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Sample records for g matrix

  1. Environmental effects on the structure of the G-matrix.

    PubMed

    Wood, Corlett W; Brodie, Edmund D

    2015-11-01

    Genetic correlations between traits determine the multivariate response to selection in the short term, and thereby play a causal role in evolutionary change. Although individual studies have documented environmentally induced changes in genetic correlations, the nature and extent of environmental effects on multivariate genetic architecture across species and environments remain largely uncharacterized. We reviewed the literature for estimates of the genetic variance-covariance (G) matrix in multiple environments, and compared differences in G between environments to the divergence in G between conspecific populations (measured in a common garden). We found that the predicted evolutionary trajectory differed as strongly between environments as it did between populations. Between-environment differences in the underlying structure of G (total genetic variance and the relative magnitude and orientation of genetic correlations) were equal to or greater than between-population differences. Neither environmental novelty, nor the difference in mean phenotype predicted these differences in G. Our results suggest that environmental effects on multivariate genetic architecture may be comparable to the divergence that accumulates over dozens or hundreds of generations between populations. We outline avenues of future research to address the limitations of existing data and characterize the extent to which lability in genetic correlations shapes evolution in changing environments.

  2. G. Einstein matrix and nano-biophotonic treatment

    NASA Astrophysics Data System (ADS)

    Przybyl-Einstein, George; Moratin, Holdy; Garcia, Eduardo

    2005-04-01

    The publication is presenting the Einstein Matrix Treatment Method and initial results for blood borne diseases on example of hepatitis, HIV and arthritis. The initial research was conducted at Einstein Clinical Laboratories S.A. on limited funds. The treatment and method is strongly recommended for specific viruses bacteria in blood borne diseases but also for treatment of none specific viruses and bacteria in emergency treatments as SARS or ANTHRAX to safe life of the human. In the past years the Individual's Safety is in jeopardy by natural viral infections as well as by engineering cultured viruses and bacteria. Viruses mutate and become more resistant to current known medical treatment, in many cases partially efficient. This event required new testing method to investigate the possibility of treatments and to create new vaccine for non-specific viral and bacteria or viruses infections that causes death to thousands adults and children. The authors present in this paper the possibility of treatment of the non-specific viral, bacterial infections of the blood in human body. This treatment has safe procedure and no known side effect up to this time for patients that were treated at Einstein Clinical Laboratories SA.

  3. PslG, a self-produced glycosyl hydrolase, triggers biofilm disassembly by disrupting exopolysaccharide matrix

    PubMed Central

    Yu, Shan; Su, Tiantian; Wu, Huijun; Liu, Shiheng; Wang, Di; Zhao, Tianhu; Jin, Zengjun; Du, Wenbin; Zhu, Mei-Jun; Chua, Song Lin; Yang, Liang; Zhu, Deyu; Gu, Lichuan; Ma, Luyan Z

    2015-01-01

    Biofilms are surface-associated communities of microorganism embedded in extracellular matrix. Exopolysaccharide is a critical component in the extracellular matrix that maintains biofilm architecture and protects resident biofilm bacteria from antimicrobials and host immune attack. However, self-produced factors that target the matrix exopolysaccharides, are still poorly understood. Here, we show that PslG, a protein involved in the synthesis of a key biofilm matrix exopolysaccharide Psl in Pseudomonas aeruginosa, prevents biofilm formation and disassembles existing biofilms within minutes at nanomolar concentrations when supplied exogenously. The crystal structure of PslG indicates the typical features of an endoglycosidase. PslG mainly disrupts the Psl matrix to disperse bacteria from biofilms. PslG treatment markedly enhances biofilm sensitivity to antibiotics and macrophage cells, resulting in improved biofilm clearance in a mouse implant infection model. Furthermore, PslG shows biofilm inhibition and disassembly activity against a wide range of Pseudomonas species, indicating its great potential in combating biofilm-related complications. PMID:26611635

  4. Population differentiation in G matrix structure due to natural selection in Rana temporaria.

    PubMed

    Cano, José Manuel; Laurila, Anssi; Pało, Jukka; Merilä, Juha

    2004-09-01

    The additive genetic variance-covariance matrix (G) is a concept central to discussions about evolutionary change over time in a suite of traits. However, at the moment we do not know how fast G itself changes as a consequence of selection or how sensitive it is to environmental influences. We investigated possible evolutionary divergence and environmental influences on G using data from a factorial common-garden experiment where common frog (Rana temporaria) tadpoles from two divergent populations were exposed to three different environmental treatments. G-matrices were estimated using an animal model approach applied to data from a NCII breeding design. Matrix comparisons using both Flury and multivariate analysis of variance methods revealed significant differences in G matrices both between populations and between treatments within populations, the former being generally larger than the latter. Comparison of levels of population differentiation in trait means using Q(ST) indices with that observed in microsatellite markers (F(ST)) revealed that the former values generally exceeded the neutral expectation set by F(ST). Hence, the results suggest that intraspecific divergence in G matrix structure has occurred mainly due to natural selection.

  5. Cauchy-Laguerre Two-Matrix Model and the Meijer-G Random Point Field

    NASA Astrophysics Data System (ADS)

    Bertola, M.; Gekhtman, M.; Szmigielski, J.

    2014-02-01

    We apply the general theory of Cauchy biorthogonal polynomials developed in Bertola et al. (Commun Math Phys 287(3):983-1014, 2009) and Bertola et al. (J Approx Th 162(4):832-867, 2010) to the case associated with Laguerre measures. In particular, we obtain explicit formulae in terms of Meijer-G functions for all key objects relevant to the study of the corresponding biorthogonal polynomials and the Cauchy two-matrix model associated with them. The central theorem we prove is that a scaling limit of the correlation functions for eigenvalues near the origin exists, and is given by a new determinantal two-level random point field, the Meijer-G random field. We conjecture that this random point field leads to a novel universality class of random fields parametrized by exponents of Laguerre weights. We express the joint distributions of the smallest eigenvalues in terms of suitable Fredholm determinants and evaluate them numerically. We also show that in a suitable limit, the Meijer-G random field converges to the Bessel random field and hence the behavior of the eigenvalues of one of the two matrices converges to the one of the Laguerre ensemble.

  6. Gmat. A software tool for the computation of the rovibrational G matrix

    NASA Astrophysics Data System (ADS)

    Castro, M. E.; Niño, A.; Muñoz-Caro, C.

    2009-07-01

    Gmat is a C++ program able to compute the rovibrational G matrix in molecules of arbitrary size. This allows the building of arbitrary rovibrational Hamiltonians. In particular, the program is designed to work with the structural results of potential energy hypersurface mappings computed in computer clusters or computational Grid environments. In the present version, 1.0, the program uses internal coordinates as vibrational coordinates, with the principal axes of inertia as body-fixed system. The main design implements a complete separation of the interface and functional parts of the program. The interface part permits the automatic reading of the molecular structures from the output files of different electronic structure codes. At present, Gamess and Gaussian output files are allowed. To such an end, use is made of the object orientation polymorphism characteristic. The functional part computes numerically the derivatives of the nuclear positions respect to the vibrational coordinates. Very accurate derivatives are obtained by using central differences embedded in a nine levels Richardson extrapolation procedure. Program summaryProgram title: Gmat Catalogue identifier: AECZ_v1_0 Program summary URL:http://cpc.cs.qub.ac.uk/summaries/AECZ_v1_0.html Program obtainable from: CPC Program Library, Queen's University, Belfast, N. Ireland Licensing provisions: Standard CPC licence, http://cpc.cs.qub.ac.uk/licence/licence.html No. of lines in distributed program, including test data, etc.: 17 023 No. of bytes in distributed program, including test data, etc.: 274 714 Distribution format: tar.gz Programming language: Standard C++ Computer: All running Linux/Windows Operating system: Linux, Windows Classification: 16.2 Nature of problem: Computation of the rovibrational G matrix in molecules of any size. This allows the building of arbitrary rovibrational Hamiltonians. It must be possible to obtain the input data from the output files of standard electronic structure codes

  7. Reaction Rate Uncertainties using R-matrix: 3He(a,g) and 12C(a,g)

    NASA Astrophysics Data System (ADS)

    Deboer, Richard; Goerres, Joachim; Smith, Karl; Uberseder, Ethan; Wiescher, Michael; Imbriani, Gianluca; Kontos, Antonios

    2013-10-01

    Many of the reaction rates involving light nuclei in the pp chains and the CNO cycles are heavily influenced by short lived nuclear states. These states manifest as broad resonance structures observed in the cross sections of low energy reaction data. Because of the Coulomb repulsion between the two charged particles, the low energy cross section is often too small to be measure directly in the laboratory. For this reason, experimental measurements are made at higher energies, and then extrapolated down to the energy region of astrophysical interest. The energy dependence of the experimentally measured cross sections may be described using R-matrix theory. While R-matrix theory has proved to be quite successful, it is often difficult to extract uncertainties from the mathematically complicated framework. To illustrate these points, R-matrix analysis for the reactions 3He(α , γ) 7Be and 12C(α , γ) 16O will be described. A Monte Carlo uncertainty analysis is performed in order to extract statistically meaningful uncertainties. To find the total rate uncertainty, the R-matrix MC analysis can be combined with an MC analysis for the narrow resonance contributions using, for example, the Starlib code RatesMC. This work was funded by the National Science Foundation through Grant No. Phys-0758100, and the Joint Institute for Nuclear Astrophysics through Grant No. Phys-0822648.

  8. Microwave initiated synthesis of polyacrylamide grafted carboxymethylstarch (CMS-g-PAM): application as a novel matrix for sustained drug release.

    PubMed

    Sen, Gautam; Pal, Sagar

    2009-07-01

    This paper reports the investigation of microwave initiated synthesized polyacrylamide grafted carboxymethylstarch (CMS-g-PAM) as matrix for sustained drug release. 'In vitro' release of a model drug (5-amino salicylic acid) from CMS-g-PAM matrix has been studied. It is evident that higher the percentage grafting, more sustained is the rate of drug release. Further, the percentage grafting vs. t(50) value (i.e. time taken for release of 50% of the enclosed drug) correlation has been successfully studied for the first time. This correlation will lead to the possibility of a programmable drug release matrix based on grafted polysaccharide. In this matrix, the rate of release of the enclosed drug can be precisely programmed simply by adjustment of percentage grafting during synthesis.

  9. Spin orbit coupling for molecular ab initio density matrix renormalization group calculations: Application to g-tensors

    SciTech Connect

    Roemelt, Michael

    2015-07-28

    Spin Orbit Coupling (SOC) is introduced to molecular ab initio density matrix renormalization group (DMRG) calculations. In the presented scheme, one first approximates the electronic ground state and a number of excited states of the Born-Oppenheimer (BO) Hamiltonian with the aid of the DMRG algorithm. Owing to the spin-adaptation of the algorithm, the total spin S is a good quantum number for these states. After the non-relativistic DMRG calculation is finished, all magnetic sublevels of the calculated states are constructed explicitly, and the SOC operator is expanded in the resulting basis. To this end, spin orbit coupled energies and wavefunctions are obtained as eigenvalues and eigenfunctions of the full Hamiltonian matrix which is composed of the SOC operator matrix and the BO Hamiltonian matrix. This treatment corresponds to a quasi-degenerate perturbation theory approach and can be regarded as the molecular equivalent to atomic Russell-Saunders coupling. For the evaluation of SOC matrix elements, the full Breit-Pauli SOC Hamiltonian is approximated by the widely used spin-orbit mean field operator. This operator allows for an efficient use of the second quantized triplet replacement operators that are readily generated during the non-relativistic DMRG algorithm, together with the Wigner-Eckart theorem. With a set of spin-orbit coupled wavefunctions at hand, the molecular g-tensors are calculated following the scheme proposed by Gerloch and McMeeking. It interprets the effective molecular g-values as the slope of the energy difference between the lowest Kramers pair with respect to the strength of the applied magnetic field. Test calculations on a chemically relevant Mo complex demonstrate the capabilities of the presented method.

  10. Spin orbit coupling for molecular ab initio density matrix renormalization group calculations: Application to g-tensors

    NASA Astrophysics Data System (ADS)

    Roemelt, Michael

    2015-07-01

    Spin Orbit Coupling (SOC) is introduced to molecular ab initio density matrix renormalization group (DMRG) calculations. In the presented scheme, one first approximates the electronic ground state and a number of excited states of the Born-Oppenheimer (BO) Hamiltonian with the aid of the DMRG algorithm. Owing to the spin-adaptation of the algorithm, the total spin S is a good quantum number for these states. After the non-relativistic DMRG calculation is finished, all magnetic sublevels of the calculated states are constructed explicitly, and the SOC operator is expanded in the resulting basis. To this end, spin orbit coupled energies and wavefunctions are obtained as eigenvalues and eigenfunctions of the full Hamiltonian matrix which is composed of the SOC operator matrix and the BO Hamiltonian matrix. This treatment corresponds to a quasi-degenerate perturbation theory approach and can be regarded as the molecular equivalent to atomic Russell-Saunders coupling. For the evaluation of SOC matrix elements, the full Breit-Pauli SOC Hamiltonian is approximated by the widely used spin-orbit mean field operator. This operator allows for an efficient use of the second quantized triplet replacement operators that are readily generated during the non-relativistic DMRG algorithm, together with the Wigner-Eckart theorem. With a set of spin-orbit coupled wavefunctions at hand, the molecular g-tensors are calculated following the scheme proposed by Gerloch and McMeeking. It interprets the effective molecular g-values as the slope of the energy difference between the lowest Kramers pair with respect to the strength of the applied magnetic field. Test calculations on a chemically relevant Mo complex demonstrate the capabilities of the presented method.

  11. Novel hydrophobic interaction chromatography matrix for specific isolation and simple elution of immunoglobulins (A, G, and M) from porcine serum.

    PubMed

    Ramos-Clamont, Gabriela; del Carmen Candia-Plata, Maria; Zamudio, Roberto Guzman; Vazquez-Moreno, Luz

    2006-07-28

    A new, highly acetylated agarose matrix (HA-Sepharose) was synthesized and used as a hydrophobic interaction chromatography (HIC) medium to specifically isolate immunoglobulins (Igs) from porcine serum. Recovery of Igs was in a single step and under mild conditions. HA-Sepharose adsorption was studied in terms of salt, gel acetylation time, flow rate, and protein concentration on the loading buffer. At 0.5 M Na2SO4, control with unmodified Sepharose retained a small fraction (0.70 mg/mL of matrix) of serum albumin. On the contrary HA-Sepharose retained primary Igs (IgA, IgG, and 53% of IgM) as revealed by sodium dodecyl sulphate 10% polyacrylamide gel electrophoresis (SDS-PAGE), quantitative radial immunodiffusion and immunodetection. At a flow rate of 1 mL/min, the HA-Sepharose column capacity (3.9 mg/mL of matrix) was similar to the reported capacity for the commercial thiophilic T-gel. However, HA-Sepharose showed higher recovery of IgA and IgM than the T-gel in the same salt conditions, clearly an advantage in terms of immunoglobulin recovery strategies. Acetylation changed the matrix adsorption from albumin to immunoglobulins; thus, the highly acetylated gel rendered recoveries of Igs from unprocessed porcine serum practically free of albumin.

  12. Matrix metalloproteinase and G protein coupled receptors: co-conspirators in the pathogenesis of autoimmune disease and cancer.

    PubMed

    Eck, Sarah M; Blackburn, Jessica S; Schmucker, Adam C; Burrage, Peter S; Brinckerhoff, Constance E

    2009-01-01

    Similarities in the pathologies of autoimmune diseases and cancer have been noted for at least 30 years. Inflammatory cytokines and growth factors mediate cell proliferation, and proteinases, especially the collagenase, Matrix Metalloproteinase-1 (MMP-1), contribute to disease progression by remodeling the extracellular matrix and modulating the microenvironment. This review focuses on two cancers (melanoma and breast) and on the autoimmune disorder, rheumatoid arthritis (RA), and discusses the activated stromal cells found in these diseases. MMP-1 was originally thought to function only to degrade interstitial collagens, but recent studies have revealed novel roles for MMP-1 involving the G protein-coupled receptors: the chemokine receptor, CXCR-4, and Protease Activated Receptor-1 (PAR-1). Cooperativity between MMP-1 and CXCR4/SDF-1 signaling influences the behavior of activated fibroblasts in both RA and cancer. Further, MMP-1 is a vital part of an autocrine/paracrine MMP-1/PAR-1 signal transduction axis, a function that amplifies its potential to remodel the matrix and to modify cell behavior. Finally, new therapeutic agents directed at MMP-1 and G protein-coupled receptors are emerging. Even though these agents are more specific in their targets than past therapies, these targets are often shared between RA and cancer, underscoring fundamental similarities between autoimmune disorders and some cancers.

  13. Matrix Metalloproteinase and G Protein Coupled Receptors: Co-conspirators in the pathogenesis of autoimmune disease and cancer

    PubMed Central

    Eck, Sarah M.; Blackburn, Jessica S.; Schmucker, Adam C.; Burrage, Peter S.; Brinckerhoff, Constance E.

    2009-01-01

    Similarities in the pathologies of autoimmune diseases and cancer have been noted for at least 30 years. Inflammatory cytokines and growth factors mediate cell proliferation, and proteinases, especially the collagenase, Matrix Metalloproteinase-1 (MMP-1), contribute to disease progression by remodeling the extracellular matrix and modulating the microenvironment. This review focuses on two cancers (melanoma and breast) and on the autoimmune disorder, rheumatoid arthritis (RA), and discusses the activated stromal cells found in these diseases. MMP-1 was originally thought to function only to degrade interstitial collagens, but recent studies have revealed novel roles for MMP-1 involving the G protein-coupled receptors: the chemokine receptor, CXCR-4, and Protease Activated Receptor-1 (PAR-1). Cooperativity between MMP-1 and CXCR4/SDF-1 signaling influences the behavior of activated fibroblasts in both RA and cancer. Further, MMP-1 is a vital part of an autocrine/paracrine MMP-1/PAR-1 signal transduction axis, a function that amplifies its potential to remodel the matrix and to modify cell behavior. Finally, new therapeutic agents directed at MMP-1 and G protein-coupled receptors are emerging. Even though these agents are more specific in their targets than past therapies, these targets are often shared between RA and cancer, underscoring fundamental similarities between autoimmune disorders and some cancers. PMID:19800199

  14. Multivariate QST-FST comparisons: a neutrality test for the evolution of the g matrix in structured populations.

    PubMed

    Martin, Guillaume; Chapuis, Elodie; Goudet, Jérôme

    2008-12-01

    Neutrality tests in quantitative genetics provide a statistical framework for the detection of selection on polygenic traits in wild populations. However, the existing method based on comparisons of divergence at neutral markers and quantitative traits (Q(st)-F(st)) suffers from several limitations that hinder a clear interpretation of the results with typical empirical designs. In this article, we propose a multivariate extension of this neutrality test based on empirical estimates of the among-populations (D) and within-populations (G) covariance matrices by MANOVA. A simple pattern is expected under neutrality: D = 2F(st)/(1 - F(st))G, so that neutrality implies both proportionality of the two matrices and a specific value of the proportionality coefficient. This pattern is tested using Flury's framework for matrix comparison [common principal-component (CPC) analysis], a well-known tool in G matrix evolution studies. We show the importance of using a Bartlett adjustment of the test for the small sample sizes typically found in empirical studies. We propose a dual test: (i) that the proportionality coefficient is not different from its neutral expectation [2F(st)/(1 - F(st))] and (ii) that the MANOVA estimates of mean square matrices between and among populations are proportional. These two tests combined provide a more stringent test for neutrality than the classic Q(st)-F(st) comparison and avoid several statistical problems. Extensive simulations of realistic empirical designs suggest that these tests correctly detect the expected pattern under neutrality and have enough power to efficiently detect mild to strong selection (homogeneous, heterogeneous, or mixed) when it is occurring on a set of traits. This method also provides a rigorous and quantitative framework for disentangling the effects of different selection regimes and of drift on the evolution of the G matrix. We discuss practical requirements for the proper application of our test in empirical

  15. Heuristic computation of the rovibrational G matrix in optimized molecule-fixed axes. Gmat 2.1

    NASA Astrophysics Data System (ADS)

    Castro, M. E.; Niño, A.; Muñoz-Caro, C.

    2010-08-01

    Gmat 2.1 is a program able to compute the rovibrational G matrix in different molecule-fixed axes extending the capabilities of Gmat 1.0. The present version is able to select optimal molecule-fixed axes minimizing the pure rotational kinetic elements, the rovibrational kinetic elements or both simultaneously. To such an end, it uses a hybrid minimization approach. Thus, it combines a global search heuristic based in simulated annealing with a gradient-free local minimization. As the previous version, the program handles the structural results of potential energy hypersurface mappings computed in computer clusters or computational Grid environments. However, since now more general molecule-fixed axes can be defined, a procedure is implemented to ensure the same minimum of the cost function is used in all the molecular structures. In addition, an algorithm for the unambiguous definition of the molecule-fixed axes orientation is used. Program summaryProgram title: Gmat 2.1 Catalogue identifier: AECZ_v2_0 Program summary URL:http://cpc.cs.qub.ac.uk/summaries/AECZ_v2_0.html Program obtainable from: CPC Program Library, Queen's University, Belfast, N. Ireland Licensing provisions: Standard CPC licence, http://cpc.cs.qub.ac.uk/licence/licence.html No. of lines in distributed program, including test data, etc.: 52 555 No. of bytes in distributed program, including test data, etc.: 932 366 Distribution format: tar.gz Programming language: Standard ANSI C++ Computer: All Operating system: Linux, Windows Classification: 16.2 Catalogue identifier of previous version: AECZ_v1_0 Journal reference of previous version: Comput. Phys. Comm. 180 (2009) 1183 Does the new version supersede the previous version?: Yes Nature of problem: When building molecular rovibrational Hamiltonians, the kinetic terms depend on the molecule-fixed axes orientation. Thus, an appropriate orientation can significantly simplify the treatment of pure rotation and rovibrational coupling. The kinetic terms

  16. Petrochemical variation of Topopah Spring tuff matrix with depth (stratigraphic level), drill hole USW G-4, Yucca Mountain, Nevada

    SciTech Connect

    Byers, F.M. Jr.

    1985-12-01

    This study describes and interprets petrochemical variation of the matrix (excluding fractures and large gas cavities) of the Topopah Spring Member of the Paintbrush Tuff. This tuff includes the candidate host rock for a high-level nuclear waste repository at Yucca Mountain on the Nevada Test Site. Cored hole USW G-4, near the site of a potential exploratory shaft at Yucca Mountain, penetrated 359.4 m (1179 ft) of the member within the unsaturated zone. This study shows that petrographic textures and chemistry of the matrix vary systematically within recognizable lithologic subunits related to crystallization (cooling) zones, welding (compaction) zones, and compositional zones (rhyolite versus quartz latite). The methods used for this study include petrographic modal thin section analysis using an automated counter and electron microprobe analysis of the groundmass. Distinctive textural categories are defined, and they can be ranked from finest to coarsest as vitrophyre (glass), cryptocrystalline groundmass, spherulites, granophyre, lithic fragments, and phenocrysts. The two main groundmass compositions are also defined: rhyolite high silica) and quartz latite. The value of these petrochemical studies lies in providing microscopic criteria for recognizing the zonal subunits where they may have greatly limited exposure, as in mined drifts and in core from horizontal drill holes. For example, the lower nonlithophysal zone can be distinguished microscopically from the middle nonlithophysal zone by (1) degree of compaction, (2) amount of quartz, and (3) amount of lithic fragments. The variability between these textural categories should also be considered in designing physical and chemical tests of the Topopah Spring.

  17. Induction of matrix metalloprotease-1 gene expression by retinoic acid in the human pancreatic tumour cell line Dan-G

    PubMed Central

    Marschall, Z von; Riecken, E-O; Rosewicz, S

    1999-01-01

    We have investigated the effects of retinoic acid (RA) on matrix metalloprotease-1 (MMP-1) gene expression in the human pancreatic tumour cell line Dan-G. 13-cis RA results in a time- and dose-dependent increase of MMP-1 protein concentration. These stimulatory effects were paralleled by a time- and dose-dependent increase of MMP-1 mRNA steady-state concentrations. Nuclear run-on analysis revealed that the increase of MMP-1 mRNA was partially due to an increase of MMP-1 gene transcription. In addition, 13-cis RA treatment results in an increase of MMP-1 mRNA stability. These data demonstrate that RA stimulates MMP-1 gene expression in human pancreatic carcinoma cells by transcriptional and post-transcriptional mechanisms. © 1999 Cancer Research Campaign PMID:10362099

  18. Influence of Carbopol 71G-NF on the release of dextromethorphan hydrobromide from extended-release matrix tablets.

    PubMed

    Fayed, Mohamed H; Mahrous, Gamal M; Ibrahim, Mohamed A; Sakr, Adel

    2013-01-01

    The objective of this study was to evaluate the potential of Carbopol(®) 71G-NF on the release of dextromethorphan hydrobromide (DM) from matrix tablets in comparison with hydroxypropyl methylcellulose (HPMC(®) K15M) and Eudragit(®) L100-55 polymers. Controlled release DM matrix tablets were prepared using Carbopol 71G-NF, HPMC K15M, and Eudragit L100-55 at different drug to polymer ratios by direct compression technique. The mechanical properties of the tablets as tested by crushing strength and friability tests were improved as the concentration of Carbopol, HPMC, and Eudragit increased. However, Carbopol-based tablets showed a significantly (P<0.05) higher crushing strength and a lower friability than HPMC and Eudragit tablets. No significant differences in weight uniformity and thickness values were observed between the different formulations. It was also found that Carbopol significantly (P<0.05) delayed the release of DM in comparison with HPMC K15M and Eudragit L100-55. A combination of HPMC K15M and Eudragit L100-55 in a 1:1 ratio at 20 and 30% significantly (P<0.05) delayed the release of DM than Eudragit L100-55 alone. Moreover, blends of Carbopol and HPMC at a 1:1 ratio at the 10, 20, and 30% total polymer concentration were investigated. The blend of Carbopol and HPMC at 10% level significantly (P<0.05) slowed the release of DM than Carbopol or HPMC alone, whereas blends at 20 and 30% level significantly (P<0.05) delayed the release of DM compared with HPMC or Carbopol alone. The results with these polymer blends showed that it was possible to reduce the total amount of polymers when used as a combination in formulation.

  19. Influence of matrix metalloproteinase-1 gene -1607 (1G/2G) (rs1799750) promoter polymorphism on circulating levels of MMP-1 in chronic pancreatitis.

    PubMed

    Sri Manjari, K; Nallari, Pratibha; Balakrishna, N; Vidyasagar, A; Prabhakar, B; Jyothy, A; Venkateshwari, A

    2013-08-01

    This study investigated the role of -1607 (1G/2G) (rs1799750) polymorphism of the MMP-1 gene in chronic pancreatitis. We genotyped 100 patients with chronic pancreatitis and 100 control subjects using tetra-primer ARMS-PCR followed by agarose gel electrophoresis. Serum levels of MMP-1 were determined by Elisa. Statistical analysis was applied to test the significance of the results. The genotypic and allelic distribution varied significantly between the disease group and the control subjects [OD = 1.981 (1.236-3.181), p = 0.004]. MMP-1 levels were higher in subjects homozygous for the 2G allele than in subjects with the 1G allele. The present study revealed a significant association of the MMP-1 -1607 1G/2G (rs1799750) gene promoter polymorphism with chronic pancreatitis, and it can be considered a biological marker in the etiology of chronic pancreatitis.

  20. Effects of selection and drift on G matrix evolution in a heterogeneous environment: a multivariate Qst-Fst Test with the freshwater snail Galba truncatula.

    PubMed

    Chapuis, Elodie; Martin, Guillaume; Goudet, Jérôme

    2008-12-01

    Unraveling the effect of selection vs. drift on the evolution of quantitative traits is commonly achieved by one of two methods. Either one contrasts population differentiation estimates for genetic markers and quantitative traits (the Q(st)-F(st) contrast) or multivariate methods are used to study the covariance between sets of traits. In particular, many studies have focused on the genetic variance-covariance matrix (the G matrix). However, both drift and selection can cause changes in G. To understand their joint effects, we recently combined the two methods into a single test (accompanying article by Martin et al.), which we apply here to a network of 16 natural populations of the freshwater snail Galba truncatula. Using this new neutrality test, extended to hierarchical population structures, we studied the multivariate equivalent of the Q(st)-F(st) contrast for several life-history traits of G. truncatula. We found strong evidence of selection acting on multivariate phenotypes. Selection was homogeneous among populations within each habitat and heterogeneous between habitats. We found that the G matrices were relatively stable within each habitat, with proportionality between the among-populations (D) and the within-populations (G) covariance matrices. The effect of habitat heterogeneity is to break this proportionality because of selection for habitat-dependent optima. Individual-based simulations mimicking our empirical system confirmed that these patterns are expected under the selective regime inferred. We show that homogenizing selection can mimic some effect of drift on the G matrix (G and D almost proportional), but that incorporating information from molecular markers (multivariate Q(st)-F(st)) allows disentangling the two effects.

  1. Inelastic scattering matrix elements for the nonadiabatic collision B(2P1/2)+H2(1Σg+,j)<-->B(2P3/2)+H2(1Σg+,j')

    NASA Astrophysics Data System (ADS)

    Weeks, David E.; Niday, Thomas A.; Yang, Sang H.

    2006-10-01

    Inelastic scattering matrix elements for the nonadiabatic collision B(P1/22)+H2(Σg+1,j)↔B(P3/22)+H2(Σg+1,j') are calculated using the time dependent channel packet method (CPM). The calculation employs 1A'2, 2A'2, and 1A″2 adiabatic electronic potential energy surfaces determined by numerical computation at the multireference configuration-interaction level [M. H. Alexander, J. Chem. Phys. 99, 6041 (1993)]. The 1A'2 and 2A'2, adiabatic electronic potential energy surfaces are transformed to yield diabatic electronic potential energy surfaces that, when combined with the total B +H2 rotational kinetic energy, yield a set of effective potential energy surfaces [M. H. Alexander et al., J. Chem. Phys. 103, 7956 (1995)]. Within the framework of the CPM, the number of effective potential energy surfaces used for the scattering matrix calculation is then determined by the size of the angular momentum basis used as a representation. Twenty basis vectors are employed for these calculations, and the corresponding effective potential energy surfaces are identified in the asymptotic limit by the H2 rotor quantum numbers j =0, 2, 4, 6 and B electronic states Pja2, ja=1/2, 3/2. Scattering matrix elements are obtained from the Fourier transform of the correlation function between channel packets evolving in time on these effective potential energy surfaces. For these calculations the H2 bond length is constrained to a constant value of req=1.402a.u. and state to state scattering matrix elements corresponding to a total angular momentum of J =1/2 are discussed for j =0↔j'=0,2,4 and P1/22↔P1/22, P3/22 over a range of total energy between 0.0 and 0.01a.u.

  2. Interlaminar G(IIc) evaluation of toughened-resin matrix composites using the end-notched flexure test

    NASA Technical Reports Server (NTRS)

    Murri, G. B.; Obrien, T. K.

    1985-01-01

    The usefulness of the end-notched flexure (ENF) test for measuring G(IIc) for toughened composites was evaluated. Calculations were made using the measured flexural compliance from the ENF test and the measured axial modulus. Tests were conducted on three different composite materials, using laminates with two different span lengths and insert sizes. The error associated with neglecting nonlinear terms in the displacement-curvature relationship was analyzed to demonstrate the influence of specimen geometry on G(IIc) measurement. It is concluded that G(IIc) measurement may vary with the method of calculation, span length, or insert thickness, but these effects are minor compared to the large differences in measurements obtained for different materials. Hence, the ENF test is a valid one for screening materials for improvements in interlaminar shear fracture toughness.

  3. Modulation of interactions of neuroblastoma cell lines with extracellular matrix proteins affects their sensitivity to treatment with the anti-GD2 ganglioside antibody 14G2a.

    PubMed

    Horwacik, Irena; Rokita, Hanna

    2017-05-01

    Children diagnosed with high risk neuroblastoma have poor prognosis which stimulates efforts to broaden therapies of the neoplasm. GD2-ganglioside (GD2) marks neuroblastoma cells and is a target for monoclonal antibodies. We have recently shown that some neuroblastoma cell lines are sensitive to direct cytotoxicity of the anti-GD2 mouse monoclonal antibody 14G2a (mAb). For IMR-32 and LA-N-1 cell lines, treatment with the 14G2a mAb induced evident changes in appearance such as cell rounding, aggregation, loose contact with culture plastic, or detachment. Such findings prompted us to investigate whether modulation of attachment of neuroblastoma cells to extracellular matrix (ECM) proteins can affect their sensitivity to the 14G2a mAb treatment. First, using ultra-low attachment plates, we show that survival of the IMR-32, LA-N-1, LA-N-5, CHP-134 and Kelly cells depends on attachment. Next, we compared cellular ATP levels of the cell lines treated with the 14G2a mAb using uncoated, fibronectin-, collagen IV-coated surfaces to show that the ECM proteins slightly modulate sensitivity of the cell lines to the mAb. Then, we characterized presence of selected integrin subunits or their complexes on the cell surface. Finally, we applied small molecule inhibitors of selected integrin complexes: obtustatin (inhibiting α1β1 heterodimer), BIO 1211 (inhibiting active α4β1 heterodimer), cilengitide and SB273005 (inhibitors of αVβ3, αVβ5 heterodimers) to verify their effects on attachment of cell lines, cellular ATP levels, and in some experiments activities of apoptosis-executing caspase-3 and -7, for the compounds used alone or in combination with the 14G2a mAb. We characterized levels of total FAK (focal adhesion kinase), p-FAK (Tyr397) in IMR-32 cells treated with BIO 1211, and in LA-N-5, Kelly and SK-N-SH cells treated with SB273005. Our results extend knowledge on factors influencing cytotoxicity of 14G2a.

  4. Sub-barrier fusion calculations for the neutron star crust using the microscopic Brueckner G -matrix and Skyrme energy density functionals

    NASA Astrophysics Data System (ADS)

    Rashdan, M.

    2015-05-01

    Sub-barrier fusion cross sections for reactions involving stable and very neutron-rich nuclei, which may be important in determining the composition and heating of the crust of accreting neutron stars, are calculated using internuclear potentials derived from the microscopic Brueckner G -matrix and Skyrme SKM* and SLy4 energy density functionals. Microscopic Skyrme-Hartree-Fock proton and neutron density distributions are used. No parameters have been fit to fusion data. Calculations are performed for the isotopic reactions 16O+16O,16O+24O,16O+28O,24O+24O,12C+16O,12C+24O , and 12C+12C , which are of great astrophysical importance for the understanding of the time scale and the nucleosynthesis during late stellar evolution. The coupling to the low lying excited states is considered through the ccfull code. I compare my results with the time-dependent-Hartree-Fock calculations and with the São Paulo model as well as the experimental data. I found a remarkable agreement with the fusion cross sections for stable nuclei.

  5. Electron spin resonance g tensors for complexes of Ne and Ar with AlO: Theoretical studies related to the large matrix effect observed for AlO

    NASA Astrophysics Data System (ADS)

    Grein, Friedrich

    2005-03-01

    For Nen-AlO (n=2, 4, 6, 8, 10) and Arn-AlO clusters (n=2, 4, 6, 8), the perpendicular (relative to AlO) component of the g tensor was calculated by second-order perturbation theory, using multireference configuration-interaction wave functions. The rare-gas (Rg) atoms were placed axially and/or off axially (one or two rings of four Rg atoms each), and the distance of the Rg atoms from the Al and O atoms, or from the AlO axis, was varied from 4 to 12 bohrs. Rg atoms placed axially mostly increase g⊥, whereas off-axially placed ones lower it below the gas-phase value of AlO. The largest deviations from g⊥ of isolated AlO occur at Ne-Al,O distances of 5-6 bohrs, and Ar-Al,O distances of 6-9 bohrs, with maximal lowerings of about 1600 ppm for Ne and about 2200 ppm (estimated) for Ar in the case of two axial and eight off-axial Rg atoms. Electron spin resonance studies by Knight and Weltner found large matrix effects for AlO, with downshifts of g⊥ observed to be about 450 and 1150 ppm in Ne and Ar matrices, respectively.

  6. D1(2B2g)→D0(2Au) fluorescence from the matrix-isolated perylene cation following laser excitation into the D5(2B3g) and D2(2B3g) electronic states

    NASA Astrophysics Data System (ADS)

    Chillier, Xavier D. F.; Stone, Bradley M.; Joblin, Christine; Salama, Farid; Allamandola, Louis J.

    2002-04-01

    Fluorescence spectra of the perylene cation, isolated in an argon matrix and pumped by direct laser excitation via the D2(2B3g)←D0(2Au) and D5(2B3g)←D0(2Au) transitions, are presented. Direct excitation into the D5 or D2 states is followed by rapid nonradiative relaxation to D1 that, in turn, relaxes radiatively. Excitation spectroscopy across the D2(2B3g)←D0(2Au) transition near 731 nm shows that site splitting plays little or no role in determining the spectral substructure in the ion spectra. Tentative assignments for ground state vibrational frequencies are made by a comparison of spectral intervals with calculated normal mode frequencies, with the strongest IR bands leading to the most intense vibronic bands.

  7. Semaphorin7A Promotion of Tumoral Growth and Metastasis in Human Oral Cancer by Regulation of G1 Cell Cycle and Matrix Metalloproteases: Possible Contribution to Tumoral Angiogenesis

    PubMed Central

    Saito, Tomoaki; Kasamatsu, Atsushi; Ogawara, Katsunori; Miyamoto, Isao; Saito, Kengo; Iyoda, Manabu; Suzuki, Takane; Endo-Sakamoto, Yosuke; Shiiba, Masashi; Tanzawa, Hideki; Uzawa, Katsuhiro

    2015-01-01

    Background Semaphorins (SEMAs) consist of a large family of secreted and membrane-anchored proteins that are important in neuronal pathfinding and axon guidance in selected areas of the developing nervous system. Of them, SEMA7A has been reported to have a chemotactic activity in neurogenesis and to be an immunomodulator; however, little is known about the relevance of SEMA7A in the behaviors of oral squamous cell carcinoma (OSCC). Methods We evaluated SEMA7A expression in OSCC-derived cell lines and primary OSCC samples using quantitative reverse transcriptase-polymerase chain reaction, immunoblotting, and semiquantitative immunohistochemistry (sq-IHC). In addition, SEMA7A knockdown cells (shSEMA7A cells) were used for functional experiments, including cellular proliferation, invasiveness, and migration assays. We also analyzed the clinical correlation between SEMA7A status and clinical behaviors in patients with OSCC. Results SEMA7A mRNA and protein were up-regulated significantly (P<0.05) in OSCC-derived cell lines compared with human normal oral keratinocytes. The shSEMA7A cells showed decreased cellular growth by cell-cycle arrest at the G1 phase, resulting from up-regulation of cyclin-dependent kinase inhibitors (p21Cip1 and p27Kip1) and down-regulation of cyclins (cyclin D1, cyclin E) and cyclin-dependent kinases (CDK2, CDK4, and CDK6); and decreased invasiveness and migration activities by reduced secretion of matrix metalloproteases (MMPs) (MMP-2, proMMP-2, pro-MMP-9), and expression of membrane type 1- MMP (MT1-MMP). We also found inactivation of the extracellular regulated kinase 1/2 and AKT pathways, an upstream molecule of cell-cycle arrest at the G1 phase, and reduced secretion of MMPs in shSEMA7A cells. sq-IHC showed that SEMA7A expression in the primary OSCCs was significantly (P = 0.001) greater than that in normal counterparts and was correlated with primary tumoral size (P = 0.0254) and regional lymph node metastasis (P = 0.0002). Conclusion Our

  8. Matrix protein CCN1 induced by bacterial DNA and CpG ODN limits lung inflammation and contributes to innate immune homeostasis.

    PubMed

    Moon, H-G; Qin, Z; Quan, T; Xie, L; Dela Cruz, C S; Jin, Y

    2015-03-01

    To defend against pulmonary infections, lung epithelial cells are equipped with complex innate immunity closely linked to inflammation. Dysregulated innate immunity/inflammation leads to self-perpetuating lung injury. The CpG motif in bacterial DNA is one of the factors involved in bacterial infection-associated inflammation. Bacterial DNA and synthetic CpG oligonucleotide (ODN) induced CCN1 secretion from lung epithelial cells, functioning as a potential "braking" signal to prevent uncontrolled inflammatory responses. CpG ODN-induced endoplasmic reticulum (ER) stress resulted in Src-Y527 phosphorylation (pY527) and Src/CCN1 vWF domain dissociation. Src-Y527 activated caveolin-1 (cav-1) phosphorylation at Y14 and then modulated CCN1 secretion via pCav-1 interaction with the CCN1 IGFbp domain. Functionally, secreted CCN1 promoted anti-inflammatory cytokine interleukin (IL)-10 release from epithelial cells via integrin αVβ6-PKC, and this subsequently suppressed tumor necrosis factor (TNF)-α, macrophage inflammatory protein 2 (MIP-2)-2 secretion and neutrophil infiltration in the lungs. Collectively, bacterial DNA/CpG ODN-stimulated CCN1 secretion via the BiP/GRP78-Src(Y527)-JNK-Cav-1(Y14) pathway and CpG-induced CCN1 conferred anti-inflammatory roles. Our studies suggested a novel paradigm by which the lung epithelium maintains innate immune homeostasis after bacterial infection.

  9. Placing Intelligence into an Evolutionary Framework or How "g" Fits into the "r-K" Matrix of Life-History Traits Including Longevity

    ERIC Educational Resources Information Center

    Rushton, J. Philippe

    2004-01-01

    First, I describe why intelligence (Spearman's "g") can only be fully understood through "r-K" theory, which places it into an evolutionary framework along with brain size, longevity, maturation speed, and several other life-history traits. The "r-K" formulation explains why IQ predicts longevity and also why the gap in mortality rates between…

  10. Calculation of S-matrix poles by means of analytic continuation in the coupling constant: Application to the 2Πg state of N2-

    NASA Astrophysics Data System (ADS)

    Horáček, J.; Mach, P.; Urban, J.

    2010-09-01

    The method of analytic continuation in the coupling constant in combination with use of the statistical Padé approximation is applied to the determination of resonance energy and width of the 2Πg state of N2-. It is shown that standard quantum chemistry codes provide accurate data which can be used for analytic continuation in the coupling constant, and the resonance energy and width can be inferred with an accuracy comparable to other more elaborate methods.

  11. Fuzzy risk matrix.

    PubMed

    Markowski, Adam S; Mannan, M Sam

    2008-11-15

    A risk matrix is a mechanism to characterize and rank process risks that are typically identified through one or more multifunctional reviews (e.g., process hazard analysis, audits, or incident investigation). This paper describes a procedure for developing a fuzzy risk matrix that may be used for emerging fuzzy logic applications in different safety analyses (e.g., LOPA). The fuzzification of frequency and severity of the consequences of the incident scenario are described which are basic inputs for fuzzy risk matrix. Subsequently using different design of risk matrix, fuzzy rules are established enabling the development of fuzzy risk matrices. Three types of fuzzy risk matrix have been developed (low-cost, standard, and high-cost), and using a distillation column case study, the effect of the design on final defuzzified risk index is demonstrated.

  12. Optical coherency matrix tomography

    PubMed Central

    Kagalwala, Kumel H.; Kondakci, H. Esat; Abouraddy, Ayman F.; Saleh, Bahaa E. A.

    2015-01-01

    The coherence of an optical beam having multiple degrees of freedom (DoFs) is described by a coherency matrix G spanning these DoFs. This optical coherency matrix has not been measured in its entirety to date—even in the simplest case of two binary DoFs where G is a 4 × 4 matrix. We establish a methodical yet versatile approach—optical coherency matrix tomography—for reconstructing G that exploits the analogy between this problem in classical optics and that of tomographically reconstructing the density matrix associated with multipartite quantum states in quantum information science. Here G is reconstructed from a minimal set of linearly independent measurements, each a cascade of projective measurements for each DoF. We report the first experimental measurements of the 4 × 4 coherency matrix G associated with an electromagnetic beam in which polarization and a spatial DoF are relevant, ranging from the traditional two-point Young’s double slit to spatial parity and orbital angular momentum modes. PMID:26478452

  13. The Inhibitory Effect of C-phycocyanin Containing Protein Extract (C-PC Extract) on Human Matrix Metalloproteinases (MMP-2 and MMP-9) in Hepatocellular Cancer Cell Line (HepG2).

    PubMed

    Kunte, Mugdha; Desai, Krutika

    2017-03-30

    Spirulina platensis :have been studied for several biological activities. In the current study C-phycocyanin containing protein extract (C-PC extract) of Spirulina platensis have been studied for its effect on human matrix metalloproteinases (MMP-1, MMP-2 and MMP-9) and tissue inhibitors of MMPs (TIMP-1 and TIMP-2). In the present study, breast cancer cell line (MDA-MB 231) and hepatocellular cancer cell line (HepG2) were examined for inhibition of MMPs at different levels of expression after C-PC extract treatment. Herein, we have demonstrated that C-PC extract significantly reduced activity of MMP-2 by 55.13% and MMP-9 by 57.9% in HepG2 cells at 15 μg concentration. Additionally, the treatment has reduced mRNA expression of MMP-2 and MMP-9 at 20 μg concentration by 1.65-folds and 1.66-folds respectively. The C-PC extract treatment have also downregulated a mRNA expression of TIMP-2 by 1.12 folds at 20 μg concentration in HepG2 cells. Together, these results indicate that C-PC, extract successfully inhibited MMP-2 and -9 at different levels of expression and TIMP-2 at a mRNA expression level; however, extract did not have any effect on MMP-1 expressed in MDA-MB231 and TIMP-1 expressed in HepG2 cells as well as the exact mechanism of inhibition of MMP-2, MMP-9 and TIMP-2 remained unclear.

  14. Rheocasting Al Matrix Composites

    NASA Astrophysics Data System (ADS)

    Girot, F. A.; Albingre, L.; Quenisset, J. M.; Naslain, R.

    1987-11-01

    Aluminum alloy matrix composites reinforced by SiC short fibers (or whiskers) can be prepared by rheocasting, a process which consists of the incorporation and homogeneous distribution of the reinforcement by stirring within a semi-solid alloy. Using this technique, composites containing fiber volume fractions in the range of 8-15%, have been obtained for various fibers lengths (i.e., 1 mm, 3 mm and 6 mm for SiC fibers). This paper attempts to delineate the best compocasting conditions for aluminum matrix composites reinforced by short SiC (e.g Nicalon) or SiC whiskers (e.g., Tokamax) and characterize the resulting microstructures.

  15. Matrix thermalization

    NASA Astrophysics Data System (ADS)

    Craps, Ben; Evnin, Oleg; Nguyen, Kévin

    2017-02-01

    Matrix quantum mechanics offers an attractive environment for discussing gravitational holography, in which both sides of the holographic duality are well-defined. Similarly to higher-dimensional implementations of holography, collapsing shell solutions in the gravitational bulk correspond in this setting to thermalization processes in the dual quantum mechanical theory. We construct an explicit, fully nonlinear supergravity solution describing a generic collapsing dilaton shell, specify the holographic renormalization prescriptions necessary for computing the relevant boundary observables, and apply them to evaluating thermalizing two-point correlation functions in the dual matrix theory.

  16. Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) for detection and identification of albumin phosphylation by organophosphorus pesticides and G- and V-type nerve agents.

    PubMed

    John, Harald; Breyer, Felicitas; Thumfart, Jörg Oliver; Höchstetter, Hans; Thiermann, Horst

    2010-11-01

    Toxic organophosphorus compounds (OPC), e.g., pesticides and nerve agents (NA), are known to phosphylate distinct endogenous proteins in vivo and in vitro. OPC adducts of butyrylcholinesterase and albumin are considered to be valuable biomarkers for retrospective verification of OPC exposure. Therefore, we have detected and identified novel adducts of human serum albumin (HSA) by means of matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS). Pure albumin and plasma were incubated with numerous pesticides and NA of the V- and G-type in different molar ratios. Samples were prepared either by sodium dodecyl sulfate-polyacrylamide gel electrophoresis followed by in-gel enzymatic cleavage using endoproteinase Glu-C (Glu-C) or by combining highly albumin-selective affinity extraction with ultrafiltration followed by reduction, carbamidomethylation, and enzymatic cleavage (Glu-C) prior to MALDI-TOF MS analysis. Characteristic mass shifts for phosphylation revealed tyrosine adducts at Y(411) (Y(401)KFQNALLVRY(411)TKKVPQVSTPTLVE(425)), Y(148) and Y(150) (I(142)ARRHPY(148)FY(150)APE(153), single and double labeled), and Y(161) (L(154)LFFAKRY(161)KAAFTE(167)) produced by original NA (tabun, sarin, soman, cyclosarin, VX, Chinese VX, and Russian VX) as well as by chlorpyrifos-oxon, diisopropyl fluorophosphate (DFP), paraoxon-ethyl (POE), and profenofos. MALDI-MS/MS of the single-labeled I(142)-E(153) peptide demonstrated that Y(150) was phosphylated with preference to Y(148). Aged albumin adducts were not detected. The procedure described was reproducible and feasible for detection of adducts at the most reactive Y(411)-residue (S/N ≥ 3) when at least 1% of total albumin was labeled. This was achieved by incubating plasma with molar HSA/OPC ratios ranging from approximately 1:0.03 (all G-type NA, DFP, and POE) to 1:3 (V-type NA, profenofos). Relative signal intensity of the Y(411) adduct correlated well with the spotted relative

  17. Sync Matrix

    SciTech Connect

    Metz, William C.; Metz, W. Chris; Mitrani, Jacques E.; Hewett, Jr., Paul L.; Jones, Christopher A.

    2004-12-31

    Sync Matrix provides a graphic display of the relationships among all of the response activities of each jurisdiction. This is accomplished through software that organizes and displays the activities by jurisdiction, function, and time for easy review and analysis. The software can also integrate the displays of multiple jurisdictions to allow examination of the total response.

  18. D1((2)B2g) to D0((2)Au) Fluorescence from the Matrix-Isolated Perylene Cation Following Laser Excitation into the D5(2)B3g) and D2 ((2)B3g) Electronic States

    NASA Technical Reports Server (NTRS)

    Chillier, Xavier D. F.; Stone, Bradley M.; Joblin, Christine; Salama, Farid; Allamandola, Louis J.; DeVincenzi, Donald L. (Technical Monitor)

    2001-01-01

    Fluorescence spectra of the perylene cation, pumped by direct laser excitation via the D(sub 2)((2)B(sub 3g)) (left arrow) D(sub 0)((2)A(sub u)) and D(sub 5)(2)B(sub 3g)) (left arrow) D(sub 0)((2)A(sub u)) transitions, are presented. Direct excitation into the D5 or D2 states is followed by rapid non-radiative relaxation to D1 that, in turn,relaxes radiatively. Excitation spectroscopy across the D(sub 2)((2)B(sub 3g)) (left arrow) D(sub 0)((2)A(sub u)) transition near 730 nm shows that site splitting plays little or no role in determining the spectral substructure in the ion spectra. Tentative assignments for ground state vibrational frequencies are made by comparison of spectral intervals with calculated normal mode frequencies.

  19. The S228P Mutation Prevents in Vivo and in Vitro IgG4 Fab-arm Exchange as Demonstrated using a Combination of Novel Quantitative Immunoassays and Physiological Matrix Preparation

    PubMed Central

    Silva, John-Paul; Vetterlein, Olivia; Jose, Joby; Peters, Shirley; Kirby, Hishani

    2015-01-01

    Human immunoglobulin G isotype 4 (IgG4) antibodies (Abs) are potential candidates for immunotherapy when reduced effector functions are desirable. IgG4 Abs are dynamic molecules able to undergo a process known as Fab arm exchange (FAE). This results in functionally monovalent, bispecific antibodies (bsAbs) with unknown specificity and hence, potentially, reduced therapeutic efficacy. IgG4 FAE is suggested to be an important biological mechanism that provides the basis for the anti-inflammatory activity attributed to IgG4 Abs. To date, the mechanism of FAE is not entirely understood and studies measuring FAE in ex vivo matrices have been hampered by the presence and abundance of endogenous IgG4 wild-type (WT) Abs. Using representative humanized WT IgG4 monoclonal Abs, namely, anti-IL-6 and anti-TNF, and a core-hinge stabilized serine 228 to proline (S228P) anti-IL-6 IgG4 mutant, it is demonstrated for the first time how anti-IgG4 affinity chromatography can be used to prepare physiologically relevant matrices for assessing and quantifying FAE. A novel method for quantifying FAE using a single MSD immunoassay is also reported and confirms previous findings that, dependent on the redox conditions, the S228P mutation can prevent IgG4 FAE to undetectable levels both in vitro and in vivo. Together, the findings and novel methodologies will allow researchers to monitor and quantify FAE of their own IgG4 molecules in physiologically relevant matrices. PMID:25568323

  20. The S228P mutation prevents in vivo and in vitro IgG4 Fab-arm exchange as demonstrated using a combination of novel quantitative immunoassays and physiological matrix preparation.

    PubMed

    Silva, John-Paul; Vetterlein, Olivia; Jose, Joby; Peters, Shirley; Kirby, Hishani

    2015-02-27

    Human immunoglobulin G isotype 4 (IgG4) antibodies (Abs) are potential candidates for immunotherapy when reduced effector functions are desirable. IgG4 Abs are dynamic molecules able to undergo a process known as Fab arm exchange (FAE). This results in functionally monovalent, bispecific antibodies (bsAbs) with unknown specificity and hence, potentially, reduced therapeutic efficacy. IgG4 FAE is suggested to be an important biological mechanism that provides the basis for the anti-inflammatory activity attributed to IgG4 Abs. To date, the mechanism of FAE is not entirely understood and studies measuring FAE in ex vivo matrices have been hampered by the presence and abundance of endogenous IgG4 wild-type (WT) Abs. Using representative humanized WT IgG4 monoclonal Abs, namely, anti-IL-6 and anti-TNF, and a core-hinge stabilized serine 228 to proline (S228P) anti-IL-6 IgG4 mutant, it is demonstrated for the first time how anti-IgG4 affinity chromatography can be used to prepare physiologically relevant matrices for assessing and quantifying FAE. A novel method for quantifying FAE using a single MSD immunoassay is also reported and confirms previous findings that, dependent on the redox conditions, the S228P mutation can prevent IgG4 FAE to undetectable levels both in vitro and in vivo. Together, the findings and novel methodologies will allow researchers to monitor and quantify FAE of their own IgG4 molecules in physiologically relevant matrices.

  1. Regulated transcription of human matrix metalloproteinase 13 (MMP13) and interleukin-1β (IL1B) genes in chondrocytes depends on methylation of specific proximal promoter CpG sites.

    PubMed

    Hashimoto, Ko; Otero, Miguel; Imagawa, Kei; de Andrés, María C; Coico, Jonathan M; Roach, Helmtrud I; Oreffo, Richard O C; Marcu, Kenneth B; Goldring, Mary B

    2013-04-05

    The role of DNA methylation in the regulation of catabolic genes such as MMP13 and IL1B, which have sparse CpG islands, is poorly understood in the context of musculoskeletal diseases. We report that demethylation of specific CpG sites at -110 bp and -299 bp of the proximal MMP13 and IL1B promoters, respectively, detected by in situ methylation analysis of chondrocytes obtained directly from human cartilage, strongly correlated with higher levels of gene expression. The methylation status of these sites had a significant impact on promoter activities in chondrocytes, as revealed in transfection experiments with site-directed CpG mutants in a CpG-free luciferase reporter. Methylation of the -110 and -299 CpG sites, which reside within a hypoxia-inducible factor (HIF) consensus motif in the respective MMP13 and IL1B promoters, produced the most marked suppression of their transcriptional activities. Methylation of the -110 bp CpG site in the MMP13 promoter inhibited its HIF-2α-driven transactivation and decreased HIF-2α binding to the MMP13 proximal promoter in chromatin immunoprecipitation assays. In contrast to HIF-2α, MMP13 transcriptional regulation by other positive (RUNX2, AP-1, ELF3) and negative (Sp1, GATA1, and USF1) factors was not affected by methylation status. However, unlike the MMP13 promoter, IL1B was not susceptible to HIF-2α transactivation, indicating that the -299 CpG site in the IL1B promoter must interact with other transcription factors to modulate IL1B transcriptional activity. Taken together, our data reveal that the methylation of different CpG sites in the proximal promoters of the human MMP13 and IL1B genes modulates their transcription by distinct mechanisms.

  2. Hybrid matrix fiber composites

    DOEpatents

    Deteresa, Steven J.; Lyon, Richard E.; Groves, Scott E.

    2003-07-15

    Hybrid matrix fiber composites having enhanced compressive performance as well as enhanced stiffness, toughness and durability suitable for compression-critical applications. The methods for producing the fiber composites using matrix hybridization. The hybrid matrix fiber composites include two chemically or physically bonded matrix materials, whereas the first matrix materials are used to impregnate multi-filament fibers formed into ribbons and the second matrix material is placed around and between the fiber ribbons that are impregnated with the first matrix material and both matrix materials are cured and solidified.

  3. The role of g9/2 intruder state in the nuclear matrix elements of 76Ge → 76Se 2νββ(0+ → 0+) decay

    NASA Astrophysics Data System (ADS)

    Valencia, J. P.

    2016-07-01

    I propose a model for the upper-part of pf-shell, which consists of p1/2, p3/2, f5/2 and g9/2 single-particle orbits. While the pf-subshell (or d ˜s -subshell, i.e. η ˜=2 ,s˜1 /2,d˜3 /2,d˜5 /2) is governed by the SU˜S ˜T(4 )⊗U˜L ˜(6 ) symmetry, the g9/2 intruder state is governed by the seniority model. The nuclear states of 76Ge and 76Se are expressed as direct products of the d ˜s subshell component and the g-subshell one. The five-dimensional quasispin formalism with seniority zero restriction is used for a classification in the g-subshell. In the d ˜s -subshell, for each configuration [Mπ,Mν]d ˜s I choose only the most symmetric U˜L ˜(6 ) representations with total pseudo-spin S ˜=0 . Therefore, all the configurations are given by (0 Y 0 ˜) {4P2Y ˜} and (0 Y 0 -20 ˜) {4P +12Y -2 ˜} for 76Ge and 76Se, respectively with Y = 6-(nν - nπ)/2 and P = (4 - nπ)/2. I derive an explicit expression for the NME of the 2νββ(0+ → 0+) in the closure approximation.

  4. A matrix analysis of conjugate gradient algorithms

    SciTech Connect

    Ashby, S.F.; Gutknecht, M.H.

    1993-04-01

    This paper explores the relationships between the conjugate gradient algorithms Orthodir, Orthomin, and Orthores. To facilitate this exploration, a matrix formulation for each algorithm is given. It is shown that Orthodir directly computes a Hessenberg matrix H{sub k} at step k. Orthores also computes a Hessenberg matrix, G{sub k}, which is similar to a Hessenberg matrix obtained from H{sub k} by perturbing its last column. (This perturbation vanishes at convergence.) Orthomin, on the other hand, computes a UL and LU factorization of the perturbed H{sub k} and G{sub k}, respectively. The breakdown of Orthomin and Orthores are interpreted in terms of these underlying matrix factorizations. A connection with Lanczos algorithms is also examined, as is the special case of B-normal(1) matrices (for which efficient three-term CG algorithms exist).

  5. Carbonate fuel cell matrix

    DOEpatents

    Farooque, Mohammad; Yuh, Chao-Yi

    1996-01-01

    A carbonate fuel cell matrix comprising support particles and crack attenuator particles which are made platelet in shape to increase the resistance of the matrix to through cracking. Also disclosed is a matrix having porous crack attenuator particles and a matrix whose crack attenuator particles have a thermal coefficient of expansion which is significantly different from that of the support particles, and a method of making platelet-shaped crack attenuator particles.

