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Sample records for g8 summit meeting

  1. [2008 G8 Hokkaido Toyako Summit Meeting Syndrome Surveillance].

    PubMed

    Ohkusa, Yasushi; Yamaguchi, Ryo; Sugiura, Hiroaki; Sugawara, Tamie; Yoshida, Makiko; Shimada, Chie; Hori, Narumi; Sugishita, Yoshiyuki; Yasui, Yoshinori; Sunagawa, Tomimasa; Matsui, Tamano; Taniguchi, Kiyosu; Tada, Yuki; Taya, Keiko; Imamura, Tomoaki; Okabe, Nobuhiko

    2009-05-01

    We conducted syndromic surveillance for the Hokkaido, Japan, Toyako Group of Eight (G8) summit meeting in July 2008 as a counter-measure to bioterrorism attacks and other health emergencies. Surveys were conducted from June 23, two weeks before the summit, to July 23 two weeks after it, with part of those for prescription drugs fully automated, and part by manual input over the World-Wide-Web. Those for ambulance transfer were done similarly. We bought over-the-counter (OTC) sales data from two private research firms in Japan and had the monitor, who had contacts with a private research company, report health conditions via personal computer (PC) or cellphone. We had a virtual conference daily at 9:00 with the local Hokkaido government, local public health center, local Hokkaido public laboratory, the National Institute of Infectious Diseases, and the Ministry of Health, Labor and Welfare to decide whether local public health centers would be required to investigate. Fully automated syndromic surveillance was conducted by 23 pharmacies for prescriptions drugs, and 71 pharmacies provided manual corporate input. One fire department covering Toyako and a VIP support team used fully automated syndromic surveillance and seven Toyako fire departments used manual input. For 79 pharmacies providing OTC sales data, data provision was delayed one day and analysis could not be automated. Four hundred and seventy two households corporate web search for their health conditions. It also automatically analyzed and feed backed. No notable outbreak occurred during the summit, but public health centers investigated seven aberration detected by syndrome surveillance for ambulance transfer. Although a fully automated system was concidered best for early outbreak detection manual input and analysis were also required. Routine, fully automatied syndromic surveillance remains to be realized in Japan.

  2. Junior G8 Summit: Speaking Out with a "Passion for Peace"

    ERIC Educational Resources Information Center

    Education Canada, 2007

    2007-01-01

    The Junior G8 competition allows groups of young people from each of the G8 countries to have their voices heard on a global stage--the annual G8 summit. An international essay competition results in the selection of teams of students who travel to the G8 summit to provide a youth perspective on global issues. The 2006 competition focused on four…

  3. Junior G8 Summit: Speaking Out with a "Passion for Peace"

    ERIC Educational Resources Information Center

    Education Canada, 2007

    2007-01-01

    The Junior G8 competition allows groups of young people from each of the G8 countries to have their voices heard on a global stage--the annual G8 summit. An international essay competition results in the selection of teams of students who travel to the G8 summit to provide a youth perspective on global issues. The 2006 competition focused on four…

  4. G8 and strengthening of health systems: follow-up to the Toyako summit.

    PubMed

    Reich, Michael R; Takemi, Keizo

    2009-02-07

    The 2008 G8 summit in Toyako, Japan, produced a strong commitment for collective action to strengthen health systems in developing countries, indicating Japan's leadership on, and the G8's increasing engagement with, global health policy. This paper describes the context for the G8's role in global health architecture and analyses three key components-financing, information, and the health workforce-that affect the performance of health systems. We propose recommendations for actions by G8 leaders to strengthen health systems by making the most effective use of existing resources and increasing available resources. We recommend increased attention by G8 leaders to country capacity and country ownership in policy making and implementation. The G8 should also implement a yearly review for actions in this area, so that changes in health-system performance can be monitored and better understood.

  5. Meeting Report: Outcomes from the Undergraduate Research Summit

    ERIC Educational Resources Information Center

    Wenzel, Thomas J.

    2004-01-01

    This article reports the outcomes from the undergraduate research summit held on August 2003 at Bates College in Lewiston, Maine. This summit brought together an array of stakeholders from the chemistry community, ranging from those with a long history of success in undergraduate research to junior faculty members who have started on a trajectory…

  6. Meeting Report: Outcomes from the Undergraduate Research Summit

    ERIC Educational Resources Information Center

    Wenzel, Thomas J.

    2004-01-01

    This article reports the outcomes from the undergraduate research summit held on August 2003 at Bates College in Lewiston, Maine. This summit brought together an array of stakeholders from the chemistry community, ranging from those with a long history of success in undergraduate research to junior faculty members who have started on a trajectory…

  7. Industry and Government Officials Meet for Space Weather Summit

    NASA Astrophysics Data System (ADS)

    Intriligator, Devrie S.

    2008-10-01

    Commercial airlines, electric power grids, cell phones, handheld Global Positioning Systems: Although the Sun is less active due to solar minimum, the number and types of situations and technologies that can benefit from up-to-date space weather information are growing. To address this, the second annual summit of the Commercial Space Weather Interest Group (CSWIG) and the National Oceanic and Atmospheric Administration's Space Weather Prediction Center (SWPC) was held on 1 May 2008 during Space Weather Workshop (SWW), in Boulder, Colo.

  8. Summary of summit meeting of professional society presidents and/or executive directors

    SciTech Connect

    Not Available

    1987-04-01

    This paper discusses the second Summit Meeting of presidents and executive officers of earth sciences societies. The meeting was held on February 6, 1987, in Washington, D.C., under the aegis of the Board on Earth Sciences (BES), National Research Council (NRC). The purpose the meeting is to improve coordination among the solid-earth sciences so that they will be better able to serve national needs. In addition to meetings such as this, the Board provides briefings for decision makers, including congressmen and their staffs, on current issues of solid-earth sciences, such as seismic hazards, global geoscience initiatives, volcanic eruptions, and the like.

  9. International Pediatric MS Study Group Clinical Trials Summit: meeting report.

    PubMed

    Chitnis, Tanuja; Tardieu, Marc; Amato, Maria Pia; Banwell, Brenda; Bar-Or, Amit; Ghezzi, Angelo; Kornberg, Andrew; Krupp, Lauren B; Pohl, Daniela; Rostasy, Kevin; Tenembaum, Silvia; Waubant, Emmanuelle; Wassmer, Evangeline

    2013-03-19

    Pediatric studies for new biological agents are mandated by recent legislation, necessitating careful thought to evaluation of emerging multiple sclerosis (MS) therapies in children with MS. Challenges include a small patient population, the lack of prior randomized clinical trials, and ethical concerns. The goal of this meeting was to assess areas of consensus regarding clinical trial design and outcome measures among academic experts involved in pediatric MS care and research. The Steering Committee of the International Pediatric MS Study Group identified key focus areas for discussion. A total of 69 meeting attendees were assembled, including 35 academic experts. Regulatory and pharmaceutical representatives also attended, and provided input, which informed academic expert consensus decisions. The academic experts agreed that clinical trials were necessary in pediatric MS to obtain pharmacokinetic, safety and efficacy data, and regulatory approval allowing for greater medication access. The academic experts agreed that relapse was an appropriate primary outcome measure for phase III pediatric trials. An international standardized cognitive battery was identified. The pros and cons of various trial designs were discussed. Guidelines surrounding MRI studies, pharmacokinetics, pharmacodynamics, and registries were developed. The academic experts agreed that given the limited subject pool, a stepwise approach to the launch of clinical trials for the most promising medications is necessary in order to ensure study completion. Alternative approaches could result in unethical exposure of patients to trial conditions without gaining knowledge. Consensus points for conduct of clinical trials in the rare disease pediatric MS were identified amongst a panel of academic experts, informed by regulatory and industry stakeholders.

  10. The Physical Therapy and Society Summit (PASS) Meeting: observations and opportunities.

    PubMed

    Kigin, Colleen M; Rodgers, Mary M; Wolf, Steven L

    2010-11-01

    The construct of delivering high-quality and cost-effective health care is in flux, and the profession must strategically plan how to meet the needs of society. In 2006, the House of Delegates of the American Physical Therapy Association passed a motion to convene a summit on "how physical therapists can meet current, evolving, and future societal health care needs." The Physical Therapy and Society Summit (PASS) meeting on February 27-28, 2009, in Leesburg, Virginia, sent a clear message that for physical therapists to be effective and thrive in the health care environment of the future, a paradigm shift is required. During the PASS meeting, participants reframed our traditional focus on the physical therapist and the patient/client (consumer) to one in which physical therapists are an integral part of a collaborative, multidisciplinary health care team with the health care consumer as its focus. The PASS Steering Committee recognized that some of the opportunities that surfaced during the PASS meeting may be disruptive or may not be within the profession's present strategic or tactical plans. Thus, adopting a framework that helps to establish the need for change that is provocative and potentially disruptive to our present care delivery, yet prioritizes opportunities, is a critical and essential step. Each of us in the physical therapy profession must take on post-PASS roles and responsibilities to accomplish the systemic change that is so intimately intertwined with our destiny. This article offers a perspective of the dynamic dialogue and suggestions that emerged from the PASS event, providing further opportunities for discussion and action within our profession.

  11. Identifying Practical Solutions to Meet America’s Fiber Needs: Proceedings from the Food & Fiber Summit

    PubMed Central

    Mobley, Amy R.; Jones, Julie Miller; Rodriguez, Judith; Slavin, Joanne; Zelman, Kathleen M.

    2014-01-01

    Fiber continues to be singled out as a nutrient of public health concern. Adequate intakes of fiber are associated with reduced risk for cardiovascular disease, cancer, diabetes, certain gastrointestinal disorders and obesity. Despite ongoing efforts to promote adequate fiber through increased vegetable, fruit and whole-grain intakes, average fiber consumption has remained flat at approximately half of the recommended daily amounts. Research indicates that consumers report increasingly attempting to add fiber-containing foods, but there is confusion around fiber in whole grains. The persistent and alarmingly low intakes of fiber prompted the “Food & Fiber Summit,” which assembled nutrition researchers, educators and communicators to explore fiber’s role in public health, current fiber consumption trends and consumer awareness data with the objective of generating opportunities and solutions to help close the fiber gap. The summit outcomes highlight the need to address consumer confusion and improve the understanding of sources of fiber, to recognize the benefits of various types of fibers and to influence future dietary guidance to provide prominence and clarity around meeting daily fiber recommendations through a variety of foods and fiber types. Potential opportunities to increase fiber intake were identified, with emphasis on meal occasions and food categories that offer practical solutions for closing the fiber gap. PMID:25006857

  12. Identifying practical solutions to meet America's fiber needs: proceedings from the Food & Fiber Summit.

    PubMed

    Mobley, Amy R; Jones, Julie Miller; Rodriguez, Judith; Slavin, Joanne; Zelman, Kathleen M

    2014-07-08

    Fiber continues to be singled out as a nutrient of public health concern. Adequate intakes of fiber are associated with reduced risk for cardiovascular disease, cancer, diabetes, certain gastrointestinal disorders and obesity. Despite ongoing efforts to promote adequate fiber through increased vegetable, fruit and whole-grain intakes, average fiber consumption has remained flat at approximately half of the recommended daily amounts. Research indicates that consumers report increasingly attempting to add fiber-containing foods, but there is confusion around fiber in whole grains. The persistent and alarmingly low intakes of fiber prompted the "Food & Fiber Summit," which assembled nutrition researchers, educators and communicators to explore fiber's role in public health, current fiber consumption trends and consumer awareness data with the objective of generating opportunities and solutions to help close the fiber gap. The summit outcomes highlight the need to address consumer confusion and improve the understanding of sources of fiber, to recognize the benefits of various types of fibers and to influence future dietary guidance to provide prominence and clarity around meeting daily fiber recommendations through a variety of foods and fiber types. Potential opportunities to increase fiber intake were identified, with emphasis on meal occasions and food categories that offer practical solutions for closing the fiber gap.

  13. We the Children: Meeting the Promises of the World Summit for Children.

    ERIC Educational Resources Information Center

    Annan, Kofi A.

    This abridged version of the Secretary-General's report to the United Nations General Assembly's Special Session on Children details the achievements of the 1990 World Summit for Children. Nearly 150 countries provided national progress reports of their implementation of goals set forth in the Summit and the 1989 Convention on the Rights of the…

  14. We the Children: Meeting the Promises of the World Summit for Children.

    ERIC Educational Resources Information Center

    Annan, Kofi A.

    This abridged version of the Secretary-General's report to the United Nations General Assembly's Special Session on Children details the achievements of the 1990 World Summit for Children. Nearly 150 countries provided national progress reports of their implementation of goals set forth in the Summit and the 1989 Convention on the Rights of the…

  15. The Future of Sleep Technology: Report from an American Association of Sleep Technologists Summit Meeting

    PubMed Central

    Brooks, Rita; Trimble, Melinda

    2014-01-01

    integrated care will include an increased focus on patient education, monitoring, and follow-up. The most effective treatments will require an individualized, patient-centered approach. A workforce analysis shows that the number of trained physician specialists will be inadequate to provide this care. Well-trained sleep medicine practitioners at many levels will be needed to meet treatment goals, including some roles appropriate for sleep technologists. These factors provide challenges and opportunities for sleep technologists. In order to maintain viability as an allied health profession, the majority of sleep technologists will need to be better educated and demonstrate competency in more roles than overnight monitoring and record scoring. Models for this transition already exist, with several programs moving technologists from night work to days and from diagnosis to patient education, provision of treatment, and monitoring of adherence. The challenge for the professional association is to define new roles for sleep technologists and provide the education that the membership will require to flourish in those new roles. Citation: Brooks R, Trimble M. The future of sleep technology: report from an American Association of Sleep Technologists summit meeting. J Clin Sleep Med 2014;10(5):589-593. PMID:24812546

  16. The G8 and global health: What now? What next?

    PubMed

    Labonte, Ronald; Schrecker, Ted

    2006-01-01

    The policies of the G8 countries (the G7 industrialized countries plus Russia) matter for population health and the determinants of health worldwide. In the years before the 2005 Summit, relevant G7 commitments were more often broken than kept, representing an inadequate response to the scale of health crises in countries outside the industrialized world. The commitments made in 2005 by some G7 countries to increase development assistance to the longstanding target of 0.7% of Gross National Income, and by the G7 as a whole to additional debt cancellation for some developing countries, were welcome and overdue. However, Canada and the United States did not state timetables for reaching the development assistance target, and new conditionalities attached to debt relief may undermine the benefits for population health. Lack of adequate funding for the Global Fund to Fight AIDS, Tuberculosis and Malaria, even after the September 2005 replenishment meeting, is unconscionable; yet even if those funds were provided, additional resources for developing country health systems would be needed. Similarly, widespread agreement on the need for improving market access for developing country exports was not met with any concrete policy response to the "asymmetrical" nature of recent trade liberalization; neither was the need to control the deadly trade in small arms. To respond adequately to global health needs, the G8 will need to adopt an agenda that more fundamentally alters the distribution of economic and political power, within and among nations.

  17. Building a sustainable clinical academic workforce to meet the future healthcare needs of Australia and New Zealand: report from the first summit meeting.

    PubMed

    Windsor, J; Searle, J; Hanney, R; Chapman, A; Grigg, M; Choong, P; Mackay, A; Smithers, B M; Churchill, J A; Carney, S; Smith, J A; Wainer, Z; Talley, N J; Gladman, M A

    2015-09-01

    The delivery of healthcare that meets the requirements for quality, safety and cost-effectiveness relies on a well-trained medical workforce, including clinical academics whose career includes a specific commitment to research, education and/or leadership. In 2011, the Medical Deans of Australia and New Zealand published a review on the clinical academic workforce and recommended the development of an integrated training pathway for clinical academics. A bi-national Summit on Clinical Academic Training was recently convened to bring together all relevant stakeholders to determine how best to do this. An important part understood the lessons learnt from the UK experience after 10 years since the introduction of an integrated training pathway. The outcome of the summit was to endorse strongly the recommendations of the medical deans. A steering committee has been established to identify further stakeholders, solicit more information from stakeholder organisations, convene a follow-up summit meeting in late 2015, recruit pilot host institutions and engage the government and future funders.

  18. The future of sleep technology: report from an American Association of Sleep Technologists summit meeting.

    PubMed

    Brooks, Rita; Trimble, Melinda

    2014-05-15

    The American Association of Sleep Technologists (AAST) Board of Directors hosted a Sleep Technology Summit on September 21, 2013 with the goals of identifying changes in the delivery of diagnostic and treatment services to sleep disorders patients, predicting the impact on sleep technologists, identifying new roles for sleep technologists, and determining appropriate education to prepare technologists for the future. A carefully chosen panel of speakers focused on the business skills necessary to provide care cost effectively and the clinical skills that will be essential for the technologist of the future to help care for patients with sleep disorders. A group of selected leaders, educators, and industry professionals reviewed the current state of affairs and examined opportunities to sustain the profession and define the role of the sleep technologist of the future. Facilitated group discussions of these critical topics followed each session. There was a clear consensus that regulatory and economic pressures are changing the way sleep disorders patients are diagnosed and treated. Private insurers are requiring pre-authorization for laboratory sleep studies and are incentivizing home sleep testing for most patients suspected of obstructive sleep apnea. Reimbursement for home testing will be lower than for laboratory testing, and further reductions in overall reimbursement are anticipated. These factors will almost certainly reduce the need for technologists to perform laboratory diagnostic studies and pressure sleep centers to reduce payrolls. Remaining laboratory patients will have more complicated sleep disorders, have more comorbidity, and require a higher level of care than most of the patients currently tested in sleep centers. Testing these patients will require technologists with a higher level of training, experience, and sophistication. A second area of consensus was that the focus in medicine is changing from diagnosis to outcomes. New models of

  19. The political process in global health and nutrition governance: the G8's 2010 Muskoka Initiative on Maternal, Child, and Newborn Health.

    PubMed

    Kirton, John; Kulik, Julia; Bracht, Caroline

    2014-12-01

    Why do informal, plurilateral summit institutions such as the Group of Eight (G8) major market democracies succeed in advancing costly public health priorities such as maternal, newborn, and child health (MNCH), even when the formal, multilateral United Nations (UN) system fails to meet such goals, when G8 governments afflicted by recession, deficit, and debt seek to cut expenditures, and when the private sector is largely uninvolved, despite the growing popularity of public-private partnerships to meet global health and related nutrition, food, and agriculture needs? Guided by the concert-equality model of G8 governance, this case study of the G8's 2010 Muskoka Initiative on MNCH traces the process through which that initiative was planned within Canada, internationally prepared through negotiations with Canada's G8 partners, produced at Muskoka by the leaders in June, multiplied in its results by the UN summit in September, and reinforced by the new accountability mechanism put in place. It finds that the Muskoka summit succeeded in mobilizing major money and momentum for MNCH. This was due to the initiative and influence of children-focused nongovernmental organizations (NGOs), working with committed individuals and agencies within the host Canadian government, as well as supportive public opinion and the help of those in the UN responsible for realizing its Millennium Development Goals. Also relevant were the democratic like-mindedness of G8 leaders and their African partners, the deference of G8 members to the host's priority, and the need of the G8 to demonstrate its relevance through a division of labor between it and the new Group of Twenty summit. This study shows that G8 summits can succeed in advancing key global health issues without a global shock on the same subject to galvanize agreement and action. It suggests that, when committed, focused NGOs and government officials will lead and the private sector will follow, but that there will be a lag in the

  20. Summary of summit meeting of professional society presidents and/or executive directors

    SciTech Connect

    Not Available

    1986-04-01

    The Board on Earth Sciences convened a meeting of presidents and executive directors of major American solid earth sciences professional organizations on February 7, 1986, to explore the commonalities of goals and to enhance the effectiveness of individuals and organizations. The following items were discussed by leaders in the earth sciences: responsibilities of the Board on Earth Sciences and the American Geological Institute; new scientific initiatives in the solid earth sciences; the 1989 International Geological Congress; the International Geosphere-Biosphere Program; the International Decade of Hazard Reduction; the deteriorating situation in the American energy and mineral resources industries; the state of geological mapping in the United States; and funding for research in the solid earth sciences. Policy statements were developed on several of the above topics. Problem areas were identified that require the continuing attention of the earth sciences community. The problem areas enumerated during the meeting are presented in summary in the text. 3 figs.

