be made on the inclusion of resources in exploration roadmaps or future scenarios some big questions need to be answered about the viability of different resource deposits and the processes for extraction and utilisation. The missions and measurements that will be required to answer these questions, and which are being prepared by agencies and others, can only be performed through the engagement and support of the science community. In answering questions about resources, data and knowledge will be generated that is of fundamental scientific importance. In supporting resource prospecting missions the science community will de facto generate new scientific knowledge. Science enables exploration and exploration enables science.

Immunotherapy in hematologic malignancies: past, present, and future.

PubMed

Im, Annie; Pavletic, Steven Z

2017-04-24

The field of immunotherapy in cancer treatments has been accelerating over recent years and has entered the forefront as a leading area of ongoing research and promising therapies that have changed the treatment landscape for a variety of solid malignancies. Prior to its designation as the Science Breakthrough of the Year in 2013, cancer immunotherapy was active in the treatment of hematologic malignancies. This review provides a broad overview of the past, present, and potential future of immunotherapy in hematologic malignancies.

Component research for future propulsion systems

NASA Technical Reports Server (NTRS)

Walker, C. L.; Weden, G. J.; Zuk, J.

1981-01-01

Factors affecting the helicopter market are reviewed. The trade-offs involving acquisition cost, mission reliability, and life cycle cost are reviewed, including civil and military aspects. The potential for advanced vehicle configurations with substantial improvements in energy efficiency, operating economics, and characteristics to satisfy the demands of the future market are identified. Advanced propulsion systems required to support these vehicle configurations are discussed, as well as the component technology for the engine systems. Considerations for selection of components in areas of economics and efficiency are presented.

Biomimicry in textiles: past, present and potential. An overview

PubMed Central

Eadie, Leslie; Ghosh, Tushar K.

2011-01-01

The natural world around us provides excellent examples of functional systems built with a handful of materials. Throughout the millennia, nature has evolved to adapt and develop highly sophisticated methods to solve problems. There are numerous examples of functional surfaces, fibrous structures, structural colours, self-healing, thermal insulation, etc., which offer important lessons for the textile products of the future. This paper provides a general overview of the potential of bioinspired textile structures by highlighting a few specific examples of pertinent, inherently sustainable biological systems. Biomimetic research is a rapidly growing field and its true potential in the development of new and sustainable textiles can only be realized through interdisciplinary research rooted in a holistic understanding of nature. PMID:21325320

Biomimicry in textiles: past, present and potential. An overview.

PubMed

Eadie, Leslie; Ghosh, Tushar K

2011-06-06

The natural world around us provides excellent examples of functional systems built with a handful of materials. Throughout the millennia, nature has evolved to adapt and develop highly sophisticated methods to solve problems. There are numerous examples of functional surfaces, fibrous structures, structural colours, self-healing, thermal insulation, etc., which offer important lessons for the textile products of the future. This paper provides a general overview of the potential of bioinspired textile structures by highlighting a few specific examples of pertinent, inherently sustainable biological systems. Biomimetic research is a rapidly growing field and its true potential in the development of new and sustainable textiles can only be realized through interdisciplinary research rooted in a holistic understanding of nature. © 2011 The Royal Society

Modelling Bambara Groundnut Yield in Southern Africa: Towards a Climate-Resilient Future

NASA Technical Reports Server (NTRS)

Karunaratne, A. S.; Walker, S.; Ruane, A. C.

2015-01-01

Current agriculture depends on a few major species grown as monocultures that are supported by global research underpinning current productivity. However, many hundreds of alternative crops have the potential to meet real world challenges by sustaining humanity, diversifying agricultural systems for food and nutritional security, and especially responding to climate change through their resilience to certain climate conditions. Bambara groundnut (Vigna subterranea (L.) Verdc.), an underutilised African legume, is an exemplar crop for climate resilience. Predicted yield performances of Bambara groundnut by AquaCrop (a crop-water productivity model) were evaluated for baseline (1980-2009) and mid-century climates (2040-2069) under 20 downscaled Global Climate Models (CMIP5-RCP8.5), as well as for climate sensitivities (AgMIPC3MP) across 3 locations in Southern Africa (Botswana, South Africa, Namibia). Different land - races of Bambara groundnut originating from various semi-arid African locations showed diverse yield performances with diverse sensitivities to climate. S19 originating from hot-dry conditions in Namibia has greater future yield potential compared to the Swaziland landrace Uniswa Red-UN across study sites. South Africa has the lowest yield under the current climate, indicating positive future yield trends. Namibia reported the highest baseline yield at optimum current temperatures, indicating less yield potential in future climates. Bambara groundnut shows positive yield potential at temperatures of up to 31degC, with further warming pushing yields down. Thus, many regions in Southern Africa can utilize Bambara groundnut successfully in the coming decades. This modelling exercise supports decisions on genotypic suitability for present and future climates at specific locations.

In the Blink of an Eye: Investigating the Role of Awareness in Fear Responding by Measuring the Latency of Startle Potentiation

PubMed Central

Åsli, Ole; Flaten, Magne A.

2012-01-01

The latency of startle reflex potentiation may shed light on the aware and unaware processes underlying associative learning, especially associative fear learning. We review research suggesting that single-cue delay classical conditioning is independent of awareness of the contingency between the conditioned stimulus (CS) and the unconditioned stimulus (US). Moreover, we discuss research that argues that conditioning independent of awareness has not been proven. Subsequently, three studies from our lab are presented that have investigated the role of awareness in classical conditioning, by measuring the minimum latency from CS onset to observed changes in reflexive behavior. In sum, research using this method shows that startle is potentiated 30 to 100 ms after CS onset following delay conditioning. Following trace fear conditioning, startle is potentiated 1500 ms after CS presentation. These results indicate that the process underlying delay conditioned responding is independent of awareness, and that trace fear conditioned responding is dependent on awareness. Finally, this method of investigating the role of awareness is discussed and future research possibilities are proposed. PMID:24962686

Engineering chimeras for Noah's ark.

PubMed

Dixon, B

1984-04-01

Chimeras, or animals containing the tissues of two or more distinct genetic types, have been successfully created from goat-sheep combinations by research teams at the ARC Institute of Animal Physiology in Cambridge, England, and the Justus-Liebig-Universitat in Giessen, West Germany. Dixon describes the methods used in this research and goes on to discuss the future potential for creating true hybrids capable of reproducing themselves, perhaps even involving human-animal combinations.

Aerial Flyover of New Research Facilities

ScienceCinema

None

2018-02-14

The Idaho National Laboratory is focused on continued development of its primary campus areas, including our Idaho Falls campus, to enable the INL to meet DOE expectations as the nations lead nuclear energy laboratory. This video identifies some of the existing Idaho Falls campus facilities and highlights planned and potential future development to support campus growth. You can learn more about INL's energy research projects at http://www.facebook.com/idahonationallaboratory.

The potential of induced pluripotent stem cells as a tool to study skeletal dysplasias and cartilage-related pathologic conditions.

PubMed

Liu, H; Yang, L; Yu, F F; Wang, S; Wu, C; Qu, C; Lammi, M J; Guo, X

2017-05-01

The development of induced pluripotent stem cells (iPSCs) technology has opened up new horizons for development of new research tools especially for skeletal dysplasias, which often lack human disease models. Regenerative medicine and tissue engineering could be the next areas to benefit from refinement of iPSC methods to repair focal cartilage defects, while applications for osteoarthritis (OA) and drug screening have evolved rather slowly. Although the advances in iPSC research of skeletal dysplasias and repair of focal cartilage lesions are not directly relevant to OA, they can be considered to pave the way to future prospects and solutions to OA research, too. The same problems which face the present cell-based treatments of cartilage injuries concern also the iPSC-based ones. However, established iPSC lines, which have no genomic aberrations and which efficiently differentiate into extracellular matrix secreting chondrocytes, could be an invaluable cell source for cell transplantations in the future. The safety issues concerning the recipient risks of teratoma formation and immune response still have to be solved before the potential use of iPSCs in cartilage repair of focal cartilage defects and OA. Copyright © 2016 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.

Digital Technologies in the Treatment of Anxiety: Recent Innovations and Future Directions.

PubMed

Firth, Joseph; Torous, John; Carney, Rebekah; Newby, Jill; Cosco, Theodore D; Christensen, Helen; Sarris, Jerome

2018-05-19

This review aims to provide a comprehensive overview of the efficacy, limitations, and future of e-health treatments for anxiety. Within this, we provide detail on "first-generation" e-health approaches, such as computerized therapies. Additionally, we assess the emergence and early efficacy of newer methods of treatment delivery, including smartphone apps and virtual reality interventions, discussing the potential and pitfalls for each. There is now substantial clinical research demonstrating the efficacy of internet-delivered cognitive behavioral therapy in the treatment of anxiety. However, the ability of these interventions for engaging patients in "real-world" settings is unclear. Recently, smartphone apps for anxiety have presented a more popular and ubiquitous method of intervention delivery, although the evidence base supporting these newer approaches drastically falls behind the extensive marketing and commercialization efforts currently driving their development. Meanwhile, the increasing availability of novel technologies, such as "virtual reality" (VR), introduces further potential of e-health treatments for generalized anxiety and anxiety-related disorders such as phobias and obsessive compulsive disorder, while also creating additional challenges for research. Although still in its infancy, e-health research is already presenting several promising avenues for delivering effective and scalable treatments for anxiety. Nonetheless, several important steps must be taken in order for academic research to keep pace with continued technological advances.

Found in translation: Integrating laboratory and clinical oncology research

PubMed Central

Wagner, H

2008-01-01

Translational research in medicine aims to inform the clinic and the laboratory with the results of each other’s work, and to bring promising and validated new therapies into clinical application. While laudable in intent, this is complicated in practice and the current state of translational research in cancer shows both striking success stories and examples of the numerous potential obstacles as well as opportunities for delays and errors in translation. This paper reviews the premises, promises, and problems of translational research with a focus on radiation oncology and suggests opportunities for improvements in future research design. PMID:21611010

Charting the landscape of priority problems in psychiatry, part 1: classification and diagnosis.

PubMed

Stephan, Klaas E; Bach, Dominik R; Fletcher, Paul C; Flint, Jonathan; Frank, Michael J; Friston, Karl J; Heinz, Andreas; Huys, Quentin J M; Owen, Michael J; Binder, Elisabeth B; Dayan, Peter; Johnstone, Eve C; Meyer-Lindenberg, Andreas; Montague, P Read; Schnyder, Ulrich; Wang, Xiao-Jing; Breakspear, Michael

2016-01-01

Contemporary psychiatry faces major challenges. Its syndrome-based disease classification is not based on mechanisms and does not guide treatment, which largely depends on trial and error. The development of therapies is hindered by ignorance of potential beneficiary patient subgroups. Neuroscientific and genetics research have yet to affect disease definitions or contribute to clinical decision making. In this challenging setting, what should psychiatric research focus on? In two companion papers, we present a list of problems nominated by clinicians and researchers from different disciplines as candidates for future scientific investigation of mental disorders. These problems are loosely grouped into challenges concerning nosology and diagnosis (this Personal View) and problems related to pathogenesis and aetiology (in the companion Personal View). Motivated by successful examples in other disciplines, particularly the list of Hilbert's problems in mathematics, this subjective and eclectic list of priority problems is intended for psychiatric researchers, helping to re-focus existing research and providing perspectives for future psychiatric science. Copyright © 2016 Elsevier Ltd. All rights reserved.

[Evaluation of the first training on clinical research methodology in Chile].

PubMed

Espinoza, Manuel; Cabieses, Báltica; Pedreros, César; Zitko, Pedro

2011-03-01

This paper describes the evaluation of the first training on clinical research methodology in Chile (EMIC-Chile) 12 months after its completion. An online survey was conducted for students and the Delphi method was used for the teaching team. Among the students, the majority reported that the program had contributed to their professional development and that they had shared some of the knowledge acquired with colleagues in their workplace. Forty-one percent submitted a project to obtain research funding through a competitive grants process once they had completed the course. Among the teachers, the areas of greatest interest were the communication strategy, teaching methods, the characteristics of the teaching team, and potential strategies for making the EMIC-Chile permanent in the future. This experience could contribute to future research training initiatives for health professionals. Recognized challenges are the involvement of nonmedical professions in clinical research, the complexities associated with the distance learning methodology, and the continued presence of initiatives of this importance at the national and regional level.

Future Research and Policy Directions in Physician Reimbursement

PubMed Central

McMenamin, Peter

1981-01-01

Payments to physicians absorb the second largest share of the health care dollar in the United States. In 1979, the share was 19 percent of the total, or $40.6 billion (Gibson, 1980). The Health Care Financing Administration (HCFA) alone spent $8.6 billion for physician services, representing approximately 16 percent of all public funds disbursed under HCFA programs. This paper presents an overview of various issues concerning physician reimbursement. Several major areas have been identified (access, cost, quality, and improving or refining the Office of Research, Demonstrations, and Statistics' [ORDS] research techniques for analyzing topics concerning physician reimbursement). Each area is introduced with a brief discussion of some of the problems associated with the physician reimbursement systems relating to that area. Selected results are then presented from the previous research in each area, along with descriptions of continuing studies currently underway. Each section concludes with a discussion of potential future directions for new research or data development. PMID:10309465

Research on Social Networking Sites and Social Support from 2004 to 2015: A Narrative Review and Directions for Future Research.

PubMed

Meng, Jingbo; Martinez, Lourdes; Holmstrom, Amanda; Chung, Minwoong; Cox, Jeff

2017-01-01

The article presents a narrative review of scholarship on social support through social networking sites (SNSs) published from 2004 to 2015. By searching keywords related to social support and SNSs in major databases for social sciences, we identified and content analyzed directly relevant articles (N = 88). The article summarizes the prevalence of theory usage; the function of theory usage (e.g., testing a theory, developing a theory); major theories referenced; and methodologies, including research designs, measurement, and the roles of social support and SNS examined in this literature. It also reports four themes identified across the studies, indicating the trends in the current research. Based on the review, the article presents a discussion about study sites, conceptualization of social support, theoretical coherence, the role of social networks, and the dynamic relationships between SNS use and social support, which points out potential avenues for shaping a future research agenda.

"I don't want to be Henrietta Lacks": diverse patient perspectives on donating biospecimens for precision medicine research.

PubMed

Lee, Sandra S-J; Cho, Mildred K; Kraft, Stephanie A; Varsava, Nina; Gillespie, Katie; Ormond, Kelly E; Wilfond, Benjamin S; Magnus, David

2018-06-11

To determine whether patients distinguish between biospecimens and electronic health records (EHRs) when considering research participation to inform research protections. We conducted 20 focus groups with individuals who identified as African American, Hispanic, Chinese, South Asian, and non-Hispanic white on the collection of biospecimens and EHR data for research. Our study found that many participants did not distinguish between biospecimens and EHR data. However, some participants identified specific concerns about biospecimens. These included the need for special care and respect for biospecimens due to enduring connections between the body and identity; the potential for unacceptable future research, specifically the prospect of human cloning; heightened privacy risks; and the potential for unjust corporate profiteering. Among those who distinguished biospecimens from EHR data, many supported separate consent processes and would limit their own participation to EHR data. Considering that the potential misuse of EHR data is as great as, if not greater than, for biospecimens, more research is needed to understand how attitudes differ between biospecimens and EHR data across diverse populations. Such research should explore mechanisms beyond consent that can address diverse values, perspectives, and misconceptions about sources of patient information to build trust in research relationships.

An overview of computer-based natural language processing

NASA Technical Reports Server (NTRS)

Gevarter, W. B.

1983-01-01

Computer based Natural Language Processing (NLP) is the key to enabling humans and their computer based creations to interact with machines in natural language (like English, Japanese, German, etc., in contrast to formal computer languages). The doors that such an achievement can open have made this a major research area in Artificial Intelligence and Computational Linguistics. Commercial natural language interfaces to computers have recently entered the market and future looks bright for other applications as well. This report reviews the basic approaches to such systems, the techniques utilized, applications, the state of the art of the technology, issues and research requirements, the major participants and finally, future trends and expectations. It is anticipated that this report will prove useful to engineering and research managers, potential users, and others who will be affected by this field as it unfolds.