  6. Matrix with Prescribed Eigenvectors

    ERIC Educational Resources Information Center

    Ahmad, Faiz

    2011-01-01

    It is a routine matter for undergraduates to find eigenvalues and eigenvectors of a given matrix. But the converse problem of finding a matrix with prescribed eigenvalues and eigenvectors is rarely discussed in elementary texts on linear algebra. This problem is related to the "spectral" decomposition of a matrix and has important technical…

  7. The intraclass covariance matrix.

    PubMed

    Carey, Gregory

    2005-09-01

    Introduced by C.R. Rao in 1945, the intraclass covariance matrix has seen little use in behavioral genetic research, despite the fact that it was developed to deal with family data. Here, I reintroduce this matrix, and outline its estimation and basic properties for data sets on pairs of relatives. The intraclass covariance matrix is appropriate whenever the research design or mathematical model treats the ordering of the members of a pair as random. Because the matrix has only one estimate of a population variance and covariance, both the observed matrix and the residual matrix from a fitted model are easy to inspect visually; there is no need to mentally average homologous statistics. Fitting a model to the intraclass matrix also gives the same log likelihood, likelihood-ratio (LR) chi2, and parameter estimates as fitting that model to the raw data. A major advantage of the intraclass matrix is that only two factors influence the LR chi2--the sampling error in estimating population parameters and the discrepancy between the model and the observed statistics. The more frequently used interclass covariance matrix adds a third factor to the chi2--sampling error of homologous statistics. Because of this, the degrees of freedom for fitting models to an intraclass matrix differ from fitting that model to an interclass matrix. Future research is needed to establish differences in power-if any--between the interclass and the intraclass matrix.

  8. Matrix Training of Preliteracy Skills with Preschoolers with Autism

    ERIC Educational Resources Information Center

    Axe, Judah B.; Sainato, Diane M.

    2010-01-01

    Matrix training is a generative approach to instruction in which words are arranged in a matrix so that some multiword phrases are taught and others emerge without direct teaching. We taught 4 preschoolers with autism to follow instructions to perform action-picture combinations (e.g., circle the pepper, underline the deer). Each matrix contained…

  9. Nanocrystal doped matrixes

    DOEpatents

    Parce, J. Wallace; Bernatis, Paul; Dubrow, Robert; Freeman, William P.; Gamoras, Joel; Kan, Shihai; Meisel, Andreas; Qian, Baixin; Whiteford, Jeffery A.; Ziebarth, Jonathan

    2010-01-12

    Matrixes doped with semiconductor nanocrystals are provided. In certain embodiments, the semiconductor nanocrystals have a size and composition such that they absorb or emit light at particular wavelengths. The nanocrystals can comprise ligands that allow for mixing with various matrix materials, including polymers, such that a minimal portion of light is scattered by the matrixes. The matrixes of the present invention can also be utilized in refractive index matching applications. In other embodiments, semiconductor nanocrystals are embedded within matrixes to form a nanocrystal density gradient, thereby creating an effective refractive index gradient. The matrixes of the present invention can also be used as filters and antireflective coatings on optical devices and as down-converting layers. Processes for producing matrixes comprising semiconductor nanocrystals are also provided. Nanostructures having high quantum efficiency, small size, and/or a narrow size distribution are also described, as are methods of producing indium phosphide nanostructures and core-shell nanostructures with Group II-VI shells.

  10. String coupling and interactions in type IIB matrix model

    SciTech Connect

    Kitazawa, Yoshihisa; Nagaoka, Satoshi

    2009-05-15

    We investigate the interactions of closed strings in a IIB matrix model. The basic interaction of the closed superstring is realized by the recombination of two intersecting strings. Such interaction is investigated in a IIB matrix model via two-dimensional noncommutative gauge theory in the IR limit. By estimating the probability of the recombination, we identify the string coupling g{sub s} in the IIB matrix model. We confirm that our identification is consistent with matrix string theory.

  11. An ESS maximum principle for matrix games.

    PubMed

    Vincent, T L; Cressman, R

    2000-11-01

    Previous work has demonstrated that for games defined by differential or difference equations with a continuum of strategies, there exists a G-function, related to individual fitness, that must take on a maximum with respect to a virtual variable v whenever v is one of the vectors in the coalition of vectors which make up the evolutionarily stable strategy (ESS). This result, called the ESS maximum principle, is quite useful in determining candidates for an ESS. This principle is reformulated here, so that it may be conveniently applied to matrix games. In particular, we define a matrix game to be one in which fitness is expressed in terms of strategy frequencies and a matrix of expected payoffs. It is shown that the G-function in the matrix game setting must again take on a maximum value at all the strategies which make up the ESS coalition vector. The reformulated maximum principle is applicable to both bilinear and nonlinear matrix games. One advantage in employing this principle to solve the traditional bilinear matrix game is that the same G-function is used to find both pure and mixed strategy solutions by simply specifying an appropriate strategy space. Furthermore we show how the theory may be used to solve matrix games which are not in the usual bilinear form. We examine in detail two nonlinear matrix games: the game between relatives and the sex ratio game. In both of these games an ESS solution is determined. These examples not only illustrate the usefulness of this approach to finding solutions to an expanded class of matrix games, but aids in understanding the nature of the ESS as well.

  12. Biofilm Matrix Proteins

    PubMed Central

    Fong, Jiunn N. C.; Yildiz, Fitnat H.

    2015-01-01

    Proteinaceous components of the biofilm matrix include secreted extracellular proteins, cell surface adhesins and protein subunits of cell appendages such as flagella and pili. Biofilm matrix proteins play diverse roles in biofilm formation and dissolution. They are involved in attaching cells to surfaces, stabilizing the biofilm matrix via interactions with exopolysaccharide and nucleic acid components, developing three-dimensional biofilm architectures, and dissolving biofilm matrix via enzymatic degradation of polysaccharides, proteins, and nucleic acids. In this chapter, we will review functions of matrix proteins in a selected set of microorganisms, studies of the matrix proteomes of Vibrio cholerae and Pseudomonas aeruginosa, and roles of outer membrane vesicles and of nucleoid-binding proteins in biofilm formation. PMID:26104709

  13. Reducibility of Matrix Equations Containing Several Parameters.

    DTIC Science & Technology

    1981-12-01

    AD-AI15 568 AIR FORCE INST OF TECH WRIGHT-PATTERSON AFB OH SCHOO;-ETC EF G 12 1ADA1551 REDUCIBILITY OF MATRIX EQUATIONS CONTAINING SEVERAL...PARAMETERS.E U)CA E UNCLASSIFIED AFIT/GE/RA/81D-1 N P11111111II soonhh Eu;o I. ’Trm * a, ~t- NMI 4 i’- 00Nt. met r~ REDUCIBILITY OF MATRIX EQUATIONS CONTAINING...1 REDUCIBILITY OF MATRIX EQUATIONS CONTAINING SEVERAL PARAMETERS THESIS Presented to the Faculty of the School of Engineering of the Air Force

  14. Automatic switching matrix

    DOEpatents

    Schlecht, Martin F.; Kassakian, John G.; Caloggero, Anthony J.; Rhodes, Bruce; Otten, David; Rasmussen, Neil

    1982-01-01

    An automatic switching matrix that includes an apertured matrix board containing a matrix of wires that can be interconnected at each aperture. Each aperture has associated therewith a conductive pin which, when fully inserted into the associated aperture, effects electrical connection between the wires within that particular aperture. Means is provided for automatically inserting the pins in a determined pattern and for removing all the pins to permit other interconnecting patterns.

  15. Hacking the Matrix.

    PubMed

    Czerwinski, Michael; Spence, Jason R

    2017-01-05

    Recently in Nature, Gjorevski et al. (2016) describe a fully defined synthetic hydrogel that mimics the extracellular matrix to support in vitro growth of intestinal stem cells and organoids. The hydrogel allows exquisite control over the chemical and physical in vitro niche and enables identification of regulatory properties of the matrix.

  16. Grassmann matrix quantum mechanics

    DOE PAGES

    Anninos, Dionysios; Denef, Frederik; Monten, Ruben

    2016-04-21

    We explore quantum mechanical theories whose fundamental degrees of freedom are rectangular matrices with Grassmann valued matrix elements. We study particular models where the low energy sector can be described in terms of a bosonic Hermitian matrix quantum mechanics. We describe the classical curved phase space that emerges in the low energy sector. The phase space lives on a compact Kähler manifold parameterized by a complex matrix, of the type discovered some time ago by Berezin. The emergence of a semiclassical bosonic matrix quantum mechanics at low energies requires that the original Grassmann matrices be in the long rectangular limit.more » In conclusion, we discuss possible holographic interpretations of such matrix models which, by construction, are endowed with a finite dimensional Hilbert space.« less

  17. Grassmann matrix quantum mechanics

    SciTech Connect

    Anninos, Dionysios; Denef, Frederik; Monten, Ruben

    2016-04-21

    We explore quantum mechanical theories whose fundamental degrees of freedom are rectangular matrices with Grassmann valued matrix elements. We study particular models where the low energy sector can be described in terms of a bosonic Hermitian matrix quantum mechanics. We describe the classical curved phase space that emerges in the low energy sector. The phase space lives on a compact Kähler manifold parameterized by a complex matrix, of the type discovered some time ago by Berezin. The emergence of a semiclassical bosonic matrix quantum mechanics at low energies requires that the original Grassmann matrices be in the long rectangular limit. In conclusion, we discuss possible holographic interpretations of such matrix models which, by construction, are endowed with a finite dimensional Hilbert space.

  18. MALDI Matrix Research for Biopolymers

    PubMed Central

    Fukuyama, Yuko

    2015-01-01

    Matrices are necessary materials for ionizing analytes in matrix-assisted laser desorption/ionization-mass spectrometry (MALDI-MS). The choice of a matrix appropriate for each analyte controls the analyses. Thus, in some cases, development or improvement of matrices can become a tool for solving problems. This paper reviews MALDI matrix research that the author has conducted in the recent decade. It describes glycopeptide, carbohydrate, or phosphopeptide analyses using 2,5-dihydroxybenzoic acid (2,5-DHB), 1,1,3,3-tetramethylguanidinium (TMG) salts of p-coumaric acid (CA) (G3CA), 3-aminoquinoline (3-AQ)/α-cyano-4-hydroxycinnamic acid (CHCA) (3-AQ/CHCA) or 3-AQ/CA and gengeral peptide, peptide containing disulfide bonds or hydrophobic peptide analyses using butylamine salt of CHCA (CHCAB), 1,5-diaminonaphthalene (1,5-DAN), octyl 2,5-dihydroxybenzoate (alkylated dihydroxybenzoate, ADHB), or 1-(2,4,6-trihydroxyphenyl)octan-1-one (alkylated trihydroxyacetophenone, ATHAP). PMID:26819908

  19. Hybrid matrix amplifier

    DOEpatents

    Martens, J.S.; Hietala, V.M.; Plut, T.A.

    1995-01-03

    The present invention comprises a novel matrix amplifier. The matrix amplifier includes an active superconducting power divider (ASPD) having N output ports; N distributed amplifiers each operatively connected to one of the N output ports of the ASPD; and a power combiner having N input ports each operatively connected to one of the N distributed amplifiers. The distributed amplifier can included M stages of amplification by cascading superconducting active devices. The power combiner can include N active elements. The resulting (N[times]M) matrix amplifier can produce signals of high output power, large bandwidth, and low noise. 6 figures.

  20. Hybrid matrix amplifier

    DOEpatents

    Martens, Jon S.; Hietala, Vincent M.; Plut, Thomas A.

    1995-01-01

    The present invention comprises a novel matrix amplifier. The matrix amplifier includes an active superconducting power divider (ASPD) having N output ports; N distributed amplifiers each operatively connected to one of the N output ports of the ASPD; and a power combiner having N input ports each operatively connected to one of the N distributed amplifiers. The distributed amplifier can included M stages of amplification by cascading superconducting active devices. The power combiner can include N active elements. The resulting (N.times.M) matrix amplifier can produce signals of high output power, large bandwidth, and low noise.

  1. Faces of matrix models

    NASA Astrophysics Data System (ADS)

    Morozov, A.

    2012-08-01

    Partition functions of eigenvalue matrix models possess a number of very different descriptions: as matrix integrals, as solutions to linear and nonlinear equations, as τ-functions of integrable hierarchies and as special-geometry prepotentials, as result of the action of W-operators and of various recursions on elementary input data, as gluing of certain elementary building blocks. All this explains the central role of such matrix models in modern mathematical physics: they provide the basic "special functions" to express the answers and relations between them, and they serve as a dream model of what one should try to achieve in any other field.

  2. Matrix computations on mesh arrays

    SciTech Connect

    Moreno, J.H.

    1989-01-01

    This dissertation addresses the systematic derivation of mesh arrays for matrix computations, in particular realizing the algorithm-specific arrays and mapping algorithms onto class-specific arrays. A data-dependency graph-based transformational method is proposed in a design frame work consisting of two stages, namely algorithm regularization and derivation of arrays. The first stage derives the fully-parallel data-dependency graph (FPG) of an algorithm and transforms this graph into a three-dimensional one with unidirectional nearest-neighbor dependencies (a multi-mesh graph MMG). The second stage transforms the MMG into a two-dimensional G-graph, which is realized as an algorithm-specific array or mapped onto a class-specific array. This stage allows the incorporation of implementation restrictions and the evaluation of tradeoffs in properties of cells, as well as the derivation of arrays for fixed-size data and partitioned problems, while performing optimization of specific performance/cost measures. The proposed method is formalized by presenting a sufficient set of transformations and demonstrating the equivalence of graphs obtained from those transformations. Moreover, it is demonstrated that the MMG representation is always possible, due to the characteristics of the operators. The method has been applied to a collection of matrix algorithms, including matrix multiplication, convolution, matrix decompositions, transitive closure, the Faddeev algorithm, and BBA{sup {minus}1}. The examples show that, in addition to the features listed earlier, this method is easy to apply. Moreover, the method is compared with other techniques, concluding that it is advantageous because it meets evaluation criteria and produces more efficient arrays.

  3. Pesticide-Exposure Matrix

    Cancer.gov

    The "Pesticide-exposure Matrix" was developed to help epidemiologists and other researchers identify the active ingredients to which people were likely exposed when their homes and gardens were treated for pests in past years.

  4. Functional Polymer Matrix Fibers

    DTIC Science & Technology

    2007-11-02

    the carbon nanofibers led to the deterioration of the polymeric cellulose structure. Extensive research on the surface treatment of carbon nanofibers...1 November 2003 - 14-Mar-05 4. TITLE AND SUBTITLE 5a. CONTRACT NUMBER FA8655-03-1-3042 Functional Polymer Matrix Fibres 5b. GRANT NUMBER 5c. PROGRAM...MARYLABONE RD LONDON NWl 5TH PERFORMANCE REPORT Project title: Functional polymer matrix fibers Period of performance: 1 November 2003 - 31 October 2004

  5. Computing Matrix Representations of Filiform Lie Algebras

    NASA Astrophysics Data System (ADS)

    Ceballos, Manuel; Núñez, Juan; Tenorio, Ángel F.

    In this paper, we compute minimal faithful unitriangular matrix representations of filiform Lie algebras. To do it, we use the nilpotent Lie algebra, g_n, formed of n ×n strictly upper-triangular matrices. More concretely, we search the lowest natural number n such that the Lie algebra g_n contains a given filiform Lie algebra, also computing a representative of this algebra. All the computations in this paper have been done using MAPLE 9.5.

  6. Phase diagram of matrix compressed sensing

    NASA Astrophysics Data System (ADS)

    Schülke, Christophe; Schniter, Philip; Zdeborová, Lenka

    2016-12-01

    In the problem of matrix compressed sensing, we aim to recover a low-rank matrix from a few noisy linear measurements. In this contribution, we analyze the asymptotic performance of a Bayes-optimal inference procedure for a model where the matrix to be recovered is a product of random matrices. The results that we obtain using the replica method describe the state evolution of the Parametric Bilinear Generalized Approximate Message Passing (P-BiG-AMP) algorithm, recently introduced in J. T. Parker and P. Schniter [IEEE J. Select. Top. Signal Process. 10, 795 (2016), 10.1109/JSTSP.2016.2539123]. We show the existence of two different types of phase transition and their implications for the solvability of the problem, and we compare the results of our theoretical analysis to the numerical performance reached by P-BiG-AMP. Remarkably, the asymptotic replica equations for matrix compressed sensing are the same as those for a related but formally different problem of matrix factorization.

  7. Generalized matrix inversion is not harder than matrix multiplication

    NASA Astrophysics Data System (ADS)

    Petkovic, Marko D.; Stanimirovic, Predrag S.

    2009-08-01

    Starting from the Strassen method for rapid matrix multiplication and inversion as well as from the recursive Cholesky factorization algorithm, we introduced a completely block recursive algorithm for generalized Cholesky factorization of a given symmetric, positive semi-definite matrix . We used the Strassen method for matrix inversion together with the recursive generalized Cholesky factorization method, and established an algorithm for computing generalized {2,3} and {2,4} inverses. Introduced algorithms are not harder than the matrix-matrix multiplication.

  8. Extracellular matrix structure.

    PubMed

    Theocharis, Achilleas D; Skandalis, Spyros S; Gialeli, Chrysostomi; Karamanos, Nikos K

    2016-02-01

    Extracellular matrix (ECM) is a non-cellular three-dimensional macromolecular network composed of collagens, proteoglycans/glycosaminoglycans, elastin, fibronectin, laminins, and several other glycoproteins. Matrix components bind each other as well as cell adhesion receptors forming a complex network into which cells reside in all tissues and organs. Cell surface receptors transduce signals into cells from ECM, which regulate diverse cellular functions, such as survival, growth, migration, and differentiation, and are vital for maintaining normal homeostasis. ECM is a highly dynamic structural network that continuously undergoes remodeling mediated by several matrix-degrading enzymes during normal and pathological conditions. Deregulation of ECM composition and structure is associated with the development and progression of several pathologic conditions. This article emphasizes in the complex ECM structure as to provide a better understanding of its dynamic structural and functional multipotency. Where relevant, the implication of the various families of ECM macromolecules in health and disease is also presented.

  9. Matrix interdiction problem

    SciTech Connect

    Pan, Feng; Kasiviswanathan, Shiva

    2010-01-01

    In the matrix interdiction problem, a real-valued matrix and an integer k is given. The objective is to remove k columns such that the sum over all rows of the maximum entry in each row is minimized. This combinatorial problem is closely related to bipartite network interdiction problem which can be applied to prioritize the border checkpoints in order to minimize the probability that an adversary can successfully cross the border. After introducing the matrix interdiction problem, we will prove the problem is NP-hard, and even NP-hard to approximate with an additive n{gamma} factor for a fixed constant {gamma}. We also present an algorithm for this problem that achieves a factor of (n-k) mUltiplicative approximation ratio.

  10. Review of "Communication: The Social Matrix of Psychiatry."

    ERIC Educational Resources Information Center

    Sigmon, Scott B.

    "Communication: The Social Matrix of Psychiatry" (J. Ruesch and G. Bateson) is a work that outlines in a more conversational than pedantic way a theory of human communication. The main thrust is to unite two types of organized information: (1) an understanding of the cultural matrix within which the psychiatrist operates; and (2) the nature of…

  11. Matrixed business support comparison study.

    SciTech Connect

    Parsons, Josh D.

    2004-11-01

    The Matrixed Business Support Comparison Study reviewed the current matrixed Chief Financial Officer (CFO) division staff models at Sandia National Laboratories. There were two primary drivers of this analysis: (1) the increasing number of financial staff matrixed to mission customers and (2) the desire to further understand the matrix process and the opportunities and challenges it creates.

  12. Density matrix perturbation theory.

    PubMed

    Niklasson, Anders M N; Challacombe, Matt

    2004-05-14

    An orbital-free quantum perturbation theory is proposed. It gives the response of the density matrix upon variation of the Hamiltonian by quadratically convergent recursions based on perturbed projections. The technique allows treatment of embedded quantum subsystems with a computational cost scaling linearly with the size of the perturbed region, O(N(pert.)), and as O(1) with the total system size. The method allows efficient high order perturbation expansions, as demonstrated with an example involving a 10th order expansion. Density matrix analogs of Wigner's 2n+1 rule are also presented.

  13. Matrix Embedded Organic Synthesis

    NASA Astrophysics Data System (ADS)

    Kamakolanu, U. G.; Freund, F. T.

    2016-05-01

    In the matrix of minerals such as olivine, a redox reaction of the low-z elements occurs. Oxygen is oxidized to the peroxy state while the low-Z-elements become chemically reduced. We assign them a formula [CxHyOzNiSj]n- and call them proto-organics.

  14. Constructing the matrix

    NASA Astrophysics Data System (ADS)

    Elliott, John

    2012-09-01

    As part of our 'toolkit' for analysing an extraterrestrial signal, the facility for calculating structural affinity to known phenomena must be part of our core capabilities. Without such a resource, we risk compromising our potential for detection and decipherment or at least causing significant delay in the process. To create such a repository for assessing structural affinity, all known systems (language parameters) need to be structurally analysed to 'place' their 'system' within a relational communication matrix. This will need to include all known variants of language structure, whether 'living' (in current use) or ancient; this must also include endeavours to incorporate yet undeciphered scripts and non-human communication, to provide as complete a picture as possible. In creating such a relational matrix, post-detection decipherment will be assisted by a structural 'map' that will have the potential for 'placing' an alien communication with its nearest known 'neighbour', to assist subsequent categorisation of basic parameters as a precursor to decipherment. 'Universal' attributes and behavioural characteristics of known communication structure will form a range of templates (Elliott, 2001 [1] and Elliott et al., 2002 [2]), to support and optimise our attempt at categorising and deciphering the content of an extraterrestrial signal. Detection of the hierarchical layers, which comprise intelligent, complex communication, will then form a matrix of calculations that will ultimately score affinity through a relational matrix of structural comparison. In this paper we develop the rationales and demonstrate functionality with initial test results.

  15. Matrix product state renormalization

    NASA Astrophysics Data System (ADS)

    Bal, M.; Rams, M. M.; Zauner, V.; Haegeman, J.; Verstraete, F.

    2016-11-01

    The truncation or compression of the spectrum of Schmidt values is inherent to the matrix product state (MPS) approximation of one-dimensional quantum ground states. We provide a renormalization group picture by interpreting this compression as an application of Wilson's numerical renormalization group along the imaginary time direction appearing in the path integral representation of the state. The location of the physical index is considered as an impurity in the transfer matrix and static MPS correlation functions are reinterpreted as dynamical impurity correlations. Coarse-graining the transfer matrix is performed using a hybrid variational ansatz based on matrix product operators, combining ideas of MPS and the multiscale entanglement renormalization ansatz. Through numerical comparison with conventional MPS algorithms, we explicitly verify the impurity interpretation of MPS compression, as put forward by V. Zauner et al. [New J. Phys. 17, 053002 (2015), 10.1088/1367-2630/17/5/053002] for the transverse-field Ising model. Additionally, we motivate the conceptual usefulness of endowing MPS with an internal layered structure by studying restricted variational subspaces to describe elementary excitations on top of the ground state, which serves to elucidate a transparent renormalization group structure ingrained in MPS descriptions of ground states.

  16. Stable Boron Nitride Interphases for Ceramic Matrix Composites

    NASA Technical Reports Server (NTRS)

    Morscher, Gregory N.

    1999-01-01

    Ceramic matrix composites (CMC's) require strong fibers for good toughness and weak interphases so that cracks which are formed in the matrix debond and deflect around the fibers. If the fibers are strongly bonded to the matrix, CMC's behave like monolithic ceramics (e.g., a ceramic coffee cup), and when subjected to mechanical loads that induce cracking, such CMC's fail catastrophically. Since CMC's are being developed for high temperature corrosive environments such as the combustor liner for advanced High Speed Civil Transport aircraft, the interphases need to be able to withstand the environment when the matrix cracks.

  17. Nanomechanics of the Cartilage Extracellular Matrix

    NASA Astrophysics Data System (ADS)

    Han, Lin; Grodzinsky, Alan J.; Ortiz, Christine

    2011-08-01

    Cartilage is a hydrated biomacromolecular fiber composite located at the ends of long bones that enables proper joint lubrication, articulation, loading, and energy dissipation. Degradation of extracellular matrix molecular components and changes in their nanoscale structure greatly influence the macroscale behavior of the tissue and result in dysfunction with age, injury, and diseases such as osteoarthritis. Here, the application of the field of nanomechanics to cartilage is reviewed. Nanomechanics involves the measurement and prediction of nanoscale forces and displacements, intra- and intermolecular interactions, spatially varying mechanical properties, and other mechanical phenomena existing at small length scales. Experimental nanomechanics and theoretical nanomechanics have been applied to cartilage at varying levels of material complexity, e.g., nanoscale properties of intact tissue, the matrix associated with single cells, biomimetic molecular assemblies, and individual extracellular matrix biomolecules (such as aggrecan, collagen, and hyaluronan). These studies have contributed to establishing a fundamental mechanism-based understanding of native and engineered cartilage tissue function, quality, and pathology.

  18. Hepatocyte Culture in Autologous Decellularized Spleen Matrix

    PubMed Central

    Gao, Rui; Wu, Wanquan; Xiang, Junxi; Lv, Yi; Zheng, Xinglong; Chen, Qian; Wang, Haohua; Wang, Bo; Liu, Zhengwen; Ma, Feng

    2015-01-01

    abstract Background and Aims: Using decellularized scaffold to reengineer liver tissue is a promising alternative therapy for end-stage liver diseases. Though the decellularized human liver matrix is the ideal scaffold for reconstruction of the liver theoretically, the shortage of liver donors is still an obstacle for potential clinical application. Therefore, an appropriate alternative scaffold is needed. In the present study, we used a tissue engineering approach to prepare a rat decellularized spleen matrix (DSM) and evaluate the effectiveness of this DSM for primary rat hepatocytes culture. Methods: Rat decellularized spleen matrix (DSM) was prepared by perfusion of a series of detergents through spleen vasculature. DSM was characterized by residual DNA and specific extracellular matrix distribution. Thereafter, primary rat hepatocytes were cultured in the DSM in a 3-dimensional dynamic culture system, and liver cell survival and biological functions were evaluated by comparison with 3-dimensional sandwich culture and also with cultured in decellularized liver matrix (DLM). Results: Our research found that DSM did not exhibit any cellular components, but preserved the main extracellular matrix and the intact vasculature evaluated by DNA detection, histology, immunohistochemical staining, vessel corrosion cast and upright metallurgical microscope. Moreover, the method of DSM preparation procedure was relatively simple with high success rate (100%). After seeding primary hepatocytes in DSM, the cultured hepatocytes survived inside DSM with albumin synthesis and urea secretion within 10 d. Additionally, hepatocytes in dynamic culture medium had better biological functions at day 10 than that in sandwich culture. Albumin synthesis was 85.67 ± 6.34 μg/107cell/24h in dynamic culture in DSM compared to 62.43 ± 4.59 μg/107cell/24h in sandwich culture (P < 0.01) and to 87.54 ± 5.25 μg/107cell/24h in DLM culture (P > 0.05); urea release was 32.14 ± 8.62 μg

  19. Algebraic construction of the Darboux matrix revisited

    NASA Astrophysics Data System (ADS)

    Cieśliński, Jan L.

    2009-10-01

    We present algebraic construction of Darboux matrices for 1+1-dimensional integrable systems of nonlinear partial differential equations with a special stress on the nonisospectral case. We discuss different approaches to the Darboux-Bäcklund transformation, based on different λ-dependences of the Darboux matrix: polynomial, sum of partial fractions or the transfer matrix form. We derive symmetric N-soliton formulae in the general case. The matrix spectral parameter and dressing actions in loop groups are also discussed. We describe reductions to twisted loop groups, unitary reductions, the matrix Lax pair for the KdV equation and reductions of chiral models (harmonic maps) to SU(n) and to Grassmann spaces. We show that in the KdV case the nilpotent Darboux matrix generates the binary Darboux transformation. The paper is intended as a review of known results (usually presented in a novel context) but some new results are included as well, e.g., general compact formulae for N-soliton surfaces and linear and bilinear constraints on the nonisospectral Lax pair matrices which are preserved by Darboux transformations.

  20. Phylogenetic Stochastic Mapping Without Matrix Exponentiation

    PubMed Central

    Irvahn, Jan; Minin, Vladimir N.

    2014-01-01

    Abstract Phylogenetic stochastic mapping is a method for reconstructing the history of trait changes on a phylogenetic tree relating species/organism carrying the trait. State-of-the-art methods assume that the trait evolves according to a continuous-time Markov chain (CTMC) and works well for small state spaces. The computations slow down considerably for larger state spaces (e.g., space of codons), because current methodology relies on exponentiating CTMC infinitesimal rate matrices—an operation whose computational complexity grows as the size of the CTMC state space cubed. In this work, we introduce a new approach, based on a CTMC technique called uniformization, which does not use matrix exponentiation for phylogenetic stochastic mapping. Our method is based on a new Markov chain Monte Carlo (MCMC) algorithm that targets the distribution of trait histories conditional on the trait data observed at the tips of the tree. The computational complexity of our MCMC method grows as the size of the CTMC state space squared. Moreover, in contrast to competing matrix exponentiation methods, if the rate matrix is sparse, we can leverage this sparsity and increase the computational efficiency of our algorithm further. Using simulated data, we illustrate advantages of our MCMC algorithm and investigate how large the state space needs to be for our method to outperform matrix exponentiation approaches. We show that even on the moderately large state space of codons our MCMC method can be significantly faster than currently used matrix exponentiation methods. PMID:24918812

  1. Advances in biomimetic regeneration of elastic matrix structures

    PubMed Central

    Sivaraman, Balakrishnan; Bashur, Chris A.

    2012-01-01

    Elastin is a vital component of the extracellular matrix, providing soft connective tissues with the property of elastic recoil following deformation and regulating the cellular response via biomechanical transduction to maintain tissue homeostasis. The limited ability of most adult cells to synthesize elastin precursors and assemble them into mature crosslinked structures has hindered the development of functional tissue-engineered constructs that exhibit the structure and biomechanics of normal native elastic tissues in the body. In diseased tissues, the chronic overexpression of proteolytic enzymes can cause significant matrix degradation, to further limit the accumulation and quality (e.g., fiber formation) of newly deposited elastic matrix. This review provides an overview of the role and importance of elastin and elastic matrix in soft tissues, the challenges to elastic matrix generation in vitro and to regenerative elastic matrix repair in vivo, current biomolecular strategies to enhance elastin deposition and matrix assembly, and the need to concurrently inhibit proteolytic matrix disruption for improving the quantity and quality of elastogenesis. The review further presents biomaterial-based options using scaffolds and nanocarriers for spatio-temporal control over the presentation and release of these biomolecules, to enable biomimetic assembly of clinically relevant native elastic matrix-like superstructures. Finally, this review provides an overview of recent advances and prospects for the application of these strategies to regenerating tissue-type specific elastic matrix structures and superstructures. PMID:23355960

  2. Random matrix theory

    NASA Astrophysics Data System (ADS)

    Edelman, Alan; Rao, N. Raj

    Random matrix theory is now a big subject with applications in many disciplines of science, engineering and finance. This article is a survey specifically oriented towards the needs and interests of a numerical analyst. This survey includes some original material not found anywhere else. We include the important mathematics which is a very modern development, as well as the computational software that is transforming the theory into useful practice.

  3. Metal Matrix Composites

    NASA Astrophysics Data System (ADS)

    Mortensen, Andreas; Llorca, Javier

    2010-08-01

    In metal matrix composites, a metal is combined with another, often nonmetallic, phase to produce a novel material having attractive engineering attributes of its own. A subject of much research in the 1980s and 1990s, this class of materials has, in the past decade, increased significantly in variety. Copper matrix composites, layered composites, high-conductivity composites, nanoscale composites, microcellular metals, and bio-derived composites have been added to a palette that, ten years ago, mostly comprised ceramic fiber- or particle-reinforced light metals together with some well-established engineering materials, such as WC-Co cermets. At the same time, research on composites such as particle-reinforced aluminum, aided by novel techniques such as large-cell 3-D finite element simulation or computed X-ray microtomography, has served as a potent vehicle for the elucidation of the mechanics of high-contrast two-phase elastoplastic materials, with implications that range well beyond metal matrix composites.

  4. Role of G protein-coupled receptors (GPCR), matrix metalloproteinases 2 and 9 (MMP2 and MMP9), heparin-binding epidermal growth factor-like growth factor (hbEGF), epidermal growth factor receptor (EGFR), erbB2, and insulin-like growth factor 1 receptor (IGF-1R) in trenbolone acetate-stimulated bovine satellite cell proliferation.

    PubMed

    Thornton, K J; Kamange-Sollo, E; White, M E; Dayton, W R

    2015-09-01

    Implanting cattle with steroids significantly enhances feed efficiency, rate of gain, and muscle growth. However, the mechanisms responsible for these improvements in muscle growth have not been fully elucidated. Trenbolone acetate (TBA), a testosterone analog, has been shown to increase proliferation rate in bovine satellite cell (BSC) cultures. The classical genomic actions of testosterone have been well characterized; however, our results indicate that TBA may also initiate a quicker, nongenomic response that involves activation of G protein-coupled receptors (GPCR) resulting in activation of matrix metalloproteinases 2 and 9 (MMP2 and MMP9) that release membrane-bound heparin-binding epidermal growth factor-like growth factor (hbEGF), which then binds to and activates the epidermal growth factor receptor (EGFR) and/or erbB2. Furthermore, the EGFR has been shown to regulate expression of the IGF-1 receptor (IGF-1R), which is well known for its role in modulating muscle growth. To determine whether this nongenomic pathway is potentially involved in TBA-stimulated BSC proliferation, we analyzed the effects of treating BSC with guanosine 5'-O-2-thiodiphosphate (GDPβS), an inhibitor of all GPCR; a MMP2 and MMP9 inhibitor (MMPI); CRM19, a specific inhibitor of hbEGF; AG1478, a specific EGFR tyrosine kinase inhibitor; AG879, a specific erbB2 kinase inhibitor; and AG1024, an IGF-1R tyrosine kinase inhibitor on TBA-stimulated proliferation rate (H-thymidine incorporation). Assays were replicated at least 9 times for each inhibitor experiment using BSC cultures obtained from at least 3 different animals. Bovine satellite cell cultures were obtained from yearling steers that had no previous exposure to androgenic or estrogenic compounds. As expected, BSC cultures treated with 10 n TBA showed ( < 0.05) increased proliferation rate when compared with control cultures. Additionally, treatment with 5 ng hbEGF/mL stimulated proliferation in BSC cultures ( < 0.05). Treatment

  5. On the Matrix Exponential Function

    ERIC Educational Resources Information Center

    Hou, Shui-Hung; Hou, Edwin; Pang, Wan-Kai

    2006-01-01

    A novel and simple formula for computing the matrix exponential function is presented. Specifically, it can be used to derive explicit formulas for the matrix exponential of a general matrix A satisfying p(A) = 0 for a polynomial p(s). It is ready for use in a classroom and suitable for both hand as well as symbolic computation.

  6. The cellulose resource matrix.

    PubMed

    Keijsers, Edwin R P; Yılmaz, Gülden; van Dam, Jan E G

    2013-03-01

    The emerging biobased economy is causing shifts from mineral fossil oil based resources towards renewable resources. Because of market mechanisms, current and new industries utilising renewable commodities, will attempt to secure their supply of resources. Cellulose is among these commodities, where large scale competition can be expected and already is observed for the traditional industries such as the paper industry. Cellulose and lignocellulosic raw materials (like wood and non-wood fibre crops) are being utilised in many industrial sectors. Due to the initiated transition towards biobased economy, these raw materials are intensively investigated also for new applications such as 2nd generation biofuels and 'green' chemicals and materials production (Clark, 2007; Lange, 2007; Petrus & Noordermeer, 2006; Ragauskas et al., 2006; Regalbuto, 2009). As lignocellulosic raw materials are available in variable quantities and qualities, unnecessary competition can be avoided via the choice of suitable raw materials for a target application. For example, utilisation of cellulose as carbohydrate source for ethanol production (Kabir Kazi et al., 2010) avoids the discussed competition with easier digestible carbohydrates (sugars, starch) deprived from the food supply chain. Also for cellulose use as a biopolymer several different competing markets can be distinguished. It is clear that these applications and markets will be influenced by large volume shifts. The world will have to reckon with the increase of competition and feedstock shortage (land use/biodiversity) (van Dam, de Klerk-Engels, Struik, & Rabbinge, 2005). It is of interest - in the context of sustainable development of the bioeconomy - to categorize the already available and emerging lignocellulosic resources in a matrix structure. When composing such "cellulose resource matrix" attention should be given to the quality aspects as well as to the available quantities and practical possibilities of processing the

  7. Supported Molecular Matrix Electrophoresis.

    PubMed

    Matsuno, Yu-Ki; Kameyama, Akihiko

    2015-01-01

    Mucins are difficult to separate using conventional gel electrophoresis methods such as SDS-PAGE and agarose gel electrophoresis, owing to their large size and heterogeneity. On the other hand, cellulose acetate membrane electrophoresis can separate these molecules, but is not compatible with glycan analysis. Here, we describe a novel membrane electrophoresis technique, termed "supported molecular matrix electrophoresis" (SMME), in which a porous polyvinylidene difluoride (PVDF) membrane filter is used to achieve separation. This description includes the separation, visualization, and glycan analysis of mucins with the SMME technique.

  8. Statistical meaning of the differential Mueller matrix of depolarizing homogeneous media.

    PubMed

    Ossikovski, Razvigor; Arteaga, Oriol

    2014-08-01

    By applying the statistical definition of a depolarizing Mueller matrix we formally derive and physically interpret the differential matrix of a depolarizing homogeneous medium. The depolarization phenomenon being a direct consequence of the fluctuations of the six elementary polarization properties of the medium, the differential matrix contains the mean values and the variances of the properties, thus fully describing those from a statistical viewpoint. Similarly, the reduced coherency matrix associated with the G-symmetric component of the differential matrix has an immediate physical interpretation as being the covariance matrix of the three basic groups of polarization properties. The formal developments are illustrated on experimental examples.

  9. Ceramic matrix and resin matrix composites: A comparison

    NASA Technical Reports Server (NTRS)

    Hurwitz, Frances I.

    1987-01-01

    The underlying theory of continuous fiber reinforcement of ceramic matrix and resin matrix composites, their fabrication, microstructure, physical and mechanical properties are contrasted. The growing use of organometallic polymers as precursors to ceramic matrices is discussed as a means of providing low temperature processing capability without the fiber degradation encountered with more conventional ceramic processing techniques. Examples of ceramic matrix composites derived from particulate-filled, high char yield polymers and silsesquioxane precursors are provided.

  10. Mixed Mode Matrix Multiplication

    SciTech Connect

    Meng-Shiou Wu; Srinivas Aluru; Ricky A. Kendall

    2004-09-30

    In modern clustering environments where the memory hierarchy has many layers (distributed memory, shared memory layer, cache,...), an important question is how to fully utilize all available resources and identify the most dominant layer in certain computations. When combining algorithms on all layers together, what would be the best method to get the best performance out of all the resources we have? Mixed mode programming model that uses thread programming on the shared memory layer and message passing programming on the distributed memory layer is a method that many researchers are using to utilize the memory resources. In this paper, they take an algorithmic approach that uses matrix multiplication as a tool to show how cache algorithms affect the performance of both shared memory and distributed memory algorithms. They show that with good underlying cache algorithm, overall performance is stable. When underlying cache algorithm is bad, superlinear speedup may occur, and an increasing number of threads may also improve performance.

  11. Matrix membranes and integrability

    SciTech Connect

    Zachos, C.; Fairlie, D.; Curtright, T.

    1997-06-01

    This is a pedagogical digest of results reported in Curtright, Fairlie, {ampersand} Zachos 1997, and an explicit implementation of Euler`s construction for the solution of the Poisson Bracket dual Nahm equation. But it does not cover 9 and 10-dimensional systems, and subsequent progress on them Fairlie 1997. Cubic interactions are considered in 3 and 7 space dimensions, respectively, for bosonic membranes in Poisson Bracket form. Their symmetries and vacuum configurations are explored. Their associated first order equations are transformed to Nahm`s equations, and are hence seen to be integrable, for the 3-dimensional case, by virtue of the explicit Lax pair provided. Most constructions introduced also apply to matrix commutator or Moyal Bracket analogs.

  12. Hyaluronan: A Matrix Component

    NASA Astrophysics Data System (ADS)

    Rügheimer, Louise

    2008-09-01

    The glucosaminoglycan hyaluronan is a key component of the extracellular matrix. It is a large, negatively charged molecule that can act as an ion exchange reservoir for positive ions. Hyaluronan is involved in renomedullary water handling through its water-binding capacity. In the renal medulla, the main source for hyaluronan production is the renomedullary interstitial cells. Hyaluronan synthases are found in the inner part of the plasma membrane and polymerize hyaluronan chains which are extruded into the extracellular space. Hyaluronidases are a family of enzymes involved in the degradation of hyaluronan. They have a wide range of properties, including differences in size, inhibitor sensitivities, catalytic mechanisms, substrate specificities and pH optima.

  13. Light cone matrix product

    SciTech Connect

    Hastings, Matthew B

    2009-01-01

    We show how to combine the light-cone and matrix product algorithms to simulate quantum systems far from equilibrium for long times. For the case of the XXZ spin chain at {Delta} = 0.5, we simulate to a time of {approx} 22.5. While part of the long simulation time is due to the use of the light-cone method, we also describe a modification of the infinite time-evolving bond decimation algorithm with improved numerical stability, and we describe how to incorporate symmetry into this algorithm. While statistical sampling error means that we are not yet able to make a definite statement, the behavior of the simulation at long times indicates the appearance of either 'revivals' in the order parameter as predicted by Hastings and Levitov (e-print arXiv:0806.4283) or of a distinct shoulder in the decay of the order parameter.

  14. Calculation of the heavy-hadron axial couplings g1, g2, and g3 using lattice QCD

    SciTech Connect

    Will Detmold, David Lin, Stefan Meinel

    2012-06-01

    In a recent paper [arXiv:1109.2480] we have reported on a lattice QCD calculation of the heavy-hadron axial couplings g{sub 1}, g{sub 2}, and g{sub 3}. These quantities are low-energy constants of heavy-hadron chiral perturbation theory (HH{chi}PT) and are related to the B*B{pi}, {Sigma}{sub b}*{Sigma}{sub b}{pi}, and {Sigma}{sub b}{sup (*)}{Lambda}{sub b}{pi} couplings. In the following, we discuss important details of the calculation and give further results. To determine the axial couplings, we explicitly match the matrix elements of the axial current in QCD with the corresponding matrix elements in HH{chi}PT. We construct the ratios of correlation functions used to calculate the matrix elements in lattice QCD, and study the contributions from excited states. We present the complete numerical results and discuss the data analysis in depth. In particular, we demonstrate the convergence of SU(4|2) HH{chi}PT for the axial current matrix elements at pion masses up to about 400 MeV and show the impact of the nonanalytic loop contributions. Finally, we present additional predictions for strong and radiative decay widths of charm and bottom baryons.

  15. Excited State Effects in Nucleon Matrix Element Calculations

    SciTech Connect

    Constantia Alexandrou, Martha Constantinou, Simon Dinter, Vincent Drach, Karl Jansen, Theodoros Leontiou, Dru B Renner

    2011-12-01

    We perform a high-statistics precision calculation of nucleon matrix elements using an open sink method allowing us to explore a wide range of sink-source time separations. In this way the influence of excited states of nucleon matrix elements can be studied. As particular examples we present results for the nucleon axial charge g{sub A} and for the first moment of the isovector unpolarized parton distribution x{sub u-d}. In addition, we report on preliminary results using the generalized eigenvalue method for nucleon matrix elements. All calculations are performed using N{sub f} = 2+1+1 maximally twisted mass Wilson fermions.

  16. Lectures on Matrix Field Theory

    NASA Astrophysics Data System (ADS)

    Ydri, Badis

    The subject of matrix field theory involves matrix models, noncommutative geometry, fuzzy physics and noncommutative field theory and their interplay. In these lectures, a lot of emphasis is placed on the matrix formulation of noncommutative and fuzzy spaces, and on the non-perturbative treatment of the corresponding field theories. In particular, the phase structure of noncommutative $\\phi^4$ theory is treated in great detail, and an introduction to noncommutative gauge theory is given.

  17. Analytical techniques for instrument design - matrix methods

    SciTech Connect

    Robinson, R.A.

    1997-09-01

    We take the traditional Cooper-Nathans approach, as has been applied for many years for steady-state triple-axis spectrometers, and consider its generalisation to other inelastic scattering spectrometers. This involves a number of simple manipulations of exponentials of quadratic forms. In particular, we discuss a toolbox of matrix manipulations that can be performed on the 6- dimensional Cooper-Nathans matrix: diagonalisation (Moller-Nielsen method), coordinate changes e.g. from ({Delta}k{sub I},{Delta}k{sub F} to {Delta}E, {Delta}Q & 2 dummy variables), integration of one or more variables (e.g. over such dummy variables), integration subject to linear constraints (e.g. Bragg`s Law for analysers), inversion to give the variance-covariance matrix, and so on. We show how these tools can be combined to solve a number of important problems, within the narrow-band limit and the gaussian approximation. We will argue that a generalised program that can handle multiple different spectrometers could (and should) be written in parallel to the Monte-Carlo packages that are becoming available. We will also discuss the complementarity between detailed Monte-Carlo calculations and the approach presented here. In particular, Monte-Carlo methods traditionally simulate the real experiment as performed in practice, given a model scattering law, while the Cooper-Nathans method asks the inverse question: given that a neutron turns up in a particular spectrometer configuration (e.g. angle and time of flight), what is the probability distribution of possible scattering events at the sample? The Monte-Carlo approach could be applied in the same spirit to this question.

  18. Studying genetic code by a matrix approach.

    PubMed

    Crowder, Tanner; Li, Chi-Kwong

    2010-05-01

    Following Petoukhov and his collaborators, we use two length n zero-one sequences, alpha and beta, to represent a length n genetic sequence (alpha/beta) so that the columns of (alpha/beta) have the following correspondence with the nucleotides: C ~ (0/0), U ~ (1/0), G ~ (1/1), A ~ (0/1). Using the Gray code ordering to arrange alpha and beta, we build a 2(n) x 2(n) matrix C(n) including all the 4(n) length n genetic sequences. Furthermore, we use the Hamming distance of alpha and beta to construct a 2(n) x 2(n) matrix D(n). We explore structures of these matrices, refine the results in earlier papers, and propose new directions for further research.

  19. Matrix market: a web resource for test matrix collection

    SciTech Connect

    Boisvert, R.F.; Pozo, R.; Remington, K.; Barrett, R.F.; Dongarra, J.J. /

    1996-05-30

    We describe a repository of data for the testing of numerical algorithms and mathematical software for matrix computations. The repository is designed to accommodate both dense and sparse matrices, as well as software to generate matrices. It has been seeded with the well known Harwell-Boeing sparse matrix collection. The raw data files have been augmented with an integrated World Wide Web interface which describes the matrices in the collection quantitatively and visually, For example, each matrix has a Web page which details its attributes, graphically depicts its sparsity pattern, and provides access to the matrix itself in several formats. In addition, a search mechanism is included which allows retrieval of matrices based on a variety of attributes, such as type and size, as well as through free-text search in abstracts. The URL is http://math.nist.gov/MatrixMarket.

  20. Ceramic matrix composite article and process of fabricating a ceramic matrix composite article

    SciTech Connect

    Cairo, Ronald Robert; DiMascio, Paul Stephen; Parolini, Jason Robert

    2016-01-12

    A ceramic matrix composite article and a process of fabricating a ceramic matrix composite are disclosed. The ceramic matrix composite article includes a matrix distribution pattern formed by a manifold and ceramic matrix composite plies laid up on the matrix distribution pattern, includes the manifold, or a combination thereof. The manifold includes one or more matrix distribution channels operably connected to a delivery interface, the delivery interface configured for providing matrix material to one or more of the ceramic matrix composite plies. The process includes providing the manifold, forming the matrix distribution pattern by transporting the matrix material through the manifold, and contacting the ceramic matrix composite plies with the matrix material.

  1. Hybridized polymer matrix composites

    NASA Technical Reports Server (NTRS)

    House, E. E.; Hoggatt, J. T.; Symonds, W. A.

    1980-01-01

    The extent to which graphite fibers are released from resin matrix composites that are exposed to fire and impact conditions was determined. Laboratory simulations of those conditions that could exist in the event of an aircraft crash and burn situation were evaluated. The effectiveness of various hybridizing concepts in preventing this release of graphite fibers were also evaluated. The baseline (i.e., unhybridized) laminates examined were prepared from commercially available graphite/epoxy, graphite/polyimide, and graphite/phenolic materials. Hybridizing concepts investigated included resin fillers, laminate coatings, resin blending, and mechanical interlocking of the graphite reinforcement. The baseline and hybridized laminates' mechanical properties, before and after isothermal and humidity aging, were also compared. It was found that a small amount of graphite fiber was released from the graphite/epoxy laminates during the burn and impact conditions used in this program. However, the extent to which the fibers were released is not considered a severe enough problem to preclude the use of graphite reinforced composites in civil aircraft structure. It also was found that several hybrid concepts eliminated this fiber release. Isothermal and humidity aging did not appear to alter the fiber release tendencies.

  2. Glass matrix armor

    DOEpatents

    Calkins, Noel C.

    1991-01-01

    An armor system which utilizes glass. A plurality of constraint cells are mounted on a surface of a substrate, which is metal armor plate or a similar tough material, such that the cells almost completely cover the surface of the substrate. Each constraint cell has a projectile-receiving wall parallel to the substrate surface and has sides which are perpendicular to and surround the perimeter of the receiving wall. The cells are mounted such that, in one embodiment, the substrate surface serves as a sixth side or closure for each cell. Each cell has inside of it a plate, termed the front plate, which is parallel to and in contact with substantially all of the inside surface of the receiving wall. The balance of each cell is completely filled with a projectile-abrading material consisting of glass and a ceramic material and, in certain embodiments, a polymeric material. The glass may be in monolithic form or particles of ceramic may be dispersed in a glass matrix. The ceramic material may be in monolithic form or may be in the form of particles dispersed in glass or dispersed in said polymer.

  3. How to Study a Matrix

    ERIC Educational Resources Information Center

    Jairam, Dharmananda; Kiewra, Kenneth A.; Kauffman, Douglas F.; Zhao, Ruomeng

    2012-01-01

    This study investigated how best to study a matrix. Fifty-three participants studied a matrix topically (1 column at a time), categorically (1 row at a time), or in a unified way (all at once). Results revealed that categorical and unified study produced higher: (a) performance on relationship and fact tests, (b) study material satisfaction, and…

  4. Matrix Methods to Analytic Geometry.

    ERIC Educational Resources Information Center

    Bandy, C.

    1982-01-01

    The use of basis matrix methods to rotate axes is detailed. It is felt that persons who have need to rotate axes often will find that the matrix method saves considerable work. One drawback is that most students first learning to rotate axes will not yet have studied linear algebra. (MP)

  5. Optical Coherency Matrix Tomography

    DTIC Science & Technology

    2015-10-19

    multipartite quantum states in quantum information science. Here G is reconstructed from a minimal set of linearly independent measurements, each a cascade of...spatial-mode characterization16. In exploring these settings, it has recently proven fruitful to adopt the Hilbert-space formulation used in quantum ...multiple DoFs, such a treatment necessitates introducing the notion of ‘classical entanglement’10,19–25. In quantum mechanics, states associated with

  6. Micromechanics for ceramic matrix composites

    NASA Technical Reports Server (NTRS)

    Murthy, P. L. N.; Chamis, C. C.

    1991-01-01

    The fiber substructuring concepts and the micromechanics equations that are embedded in the Ceramic Matrix Composite Analyzer (CEMCAN) computer code are described as well as the code itself, its current features and capabilities, and some examples to demonstrate the code's versatility. The methodology is equally applicable to metal matrix and polymer matrix composites. The prediction of ply mechanical and thermal properties agree very well with the existing models in the Integrated Composite Analyzer and the Ceramic Matrix Composite Analyzer, lending credence to the fiber substructuring approach. Fiber substructuring can capture greater local detail than conventional unit-cell-based micromechanical theories. It offers promise in simulating complex aspects of micromechanics in ceramic matrix composites.

  7. Making recombinant extracellular matrix proteins.

    PubMed

    Ruggiero, Florence; Koch, Manuel

    2008-05-01

    A variety of approaches to understand extracellular matrix protein structure and function require production of recombinant proteins. Moreover, the expression of heterologous extracellular matrix proteins, in particular collagens, using the recombinant technology is of major interest to the biomedical industry. Although extracellular matrix proteins are large, modular and often multimeric, most of them have been successfully produced in various expression systems. This review provides important factors, including the design of the construct, the cloning strategies, the expression vectors, the transfection method and the host cell systems, to consider in choosing a reliable and cost-effective way to make recombinant extracellular matrix proteins. Advantages and drawbacks of each system have been appraised. Protocols that may ease efficient recombinant production of extracellular matrix are described. Emphasis is placed on the recombinant collagen production. Members of the collagen superfamily exhibit specific structural features and generally require complex post-translational modifications to retain full biological activity that make more arduous their recombinant production.

  8. New Chorus Diffusion Matrix

    NASA Astrophysics Data System (ADS)

    Horne, Richard B.; Kersten, Tobias; Glauert, Sarah A.; Meredith, Nigel P.; Boscher, Daniel; Sicard, Angelica; Maget, Vincent

    2013-04-01

    Whistler mode chorus waves play a major role in the loss and acceleration of electrons in the Earth's radiation belts. While high time resolution satellite data show that these waves are highly structured in frequency and time, at present their effects on the electron distribution can only be assessed on a global scale by using quasi-linear diffusion theory. Here we present new quasi-linear diffusion coefficients for upper and lower band chorus waves for use in global radiation belt models. Using data from DE 1 CRRES, Cluster 1, Double Star TC1 and THEMIS, we have constructed a database of wave properties and used this to construct new diffusion coefficients for L* = 1.5 to 10 in steps of 0.5, 10 latitude bins between 0o and 60o ,8 bins in MLT and 5 levels of geomagnetic activity as measured by Kp. We find that the peak frequency of lower band chorus is close to 0.2 fce, which is lower than that used in previous models. The combined upper and lower band chorus diffusion shows structure that should result in an energy dependent pitch angle anisotropy, particularly between 1 keV and 100 keV. The diffusion rates suggest that wave-particle interactions should still be very important outside geostationary orbit, out to at least L* = 8. We find significant energy diffusion near 1 keV near the loss cone, consistent with wave growth. By including the new chorus diffusion matrix into the BAS radiation belt (BRB) model we compare the effects on the evolution of the radiation belts against previous models.

  9. Nano- and mesoscale modeling of cement matrix

    NASA Astrophysics Data System (ADS)

    Yu, Zechuan; Lau, Denvid

    2015-04-01

    Atomistic simulations of cementitious material can enrich our understanding of its structural and mechanical properties, whereas current computational capacities restrict the investigation length scale within 10 nm. In this context, coarse-grained simulations can translate the information from nanoscale to mesoscale, thus bridging the multi-scale investigations. Here, we develop a coarse-grained model of cement matrix using the concept of disk-like building block. The objective is to introduce a new method to construct a coarse-grained model of cement, which could contribute to the scale-bridging issue from nanoscale to mesoscale. PAC codes: 07.05.Tp, 62.25.-g, 82.70.Dd

  10. Nano- and mesoscale modeling of cement matrix.

    PubMed

    Yu, Zechuan; Lau, Denvid

    2015-01-01

    Atomistic simulations of cementitious material can enrich our understanding of its structural and mechanical properties, whereas current computational capacities restrict the investigation length scale within 10 nm. In this context, coarse-grained simulations can translate the information from nanoscale to mesoscale, thus bridging the multi-scale investigations. Here, we develop a coarse-grained model of cement matrix using the concept of disk-like building block. The objective is to introduce a new method to construct a coarse-grained model of cement, which could contribute to the scale-bridging issue from nanoscale to mesoscale. PAC codes: 07.05.Tp, 62.25.-g, 82.70.Dd.

  11. Rapid divergence of genetic variance-covariance matrix within a natural population.

    PubMed

    Doroszuk, Agnieszka; Wojewodzic, Marcin W; Gort, Gerrit; Kammenga, Jan E

    2008-03-01

    The matrix of genetic variances and covariances (G matrix) represents the genetic architecture of multiple traits sharing developmental and genetic processes and is central for predicting phenotypic evolution. These predictions require that the G matrix be stable. Yet the timescale and conditions promoting G matrix stability in natural populations remain unclear. We studied stability of the G matrix in a 20-year evolution field experiment, where a population of the cosmopolitan parthenogenetic soil nematode Acrobeloides nanus was subjected to drift and divergent selection (benign and stress environments). Selection regime did not influence the level of absolute genetic constraints: under both regimes, two genetic dimensions for three life-history traits were identified. A substantial response to selection in principal components structure and in general matrix pattern was indicated by three statistical methods. G structure was also influenced by drift, with higher divergence under benign conditions. These results show that the G matrix might evolve rapidly in natural populations. The observed high dynamics of G structure probably represents the general feature of asexual species and limits the predictive power of G in phenotypic evolution analyses.

  12. Properties of five toughened matrix composite materials

    NASA Technical Reports Server (NTRS)

    Cano, Roberto J.; Dow, Marvin B.

    1992-01-01

    The use of toughened matrix composite materials offers an attractive solution to the problem of poor damage tolerance associated with advanced composite materials. In this study, the unidirectional laminate strengths and moduli, notched (open-hole) and unnotched tension and compression properties of quasi-isotropic laminates, and compression-after-impact strengths of five carbon fiber/toughened matrix composites, IM7/E7T1-2, IM7/X1845, G40-800X/5255-3, IM7/5255-3, and IM7/5260 have been evaluated. The compression-after-impact (CAI) strengths were determined primarily by impacting quasi-isotropic laminates with the NASA Langley air gun. A few CAI tests were also made with a drop-weight impactor. For a given impact energy, compression after impact strengths were determined to be dependent on impactor velocity. Properties and strengths for the five materials tested are compared with NASA data on other toughened matrix materials (IM7/8551-7, IM6/1808I, IM7/F655, and T800/F3900). This investigation found that all five materials were stronger and more impact damage tolerant than more brittle carbon/epoxy composite materials currently used in aircraft structures.

  13. The matrix of inspiration

    NASA Astrophysics Data System (ADS)

    Oehlmann, Dietmar; Ohlmann, Odile M.; Danzebrink, Hans U.

    2005-04-01

    perform this exchange, as a matrix, understood as source, of new ideas.

  14. Controlled release evaluation of bacterial fertilizer using polymer composites as matrix.

    PubMed

    Wu, Chin-San

    2008-11-24

    The use of polybutylene succinate (PBSU)/starch-type composite as biodegradable matrix material for the controlled release of bacterial fertilizer was evaluated. The composites were prepared by a melting-blending method and various methods/instruments were applied to characterize composites and PBSU. The mechanical properties of the PBSU/starch composite were worse than PBSU alone because the former had poor compatibility between starch and the polymer matrix. Much better dispersion and homogeneity were observed in the composite when PBSU was replaced by acrylic acid grafted PBSU (PBSU-g-AA), hence leading to better mechanical properties of PBSU-g-AA/starch. Furthermore, PBSU-g-AA/starch was more easily processed. The bacterial fertilizer was encapsulated in PBSU and PBSU-g-AA/starch matrix. Increased blending of starch increased the biodegradability of matrix and the amount and rate of cell release from matrix suggesting that this composite is a promising candidate material for 'controlled release' bacterial fertilizer.

  15. Matrix cracking in brittle-matrix composites with tailored interfaces

    SciTech Connect

    Danchaivijit, S.; Chao, L.Y.; Shetty, D.K.