  1. TB Summit 2014: prevention, diagnosis, and treatment of tuberculosis-a meeting report of a Euroscicon conference.

    PubMed

    Maitra, Arundhati; Bhakta, Sanjib

    2014-07-01

    World TB Day commemorates Dr Robert Koch's first announcement on March 24, 1882, that the bacterium Mycobacterium tuberculosis is the causative agent of tuberculosis. Currently, the event comprises of several conferences, meetings and activities held all over the world with the singular intention of raising public awareness about the global health emergency. In spite of having discovered the etiological agent of tuberculosis more than a century ago, a sizeable population still contract the disease every year and fall prey to it. In 2012, an estimated 8.6 million people developed the disease with 1.3 million succumbing to it. The number of TB deaths in children is unacceptably large, given that most are preventable. However, the challenge appears to be shifting toward attempts to control the rise and spread of the drug resistant variants of the microbe. To achieve this, a concerted effort from academia, clinical practice, and industry has been put forth. The TB Summit 2014 attempted to raise awareness as well as bring together experts involved in different aspects of tuberculosis research to help establish a more collective approach to battle this age-old disease.

  2. From Port-of-Spain summit to United Nations High Level Meeting CARICOM and the global non-communicable disease agenda.

    PubMed

    Samuels, T A; Hospedales, C J

    2011-07-01

    The English-speaking Caribbean has the highest per capita burden of chronic non-communicable diseases (CNCDs) in the region of the Americas. Building on a long history of cooperation in health among the Caribbean Community (CARICOM) and past successes in eliminating/reducing communicable diseases through collective action, non-communicable diseases (NCDs) have now been targeted CARICOM convened a "first-in-the-world" summit of Heads of Government to address NCDs, which generated the Port-of-Spain NCD Summit Declaration, "Uniting to Stop The Epidemic of Chronic Noncommunicable Diseases". This 15-point declaration calls on all of government, civil society and the private sector to jointly tackle the common risk factors for the major chronic diseases, and improve the care of such diseases. Implementation of this declaration has been mixed, being most successful where there were regional supports, and in countries with populations > 250 000 reflecting country capacity. CARICOM has elevated this approach to the global level through successful advocacy for a United Nations High Level Meeting on NCDs to be convened in September 2011. Jamaica will be one of two co-facilitators of this meeting, a reflection of the role of CARICOM countries in advancing the NCD agenda at the global level. CARICOM Heads of Government should attend this meeting, showcase the implementation of the NCD Summit Declaration in the Caribbean, commit to enhancing systems and resources, endorse and implement the commitments made and identify and support leadership for sustained action and accountability for these initiatives.

  3. 2007 Youth Policy Summit Summary

    ERIC Educational Resources Information Center

    Reid, Ellen; Fussell, Annemarie; Templin, Elizabeth

    2007-01-01

    The NCSSSMST (National Consortium for Specialized Secondary Schools of Mathematics, Science and Technology) and Keystone Science School co-sponsored two Youth Policy Summits during the summer of 2007. Forty students represented 10 high schools from across the country at each Summit, meeting for a week in June and August at Keystone Science School…

  4. Summing up the Summit

    ERIC Educational Resources Information Center

    Richards, Jan

    2009-01-01

    The President of ALIA writes about expectations for the Public Libraries Summit, and provides an account of what took place on the day of the meeting, and what has taken place since. In funding terms, the most likely areas of productive engagement with the federal government are considered to be: children, early learning and a literate Australia;…

  5. Summing up the Summit

    ERIC Educational Resources Information Center

    Richards, Jan

    2009-01-01

    The President of ALIA writes about expectations for the Public Libraries Summit, and provides an account of what took place on the day of the meeting, and what has taken place since. In funding terms, the most likely areas of productive engagement with the federal government are considered to be: children, early learning and a literate Australia;…

  6. The Immunotherapeutics and Vaccine Summit - CHI's fifth annual meeting - novel vaccines: adjuvants and delivery systems: part 2.

    PubMed

    Jones, Susan D

    2010-10-01

    The Fifth Annual Immunotherapeutics and Vaccine Summit (ImVacS), held in Boston, included topics covering new developments in the field of adjuvants and delivery systems for vaccines. This conference report highlights selected presentations on vaccines for infectious diseases, the use of adenovirus 5 (Ad5) for oral vaccination, modes of delivery for vaccines, and the strategy of DNA vaccination.

  7. MEETING REPORT: UNESCO-MERCK AFRICA RESEARCH SUMMIT 2015- ACCELERATING ACCESS AND SUSTAINING INNOVATION ‘FROM AFRICA FOR AFRICA’

    PubMed Central

    Omange, R.W.; Ocholla, A.O.; Kwallah., A.O; Kageha, S. N.; Mwangi, J.; Cherutich, R. K; T.A., Odeny.; Nzomo, T.; Angwenyi, S.; Yonga., P; Kariuki, F.; Kyalo, M.; Mutai, P.C.; Nindo, F.; Songok, E.M

    2017-01-01

    Background: The Ebola virus disease outbreak of 2014 was the largest, longest and most devastating in the history of the disease. It demonstrated the social and economic impact an emerging infectious disease can have in a globalized world. Health systems in affected countries were stretched to the point of near collapse, while social relations and traditional practices were negatively impacted. Heads of African research institutions, African government representatives, leaders of global pharmaceutical companies, global infectious disease experts and close to 100 young African researchers from 25 countries; Assembled in Geneva on 19 and 20th October 2015, for the inaugural UNESCO-Merck Africa Summit sponsored by the United Nations Educational, Science and Culture Organization and Merck KGA Goal of Summit: The primary goal of the summit was to develop strategies to increase health research capacity in Africa, with special focus on Ebola and enhancing pandemic preparation for emerging infectious diseases. The summit was also provide a forum to showcase the research taking place in Africa, and provided platform for African researchers to network. Some of the key issues discussed included; strategies for enhancing policy frameworks to promote knowledge translation, strengthening of health systems, enhancing knowledge and data sharing, and increasing innovation in Africa. Conclusions: Summit attendees recognized that Africa still bore the heaviest burden of infectious disease, and increased commitment by African governments to fund health research, offered the best hope for developing health solutions and interventions to improve the health of Africans. Improved health in turn would enhance the productivity of Africans, further supporting the socio-economic transformation currently taking place on the continent. PMID:28337491

  8. Elysium Summit

    NASA Technical Reports Server (NTRS)

    2006-01-01

    5 February 2006 This Mars Global Surveyor (MGS) Mars Orbiter Camera (MOC) image shows a channel extending northward from the Elysium Mons caldera at the volcano's summit. The north wall of the caldera -- the summit depression formed by collapse as magma withdraws, is located at the south end (bottom) of this picture.

    Location near: 24.8oN, 213.3oW Image width: 3 km (1.9 mi) Illumination from: lower left Season: Northern Autumn

  9. 77 FR 13232 - Security Zones; G8/North Atlantic Treaty Organization (NATO) Summit, Chicago, IL

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-06

    .... Department of Transportation, West Building Ground Floor, Room W12-140, 1200 New Jersey Avenue SE...'' in the ``Actions'' column. You may also visit the Docket Management Facility in Room W12-140 on the... security zones is necessary to mitigate the threat of violence and ensure the safety and security of those...

  10. Summit surprises.

    PubMed

    Myers, N

    1994-01-01

    A New Delhi Population Summit, organized by the Royal Society, the US National Academy of Sciences, the Royal Swedish Academy of Sciences, and the Indian National Science Academy, was convened with representation of 120 (only 10% women) scientists from 50 countries and about 12 disciplines and 43 national scientific academies. Despite the common assumption that scientists never agree, a 3000 word statement was signed by 50 prominent national figures and supported by 25 professional papers on diverse subjects. The statement proclaimed that stable world population and "prodigious planning efforts" are required for dealing with global social, economic, and environmental problems. The target should be zero population growth by the next generation. The statement, although containing many uncompromising assertions, was not as strong as a statement by the Royal Society and the US National Academy of Sciences released last year: that, in the future, science and technology may not be able to prevent "irreversible degradation of the environment and continued poverty," and that the capacity to sustain life on the planet may be permanently jeopardized. The Delhi statement was backed by professional papers highlighting several important issues. Dr Mahmoud Fathalla of the Rockefeller Foundation claimed that the 500,000 annual maternal deaths worldwide, of which perhaps 33% are due to "coathanger" abortions, are given far less attention than a one-day political event of 500 deaths would receive. Although biologically women have been given a greater survival advantage, which is associated with their reproductive capacity, socially disadvantaged females are relegated to low status. There is poorer nutrition and overall health care for females, female infanticide, and female fetuses are increasingly aborted in China, India, and other countries. The sex ratio in developed countries is 95-97 males to every 100 females, but in developing Asian countries the ratio is 105 males to 100

  11. Operational and Research Musculoskeletal Summit: Summit Recommendations

    NASA Technical Reports Server (NTRS)

    Scheuring, Richard A.; Walton, Marlei; Davis-Street, Janis; Smaka, Todd J.; Griffin, DeVon

    2006-01-01

    The Medical Informatics and Health Care Systems group in the Office of Space Medicine at NASA Johnson Space Center (JSC) has been tasked by NASA with improving overall medical care on the International Space Station (ISS) and providing insights for medical care for future exploration missions. To accomplish this task, a three day Operational and Research Musculoskeletal Summit was held on August 23-25th, 2005 at Space Center Houston. The purpose of the summit was to review NASA#s a) current strategy for preflight health maintenance and injury screening, b) current treatment methods in-flight, and c) risk mitigation strategy for musculoskeletal injuries or syndromes that could occur or impact the mission. Additionally, summit participants provided a list of research topics NASA should consider to mitigate risks to astronaut health. Prior to the summit, participants participated in a web-based pre-summit forum to review the NASA Space Medical Conditions List (SMCL) of musculoskeletal conditions that may occur on ISS as well as the resources currently available to treat them. Data from the participants were compiled and integrated with the summit proceedings. Summit participants included experts from the extramural physician and researcher communities, and representatives from NASA Headquarters, the astronaut corps, JSC Medical Operations and Human Adaptations and Countermeasures Offices, Glenn Research Center Human Research Office, and the Astronaut Strength, Conditioning, and Reconditioning (ASCR) group. The recommendations in this document are based on a summary of summit discussions and the best possible evidence-based recommendations for musculoskeletal care for astronauts while on the ISS, and include recommendati ons for exploration class missions.

  12. 16 CFR Appendix G8 to Part 305 - Boilers (Electric)

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 16 Commercial Practices 1 2014-01-01 2014-01-01 false Boilers (Electric) G8 Appendix G8 to Part... LABELING RULEâ) Appendix G8 to Part 305—Boilers (Electric) Type Range of annual fuel utilization efficiencies (AFUEs) Low High Electric Boilers 100 100...

  13. New Visions in Action: National Assessment Summit Papers

    ERIC Educational Resources Information Center

    Rosenbusch, Marcia Harmon, Ed.

    2006-01-01

    The National Assessment Summit was designed to bring together users and producers of assessments and engage them in a discussion of unmet assessment needs and untapped assessment capacities. The meeting was truly a summit in that national foreign language organizations and associations were asked to nominate representatives to bring their…

  14. Atrial Arrhythmia Summit: Post Summit Report

    NASA Technical Reports Server (NTRS)

    Barr, Yael

    2010-01-01

    The Atrial Arrhythmia Summit brought together nationally and internationally recognized experts in cardiology, electrophysiology, exercise physiology, and space medicine in an effort to elucidate the mechanisms, risk factors, and management of atrial arrhythmias in the unique occupational cohort of the U.S. astronaut corps.

  15. Global warming at the summit

    NASA Astrophysics Data System (ADS)

    Showstack, Randy

    During the recent summit meeting between Russian President Vladimir Putin and U.S. President Bill Clinton, the two leaders reaffirmed their concerns about global warming and the need to continue to take actions to try to reduce the threat.In a June 4 joint statement, they stressed the need to develop flexibility mechanisms, including international emissions trading, under the Kyoto Protocol to the United Nations Framework Convention on Climate Change. They also noted that initiatives to reduce the risk of greenhouse warming, including specific mechanisms of the Kyoto Protocol, could potentially promote economic growth.

  16. The Immunotherapeutics & Vaccine Summit--CHI's fourth annual meeting. Preclinical/clinical development of immunotherapies and vaccines. 17-19 August 2009, Providence, RI, USA.

    PubMed

    Butterfield, Lisa H

    2009-10-01

    The Immunotherapeutics & Vaccine Summit held in Providence, RI, USA included topics covering new preclinical and clinical developments in the field of immunotherapies and vaccines. This conference report highlights selected presentations on the iSBTc-FDA-NCI taskforce findings on immunotherapy biomarkers, clinical assay development and optimization, and bioassays to measure immune responses. Investigational vaccines discussed include a fusion protein adjuvant vaccine (Research by Discovery), a novel intradermal particle delivery device (Université de Sherbrooke) and a Hsp-based vaccine for meningitis (ImmunoBiology Ltd).

  17. International Summit on Integrated Environmental Modeling

    EPA Science Inventory

    This report describes the International Summit on Integrated Environmental Modeling (IEM), held in Washington, DC 7th-9th December 2010. The meeting brought together 57 scientists and managers from leading US and European government and non-governmental organizations, universitie...

  18. International Summit on Integrated Environmental Modeling

    EPA Science Inventory

    This report describes the International Summit on Integrated Environmental Modeling (IEM), held in Washington, DC 7th-9th December 2010. The meeting brought together 57 scientists and managers from leading US and European government and non-governmental organizations, universitie...

  19. NASA Education Stakeholder's Summit

    NASA Image and Video Library

    2010-09-12

    NASA Administrator Charles Bolden gives keynote remarks at the NASA Education Stakeholders’ Summit One Stop Shopping Initiative (OSSI), Monday, Sep. 13, 2010, at the Westfields Marriott Conference Center in Chantilly, VA. (Photo Credit: NASA/Carla Cioffi)

  20. Announcing Supercomputer Summit

    ScienceCinema

    Wells, Jack; Bland, Buddy; Nichols, Jeff; Hack, Jim; Foertter, Fernanda; Hagen, Gaute; Maier, Thomas; Ashfaq, Moetasim; Messer, Bronson; Parete-Koon, Suzanne

    2016-07-12

    Summit is the next leap in leadership-class computing systems for open science. With Summit we will be able to address, with greater complexity and higher fidelity, questions concerning who we are, our place on earth, and in our universe. Summit will deliver more than five times the computational performance of Titan’s 18,688 nodes, using only approximately 3,400 nodes when it arrives in 2017. Like Titan, Summit will have a hybrid architecture, and each node will contain multiple IBM POWER9 CPUs and NVIDIA Volta GPUs all connected together with NVIDIA’s high-speed NVLink. Each node will have over half a terabyte of coherent memory (high bandwidth memory + DDR4) addressable by all CPUs and GPUs plus 800GB of non-volatile RAM that can be used as a burst buffer or as extended memory. To provide a high rate of I/O throughput, the nodes will be connected in a non-blocking fat-tree using a dual-rail Mellanox EDR InfiniBand interconnect. Upon completion, Summit will allow researchers in all fields of science unprecedented access to solving some of the world’s most pressing challenges.

  1. Announcing Supercomputer Summit

    SciTech Connect

    Wells, Jack; Bland, Buddy; Nichols, Jeff; Hack, Jim; Foertter, Fernanda; Hagen, Gaute; Maier, Thomas; Ashfaq, Moetasim; Messer, Bronson; Parete-Koon, Suzanne

    2016-06-28

    Summit is the next leap in leadership-class computing systems for open science. With Summit we will be able to address, with greater complexity and higher fidelity, questions concerning who we are, our place on earth, and in our universe. Summit will deliver more than five times the computational performance of Titan’s 18,688 nodes, using only approximately 3,400 nodes when it arrives in 2017. Like Titan, Summit will have a hybrid architecture, and each node will contain multiple IBM POWER9 CPUs and NVIDIA Volta GPUs all connected together with NVIDIA’s high-speed NVLink. Each node will have over half a terabyte of coherent memory (high bandwidth memory + DDR4) addressable by all CPUs and GPUs plus 800GB of non-volatile RAM that can be used as a burst buffer or as extended memory. To provide a high rate of I/O throughput, the nodes will be connected in a non-blocking fat-tree using a dual-rail Mellanox EDR InfiniBand interconnect. Upon completion, Summit will allow researchers in all fields of science unprecedented access to solving some of the world’s most pressing challenges.

  2. International summit on integrated environmental modeling

    USGS Publications Warehouse

    Gaber, Noha; Geller, Gary; Glynn, Pierre; Laniak, Gerry; Voinov, Alexey; Whelan, Gene; Roger, Moore; Hughes, Andrew

    2013-01-01

    This report describes the International Summit on Integrated Environmental Modeling (IEM), held in Reston, VA, on 7th-9th December 2010. The meeting brought together 57 scientists and managers from leading US and European government and non-governmental organizations, universities and companies together with international organizations convened over a number of years, including: the US Environmental Protection Agency (USEPA) workshop on Collaborative Approaches to Integrated Modeling: Better Integration for Better Decisionmaking (December, 2008); the AGU Fall Meeting, San Francisco (December 2009); and the International Congress on Environmental Modeling and Software (July 2010). From these meetings there is now recognition that many separate communities are involved in developing IEM. The aim of the Summit was to bring together two key groupings, the US and Europe, with the intention of creating a community open to all.

  3. It's a long way to Auchterarder! 'Negotiated management' and mismanagement in the policing of G8 protests.

    PubMed

    Gorringe, Hugo; Rosie, Michael

    2008-06-01

    Recent analyses of protest policing in Western democracies argue that there has been a marked shift away from oppressive or coercive approaches to an emphasis on consensus based negotiation. King and Waddington (2005) amongst others, however, suggest that the policing of international summits may be an exception to this rule. This paper examines protest policing in relation to the 2005 G8 summit in Gleneagles, Scotland. We argue that 'negotiated management' cannot be imported wholesale as a policing strategy. Rather it is mediated by local history, forms of police knowledge and modes of engagement. Drawing on interviews and participant observation we show that 'negotiated management' works best when both sides are committed to negotiation and that police stereotyping or protestor intransigence can lead to the escalation of any given event. In closing we note the new challenges posed by forms of 'global' protest and consider the implications for future policing of protest.

  4. PACIFIC NORTHWEST CYBER SUMMIT

    SciTech Connect

    Lesperance, Ann M.; Matlock, Gordon W.; Becker-Dippmann, Angela S.; Smith, Karen S.

    2013-08-07

    On March 26, 2013, the Snohomish County Public Utility District (PUD) and the U.S. Department of Energy’s (DOE’s) Pacific Northwest National Laboratory (PNNL) jointly hosted the Pacific Northwest Cyber Summit with the DOE’s Office of Electricity Delivery and Energy Reliability, the White House, Washington State congressional delegation, Washington State National Guard, and regional energy companies.