An overview of NASA research on positive displacement general-aviation engines

NASA Technical Reports Server (NTRS)

Kempke, E. E., Jr.

1980-01-01

The research and technology program related to improved and advanced general aviation engines is described. Current research is directed at the near-term improvement of conventional air-cooled spark-ignition piston engines and at future alternative engine systems based on all-new spark-ignition piston engines, lightweight diesels, and rotary combustion engines that show potential for meeting program goals in the midterm and long-term future. The conventional piston engine activities involve efforts on applying existing technology to improve fuel economy, investigation of key processes to permit leaner operation and reduce drag, and the development of cost effective technology to permit flight at high-altitudes where fuel economy and safety are improved. The advanced engine concepts activities include engine conceptual design studies and enabling technology efforts on the critical or key technology items.

Geographical thinking in nursing inquiry, part two: performance, possibility, and non-representational theory.

PubMed

Andrews, Gavin J

2017-04-01

Part one in this two paper series reviewed the nature of geographical thinking in nursing research thus far. The current paper builds on it by looking forwards and providing a particular vision for future research. It argues that it is time to once again look to the parent discipline of human geography for inspiration, specifically to its turn towards non-representational theory, involving an emphasis on life that onflows prior to meaning, significance, and full cognition; on life's 'taking-place'. The paper introduces this way of viewing and animating the world. Some potential connections to nursing research and practice are suggested, as are some specific avenues for future inquiry. Explained is how, through non-representational theory, nursing might be re-imagined as something that reveals space-time. © 2016 John Wiley & Sons Ltd.

The Effect of Advertising on Children and Adolescents.

PubMed

Lapierre, Matthew A; Fleming-Milici, Frances; Rozendaal, Esther; McAlister, Anna R; Castonguay, Jessica

2017-11-01

In ∼100 years, marketing to children went from a severely frowned upon practice to an integral part of growing up as companies came to realize that investing in marketing to children and adolescents provides excellent immediate and future dividends. Each year, enormous sums of money are spent to reach this valuable audience because children and adolescents spend billions on their own purchases, influence family decisions about what to buy, and promise a potential lifetime of brand loyalty. The channels to reach youth have grown, and marketers are increasingly using them, often blurring the distinction between entertainment and advertising. Because advertising to children and adolescents has become ubiquitous, researchers who study its influence raise significant concerns about the practice, especially as it relates to dietary behavior, family conflict, marketer tactics, and children's potential vulnerability as an audience. In this review by the Workgroup on Marketing and Advertising, we highlight the state of the research in this area and suggest that more research needs to be conducted on understanding the following: the effects of advertising exposure, how psychological development affects children's responses to marketing, the problems associated with advertising in newer media, and how researchers, parents, and practitioners might be able to mitigate the most deleterious advertising effects. We then present avenues of future research along with recommendations for key stakeholders. Copyright © 2017 by the American Academy of Pediatrics.

'A good fit?' Bringing the sociology of footwear to the clinical encounter in podiatry services: a narrative review.

PubMed

Nicholls, Emily; Robinson, Victoria; Farndon, Lisa; Vernon, Wesley

2018-01-01

This narrative review explores the ways in which drawing on theories and methods used in sociological work on footwear and identity can contribute to healthcare research with podiatrists and their patients, highlighting recent research in this field, implications for practice and potential areas for future development.Traditionally, research within Podiatry Services has tended to adopt a quantitative, positivist focus, developing separately from a growing body of sociological work exploring the importance of shoes in constructing identity and self-image. Bringing qualitative research drawing on sociological theory and methods to the clinical encounter has real potential to increase our understanding of patient values, motivations and - crucially - any barriers to adopting 'healthier' footwear that they may encounter. Such work can help practitioners to understand why patients may resist making changes to their footwear practices, and help us to devise new ways for practitioners to explore and ultimately break down individual barriers to change (including their own preconceptions as practitioners). This, in turn, may lead to long-term, sustainable changes to footwear practices and improvements in foot health for those with complex health conditions and the wider population. A recognition of the complex links between shoes and identity is opening up space for discussion of patient resistance to footwear changes, and paving the way for future research in this field beyond the temporary 'moment' of the clinical encounter.

Preparation for future learning: a missing competency in health professions education?

PubMed

Mylopoulos, Maria; Brydges, Ryan; Woods, Nicole N; Manzone, Julian; Schwartz, Daniel L

2016-01-01

Evidence suggests that clinicians may not be learning effectively from all facets of their practice, potentially because their training has not fully prepared them to do so. To address this gap, we argue that there is a need to identify systems of instruction and assessment that enhance clinicians' 'preparation for future learning'. Preparation for future learning (PFL) is understood to be the capacity to learn new information, to use resources effectively and innovatively, and to invent new strategies for learning and problem solving in practice. Education researchers have developed study designs that use dynamic assessments to measure what trainees have acquired in the past, as well as what they are able to learn in the present. More recently, researchers have also started to emphasise and measure whether and how trainees take action to gain the information they need to learn. Knowing that there are study designs and emerging metrics for assessing PFL, the next question is how to design instruction that helps trainees develop PFL capacities. Although research evidence is still accumulating, the current evidence base suggests training that encourages 'productive failure' through guided discovery learning (i.e. where trainees solve problems and perform tasks without direct instruction, though often with some form of feedback) creates challenging conditions that enhance learning and equip trainees with PFL-related behaviours. Preparation for future learning and the associated capacity of being adaptive as one learns in and from training and clinical practice have been missed in most contemporary training and assessment systems. We propose a research agenda that (i) explores how real-world adaptive expert activity unfolds in the health care workplace to inform the design of instruction for developing PFL, (ii) identifies measures of behaviours that relate to PFL, and (iii) addresses potential sociocultural barriers that limit clinicians' opportunities to learn from their daily practice. © 2015 John Wiley & Sons Ltd.

Patients living with disabilities: The need for high-quality primary care.

PubMed

Lofters, Aisha; Guilcher, Sara; Maulkhan, Niraj; Milligan, James; Lee, Joseph

2016-08-01

To compare the potential risk factors for lower-quality primary care, the potential markers of unmet needs in primary care, and the willingness to participate in future research among primary care patients with versus without physical disabilities. A waiting room survey using a convenience sample. A family health team (FHT) in Kitchener-Waterloo, Ont, with a designated Mobility Clinic. A total of 40 patients seen at the FHT Mobility Clinic and 80 patients from the general patient population of the same FHT. Socioeconomic status and social capital, number of self-reported emergency department visits and hospitalizations in the preceding year, and willingness of the patients in the 2 groups to participate in future research studies. Patients from the Mobility Clinic were more than twice as likely to be receiving benefits or social assistance (75.0% vs 32.1%, P < .001), were twice as likely to report an annual household income of less than $40000 (58.6% vs 29.2%, P = .006), and were more likely to report their health status to be fair or poor (42.5% vs 16.2%, P = .002). Half of Mobility Clinic patients had visited the emergency department at least once in the preceding year, compared with 29.7% in the general patient population (P = .027). When asked if they would be willing to provide their health card number in the future so that it could be linked to health care data for research, 82.5% of Mobility Clinic patients agreed versus 55.0% of those in the general patient population (P = .004). In this study, patients with disabilities were at a social disadvantage compared with their peers without disabilities and were more likely to use the emergency department, suggesting that they had unmet health needs. Future research should continue to explore this patient population and to investigate if an interprofessional primary health care team approach focused on patients with disabilities can help to increase quality of care. Copyright© the College of Family Physicians of Canada.

Selection bias in rheumatic disease research.

PubMed

Choi, Hyon K; Nguyen, Uyen-Sa; Niu, Jingbo; Danaei, Goodarz; Zhang, Yuqing

2014-07-01

The identification of modifiable risk factors for the development of rheumatic conditions and their sequelae is crucial for reducing the substantial worldwide burden of these diseases. However, the validity of such research can be threatened by sources of bias, including confounding, measurement and selection biases. In this Review, we discuss potentially major issues of selection bias--a type of bias frequently overshadowed by other bias and feasibility issues, despite being equally or more problematic--in key areas of rheumatic disease research. We present index event bias (a type of selection bias) as one of the potentially unifying reasons behind some unexpected findings, such as the 'risk factor paradox'--a phenomenon exemplified by the discrepant effects of certain risk factors on the development versus the progression of osteoarthritis (OA) or rheumatoid arthritis (RA). We also discuss potential selection biases owing to differential loss to follow-up in RA and OA research, as well as those due to the depletion of susceptibles (prevalent user bias) and immortal time bias. The lesson remains that selection bias can be ubiquitous and, therefore, has the potential to lead the field astray. Thus, we conclude with suggestions to help investigators avoid such issues and limit the impact on future rheumatology research.

Selection bias in rheumatic disease research

PubMed Central

Choi, Hyon K.; Nguyen, Uyen-Sa; Niu, Jingbo; Danaei, Goodarz; Zhang, Yuqing

2014-01-01

The identification of modifiable risk factors for the development of rheumatic conditions and their sequelae is crucial for reducing the substantial worldwide burden of these diseases. However, the validity of such research can be threatened by sources of bias, including confounding, measurement and selection biases. In this Review, we discuss potentially major issues of selection bias—a type of bias frequently overshadowed by other bias and feasibility issues, despite being equally or more problematic—in key areas of rheumatic disease research. We present index event bias (a type of selection bias) as one of the potentially unifying reasons behind some unexpected findings, such as the ‘risk factor paradox’—a phenomenon exemplified by the discrepant effects of certain risk factors on the development versus the progression of osteoarthritis (OA) or rheumatoid arthritis (RA). We also discuss potential selection biases owing to differential loss to follow-up in RA and OA research, as well as those due to the depletion of susceptibles (prevalent user bias) and immortal time bias. The lesson remains that selection bias can be ubiquitous and, therefore, has the potential to lead the field astray. Thus, we conclude with suggestions to help investigators avoid such issues and limit the impact on future rheumatology research. PMID:24686510

POLLUTION FROM THE COMBINED ACTIVITIES, ACTIONS, AND BEHAVIORS OF THE PUBLIC: PHARMACEUTICALS AND PERSONAL CARE PRODUCTS

EPA Science Inventory

ORD's four-fold objectives in its efforts have been to: (i) Identify potential (future) environmental concerns (anticipatory research and identification of emerging issues, especially to identify pivotal sources of uncertainty that might affect risk estimates), (ii) Be proactive ...

Chemistry of Carbon Nanotubes for Everyone

ERIC Educational Resources Information Center

Basu-Dutt, Sharmistha; Minus, Marilyn L.; Jain, Rahul; Nepal, Dhriti; Kumar, Satish

2012-01-01

Carbon nanotubes (CNTs) have the extraordinary potential to change our lives by improving existing products and enabling new ones. Current and future research and industrial workforce professionals are very likely to encounter some aspects of nanotechnology including CNT science and technology in their education or profession. The simple structure…

MINE WASTE TECHNOLOGY PROGRAM:HISTORICAL PERSPECTIVES. CURRENT HIGHLIGHTS, FUTURE OPPORTUNITIES

EPA Science Inventory

For the past 13 years, the Mine Waste Technology Program has been technically driven by the National Risk Management Research Lab. A portion of the MWTP funding has been used to perform field demonstrations of innovative technologies with the potential to address mine waste issue...

BIODIESEL EXHAUST: THE NEED FOR HUMAN HEALTH EFFECTS RESEARCH

EPA Science Inventory

Biodiesel is a diesel fuel alternative that has shown potential of becoming a commercially accepted part of the United States energy infrastructure. In November of 2004, the signing of the Jobs Creation Bill HR4520 marked an important turning point for the future production of bi...

Glysphosate-resistant Palmer amaranth (Amaranthus palmeri) morphology,growth, and seed production in Georgia

USDA-ARS?s Scientific Manuscript database

Herbicide resistant Palmer amaranth has become the most economically detrimental weed of cotton in the Southeast US. With the continual marginalization of potential herbicide tools, research has expanded to include alternative means of affecting future Palmer amaranth populations by altering safe s...

Glyphosate-resistant Palmer amaranth (Amaranthus palmeri) morphology, growth, and seed production in Georgia

USDA-ARS?s Scientific Manuscript database

Herbicide resistant Palmer amaranth has become the most economically detrimental weed of cotton in the Southeast US. With the continual marginalization of potential herbicide tools, research has expanded to include alternative means of affecting future Palmer amaranth populations by altering safe s...

RU-486: Abortion Controversy in U.S. Clouds Future of Promising Drug.

ERIC Educational Resources Information Center

Baum, Rudy M.

1991-01-01

Reviewed is the debate over research and approval of the use of this drug in the United States. Potential benefits and side effects of the drug are discussed. The points of view of several government officials, scientists, and social activists are presented. (CW)

Impact of Biotechnology on Pharmacy Practice.

ERIC Educational Resources Information Center

Black, Curtis D.; And Others

1990-01-01

Discussed is the role of schools of pharmacy in (1) preparing future practitioners to assimilate and shape the impact of biotechnology; (2) establish graduate and research programs to enhance and apply products of biotechnology; and (3) identify manpower needs to fully realize potential advances caused by biotechnology. (DB)

Photovoltaics as a terrestrial energy source. Volume 1: An introduction

NASA Technical Reports Server (NTRS)

Smith, J. L.

1980-01-01

Photovoltaic (PV) systems were examined their potential for terrestrial application and future development. Photovoltaic technology, existing and potential photovoltaic applications, and the National Photovoltaics Program are reviewed. The competitive environment for this electrical source, affected by the presence or absence of utility supplied power is evaluated in term of systems prices. The roles of technological breakthroughs, directed research and technology development, learning curves, and commercial demonstrations in the National Program are discussed. The potential for photovoltaics to displace oil consumption is examined, as are the potential benefits of employing PV in either central-station or non-utility owned, small, distributed systems.

Eating disorders: Insights from imaging and behavioral approaches to treatment.

PubMed

Stice, Eric; Shaw, Heather

2017-11-01

Understanding factors that contribute to eating disorders, which affect 13% of females, is critical to developing effective prevention and treatment programs. In this paper, we summarize results from prospective studies that identified factors predicting onset and persistence of eating disorders and core symptom dimensions. Next, implications for intervention targets for prevention, and treatment interventions from the risk- and maintenance-factor findings are discussed. Third, given that evidence suggests eating disorders are highly heritable, implying biological risk and maintenance factors for eating disorders, we offer working hypotheses about biological factors that might contribute to eating disorders, based on extant risk factor findings, theory, and cross-sectional studies. Finally, potentially fruitful directions for future research are presented. We suggest that it would be useful for experimental therapeutics trials to evaluate the effects of reducing the risk factors on future onset of eating pathology and on reducing maintenance factors on the risk for persistence of eating pathology, and encourage researchers to utilize prospective high-risk studies so that knowledge regarding potential intervention targets for prevention and treatment interventions for eating disorders can be advanced. Using the most rigorous research designs should help improve the efficacy of prevention and treatment interventions for eating disorders.

Is ambiguity tolerance malleable? Experimental evidence with potential implications for future research

PubMed Central

Endres, Megan L.; Camp, Richaurd; Milner, Morgan

2015-01-01

We conducted two research studies to address the malleability of tolerance of ambiguity (TA) by manipulating situational ambiguity. Students participated in a semester-end assessment of their management skills (n = 306). In Study 1, students in low and moderate ambiguity conditions had significantly higher post-experiment TA, more positive change in self-efficacy, and marginally higher faculty ratings. In Study 2, a control group (n = 103) did not participate in the assessment and was established for comparison to the first study results. The Study 2 students reported TA significantly lower than Study 1 students in the low and moderate ambiguity conditions. The control group TA was not significantly different from that of the Study 1 high ambiguity condition. This further suggested TA’s situational malleability, as those who had controlled access to structured information appeared to have increased their TA over that observed in the other two groups. These results suggest that TA may be malleable. We review the relevant literature, offer hypotheses, report our analyses and findings, and then propose future research, and potential prescriptive applications in such areas as management development, assessment, and decision-making. PMID:26042059

The future of textile production in high wage countries

NASA Astrophysics Data System (ADS)

Kemper, M.; Gloy, Y.-S.; Gries, T.