    1995-10-01

    Matrix cracking from controlled through cracks with bridging filaments was studied in a model unidirectional composite of SiC filaments in an epoxy-bonded alumina matrix. An unbonded, frictional interface was produced by moderating the curing shrinkage of the epoxy with the alumina filler and coating the filaments with a releasing agent. Uniaxial tension test specimens (2.5 x 25 x 125 mm) with filament-bridged through cracks were fabricated by a novel two-step casting technique involving casting, precracking and joining of cracked and uncracked sections. Distinct matrix-cracking stresses, corresponding to the extension of the filament-bridged cracks, were measured in uniaxial tension tests using a high-sensitivity extensometer. The crack-length dependence of the matrix-cracking stress was found to be in good agreement with the prediction of a fracture-mechanics analysis that employed a new crack-closure force-crack-opening displacement relation in the calculation of the stress intensity for fiber-bridged cracks. The prediction was based on independent experimental measurements of the matrix fracture toughness (K{sub cm}), the interfacial sliding friction stress ({tau}) and the residual stress in the matrix ({sigma}{sub m}{sup I}). The matrix-cracking stress for crack lengths (2a) greater than 3 mm was independent of the crack length and agreed with the prediction of the steady-state theory of Budiansky, Hutchinson and Evans. Tests on specimens without the deliberately introduced cracks indicated a matrix-cracking stress significantly higher than the steady-state stress.

  16. New pole placement algorithm - Polynomial matrix approach

    NASA Technical Reports Server (NTRS)

    Shafai, B.; Keel, L. H.

    1990-01-01

    A simple and direct pole-placement algorithm is introduced for dynamical systems having a block companion matrix A. The algorithm utilizes well-established properties of matrix polynomials. Pole placement is achieved by appropriately assigning coefficient matrices of the corresponding matrix polynomial. This involves only matrix additions and multiplications without requiring matrix inversion. A numerical example is given for the purpose of illustration.

  17. Matrix Fourth-Complex Variables

    NASA Astrophysics Data System (ADS)

    Dimiev, Stancho; Marinov, Marin S.; Stoev, Peter

    2009-11-01

    In the paper we consider quasi-cyclic hyper-complex variables which are naturally related to the partial differential equations with complex variables. In fact, we develop a matrix 4×4 generalization of the classical bicomplex numbers [1], [2]. We recall that a matrix 2×2 isomorphic type treatment of the classical bicomplex numbers was developed in [3]. Here we develop a matrix 4×4 generalization of the bicomplex numbers including some improvement of the papers [3] and [4]. Let us remark that a deep generalization of the considered ideas was sketch in [5] before us.

  18. Mechanotransduction and extracellular matrix homeostasis

    PubMed Central

    Humphrey, Jay D.; Dufresne, Eric R.; Schwartz, Martin A.

    2015-01-01

    Preface Soft connective tissues at steady state are yet dynamic; resident cells continually read environmental cues and respond to promote homeostasis, including maintenance of the mechanical properties of the extracellular matrix that are fundamental to cellular and tissue health. The mechanosensing process involves assessment of the mechanics of the matrix by the cells through integrins and the actomyosin cytoskeleton, and is followed by a mechano-regulation process that includes the deposition, rearrangement, or removal of matrix to maintain overall form and function. Progress toward understanding the molecular, cellular, and tissue scale effects that promote mechanical homeostasis has helped identify key questions for future research. PMID:25355505

  19. Genotype imputation via matrix completion

    PubMed Central

    Chi, Eric C.; Zhou, Hua; Chen, Gary K.; Del Vecchyo, Diego Ortega; Lange, Kenneth

    2013-01-01

    Most current genotype imputation methods are model-based and computationally intensive, taking days to impute one chromosome pair on 1000 people. We describe an efficient genotype imputation method based on matrix completion. Our matrix completion method is implemented in MATLAB and tested on real data from HapMap 3, simulated pedigree data, and simulated low-coverage sequencing data derived from the 1000 Genomes Project. Compared with leading imputation programs, the matrix completion algorithm embodied in our program MENDEL-IMPUTE achieves comparable imputation accuracy while reducing run times significantly. Implementation in a lower-level language such as Fortran or C is apt to further improve computational efficiency. PMID:23233546

  20. High temperature polymer matrix composites

    NASA Technical Reports Server (NTRS)

    Serafini, Tito T. (Editor)

    1987-01-01

    These are the proceedings of the High Temperature Polymer Matrix Composites Conference held at the NASA Lewis Research Center on March 16 to 18, 1983. The purpose of the conference is to provide scientists and engineers working in the field of high temperature polymer matrix composites an opportunity to review, exchange, and assess the latest developments in this rapidly expanding area of materials technology. Technical papers are presented in the following areas: (1) matrix development; (2) adhesive development; (3) Characterization; (4) environmental effects; and (5) applications.

  1. High Temperature Polymer Matrix Composites

    NASA Technical Reports Server (NTRS)

    1985-01-01

    These are the proceedings of the High Temperature Polymer Matrix Composites Conference held at the NASA Lewis Research Center on March 16 to 18, 1983. The purpose of the conference is to provide scientists and engineers working in the field of high temperature polymer matrix composites an opportunity to review, exchange, and assess the latest developments in this rapidly expanding area of materials technology. Technical papers are presented in the following areas: (1) matrix development; (2) adhesive development; (3) characterization; (4) environmental effects; and (5) applications.

  2. Matrix product operators, matrix product states, and ab initio density matrix renormalization group algorithms.

    PubMed

    Chan, Garnet Kin-Lic; Keselman, Anna; Nakatani, Naoki; Li, Zhendong; White, Steven R

    2016-07-07

    Current descriptions of the ab initio density matrix renormalization group (DMRG) algorithm use two superficially different languages: an older language of the renormalization group and renormalized operators, and a more recent language of matrix product states and matrix product operators. The same algorithm can appear dramatically different when written in the two different vocabularies. In this work, we carefully describe the translation between the two languages in several contexts. First, we describe how to efficiently implement the ab initio DMRG sweep using a matrix product operator based code, and the equivalence to the original renormalized operator implementation. Next we describe how to implement the general matrix product operator/matrix product state algebra within a pure renormalized operator-based DMRG code. Finally, we discuss two improvements of the ab initio DMRG sweep algorithm motivated by matrix product operator language: Hamiltonian compression, and a sum over operators representation that allows for perfect computational parallelism. The connections and correspondences described here serve to link the future developments with the past and are important in the efficient implementation of continuing advances in ab initio DMRG and related algorithms.

  3. Matrix product operators, matrix product states, and ab initio density matrix renormalization group algorithms

    NASA Astrophysics Data System (ADS)

    Chan, Garnet Kin-Lic; Keselman, Anna; Nakatani, Naoki; Li, Zhendong; White, Steven R.

    2016-07-01

    Current descriptions of the ab initio density matrix renormalization group (DMRG) algorithm use two superficially different languages: an older language of the renormalization group and renormalized operators, and a more recent language of matrix product states and matrix product operators. The same algorithm can appear dramatically different when written in the two different vocabularies. In this work, we carefully describe the translation between the two languages in several contexts. First, we describe how to efficiently implement the ab initio DMRG sweep using a matrix product operator based code, and the equivalence to the original renormalized operator implementation. Next we describe how to implement the general matrix product operator/matrix product state algebra within a pure renormalized operator-based DMRG code. Finally, we discuss two improvements of the ab initio DMRG sweep algorithm motivated by matrix product operator language: Hamiltonian compression, and a sum over operators representation that allows for perfect computational parallelism. The connections and correspondences described here serve to link the future developments with the past and are important in the efficient implementation of continuing advances in ab initio DMRG and related algorithms.

  4. Extracellular matrix and wound healing.

    PubMed

    Maquart, F X; Monboisse, J C

    2014-04-01

    Extracellular matrix has been known for a long time as an architectural support for the tissues. Many recent data, however, have shown that extracellular matrix macromolecules (collagens, elastin, glycosaminoglycans, proteoglycans and connective tissue glycoproteins) are able to regulate many important cell functions, such as proliferation, migration, protein synthesis or degradation, apoptosis, etc., making them able to play an important role in the wound repair process. Not only the intact macromolecules but some of their specific domains, that we called "Matrikines", are also able to regulate many cell activities. In this article, we will summarize main findings showing the effects of extracellular matrix macromolecules and matrikines on connective tissue and epithelial cells, particularly in skin, and their potential implication in the wound healing process. These examples show that extracellular matrix macromolecules or some of their specific domains may play a major role in wound healing. Better knowledge of these interactions may suggest new therapeutic targets in wound healing defects.

  5. Matrix quantum mechanics from qubits

    NASA Astrophysics Data System (ADS)

    Hartnoll, Sean A.; Huijse, Liza; Mazenc, Edward A.

    2017-01-01

    We introduce a transverse field Ising model with order N 2 spins interacting via a nonlocal quartic interaction. The model has an O( N, ℤ), hyperoctahedral, symmetry. We show that the large N partition function admits a saddle point in which the symmetry is enhanced to O( N). We further demonstrate that this `matrix saddle' correctly computes large N observables at weak and strong coupling. The matrix saddle undergoes a continuous quantum phase transition at intermediate couplings. At the transition the matrix eigenvalue distribution becomes disconnected. The critical excitations are described by large N matrix quantum mechanics. At the critical point, the low energy excitations are waves propagating in an emergent 1 + 1 dimensional spacetime.

  6. Performance Appraisal for Matrix Management.

    ERIC Educational Resources Information Center

    Edwards, M. R.; Sproull, J. Ruth

    1985-01-01

    A matrix management system designed for use by a highly technical nuclear weapons research and development facility to improve productivity and flexibility by the use of multiple authority, responsibility, and accountability relationships is described. (MSE)

  7. Stochastic determination of matrix determinants.

    PubMed

    Dorn, Sebastian; Ensslin, Torsten A

    2015-07-01

    Matrix determinants play an important role in data analysis, in particular when Gaussian processes are involved. Due to currently exploding data volumes, linear operations-matrices-acting on the data are often not accessible directly but are only represented indirectly in form of a computer routine. Such a routine implements the transformation a data vector undergoes under matrix multiplication. While efficient probing routines to estimate a matrix's diagonal or trace, based solely on such computationally affordable matrix-vector multiplications, are well known and frequently used in signal inference, there is no stochastic estimate for its determinant. We introduce a probing method for the logarithm of a determinant of a linear operator. Our method rests upon a reformulation of the log-determinant by an integral representation and the transformation of the involved terms into stochastic expressions. This stochastic determinant determination enables large-size applications in Bayesian inference, in particular evidence calculations, model comparison, and posterior determination.

  8. Molybdenum disilicide alloy matrix composite

    DOEpatents

    Petrovic, John J.; Honnell, Richard E.; Gibbs, W. Scott

    1990-01-01

    Compositions of matter consisting of matrix matrials having silicon carbide dispersed throughout them and methods of making the compositions. A matrix material is an alloy of an intermetallic compound, molybdenum disilicide, and at least one secondary component which is a refractory silicide. The silicon carbide dispersant may be in the form of VLS whiskers, VS whiskers, or submicron powder or a mixture of these forms.

  9. Staggered chiral random matrix theory

    SciTech Connect

    Osborn, James C.

    2011-02-01

    We present a random matrix theory for the staggered lattice QCD Dirac operator. The staggered random matrix theory is equivalent to the zero-momentum limit of the staggered chiral Lagrangian and includes all taste breaking terms at their leading order. This is an extension of previous work which only included some of the taste breaking terms. We will also present some results for the taste breaking contributions to the partition function and the Dirac eigenvalues.

  10. Molybdenum disilicide alloy matrix composite

    DOEpatents

    Petrovic, John J.; Honnell, Richard E.; Gibbs, W. Scott

    1991-01-01

    Compositions of matter consisting of matrix materials having silicon carbide dispersed throughout them and methods of making the compositions. A matrix material is an alloy of an intermetallic compound, molybdenum disilicide, and at least one secondary component which is a refractory silicide. The silicon carbide dispersant may be in the form of VLS whiskers, VS whiskers, or submicron powder or a mixture of these forms.

  11. Molybdenum disilicide alloy matrix composite

    DOEpatents

    Petrovic, J.J.; Honnell, R.E.; Gibbs, W.S.

    1991-12-03

    Compositions of matter consisting of matrix materials having silicon carbide dispersed throughout them and methods of making the compositions are disclosed. A matrix material is an alloy of an intermetallic compound, molybdenum disilicide, and at least one secondary component which is a refractory silicide. The silicon carbide dispersant may be in the form of VLS whiskers, VS whiskers, or submicron powder or a mixture of these forms. 3 figures.

  12. Algorithmic deformation of matrix factorisations

    NASA Astrophysics Data System (ADS)

    Carqueville, Nils; Dowdy, Laura; Recknagel, Andreas

    2012-04-01

    Branes and defects in topological Landau-Ginzburg models are described by matrix factorisations. We revisit the problem of deforming them and discuss various deformation methods as well as their relations. We have implemented these algorithms and apply them to several examples. Apart from explicit results in concrete cases, this leads to a novel way to generate new matrix factorisations via nilpotent substitutions, and to criteria whether boundary obstructions can be lifted by bulk deformations.

  13. Universal Keplerian state transition matrix

    NASA Technical Reports Server (NTRS)

    Shepperd, S. W.

    1985-01-01

    A completely general method for computing the Keplerian state transition matrix in terms of Goodyear's universal variables is presented. This includes a new scheme for solving Kepler's problem which is a necessary first step to computing the transition matrix. The Kepler problem is solved in terms of a new independent variable requiring the evaluation of only one transcendental function. Furthermore, this transcendental function may be conveniently evaluated by means of a Gaussian continued fraction.

  14. The measurement of fracture energy at fiber-matrix interfaces

    SciTech Connect

    Pegoretti, A.; DiBenedetto, A.T.

    1996-12-31

    The primary function of the fiber-matrix interface in composite materials is to transmit stress from the polymer matrix to the high strength reinforcing fibers. When a fiber filament breaks, cracks will propagate from the broken fiber end either by interfacial debonding, transverse and conical matrix cracking or combinations of the three modes. The strength of the interface has been characterized using micromechanical tests, such as the single fiber fragmentation test and a variety of single fiber pull-out tests. Results are generally analyzed in terms of an {open_quotes}interfacial shear stress{close_quotes}, {tau}, or a critical energy release rate, G{sub c}. It is the objective of this study to measure directly the strain energy release rate, G{sub c} associated with each observable fracture mode and to determine the effect of constituent physical properties and interfacial adhesion on its magnitude.

  15. Research on Graphite Reinforced Glass Matrix Composites

    NASA Technical Reports Server (NTRS)

    Bacon, J. F.; Prewo, K. M.

    1977-01-01

    This report contains the results obtained in the first twelve months of research under NASA Langley Contract NAS1-14346 for the origination of graphite-fiber reinforced glass matrix composites. Included in the report is a summary of the research by other investigators in this area. The method selected to form the composites consisted of pulling the graphite fiber through a slurry containing powdered glass, winding up the graphite fiber and the glass it picks up on a drum, drying, cutting into segments, loading the tape segment into a graphite die, and hot pressing. During the course of the work, composites were made with a variety of graphite fibers in a C.G.W. 7740 (Pyrex) glass matrix. The graphite fibers used included Hercules HMS, Hercules HTS, Thornel 300S, and Celanese DG-102 and, of these, the Hercules HMS and Celanese DG-102 graphite fibers in C.G.W. 7740 gave the most interesting but widely different results. Hercules HMS fiber in C.G.W. 7740 glass (Pyrex) showed an average four-point flexural strength of 848 MPa or 127,300 psi. As the test temperature was raised from room temperature to 560 C in argon or vacuum, the strength was higher by 50 percent. However, in air, similar tests at 560 C gave a severe loss in strength. These composites also have good thermal cycle properties in argon or vacuum, greatly increased toughness compared to glass, and no loss in strength in a 100 cycle fatigue test. Celanese DG-102 fiber in C.G.W. 7740 glass (Pyrex) had a much lower flexural strength but did not suffer any loss in this strength when samples were heated to 560 C in air for 4 hrs.

  16. Purification of matrix metalloproteinases by column chromatography.

    PubMed

    Imai, Kazushi; Okada, Yasunori

    2008-01-01

    Matrix metalloproteinases (MMPs) are zinc endopeptidases composed of 23 members in humans, which belong to a subfamily of the metzincin superfamily. They play important roles in many pathophysiological events including development, organogenesis, angiogenesis, tissue remodeling and destruction, and cancer cell proliferation and progression by degradation of extracellular matrix (ECM) and non-ECM proteins and interaction with various molecules. Here, we present standard protocols for purification of native proMMPs (proMMP-1, -2, -3, -7, -9 and -10) and recombinant MT1-MMP (MMP-14) using conventional column chromatography. Purification steps comprise the initial common step [diethylaminoethyl (DEAE)-cellulose, Green A Dyematrex gel and gelatin-Sepharose columns], the second step for removal of nontarget proMMPs by immunoaffinity columns (anti-MMP-1 and/or anti-MMP-3 IgG-Sepharose columns) and the final step for further purification (IgG-Sepharose, DEAE-cellulose, Zn2+-chelate-Sepharose and/or gel filtration columns). Purified proMMPs and MMP are functionally active and suitable for biochemical analyses. The basic protocol for the purification from culture media takes approximately 7-10 d.

  17. Recycling of aluminum matrix composites

    SciTech Connect

    Nishida, Yoshinori; Izawa, Norihisa; Kuramasu, Yukio

    1999-03-01

    Separation of matrix metals in composites was tried on alumina short fiber-reinforced aluminum and 6061 alloy composites and SiC whisker-reinforced 6061 alloy composite for recycling. It is possible to separate molten matrix metals from fibers in the composites using fluxes that are used for melt treatment to remove inclusions. About 50 vol pct of the matrix metals was separated from the alumina short fiber-reinforced composites. The separation ratio of the matrix from the SiC whisker-reinforced 6061 alloy composite was low and about 20 vol pct. The separation mechanism was discussed thermodynamically using interface free energies. Since the flux/fiber interface energy is smaller than the aluminum/fiber interface energy, the replacement of aluminum with fluxes in composites takes place easily. Gases released by the decomposition of fluxes act an important role in pushing out the molten matrix metal from the composite. The role was confirmed by the great amount cavity formed in the composite after the matrix metal flowed out.

  18. Carbonate fuel cell matrix strengthening

    SciTech Connect

    Yuh, C.Y.; Haung, C.M.; Johnsen, R.

    1995-12-31

    The present baseline electrolyte matrix is a porous ceramic powder bed impregnated with alkali carbonate electrolyte. The matrix provides both ionic conduction and gas sealing. During fuel cell stack operation, the matrix experiences both mechanical and thermal stresses. Different mechanical characteristics of active and wet seal areas generate stress. Thermal stress is generated by nonuniform temperature distribution and thermal cycling. A carbonate fuel cell generally may experience planned and unplanned thermal cycles between 650 C and room temperature during its 40,000h life. During the cycling, the electrolyte matrix expands and contracts at a different rate from other cell components. Furthermore, the change in electrolyte volume associated with freezing/melting may generate additional thermal stress. Strengthening of the matrix may be beneficial for longer-term stability of the carbonate fuel cell with respect to repeated thermal cycling. Several promising strengtheners with improved chemical and mechanical stabilities were identified. Fibers provide the highest strengthening effect, followed by particulates. Matrix fabrication technique was successfully modified for uniformly incorporating the advanced strengtheners, maintaining the desired aspect ratio. Enhanced gas sealing demonstrated using the advanced matrices.

  19. Fiber/matrix adhesion in graphite/PEKK composites

    NASA Technical Reports Server (NTRS)

    Bucher, R. A.; Hinkley, J. A.

    1992-01-01

    Experiments with poly ether ketone ketone (PEKK) resin and AS-4, IM-7, and G30-500 fibers showed excellent correlation between resin/fiber contact angle and composite transverse flexural strength as measures of resin/fiber interfacial strength. Both tests indicate the strongest interface for G30-500/PEKK followed by IM-7/PEKK and AS-4/PEKK. Also discussed are fiber effects on interlaminar fracture and on the in situ crystallization of the matrix during composite fabrication.

  20. Glycosylation of Dentin Matrix Protein 1 is critical for osteogenesis.

    PubMed

    Sun, Yao; Weng, Yuteng; Zhang, Chenyang; Liu, Yi; Kang, Chen; Liu, Zhongshuang; Jing, Bo; Zhang, Qi; Wang, Zuolin

    2015-12-04

    Proteoglycans play important roles in regulating osteogenesis. Dentin matrix protein 1 (DMP1) is a highly expressed bone extracellular matrix protein that regulates both bone development and phosphate metabolism. After glycosylation, an N-terminal fragment of DMP1 protein was identified as a new proteoglycan (DMP1-PG) in bone matrix. In vitro investigations showed that Ser(89) is the key glycosylation site in mouse DMP1. However, the specific role of DMP1 glycosylation is still not understood. In this study, a mutant DMP1 mouse model was developed in which the glycosylation site S(89) was substituted with G(89) (S89G-DMP1). The glycosylation level of DMP1 was down-regulated in the bone matrix of S89G-DMP1 mice. Compared with wild type mice, the long bones of S89G-DMP1 mice showed developmental changes, including the speed of bone remodeling and mineralization, the morphology and activities of osteocytes, and activities of both osteoblasts and osteoclasts. These findings indicate that glycosylation of DMP1 is a key posttranslational modification process during development and that DMP1-PG functions as an indispensable proteoglycan in osteogenesis.

  1. Fracture criteria for discontinuously reinforced metal matrix composites

    NASA Technical Reports Server (NTRS)

    Rack, H. J.; Goree, J. G.; Albritton, J.; Ratnarparkhi, P.

    1988-01-01

    The effect of sample configuration on the details of initial crack propagation in discontinuously whisker reinforced aluminum metal matrix composites was investigated. Care was taken to allow direct comparison of fracture toughness values utilizing differing sample configurations and orientations, holding all materials variables constant, e.g., extrusion ration, heat treatment, and chemistry.

  2. Glycosylation of Dentin Matrix Protein 1 is critical for osteogenesis

    PubMed Central

    Sun, Yao; Weng, Yuteng; Zhang, Chenyang; Liu, Yi; Kang, Chen; Liu, Zhongshuang; Jing, Bo; Zhang, Qi; Wang, Zuolin

    2015-01-01

    Proteoglycans play important roles in regulating osteogenesis. Dentin matrix protein 1 (DMP1) is a highly expressed bone extracellular matrix protein that regulates both bone development and phosphate metabolism. After glycosylation, an N-terminal fragment of DMP1 protein was identified as a new proteoglycan (DMP1-PG) in bone matrix. In vitro investigations showed that Ser89 is the key glycosylation site in mouse DMP1. However, the specific role of DMP1 glycosylation is still not understood. In this study, a mutant DMP1 mouse model was developed in which the glycosylation site S89 was substituted with G89 (S89G-DMP1). The glycosylation level of DMP1 was down-regulated in the bone matrix of S89G-DMP1 mice. Compared with wild type mice, the long bones of S89G-DMP1 mice showed developmental changes, including the speed of bone remodeling and mineralization, the morphology and activities of osteocytes, and activities of both osteoblasts and osteoclasts. These findings indicate that glycosylation of DMP1 is a key posttranslational modification process during development and that DMP1-PG functions as an indispensable proteoglycan in osteogenesis. PMID:26634432

  3. Matrix Gla Protein polymorphisms are associated with coronary artery calcification

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Matrix Gla Protein (MGP) is a key regulator of vascular calcification. Genetic variation at the MGP locus could modulate the development of coronary artery calcification (CAC). We examined the cross-sectional association between MGP SNPs [rs1800802 (T-138C), rs1800801 (G-7A),and rs4236 (Ala102Thr)...

  4. Matrix-assisted diffusion-ordered spectroscopy: choosing a matrix.

    PubMed

    Gramosa, Nilce V; Ricardo, Nágila M S P; Adams, Ralph W; Morris, Gareth A; Nilsson, Mathias

    2016-06-07

    Diffusion-ordered spectroscopy (DOSY) is an important technique for separating the NMR signals of the components in a mixture, and relies on differences in diffusion coefficient. Standard DOSY experiments therefore struggle when the components of a mixture are of similar size, and hence diffuse at similar rates. Fortunately, the diffusion coefficients of solutes can be manipulated by changing the matrix in which they diffuse, using matrix components that interact differentially with them, a technique known as matrix-assisted DOSY. In the present investigation, we evaluate the performance of a number of new, previously used, and mixed matrices with an informative test mixture: the three positional isomers of dihydroxybenzene. The aim of this work is to present the matrix-assisted DOSY user with information about the potential utility of a set of matrices (and combinations of matrices), including ionic and non-ionic surfactants, complexing agents, polymers, and mixed solvents. A variety of matrices improved the diffusion resolution of the signals of the test system, with the best separation achieved by mixed micelles of sodium dodecyl sulfate and cetyl trimethylammonium bromide. The use of mixed matrices offers great potential for the analyst to tailor the matrix to a particular sample under study. © 2016 The Authors Magnetic Resonance in Chemistry Published by John Wiley & Sons, Ltd.

  5. On the Differentiation Matrix for Daubechies-Based Wavelets on an Interval

    DTIC Science & Technology

    1993-12-01

    wavelet systems defined on an interval. In particular, the differentiation accuracy of the dif- ferentiation matrices constructed from the currently...the product of three ma- trices: E) = CDC. The three matrices are defined as follows: "* The first matrix C is a quadrature matrix mapping from...quadrature matrices and ill- conditioned 3-point quadrature matrices . 6. Quadrature Matrix C Using Samples: C performs the mapping, C : g --+ f. For the D4

  6. The Astrobiology Matrix and the "Drake Matrix" in Education

    NASA Technical Reports Server (NTRS)

    Mizser, A.; Kereszturi, A.

    2003-01-01

    We organized astrobiology lectures in the Eotvos Lorand University of Sciences and the Polaris Observatory in 2002. We present here the "Drake matrix" for the comparison of the astrobiological potential of different bodies [1], and astrobiology matrix for the visualization of the interdisciplinary connections between different fields of astrobiology. Conclusion: In Hungary it is difficult to integrate astrobiology in the education system but the great advantage is that it can connect different scientific fields and improve the view of students. We would like to get in contact with persons and organizations who already have experience in the education of astrobiology.

  7. Relativistic Dipole Matrix Element Zeros

    NASA Astrophysics Data System (ADS)

    Lajohn, L. A.; Pratt, R. H.

    2002-05-01

    There is a special class of relativistic high energy dipole matrix element zeros (RZ), whose positions with respect to photon energy ω , only depend on the bound state l quantum number according to ω^0=mc^2/(l_b+1) (independent of primary quantum number n, nuclear charge Z, central potential V and dipole retardation). These RZ only occur in (n,l_b,j_b)arrow (ɛ , l_b+1,j_b) transitions such as ns_1/2arrow ɛ p_1/2; np_3/2arrow ɛ d_3/2: nd_5/2arrow ɛ f_5/2 etc. The nonrelativistic limit of these matrix elements can be established explicitly in the Coulomb case. Within the general matrix element formalism (such as that in [1]); when |κ | is substituted for γ in analytic expressions for matrix elements, the zeros remain, but ω^0 now becomes dependent on n and Z. When the reduction to nonrelativistic form is completed by application of the low energy approximation ω mc^2 mc^2, the zeros disappear. This nonzero behavior was noted in nonrelativistic dipole Coulomb matrix elements by Fano and Cooper [2] and later proven by Oh and Pratt[3]. (J. H. Scofield, Phys. Rev. A 40), 3054 (1989 (U. Fano and J. W. Cooper, Rev. Mod. Phys. 40), 441 (1968). (D. Oh and R. H. Pratt, Phys. Rev. A 34), 2486 (1986); 37, 1524 (1988); 45, 1583 (1992).

  8. Matrix factorizations and elliptic fibrations

    NASA Astrophysics Data System (ADS)

    Omer, Harun

    2016-09-01

    I use matrix factorizations to describe branes at simple singularities of elliptic fibrations. Each node of the corresponding Dynkin diagrams of the ADE-type singularities is associated with one indecomposable matrix factorization which can be deformed into one or more factorizations of lower rank. Branes with internal fluxes arise naturally as bound states of the indecomposable factorizations. Describing branes in such a way avoids the need to resolve singularities. This paper looks at gauge group breaking from E8 fibers down to SU (5) fibers due to the relevance of such fibrations for local F-theory GUT models. A purpose of this paper is to understand how the deformations of the singularity are understood in terms of its matrix factorizations. By systematically factorizing the elliptic fiber equation, this paper discusses geometries which are relevant for building semi-realistic local models. In the process it becomes evident that breaking patterns which are identical at the level of the Kodaira type of the fibers can be inequivalent at the level of matrix factorizations. Therefore the matrix factorization picture supplements information which the conventional less detailed descriptions lack.

  9. Association of Chromosome Territories with the Nuclear Matrix

    PubMed Central

    Ma, Hong; Siegel, Alan J.; Berezney, Ronald

    1999-01-01

    To study the possible role of the nuclear matrix in chromosome territory organization, normal human fibroblast cells are treated in situ via classic isolation procedures for nuclear matrix in the absence of nuclease (e.g., DNase I) digestion, followed by chromosome painting. We report for the first time that chromosome territories are maintained intact on the nuclear matrix. In contrast, complete extraction of the internal nuclear matrix components with RNase treatment followed by 2 M NaCl results in the disruption of higher order chromosome territory architecture. Correlative with territorial disruption is the formation of a faint DNA halo surrounding the nuclear lamina and a dispersive effect on the characteristically discrete DNA replication sites in the nuclear interior. Identical results were obtained using eight different human chromosome paints. Based on these findings, we developed a fractionation strategy to release the bulk of nuclear matrix proteins under conditions where the chromosome territories are maintained intact. A second treatment results in disruption of the chromosome territories in conjunction with the release of a small subset of acidic proteins. These proteins are distinct from the major nuclear matrix proteins and may be involved in mediating chromosome territory organization. PMID:10444063

  10. Methodology and utility of a job-exposure matrix

    SciTech Connect

    Plato, N.; Steineck, G. )

    1993-01-01

    We have previously reported a study in which a job-exposure matrix was applied to census data, identifying, e.g., polychlorinated biphenyls (PCBs) and creosote as increasing the risk of urothelial cancer. In this article, we expand on some theoretical issues, and present detailed accounts of constructed linkages for PCBs, creosote, and phenols. For agents of interest, one should emphasize the positive predictive value rather than the sensitivity in the construction of the matrix. The reverse is true for confounding factors; to avoid residual confounding after restriction to subjects unexposed for the confounding factors, one should emphasize sensitivity, possibly compromising the positive predictive value. This discrepancy between agents of interest and confounding factors may limit the application of a general matrix for studying several different diseases. The construction of the matrix is much harder, if sensitivity rather than positive predictive value is emphasized for an agent. Confounding from industry-related agents arises due to a true mixed exposure in certain work tasks, but also due to a gross classification of occupations in the census. One should not confuse different levels of the positive predictive value with exposure dose. A dose-response with different levels of positive predictive value reflects an accuracy of the matrix, not a biological phenomenon. Studies with exposure information from a job-exposure matrix applied to registers with scant information on occupation and industry may be warranted for exposures and diseases for which previous studies with a detailed documentation of exposure have low precision. 31 refs.

  11. Triangular G2-Splines

    DTIC Science & Technology

    2000-01-01

    energy [1]. Judging the visual ap- pearance of the surfaces by their isophotes we got the best results with the 340 H. Prautzsch and G. Umlauf Fig. 7...An initial control net (left), parameter lines of the resulting G2-surface (middle), top-view of the surface showing isophotes (right). functional F...construction. The initial triangular control net has an irregular vertex of valence 5. The isophotes confirm that the resulting surface is G 2. Fig. 8

  12. Noncommutative spaces from matrix models

    NASA Astrophysics Data System (ADS)

    Lu, Lei

    Noncommutative (NC) spaces commonly arise as solutions to matrix model equations of motion. They are natural generalizations of the ordinary commutative spacetime. Such spaces may provide insights into physics close to the Planck scale, where quantum gravity becomes relevant. Although there has been much research in the literature, aspects of these NC spaces need further investigation. In this dissertation, we focus on properties of NC spaces in several different contexts. In particular, we study exact NC spaces which result from solutions to matrix model equations of motion. These spaces are associated with finite-dimensional Lie-algebras. More specifically, they are two-dimensional fuzzy spaces that arise from a three-dimensional Yang-Mills type matrix model, four-dimensional tensor-product fuzzy spaces from a tensorial matrix model, and Snyder algebra from a five-dimensional tensorial matrix model. In the first part of this dissertation, we study two-dimensional NC solutions to matrix equations of motion of extended IKKT-type matrix models in three-space-time dimensions. Perturbations around the NC solutions lead to NC field theories living on a two-dimensional space-time. The commutative limit of the solutions are smooth manifolds which can be associated with closed, open and static two-dimensional cosmologies. One particular solution is a Lorentzian fuzzy sphere, which leads to essentially a fuzzy sphere in the Minkowski space-time. In the commutative limit, this solution leads to an induced metric that does not have a fixed signature, and have a non-constant negative scalar curvature, along with singularities at two fixed latitudes. The singularities are absent in the matrix solution which provides a toy model for resolving the singularities of General relativity. We also discussed the two-dimensional fuzzy de Sitter space-time, which has irreducible representations of su(1,1) Lie-algebra in terms of principal, complementary and discrete series. Field

  13. Tests for Linear Trend in the Smallest Eigenvalues of the Correlation Matrix.

    ERIC Educational Resources Information Center

    Bentler, Peter M.; Yuan, Ke-Hai

    1998-01-01

    A test for linear trend among a set of eigenvalues of a correlation matrix is described. It is a generalization of G. Anderson's (1965) test for the equality of eigenvalues and extends the present authors' previous work on linear trends in eigenvalues of a covariance matrix. The linear trend hypothesis is discussed. (SLD)

  14. Soil matrix and macropore biodegradation of 2,4-D

    SciTech Connect

    Pivetz, B.E.; Steenhuis, T.S.

    1995-07-01

    Preferential flow of pesticides in macropores can lead to decreased travel times through the vadose zone and increased groundwater contamination. Macropores, however, may present a favorable environment for biodegradation because of greater oxygen, nutrient, and substrate supply, and higher microbial populations in earthworm burrows, compared to the soil matrix. The biodegradation of 2,4-dichlorophenoxyacetic acid (2,4-D) was measured in macropores and soil matrix of packed soil columns (7.0-cm diam., 10-cm length) and undisturbed cores contained as well-defined artificial macropore and the undisturbed cores contained earthworm-burrow macropores. A 50 {mu}g/L 2,4-D solution was continuously applied to the unsaturated soil surface and breakthrough curves (BTCs) indicating pesticide loss in the effluent were obtained from the soil matrix and macropore flow paths. Biodegradation rates were calculated separately for each flow path by comparing the BTCs to BTCs representing abiotic conditions, and dividing the 2,4-D loss by the travel time through each flow path. The biodegradation rates increased with time in both flow paths, and the final biodegradation rate in the macropore region surpassed that of the matrix, presumably because of increased microbial populations in the macropore. Complete loss of the 2,4-D in both flow paths was observed after continuous application of 2,4-D for 400 h, with maximum column-averaged 2,4-D loss rates of 0.879 {mu}g/(L h) in the matrix and 1.073 {mu}g/(L h) in the macropore. Biodegradation of 2,4-D was also observed in the macropore and matrix regions of the undisturbed soil cores. 19 refs., 7 figs., 2 tabs.

  15. Matrix model approach to cosmology

    NASA Astrophysics Data System (ADS)

    Chaney, A.; Lu, Lei; Stern, A.

    2016-03-01

    We perform a systematic search for rotationally invariant cosmological solutions to toy matrix models. These models correspond to the bosonic sector of Lorentzian Ishibashi, Kawai, Kitazawa and Tsuchiya (IKKT)-type matrix models in dimensions d less than ten, specifically d =3 and d =5 . After taking a continuum (or commutative) limit they yield d -1 dimensional Poisson manifolds. The manifolds have a Lorentzian induced metric which can be associated with closed, open, or static space-times. For d =3 , we obtain recursion relations from which it is possible to generate rotationally invariant matrix solutions which yield open universes in the continuum limit. Specific examples of matrix solutions have also been found which are associated with closed and static two-dimensional space-times in the continuum limit. The solutions provide for a resolution of cosmological singularities, at least within the context of the toy matrix models. The commutative limit reveals other desirable features, such as a solution describing a smooth transition from an initial inflation to a noninflationary era. Many of the d =3 solutions have analogues in higher dimensions. The case of d =5 , in particular, has the potential for yielding realistic four-dimensional cosmologies in the continuum limit. We find four-dimensional de Sitter d S4 or anti-de Sitter AdS4 solutions when a totally antisymmetric term is included in the matrix action. A nontrivial Poisson structure is attached to these manifolds which represents the lowest order effect of noncommutativity. For the case of AdS4 , we find one particular limit where the lowest order noncommutativity vanishes at the boundary, but not in the interior.

  16. Shrinkage estimation of the realized relationship matrix

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The additive relationship matrix plays an important role in mixed model prediction of breeding values. For genotype matrix X (loci in columns), the product XX' is widely used as a realized relationship matrix, but the scaling of this matrix is ambiguous. Our first objective was to derive a proper ...

  17. Google matrix of the world network of economic activities

    NASA Astrophysics Data System (ADS)

    Kandiah, Vivek; Escaith, Hubert; Shepelyansky, Dima L.

    2015-07-01

    Using the new data from the OECD-WTO world network of economic activities we construct the Google matrix G of this directed network and perform its detailed analysis. The network contains 58 countries and 37 activity sectors for years 1995 and 2008. The construction of G, based on Markov chain transitions, treats all countries on equal democratic grounds while the contribution of activity sectors is proportional to their exchange monetary volume. The Google matrix analysis allows to obtain reliable ranking of countries and activity sectors and to determine the sensitivity of CheiRank-PageRank commercial balance of countries in respect to price variations and labor cost in various countries. We demonstrate that the developed approach takes into account multiplicity of network links with economy interactions between countries and activity sectors thus being more efficient compared to the usual export-import analysis. The spectrum and eigenstates of G are also analyzed being related to specific activity communities of countries.

  18. Measuring Sparticles with the Matrix Element

    SciTech Connect

    Alwall, Johan; Freitas, Ayres; Mattelaer, Olivier; /INFN, Rome3 /Rome III U. /Louvain U.

    2012-04-10

    We apply the Matrix Element Method (MEM) to mass determination of squark pair production with direct decay to quarks and LSP at the LHC, showing that simultaneous mass determination of squarks and LSP is possible. We furthermore propose methods for inclusion of QCD radiation effects in the MEM. The goal of the LHC at CERN, scheduled to start this year, is to discover new physics through deviations from the Standard Model (SM) predictions. After discovery of deviations from the SM, the next step will be classification of the new physics. An important first goal in this process will be establishing a mass spectrum of the new particles. One of the most challenging scenarios is pair-production of new particles which decay to invisible massive particles, giving missing energy signals. Many methods have been proposed for mass determination in such scenarios (for a recent list of references, see e.g. [1]). In this proceeding, we report the first steps in applying the Matrix Element Method (MEM) in the context of supersymmetric scenarios giving missing energy signals. After a quick review of the MEM, we will focus on squark pair production, a process where other mass determination techniques have difficulties to simultaneously determine the LSP and squark masses. Finally, we will introduce methods to extend the range of validity of the MEM, by taking into account initial state radiation (ISR) in the method.

  19. The G4 Genome

    PubMed Central

    Maizels, Nancy; Gray, Lucas T.

    2013-01-01

    Recent experiments provide fascinating examples of how G4 DNA and G4 RNA structures—aka quadruplexes—may contribute to normal biology and to genomic pathologies. Quadruplexes are transient and therefore difficult to identify directly in living cells, which initially caused skepticism regarding not only their biological relevance but even their existence. There is now compelling evidence for functions of some G4 motifs and the corresponding quadruplexes in essential processes, including initiation of DNA replication, telomere maintenance, regulated recombination in immune evasion and the immune response, control of gene expression, and genetic and epigenetic instability. Recognition and resolution of quadruplex structures is therefore an essential component of genome biology. We propose that G4 motifs and structures that participate in key processes compose the G4 genome, analogous to the transcriptome, proteome, or metabolome. This is a new view of the genome, which sees DNA as not only a simple alphabet but also a more complex geography. The challenge for the future is to systematically identify the G4 motifs that form quadruplexes in living cells and the features that confer on specific G4 motifs the ability to function as structural elements. PMID:23637633

  20. [Matrix Support: a bibliographical study].

    PubMed

    Iglesias, Alexandra; Avellar, Luziane Zacché

    2014-09-01

    This article presents a bibliographical review of matrix support in mental health. A search was conducted in the Virtual Health Library and the LILACS, SciELO and Google Scholar databases using the key words: "matrix support in mental health." Fourteen articles were located with the desired characteristics, which indicates that only a restricted number of publications are in circulation. The articles were analyzed with respect to their structural and methodological aspects, which revealed the absolute predominance of the use of qualitative methods and health professionals as the target research population. The same articles were then analyzed for their theoretical discussions. Among other issues, the importance of matrix support to enhance the primary health care teams provided to people suffering from psychic distress is highlighted. However, there is still considerable confusion regarding the proposal of the matrix support and shared responsibilities between teams of reference and mental health professionals, which emphasizes the need for training of these professionals, as well as better coordination and organization of the mental health care network.

  1. Integrability and generalized monodromy matrix

    SciTech Connect

    Lhallabi, T.; Moujib, A.

    2007-09-15

    We construct the generalized monodromy matrix M-circumflex({omega}) of two-dimensional string effective action by introducing the T-duality group properties. The integrability conditions with general solutions depending on spectral parameter are given. This construction is investigated for the exactly solvable Wess, Zumino, Novikov, and Witten model in pp-wave limit when B=0.

  2. The Enrollment Analysis Matrix Concept.

    ERIC Educational Resources Information Center

    Chisholm, Mark

    The underlying assumptions and the structure of the enrollment analysis matrix (EAM) concept are discussed. EAM is a component of the Strategic Planning Project of the National Center for Higher Education Management Systems. EAM relates changes in the population of potential students external to the institution to the impacts that might result…

  3. The Lucas p-matrix

    NASA Astrophysics Data System (ADS)

    Kuhapatanakul, Kantaphon

    2015-11-01

    In this note, we study the Fibonacci and Lucas p-numbers. We introduce the Lucas p-matrix and companion matrices for the sums of the Fibonacci and Lucas p-numbers to derive some interesting identities of the Fibonacci and Lucas p-numbers.

  4. Matrix Algorithms in Signal Processing

    DTIC Science & Technology

    1990-08-01

    low rank perturbations with applications, SIAM J. MATRIX ANAL. APPL. 9, 40-58 (1988). [2] (with P . Arbenz and W. Gander), Restricted rank...key idea is to approximate the secular equation by an integral and then bound the integral using the ideas of Gauss- Radau integration. The Lanczos

  5. The Spin Structure Function g2

    SciTech Connect

    Rock, Stephen E.

    2003-02-27

    We have measured the spin structure functions g{sub 2}{sup p} and g{sub 2}{sup d} over the kinematic range 0.02 {le} x {le} 0.8 and 0.7 {le} Q{sup 2} {le} 20 GeV{sup 2} by scattering 29.1 and 32.3 GeV longitudinally polarized electrons from transversely polarized NH{sub 3} and {sup 6}LiD targets. Our measured g{sub 2} approximately follows the twist-2 Wandzura-Wilczek calculation. The twist-3 reduced matrix elements d{sub 2}{sup p} and d{sub 2}{sup n} are less than two standard deviations from zero. The data are inconsistent with the Burkhardt-Cottingham sum rule. The Efremov-Leader-Teryaev integral is consistent with zero within our measured kinematic range.

  6. Electrocomposite of Alumina in Nickel Matrix

    NASA Technical Reports Server (NTRS)

    Xiong-Skiba, Pei; Hulguin, Ryan; Engelhaupt, Darell; Ramsey, Brian

    2004-01-01

    Nickel/aluminum oxide composite was electroformed in a sulfamate bath with 50 g/L of 0.05-micron aluminum oxide powder. Different plating methods including direct current plating, periodic pulse plating, and periodic reverse pulse plating were used. With conventional direct current plating, the maximum particle inclusion in the nickel matrix remains about 2% (wt). However, much higher percentile particle inclusions were achieved when a specific pulse reversal plating technique was applied. The particle incorporation approaches theoretical maximum when the deposit thickness per cycle approaches the particle diameter size at lower duty cycle. The highest particle incorporation achieved is 23% (by weight). Conceptual models interpreting the dramatic differences in the results of these plating methods were also proposed.

  7. G3 Program

    EPA Pesticide Factsheets

    The G3 initiative was designed to build a collaborative network for small to mid-sized towns and communities that are interested in adopting Green Streets to address urban stormwater, improve community health and livability, and encourage economic growth.

  8. G4beamline

    SciTech Connect

    2011-05-24

    G4beamline is a single-particle-tracking simulation code based on the Geant4 toolkit. It is specifically optimized for the realistic evaluation of beam lines. It is especially useful for evaluating future muon facilities.

  9. Origin of Chondrules and Matrix in Carbonaceous Chondrites

    NASA Astrophysics Data System (ADS)

    Palme, H.; Spettel, B.; Ikeda, Y.

    1993-07-01

    We have recently shown that in Allende, chondrules and matrix are complementary in composition. Chondrules have low Fe/Cr ratios and matrix has high Fe/Cr ratios; the bulk meteorite has the CI ratio. Chondrules on the average have Ca/Al ratios below the solar system ratio of 1.10, which is also the bulk Allende ratio; matrix and related dark inclusions have ratios above 1.10. It was therefore concluded that chondrules and matrix formed from a single reservoir characteristic of the bulk Allende composition [1,2]. Recent reports on the CV meteorite Y-86751 [3,4] indicated the opposite relationship, with high Ca/Al ratios in chondrules and low ratios in matrix. Different compositions of individual components of Y-86751 and of Allende but similar bulk compositions of both meteorites may reveal important details on the preaccretionary evolution of the carbonaceous chondrites. We have therefore begun chemical analyses of the bulk of Y-86751 and its individual lithic components, chondrules, matrix, amoeboid olivine inclusions, Ca,Al-rich inclusions, etc. Results of the bulk analysis of Y-86751 show that this meteorite has (within the accuracy of the analysis) the same bulk composition as Allende. In particular, the Ca/Al ratio is within 3% of the average solar system ratio of 1.1 (by weight). The only statistically resolvable difference is the 50% higher content of Zn in Y-86751. Major-element INA analyses indicate a Ca/Al ratio above the chondritic ratio for several chondrules and opposite to that of average Allende chondrules [1]. Matrix samples have a tendency for low Ca/Al ratios, confirming EMP-matrix analyses [4]. The separates are presently analyzed for a large number of trace elements. After the analyses, separates will be investigated petrographically. The apparent disequilibrium among Allende components and the strong compositional zoning of olivine grains constrain the thermal history of the Allende parent body [e.g., 5]. Any metamorphic redistribution of Ca or

  10. Mitochondrial matrix P53 sensitizes cells to oxidative stress☆

    PubMed Central

    Koczor, Christopher A.; Torres, Rebecca A.; Fields, Earl J.; Boyd, Amy; Lewis, William

    2013-01-01

    A mitochondrial matrix-specific p53 construct (termed p53–290) in HepG2 cells was utilized to determine the impact of p53 in the mitochondrial matrix following oxidative stress. H2O2 exposure reduced cellular proliferation similarly in both p53–290 and vector cells, and p53–290 cells demonstrating decreased cell viability at 1 mM H2O2 (~85% viable). Mitochondrial DNA (mtDNA) abundance was decreased in a dose-dependent manner in p53–290 cells while no change was observed in vector cells. Oximetric analysis revealed reduced maximal respiration and reserve capacity in p53–290 cells. Our results demonstrate that mitochondrial matrix p53 sensitizes cells to oxidative stress by reducing mtDNA abundance and mitochondrial function. PMID:23499753

  11. Hypergravity Stimulates Osteoblast Proliferation Via Matrix-Integrin-Signaling Pathways

    NASA Technical Reports Server (NTRS)

    Vercoutere, W.; Parra, M.; Roden, C.; DaCosta, M.; Wing, A.; Damsky, C.; Holton, E.; Searby, N.; Globus, R.; Almeida, E.

    2003-01-01

    Extensive characterizations of the physiologic consequences of microgravity and gravity indicate that lack of weight-bearing may cause tissue atrophy through cellular and subcellular level mechanisms. We hypothesize that gravity is needed for the efficient transduction of cell growth and survival signals from the extra-cellular matrix (ECM) in mechanosensitive tissues. Recent work from our laboratory and from others shows that an increase of gravity increases bone cell growth and survival. We found that 50-g hypergravity stimulation increased osteoblast proliferation for cells grown on Collagen Type I and Fibronectin, but not on Laminin or uncoated plastic. This may be a tissue-specific response, because 50-g hypergravity stimulation caused no increase in proliferation for primary rat fibroblasts. These results combined with RT-PCR for all possible integrins indicate that beta1 integrin subunit may be involved. The osteoblast proliferation response on Collagen Type I was greater at 25-g than at 10-g or 50-g; 24-h duration of hypergravity was necessary to see an increase in proliferation. Survival was enhanced during hypergravity stimulation by the presence of matrix. Flow cytometry analysis indicated that cell cycle may be altered; BrdU incorporation in proliferating cells showed an increase in the number of actively dividing cells from about 60% at 1-g to over 90% at 25-g. To further investigate the molecular components involved, we applied fluorescence labeling of cytoskeletal and signaling molecules to cells after 2 to 30 minutes of hypergravity stimulation. While structural components did not appear to be altered, phosphorylation increased, indicating that signaling pathways may be activated. These data indicate that gravity mechanostimulation of osteoblast proliferation involves specific matrix-integrin signaling pathways which are sensitive to duration and g-level.

  12. M* G€* GÈ****/ .25 ýÿg*ûÿg»ûÿg¹÷ÿg-ûÿg8*fh f* f»

    EPA Pesticide Factsheets

    2015-09-01

    ... f$*fb*fÃ*fûýÿgÞóÿg$íÿg)ìÿgNïÿg)õÿg†øÿg*öÿg¬õÿg,óÿg*óÿg›öÿgúóÿg: æÿgpÛÿgjÒÿgzÈÿg*ÅÿgFÎÿg˜âÿgîýÿgÕ*f#'f 2f–3f**fc*f*ìÿgìÖÿg¯Âÿg ... f#. ...

  13. q-Virasoro constraints in matrix models

    NASA Astrophysics Data System (ADS)

    Nedelin, Anton; Zabzine, Maxim

    2017-03-01

    The Virasoro constraints play the important role in the study of matrix models and in understanding of the relation between matrix models and CFTs. Recently the localization calculations in supersymmetric gauge theories produced new families of matrix models and we have very limited knowledge about these matrix models. We concentrate on elliptic generalization of hermitian matrix model which corresponds to calculation of partition function on S 3 × S 1 for vector multiplet. We derive the q-Virasoro constraints for this matrix model. We also observe some interesting algebraic properties of the q-Virasoro algebra.

  14. Structure of collagen-glycosaminoglycan matrix and the influence to its integrity and stability.

    PubMed

    Bi, Yuying; Patra, Prabir; Faezipour, Miad

    2014-01-01

    Glycosaminoglycan (GAG) is a chain-like disaccharide that is linked to polypeptide core to connect two collagen fibrils/fibers and provide the intermolecular force in Collagen-GAG matrix (C-G matrix). Thus, the distribution of GAG in C-G matrix contributes to the integrity and mechanical properties of the matrix and related tissue. This paper analyzes the transverse isotropic distribution of GAG in C-G matrix. The angle of GAGs related to collagen fibrils is used as parameters to qualify the GAGs isotropic characteristic in both 3D and 2D rendering. Statistical results included that over one third of GAGs were perpendicular directed to collagen fibril with symmetrical distribution for both 3D matrix and 2D plane cross through collagen fibrils. The three factors tested in this paper: collagen radius, collagen distribution, and GAGs density, were not statistically significant for the strength of Collagen-GAG matrix in 3D rendering. However in 2D rendering, a significant factor found was the radius of collagen in matrix for the GAGs directed to orthogonal plane of Collagen-GAG matrix. Between two cross-section selected from Collagen-GAG matrix model, the plane cross through collagen fibrils was symmetrically distributed but the total percentage of perpendicular directed GAG was deducted by decreasing collagen radius. There were some symmetry features of GAGs angle distribution in selected 2D plane that passed through space between collagen fibrils, but most models showed multiple peaks in GAGs angle distribution. With less GAGs directed to perpendicular of collagen fibril, strength in collagen cross-section weakened. Collagen distribution was also a factor that influences GAGs angle distribution in 2D rendering. True hexagonal collagen packaging is reported in this paper to have less strength at collagen cross-section compared to quasi-hexagonal collagen arrangement. In this work focus is on GAGs matrix within the collagen and its relevance to anisotropy.

  15. Scrambling with matrix black holes

    NASA Astrophysics Data System (ADS)

    Brady, Lucas; Sahakian, Vatche

    2013-08-01

    If black holes are not to be dreaded sinks of information but rather fully described by unitary evolution, they must scramble in-falling data and eventually leak it through Hawking radiation. Sekino and Susskind have conjectured that black holes are fast scramblers; they generate entanglement at a remarkably efficient rate, with the characteristic time scaling logarithmically with the entropy. In this work, we focus on Matrix theory—M-theory in the light-cone frame—and directly probe the conjecture. We develop a concrete test bed for quantum gravity using the fermionic variables of Matrix theory and show that the problem becomes that of chains of qubits with an intricate network of interactions. We demonstrate that the black hole system evolves much like a Brownian quantum circuit, with strong indications that it is indeed a fast scrambler. We also analyze the Berenstein-Maldacena-Nastase model and reach the same tentative conclusion.

  16. Sapphire reinforced alumina matrix composites

    NASA Technical Reports Server (NTRS)

    Jaskowiak, Martha H.; Setlock, John A.

    1994-01-01

    Unidirectionally reinforced A1203 matrix composites have been fabricated by hot pressing. Approximately 30 volume % of either coated or uncoated sapphire fiber was used as reinforcement. Unstabilized ZrO2 was applied as the fiber coating. Composite mechanical behavior was analyzed both after fabrication and after additional heat treatment. The results of composite tensile tests were correlated with fiber-matrix interfacial shear strengths determined from fiber push-out tests. Substantially higher strength and greater fiber pull-out were observed for the coated fiber composites for all processing conditions studied. The coated fiber composites retained up to 95% and 87% of their as-fabricated strength when heat treated at 14000C for 8 or 24 hours, respectively. Electron microscopy analysis of the fracture surfaces revealed extensive fiber pull-out both before and after heat treatment.

  17. Corrosion of Titanium Matrix Composites

    SciTech Connect

    Covino, B.S., Jr.; Alman, D.E.

    2002-09-22

    The corrosion behavior of unalloyed Ti and titanium matrix composites containing up to 20 vol% of TiC or TiB{sub 2} was determined in deaerated 2 wt% HCl at 50, 70, and 90 degrees C. Corrosion rates were calculated from corrosion currents determined by extrapolation of the tafel slopes. All curves exhibited active-passive behavior but no transpassive region. Corrosion rates for Ti + TiC composites were similar to those for unalloyed Ti except at 90 degrees C where the composites were slightly higher. Corrosion rates for Ti + TiB{sub 2} composites were generally higher than those for unalloyed Ti and increased with higher concentrations of TiB{sub 2}. XRD and SEM-EDS analyses showed that the TiC reinforcement did not react with the Ti matrix during fabrication while the TiB{sub 2} reacted to form a TiB phase.

  18. High temperature polymer matrix composites

    NASA Technical Reports Server (NTRS)

    Meador, Michael A.

    1987-01-01

    With the increased emphasis on high performance aircraft the need for lightweight, thermal/oxidatively stable materials is growing. Because of their ease of fabrication, high specific strength, and ability to be tailored chemically to produce a variety of mechanical and physical properties, polymers and polymer matrix composites present themselves as attractive materials for a number of aeropropulsion applications. In the early 1970s researchers at the NASA Lewis Research Center developed a highly processable, thermally stable (600 F) polyimide, PMR-15. Since that time, PMR-15 has become commercially available and has found use in military aircraft, in particular, the F-404 engine for the Navy's F/A-18 strike fighter. The NASA Lewis'contributions to high temperature polymer matrix composite research will be discussed as well as current and future directions.

  19. Myocardial structure and matrix metalloproteinases.

    PubMed

    Aggeli, C; Pietri, P; Felekos, I; Rautopoulos, L; Toutouzas, K; Tsiamis, E; Stefanadis, C

    2012-01-01

    Metalloproteinases (MMPs) are enzymes which enhance proteolysis of extracellular matrix proteins. The pathophysiologic and prognostic role of MMPs has been demonstrated in numerous studies. The present review covers a wide a range of topics with regards to MMPs structural and functional properties, as well as their role in myocardial remodeling in several cardiovascular diseases. Moreover, the clinical and therapeutic implications from their assessment are highlighted.

  20. Tough high performance composite matrix

    NASA Technical Reports Server (NTRS)

    Pater, Ruth H. (Inventor); Johnston, Norman J. (Inventor)

    1994-01-01

    This invention is a semi-interpentrating polymer network which includes a high performance thermosetting polyimide having a nadic end group acting as a crosslinking site and a high performance linear thermoplastic polyimide. Provided is an improved high temperature matrix resin which is capable of performing in the 200 to 300 C range. This resin has significantly improved toughness and microcracking resistance, excellent processability, mechanical performance, and moisture and solvent resistances.

  1. Integrable matrix theory: Level statistics.

    PubMed

    Scaramazza, Jasen A; Shastry, B Sriram; Yuzbashyan, Emil A

    2016-09-01

    We study level statistics in ensembles of integrable N×N matrices linear in a real parameter x. The matrix H(x) is considered integrable if it has a prescribed number n>1 of linearly independent commuting partners H^{i}(x) (integrals of motion) [H(x),H^{i}(x)]=0, [H^{i}(x),H^{j}(x)]=0, for all x. In a recent work [Phys. Rev. E 93, 052114 (2016)2470-004510.1103/PhysRevE.93.052114], we developed a basis-independent construction of H(x) for any n from which we derived the probability density function, thereby determining how to choose a typical integrable matrix from the ensemble. Here, we find that typical integrable matrices have Poisson statistics in the N→∞ limit provided n scales at least as logN; otherwise, they exhibit level repulsion. Exceptions to the Poisson case occur at isolated coupling values x=x_{0} or when correlations are introduced between typically independent matrix parameters. However, level statistics cross over to Poisson at O(N^{-0.5}) deviations from these exceptions, indicating that non-Poissonian statistics characterize only subsets of measure zero in the parameter space. Furthermore, we present strong numerical evidence that ensembles of integrable matrices are stationary and ergodic with respect to nearest-neighbor level statistics.

  2. Using singular value decomposition to compute the conditioned cross-spectral density matrix and coherence functions

    SciTech Connect

    Smallwood, D.O.

    1995-08-07

    It is shown that the usual method for computing the coherence functions (ordinary, partial, and multiple) for a general multiple-input/multiple-output problem can be expressed as a modified form of Cholesky decomposition of the cross spectral density matrix of the inputs and outputs. The modified form of Cholesky decomposition used is G{sub zz} = LCL{prime}, where G is the cross spectral density matrix of inputs and outputs, L is a lower; triangular matrix with ones on the diagonal, and C is a diagonal matrix, and the symbol {prime} denotes the conjugate transpose. If a diagonal element of C is zero, the off diagonal elements in the corresponding column of L are set to zero. It is shown that the results can be equivalently obtained using singular value decomposition (SVD) of G{sub zz}. The formulation as a SVD problem suggests a way to order the inputs when a natural physical order of the inputs is absent.

  3. Penicillin G Procaine Injection

    MedlinePlus

    ... if you have or have ever had asthma, allergies, hay fever, hives, or kidney disease.tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while receiving penicillin G procaine injection, call your doctor.