  5. NASA Education Stakeholder's Summit

    NASA Image and Video Library

    2010-09-12

    William Kelly, PhD, PE, Manager, Public Affairs, American Society for Engineering Education speaks at the NASA Education Stakeholders’ Summit One Stop Shopping Initiative (OSSI), Monday, Sep. 13, 2010, at the Westfields Marriott Conference Center in Chantilly, VA. Seated are NASA Administrator Charles Bolden, left, and NASA Acting Associate Administrator for Education, James Stofan. (Photo Credit: NASA/Carla Cioffi)

  6. Simulating Global Climate Summits

    ERIC Educational Resources Information Center

    Vesperman, Dean P.; Haste, Turtle; Alrivy, Stéphane

    2014-01-01

    One of the most persistent and controversial issues facing the global community is climate change. With the creation of the UN Framework Convention on Climate Change (UNFCCC) in 1992 and the Kyoto Protocol (1997), the global community established some common ground on how to address this issue. However, the last several climate summits have failed…

  7. NASA Education Stakeholder's Summit

    NASA Image and Video Library

    2010-09-12

    Cora B. Marrett, PhD, Acting Director, National Science Foundation gives keynote remarks at the NASA Education Stakeholders’ Summit One Stop Shopping Initiative (OSSI), Monday, Sep. 13, 2010, at the Westfields Marriott Conference Center in Chantilly, VA. (Photo Credit: NASA/Carla Cioffi)

  8. NASA Education Stakeholder's Summit

    NASA Image and Video Library

    2010-09-12

    Leland Melvin, right, Education Design Team Co-Chair and NASA Astronaut, speaks at the NASA Education Stakeholders’ Summit One Stop Shopping Initiative (OSSI), Monday, Sep. 13, 2010, at the Westfields Marriott Conference Center in Chantilly, VA. (Photo Credit: NASA/Carla Cioffi)

  9. NASA Education Stakeholder's Summit

    NASA Image and Video Library

    2010-09-12

    Cora B. Marrett, right, PhD, Acting Director, National Science Foundation gives keynote remarks at the NASA Education Stakeholders’ Summit One Stop Shopping Initiative (OSSI), Monday, Sep. 13, 2010, at the Westfields Marriott Conference Center in Chantilly, VA. (Photo Credit: NASA/Carla Cioffi)

  10. NASA Education Stakeholder's Summit

    NASA Image and Video Library

    2010-09-12

    Marion C. Blakey, President and CEO, Aerospace Industries Association, addresses guests at the NASA Education Stakeholders’ Summit One Stop Shopping Initiative (OSSI), Monday, Sep. 13, 2010, at the Westfields Marriott Conference Center in Chantilly, VA. (Photo Credit: NASA/Carla Cioffi)

  11. NASA Education Stakeholder's Summit

    NASA Image and Video Library

    2010-09-12

    James Stofan, right, NASA Acting Associate Administrator for Education, introduces the keynote speakers at the NASA Education Stakeholders’ Summit One Stop Shopping Initiative (OSSI), Monday, Sep. 13, 2010, at the Westfields Marriott Conference Center in Chantilly, VA. (Photo Credit: NASA/Carla Cioffi)

  12. Simulating Global Climate Summits

    ERIC Educational Resources Information Center

    Vesperman, Dean P.; Haste, Turtle; Alrivy, Stéphane

    2014-01-01

    One of the most persistent and controversial issues facing the global community is climate change. With the creation of the UN Framework Convention on Climate Change (UNFCCC) in 1992 and the Kyoto Protocol (1997), the global community established some common ground on how to address this issue. However, the last several climate summits have failed…

  13. NASA Education Stakeholder's Summit

    NASA Image and Video Library

    2010-09-12

    Special Assitant for STEM Education, U. S. Department of Education, Michael Lach, far right, addresses guests at the NASA Education Stakeholders’ Summit One Stop Shopping Initiative (OSSI), Monday, Sep. 13, 2010, at the Westfields Marriott Conference Center in Chantilly, VA. Seated from right are James Stofan, NASA Acting Associate Administrator for Education; Charles Bolden, NASA Administrator; and Cora B. Marrett, Acting Director, National Science Foundation. (Photo Credit: NASA/Carla Cioffi)

  14. Ascraeus Mons Summit

    NASA Technical Reports Server (NTRS)

    2005-01-01

    7 March 2005 This Mars Global Surveyor (MGS) Mars Orbiter Camera (MOC) image shows a lava channel on the northeastern summit of Ascraeus Mons.

    Location near: 11.5oN, 104.2oW Image width: 3 km (1.9 mi) Illumination from: upper left Season: Northern Spring

  15. Dental education summits: the challenges ahead.

    PubMed

    Bailit, Howard; Weaver, Richard; Haden, Karl; Kotowicz, William; Hovland, Eric

    2003-08-01

    The authors present the major findings from ADA-sponsored education summit meetings in 2001 and 2002 that addressed the issues of dental education costs, dental student debt levels at graduation and budgeted unfilled dental school faculty positions. The meetings included representation from the ADA, the American Dental Education Association, the American Student Dental Association, the National Institute of Dental and Craniofacial Research and ADA-recognized dental specialty organizations. National experts on the three issue areas made formal presentations. State funds for dental education declined 22 percent from 1991 to 1998, after adjusting for inflation. Reductions in state budgets for 2002 and 2003 suggest further declines in state support. To cope with declining revenues, schools increased student tuition and fees 10 percent annually from 1991 to 1998, contributing to increasing levels of student educational debt, which in 2000 averaged dollar 87,600. Dental schools also have decreased their investment in physical plant and faculty numbers. Annual faculty salaries have increased 3 percent, while practitioner income has increased 7 percent. Academic income disparities with private practice have contributed to dental schools having almost 400 unfilled faculty positions. Dental education is facing severe financial challenges that likely will increase. While there are no easy solutions, schools must make greater efforts to reduce operating expenses and seek more state and federal support for dental education. The ADA approved the summit reports, and the ADA House of Delegates adopted six resolutions that support the summits' recommendations.

  16. Summiteers--Moving Mountains with Bereaved Boys

    ERIC Educational Resources Information Center

    Renner, Hans-Georg

    2011-01-01

    Summiteers are people who rush to the top. There is a mountain summit and a metaphorical summit inside us which we can climb. In the area of mountain summits, Reinhold Messner is surely the best known and most successful summiteer. He climbed, among other things, the highest peak on earth without supplemental oxygen. In the language of the country…

  17. Summit Renovations, Inc. Information Sheet

    EPA Pesticide Factsheets

    Summit Renovations, Inc. (the Company) is located in Centennial, Colorado. The settlement involves renovation activities conducted at a property constructed prior to 1978, located in Denver, Colorado.

  18. The 2015 Pregnancy Summit, London, UK.

    PubMed

    Johansson, Cherynne

    2016-01-01

    Pregnancy Summit, Cineworld, The O2, London, UK, 29 September to 1 October 2015 The 2015 Pregnancy Summit was held over 3 days from 29 September to 1 October at Cineworld, The O2, London, UK. The event brings together a multidisciplinary faculty of international researchers and clinicians to discuss both scientific and clinical aspects of pregnancy-related issues in an informal setting. The goal of the meeting was to provide delegates with an update of recent advances in management of pregnancy-related conditions, to present research data and to discuss the current attitudes and practices in relevant topics. An extensive range of topics were discussed, from preeclampsia and treatment of hypertension, to the psychological impact of termination of pregnancy and feticide. This report will summarize a selection of the lectures presented.

  19. 2009 Munitions Executive Summit

    DTIC Science & Technology

    2009-02-05

    Munitions Executive Summit “Re- Shaping the Munitions Enterprise” New Orleans, LA February 3 - 5, 2009 Conference Agenda MONDAY, FEBRUARY 4, 2009 PEO...155mm Infrared Illuminating Projectile • USMC Urgent Need Spring’08 • In Theater by June’08 3 Industry Support • Industry Partnering – Mortar Primer...Conference 2009 1300 Wilson Boulevard, Suite 320 Arlington, VA 22209 (703) 504‐9300 pchao@rsadvisors.net FEBRUARY 5, 2009 RE‐ SHAPING  THE MUNITIONS

  20. NASA Education Stakeholder's Summit

    NASA Image and Video Library

    2010-09-12

    NASA Administrator Charles Bolden, far right, gives keynote remarks at the NASA Education Stakeholders’ Summit One Stop Shopping Initiative (OSSI), Monday, Sep. 13, 2010, at the Westfields Marriott Conference Center in Chantilly, VA. Administrator Bolden is joined on the panel from left to right by Leland Melvin, Education Design Team Co-Chair and NASA Astronaut; William Kelly, Manager, Public Affairs, American Society for Engineering Education; Michael Lach, Special Assistant for STEM Education, U.S. Department of Education; Cora Marrett, Acting Director, National Science Foundation; and James Stofan, NASA Acting Associate Administrator for Education. (Photo Credit: NASA/Carla Cioffi)

  1. NASA Education Stakeholder's Summit

    NASA Image and Video Library

    2010-09-12

    NASA Student Ambassadors and Facilitator are seen on a panel at the NASA Education Stakeholders’ Summit One Stop Shopping Initiative (OSSI), Monday, Sep. 13, 2010, at the Westfields Marriott Conference Center in Chantilly, VA. From left to right are: Quenton Bonds, University of South Florida; Geoffrey Wawrzyniak, Purdue University; Heriberto Reynoso, University of Texas at Brownsville; Marie Kingbird-Lowry, Leech Lake Tribal College; Kareen Borders, University of Washington; Katelyn Doran, University of North Carolina at Charlotte and Ashanti Johnson, PhD, Executive Director, Institute for Broadening Participation. (Photo Credit: NASA/Carla Cioffi)

  2. Pavonis Mons Summit Caldera

    NASA Technical Reports Server (NTRS)

    2002-01-01

    [figure removed for brevity, see original site]

    This image shows part of the summit caldera of Pavonis Mons. Pavonis the middle of three Tharsis volcanos that form a line southeast of Olympus Mons and northwest of Vallis Marineris. On Earth volcanic calderas usually form when a massive eruption has emptied out the magma chamber and the 'roof' of the chamber collapses into the resultant space. It is likely that summit calderas on Martian volcanoes form in a similar manner.

    Note: this THEMIS visual image has not been radiometrically nor geometrically calibrated for this preliminary release. An empirical correction has been performed to remove instrumental effects. A linear shift has been applied in the cross-track and down-track direction to approximate spacecraft and planetary motion. Fully calibrated and geometrically projected images will be released through the Planetary Data System in accordance with Project policies at a later time.

    NASA's Jet Propulsion Laboratory manages the 2001 Mars Odyssey mission for NASA's Office of Space Science, Washington, D.C. The Thermal Emission Imaging System (THEMIS) was developed by Arizona State University, Tempe, in collaboration with Raytheon Santa Barbara Remote Sensing. The THEMIS investigation is led by Dr. Philip Christensen at Arizona State University. Lockheed Martin Astronautics, Denver, is the prime contractor for the Odyssey project, and developed and built the orbiter. Mission operations are conducted jointly from Lockheed Martin and from JPL, a division of the California Institute of Technology in Pasadena.

  3. Ebook Summit: Our Ebook Challenge

    ERIC Educational Resources Information Center

    Library Journal, 2010

    2010-01-01

    Over 2000 participants made the daylong programming at the "Library Journal"/"School Library Journal" Virtual Ebook Summit, September 29, a robust conversation and not just within the summit interface but also in tweets with the #ebooksummit hashtag (and beyond) and in libraries across the country where participants logged in to take part. The…

  4. Ebook Summit: Our Ebook Challenge

    ERIC Educational Resources Information Center

    Library Journal, 2010

    2010-01-01

    Over 2000 participants made the daylong programming at the "Library Journal"/"School Library Journal" Virtual Ebook Summit, September 29, a robust conversation and not just within the summit interface but also in tweets with the #ebooksummit hashtag (and beyond) and in libraries across the country where participants logged in to take part. The…

  5. Port Stakeholder Summit - April 2014

    EPA Pesticide Factsheets

    EPA's National Port Stakeholders Summit, Advancing More Sustainable Ports, focused on actions to protect air quality while reducing climate risk and supporting economic growth, making ports more environmentally sustainable.

  6. IT Summit 2010 - Award Winners

    NASA Image and Video Library

    NASA CIO Linda Cureton announces this year’s IT Summit award winners. These awards recognize achievement in six key areas for contributions that have aided in NASA achieving mission goals and objec...

  7. IT Summit 2010 - Promo 2

    NASA Image and Video Library

    NASA CIO Linda Cureton offers a preview of the NASA IT Summit, which will feature IT experts from the public and private sectors speaking about IT collaboration, innovation, waves of the future, in...

  8. AGU hosts Leadership Summit on Climate Science Communication

    NASA Astrophysics Data System (ADS)

    Cairns, Ann

    2011-03-01

    Building on informal meetings among a small group of scientific societies and research institutions concerned with climate science, AGU hosted a Leadership Summit on Climate Science Communication, 7-8 March 2011, in Washington, D. C. Presidents, executive directors, and senior public policy staff from 17 science organizations engaged with experts in the social sciences regarding effective communication of climate science and with practitioners from agriculture, energy, and the military. The keynote speaker for the summit was Bob Inglis, former U.S. representative from South Carolina's 4th Congressional District.

  9. Drug repositioning summit: finding new routes to success.

    PubMed

    Campas, Clara

    2009-03-01

    The Third Annual Drug Repositioning Summit 2008 was held at the Hyatt Harborside Hotel in Boston, Massachusetts, October 6-7, and focused on new strategies for drug repositioning. The meeting, organized by The Cambridge Healthtech Institute, brought together a panel of speakers from the industry and the academia, who discussed and proposed new routes for success in drug repositioning based on their own experience in the field. This meeting report summarizes the most relevant presentations and issues discussed.

  10. Crisis at the summit.

    PubMed

    Parsons, George D; Pascale, Richard T

    2007-03-01

    An unrecognized affliction is striking certain gifted performers at the top of their game. Its cause, paradoxically, is success itself. These stars, who thrive on conquering new challenges, can lose their bearings and question their purpose once a job has been mastered. A vague dissatisfaction gives way to confusion and then to inner turmoil. Left unattended, this summit syndrome can derail promising careers. The syndrome has three phases. In the approach phase, when most of the challenges of a current job have been met, sufferers tend to push harder in a vain attempt to recapture the adrenaline rush of the climb. Then, in the plateauing phase, when virtually all the challenges have been conquered, these individuals, who are incapable of coasting, bear down to try to produce ever more stellar results, but to less effect and greater dissatisfaction. This leads to the terminal descending phase, when performance slips noticeably. As their superstar status fades, they jump ship, accept demotions, or take lateral transfers. It's a terrible waste, for if the syndrome is recognized, steps can be taken before performance slips to dispel the confusion and set the stage for productive growth to the next assignment. There are four parts to this process: First, understand your "winning formula"--the characteristic way you approach a situation--and the vital part it plays in feeling stale or losing your edge. Second, reconnect with your core purpose in life. Third, recast your current, or future, job to better align your inner aspirations with the external requirements of your work. And fourth, create a developmental path by honing a handful of core leadership competencies. None of this is easy, but for talented individuals--and the organizations that rely on them--the vaccine of preventive awareness is far better than gambling on an after-the-fact cure once the crisis is full-blown.

  11. Monitoring compliance with high-level commitments in health: the case of the CARICOM Summit on Chronic Non-Communicable Diseases.

    PubMed

    Samuels, T Alafia; Kirton, John; Guebert, Jenilee

    2014-04-01

    The CARICOM Summit on Chronic Non-Communicable Diseases - the first government summit ever devoted to noncommunicable diseases (NCDs) - was convened by the Caribbean Community (CARICOM) in Trinidad and Tobago in September 2007. Leaders in attendance issued the declaration of Port of Spain, a call for the prevention and control of four major NCDs and their risk factors. An accountability instrument for monitoring compliance with summit commitments was developed for CARICOM by the University of the West Indies in 2008 and revised in 2010. The instrument - a one-page colour-coded grid with 26 progress indicators - is updated annually by focal points in Caribbean health ministries, verified by each country's chief medical officer and presented to the annual Caucus of Caribbean Community Ministers of Health. In this study, the G8 Research Group's methods for assessing compliance were applied to the 2009 reporting grid to assess each country's performance. Given the success of the CARICOM Summit, a United Nations high-level meeting of the General Assembly on the prevention and control of NCDs was held in September 2011. In May 2013 the World Health Assembly adopted nine global targets and 25 indicators to measure progress in NCD control. This study shows that the CARICOM monitoring grid can be used to document progress on such indicators quickly and comprehensibly. An annual reporting mechanism is essential to encourage steady progress and highlight areas needing correction. This paper underscores the importance of accountability mechanisms for encouraging and monitoring compliance with the collective political commitments acquired at the highest level.

  12. Monitoring compliance with high-level commitments in health: the case of the CARICOM Summit on Chronic Non-Communicable Diseases

    PubMed Central

    Kirton, John; Guebert, Jenilee

    2014-01-01

    Abstract The CARICOM Summit on Chronic Non-Communicable Diseases – the first government summit ever devoted to noncommunicable diseases (NCDs) – was convened by the Caribbean Community (CARICOM) in Trinidad and Tobago in September 2007. Leaders in attendance issued the declaration of Port of Spain, a call for the prevention and control of four major NCDs and their risk factors. An accountability instrument for monitoring compliance with summit commitments was developed for CARICOM by the University of the West Indies in 2008 and revised in 2010. The instrument – a one-page colour-coded grid with 26 progress indicators – is updated annually by focal points in Caribbean health ministries, verified by each country’s chief medical officer and presented to the annual Caucus of Caribbean Community Ministers of Health. In this study, the G8 Research Group’s methods for assessing compliance were applied to the 2009 reporting grid to assess each country’s performance. Given the success of the CARICOM Summit, a United Nations high-level meeting of the General Assembly on the prevention and control of NCDs was held in September 2011. In May 2013 the World Health Assembly adopted nine global targets and 25 indicators to measure progress in NCD control. This study shows that the CARICOM monitoring grid can be used to document progress on such indicators quickly and comprehensibly. An annual reporting mechanism is essential to encourage steady progress and highlight areas needing correction. This paper underscores the importance of accountability mechanisms for encouraging and monitoring compliance with the collective political commitments acquired at the highest level. PMID:24700994

  13. Summit Crater of Mauna Loa

    NASA Technical Reports Server (NTRS)

    2002-01-01

    Astronauts obtained this detailed image of the summit caldera of Mauna Loa volcano, called Mokuaweoweo Caldera. Mauna Loa is the largest volcano on our planet-the summit elevation is 4,170 m (over 13,600 ft), but the volcano's summit rises 9 km above the sea floor. The sharp features of the summit caldera and lava flows that drain outward from the summit are tribute to the fact that Mauna Loa is one of the Earth's most active volcanoes. The most recent eruption was in 1984. The straight line the cuts through the center of the crater from top to bottom is a rift zone-an area that pulls apart as magma reaches the surface. A weather observatory run by NOAA's Climate Monitoring and Diagnostics Lab is on the volcano's north slope at 11,000 ft (3397 m). This facility, known as the Mauna Loa Observatory, is the site where scientists have documented the constantly increasing concentrations of global atmospheric carbon dioxide. Other resources about Mauna Loa: http://wwwhvo.wr.usgs.gov/maunaloa/ http://www.cmdl.noaa.gov/obop/mlo/ http://www.volcano.si.edu/gvp/usgs/vol_archive/maunaloa.htm Astronaut photograph ISS005-E-7002 was provided by the Earth Sciences and Image Analysis Laboratory at Johnson Space Center. Additional images taken by astronauts and cosmonauts can be viewed at the NASA-JSC Gateway to Astronaut Photography of Earth.