2017-10-01

It is undisputed that smart production in the context of industry 4.0 offers significant potential for industrial production in Germany. Exploiting this potential provides an opportunity to meet the growing competitive pressure for textile production in high-wage Germany. The complete cross-linking of textile mills towards Textile Production 4.0 means substantial savings. However, currently there are still some challenges that have to be overcome on the long way to Textile Production 4.0. This paper initially reflects the particular challenges of textile production in high-wage Germany. Later, the vision of the future of smart textile production will be outlined. In addition, first pilot solutions and current research approaches which pave the way for Textile Production 4.0 are described.

Road to the future of systems biotechnology: CRISPR-Cas-mediated metabolic engineering for recombinant protein production.

PubMed

Roointan, Amir; Morowvat, Mohammad Hossein

The rising potential for CRISPR-Cas-mediated genome editing has revolutionized our strategies in basic and practical bioengineering research. It provides a predictable and precise method for genome modification in a robust and reproducible fashion. Emergence of systems biotechnology and synthetic biology approaches coupled with CRISPR-Cas technology could change the future of cell factories to possess some new features which have not been found naturally. We have discussed the possibility and versatile potentials of CRISPR-Cas technology for metabolic engineering of a recombinant host for heterologous protein production. We describe the mechanisms involved in this metabolic engineering approach and present the diverse features of its application in biotechnology and protein production.

Qualitative research in rehabilitation science: opportunities, challenges, and future directions.

PubMed

VanderKaay, Sandra; Moll, Sandra E; Gewurtz, Rebecca E; Jindal, Pranay; Loyola-Sanchez, Adalberto; Packham, Tara L; Lim, Chun Y

2018-03-01

Qualitative research has had a significant impact within rehabilitation science over time. During the past 20 years the number of qualitative studies published per year in Disability and Rehabilitation has markedly increased (from 1 to 54). In addition, during this period there have been significant changes in how qualitative research is conceptualized, conducted, and utilized to advance the field of rehabilitation. The purpose of this article is to reflect upon the progress of qualitative research within rehabilitation to date, to explicate current opportunities and challenges, and to suggest future directions to continue to strengthen the contribution of qualitative research in this field. Relevant literature searches were conducted in electronic data bases and reference lists. Pertinent literature was examined to identify current opportunities and challenges for qualitative research use in rehabilitation and to identify future directions. Six key areas of opportunity and challenge were identified: (a) paradigm shifts, (b) advancements in methodology, (c) emerging technology, (d) advances in quality evaluation, (e) increasing popularity of mixed methods approaches, and (f) evolving approaches to knowledge translation. Two important future directions for rehabilitation are posited: (1) advanced training in qualitative methods and (2) engaging qualitative communities of research. Qualitative research is well established in rehabilitation and has an important place in the continued growth of this field. Ongoing development of qualitative researchers and methods are essential. Implications for Rehabilitation Qualitative research has the potential to improve rehabilitation practice by addressing some of the most pervasive concerns in the field such as practitioner-client interaction, the subjective and lived experience of disability, and clinical reasoning and decision making. This will serve to better inform those providing rehabilitation services thereby benefiting patients that are utilizing these services. Changes over time in how qualitative research is conceptualized, conducted, and utilized to advance rehabilitation science have resulted in a number of unique opportunities and challenges in using qualitative research that must be considered within this field. Advances in methodology and increased expectations for evaluation must be considered to ensure quality and credibility of qualitative rehabilitation research within rehabilitation. Improved quality and credibility may increase likelihood of research dissemination and use by clinicians intervening within the rehabilitation process in order to improve clinical practice. In order to maximize opportunities and mitigate challenges there are two principal future directions for rehabilitation scientists to consider: (1) advancing training in qualitative methods to adequately prepare future rehabilitation scientists and (2) engaging qualitative communities of research.

Global-local methodologies and their application to nonlinear analysis

NASA Technical Reports Server (NTRS)

Noor, Ahmed K.

1989-01-01

An assessment is made of the potential of different global-local analysis strategies for predicting the nonlinear and postbuckling responses of structures. Two postbuckling problems of composite panels are used as benchmarks and the application of different global-local methodologies to these benchmarks is outlined. The key elements of each of the global-local strategies are discussed and future research areas needed to realize the full potential of global-local methodologies are identified.

Impact of the Health Insurance Portability and Accountability Act on participant recruitment and retention.

PubMed

Wipke-Tevis, Deidre D; Pickett, Melissa A

2008-02-01

Recruiting and retaining an adequate sample is critical to the success of any research project involving humans. Recent reports indicate that the Health Insurance Portability and Accountability Act (HIPAA) privacy rule has adversely affected research. Few resources are available to help researchers navigate the challenges to recruitment and retention after HIPAA privacy rule implementation. This article addresses obstacles to recruitment in prospective clinical research studies related to the HIPAA privacy rule, as well as HIPAA-compliant strategies to enhance recruitment and retention. Recruitment challenges discussed include evolving interpretations of the HIPAA regulations, inability to directly contact potential participants, complexity of HIPAA-required documents, increased costs of recruitment, and an expanding administrative burden. Among the strategies addressed are preparatory research reviews, using clinical collaborators and staff liaisons, prescreening potential participants, minimizing participant burden during the consent process, enhancing participant follow-up, facilitating recruitment for future studies, and streamlining compliance training for staff.

Molecular nutrition research: the modern way of performing nutritional science.

PubMed

Norheim, Frode; Gjelstad, Ingrid Merethe Fange; Hjorth, Marit; Vinknes, Kathrine J; Langleite, Torgrim M; Holen, Torgeir; Jensen, Jørgen; Dalen, Knut Tomas; Karlsen, Anette S; Kielland, Anders; Rustan, Arild C; Drevon, Christian A

2012-12-03

In spite of amazing progress in food supply and nutritional science, and a striking increase in life expectancy of approximately 2.5 months per year in many countries during the previous 150 years, modern nutritional research has a great potential of still contributing to improved health for future generations, granted that the revolutions in molecular and systems technologies are applied to nutritional questions. Descriptive and mechanistic studies using state of the art epidemiology, food intake registration, genomics with single nucleotide polymorphisms (SNPs) and epigenomics, transcriptomics, proteomics, metabolomics, advanced biostatistics, imaging, calorimetry, cell biology, challenge tests (meals, exercise, etc.), and integration of all data by systems biology, will provide insight on a much higher level than today in a field we may name molecular nutrition research. To take advantage of all the new technologies scientists should develop international collaboration and gather data in large open access databases like the suggested Nutritional Phenotype database (dbNP). This collaboration will promote standardization of procedures (SOP), and provide a possibility to use collected data in future research projects. The ultimate goals of future nutritional research are to understand the detailed mechanisms of action for how nutrients/foods interact with the body and thereby enhance health and treat diet-related diseases.

Identifying and prioritising systematic review topics with public health stakeholders: A protocol for a modified Delphi study in Switzerland to inform future research agendas.

PubMed

Hoekstra, Dyon; Mütsch, Margot; Kien, Christina; Gerhardus, Ansgar; Lhachimi, Stefan K

2017-08-04

The Cochrane Collaboration aims to produce relevant and top priority evidence that responds to existing evidence gaps. Hence, research priority setting (RPS) is important to identify which potential research gaps are deemed most important. Moreover, RPS supports future health research to conform both health and health evidence needs. However, studies that are prioritising systematic review topics in public health are surprisingly rare. Therefore, to inform the research agenda of Cochrane Public Health Europe (CPHE), we introduce the protocol of a priority setting study on systematic review topics in several European countries, which is conceptualised as pilot. We will conduct a two-round modified Delphi study in Switzerland, incorporating an anonymous web-based questionnaire, to assess which topics should be prioritised for systematic reviews in public health. In the first Delphi round public health stakeholders will suggest relevant assessment criteria and potential priority topics. In the second Delphi round the participants indicate their (dis)agreement to the aggregated results of the first round and rate the potential review topics with the predetermined criteria on a four-point Likert scale. As we invite a wide variety of stakeholders we will compare the results between the different stakeholder groups. We have received ethical approval from the ethical board of the University of Bremen, Germany (principal investigation is conducted at the University of Bremen) and a certificate of non-objection from the Canton of Zurich, Switzerland (fieldwork will be conducted in Switzerland). The results of this study will be further disseminated through peer reviewed publication and will support systematic review author groups (i.a. CPHE) to improve the relevance of the groups´ future review work. Finally, the proposed priority setting study can be used as a framework by other systematic review groups when conducting a priority setting study in a different context. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

A methodology and decision support tool for informing state-level bioenergy policymaking: New Jersey biofuels as a case study

NASA Astrophysics Data System (ADS)

Brennan-Tonetta, Margaret

This dissertation seeks to provide key information and a decision support tool that states can use to support long-term goals of fossil fuel displacement and greenhouse gas reductions. The research yields three outcomes: (1) A methodology that allows for a comprehensive and consistent inventory and assessment of bioenergy feedstocks in terms of type, quantity, and energy potential. Development of a standardized methodology for consistent inventorying of biomass resources fosters research and business development of promising technologies that are compatible with the state's biomass resource base. (2) A unique interactive decision support tool that allows for systematic bioenergy analysis and evaluation of policy alternatives through the generation of biomass inventory and energy potential data for a wide variety of feedstocks and applicable technologies, using New Jersey as a case study. Development of a database that can assess the major components of a bioenergy system in one tool allows for easy evaluation of technology, feedstock and policy options. The methodology and decision support tool is applicable to other states and regions (with location specific modifications), thus contributing to the achievement of state and federal goals of renewable energy utilization. (3) Development of policy recommendations based on the results of the decision support tool that will help to guide New Jersey into a sustainable renewable energy future. The database developed in this research represents the first ever assessment of bioenergy potential for New Jersey. It can serve as a foundation for future research and modifications that could increase its power as a more robust policy analysis tool. As such, the current database is not able to perform analysis of tradeoffs across broad policy objectives such as economic development vs. CO2 emissions, or energy independence vs. source reduction of solid waste. Instead, it operates one level below that with comparisons of kWh or GGE generated by different feedstock/technology combinations at the state and county level. Modification of the model to incorporate factors that will enable the analysis of broader energy policy issues as those mentioned above, are recommended for future research efforts.

Current applications of nanotechnology in dentistry: a review.

PubMed

Bhavikatti, Shaeesta Khaleelahmed; Bhardwaj, Smiti; Prabhuji, M L V

2014-01-01

With the increasing demand for advances in diagnosis and treatment modalities, nanotechnology is being considered as a groundbreaking and viable research subject. This technology, which deals with matter in nanodimensions, has widened our views of poorly understood health issues and provided novel means of diagnosis and treatment. Researchers in the field of dentistry have explored the potential of nanoparticles in existing therapeutic modalities with moderate success. The key implementations in the field of dentistry include local drug delivery agents, restorative materials, bone graft materials, and implant surface modifications. This review provides detailed insights about current developments in the field of dentistry, and discusses potential future uses of nanotechnology.

Human Chorionic Gonadotropin: The Pregnancy Hormone and More.

PubMed

Theofanakis, Charalampos; Drakakis, Petros; Besharat, Alexandros; Loutradis, Dimitrios

2017-05-14

To thoroughly review the uses of human chorionic gonadotropin (hCG) related to the process of reproduction and also assess new, non-traditional theories. Review of the international literature and research studies. hCG and its receptor, LH/CGR, are expressed in numerous sites of the reproductive tract, both in gonadal and extra-goanadal tissues, promoting oocyte maturation, fertilization, implantation and early embryo development. Moreover, hCG seems to have a potential role as an anti-rejection agent in solid organ transplantation. Future research needs to focus extensively on the functions of hCG and its receptor LH/CGR, in an effort to reveal known, as well as unknown clinical potentials.

Peer volunteer perspectives following a complex social cognitive intervention: a qualitative investigation.

PubMed

McHugh, J E; Lee, O; Aspell, N; Connolly, L; Lawlor, B A; Brennan, S

2016-09-01

Peer volunteers can be key to delivering effective social cognitive interventions due to increased potential for social modeling. We consulted peer volunteers who had just taken part in an 8-week social and nutritional mealtime intervention with older adults living alone, to seek their evaluation of the intervention. Semi-structured focus groups were used with a total of 21 volunteers (17 female) and two facilitators. Thematic analysis was used to interrogate the data. Six themes (16 sub-themes) are discussed. Peer volunteers described the importance of the socializing aspect of the intervention, of pairing considerations and compatibility in peer interventions, of considering the needs of the participant, of benefits to the volunteers, and of the practical considerations of conducting an intervention. Volunteers also discussed considerations for future research and services for older adults living alone. Volunteers found their involvement in the intervention to be personally beneficial, and revealed some valuable considerations for the researchers to take forward to future research. Results are pertinent to intervention design and could inform future social cognitive and other peer-oriented interventions for older adults living alone.

Climate change and the distribution and conservation of the world's highest elevation woodlands in the South American Altiplano

NASA Astrophysics Data System (ADS)

Cuyckens, G. A. E.; Christie, D. A.; Domic, A. I.; Malizia, L. R.; Renison, D.

2016-02-01

Climate change is becoming an increasing threat to biodiversity. Consequently, methods for delineation, establishment and management of protected areas must consider the species' future distribution in response to future climate conditions. Biodiversity in high altitude semiarid regions may be particularly threatened by future climate change. In this study we assess the main environmental variables that best explain present day presence of the world's highest elevation woodlands in the South American Altiplano, and model how climate change may affect the future distribution of this unique ecosystem under different climate change scenarios. These woodlands are dominated by Polylepis tarapacana (Rosaceae), a species that forms unique biological communities with important conservation value. Our results indicate that five environmental variables are responsible for 91% and 90.3% of the present and future P. tarapacana distribution models respectively, and suggest that at the end of the 21st century, there will be a significant reduction (56%) in the potential habitat for this species due to more arid conditions. Since it is predicted that P. tarapacana's potential distribution will be severely reduced in the future, we propose a new network of national protected areas across this species distribution range in order to insure the future conservation of this unique ecosystem. Based on an extensive literature review we identify research topics and recommendations for on-ground conservation and management of P. tarapacana woodlands.

Towards an Immunophenotype of Schizophrenia: Progress, Potential Mechanisms, and Future Directions

PubMed Central

Miller, Brian J; Goldsmith, David R

2017-01-01

The evidence to date, coupled with advances in immunology and genetics has afforded the field an unparalleled opportunity to investigate the hypothesis that a subset of patients with schizophrenia may manifest an immunophenotype, toward new potential diagnostics and therapeutics to reduce risk, alleviate symptoms, and improve quality of life in both at-risk populations and patients with established schizophrenia. In this paper, we will first summarize the findings on immune dysfunction in schizophrenia, including (1) genetic, prenatal, and premorbid immune risk factors and (2) immune markers across the clinical course of the disorder, including cytokines; C-reactive protein; immune cells; antibodies, autoantibodies and comorbid autoimmune disorders; complement; oxidative stress; imaging of neuroinflammation; infections; and clinical trials of anti-inflammatory agents and immunotherapy. We will then discuss a potential mechanistic framework toward increased understanding of a potential schizophrenia immunophenotype. We will then critically appraise the existing literature, and discuss suggestions for the future research agenda in this area that are needed to rigorously evaluate this hypothesis. PMID:27654215

Langley Research Center Utility Risk from Future Climate Change

NASA Technical Reports Server (NTRS)

De Young, Russell J.; Ganoe, Rene

2015-01-01

The successful operation of NASA Langley Research Center (LaRC) depends on services provided by several public utility companies. These include Newport News Waterworks, Dominion Virginia Power, Virginia Natural Gas and Hampton Roads Sanitation District. LaRC's plan to respond to future climate change should take into account how these companies plan to avoid interruption of services while minimizing cost to the customers. This report summarizes our findings from publicly available documents on how each company plans to respond. This will form the basis for future planning for the Center. Our preliminary findings show that flooding and severe storms could interrupt service from the Waterworks and Sanitation District but the potential is low due to plans in place to address climate change on their system. Virginia Natural Gas supplies energy to produce steam but most current steam comes from the Hampton trash burning plant, thus interruption risk is low. Dominion Virginia Power does not address climate change impacts on their system in their public reports. The potential interruption risk is considered to be medium. The Hampton Roads Sanitation District is projecting a major upgrade of their system to mitigate clean water inflow and infiltration. This will reduce infiltration and avoid overloading the pump stations and treatment plants.