  4. Penicillin G Benzathine Injection

    MedlinePlus

    ... if you have or have ever had asthma, allergies, hay fever, hives, or kidney disease.tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while receiving penicillin G benzathine injection, call your doctor.

  5. Fast polar decomposition of an arbitrary matrix

    NASA Technical Reports Server (NTRS)

    Higham, Nicholas J.; Schreiber, Robert S.

    1988-01-01

    The polar decomposition of an m x n matrix A of full rank, where m is greater than or equal to n, can be computed using a quadratically convergent algorithm. The algorithm is based on a Newton iteration involving a matrix inverse. With the use of a preliminary complete orthogonal decomposition the algorithm can be extended to arbitrary A. How to use the algorithm to compute the positive semi-definite square root of a Hermitian positive semi-definite matrix is described. A hybrid algorithm which adaptively switches from the matrix inversion based iteration to a matrix multiplication based iteration due to Kovarik, and to Bjorck and Bowie is formulated. The decision when to switch is made using a condition estimator. This matrix multiplication rich algorithm is shown to be more efficient on machines for which matrix multiplication can be executed 1.5 times faster than matrix inversion.

  6. Preparation of mesoporous zirconia microspheres as inert matrix

    NASA Astrophysics Data System (ADS)

    Guo, Ting; Wang, Chen; Lv, Jinlong; Liang, Tongxiang

    2016-12-01

    Mesoporous zirconia microspheres, with a diameter of 900 μm, were prepared as an inert accelerator driven system (ADS) transmutation element matrix by the sol-gel method. The purpose of mesopores is to improve the adsorption capacity of inert matrix fuel (IMF) for minor actinides. The study indicated that the mesoporous zirconia performance was improved after the microspheres were hydrothermally treated at 150 °C, the specific surface area increased from 28.29 m2/g to 61.28 m2/g, and hydrothermal treatment avoided the cracking of the microspheres. Pre-decomposition of the organics during the hydrothermal process stabilized the mesoporous structure. The average pore diameter of mesoporous microsphere was 14.3 nm.

  7. The Software Maturity Matrix: A Software Performance Metric

    DTIC Science & Technology

    2003-01-28

    S e r v i c e - E x c e l l e n c e Overview n Introduction n Software Metrics n Software Maturity Matrix ( SwMM ) n SwMM Relationship to CMM...Development Team As of: 12I n t e g r i t y - S e r v i c e - E x c e l l e n c e Software Maturity Matrix ( SwMM ) n Purpose n Description n Evolution n...Implementation As of: 13I n t e g r i t y - S e r v i c e - E x c e l l e n c e SwMM Purpose n Forces Developer Requirements Capture (User

  8. Anisotropic Damage Mechanics Modeling in Metal Matrix Composites

    DTIC Science & Technology

    1993-05-15

    conducted on a titanium aluminide SiC-reinforced metal matrix composite. Center-cracked plates with laminate layups of (0/90) and (±45). were tested...Kattan, P. I., "Finite Strain Plasticity and Damage in Constitutive Modeling of Metals with Spin Tensors," Applied Mechanics Reviews, Vol. 45, No. 3...34Contractors Meeting on Mechanics of Materials," Dayton, Ohio, October 1991. Voyiadjis, G. Z., and Kattan, P. I., "Finite Strain Plasticity and Damage in

  9. Centrifugal casting of metal matrix composites. Ph.D. Thesis

    SciTech Connect

    Berger, R.E.

    1994-01-01

    Metal matrix composites (MMCs) have excellent properties and low material costs, but high manufacturing costs. The primary difficulty in manufacturing MMCs is in forming a tight matrix/reinforcement bond. This dissertation investigates improving the matrix/reinforcement bond through the use of high centrifugal forces. High centrifugal forces promote fiber infiltration (or particle submergence), remove gas voids, and resist particle pushing by the solidification front. Several aluminum matrix MMC samples are formed at up to 2,660 g`s. The project involves: (1) design and construction of a rotating crucible capable of a 690 C, 2,600 g-force environment; (2) a finite differences heat transfer model using an unique technique (spreadsheet iteration) which has application to engineering teaching and simple modeling problems; (3) a bubble buoyancy/surface adhesion analysis to predict maximum surface voids or bubble cling in cast materials; (4) a fluid surface tension effects analysis evaluating particle submergence into a melt, and melt infiltration into a porous media such as a fiber form; (5) creation of samples and direct visual measurement of void sizes in agreement with bubble buoyancy/surface adhesion theory; (6) performance of tests and direct evidence supporting the developed particle submergence/porous media infiltration theories; and (7) creation of samples and direct measurement of material strength under subjection to bending stress. The final conclusion is that use of high centrifugal forces in MMC manufacturing has potential, however it is only useful for large diameter fibers or particles (on the order of 200 micron) and relatively high g-forces (on the order of 2,500 g`s).

  10. Calculating weak matrix elements using HYP staggered fermions

    SciTech Connect

    T. Bhattacharya; G. T. Fleming; G. Kilcup; R. Gupta; W. Lee; S. Sharpe

    2004-03-01

    We present preliminary results of weak matrix elements relevant to CP violation calculated using the HYP (II) staggered fermions. Since the complete set of matching coefficients at the one-loop level became available recently, we have constructed lattice operators with all the g{sup 2} corrections included. The main results include both {Delta}I = 3/2 and {Delta}I = 1/2 contributions.

  11. Magnesium Matrix Composite Foams-Density, Mechanical Properties, and Applications

    DTIC Science & Technology

    2012-07-24

    known that the effect of particle-matrix interfacial bonding is much less significant under compression compared to under tension [33,34]. One of the...parameter). Some syntactic foam composites are found to have less than 0.4 g/cc density in Figure 9. These data points belong to foams that contain...syntactic foams containing porosity only inside hollow particles. The yield strength values for various types of MMSFs, including aluminum, titanium , and

  12. Metal-matrix composites: Status and prospects

    NASA Technical Reports Server (NTRS)

    1974-01-01

    Applications of metal matrix composites for air frames and jet engine components are discussed. The current state of the art in primary and secondary fabrication is presented. The present and projected costs were analyzed to determine the cost effectiveness of metal matrix composites. The various types of metal matrix composites and their characteristics are described.

  13. PAI-1 -675 4G/5G polymorphism as a prognostic biomarker in breast cancer.

    PubMed

    Lei, Haixin; Hemminki, Kari; Johansson, Robert; Altieri, Andrea; Enquist, Kerstin; Henriksson, Roger; Lenner, Per; Försti, Asta

    2008-05-01

    Extracellular matrix degradation, mediated by the urokinase plasminogen activation (uPA) system, is a critical step in tumor invasion and metastasis. High tumor levels of uPA and its inhibitor PAI-1 have been correlated with poor prognosis in breast cancer. We examined whether genetic variation in the genes of the uPA system affect breast cancer susceptibility and prognosis. We genotyped eight potentially functional single nucleotide polymorphisms (SNPs) in six genes of the uPA system in 959 Swedish breast cancer patients with detailed clinical data and up to 15 years of follow-up together with 952 matched controls. We used the unconditional logistic regression models to evaluate the associations between genotypes and breast cancer risk and tumor characteristics. The Kaplan-Meier method was used to estimate the survival probabilities; the log-rank test was used to test differences between subgroups. None of the SNPs conferred an increased breast cancer risk, but correlation with some traditional prognostic factors was observed for several SNPs. Most importantly, we identified the -675 4G/5G SNP in the PAI-1 gene as a promising prognostic biomarker for breast cancer. Compared to the 4G/4G and 4G/5G genotypes 5G/5G homozygosity correlated significantly with worse survival (RR 2.04, 95% CI 1.45-2.86, P<0.001), especially in patients with more aggressive tumors. 5G/5G homozygotes were also the group with worse survival among lymph node negative cases. Our finding suggests that genotyping PAI-1 -675 4G/5G may help in clinical prognosis of breast cancer.

  14. Teaching Tip: When a Matrix and Its Inverse Are Stochastic

    ERIC Educational Resources Information Center

    Ding, J.; Rhee, N. H.

    2013-01-01

    A stochastic matrix is a square matrix with nonnegative entries and row sums 1. The simplest example is a permutation matrix, whose rows permute the rows of an identity matrix. A permutation matrix and its inverse are both stochastic. We prove the converse, that is, if a matrix and its inverse are both stochastic, then it is a permutation matrix.

  15. Geothermal district G1

    SciTech Connect

    Not Available

    1988-12-01

    Geothermal District G1 includes 37 northeastern California counties and six geothermal fields: Lake City, Susanville, Litchfield, Wendel, Amedee, and Casa Diablo. Electrical generation from geothermal resources occurs in three of the fields: Wendel, Amedee, and Casa Diablo. Low-temperature geothermal projects are underway throughout the district and are described in a road log format. The ten projects described are located at Big Bend, Glass Mountain, Bieber, Alturas, Cedarville, Lake City, Honey Lake Valley, Greenville, and in Sierra and Mono Counties.

  16. Open G2 strings

    NASA Astrophysics Data System (ADS)

    de Boer, Jan; de Medeiros, Paul; El-Showk, Sheer; Sinkovics, Annamaria

    2008-02-01

    We consider an open string version of the topological twist previously proposed for sigma-models with G2 target spaces. We determine the cohomology of open strings states and relate these to geometric deformations of calibrated submanifolds and to flat or anti-self-dual connections on such submanifolds. On associative three-cycles we show that the worldvolume theory is a gauge-fixed Chern-Simons theory coupled to normal deformations of the cycle. For coassociative four-cycles we find a functional that extremizes on anti-self-dual gauge fields. A brane wrapping the whole G2 induces a seven-dimensional associative Chern-Simons theory on the manifold. This theory has already been proposed by Donaldson and Thomas as the higher-dimensional generalization of real Chern-Simons theory. When the G2 manifold has the structure of a Calabi-Yau times a circle, these theories reduce to a combination of the open A-model on special Lagrangians and the open B + B-bar-model on holomorphic submanifolds. We also comment on possible applications of our results.

  17. UPSS and G2

    NASA Technical Reports Server (NTRS)

    Dito, Scott J.

    2014-01-01

    The Universal Propellant Servicing System (UPSS) is a dedicated mobile launcher propellant delivery method that will minimize danger and complexity in order to allow vehicles to be serviced and ultimately launched from a variety of locations previously not seen fit for space launch. The UPPS/G2 project is the development of a model, simulation, and ultimately a working application that will control and monitor the cryogenic fluid delivery to the rocket for testing purposes. To accomplish this, the project is using the programming language/environment Gensym G2. The environment is an all-inclusive application that allows development, testing, modeling, and finally operation of the unique application through graphical and programmatic methods. We have learned G2 through classes and trial-and-error, and are now in the process of building the application that will soon be able to be tested on apparatuses here at Kennedy Space Center, and eventually on the actual unit. The UPSS will bring near-autonomous control of launches to those that need it, as well it will be a great addition to NASA and KSC's operational viability and the opportunity to bring space launches to parts of the world, and in time constraints, once not thought possible.

  18. Thermodynamics of protein folding: a random matrix formulation.

    PubMed

    Shukla, Pragya

    2010-10-20

    The process of protein folding from an unfolded state to a biologically active, folded conformation is governed by many parameters, e.g. the sequence of amino acids, intermolecular interactions, the solvent, temperature and chaperon molecules. Our study, based on random matrix modeling of the interactions, shows, however, that the evolution of the statistical measures, e.g. Gibbs free energy, heat capacity, and entropy, is single parametric. The information can explain the selection of specific folding pathways from an infinite number of possible ways as well as other folding characteristics observed in computer simulation studies.

  19. Fiber-matrix interface failures

    NASA Technical Reports Server (NTRS)

    Rabenberg, Lew; Marcus, Harris L.; Park, Hun Sub; Zong, Gui Sheng; Brown, Lloyd D.

    1989-01-01

    Interface fractures of aluminum-graphite composites under transverse loading are expected to occur within the graphite fibers, but very near the interface. Residual stresses in aluminum, reinforced with the new high modulus pitch-based fibers, are much lower than would be expected based on simple elasticity calculations. The excess stress may be relaxed by shearing internal to the fibers or at the interface rather than by plastic flow of the matrix. The internal shearing also occurs during repeated thermal cycling of these composites; the fibers are repeatedly intruded, then extruded, during repeated temperature excursions.

  20. Matrix management for aerospace 2000

    NASA Technical Reports Server (NTRS)

    Mccarthy, J. F., Jr.

    1980-01-01

    The martix management approach to program management is an organized effort for attaining program objectives by defining and structuring all elements so as to form a single system whose parts are united by interaction. The objective of the systems approach is uncompromisingly complete coverage of the program management endeavor. Starting with an analysis of the functions necessary to carry out a given program, a model must be defined; a matrix of responsibility assignment must be prepared; and each operational process must be examined to establish how it is to be carried out and how it relates to all other processes.

  1. Diffusive dynamics on paper matrix

    NASA Astrophysics Data System (ADS)

    Chaudhury, Kaustav; Kar, Shantimoy; Chakraborty, Suman

    2016-11-01

    Writing with ink on a paper and the rapid diagnostics of diseases using paper cartridge, despite their remarkable diversities from application perspective, both involve the motion of a liquid from a source on a porous hydrophilic substrate. Here we bring out a generalization in the pertinent dynamics by appealing to the concerned ensemble-averaged transport with reference to the underlying molecular picture. Our results reveal that notwithstanding the associated complexities and diversities, the resultant liquid transport characteristics on a paper matrix, in a wide variety of applications, resemble universal diffusive dynamics. Agreement with experimental results from diversified applications is generic and validates our unified theory.

  2. Random matrix theory within superstatistics.

    PubMed

    Abul-Magd, A Y

    2005-12-01

    We propose a generalization of the random matrix theory following the basic prescription of the recently suggested concept of superstatistics. Spectral characteristics of systems with mixed regular-chaotic dynamics are expressed as weighted averages of the corresponding quantities in the standard theory assuming that the mean level spacing itself is a stochastic variable. We illustrate the method by calculating the level density, the nearest-neighbor-spacing distributions, and the two-level correlation functions for systems in transition from order to chaos. The calculated spacing distribution fits the resonance statistics of random binary networks obtained in a recent numerical experiment.

  3. Neonatal disorders of germinal matrix.

    PubMed

    Raets, M M A; Dudink, J; Govaert, P

    2015-11-01

    The germinal matrix (GM) is a richly vascularized, transient layer near the ventricles. It produces neurons and glial cells, and is present in the foetal brain between 8 and 36 weeks of gestation. At 25 weeks, it reaches its maximum volume and subsequently withers. The GM is vulnerable to haemorrhage in preterm infants. This selective vulnerability is explained by limited astrocyte end-feet coverage of microvessels, reduced expression of fibronectin and immature tight junctions. Focal lesions in the neonatal period include haemorrhage, germinolysis and stroke. Such lesions in transient layers interrupt normal brain maturation and induce neurodevelopmental sequelae.

  4. The q-Laguerre matrix polynomials.

    PubMed

    Salem, Ahmed

    2016-01-01

    The Laguerre polynomials have been extended to Laguerre matrix polynomials by means of studying certain second-order matrix differential equation. In this paper, certain second-order matrix q-difference equation is investigated and solved. Its solution gives a generalized of the q-Laguerre polynomials in matrix variable. Four generating functions of this matrix polynomials are investigated. Two slightly different explicit forms are introduced. Three-term recurrence relation, Rodrigues-type formula and the q-orthogonality property are given.

  5. Preliminary characterisation of new glass reference materials (GSA-1G, GSC-1G, GSD-1G and GSE-1G) by laser ablation-inductively coupled plasma-mass spectrometry using 193 nm, 213 nm and 266 nm wavelengths

    USGS Publications Warehouse

    Guillong, M.; Hametner, K.; Reusser, E.; Wilson, S.A.; Gunther, D.

    2005-01-01

    New glass reference materials GSA-1G, GSC-1G, GSD-1G and GSE-1G have been characterised using a prototype solid state laser ablation system capable of producing wavelengths of 193 nm, 213 nm and 266 nm. This system allowed comparison of the effects of different laser wavelengths under nearly identical ablation and ICP operating conditions. The wavelengths 213 nm and 266 nm were also used at higher energy densities to evaluate the influence of energy density on quantitative analysis. In addition, the glass reference materials were analysed using commercially available 266 nm Nd:YAG and 193 nm ArF excimer lasers. Laser ablation analysis was carried out using both single spot and scanning mode ablation. Using laser ablation ICP-MS, concentrations of fifty-eight elements were determined with external calibration to the NIST SRM 610 glass reference material. Instead of applying the more common internal standardisation procedure, the total concentration of all element oxide concentrations was normalised to 100%. Major element concentrations were compared with those determined by electron microprobe. In addition to NIST SRM 610 for external calibration, USGS BCR-2G was used as a more closely matrix-matched reference material in order to compare the effect of matrix-matched and non matrix-matched calibration on quantitative analysis. The results show that the various laser wavelengths and energy densities applied produced similar results, with the exception of scanning mode ablation at 266 nm without matrix-matched calibration where deviations up to 60% from the average were found. However, results acquired using a scanning mode with a matrix-matched calibration agreed with results obtained by spot analysis. The increased abundance of large particles produced when using a scanning ablation mode with NIST SRM 610, is responsible for elemental fractionation effects caused by incomplete vaporisation of large particles in the ICP.

  6. On matrix Painlevé hierarchies

    NASA Astrophysics Data System (ADS)

    Gordoa, P. R.; Pickering, A.; Zhu, Z. N.

    2016-07-01

    We define a matrix first Painlevé hierarchy and a matrix second Painlevé (PII) hierarchy. For our matrix PII hierarchy we also give auto-Bäcklund transformations and consider the iteration of solutions. This is the first paper to define matrix Painlevé hierarchies and to give auto-Bäcklund transformations for a matrix Painlevé hierarchy. We also consider, amongst other results, the derivation of sequences of special integrals and autonomous limits. Until now it has been unknown how to connect the known matrix PII equation to the obvious candidates for related completely integrable matrix partial differential equations. Our matrix PII hierarchy is placed firmly within the context of a matrix modified Korteweg-de Vries (mKdV) hierarchy. In deriving our matrix PII hierarchy we make use of the Hamiltonian structure of this matrix mKdV hierarchy. We thus see once again the importance for Painlevé hierarchies of the integrability structures of related completely integrable equations.

  7. Matrix stiffening promotes a tumor vasculature phenotype

    PubMed Central

    Bordeleau, Francois; Mason, Brooke N.; Lollis, Emmanuel Macklin; Mazzola, Michael; Zanotelli, Matthew R.; Somasegar, Sahana; Califano, Joseph P.; Montague, Christine; LaValley, Danielle J.; Huynh, John; Mencia-Trinchant, Nuria; Negrón Abril, Yashira L.; Hassane, Duane C.; Bonassar, Lawrence J.; Butcher, Jonathan T.; Weiss, Robert S.; Reinhart-King, Cynthia A.

    2017-01-01

    Tumor microvasculature tends to be malformed, more permeable, and more tortuous than vessels in healthy tissue, effects that have been largely attributed to up-regulated VEGF expression. However, tumor tissue tends to stiffen during solid tumor progression, and tissue stiffness is known to alter cell behaviors including proliferation, migration, and cell–cell adhesion, which are all requisite for angiogenesis. Using in vitro, in vivo, and ex ovo models, we investigated the effects of matrix stiffness on vessel growth and integrity during angiogenesis. Our data indicate that angiogenic outgrowth, invasion, and neovessel branching increase with matrix cross-linking. These effects are caused by increased matrix stiffness independent of matrix density, because increased matrix density results in decreased angiogenesis. Notably, matrix stiffness up-regulates matrix metalloproteinase (MMP) activity, and inhibiting MMPs significantly reduces angiogenic outgrowth in stiffer cross-linked gels. To investigate the functional significance of altered endothelial cell behavior in response to matrix stiffness, we measured endothelial cell barrier function on substrates mimicking the stiffness of healthy and tumor tissue. Our data indicate that barrier function is impaired and the localization of vascular endothelial cadherin is altered as function of matrix stiffness. These results demonstrate that matrix stiffness, separately from matrix density, can alter vascular growth and integrity, mimicking the changes that exist in tumor vasculature. These data suggest that therapeutically targeting tumor stiffness or the endothelial cell response to tumor stiffening may help restore vessel structure, minimize metastasis, and aid in drug delivery. PMID:28034921

  8. Design, installation, and performance evaluation of a custom dye matrix standard for automated capillary electrophoresis.

    PubMed

    Cloete, Kevin Wesley; Ristow, Peter Gustav; Kasu, Mohaimin; D'Amato, Maria Eugenia

    2017-03-01

    CE equipment detects and deconvolutes mixtures containing up to six fluorescently labeled DNA fragments. This deconvolution is done by the collection software that requires a spectral calibration file. The calibration file is used to adjust for the overlap that occurs between the emission spectra of fluorescence dyes. All commercial genotyping and sequencing kits require the installation of a corresponding matrix standard to generate a calibration file. Due to the differences in emission spectrum overlap between fluorescent dyes, the application of existing commercial matrix standards to the electrophoretic separation of DNA labeled with other fluorescent dyes can yield undesirable results. Currently, the number of fluorescent dyes available for oligonucleotide labeling surpasses the availability of commercial matrix standards. Therefore, in this study we developed and evaluated a customized matrix standard using ATTO 633, ATTO 565, ATTO 550, ATTO Rho6G, and 6-FAM dyes for which no commercial matrix standard is available. We highlighted the potential genotyping errors of using an incorrect matrix standard by evaluating the relative performance of our custom dye set using six matrix standards. The specific performance of two genotyping kits (UniQTyper™ Y-10 version 1.0 and PowerPlex® Y23 System) was also evaluated using their specific matrix standards. The procedure we followed for the construction of our custom dye matrix standard can be extended to other fluorescent dyes.

  9. Statistical analysis of latent generalized correlation matrix estimation in transelliptical distribution

    PubMed Central

    Han, Fang; Liu, Han

    2016-01-01

    Correlation matrix plays a key role in many multivariate methods (e.g., graphical model estimation and factor analysis). The current state-of-the-art in estimating large correlation matrices focuses on the use of Pearson’s sample correlation matrix. Although Pearson’s sample correlation matrix enjoys various good properties under Gaussian models, its not an effective estimator when facing heavy-tail distributions with possible outliers. As a robust alternative, Han and Liu (2013b) advocated the use of a transformed version of the Kendall’s tau sample correlation matrix in estimating high dimensional latent generalized correlation matrix under the transelliptical distribution family (or elliptical copula). The transelliptical family assumes that after unspecified marginal monotone transformations, the data follow an elliptical distribution. In this paper, we study the theoretical properties of the Kendall’s tau sample correlation matrix and its transformed version proposed in Han and Liu (2013b) for estimating the population Kendall’s tau correlation matrix and the latent Pearson’s correlation matrix under both spectral and restricted spectral norms. With regard to the spectral norm, we highlight the role of “effective rank” in quantifying the rate of convergence. With regard to the restricted spectral norm, we for the first time present a “sign subgaussian condition” which is sufficient to guarantee that the rank-based correlation matrix estimator attains the optimal rate of convergence. In both cases, we do not need any moment condition.

  10. Uniform-burning matrix burner

    SciTech Connect

    Bohn, Mark S.; Anselmo, Mark

    2001-01-01

    Computer simulation was used in the development of an inward-burning, radial matrix gas burner and heat pipe heat exchanger. The burner and exchanger can be used to heat a Stirling engine on cloudy days when a solar dish, the normal source of heat, cannot be used. Geometrical requirements of the application forced the use of the inward burning approach, which presents difficulty in achieving a good flow distribution and air/fuel mixing. The present invention solved the problem by providing a plenum with just the right properties, which include good flow distribution and good air/fuel mixing with minimum residence time. CFD simulations were also used to help design the primary heat exchanger needed for this application which includes a plurality of pins emanating from the heat pipe. The system uses multiple inlet ports, an extended distance from the fuel inlet to the burner matrix, flow divider vanes, and a ring-shaped, porous grid to obtain a high-temperature uniform-heat radial burner. Ideal applications include dish/Stirling engines, steam reforming of hydrocarbons, glass working, and any process requiring high temperature heating of the outside surface of a cylindrical surface.

  11. Link prediction via matrix completion

    NASA Astrophysics Data System (ADS)

    Pech, Ratha; Hao, Dong; Pan, Liming; Cheng, Hong; Zhou, Tao

    2017-02-01

    Inspired by the practical importance of social networks, economic networks, biological networks and so on, studies on large and complex networks have attracted a surge of attention in the recent years. Link prediction is a fundamental issue to understand the mechanisms by which new links are added to the networks. We introduce the method of robust principal component analysis (robust PCA) into link prediction, and estimate the missing entries of the adjacency matrix. On the one hand, our algorithm is based on the sparse and low-rank property of the matrix, while, on the other hand, it also performs very well when the network is dense. This is because a relatively dense real network is also sparse in comparison to the complete graph. According to extensive experiments on real networks from disparate fields, when the target network is connected and sufficiently dense, whether it is weighted or unweighted, our method is demonstrated to be very effective and with prediction accuracy being considerably improved compared to many state-of-the-art algorithms.

  12. Extracellular Matrix and Liver Disease

    PubMed Central

    Arriazu, Elena; Ruiz de Galarreta, Marina; Cubero, Francisco Javier; Varela-Rey, Marta; Pérez de Obanos, María Pilar; Leung, Tung Ming; Lopategi, Aritz; Benedicto, Aitor; Abraham-Enachescu, Ioana

    2014-01-01

    Abstract Significance: The extracellular matrix (ECM) is a dynamic microenvironment that undergoes continuous remodeling, particularly during injury and wound healing. Chronic liver injury of many different etiologies such as viral hepatitis, alcohol abuse, drug-induced liver injury, obesity and insulin resistance, metabolic disorders, and autoimmune disease is characterized by excessive deposition of ECM proteins in response to persistent liver damage. Critical Issues: This review describes the main collagenous and noncollagenous components from the ECM that play a significant role in pathological matrix deposition during liver disease. We define how increased myofibroblasts (MF) from different origins are at the forefront of liver fibrosis and how liver cell-specific regulation of the complex scarring process occurs. Recent Advances: Particular attention is paid to the role of cytokines, growth factors, reactive oxygen species, and newly identified matricellular proteins in the regulation of fibrillar type I collagen, a field to which our laboratory has significantly contributed over the years. We compile data from recent literature on the potential mechanisms driving fibrosis resolution such as MF’ apoptosis, senescence, and reversal to quiescence. Future Directions: We conclude with a brief description of how epigenetics, an evolving field, can regulate the behavior of MF and of how new “omics” tools may advance our understanding of the mechanisms by which the fibrogenic response to liver injury occurs. Antioxid. Redox Signal. 21, 1078–1097. PMID:24219114

  13. Characterization of Metal Matrix Composites

    NASA Technical Reports Server (NTRS)

    Daniel, I. M.; Chun, H. J.; Karalekas, D.

    1994-01-01

    Experimental methods were developed, adapted, and applied to the characterization of a metal matrix composite system, namely, silicon carbide/aluminim (SCS-2/6061 Al), and its constituents. The silicon carbide fiber was characterized by determining its modulus, strength, and coefficient of thermal expansion. The aluminum matrix was characterized thermomechanically up to 399 C (750 F) at two strain rates. The unidirectional SiC/Al composite was characterized mechanically under longitudinal, transverse, and in-plane shear loading up to 399 C (750 F). Isothermal and non-isothermal creep behavior was also measured. The applicability of a proposed set of multifactor thermoviscoplastic nonlinear constitutive relations and a computer code was investigated. Agreement between predictions and experimental results was shown in a few cases. The elastoplastic thermomechanical behavior of the composite was also described by a number of new analytical models developed or adapted for the material system studied. These models include the rule of mixtures, composite cylinder model with various thermoelastoplastic analyses and a model based on average field theory. In most cases satisfactory agreement was demonstrated between analytical predictions and experimental results for the cases of stress-strain behavior and thermal deformation behavior at different temperatures. In addition, some models yielded detailed three-dimensional stress distributions in the constituents within the composite.

  14. Matrix metalloproteinases in metabolic syndrome.

    PubMed

    Hopps, E; Caimi, G

    2012-03-01

    Metabolic syndrome is commonly accompanied by an elevated cardiovascular risk with high morbidity and mortality. The alterations of the arterial vasculature begin with endothelial dysfunction and lead to micro- and macrovascular complications. The remodeling of the endothelial basal membrane, that promotes erosion and thrombosis, has a multifactorial pathogenesis that includes leukocyte activation, increased oxidative stress and also an altered matrix metalloproteinases (MMPs) expression. MMPs are endopeptidases which degrade extracellular matrix proteins, such as collagen, gelatins, fibronectin and laminin. They can be secreted by several cells within the vascular wall, but macrophages are determinant in the atherosclerotic plaques. Their activity is regulated by tissue inhibitors of MMP (TIMPs) and also by other molecules, such as plasmin. MMPs could be implicated in plaque instability predisposing to vascular complications. It has been demonstrated that an impaired MMP or TIMP expression is associated with higher risk of all-cause mortality. A large number of studies evaluated MMPs pattern in obesity, diabetes mellitus, arterial hypertension and dyslipidemia, all of which define metabolic syndrome according to several Consensus Statement (i.e. IDF, ATP III, AHA). However, few research have been carried out on subjects with metabolic syndrome. The evidences of an improvement in MMP/TIMP ratio with diet, exercise and medical therapy should encourage further investigations with the intent to contrast the atherosclerotic process and to reduce morbidity and mortality of this kind of patients.

  15. Reverse Watson-Crick G-G base pair in G-quadruplex formation.

    PubMed

    Mondal, Soma; Bhat, Jyotsna; Jana, Jagannath; Mukherjee, Meghomukta; Chatterjee, Subhrangsu

    2016-01-01

    A stable intermediate dimeric G-rich form as a precursor of tetrameric G-quadruplex structures has been detected via MALDI-TOF spectrometry. Molecular dynamics simulation offered detailed insights at the atomic level, assigning reverse Watson-Crick G-G base pairing (not Hoogsteen) in the G-rich dimer. In support of this, cisplatin formed a stable adduct by binding to the dimeric G-rich structure, eliminating the possibility of G-G Hoogsteen hydrogen bond formation.

  16. 7 CFR Exhibit G to Subpart G of... - [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 13 2010-01-01 2009-01-01 true G Exhibit G to Subpart G of Part 1940 Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE, RURAL BUSINESS-COOPERATIVE... REGULATIONS (CONTINUED) GENERAL Environmental Program Exhibit G to Subpart G of Part 1940...

  17. Automatic Generation of Partitioned Matrix Expressions for Matrix Operations

    NASA Astrophysics Data System (ADS)

    Fabregat-Traver, Diego; Bientinesi, Paolo

    2010-09-01

    We target the automatic generation of formally correct algorithms and routines for linear algebra operations. Given the broad variety of architectures and configurations with which scientists deal, there does not exist one algorithmic variant that is suitable for all scenarios. Therefore, we aim to generate a family of algorithmic variants to attain high-performance for a broad set of scenarios. One of the authors has previously demonstrated that automatic derivation of a family of algorithms is possible when the Partitioned Matrix Expression (PME) of the target operation is available. The PME is a recursive definition that states the relations between submatrices in the input and the output operands. In this paper we describe all the steps involved in the automatic derivation of PMEs, thus making progress towards a fully automated system.

  18. A Case of Extreme Simplicity of the Core Matrix in Three-Mode Principal Components Analysis.

    ERIC Educational Resources Information Center

    Murakami, Takashi; ten Berge, Jos M. F.; Kiers, Henk A. L.

    1998-01-01

    In three-mode principal components analysis, the P x Q x R core matrix "G" can be transformed to simple structure before it is interpreted. This paper shows that, when P=QR-1, G can be transformed to have nearly all the elements equal to values specified a priori. A closed-form solution for this transformation is offered. (SLD)

  19. Stability Analysis of Finite Difference Approximations to Hyperbolic Systems,and Problems in Applied and Computational Matrix and Operator Theory

    DTIC Science & Technology

    1990-12-07

    Technology, Haifa, 1968. 45 10. Bhatia , Rajendra , Perturbation Bounds for Matrix Eigenvalues, Pitman Research Notes in Mathematics, H. Brezis, R. G. Douglas...is currently in press in the SIAM Journal of Matrix Analysis . The proof sheets have been corrected and returned to the editor during the period of this...appear. [3] R. A. Horn and C. R. Johnson, Matrix Analysis , Cambridge University Press, New York, 1985. 141 M. Marcus and N. Khan, A note on the

  20. Two modulator generalized ellipsometer for complete mueller matrix measurement

    DOEpatents

    Jellison, Jr., Gerald E.; Modine, Frank A.

    1999-01-01

    A two-modulator generalized ellipsometer (2-MGE) comprising two polarizer-photoelastic modulator (PEM) pairs, an optical light source, an optical detection system, and associated data processing and control electronics, where the PEMs are free-running. The input light passes through the first polarizer-PEM pair, reflects off the sample surface or passes through the sample, passes through the second PEM-polarizer pair, and is detected. Each PEM is free running and operates at a different resonant frequency, e.g., 50 and 60 kHz. The resulting time-dependent waveform of the light intensity is a complicated function of time, and depends upon the exact operating frequency and phase of each PEM, the sample, and the azimuthal angles of the polarizer-PEM pairs, but can be resolved into a dc component and eight periodic components. In one embodiment, the waveform is analyzed using a new spectral analysis technique that is similar to Fourier analysis to determine eight sample Mueller matrix elements (normalized to the m.sub.00 Mueller matrix element). The other seven normalized elements of the general 4.times.4 Mueller matrix can be determined by changing the azimuthal angles of the PEM-polarizer pairs with respect to the plane of incidence. Since this instrument can measure all elements of the sample Mueller matrix, it is much more powerful than standard ellipsometers.

  1. General Matrix Inversion Technique for the Calibration of Electric Field Sensor Arrays on Aircraft Platforms

    NASA Technical Reports Server (NTRS)

    Mach, D. M.; Koshak, W. J.

    2007-01-01

    A matrix calibration procedure has been developed that uniquely relates the electric fields measured at the aircraft with the external vector electric field and net aircraft charge. The calibration method can be generalized to any reasonable combination of electric field measurements and aircraft. A calibration matrix is determined for each aircraft that represents the individual instrument responses to the external electric field. The aircraft geometry and configuration of field mills (FMs) uniquely define the matrix. The matrix can then be inverted to determine the external electric field and net aircraft charge from the FM outputs. A distinct advantage of the method is that if one or more FMs need to be eliminated or deemphasized [e.g., due to a malfunction), it is a simple matter to reinvert the matrix without the malfunctioning FMs. To demonstrate the calibration technique, data are presented from several aircraft programs (ER-2, DC-8, Altus, and Citation).

  2. Low G accelerometer testing

    NASA Technical Reports Server (NTRS)

    Vaughan, M. S.

    1972-01-01

    Eight different types of low-g accelerometer tests are covered on the Bell miniature electrostatically suspended accelerometer (MESA) which is known to be sensitive to less than 10 to the minus 7th power earth's gravity. These tests include a mass attracting scheme, Leitz dividing head, Wild theodolite, precision gage blocks, precision tiltmeters, Hilger Watts autocollimator, Razdow Mark 2 autocollimator, and laser interferometer measuring system. Each test is described and a comparison of the results is presented. The output of the MESA was as linear and consistent as any of the available devices were capable of measuring. Although the extent of agreement varied with the test equipment used, it can only be concluded that the indicated errors were attributable to the test equipment coupled with the environmental conditions.

  3. Superfund chemical data matrix, 1996

    SciTech Connect

    1996-06-01

    The Superfund Chemical Data Matrix (SCDM) is a source for factor values and benchmark values applied when evaluating potential National Priorities List (NPL) sites using the Hazard Ranking System. The HRS assigns factor values for toxicity, gas migration potential, gas and ground water mobility, surface water persistence, and bioaccumulation potential based on the physical, chemical, and radiological properties of hazardous substances present at a site. Hazardous substances, as defined for HRS purposes, are CERCLA hazardous substances plus CERCLA pollutants and contaminants. The HRS also assigns extra weight to targets with exposure levels to hazardous substances that are at or above benchmarks. These benchmarks include both risk-based screening concentrations and concentrations specified in regulatory limits for the hazardous substances present at a site for a particular migration pathway.

  4. Continuous analogues of matrix factorizations

    PubMed Central

    Townsend, Alex; Trefethen, Lloyd N.

    2015-01-01

    Analogues of singular value decomposition (SVD), QR, LU and Cholesky factorizations are presented for problems in which the usual discrete matrix is replaced by a ‘quasimatrix’, continuous in one dimension, or a ‘cmatrix’, continuous in both dimensions. Two challenges arise: the generalization of the notions of triangular structure and row and column pivoting to continuous variables (required in all cases except the SVD, and far from obvious), and the convergence of the infinite series that define the cmatrix factorizations. Our generalizations of triangularity and pivoting are based on a new notion of a ‘triangular quasimatrix’. Concerning convergence of the series, we prove theorems asserting convergence provided the functions involved are sufficiently smooth. PMID:25568618

  5. Evaluation of metal matrix composites

    NASA Technical Reports Server (NTRS)

    Okelly, K. P.

    1971-01-01

    The results of an evaluation of candidate metal-matrix composite materials for shuttle space radiators mounted to external structure are presented. The evaluation was specifically applicable to considerations of the manufacturing and properties of a potential space radiator. Two candidates, boron/aluminum and graphite/aluminum were obtained or made in various forms and tested in sufficient depth to allow selection of one of the two for future scale-up programs. The effort accomplished on this program verified that aluminum reinforced with boron was within the state-of-the-art in industry and possessed properties usable in the external skin areas available for shuttle radiators where re-entry temperatures will not exceed 800 F. It further demonstrated that graphite/aluminum has an apparently attractive future for space applications but requires extension development prior to scale-up.

  6. Thermoplastic matrix composite processing model

    NASA Technical Reports Server (NTRS)

    Dara, P. H.; Loos, A. C.

    1985-01-01

    The effects the processing parameters pressure, temperature, and time have on the quality of continuous graphite fiber reinforced thermoplastic matrix composites were quantitatively accessed by defining the extent to which intimate contact and bond formation has occurred at successive ply interfaces. Two models are presented predicting the extents to which the ply interfaces have achieved intimate contact and cohesive strength. The models are based on experimental observation of compression molded laminates and neat resin conditions, respectively. Identified as the mechanism explaining the phenomenon by which the plies bond to themselves is the theory of autohesion (or self diffusion). Theoretical predictions from the Reptation Theory between autohesive strength and contact time are used to explain the effects of the processing parameters on the observed experimental strengths. The application of a time-temperature relationship for autohesive strength predictions is evaluated. A viscoelastic compression molding model of a tow was developed to explain the phenomenon by which the prepreg ply interfaces develop intimate contact.

  7. Modified matrix volatilization setup for characterization of high purity germanium.

    PubMed

    Meruva, Adisesha Reddy; Raparthi, Shekhar; Kumar, Sunil Jai

    2016-01-01

    Modified matrix volatilization (MV) method has been described to characterize high purity germanium material of 7 N (99.99999%) purity. Transport of both, the chlorine gas generated in-situ in this method and the argon gas (carrier) is fine controlled by means of a mass flow controller. This enabled both uniform reaction of chlorine gas with the germanium matrix and smooth removal of germanium matrix as its chloride. This resulted in improvement in the reproducibility of the analytical results. The use of quartz reaction vessel has lead to the reduction in the process blank levels. The combined effect of these modifications in the MV setup has resulted in very consistent and low process blanks and hence improved detection limits of this method. Applicability of the method has been expanded to rare earth elements and other elements after examining their recoveries. The quantification is done by using inductively coupled plasma quadrupole mass spectrometer (ICP-QMS) and continuum source graphite furnace atomic absorption spectrometry (CS-GFAAS). In the absence of certified reference materials for high pure germanium, the accuracy of the method is established by spike recovery tests. The precision of the method has been found to vary from 1 to 30% for concentrations between 1 and 30 ng g(-1). The limits of detection (LOD) for the target analytes are found to be between 18 and 0.033 ng g(-1).

  8. Thermophysical and Electrical Properties of Metal Matrix Composites

    DTIC Science & Technology

    1979-12-01

    de if necessary and identify by block number) Aluminum matrix composiles, aluminum alloy matrix composites, copper matrix composites, electrical...the various com- posites of aluminum and aluminum alloy mar-tices, copper matrix, lead matrix, magnesium matrix, nickel and nickel alloy matrices...titanium and titanium alloy matrices, tungsten matrix, and zinc matrix. Most of the data are for aluminum DD j JAN 73 1473 EDITION OF I NOV6 S IS

  9. Fission Matrix Capability for MCNP Monte Carlo

    NASA Astrophysics Data System (ADS)

    Brown, Forrest; Carney, Sean; Kiedrowski, Brian; Martin, William

    2014-06-01

    We describe recent experience and results from implementing a fission matrix capability into the MCNP Monte Carlo code. The fission matrix can be used to provide estimates of the fundamental mode fission distribution, the dominance ratio, the eigenvalue spectrum, and higher mode forward and adjoint eigenfunctions of the fission neutron source distribution. It can also be used to accelerate the convergence of the power method iterations and to provide basis functions for higher-order perturbation theory. The higher-mode fission sources can be used in MCNP to determine higher-mode forward fluxes and tallies, and work is underway to provide higher-mode adjoint-weighted fluxes and tallies. Past difficulties and limitations of the fission matrix approach are overcome with a new sparse representation of the matrix, permitting much larger and more accurate fission matrix representations. The new fission matrix capabilities provide a significant advance in the state-of-the-art for Monte Carlo criticality calculations.

  10. Eigenvalues properties of terms correspondences matrix

    NASA Astrophysics Data System (ADS)

    Bondarchuk, Dmitry; Timofeeva, Galina

    2016-12-01

    Vector model representations of text documents are widely used in the intelligent search. In this approach a collection of documents is represented in the form of the term-document matrix, reflecting the frequency of terms. In the latent semantic analysis the dimension of the vector space is reduced by the singular value decomposition of the term-document matrix. Authors use a matrix of terms correspondences, reflecting the relationship between the terms, to allocate a semantic core and to obtain more simple presentation of the documents. With this approach, reducing the number of terms is based on the orthogonal decomposition of the matrix of terms correspondences. Properties of singular values of the term-document matrix and eigenvalues of the matrix of terms correspondences are studied in the case when documents differ substantially in length.

  11. Characterizing damage in ceramic matrix composites

    NASA Astrophysics Data System (ADS)

    Gyekenyesi, Andrew L.; Baker, Christopher; Morscher, Gregory

    2014-04-01

    With the upcoming implementation of ceramic matrix composites (CMCs) within aerospace systems (e.g., aviation turbine engines), an in-depth understanding of the failure process due to mechanical loads is required. This includes developing a basic understanding of the complex, multi-mechanism failure process as well as the associated nondestructive evaluation (NDE) techniques that are capable of recognizing and quantifying the damage. Various NDE techniques have been successfully utilized for assessing the damage state of woven CMCs, in particular, consisting of silicon carbide fibers and silicon carbide matrices (SiC/SiC). The multiple NDE techniques, studied by the authors of this paper, included acousto-ultrasonics, modal acoustic emissions, electrical resistance, impedance based structural health monitoring, pulsed thermography as well as thermoelastic stress analysis. The observed damage within the composites was introduced using multiple experimental tactics including uniaxial tensile tests, creep tests, and most recently, ballistic impact. This paper offers a brief review and summary of results for each of the applied NDE tools.

  12. Metal-Matrix/Hollow-Ceramic-Sphere Composites

    NASA Technical Reports Server (NTRS)

    Baker, Dean M.

    2011-01-01

    A family of metal/ceramic composite materials has been developed that are relatively inexpensive, lightweight alternatives to structural materials that are typified by beryllium, aluminum, and graphite/epoxy composites. These metal/ceramic composites were originally intended to replace beryllium (which is toxic and expensive) as a structural material for lightweight mirrors for aerospace applications. These materials also have potential utility in automotive and many other terrestrial applications in which there are requirements for lightweight materials that have high strengths and other tailorable properties as described below. The ceramic component of a material in this family consists of hollow ceramic spheres that have been formulated to be lightweight (0.5 g/cm3) and have high crush strength [40.80 ksi (.276.552 MPa)]. The hollow spheres are coated with a metal to enhance a specific performance . such as shielding against radiation (cosmic rays or x rays) or against electromagnetic interference at radio and lower frequencies, or a material to reduce the coefficient of thermal expansion (CTE) of the final composite material, and/or materials to mitigate any mismatch between the spheres and the matrix metal. Because of the high crush strength of the spheres, the initial composite workpiece can be forged or extruded into a high-strength part. The total time taken in processing from the raw ingredients to a finished part is typically 10 to 14 days depending on machining required.

  13. Water as a matrix for life

    NASA Technical Reports Server (NTRS)

    Pohorille, Andrew

    2005-01-01

    Life is based on non-covalent interactions. They might be either specific (enzyme-substrate interactions, selective ion transport) or nonspecific (lipid-lipid and lipid-protein interactions needed for membrane integrity, fusion and division). Their strength needs to be properly tuned, and this is mediated by the solvent. If interactions are too weak, there might be undesired response to natural fluctuations of physical and chemical parameters. If they are too strong it could impede kinetics and energetics of cellular processes. Thus, the solvent must allow for balancing these interactions. Physical and chemical properties of solvent provide strong constraints for life. Water exhibits a remarkable trait that it promotes both solvophobic and solvophilic interactions. Solvophobic interactions; related to high dielectric constant of the solvent) are necessary for self-organization of matter whereas solvophilic interactions are needed to ensure solubility of polar species. Water offers a large temperature domain of stable liquid and the characteristics hydrophobic effects are a consequence of the temperature in sensitivity of essential properties of its liquid state. Water, however, is not the only liquid with these favorable properties. I will compare in detail properties of water and other pure liquids or their mixtures that have a high dielectric constant and simultaneously support self-organization. I will also discuss properties of water that are unfavorable to life (e.g. its chemical activity against polymerization reactions) and close with summarizing what are alternatives to water as a matrix of life in space.

  14. Optical properties of matrix confined species

    NASA Astrophysics Data System (ADS)

    Lezhnina, M. M.; Kynast, U. H.

    2010-11-01

    A majority of optically functional materials can be perceived as a liaison between ionic or molecular guests and a more or less rigid host. The guests exhibit an optical function, whereas the host provides suitable space, both of them synergistically complementing each other. The embracement of guests and hosts is often very intimate, as e.g. in typical phosphors, where luminescent ions even become part of the host. While the host-guest terminology usually is not applied to such marriages, the term becomes appropriate, if the host grants some degrees of spatial freedom, yet giving order and structure to its guests. Zeolites, clays and inverse opals are porous materials naturally providing hospitable cavities, channels or other compartments, and at the same time the guests are often demanded to occupy preassigned positions within these, or to structurally adapt to the interior host topology. Whereas zeolites and clays are merely patient providers of guest space, inverse opals, can actively turn the light on and off. The present article summarises and highlights recent experimental evidence, ongoing research and some envisaged merits resulting from the interaction of matrix confined luminescent ions, complexes and molecules with a focus on the optical properties of rare earth based materials.

  15. Pericellular matrix formation alters the efficiency of intracellular uptake of oligonucleotides in osteosarcoma cells.

    PubMed

    Suzuki, Yoshitaka; Nishida, Yoshihiro; Naruse, Takahiro; Gemba, Takefumi; Ishiguro, Naoki

    2009-03-01

    One of the crucial roles of tumor extracellular matrix is to act as a barrier to drug delivery. In this study, we analyzed the relationship between the formation of tumor extracellular matrix and the efficiency of intracellular uptake of oligonucleotides in human osteosarcoma cell lines, HOS, and MG-63. Oligonucleotides used in this study were nuclear factor-kappa B (NF-kappaB) decoy, which might be a therapeutic tool for neoplasms. Pericellular matrix formation was examined by particle exclusion assay. Cellular uptake of fluorescein isothiocyanate-labeled NF-kappaB decoy was evaluated by fluorescent microscopy and flow cytometry. Effects of NF-kappaB decoy on cell viability and cell cycle arrest in MG-63 cells were determined by MTT assay and flow cytometry, respectively. MG-63 cells exhibited abundant pericellular matrix with time compared with HOS cells. Uptake of fluorescein isothiocyanate-labeled NF-kappaB decoy decreased in MG-63 cells with time but not in HOS cells in both monolayer and three-dimensional culture using matrigel. However, after enzymatic removal of pericellular matrix, the uptake markedly recovered in MG-63 cells. NF-kappaB decoy inhibited cell proliferation and induced G0/G1 cell cycle arrest in MG-63 cells. These results suggest that abundant pericellular matrix might disturb the uptake of NF-kappaB decoy, and modification of pericellular matrix composition would increase the efficacy of exogenous oligonucleotides treatment for neoplasms.

  16. Micromechanical Evaluation of Ceramic Matrix Composites

    DTIC Science & Technology

    1991-02-01

    Materials Sciences Corporation AD-A236 756 M.hM. 9 1 0513 IEIN HIfINU IIl- DTIC JUN 06 1991 MICROMECHANICAL EVALUATION OF S 0 CERAMIC MATRIX COMPOSITES C...Classification) \\() Micromechanical Evaluation of Ceramic Matrix Composites ) 12. PERSONAL AUTHOR(S) C-F. Yen, Z. Hashin, C. Laird, B.W. Rosen, Z. Wang 13a. TYPE...and strengthen the ceramic composites. In this task, various possibilities of crack propagation in unidirectional ceramic matrix composites under

  17. Rims, Matrix and the Bulk Compositions of Ordinary Chondrites

    NASA Astrophysics Data System (ADS)

    Alexander, C. M. O'd.

    1995-09-01

    endmember of the rim trend, matrix-like material must have been present during chondrule formation and was, perhaps, efficiently accreted by the chondrules. Two possible explanations for the Al enrichment of matrix are that it is rich either in refractory amorphous condensates or chondrule glass. If volatile losses of even only a few percent were common for chondrules during their formation, there is a third possible explanation. To a first approximation, the fractional mass loss rate of a chondritic particle during evaporation is inversely proportional to its radius. Thus, if the dust (1-10 micrometers) in the chondrule forming region experienced similar conditions to chondrules (100-1000 micrometers), evaporative losses from dust would have been severe. As a result, the dust would have been enriched in refractory elements like Al, perhaps explaining some of the fine-grained corundum and hibonite found in the CAI-poor OCs. If some of this dust was fractionated from the gas and chondrules before much recondensation took place and later mixed in with unprocessed material, the Al enrichment of matrix could be understood. Recondensation and subsequent redistribution in the parent body would explain alkali abundances in matrix. Secondary redistribution may have also produced the fractionation of many refractory elements from Al in UOC and CO3 rims and matrix [4]. The ordinary and enstatite chondrites have bulk compositions that indicate they lost a fraction of their refractory elements. This has always been explained as being due to the loss of refractory nebular condensates. However, evaporative residues of chondritic material can have very similar compositions to condensates. Consequently, if volatilization during chondrule formation was an important process and some of the finer grained material was lost prior to complete recondensation it may be possible to explain rim, matrix and bulk meteorite refractory and common lithophile compositions References: [1] Huss G. R. (1990

  18. Reconstituted asbestos matrix for fuel cells

    NASA Technical Reports Server (NTRS)

    Mcbryar, H.

    1975-01-01

    Method is described for reprocessing commercially available asbestos matrix stock to yield greater porosity and bubble pressure (due to increased surface tension), improved homogeneity, and greater uniformity.

  19. Matrix metalloproteinases in destructive lung disease.

    PubMed

    Houghton, A McGarry

    2015-01-01

    Matrix metalloproteinases (MMPs) play essential physiologic roles in numerous processes ranging from development to wound repair. Unfortunately, given the broad substrate specificity of the MMP family as a whole, aberrant degradation of extracellular matrix proteins can result in destructive disease. Emphysema, the result of destroyed lung elastin and collagen matrix, is the prototypical example of such a destructive process. More recent data has highlighted that MMPs play much more elaborate physiologic and pathophysiologic roles than simple matrix protein cleavage. Key pathophysiological roles for MMPs in emphysema will be discussed herein.

  20. Multiscale Modeling of Ceramic Matrix Composites

    NASA Technical Reports Server (NTRS)

    Bednarcyk, Brett A.; Mital, Subodh K.; Pineda, Evan J.; Arnold, Steven M.

    2015-01-01

    Results of multiscale modeling simulations of the nonlinear response of SiC/SiC ceramic matrix composites are reported, wherein the microstructure of the ceramic matrix is captured. This micro scale architecture, which contains free Si material as well as the SiC ceramic, is responsible for residual stresses that play an important role in the subsequent thermo-mechanical behavior of the SiC/SiC composite. Using the novel Multiscale Generalized Method of Cells recursive micromechanics theory, the microstructure of the matrix, as well as the microstructure of the composite (fiber and matrix) can be captured.

  1. SYMAT, COVAR: Test Procedures for Matrix Calculations

    NASA Technical Reports Server (NTRS)

    Morris, W. L.; Wiginton, C. L.; Lowell, D. K.

    1972-01-01

    The FORTRAN subroutine SYMAT and related subroutines are described. In essence SYMAT is an iterative algorithm in which the problem of finding eigenvalues and eigenvectors of a real symmetric matrix is transformed into an equivalent problem of finding eigenvalues and eigenvectors of an infinite sequence of matrices of order two. A DEMO PROGRAM contains a subroutine COVAR which is used to compute the covariance matrix (denoted by A) of a data matrix (denoted by X). Since a covariance matrix is symmetric it can be analyzed by using subroutine SYMAT.

  2. Stokes scattering matrix for human skin.

    PubMed

    Bhandari, Anak; Stamnes, Snorre; Hamre, Børge; Frette, Oyvind; Stamnes, Knut; Stamnes, Jakob J

    2012-11-01

    We use a layered model of normal human skin based on size distributions of polydisperse spherical particles and their complex refractive indices to compute the Stokes scattering matrix at wavelengths in the visible spectral band. The elements of the Stokes scattering matrix are required in a polarized radiative transfer code for a coupled air-tissue system to compute the polarized reflectance and examine how it is dependent on the vertical structure of the inherent optical properties of skin, including the phase matrix. Thus, the elements of the Stokes scattering matrix can be useful for investigating polarization-dependent light propagation in turbid optical media, such as human skin tissue.

  3. Finding Nonoverlapping Substructures of a Sparse Matrix

    SciTech Connect

    Pinar, Ali; Vassilevska, Virginia

    2005-08-11

    Many applications of scientific computing rely on computations on sparse matrices. The design of efficient implementations of sparse matrix kernels is crucial for the overall efficiency of these applications. Due to the high compute-to-memory ratio and irregular memory access patterns, the performance of sparse matrix kernels is often far away from the peak performance on a modern processor. Alternative data structures have been proposed, which split the original matrix A into A{sub d} and A{sub s}, so that A{sub d} contains all dense blocks of a specified size in the matrix, and A{sub s} contains the remaining entries. This enables the use of dense matrix kernels on the entries of A{sub d} producing better memory performance. In this work, we study the problem of finding a maximum number of nonoverlapping dense blocks in a sparse matrix, which is previously not studied in the sparse matrix community. We show that the maximum nonoverlapping dense blocks problem is NP-complete by using a reduction from the maximum independent set problem on cubic planar graphs. We also propose a 2/3-approximation algorithm that runs in linear time in the number of nonzeros in the matrix. This extended abstract focuses on our results for 2x2 dense blocks. However we show that our results can be generalized to arbitrary sized dense blocks, and many other oriented substructures, which can be exploited to improve the memory performance of sparse matrix operations.

  4. Method of making metal matrix composites reinforced with ceramic particulates

    DOEpatents

    Cornie, James A.; Kattamis, Theodoulos; Chambers, Brent V.; Bond, Bruce E.; Varela, Raul H.

    1989-01-01

    Composite materials and methods for making such materials are disclosed in which dispersed ceramic particles are at chemical equilibrium with a base metal matrix, thereby permitting such materials to be remelted and subsequently cast or otherwise processed to form net weight parts and other finished (or semi-finished) articles while maintaining the microstructure and mechanical properties (e.g. wear resistance or hardness) of the original composite. The composite materials of the present invention are composed of ceramic particles in a base metal matrix. The ceramics are preferably carbides of titanium, zirconium, tungsten, molybdenum or other refractory metals. The base metal can be iron, nickel, cobalt, chromium or other high temperature metal and alloys thereof. For ferrous matrices, alloys suitable for use as the base metal include cast iron, carbon steels, stainless steels and iron-based superalloys.

  5. Method of making metal matrix composites reinforced with ceramic particulates

    DOEpatents

    Cornie, J.A.; Kattamis, T.; Chambers, B.V.; Bond, B.E.; Varela, R.H.

    1989-08-01

    Composite materials and methods for making such materials are disclosed in which dispersed ceramic particles are at chemical equilibrium with a base metal matrix, thereby permitting such materials to be remelted and subsequently cast or otherwise processed to form net weight parts and other finished (or semi-finished) articles while maintaining the microstructure and mechanical properties (e.g. wear resistance or hardness) of the original composite. The composite materials of the present invention are composed of ceramic particles in a base metal matrix. The ceramics are preferably carbides of titanium, zirconium, tungsten, molybdenum or other refractory metals. The base metal can be iron, nickel, cobalt, chromium or other high temperature metal and alloys thereof. For ferrous matrices, alloys suitable for use as the base metal include cast iron, carbon steels, stainless steels and iron-based superalloys. 2 figs.

  6. Evaluating wilderness recreational opportunities: application of an impact matrix

    USGS Publications Warehouse

    Stohlgren, Thomas J.; Parsons, David J.

    1992-01-01

    An inventory of the severity and spatial distribution of wilderness campsite impacts in Sequoia and Kings Canyon National Parks identified a total of 273 distinct nodes of campsites or “management areas.” A campsite impact matrix was developed to evaluate management areas based on total impacts (correlated to the total area of campsite development) and the density, or concentration, of impacts relative to each area's potentially campable area. The matrix is used to quantify potential recreational opportunities for wilderness visitors in a spectrum from areas offering low impact-dispersed camping to those areas offering high impact-concentrated camping. Wilderness managers can use this type of information to evaluate use distribution patterns, identify areas to increase or decrease use, and to identify areas needing site-specific regulations (e.g., one-night camping limits) to preserve wilderness resources and guarantee outstanding opportunities for solitude.

  7. Calculation of transition matrix elements by nonsingular orbital transformations

    NASA Astrophysics Data System (ADS)

    Kývala, Mojmír

    A general strategy is described for the evaluation of transition matrix elements between pairs of full class CI wave functions built up from mutually nonorthogonal molecular orbitals. A new method is proposed for the counter-transformation of the linear expansion coefficients of a full CI wave function under a nonsingular transformation of the molecular-orbital basis. The method, which consists in a straightforward application of the Cauchy-Binet formula to the definition of a Slater determinant, is shown to be simple and suitable for efficient implementation on current high-performance computers. The new method appears mainly beneficial to the calculation of miscellaneous transition matrix elements among individually optimized CASSCF states and to the re-evaluation of the CASCI expansion coefficients in Slater-determinant bases formed from arbitrarily rotated (e.g., localized or, conversely, delocalized) active molecular orbitals.