  14. Beyond the World Food Summit.

    PubMed

    Mulvany, P

    1997-08-01

    While most speakers at the 1996 World Food Summit expressed concern about the injustice that forces more than 800 million people worldwide to live with hunger, some sought solutions through economic and social development while others called for a more liberal marketplace. Among world leaders, only Fidel Castro raised issues and challenges that addressed some of the underlying causes of malnutrition. The Plan of Action that grew out of the Summit has only one measurable commitment, which is to halve the number of undernourished people by 2015. The other six commitments, while diluted, contain important objectives even though they give little emphasis to the underlying causes of poverty or hunger. The Summit process, however, did contribute to the fact that food-related issues are now placed higher on the world agenda because many of these issue were raised by civil service organizations (CSOs) at the Summit's parallel NGO (nongovernmental organization) forum. In fact, one of the most positive outcomes of the Summit may prove to be the increased effectiveness of the CSOs as a result of the creation of improved networks in preparation for the Summit. The CSOs contributed examples of how food security could be improved, published an active site on the World Wide Web, and challenged the statements of governments. In addition to raising trade issues, CSOs also lobbied for sustainable agriculture and agricultural biodiversity. In fact, CSOs may have to set a new action agenda for the formal sector to encourage development of new institutions and new global forums that give NGOs a place at the table.

  15. Atrial Arrhythmias in Astronauts - Summary of a NASA Summit

    NASA Technical Reports Server (NTRS)

    Barr, Yael R.; Watkins, Sharmila D.; Polk, J. D.

    2010-01-01

    Background and Problem Definition: To evaluate NASA s current standards and practices related to atrial arrhythmias in astronauts, Space Medicine s Advanced Projects Section at the Johnson Space Center was tasked with organizing a summit to discuss the approach to atrial arrhythmias in the astronaut cohort. Since 1959, 11 cases of atrial fibrillation, atrial flutter, or supraventricular tachycardia have been recorded among active corps crewmembers. Most of the cases were paroxysmal, although a few were sustained. While most of the affected crewmembers were asymptomatic, those slated for long-duration space flight underwent radiofrequency ablation treatment to prevent further episodes of the arrhythmia. The summit was convened to solicit expert opinion on screening, diagnosis, and treatment options, to identify gaps in knowledge, and to propose relevant research initiatives. Summit Meeting Objectives: The Atrial Arrhythmia Summit brought together a panel of six cardiologists, including nationally and internationally renowned leaders in cardiac electrophysiology, exercise physiology, and space flight cardiovascular physiology. The primary objectives of the summit discussions were to evaluate cases of atrial arrhythmia in the astronaut population, to understand the factors that may predispose an individual to this condition, to understand NASA s current capabilities for screening, diagnosis, and treatment, to discuss the risks associated with treatment of crewmembers assigned to long-duration missions or extravehicular activities, and to discuss recommendations for prevention or management of future cases. Summary of Recommendations: The summit panel s recommendations were grouped into seven categories: Epidemiology, Screening, Standards and Selection, Treatment of Atrial Fibrillation Manifesting Preflight, Atrial Fibrillation during Flight, Prevention of Atrial Fibrillation, and Future Research

  16. ATP-binding cassette G5/G8 deficiency causes hypertriglyceridemia by affecting multiple metabolic pathways.

    PubMed

    Méndez-González, Jesús; Julve, Josep; Rotllan, Noemí; Llaverias, Gemma; Blanco-Vaca, Francisco; Escolà-Gil, Joan Carles

    2011-12-01

    Mutations in ABCG5 or ABCG8 transporters are responsible for sitosterolemia, an autosomal recessive disease characterized by the accumulation of plant sterols. The aim of this study was to investigate the effects of ABCG5 and ABCG8 deficiency on TG metabolism in mice. Experiments were carried out in wild-type (G5/G8+/+) mice, mice heterozygous for ABCG5 and ABCG8 deficiency (G5/G8+/-) and ABCG5/G8-deficient (G5/G8-/-) mice fed a chow diet. Plasma TG were 2.6 and 4.3-fold higher in fasted G5/G8+/- and G5/G8-/- mice, respectively, than in G5/G8+/+ mice. Postprandial TG were 5-fold higher in G5/G8-/- mice. TG metabolism studies indicate that: first, the fractional catabolic rate was significantly lower in G5/G8+/- (1.3-fold) and G5/G8-/- mice (1.5-fold) compared to G5/G8+/+ and postheparin plasma lipoprotein lipase activities were significantly lower in G5/G8+/- (1.8-fold) and G5/G8-/- mice (5.4-fold) than in G5/G8+/+. Second, liver TG secretion was 1.3-fold higher in G5/G8+/- and G5/G8-/- than in G5/G8+/+ mice and this was associated with an increase in liver LXR, FAS, ACAC and CD36 gene expression. Third, TG intestinal secretion, determined after an oral fat gavage of glycerol tri[9,10(n)-(3)H] oleate, was 5.8-fold higher in G5/G8-/- than in G5/G8+/+ mice. Also, the HOMA index was 2.6-fold higher in G5/G8-/- than in G5/G8+/+ mice, reflecting a degree of insulin resistance. In conclusion, ABCG5/G8 deficiency in mice fed a chow diet markedly raises TG levels by impairing TG catabolism and by increasing liver and intestinal TG secretion.

  17. Humans to Mars Summit 2014

    NASA Image and Video Library

    2014-04-22

    NASA Administrator Charles Bolden delivers the opening keynote address at the Humans to Mars Summit on April 22, 2014 at George Washington University in Washington, DC. Administrator Bolden spoke of NASA's path to the human exploration of Mars during his remarks. Photo Credit: (NASA/Joel Kowsky)

  18. Humans to Mars Summit 2014

    NASA Image and Video Library

    2014-04-22

    NASA Administrator Charles Bolden answers questions from the audience after giving the opening keynote address at the Humans to Mars Summit on April 22, 2014 at George Washington University in Washington, DC. Administrator Bolden spoke of NASA's path to the human exploration of Mars during his remarks. Photo Credit: (NASA/Joel Kowsky)

  19. Humans to Mars Summit 2014

    NASA Image and Video Library

    2014-04-22

    Michael Gazarik, NASA Associate Administrator for Space Technology gives a short presentation on NASA's human exploration path to Mars during a panel discussion moderated by PBS NewsHour's Miles O'Brien at the Humans to Mars Summit on April 22, 2014 at George Washington University in Washington, DC. Photo Credit: (NASA/Joel Kowsky)

  20. Humans to Mars Summit 2014

    NASA Image and Video Library

    2014-04-22

    Miles O'Brien, science correspondant for PBS NewsHour, left, leads a panel discussion on Mars exploration with William Gerstenmaier, NASA Associatate Administrator for Human Explorations and Operations, center, and Michael Gazarik, NASA Associate Administrator for Space Technology, left, at the Humans to Mars Summit on April 22, 2014 at George Washington University in Washington, DC. Photo Credit: (NASA/Joel Kowsky)

  1. Humans to Mars Summit 2014

    NASA Image and Video Library

    2014-04-22

    William Gerstenmaier, NASA Associatate Administrator for Human Exploration and Operations, right, answers a question during a panel discussion moderated by PBS NewsHour's Miles O'Brien at the Humans to Mars Summit on April 22, 2014 at George Washington University in Washington, DC. Photo Credit: (NASA/Joel Kowsky)

  2. Higher Ambitions Summit. Rapporteur Report

    ERIC Educational Resources Information Center

    Nash, Ian

    2014-01-01

    The Sutton Trust and Pearson two-day summit on higher ambitions in apprenticeships and vocational education drew more than 120 leaders in education, training and employment, policy makers, academics, and researchers to London. Delegates heard from political leaders stressing the importance they attach to high-quality apprenticeships. Presentations…

  3. Higher Ambitions Summit. Rapporteur Report

    ERIC Educational Resources Information Center

    Nash, Ian

    2014-01-01

    The Sutton Trust and Pearson two-day summit on higher ambitions in apprenticeships and vocational education drew more than 120 leaders in education, training and employment, policy makers, academics, and researchers to London. Delegates heard from political leaders stressing the importance they attach to high-quality apprenticeships. Presentations…

  4. Summit Panorama with Rover Deck

    NASA Technical Reports Server (NTRS)

    2005-01-01

    [figure removed for brevity, see original site] Click on the image for Summit Panorama with Rover (QTVR)

    The panoramic camera on NASA's Mars Exploration Rover Spirit took the hundreds of images combined into this 360-degree view, the 'Husband Hill Summit' panorama. The images were acquired on Spirit's sols 583 to 586 (Aug. 24 to 27, 2005), shortly after the rover reached the crest of 'Husband Hill' inside Mars' Gusev Crater. This is the largest panorama yet acquired from either Spirit or Opportunity. The panoramic camera shot 653 separate images in 6 different filters, encompassing the rover's deck and the full 360 degrees of surface rocks and soils visible to the camera from this position. This is the first time the camera has been used to image the entire rover deck and visible surface from the same position. Stitching together of all the images took significant effort because of the large changes in resolution and parallax across the scene.

    The image is an approximately true-color rendering using the 750-nanometer, 530-nanometer and 480-nanometer filters for the surface, and the 600-nanometer and 480-nanometer filters for the rover deck. Image-to-image seams have been eliminated from the sky portion of the mosaic to better simulate the vista a person standing on Mars would see.

    This panorama provided the team's first view of the 'Inner Basin' region (center of the image), including the enigmatic 'Home Plate' feature seen from orbital data. After investigating the summit area, Spirit drove downhill to get to the Inner Basin region. Spirit arrived at the summit from the west, along the direction of the rover tracks seen in the middle right of the panorama. The peaks of 'McCool Hill' and 'Ramon Hill' can be seen on the horizon near the center of the panorama. The summit region itself is a broad, windswept plateau. Spirit spent more than a month exploring the summit region, measuring the chemistry and mineralogy of soils and rocky outcrops at the peak

  5. Molecular characterization of human G8P[4] rotavirus strains in Italy: proposal of a more complete subclassification of the G8 genotype in three major lineages.

    PubMed

    Ianiro, G; Delogu, R; Bonomo, P; Castiglia, P; Ruggeri, F M; Fiore, L

    2014-01-01

    In 2011, two children with acute rotavirus gastroenteritis were hospitalized in Sardinia, Italy. Two RVA strains with G8P[4] genotype were detected in their stools, and were named SS56/2011 and SS65/2011. The aim of the study was to characterize these two rare strains, collected within a national RVA gastroenteritis surveillance program. Eight of the 11 RVA genes were sequenced and phylogenetic analysis performed. VP7 amino acid sequence was also analyzed. Sequencing of genes encoding the VP4, VP6, VP7, and NSP1-5 proteins classified both strains as G8-P[4]-I2-A2-N2-T2-E2-H2, not detected previously in Italy. Phylogenetic analysis revealed that most genes of Italian RVA strains were closely similar to typical DS-1 like strains circulating worldwide, whereas the VP7 gene was strictly related to G8 strains firstly reported in Africa. This finding of G8P[4] RVA strains with a DS-1 like genomic constellation also in a southern European country further confirms the wide circulation of this uncommon genotype in the world. Comparison of the deduced amino acid sequence of the VP7 capsid protein of the Italian G8P[4] RVA strains with sequences reported previously suggests that the G8 genotype should be divided into three major lineages.

  6. Garan at Women's Cancer Summit

    NASA Image and Video Library

    2013-02-04

    NASA astronaut Ron Garan gives a keynote address at the Susan G. Komen International Global Women's Cancer Summit, held on World Cancer Day, Monday, February 4, 2013 in Washington, D.C. Attendees include world leaders in health and women’s cancers, experts in technology and innovation; government leaders, private sector and industry leaders, members of the global health community, media and representatives from community-level organizations. Photo Credit: (NASA/Carla Cioffi)

  7. Women's human rights at the World Summit for Social Development.

    PubMed

    Fried, S

    1995-01-01

    The Copenhagen Hearing on Economic Justice and Women's Human Rights was held on March 7, 1995 in conjunction with the NGO (nongovernmental organization) Forum during the UN World Summit on Social Development (the Social Summit). During the Copenhagen Hearing, 10 women from around the world testified on a wide range of topics connected with the issue of providing tangible meaning to the indivisibility of women's human rights. Also emphasized was the complexity of the US government in perpetrating abuses against women's human rights, either directly or indirectly. The NGO Forum resulted in several hundred NGOs signing The Quality Benchmark for the Social Summit and The Copenhagen Alternative Declaration, which pointed out the need to critique conventional economic and social policies. While many of the concerns raised at the NGO Forum were not reflected in the Summit's Programme of Action, one of the Programme's 10 commitments called for the promotion of gender equality and improvement in the status of women. The Programme also recognized the burden placed on women by poverty and social disintegration; accepted a broad definition of "family"; called for a quantitative consideration of the value of unremunerated work; and advanced the rights of workers in general, migrant workers, and indigenous people. The capacity of NGOs and other grassroots groups to demand implementation of international agreements and adherence to international human rights standards was also strengthened. Specifically, such groups may urge governments to 1) meet with women's NGOs to discuss implementation of the Social Summit Declaration and Programme of Action; 2) make a national commitment to implement the Platform of Action of the Fourth World Conference on Women; and 3) commit to the Pledge to Gender Justice, particularly to the implementation of international agreements in local and national laws and policies.

  8. Making G8 leaders deliver: an analysis of compliance and health commitments, 1996-2006.

    PubMed

    Kirton, John J; Roudev, Nikolai; Sunderland, Laura

    2007-03-01

    International health policy-makers now have a variety of institutional instruments with which to pursue their global and national health goals. These instruments range from the established formal multilateral organizations of the United Nations to the newer restricted-membership institutions of the Group of Eight (G8). To decide where best to deploy scarce resources, we must systematically examine the G8's contributions to global health governance. This assessment explores the contributions made by multilateral institutions such as the World Health Organization, and whether Member States comply with their commitments. We assessed whether G8 health governance assists its member governments in managing domestic politics and policy, in defining dominant normative directions, in developing and complying with collective commitments and in developing new G8-centred institutions. We found that the G8's performance improved substantially during the past decade. The G8 Member States function equally well, and each is able to combat diseases. Compliance varied among G8 Member States with respect to their health commitments, and there is scope for improvement. G8 leaders should better define their health commitments and set a one-year deadline for their delivery. In addition, Member States must seek WHO's support and set up an institution for G8 health ministers.

  9. Proceedings of the 2013 CINP summit: innovative partnerships to accelerate CNS drug discovery for improved patient care.

    PubMed

    Phillips, Anthony George; Hongaard-Andersen, Peter; Moscicki, Richard A; Sahakian, Barbara; Quirion, Rémi; Krishnan, K Ranga Rama; Race, Tim

    2014-12-25

    Central nervous system (CNS) diseases and, in particular, mental health disorders, are becoming recognized as the health challenge of the 21(st) century. Currently, at least 10% of the global population is affected by a mental health disorder, a figure that is set to increase year on year. Meanwhile, the rate of development of new CNS drugs has not increased for many years, despite unprecedented levels of investment. In response to this state of affairs, the Collegium Internationale Neuro-Psychopharmacologicum (CINP) convened a summit to discuss ways to reverse this disturbing trend through new partnerships to accelerate CNS drug discovery. The objectives of the Summit were to explore the issues affecting the value chain (i.e. the chain of activities or stakeholders that a company engages in/with to deliver a product to market) in brain research, thereby gaining insights from key stakeholders and developing actions to address unmet needs; to identify achievable objectives to address the issues; to develop action plans to bring about measurable improvements across the value chain and accelerate CNS drug discovery; and finally, to communicate recommendations to governments, the research and development community, and other relevant stakeholders. Summit outputs include the following action plans, aligned to the pressure points within the brain research-drug development value chain: Code of conduct dealing with conflict of interest issues, Prevention, early diagnosis, and treatment, Linking science and regulation, Patient involvement in trial design, definition of endpoints, etc., Novel trial design, Reproduction and confirmation of data, Update of intellectual property (IP) laws to facilitate repurposing and combination therapy (low priority), Large-scale, global patient registries, Editorials on nomenclature, biomarkers, and diagnostic tools, and Public awareness, with brain disease advocates to attend G8 meetings and World Economic Forum (WEF) Annual meetings in

  10. Proceedings of the 2013 CINP Summit: Innovative Partnerships to Accelerate CNS Drug Discovery for Improved Patient Care

    PubMed Central

    Hongaard-Andersen, Peter; Moscicki, Richard A.; Sahakian, Barbara; Quirion, Rémi; Krishnan, K. Ranga Rama; Race, Tim

    2015-01-01

    Central nervous system (CNS) diseases and, in particular, mental health disorders, are becoming recognized as the health challenge of the 21st century. Currently, at least 10% of the global population is affected by a mental health disorder, a figure that is set to increase year on year. Meanwhile, the rate of development of new CNS drugs has not increased for many years, despite unprecedented levels of investment. In response to this state of affairs, the Collegium Internationale Neuro-Psychopharmacologicum (CINP) convened a summit to discuss ways to reverse this disturbing trend through new partnerships to accelerate CNS drug discovery. The objectives of the Summit were to explore the issues affecting the value chain (i.e. the chain of activities or stakeholders that a company engages in/with to deliver a product to market) in brain research, thereby gaining insights from key stakeholders and developing actions to address unmet needs; to identify achievable objectives to address the issues; to develop action plans to bring about measurable improvements across the value chain and accelerate CNS drug discovery; and finally, to communicate recommendations to governments, the research and development community, and other relevant stakeholders. Summit outputs include the following action plans, aligned to the pressure points within the brain research-drug development value chain: Code of conduct dealing with conflict of interest issues,Prevention, early diagnosis, and treatment,Linking science and regulation,Patient involvement in trial design, definition of endpoints, etc.,Novel trial design,Reproduction and confirmation of data,Update of intellectual property (IP) laws to facilitate repurposing and combination therapy (low priority),Large-scale, global patient registries,Editorials on nomenclature, biomarkers, and diagnostic tools, andPublic awareness, with brain disease advocates to attend G8 meetings and World Economic Forum (WEF) Annual meetings in Davos

  11. Annual report of the Summit Members' Working Group on Controlled Thermonuclear Fusion (Fusin Working Group (FWG))

    SciTech Connect

    none,

    1987-04-01

    The Summit Members' Working Group on Controlled Thermonuclear Fusion (Fusion Working Group (FWG)) was established in 1983 in response to the Declaration of the Heads of State and Government at the Versailles Economic Summit meeting of 1982, and in response to the subsequent report of the Working Group in Technology, Growth and Employment (TGE) as endorsed at the Williamsburg Summit meeting, 1983. This document contains the complete written record of each of the three FWG meetings which include the minutes, lists of attendees, agendas, statements, and summary conclusions as well as the full reports of the Technical Working Party. In addition, there is a pertinent exchange of correspondence between FWG members on the role of the Technical Working Party and a requested background paper on the modalities associated with a possible future ETR project.

  12. World Summit for Social Development: year-end update.

    PubMed

    Chasek, P; Schmidt, C; Jordan, R

    1995-12-18

    This report is devoted to the follow-up activities of the 50th UN General Assembly pertaining to Copenhagen's World Summit for Social Development's Program of Action, which was adopted by the Conference on March 12, 1995. Summaries are provided of the background history to the Summit, the activities of the UN Commission for Social Development, the Economic and Social Council meetings, and General Assembly delegate discussion. The draft resolution on the implementation of the World Summit on Social Development generated lengthy discussions and was expected to be adopted by the General Assembly Plenary before adjournment in December 22, 1995. Follow-up under the draft resolution is expected to include the joint actions within the UN system of the General Assembly, the ECOSOC, and the Commission for Social Development. The resolution includes an overall review and appraisal of UN progress in implementing Copenhagen's Declaration and Program of Action, which will occur in the year 2000. The draft resolution urges the Secretary-General, the World Bank, and the International Monetary Fund to study the impact of structural adjustment programs on economic and social development. Nine other specific directives are listed in the draft resolution. Related activities for 1996 are identified as a special meeting of the Commission on Social Development, which is scheduled for May 21-30, 1996, in New York. The meeting will discuss the strategies for poverty alleviation, meeting human needs, and promotion of self-reliance and community-based initiatives. Norway has initiated a planning meeting of three developed and three developing country representatives on a future conference. The conference would work towards a common definition of basic social programs, the implementation of the 20:20 concept, and ways to monitor implementation. Denmark is planning international seminars on social development issues.