Sleep Disturbances in Adolescents with ADHD: A Systematic Review and Framework for Future Research

PubMed Central

Lunsford-Avery, Jessica R.; Krystal, Andrew D.; Kollins, Scott H.

2016-01-01

Background Biological mechanisms underlying symptom and prognostic heterogeneity in Attention-Deficit/Hyperactivity Disorder (ADHD) are unclear. Sleep impacts neurocognition and daytime functioning and is disrupted in ADHD, yet little is known about sleep in ADHD during adolescence, a period characterized by alterations in sleep, brain structure, and environmental demands as well as diverging ADHD trajectories. Methods A systematic review identified studies published prior to August 2016 assessing sleep in adolescents (aged 10–19 years) with ADHD or participating in population-based studies measuring ADHD symptoms. Results Twenty-five studies were identified (19 subjective report, 6 using actigraphy/polysomnography). Findings are mixed but overall suggest associations between sleep disturbances and 1) ADHD symptoms in the population and 2) poorer clinical, neurocognitive, and functional outcomes among adolescents with ADHD. Common limitations of studies included small or non-representative samples, non-standardized sleep measures, and cross-sectional methodology. Conclusions Current data on sleep in adolescent ADHD are sparse and limited by methodological concerns. Future studies are critical for clarifying a potential role of sleep in contributing to heterogeneity of ADHD presentation and prognosis. Potential mechanisms by which sleep disturbances during adolescence may contribute to worsened symptom severity and persistence of ADHD into adulthood and an agenda to guide future research are discussed. PMID:27969004

Graphene Materials in Antimicrobial Nanomedicine: Current Status and Future Perspectives.

PubMed

Karahan, Hüseyin Enis; Wiraja, Christian; Xu, Chenjie; Wei, Jun; Wang, Yilei; Wang, Liang; Liu, Fei; Chen, Yuan

2018-03-05

Graphene materials (GMs), such as graphene, graphene oxide (GO), reduced GO (rGO), and graphene quantum dots (GQDs), are rapidly emerging as a new class of broad-spectrum antimicrobial agents. This report describes their state-of-the-art and potential future covering both fundamental aspects and biomedical applications. First, the current understanding of the antimicrobial mechanisms of GMs is illustrated, and the complex picture of underlying structure-property-activity relationships is sketched. Next, the different modes of utilization of antimicrobial GMs are explained, which include their use as colloidal dispersions, surface coatings, and photothermal/photodynamic therapy agents. Due to their practical relevance, the examples where GMs function as synergistic agents or release platforms for metal ions and/or antibiotic drugs are also discussed. Later, the applicability of GMs in the design of wound dressings, infection-protective coatings, and antibiotic-like formulations ("nanoantibiotics") is assessed. Notably, to support our assessments, the existing clinical applications of conventional carbon materials are also evaluated. Finally, the key hurdles of the field are highlighted, and several possible directions for future investigations are proposed. We hope that the roadmap provided here will encourage researchers to tackle remaining challenges toward clinical translation of promising research findings and help realize the potential of GMs in antimicrobial nanomedicine. © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Biomedical Scientific and Professional Social Networks in the Service of the Development of Modern Scientific Publishing.

PubMed

Masic, Izet; Begic, Edin

2016-12-01

Information technologies have found their application in virtually every branch of health care. In recent years they have demonstrated their potential in the development of online library, where scientists and researchers can share their latest findings. Academia.edu, ResearchGate, Mendeley, Kudos, with the support of platform GoogleScholar, have indeed increased the visibility of scientific work of one author, and enable a much greater availability of the scientific work to the broader audience. Online libraries have allowed free access to the scientific content to the countries that could not follow the economic costs of getting access to certain scientific bases. Especially great benefit occurred in countries in transition and developing countries. Online libraries have great potential in terms of expanding knowledge, but they also present a major problem for many publishers, because their rights can be violated, which are signed by the author when publishing the paper. In the future it will lead to a major conflict of the author, the editorial board and online database, about the right to scientific content This question certainly represents one of the most pressing issues of publishing, whose future in printed form is already in the past, and the future of the online editions will be a problem of large-scale.

NASA's Vision for Potential Energy Reduction from Future Generations of Propulsion Technology

NASA Technical Reports Server (NTRS)

Haller, Bill

2015-01-01

Through a robust partnership with the aviation industry, over the past 50 years NASA programs have helped foster advances in propulsion technology that enabled substantial reductions in fuel consumption for commercial transports. Emerging global trends and continuing environmental concerns are creating challenges that will very likely transform the face of aviation over the next 20-40 years. In recognition of this development, NASA Aeronautics has established a set of Research Thrusts that will help define the future direction of the agency's research technology efforts. Two of these thrusts, Ultra-Efficient Commercial Vehicles and Transition to Low-Carbon Propulsion, serve as cornerstones for the Advanced Air Transport Technology (AATT) project. The AATT project is exploring and developing high-payoff technologies and concepts that are key to continued improvement in energy efficiency and environmental compatibility for future generations of fixed-wing, subsonic transports. The AATT project is primarily focused on the N+3 timeframe, or 3 generations from current technology levels. As should be expected, many of the propulsion system architectures technologies envisioned for N+3 vary significantly from todays engines. The use of batteries in a hybrid-electric configuration or deploying multiple fans distributed across the airframe to enable higher bypass ratios are just two examples of potential advances that could enable substantial energy reductions over current propulsion systems.

Biomedical Scientific and Professional Social Networks in the Service of the Development of Modern Scientific Publishing

PubMed Central

Masic, Izet; Begic, Edin

2016-01-01

Information technologies have found their application in virtually every branch of health care. In recent years they have demonstrated their potential in the development of online library, where scientists and researchers can share their latest findings. Academia.edu, ResearchGate, Mendeley, Kudos, with the support of platform GoogleScholar, have indeed increased the visibility of scientific work of one author, and enable a much greater availability of the scientific work to the broader audience. Online libraries have allowed free access to the scientific content to the countries that could not follow the economic costs of getting access to certain scientific bases. Especially great benefit occurred in countries in transition and developing countries. Online libraries have great potential in terms of expanding knowledge, but they also present a major problem for many publishers, because their rights can be violated, which are signed by the author when publishing the paper. In the future it will lead to a major conflict of the author, the editorial board and online database, about the right to scientific content This question certainly represents one of the most pressing issues of publishing, whose future in printed form is already in the past, and the future of the online editions will be a problem of large-scale. PMID:28077905

Telehealth innovations in health education and training.

PubMed

Conde, José G; De, Suvranu; Hall, Richard W; Johansen, Edward; Meglan, Dwight; Peng, Grace C Y

2010-01-01

Telehealth applications are increasingly important in many areas of health education and training. In addition, they will play a vital role in biomedical research and research training by facilitating remote collaborations and providing access to expensive/remote instrumentation. In order to fulfill their true potential to leverage education, training, and research activities, innovations in telehealth applications should be fostered across a range of technology fronts, including online, on-demand computational models for simulation; simplified interfaces for software and hardware; software frameworks for simulations; portable telepresence systems; artificial intelligence applications to be applied when simulated human patients are not options; and the development of more simulator applications. This article presents the results of discussion on potential areas of future development, barries to overcome, and suggestions to translate the promise of telehealth applications into a transformed environment of training, education, and research in the health sciences.

Modelling the Impacts of Changing Land Cover/Land Use and Climate on Flooding in the Elk River Watershed, British Columbia

NASA Astrophysics Data System (ADS)

Barnes, C. C.; Byrne, J. M.; Hopkinson, C.; MacDonald, R. J.; Johnson, D. L.

2015-12-01

The Elk River is a mountain watershed located along the eastern border of British Columbia, Canada. The Elk River is confined by railway bridges, roads, and urban areas. Flooding has been a concern in the valley for more than a century. The most recent major flood event occurred in 2013 affecting several communities. River modifications such as riprapped dykes, channelization, and dredging have occurred in an attempt to reduce inundation, with limited success. Significant changes in land cover/land use (LCLU) such as natural state to urban, forestry practices, and mining from underground to mountaintop/valley fill have changed terrain and ground surfaces thereby altering water infiltration and runoff processes in the watershed. Future climate change in this region is expected to alter air temperature and precipitation as well as produce an earlier seasonal spring freshet potentially impacting future flood events. The objective of this research is to model historical and future hydrological conditions to identify flood frequency and risk under a range of climate and LCLU change scenarios in the Elk River watershed. Historic remote sensing data, forest management plans, and mining industry production/post-mining reclamation plans will be used to create a predictive past and future LCLU time series. A range of future air temperature and precipitation scenarios will be developed based on accepted Global Climate Modelling (GCM) research to examine how the hydrometeorological conditions may be altered under a range of future climate scenarios. The GENESYS (GENerate Earth SYstems Science input) hydrometeorological model will be used to simulate climate and LCLU to assess historic and potential future flood frequency and magnitude. Results will be used to create innovative flood mitigation, adaptation, and management strategies for the Elk River with the intent of being wildlife friendly and non-destructive to ecosystems and habitats for native species.

University-Government Partnerships and High Risk Research: The Last Stronghold for New Thinking About Coping with Climate Change

NASA Astrophysics Data System (ADS)

Easterling, W. E.

2014-12-01

The repurposing of Bell Laboratories by new owner Lucent Technologies to become a mission-focused applied research facility effectively terminated fundamental, high-risk research everywhere but in research universities. The now almost ten year old NAS study that produced the watershed report Rising Above the Gathering Storm warned that the US research establishment encompassing industry, government, academia and nongovernment organizations has lost its way in promoting fundamental high-risk research of the kind that has historically led to the transformational scientific breakthroughs that radically changed and improved our quality of life for more than a century. Low-risk, incremental research dominates industry and most government funding agendas, including NSF (and including NSF's "transformational research" agenda!). Unprecedented challenges such as understanding and dealing with the consequences of climate change will require fundamental new ideas and technologies that do not exist. Adapting future ecosystems and human systems to climate variability and change needs new social models of cooperation, new biotechnologies and new environmental mangement strategies that do not now exist. A case can be made that history provides no strong templates for such a future. I argue that research universities, working in close partnerships with government, provides a fertile seedbed for the kinds of scientific knowledge and thinking that could produce "game changing" strategies for dealing with climate change. Government has the resources and the ability to convert and scale new ideas into usable knowledge, research universities have the ingenuity and disciplinary spectra to think up new ideas and test them for proof of concept. Co-locating a government presence within a research university has the potential to integrate a research enterprise that is not afraid to fail a few times before potentially hitting paydirt with an institution that can accelerate the translation of fundamental scientific breakthroughs into new usable information. Examples of how this has worked in other scientific settings will be presented to show the potential of this type of collaboration for dealing with climate change.

The role of social networking sites in medical genetics research.

PubMed

Reaves, Allison Cook; Bianchi, Diana W

2013-05-01

Social networking sites (SNS) have potential value in the field of medical genetics as a means of research subject recruitment and source of data. This article examines the current role of SNS in medical genetics research and potential applications for these sites in future studies. Facebook is the primary SNS considered, given the prevalence of its use in the United States and role in a small but growing number of studies. To date, utilization of SNS in medical genetics research has been primarily limited to three studies that recruited subjects from populations of Facebook users [McGuire et al. (2009); Am J Bioeth 9: 3-10; Janvier et al. (2012); Pediatrics 130: 293-298; Leighton et al. (2012); Public Health Genomics 15: 11-21]. These studies and a number of other medical and public health studies that have used Facebook as a context for recruiting research subjects are discussed. Approaches for Facebook-based subject recruitment are identified, including paid Facebook advertising, snowball sampling, targeted searching and posting. The use of these methods in medical genetics research has the potential to facilitate cost-effective research on both large, heterogeneous populations and small, hard-to-access sub-populations. Copyright © 2013 Wiley Periodicals, Inc.

Perceived stress among 20-21 year-olds and their future labour market participation - an eight-year follow-up study.

PubMed

Trolle, Nanna; Lund, Thomas; Winding, Trine Nohr; Labriola, Merete

2017-03-31

Labour market participation among young adults is essential for their future socioeconomic status and health. The aim of this study was to investigate the association between perceived stress among 20-21 year-olds and their labour market participation 8 years later as well as investigate any potential gender differences. A cohort of 1640 young adults born in 1983 completed a questionnaire in 2004 in which perceived stress was measured. The cohort was followed in a register of social benefits for 12 months in 2011-2012 and was categorized into active and passive labour market participation. Logistic regression was used to analyse the association between perceived stress and future labour market participation, taking into account effects of potential confounders. The analyses were stratified by gender. The effects of perceived stress on future labour market participation differed significantly among young women and young men (p = 0.029). For young men, higher levels of perceived stress reduced the risk of future passive labour market participation, when adjusting for socioeconomic factors, self-rated health and copings strategies (p = 0.045). For young women, higher levels of perceived stress increased the risk of future passive labour market participation, when adjusting for the same potential confounding factors, although unlike the men, this association was not statistically significant (p = 0.335). The observed gender difference has important implications from a public health point of view. Healthcare professionals might need to differentiate between the genders in terms of health communication, research and when developing preventive strategies.

Research Performed within the Non-Destructive Evaluation Team at NASA Glenn Research Center

NASA Technical Reports Server (NTRS)

Burns, Erin A.

2004-01-01

Non-destructive testing is essential in many fields of manufacturing and research in order to perform reliable examination of potentially damaged materials and parts without destroying the inherent structure of the materials. Thus, the Non-Destructive Evaluation (NDE) Team at NASA Glenn Research Center partakes in various projects to improve materials testing equipment as well as analyze materials, material defects, and material deficiencies. Due to the array of projects within the NDE Team at this time, five research aims were supplemental to some current projects. A literature survey of "DE and testing methodologies as related to rocks was performed. Also, Mars Expedition Rover technology was assessed to understand the requirements for instrumentation in harsh space environments (e.g. temperature). Potential instrumentation and technologies were also considered and documented. The literature survey provided background and potential sources for a proposal to acquire funding for ultrasonic instrumentation on board a future Mars expedition. The laboratory uses a Santec Systems AcousticScope AS200 acoustography system. Labview code was written within the current program in order to improve the current performance of the acoustography system. A sample of Reinforced Carbon/Carbon (RCC) material from the leading edge of the space shuttle underwent various non-destructive tests (guided wave scanning, thermography, computed tomography, real time x-ray, etc.) in order to characterize its structure and examine possible defects. Guided wave scan data of a ceramic matrix composite (CMC) panel was reanalyzed utilizing image correlations and signal processing variables. Additional guided wave scans and thermography were also performed on the CMC panel. These reevaluated data and images will be used in future presentations and publications. An additional axis for the guided wave scanner was designed, constructed, and implemented. This additional axis allowed incremental spacing of the previously fixed transducers for ultrasonic velocity measurements.

Spinal cord injury (SCI) rehabilitation: systematic analysis of communication from the biopsychosocial perspective.