  8. Grape seed extracts inhibit dentin matrix degradation by MMP-3

    PubMed Central

    Khaddam, Mayssam; Salmon, Benjamin; Le Denmat, Dominique; Tjaderhane, Leo; Menashi, Suzanne; Chaussain, Catherine; Rochefort, Gaël Y.; Boukpessi, Tchilalo

    2014-01-01

    Since Matrix metalloproteinases (MMPs) have been suggested to contribute to dentin caries progression, the hypothesis that MMP inhibition would affect the progression of dentin caries is clinically relevant. Grape seed extracts (GSE) have been previously reported to be natural inhibitors of MMPs. Objective: To evaluate the capacity of a GSE mouthrinse to prevent the degradation of demineralized dentin matrix by MMP-3 (stromelysin-1). Materials and Methods: Standardized blocks of dentin obtained from sound permanent teeth extracted for orthodontic reasons were demineralized with Ethylenediaminetetraacetic acid (EDTA) and pretreated either with (A) GSE (0.2% w/v), (B) amine fluoride (AmF) (20% w/v), (C) a mouthrinse which contains both, (D) placebo, (E) sodium fluoride (0.15 mg.ml−1), (F) PBS, (G) Chlorhexidine digluconate (CHX), or (H) zinc chloride (ZnCl2). The dentin blocks were then incubated with activated recombinant MMP-3. The supernatants were analyzed by Western Blot for several dentin matrix proteins known to be MMP-3 substrate. In parallel, scanning electron microscopy (SEM) was performed on resin replica of the dentin blocks. Results: Western blot analysis of the supernatants revealed that MMP-3 released from the dentin matrix small proteoglycans (decorin and biglycan) and dentin sialoprotein (DSP) in the AmF, sodium fluoride, PBS and placebo pretreated groups, but not in the GSE and mouthrinse pretreated groups. SEM examination of resin replica showed that the mouthrinse and its active components not only had an anti-MMP action but also modified the dentin surface accessibility. Conclusion: This study shows that GSE either alone or combined with AmF as in the evaluated mouthrinse limits dentin matrix degradation. This association may be promising to prevent the progression of caries within dentin. However, the procedure should be adapted to clinically relevant durations. PMID:25400590

  9. Conditional random matrix ensembles and the stability of dynamical systems

    NASA Astrophysics Data System (ADS)

    Kirk, Paul; Rolando, Delphine M. Y.; MacLean, Adam L.; Stumpf, Michael P. H.

    2015-08-01

    Random matrix theory (RMT) has found applications throughout physics and applied mathematics, in subject areas as diverse as communications networks, population dynamics, neuroscience, and models of the banking system. Many of these analyses exploit elegant analytical results, particularly the circular law and its extensions. In order to apply these results, assumptions must be made about the distribution of matrix elements. Here we demonstrate that the choice of matrix distribution is crucial. In particular, adopting an unrealistic matrix distribution for the sake of analytical tractability is liable to lead to misleading conclusions. We focus on the application of RMT to the long-standing, and at times fractious, ‘diversity-stability debate’, which is concerned with establishing whether large complex systems are likely to be stable. Early work (and subsequent elaborations) brought RMT to bear on the debate by modelling the entries of a system’s Jacobian matrix as independent and identically distributed (i.i.d.) random variables. These analyses were successful in yielding general results that were not tied to any specific system, but relied upon a restrictive i.i.d. assumption. Other studies took an opposing approach, seeking to elucidate general principles of stability through the analysis of specific systems. Here we develop a statistical framework that reconciles these two contrasting approaches. We use a range of illustrative dynamical systems examples to demonstrate that: (i) stability probability cannot be summarily deduced from any single property of the system (e.g. its diversity); and (ii) our assessment of stability depends on adequately capturing the details of the systems analysed. Failing to condition on the structure of dynamical systems will skew our analysis and can, even for very small systems, result in an unnecessarily pessimistic diagnosis of their stability.

  10. Bibliography on Ceramic Matrix Composites and Reinforcing Whiskers, Platelets, and Fibers, 1970-1990

    DTIC Science & Technology

    1993-08-01

    Pigott, G. H. Shalek, P D. Hurley, G F Pinto , P. J. Christiansen, D. E. Parkinson, W J J. Mater. Sci. Lett. Katz, J. D. 7 (4), 350-352, 1988 Metal Matrix...of Silicon Carbide-Silicon Carbide Materials Edited by A. R. Bunsell, Abbe, Francois Chermant, Jean -Louis P. Lamicq and A. Massiah J. Am. Ceram. Soc...Babonneau, Florence Livage, Jacques Zirconium Diboride and Tantalum Carbide Soraru, Gian D. Carturan. G Carbon Composites Mackenzie, J. D. Starrett, H

  11. Extracellular matrix proteins of dentine.

    PubMed

    Butler, W T; Ritchie, H H; Bronckers, A L

    1997-01-01

    Bone and dentine extracellular matrix proteins are similar, consisting primarily of type I collagen, acidic proteins and proteoglycans. Although collagen forms the lattice for deposition of calcium and phosphate for formation of carbonate apatite, the non-collagenous proteins are believed to control initiation and growth of the crystals. Despite this similarity, dentine contains three unique proteins apparently absent from bone and other tissue: dentine phosphophoryn (DPP), dentine matrix protein 1 (DMP1) and dentine sialoprotein (DSP). DPP and DMP1 are acidic phosphoproteins probably involved in the control of mineralization processes. DPP may localize in gap regions of collagen and initiate apatite crystal formation by binding large quantities of calcium in a conformation that promotes this process. Extensive studies have been conducted in our laboratory on the nature, biosynthesis, localization and gene structure of DSP. Immunolocalization studies showed that rat DSP, a 53 kDa sialic acid-rich glycoprotein, was synthesized by young and mature odontoblasts, and by dental pulp cells and pre-ameloblasts, but not by ameloblasts, osteoblasts, chondrocytes or other cell types. The cDNA sequence indicated that DSP was a 366-residue protein with several potential N-glycosylation sites, as well as phosphorylation sites, but that the amino acid sequence was dissimilar to that of other known proteins. Northern blot analysis detected several mRNA species near 4.6 and 1.5 kb, indicative of alternative splicing events. Evidence for two DSP genes was obtained, further complicating this picture. Recent in situ hybridization studies utilizing rat and mouse molars and incisors indicated that DSP mRNA was expressed by young odontoblasts and odontoblasts in animals of all ages. Transcripts were also observed in pre-ameloblasts. The expression of DSP mRNA ceased when these cells matured to become secretory ameloblasts. DSP transcripts were not detected in osteoblasts or other cell

  12. Improving photo-stability of conjugated polymer MEH-PPV embedded in solid matrices by purification of the matrix polymer

    NASA Astrophysics Data System (ADS)

    Tian, Yuxi; Sheinin, Vladimir; Kulikova, Olga; Mamardashvili, Nugzar; Scheblykin, Ivan G.

    2014-04-01

    For single molecule spectroscopy (SMS), molecules under study are usually immobilized in a polymer matrix e.g. poly(methyl methacrylate). We show a very significant improvement of the conjugated polymer MEH-PPV photo-stability and decrease of the luminescence impurities concentration when the matrix is purified. We identify benzoyl peroxide (a common radical initiator) as a possible oxidizing agent which residuals in the polymer matrix destroy MEH-PPV. These results show that purification and selection of a matrix obtained by radical-free synthetic technique are of great importance for SMS as well as other technologies using polymer matrices as hosts for light-emitting materials.

  13. Matrix metalloproteinases (MMPs), the main extracellular matrix (ECM) enzymes in collagen degradation, as a target for anticancer drugs.

    PubMed

    Jabłońska-Trypuć, Agata; Matejczyk, Marzena; Rosochacki, Stanisław

    2016-01-01

    The main group of enzymes responsible for the collagen and other protein degradation in extracellular matrix (ECM) are matrix metalloproteinases (MMPs). Collagen is the main structural component of connective tissue and its degradation is a very important process in the development, morphogenesis, tissue remodeling, and repair. Typical structure of MMPs consists of several distinct domains. MMP family can be divided into six groups: collagenases, gelatinases, stromelysins, matrilysins, membrane-type MMPs, and other non-classified MMPs. MMPs and their inhibitors have multiple biological functions in all stages of cancer development: from initiation to outgrowth of clinically relevant metastases and likewise in apoptosis and angiogenesis. MMPs and their inhibitors are extensively examined as potential anticancer drugs. MMP inhibitors can be divided into two main groups: synthetic and natural inhibitors. Selected synthetic inhibitors are in clinical trials on humans, e.g. synthetic peptides, non-peptidic molecules, chemically modified tetracyclines, and bisphosphonates. Natural MMP inhibitors are mainly isoflavonoids and shark cartilage.

  14. G-DYN Multibody Dynamics Engine

    NASA Technical Reports Server (NTRS)

    Acikmese, Behcet; Blackmore, James C.; Broderick, Daniel

    2011-01-01

    G-DYN is a multi-body dynamic simulation software engine that automatically assembles and integrates equations of motion for arbitrarily connected multibody dynamic systems. The algorithm behind G-DYN is based on a primal-dual formulation of the dynamics that captures the position and velocity vectors (primal variables) of each body and the interaction forces (dual variables) between bodies, which are particularly useful for control and estimation analysis and synthesis. It also takes full advantage of the spare matrix structure resulting from the system dynamics to numerically integrate the equations of motion efficiently. Furthermore, the dynamic model for each body can easily be replaced without re-deriving the overall equations of motion, and the assembly of the equations of motion is done automatically. G-DYN proved an essential software tool in the simulation of spacecraft systems used for small celestial body surface sampling, specifically in simulating touch-and-go (TAG) maneuvers of a robotic sampling system from a comet and asteroid. It is used extensively in validating mission concepts for small body sample return, such as Comet Odyssey and Galahad New Frontiers proposals.

  15. Richard G. Ewers

    NASA Technical Reports Server (NTRS)

    1998-01-01

    Richard G. (Dick) Ewers became a pilot in the Flight Crew Branch of NASA's Dryden Flight Research Center, Edwards, California, in May 1998. His flying duties focus on operation of the Airborne Science DC-8 and Systems Research F/A-18 aircraft, but he also maintains qualifications in the King Air and T-34C. He has more than 32 years and nearly 9,000 hours of military and civilian flight experience in all types of aircraft from jet fighters to blimps. Ewers came to NASA Dryden from a position as an engineering test pilot with Northrop Grumman's Electronic Sensors and Systems Division (formerly Westinghouse's Electronic Systems Group). He spent eight and a half years with Westinghouse flight testing radar and forward looking infrared systems under development for military and civilian use. Before going to work for Westinghouse, Ewers served for more than 21 years as a U.S. Marine Corps fighter and test pilot, flying F-4, A-4, and F/A-18 aircraft. He underwent flight training at Naval Air Station Pensacola, Fla., in 1969-70. He was subsequently assigned to both fighter/attack and reconnaissance squadrons before ultimately commanding an F-4S squadron for two years. Additionally, his flying included combat service in Vietnam and operational exchange tours with both U.S. Navy and U.S. Air Force squadrons flying F-4s around the world, including off aircraft carriers. Ewers graduated from the U.S. Naval Test Pilot School in 1981 and subsequently served two tours as a test pilot at the Naval Air Test Center, Patuxent River, Md. Most of his flight test experience was with the F/A-18 Hornet. He retired from the Marine Corps in 1989 with the rank of lieutenant colonel. Ewers graduated from the U.S. Air Force Academy in 1968 with a bachelor of science degree in engineering mechanics. He earned a master of science degree in aeronautical systems from the University of West Florida in 1970.

  16. Advanced Integration Matrix Education Outreach

    NASA Technical Reports Server (NTRS)

    Paul Heather L.

    2004-01-01

    The Advanced Integration Matrix (AIM) will design a ground-based test facility for developing revolutionary integrated systems for joint human-robotic missions in order to study and solve systems-level integration issues for exploration missions beyond Low Earth Orbit (LEO). This paper describes development plans for educational outreach activities related to technological and operational integration scenarios similar to the challenges that will be encountered through this project. The education outreach activities will provide hands-on, interactive exercises to allow students of all levels to experience design and operational challenges similar to what NASA deals with everyday in performing the integration of complex missions. These experiences will relate to and impact students everyday lives by demonstrating how their interests in science and engineering can develop into future careers, and reinforcing the concepts of teamwork and conflict resolution. Allowing students to experience and contribute to real-world development, research, and scientific studies of ground-based simulations for complex exploration missions will stimulate interest in the space program, and bring NASA's challenges to the student level. By enhancing existing educational programs and developing innovative activities and presentations, AIM will support NASA s endeavor to "inspire the next generation of explorers.. .as only NASA can."

  17. Clinical implications of matrix metalloproteinases.

    PubMed

    Mandal, Malay; Mandal, Amritlal; Das, Sudip; Chakraborti, Tapati; Sajal, Chakraborti

    2003-10-01

    Matrix metalloproteinases (MMPs) are a family of neutral proteinases that are important for normal development, wound healing, and a wide variety of pathological processes, including the spread of metastatic cancer cells, arthritic destruction of joints, atherosclerosis, pulmonary fibrosis, emphysema and neuroinflammation. In the central nervous system (CNS), MMPs have been shown to degrade components of the basal lamina, leading to disruption of the blood brain barrier and to contribute to the neuroinflammatory responses in many neurological diseases. Inhibition of MMPs have been shown to prevent progression of these diseases. Currently, certain MMP inhibitors have entered into clinical trials. A goal to the future should be to design selective synthetic inhibitors of MMPs that have minimum side effects. MMP inhibitors are designed in such a way that these can not only bind at the active site of the proteinases but also to have the characteristics to bind to other sites of MMPs which might be a promising route for therapy. To name a few: catechins, a component isolated from green tea; and Novastal, derived from extracts of shark cartilage are currently in clinical trials for the treatment of MMP-mediated diseases.

  18. The evolution of extracellular matrix.

    PubMed

    Ozbek, Suat; Balasubramanian, Prakash G; Chiquet-Ehrismann, Ruth; Tucker, Richard P; Adams, Josephine C

    2010-12-01

    We present a perspective on the molecular evolution of the extracellular matrix (ECM) in metazoa that draws on research publications and data from sequenced genomes and expressed sequence tag libraries. ECM components do not function in isolation, and the biological ECM system or "adhesome" also depends on posttranslational processing enzymes, cell surface receptors, and extracellular proteases. We focus principally on the adhesome of internal tissues and discuss its origins at the dawn of the metazoa and the expansion of complexity that occurred in the chordate lineage. The analyses demonstrate very high conservation of a core adhesome that apparently evolved in a major wave of innovation in conjunction with the origin of metazoa. Integrin, CD36, and certain domains predate the metazoa, and some ECM-related proteins are identified in choanoflagellates as predicted sequences. Modern deuterostomes and vertebrates have many novelties and elaborations of ECM as a result of domain shuffling, domain innovations and gene family expansions. Knowledge of the evolution of metazoan ECM is important for understanding how it is built as a system, its roles in normal tissues and disease processes, and has relevance for tissue engineering, the development of artificial organs, and the goals of synthetic biology.

  19. Channeled partial Mueller matrix polarimetry

    NASA Astrophysics Data System (ADS)

    Alenin, Andrey S.; Tyo, J. S.

    2015-09-01

    In prior work,1,2 we introduced methods to treat channeled systems in a way that is similar to Data Reduction Method (DRM), by focusing attention on the Fourier content of the measurement conditions. Introduction of Q enabled us to more readily extract the performance of the system and thereby optimize it to obtain reconstruction with the least noise. The analysis tools developed for that exercise can be expanded to be applicable to partial Mueller Matrix Polarimeters (pMMPs), which were a topic of prior discussion as well. In this treatment, we combine the principles involved in both of those research trajectories and identify a set of channeled pMMP families. As a result, the measurement structure of such systems is completely known and the design of a channeled pMMP intended for any given task becomes a search over a finite set of possibilities, with the additional channel rotation allowing for a more desirable Mueller element mixing.

  20. Scale-Dependent Fracture-Matrix Interactions And Their Impact on Radionuclide Transport - Final Report

    SciTech Connect

    Detwiler, Russell

    2014-06-30

    Matrix diffusion and adsorption within a rock matrix are widely regarded as important mechanisms for retarding the transport of radionuclides and other solutes in fractured rock (e.g., Neretnieks, 1980; Tang et al., 1981; Maloszewski and Zuber, 1985; Novakowski and Lapcevic, 1994; Jardine et al., 1999; Zhou and Xie, 2003; Reimus et al., 2003a,b). When remediation options are being evaluated for old sources of contamination, where a large fraction of contaminants reside within the rock matrix, slow diffusion out of the matrix greatly increases the difficulty and timeframe of remediation. Estimating the rates of solute exchange between fractures and the adjacent rock matrix is a critical factor in quantifying immobilization and/or remobilization of DOE-relevant contaminants within the subsurface. In principle, the most rigorous approach to modeling solute transport with fracture-matrix interaction would be based on local-scale coupled advection-diffusion/dispersion equations for the rock matrix and in discrete fractures that comprise the fracture network (Discrete Fracture Network and Matrix approach, hereinafter referred to as DFNM approach), fully resolving aperture variability in fractures and matrix property heterogeneity. However, such approaches are computationally demanding, and thus, many predictive models rely upon simplified models. These models typically idealize fracture rock masses as a single fracture or system of parallel fractures interacting with slabs of porous matrix or as a mobile-immobile or multi-rate mass transfer system. These idealizations provide tractable approaches for interpreting tracer tests and predicting contaminant mobility, but rely upon a fitted effective matrix diffusivity or mass-transfer coefficients. However, because these fitted parameters are based upon simplified conceptual models, their effectiveness at predicting long-term transport processes remains uncertain. Evidence of scale dependence of effective matrix diffusion

  1. Elevated expression of periostin in human osteoarthritic cartilage and its potential role in matrix degradation via matrix metalloproteinase-13

    PubMed Central

    Attur, Mukundan; Yang, Qing; Shimada, Kohei; Tachida, Yuki; Nagase, Hiroyuki; Mignatti, Paolo; Statman, Lauren; Palmer, Glyn; Kirsch, Thorsten; Beier, Frank; Abramson, Steven B.

    2015-01-01

    We investigated the role of periostin, an extracellular matrix protein, in the pathophysiology of osteoarthritis (OA). In OA, dysregulated gene expression and phenotypic changes in articular chondrocytes culminate in progressive loss of cartilage from the joint surface. The molecular mechanisms underlying this process are poorly understood. We examined periostin expression by immunohistochemical analysis of lesional and nonlesional cartilage from human and rodent OA knee cartilage. In addition, we used small interfering (si)RNA and adenovirus transduction of chondrocytes to knock down and up-regulate periostin levels, respectively, and analyzed its effect on matrix metalloproteinase (MMP)-13, a disintegrin and MMP with thrombospondin motifs (ADAMTS)-4, and type II collagen expression. We found high periostin levels in human and rodent OA cartilage. Periostin increased MMP-13 expression dose [1–10 µg/ml (EC50 0.5–1 μg/ml)] and time (24–72 h) dependently, significantly enhanced expression of ADAMTS4 mRNA, and promoted cartilage degeneration through collagen and proteoglycan degradation. Periostin induction of MMP-13 expression was inhibited by CCT031374 hydrobromide, an inhibitor of the canonical Wnt/β-catenin signaling pathway. In addition, siRNA-mediated knockdown of endogenous periostin blocked constitutive MMP-13 expression. These findings implicate periostin as a catabolic protein that promotes cartilage degeneration in OA by up-regulating MMP-13 through canonical Wnt signaling.—Attur, M., Yang, Q., Shimada, K., Tachida, Y., Nagase, H., Mignatti, P., Statman, L., Palmer, G., Kirsch, T., Beier, F., Abramson, A. B. Elevated expression of periostin in human osteoarthritic cartilage and its potential role in matrix degradation via matrix metalloproteinase-13. PMID:26092928

  2. Matrix model description of baryonic deformations

    SciTech Connect

    Bena, Iosif; Murayama, Hitoshi; Roiban, Radu; Tatar, Radu

    2003-03-13

    We investigate supersymmetric QCD with N{sub c} + 1 flavors using an extension of the recently proposed relation between gauge theories and matrix models.The impressive agreement between the two sides provides a beautiful confirmation of the extension of the gauge theory-matrix model relation to this case.

  3. Improvements in sparse matrix operations of NASTRAN

    NASA Technical Reports Server (NTRS)

    Harano, S.

    1980-01-01

    A "nontransmit" packing routine was added to NASTRAN to allow matrix data to be refered to directly from the input/output buffer. Use of the packing routine permits various routines for matrix handling to perform a direct reference to the input/output buffer if data addresses have once been received. The packing routine offers a buffer by buffer backspace feature for efficient backspacing in sequential access. Unlike a conventional backspacing that needs twice back record for a single read of one record (one column), this feature omits overlapping of READ operation and back record. It eliminates the necessity of writing, in decomposition of a symmetric matrix, of a portion of the matrix to its upper triangular matrix from the last to the first columns of the symmetric matrix, thus saving time for generating the upper triangular matrix. Only a lower triangular matrix must be written onto the secondary storage device, bringing 10 to 30% reduction in use of the disk space of the storage device.

  4. Finding nonoverlapping substructures of a sparse matrix

    SciTech Connect

    Pinar, Ali; Vassilevska, Virginia

    2004-08-09

    Many applications of scientific computing rely on computations on sparse matrices, thus the design of efficient implementations of sparse matrix kernels is crucial for the overall efficiency of these applications. Due to the high compute-to-memory ratio and irregular memory access patterns, the performance of sparse matrix kernels is often far away from the peak performance on a modern processor. Alternative data structures have been proposed, which split the original matrix A into A{sub d} and A{sub s}, so that A{sub d} contains all dense blocks of a specified size in the matrix, and A{sub s} contains the remaining entries. This enables the use of dense matrix kernels on the entries of A{sub d} producing better memory performance. In this work, we study the problem of finding a maximum number of non overlapping rectangular dense blocks in a sparse matrix, which has not been studied in the sparse matrix community. We show that the maximum non overlapping dense blocks problem is NP-complete by using a reduction from the maximum independent set problem on cubic planar graphs. We also propose a 2/3-approximation algorithm for 2 times 2 blocks that runs in linear time in the number of nonzeros in the matrix. We discuss alternatives to rectangular blocks such as diagonal blocks and cross blocks and present complexity analysis and approximation algorithms.

  5. The Molecules of the Cell Matrix.

    ERIC Educational Resources Information Center

    Weber, Klaus; Osborn, Mary

    1985-01-01

    Cytoplasmic proteins form a highly structured yet changeable matrix that affects cell shape, division, motion, and transport of vesicles and organelles. Types of microfilaments, research techniques, actin and myosin, tumor cells, and other topics are addressed. Evidence indicates that the cell matrix might have a bearing on metabolism. (DH)

  6. Multimedia Matrix: A Cognitive Strategy for Designers.

    ERIC Educational Resources Information Center

    Sherry, Annette C.

    This instructional development project evaluates the effect of a matrix-based strategy to assist multimedia authors in acquiring and applying principles for effective multimedia design. The Multimedia Matrix, based on the Park and Hannafin "Twenty Principles and Implications for Interactive Multimedia" design, displays a condensed…

  7. Risk Management using Dependency Stucture Matrix

    NASA Astrophysics Data System (ADS)

    Petković, Ivan

    2011-09-01

    An efficient method based on dependency structure matrix (DSM) analysis is given for ranking risks in a complex system or process whose entities are mutually dependent. This rank is determined according to the element's values of the unique positive eigenvector which corresponds to the matrix spectral radius modeling the considered engineering system. For demonstration, the risk problem of NASA's robotic spacecraft is analyzed.

  8. Block Hadamard measurement matrix with arbitrary dimension in compressed sensing

    NASA Astrophysics Data System (ADS)

    Liu, Shaoqiang; Yan, Xiaoyan; Fan, Xiaoping; Li, Fei; Xu, Wen

    2017-01-01

    As Hadamard measurement matrix cannot be used for compressing signals with dimension of a non-integral power-of-2, this paper proposes a construction method of block Hadamard measurement matrix with arbitrary dimension. According to the dimension N of signals to be measured, firstly, construct a set of Hadamard sub matrixes with different dimensions and make the sum of these dimensions equals to N. Then, arrange the Hadamard sub matrixes in a certain order to form a block diagonal matrix. Finally, take the former M rows of the block diagonal matrix as the measurement matrix. The proposed measurement matrix which retains the orthogonality of Hadamard matrix and sparsity of block diagonal matrix has highly sparse structure, simple hardware implements and general applicability. Simulation results show that the performance of our measurement matrix is better than Gaussian matrix, Logistic chaotic matrix, and Toeplitz matrix.

  9. The matrix exponential in transient structural analysis

    NASA Technical Reports Server (NTRS)

    Minnetyan, Levon

    1987-01-01

    The primary usefulness of the presented theory is in the ability to represent the effects of high frequency linear response with accuracy, without requiring very small time steps in the analysis of dynamic response. The matrix exponential contains a series approximation to the dynamic model. However, unlike the usual analysis procedure which truncates the high frequency response, the approximation in the exponential matrix solution is in the time domain. By truncating the series solution to the matrix exponential short, the solution is made inaccurate after a certain time. Yet, up to that time the solution is extremely accurate, including all high frequency effects. By taking finite time increments, the exponential matrix solution can compute the response very accurately. Use of the exponential matrix in structural dynamics is demonstrated by simulating the free vibration response of multi degree of freedom models of cantilever beams.

  10. Biocompatible 3D Matrix with Antimicrobial Properties.

    PubMed

    Ion, Alberto; Andronescu, Ecaterina; Rădulescu, Dragoș; Rădulescu, Marius; Iordache, Florin; Vasile, Bogdan Ștefan; Surdu, Adrian Vasile; Albu, Madalina Georgiana; Maniu, Horia; Chifiriuc, Mariana Carmen; Grumezescu, Alexandru Mihai; Holban, Alina Maria

    2016-01-20

    The aim of this study was to develop, characterize and assess the biological activity of a new regenerative 3D matrix with antimicrobial properties, based on collagen (COLL), hydroxyapatite (HAp), β-cyclodextrin (β-CD) and usnic acid (UA). The prepared 3D matrix was characterized by Scanning Electron Microscopy (SEM), Fourier Transform Infrared Microscopy (FT-IRM), Transmission Electron Microscopy (TEM), and X-ray Diffraction (XRD). In vitro qualitative and quantitative analyses performed on cultured diploid cells demonstrated that the 3D matrix is biocompatible, allowing the normal development and growth of MG-63 osteoblast-like cells and exhibited an antimicrobial effect, especially on the Staphylococcus aureus strain, explained by the particular higher inhibitory activity of usnic acid (UA) against Gram positive bacterial strains. Our data strongly recommend the obtained 3D matrix to be used as a successful alternative for the fabrication of three dimensional (3D) anti-infective regeneration matrix for bone tissue engineering.

  11. Fiber-matrix interfaces in ceramic composites

    SciTech Connect

    Besmann, T.M.; Stinton, D.P.; Kupp, E.R.; Shanmugham, S.; Liaw, P.K.

    1996-12-31

    The mechanical properties of ceramic matrix composites (CMCs) are governed by the relationships between the matrix, the interface material, and the fibers. In non-oxide matrix systems compliant pyrolytic carbon and BN have been demonstrated to be effective interface materials, allowing for absorption of mismatch stresses between fiber and matrix and offering a poorly bonded interface for crack deflection. The resulting materials have demonstrated remarkable strain/damage tolerance together with high strength. Carbon or BN, however, suffer from oxidative loss in many service environments, and thus there is a major search for oxidation resistant alternatives. This paper reviews the issues related to developing a stable and effective interface material for non-oxide matrix CMCs.

  12. Nuclear Matrix Proteins in Human Colon Cancer

    NASA Astrophysics Data System (ADS)

    Keesee, Susan K.; Meneghini, Marc D.; Szaro, Robert P.; Wu, Ying-Jye

    1994-03-01

    The nuclear matrix is the nonchromatin scaffolding of the nucleus. This structure confers nuclear shape, organizes chromatin, and appears to contain important regulatory proteins. Tissue specific nuclear matrix proteins have been found in the rat, mouse, and human. In this study we compared high-resolution two-dimensional gel electropherograms of nuclear matrix protein patterns found in human colon tumors with those from normal colon epithelia. Tumors were obtained from 18 patients undergoing partial colectomy for adenocarcinoma of the colon and compared with tissue from 10 normal colons. We have identified at least six proteins which were present in 18 of 18 colon tumors and 0 of 10 normal tissues, as well as four proteins present in 0 of 18 tumors and in 10 of 10 normal tissues. These data, which corroborate similar findings of cancer-specific nuclear matrix proteins in prostate and breast, suggest that nuclear matrix proteins may serve as important markers for at least some types of cancer.

  13. Google matrix analysis of the multiproduct world trade network

    NASA Astrophysics Data System (ADS)

    Ermann, Leonardo; Shepelyansky, Dima L.

    2015-04-01

    Using the United Nations COMTRADE database [United Nations Commodity Trade Statistics Database, available at: http://comtrade.un.org/db/. Accessed November (2014)] we construct the Google matrix G of multiproduct world trade between the UN countries and analyze the properties of trade flows on this network for years 1962-2010. This construction, based on Markov chains, treats all countries on equal democratic grounds independently of their richness and at the same time it considers the contributions of trade products proportionally to their trade volume. We consider the trade with 61 products for up to 227 countries. The obtained results show that the trade contribution of products is asymmetric: some of them are export oriented while others are import oriented even if the ranking by their trade volume is symmetric in respect to export and import after averaging over all world countries. The construction of the Google matrix allows to investigate the sensitivity of trade balance in respect to price variations of products, e.g. petroleum and gas, taking into account the world connectivity of trade links. The trade balance based on PageRank and CheiRank probabilities highlights the leading role of China and other BRICS countries in the world trade in recent years. We also show that the eigenstates of G with large eigenvalues select specific trade communities.

  14. MATRIX City: A Multi-Risk Platform

    NASA Astrophysics Data System (ADS)

    Euchner, F.; Mignan, A.

    2012-04-01

    MATRIX City (the MATRIX Common IT sYstem) is the computational platform that is being developed in the course of the New Multi-Hazard and Multi-Risk Assessment Methods for Europe (MATRIX) project. MATRIX aims to develop multi-type hazard and risk assessment and mitigation tools suited to the European context. The core of MATRIX City is a risk engine of a novel type that is based on a sequential simulation approach, which allows to quantify interactions and other time-dependent processes at the hazard, exposure, vulnerability and risk levels. For risk estimation in realistic scenarios, data availability is crucial. To overcome this limitation, MATRIX City provides a component called Virtual City. It is a collection of heuristic databases, which provides a generic approach to quantifying multi-type hazard and risk when data coverage is poor, and for sensitivity analysis. MATRIX City results are intended to provide a "big picture" of the expected impact of multi-type hazard and risk modelling (as opposed to static modelling), thus being a valuable tool for decision support. MATRIX City development uses a modern software engineering approach (test-driven development, continuous integration). The architecture is flexible, so that new perils, new models and large datasets can be accommodated easily. However, it should be noted that hazard computation is not part of MATRIX City. Hazard footprints have to be provided as input data, as well as exposure and vulnerability. The data model used in MATRIX City is an enhancement of the Natural hazards' Risk Markup Language (NRML). An XML serialization of this data model, which is a GML (Geographic Markup Language) application schema, is used for data interchange.

  15. Pseudoscalar glueball mass from η-η'-G mixing

    NASA Astrophysics Data System (ADS)

    Cheng, Hai-Yang; Li, Hsiang-Nan; Liu, Keh-Fei

    2009-01-01

    We deduce the mass of the pseudoscalar glueball G from an η-η'-G mixing formalism based on the anomalous Ward identity for transition matrix elements. With the inputs from the recent KLOE experiment, we find a solution for the pseudoscalar glueball mass around (1.4±0.1)GeV, which is fairly insensitive to a range of inputs with or without Okubo-Zweig-Iizuka-rule violating effects. This affirms that η(1405), having a large production rate in the radiative J/Ψ decay and not seen in γγ reactions, is indeed a leading candidate for the pseudoscalar glueball. Other relevant quantities including the anomaly and pseudoscalar density matrix elements are obtained. The decay widths for G→γγ, ℓ+ℓ- are also predicted.

  16. Towards G2G: Systems of Technology Database Systems

    NASA Technical Reports Server (NTRS)

    Maluf, David A.; Bell, David

    2005-01-01

    We present an approach and methodology for developing Government-to-Government (G2G) Systems of Technology Database Systems. G2G will deliver technologies for distributed and remote integration of technology data for internal use in analysis and planning as well as for external communications. G2G enables NASA managers, engineers, operational teams and information systems to "compose" technology roadmaps and plans by selecting, combining, extending, specializing and modifying components of technology database systems. G2G will interoperate information and knowledge that is distributed across organizational entities involved that is ideal for NASA future Exploration Enterprise. Key contributions of the G2G system will include the creation of an integrated approach to sustain effective management of technology investments that supports the ability of various technology database systems to be independently managed. The integration technology will comply with emerging open standards. Applications can thus be customized for local needs while enabling an integrated management of technology approach that serves the global needs of NASA. The G2G capabilities will use NASA s breakthrough in database "composition" and integration technology, will use and advance emerging open standards, and will use commercial information technologies to enable effective System of Technology Database systems.

  17. Sol/Gel Processing Techniques for Glass Matrix Composites.

    DTIC Science & Technology

    1987-11-01

    development of a general technique (i.e., Pyrex is less susceptible to devitrification than SiO2 or TiO2 -SiO 2 ). In addition. the properties of these sol / gel ...of a sol / gel process for SIC 2 and SiO2 - TiO2 - together with a data base for their densification - are prerequisite to the successful fabrication of...S~%ad~ 5~ ~ ~ *~~~~;:>;::L-; 1: ’*~~’~ ’S. AFWL-TN-86-59 AFWL-TN- 86-59 00 SOL / GEL PROCESSING TECHNIQUES FOR GLASS MATRIX COMPOSITES 0) C. G

  18. Hierarchical cluster analysis of matrix effects on 110 pesticide residues in 28 tea matrixes.

    PubMed

    Li, Yan; Pang, Guo-Fang; Fan, Chun-Lin; Chen, Xi

    2013-01-01

    Matrix effects on 110 pesticides in 28 tea matrixes of different varieties and origins by LC/MS/MS were studied, and most of the pesticides exhibited soft and medium signal suppression. To better understand the influence of the tea varieties and the physicochemical characteristics of pesticides on the matrix effects, the multivariate analysis tool called hierarchical cluster analysis was applied. Tea matrixes were grouped into three clusters: unfermented, fermented, and post-fermented teas. Any type of tea can be chosen from each cluster as a corresponding representative matrix within that cluster to make matrix-matched solutions, which could simplify analysis while guaranteeing its accuracy. Matrix effects on most pesticides were similar despite the physicochemical diversities of the pesticides.

  19. Modal acoustic emission source determination in silicon carbide matrix composites

    NASA Astrophysics Data System (ADS)

    Morscher, G. N.

    2000-05-01

    Modal acoustic emission has been used to monitor damage accumulation in woven silicon carbide (SiC) fiber reinforced SiC matrix composites during tensile testing. There are several potential sources of damage in these systems including transverse matrix cracking, fiber/matrix interphase debonding and sliding, longitudinal cracks in between plies, and fiber breakage. In the past, it has been shown that modal AE is excellent at detecting when damage occurs and subsides, where the damage occurs along the length of the sample, and the loss in material stiffness as a consequence of damage accumulation. The next step is to determine the extent that modal AE can be used to identify specific physical sources. This study will discuss the status of this aim for this composite system. Individual events were analyzed and correlated to specific sources based on the characteristics of the received waveforms, e.g., frequency spectrum and energy, and when the event occurred during the stress-history of the tensile test. Post-test microstructural examination of the test specimens enabled some correlation between specific types of AE events and damage sources.

  20. Decellularized bone matrix grafts for calvaria regeneration

    PubMed Central

    Lee, Dong Joon; Diachina, Shannon; Lee, Yan Ting; Zhao, Lixing; Zou, Rui; Tang, Na; Han, Han; Chen, Xin; Ko, Ching-Chang

    2016-01-01

    Decellularization is a promising new method to prepare natural matrices for tissue regeneration. Successful decellularization has been reported using various tissues including skin, tendon, and cartilage, though studies using hard tissue such as bone are lacking. In this study, we aimed to define the optimal experimental parameters to decellularize natural bone matrix using 0.5% sodium dodecyl sulfate and 0.1% NH4OH. Then, the effects of decellularized bone matrix on rat mesenchymal stem cell proliferation, osteogenic gene expression, and osteogenic differentiations in a two-dimensional culture system were investigated. Decellularized bone was also evaluated with regard to cytotoxicity, biochemical, and mechanical characteristics in vitro. Evidence of complete decellularization was shown through hematoxylin and eosin staining and DNA measurements. Decellularized bone matrix displayed a cytocompatible property, conserved structure, mechanical strength, and mineral content comparable to natural bone. To study new bone formation, implantation of decellularized bone matrix particles seeded with rat mesenchymal stem cells was conducted using an orthotopic in vivo model. After 3 months post-implantation into a critical-sized defect in rat calvaria, new bone was formed around decellularized bone matrix particles and also merged with new bone between decellularized bone matrix particles. New bone formation was analyzed with micro computed tomography, mineral apposition rate, and histomorphometry. Decellularized bone matrix stimulated mesenchymal stem cell proliferation and osteogenic differentiation in vitro and in vivo, achieving effective bone regeneration and thereby serving as a promising biological bone graft. PMID:28228929

  1. [Modern polymers in matrix tablets technology].

    PubMed

    Zimmer, Łukasz; Kasperek, Regina; Poleszak, Ewa

    2014-01-01

    Matrix tablets are the most popular method of oral drug administration, and polymeric materials have been used broadly in matrix formulations to modify and modulate drug release rate. The main goal of the system is to extend drug release profiles to maintain a constant in vivo plasma drug concentration and a consistent pharmacological effect. Polymeric matrix tablets offer a great potential as oral controlled drug delivery systems. Cellulose derivatives, like hydroxypropyl methylcellulose (HPMC) are often used as matrix formers. However, also other types of polymers can be used for this purpose including: Kollidon SR, acrylic acid polymers such as Eudragits and Carbopols. Nevertheless, polymers of natural origin like: carragens, chitosan and alginates widely used in the food and cosmetics industry are now coming to the fore of pharmaceutical research and are used in matrix tablets technology. Modern polymers allow to obtain matrix tablets by 3D printing, which enables to develop new formulation types. In this paper, the polymers used in matrix tablets technology and examples of their applications were described.

  2. Fabric analysis of Allende matrix using EBSD

    NASA Astrophysics Data System (ADS)

    Watt, Lauren E.; Bland, Phil A.; Prior, Dave J.; Russell, Sara S.

    Fabric analysis of the interstitial matrix material in primitive meteorites offers a novel window on asteroid formation and evolution. Electron backscatter diffraction (EBSD) has allowed fabrics in these fine-grained materials to be visualized in detail for the first time. Our data reveal that Allende, a CV3 chondrite, possesses a uniform, planar, short-axis alignment fabric that is pervasive on a broad scale and is probably the result of deformational shortening related to impact or gravitational compaction. Interference between this matrix fabric and the larger, more rigid components, such as dark inclusions (DIs) and calcium-aluminium-rich inclusions (CAIs), has lead to the development of locally oriented and intensified matrix fabrics. In addition, DIs possess fabrics that are conformable with the broader matrix fabric. These results suggest that DIs were in situ prior to the deformational shortening event responsible for these fabrics, thus providing an argument against dark inclusions being fragments from another lithified part of the asteroid (Kojima and Tomeoka 1996; Fruland et al. 1978). Moreover, both DIs and Allende matrix are highly porous (˜25%) (Corrigan et al. 1997). Mobilizing a highly porous DI during impact-induced brecciation without imposing a fabric and incorporating it into a highly porous matrix without significantly compacting these materials is improbable. We favor a model that involves Allende DIs, CAIs, and matrix accreting together and experiencing the same deformation events.

  3. 2-Adic clustering of the PAM matrix.

    PubMed

    Khrennikov, A Yu; Kozyrev, S V

    2009-12-07

    In this paper we demonstrate that the use of the system of 2-adic numbers provides a new insight to some problems of genetics, in particular, degeneracy of the genetic code and the structure of the PAM matrix in bioinformatics. The 2-adic distance is an ultrametric and applications of ultrametric in bioinformatics are not surprising. However, by using the 2-adic numbers we match ultrametric with a number theoretic structure. In this way we find new applications of an ultrametric which differ from known up to now in bioinformatics. We obtain the following results. We show that the PAM matrix A allows the expansion into the sum of the two matrices A=A((2))+A((infinity)), where the matrix A((2)) is 2-adically regular (i.e. matrix elements of this matrix are close to locally constant with respect to the discussed earlier by the authors 2-adic parametrization of the genetic code), and the matrix A((infinity)) is sparse. We discuss the structure of the matrix A((infinity)) in relation to the side chain properties of the corresponding amino acids. We introduce the family of substitution matrices A(alpha,beta)=alpha A((2))+beta A((infinity)), alpha,beta>or=0 which should allow to vary the alignment procedure in order to take into account the different chemical and geometric properties of the amino acids.

  4. Matrix metalloproteinase-2 promoter variability in psoriasis.

    PubMed

    Vasku, Vladimir; Bienertova Vasku, Julie; Slonková, Veronika; Kanková, Katerina; Vasku, Anna

    2009-07-01

    The expression of matrix metalloproteinase-2 was observed to be significantly upregulated in psoriasis. The aim of this study was to associate the DNA polymorphic variants in MMP-2 promoter gene with psoriasis and/or with psoriasis phenotypes related to psoriasis and comorbid heredity. In the total of 582 Czech Caucasian individuals (386 patients with psoriasis and 196 controls of similar age and sex distribution without personal or family history of chronic disease of the skin), four MMP-2 promoter polymorphisms (-1575G/A, -1306C/T, -790T/G and -735C/T) were detected by PCR methods. A significant association of GG genotype of -790 MMP-2 polymorphism with psoriasis was observed (Pcorr = 0.04). Although no significant case-control differences in frequency of associated GG(-1575)CC(-1306)TT(-790) MMP-2 promoter genotype were observed, the genotype was found to be significantly less frequent in patients with family history of psoriasis (close as well as distant), family history of diabetes and personal history of allergy (2/11 vs. 55/32, odds ratio (OR) for GGCCTT 0.11, 95% confidential interval 0.02-0.50, Pcorr = 0.01). The significant difference between psoriatic patients with positive anamnestic data on diabetes, psoriasis and allergy compared with psoriatic patients that have only positive family history of diabetes was also observed (2/11 vs. 38/31, P = 0.009, Pcorr = 0.04; OR 0.15, 95% CI = 0.03-0.72 for psoriatic patients with GGCCTT genotype and family history of psoriasis, diabetes and personal history of allergy). To conclude, the associated GGCCTT genotype in the promoter of MMP-2 gene was less frequent in patients with positive family history of psoriasis, diabetes and personal history of allergy compared with psoriatic patients without them (2/11 vs. 68/57, P = 0.007, Pcorr = 0.04; OR = 0.15, 95% CI = 0.03-0.72 for psoriatic patients with family history of psoriasis and diabetes and with allergy). Based on our results, we suggest that the MMP-2 located in

  5. Active Matrix OLED Test Report

    NASA Technical Reports Server (NTRS)

    Salazar, George

    2013-01-01

    This report focuses on the limited environmental testing of the AMOLED display performed as an engineering evaluation by The NASA Johnson Space Center (JSC)-specifically. EMI. Thermal Vac, and radiation tests. The AMOLED display is an active-matrix Organic Light Emitting Diode (OLED) technology. The testing provided an initial understanding of the technology and its suitability for space applications. Relative to light emitting diode (LED) displays or liquid crystal displays (LCDs), AMOLED displays provide a superior viewing experience even though they are much lighter and smaller, produce higher contrast ratio and richer colors, and require less power to operate than LCDs. However, AMOLED technology has not been demonstrated in a space environment. Therefore, some risks with the technology must be addressed before they can be seriously considered for human spaceflight. The environmental tests provided preliminary performance data on the ability of the display technology to handle some of the simulated induced space/spacecraft environments that an AMOLED display will see during a spacecraft certification test program. This engineering evaluation is part of a Space Act Agreement (SM) between The NASA/JSC and Honeywell International (HI) as a collaborative effort to evaluate the potential use of AMOLED technology for future human spaceflight missions- both government-led and commercial. Under this SM, HI is responsible for doing optical performance evaluation, as well as temperature and touch screen studies. The NASA/JSC is responsible for performing environmental testing comprised of EMI, Thermal Vac, and radiation tests. Additionally, as part of the testing, limited optical data was acquired to assess performance as the display was subjected to the induced environments. The NASA will benefit from this engineering evaluation by understanding AMOLED suitability for future use in space as well as becoming a smarter buyer (or developer) of the technology. HI benefits

  6. The diversity of shell matrix proteins: genome-wide investigation of the pearl oyster, Pinctada fucata.

    PubMed

    Miyamoto, Hiroshi; Endo, Hirotoshi; Hashimoto, Naoki; Limura, Kurin; Isowa, Yukinobu; Kinoshita, Shigeharu; Kotaki, Tomohiro; Masaoka, Tetsuji; Miki, Takumi; Nakayama, Seiji; Nogawa, Chihiro; Notazawa, Atsuto; Ohmori, Fumito; Sarashina, Isao; Suzuki, Michio; Takagi, Ryousuke; Takahashi, Jun; Takeuchi, Takeshi; Yokoo, Naoki; Satoh, Nori; Toyohara, Haruhiko; Miyashita, Tomoyuki; Wada, Hiroshi; Samata, Tetsuro; Endo, Kazuyoshi; Nagasawa, Hiromichi; Asakawa, Shuichi; Watabe, Shugo

    2013-10-01

    In molluscs, shell matrix proteins are associated with biomineralization, a biologically controlled process that involves nucleation and growth of calcium carbonate crystals. Identification and characterization of shell matrix proteins are important for better understanding of the adaptive radiation of a large variety of molluscs. We searched the draft genome sequence of the pearl oyster Pinctada fucata and annotated 30 different kinds of shell matrix proteins. Of these, we could identified Perlucin, ependymin-related protein and SPARC as common genes shared by bivalves and gastropods; however, most gastropod shell matrix proteins were not found in the P. fucata genome. Glycinerich proteins were conserved in the genus Pinctada. Another important finding with regard to these annotated genes was that numerous shell matrix proteins are encoded by more than one gene; e.g., three ACCBP-like proteins, three CaLPs, five chitin synthase-like proteins, two N16 proteins (pearlins), 10 N19 proteins, two nacreins, four Pifs, nine shematrins, two prismalin-14 proteins, and 21 tyrosinases. This diversity of shell matrix proteins may be implicated in the morphological diversity of mollusc shells. The annotated genes reported here can be searched in P. fucata gene models version 1.1 and genome assembly version 1.0 ( http://marinegenomics.oist.jp/pinctada_fucata ). These genes should provide a useful resource for studies of the genetic basis of biomineralization and evaluation of the role of shell matrix proteins as an evolutionary toolkit among the molluscs.

  7. Weak matrix elements on the lattice - Circa 1995

    SciTech Connect

    Soni, A.

    1995-10-03

    Status of weak matrix elements is reviewed. In particular, e{prime}/e, B {yields} K*{gamma}, B{sub B} and B{sub B}, are discussed and the overall situation with respect to the lattice effort and some of its phenomenological implications are summarised. For e{prime}/e the need for the relevant matrix elements is stressed in view of the forthcoming improved experiments. For some of the operators, (e.g. O{sub 6}), even bound on their matrix elements would be very helpful. On B {yields} K{degrees}{gamma}, a constant behavior of T{sub 2} appears disfavored although dependence of T{sub 2} could, of course, be milder than a simple pole. Improved data is badly needed to settle this important issue firmly, especially in view of its ramification for extractions of V{sub td} from B {yields} {rho}{gamma}. On B{sub {kappa}}, the preliminary result from JLQCD appears to contradict Sharpe et al. JLQCD data seems to fit very well to linear {alpha} dependence and leads to an appreciably lower value of B{sub {kappa}}. Four studies of B{sub {kappa}} in the {open_quotes}full{close_quotes} (n{sub f} = 2) theory indicate very little quenching effects on B{sub {kappa}}; the full theory value seems to be just a little less than the quenched result. Based on expectations from HQET, analysis of B-parameter (B{sub h}{ell}) for the heavy-light mesons via B{sub h}{ell}) = constant + constants{prime}/m{sub h}{ell} is suggested. A summary of an illustrative sample of hadron matrix elements is given and constraints on CKM parameters (e.g. V{sub td}/V{sub ts}, on the unitarity triangle and on x{sub s}/x{sub d}, emerging from the lattice calculations along with experimental results are briefly discussed. In quite a few cases, for the first time, some indication of quenching errors on weak matrix elements are now becoming available.

  8. What Is a Good "g"?

    ERIC Educational Resources Information Center

    Jensen, Arthur R.; Weng, Li-Jen

    1994-01-01

    The stability of psychometric "g," the general factor of intelligence, is investigated in simulated correlation matrices and in typical empirical data from a large battery of mental tests. "G" is robust and almost invariant across methods of analysis. A reasonable strategy for estimating "g" is suggested. (SLD)

  9. Curvature and gravity actions for matrix models

    NASA Astrophysics Data System (ADS)

    Blaschke, Daniel N.; Steinacker, Harold

    2010-08-01

    We show how gravitational actions, in particular the Einstein-Hilbert action, can be obtained from additional terms in Yang-Mills matrix models. This is consistent with recent results on induced gravitational actions in these matrix models, realizing spacetime as four-dimensional brane solutions. It opens up the possibility for a controlled non-perturbative description of gravity through simple matrix models, with interesting perspectives for the problem of vacuum energy. The relation with UV/IR mixing and non-commutative gauge theory is discussed.

  10. Extracellular matrix signaling in morphogenesis and repair.

    PubMed

    Clause, Kelly C; Barker, Thomas H

    2013-10-01

    The extracellular matrix (ECM) is critically important for many cellular processes including growth, differentiation, survival, and morphogenesis. Cells remodel and reshape the ECM by degrading and reassembling it, playing an active role in sculpting their surrounding environment and directing their own phenotypes. Both mechanical and biochemical molecules influence ECM dynamics in multiple ways; by releasing small bioactive signaling molecules, releasing growth factors stored within the ECM, eliciting structural changes to matrix proteins which expose cryptic sites and by degrading matrix proteins directly. The dynamic reciprocal communication between cells and the ECM plays a fundamental roll in tissue development, homeostasis, and wound healing.

  11. Visual Matrix Clustering of Social Networks

    SciTech Connect

    Wong, Pak C.; Mackey, Patrick S.; Foote, Harlan P.; May, Richard A.

    2013-07-01

    The prevailing choices to graphically represent a social network in today’s literature are a node-link graph layout and an adjacency matrix. Both visualization techniques have unique strengths and weaknesses when applied to different domain applications. In this article, we focus our discussion on adjacency matrix and how to turn the matrix-based visualization technique from merely showing pairwise associations among network actors (or graph nodes) to depicting clusters of a social network. We also use node-link layouts to supplement the discussion.

  12. Scattering matrix theory for stochastic scalar fields.

    PubMed

    Korotkova, Olga; Wolf, Emil

    2007-05-01

    We consider scattering of stochastic scalar fields on deterministic as well as on random media, occupying a finite domain. The scattering is characterized by a generalized scattering matrix which transforms the angular correlation function of the incident field into the angular correlation function of the scattered field. Within the accuracy of the first Born approximation this matrix can be expressed in a simple manner in terms of the scattering potential of the scatterer. Apart from determining the angular distribution of the spectral intensity of the scattered field, the scattering matrix makes it possible also to determine the changes in the state of coherence of the field produced on scattering.

  13. A matrix model from string field theory

    NASA Astrophysics Data System (ADS)

    Zeze, Syoji

    2016-09-01

    We demonstrate that a Hermitian matrix model can be derived from level truncated open string field theory with Chan-Paton factors. The Hermitian matrix is coupled with a scalar and U(N) vectors which are responsible for the D-brane at the tachyon vacuum. Effective potential for the scalar is evaluated both for finite and large N. Increase of potential height is observed in both cases. The large N matrix integral is identified with a system of N ZZ branes and a ghost FZZT brane.

  14. Generic construction of efficient matrix product operators

    NASA Astrophysics Data System (ADS)

    Hubig, C.; McCulloch, I. P.; Schollwöck, U.

    2017-01-01

    Matrix product operators (MPOs) are at the heart of the second-generation density matrix renormalization group (DMRG) algorithm formulated in matrix product state language. We first summarize the widely known facts on MPO arithmetic and representations of single-site operators. Second, we introduce three compression methods (rescaled SVD, deparallelization, and delinearization) for MPOs and show that it is possible to construct efficient representations of arbitrary operators using MPO arithmetic and compression. As examples, we construct powers of a short-ranged spin-chain Hamiltonian, a complicated Hamiltonian of a two-dimensional system and, as proof of principle, the long-range four-body Hamiltonian from quantum chemistry.

  15. Embedded systems for controlling LED matrix displays

    NASA Astrophysics Data System (ADS)

    Marghescu, Cristina; Drumea, Andrei

    2016-12-01

    LED matrix displays are a common presence in everyday life - they can be found in trains, buses, tramways, office information tables or outdoor media. The structure of the display unit is similar for all these devices, a matrix of light emitting diodes coupled between row and column lines, but there are many options for the display controller that switches these lines. Present paper analyzes different types of embedded systems that can control the LED matrix, based on single board computers, on microcontrollers with different peripheral devices or with programmable logic devices like field programmable gate arrays with implemented soft processor cores. Scalability, easiness of implementation and costs are analyzed for all proposed solutions.

  16. Learned fusion operators based on matrix completion

    NASA Astrophysics Data System (ADS)

    Risko, Kelly K. D.; Hester, Charles F.

    2011-05-01

    The efficient and timely management of imagery captured in the battlefield requires methods capable of searching the voluminous databases and extracting highly symbolic concepts. When processing images, a semantic and definition gap exists between machine representations and the user's language. Based on matrix completion techniques, we present a fusion operator that fuses imagery and expert knowledge provided by user inputs during post analysis. Specifically, an information matrix is formed from imagery and a class map as labeled by an expert. From this matrix an image operator is derived for the extraction/prediction of information from future imagery. We will present results using this technique on single mode data.

  17. High-temperature polymer matrix composites

    NASA Technical Reports Server (NTRS)

    Meador, Michael A.

    1990-01-01

    Polymers research at the NASA Lewis Research Center has produced high-temperature, easily processable resin systems, such as PMR-15. In addition, the Polymers Branch has investigated ways to improve the mechanical properties of polymers and the microcracking resistance of polymer matrix composites in response to industry need for new and improved aeropropulsion materials. Current and future research in the Polymers Branch is aimed at advancing the upper use temperature of polymer matrix composites to 700 F and beyond by developing new resins, by examining the use of fiber reinforcements other than graphite, and by developing coatings for polymer matrix composites to increase their oxidation resistance.

  18. Bilateral kidney matrix stones: a rare case

    PubMed Central

    Lahyani, Mounir; Rhannam, Yassine; Slaoui, Amine; Touzani, Alae; Karmouni, Tarik; Elkhader, Khalid; Koutani, Abdellatif; Andaloussi, Ahmed Ibn attya

    2016-01-01

    Kedney matrix stones are a rare form of calculi. Flank pain and urinary tract infections (UTI) are the most common presentations of matrix calculi. The diagnosis is usually made at surgery, but some preoperative radiographic findings might be suggestive. Open surgery was the method of choice for treatment. However, combination of ureterorenoscopy and percutaneous nephrolithotomy (PCNL) was found to be safe and effective. We report a rare case of renal and ureteral matrix stones that were diagnosed and treated by open surgery. We also describe its clinical, radiological and therapeutic features through a review of the literature. PMID:28292065

  19. A transilient matrix for moist convection

    SciTech Connect

    Romps, D.; Kuang, Z.

    2011-08-15

    A method is introduced for diagnosing a transilient matrix for moist convection. This transilient matrix quantifies the nonlocal transport of air by convective eddies: for every height z, it gives the distribution of starting heights z{prime} for the eddies that arrive at z. In a cloud-resolving simulation of deep convection, the transilient matrix shows that two-thirds of the subcloud air convecting into the free troposphere originates from within 100 m of the surface. This finding clarifies which initial height to use when calculating convective available potential energy from soundings of the tropical troposphere.

  20. A graphical R-matrix atomic collision environment

    NASA Astrophysics Data System (ADS)

    Busby, David William

    [/cal R]-matrix theory has been used effectively to compute properties characterising atomic and molecular collisions. Large Fortran packages have been developed over the past twenty-five years, which are esoteric and can sometimes be difficult to use. The aim of this research is to design and implement, using modern computer science techniques, an environment which will render the packages more straight forward and accessible. It is postulated that the interactive manipulation of graphical abstractions of the underlying physics will allow the user to concentrate on the physics of the process being studied. This approach renders the new [/cal R]-matrix packages simple to use by novice and experienced users alike, thereby improving their usefulness to the physics community. The Graphical [/cal R]-matrix Atomic Collision Environment (G[/cal R]ACE) is comprised of four graphical user interfaces. Grace expedites the construction and editing of input data stipulated by the [/cal R]-matrix program packages. Data can be entered symbolically and is extensively validated, through a series of graphical windows. The generated text file enables the [/cal R]-matrix package to be executed on a remote supercomputer to which the workstation is networked. Connected to a database of Clementi-type orbitals, pseudo facilitates the computation of pseudo-orbitals, incorporated in grace. The H-file [/cal B]rowser displays a graphical abstraction representing the physics of an inner region [/cal R]-matrix computation. This pin-points limitations which may need to be modified to improve the computation. [/cal A]nalysis provides a graphical environment on the local workstation where results of the remote computation may be displayed and interpreted. Eigenphase sums can be displayed graphically as a function of energy, where resonance fits can be performed. [/cal A]nalysis enables further points to be calculated if there is insufficient data. Effective collisions strengths can also be

  1. Quantitative sandwich ELISA for determination of traces of hazelnut (Corylus avellana) protein in complex food matrixes.

    PubMed

    Holzhauser, T; Vieths, S

    1999-10-01

    A hazelnut-specific sandwich-type ELISA based on polyclonal antisera was developed for detection of hidden hazelnut protein residues in complex food matrixes. In the absence of a food matrix, extractable protein from different native and toasted hazelnuts was detected at rates of 94 +/- 13 and 96 +/- 7% applying standards prepared from native and toasted hazelnuts, respectively. From complex food matrixes, 0.001-10% of hazelnut was recovered between 67 and 132%, in average by 106 +/- 17%. Depending on the food matrix, hazelnut protein could be detected down to the ppb (ng/g) level. Intraassay precision was <6% for hazelnut >/= 0.001% and interassay precision was <15% for hazelnut >/= 0.01%. In 12 of 28 commercial food products without labeling or declaration of hazelnut components, between 2 and 421 ppm of hazelnut protein was detected, demonstrating a remarkable presence of potentially allergenic hazelnut protein "hidden" in commercial food products.

  2. Sensitivity of solar g-modes to varying G cosmologies

    NASA Astrophysics Data System (ADS)

    Guenther, D. B.; Sills, Ken; Demarque, Pierre; Krauss, Lawrence M.

    1995-05-01

    The sensitivity of the solar g-mode oscillation spectrum to variability in the universal gravitational constant G is described. Solar models in varying G cosmologies were constructed by evolving a zero-age main-sequence stellar model to the Sun's current age, while allowing the value of G to change according to the power law G(t) proportional to t-beta, where Beta approximately equals delta G/GH and H is the Hubble constant. All solar models were constrained to the observed luminosity and radius at the current age of the Sun by adjusting the helium abundance and the mixing-length parameter of the models in the usual way for standard stellar models. Low-l g-mode oscillation periods were calculated for each of the models and compared to the claimed observation of the solar g-mode oscillation spectrum by Hill & Gu (1990). If one accepts Hill & Gu's claims, then within the uncertainties of the physics of the solar model calculation, our models rule out all but (delta G/GH) less than approximately 0.05. In other words, we conclude that G could not have varied by more than 2% over the past 4.5 Gyr, the lifetime of the present-day Sun. This result lends independent support to the validity of the standard solar model.

  3. Sensitivity of solar g-modes to varying G cosmologies

    NASA Technical Reports Server (NTRS)

    Guenther, D. B.; Sills, Ken; Demarque, Pierre; Krauss, Lawrence M.