  13. Coordination and Convening of the 2016 Arctic Science Summit Week

    SciTech Connect

    Hinzman, Larry D.

    2016-11-13

    The Arctic Science Summit Week, Arctic Observing Summit, Arctic Council Senior Arctic Officials, Model Arctic Council, and International Arctic Assembly were convened on the campus of the University of Alaska Fairbanks with great productivity and satisfaction of the participants. We were pleased to welcome over 1000 participants from 30 different nations and over 130 different institutions. The organization and execution of these meetings was extensive and complex involving more than 250 coordinators, volunteers and contributors from across Alaska. The participants were enthusiastic in their praise of the content and accomplishments of the meeting, but they were equally happy about the genuine welcome offered to our guests by the people of Alaska. Hosting a complex event such as this summit required an army of supporting services and we were blessed to have volunteers from Fairbanks, North Pole, Anchorage and other communities throughout Alaska helping us meet these needs. This truly was an event hosted by the people of Alaska. The significance of these events cannot be overstated. The US and global communities are finally coming to the realization of the important role that the Arctic plays in international politics, economics, and science. The Arctic has experienced tremendous changes in recent years, offering new opportunities that may be addressed through international collaborations, and serious challenges that must be addressed through active investment, adaptation and national and international coordination. Over 10% of the meeting participants were indigenous peoples, from indigenous organizations or hailed from small remote communities. This is still lower than we had hoped, but it is greater participation than similar meetings have experienced in the past. It is through such engagement that we can attack problems related to the changing environment, stagnant economies, and social ills.

  14. 16 CFR Appendix G8 to Part 305 - Boilers-Electric

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 16 Commercial Practices 1 2010-01-01 2010-01-01 false Boilers-Electric G8 Appendix G8 to Part 305 Commercial Practices FEDERAL TRADE COMMISSION REGULATIONS UNDER SPECIFIC ACTS OF CONGRESS RULE CONCERNING... Part 305—Boilers—Electric Manufacturer's rated heating capacities (Btu's/hr.) Range of annual fuel...

  15. 16 CFR Appendix G8 to Part 305 - Boilers-Electric

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 16 Commercial Practices 1 2011-01-01 2011-01-01 false Boilers-Electric G8 Appendix G8 to Part 305 Commercial Practices FEDERAL TRADE COMMISSION REGULATIONS UNDER SPECIFIC ACTS OF CONGRESS RULE CONCERNING... Part 305—Boilers—Electric Manufacturer's rated heating capacities (Btu's/hr.) Range of annual fuel...

  16. 16 CFR Appendix G8 to Part 305 - Boilers-Electric

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 16 Commercial Practices 1 2013-01-01 2013-01-01 false Boilers-Electric G8 Appendix G8 to Part 305 Commercial Practices FEDERAL TRADE COMMISSION REGULATIONS UNDER SPECIFIC ACTS OF CONGRESS RULE CONCERNING... Part 305—Boilers—Electric Manufacturer's rated heating capacities (Btu's/hr.) Range of annual...

  17. 16 CFR Appendix G8 to Part 305 - Boilers-Electric

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 16 Commercial Practices 1 2012-01-01 2012-01-01 false Boilers-Electric G8 Appendix G8 to Part 305 Commercial Practices FEDERAL TRADE COMMISSION REGULATIONS UNDER SPECIFIC ACTS OF CONGRESS RULE CONCERNING... Part 305—Boilers—Electric Manufacturer's rated heating capacities (Btu's/hr.) Range of annual...

  18. Fifth Annual Stem Cell Summit.

    PubMed

    Knowlton, Daniel

    2010-04-01

    The Fifth Annual Stem Cell Summit, held in New York, included topics covering new commercial developments in the research field of stem cell-based therapies. This conference report highlights selected presentations on embryonic and adult stem cells, stem cell-based therapies for the treatment of orthopedic and cardiovascular indications and inflammatory diseases, as well as technologies for processing and storing stem cells. Investigational therapies discussed include placental expanded (PLX) cells (Pluristem Therapeutics Inc), StemEx (Gamida-Teva Joint Venture/Teva Pharmaceutical Industries Ltd) and remestemcel-L (Osiris Therapeutics Inc/Genzyme Corp/JCR Pharmaceuticals Co Ltd/ Mochida Pharmaceutical Co Ltd).

  19. The Controlling Cancer Summit, 17-19 May 2016, London, UK.

    PubMed

    Babina, Irina S

    2016-10-01

    The Controlling Cancer Summit, London, UK, 17-19 May 2016 The Controlling Cancer Summit is an intimate informal meeting that annually gathers international academic and clinical researchers to network and debate the current advancements and challenges of oncology research. This year, it focused not only on diagnostic/prognostic biomarkers and genetic influences in cancer but also novel and sometimes unconventional therapeutic interventions. This report will summarize the meeting highlights that contribute to our comprehension of cancer biology and new innovative ways to target this disease.

  20. 47. Spring 1935 Harold J. Cook, photographer "Summit Road construction. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    47. Spring 1935 Harold J. Cook, photographer "Summit Road construction. Early stage of road tunnel construction, while tunnel was being driven on Summit Road, Scotts Bluff National Monument." - Scotts Bluff Summit Road, Gering, Scotts Bluff County, NE

  1. Major Events Coordinated Security Solutions Technical Report Closeout (MECSS): The Application of Science and Technology to Reduce Risk for V2010 and G8/G20 Summits

    DTIC Science & Technology

    2010-12-01

    Équipe intégrée de sécurité publique de la C.-B., Force opérationnelle interarmées des Forces canadiennes pour les Jeux olympiques et Santé publique...weapons) entering V2010 venues. However, given the Winter Olympic and Paralympic Games’ posture as a sporting event rather than a traditional

  2. 11th Annual Legislative Summit, 2008

    ERIC Educational Resources Information Center

    National Indian Education Association, 2008

    2008-01-01

    Several papers were presented during the 11th Annual National Indian Education Association (NIEA) Legislative Summit. This volume contains the following briefing papers presented during the summit: (1) Reauthorization of No Child Left Behind Strengthen Native American Education; (2) The Johnson O'Malley Program; (3) Legislation to Address…

  3. Summit on Improving the Economics of America's Nuclear Power Plants

    SciTech Connect

    Collins, John; Mason, Charles

    2016-09-01

    The Summit on Improving the Economics of America’s Nuclear Power Plants was convened May 19, 2016, by Secretary of Energy Ernest Moniz and co-sponsored by Idaho Senator Mike Crapo to stress the importance of existing nuclear reactors in meeting our nation’s energy goals. The summit was also designed to identify and discuss policy options that can be pursued at federal and state levels to address economic challenges, as well as technical options that utilities can use to improve the economic competitiveness of operating nuclear power plants (NPPs) and avoid early plant retirements that are driven by temporary market conditions. The owners of NPPs face difficult economic decisions and are working to improve the performance of existing NPPs. However, it soon became clear that some of the actions taken by states and regional markets have had an impact on the economic viability of existing power plants, including carbon free NPPs. Summit speakers identified concepts and actions that could be taken at state and federal levels to improve the economics of the existing fleet within these regulated and restructured electricity markets. This report summarizes the speeches, concepts, and actions taken.

  4. European Heart Rhythm Association Summit report 2014.

    PubMed

    Sutton, Richard; Leclercq, Christophe; Kuck, Karl-Heinz

    2016-05-01

    Across Europe, the role of the welfare state is constantly being questioned and even eroded. At the same time, funding sources for post-graduate medical education and training are under attack as regulators review the working relationships between physicians and industry. Both of these issues have profound consequences for cardiologists and their patients, and were, therefore, chosen as the themes of the European Heart Rhythm Association (EHRA) 2014 Spring Summit held at Heart House, Sophia Antipolis, 25-26 March 2014. The meeting noted that some of the changes are already affecting patient care standards and that this is exacerbated by a reduction in research and education programmes. The principle conclusion was that EHRA must find better means of engagement with the authorities across Europe to ensure that its views are considered and that ethical patient care is preserved. Participants were particularly alarmed by the example from Sweden in which future healthcare planning appears to exclude the views of physicians, although this is not yet the case in other countries. The demand for greater transparency in relationships between physicians and industry was also discussed. Although intended to eliminate corruption, concern was expressed that such moves would cause long-term damage to education and research, threatening the future of congresses, whose role in these areas appears underestimated by the authorities. Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2015. For permissions please email: journals.permissions@oup.com.

  5. In Brief: Climate Adaptation Summit report released

    NASA Astrophysics Data System (ADS)

    Showstack, Randy

    2010-10-01

    “We understand from the science that we have no choice between mitigation and adaptation. We have to do both,” John Holdren, President Barack Obama's science and technology advisor, said at a 29 September meeting where he was presented with a new report about national and regional preparations for adapting to changing climate. The report is based on the National Climate Adaptation Summit, which was convened by the University Corporation for Atmospheric Research in May 2010. Stating that the United States must adapt to a changing climate now and prepare for increasing impacts on urban infrastructure, food, water, human health, and ecosystems in the coming decades, the report identifies a set of priorities for near-term action. Among the priorities are developing an overarching national strategy, with research, planning, and management components to guide federal climate change adaptation programs. Other priorities include improving coordination of federal plans and programs and creating a federal climate information portal and a clearinghouse of best practices and tool kits for adaptation. The report also identifies other priorities, including the need for support for assessments in the U.S. Global Change Research Program agency budgets, for increasing funding for research on vulnerability and impacts, and for initiating a regional series of ongoing climate adaptation forums. For more information, see http://www.joss.ucar.edu/events/2010/ncas/index.html.

  6. The Summit of Olympus Mons

    NASA Technical Reports Server (NTRS)

    2003-01-01

    [figure removed for brevity, see original site]

    Released 9 October 2003

    Bold scarps and extensional features (grabens) record multiple stages of caldera collapse at the summit of Olympus Mons. The wrinkle ridges are contractional features, and probably formed during the cooling of an ancient lava lake, prior to the collapse events. Olympus Mons is the largest volcano in our solar system, reaching heights of over 40 km tall from base to summit, with the base covering an area as large as the state of Arizona.

    Image information: VIS instrument. Latitude 18.5, Longitude 226.6 East (133.4 West). 19 meter/pixel resolution.

    Note: this THEMIS visual image has not been radiometrically nor geometrically calibrated for this preliminary release. An empirical correction has been performed to remove instrumental effects. A linear shift has been applied in the cross-track and down-track direction to approximate spacecraft and planetary motion. Fully calibrated and geometrically projected images will be released through the Planetary Data System in accordance with Project policies at a later time.

    NASA's Jet Propulsion Laboratory manages the 2001 Mars Odyssey mission for NASA's Office of Space Science, Washington, D.C. The Thermal Emission Imaging System (THEMIS) was developed by Arizona State University, Tempe, in collaboration with Raytheon Santa Barbara Remote Sensing. The THEMIS investigation is led by Dr. Philip Christensen at Arizona State University. Lockheed Martin Astronautics, Denver, is the prime contractor for the Odyssey project, and developed and built the orbiter. Mission operations are conducted jointly from Lockheed Martin and from JPL, a division of the California Institute of Technology in Pasadena.

  7. EASL HCC summit: liver cancer management.

    PubMed

    Sacco, Rodolfo; Gadaleta-Caldarola, Gennaro; Galati, Giovanni; Lombardi, Giuseppe; Mazza, GianCarlo; Cabibbo, Giuseppe

    2014-05-01

    EASL HCC Summit, Geneva, Switzerland, 13-16 February 2014. The European Association for the Study of the Liver (EASL) organized the 2014 EASL HCC Summit in Geneva, Switzerland. We discuss here the most interesting and provocative contents from the clinical program of the summit. The objective of this segment was to provide an in-depth review on the different management issues related to early detection, diagnosis and treatment of hepatocellular carcinoma, and, in addition, to highlight the ways of dealing with such an important and rapidly involving field.

  8. Finding Common Ground: Days of Dialogue Teaching Materials. Teaching for the Summit and Beyond.

    ERIC Educational Resources Information Center

    Alexander, Susan, Ed.

    Designed for elementary, secondary, and post-secondary classrooms and community use during the week of November 11-15, 1985--the week before the Reagan-Gorbachev Summit meetings in Geneva, Switzerland--these lesson plans and units accomplish two goals: (1) to inform young people and adults and raise the level of understanding around specific…

  9. Summit Fuels Push to Improve High Schools: Money, Initiatives Pledged during Two-Day Event

    ERIC Educational Resources Information Center

    Olson, Lynn

    2005-01-01

    The nation's governors adjourned their two-day summit on high schools armed with an expanded arsenal of political and financial commitments to prepare all students for success in college and the workplace. But despite the enthusiastic launch of two major initiatives at the February 26-27, 2005 meeting here, observers cautioned that improving…

  10. The aspen mortality summit; December 18 and 19, 2006; Salt Lake City, UT

    Treesearch

    Dale L. Bartos; Wayne D. Shepperd

    2010-01-01

    The USDA Forest Service Rocky Mountain Research Station sponsored an aspen summit meeting in Salt Lake City, Utah, on December 18 and19, 2006, to discuss the rapidly increasing mortality of aspen (Populus tremuloides) throughout the western United States. Selected scientists, university faculty, and managers from Federal, State, and non-profit agencies with experience...

  11. 77 FR 51731 - All-Terrain Vehicle Safety Summit

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-27

    ... COMMISSION 16 CFR Chapter II All-Terrain Vehicle Safety Summit AGENCY: Consumer Product Safety Commission... announcing its intent to hold a Summit on all-terrain vehicle (ATV) safety. The Summit will be held at the... information at the Summit should register by September 14, 2012; all other individuals who wish to attend the...

  12. Approach to Cape Tribulation Summit Stereo

    NASA Image and Video Library

    2015-01-08

    NASA Mars Exploration Rover Opportunity recorded this view of the summit of Cape Tribulation, on the western rim of Endeavour Crater on the day before the rover drove to the top. You need 3D glasses to view this image.

  13. Whole genomic constellation of the first human G8 rotavirus strain detected in Japan.

    PubMed

    Agbemabiese, Chantal Ama; Nakagomi, Toyoko; Doan, Yen Hai; Nakagomi, Osamu

    2015-10-01

    Human G8 Rotavirus A (RVA) strains are commonly detected in Africa but are rarely detected in Japan and elsewhere in the world. In this study, the whole genome sequence of the first human G8 RVA strain designated AU109 isolated in a child with acute gastroenteritis in 1994 was determined in order to understand how the strain was generated including the host species origin of its genes. The genotype constellation of AU109 was G8-P[4]-I2-R2-C2-M2-A2-N2-T2-E2-H2. Phylogenetic analyses of the 11 genome segments revealed that its VP7 and VP1 genes were closely related to those of a Hungarian human G8P[14] RVA strain and these genes shared the most recent common ancestors in 1988 and 1982, respectively. AU109 possessed an NSP2 gene closely related to those of Chinese sheep and goat RVA strains. The remaining eight genome segments were closely related to Japanese human G2P[4] strains which circulated around 1985-1990. Bayesian evolutionary analyses revealed that the NSP2 gene of AU109 and those of the Chinese sheep and goat RVA strains diverged from a common ancestor around 1937. In conclusion, AU109 was generated through genetic reassortment event where Japanese DS-1-like G2P[4] strains circulating around 1985-1990 obtained the VP7, VP1 and NSP2 genes from unknown ruminant G8 RVA strains. These observations highlight the need for comprehensive examination of the whole genomes of RVA strains of less explored host species.

  14. Mushrooms and Health Summit proceedings.

    PubMed

    Feeney, Mary Jo; Dwyer, Johanna; Hasler-Lewis, Clare M; Milner, John A; Noakes, Manny; Rowe, Sylvia; Wach, Mark; Beelman, Robert B; Caldwell, Joe; Cantorna, Margherita T; Castlebury, Lisa A; Chang, Shu-Ting; Cheskin, Lawrence J; Clemens, Roger; Drescher, Greg; Fulgoni, Victor L; Haytowitz, David B; Hubbard, Van S; Law, David; Myrdal Miller, Amy; Minor, Bart; Percival, Susan S; Riscuta, Gabriela; Schneeman, Barbara; Thornsbury, Suzanne; Toner, Cheryl D; Woteki, Catherine E; Wu, Dayong

    2014-07-01

    The Mushroom Council convened the Mushrooms and Health Summit in Washington, DC, on 9-10 September 2013. The proceedings are synthesized in this article. Although mushrooms have long been regarded as health-promoting foods, research specific to their role in a healthful diet and in health promotion has advanced in the past decade. The earliest mushroom cultivation was documented in China, which remains among the top global mushroom producers, along with the United States, Italy, The Netherlands, and Poland. Although considered a vegetable in dietary advice, mushrooms are fungi, set apart by vitamin B-12 in very low quantity but in the same form found in meat, ergosterol converted with UV light to vitamin D2, and conjugated linoleic acid. Mushrooms are a rare source of ergothioneine as well as selenium, fiber, and several other vitamins and minerals. Some preclinical and clinical studies suggest impacts of mushrooms on cognition, weight management, oral health, and cancer risk. Preliminary evidence suggests that mushrooms may support healthy immune and inflammatory responses through interaction with the gut microbiota, enhancing development of adaptive immunity, and improved immune cell functionality. In addition to imparting direct nutritional and health benefits, analysis of U.S. food intake survey data reveals that mushrooms are associated with higher dietary quality. Also, early sensory research suggests that mushrooms blended with meats and lower sodium dishes are well liked and may help to reduce intakes of red meat and salt without compromising taste. As research progresses on the specific health effects of mushrooms, there is a need for effective communication efforts to leverage mushrooms to improve overall dietary quality. © 2014 American Society for Nutrition.

  15. The First National Pain Medicine Summit--final summary report.

    PubMed

    Lippe, Philipp M; Brock, Charles; David, Jose; Crossno, Ronald; Gitlow, Stuart

    2010-10-01

    and organizations dedicated to improving pain care, the first National Pain Medicine Summit. The process began with the adoption of Resolution 321 (A-08) at an AMA Annual House of Delegates meeting in June 2008. Resolution 321 (A-08) states, in part, that "...the AMA encourages relevant specialties to collaborate in studying: 1) the scope and practice and body of knowledge encompassed by the field of Pain Medicine; 2) the adequacy of undergraduate, graduate, and post graduate education in the principles and practices of the field of Pain Medicine, considering the current and anticipated medical need for the delivery of quality pain care; and 3) appropriate training and credentialing criteria for this multi-disciplinary field of medical practice." The next step was delegating the responsibility for implementing Resolution 321 (A-08) to the Pain and Palliative Medicine Specialty Section Council (PPMSSC). The PPMSSC, under the direction of its chairman, Philipp M. Lippe, MD, FACS, assumed responsibility in November 2008 for identifying a process that would achieve the goals established by Resolution 321 (A-08). The PPMSSC in turn established an Advisory Committee, charged with strategic planning, and an Implementation Committee, charged with tactical operations. The two groups began work immediately. The process included three distinct phases centered on a Pain Medicine Summit. Phase One involved a modified Delphi process identifying the five most pressing and relevant themes in pain care. Phase Two consisted of the Pain Medicine Summit itself, including a gathering of representatives from across the pain care spectrum to address the previously identified five most pressing themes. Phase Three was the preparation of this report, which describes the conclusions drawn and recommendations developed by the attendees at the Pain Medicine Summit. Based on a recommendation from the Advisory Committee, the PPMSSC decided to retain the services of a consulting firm to help the

  16. Fermi Large Area Telescope Observations of the Supernova Remnant G8.7-0.1

    SciTech Connect

    Ajello, M.; Allafort, A.; Baldini, L.; Ballet, J.; Barbiellini, G.; Bastieri, D.; Bechtol, K.; Bellazzini, R.; Berenji, B.; Blandford, R.D.; Bloom, E.D.; Bonamente, E.; Borgland, A.W.; Bregeon, J.; Brigida, M.; Bruel, P.; Buehler, R.; Buson, S.; Caliandro, G.A.; Cameron, R.A.; Caraveo, P.A.; /more authors..