PubMed

Hartley, Naomi A

2015-07-02

Communication is powerful predictor of health-related quality of life and overall well-being, yet its role in promoting rehabilitation outcomes in spinal cord injury (SCI) is rarely mentioned. This article systematically analyzes and synthesizes literature from multiple disciplines according to a biopsychosocial perspective, providing an evidence base for clinical practice and clear direction for future research. Systematic literature review and analysis, incorporating mapping to International Classification of Functioning, Disability and Health (ICF) codes. In total 4338 entries were retrieved from CINAHL, PsychInfo, Medline, PubMed and SpeechBite databases for the period 1990-2014. A total of 115 treatment and observational studies (quantitative and qualitative) detailed aspects of communication according to structure, function, activity, participation and environmental factors; evident of the complex interactions between communicative function with daily living after SCI. Communication is a relative strength in SCI, key to empowerment, independence, social interaction, and well-being, yet its potential to enhance SCI rehabilitation outcomes remains largely underexplored and untapped. Through elucidating interactions between communication and functioning, the adapted ICF framework affords clinicians and researchers insight into areas of intervention most likely to result in widespread gains. Conscious consideration should be given to the role of communication, within an integrative, strengths-based, multidisciplinary approach to clinical practice and future research. Implications for Rehabilitation Communication fosters empowerment, independence and greater participation in life roles; recognized as a powerful predictor of health-related quality of life and overall well-being. The ICF framework elucidates influences to communicative function, and components which are influenced by communication, providing valuable insight for clinicians and researchers. Therapeutic and research endeavors guided by existing ICF core sets are at risk of failing to consider communication, thereby limiting rehabilitation outcomes. Tapping the potential of communication as a relative strength within SCI rehabilitation holds considerable promise, within integrative, strengths-based, multidisciplinary approaches to clinical practice and future research.

Report from the second international symposium on animal genomics for animal health: critical needs, challenges and potential solutions.

PubMed

Bishop, Steve C; Lunney, Joan K; Pinard-van der Laan, Marie-Hélène; Gay, Cyril G

2011-06-03

The second International Symposium on Animal Genomics for Animal Health held in Paris, France 31 May-2 June, 2010, assembled more than 140 participants representing research organizations from 40 countries. The symposium included a roundtable discussion on critical needs, challenges and opportunities, and a forward look at the potential applications of animal genomics in animal health research. The aim of the roundtable discussion was to foster a dialogue between scientists working at the cutting edge of animal genomics research and animal health scientists. Importantly, stakeholders were included to provide input on priorities and the potential value of animal genomics to the animal health community. In an effort to facilitate the roundtable discussion, the organizers identified four priority areas to advance the use of genome-enabled technologies in animal health research. Contributions were obtained through open discussions and a questionnaire distributed at the start of the symposium. This report provides the outcome of the roundtable discussion for each of the four priority areas. For each priority, problems are identified, including potential solutions and recommendations. This report captures key points made by symposium participants during the roundtable discussion and serves as a roadmap to steer future research priorities in animal genomics research.

Taking a Stand: The Genetics Community's Responsibility for Intelligence Research.

PubMed

Callier, Shawneequa L; Bonham, Vence L

2015-01-01

There is a longstanding debate about genetics research into intelligence. Some scholars question the value of focusing on genetic contributions to intelligence in a society where social and environmental determinants powerfully influence cognitive ability and educational outcomes. Others warn that censoring certain research questions, such as inquiries about genetic differences in intellectual potential, compromises academic freedom. Still others view interest in this subject as a corollary to a long and troublesome history of eugenics research. The dawn of a new era in genome sequencing as a commodity will sustain scientific interest in the genetics of intelligence for the foreseeable future, but deep-rooted challenges threaten the scientific merit of the research. The use of imprecise definitions of study populations, the difficult nature of studying the environment, and the potential of researcher bias are inextricably linked with concerns about the trustworthiness and utility of research in this area. Leadership by the genetics community is essential to ensure the value and trustworthiness of these studies. © 2015 The Hastings Center.

Challenges of Conducting Research With Young Offenders With Traumatic Brain Injury.

PubMed

OʼRourke, Conall; Templeton, Michelle; Cohen, Miriam H; Linden, Mark A

2018-05-31

The purpose of this commentary is to highlight the challenges encountered when conducting research with young offenders. This is drawn from the first-hand experience of 3 researchers working on separate projects within this environment. Young offenders present as a complex clinical population with high levels of illiteracy, substance abuse, and mental health issues. Significant planning is therefore required before working with this group. Consideration must be given to the heterogeneity of prison populations alongside the potential limitations of datacollection methods, in particular, reliance on self-report. The capacity of young offenders to comprehend and effectively engage with research is also of concern, posing issues of both a practical and ethical nature. The absence of a consistent "research culture" within prison environments poses further practical challenges, potentially also placing significant burden on both researchers and prison resources. The challenges discussed in this article may help inform future studies in the area and emphasize the need for greater critical reflection among researchers conducting work of this type.

Informatics Futures in Dental Education and Research: Quality Assurance.

ERIC Educational Resources Information Center

Crall, James J.

1991-01-01

The paper addresses the potential of informatics to patient care quality assurance curricula, focusing on (1) terminology and developments related to quality of care evaluations; (2) criticisms of traditional approaches; (3) limitations of existing data sources for quality assurance in dentistry; and (4) quality assurance considerations in…

POLLUTION FROM THE COMBINED ACTIVITIES, ACTIONS ...

EPA Pesticide Factsheets

ORD's four-fold objectives in its efforts have been to: (i) Identify potential (future) environmental concerns (anticipatory research and identification of emerging issues, especially to identify pivotal sources of uncertainty that might affect risk estimates), (ii) Be proactive versus reactive (allowing for pollution prevention versus remediation/restoration; identify and foster investigation of

["Big data" - large data, a lot of knowledge?].

PubMed

Hothorn, Torsten

2015-01-28

Since a couple of years, the term Big Data describes technologies to extract knowledge from data. Applications of Big Data and their consequences are also increasingly discussed in the mass media. Because medicine is an empirical science, we discuss the meaning of Big Data and its potential for future medical research.

Challenges and Solutions When Using Technologies in the Classroom

ERIC Educational Resources Information Center

Johnson, Amy M.; Jacovina, Matthew E.; Russell, Devin G.; Soto, Christian M.

2016-01-01

The purpose of this chapter is to present common challenges faced by educators when attempting to integrate technology in the classroom, and offer potential solutions to those problems. Examination of these issues should be valuable to current and future educators, school administrators, as well as educational technology researchers. The chapter…

Optical Information Processing for Aerospace Applications 2

NASA Technical Reports Server (NTRS)

Stermer, R. L. (Compiler)

1984-01-01

Current research in optical processing, and determination of its role in future aerospace systems was reviewed. It is shown that optical processing offers significant potential for aircraft and spacecraft control, pattern recognition, and robotics. It is demonstrated that the development of optical devices and components can be implemented in practical aerospace configurations.

Context-Aware Recommender Systems for Learning: A Survey and Future Challenges

ERIC Educational Resources Information Center

Verbert, K.; Manouselis, N.; Ochoa, X.; Wolpers, M.; Drachsler, H.; Bosnic, I.; Duval, E.

2012-01-01

Recommender systems have been researched extensively by the Technology Enhanced Learning (TEL) community during the last decade. By identifying suitable resources from a potentially overwhelming variety of choices, such systems offer a promising approach to facilitate both learning and teaching tasks. As learning is taking place in extremely…

Humic products in agriculture: Potential benefits and research challenges-a review

USDA-ARS?s Scientific Manuscript database

Humic products have been used in cropland agriculture for several decades, but lack of widespread credibility has restricted their use to small proportions of farmers. To improve the credibility of humic products, we identify four knowledge gaps and propose pathways of future action to close these g...

Ethical Approaches to Compliance

ERIC Educational Resources Information Center

Buzo, Carina

2017-01-01

This article explores the role that higher education has in ethical compliance to Title IX and the Clery Act. The discussion includes a curious look at common practices as potential future approaches to consent and sexual assault education. Articles and research are included to ground understanding in the current context, while examples from a…

Characterization and development of truck load spectra and growth factors for current and future pavement design practices in Louisiana.

DOT National Transportation Integrated Search

2011-07-01

This research study primarily addresses the current traffic characterization techniques used in Louisiana for pavement design practices in order to identify critical changes needed as well as certain gaps and areas of potential development in the tra...

Does (In)Formal Learning Enhance Employability?

ERIC Educational Resources Information Center

van der Heijden, Beatrice I.J.M.; Boon, Jo; van der Klink, Marcel R.; Meys, Ely

2008-01-01

Not much is known about the actual contribution of informal learning to employability over and above formal learning activities. This paper presents findings of a research project among university staff members and is aimed to determine the contribution of formal and informal learning activities in the light of future career potential. Findings…

Compound Complementarities in the Study of Motivated Behavior.

ERIC Educational Resources Information Center

Teitelbaum, Philip; Stricker, Edward M.

1994-01-01

The 1954 article by Eliot Stellar provided the theoretical focus for a great deal of research on the biological bases of human behavior. Future attention to the infrastructure of behaviors being studied, combined with reductionistic studies of neurons, will fulfill the potential contribution to behavioral neuroscience implicit in Stellar's…

Black Men in the Medical Education Pipeline: Past, Present, and Future.

ERIC Educational Resources Information Center

Ready, Timothy; Nickens, Herbert W.

1991-01-01

Factors in the decline in Black male enrollment in medical schools are examined, including the general medical school applicant pool, popularity of undergraduate biology degrees, Black enrollment in college, poverty, and employment opportunities. Social implications, areas for further research, and potential solutions are discussed. (Author/MSE)

Studying Teachers and Schools: Michael Pressley's Legacy and Directions for Future Research

ERIC Educational Resources Information Center

Mohan, Lindsey; Lundeberg, Mary A.; Reffitt, Kelly

2008-01-01

Much of Michael Pressley's work during the past decade focused on the nature of highly effective, engaging literacy instruction. Michael Pressley believed that studying effective teachers and schools had the potential to influence more engaging and effective teaching, especially in underresourced schools. First, we describe the grounded…

Lavandula angustifolia Miller: English lavender.

PubMed

Denner, Sallie Stoltz

2009-01-01

Folk and traditional therapeutic use of the essential oil of English lavender for pain, infection, relaxation, and sedation dates back centuries. Current research focusing on the inherent synergism of Lavandula angustifolia Miller demonstrates great potential for future applications. Today's investigations may provide the key to eradicating degenerative inflammatory disease, infectious disease, and carcinogenesis.

Teaching, Learning, and Sharing Openly Online

ERIC Educational Resources Information Center

O'Byrne, W. Ian; Roberts, Verena; LaBonte, Randy; Graham, Lee

2015-01-01

Open learning is becoming a critical focus for K-12 technology-supported programs as the importance of digital literacy and digital freedoms for all learners grows. This article describes current open learning policy, open educational resources and potential implications for open practice and ends with suggestions for future research in open…

The New Literacies of Online Reading Comprehension: Future Directions

ERIC Educational Resources Information Center

Coiro, Julie

2012-01-01

Research in four areas has the potential to dramatically improve how practitioners address the challenges of integrating digital texts and tasks into their literacy curriculum. Advances in defining and measuring key components of online reading comprehension are rapidly emerging. In addition, instructional models, such as Internet reciprocal…

E-Roadway Animation | Transportation Research | NREL

Science.gov Websites

E-Roadway Animation E-Roadway Animation This animation depicts a potential future transportation scenario in which electric vehicles can be recharged via electrified roadways. E-roadways offer a variety operational range of electric vehicles. Plus, e-roadway power can come from renewable sources. Text version.

Human Resource Implications of Robotics.

ERIC Educational Resources Information Center

Hunt, H. Allan; Hunt, Timothy L.

A study examined the job creation and job displacement potential of industrial robots in the United States and specifically, in Michigan, by 1990. To complete an analysis of the impact of robotics on the American labor force, researchers combined data from previous forecasts of future unit and dollar sales projections and from interviews with…

Psychological Pathways Linking Social Support to Health Outcomes: A Visit with the “Ghosts” of Research Past, Present, and Future

PubMed Central

Uchino, Bert N.; Bowen, Kimberly; Carlisle, McKenzie; Birmingham, Wendy

2012-01-01

Contemporary models postulate the importance of psychological mechanisms linking perceived and received social support to physical health outcomes. In this review, we examine studies that directly tested the potential psychological mechanisms responsible for links between social support and health-relevant physiological processes (1980s to 2010). Inconsistent with existing theoretical models, no evidence was found that psychological mechanisms such as depression, perceived stress, and other affective processes are directly responsible for links between support and health. We discuss the importance of considering statistical/design issues, emerging conceptual perspectives, and limitations of our existing models for future research aimed at elucidating the psychological mechanisms responsible for links between social support and physical health outcomes. PMID:22326104

Mindfulness-Based Interventions for Older Adults: A Review of the Effects on Physical and Emotional Well-being

PubMed Central

Geiger, Paul J.; Boggero, Ian A.; Brake, C. Alex; Caldera, Carolina A.; Combs, Hannah L.; Peters, Jessica R.; Baer, Ruth A.

2015-01-01

This comprehensive review examined the effects of mindfulness-based interventions on the physical and emotional wellbeing of older adults, a rapidly growing segment of the general population. Search procedures yielded 15 treatment outcome studies meeting inclusion criteria. Support was found for the feasibility and acceptability of mindfulness-based interventions with older adults. Physical and emotional wellbeing outcome variables offered mixed support for the use of mindfulness-based interventions with older adults. Potential explanations of mixed findings may include methodological flaws, study limitations, and inconsistent modifications of protocols. These are discussed in detail and future avenues of research are discussed, emphasizing the need to incorporate geriatric populations into future mindfulness-based empirical research. PMID:27200109

A theoretical flaw in the advance market commitment idea.

PubMed

Sonderholm, Jorn

2010-06-01

Infectious and parasitic diseases cause massive health problems in the developing world. Research and development of drugs for diseases that mainly affect poor people in developing countries is limited. The advance market commitment (AMC) idea is an incentivising mechanism for research and development of drugs for neglected diseases. Discussion of the AMC idea is of renewed interest given the launch in June 2009 of the first AMC. This pilot AMC is designed to, among other things, test the idea for potential future applications. This paper is a critique of the AMC idea. It seeks to show that the idea has a hitherto unrecognised theoretical flaw that should make policy-makers and donors hesitant to embrace future applications of the idea.

The Value of Biomedical Simulation Environments to Future Human Space Flight Missions

NASA Technical Reports Server (NTRS)

Mulugeta,Lealem; Myers, Jerry G.; Lewandowski, Beth; Platts, Steven H.

2011-01-01

Mars and NEO missions will expose astronaut to extended durations of reduced reduced gravity, isolation and higher radiation. These new operation conditions pose health risks that are not well understood and perhaps unanticipated. Advanced computational simulation environments can beneficially augment research to predict, assess and mitigate potential hazards to astronaut health. The NASA Digital Astronaut Project (DAP), within the NASA Human Research Program, strives to achieve this goal.

Advanced powder metallurgy aluminum alloys and composites

NASA Technical Reports Server (NTRS)

Lisagor, W. B.; Stein, B. A.

1982-01-01

The differences between powder and ingot metallurgy processing of aluminum alloys are outlined. The potential payoff in the use of advanced powder metallurgy (PM) aluminum alloys in future transport aircraft is indicated. The national program to bring this technology to commercial fruition and the NASA Langley Research Center role in this program are briefly outlined. Some initial results of research in 2000-series PM alloys and composites that highlight the property improvements possible are given.