    1995-01-01

    The sensitivity of the solar g-mode oscillation spectrum to variability in the universal gravitational constant G is described. Solar models in varying G cosmologies were constructed by evolving a zero-age main-sequence stellar model to the Sun's current age, while allowing the value of G to change according to the power law G(t) proportional to t(exp -beta), where Beta approximately equals delta G/GH and H is the Hubble constant. All solar models were constrained to the observed luminosity and radius at the current age of the Sun by adjusting the helium abundance and the mixing-length parameter of the models in the usual way for standard stellar models. Low-l g-mode oscillation periods were calculated for each of the models and compared to the claimed observation of the solar g-mode oscillation spectrum by Hill & Gu (1990). If one accepts Hill & Gu's claims, then within the uncertainties of the physics of the solar model calculation, our models rule out all but (delta G/GH) less than approximately 0.05. In other words, we conclude that G could not have varied by more than 2% over the past 4.5 Gyr, the lifetime of the present-day Sun. This result lends independent support to the validity of the standard solar model.

  4. Spin Matrix theory: a quantum mechanical model of the AdS/CFT correspondence

    NASA Astrophysics Data System (ADS)

    Harmark, Troels; Orselli, Marta

    2014-11-01

    We introduce a new quantum mechanical theory called Spin Matrix theory (SMT). The theory is interacting with a single coupling constant g and is based on a Hilbert space of harmonic oscillators with a spin index taking values in a Lie (super)algebra representation as well as matrix indices for the adjoint representation of U( N). We show that SMT describes super-Yang-Mills theory (SYM) near zero-temperature critical points in the grand canonical phase diagram. Equivalently, SMT arises from non-relativistic limits of SYM. Even though SMT is a non-relativistic quantum mechanical theory it contains a variety of phases mimicking the AdS/CFT correspondence. Moreover, the g → ∞ limit of SMT can be mapped to the supersymmetric sector of string theory on AdS5 × S 5. We study SU(2) SMT in detail. At large N and low temperatures it is a theory of spin chains that for small g resembles planar gauge theory and for large g a non-relativistic string theory. When raising the temperature a partial deconfinement transition occurs due to finite- N effects. For sufficiently high temperatures the partially deconfined phase has a classical regime. We find a matrix model description of this regime at any coupling g. Setting g = 0 it is a theory of N 2 + 1 harmonic oscillators while for large g it becomes 2 N harmonic oscillators.

  5. Matrix models of 2d gravity

    SciTech Connect

    Ginsparg, P.

    1991-01-01

    These are introductory lectures for a general audience that give an overview of the subject of matrix models and their application to random surfaces, 2d gravity, and string theory. They are intentionally 1.5 years out of date.

  6. Matrix models of 2d gravity

    SciTech Connect

    Ginsparg, P.

    1991-12-31

    These are introductory lectures for a general audience that give an overview of the subject of matrix models and their application to random surfaces, 2d gravity, and string theory. They are intentionally 1.5 years out of date.

  7. Amyloid Structures as Biofilm Matrix Scaffolds

    PubMed Central

    Taglialegna, Agustina; Lasa, Iñigo

    2016-01-01

    Recent insights into bacterial biofilm matrix structures have induced a paradigm shift toward the recognition of amyloid fibers as common building block structures that confer stability to the exopolysaccharide matrix. Here we describe the functional amyloid systems related to biofilm matrix formation in both Gram-negative and Gram-positive bacteria and recent knowledge regarding the interaction of amyloids with other biofilm matrix components such as extracellular DNA (eDNA) and the host immune system. In addition, we summarize the efforts to identify compounds that target amyloid fibers for therapeutic purposes and recent developments that take advantage of the amyloid structure to engineer amyloid fibers of bacterial biofilm matrices for biotechnological applications. PMID:27185827

  8. Superfund Chemical Data Matrix (SCDM) Query

    EPA Pesticide Factsheets

    This site allows you to to easily query the Superfund Chemical Data Matrix (SCDM) and generate a list of the corresponding Hazard Ranking System (HRS) factor values, benchmarks, and data elements that you need.

  9. Axial grading of inert matrix fuels

    SciTech Connect

    Recktenwald, G. D.; Deinert, M. R.

    2012-07-01

    Burning actinides in an inert matrix fuel to 750 MWd/kg IHM results in a significant reduction in transuranic isotopes. However, achieving this level of burnup in a standard light water reactor would require residence times that are twice that of uranium dioxide fuels. The reactivity of an inert matrix assembly at the end of life is less than 1/3 of its beginning of life reactivity leading to undesirable radial and axial power peaking in the reactor core. Here we show that axial grading of the inert matrix fuel rods can reduce peaking significantly. Monte Carlo simulations are used to model the assembly level power distributions in both ungraded and graded fuel rods. The results show that an axial grading of uranium dioxide and inert matrix fuels with erbium can reduces power peaking by more than 50% in the axial direction. The reduction in power peaking enables the core to operate at significantly higher power. (authors)

  10. Celsian Glass-Ceramic Matrix Composites

    NASA Technical Reports Server (NTRS)

    Bansal, Narottam P.; Dicarlo, James A.

    1996-01-01

    Glass-ceramic matrix reinforced fiber composite materials developed for use in low dielectric applications, such as radomes. Materials strong and tough, exhibit low dielectric properties, and endure high temperatures.

  11. Optimal matrix approximants in structural identification

    NASA Technical Reports Server (NTRS)

    Beattie, C. A.; Smith, S. W.

    1992-01-01

    Problems of model correlation and system identification are central in the design, analysis, and control of large space structures. Of the numerous methods that have been proposed, many are based on finding minimal adjustments to a model matrix sufficient to introduce some desirable quality into that matrix. In this work, several of these methods are reviewed, placed in a modern framework, and linked to other previously known ideas in computational linear algebra and optimization. This new framework provides a point of departure for a number of new methods which are introduced here. Significant among these is a method for stiffness matrix adjustment which preserves the sparsity pattern of an original matrix, requires comparatively modest computational resources, and allows robust handling of noisy modal data. Numerical examples are included to illustrate the methods presented herein.

  12. Chondrule-matrix relationships in chondritic meteorites

    NASA Technical Reports Server (NTRS)

    Brearley, A. J.

    1994-01-01

    The relationship between chondrules and matrix (fine grained material with a grain size less than 5 micrometers) in chondritic meteorites has been the subject of considerable controversy and no consensus currently exists. The coexistence of these two components in meteorites with bulk compositions that deviate only slightly from CI abundances suggests that cosmochemically their origins are closely linked. Any consideration of the relationship between chondrules and matrix hinges to a large degree on the origin of matrix. The entire spectrum of models exists from matrix as a nebular product to derivation entirely from chondrules. Early models of solar nebular evolution viewed chondrites as a two-component mixture of high- and low-temperature condensates. However, this model has been challenged by the recognition that the nebula was probably not uniformly vaporized.

  13. Matrix Gla protein in tumoral pathology.

    PubMed

    Gheorghe, Simona Roxana; Crăciun, Alexandra Mărioara

    2016-01-01

    Matrix Gla protein is a vitamin K-dependent protein secreted by chondrocytes and vascular smooth muscle cells. The presence of matrix Gla protein was reported in arterial and venous walls, lungs, kidney, uterus, heart, tooth cementum and eyes. Several studies identified matrix Gla protein in tumoral pathology. Until recently, it was thought to only have an inhibitory role of physiological and ectopic calcification. New studies demonstrated that it also has a role in physiological and pathological angiogenesis, as well as in tumorigenesis. The aim of this review is to report the latest findings related to the expression and clinical implications of matrix Gla protein in different types of cancer with an emphasis on cerebral tumors.

  14. Comix, a New Matrix Element Generator

    SciTech Connect

    Gleisberg, Tanju; Hoche, Stefan; /Durham U., IPPP

    2008-09-03

    We present a new tree-level matrix element generator, based on the color dressed Berends-Giele recursive relations. We discuss two new algorithms for phase space integration, dedicated to be used with large multiplicities and color sampling.

  15. Microstructure of Matrix in UHTC Composites

    NASA Technical Reports Server (NTRS)

    Johnson, Sylvia; Stackpoole, Margaret; Gusman, Michael I.; Chavez-Garia Jose; Doxtad, Evan

    2011-01-01

    Approaches to controlling the microstructure of Ultra High Temperature Ceramics (UHTCs) are described.. One matrix material has been infiltrated into carbon weaves to make composite materials. The microstructure of these composites is described.

  16. Nuclear waste storage container with metal matrix

    DOEpatents

    Sump, Kenneth R.

    1978-01-01

    The invention relates to a storage container for high-level waste having a metal matrix for the high-level waste, thereby providing greater impact strength for the waste container and increasing heat transfer properties.

  17. Superfund Chemical Data Matrix (SCDM) Query - Popup

    EPA Pesticide Factsheets

    This site allows you to to easily query the Superfund Chemical Data Matrix (SCDM) and generate a list of the corresponding Hazardous Ranking System (HRS) factor values, benchmarks, and data elements that you need.

  18. Osteoblast fibronectin mRNA, protein synthesis, and matrix are unchanged after exposure to microgravity

    NASA Technical Reports Server (NTRS)

    Hughes-Fulford, M.; Gilbertson, V.

    1999-01-01

    The well-defined osteoblast line, MC3T3-E1 was used to examine fibronectin (FN) mRNA levels, protein synthesis, and extracellular FN matrix accumulation after growth activation in spaceflight. These osteoblasts produce FN extracellular matrix (ECM) known to regulate adhesion, differentiation, and function in adherent cells. Changes in bone ECM and osteoblast cell shape occur in spaceflight. To determine whether altered FN matrix is a factor in causing these changes in spaceflight, quiescent osteoblasts were launched into microgravity and were then sera activated with and without a 1-gravity field. Synthesis of FN mRNA, protein, and matrix were measured after activation in microgravity. FN mRNA synthesis is significantly reduced in microgravity (0-G) when compared to ground (GR) osteoblasts flown in a centrifuge simulating earth's gravity (1-G) field 2.5 h after activation. However, 27.5 h after activation there were no significant differences in mRNA synthesis. A small but significant reduction of FN protein was found in the 0-G samples 2.5 h after activation. Total FN protein 27.5 h after activation showed no significant difference between any of the gravity conditions, however, there was a fourfold increase in absolute amount of protein synthesized during the incubation. Using immunofluorescence, we found no significant differences in the amount or in the orientation of the FN matrix after 27.5 h in microgravity. These results demonstrate that FN is made by sera-activated osteoblasts even during exposure to microgravity. These data also suggest that after a total period of 43 h of spaceflight FN transcription, translation, or altered matrix assembly is not responsible for the altered cell shape or altered matrix formation of osteoblasts.

  19. Genetic dissection of peroxisome-associated matrix protein degradation in Arabidopsis thaliana.

    PubMed

    Burkhart, Sarah E; Lingard, Matthew J; Bartel, Bonnie

    2013-01-01

    Peroxisomes are organelles that sequester certain metabolic pathways; many of these pathways generate H(2)O(2), which can damage proteins. However, little is known about how damaged or obsolete peroxisomal proteins are degraded. We exploit developmentally timed peroxisomal content remodeling in Arabidopsis thaliana to elucidate peroxisome-associated protein degradation. Isocitrate lyase (ICL) is a peroxisomal glyoxylate cycle enzyme necessary for early seedling development. A few days after germination, photosynthesis begins and ICL is degraded. We previously found that ICL is stabilized when a peroxisome-associated ubiquitin-conjugating enzyme and its membrane anchor are both mutated, suggesting that matrix proteins might exit the peroxisome for ubiquitin-dependent cytosolic degradation. To identify additional components needed for peroxisome-associated matrix protein degradation, we mutagenized a line expressing GFP-ICL, which is degraded similarly to endogenous ICL, and identified persistent GFP-ICL fluorescence (pfl) mutants. We found three pfl mutants that were defective in PEROXIN14 (PEX14/At5g62810), which encodes a peroxisomal membrane protein that assists in importing proteins into the peroxisome matrix, indicating that proteins must enter the peroxisome for efficient degradation. One pfl mutant was missing the peroxisomal 3-ketoacyl-CoA thiolase encoded by the PEROXISOME DEFECTIVE1 (PED1/At2g33150) gene, suggesting that peroxisomal metabolism influences the rate of matrix protein degradation. Finally, one pfl mutant that displayed normal matrix protein import carried a novel lesion in PEROXIN6 (PEX6/At1g03000), which encodes a peroxisome-tethered ATPase that is involved in recycling matrix protein receptors back to the cytosol. The isolation of pex6-2 as a pfl mutant supports the hypothesis that matrix proteins can exit the peroxisome for cytosolic degradation.

  20. Shrinkage approach for EEG covariance matrix estimation.

    PubMed

    Beltrachini, Leandro; von Ellenrieder, Nicolas; Muravchik, Carlos H

    2010-01-01

    We present a shrinkage estimator for the EEG spatial covariance matrix of the background activity. We show that such an estimator has some advantages over the maximum likelihood and sample covariance estimators when the number of available data to carry out the estimation is low. We find sufficient conditions for the consistency of the shrinkage estimators and results concerning their numerical stability. We compare several shrinkage schemes and show how to improve the estimator by incorporating known structure of the covariance matrix.

  1. Semiclassical matrix elements from periodic orbits

    NASA Technical Reports Server (NTRS)

    Eckhardt, B.; Fishman, S.; Mueller, K.; Wintgen, D.

    1992-01-01

    An extension of Gutzwiller's (1967, 1969, 1970, 1971, 1990) semiclassical theory for chaotic systems that allows a determination of matrix elements in terms of classical periodic orbits. Associated zeta functions are derived. The semiclassical predictions are found to be in good agreement with Fourier transforms of quantum spectra of hydrogen in a magnetic field. Expressions for off-diagonal matrix elements are derived that are extensions of the Bohr correspondence relations for integrable systems.

  2. Semisupervised kernel matrix learning by kernel propagation.

    PubMed

    Hu, Enliang; Chen, Songcan; Zhang, Daoqiang; Yin, Xuesong

    2010-11-01

    The goal of semisupervised kernel matrix learning (SS-KML) is to learn a kernel matrix on all the given samples on which just a little supervised information, such as class label or pairwise constraint, is provided. Despite extensive research, the performance of SS-KML still leaves some space for improvement in terms of effectiveness and efficiency. For example, a recent pairwise constraints propagation (PCP) algorithm has formulated SS-KML into a semidefinite programming (SDP) problem, but its computation is very expensive, which undoubtedly restricts PCPs scalability in practice. In this paper, a novel algorithm, called kernel propagation (KP), is proposed to improve the comprehensive performance in SS-KML. The main idea of KP is first to learn a small-sized sub-kernel matrix (named seed-kernel matrix) and then propagate it into a larger-sized full-kernel matrix. Specifically, the implementation of KP consists of three stages: 1) separate the supervised sample (sub)set X(l) from the full sample set X; 2) learn a seed-kernel matrix on X(l) through solving a small-scale SDP problem; and 3) propagate the learnt seed-kernel matrix into a full-kernel matrix on X . Furthermore, following the idea in KP, we naturally develop two conveniently realizable out-of-sample extensions for KML: one is batch-style extension, and the other is online-style extension. The experiments demonstrate that KP is encouraging in both effectiveness and efficiency compared with three state-of-the-art algorithms and its related out-of-sample extensions are promising too.

  3. Polymer Matrix Composite Material Oxygen Compatibility

    NASA Technical Reports Server (NTRS)

    Owens, Tom

    2001-01-01

    Carbon fiber/polymer matrix composite materials look promising as a material to construct liquid oxygen (LOX) tanks. Based on mechanical impact tests the risk will be greater than aluminum, however, the risk can probably be managed to an acceptable level. Proper tank design and operation can minimize risk. A risk assessment (hazard analysis) will be used to determine the overall acceptability for using polymer matrix composite materials.

  4. Mechanisms balancing skeletal matrix synthesis and degradation.

    PubMed Central

    Blair, Harry C; Zaidi, Mone; Schlesinger, Paul H

    2002-01-01

    Bone is regulated by evolutionarily conserved signals that balance continuous differentiation of bone matrix-producing cells against apoptosis and matrix removal. This is continued from embryogenesis, where the skeleton differentiates as a solid mass and is shaped into separate bones by cell death and proteolysis. The two major tissues of the skeleton are avascular cartilage, with an extracellular matrix based on type II collagen and hydrophilic proteoglycans, and bone, a stronger and lighter material based on oriented type I collagen and hydroxyapatite. Both differentiate from the same mesenchymal stem cells. This differentiation is regulated by a family of related signals centred on bone morphogenic proteins. Fibroblast growth factors, Indian hedgehog and parathyroid hormone-related protein are important in determining the type of matrix and the relation of skeletal and non-skeletal structures. Removal of mineralized matrix involves apoptosis of matrix cells and differentiation of acid-secreting cells (osteoclasts) from macrophage precursors. Key regulators of matrix removal are signals in the tumour-necrosis-factor family. Osteoclasts dissolve bone by isolating a region of the matrix and secreting HCl and proteinases at that site. Successive cycles of removal and replacement allow growth, repair and remodelling. The signals for bone turnover are predominantly cell-membrane-associated, allowing very specific spatial regulation. In addition to its support function, bone is a reservoir of Ca2+, PO3-(4) and OH-. Secondary modulation of mineral secretion and bone degradation are mediated by humoral signals, including parathyroid hormone and vitamin D, as well as the cytokines that also regulate the underlying cell differentiation. PMID:12023876

  5. Micromechanical Modeling of Woven Metal Matrix Composites

    NASA Technical Reports Server (NTRS)

    Bednarcyk, Brett A.; Pindera, Marek-Jerzy

    1997-01-01

    This report presents the results of an extensive micromechanical modeling effort for woven metal matrix composites. The model is employed to predict the mechanical response of 8-harness (8H) satin weave carbon/copper (C/Cu) composites. Experimental mechanical results for this novel high thermal conductivity material were recently reported by Bednarcyk et al. along with preliminary model results. The micromechanics model developed herein is based on an embedded approach. A micromechanics model for the local (micro-scale) behavior of the woven composite, the original method of cells (Aboudi), is embedded in a global (macro-scale) micromechanics model (the three-dimensional generalized method of cells (GMC-3D) (Aboudi). This approach allows representation of true repeating unit cells for woven metal matrix composites via GMC-3D, and representation of local effects, such as matrix plasticity, yarn porosity, and imperfect fiber-matrix bonding. In addition, the equations of GMC-3D were reformulated to significantly reduce the number of unknown quantities that characterize the deformation fields at the microlevel in order to make possible the analysis of actual microstructures of woven composites. The resulting micromechanical model (WCGMC) provides an intermediate level of geometric representation, versatility, and computational efficiency with respect to previous analytical and numerical models for woven composites, but surpasses all previous modeling work by allowing the mechanical response of a woven metal matrix composite, with an elastoplastic matrix, to be examined for the first time. WCGMC is employed to examine the effects of composite microstructure, porosity, residual stresses, and imperfect fiber-matrix bonding on the predicted mechanical response of 8H satin C/Cu. The previously reported experimental results are summarized, and the model predictions are compared to monotonic and cyclic tensile and shear test data. By considering appropriate levels of porosity

  6. Application of Fuzzy Logic to Matrix FMECA

    NASA Astrophysics Data System (ADS)

    Shankar, N. Ravi; Prabhu, B. S.

    2001-04-01

    A methodology combining the benefits of Fuzzy Logic and Matrix FMEA is presented in this paper. The presented methodology extends the risk prioritization beyond the conventional Risk Priority Number (RPN) method. Fuzzy logic is used to calculate the criticality rank. Also the matrix approach is improved further to develop a pictorial representation retaining all relevant qualitative and quantitative information of several FMEA elements relationships. The methodology presented is demonstrated by application to an illustrative example.

  7. Random Matrix Analysis of Human EEG Data

    NASA Astrophysics Data System (ADS)

    Šeba, P.

    2003-11-01

    We use random matrix theory to demonstrate the existence of generic and subject-independent features of the ensemble of correlation matrices extracted from human EEG data. In particular, the spectral density as well as the level spacings was analyzed and shown to be generic and subject independent. We also investigate number variance distributions. In this case we show that when the measured subject is visually stimulated the number variance displays deviations from the random matrix prediction.

  8. Fibre-Matrix Interaction in Soft Tissue

    SciTech Connect

    Guo, Zaoyang

    2010-05-21

    Although the mechanical behaviour of soft tissue has been extensively studied, the interaction between the collagen fibres and the ground matrix has not been well understood and is therefore ignored by most constitutive models of soft tissue. In this paper, the human annulus fibrosus is used as an example and the potential fibre-matrix interaction is identified by careful investigation of the experimental results of biaxial and uniaxial testing of the human annulus fibrosus. First, the uniaxial testing result of the HAF along the axial direction is analysed and it is shown that the mechanical behaviour of the ground matrix can be well simulated by the incompressible neo-Hookean model when the collagen fibres are all under contraction. If the collagen fibres are stretched, the response of the ground matrix can still be described by the incompressible neo-Hookean model, but the effective stiffness of the matrix depends on the fibre stretch ratio. This stiffness can be more than 10 times larger than the one obtained with collagen fibres under contraction. This phenomenon can only be explained by the fibre-matrix interaction. Furthermore, we find that the physical interpretation of this interaction includes the inhomogeneity of the soft tissue and the fibre orientation dispersion. The dependence of the tangent stiffness of the matrix on the first invariant of the deformation tensor can also be explained by the fibre orientation dispersion. The significant effect of the fibre-matrix interaction strain energy on mechanical behaviour of the soft tissue is also illustrated by comparing some simulation results.

  9. Nanophosphor composite scintillator with a liquid matrix

    DOEpatents

    McKigney, Edward Allen; Burrell, Anthony Keiran; Bennett, Bryan L.; Cooke, David Wayne; Ott, Kevin Curtis; Bacrania, Minesh Kantilal; Del Sesto, Rico Emilio; Gilbertson, Robert David; Muenchausen, Ross Edward; McCleskey, Thomas Mark

    2010-03-16

    An improved nanophosphor scintillator liquid comprises nanophosphor particles in a liquid matrix. The nanophosphor particles are optionally surface modified with an organic ligand. The surface modified nanophosphor particle is essentially surface charge neutral, thereby preventing agglomeration of the nanophosphor particles during dispersion in a liquid scintillator matrix. The improved nanophosphor scintillator liquid may be used in any conventional liquid scintillator application, including in a radiation detector.

  10. Fuel cell with electrolyte matrix assembly

    DOEpatents

    Kaufman, Arthur; Pudick, Sheldon; Wang, Chiu L.

    1988-01-01

    This invention is directed to a fuel cell employing a substantially immobilized electrolyte imbedded therein and having a laminated matrix assembly disposed between the electrodes of the cell for holding and distributing the electrolyte. The matrix assembly comprises a non-conducting fibrous material such as silicon carbide whiskers having a relatively large void-fraction and a layer of material having a relatively small void-fraction.

  11. Molten carbonate fuel cell matrix tape

    SciTech Connect

    Vine, R.W.; Schroll, C.R.; Reiser, C.A.

    1986-04-08

    A matrix material for a molten carbonate fuel cell is described comprising particles inert to molten carbonate electrolyte having a particle size less than about 1 micron, ceramic particles having a particle size greater than about 25 microns, and an organic polymeric binder material, the binder material being present in an amount at least about 35% by volume, the matrix material being flexible, pliable, and compliant at room temperature.

  12. Cryogenic regenerator including sarancarbon heat conduction matrix

    NASA Technical Reports Server (NTRS)

    Jones, Jack A. (Inventor); Petrick, S. Walter (Inventor); Britcliffe, Michael J. (Inventor)

    1989-01-01

    A saran carbon matrix is employed to conduct heat through the heat storing volume of a cryogenic regenerator. When helium is adsorbed into the saran carbon matrix, the combination exhibits a volumetric specific heat much higher than previously used lead balls. A helium adsorbed saran regenerator should allow much lower refrigerator temperatures than those practically obtainable with lead based regenerators for regenerator type refrigeration systems.

  13. Investigations into ultraviolet matrix-assisted laser desorption

    SciTech Connect

    Heise, T.W.

    1993-07-01

    Matrix-assisted laser desorption (MALD) is a technique for converting large biomolecules into gas phase ions. Some characteristics of the commonly used uv matrices are determined. Solubilities in methanol range from 0.1 to 0.5 M. Solid phase absorption spectra are found to be similar to solution, but slightly red-shifted. Acoustic and quartz crystal microbalance signals are investigated as possible means of uv-MALD quantitation. Evidence for the existence of desorption thresholds is presented. Threshold values are determined to be in the range of 2 to 3 MW/cm{sup 2}. A transient imaging technique based on laser-excited fluorescence for monitoring MALD plumes is described. Sensitivity is well within the levels required for studying matrix-assisted laser desorption, where analyte concentrations are significantly lower than those in conventional laser desorption. Results showing the effect of film morphology, particularly film thickness, on plume dynamics are presented. In particular, MALD plumes from thicker films tend to exhibit higher axial velocities. Fluorescent labeling of protein and of DNA is used to allow imaging of their uv-MALD generated plumes. Integrated concentrations are available with respect to time, making it possible to assess the rate of fragmentation. The spatial and temporal distributions are important for the design of secondary ionization schemes to enhance ion yields and for the optimization of ion collection in time-of-flight MS instruments to maximize resolution. Such information could also provide insight into whether ionization is closely associated with the desorption step or whether it is a result of subsequent collisions with the matrix gas (e.g., proton transfer). Although the present study involves plumes in a normal atmosphere, adaptation to measurements in vacuum (e.g., inside a mass spectrometer) should be straightforward.

  14. Sterile Neutrinos in a 6x6 Matrix

    NASA Astrophysics Data System (ADS)

    Goldman, T.; McKellar, B. H. J.; Stephenson, G. J., Jr.

    2006-10-01

    An early study of neutrino mixing within the see-saw framework considered random mass matrices in what is now known as the sterile sector[1]. The mixing angles in the lepton sector were found to be closely distributed about the CKM angles that were assumed. In that work, rank 3 was assumed for the weak isospin zero Majorana mass matrix in the sterile neutrino sector. We report here on the character of new results using a reduced rank (``singular'') sterile matrix. We find that an additional flavor misalignment in the sterile sector can produce several interesting effects, including: 1) mass eigenstates that lead to very large flavor mixing among active neutrinos, and 2) small values for the 1-3 mixing angle parameter[2]. We also discuss the limits that current observations place on the mass scale of light sterile neutrinos in this model. [1]T. Goldman and G. J. Stephenson, Jr., ``How Large Are the Neutrino Mixing Angles?'' Phys. Rev. D 24, 236 (1981). [2]G. J. Stephenson, Jr. , T. Goldman, B. H. J. McKellar and M. Garbutt, ``Large Mixing from Small: Pseudo-Dirac Neutrinos and the Singular Seesaw,'' Int. J.Mod.Phys.A20 (2005) 6373; [hep-ph/0404015].

  15. Pseudomonas biofilm matrix composition and niche biology

    PubMed Central

    Mann, Ethan E.; Wozniak, Daniel J.

    2014-01-01

    Biofilms are a predominant form of growth for bacteria in the environment and in the clinic. Critical for biofilm development are adherence, proliferation, and dispersion phases. Each of these stages includes reinforcement by, or modulation of, the extracellular matrix. Pseudomonas aeruginosa has been a model organism for the study of biofilm formation. Additionally, other Pseudomonas species utilize biofilm formation during plant colonization and environmental persistence. Pseudomonads produce several biofilm matrix molecules, including polysaccharides, nucleic acids, and proteins. Accessory matrix components shown to aid biofilm formation and adaptability under varying conditions are also produced by pseudomonads. Adaptation facilitated by biofilm formation allows for selection of genetic variants with unique and distinguishable colony morphology. Examples include rugose small-colony variants and wrinkly spreaders (WS), which over produce Psl/Pel or cellulose, respectively, and mucoid bacteria that over produce alginate. The well-documented emergence of these variants suggests that pseudomonads take advantage of matrix-building subpopulations conferring specific benefits for the entire population. This review will focus on various polysaccharides as well as additional Pseudomonas biofilm matrix components. Discussions will center on structure–function relationships, regulation, and the role of individual matrix molecules in niche biology. PMID:22212072

  16. Sparse estimation of a covariance matrix.

    PubMed

    Bien, Jacob; Tibshirani, Robert J

    2011-12-01

    We suggest a method for estimating a covariance matrix on the basis of a sample of vectors drawn from a multivariate normal distribution. In particular, we penalize the likelihood with a lasso penalty on the entries of the covariance matrix. This penalty plays two important roles: it reduces the effective number of parameters, which is important even when the dimension of the vectors is smaller than the sample size since the number of parameters grows quadratically in the number of variables, and it produces an estimate which is sparse. In contrast to sparse inverse covariance estimation, our method's close relative, the sparsity attained here is in the covariance matrix itself rather than in the inverse matrix. Zeros in the covariance matrix correspond to marginal independencies; thus, our method performs model selection while providing a positive definite estimate of the covariance. The proposed penalized maximum likelihood problem is not convex, so we use a majorize-minimize approach in which we iteratively solve convex approximations to the original nonconvex problem. We discuss tuning parameter selection and demonstrate on a flow-cytometry dataset how our method produces an interpretable graphical display of the relationship between variables. We perform simulations that suggest that simple elementwise thresholding of the empirical covariance matrix is competitive with our method for identifying the sparsity structure. Additionally, we show how our method can be used to solve a previously studied special case in which a desired sparsity pattern is prespecified.

  17. On the Instanton R-matrix

    NASA Astrophysics Data System (ADS)

    Smirnov, Andrey

    2016-08-01

    A torus action on a symplectic variety allows one to construct solutions to the quantum Yang-Baxter equations ( R-matrices). For a torus action on cotangent bundles over flag varieties the resulting R-matrices are the standard rational solutions of the Yang-Baxter equation, well known in the theory of quantum integrable systems. The torus action on the instanton moduli space leads to more complicated R-matrices, depending additionally on two equivariant parameters t 1 and t 2. In this paper we derive an explicit expression for the R-matrix associated with the instanton moduli space. We study its matrix elements and its Taylor expansion in the powers of the spectral parameter. Certain matrix elements of this R-matrix give a generating function for the characteristic classes of tautological bundles over the Hilbert schemes in terms of the bosonic cut-and-join operators. In particular we rederive from the R-matrix the well known Lehn's formula for the first Chern class. We explicitly compute the first several coefficients for the power series expansion of the R-matrix in the spectral parameter. These coefficients are represented by simple contour integrals of some symmetrized bosonic fields.

  18. Temperature dependent nonlinear metal matrix laminae behavior

    NASA Technical Reports Server (NTRS)

    Barrett, D. J.; Buesking, K. W.

    1986-01-01

    An analytical method is described for computing the nonlinear thermal and mechanical response of laminated plates. The material model focuses upon the behavior of metal matrix materials by relating the nonlinear composite response to plasticity effects in the matrix. The foundation of the analysis is the unidirectional material model which is used to compute the instantaneous properties of the lamina based upon the properties of the fibers and matrix. The unidirectional model assumes that the fibers properties are constant with temperature and assumes that the matrix can be modelled as a temperature dependent, bilinear, kinematically hardening material. An incremental approach is used to compute average stresses in the fibers and matrix caused by arbitrary mechanical and thermal loads. The layer model is incorporated in an incremental laminated plate theory to compute the nonlinear response of laminated metal matrix composites of general orientation and stacking sequence. The report includes comparisons of the method with other analytical approaches and compares theoretical calculations with measured experimental material behavior. A section is included which describes the limitations of the material model.

  19. Genetic Relationships Between Chondrules, Rims and Matrix

    NASA Technical Reports Server (NTRS)

    Huss, G. R.; Alexander, C. M. OD.; Palme, H.; Bland, P. A.; Wasson, J. T.

    2004-01-01

    The most primitive chondrites are composed of chondrules and chondrule fragments, various types of inclusions, discrete mineral grains, metal, sulfides, and fine-grained materials that occur as interchondrule matrix and as chondrule/inclusion rims. Understanding how these components are related is essential for understanding how chondrites and their constituents formed and were processed in the solar nebula. For example, were the first generations of chondrules formed by melting of matrix or matrix precursors? Did chondrule formation result in appreciable transfer of chondrule material into the matrix? Here, we consider three types of data: 1) compositional data for bulk chondrites and matrix, 2) mineralogical and textural information, and 3) the abundances and characteristics of presolar materials that reside in the matrix and rims. We use these data to evaluate the roles of evaporation and condensation, chondrule formation, mixing of different nebular components, and secondary processing both in the nebula and on the parent bodies. Our goal is to identify the things that are reasonably well established and to point out the areas that need additional work.

  20. Detection of dimethylarginines in protein hydrolysates by matrix-assisted laser desorption/ionization mass spectrometry.

    PubMed

    Hsieh, Cheng-Hsilin; Tam, Ming F

    2006-03-01

    We report a method to detect the presence of dimethylarginines on proteins. Peptides with dimethylarginines were hydrolyzed in acid. The hydrolysates were subjected to matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometric analysis using a mixture of alpha-cyano-4-hydroxycinnamic acid and nitrocellulose as matrix. Both asymmetric omega-N(G),N(G)-dimethylarginine and symmetric omega-N(G),N(G')-dimethylarginine give a clear signal at m/z 203. Recombinant Sbp1p modified by Hmt1p in vivo were isolated by affinity chromatography followed by electrophoresis on a polyacrylamide gel and subjected to acid hydrolysis. MALDI-TOF analysis of the acid hydrolysates confirmed the presence of dimethylarginines. The detection limit of the method is estimated at approximately 1pmol of protein.

  1. Modeling the formation of cell-matrix adhesions on a single 3D matrix fiber.

    PubMed

    Escribano, J; Sánchez, M T; García-Aznar, J M

    2015-11-07

    Cell-matrix adhesions are crucial in different biological processes like tissue morphogenesis, cell motility, and extracellular matrix remodeling. These interactions that link cell cytoskeleton and matrix fibers are built through protein clutches, generally known as adhesion complexes. The adhesion formation process has been deeply studied in two-dimensional (2D) cases; however, the knowledge is limited for three-dimensional (3D) cases. In this work, we simulate different local extracellular matrix properties in order to unravel the fundamental mechanisms that regulate the formation of cell-matrix adhesions in 3D. We aim to study the mechanical interaction of these biological structures through a three dimensional discrete approach, reproducing the transmission pattern force between the cytoskeleton and a single extracellular matrix fiber. This numerical model provides a discrete analysis of the proteins involved including spatial distribution, interaction between them, and study of the different phenomena, such as protein clutches unbinding or protein unfolding.

  2. Optical matrix-matrix multiplication method demonstrated by the use of a multifocus hololens.

    PubMed

    Liang, Y Z; Liu, H K

    1984-08-01

    A method of optical matrix-matrix multiplication is presented. The feasibility of the method is also experimentally demonstrated by the use of a dichromated-gelatin multifocus holographic lens (hololens). With the specific values of matrices chosen, the average percentage error between the theoretical and experimental data of the elements of the output matrix of the multiplication of some specific pairs of 3 x 3 matrices is 0.4%, which corresponds to an 8-bit accuracy.

  3. Optical matrix-matrix multiplication method demonstrated by the use of a multifocus hololens

    NASA Technical Reports Server (NTRS)

    Liu, H. K.; Liang, Y.-Z.

    1984-01-01

    A method of optical matrix-matrix multiplication is presented. The feasibility of the method is also experimentally demonstrated by the use of a dichromated-gelatin multifocus holographic lens (hololens). With the specific values of matrices chosen, the average percentage error between the theoretical and experimental data of the elements of the output matrix of the multiplication of some specific pairs of 3 x 3 matrices is 0.4 percent, which corresponds to an 8-bit accuracy.

  4. EA 18G Growler Aircraft (EA 18G)

    DTIC Science & Technology

    2015-12-01

    Selected Acquisition Report (SAR) RCS: DD-A&T(Q&A)823-378 EA-18G Growler Aircraft (EA-18G) As of FY 2017 President’s Budget Defense Acquisition...RDT&E - Research, Development, Test, and Evaluation SAR - Selected Acquisition Report SCP - Service Cost Position TBD - To Be Determined TY - Then Year

  5. Penicillin G Benzathine and Penicillin G Procaine Injection

    MedlinePlus

    ... if you have or have ever had asthma, allergies, hay fever, hives, or kidney disease.tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while receiving penicillin G benzathine and penicillin G procaine injection, call ...

  6. G0/G1 Switch Gene 2 Regulates Cardiac Lipolysis*

    PubMed Central

    Heier, Christoph; Radner, Franz P. W.; Moustafa, Tarek; Schreiber, Renate; Grond, Susanne; Eichmann, Thomas O.; Schweiger, Martina; Schmidt, Albrecht; Cerk, Ines K.; Oberer, Monika; Theussl, H.-Christian; Wojciechowski, Jacek; Penninger, Josef M.; Zimmermann, Robert; Zechner, Rudolf

    2015-01-01

    The anabolism and catabolism of myocardial triacylglycerol (TAG) stores are important processes for normal cardiac function. TAG synthesis detoxifies and stockpiles fatty acids to prevent lipotoxicity, whereas TAG hydrolysis (lipolysis) remobilizes fatty acids from endogenous storage pools as energy substrates, signaling molecules, or precursors for complex lipids. This study focused on the role of G0/G1 switch 2 (G0S2) protein, which was previously shown to inhibit the principal TAG hydrolase adipose triglyceride lipase (ATGL), in the regulation of cardiac lipolysis. Using wild-type and mutant mice, we show the following: (i) G0S2 is expressed in the heart and regulated by the nutritional status with highest expression levels after re-feeding. (ii) Cardiac-specific overexpression of G0S2 inhibits cardiac lipolysis by direct protein-protein interaction with ATGL. This leads to severe cardiac steatosis. The steatotic hearts caused by G0S2 overexpression are less prone to fibrotic remodeling or cardiac dysfunction than hearts with a lipolytic defect due to ATGL deficiency. (iii) Conversely to the phenotype of transgenic mice, G0S2 deficiency results in a de-repression of cardiac lipolysis and decreased cardiac TAG content. We conclude that G0S2 acts as a potent ATGL inhibitor in the heart modulating cardiac substrate utilization by regulating cardiac lipolysis. PMID:26350455

  7. Odd and even sums of generalized Fibonacci numbers by matrix methods

    NASA Astrophysics Data System (ADS)

    Ho, C. K.; Chong, Chin-Yoon

    2014-06-01

    For integers A and B, and positive integers n, we define two generalized Fibonacci sequence {gn} and {hn}, respectively, by the recurrence relations gn+1 = Agn+gn-1 and hn+1 = hn+Bhn-1 where g0 = h0 = 0, g1 = h1 = 1. Using a matrix approach, we obtained the odd sum and even sum of the two sequences for all values of A and B.

  8. Transmission Electron Microscopy of the Matrix Minerals in the Tagish Lake Carbonaceous Chondrite

    NASA Technical Reports Server (NTRS)

    Mikouchi, T.; Kasama, T.; Zolensky, M. E.; Tachikawa, O.

    2001-01-01

    We studied the Tagish Lake matrix minerals by TEM. The result shows similarities to CIs (and CRs) and differences from CMs, but its heterogeneity (e.g., carbonate abundance, saponite/serpentine ratio) suggests its complex history. Additional information is contained in the original extended abstract.

  9. A Transfer Learning Approach for Applying Matrix Factorization to Small ITS Datasets

    ERIC Educational Resources Information Center

    Voß, Lydia; Schatten, Carlotta; Mazziotti, Claudia; Schmidt-Thieme, Lars

    2015-01-01

    Machine Learning methods for Performance Prediction in Intelligent Tutoring Systems (ITS) have proven their efficacy; specific methods, e.g. Matrix Factorization (MF), however suffer from the lack of available information about new tasks or new students. In this paper we show how this problem could be solved by applying Transfer Learning (TL),…

  10. EPA Positive Matrix Factorization (PMF) 5.0 Fundamentals and User Guide

    EPA Science Inventory

    PMF is a multivariate factor analysis tool that decomposes a matrix of speciated sample data into two matrices: factor contributions (G) and factor profiles (F). These factor profiles need to be interpreted by the user to identify the source types that may be contributing to the ...

  11. Method of producing a hybrid matrix fiber composite

    DOEpatents

    Deteresa, Steven J.; Lyon, Richard E.; Groves, Scott E.

    2006-03-28

    Hybrid matrix fiber composites having enhanced compressive performance as well as enhanced stiffness, toughness and durability suitable for compression-critical applications. The methods for producing the fiber composites using matrix hybridization. The hybrid matrix fiber composites comprised of two chemically or physically bonded matrix materials, whereas the first matrix materials are used to impregnate multi-filament fibers formed into ribbons and the second matrix material is placed around and between the fiber ribbons that are impregnated with the first matrix material and both matrix materials are cured and solidified.

  12. Modeling for Matrix Multicracking Evolution of Cross-ply Ceramic-Matrix Composites Using Energy Balance Approach

    NASA Astrophysics Data System (ADS)

    Longbiao, Li

    2015-12-01

    The matrix multicracking evolution of cross-ply ceramic-matrix composites (CMCs) has been investigated using energy balance approach. The multicracking of cross-ply CMCs was classified into five modes, i.e., (1) mode 1: transverse multicracking; (2) mode 2: transverse multicracking and matrix multicracking with perfect fiber/matrix interface bonding; (3) mode 3: transverse multicracking and matrix multicracking with fiber/matrix interface debonding; (4) mode 4: matrix multicracking with perfect fiber/matrix interface bonding; and (5) mode 5: matrix multicracking with fiber/matrix interface debonding. The stress distributions of four cracking modes, i.e., mode 1, mode 2, mode 3 and mode 5, are analysed using shear-lag model. The matrix multicracking evolution of mode 1, mode 2, mode 3 and mode 5, has been determined using energy balance approach. The effects of ply thickness and fiber volume fraction on matrix multicracking evolution of cross-ply CMCs have been investigated.

  13. INTEGRATED COI S200 - Hi-NiCalon FIBER WITH AN S200 MATRIX (POLYMER MATRIX COMPOSITE - PMC) / AETB 1

    NASA Technical Reports Server (NTRS)

    2003-01-01

    INTEGRATED COI S200 - Hi-NiCalon FIBER WITH AN S200 MATRIX (POLYMER MATRIX COMPOSITE - PMC) / AETB 16 (FOAM CORE) / CARBON REINFORCED CYANOESTER (CERAMIC MATRIX COMPOSITE - CMC) HOT STRUCTURE, PANEL 884-1: SAMPLE 1

  14. INTEGRATED COI S200 - Hi-NiCalon FIBER WITH AN S200 MATRIX (POLYMER MATRIX COMPOSITE - PMC) / AETB 1

    NASA Technical Reports Server (NTRS)

    2003-01-01

    INTEGRATED COI S200 - Hi-NiCalon FIBER WITH AN S200 MATRIX (POLYMER MATRIX COMPOSITE - PMC) / AETB 16 (FOAM CORE) / CARBON REINFORCED CYANOESTER (CERAMIC MATRIX COMPOSITE - CMC) HOT STRUCTURE, PANEL 884-1: SAMPLE 3

  15. Conformations of propargyl alcohol and its interaction with acetylene: A matrix isolation infrared and DFT computations

    NASA Astrophysics Data System (ADS)

    Sundararajan, K.; Gopi, R.; Ramanathan, N.

    2016-10-01

    Conformations of propargyl alcohol (PA) were studied using matrix isolation infrared spectroscopy. DFT computations using 6-311++G(d,p) basis set on the PA molecule identified two minima; gauche (g-PA) and trans (t-PA). Comparison of infrared spectra of PA trapped in Ar, N2 and Xe matrices with computations showed the evidence of the ground state g-PA conformer. Four minima were optimized on the potential energy surface for the hydrogen-bonded interaction of g-PA and acetylene (C2H2), corresponding to complex A (Csbnd H⋯O), complex B (Osbnd H⋯π) and complex C and D (Csbnd H⋯π). The structure, energies and the vibrational wavenumbers were computed for these complexes at B3LYP/6-311++G (d,p) level of theory. The infrared spectra of the hydrogen-bonded complexes between C2H2 and g-PA were studied in Ar matrix. The infrared spectra recorded under matrix isolation conditions revealed the formation of two types of complexes A (Csbnd H⋯O) and B (Osbnd H⋯π). Formation of these complexes was evidenced from the shifts in the vibrational wavenumber of the modes involving the C2H2 and PA submolecules.

  16. Matrix assisted ionization: new aromatic and nonaromatic matrix compounds producing multiply charged lipid, peptide, and protein ions in the positive and negative mode observed directly from surfaces.

    PubMed

    Li, Jing; Inutan, Ellen D; Wang, Beixi; Lietz, Christopher B; Green, Daniel R; Manly, Cory D; Richards, Alicia L; Marshall, Darrell D; Lingenfelter, Steven; Ren, Yue; Trimpin, Sarah

    2012-10-01

    Matrix assisted inlet ionization (MAII) is a method in which a matrix:analyte mixture produces mass spectra nearly identical to electrospray ionization without the application of a voltage or the use of a laser as is required in laserspray ionization (LSI), a subset of MAII. In MAII, the sample is introduced by, for example, tapping particles of dried matrix:analyte into the inlet of the mass spectrometer and, therefore, permits the study of conditions pertinent to the formation of multiply charged ions without the need of absorption at a laser wavelength. Crucial for the production of highly charged ions are desolvation conditions to remove matrix molecules from charged matrix:analyte clusters. Important factors affecting desolvation include heat, vacuum, collisions with gases and surfaces, and even radio frequency fields. Other parameters affecting multiply charged ion production is sample preparation, including pH and solvent composition. Here, findings from over 100 compounds found to produce multiply charged analyte ions using MAII with the inlet tube set at 450 °C are presented. Of the compounds tested, many have -OH or -NH(2) functionality, but several have neither (e.g., anthracene), nor aromaticity or conjugation. Binary matrices are shown to be applicable for LSI and solvent-free sample preparation can be applied to solubility restricted compounds, and matrix compounds too volatile to allow drying from common solvents. Our findings suggest that the physical properties of the matrix such as its morphology after evaporation of the solvent, its propensity to evaporate/sublime, and its acidity are more important than its structure and functional groups.

  17. BSR: B-spline atomic R-matrix codes

    NASA Astrophysics Data System (ADS)

    Zatsarinny, Oleg

    2006-02-01

    BSR is a general program to calculate atomic continuum processes using the B-spline R-matrix method, including electron-atom and electron-ion scattering, and radiative processes such as bound-bound transitions, photoionization and polarizabilities. The calculations can be performed in LS-coupling or in an intermediate-coupling scheme by including terms of the Breit-Pauli Hamiltonian. New version program summaryTitle of program: BSR Catalogue identifier: ADWY Program summary URL:http://cpc.cs.qub.ac.uk/summaries/ADWY Program obtainable from: CPC Program Library, Queen's University of Belfast, N. Ireland Computers on which the program has been tested: Microway Beowulf cluster; Compaq Beowulf cluster; DEC Alpha workstation; DELL PC Operating systems under which the new version has been tested: UNIX, Windows XP Programming language used: FORTRAN 95 Memory required to execute with typical data: Typically 256-512 Mwords. Since all the principal dimensions are allocatable, the available memory defines the maximum complexity of the problem No. of bits in a word: 8 No. of processors used: 1 Has the code been vectorized or parallelized?: no No. of lines in distributed program, including test data, etc.: 69 943 No. of bytes in distributed program, including test data, etc.: 746 450 Peripherals used: scratch disk store; permanent disk store Distribution format: tar.gz Nature of physical problem: This program uses the R-matrix method to calculate electron-atom and electron-ion collision processes, with options to calculate radiative data, photoionization, etc. The calculations can be performed in LS-coupling or in an intermediate-coupling scheme, with options to include Breit-Pauli terms in the Hamiltonian. Method of solution: The R-matrix method is used [P.G. Burke, K.A. Berrington, Atomic and Molecular Processes: An R-Matrix Approach, IOP Publishing, Bristol, 1993; P.G. Burke, W.D. Robb, Adv. At. Mol. Phys. 11 (1975) 143; K.A. Berrington, W.B. Eissner, P.H. Norrington, Comput

  18. METCAN-PC - METAL MATRIX COMPOSITE ANALYZER

    NASA Technical Reports Server (NTRS)

    Murthy, P. L.

    1994-01-01

    High temperature metal matrix composites offer great potential for use in advanced aerospace structural applications. The realization of this potential however, requires concurrent developments in (1) a technology base for fabricating high temperature metal matrix composite structural components, (2) experimental techniques for measuring their thermal and mechanical characteristics, and (3) computational methods to predict their behavior. METCAN (METal matrix Composite ANalyzer) is a computer program developed to predict this behavior. METCAN can be used to computationally simulate the non-linear behavior of high temperature metal matrix composites (HT-MMC), thus allowing the potential payoff for the specific application to be assessed. It provides a comprehensive analysis of composite thermal and mechanical performance. METCAN treats material nonlinearity at the constituent (fiber, matrix, and interphase) level, where the behavior of each constituent is modeled accounting for time-temperature-stress dependence. The composite properties are synthesized from the constituent instantaneous properties by making use of composite micromechanics and macromechanics. Factors which affect the behavior of the composite properties include the fabrication process variables, the fiber and matrix properties, the bonding between the fiber and matrix and/or the properties of the interphase between the fiber and matrix. The METCAN simulation is performed as point-wise analysis and produces composite properties which are readily incorporated into a finite element code to perform a global structural analysis. After the global structural analysis is performed, METCAN decomposes the composite properties back into the localized response at the various levels of the simulation. At this point the constituent properties are updated and the next iteration in the analysis is initiated. This cyclic procedure is referred to as the integrated approach to metal matrix composite analysis. METCAN

  19. G-quadruplexes and helicases

    PubMed Central

    Mendoza, Oscar; Bourdoncle, Anne; Boulé, Jean-Baptiste; Brosh, Robert M.; Mergny, Jean-Louis

    2016-01-01

    Guanine-rich DNA strands can fold in vitro into non-canonical DNA structures called G-quadruplexes. These structures may be very stable under physiological conditions. Evidence suggests that G-quadruplex structures may act as ‘knots’ within genomic DNA, and it has been hypothesized that proteins may have evolved to remove these structures. The first indication of how G-quadruplex structures could be unfolded enzymatically came in the late 1990s with reports that some well-known duplex DNA helicases resolved these structures in vitro. Since then, the number of studies reporting G-quadruplex DNA unfolding by helicase enzymes has rapidly increased. The present review aims to present a general overview of the helicase/G-quadruplex field. PMID:26883636

  20. G-quadruplexes and helicases.

    PubMed

    Mendoza, Oscar; Bourdoncle, Anne; Boulé, Jean-Baptiste; Brosh, Robert M; Mergny, Jean-Louis

    2016-03-18

    Guanine-rich DNA strands can fold in vitro into non-canonical DNA structures called G-quadruplexes. These structures may be very stable under physiological conditions. Evidence suggests that G-quadruplex structures may act as 'knots' within genomic DNA, and it has been hypothesized that proteins may have evolved to remove these structures. The first indication of how G-quadruplex structures could be unfolded enzymatically came in the late 1990s with reports that some well-known duplex DNA helicases resolved these structures in vitro. Since then, the number of studies reporting G-quadruplex DNA unfolding by helicase enzymes has rapidly increased. The present review aims to present a general overview of the helicase/G-quadruplex field.

  1. Inelastic deformation of metal matrix composites

    NASA Technical Reports Server (NTRS)

    Lissenden, C. J.; Herakovich, C. T.; Pindera, M-J.

    1993-01-01

    A theoretical model capable of predicting the thermomechanical response of continuously reinforced metal matrix composite laminates subjected to multiaxial loading was developed. A micromechanical model is used in conjunction with nonlinear lamination theory to determine inelastic laminae response. Matrix viscoplasticity, residual stresses, and damage to the fiber/matrix interfacial zone are explicitly included in the model. The representative cell of the micromechanical model is considered to be in a state of generalized plane strain, enabling a quasi two-dimensional analysis to be performed. Constant strain finite elements are formulated with elastic-viscoplastic constitutive equations. Interfacial debonding is incorporated into the model through interface elements based on the interfacial debonding theory originally presented by Needleman, and modified by Tvergaard. Nonlinear interfacial constitutive equations relate interfacial tractions to displacement discontinuities at the interface. Theoretical predictions are compared with the results of an experimental program conducted on silicon carbide/titanium (SiC/Ti) unidirectional, (O4), and angle-ply, (+34)(sub s), tubular specimens. Multiaxial loading included increments of axial tension, compression, torque, and internal pressure. Loadings were chosen in an effort to distinguish inelastic deformation due to damage from matrix plasticity and separate time-dependent effects from time-independent effects. Results show that fiber/matrix debonding is nonuniform throughout the composite and is a major factor in the effective response. Also, significant creep behavior occurs at relatively low applied stress levels at room temperature.

  2. Max-min distance nonnegative matrix factorization.

    PubMed

    Wang, Jim Jing-Yan; Gao, Xin

    2015-01-01

    Nonnegative Matrix Factorization (NMF) has been a popular representation method for pattern classification problems. It tries to decompose a nonnegative matrix of data samples as the product of a nonnegative basis matrix and a nonnegative coefficient matrix. The columns of the coefficient matrix can be used as new representations of these data samples. However, traditional NMF methods ignore class labels of the data samples. In this paper, we propose a novel supervised NMF algorithm to improve the discriminative ability of the new representation by using the class labels. Using the class labels, we separate all the data sample pairs into within-class pairs and between-class pairs. To improve the discriminative ability of the new NMF representations, we propose to minimize the maximum distance of the within-class pairs in the new NMF space, and meanwhile to maximize the minimum distance of the between-class pairs. With this criterion, we construct an objective function and optimize it with regard to basis and coefficient matrices, and slack variables alternatively, resulting in an iterative algorithm. The proposed algorithm is evaluated on three pattern classification problems and experiment results show that it outperforms the state-of-the-art supervised NMF methods.

  3. Convex Banding of the Covariance Matrix.

    PubMed

    Bien, Jacob; Bunea, Florentina; Xiao, Luo

    2016-01-01

    We introduce a new sparse estimator of the covariance matrix for high-dimensional models in which the variables have a known ordering. Our estimator, which is the solution to a convex optimization problem, is equivalently expressed as an estimator which tapers the sample covariance matrix by a Toeplitz, sparsely-banded, data-adaptive matrix. As a result of this adaptivity, the convex banding estimator enjoys theoretical optimality properties not attained by previous banding or tapered estimators. In particular, our convex banding estimator is minimax rate adaptive in Frobenius and operator norms, up to log factors, over commonly-studied classes of covariance matrices, and over more general classes. Furthermore, it correctly recovers the bandwidth when the true covariance is exactly banded. Our convex formulation admits a simple and efficient algorithm. Empirical studies demonstrate its practical effectiveness and illustrate that our exactly-banded estimator works well even when the true covariance matrix is only close to a banded matrix, confirming our theoretical results. Our method compares favorably with all existing methods, in terms of accuracy and speed. We illustrate the practical merits of the convex banding estimator by showing that it can be used to improve the performance of discriminant analysis for classifying sound recordings.

  4. Transfer matrix representation for periodic planar media

    NASA Astrophysics Data System (ADS)

    Parrinello, A.; Ghiringhelli, G. L.

    2016-06-01

    Sound transmission through infinite planar media characterized by in-plane periodicity is faced by exploiting the free wave propagation on the related unit cells. An appropriate through-thickness transfer matrix, relating a proper set of variables describing the acoustic field at the two external surfaces of the medium, is derived by manipulating the dynamic stiffness matrix related to a finite element model of the unit cell. The adoption of finite element models avoids analytical modeling or the simplification on geometry or materials. The obtained matrix is then used in a transfer matrix method context, making it possible to combine the periodic medium with layers of different nature and to treat both hard-wall and semi-infinite fluid termination conditions. A finite sequence of identical sub-layers through the thickness of the medium can be handled within the transfer matrix method, significantly decreasing the computational burden. Transfer matrices obtained by means of the proposed method are compared with analytical or equivalent models, in terms of sound transmission through barriers of different nature.

  5. Nuclear matrix proteins in human colon cancer.

    PubMed Central

    Keesee, S K; Meneghini, M D; Szaro, R P; Wu, Y J

    1994-01-01

    The nuclear matrix is the nonchromatin scaffolding of the nucleus. This structure confers nuclear shape, organizes chromatin, and appears to contain important regulatory proteins. Tissue specific nuclear matrix proteins have been found in the rat, mouse, and human. In this study we compared high-resolution two-dimensional gel electropherograms of nuclear matrix protein patterns found in human colon tumors with those from normal colon epithelia. Tumors were obtained from 18 patients undergoing partial colectomy for adenocarcinoma of the colon and compared with tissue from 10 normal colons. We have identified at least six proteins which were present in 18 of 18 colon tumors and 0 of 10 normal tissues, as well as four proteins present in 0 of 18 tumors and in 10 of 10 normal tissues. These data, which corroborate similar findings of cancer-specific nuclear matrix proteins in prostate and breast, suggest that nuclear matrix proteins may serve as important markers for at least some types of cancer. Images PMID:8127905

  6. Thermal stress effects in intermetallic matrix composites

    NASA Technical Reports Server (NTRS)

    Wright, P. K.; Sensmeier, M. D.; Kupperman, D. S.; Wadley, H. N. G.

    1993-01-01

    Intermetallic matrix composites develop residual stresses from the large thermal expansion mismatch (delta-alpha) between the fibers and matrix. This work was undertaken to: establish improved techniques to measure these thermal stresses in IMC's; determine residual stresses in a variety of IMC systems by experiments and modeling; and, determine the effect of residual stresses on selected mechanical properties of an IMC. X ray diffraction (XRD), neutron diffraction (ND), synchrotron XRD (SXRD), and ultrasonics (US) techniques for measuring thermal stresses in IMC were examined and ND was selected as the most promising technique. ND was demonstrated on a variety of IMC systems encompassing Ti- and Ni-base matrices, SiC, W, and Al2O3 fibers, and different fiber fractions (Vf). Experimental results on these systems agreed with predictions of a concentric cylinder model. In SiC/Ti-base systems, little yielding was found and stresses were controlled primarily by delta-alpha and Vf. In Ni-base matrix systems, yield strength of the matrix and Vf controlled stress levels. The longitudinal residual stresses in SCS-6/Ti-24Al-llNb composite were modified by thermomechanical processing. Increasing residual stress decreased ultimate tensile strength in agreement with model predictions. Fiber pushout strength showed an unexpected inverse correlation with residual stress. In-plane shear yield strength showed no dependence on residual stress. Higher levels of residual tension led to higher fatigue crack growth rates, as suggested by matrix mean stress effects.

  7. Anyons and matrix product operator algebras

    NASA Astrophysics Data System (ADS)

    Bultinck, N.; Mariën, M.; Williamson, D. J.; Şahinoğlu, M. B.; Haegeman, J.; Verstraete, F.

    2017-03-01

    Quantum tensor network states and more particularly projected entangled-pair states provide a natural framework for representing ground states of gapped, topologically ordered systems. The defining feature of these representations is that topological order is a consequence of the symmetry of the underlying tensors in terms of matrix product operators. In this paper, we present a systematic study of those matrix product operators, and show how this relates entanglement properties of projected entangled-pair states to the formalism of fusion tensor categories. From the matrix product operators we construct a C∗-algebra and find that topological sectors can be identified with the central idempotents of this algebra. This allows us to construct projected entangled-pair states containing an arbitrary number of anyons. Properties such as topological spin, the S matrix, fusion and braiding relations can readily be extracted from the idempotents. As the matrix product operator symmetries are acting purely on the virtual level of the tensor network, the ensuing Wilson loops are not fattened when perturbing the system, and this opens up the possibility of simulating topological theories away from renormalization group fixed points. We illustrate the general formalism for the special cases of discrete gauge theories and string-net models.