    2012-09-14

    We present a detailed analysis of the GeV gamma-ray emission toward the supernova remnant (SNR) G8.7-0.1 with the Large Area Telescope (LAT) on board the Fermi Gamma-ray Space Telescope. An investigation of the relationship between G8.7-0.1 and the TeV unidentified source HESS J1804-216 provides us with an important clue on diffusion process of cosmic rays if particle acceleration operates in the SNR. The GeV gamma-ray emission is extended with most of the emission in positional coincidence with the SNR G8.7-0.1 and a lesser part located outside the western boundary of G8.7-0.1. The region of the gamma-ray emission overlaps spatially connected molecular clouds, implying a physical connection for the gamma-ray structure. The total gamma-ray spectrum measured with LAT from 200 MeV-100 GeV can be described by a broken power-law function with a break of 2.4 {+-} 0.6 (stat) {+-} 1.2 (sys) GeV, and photon indices of 2.10 {+-} 0.06 (stat) {+-} 0.10 (sys) below the break and 2.70 {+-} 0.12 (stat) {+-} 0.14 (sys) above the break. Given the spatial association among the gamma rays, the radio emission of G8.7-0.1, and the molecular clouds, the decay of p0s produced by particles accelerated in the SNR and hitting the molecular clouds naturally explains the GeV gamma-ray spectrum. We also find that the GeV morphology is not well represented by the TeV emission from HESS J1804-216 and that the spectrum in the GeV band is not consistent with the extrapolation of the TeV gamma-ray spectrum. The spectral index of the TeV emission is consistent with the particle spectral index predicted by a theory that assumes energy-dependent diffusion of particles accelerated in an SNR. We discuss the possibility that the TeV spectrum originates from the interaction of particles accelerated in G8.7-0.1 with molecular clouds, and we constrain the diffusion coefficient of the particles.

  17. International Summit 2014: Organisation of clinical ultrasound in the world.

    PubMed

    2014-12-01

    Ultrasound (US) is a widely used imaging modality throughout the world, yet differences in usage remain among countries or regions, according to the results of the International Summit, organised by the ESR during the European Congress of Radiology last March in Vienna. The International Summit is held each year by the ESR and its partner national and international societies of radiology from outside Europe with the primary goal of gathering information about a particular topic in radiology from a worldwide perspective. In 2014, some aspects of the practice of US imaging within and outside radiology were discussed, following a list of items prepared by the ESR Working Group on Ultrasound. Results showed that radiological US has similar problems throughout the world. At the same time, however, there are profound differences in how US is practised and the results of this meeting should be considered with caution. The results of the International Summit offer an overview of the major trends and differences in the use of US worldwide, but as a whole suggest that this imaging technique still plays a major role in radiology and health care.Main messages• US is a widely used modality and constitutes a great part of radiological workload.• The use of ultrasound is split between radiological and non-radiological services.• Training differs among countries and the presence of local subspecialty societies improves training quality.• The shortage of local radiologists and lack of interest among young radiologists are worrying.• US use should not be limited to radiologists alone, especially in sparsely populated areas.

  18. Cosmo-geo-anthropo-logical history and political and deep future events in climate and life evolution conveyed by a physical/virtual installation at a scale of 1 mm per 100 years across Denmark during the COP15 climate summit meeting.

    NASA Astrophysics Data System (ADS)

    Holm Jacobsen, Bo

    2010-05-01

    During the COP15 climate summit meeting a physical and virtual installation of time was performed at a linear scale of 1 mm per 100 years. The "track of time" was carefully anchored geographically so that highlights in time history coincided with landmarks of historical and cultural significance to both tourists and the local Danish population; with Big Bang at the site of early royal settlements from the Viking age (13.7 billion years ~ 137 km from now), Earth origin at Kronborg in Elsinore (4.6 bil. Years ~ 46 km), and fish go on land at The Little Mermaid (390 mil. Years ~ 3900 m). The venue of the COP15 meeting coincided with the position of severe global warming, driven by the steady solar constant increase, to be expected 600 million years into the future. Nested in this grand track of time were the Quaternary ice-ages (2.6 mil. years ~ 26 m), human origin as species (100,000 years ~ 1 m), human history (< 10,000 years ~ 100 mm), personal life and the scope of political consequences of voting action (100 years ~ 1 mm). This installation of time involved several media. Highlights in time history and future were installed as a kml-file so that the convenient user interface of Google Earth could be utilized to provide both overview of time and understanding of details and proportions events antropo-geo-cosmo-history. Each Google Earth marker-balloon gave short explanations and linked to "on location" video-narratives. A classical printed text-folder was prepared as a tour guide for those who wanted to actually walk the Phanerozoic (~5 km). Credit-card-shaped graphs of temperature, CO2 and sealevel development and scenarios were prepared to scale for the period 4000 BP to 1000 years into the future. Along the time line from "Fish on land" to the present 3900 chalk marks were placed on the street surface, one for every metre = time span of Man as a species so far. A "NowGate" marking the present was implemented physically as a door frame, where citizens could meet

  19. Energy - Water Nexus -- Meeting the Energy and Water Needs of the Snake/Columbia River Basin in the 21st CenturyScience and Technology SummitConference Results

    SciTech Connect

    Paul L. Wichlacz; Gerald Sehlke

    2008-02-01

    In June 2007, representatives from federal, state, and academic institutions met to discuss the role of innovative science, technology, and policy in meeting future energy and water demands in the Snake-Columbia River Basin. Conference members assessed the state-of-the-science, technology, and associated research to develop cost-effective and environmentally sound methodologies and technologies to maximize the production of energy and availability of water and to minimize the consumption of both water and energy in the Snake-Columbia River system. Information on all phases of science and technology development, theoretical analysis, laboratory experiments, pilot tests, and field applications were relevant topics for discussion. An overview of current management needs was presented the first day. On the second day, five focus groups were created: ? Energy Generation and Use ? Water Allocation and Use ? Energy/Water Storage ? Environmental Considerations ? Social, Economic, Political, and Regulatory Considerations. Each group started with a list of status items and trends, and discussed the future challenges and research needed to reach four goals: ? Balance energy production and resource consumption ? Balance water availability and competing needs ? Balance water consumption/energy production and competing needs ? Balance environmental impacts and water use/energy production ? Balance costs and benefits of water use. The resulting initiatives were further broken down into three categories of importance: critical, important, and nice to do but could be delayed. Each initiative was assigned a number of dots to show a more refined ranking. The results of each focus group are given in the pages that follow. These results are intended to help local and regional researchers 1. Develop a technical strategy for developing cost-effective science and technology to predict, measure, monitor, purify, conserve, and store water and to maximize power generation, storage, and

  20. Definitive care for the critically ill during a disaster: medical resources for surge capacity: from a Task Force for Mass Critical Care summit meeting, January 26-27, 2007, Chicago, IL.

    PubMed

    Rubinson, Lewis; Hick, John L; Curtis, J Randall; Branson, Richard D; Burns, Suzi; Christian, Michael D; Devereaux, Asha V; Dichter, Jeffrey R; Talmor, Daniel; Erstad, Brian; Medina, Justine; Geiling, James A

    2008-05-01

    Mass numbers of critically ill disaster victims will stress the abilities of health-care systems to maintain usual critical care services for all in need. To enhance the number of patients who can receive life-sustaining interventions, the Task Force on Mass Critical Care (hereafter termed the Task Force) has suggested a framework for providing limited, essential critical care, termed emergency mass critical care (EMCC). This article suggests medical equipment, concepts to expand treatment spaces, and staffing models for EMCC. Consensus suggestions for EMCC were derived from published clinical practice guidelines and medical resource utilization data for the everyday critical care conditions that are anticipated to predominate during mass critical care events. When necessary, expert opinion was used. TASK FORCE MAJOR SUGGESTIONS: The Task Force makes the following suggestions: (1) one mechanical ventilator that meets specific characteristics, as well as a set of consumable and durable medical equipment, should be provided for each EMCC patient; (2) EMCC should be provided in hospitals or similarly equipped structures; after ICUs, postanesthesia care units, and emergency departments all reach capacity, hospital locations should be repurposed for EMCC in the following order: (A) step-down units and large procedure suites, (B) telemetry units, and (C) hospital wards; and (3) hospitals can extend the provision of critical care using non-critical care personnel via a deliberate model of delegation to match staff competencies with patient needs. By using the Task Force suggestions for adequate supplies of medical equipment, appropriate treatment space, and trained staff, communities may better prepare to deliver augmented essential critical care in response to disasters.

  1. Manganese G8 Dendrimers Targeted to Oxidation-Specific Epitopes: In vivo MR imaging of Atherosclerosis

    PubMed Central

    Nguyen, Tuyen H.; Bryant, Henry; Shapsa, Ari; Street, Hannah; Mani, Venkatesh; Fayad, Zahi A.; Frank, Joseph A.; Tsimikas, Sotirios; Briley-Saebo, Karen C.

    2014-01-01

    Objective To determine if manganese (Mn) G8 dendrimers targeted to oxidation-specific epitopes (OSE) allow for in vivo detection of atherosclerotic lesions. Background OSE have been identified as key factors in atherosclerotic plaque progression and destabilization. Mn offers a potentially clinically translatable alternative to gadolinium-based agents when bioretention and potential toxicity of gadolinium is anticipated. However, to be effective, high payloads of Mn must accumulate intracellularly in macrophages. It was hypothesized that G8 dendrimers targeted to OSE may allow delivery of high Mn payloads, thereby enabling in vivo detection of macrophage rich plaques. Methods G8 dendrimers were modified to allow conjugation with MnDTPA (758 Mn ion) and the antibody MDA2 that is targeted to malondialdehyde (MDA)-lysine epitopes. Both the untargeted and targeted G8 dendrimers were characterized and their in vivo efficacy evaluated in apoE-/- mice over a 96-hour time period after bolus administration of a 0.05 mmol Mn/kg dose using a clinical MR system (3 Tesla). Results Significant enhancement (normalized enhancement >60%, p=0.0013) of atherosclerotic lesions was observed within a 72-hour time period following administration of the targeted dendrimers. The presence of Mn within atherosclerotic lesions was confirmed using spectroscopic methods (>8 μg Mn/g). Limited signal attenuation (<18%) and Mn deposition (< 1 μg Mn/g) was observed in the arterial wall following injection of the untargeted material. Conclusions This study demonstrates that manganese labeled dendrimers, allowing a high Mn payload, targeted to OSE may allow in vivo image of atherosclerotic lesions. PMID:24610640

  2. Isolation of serotype G8, P6[1] bovine rotavirus from adult cattle with diarrhea.

    PubMed Central

    Sato, M; Nakagomi, T; Tajima, K; Ezura, K; Akashi, H; Nakagomi, O

    1997-01-01

    Two electrophoretically identical strains of group A rotavirus were isolated from diarrheic cows aged 3, 4, and 7 years on a dairy farm in Japan. They had a rare serotype combination of G8 and P6[1] and were shown by RNA-RNA hybridization to be most closely related to bovine strain NCDV-Lincoln (G6P6[1]). PMID:9114422

  3. Rehabilitation Medicine Summit: building research capacity.

    PubMed

    Frontera, Walter R; Fuhrer, Marcus J; Jette, Alan M; Chan, Leighton; Cooper, Rory A; Duncan, Pamela W; Kemp, John D; Ottenbacher, Kenneth J; Peckham, P Hunter; Roth, Elliot J; Tate, Denise G

    2005-12-01

    The general objective of the "Rehabilitation Medicine Summit: Building Research Capacity" was to advance and promote research in medical rehabilitation by making recommendations to expand research capacity. The five elements of research capacity that guided the discussions were: 1) researchers; 2) research culture, environment, and infrastructure; 3) funding; 4) partnerships; and 5) metrics. The 100 participants included representatives of professional organizations, consumer groups, academic departments, researchers, governmental funding agencies, and the private sector. The small group discussions and plenary sessions generated an array of problems, possible solutions, and recommended actions. A post-Summit, multi-organizational initiative is called for to pursue the agendas outlined in this report.

  4. Rehabilitation Medicine Summit: Building Research Capacity

    PubMed Central

    Frontera, Walter R; Fuhrer, Marcus J; Jette, Alan M; Chan, Leighton; Cooper, Rory A; Duncan, Pamela W; Kemp, John D; Ottenbacher, Kenneth J; Peckham, P Hunter; Roth, Elliot J; Tate, Denise G

    2006-01-01

    Summary: The general objective of the “Rehabilitation Medicine Summit: Building Research Capacity” was to advance and promote research in medical rehabilitation by making recommendations to expand research capacity. The five elements of research capacity that guided the discussions were: 1) researchers; 2) research culture, environment, and infrastructure; 3) funding; 4) partnerships; and 5) metrics. The 100 participants included representatives of professional organizations, consumer groups, academic departments, researchers, governmental funding agencies, and the private sector. The small group discussions and plenary sessions generated an array of problems, possible solutions, and recommended actions. A post-Summit, multi-organizational initiative is called to pursue the agendas outlined in this report. PMID:16572568

  5. Summit of the Research Coordination Networks for Undergraduate Biology Education

    PubMed Central

    Eaton, Carrie Diaz; Allen, Deborah; Anderson, Laurel J.; Bowser, Gillian; Pauley, Mark A.; Williams, Kathy S.; Uno, Gordon E.

    2016-01-01

    The first summit of projects funded by the National Science Foundation’s Research Coordination Networks for Undergraduate Biology Education (RCN-UBE) program was held January 14–16, 2016, in Washington, DC. Sixty-five scientists and science educators from 38 of the 41 Incubator and Full RCN-UBE awards discussed the value and contributions of RCNs to the national biology education reform effort. The summit illustrated the progress of this innovative UBE track, first awarded in 2009. Participants shared experiences regarding network development and growth, identified best practices and challenges faced in network management, and discussed work accomplished. We report here on key aspects of network evaluation, characteristics of successful networks, and how to sustain and broaden participation in networks. Evidence from successful networks indicates that 5 years (the length of a Full RCN-UBE) may be insufficient time to produce a cohesive and effective network. While online communication promotes the activities of a network and disseminates effective practices, face-to-face meetings are critical for establishing ties between network participants. Creation of these National Science Foundation–funded networks may be particularly useful for consortia of faculty working to address problems or exchange novel solutions discovered while introducing active-learning methods and/or course-based research into their curricula.

  6. Galapagos III World Evolution Summit: why evolution matters.

    PubMed

    Paz-Y-Miño-C, Guillermo; Espinosa, Avelina

    There is no place on Earth like the Galapagos Islands and no better destination to discuss the reality of evolution. Under the theme 'Why Does Evolution Matter', the University San Francisco of Quito (USFQ), Ecuador, and its Galapagos Institute for the Arts and Sciences (GAIAS), organized the III World Evolution Summit in San Cristóbal Island. The 200-attendee meeting took place on 1 to 5 June 2013; it included 12 keynote speakers, 20 oral presentations by international scholars, and 31 posters by faculty, postdocs, and graduate and undergraduate students. The Summit encompassed five sessions: evolution and society, pre-cellular evolution and the RNA world, behavior and environment, genome, and microbes and diseases. USFQ and GAIAS launched officially the Lynn Margulis Center for Evolutionary Biology and showcased the Galapagos Science Center, in San Cristóbal, an impressive research facility conceptualized in partnership with the University of North Carolina at Chapel Hill, USA. USFQ and GAIAS excelled at managing the conference with exceptional vision and at highlighting the relevance of Galapagos in the history of modern evolutionary thinking; Charles Darwin's visit to this volcanic archipelago in 1835 unfolded unprecedented scientific interest in what today is a matchless World Heritage.

  7. Galapagos III World Evolution Summit: why evolution matters

    PubMed Central

    Paz-y-Miño-C, Guillermo; Espinosa, Avelina

    2016-01-01

    There is no place on Earth like the Galapagos Islands and no better destination to discuss the reality of evolution. Under the theme ‘Why Does Evolution Matter’, the University San Francisco of Quito (USFQ), Ecuador, and its Galapagos Institute for the Arts and Sciences (GAIAS), organized the III World Evolution Summit in San Cristóbal Island. The 200-attendee meeting took place on 1 to 5 June 2013; it included 12 keynote speakers, 20 oral presentations by international scholars, and 31 posters by faculty, postdocs, and graduate and undergraduate students. The Summit encompassed five sessions: evolution and society, pre-cellular evolution and the RNA world, behavior and environment, genome, and microbes and diseases. USFQ and GAIAS launched officially the Lynn Margulis Center for Evolutionary Biology and showcased the Galapagos Science Center, in San Cristóbal, an impressive research facility conceptualized in partnership with the University of North Carolina at Chapel Hill, USA. USFQ and GAIAS excelled at managing the conference with exceptional vision and at highlighting the relevance of Galapagos in the history of modern evolutionary thinking; Charles Darwin’s visit to this volcanic archipelago in 1835 unfolded unprecedented scientific interest in what today is a matchless World Heritage. PMID:26925190

  8. Context view shows approach of access road to summit, communication ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Context view shows approach of access road to summit, communication towers and NW corner of lookout tower at center right. Camera is pointed SE. - Chelan Butte Lookout, Summit of Chelan Butte, Chelan, Chelan County, WA

  9. Air quality real-time forecast before and during the G-20 Summit 2016 in Hangzhou with the WRF-CMAQ and WRF/Chem systems: Evaluation and Emission Reduction Effects

    EPA Science Inventory

    The 2016 G-20 Hangzhou summit, the eleventh annual meeting of the G-20 heads of government, will be held during September 3-5, 2016 in Hangzhou, China. For a successful summit, it is important to ensure good air quality. To achieve this goal, governments of Hangzhou and its surr...

  10. Air quality real-time forecast before and during the G-20 Summit 2016 in Hangzhou with the WRF-CMAQ and WRF/Chem systems: Evaluation and Emission Reduction Effects

    EPA Science Inventory

    The 2016 G-20 Hangzhou summit, the eleventh annual meeting of the G-20 heads of government, will be held during September 3-5, 2016 in Hangzhou, China. For a successful summit, it is important to ensure good air quality. To achieve this goal, governments of Hangzhou and its surr...

  11. Social Summit 1995: Putting Literacy on the Agenda.

    ERIC Educational Resources Information Center

    ASPBAE Courier, 1994

    1994-01-01

    This theme issue contains 10 articles related to core issues of the World Summit for Social Development in Copenhagen in March 1995. "Social Summit, People, and Education" (Om Shrivastava) addresses the summit's focuses: elimination of poverty, reduction of unemployment, and social integration. "Education for All by the Year…

  12. Rehabilitation Medicine Summit: Building Research Capacity

    ERIC Educational Resources Information Center

    Frontera, Walter R.; Fuhrer, Marcus J.; Jette, Alan M.; Chan, Leighton; Cooper, Rory A.; Duncan, Pamela W.; Kemp, John D.; Ottenbacher, Kenneth J.; Peckham, P. Hunter; Roth, Elliot J.; Tate, Denise G.

    2006-01-01

    The general objective of the "Rehabilitation Medicine Summit: Building Research Capacity" was to advance and promote research in medical rehabilitation by making recommendations to expand research capacity. The 5 elements of research capacity that guided the discussions were (a) researchers; (b) research culture, environment, and infrastructure;…

  13. Summit firn caves, mount rainier, washington.

    PubMed

    Kiver, E P; Mumma, M D

    1971-07-23

    Heat and steam from the crater fumaroles have melted over 5700 feet (1737 meters) of cave passage in the ice-filled east crater of Mount Rainier. The caves are in approximate balance with the present geothermal heat release. Future changes in the thermal activity of the summit cone will cause corresponding changes in cave passage dimensions, location, and ceiling and wall ablation features.