Adhesives: Test Method, Group Assignment, and Categorization Guide for High-Loading-Rate Applications

DTIC Science & Technology

2014-06-01

CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) Robert Jensen, Daniel DeSchepper, David Flanagan, Wendy Kosik...lessons learned , or research purposes; these are generally long-term records.” Records will be kept in physical laboratory notebooks and digitally... learned ” could have potential value in addressing future research focus. Testing progression protocols beyond the third tier are intended for ARL

Kaufman thruster development at Lewis Research Center

NASA Technical Reports Server (NTRS)

Kerslake, W. R.; Reader, P. D.

1971-01-01

The current status of research programs on mercury electron-bombardment thrusters is reviewed. Future thruster requirements predicted from mission analysis are briefly discussed to establish the relationship with present programs. Thrusters ranging in size from 5 to 150 cm diameter are described. These thrusters have possible near to far term applications extending from station keeping to primary propulsion. Beam currents range from 10 mA to 25 A at accelerating potentials of 500 to 5000 V.

Future directions of multiple behavior change research.

PubMed

Geller, Karly; Lippke, Sonia; Nigg, Claudio R

2017-02-01

Non-communicable diseases (i.e., chronic diseases including cardiovascular disease, cancer, chronic respiratory disease, diabetes and obesity) result in 36 million deaths each year. Individuals' habitual participation in a single health-risk behaviors substantially contribute to morbidity and mortality (e.g., tobacco use, daily fast food intake, etc.); however, more concerning is the impact of typically co-occurring or clustering of multiple health-risk behaviors. This burden can be minimized through successful cessation of health-risk behaviors and adoption of healthy behaviors; namely healthy lifestyle adoption or multiple health behavior change (MHBC). MHBC is a developing field and future research recommendations are provided to advance MHBC research. A valid measure of MHBC (i.e., lifestyle) is warranted to provide the needed basis for MHBC investigations and evaluations. MHBC is thought to occur through shared co-variation of underlying motivating mechanisms, but how these relationships influence behavior remains unclear. A better understanding of the relationship between behaviors and the related motivating mechanisms (and potential cross-relationship of influences) is needed. Future research should also aim to improve lifestyles through understanding how to change multiple health behaviors. Finally, MHBC research should target the development of sustainable interventions which result in lasting effects (e.g., capacity, systems, policy and environmental changes), with dissemination considered during development. Focusing MHBC research in these areas will increase our understanding and maximize the impact on the health of populations.

Aging, the Central Nervous System, and Mobility in Older Adults: Interventions

PubMed Central

Hausdorff, Jeffrey M.; Studenski, Stephanie A.; Rosano, Caterina; Camicioli, Richard; Alexander, Neil B.; Chen, Wen G.; Lipsitz, Lewis A.; Carlson, Michelle C.

2016-01-01

Background: Research suggests that the central nervous system (CNS) and mobility are closely linked. CNS-mediated mobility impairment may represent a potentially new and prevalent syndrome within the older adult populations. Interventions targeting this group may have the potential to improve mobility and cognition and prevent disability. Methods: In 2012, the Gerontological Society of America (GSA) and the National Institute on Aging (NIA) sponsored a 3-year conference workshop series, “Aging, the CNS, and Mobility.” The goal of this third and final conference was to (i) report on the state of the science of interventions targeting CNS-mediated mobility impairment among community-dwelling older adults and (ii) partnering with the NIA, explore the future of research and intervention design focused on a potentially novel aging syndrome. Results: Evidence was presented in five main intervention areas: (i) pharmacology and diet; (ii) exercise; (iii) electrical stimulation; (iv) sensory stimulation/deprivation; and (v) a combined category of multimodal interventions. Workshop participants identified important gaps in knowledge and key recommendations for future interventions related to recruitment and sample selection, intervention design, and methods to measure effectiveness. Conclusions: In order to develop effective preventive interventions for this prevalent syndrome, multidisciplinary teams are essential particularly because of the complex nature of the syndrome. Additionally, integrating innovative methods into the design of interventions may help researchers better measure complex mechanisms, and finally, the value of understanding the link between the CNS and mobility should be conveyed to researchers across disciplines in order to incorporate cognitive and mobility measurements into study protocols. PMID:27154905

The Future Workforce in Cancer Prevention: Advancing Discovery, Research, and Technology

PubMed Central

Newhauser, Wayne. D.; Scheurer, Michael. E.; Faupel-Badger, Jessica. M.; Clague, Jessica.; Weitzel, Jeffrey.; Woods, Kendra. V.

2012-01-01

As part of a 2 day conference on October 15 and 16, 2009, a nine-member task force composed of scientists, clinicians, educators, administrators, and students from across the United States was formed to discuss research, discovery, and technology obstacles to progress in cancer prevention and control, specifically those related to the cancer prevention workforce. This article summarizes the task force’s findings on the current state of the cancer prevention workforce in this area and its needs for the future. The task force identified two types of barriers impeding the current cancer prevention workforce in research, discovery, and technology from reaching its fullest potential: 1) limited cross-disciplinary research opportunities with underutilization of some disciplines is hampering discovery and research in cancer prevention, and 2) new research avenues are not being investigated because technology development and implementation are lagging. Examples of impediments and desired outcomes are provided in each of these areas. Recommended solutions to these problems are based on the goals of enhancing the current cancer prevention workforce and accelerating the pace of discovery and clinical translation. PMID:22314794

[Integrated approach to the promotion of young academics in vision research at a European level].

PubMed

Wheeler-Schilling, T H; Zrenner, E; Schiefer, U

2006-02-01

The European Commission predicts a dramatic dearth of researchers and doctors in the near future. At the same time, highly qualified and motivated human resources form the only guarantee for further development of scientific knowledge for research and clinical application. This situation calls for an integrated approach to the promotion of young academics in vision research at a European level. The Marie Curie Program of the European Union is an ideal tool, which can be used particularly efficiently in vision research to promote international networking and dedicated advancement of young academics. The exemplary chances and opportunities of this strategy can be demonstrated by six specific measures of the University Eye Hospital in Tübingen. In particular, strictly defined medical areas will need to fully exploit their innovation potential in the future in order to secure their position in the global research area or even to expand it. New organizational concepts and long-term career options as well as a clear commitment to cutting-edge performance are the prerequisites for effective promotion of young academics.

The future workforce in cancer prevention: advancing discovery, research, and technology.

PubMed

Newhauser, Wayne D; Scheurer, Michael E; Faupel-Badger, Jessica M; Clague, Jessica; Weitzel, Jeffrey; Woods, Kendra V

2012-05-01

As part of a 2-day conference on October 15 and 16, 2009, a nine-member task force composed of scientists, clinicians, educators, administrators, and students from across the USA was formed to discuss research, discovery, and technology obstacles to progress in cancer prevention and control, specifically those related to the cancer prevention workforce. This article summarizes the task force's findings on the current state of the cancer prevention workforce in this area and its needs for the future. The task force identified two types of barriers impeding the current cancer prevention workforce in research, discovery, and technology from reaching its fullest potential: (1) limited cross-disciplinary research opportunities with underutilization of some disciplines is hampering discovery and research in cancer prevention, and (2) new research avenues are not being investigated because technology development and implementation are lagging. Examples of impediments and desired outcomes are provided in each of these areas. Recommended solutions to these problems are based on the goals of enhancing the current cancer prevention workforce and accelerating the pace of discovery and clinical translation.

Projected changes in daily fire spread across Canada over the next century

NASA Astrophysics Data System (ADS)

Wang, Xianli; Parisien, Marc-André; Taylor, Steve W.; Candau, Jean-Noël; Stralberg, Diana; Marshall, Ginny A.; Little, John M.; Flannigan, Mike D.

2017-02-01

In the face of climate change, predicting and understanding future fire regimes across Canada is a high priority for wildland fire research and management. Due in large part to the difficulties in obtaining future daily fire weather projections, one of the major challenges in predicting future fire activity is to estimate how much of the change in weather potential could translate into on-the-ground fire spread. As a result, past studies have used monthly, annual, or multi-decadal weather projections to predict future fires, thereby sacrificing information relevant to day-to-day fire spread. Using climate projections from the fifth phase of the Coupled Model Intercomparison Project (CMIP5), historical weather observations, MODIS fire detection data, and the national fire database of Canada, this study investigated potential changes in the number of active burning days of wildfires by relating ‘spread days’ to patterns of daily fire-conducive weather. Results suggest that climate change over the next century may have significant impacts on fire spread days in almost all parts of Canada’s forested landmass; the number of fire spread days could experience a 2-to-3-fold increase under a high CO2 forcing scenario in eastern Canada, and a greater than 50% increase in western Canada, where the fire potential is already high. The change in future fire spread is critical in understanding fire regime changes, but is also imminently relevant to fire management operations and in fire risk mitigation.

Ethical challenges in developing an educational video to empower potential participants during consent processes in HIV cure research in South Africa.

PubMed

Staunton, Ciara; de Roubaix, Malcolm; Baatjies, Dianno; Black, Gill; Hendricks, Melany; Rossouw, Theresa; Moodley, Keymanthri

2018-04-01

Obtaining consent for HIV research is complex, particularly in low- and middle-income countries. Low levels of education, complexity of science and research processes, confusion about basic elements of research, and socio-economic conditions that make access to medical care difficult have collectively led to concerns about the adequacy of the consent process. Given the exponential growth of HIV prevention and treatment research in South Africa, HIV researchers are increasingly facing challenges obtaining authentic informed consent from potential participants. It is anticipated that HIV cure research, despite being in its infancy in South Africa, will introduce a new discourse into a population that is often struggling to understand the differences between 'cure', 'preventive and therapeutic vaccines' and other elements of the research process. Coupled with this, South Africa has a complex history of 'illegitimate' or 'false cures' for HIV. It is therefore logical to anticipate that HIV cure research may face significant challenges during consent processes. HIV prevention research in South Africa has demonstrated the importance of early community engagement in educating potential research participants and promoting community acceptance of research. Consequently, in an attempt to extrapolate from this experience of engaging with communities early regarding cure research, a 15-minute educational video entitled ' I have a dream: a world without HIV ' was developed to educate and ultimately empower potential research participants to make informed choices during consent processes in future HIV cure clinical trials. To aid others in the development of educational interventions, this paper discusses the challenges faced in developing this educational video.

Authentic leadership in healthcare: a scoping review.

PubMed

Malila, Niina; Lunkka, Nina; Suhonen, Marjo

2018-02-05

Purpose The purpose of this paper is to review peer-reviewed original research articles on authentic leadership (AL) in health care to identify potential research gaps and present recommendations for future research. The objectives are to examine and map evidence of the main characteristics, research themes and methodologies in the studies. AL is a leader's non-authoritarian, ethical and transparent behaviour pattern. Design/methodology/approach A scoping review with thematic analysis was conducted. A three-step search strategy was used with database and manual searches. The included studies were composed of English language peer-reviewed original research articles referring to both AL and health care. Findings In total, 29 studies were included. The studies favoured Canadian nurses in acute care hospitals. AL was understood as its original definition. The review identified four research themes: well-being at work, patient care quality, work environment and AL promotion. Quantitative research methodology with the authentic leadership questionnaire and cross-sectional design were prevalent. Research limitations/implications Future research needs more variation in research themes, study populations, settings, organisations, work sectors, geographical origins and theory perspectives. Different research methodologies, such as qualitative and mixed methods research and longitudinal designs, should be used more. Originality/value This is presumably the first literature review to map the research on AL in health care.

Effective stakeholder participation in setting research priorities using a Global Evidence Mapping approach.

PubMed

Clavisi, Ornella; Bragge, Peter; Tavender, Emma; Turner, Tari; Gruen, Russell L

2013-05-01

We present a multistep process for identifying priority research areas in rehabilitation and long-term care of traumatic brain-injured (TBI) patients. In particular, we aimed to (1) identify which stakeholders should be involved; (2) identify what methods are appropriate; (3) examine different criteria for the generation of research priority areas; and (4) test the feasibility of linkage and exchange among researchers, decision makers, and other potential users of the research. Potential research questions were identified and developed using an initial scoping meeting and preliminary literature search, followed by a facilitated mapping workshop and an online survey. Identified research questions were then prioritized against specific criteria (clinical importance, novelty, and controversy). Existing evidence was then mapped to the high-priority questions using usual processes for search, screening, and selection. A broad range of stakeholders were then brought together at a forum to identify priority research themes for future research investment. Using clinical and research leaders, smaller targeted planning workshops prioritized specific research projects for each of the identified themes. Twenty-six specific questions about TBI rehabilitation were generated, 14 of which were high priority. No one method identified all high-priority questions. Methods that relied solely on the views of clinicians and researchers identified fewer high-priority questions compared with methods that used broader stakeholder engagement. Evidence maps of these high-priority questions yielded a number of evidence gaps. Priority questions and evidence maps were then used to inform a research forum, which identified 12 priority themes for future research. Our research demonstrates the value of a multistep and multimethod process involving many different types of stakeholders for prioritizing research to improve the rehabilitation outcomes of people who have suffered TBI. Enhancing stakeholder representation can be augmented using a combination of methods and a process of linkage and exchange. This process can inform decisions about prioritization of research areas. Copyright © 2013 Elsevier Inc. All rights reserved.

Applications of Optical Neuroimaging in Usability Research

PubMed Central

Hill, Audrey P.; Bohil, Corey J.

2016-01-01

FEATURE AT A GLANCE In this article we review recent and potential applications of optical neuroimaging to human factors and usability research. We focus specifically on functional near-infrared spectroscopy (fNIRS) because of its cost-effectiveness and ease of implementation. Researchers have used fNIRS to assess a range of psychological phenomena relevant to human factors, such as cognitive workload, attention, motor activity, and more. It offers the opportunity to measure hemodynamic correlates of mental activity during task completion in human factors and usability studies. We also consider some limitations and future research directions. PMID:28286404

New directions in qualitative research in psychology.

PubMed

Demuth, Carolin

2015-06-01

Qualitative Research gains increasing popularity in the field of Psychology. With the renewed interest, there are, however, also some risks related to the overhomogenization and increasing standardization of qualitative methods. This special issue is dedicated to clarify some of the existing misconceptions of qualitative research and to discuss its potentials for the field of psychology in light of recent endeavors to overcome paradigmatic battles and a re-orientation to the specifities of psychology. The issue comprises a discussion from workshop on the future of qualitative research in psychology organized at Aalborg University, and several contributions that resulted from it.

Space Station Engineering and Technology Development. Proceedings of the Panel on Solar Thermodynamics Research and Technology Development, July 31, 1985

NASA Technical Reports Server (NTRS)

1985-01-01

Solar thermodynamics research and technology is reported. Comments on current program activity and future plans with regard to satisfying potential space station electric power generation requirements are provided. The proceedings contain a brief synopsis of the presentations to the panel, including panel comments, and a summary of the panel's observations. Selected presentation material is appended. Onboard maintainability and repair in space research and technology plan, solar thermodynamic research, program performance, onboard U.S. ground based mission control, and technology development rad maps from 10 C to the growth station are addressed.

A summary of the vocabulary research with students who are deaf or hard of hearing.

PubMed

Luckner, John L; Cooke, Christine

2010-01-01

Vocabulary is essential for communicating, reading, thinking, and learning. In comparison to typical hearing peers, students who are deaf or hard of hearing demonstrate vocabulary knowledge that is quantitatively reduced. The authors review and summarize research studies published in peer-reviewed journals between 1967 and 2008 focusing on vocabulary and students who are deaf or hard of hearing. Forty-one studies are examined. A summary of each study is presented in a table, and potential educational implications are described. The authors note the paucity of research to guide instruction and provide suggestions for future research.

Applications of ICA and fractal dimension in sEMG signal processing for subtle movement analysis: a review.

PubMed

Naik, Ganesh R; Arjunan, Sridhar; Kumar, Dinesh

2011-06-01

The surface electromyography (sEMG) signal separation and decphompositions has always been an interesting research topic in the field of rehabilitation and medical research. Subtle myoelectric control is an advanced technique concerned with the detection, processing, classification, and application of myoelectric signals to control human-assisting robots or rehabilitation devices. This paper reviews recent research and development in independent component analysis and Fractal dimensional analysis for sEMG pattern recognition, and presents state-of-the-art achievements in terms of their type, structure, and potential application. Directions for future research are also briefly outlined.