  8. Aluminum matrix texture in Al-Al3Ti functionally graded materials analyzed by electron back-scattering diffraction

    NASA Astrophysics Data System (ADS)

    Watanabe, Yoshimi; Sequeira, Paulo D.; Sato, Hisashi; Inamura, Tomonari; Hosoda, Hideki

    2016-01-01

    Al matrix functionally graded materials (FGMs) with oriented Al3Ti platelets were fabricated by a centrifugal solid-particle method. The applied centrifugal forces were 30, 60, and 120G (units of gravity). The orientation and volume fraction gradients of the Al3Ti platelets within the samples were measured. Since a good lattice correspondence was reported for the close-packed directions and the close-packed planes between Al and Al3Ti, the Al matrix in the Al-Al3Ti FGMs fabricated by the centrifugal solid-particle method should have some texture. Al matrix texture was, therefore, analyzed by electron back-scattering diffraction (EBSD). Analysis of the resulting pole figures indicates a preferred orientation along the (200) plane for the Al matrix crystals. Furthermore, increasing the applied centrifugal force enhances the orientation effect. A correlation appears to exist between platelet orientation and the preferred texture of the Al matrix.

  9. G-ruption: The third international meeting on G-quadruplex and G-assembly

    PubMed Central

    Yatsunyk, Liliya A.; Bryan, Tracy M.; Johnson, F. Brad

    2013-01-01

    A three and a half day conference focusing on nucleic acid structures called G-quadruplexes (G4s) and other guanine-based assemblies was held in Sorrento, Italy (June 28–July 1, 2011) and featured 35 invited talks and over 89 posters. The G-quadruplex field continues to expand at an explosive rate with the emergence of new connections to biology, chemistry, physics, and nanotechnology. Following the trend established by the previous two international G4 meetings, the conference touched upon all these areas and facilitated productive exchanges of ideas between researchers from all over the world. PMID:22974982

  10. A phenomenological cohesive model for the macroscopic simulation of cell-matrix adhesions.

    PubMed

    Cóndor, M; García-Aznar, J M

    2017-02-17

    Cell adhesion is crucial for cells to not only physically interact with each other but also sense their microenvironment and respond accordingly. In fact, adherent cells can generate physical forces that are transmitted to the surrounding matrix, regulating the formation of cell-matrix adhesions. The main purpose of this work is to develop a computational model to simulate the dynamics of cell-matrix adhesions through a cohesive formulation within the framework of the finite element method and based on the principles of continuum damage mechanics. This model enables the simulation of the mechanical adhesion between cell and extracellular matrix (ECM) as regulated by local multidirectional forces and thus predicts the onset and growth of the adhesion. In addition, this numerical approach allows the simulation of the cell as a whole, as it models the complete mechanical interaction between cell and ECM. As a result, we can investigate and quantify how different mechanical conditions in the cell (e.g., contractile forces, actin cytoskeletal properties) or in the ECM (e.g., stiffness, external forces) can regulate the dynamics of cell-matrix adhesions.

  11. Ultrasonic array imaging of multilayer structures using full matrix capture and extended phase shift migration

    NASA Astrophysics Data System (ADS)

    Wu, Haiteng; Chen, Jian; Yang, Keji; Hu, Xuxiao

    2016-04-01

    Multilayer structures have been widely used in industrial fields, and non-destructive evaluation of these structures is of great importance to assure their quality and performance. Recently, ultrasonic array imaging using full matrix capture, e.g. the total focusing method (TFM), has been shown to increase sensitivity to small defects and improve imaging resolution in homogeneous media. However, it cannot be applied to multilayer structures directly, due to the sound velocity variation in different layers and because refraction occurs at layer interfaces, which gives rise to difficulties in determining the propagation path and time. To overcome these problems, an extended phase shift migration (EPSM) is proposed for the full matrix imaging of multilayer structures in this paper. Based on the theory of phase shift migration for monostatic pulse-echo imaging, full matrix imaging using EPSM is derived by extrapolating the wavefields in both transmission and reception, and extended to the multilayer case. The performance of the proposed algorithm is evaluated by full matrix imaging of a two-layer structure with side-drilled holes conducted both in the simulation and the experiment. The results verify that the proposed algorithm is capable of full matrix imaging of a layered structure with a high resolution and signal-to-noise ratio. For comparison, full matrix imaging using the TFM with root-mean-squared velocity is also performed, and the results demonstrate that the proposed algorithm is superior to the TFM in improving both the image quality and resolution.

  12. Effect of Cyclic Thermo-Mechanical Loads on Fatigue Reliability in Polymer Matrix Composites

    NASA Technical Reports Server (NTRS)

    Shah, A. R.; Murthy, P. L. N.; Chamis, C. C.

    1996-01-01

    A methodology to compute probabilistic fatigue life of polymer matrix laminated composites has been developed and demonstrated. Matrix degradation effects caused by long term environmental exposure and mechanical/thermal cyclic loads are accounted for in the simulation process. A unified time-temperature-stress dependent multi-factor interaction relationship developed at NASA Lewis Research Center has been used to model the degradation/aging of material properties due to cyclic loads. The fast probability integration method is used to compute probabilistic distribution of response. Sensitivities of fatigue life reliability to uncertainties in the primitive random variables (e.g., constituent properties, fiber volume ratio, void volume ratio, ply thickness, etc.) computed and their significance in the reliability- based design for maximum life is discussed. The effect of variation in the thermal cyclic loads on the fatigue reliability for a (0/+/- 45/90)(sub s) graphite/epoxy laminate with a ply thickness of 0.127 mm, with respect to impending failure modes has been studied. The results show that, at low mechanical cyclic loads and low thermal cyclic amplitudes, fatigue life for 0.999 reliability is most sensitive to matrix compressive strength, matrix modulus, thermal expansion coefficient, and ply thickness. Whereas at high mechanical cyclic loads and high thermal cyclic amplitudes, fatigue life at 0.999 reliability is more sensitive to the shear strength of matrix, longitudinal fiber modulus, matrix modulus, and ply thickness.

  13. M* G€* GÇ* * $ .25 ÿÿg@ðÿg¹éÿgXîÿgÛùÿg$*æ*æ}*f**æ ...

    EPA Pesticide Factsheets

    2015-09-01

    ... fy*æõùÿç*ûÿg**æ ÿÿç¾ûÿgÛæ¼*æ¤*f*fÐüÿg¬ýÿg‚ýÿçäüÿçQýÿç¼*æ2*f#*f× ýÿç=úÿgpúÿçáûÿgùýÿç_æÑ*æR. ... æú. fQÿÿç ÷ÿg³øÿçÊûÿç;úÿg*ûÿçÖ*f#*f*. ...

  14. Damage initiation, progression and failure of polymer matrix composites due to manufacturing induced defects

    NASA Astrophysics Data System (ADS)

    Chowdhury, Khairul Alam

    In polymer matrix composites (PMCs) manufacturing processes can induce defects, e.g., voids, fiber misalignment, irregular fiber distribution in the cross-section and broken fibers. The effects of such defects can be beneficial or deleterious depending on whether they cause failure suppression or enhancement by localized deformation processes e.g., crazing, shear yielding and fiber-matrix debonding. In this study, a computational approach is formulated and implemented to develop solutions for general boundary-value problems for PMC microstructures that accounts for micromechanics-based constitutive relations including fine scale mechanisms of material failure. The defects considered are voids, and the microstructure is explicitly represented by a distribution of fibers and voids embedded in a polymer matrix. Fiber is modeled as a linearly elastic material while the polymer matrix is modeled as an elastic-viscoplastic material. Two distinct models for the matrix behavior are implemented: (i) Drucker-Prager type Bodner model that accounts for rate and pressure-sensitivity, and (ii) improved macromolecular constitutive model that also accounts for temperature dependence, small-strain softening and large-strain hardening. Damage is simulated by the Gearing-Anand craze model as a reference model and by a new micromechanical craze model, developed to account for craze initiation, growth and breakdown. Critical dilatational energy density criterion is utilized to predict fiber-matrix debonding through cavitation induced matrix cracking. An extensive parametric study is conducted in which the roles of void shape, size and distribution relative to fiber in determining damage initiation and evolution are investigated under imposed temperature and strain rate conditions. Results show there are significant effects of voids on microstructural damage as well as on the overall deformational and failure response of composites.

  15. Liver functions in silica-exposed workers in Egypt: possible role of matrix remodeling and immunological factors

    PubMed Central

    Zawilla, Nermin; Taha, Fatma; Ibrahim, Yasser

    2014-01-01

    Background: Brick manufacturing constitutes an important industrial sector in Egypt with considerable exposure to silica. Objectives: We aimed for evaluating hepatic functions in silica-exposed workers in the clay brick industry, and the possible role of matrix remodeling and immunological factors. Methods: A case–control study, 87 workers as exposed and 45 as control subjects. Questionnaire, clinical examination, and laboratory investigations: liver functions, matrix metalloproteinase-9, immunoglobulins G and E, and anti-liver kidney microsomal antibody. Results: In the exposed workers, mean levels of liver functions, matrix metalloproteinase-9 (MMP-9), and IgG and IgE were significantly higher. In the silicotic subgroup the mean level of GGT was almost twice the level in the non-silicotic subjects. Logistic regression showed that abnormal GGT and ALT were associated with production workers. Conclusion: Workers in the clay brick industry showed evidence of liver disease that could be related to matrix remodeling. PMID:24999850

  16. Cache oblivious storage and access heuristics for blocked matrix-matrix multiplication

    SciTech Connect

    Bock, Nicolas; Rubensson, Emanuel H; Niklasson, Anders M N; Challacombe, Matt; Salek, Pawel

    2008-01-01

    The authors investigate effects of ordering in blocked matrix-matrix multiplication. They find that submatrices do not have to be stored contiguously in memory in order to achieve near optimal performance. They also find a good choice of execution order of submatrix operations can lead to a speedup of up to four times for small block sizes.

  17. Spectral density of the correlation matrix of factor models: a random matrix theory approach.

    PubMed

    Lillo, F; Mantegna, R N

    2005-07-01

    We studied the eigenvalue spectral density of the correlation matrix of factor models of multivariate time series. By making use of the random matrix theory, we analytically quantified the effect of statistical uncertainty on the spectral density due to the finiteness of the sample. We considered a broad range of models, ranging from one-factor models to hierarchical multifactor models.

  18. High T(g) Polyimides

    NASA Technical Reports Server (NTRS)

    Chuang, Kathy

    2001-01-01

    The use of high temperature polymer matrix composites in aerospace applications has expanded steadily over the past 30 years, due to the increasing demand of replacing metal parts with light weight composite materials for fuel efficiency and bigger payloads in the aircraft and the space transportation vehicles. Polyimide/carbon fiber composites, especially, have been regarded as major high temperature matrix materials, based on their outstanding performance in terms of heat resistance, high strength-to-weight ratio and property retention compared with epoxies (177 C/350 F) and bismaleimides (232 C/450 F). Traditional, then-neoplastic polyimides were prepared from dianhydrides and diamines in N-methyl-2-pyrrolidinone (NMP) at room temperature to form the polyamic acids, which were then imidized at 150 C to yield polyimides. However, the high-boiling solvent (NMP, BP= 202 C) is very difficult to remove, leading to the formation of voids during composite fabrication. In the early 1970's, PMR addition curing polyimides with reactive endcaps were developed at the Lewis Research Center (renamed NASA Glenn) to ensure the easy processing of imide oligomers in methanol during composite fabrication.

  19. Matrix elements from moments of correlation functions

    SciTech Connect

    Chang, Chia Cheng; Bouchard, Chris; Orginos, Konstantinos; Richards, David G.

    2016-10-01

    Momentum-space derivatives of matrix elements can be related to their coordinate-space moments through the Fourier transform. We derive these expressions as a function of momentum transfer Q2 for asymptotic in/out states consisting of a single hadron. We calculate corrections to the finite volume moments by studying the spatial dependence of the lattice correlation functions. This method permits the computation of not only the values of matrix elements at momenta accessible on the lattice, but also the momentum-space derivatives, providing {\\it a priori} information about the Q2 dependence of form factors. As a specific application we use the method, at a single lattice spacing and with unphysically heavy quarks, to directly obtain the slope of the isovector form factor at various Q2, whence the isovector charge radius. The method has potential application in the calculation of any hadronic matrix element with momentum transfer, including those relevant to hadronic weak decays.

  20. Decorin modulates matrix mineralization in vitro

    NASA Technical Reports Server (NTRS)

    Mochida, Yoshiyuki; Duarte, Wagner R.; Tanzawa, Hideki; Paschalis, Eleftherios P.; Yamauchi, Mitsuo

    2003-01-01

    Decorin (DCN), a member of small leucine-rich proteoglycans, is known to modulate collagen fibrillogenesis. In order to investigate the potential roles of DCN in collagen matrix mineralization, several stable osteoblastic cell clones expressing higher (sense-DCN, S-DCN) and lower (antisense-DCN, As-DCN) levels of DCN were generated and the mineralized nodules formed by these clones were characterized. In comparison with control cells, the onset of mineralization by S-DCN clones was significantly delayed; whereas it was markedly accelerated and the number of mineralized nodules was significantly increased in As-DCN clones. The timing of mineralization was inversely correlated with the level of DCN synthesis. In these clones, the patterns of cell proliferation and differentiation appeared unaffected. These results suggest that DCN may act as an inhibitor of collagen matrix mineralization, thus modulating the timing of matrix mineralization.

  1. Google matrix analysis of directed networks

    NASA Astrophysics Data System (ADS)

    Ermann, Leonardo; Frahm, Klaus M.; Shepelyansky, Dima L.

    2015-10-01

    In the past decade modern societies have developed enormous communication and social networks. Their classification and information retrieval processing has become a formidable task for the society. Because of the rapid growth of the World Wide Web, and social and communication networks, new mathematical methods have been invented to characterize the properties of these networks in a more detailed and precise way. Various search engines extensively use such methods. It is highly important to develop new tools to classify and rank a massive amount of network information in a way that is adapted to internal network structures and characteristics. This review describes the Google matrix analysis of directed complex networks demonstrating its efficiency using various examples including the World Wide Web, Wikipedia, software architectures, world trade, social and citation networks, brain neural networks, DNA sequences, and Ulam networks. The analytical and numerical matrix methods used in this analysis originate from the fields of Markov chains, quantum chaos, and random matrix theory.

  2. t matrix of metallic wire structures

    SciTech Connect

    Zhan, T. R. Chui, S. T.

    2014-04-14

    To study the electromagnetic resonance and scattering properties of complex structures of which metallic wire structures are constituents within multiple scattering theory, the t matrix of individual structures is needed. We have recently developed a rigorous and numerically efficient equivalent circuit theory in which retardation effects are taken into account for metallic wire structures. Here, we show how the t matrix can be calculated analytically within this theory. We illustrate our method with the example of split ring resonators. The density of states and cross sections for scattering and absorption are calculated, which are shown to be remarkably enhanced at resonant frequencies. The t matrix serves as the basic building block to evaluate the interaction of wire structures within the framework of multiple scattering theory. This will open the door to efficient design and optimization of assembly of wire structures.

  3. Snapshot retinal imaging Mueller matrix polarimeter

    NASA Astrophysics Data System (ADS)

    Wang, Yifan; Kudenov, Michael; Kashani, Amir; Schwiegerling, Jim; Escuti, Michael

    2015-09-01

    Early diagnosis of glaucoma, which is a leading cause for visual impairment, is critical for successful treatment. It has been shown that Imaging polarimetry has advantages in early detection of structural changes in the retina. Here, we theoretically and experimentally present a snapshot Mueller Matrix Polarimeter fundus camera, which has the potential to record the polarization-altering characteristics of retina with a single snapshot. It is made by incorporating polarization gratings into a fundus camera design. Complete Mueller Matrix data sets can be obtained by analyzing the polarization fringes projected onto the image plane. In this paper, we describe the experimental implementation of the snapshot retinal imaging Mueller matrix polarimeter (SRIMMP), highlight issues related to calibration, and provide preliminary images acquired from the camera.

  4. t matrix of metallic wire structures

    NASA Astrophysics Data System (ADS)

    Zhan, T. R.; Chui, S. T.

    2014-04-01

    To study the electromagnetic resonance and scattering properties of complex structures of which metallic wire structures are constituents within multiple scattering theory, the t matrix of individual structures is needed. We have recently developed a rigorous and numerically efficient equivalent circuit theory in which retardation effects are taken into account for metallic wire structures. Here, we show how the t matrix can be calculated analytically within this theory. We illustrate our method with the example of split ring resonators. The density of states and cross sections for scattering and absorption are calculated, which are shown to be remarkably enhanced at resonant frequencies. The t matrix serves as the basic building block to evaluate the interaction of wire structures within the framework of multiple scattering theory. This will open the door to efficient design and optimization of assembly of wire structures.

  5. Electrolyte matrix for molten carbonate fuel cells

    DOEpatents

    Huang, Chao M.; Yuh, Chao-Yi

    1999-01-01

    A matrix for a carbonate electrolyte including a support material and an additive constituent having a relatively low melting temperature and a relatively high coefficient of thermal expansion. The additive constituent is from 3 to 45 weight percent of the matrix and is formed from raw particles whose diameter is in a range of 0.1 .mu.m to 20 .mu.m and whose aspect ratio is in a range of 1 to 50. High energy intensive milling is used to mix the support material and additive constituent during matrix formation. Also disclosed is the use of a further additive constituent comprising an alkaline earth containing material. The further additive is mixed with the support material using high energy intensive milling.

  6. Electrolyte matrix for molten carbonate fuel cells

    DOEpatents

    Huang, C.M.; Yuh, C.Y.

    1999-02-09

    A matrix is described for a carbonate electrolyte including a support material and an additive constituent having a relatively low melting temperature and a relatively high coefficient of thermal expansion. The additive constituent is from 3 to 45 weight percent of the matrix and is formed from raw particles whose diameter is in a range of 0.1 {micro}m to 20 {micro}m and whose aspect ratio is in a range of 1 to 50. High energy intensive milling is used to mix the support material and additive constituent during matrix formation. Also disclosed is the use of a further additive constituent comprising an alkaline earth containing material. The further additive is mixed with the support material using high energy intensive milling. 5 figs.

  7. Dentin Matrix Proteins in Bone Tissue Engineering.

    PubMed

    Ravindran, Sriram; George, Anne

    2015-01-01

    Dentin and bone are mineralized tissue matrices comprised of collagen fibrils and reinforced with oriented crystalline hydroxyapatite. Although both tissues perform different functionalities, they are assembled and orchestrated by mesenchymal cells that synthesize both collagenous and noncollagenous proteins albeit in different proportions. The dentin matrix proteins (DMPs) have been studied in great detail in recent years due to its inherent calcium binding properties in the extracellular matrix resulting in tissue calcification. Recent studies have shown that these proteins can serve both as intracellular signaling proteins leading to induction of stem cell differentiation and also function as nucleating proteins in the extracellular matrix. These properties make the DMPs attractive candidates for bone and dentin tissue regeneration. This chapter will provide an overview of the DMPs, their functionality and their proven and possible applications with respect to bone tissue engineering.

  8. Matrix theory compactifications on twisted tori

    NASA Astrophysics Data System (ADS)

    Chatzistavrakidis, Athanasios; Jonke, Larisa

    2012-05-01

    We study compactifications of Matrix theory on twisted tori and noncommutative versions of them. As a first step, we review the construction of multidimensional twisted tori realized as nilmanifolds based on certain nilpotent Lie algebras. Subsequently, matrix compactifications on tori are revisited, and the previously known results are supplemented with a background of a noncommutative torus with nonconstant noncommutativity and an underlying nonassociative structure on its phase space. Next, we turn our attention to three- and six-dimensional twisted tori, and we describe consistent backgrounds of Matrix theory on them by stating and solving the conditions which describe the corresponding compactification. Both commutative and noncommutative solutions are found in all cases. Finally, we comment on the correspondence among the obtained solutions and flux compactifications of 11-dimensional supergravity, as well as on relations among themselves, such as Seiberg-Witten maps and T-duality.

  9. Pneumococcal MSCRAMM targeting of the extracellular matrix

    PubMed Central

    Paterson, Gavin K.; Orihuela, Carlos J.

    2010-01-01

    The attachment of bacteria to host cells and tissues and their subsequent invasion and dissemination are key processes during disease pathogenesis. In this issue of Molecular Microbiology, Jensch and co-workers provide further molecular insight into these events during infection with the Gram-positive bacterium Streptococcus pneumoniae. Their characterization of PavB, a bacterial surface protein with orthologues in other streptococci, shows it to bind the extracellar matrix components fibronection and plasminogen by virtue of repetitive sequences designated Streptococcal Surface Repeats (SSURE). In mice, a pavB mutant showed reduced nasopharyngeal colonisation and was attenuated in a lung infection model. As discussed here in the context of the pneumococcus, the study of PavB highlights the central role during microbal pathogenesis of targetting the extracellular matrix by so-called MSCRAMMs (microbial surface components recognizing adhesive matrix molecules). PMID:20444102

  10. Ethynylated aromatics as high temperature matrix resins

    NASA Technical Reports Server (NTRS)

    Hurwitz, Frances I.

    1986-01-01

    Difunctional and trifunctional arylacetylenes were used as monomers to form thermoset matrix resin composites. Composites can be hot pressed at 180 C to react 80 percent of the acetylene groups. Crosslinking is completed by postcuring at 350 C. The postcured resins are thermally stable to nominally 460 C in air. As a result of their high crosslink density, the matrix exhibits brittle failure when unaxial composites are tested in tension. Failure of both uniaxial tensile and flexural specimens occurs in shear at the fiber matrix interface. Tensile fracture stresses for 0 deg composites fabricated with 60 v/o Celion 6K graphite fiber were 827 MPa. The strain to failure was 0.5 percent. Composites fabricated with 8 harness satin Celion cloth (Fiberite 1133) and tested in tension also failed in shear at tensile stresses of 413 MPa.

  11. Improved high temperature resistant matrix resins

    NASA Technical Reports Server (NTRS)

    Chang, G. E.; Powell, S. H.; Jones, R. J.

    1983-01-01

    The objective was to develop organic matrix resins suitable for service at temperatures up to 644 K (700 F) and at air pressures up to 0.4 MPa (60 psia) for time durations of a minimum of 100 hours. Matrix resins capable of withstanding these extreme oxidative environmental conditions would lead to increased use of polymer matrix composites in aircraft engines and provide significant weight and cost savings. Six linear condensation, aromatic/heterocyclic polymers containing fluorinated and/or diphenyl linkages were synthesized. The thermo-oxidative stability of the resins was determined at 644 K and compressed air pressures up to 0.4 MPa. Two formulations, both containing perfluoroisopropylidene linkages in the polymer backbone structure, exhibited potential for 644 K service to meet the program objectives. Two other formulations could not be fabricated into compression molded zero defect specimens.

  12. Achondrogenesis type II, abnormalities of extracellular matrix.

    PubMed

    Horton, W A; Machado, M A; Chou, J W; Campbell, D

    1987-09-01

    Immune and lectin histochemical and microchemical methods were employed to study growth cartilage from seven cases of achondrogenesis type II (Langer-Saldino). The normal architecture of the epiphyseal and growth plate cartilage was replaced by a morphologically heterogeneous tissue. Some areas were comprised of vascular canals surrounded by extensive fibrous tissue and enlarged cells that had the appearance and histochemical characteristics of hypertrophic chondrocytes. Other areas contained a mixture of cells ranging from small to the enlarged chondrocytes. The extracellular matrix in the latter areas was more abundant and had characteristics of both precartilage mesenchymal matrix and typical cartilage matrix; it contained types I and II collagen, cartilage proteoglycan, fibronectin, and peanut agglutinin binding glycoconjugate(s). Peptide mapping of cyanogen bromide cartilage collagen peptides revealed the presence of types I and II collagen. These observations could be explained by a defect in the biosynthesis of type II collagen or in chondrocyte differentiation.

  13. Renormalon ambiguities in NRQCD operator matrix elements

    NASA Astrophysics Data System (ADS)

    Bodwin, Geoffrey T.; Chen, Yu-Qi

    1999-09-01

    We analyze the renormalon ambiguities that appear in factorization formulas in QCD. Our analysis contains a simple argument that the ambiguities in the short-distance coefficients and operator matrix elements are artifacts of dimensional-regularization factorization schemes and are absent in cutoff schemes. We also present a method for computing the renormalon ambiguities in operator matrix elements and apply it to a computation of the ambiguities in the matrix elements that appear in the NRQCD factorization formulas for the annihilation decays of S-wave quarkonia. Our results, combined with those of Braaten and Chen for the short-distance coefficients, provide an explicit demonstration that the ambiguities cancel in the physical decay rates. In addition, we analyze the renormalon ambiguities in the Gremm-Kapustin relation and in various definitions of the heavy-quark mass.

  14. Propulsive matrix of a helical flagellum

    NASA Astrophysics Data System (ADS)

    Zhang, He-Peng; Liu, Bin; Bruce, Rodenborn; Harry, L. Swinney

    2014-11-01

    We study the propulsion matrix of bacterial flagella numerically using slender body theory and the regularized Stokeslet method in a biologically relevant parameter regime. All three independent elements of the matrix are measured by computing propulsive force and torque generated by a rotating flagellum, and the drag force on a translating flagellum. Numerical results are compared with the predictions of resistive force theory, which is often used to interpret micro-organism propulsion. Neglecting hydrodynamic interactions between different parts of a flagellum in resistive force theory leads to both qualitative and quantitative discrepancies between the theoretical prediction of resistive force theory and the numerical results. We improve the original theory by empirically incorporating the effects of hydrodynamic interactions and propose new expressions for propulsive matrix elements that are accurate over the parameter regime explored.

  15. Brief announcement: Hypergraph parititioning for parallel sparse matrix-matrix multiplication

    SciTech Connect

    Ballard, Grey; Druinsky, Alex; Knight, Nicholas; Schwartz, Oded

    2015-01-01

    The performance of parallel algorithms for sparse matrix-matrix multiplication is typically determined by the amount of interprocessor communication performed, which in turn depends on the nonzero structure of the input matrices. In this paper, we characterize the communication cost of a sparse matrix-matrix multiplication algorithm in terms of the size of a cut of an associated hypergraph that encodes the computation for a given input nonzero structure. Obtaining an optimal algorithm corresponds to solving a hypergraph partitioning problem. Furthermore, our hypergraph model generalizes several existing models for sparse matrix-vector multiplication, and we can leverage hypergraph partitioners developed for that computation to improve application-specific algorithms for multiplying sparse matrices.

  16. Brief announcement: Hypergraph parititioning for parallel sparse matrix-matrix multiplication

    DOE PAGES

    Ballard, Grey; Druinsky, Alex; Knight, Nicholas; ...

    2015-01-01

    The performance of parallel algorithms for sparse matrix-matrix multiplication is typically determined by the amount of interprocessor communication performed, which in turn depends on the nonzero structure of the input matrices. In this paper, we characterize the communication cost of a sparse matrix-matrix multiplication algorithm in terms of the size of a cut of an associated hypergraph that encodes the computation for a given input nonzero structure. Obtaining an optimal algorithm corresponds to solving a hypergraph partitioning problem. Furthermore, our hypergraph model generalizes several existing models for sparse matrix-vector multiplication, and we can leverage hypergraph partitioners developed for that computationmore » to improve application-specific algorithms for multiplying sparse matrices.« less

  17. Thermal and mechanical behavior of metal matrix and ceramic matrix composites

    NASA Technical Reports Server (NTRS)

    Kennedy, John M. (Editor); Moeller, Helen H. (Editor); Johnson, W. S. (Editor)

    1990-01-01

    The present conference discusses local stresses in metal-matrix composites (MMCs) subjected to thermal and mechanical loads, the computational simulation of high-temperature MMCs' cyclic behavior, an analysis of a ceramic-matrix composite (CMC) flexure specimen, and a plasticity analysis of fibrous composite laminates under thermomechanical loads. Also discussed are a comparison of methods for determining the fiber-matrix interface frictional stresses of CMCs, the monotonic and cyclic behavior of an SiC/calcium aluminosilicate CMC, the mechanical and thermal properties of an SiC particle-reinforced Al alloy MMC, the temperature-dependent tensile and shear response of a graphite-reinforced 6061 Al-alloy MMC, the fiber/matrix interface bonding strength of MMCs, and fatigue crack growth in an Al2O3 short fiber-reinforced Al-2Mg matrix MMC.

  18. Bioengineering Human Myocardium on Native Extracellular Matrix

    PubMed Central

    Guyette, Jacques P.; Charest, Jonathan M; Mills, Robert W; Jank, Bernhard J.; Moser, Philipp T.; Gilpin, Sarah E.; Gershlak, Joshua R.; Okamoto, Tatsuya; Gonzalez, Gabriel; Milan, David J.; Gaudette, Glenn R.; Ott, Harald C.

    2015-01-01

    Rationale More than 25 million individuals suffer from heart failure worldwide, with nearly 4,000 patients currently awaiting heart transplantation in the United States. Donor organ shortage and allograft rejection remain major limitations with only about 2,500 hearts transplanted each year. As a theoretical alternative to allotransplantation, patient-derived bioartificial myocardium could provide functional support and ultimately impact the treatment of heart failure. Objective The objective of this study is to translate previous work to human scale and clinically relevant cells, for the bioengineering of functional myocardial tissue based on the combination of human cardiac matrix and human iPS-derived cardiac myocytes. Methods and Results To provide a clinically relevant tissue scaffold, we translated perfusion-decellularization to human scale and obtained biocompatible human acellular cardiac scaffolds with preserved extracellular matrix composition, architecture, and perfusable coronary vasculature. We then repopulated this native human cardiac matrix with cardiac myocytes derived from non-transgenic human induced pluripotent stem cells (iPSCs) and generated tissues of increasing three-dimensional complexity. We maintained such cardiac tissue constructs in culture for 120 days to demonstrate definitive sarcomeric structure, cell and matrix deformation, contractile force, and electrical conduction. To show that functional myocardial tissue of human scale can be built on this platform, we then partially recellularized human whole heart scaffolds with human iPSC-derived cardiac myocytes. Under biomimetic culture, the seeded constructs developed force-generating human myocardial tissue, showed electrical conductivity, left ventricular pressure development, and metabolic function. Conclusions Native cardiac extracellular matrix scaffolds maintain matrix components and structure to support the seeding and engraftment of human iPS-derived cardiac myocytes, and enable

  19. Duality symmetries and G+++ theories

    NASA Astrophysics Data System (ADS)

    Riccioni, Fabio; Steele, Duncan; West, Peter

    2008-02-01

    We show that the nonlinear realizations of all the very extended algebras G+++, except the B and C series which we do not consider, contain fields corresponding to all possible duality symmetries of the on-shell degrees of freedom of these theories. This result also holds for G+++2 and we argue that the nonlinear realization of this algebra accounts precisely for the form fields present in the corresponding supersymmetric theory. We also find a simple necessary condition for the roots to belong to a G+++ algebra.

  20. Effects of matrix heterogeneity on animal dispersal: from individual behavior to metapopulation-level parameters.

    PubMed

    Revilla, Eloy; Wiegand, Thorsten; Palomares, Francisco; Ferreras, Pablo; Delibes, Miguel

    2004-11-01

    Mounting theoretical and empirical evidence shows that matrix heterogeneity may have contrasting effects on metapopulation dynamics by contributing to patch isolation in nontrivial ways. We analyze the movement properties during interpatch dispersal in a metapopulation of Iberian lynx (Lynx pardinus). On a daily temporal scale, lynx habitat selection defines two types of matrix habitats where individuals may move: open and dispersal habitats (avoided and used as available, respectively). There was a strong and complex impact of matrix heterogeneity on movement properties at several temporal scales (hourly and daily radiolocations and the entire dispersal event). We use the movement properties on the hourly temporal scale to build a simulation model to reconstruct individual dispersal events. The two most important parameters affecting model predictions at both the individual (daily) and metapopulation scales were related to the movement capacity (number of movement steps per day and autocorrelation in dispersal habitat) followed by the parameters representing the habitat selection in the matrix. The model adequately reproduced field estimates of population-level parameters (e.g., interpatch connectivity, maximum and final dispersal distances), and its performance was clearly improved when including the effect of matrix heterogeneity on movement properties. To assume there is a homogeneous matrix results in large errors in the estimate of interpatch connectivity, especially for close patches separated by open habitat or corridors of dispersal habitat, showing how important it is to consider matrix heterogeneity when it is present. Movement properties affect the interaction of dispersing individuals with the landscape and can be used as a mechanistic representation of dispersal at the metapopulation level. This is so when the effect of matrix heterogeneity on movement properties is evaluated under biologically meaningful spatial and temporal scales.

  1. Generating Nice Linear Systems for Matrix Gaussian Elimination

    ERIC Educational Resources Information Center

    Homewood, L. James

    2004-01-01

    In this article an augmented matrix that represents a system of linear equations is called nice if a sequence of elementary row operations that reduces the matrix to row-echelon form, through matrix Gaussian elimination, does so by restricting all entries to integers in every step. Many instructors wish to use the example of matrix Gaussian…

  2. 48 CFR 1652.370 - Use of the matrix.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Use of the matrix. 1652.370... HEALTH BENEFITS ACQUISITION REGULATION CLAUSES AND FORMS CONTRACT CLAUSES FEHBP Clause Matrix 1652.370 Use of the matrix. (a) The matrix in this section lists the FAR and FEHBAR clauses to be used...

  3. Generalized Mueller matrix method for polarization mode dispersion measurement in a system with polarization-dependent loss or gain.

    PubMed

    Dong, H; Shum, P; Yan, M; Zhou, J Q; Ning, G X; Gong, Y D; Wu, C Q

    2006-06-12

    A generalized Mueller matrix method (GMMM) is proposed to measure the polarization mode dispersion (PMD) in an optical fiber system with polarization-dependent loss or gain (PDL/G). This algorithm is based on the polar decomposition of a 4X4 matrix which corresponds to a Lorentz transformation. Compared to the generalized Poincaré sphere method, the GMMM can measure PMD accurately with a relatively larger frequency step, and the obtained PMD data has very low noise level.

  4. HXeOBr in a xenon matrix

    SciTech Connect

    Khriachtchev, Leonid; Tapio, Salla; Domanskaya, Alexandra V.; Raesaenen, Markku; Isokoski, Karoliina; Lundell, Jan

    2011-03-28

    We report on a new noble-gas molecule HXeOBr prepared in a low-temperature xenon matrix from the HBr and N{sub 2}O precursors by UV photolysis and thermal annealing. This molecule is assigned with the help of deuteration experiments and ab initio calculations including anharmonic methods. The H-Xe stretching frequency of HXeOBr is observed at 1634 cm{sup -1}, which is larger by 56 cm{sup -1} than the frequency of HXeOH identified previously. The experiments show a higher thermal stability of HXeOBr molecules in a xenon matrix compared to HXeOH.

  5. Analytical solutions to matrix diffusion problems

    SciTech Connect

    Kekäläinen, Pekka

    2014-10-06

    We report an analytical method to solve in a few cases of practical interest the equations which have traditionally been proposed for the matrix diffusion problem. In matrix diffusion, elements dissolved in ground water can penetrate the porous rock surronuding the advective flow paths. In the context of radioactive waste repositories this phenomenon provides a mechanism by which the area of rock surface in contact with advecting elements is greatly enhanced, and can thus be an important delay mechanism. The cases solved are relevant for laboratory as well for in situ experiments. Solutions are given as integral representations well suited for easy numerical solution.

  6. Ceramic Matrix Composite (CMC) Materials Development

    NASA Technical Reports Server (NTRS)

    DiCarlo, James

    2001-01-01

    Under the former NASA EPM Program, much initial progress was made in identifying constituent materials and processes for SiC/SiC ceramic composite hot-section components. This presentation discusses the performance benefits of these approaches and elaborates on further constituent and property improvements made under NASA UEET. These include specific treatments at NASA that significantly improve the creep and environmental resistance of the Sylramic(TM) Sic fiber as well as the thermal conductivity and creep resistance of the CVI Sic matrix. Also discussed are recent findings concerning the beneficial effects of certain 2D-fabric architectures and carbon between the BN interphase coating and Sic matrix.

  7. Ceramic Matrix Composite (CMC) Materials Characterization

    NASA Technical Reports Server (NTRS)

    Calomino, Anthony

    2001-01-01

    Under the former NASA EPM Program, much initial progress was made in identifying constituent materials and processes for SiC/SiC ceramic composite hot-section components. This presentation discusses the performance benefits of these approaches and elaborates on further constituent and property improvements made under NASA UEET. These include specific treatments at NASA that significantly improve the creep and environmental resistance of the Sylramic(TM) SiC fiber as well as the thermal conductivity and creep resistance of the CVI Sic matrix. Also discussed are recent findings concerning the beneficial effects of certain 2D-fabric architectures and carbon between the BN interphase coating and Sic matrix.

  8. Universality in complex networks: random matrix analysis.

    PubMed

    Bandyopadhyay, Jayendra N; Jalan, Sarika

    2007-08-01

    We apply random matrix theory to complex networks. We show that nearest neighbor spacing distribution of the eigenvalues of the adjacency matrices of various model networks, namely scale-free, small-world, and random networks follow universal Gaussian orthogonal ensemble statistics of random matrix theory. Second, we show an analogy between the onset of small-world behavior, quantified by the structural properties of networks, and the transition from Poisson to Gaussian orthogonal ensemble statistics, quantified by Brody parameter characterizing a spectral property. We also present our analysis for a protein-protein interaction network in budding yeast.

  9. Some remarks on unilateral matrix equations

    SciTech Connect

    Cerchiai, Bianca L.; Zumino, Bruno

    2001-02-01

    We briefly review the results of our paper LBNL-46775: We study certain solutions of left-unilateral matrix equations. These are algebraic equations where the coefficients and the unknown are square matrices of the same order, or, more abstractly, elements of an associative, but possibly noncommutative algebra, and all coefficients are on the left. Recently such equations have appeared in a discussion of generalized Born-Infeld theories. In particular, two equations, their perturbative solutions and the relation between them are studied, applying a unified approach based on the generalized Bezout theorem for matrix polynomials.

  10. Interaction picture density matrix quantum Monte Carlo

    SciTech Connect

    Malone, Fionn D. Lee, D. K. K.; Foulkes, W. M. C.; Blunt, N. S.; Shepherd, James J.; Spencer, J. S.

    2015-07-28

    The recently developed density matrix quantum Monte Carlo (DMQMC) algorithm stochastically samples the N-body thermal density matrix and hence provides access to exact properties of many-particle quantum systems at arbitrary temperatures. We demonstrate that moving to the interaction picture provides substantial benefits when applying DMQMC to interacting fermions. In this first study, we focus on a system of much recent interest: the uniform electron gas in the warm dense regime. The basis set incompleteness error at finite temperature is investigated and extrapolated via a simple Monte Carlo sampling procedure. Finally, we provide benchmark calculations for a four-electron system, comparing our results to previous work where possible.

  11. New components of the Golgi matrix

    PubMed Central

    Xiang, Yi; Wang, Yanzhuang

    2012-01-01

    The eukaryotic Golgi apparatus is characterized by a stack of flattened cisternae that are surrounded by transport vesicles. The organization and function of the Golgi require Golgi matrix proteins, including GRASPs and golgins, which exist primarily as fiber-like bridges between Golgi cisternae or between cisternae and vesicles. In this review, we highlight recent findings on Golgi matrix proteins, including their roles in maintaining the Golgi structure, vesicle tethering, and novel, unexpected functions. These new discoveries further our understanding of the molecular mechanisms that maintain the structure and the function of the Golgi, as well as its relationship with other cellular organelles such as the centrosome. PMID:21494806

  12. Research on graphite reinforced glass matrix composites

    NASA Technical Reports Server (NTRS)

    Bacon, J. F.; Prewo, K. M.

    1977-01-01

    The results of research for the origination of graphite-fiber reinforced glass matrix composites are presented. The method selected to form the composites consisted of pulling the graphite fiber through a slurry containing powdered glass, winding up the graphite fiber and the glass it picks up on a drum, drying, cutting into segments, loading the tape segment into a graphite die, and hot pressing. During the course of the work, composites were made with a variety of graphite fibers in a glass matrix.

  13. Polymeric matrix materials for infrared metamaterials

    SciTech Connect

    Dirk, Shawn M; Rasberry, Roger D; Rahimian, Kamyar

    2014-04-22

    A polymeric matrix material exhibits low loss at optical frequencies and facilitates the fabrication of all-dielectric metamaterials. The low-loss polymeric matrix material can be synthesized by providing an unsaturated polymer, comprising double or triple bonds; partially hydrogenating the unsaturated polymer; depositing a film of the partially hydrogenated polymer and a crosslinker on a substrate; and photopatterning the film by exposing the film to ultraviolet light through a patterning mask, thereby cross-linking at least some of the remaining unsaturated groups of the partially hydrogenated polymer in the exposed portions.

  14. Conducted Emission Evaluation for Direct Matrix Converters

    NASA Astrophysics Data System (ADS)

    Nothofer, A.; Tarisciotti, L.; Greedy, S.; Empringham, L.; De Lillo, L.; Degano, M.

    2016-05-01

    Matrix converters have been recently proposed as an alternative solution to the standard back-to-back converter in aerospace applications. However, Electromagnetic Interference (EMI), in particular, conducted emissions represent a critical aspect for this converter family. Direct Matrix Converter (DMC) are usually modelled only at the normal operating frequency, but for the research presented in this paper, the model is modified in order to include a detailed high frequency description, which is of interest for conducted emission studies.This paper analyzes the performance of DMC, when different control and modulation techniques are used. Experimental results are shown to validate the simulation models.

  15. Chaos in the BMN matrix model

    NASA Astrophysics Data System (ADS)

    Asano, Yuhma; Kawai, Daisuke; Yoshida, Kentaroh

    2015-06-01

    We study classical chaotic motions in the Berenstein-Maldacena-Nastase (BMN) matrix model. For this purpose, it is convenient to focus upon a reduced system composed of two-coupled anharmonic oscillators by supposing an ansatz. We examine three ansätze: 1) two pulsating fuzzy spheres, 2) a single Coulomb-type potential, and 3) integrable fuzzy spheres. For the first two cases, we show the existence of chaos by computing Poincaré sections and a Lyapunov spectrum. The third case leads to an integrable system. As a result, the BMN matrix model is not integrable in the sense of Liouville, though there may be some integrable subsectors.

  16. Postglacial matrix diffusion in a boulder sample

    SciTech Connect

    Rasilainen, K.; Suksi, J.; Kulmala, S.; Hellmuth, K.H.; Lindberg, A.

    1996-08-01

    A boulder sample was studied for its unusual U content. Analyses of U-series nuclides within the rock matrix perpendicular to an assumed fracture face show abrupt pulse-like concentration distributions with very low concentrations of U daughters. Both Th-230/U-234 and Pa-231/U-235 activity ratios are low, indicating recent U accumulation into the rock. Matrix diffusion is tested as a possible cause for the experimental observations. The authors assume that the diffusion process was triggered and controlled by rock expansion, strong mixing of different water types and rapid land uplift at the end phase of the last glaciation.

  17. Polymer Matrix Composites for Propulsion Systems

    NASA Technical Reports Server (NTRS)

    Nettles, Alan T.

    2003-01-01

    The Access-to-Space study identified the requirement for lightweight structures to achieve orbit with a single-stage vehicle. Thus a task was undertaken to examine the use of polymer matrix composites for propulsion components. It was determined that the effort of this task would be to extend previous efforts with polymer matrix composite feedlines and demonstrate the feasibility of manufacturing large diameter feedlines with a complex shape and integral flanges, (i.e. all one piece with a 90 deg bend), and assess their performance under a cryogenic atmosphere.

  18. Novel formulations of CKM matrix renormalization

    SciTech Connect

    Kniehl, Bernd A.; Sirlin, Alberto

    2009-12-17

    We review two recently proposed on-shell schemes for the renormalization of the Cabibbo-Kobayashi-Maskawa (CKM) quark mixing matrix in the Standard Model. One first constructs gauge-independent mass counterterm matrices for the up- and down-type quarks complying with the hermiticity of the complete mass matrices. Diagonalization of the latter then leads to explicit expressions for the CKM counterterm matrix, which are gauge independent, preserve unitarity, and lead to renormalized amplitudes that are non-singular in the limit in which any two quarks become mass degenerate. One of the schemes also automatically satisfies flavor democracy.

  19. Matrix metalloproteinases in plants: a brief overview.

    PubMed

    Marino, Giada; Funk, Christiane

    2012-05-01

    Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases belonging to the metzincin clan. MMPs have been characterized in detail in mammals, and they have been shown to play key roles in many physiological and pathological processes. Plant MMP-like proteases exist, but relatively few have been characterized. It has been speculated that plant MMPs are involved in remodeling of the plant extracellular matrix during growth, development and stress response. However, the precise functions and physiological substrates in higher plants remain to be determined. In this brief overview, we summarize the current knowledge of MMPs in higher plants and algae.

  20. Hybrid Ceramic Matrix Fibrous Composites: an Overview

    NASA Astrophysics Data System (ADS)

    Naslain, R.

    2011-10-01

    Ceramic-Matrix Composites (CMCs) consist of a ceramic fiber architecture in a ceramic matrix, bonded together through a thin interphase. The present contribution is limited to non-oxide CMCs. Their constituents being oxidation-prone, they are protected by external coatings. We state here that CMCs display a hybrid feature, when at least one of their components is not homogeneous from a chemical or microstructural standpoint. Hybrid fiber architectures are used to tailor the mechanical or thermal CMC-properties whereas hybrid interphases, matrices and coatings to improve CMC resistance to aggressive environments.

  1. Connective stability of nonlinear matrix systems

    NASA Technical Reports Server (NTRS)

    Siljak, D. D.

    1974-01-01

    Consideration of stability under structural perturbations of free dynamic systems described by the differential equation dx/dt = A(t,x)x, where the matrix A(t,x) has time-varying nonlinear elements. The concept of 'connective stability' is introduced to study the structural properties of competitive-cooperative nonlinear matrix systems. It is shown that stability reliability in such systems is high and that they remain stable despite time-varying (including 'on-off') interaction among individual agents present in the system. The results obtained can be used to study stability aspects of mathematical models arising in as diverse fields as economics, biology, arms races, and transistor circuits.

  2. Differential matrix formalism for depolarizing anisotropic media.

    PubMed

    Ossikovski, Razvigor

    2011-06-15

    Azzam's differential matrix formalism [J. Opt. Soc. Am. 68, 1756 (1978)], originally developed for longitudinally inhomogeneous anisotropic nondepolarizing media, is extended to include depolarizing media. The generalization is physically interpreted in terms of means and uncertainties of the elementary optical properties of the medium, as well as of three anisotropy absorption parameters introduced to describe the depolarization. The formalism results in a particularly simple mathematical procedure for the retrieval of the elementary properties of a generally depolarizing anisotropic medium, assumed to be globally homogeneous, from its experimental Mueller matrix. The approach is illustrated on literature data and the conditions of its validity are identified and discussed.

  3. G2 Gas Cloud Simulation

    NASA Video Gallery

    This simulation shows the future behavior of the G2 gas cloud now approaching Sgr A*, the supermassive black hole at the center of the Milky Way. X-ray emission from the cloud's tidal interaction w...

  4. G6PD: The Test

    MedlinePlus

    ... initial findings. Screening tests typically involve a simple qualitative test that only tells if the person has ... this testing is used almost exclusively in the research setting. G6PD testing should not be done soon ...

  5. Iontophoresis across the proximal nail fold to target drugs to the nail matrix.

    PubMed

    Manda, Prashanth; Sammeta, Srinivasa M; Repka, Michael A; Murthy, S Narasimha

    2012-07-01

    The main objective of the present study was to investigate the plausibility of iontophoretic delivery of drugs to the nail matrix via proximal nail fold. The in vitro drug transport studies were performed in Franz diffusion cells across folded epidermis, which is used as a model for the proximal nail fold. The amount of drug transported into the receiver compartment following iontophoresis for 3 h at 0.5 mA/cm(2) was 150-fold higher than the control (0.008 ± 0.002 μg/cm(2)). The amount of drug present in the skin after iontophoresis (0.45 ± 0.12 μg/mg) was approximately fivefold higher as compared with that of the control (0.08 ± 0.01 μg/mg). Iontophoresis of terbinafine across the proximal nail fold was assessed using excised cadaver toe model as well. A custom-designed foam-pad-type patch system was used for iontophoresis in cadaver toes. The amount of the drug delivered into the nail matrix following iontophoresis for 3 h was significantly higher than the minimum inhibition concentration of terbinafine. However, on the contrary, passive delivery for about 24 h did not result in any detectable drug levels in the nail matrix. Iontophoresis across the proximal nail fold could be developed as a potential method to target drugs to nail matrix.

  6. Effect of matrix elasticity on the continuous foaming of food models.

    PubMed

    Narchi, I; Vial, Ch; Djelveh, G

    2008-12-01

    The aim is to understand the effect of matrix elasticity on continuous foaming using food models based on glucose syrup. This was modified by adding polyacrylamide (PAA) with 2% whey protein isolate (WPI) or Tween 80 as foaming agents. Foaming was conducted in a stirred column. Rotation speed N and gas-to-liquid flow ratio (G/L) were varied. Overrun, average bubble size d (32), texture and stability were measured using densimetry, image analysis, and rheometry, respectively. Experimental results showed that 0.01% PAA did not modify the viscosity of 2% WPI models, but conferred low elastic behavior. PAA (0.05%) doubled matrix viscosity and drastically increased elasticity. The increase of elasticity became slower for further PAA addition. Foaming experiments demonstrated that theoretical overrun could not be achieved for inelastic WPI models in two cases: for high viscosity and low N, as dispersion effectiveness was reduced; for high G/L and N because of enhanced coalescence. Matrix elasticity was shown to increase overrun at constant viscosity for high G/L by enhancing interface stabilization. However, in elastic models, gas dispersion was more difficult and d (32) was higher than in inelastic fluids of similar viscosity. Finally, when the limiting step was dispersion, foaming was shown to be negatively affected by matrix elasticity.

  7. On-matrix derivatization for dynamic headspace sampling of nonvolatile surface residues.

    PubMed

    Harvey, Scott D; Wahl, Jon H

    2012-09-21

    The goal of this study is to extend sampling by the field and laboratory emission cell (FLEC) dynamic headspace technique to applications that target nonvolatile residues. On-matrix derivatization of residues to render analytes stable and more volatile is explored to achieve this goal. Results show that on-matrix derivatizations of nerve agent hydrolysis products (monoalkyl methylphosphonic acids and methylphosphonic acid [MPA]) with diazomethane were successful on glass and painted wallboard (at the 10-μg level). It also was successful on the more difficult concrete (at the 500-μg level) and carpet (at the 20-μg level), substrates that cannot be successfully sampled using swipe techniques. Analysis of additional chemical warfare (CW)-associated residues can be approached by on-matrix derivatization with trifluoroacetic anhydride (TFAA). For example, amines (used as stabilizers or present as decomposition products of the nerve agent VX) or thiodiglycol (hydrolysis product of sulfur mustard) could be sampled as their TFAA derivatives from glass, painted wallboard, and concrete (at the 40-μg level), as well as carpet (at the 80-μg level) surfaces. Although the amine and thiodiglycol are semi-volatile and could be sampled directly, derivatization improves the recovery and chromatographic behavior of these analytes.

  8. Women’s G Tolerance

    DTIC Science & Technology

    1986-08-01

    for the groups matched by age (70 pairs), weight sickness, uncomfortable feelings of distension in arms (26 pairs), and act~vity status (84 pairs...mass-spring-damper) s ,stem Straining G tolerance, being dpendent on skeletal having a resonant frequency above about I Hz. As muscular strength and...of the women’s G tolerance stud\\ scclic variations in muscular strength and endurance. was below 0.1 Hz (11), the production of any significant

  9. Motion Control for Nonholonomic Systems on Matrix Lie Groups

    DTIC Science & Technology

    1998-01-01

    representations of systems on a certain nilpotent matrix group. After studying the technique of nilpotentization in the setting of systems on matrix ...the technique of nilpotentization in the setting of systems on matrix Lie groups we show how motion control laws derived for nilpotent systems can be...of systems on a certain nilpotent matrix group. After studying the technique of nilpotentization in the setting of systems on matrix Lie groups we show

  10. Uniqueness of the differential Mueller matrix of uniform homogeneous media.

    PubMed

    Devlaminck, Vincent; Ossikovski, Razvigor

    2014-06-01

    We show that the differential matrix of a uniform homogeneous medium containing birefringence may not be uniquely determined from its Mueller matrix, resulting in the potential existence of an infinite set of elementary polarization properties parameterized by an integer parameter. The uniqueness depends on the symmetry properties of a special differential matrix derived from the eigenvalue decomposition of the Mueller matrix. The conditions for the uniqueness of the differential matrix are identified, physically discussed, and illustrated in examples from the literature.

  11. Combining biofilm matrix measurements with biomass and viability assays in susceptibility assessments of antimicrobials against Staphylococcus aureus biofilms.

    PubMed

    Skogman, Malena Elise; Vuorela, Pia Maarit; Fallarero, Adyary

    2012-09-01

    Despite that three types of assays (measuring biofilm viability, biomass, or matrix) are described to assess anti-biofilm activity, they are rarely used together. As infections can easily reappear if the matrix is not affected after antibiotic treatments, our goal was to explore the simultaneous effects of antibiotics on the viability, biomass and matrix of Staphylococcus aureus biofilms (ATCC 25923). Viability and biomass were quantified using resazurin and crystal violet staining sequentially in the same plate, while matrix staining was conducted with a wheat germ agglutinin-Alexa Fluor 488 fluorescent conjugate. Establishment of the detection limits and linearity ranges allowed concluding that all three methods were able to estimate biofilm formation in a similar fashion. In a susceptibility study with 18-h biofilms, two model compounds (penicillin G and ciprofloxacin) caused a reduction on the viability and biomass accompanied by an increase or not changed levels of the matrix, respectively. This response pattern was also proven for S. aureus Newman, S. epidermidis and E. coli biofilms. A classification of antibiotics based on five categories according to their effects on viability and matrix has been proposed earlier. Our data suggests a sixth group, represented by penicillin, causing decrease in bacterial viability but showing stimulatory effects on the matrix. Further, if effects on the matrix are not taken into account, the long-term chemotherapeutic effect of antibiotics can be jeopardized in spite of the positive effects on biofilms viability and biomass. Thus, measuring all these three endpoints simultaneously provide a more complete and accurate picture.

  12. Heterogeneous expression of HLA-G1, -G2, -G5, -G6, and -G7 in myeloid and plasmacytoid dendritic cells isolated from umbilical cord blood.

    PubMed

    Román, Angela; Rodríguez, Miriam; Herraiz, Miguel A; Jordá, Julia; Cervera, Isabel; Peñaloza, Jorge; Vidart, Jose A; Martinez-Laso, Jorge

    2009-02-01

    Human leukocyte antigen (HLA)-G is a human nonclassic major histocompatibility complex (MHC) molecule characterized by a limited polymorphism and a low, restricted cell surface expression. HLA-G is constitutively expressed on trophoblasts, fetal endothelial, and epithelial cells, conferring alloimmune protection during pregnancy. HLA-G is also expressed in some malignancies and on macrophages and dendritic cells (DC) in tumoral and inflammatory diseases. Because DC constitute an important component in the immune response and umbilical cord blood has a different immune behavior than peripheral blood, the HLA-G protein profile and mRNA expression were investigated on the different DC subsets present in cord blood. Surface and intracellular expression have been reported on DC and HLA-G1, -G2, -G5, -G6, and -G7 transcripts were present. Different levels of soluble HLA-G were obtained from serum and correlated with gene expression. These data are in contrast with the data previously described for adult peripheral blood, where a limited pattern of HLA-G transcripts was reported; only in the maturation process were more isoforms present. These results demonstrate that DC from cord blood have a different behavior than DC in peripheral blood and could be in accordance with the results obtained in cord blood transplantation, where a lesser effect of graft-versus-host disease exists than in bone marrow transplantation.

  13. The Transition Matrix in Flat-histogram Sampling

    NASA Astrophysics Data System (ADS)

    Brown, Gregory; Eisenbach, M.; Li, Y. W.; Stocks, G. M.; Nicholson, D. M.; Odbadrakh, Kh.; Rikvold, P. A.

    2015-03-01

    Calculating the thermodynamic density of states (DOS) via flat-histogram sampling is a powerful numerical method for characterizing the temperature-dependent properties of materials. Since the calculated DOS is refined directly from the statistics of the sampling, methods of accelerating the sampling, e.g. through windowing and slow forcing, skew the resulting DOS. Calculating the infinite-temperature transition matrix during the flat-histogram sampling decouples the sampling from estimating the DOS, and allows the techniques of Transition Matrix Monte Carlo to be applied. This enables the calculation of the properties for very large system sizes and thus finite-size scaling analysis of the specific heat, magnetic susceptibility, and cumulant crossings at critical points. We discuss these developments in the context of models for magnetocaloric and spin-crossover materials. This work was performed at the Oak Ridge National Laboratory, which is managed by UT-Battelle for the U.S. Department of Energy. It was sponsored by the U.S. Department of Energy, Office of Basic Energy Sciences, Office of Advanced Scientific Computing Research, and the Oak Ridge Leadership Computing Facility. PAR is supported by the National Science Foundation.

  14. The regulation of matrix metalloproteinases and their inhibitors.

    PubMed

    Clark, Ian M; Swingler, Tracey E; Sampieri, Clara L; Edwards, Dylan R

    2008-01-01

    The matrix metalloproteinases (MMP) are a family of 23 enzymes in man. These enzymes were originally described as cleaving extracellular matrix (ECM) substrates with a predominant role in ECM homeostasis, but it is now clear that they have much wider functionality. Control over MMP and/or tissue inhibitor of metalloproteinases (TIMP) activity in vivo occurs at different levels and involves factors such as regulation of gene expression, activation of zymogens and inhibition of active enzymes by specific inhibitors. Whilst these enzymes and inhibitors have clear roles in physiological tissue turnover and homeostasis, if control of their expression or activity is lost, they contribute to a number of pathologies including e.g. cancer, arthritis and cardiovascular disease. The expression of many MMPs and TIMPs is regulated at the level of transcription by a variety of growth factors, cytokines and chemokines, though post-transcriptional pathways may contribute to this regulation in specific cases. The contribution of epigenetic modifications has also been uncovered in recent years. The promoter regions of many of these genes have been, at least partly, characterised including the role of identified single nucleotide polymorphisms. This article aims to review current knowledge across these gene families and use a bioinformatic approach to fill the gaps where no functional data are available.

  15. Development and application of a density dependent matrix ...

    EPA Pesticide Factsheets

    Ranging along the Atlantic coast from US Florida to the Maritime Provinces of Canada, the Atlantic killifish (Fundulus heteroclitus) is an important and well-studied model organism for understanding the effects of pollutants and other stressors in estuarine and marine ecosystems. Matrix population models are useful tools for ecological risk assessment because they integrate effects across the life cycle, provide a linkage between endpoints observed in the individual and ecological risk to the population as a whole, and project outcomes for many generations in the future. We developed a density dependent matrix population model for Atlantic killifish by modifying a model developed for fathead minnow (Pimephales promelas) that has proved to be extremely useful, e.g. to incorporate data from laboratory studies and project effects of endocrine disrupting chemicals. We developed a size-structured model (as opposed to one that is based upon developmental stages or age class structure) so that we could readily incorporate output from a Dynamic Energy Budget (DEB) model, currently under development. Due to a lack of sufficient data to accurately define killifish responses to density dependence, we tested a number of scenarios realistic for other fish species in order to demonstrate the outcome of including this ecologically important factor. We applied the model using published data for killifish exposed to dioxin-like compounds, and compared our results to those using

  16. Matrix isolation apparatus with extended sample collection capability

    DOEpatents

    Reedy, Gerald T.