  14. Proceedings of the Great Lakes silviculture summit

    Treesearch

    Brian Palik; Louise (ed.) Levy

    2004-01-01

    The goal of the Great Lakes Silviculture Summit was to identify a research agenda that captures the priority information needs of diverse organizations in the region. These needs and the resultant research agenda are presented in the series of papers in these proceedings.

  15. The Cancer Moonshot Summit: Reaching New Heights

    Cancer.gov

    An NCI Cancer Currents blog from acting NCI Director Dr. Doug Lowy on the Cancer Moonshot national summit hosted by Vice President Joe Biden in Washington, D.C., including a summary of the NCI-related activities stimulated by the Cancer Moonshot.

  16. 5th Antiviral Drug Discovery and Development Summit.

    PubMed

    Blair, Wade; Perros, Manos

    2004-08-01

    The 5th Antiviral Drug Discovery and Development Summit provided an up-to-date snapshot of the ongoing developments in the area. The topics covered ranged from updates on recently launched drugs (Kaletra), Fuzeon) and new investigational inhibitors (T-1249, Reverset, UK-427857, L-870810, PA-457, remofovir, VX-950), to the discovery of new antiviral targets and advances in technologies that may provide the substrate for the next generation of therapeutics. It is apparent from the range of presentations that much of today's efforts are focused on developing new classes of HIV inhibitors (gp41, integrase), while there is also considerable progress in hepatitis C, where a number of inhibitors have or should reach proof-of-concept studies in the coming months. Here we provide the highlights of this meeting, with particular emphasis on the new developments in HIV and hepatitis C virus.

  17. International concerted action on collaboration in telemedicine: G8 sub-project 4.

    PubMed

    Lacroix, A

    1999-01-01

    The main objective of G-7/8 Global Healthcare Applications sub-project 4 is to enable an international concerted action on collaboration in telemedicine. To promote and facilitate the implementation of telemedicine or health telematics networks around the world, it was felt necessary to solve certain key issues. Five thematic solution-seeking FORUMS are each addressing a specific item. The first FORUM held in Montréal, Canada on May 28-30 1998 focussed on Interoperability of telemedicine and telehealth systems. Other FORUMS address other themes such as: Impacts of Telemedicine on health care management (Regensburg, Germany, November 21-23 1998); Evaluation and Cost Effectiveness of Telemedicine (Melbourne, Australia, February 19-20 1999); Clinical and technical quality and standards (Washington, USA, April 29-30 1999); Medico-legal aspects of national and international applications (Oxford, UK, fall 1999). The main objective of these FORUMS is to arrive at best practices through consultation amongst experts who seek together the best solutions to facilitate global international telemedicine networks. Towards this goal, G-8 sub-project-4 will also conduct the IMPACT (International Multipoint Project of Advanced Communication in Telemedicine) feasibility study which will aim at conducting multipoint exchanges between telemedicine units in the academic centers of the participating G-8 and other countries. More detailed information on this project and summaries of the initial FORUMS are found on our Web site at www.g7sp4.org.

  18. Origin of mutational effects at the C3 and G8 positions on hammerhead ribozyme catalysis from molecular dynamics simulations.

    PubMed

    Lee, Tai-Sung; York, Darrin M

    2008-06-11

    A series of ten 60 ns molecular dynamics (MD) simulations of the native and mutated full length hammerhead ribozymes in the reactant state and in an activated precursor state (G8:2'OH deprotonated) are reported. Mutant simulations include the C3U, G8A, and G8I single mutants and a C3U/G8A double mutant that exhibits an experimental rescue effect. The results provide critical details into the origin of the observed mutation effects and support a mechanism where the 2'OH of G8 acts as a general acid catalyst that is held in position through Watson-Crick hydrogen bonding between G8 and C3.

  19. Efficient Mobility Summit: Transportation and the Future of Dynamic Mobility Systems

    SciTech Connect

    2015-12-01

    On October 27, 2015, The U.S. Department of Energy's National Renewable Energy Laboratory (NREL) brought together local and national thought leaders to discuss the convergence of connectivity, vehicle automation, and transportation infrastructure investments at the Future Energy Efficient Mobility Workshop. The half-day workshop was held in conjunction with the Colorado Department of Transportation's (CDOT) Transportation Matters Summit and featured four panel sessions that showcased perspectives on efficient mobility from federal and state agencies, automakers and their suppliers, transportation data providers, and freight companies. This summary provides highlights from the meeting's exchanges of ideas and existing applications. Transportation's (CDOT) Transportation Matters Summit and featured four panel sessions that showcased perspectives on efficient mobility from federal and state agencies, automakers and their suppliers, transportation data providers, and freight companies. This summary provides highlights from the meeting's exchanges of ideas and existing applications.

  20. Current research in aging: a report from the 2015 Ageing Summit.

    PubMed

    Moyse, Emmanuel; Lahousse, Lies; Krantic, Slavica

    2015-01-01

    Ageing Summit, London, UK, 10-12 February 2015 The Ageing Summit 2015 held on 10-12 February 2015 in London (UK) provided an extensive update to our knowledge of the 'Biology of Ageing' and a forum to discuss the participants' latest research progress. The meeting was subdivided into four thematic sessions: cellular level research including the aging brain; slowing down progression, rejuvenation and self-repair; genetic and epigenetic regulation; and expression and pathology of age-related diseases. Each session included multiple key presentations, three to five short research communications and ongoing poster presentations. The meeting provided an exciting multidisciplinary overview of the aging process from cellular and molecular mechanisms to medico-social aspects of human aging.

  1. The 2015 Chile-U.S. Astronomy Education Outreach Summit in Chile

    NASA Astrophysics Data System (ADS)

    Preston, Sandra Lee; Arnett, Dinah; Hardy, Eduardo; Cabezón, Sergio; Spuck, Tim; Fields, Mary Sue; Smith, R. Chris

    2015-08-01

    The first Chile-U.S. Astronomy Education Outreach Summit occurred March 22-28, 2015. The Summit was organized and supported by the U.S. Embassy in Chile, Associated Universities Inc., Association of Universities for Research in Astronomy, the Carnegie Institution for Science, the Image of Chile Foundation, the National Science Foundation, and La Comisión Nacional de Investigación Científica y Tecnológica. The Summit brought together a team of leading experts and officials from Chile and the U.S. to share best practices in astronomy education and outreach. In addition, Summit participants discussed enhancing existing partnerships, and building new collaborations between U.S. Observatories and astronomy education outreach leaders in Chile.The Summit was an exciting and intense week of work and travel. Discussions opened in Santiago on March 22 with a variety of astronomy education and public outreach work sessions, a public forum, and on March 23 the U.S. Embassy sponsored a Star Party. On Tuesday, March 24, the Summit moved to San Pedro de Atacama, where activities included work sessions, a visit to the Atacama Large Millimeter/Submillimeter Array telescope facilities, and a second public forum. From San Pedro, the team traveled to La Serena for additional work sessions, visits to Gemini and Cerro Tololo, a third public forum, and the closing session. At each stop, authorities and the broader community were invited to participate and provide valuable input on the current state, and the future, of astronomy education and public outreach.Following the Summit a core working committee has continued meeting to draft a “roadmap document” based on findings from the Summit. This document will help to identify potential gaps in astronomy outreach efforts, and how the U.S. facilities and Chilean institutions might work together strategically to address these needs. The first draft of this “roadmap document” will be made available for comment in both Spanish and

  2. 77 FR 36549 - Nursing Workforce Diversity Invitational Summit-“Nursing in 3D: Workforce Diversity, Health...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-19

    ... HUMAN SERVICES Health Resources and Services Administration Nursing Workforce Diversity Invitational Summit--``Nursing in 3D: Workforce Diversity, Health Disparities, and Social Determinants of Health...). ACTION: Notice of meeting. SUMMARY: HRSA's Bureau of Health Professions, Division of Nursing, will host...

  3. National Summit on Innovation and Learning=Sommet National sur L'Innovation et L'Apprentissage. Summary=Sommaire.

    ERIC Educational Resources Information Center

    Conference Board of Canada, Ottawa (Ontario).

    This report provides a summary of the objectives, proceedings, and major outcomes of a summit meeting of over 500 leaders from across Canada convened to validate and prioritize strategic recommendations from an innovation and learning engagement process and to discuss key challenges to realization of Canada's vision to become one of the most…

  4. Improving the health status of Caribbean people: recommendations from the Triangulating on Health Equity summit.

    PubMed

    Sastre, Francisco; Rojas, Patria; Cyrus, Elena; De La Rosa, Mario; Khoury, Aysha H

    2014-09-01

    In 2011, Morehouse School of Medicine convened a summit in San Juan, Puerto Rico, to discuss issues related to the health status of people and communities in the Caribbean region. The summit provided a forum for transparent dialog among researchers, policymakers, and advocates from the Caribbean region and the United States. The summit's theme-improving the region's health outcomes through the adoption of effective practices linking health promotion and primary care, within the context of social and cultural determinants-called for a comprehensive and integrative model or a triangulation of methodologies to improve health outcomes. This article summarizes the recommendations of two workgroup sessions examining the challenges to improving health outcomes in the region and the opportunities to meet those challenges. The recommendations seek to develop action-oriented agendas that integrate research, practice, and policy. Outcomes of the summit highlight the importance of (a) community participation in planning interventions, (b) policymakers' commitment to prioritizing health, and (c) Caribbean governments' commitment to addressing the underlying social factors responsible for poor health outcomes.

  5. Global Summit on Regulatory Science 2013.

    PubMed

    Howard, Paul C; Tong, Weida; Weichold, Frank; Healy, Marion; Slikker, William

    2014-12-01

    Regulatory science has been defined as the science that is used to develop regulatory decisions by government bodies. Regulatory science encompasses many scientific disciplines that oversee many studies producing a wide array of data. These may include fundamental research into the cellular interaction or response to a particular chemical or substance, hazard-assessment and dose-response studies in animal species, neurophysiological or neurobehavioral studies, best practices for the generation and analysis of genomics data, bioinformatics approaches, and mathematical modeling of risk. The Global Summit on Regulatory Science is an international conference with a mission to explore emerging and innovative technologies, and provide a platform to enhance translation of basic science into regulatory applications. The Third Global Summit on Regulatory Science which focused on nanotechnology is discussed.

  6. Comparative Indicators of Education in the United States and Other G-8 Countries: 2006. NCES 2007-006

    ERIC Educational Resources Information Center

    Miller, David C.; Sen, Anindita; Malley, Lydia B.

    2007-01-01

    This report describes how the education system in the United States compares with education systems in the other Group of Eight (G-8) countries. The G-8 countries--Canada, France, Germany, Italy, Japan, the Russian Federation, the United Kingdom, and the United States--are among the world's most economically developed countries. Comparative…

  7. NATO’s Warsaw Summit: In Brief

    DTIC Science & Technology

    2016-11-14

    fighting in Ukraine. Russia’s actions in Ukraine and Eastern Europe more broadly have upended NATO’s post- Cold War transformation from a military...as the biggest reinforcement of NATO’s collective defense since the end of the Cold War. At the Wales summit, the allies agreed to a Readiness...particularly in sensitive areas such as cyber policy. Despite the fact that they have 22 members in common , NATO and the EU have historically

  8. Thermal conductivity measurements of Summit polycrystalline silicon.

    SciTech Connect

    Clemens, Rebecca; Kuppers, Jaron D.; Phinney, Leslie Mary

    2006-11-01

    A capability for measuring the thermal conductivity of microelectromechanical systems (MEMS) materials using a steady state resistance technique was developed and used to measure the thermal conductivities of SUMMiT{trademark} V layers. Thermal conductivities were measured over two temperature ranges: 100K to 350K and 293K to 575K in order to generate two data sets. The steady state resistance technique uses surface micromachined bridge structures fabricated using the standard SUMMiT fabrication process. Electrical resistance and resistivity data are reported for poly1-poly2 laminate, poly2, poly3, and poly4 polysilicon structural layers in the SUMMiT process from 83K to 575K. Thermal conductivity measurements for these polysilicon layers demonstrate for the first time that the thermal conductivity is a function of the particular SUMMiT layer. Also, the poly2 layer has a different variation in thermal conductivity as the temperature is decreased than the poly1-poly2 laminate, poly3, and poly4 layers. As the temperature increases above room temperature, the difference in thermal conductivity between the layers decreases.

  9. A Spectral-line Analysis of the G8 III Standard ɛ VIR

    NASA Astrophysics Data System (ADS)

    Gray, David F.

    2017-08-01

    Eleven seasons of spectroscopic data comprised of 107 exposures for the stable G8 III standard star, ɛ Vir are analyzed for projected rotation rate and granulation parameters. A Fourier analysis of the line shapes yield v sin i = 3.06 ± 0.20 km s-1 and a radial-tangential macroturbulence dispersion ζ RT = 5.16 ± 0.08 km s-1. The radial velocity over nine seasons is constant to 18 m s-1. The absolute radial velocity with granulation blueshifts (but not gravitational redshift) removed is -14120 ± 75 m s-1. Line-depth ratios show the temperature to be constant to 0.7 K over 11 years, although a small secular rise or cyclic variation ˜1 K cannot be ruled out. The third-signature plot shows that the star has granulation velocities 10% larger than the Sun's. Mapping the Fe i λ6253 line bisector on to the third-signature plot indicates a normal-for-giants flux deficit area of 12.8%, indicating ˜134 K temperature difference between granules and lanes. Deficit velocities of GK giants are seen to shift to higher values with higher luminosity, ˜0.75 km s-1 over ΔM V ˜ 1.5, indicating larger velocity differences between granules and lanes for giants higher in the HR diagram.

  10. Chromosome jumping from D4S10 (G8) toward the Huntington disease gene.

    PubMed Central

    Richards, J E; Gilliam, T C; Cole, J L; Drumm, M L; Wasmuth, J J; Gusella, J F; Collins, F S

    1988-01-01

    The gene for Huntington disease (HD) has been localized to the distal portion of the short arm of human chromosome 4 by linkage analysis. Currently, the two closest DNA markers are D4S10 (G8), located approximately equal to 3 centimorgans centromeric to HD, and D4S43 (C4H), positioned 0-1.5 centimorgans from HD. In an effort to move closer to the HD gene, with the eventual goal of identifying the gene itself, we have applied the technique of chromosome jumping to this region. A 200-kilobase jumping library has been constructed, and a jump from D4S10 has been obtained and its approximate distance verified by pulsed field gel electrophoresis. Two restriction fragment length polymorphisms have been identified at the jump locus, which is denoted D4S81. Linkage analysis of previously identified recombinants between D4S10 and HD or D4S10 and D4S43 shows that in two of five events the jump has crossed the recombination points. This unequivocally orients D4S10 and D4S81 on the chromosome, provides additional markers for HD, and suggests that recombination frequency in this region of chromosome 4 may be increased, so that the physical distance from D4S10 to HD may not be as large as originally suspected. Images PMID:2901098

  11. WASP-41b: A Transiting Hot Jupiter Planet Orbiting a Magnetically Active G8V Star

    NASA Astrophysics Data System (ADS)

    Maxted, P. F. L.; Anderson, D. R.; Collier Cameron, A.; Hellier, C.; Queloz, D.; Smalley, B.; Street, R. A.; Triaud, A. H. M. J.; West, R. G.; Gillon, M.; Lister, T. A.; Pepe, F.; Pollacco, D.; Ségransan, D.; Smith, A. M. S.; Udry, S.

    2011-05-01

    We report the discovery of a transiting planet with an orbital period of 3.05 days orbiting the star TYC 7247-587-1. The star, WASP-41, is a moderately bright G8 V star (V = 11.6) with a metallicity close to solar ([Fe/H] = -0.08 ± 0.09). The star shows evidence of moderate chromospheric activity, both from emission in the cores of the Ca ii H and K ines and photometric variability with a period of 18.4 days and an amplitude of about 1%. We use a new method to show quantitatively that this periodic signal has a low false-alarm probability. The rotation period of the star implies a gyrochronological age for WASP-41 of 1.8 Gyr with an error of about 15%. We have used a combined analysis of the available photometric and spectroscopic data to derive the mass and radius of the planet (0.92 ± 0.06 MJup, 1.20 ± 0.06 RJup). Further observations of WASP-41 can be used to explore the connections between the properties of hot Jupiter planets and the level of chromospheric activity in their host stars.

  12. NATO’s Wales Summit: Expected Outcomes and Key Challenges

    DTIC Science & Technology

    2014-08-26

    NATO’s Wales Summit : Expected Outcomes and Key Challenges Paul Belkin Analyst in European Affairs August 26, 2014 Congressional Research...control number. 1. REPORT DATE 26 AUG 2014 2. REPORT TYPE 3. DATES COVERED 00-00-2014 to 00-00-2014 4. TITLE AND SUBTITLE NATO’s Wales Summit ...Rev. 8-98) Prescribed by ANSI Std Z39-18 NATO’s Wales Summit : Expected Outcomes and Key Challenges Congressional Research Service Summary On

  13. 77 FR 68117 - Blue Summit Wind, LLC; Notice of Petition for Declaratory Order

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-15

    ... Energy Regulatory Commission Blue Summit Wind, LLC; Notice of Petition for Declaratory Order Take notice... (Commission) Rules of Practice and Procedure 18 CFR 385.207(a)(2), Blue Summit Wind, LLC (Blue Summit) filed a...) interconnection facilities that deliver power from the Blue Summit's wind energy generator (Blue Summit...

  14. From the Earth Summit to Rio+20: integration of health and sustainable development.

    PubMed

    Haines, Andy; Alleyne, George; Kickbusch, Ilona; Dora, Carlos

    2012-06-09

    In 2012, world leaders will meet at the Rio+20 conference to advance sustainable development--20 years after the Earth Summit that resulted in agreement on important principles but insufficient action. Many of the development goals have not been achieved partly because social (including health), economic, and environmental priorities have not been addressed in an integrated manner. Adverse trends have been reported in many key environmental indicators that have worsened since the Earth Summit. Substantial economic growth has occurred in many regions but nevertheless has not benefited many populations of low income and those that have been marginalised, and has resulted in growing inequities. Variable progress in health has been made, and inequities are persistent. Improved health contributes to development and is underpinned by ecosystem stability and equitable economic progress. Implementation of policies that both improve health and promote sustainable development is urgently needed.

  15. Summit geomorphology of western Pacific guyots

    NASA Astrophysics Data System (ADS)

    Van Waasbergen, Robert J.; Winterer, Edward L.

    Bathymetric and seismic reflection data for 21 guyots in the Japanese, Wake and Mid Pacific Mountains seamount groups show that many guyots bear thick shallow-water limestone deposits that represent nearly undeformed Cretaceous rudist-reef-bounded carbonate platforms. Three types of guyot summits are distinguished: those with more than 200 m of shallow-water limestone, sufficient to bury the underlying volcanic relief, follow the same basic morphologic patterns as their coral/algal-dominated modern counterparts. Surface morphology is controlled by the original reef/platform configuration, modified by subaerial erosion and by long-term deformation of the sedimentary deposits and the underlying volcanic edifice. These seamounts range in age from Barremian to Aptian, with Barremian or Aptian to late Albian limestone deposits. Guyots with thin limestone deposits represent reef-bearing volcanic islands at various stages of fringing-reef and barrier-reef development. These edifices and their overlying limestone deposits are of Albian age. Reef growth on these was suddenly halted when regional emergence led to cessation of shallow-water-limestone accumulation on all guyots in the western Pacific, probably during the latest Albian. The karstic surfaces were resubmerged by middle Turonian time and, in latitudes south of about 20°N, blanketed by pelagic ooze. Guyots without reef deposits appear to be products of post-Albian volcanism and erosion at sea level. Among the three types of summit-configurations a range of stages of development of Cretaceous carbonate-platforms can be observed. The exposure of the guyot summits indicated by the occurence of karstic relief of 100-200 m on many of the limestone caps suggests that the sea floor of the western Pacific was raised several hundred meters. The age and platform thickness-relationships among the different types of guyots suggests that this uplift occurred at late Albian time.