Plan of Action for Real-World Translation of LGBTQ Health and Aging Research.

PubMed

Fredriksen-Goldsen, Karen I; Kim, Hyun-Jun; McKenzie, Glenise L; Krinsky, Lisa; Emlet, Charles A

2017-12-01

Despite accumulating evidence of health disparities, there exists limited translational research to enhance optimal health and aging of lesbian, gay, bisexual, transgender, and queer-identified * (LGBTQ) older adults. Based on the Health Equity Promotion Model that addresses the distinct needs and strengths of LGBTQ older adults, we underscore the important role of collaborations among researchers, practitioners, and communities to build community capacity. Given the rapidly shifting context, we advance principles to guide future work that will enhance translational research and the development of evidence-based practice so that LGBTQ older adults can reach their full health potential.

[The present state and progress of researches on gait recognition].

PubMed

Xue, Zhaojun; Jin, Jingna; Ming, Dong; Wan, Baikun

2008-10-01

Recognition by gait is a new field for the biometric recognition technology. Its aim is to recognize people and detect physiological, pathological and mental characters by their walk style. The use of gait as a biometric for human identification is promising. The technique of gait recognition, as an attractive research area of biomedical information detection, attracts more and more attention. In this paper is introduced a survey of the basic theory, existing gait recognition methods and potential prospects. The latest progress and key factors of research difficulties are analyzed, and future researches are envisaged.

NASA Space Biology Research Associate Program for the 21st Century

NASA Technical Reports Server (NTRS)

Sonnenfeld, Gerald

2000-01-01

The Space Biology Research Associate Program for the 21st Century provided a unique opportunity to train individuals to conduct biological research in hypo- and hyper-gravity, and to conduct ground-based research. This grant was developed to maximize the potential for Space Biology as an emerging discipline and to train a cadre of space biologists. The field of gravitational and space biology is rapidly growing at the future of the field is reflected in the quality and education of its personnel. Our chief objective was to train and develop these scientists rapidly and in a cost effective model.

Small Engine Component Technology (SECT) study. Program report

NASA Technical Reports Server (NTRS)

Almodovar, E.; Exley, T.; Kaehler, H.; Schneider, W.

1986-01-01

The study was conducted to identify high payoff technologies for year 2000 small gas turbine applications and to provide a technology plan for guiding future research and technology efforts. A regenerative cycle turboprop engine was selected for a 19 passenger commuter aircraft application. A series of engines incorporating eight levels of advanced technologies were studied and their impact on aircraft performance was evaluated. The study indicated a potential reduction in fuel burn of 38.3 percent. At $1.00 per gallon fuel price, a potential DOC benefit of 12.5 percent would be achieved. At $2.00 per gallon, the potential DOC benefit would increase to 17.0 percent. Four advanced technologies are recommended and appropriate research and technology programs were established to reach the year 2000 goals.

The EuPA Biobank Initiative: Meeting the future challenges of biobanking in proteomics & systems medicine.

PubMed

Wheelock, Åsa M; Paulson, Linda; Litton, Jan-Eric

2015-09-08

In this News & Reviews Discussion, the recently launched EuPA (European Proteomics Association) Biobank Initiative is introduced in the context of current and future challenges in biobanking. The purpose of the initiative is to provide a forumand knowledge platform for integrating the extensive experiences collected by the EuPA community, and link it to the European and international biobanking communities at large. The specific impact of providing a forum and easy access to this type of information to the EuPA community is the potential of improving the quality of future sample collections and biobanks, the quality of the research produced from these sample collections, as well as the output and productivity from existing biobanks. The underutilization of biobanks has recently been identified as an emerging issue of biobankingworldwide. Measures to improve our ability to locate and access appropriate sample collections for a wide range of research purposes may enhance both the scientific quality and biobank sustainability, thereby contributing to the important task of moving our research beyond basic findings and mere publications, into clinical practice. This manuscript is intended as a Discussion piece, and represents a recollection of the presentation under the “EuPA Initiative” session at HUPO/EuPA 2014 in Madrid. The launch of the EuPA (European Proteomics Association) Biobank Initiative in the context of current and future challenges in biobanking is discussed. The purpose of the initiative is to provide a forum and knowledge base for integrating the extensive experiences collected by the EuPA community, and link it to the European and international biobanking communities at large. The specific impact of providing a forumand easy access to this type of information to the EuPA community is the potential of improving the quality of future sample collections and biobanks, the quality of the research produced from these sample collections, aswell as the output and productivity fromexisting biobanks. The underutilization of biobanks has recently been identified as a challenge to the well-being and economic sustainability of biobanking worldwide. Measures to improve our ability to localize and access appropriate sample collections for validation studies and other research purposes is thus of benefit bothto scientific quality and biobank sustainability, thereby contributing to the important task of moving our research beyond basic findings and mere publications, into clinical practice. This article is part of a Special Issue entitled: HUPO 2014.

Future Scenarios as a Research Tool: Investigating Climate Change Impacts, Adaptation Options and Outcomes for the Great Barrier Reef, Australia.

PubMed

Evans, Louisa S; Hicks, Christina C; Fidelman, Pedro; Tobin, Renae C; Perry, Allison L

2013-01-01

Climate change is a significant future driver of change in coastal social-ecological systems. Our knowledge of impacts, adaptation options, and possible outcomes for marine environments and coastal industries is expanding, but remains limited and uncertain. Alternative scenarios are a way to explore potential futures under a range of conditions. We developed four alternative future scenarios for the Great Barrier Reef and its fishing and tourism industries positing moderate and more extreme (2-3 °C above pre-industrial temperatures) warming for 2050 and contrasting 'limited' and 'ideal' ecological and social adaptation. We presented these scenarios to representatives of key stakeholder groups to assess the perceived viability of different social adaptation options to deliver desirable outcomes under varied contexts.

The futures of climate engineering

NASA Astrophysics Data System (ADS)

Low, Sean

2017-01-01

This piece examines the need to interrogate the role of the conceptions of the future, as embedded in academic papers, policy documents, climate models, and other artifacts that serve as currencies of the science-society interface, in shaping scientific and policy agendas in climate engineering. Growing bodies of work on framings, metaphors, and models in the past decade serve as valuable starting points, but can benefit from integration with science and technology studies work on the sociology of expectations, imaginaries, and visions. Potentially valuable branches of work to come might be the anticipatory use of the future: the design of experimental spaces for exploring the future of an engineered climate in service of responsible research and innovation, and the integration of this work within the unfolding context of the Paris Agreement.

The carnivorous syndrome in Nepenthes pitcher plants: current state of knowledge and potential future directions.

PubMed

Moran, Jonathan A; Clarke, Charles M

2010-06-01

Nepenthes is the largest genus of pitcher plants, with its centre of diversity in SE Asia. The plants grow in substrates that are deficient in N and offset this deficiency by trapping animal prey, primarily arthropods. Recent research has provided new insights into the function of the pitchers, particularly with regard to prey tapping and retention. Species examined to date use combinations of wettable peristomes, wax layers and viscoelastic fluid to trap and retain prey. In many respects, this has redefined our understanding of the functioning of Nepenthes pitchers. In addition, recent research has shown that several Nepenthes species target specific groups of prey animals, or are even evolving away from a strictly carnivorous mode of operation. Future research into nutrient sequestration strategies and mechanisms of prey attraction would no doubt further enhance our knowledge of the ecology of this remarkable genus.

Materials Science Experiments Under Microgravity - A Review of History, Facilities, and Future Opportunities

NASA Technical Reports Server (NTRS)

Stenzel, Ch.

2012-01-01

Materials science experiments have been a key issue already since the early days of research under microgravity conditions. A microgravity environment facilitates processing of metallic and semiconductor melts without buoyancy driven convection and sedimentation. Hence, crystal growth of semiconductors, solidification of metallic alloys, and the measurement of thermo-physical parameters are the major applications in the field of materials science making use of these dedicated conditions in space. In the last three decades a large number of successful experiments have been performed, mainly in international collaborations. In parallel, the development of high-performance research facilities and the technological upgrade of diagnostic and stimuli elements have also contributed to providing optimum conditions to perform such experiments. A review of the history of materials science experiments in space focussing on the development of research facilities is given. Furthermore, current opportunities to perform such experiments onboard ISS are described and potential future options are outlined.

Recent Progress of Microfluidics in Translational Applications

PubMed Central

Liu, Zongbin; Han, Xin

2016-01-01

Microfluidics, featuring microfabricated structures, is a technology for manipulating fluids at the micrometer scale. The small dimension and flexibility of microfluidic systems are ideal for mimicking molecular and cellular microenvironment, and show great potential in translational research and development. Here, the recent progress of microfluidics in biological and biomedical applications, including molecular analysis, cellular analysis, and chip-based material delivery and biomimetic design is presented. The potential future developments in the translational microfluidics field are also discussed. PMID:27091777

Global-local methodologies and their application to nonlinear analysis. [for structural postbuckling study

NASA Technical Reports Server (NTRS)

Noor, Ahmed K.

1986-01-01

An assessment is made of the potential of different global-local analysis strategies for predicting the nonlinear and postbuckling responses of structures. Two postbuckling problems of composite panels are used as benchmarks and the application of different global-local methodologies to these benchmarks is outlined. The key elements of each of the global-local strategies are discussed and future research areas needed to realize the full potential of global-local methodologies are identified.

Metabolomics and malaria biology

PubMed Central

Lakshmanan, Viswanathan; Rhee, Kyu Y.; Daily, Johanna P.

2010-01-01

Metabolomics has ushered in a novel and multi-disciplinary realm in biological research. It has provided researchers with a platform to combine powerful biochemical, statistical, computational, and bioinformatics techniques to delve into the mysteries of biology and disease. The application of metabolomics to study malaria parasites represents a major advance in our approach towards gaining a more comprehensive perspective on parasite biology and disease etiology. This review attempts to highlight some of the important aspects of the field of metabolomics, and its ongoing and potential future applications to malaria research. PMID:20970461

Quasicrystal structure and growth models: discussion of the status quo and the still open questions

NASA Astrophysics Data System (ADS)

Steurer, Walter

2017-02-01

Where are we now in quasicrystal (QC) research more than three decades after Dan Shechtman’s discovery? Do we fully understand the origin of quasiperiodicity, the formation, growth, thermodynamic stability, structure and properties of quasicrystals? First, I will shortly present the status quo, then I will address the still open questions, and identify potential focus areas for future research. Because of the limited space, I will focus on decagonal quasicrystals (DQCs); the status quo for research on icosahedral quasicrystals (IQCs) is comparable.

Improving collaboration between Primary Care Research Networks using Access Grid technology.

PubMed

Nagykaldi, Zsolt; Fox, Chester; Gallo, Steve; Stone, Joseph; Fontaine, Patricia; Peterson, Kevin; Arvanitis, Theodoros

2008-01-01

Access Grid (AG) is an Internet2-driven, high performance audio-visual conferencing technology used worldwide by academic and government organisations to enhance communication, human interaction and group collaboration. AG technology is particularly promising for improving academic multi-centre research collaborations. This manuscript describes how the AG technology was utilised by the electronic Primary Care Research Network (ePCRN) that is part of the National Institutes of Health (NIH) Roadmap initiative to improve primary care research and collaboration among practice-based research networks (PBRNs) in the USA. It discusses the design, installation and use of AG implementations, potential future applications, barriers to adoption, and suggested solutions.

Association of learning styles with research self-efficacy: study of short-term research training program for medical students.

PubMed

Dumbauld, Jill; Black, Michelle; Depp, Colin A; Daly, Rebecca; Curran, Maureen A; Winegarden, Babbi; Jeste, Dilip V

2014-12-01

With a growing need for developing future physician scientists, identifying characteristics of medical students who are likely to benefit from research training programs is important. This study assessed if specific learning styles of medical students, participating in federally funded short-term research training programs, were associated with research self-efficacy, a potential predictor of research career success. Seventy-five first-year medical students from 28 medical schools, selected to participate in two competitive NIH-supported summer programs for research training in aging, completed rating scales to evaluate learning styles at baseline, and research self-efficacy before and after training. We examined associations of individual learning styles (visual-verbal, sequential-global, sensing-intuitive, and active-reflective) with students' gender, ranking of medical school, and research self-efficacy. Research self-efficacy improved significantly following the training programs. Students with a verbal learning style reported significantly greater research self-efficacy at baseline, while visual, sequential, and intuitive learners demonstrated significantly greater increases in research self-efficacy from baseline to posttraining. No significant relationships were found between learning styles and students' gender or ranking of their medical school. Assessments of learning styles may provide useful information to guide future training endeavors aimed at developing the next generation of physician-scientists. © 2014 Wiley Periodicals, Inc.

Research progress on distribution, migration, transformation of antibiotics and antibiotic resistance genes (ARGs) in aquatic environment.

PubMed

Shao, Sicheng; Hu, Yongyou; Cheng, Jianhua; Chen, Yuancai

2018-05-28

Antimicrobial and antibiotics resistance caused by misuse or overuse of antibiotics exposure is a growing and significant threat to global public health. The spread and horizontal transfer of antibiotic resistant bacteria (ARB) and antibiotic resistance genes (ARGs) by the selective pressure of antibiotics in an aquatic environment is a major public health issue. To develop a better understanding of potential ecological risks die to antibiotics and ARGs, this study mainly summarizes research progress about: (i) the occurrence, concentration, fate, and potential ecological effects of antibiotics and ARGs in various aquatic environments, (ii) the threat, spread, and horizontal gene transfer (HGT) of ARGs, and (iii) the relationship between antibiotics, ARGs, and ARB. Finally, this review also proposes future research direction on antibiotics and ARGs.

Nonlinear Optics with 2D Layered Materials.

PubMed

Autere, Anton; Jussila, Henri; Dai, Yunyun; Wang, Yadong; Lipsanen, Harri; Sun, Zhipei

2018-06-01

2D layered materials (2DLMs) are a subject of intense research for a wide variety of applications (e.g., electronics, photonics, and optoelectronics) due to their unique physical properties. Most recently, increasing research efforts on 2DLMs are projected toward the nonlinear optical properties of 2DLMs, which are not only fascinating from the fundamental science point of view but also intriguing for various potential applications. Here, the current state of the art in the field of nonlinear optics based on 2DLMs and their hybrid structures (e.g., mixed-dimensional heterostructures, plasmonic structures, and silicon/fiber integrated structures) is reviewed. Several potential perspectives and possible future research directions of these promising nanomaterials for nonlinear optics are also presented. © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Induced pluripotent stem cells--alchemist's tale or clinical reality?

PubMed

Rashid, S Tamir; Vallier, Ludovic

2010-08-13

Following Shinya Yamanaka's first report describing the reprogramming of fibroblasts into stem cells over three years ago, some sceptics initially drew analogies between this new field of research and the quasi-mystical practice of 'alchemy'. Unlike the alchemist, however, stem cell researchers have rigorously tested and repeated experiments, proving their very own brand of cellular 'alchemy' to be a reality, with potentially massive implications for the study of human biology and clinical medicine. These investigations have resulted in an explosion of related publications and initiated the field of stem cell research known as 'induced pluripotency'. In this review, we give an account of the historical development, current technologies and potential clinical applications of induced pluripotency and conclude with a perspective on the possible future directions for this dynamic field.