    1987-01-01

    A gas-sample collection device provides for the matrix isolation of increased amounts of a sample material for spectrographic analysis from a gas chromatographic separation. The device includes an evacuated sample collection chamber containing a disc-like specular carousel having a generally circular lateral surface upon which the sample is deposited in an inert gas matrix for infrared (IR) spectral analysis. The evacuated sample chamber is mounted in a fixed manner and is coupled to and supports a rotating cryostatic coupler which, in turn, supports the specular carousel within the collection chamber. A rotational drive system connected to the cryostatic coupler provides for its rotational displacement as well as that of the sample collecting carousel. In addition, rotation of the cryostatic coupler effects vertical displacement of the carousel to permit the collection of an extended sample band in a helical configuration on the entire lateral surface of the carousel. The various components of the carousel's angular/linear displacement drive system are located exterior to the cryostatic coupler for easy access and improved operation. The cryostatic coupler includes a 360.degree. rotary union assembly for permitting the delivery of a high pressure working fluid to the cryostatic coupler in a continuous flow manner for maintaining the specular carousel at a low temperature, e.g., 10.degree.-20.degree. K., for improved uninterrupted gas sample collection and analysis.

  17. Immunoglobulin G4 (IgG4)-Related Hypophysitis.

    PubMed

    Rotondo, Fabio; Qaddoura, Amro; Syro, Luis V; Karamchandani, Jason; Munoz, David G; Arroyave, Mariam J; Ospina, William P; Cusimano, Michael D; Kovacs, Kalman

    2017-01-13

    We report two different cases of IgG4-related hypophysitis. In the first case, a pituitary lesion was accompanied by lymphocytic meningitis possibly mimicking tuberculous meningitis. The second case was unassociated with involvement of other organs. No histologic differences were noted between the two cases indicating that the morphologic features of the hypophysial lesion do not depend on the presence of other lesions. The pathogenesis of IgG4 hypophysitis is not known, and further study is necessary to explore the cause, progression, and influencing factors of this disease.

  18. Matrix Recipes for Hard Thresholding Methods

    DTIC Science & Technology

    2012-11-07

    present below some characteristic examples for the linear operator A: Matrix Completion (MC): As a motivating example, consider the famous Netflix ...basis independent models from point queries via low-rank methods. Technical report, EPFL, 2012. [8] J. Bennett and S. Lanning. The netflix prize. In In

  19. TAUBERIAN THEOREMS FOR MATRIX REGULAR VARIATION

    PubMed Central

    MEERSCHAERT, M. M.; SCHEFFLER, H.-P.

    2013-01-01

    Karamata’s Tauberian theorem relates the asymptotics of a nondecreasing right-continuous function to that of its Laplace-Stieltjes transform, using regular variation. This paper establishes the analogous Tauberian theorem for matrix-valued functions. Some applications to time series analysis are indicated. PMID:24644367

  20. The Curriculum Matrix: Transcendence and Mathematics.

    ERIC Educational Resources Information Center

    Foshay, Arthur W.

    1991-01-01

    Describes a curriculum matrix embodying three elements (purpose, substance, practice) and their various dimensions. Argues for a transcendent view of mathematics as a profoundly human, spiritual, astonishing, majestic, and powerful enterprise. Outlines seven mathematical ideas that have transformed human experience by celebrating unlimited freedom…

  1. Matrix vesicles: Are they anchored exosomes?

    PubMed

    Shapiro, Irving M; Landis, William J; Risbud, Makarand V

    2015-10-01

    Numerous studies have documented that matrix vesicles are unique extracellular membrane-bound microparticles that serve as initial sites for mineral formation in the growth plate and most other vertebrate mineralizing tissues. Microparticle generation is not confined to hard tissues, as cells in soft tissues generate similar structures; numerous studies have shown that a common type of extracellular particle, termed an exosome, a product of the endosomal pathway, shares many characteristics of matrix vesicles. Indeed, analyses of size, morphology and lipid and protein content indicate that matrix vesicles and exosomes are homologous structures. Such a possibility impacts our understanding of the biogenesis, processing and function of matrix vesicles (exosomes) in vertebrate hard tissues and explains in part how cells control the earliest stages of mineral deposition. Moreover, since exosomes influence a spectrum of functions, including cell-cell communication, it is suggested that this type of microparticle may provide a mechanism for the transfer of signaling molecules between cells within the growth plate and thereby regulate endochondral bone development and formation.

  2. Derive Workshop Matrix Algebra and Linear Algebra.

    ERIC Educational Resources Information Center

    Townsley Kulich, Lisa; Victor, Barbara

    This document presents the course content for a workshop that integrates the use of the computer algebra system Derive with topics in matrix and linear algebra. The first section is a guide to using Derive that provides information on how to write algebraic expressions, make graphs, save files, edit, define functions, differentiate expressions,…

  3. Emerging Educational Institutional Decision-Making Matrix

    ERIC Educational Resources Information Center

    Ashford-Rowe, Kevin H.; Holt, Marnie

    2011-01-01

    The "emerging educational institutional decision-making matrix" is developed to allow educational institutions to adopt a rigorous and consistent methodology of determining which of the myriad of emerging educational technologies will be the most compelling for the institution, particularly ensuring that it is the educational or pedagogical but…

  4. Non-Hermitian Euclidean random matrix theory.

    PubMed

    Goetschy, A; Skipetrov, S E

    2011-07-01

    We develop a theory for the eigenvalue density of arbitrary non-Hermitian Euclidean matrices. Closed equations for the resolvent and the eigenvector correlator are derived. The theory is applied to the random Green's matrix relevant to wave propagation in an ensemble of pointlike scattering centers. This opens a new perspective in the study of wave diffusion, Anderson localization, and random lasing.

  5. Inverter Matrix for the Clementine Mission

    NASA Technical Reports Server (NTRS)

    Buehler, M. G.; Blaes, B. R.; Tardio, G.; Soli, G. A.

    1994-01-01

    An inverter matrix test circuit was designed for the Clementine space mission and is built into the RRELAX (Radiation and Reliability Assurance Experiment). The objective is to develop a circuit that will allow the evaluation of the CMOS FETs using a lean data set in the noisy spacecraft environment.

  6. Mueller matrix imaging ellipsometry for nanostructure metrology.

    PubMed

    Liu, Shiyuan; Du, Weichao; Chen, Xiuguo; Jiang, Hao; Zhang, Chuanwei

    2015-06-29

    In order to achieve effective process control, fast, inexpensive, nondestructive and reliable nanometer scale feature measurements are extremely useful in high-volume nanomanufacturing. Among the possible techniques, optical scatterometry is relatively ideal due to its high throughput, low cost, and minimal sample damage. However, this technique is inherently limited by the illumination spot size of the instrument and the low efficiency in construction of a map of the sample over a wide area. Aiming at these issues, we introduce conventional imaging techniques to optical scatterometry and combine them with Mueller matrix ellipsometry based scatterometry, which is expected to be a powerful tool for the measurement of nanostructures in future high-volume nanomanufacturing, and propose to apply Mueller matrix imaging ellipsometry (MMIE) for nanostructure metrology. Two kinds of nanostructures were measured using an in-house developed Mueller matrix imaging ellipsometer in this work. The experimental results demonstrate that we can achieve Mueller matrix measurement and analysis for nanostructures with pixel-sized illumination spots by using MMIE. We can also efficiently construct parameter maps of the nanostructures over a wide area with pixel-sized lateral resolution by performing parallel ellipsometric analysis for all the pixels of interest.

  7. Science Unlimited: Grades K-6 Competency Matrix.

    ERIC Educational Resources Information Center

    Pennsylvania State Dept. of Education, Harrisburg. Div. of Arts and Sciences.

    This competency matrix matches the primary and intermediate Science Unlimited lessons with the established competencies which appear in the Science Unlimited competency continuum. Primary lessons deal with: investigating dripping faucets; classification/sorting; smell; eyes; color; air; weather; observation and description; mystery boxes; change;…

  8. Critical state of sand matrix soils.

    PubMed

    Marto, Aminaton; Tan, Choy Soon; Makhtar, Ahmad Mahir; Kung Leong, Tiong

    2014-01-01

    The Critical State Soil Mechanic (CSSM) is a globally recognised framework while the critical states for sand and clay are both well established. Nevertheless, the development of the critical state of sand matrix soils is lacking. This paper discusses the development of critical state lines and corresponding critical state parameters for the investigated material, sand matrix soils using sand-kaolin mixtures. The output of this paper can be used as an interpretation framework for the research on liquefaction susceptibility of sand matrix soils in the future. The strain controlled triaxial test apparatus was used to provide the monotonic loading onto the reconstituted soil specimens. All tested soils were subjected to isotropic consolidation and sheared under undrained condition until critical state was ascertain. Based on the results of 32 test specimens, the critical state lines for eight different sand matrix soils were developed together with the corresponding values of critical state parameters, M, λ, and Γ. The range of the value of M, λ, and Γ is 0.803-0.998, 0.144-0.248, and 1.727-2.279, respectively. These values are comparable to the critical state parameters of river sand and kaolin clay. However, the relationship between fines percentages and these critical state parameters is too scattered to be correlated.

  9. Evaluation of the Matrix Project. Interchange 77.

    ERIC Educational Resources Information Center

    McIvor, Gill; Moodie, Kristina

    The Matrix Project is a program that has been established in central Scotland with the aim of reducing the risk of offending and anti-social behavior among vulnerable children. The project provides a range of services to children between eight and 11 years of age who are at risk in the local authority areas of Clackmannanshire, Falkirk and…

  10. Fracture toughness testing of polymer matrix composites

    NASA Technical Reports Server (NTRS)

    Grady, Joseph E.

    1992-01-01

    The experimental techniques and associated data analysis methods used to measure the resistance to interlaminar fracture, or 'fracture toughness', of polymer matrix composite materials are described. A review in the use of energy techniques to characterize fracture behavior in elastic solids is given. An overview is presented of the types of approaches employed in the design of delamination-resistant composite materials.

  11. Proving Program Termination With Matrix Weighted Digraphs

    NASA Technical Reports Server (NTRS)

    Dutle, Aaron

    2015-01-01

    Program termination analysis is an important task in logic and computer science. While determining if a program terminates is known to be undecidable in general, there has been a significant amount of attention given to finding sufficient and computationally practical conditions to prove termination. One such method takes a program and builds from it a matrix weighted digraph. These are directed graphs whose edges are labeled by square matrices with entries in {-1,0,1}, equipped with a nonstandard matrix multiplication. Certain properties of this digraph are known to imply the termination of the related program. In particular, termination of the program can be determined from the weights of the circuits in the digraph. In this talk, the motivation for addressing termination and how matrix weighted digraphs arise will be briefly discussed. The remainder of the talk will describe an efficient method for bounding the weights of a finite set of the circuits in a matrix weighted digraph, which allows termination of the related program to be deduced.

  12. The Bushido Matrix for Couple Communication

    ERIC Educational Resources Information Center

    Li, Chi-Sing; Lin, Yu-Fen; Ginsburg, Phil; Eckstein, Daniel

    2012-01-01

    The concept of Japanese Bushido and its seven virtues were introduced by the authors in this article for the practice and application of couple communication. The Bushido Matrix Worksheet (BMW) was created for enhancing couple's awareness and understanding of each other's values and experiences. An activity and a case study to demonstrate the use…

  13. High performance SMC matrix for structural applications

    NASA Astrophysics Data System (ADS)

    Salard, T.; Lortie, F.; Gérard, J. F.; Peyre, C.

    2016-07-01

    Mechanical properties of a common SMC (Sheet Molding Compound) matrix constituted of a vinylester resin and a Low-Profile Additive (LPA) were compared to those of vinylester modified with core-shell rubber (CSR) particles. Valuable properties are brought by CSR, especially high impact strength, high fracture toughness with little loss in stiffness, in spite of the presence of CSR agglomerates in blends.

  14. Matrix Encoding For Correction Of Errors

    NASA Technical Reports Server (NTRS)

    Dotson, Ronald S.

    1991-01-01

    Method of matrix encoding and associated decoding provides for correction of errors in digital data recorded on magnetic tape. Intended specifically for use with commercial control circuit board and associated software making it possible to use video cassette recorder as backup for hard-disk memory of personal computer.

  15. Light weight polymer matrix composite material

    NASA Technical Reports Server (NTRS)

    Bowles, Kenneth J. (Inventor); Lowell, Carl E. (Inventor)

    1991-01-01

    A graphite fiber reinforced polymer matrix is layed up, cured, and thermally aged at about 750.degree. F. in the presence of an inert gas. The heat treatment improves the structural integrity and alters the electrical conductivity of the materials. In the preferred embodiment PMR-15 polyimides and Celion-6000 graphite fibers are used.

  16. The MOON project and DBD matrix elements

    NASA Astrophysics Data System (ADS)

    Ejiri, H.

    2009-06-01

    This is a brief report on experimental studies of double beta decays (DBD) in Japan, the MOON project for spectroscopic studies of neutrino-less DBD (0vββ) and on experimental studies of DBD nuclear matrix elements. Experimental DBD studies in Japan were made by geochemical methods on 130Te, 128Te and 96Zr and by a series of ELEGANT(EL) counting methods, EL III on 76Ge, EL IV, V on 100Mo, 116Cd, and EL VI on 48Ca. Future counter experiments are MOON, CANDLES, XMASS and DCBA. The MOON project, which is based on EL V, aims at studies of the Majorana nature of the neutrino (v) and the v-mass spectrum by spectroscopic 0vββ experiments with the v-mass sensitivity of < mmv > = 100-30 meV. The MOON detector is a super ensemble of multi-layer modules, each being composed by PL scintillator plates and position-sensitive detector planes. DBD nuclear matrix elements have been studied experimentally by using charge exchange reactions. The 2-neutrino DBD matrix elements are expressed by successive single-β matrix elements through low-lying intermediate states.

  17. Enhanced Resource Descriptions Help Learning Matrix Users.

    ERIC Educational Resources Information Center

    Roempler, Kimberly S.

    2003-01-01

    Describes the Learning Matrix digital library which focuses on improving the preparation of math and science teachers by supporting faculty who teach introductory math and science courses in two- and four-year colleges. Suggests it is a valuable resource for school library media specialists to support new science and math teachers. (LRW)

  18. Probabilistic Modeling of Ceramic Matrix Composite Strength

    NASA Technical Reports Server (NTRS)

    Shan, Ashwin R.; Murthy, Pappu L. N.; Mital, Subodh K.; Bhatt, Ramakrishna T.

    1998-01-01

    Uncertainties associated with the primitive random variables such as manufacturing process (processing temperature, fiber volume ratio, void volume ratio), constituent properties (fiber, matrix and interface), and geometric parameters (ply thickness, interphase thickness) have been simulated to quantify the scatter in the first matrix cracking strength (FMCS) and the ultimate tensile strength of SCS-6/RBSN (SiC fiber (SCS-6) reinforced reaction-bonded silicon nitride composite) ceramic matrix composite laminate at room temperature. Cumulative probability distribution function for the FMCS and ultimate tensile strength at room temperature (RT) of (0)(sub 8), (0(sub 2)/90(sub 2), and (+/-45(sub 2))(sub S) laminates have been simulated and the sensitivity of primitive variables to the respective strengths have been quantified. Computationally predicted scatter of the strengths for a uniaxial laminate have been compared with those from limited experimental data. Also the experimental procedure used in the tests has been described briefly. Results show a very good agreement between the computational simulation and the experimental data. Dominating failure modes in (0)(sub 8), (0/90)(sub s) and (+/-45)(sub S) laminates have been identified. Results indicate that the first matrix cracking strength for the (0)(sub S), and (0/90)(sub S) laminates is sensitive to the thermal properties, modulus and strengths of both the fiber and matrix whereas the ultimate tensile strength is sensitive to the fiber strength and the fiber volume ratio. In the case of a (+/-45)(sub S), laminate, both the FMCS and the ultimate tensile strengths have a small scatter range and are sensitive to the fiber tensile strength as well as the fiber volume ratio.

  19. Determination of Matrix Diffusion Properties of Granite

    SciTech Connect

    Holtta, Pirkko; Siitari-Kauppi, Marja; Huittinen, Nina; Poteri, Antti

    2007-07-01

    Rock-core column experiments were introduced to estimate the diffusion and sorption properties of Kuru Grey granite used in block-scale experiments. The objective was to examine the processes causing retention in solute transport through rock fractures, especially matrix diffusion. The objective was also to estimate the importance of retention processes during transport in different scales and flow conditions. Rock-core columns were constructed from cores drilled into the fracture and were placed inside tubes to form flow channels in the 0.5 mm gap between the cores and the tube walls. Tracer experiments were performed using uranin, HTO, {sup 36}Cl, {sup 131}I, {sup 22}Na and {sup 85}Sr at flow rates of 1-50 {mu}L.min{sup -1}. Rock matrix was characterized using {sup 14}C-PMMA method, scanning electron microscopy (SEM), energy dispersive X-ray micro analysis (EDX) and the B.E.T. method. Solute mass flux through a column was modelled by applying the assumption of a linear velocity profile and molecular diffusion. Coupling of the advection and diffusion processes was based on the model of generalised Taylor dispersion in the linear velocity profile. Experiments could be modelled applying a consistent parameterization and transport processes. The results provide evidence that it is possible to investigate matrix diffusion at the laboratory scale. The effects of matrix diffusion were demonstrated on the slightly-sorbing tracer breakthrough curves. Based on scoping calculations matrix diffusion begins to be clearly observable for non-sorbing tracer when the flow rate is 0.1 {mu}L.min{sup -1}. The experimental results presented here cannot be transferred directly to the spatial and temporal scales that prevail in an underground repository. However, the knowledge and understanding of transport and retention processes gained from this study is transferable to different scales from laboratory to in-situ conditions. (authors)

  20. Periosteal Sharpey's fibers: a novel bone matrix regulatory system?

    PubMed

    Aaron, Jean E

    2012-01-01

    Sharpey's "perforating" fibers (SF) are well known skeletally in tooth anchorage. Elsewhere they provide anchorage for the periosteum and are less well documented. Immunohistochemistry has transformed their potential significance by identifying their collagen type III (CIII) content and enabling their mapping in domains as permeating arrays of fibers (5-25 μ thick), protected from osteoclastic resorption by their poor mineralization. As periosteal extensions they are crucial in early skeletal development and central to intramembranous bone healing, providing unique microanatomical avenues for musculoskeletal exchange, their composition (e.g., collagen type VI, elastin, tenascin) combined with a multiaxial pattern of insertion suggesting a role more complex than attachment alone would justify. A proportion permeate the cortex to the endosteum (and beyond), fusing into a CIII-rich osteoid layer (<2 μ thick) encompassing all resting surfaces, and with which they apparently integrate into a PERIOSTEAL-SHARPEY FIBER-ENDOSTEUM (PSE) structural continuum. This intraosseous system behaves in favor of bone loss or gain depending upon extraneous stimuli (i.e., like Frost's hypothetical "mechanostat"). Thus, the birefringent fibers are sensitive to humoral factors (e.g., estrogen causes retraction, rat femur model), physical activity (e.g., running causes expansion, rat model), aging (e.g., causes fragmentation, pig mandible model), and pathology (e.g., atrophied in osteoporosis, hypertrophied in osteoarthritis, human proximal femur), and with encroaching mineral particles hardening the usually soft parts. In this way the unobtrusive periosteal SF network may regulate bone status, perhaps even contributing to predictable "hotspots" of trabecular disconnection, particularly at sites of tension prone to fatigue, and with the network deteriorating significantly before bone matrix loss.

  1. Score Gains on "g"-Loaded Tests: No "g"

    ERIC Educational Resources Information Center

    te Nijenhuis, Jan; van Vianen, Annelies E. M.; van der Flier, Henk

    2007-01-01

    IQ scores provide the best general predictor of success in education, job training, and work. However, there are many ways in which IQ scores can be increased, for instance by means of retesting or participation in learning potential training programs. What is the nature of these score gains? Jensen [Jensen, A. R. (1998a). "The g factor: The…

  2. Cell responses and hemocompatibility of g-HA/PLA composites.

    PubMed

    Li, Jia; Zheng, Wei; Zheng, Yufeng; Lou, Xia

    2011-04-01

    The objective of this study was to investigate the hemocompatibility and cell responses to some novel poly(L-lactide) (PLA) composites containing surface modified hydroxyapatite particles for potential applications as a bone substitute material. The surface of hydroxyapatite (HA) particles was first grafted with L-lactic acid oligomers to form grafted HA (g-HA) particles. The g-HA particles were further blended with PLA to prepare g-HA/PLA composites. Our previous study has shown significant improvement in tensile properties of these materials due to the enhanced interfacial adhesion between the polymer matrix and HA particles. To further investigate the potential applications of these composites in bone repair and other orthopedic surgeries, a series of in vitro and in vivo experiments were conducted to examine the cell responses and hemocompatibility of the materials. In vitro experiments showed that the g-HA/PLA composites were well tolerated by the L-929 cells. Hemolysis of the composites was lower than that of pure PLA. Subcutaneous implantation demonstrated that the g-HA/PLA composites were more favorable than the control materials for soft tissue responses. The results suggested that the g-HA/PLA composites are promising and safe materials with potential applications in tissue engineering.

  3. The properties of g-modes in layered semiconvection

    NASA Astrophysics Data System (ADS)

    Belyaev, Mikhail A.; Quataert, Eliot; Fuller, Jim

    2015-09-01

    We study low-frequency waves that propagate in a region of layered semiconvection. Layered semiconvection is predicted to be present in stellar and planetary interiors and can significantly modify the rate of thermal and compositional mixing. We derive a series of analytical dispersion relations for plane-parallel layered semiconvection in the Boussinesq approximation using a matrix transfer formalism. We find that like a continuously stratified medium, a semiconvective staircase - in which small convective regions are separated by sharp density jumps - supports internal gravity waves (g-modes). When the wavelength is much longer than the distance between semiconvective steps, these behave nearly like g-modes in a continuously stratified medium. However, the g-mode period spacing in a semiconvective region is systematically smaller than in a continuously stratified medium, and it decreases with decreasing mode frequency. When the g-mode wavelength becomes comparable to the distance between semiconvective steps, the g-mode frequencies deviate significantly from those of a continuously stratified medium (the frequencies are higher). g-modes with vertical wavelengths smaller than the distance between semiconvective steps are evanescent and do not propagate in the staircase. Thus, there is a lower cut-off frequency for a given horizontal wavenumber. We generalize our results to gravitoinertial waves relevant for rapidly rotating stars and planets. Finally, we assess the prospects for detecting layered semiconvection using astero/planetary seismology.

  4. TRUPACT-II Hydrogen G-Valve Program Test Plan

    SciTech Connect

    Mroz, Eugene J.

    1999-01-01

    This test plan describes the objectives, scope, participants, and components of the Transuranic Package Transporter-II (TRUPACT-II) Hydrogen G-Value Program (GH2P). The GH2P builds on the experience, results, and experimental setup of the TRUPACT-II Matrix Depletion Program (MDP) to establish effective hydrogen G-values (G-values) for additional waste matrices. This plan details the experimental design and test matrices for experiments to measure the G-value for additional waste matrices, including first- and second-stage sludges at the Idaho National Engineering and Environmental Laboratory, and molten salt extraction residues with varying amounts of residual moisture (i.e., unbound water). Data collected from the GH2P will be used to support an application to the US Nuclear Regulatory Commission for G-values and corresponding wattage limits for the TRUPACT-II payloads containing these waste matrices. The testing will also evaluate the ability to determine G-values on a waste stream basis.

  5. Rotation of methyl radicals in a solid argon matrix

    NASA Astrophysics Data System (ADS)

    Popov, Evgeny; Kiljunen, Toni; Kunttu, Henrik; Eloranta, Jussi

    2007-04-01

    Electron spin resonance (ESR) measurements were carried out to study the rotation of methyl radicals (CH3) in a solid argon matrix at 14-35K temperatures. The radicals were produced by dissociating methane by plasma bursts generated either by a focused 193nm laser radiation or a radio frequency discharge device during the gas condensation on the substrate. The ESR spectrum exhibits axial symmetry at the lowest temperature and is ascribed to ground state molecules with symmetric total nuclear spin function I =3/2. The hyperfine anisotropy (A‖-A⊥) was found to be -0.01mT, whereas that of the g value was 2.5×10-5. The anisotropy is observed for the first time in Ar and is manifested by the splitting of the low-field transition. Elevation of temperature leads reversibly to the appearance of excited state contribution having antisymmetric I=1/2. As a function of the sample temperature, the relative intensities of symmetric and antisymmetric spin states corresponding to ground and excited rotor states, respectively, proton hyperfine and electron g-tensor components, and spin-lattice relaxation rates were determined by a numerical fitting procedure. The experimental observations were interpreted in terms of a free rotation about the C3 axis and a thermal activation of the C2-type rotations above 15K. The ground and excited rotational state energy levels were found to be separated by 11.2cm-1 and to exhibit significantly different spin-lattice coupling. A crystal field model has been applied to evaluate the energy levels of the hindered rotor in the matrix, and crystal field parameter ɛ4=-200cm-1, corresponding to a 60cm-1 effective potential barrier for rotation of the C3 axis, was obtained.

  6. Zero-G Workstation Design

    NASA Technical Reports Server (NTRS)

    Gundersen, R. T.; Bond, R. L.

    1976-01-01

    Zero-g workstations were designed throughout manned spaceflight, based on different criteria and requirements for different programs. The history of design of these workstations is presented along with a thorough evaluation of selected Skylab workstations (the best zero-g experience available on the subject). The results were applied to on-going and future programs, with special emphasis on the correlation of neutral body posture in zero-g to workstation design. Where selected samples of shuttle orbiter workstations are shown as currently designed and compared to experience gained during prior programs in terms of man machine interface design, the evaluations were done in a generic sense to show the methods of applying evaluative techniques.

  7. Differential Die-Away Analysis for detection of 235U in metallic matrix

    NASA Astrophysics Data System (ADS)

    Kashyap, Yogesh; Agrawal, Ashish; Roy, Tushar; Sarkar, P. S.; Shukla, Mayank; Patel, Tarun; Sinha, Amar

    2016-01-01

    Differential Die-Away Analysis is a powerful tool for detecting small quantity of fissile material even if it is shielded or placed in non-fissile matrix. The technique can be used to monitor and characterize fissile content for nuclear waste assay. In this paper, we have discussed the application of differential die away technique for detection of small quantity of fissile material in nuclear waste assay. Feasibility experiments to optimize various parameters have been carried out for detection of 235U in metallic matrix and reported in this paper. A minimum quantity of 1 g of 235U in 150 kg of metallic matrix has been detected in the experimental configuration being reported.

  8. Local delamination in laminates with angle ply matrix cracks. Part 2: Delamination fracture analysis and fatigue characterization

    NASA Technical Reports Server (NTRS)

    Obrien, T. Kevin

    1991-01-01

    Constant amplitude tension-tension fatigue tests were conducted on AS4/3501-6 graphite/epoxy (02/ theta sub 2/ -(theta sub 2))sub s laminates, where theta was 15, 20, 25, or 30 degrees. Fatigue tests were conducted at a frequency of 5 Hz and an R-ratio of 0.1. Dye penetrant enhanced x-radiography was used to document the onset of matrix cracking in the central -(theta) degree plies, and the subsequent onset of local delaminations in the theta/ -(theta) interface at the intersection of the matrix cracks and the free edge, as a function of the number of fatigue cycles. Two strain energy release rate solutions for local delamination from matrix cracks were derived: one for a local delamination growing from an angle ply matrix crack with a uniform delamination growing from an angle ply matrix crack with a triangular shaped delamination area that extended only partially into the laminate width from the free edge. Plots of G(max) vs. N were generated to assess the accuracy of these G solutions. The influence of residual thermal and moisture stresses on G were also quantified. However, a detailed analysis of the G components and a mixed-mode fatigue failure criterion for this material may be needed to predict the fatigue behavior of these laminates.

  9. Constant Applied Force Stimulates Osteoblast Proliferation Via Matrix-Integrin-Signaling Pathways

    NASA Technical Reports Server (NTRS)

    Vercoutere, W.; Parra, M.; Roden, C.; DaCosta, M.; Wing, A.; Damsky, C.; Holton, E.; Searby, N.; Globus, R.; Almeida, E. A. C.

    2003-01-01

    Reduced weight-bearing caused by immobilization, bed-rest or microgravity leads to atrophy in mechanosensitive tissue such as muscle and bone. We hypothesize that bone tissue requires earth s gravity (1-g) for the maintenance of extracellular matrix, integrin, and kinase-mediated cell growth and survival pathways. We investigate the role of matrix-integrin signaling in bone cells using cell culture centrifugation to provide different levels of hypergravity mechanostimulation. The 10-50-g range we use also mimics physiological intermedullary pressure (1.2 - 5 kPa). 24 hours at 50-g increased primary rat osteoblast proliferation on collagen Type I and fibronectin, but not laminin or uncoated plastic. BrdU incorporation in primary osteoblasts over 24 h showed hypergravity increased the number of cells actively synthesizing DNA from about 60% at 1-g to over 90% at 25-g. Primary rat fibroblasts grown at 50-g (24 h) showed no proliferation increase, suggesting this is a tissue-specific phenomenon. These results suggest that the betal and alpha4 integrins may be involved. To further test this, we used osteocytic-like MLO-Y4 cells that showed increased proliferation at 1-g with stable expression of a betal integrin cytoplasmic tail and transmembrane domain construct. At 50-g, MLO-Y4/betal cells showed greater MAPK activation than MLO-Y4 vector controls, suggesting that betal integrin is involved in transducing mitogenic signals in response to hypergravity. Preliminary results also show that interfering with the alpha4 integrin in primary osteoblasts grown on fibronectin blocked the proliferation response. These results indicate that cells from mechanosensitive bone tissue can respond to gravity-generated forces, and this response involves specific matrix and integrin-dependent signaling pathways.

  10. G2 Flywheel Module Design

    NASA Technical Reports Server (NTRS)

    Jensen, Ralph H.; Dever, Timothy P.

    2006-01-01

    Design of a flywheel module, designated the G2 module, is described. The G2 flywheel is a 60,000 RPM, 525 W-hr, 1 kW system designed for a laboratory environment; it will be used for component testing and system demonstrations, with the goal of applying flywheels to aerospace energy storage and integrated power and attitude control (IPACS) applications. G2 has a modular design, which allows for new motors, magnetic bearings, touchdown bearings, and rotors to be installed without a complete redesign of the system. This design process involves several engineering disciplines, and requirements are developed for the speed, energy storage, power level, and operating environment. The G2 rotor system consists of a multilayer carbon fiber rim with a titanium hub on which the other components mount, and rotordynamics analysis is conducted to ensure rigid and flexible rotor modes are controllable or outside of the operating speed range. Magnetic bearings are sized using 1-D magnetic circuit analysis and refined using 3-D finite element analysis. The G2 magnetic bearing system was designed by Texas A&M and has redundancy which allows derated operation after the loss of some components, and an existing liquid cooled two pole permanent magnet motor/generator is used. The touchdown bearing system is designed with a squeeze film damper system allowing spin down from full operating speed in case of a magnetic bearing failure. The G2 flywheel will enable module level demonstrations of component technology, and will be a key building block in system level attitude control and IPACS demonstrations.

  11. The G-LOC Syndrome

    DTIC Science & Technology

    1990-10-31

    C 11 TITLE (include Security Classification) The G-LOC Syndrome 12 PERSONAL AuTHOR( S , James E. Wninnery, M.D., Ph.D. 13a TYPE OF REPORT 1,3b TIME...AD-A239 561 Report No. NADC-91042-60 A 561lllii ilfr THE G-LOC SYNDROME James E. Whinnery, M.D., Ph.D. Air Vehicle and Crew Systems Technology...Group 90 Test & Evaluation Group PRODUCT ENDORSEMENT - The discussion or Instructions concerning commercial products herein do not constitute an

  12. The g2 Structure Function

    SciTech Connect

    Matthias Burkardt

    2009-07-01

    Polarized structure functions at low $Q^2$ have the physical interpretation of (generalized) spin polarizabilities. At high $Q^2$, the polarized parton distribution $g_2(x)$ provides access to quark-gluon correlations in the nucleon. We discuss the interpretation of the $x^2$ moment of $\\bar{g}_2(x)$ as an average transverse force on quarks in deep-inelastic scattering from a transversely polarized target. Qualitative connections with generalized parton distributions are emphasized. The $x^2$ moment of the chirally-odd twist-3 parton distribution $e(x)$ provides information on the dependence of the average transverse force on the transversity of the quark.

  13. High-frequency matrix converter with square wave input

    DOEpatents

    Carr, Joseph Alexander; Balda, Juan Carlos

    2015-03-31

    A device for producing an alternating current output voltage from a high-frequency, square-wave input voltage comprising, high-frequency, square-wave input a matrix converter and a control system. The matrix converter comprises a plurality of electrical switches. The high-frequency input and the matrix converter are electrically connected to each other. The control system is connected to each switch of the matrix converter. The control system is electrically connected to the input of the matrix converter. The control system is configured to operate each electrical switch of the matrix converter converting a high-frequency, square-wave input voltage across the first input port of the matrix converter and the second input port of the matrix converter to an alternating current output voltage at the output of the matrix converter.

  14. Metal Matrix Microencapsulated (M3) fuel neutronics performance in PWRs

    SciTech Connect

    Fratoni, Massimiliano; Terrani, Kurt A

    2012-01-01

    Metal Matrix Microencapsulated (M3) fuel consists of TRISO or BISO coated fuel particles directly dispersed in a matrix of zirconium metal to form a solid rod (Fig. 1). In this integral fuel concept the cladding tube and the failure mechanisms associated with it have been eliminated. In this manner pellet-clad-interactions (PCI), thin tube failure due to oxidation and hydriding, and tube pressurization and burst will be absent. M3 fuel, given the high stiffness of the integral rod design, could as well improve grid-to-rod wear behavior. Overall M3 fuel, compared to existing fuel designs, is expected to provide greatly improved operational performance. Multiple barriers to fission product release (ceramic coating layers in the coated fuel particle and te metal matrix) and the high thermal conductivity zirconium alloy metal matrix contribute to the enhancement in fuel behavior. The discontinuous nature of fissile material encapsulated in coated particles provides additional assistance; for instance if the M3 fuel rod is snapped into multiple pieces, only the limited number of fuel particles at the failure cross section are susceptible to release fission products. This is in contrast to the conventional oxide fuel where the presence of a small opening in the cladding provides the pathway for release of the entire inventory of fission products from the fuel rod. While conventional metal fuels (e.g. U-Zr and U-Mo) are typically expected to experience large swelling under irradiation due to the high degree of damage from fission fragments and introduction of fission gas into the lattice, this is not the case for M3 fuels. The fissile portion of the fuel is contained within the coated particle where enough room is available to accommodate fission gases and kernel swelling. The zirconium metal matrix will not be exposed to fission products and its swelling is known to be very limited when exposed solely to neutrons. Under design basis RIA and LOCA, fuel performance will be

  15. Application of transmissibility matrix and random matrix to Bayesian system identification with response measurements only

    NASA Astrophysics Data System (ADS)

    Yan, Wang-Ji; Katafygiotis, Lambros S.

    2016-10-01

    The problem of stochastic system identification utilizing response measurements only is considered in this paper. A negative log-likelihood function utilized to determine the posterior most probable parameters and their associated uncertainties is formulated by incorporating transmissibility matrix concept, random matrix theory and Bayes’ theorem. A numerically iterative coupled method involving the optimization of the parameters in groups is proposed so as to reduce the dimension of the numerical optimization problem involved. The initial guess for the parameters to be optimized is also properly estimated through asymptotic analysis. One novel feature of the proposed method is to avoid repeated time-consuming evaluation of the determinant and inverse of the covariance matrix during optimization due to exploring the statistical properties of the trace of Wishart matrix. The proposed method requires no information about the model of the external input. The theory described in this work is illustrated with synthetic data and field data measured from a laboratory model installed with wireless sensors.

  16. Dentin matrix degradation by host matrix metalloproteinases: inhibition and clinical perspectives toward regeneration

    PubMed Central

    Chaussain, Catherine; Boukpessi, Tchilalo; Khaddam, Mayssam; Tjaderhane, Leo; George, Anne; Menashi, Suzanne

    2013-01-01

    Bacterial enzymes have long been considered solely accountable for the degradation of the dentin matrix during the carious process. However, the emerging literature suggests that host-derived enzymes, and in particular the matrix metalloproteinases (MMPs) contained in dentin and saliva can play a major role in this process by their ability to degrade the dentin matrix from within. These findings are important since they open new therapeutic options for caries prevention and treatment. The possibility of using MMP inhibitors to interfere with dentin caries progression is discussed. Furthermore, the potential release of bioactive peptides by the enzymatic cleavage of dentin matrix proteins by MMPs during the carious process is discussed. These peptides, once identified, may constitute promising therapeutical tools for tooth and bone regeneration. PMID:24198787

  17. Accuracy of whole-genome prediction using a genetic architecture-enhanced variance-covariance matrix.

    PubMed

    Zhang, Zhe; Erbe, Malena; He, Jinlong; Ober, Ulrike; Gao, Ning; Zhang, Hao; Simianer, Henner; Li, Jiaqi

    2015-02-09

    Obtaining accurate predictions of unobserved genetic or phenotypic values for complex traits in animal, plant, and human populations is possible through whole-genome prediction (WGP), a combined analysis of genotypic and phenotypic data. Because the underlying genetic architecture of the trait of interest is an important factor affecting model selection, we propose a new strategy, termed BLUP|GA (BLUP-given genetic architecture), which can use genetic architecture information within the dataset at hand rather than from public sources. This is achieved by using a trait-specific covariance matrix ( T: ), which is a weighted sum of a genetic architecture part ( S: matrix) and the realized relationship matrix ( G: ). The algorithm of BLUP|GA (BLUP-given genetic architecture) is provided and illustrated with real and simulated datasets. Predictive ability of BLUP|GA was validated with three model traits in a dairy cattle dataset and 11 traits in three public datasets with a variety of genetic architectures and compared with GBLUP and other approaches. Results show that BLUP|GA outperformed GBLUP in 20 of 21 scenarios in the dairy cattle dataset and outperformed GBLUP, BayesA, and BayesB in 12 of 13 traits in the analyzed public datasets. Further analyses showed that the difference of accuracies for BLUP|GA and GBLUP significantly correlate with the distance between the T: and G: matrices. The new strategy applied in BLUP|GA is a favorable and flexible alternative to the standard GBLUP model, allowing to account for the genetic architecture of the quantitative trait under consideration when necessary. This feature is mainly due to the increased similarity between the trait-specific relationship matrix ( T: matrix) and the genetic relationship matrix at unobserved causal loci. Applying BLUP|GA in WGP would ease the burden of model selection.

  18. Human Cytomegalovirus gH/gL Forms a Stable Complex with the Fusion Protein gB in Virions.

    PubMed

    Vanarsdall, Adam L; Howard, Paul W; Wisner, Todd W; Johnson, David C

    2016-04-01

    Human cytomegalovirus (HCMV) is a ubiquitous virus that is a major pathogen in newborns and immunocompromised or immunosuppressed patients. HCMV infects a wide variety of cell types using distinct entry pathways that involve different forms of the gH/gL glycoprotein: gH/gL/gO and gH/gL/UL128-131 as well as the viral fusion glycoprotein, gB. However, the minimal or core fusion machinery (sufficient for cell-cell fusion) is just gH/gL and gB. Here, we demonstrate that HCMV gB and gH/gL form a stable complex early after their synthesis and in the absence of other viral proteins. gH/gL can interact with gB mutants that are unable to mediate cell-cell fusion. gB-gH/gL complexes included as much as 16-50% of the total gH/gL in HCMV virus particles. In contrast, only small amounts of gH/gL/gO and gH/gL/UL128-131 complexes were found associated with gB. All herpesviruses express gB and gH/gL molecules and most models describing herpesvirus entry suggest that gH/gL interacts with gB to mediate membrane fusion, although there is no direct evidence for this. For herpes simplex virus (HSV-1) it has been suggested that after receptor binding gH/gL binds to gB either just before, or coincident with membrane fusion. Therefore, our results have major implications for these models, demonstrating that HCMV gB and gH/gL forms stable gB-gH/gL complexes that are incorporated virions without receptor binding or membrane fusion. Moreover, our data is the best support to date for the proposal that gH/gL interacts with gB.

  19. Human Cytomegalovirus gH/gL Forms a Stable Complex with the Fusion Protein gB in Virions

    PubMed Central

    Vanarsdall, Adam L.; Howard, Paul W.; Wisner, Todd W.; Johnson, David C.

    2016-01-01

    Human cytomegalovirus (HCMV) is a ubiquitous virus that is a major pathogen in newborns and immunocompromised or immunosuppressed patients. HCMV infects a wide variety of cell types using distinct entry pathways that involve different forms of the gH/gL glycoprotein: gH/gL/gO and gH/gL/UL128-131 as well as the viral fusion glycoprotein, gB. However, the minimal or core fusion machinery (sufficient for cell-cell fusion) is just gH/gL and gB. Here, we demonstrate that HCMV gB and gH/gL form a stable complex early after their synthesis and in the absence of other viral proteins. gH/gL can interact with gB mutants that are unable to mediate cell-cell fusion. gB-gH/gL complexes included as much as 16–50% of the total gH/gL in HCMV virus particles. In contrast, only small amounts of gH/gL/gO and gH/gL/UL128-131 complexes were found associated with gB. All herpesviruses express gB and gH/gL molecules and most models describing herpesvirus entry suggest that gH/gL interacts with gB to mediate membrane fusion, although there is no direct evidence for this. For herpes simplex virus (HSV-1) it has been suggested that after receptor binding gH/gL binds to gB either just before, or coincident with membrane fusion. Therefore, our results have major implications for these models, demonstrating that HCMV gB and gH/gL forms stable gB-gH/gL complexes that are incorporated virions without receptor binding or membrane fusion. Moreover, our data is the best support to date for the proposal that gH/gL interacts with gB. PMID:27082872

  20. Combined effect of matrix cracking and stress-free edge on delamination

    NASA Technical Reports Server (NTRS)

    Salpekar, S. A.; Obrien, T. K.

    1990-01-01

    The effect of the stress-free edge on the growth of local delaminations initiating from a matrix crack in (0 sub 2/90 sub 4) sub s and (+ or - 45.90 sub 4) sub s glass epoxy laminates is investigated using 3-D finite element analysis. The presence of high interlaminar normal stresses at the intersection (corner) of the matrix crack with the stress-free edge, suggests that a mode I delamination may initiate at the corners. The strain energy release rates (G) were calculated by modeling a uniform through-width delamination and two inclined delaminations at 10.6 deg and 45 deg to the matrix crack. All components of G have high values near the free edges. The mode I component of G is high at small delamination length and becomes zero for a delamination length of one-ply thickness. The total G values near the free edge agreed well with previously derived closed form solution. The quasi-3D solutions agreed well with the 3-D interior solutions.

  1. Effect of matrix on the dry friction coefficient of unidirectional fiber-reinforced composite

    NASA Astrophysics Data System (ADS)

    Vettegren, V. I.; Savitskii, A. V.; Lyashkov, A. I.; Mamalimov, R. I.

    2008-10-01

    The coefficients of dry rest (μ0) and sliding (μ s ) friction on a polished disk made of quenched steel have been measured for various polymer matrices and fibers and for a composite unidirectionally reinforced with poly(amidobenzimidazole) (PABI) fibers. It is established that μ0 > μ s for matrices and fibers with glass transition temperatures T g below room temperature T R , otherwise μ0 ≈ μ s . This effect is explained by a sharp growth in the plasticity of polymers at T g , which leads to an increase in the polymer-steel contact area. For a composite with T g > T R , the dry friction coefficients obey the relation μ0 ≈ μ s ≈ μ e / C, where μ e is the coefficients of sliding friction of PABI fibers and C is their concentration. For T g < T R (plastic matrix), the friction coefficients of the composite and matrix are close because the latter cannot hold the fiber ends during friction. As a result, they are bent and aligned along the matrix surface or embedded in the surface layer.

  2. Optimizing Tpetra%3CU%2B2019%3Es sparse matrix-matrix multiplication routine.

    SciTech Connect

    Nusbaum, Kurtis Lee

    2011-08-01

    Over the course of the last year, a sparse matrix-matrix multiplication routine has been developed for the Tpetra package. This routine is based on the same algorithm that is used in EpetraExt with heavy modifications. Since it achieved a working state, several major optimizations have been made in an effort to speed up the routine. This report will discuss the optimizations made to the routine, its current state, and where future work needs to be done.

  3. John G. Kemeny: Computing Pioneer.

    ERIC Educational Resources Information Center

    Steen, Lynn Arthur

    1983-01-01

    John G. Kemeny, co-author of the BASIC programing language and co-developer of the Dartmouth Time-Sharing System, is interviewed. He responds to questions on computer languages, the role of computer science, future uses of computers, and mathematics instruction. (MP)

  4. Muon g-2 Experiment Shimming

    SciTech Connect

    Kiburg, Brendan

    2016-06-28

    The Muon g-2 experiment at Fermilab will use as its primary instrument a 52-foot-wide electromagnet that creates a precise magnetic field. In this video, Fermilab's Brendan Kiburg explains the lengthy process of finely "shimming" that magnetic field into shape.

  5. The challenge of G-376

    NASA Technical Reports Server (NTRS)

    Dorsey, George L.

    1988-01-01

    The entire G-376 project is reviewed from history, experiment concept, construction, testing, through post flight data reduction. For each of these topics, one or two specific experiments is used as an example to develop that topic. A summary of the 14 experiments is given in tabular form.

  6. Muon g-2 Experiment Shimming

    ScienceCinema

    Kiburg, Brendan

    2016-07-12

    The Muon g-2 experiment at Fermilab will use as its primary instrument a 52-foot-wide electromagnet that creates a precise magnetic field. In this video, Fermilab's Brendan Kiburg explains the lengthy process of finely "shimming" that magnetic field into shape.

  7. Penicillin G (Potassium, Sodium) Injection

    MedlinePlus

    ... if you have or have ever had asthma, allergies, hay fever, hives, heart failure, or kidney or liver disease.tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while receiving penicillin G injection, call your doctor.

  8. Carter G. Woodson Book Awards.

    ERIC Educational Resources Information Center

    Social Education, 2000

    2000-01-01

    Presents the recipients of the 1999 Carter G. Woodson book awards that honor books focusing on ethnic minorities and race relations that are appropriate for elementary and secondary levels. Includes books that cover topics such as life for Japanese Americans in internment camps and lives of 12 black women. (CMK)

  9. ROY G. BIV Never Forgets.

    ERIC Educational Resources Information Center

    Jackson, Michael C.; Anderson, Norman D.

    1988-01-01

    Discusses the value of memorized factual material in science. Describes the use of mnemonic devices to facilitate memorization. Provides a list of 14 mnemonic devices commonly used in science other than ROY G. BIV, which is used to remember the colors of the visible spectrum. (CW)

  10. Rovibrational matrix elements of the quadrupole moment of N2 in a solid parahydrogen matrix

    NASA Astrophysics Data System (ADS)

    Mishra, Adya P.; Balasubramanian, T. K.

    2008-11-01

    The present work pertains to the study of the rotational dynamics of N2 molecules solvated in a matrix of solid para-H2. It is shown that the mixing of the rotational states due to the anisotropic part of the N2-H2 pair potential in the solid gives rise to an additional 5.4% contribution to the intensity of quadrupole-induced double transitions involving N2-H2 pair. Hence the recently reported quadrupole moment matrix element of N2 in a solid para-H2 crystal [A. P. Mishra and T. K. Balasubramanian, J. Chem. Phys. 125, 124507 (2006)], which was deduced from a comparison of the theoretical intensity (with rotational mixing of states neglected) with the measured value is larger by ˜2.7%. The ground electronic state rovibrational matrix elements ⟨v'J'|Q2(r)|vJ⟩ of N2 molecule in a solid parahydrogen matrix for v,v'≤1 and J,J'≤4 have also been computed by taking into account the changes in the intramolecular potential of N2 due to the intermolecular interaction in the matrix. The computed quadrupole moment matrix elements agree well with a few available values (for v =v'=0) deduced from the observed transitions.

  11. Matrix metalloproteinases and other matrix proteinases in relation to cariology: the era of 'dentin degradomics'.

    PubMed

    Tjäderhane, Leo; Buzalaf, Marília Afonso Rabelo; Carrilho, Marcela; Chaussain, Catherine

    2015-01-01

    Dentin organic matrix, with type I collagen as the main component, is exposed after demineralization in dentinal caries, erosion or acidic conditioning during adhesive composite restorative treatment. This exposed matrix is prone to slow hydrolytic degradation by host collagenolytic enzymes, matrix metalloproteinases (MMPs) and cysteine cathepsins. Here we review the recent findings demonstrating that inhibition of salivary or dentin endogenous collagenolytic enzymes may provide preventive means against progression of caries or erosion, just as they have been shown to retain the integrity and improve the longevity of resin composite filling bonding to dentin. This paper also presents the case that the organic matrix in caries-affected dentin may not be preserved as intact as previously considered. In partially demineralized dentin, MMPs and cysteine cathepsins with the ability to cleave off the terminal non-helical ends of collagen molecules (telopeptides) may lead to the gradual loss of intramolecular gap areas. This would seriously compromise the matrix ability for intrafibrillar remineralization, which is considered essential in restoring the dentin's mechanical properties. More detailed data of the enzymes responsible and their detailed function in dentin-destructive conditions may not only help to find new and better preventive means, but better preservation of demineralized dentin collagenous matrix may also facilitate true biological remineralization for the better restoration of tooth structural and mechanical integrity and mechanical properties.

  12. Mid-infrared matrix assisted laser desorption ionization with a water/glycerol matrix

    NASA Astrophysics Data System (ADS)

    Caldwell, Kathleen L.; Murray, Kermit K.

    1998-05-01

    Matrix-assisted laser desorption ionization (MALDI) mass spectra were obtained using a water and glycerol matrix with a tunable mid-infrared optical parametric oscillator. The matrix consists of a 1:1 mixture of water and glycerol deposited on a thin layer of nitrocellulose and cooled to -30°C. When exposed to vacuum, most of the water evaporates, leaving a matrix of glycerol with residual water. The peptide bradykinin and the protein bovine insulin were used to test this new matrix. Mass spectra were obtained for bradykinin between 2.76 and 3.1 μm with the maximum analyte signal at 2.8 μm. Mass resolution in excess of 2000 for bradykinin and 500 for insulin was obtained with delayed ion extraction and a linear time of flight mass spectrometer. The addition of nitrocellulose to the matrix resulted in exceptionally durable samples: more than 10,000 laser shots which produced analyte signal could be obtained from a single sample spot.

  13. Pendulum impact resistance of tungsten fiber/metal matrix composites.

    NASA Technical Reports Server (NTRS)

    Winsa, E. A.; Petrasek, D. W.

    1972-01-01

    The impact properties of copper, copper-10 nickel, and a superalloy matrix reinforced with tungsten fibers were studied. In most cases the following increased composite impact strength: increased fiber or matrix toughness, decreased fiber-matrix reaction, increased test temperature, hot working and heat treatment. Notch sensitivity was reduced by increasing fiber or matrix toughness. The effect of fiber content depended on the relative toughness of the fibers and matrix. Above 530 K a 60 volume per cent superalloy matrix composite had a greater impact strength than a turbine blade superalloy, whereas below 530 K a hot worked 56 volume per cent composite had a greater impact strength than the superalloy.

  14. Conjugation of extracellular matrix proteins to basal lamina analogs enhances keratinocyte attachment.

    PubMed

    Bush, Katie A; Downing, Brett R; Walsh, Sarah E; Pins, George D

    2007-02-01

    The dermal-epidermal junction of skin contains extracellular matrix proteins that are involved in initiating and controlling keratinocyte signaling events such as attachment, proliferation, and terminal differentiation. To characterize the relationship between extracellular matrix proteins and keratinocyte attachment, a biomimetic design approach was used to precisely tailor the surface of basal lamina analogs with biochemistries that emulate the native biochemical composition found at the dermal-epidermal junction. A high-throughput screening device was developed by our laboratory that allows for the simultaneous investigation of the conjugation of individual extracellular matrix proteins (e.g. collagen type I, collagen type IV, laminin, or fibronectin) as well as their effect on keratinocyte attachment, on the surface of an implantable collagen membrane. Fluorescence microscopy coupled with quantitative digital image analyses indicated that the extracellular matrix proteins adsorbed to the collagen-GAG membranes in a dose-dependent manner. To determine the relationship between extracellular matrix protein signaling cues and keratinocyte attachment, cells were seeded on protein-conjugated collagen-GAG membranes and a tetrazolium-based colorimetric assay was used to quantify viable keratinocyte attachment. Our results indicate that keratinocyte attachment was significantly enhanced on the surfaces of collagen membranes that were conjugated with fibronectin and type IV collagen. These findings define a set of design parameters that will enhance keratinocyte binding efficiency on the surface of collagen membranes and ultimately improve the rate of epithelialization for dermal equivalents.

  15. Modeling the Matrix of Articular Cartilage Using a Continuous Fiber Angular Distribution Predicts Many Observed Phenomena

    PubMed Central

    Ateshian, Gerard A.; Rajan, Vikram; Chahine, Nadeen O.; Canal, Clare E.; Hung, Clark T.

    2010-01-01

    Background Cartilage is a hydrated soft tissue whose solid matrix consists of negatively charged proteoglycans enmeshed within a fibrillar collagen network. Though many aspects of cartilage mechanics are well understood today, most notably in the context of porous media mechanics, there remain a number of responses observed experimentally whose prediction from theory has been challenging. Method of approach In this study the solid matrix of cartilage is modeled with a continuous fiber angular distribution, where fibers can only sustain tension, swelled by the osmotic pressure of a proteoglycan ground matrix. Results It is shown that this representation of cartilage can predict a number of observed phenomena in relation to the tissue’s equilibrium response to mechanical and osmotic loading, when flow-dependent and flow-independent viscoelastic effects have subsided. In particular, this model can predict the transition of Poisson’s ratio from very low values in compression (~0.02) to very high values in tension (~2.0). Most of these phenomena cannot be explained when using only three orthogonal fiber bundles to describe the tissue matrix, a common modeling assumption used to date. Conclusions The main picture emerging from this analysis is that the anisotropy of the fibrillar matrix of articular cartilage is intimately dependent on the mechanism of tensed fiber recruitment, in the manner suggested by our recent theoretical study (G. A. Ateshian. J Biomech Eng, 129(2):240-9, 2007). PMID:19449957

  16. Alterations in the biosynthesis of extracellular matrix molecules in connective tissues by electric and magnetic fields

    SciTech Connect

    Ciombor, D.M.

    1992-01-01

    Pulsed electromagnetic fields (PEMFs) of certain configurations have been shown to be effective clinically in promoting the healing of fracture non-unions and are believed to enhance calcification of extracellular matrix. In vitro studies have suggested that PEMFs may also have the effect of modifying the extracellular matrix by promoting the synthesis of matrix molecules. This study examines the effect of one particular type of PEMF and a sinusoidal continuous wave upon the extracellular matrix and calcification of endochondral ossification in vivo. The pulsed magnetic field (SS-22) utilized in these studies is being used clinically for the treatment of fracture non-unions, a condition in which the bone is not restored to form or function. The sinusoidal continuous wave was designed to provide a 5 Gauss amplitude at a 15 Hz. rate. The synthesis of cartilage molecules is enhanced by this type of PEMF and since wave and subsequent endochondral calcification is stimulated. Histomorphometric studies indicate that the maturation of bone trabeculae is also promoted by this type of PEMF stimulation. These results indicate that a specific PEMF or continuous waveform can change the composition of cartilage extracellular matrix in vivo and raises the possibility that the effects on other processes of endochondral ossification (e.g., fracture healing and growth plates) may occur through a similar mechanism.

  17. Insights into Nuclear Triaxiality from Interference Effects in E2 Matrix Elements

    NASA Astrophysics Data System (ADS)

    Allmond, J. M.; Wood, J. L.; Kulp, W. D.

    2007-10-01

    Recently, we have introduced [1] a triaxial rotor model with independent inertia and E2 tensors. The E2 matrix elements [2] of the osmium isotopes (186, 188, 190, and 192) are studied in the framework of this model (59 of 84 E2 matrix elements deviate by 30% or less). It is shown that interference effects in the inertia tensor (K-mixing) and the E2 tensor can lead to significant reductions in the diagonal E2 matrix elements. In some instances, the diagonal E2 matrix elements may decrease with increasing spin. Additionally, a sum rule for diagonal E2 matrix elements is shown and used to explore missing strength from K-admixtures. [1] J.L. Wood, A-M. Oros-Peusquens, R. Zaballa, J.M. Allmond, and W.D. Kulp, Phys. Rev. C 70, 024308 (2004). [2] C.Y. Wu, D. Cline, T. Czosnyka, A. Backlin, C. Baktash, R.M. Diamond, G.D. Dracoulis, L. Hasselgren, H. Kluge, et al., Nucl. Phys. A607, 178 (1996).

  18. Tracer diffusion from a horizontal fracture into the surrounding matrix: measurement by computed tomography.

    PubMed

    Polak, Amir; Grader, Abraham S; Wallach, Rony; Nativ, Ronit

    2003-12-01

    The vertical diffusion of NaI solution from a horizontal fracture into and within the surrounding matrix was tracked and quantified over time using an artificially fractured chalk core (30x5 cm) and a second-generation X-ray computed tomography (CT) scanner. The different tracer-penetration distances imaged in the matrix above and below the horizontal fracture are indicative of a greater tracer mass penetrating into the lower matrix. The enhanced transport in the matrix below the fracture was related to the Rayleigh-Darcy instability induced by the density differences between the heavier tracer solution in the fracture (1.038) and the distilled water that had initially resided in the matrix. Our observations suggest that below the fracture, the tracer is propagated by an advection-diffusion process that is characterized by both higher rates and higher concentrations relative to its propagation by diffusion above the fracture. The experimental results suggest that the prediction of contaminant migration in a rock intersected by both vertical and horizontal (e.g. along bedding planes) fractures is difficult because of density effects that result in different solute-penetration rates.

  19. Enrichment of high-quality spermatozoa in bovine semen: relative effectiveness of three filtration matrixes.

    PubMed

    Cisale, H O; Fischman, M L; Blasi, C D; Fernandez, H A; Gledhill, B L

    2001-05-01

    To be practical, any method for improving bull semen must yield a large quantity of motile spermatozoa. Some separation methods based on physical properties, e.g. filtration, chromatography, centrifugation, washing and pooling, have been reported as satisfactory, but generally are not repeatable. Nevertheless, filtration methods appear to allow the attainment of an acceptable number of spermatozoa, thus allowing such a technique to be introduced in the production of standard bovine semen doses for artificial insemination. The aim of this work was to evaluate systematically the relative effects of three filtration matrixes (silica oxide, glass beads or Sephadexätrade mark) on the improvement of whole ejaculate quality. Analysis of the type of matrix and the volume and height of the filtration column was performed. The only characteristic of the columns that appears to influence ejaculate quality after filtering is the matrix volume. While all matrixes produced improvement of semen quality, SephadexTM was better than the other matrixes tested. An explanation for the mechanism of column filtration is proposed.

  20. Molecular mechanism of lysozyme adsorption onto chemically modified alginate guar gum matrix.

    PubMed

    Brassesco, Ma Emilia; Woitovich Valetti, Nadia; Picó, Guillermo

    2017-03-01

    The equilibrium isotherms and adsorption kinetics of lysozyme (LZ) on epichlorohydrin (Epi) cross-linked alginate-guar gum (Alg-GG) matrix were studied. Adsorption kinetics followed a pseudo-first-order model while the equilibrium isotherm could be represented by the Freundlich equation. The maximal amount of LZ adsorbed onto this matrix was around 2.4mg per g of hydrated matrix at pH 7.00. The adsorption mechanism was associated to a simple diffusion process with a weak columbic interaction between LZ and the matrix. The presence of NaCl 0.3M induced a total displacement of the LZ from the matrix. Under this condition, the percentage of desorbed protein was 95%. Successive cycles of adsorption-washing-elution were performed and the results showed the reversibility of the process and the usefulness of the method for enzyme purification and separation. A last successful step was carried out for the purification of LZ from egg white as natural source. The model proved to be useful applied as a platform design in the isolation and purification of proteins.