Directions for social research to underpin improved groundwater management

NASA Astrophysics Data System (ADS)

Mitchell, Michael; Curtis, Allan; Sharp, Emily; Mendham, Emily

2012-07-01

SummaryImprovements in groundwater management require strategies to change human behaviour, yet there has been limited social research in the broad arena of groundwater management. This paper provides a critical review of the small but expanding literature on that topic to identify future directions for social researchers. Comprehensive search methods identified almost three hundred potentially relevant publications, which were sorted thematically and assessed in terms of their theoretical underpinning and the evidence used to support key findings. This process enabled the authors to identify a small number of high quality publications and to identify future research opportunities. The latter includes analysing how concepts of risk and sustainable yield are constructed differently by stakeholders, especially related to divisive issues concerning coal seam gas developments and reforms that reduce irrigation allocations; how governance arrangements can be improved to achieve more effective collaborative management of groundwater, especially if managed aquifer recharge is to be more widely implemented in rural agricultural contexts; and the role that trust and social norms can play in changing groundwater use practices.

Killer Apps: Developing Novel Applications That Enhance Team Coordination, Communication, and Effectiveness

PubMed Central

Buengeler, Claudia; Klonek, Florian; Lehmann-Willenbrock, Nale; Morency, Louis-Philippe; Poppe, Ronald

2017-01-01

As part of the Lorentz workshop, “Interdisciplinary Insights into Group and Team Dynamics,” held in Leiden, Netherlands, this article describes how Geeks and Groupies (computer and social scientists) may benefit from interdisciplinary collaboration toward the development of killer apps in team contexts that are meaningful and challenging for both. First, we discuss interaction processes during team meetings as a research topic for both Groupies and Geeks. Second, we highlight teamwork in health care settings as an interdisciplinary research challenge. Third, we discuss how an automated solution for optimal team design could benefit team effectiveness and feed into team-based interventions. Fourth, we discuss team collaboration in massive open online courses as a challenge for both Geeks and Groupies. We argue for the necessary integration of social and computational research insights and approaches. In the hope of inspiring future interdisciplinary collaborations, we develop criteria for evaluating killer apps—including the four proposed here—and discuss future research challenges and opportunities that potentially derive from these developments. PMID:28989264

Future Directions for Examination of Brain Networks in Neurodevelopmental Disorders.

PubMed

Uddin, Lucina Q; Karlsgodt, Katherine H

2018-01-01

Neurodevelopmental disorders are associated with atypical development and maturation of brain networks. A recent focus on human connectomics research and the growing popularity of open science initiatives has created the ideal climate in which to make real progress toward understanding the neurobiology of disorders affecting youth. Here we outline future directions for neuroscience researchers examining brain networks in neurodevelopmental disorders, highlighting gaps in the current literature. We emphasize the importance of leveraging large neuroimaging and phenotypic data sets recently made available to the research community, and we suggest specific novel methodological approaches, including analysis of brain dynamics and structural connectivity, that have the potential to produce the greatest clinical insight. Transdiagnostic approaches will also become increasingly necessary as the Research Domain Criteria framework put forth by the National Institute of Mental Health permeates scientific discourse. During this exciting era of big data and increased computational sophistication of analytic tools, the possibilities for significant advancement in understanding neurodevelopmental disorders are limitless.

Killer Apps: Developing Novel Applications That Enhance Team Coordination, Communication, and Effectiveness.

PubMed

Buengeler, Claudia; Klonek, Florian; Lehmann-Willenbrock, Nale; Morency, Louis-Philippe; Poppe, Ronald

2017-10-01

As part of the Lorentz workshop, "Interdisciplinary Insights into Group and Team Dynamics," held in Leiden, Netherlands, this article describes how Geeks and Groupies (computer and social scientists) may benefit from interdisciplinary collaboration toward the development of killer apps in team contexts that are meaningful and challenging for both. First, we discuss interaction processes during team meetings as a research topic for both Groupies and Geeks. Second, we highlight teamwork in health care settings as an interdisciplinary research challenge. Third, we discuss how an automated solution for optimal team design could benefit team effectiveness and feed into team-based interventions. Fourth, we discuss team collaboration in massive open online courses as a challenge for both Geeks and Groupies. We argue for the necessary integration of social and computational research insights and approaches. In the hope of inspiring future interdisciplinary collaborations, we develop criteria for evaluating killer apps-including the four proposed here-and discuss future research challenges and opportunities that potentially derive from these developments.

Development and applications of single particle orientation and rotational tracking in dynamic systems

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chen, Kuangcai

The goal of this study is to help with future data analysis and experiment designs in rotational dynamics research using DIC-based SPORT technique. Most of the current studies using DIC-based SPORT techniques are technical demonstrations. Understanding the mechanisms behind the observed rotational behaviors of the imaging probes should be the focus of the future SPORT studies. More efforts are still needed in the development of new imaging probes, particle tracking methods, instrumentations, and advanced data analysis methods to further extend the potential of DIC-based SPORT technique.

Origin and Future of Plasmonic Optical Tweezers

PubMed Central

Huang, Jer-Shing; Yang, Ya-Tang

2015-01-01

Plasmonic optical tweezers can overcome the diffraction limits of conventional optical tweezers and enable the trapping of nanoscale objects. Extension of the trapping and manipulation of nanoscale objects with nanometer position precision opens up unprecedented opportunities for applications in the fields of biology, chemistry and statistical and atomic physics. Potential applications include direct molecular manipulation, lab-on-a-chip applications for viruses and vesicles and the study of nanoscale transport. This paper reviews the recent research progress and development bottlenecks and provides an overview of possible future directions in this field. PMID:28347051

Origin and Future of Plasmonic Optical Tweezers.

PubMed

Huang, Jer-Shing; Yang, Ya-Tang

2015-06-12

Plasmonic optical tweezers can overcome the diffraction limits of conventional optical tweezers and enable the trapping of nanoscale objects. Extension of the trapping and manipulation of nanoscale objects with nanometer position precision opens up unprecedented opportunities for applications in the fields of biology, chemistry and statistical and atomic physics. Potential applications include direct molecular manipulation, lab-on-a-chip applications for viruses and vesicles and the study of nanoscale transport. This paper reviews the recent research progress and development bottlenecks and provides an overview of possible future directions in this field.

Advanced Learning Technologies and Learning Networks and Their Impact on Future Aerospace Workforce

NASA Technical Reports Server (NTRS)

Noor, Ahmed K. (Compiler)

2003-01-01

This document contains the proceedings of the training workshop on Advanced Learning Technologies and Learning Networks and their impact on Future Aerospace Workforce. The workshop was held at the Peninsula Workforce Development Center, Hampton, Virginia, April 2 3, 2003. The workshop was jointly sponsored by Old Dominion University and NASA. Workshop attendees came from NASA, other government agencies, industry, and universities. The objectives of the workshop were to: 1) provide broad overviews of the diverse activities related to advanced learning technologies and learning environments, and 2) identify future directions for research that have high potential for aerospace workforce development. Eighteen half-hour overviewtype presentations were made at the workshop.

Evaluation of Human and AutomationRobotics Integration Needs for Future Human Exploration Missions

NASA Technical Reports Server (NTRS)

Marquez, Jessica J.; Adelstein, Bernard D.; Ellis, Stephen; Chang, Mai Lee; Howard, Robert

2016-01-01

NASA employs Design Reference Missions (DRMs) to define potential architectures for future human exploration missions to deep space, the Moon, and Mars. While DRMs to these destinations share some components, each mission has different needs. This paper focuses on the human and automation/robotic integration needs for these future missions, evaluating them with respect to NASA research gaps in the area of space human factors engineering. The outcomes of our assessment is a human and automation/robotic (HAR) task list for each of the four DRMs that we reviewed (i.e., Deep Space Sortie, Lunar Visit/Habitation, Deep Space Habitation, and Planetary), a list of common critical HAR factors that drive HAR design.

Assessing surgical research at the teaching hospital level.

PubMed

McBride, Kate E; Young, Jane M; Bannon, Paul G; Solomon, Michael J

2017-01-01

To undertake a comprehensive needs assessment to determine the baseline of surgical research activity at a tertiary referral hospital in Sydney, Australia. The comprehensive needs assessment comprised three components: a retrospective audit of the hospital ethics committee records to identify surgical research activity; a survey of all 17 surgical departments about the availability of 10 potential research resources and a survey of surgical staff to ascertain perceptions of research culture at the organizational, team and individual levels. Of all research studies submitted to the hospital ethics committee in a 2-year period, only 9% were identified as surgical studies. Among the 17 surgical departments, there was wide variation in activity with only four defined as being 'research active'. On average, 52% of potential resources for surgical research were found to be in place within surgical departments. Only five departments were considered to be adequately research resourced (≥75% potential resources in place). Surgical research culture was rated 'moderate' at the organizational and team level, and 'low' at the individual level. Medical staff rated research capacity significantly higher at the team and individual levels compared to nursing staff. Collectively, the baseline results indicate there is considerable opportunity to enhance surgical research at the hospital level and to use this information to guide new and innovative approaches in the future. © 2016 Royal Australasian College of Surgeons.

Formative research to identify perceptions of e-cigarettes in college students: Implications for future health communication campaigns

PubMed Central

Case, Kathleen; Crook, Brittani; Lazard, Allison; Mackert, Michael

2016-01-01

Objective This formative study examined perceptions of e-cigarettes in college students with the goal of informing future health communication campaigns. Differences between e-cigarette users and nonusers were also examined. Participants: Thirty undergraduate students were recruited from a large southwestern public university (15 users, 15 nonusers). Methods Structured interviews were conducted and transcripts were coded for themes. Results Although users had more favorable attitudes toward e-cigarettes, both users and nonusers believed that e-cigarettes produce water vapor and reported that e-cigarettes were less harmful than conventional cigarettes. Potential health consequences and addiction concerns were the most common perceived threats for both users and nonusers. Both nonusers and users cited social stigma as a perceived disadvantage of e-cigarette use. Conclusions Ultimately, themes with particular relevance to future health communication campaigns included negative perceptions of e-cigarette users and social stigma, as well as harm perceptions and potential health consequences associated with e-cigarette use. PMID:26979833

Formative research to identify perceptions of e-cigarettes in college students: Implications for future health communication campaigns.

PubMed

Case, Kathleen; Crook, Brittani; Lazard, Allison; Mackert, Michael

2016-07-01

This formative study examined perceptions of e-cigarettes in college students with the goal of informing future health communication campaigns. Differences between e-cigarette users and nonusers were also examined. Thirty undergraduate students were recruited from a large southwestern public university (15 users, 15 nonusers). Structured interviews were conducted and transcripts were coded for themes. Although users had more favorable attitudes toward e-cigarettes, both users and nonusers believed that e-cigarettes produce water vapor and reported that e-cigarettes were less harmful than conventional cigarettes. Potential health consequences and addiction concerns were the most common perceived threats for both users and nonusers. Both nonusers and users cited social stigma as a perceived disadvantage of e-cigarette use. Ultimately, themes with particular relevance to future health communication campaigns included negative perceptions of e-cigarette users and social stigma, as well as harm perceptions and potential health consequences associated with e-cigarette use.

Sociotechnical approaches to workplace safety: Research needs and opportunities.

PubMed

Robertson, Michelle M; Hettinger, Lawrence J; Waterson, Patrick E; Noy, Y Ian; Dainoff, Marvin J; Leveson, Nancy G; Carayon, Pascale; Courtney, Theodore K

2015-01-01

The sociotechnical systems perspective offers intriguing and potentially valuable insights into problems associated with workplace safety. While formal sociotechnical systems thinking originated in the 1950s, its application to the analysis and design of sustainable, safe working environments has not been fully developed. To that end, a Hopkinton Conference was organised to review and summarise the state of knowledge in the area and to identify research priorities. A group of 26 international experts produced collaborative articles for this special issue of Ergonomics, and each focused on examining a key conceptual, methodological and/or theoretical issue associated with sociotechnical systems and safety. In this concluding paper, we describe the major conference themes and recommendations. These are organised into six topic areas: (1) Concepts, definitions and frameworks, (2) defining research methodologies, (3) modelling and simulation, (4) communications and decision-making, (5) sociotechnical attributes of safe and unsafe systems and (6) potential future research directions for sociotechnical systems research. Sociotechnical complexity, a characteristic of many contemporary work environments, presents potential safety risks that traditional approaches to workplace safety may not adequately address. In this paper, we summarise the investigations of a group of international researchers into questions associated with the application of sociotechnical systems thinking to improve worker safety.

The Many Faces of Patient-Centered Simulation: Implications for Researchers.

PubMed

Arnold, Jennifer L; McKenzie, Frederic Rick D; Miller, Jane Lindsay; Mancini, Mary E

2018-06-01

Patient-centered simulation for nonhealthcare providers is an emerging and innovative application for healthcare simulation. Currently, no consensus exists on what patient-centered simulation encompasses and outcomes research in this area is limited. Conceptually, patient-centered simulation aligns with the principles of patient- and family-centered care bringing this educational tool directly to patients and caregivers with the potential to improve patient care and outcomes. This descriptive article is a summary of findings presented at the 2nd International Meeting for Simulation in Healthcare Research Summit. Experts in the field delineated a categorization for better describing patient-centered simulation and reviewed the literature to identify a research agenda. Three types of patient-centered simulation patient-directed, patient-driven, and patient-specific are presented with research priorities identified for each. Patient-centered simulation has been shown to be an effective educational tool and has the potential to directly improve patient care outcomes. Presenting a typology for patient-centered simulation provides direction for future research.

Impact of HIPAA on Subject Recruitment and Retention

PubMed Central

Wipke-Tevis, Deidre D.; Pickett, Melissa A.

2009-01-01

Recruiting and retaining an adequate sample of subjects is critical to the success of any research project involving human subjects. Recent reports indicate the Health Insurance Portability and Accountability Act (HIPAA) Privacy rule has adversely impacted research. Few resources are available to help researchers and their staff navigate the challenges to subject recruitment and retention after the implementation of the HIPAA Privacy rule. This article will address obstacles to subject recruitment in prospective, clinical research studies related specifically to the HIPAA Privacy rule as well as HIPAA compliant strategies to enhance subject recruitment and retention. Recruitment challenges discussed include evolving interpretations of the HIPAA regulations, inability to directly contact potential subjects, complexity of the HIPAA required documents, the increased cost of subject recruitment, and an expanding administrative burden. Among the strategies addressed are preparatory research reviews, use of clinical collaborators/staff liaisons, pre-screening of potential subjects, minimizing subject burden during the consent process, enhancing follow-up of subjects, facilitating recruitment for future studies and streamlining compliance training for research staff. PMID:17551087

The use of qualitative methods to inform Delphi surveys in core outcome set development.

PubMed

Keeley, T; Williamson, P; Callery, P; Jones, L L; Mathers, J; Jones, J; Young, B; Calvert, M

2016-05-04

Core outcome sets (COS) help to minimise bias in trials and facilitate evidence synthesis. Delphi surveys are increasingly being used as part of a wider process to reach consensus about what outcomes should be included in a COS. Qualitative research can be used to inform the development of Delphi surveys. This is an advance in the field of COS development and one which is potentially valuable; however, little guidance exists for COS developers on how best to use qualitative methods and what the challenges are. This paper aims to provide early guidance on the potential role and contribution of qualitative research in this area. We hope the ideas we present will be challenged, critiqued and built upon by others exploring the role of qualitative research in COS development. This paper draws upon the experiences of using qualitative methods in the pre-Delphi stage of the development of three different COS. Using these studies as examples, we identify some of the ways that qualitative research might contribute to COS development, the challenges in using such methods and areas where future research is required. Qualitative research can help to identify what outcomes are important to stakeholders; facilitate understanding of why some outcomes may be more important than others, determine the scope of outcomes; identify appropriate language for use in the Delphi survey and inform comparisons between stakeholder data and other sources, such as systematic reviews. Developers need to consider a number of methodological points when using qualitative research: specifically, which stakeholders to involve, how to sample participants, which data collection methods are most appropriate, how to consider outcomes with stakeholders and how to analyse these data. A number of areas for future research are identified. Qualitative research has the potential to increase the research community's confidence in COS, although this will be dependent upon using rigorous and appropriate methodology. We have begun to identify some issues for COS developers to consider in using qualitative methods to inform the development of Delphi surveys in this article.