  16. Detection and Whole-Genome Characterization of a G8P[1] Group A Rotavirus Strain from Deer

    PubMed Central

    Peterson, Jessica

    2016-01-01

    Rotavirus A strain 14-02218-2, with genome constellation G8P[1]-I2-R2-C2-M2-A3-N2-T6-E2-H3, was isolated from newborn fawns. The 14-02218-2 rotavirus strain is related to bovine and bovine-like rotavirus strains. To our knowledge, this is the first report on whole-genome-based characterization of a deer rotavirus G8P[1] strain. PMID:27932644

  17. Athletic Training and Public Health Summit.

    PubMed

    Hoffman, Mark; Bovbjerg, Viktor; Hannigan, Kim; Hootman, Jennifer M; Johnson, Sam T; Kucera, Kristen L; Norcross, Marc F

    2016-07-01

    To introduce athletic trainers to the benefits of using a population-based approach to injury and illness prevention and to explore opportunities for partnering with public health professionals on these initiatives. Athletic trainers play leading roles in individual injury and illness prevention but are less familiar with policy development, evaluation, and implementation from a population-level standpoint. The Athletic Training and Public Health Summit was convened to understand, explore, and develop the intersection of athletic training and public health. To further the integration of athletic training within the public health arena, athletic trainers must expand their professional focus beyond the individual to the population level.

  18. The G8-global healthcare applications project (GHAP) - recommendations for the way into the information society

    PubMed

    Dietzel

    1999-12-16

    The Global Healthcare Applications Project has sought to demonstrate the potential of telematics in the field of medicine and healthcare and to promote joint approaches to issues such as the setting of standards. This has been done through 10 sub-projects covering a range of applications and issues: 1. Towards a global public health information network - Coordinator: Germany (Ulrich Laaser, ulaaser@mail.uni-bielefeld.de; URL: http://health.ibs.uni-bielefeld. de/i-jphe/database/documents/abstract/laaser-g7.htm(C45-60_laaser-g7. pdf) 2. Improving prevention, early detection, diagnosis and treatment of cancer. - Coordinator: France (Gerard Brugal, gerard. brugal@imag.fr; URL: http://pathconsult.imag.fr/G7/G7_index.html) 3. Improving prevention, diagnosis and treatment of major cardiovascular diseases. - Coordinator: Italy (Attilio Maseri, amaseri@rm.unicatt.it; URL: http://www.g7cardio.org) 4. International concerted action for collaboration in telemedicine. - Coordinator: Canada (Andre Lacroix, lacroixa@ere.umontreal.ca; URL: http:// www.g7sp4.org) 5. Enabling mechanisms for a global healthcare network, including Internet connectivity. - Coordinator: UK (Ray Rogers, r.rogers@mcmail.com; URL: http://www.ehto.be/sp5) 6. International harmonisation of the use of data cards in healthcare: Internet Connectivity Coordinator: USA (Elliot R. Siegel, siegel@nlm.nih.gov; URL: http://www.nlm.nih.gov/) - Smart Cards and information exchange security in health care Joint Coordinators: France, European Commission, Italy and Germany (Jacques Sauret, jacques.sauret@sante.gouv.fr and G8-HC@sesam-vitale.fr; URL: http:/www.sesam-vitale.fr/Projects/Netlink-G7-En/) 7. Evidence and effectiveness. - Coordinator: Canada (Andrew Penn, andrew. penn@ualberta.ca; URL: http://www.medlib.com/spi/web.htm) 8. Multilingual anatomical digital database. - Coordinator: USA (Michael J. Ackermann; URL: http://www.nlm.nih.gov) 9. Medical image reference centre. - Coordinator: Japan (Eturo Kashiwagi

  19. Study on adsorption properties of QCS/PS-G8-2-8 anion exchange membrane for Rhodamine B

    NASA Astrophysics Data System (ADS)

    Zhang, Yang; Wang, Jilin; Wang, Lulu; Feng, Ruijiang; Zhang, Fan

    2015-06-01

    A series of novel anion exchange composite membrane (QCS/PS-G8-2-8) were synthesized based on the quaternized chitosan (QCS, DQ = 89.20 (±3.50)%) blended with block polymer of polystyrene (PS) and G8-2-8 (maleic acid diethyl brace base pairs [octyl dimethyl chloride/ammonium bromide]). Then the QCS was cross-linked by glutaraldehyde (GA). The parameters including adsorption time (t), pH, and initial concentration of Rhodamine B (C0), temperature (T), the mass fraction of G8-2-8 and GA (WGA) on the adsorption were investigated to determine the optimum condition for the removal of RB. The kinetic and thermodynamic properties of the adsorption process were also discussed. The optimum adsorption condition was that the adsorption time was 100 min, pH was 4, the initial concentration of RB was 100 mg L-1, the mass fraction of G8-2-8 was 5.0 wt%, the mass fraction of GA was 2.0 wt%, the temperature was 40 °C. Thus, RB optimum adsorption capacity (q) of the composite membrane QCS/PS-G8-2-8 (5.0%) (G8-2-8 mass content (wt.%) was 5.0%) was 17.04 mg g-1. The adsorption isotherm of the RB on the composite membrane can be well fitted with the Temkin equation. The adsorption kinetics can be well described by the pseudo-second-order kinetics model. The values of ΔG, ΔH and ΔS indicated that the adsorption of RB onto QCS/PS-G8-2-8 was spontaneous and exothermic.

  20. Cotton and Sustainability: Impacting Student Learning through Sustainable Cotton Summit

    ERIC Educational Resources Information Center

    Ha-Brookshire, Jung; Norum, Pamela

    2011-01-01

    Purpose: The purpose of this paper is to examine the effect of intensive extra-curricular learning opportunities on students' knowledge, skills, and attitudes regarding cotton and sustainability. Design/methodology/approach: A three-phase extra-curricular learning opportunity was designed to include a Sustainable Cotton Summit; pre-summit and…

  1. UNESCO and the World Summit on the Information Society.

    ERIC Educational Resources Information Center

    Abid, Abdelaziz

    The World Summit on the Information Society will be held in two phases: Geneva, December 10-12, 2003 and Tunis in 2005. The Summit began as an initiative of the 1998 ITU Plenipotentiary Conference when it was recognized that the gap between information "haves" and "have nots" was increasing while at the same time…

  2. Wild Food Summit: Anishinaabe Relearning Traditional Gathering Practices

    ERIC Educational Resources Information Center

    Sorensen, Barbara Ellen

    2011-01-01

    Wild Food Summits is a program initiated by Steve Dahlberg, the White Earth Tribal & Community College Extension director. Dahlberg began Wild Food Summits to teach people about identifying and gathering wild greens, mushrooms, and other edible plant life. The whole community comes together to cook and eat the foods. The tribal college has…

  3. Cotton and Sustainability: Impacting Student Learning through Sustainable Cotton Summit

    ERIC Educational Resources Information Center

    Ha-Brookshire, Jung; Norum, Pamela

    2011-01-01

    Purpose: The purpose of this paper is to examine the effect of intensive extra-curricular learning opportunities on students' knowledge, skills, and attitudes regarding cotton and sustainability. Design/methodology/approach: A three-phase extra-curricular learning opportunity was designed to include a Sustainable Cotton Summit; pre-summit and…

  4. Getting the Most Out of Your Summit: Planning Guide

    ERIC Educational Resources Information Center

    Forum for Youth Investment, 2008

    2008-01-01

    The America's Promise Alliance is supporting 50 state and at least 50 city Dropout Prevention Summits to be held by 2010. The purposes of the Dropout Prevention Summits are many, but the primary intention is to increase public awareness of the dropout and college-readiness crisis. The Forum for Youth Investment, America's Promise Alliance, United…

  5. Wild Food Summit: Anishinaabe Relearning Traditional Gathering Practices

    ERIC Educational Resources Information Center

    Sorensen, Barbara Ellen

    2011-01-01

    Wild Food Summits is a program initiated by Steve Dahlberg, the White Earth Tribal & Community College Extension director. Dahlberg began Wild Food Summits to teach people about identifying and gathering wild greens, mushrooms, and other edible plant life. The whole community comes together to cook and eat the foods. The tribal college has…

  6. 2016 Personalized Learning & Student Success Summit: Summary from the NMC

    ERIC Educational Resources Information Center

    New Media Consortium, 2016

    2016-01-01

    The New Media Consortium (NMC) hosted the Personalized Learning & Student Success Summit at SXSWedu on March 7-9 in Austin, Texas. The summit convened grantees and partners of the Postsecondary Strategy at the Bill & Melinda Gates Foundation and served as a call-to-action for education leaders to first imagine if and then commit to trying…

  7. 76 FR 52670 - 2011 Technology Transfer Summit North America Conference

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-23

    ... the TTS Initiative Business Social Network, an online business- networking platform powered by JuJaMa... in Bethesda, MD will be the site for the 2011 Tech Transfer Summit North America (TTSNA), the leading... Summit will strive to induce interactive debate, deliberation and discussion, networking and...

  8. 75 FR 11565 - Sunshine Act Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-11

    ... DISABILITY Sunshine Act Meetings Type: Quarterly Meeting. Dates and Times: April 19, 2010, 8:30 a.m.-3 p.m... Sessions; Emergency Management; Developmental Disabilities and Bill of Rights Act, International Development, National Summit on Disability Policy 2010, United States Marine Corps Research Project...

  9. 78 FR 51266 - Sunshine Act Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-20

    ... From the Federal Register Online via the Government Publishing Office TENNESSEE VALLEY AUTHORITY Sunshine Act Meetings The TVA Board of Directors will hold a public meeting on August 22, 2013, in the TVA West Tower Auditorium, 400 West Summit Hill Drive, Knoxville, Tennessee. Members of the public...

  10. Evaluation of AMGEN clone 9G8A anti-Epo antibody for application in doping control.

    PubMed

    Reichel, Christian; Benetka, Wolfgang; Lorenc, Barbara; Thevis, Mario

    2016-11-01

    The two mouse monoclonal anti-erythropoietin (EPO) antibodies clone AE7A5 (generated by using a 26 amino acid N-terminal EPO-peptide) and 9G8A (developed by immunizing mice with full length human EPO) are both directed against linear epitopes at the N-terminus of EPO. While AE7A5 has been commercially available for many years, 9G8A was made for Amgen's internal research purposes. In the past, the commercial antibody was shown to cross-react with several proteins unrelated to EPO (e.g. E. coli thioredoxin reductase, zinc-α2-glycoprotein, S. cerevisiae enolase, human neuron-specific enolase, and human non-neuronal enolase). However, it displayed high sensitivity for detecting recombinant EPO (rEPO) misuse by athletes on Western blots. We evaluated the potential use of clone 9G8A for doping control purposes. While 9G8A showed lower sensitivity than AE7A5 (ca 45% on isoelectric focusing (IEF)-polyacrylamide gel electrophoresis (PAGE), ca 40% on sodium dodecyl sulfate (SDS)- and sarcosyl (SAR)-PAGE), non-specific binding of the five proteins was not observed. The cross-reactivity of AE7A5 can be overcome by immunoaffinity purification of EPO before electrophoresis and Western blotting. Similar to AE7A5, clone 9G8A is also suited for Western double-blotting. Copyright © 2016 John Wiley & Sons, Ltd.

  11. The Education Summit; A Different Signal

    NASA Astrophysics Data System (ADS)

    Lagowski, J. J.

    1996-05-01

    The last National Education Summit held by the Governors occurred in Charlottesville, Virginia in 1989. That Summit, chaired by then Governor Clinton, produced the national goals for education announced by President Bush. These top-down goals are unfulfilled and are, for all practical purposes, dead. The 1996 Education Summit seems different, although its recommendations may suffer the same fate of those of the 1989 Summit. The 1996 Education Summit was held at IBM's Executive Conference Center in Palisades, New York. The Governors invited 44 executives of major businesses from virtually every state. CEO's from IBM, AT&T, Bell South, Eastman Kodak, Procter & Gamble, and Boeing were a part of the planning committee. Absent, for the most part, were professional educators and their organizations. The constitution of the 1996 Education Summit sent a clear signal, viz., that the "professional educators," whatever their individual talents, as a group have failed the nation's public schools and now its time for someone else to try. The "someone else" is the group of individuals that are the ultimate consumers of the output of the American education system. The collective point of view of the attending CEO's is that companies have undergone radical changes to become globally competitive, now it's time to keep the work force equally competitive. And this can only come through radical changes in the educational system. The CEO's point out that the companies they represent live or die by the (international) standards they establish, some of which are expressed in the principles of Total Quality Management (TQM), which represents a systemic approach to the changes American industry had to undergo to stay competitive. The executives clearly have run out of patience with the current system of public education. Many feel that they are running out of talented people to fill the important jobs that this society will need to fill to keep it moving forward. That talent is not being

  12. "we cannot Wait to ACT!" Simulating Global Climate Summits with Gifted and Talented Students

    NASA Astrophysics Data System (ADS)

    Haste, T.; Vesperman, D.; Alrivy, S.

    2012-12-01

    Students simulated the 2011 Durban Climate Summit in order to experience two roles: global diplomats attempting to solve a significant global problem and scientists as contributors of knowledge. Together, they worked to develop a framework to provide global solutions as world leaders. This project demonstrated [highlighted?] student work from the climate summit, describing how students promoted dialogue and provided climate science information to their diplomatic peers, who then used this information in diplomatic negotiations. By focusing on increasing student climate literacy, students engaged in both climate science and global diplomacy through meaningful simulations to understand the global and political issues surrounding Climate Change mitigation. Three classes of international middle school students attending Johns Hopkins Center for Talented Youth summer programs enacted the 2011 Durban Model United Nations meeting. One class developed a deep understanding of climate and climate science by working with computer models and data to represent members of the IPCC. Members of this class collaborated with climate scientists, conducted experiments, and developed a well-rounded understanding of paleoclimate, current climatic trends, carbon cycling, and modeling future outcomes. Two additional classes took on the roles of UN diplomats, researched their respective nations, engaged in practice UN simulations, and developed a working understanding of the diplomatic process. Students representing the IPCC assisted their diplomatic peers in developing and proposing possible UN resolutions. All three classes worked together to enact the Durban Climate Summit with the underlying focus of developing diplomatic Climate Change mitigation strategies and ultimately resolutions for member nations.

  13. 2004 ASM Conference on the New Phage Biology: the 'Phage Summit'.

    PubMed

    Adhya, Sankar; Black, Lindsay; Friedman, David; Hatfull, Graham; Kreuzer, Kenneth; Merril, Carl; Oppenheim, Amos; Rohwer, Forest; Young, Ry

    2005-03-01

    In August, more than 350 conferees from 24 countries attended the ASM Conference on the New Phage Biology, in Key Biscayne, Florida. This meeting, also called the Phage Summit, was the first major international gathering in decades devoted exclusively to phage biology. What emerged from the 5 days of the Summit was a clear perspective on the explosive resurgence of interest in all aspects of bacteriophage biology. The classic phage systems like lambda and T4, reinvigorated by structural biology, bioinformatics and new molecular and cell biology tools, remain model systems of unequalled power and facility for studying fundamental biological issues. In addition, the New Phage Biology is also populated by basic and applied scientists focused on ecology, evolution, nanotechnology, bacterial pathogenesis and phage-based immunologics, therapeutics and diagnostics, resulting in a heightened interest in bacteriophages per se, rather than as a model system. Besides constituting another landmark in the long history of a field begun by d'Herelle and Twort during the early 20th century, the Summit provided a unique venue for establishment of new interactive networks for collaborative efforts between scientists of many different backgrounds, interests and expertise.

  14. Emergency department operations dictionary: results of the second performance measures and benchmarking summit.

    PubMed

    Welch, Shari J; Stone-Griffith, Suzanne; Asplin, Brent; Davidson, Steven J; Augustine, James; Schuur, Jeremiah D

    2011-05-01

    The public, payers, hospitals, and Centers for Medicare and Medicaid Services (CMS) are demanding that emergency departments (EDs) measure and improve performance, but this cannot be done unless we define the terms used in ED operations. On February 24, 2010, 32 stakeholders from 13 professional organizations met in Salt Lake City, Utah, to standardize ED operations metrics and definitions, which are presented in this consensus paper. Emergency medicine (EM) experts attending the Second Performance Measures and Benchmarking Summit reviewed, expanded, and updated key definitions for ED operations. Prior to the meeting, participants were provided with the definitions created at the first summit in 2006 and relevant documents from other organizations and asked to identify gaps and limitations in the original work. Those responses were used to devise a plan to revise and update the definitions. At the summit, attendees discussed and debated key terminology, and workgroups were created to draft a more comprehensive document. These results have been crafted into two reference documents, one for metrics and the operations dictionary presented here. The ED Operations Dictionary defines ED spaces, processes, patient populations, and new ED roles. Common definitions of key terms will improve the ability to compare ED operations research and practice and provide a common language for frontline practitioners, managers, and researchers.

  15. Managing haemophilia for life: 4th Haemophilia Global Summit.

    PubMed

    Astermark, J; Dolan, G; Hilberg, T; Jiménez-Yuste, V; Laffan, M; Lassila, R; Lobet, S; Martinoli, C; Perno, C-F

    2014-07-01

    The 4th Haemophilia Global Summit was held in Potsdam, Germany, in September 2013 and brought together an international faculty of haemophilia experts and delegates from multidisciplinary backgrounds. The programme was designed by an independent Scientific Steering Committee of haemophilia experts and explored global perspectives in haemophilia care, discussing practical approaches to the optimal management of haemophilia now and in the future. The topics outlined in this supplement were selected by the Scientific Steering Committee for their relevance and potential to influence haemophilia care globally. In this supplement from the meeting, Jan Astermark reviews current understanding of risk factors for the development of inhibitory antibodies and discusses whether this risk can be modulated and minimized. Factors key to the improvement of joint health in people with haemophilia are explored, with Carlo Martinoli and Víctor Jiménez-Yuste discussing the utility of ultrasound for the early detection of haemophilic arthropathy. Other aspects of care necessary for the prevention and management of joint disease in people with haemophilia are outlined by Thomas Hilberg and Sébastian Lobet, who highlight the therapeutic benefits of physiotherapy and sports therapy. Riitta Lassila and Carlo-Federico Perno describe current knowledge surrounding the risk of transmission of infectious agents via clotting factor concentrates. Finally, different types of extended half-life technology are evaluated by Mike Laffan, with a focus on the practicalities and challenges associated with these products.

  16. Summary Points and Consensus Recommendations From the International Protein Summit.

    PubMed

    Hurt, Ryan T; McClave, Stephen A; Martindale, Robert G; Ochoa Gautier, Juan B; Coss-Bu, Jorge A; Dickerson, Roland N; Heyland, Daren K; Hoffer, L John; Moore, Frederick A; Morris, Claudia R; Paddon-Jones, Douglas; Patel, Jayshil J; Phillips, Stuart M; Rugeles, Saúl J; Sarav Md, Menaka; Weijs, Peter J M; Wernerman, Jan; Hamilton-Reeves, Jill; McClain, Craig J; Taylor, Beth

    2017-04-01

    The International Protein Summit in 2016 brought experts in clinical nutrition and protein metabolism together from around the globe to determine the impact of high-dose protein administration on clinical outcomes and address barriers to its delivery in the critically ill patient. It has been suggested that high doses of protein in the range of 1.2-2.5 g/kg/d may be required in the setting of the intensive care unit (ICU) to optimize nutrition therapy and reduce mortality. While incapable of blunting the catabolic response, protein doses in this range may be needed to best stimulate new protein synthesis and preserve muscle mass. Quality of protein (determined by source, content and ratio of amino acids, and digestibility) affects nutrient sensing pathways such as the mammalian target of rapamycin. Achieving protein goals the first week following admission to the ICU should take precedence over meeting energy goals. High-protein hypocaloric (providing 80%-90% of caloric requirements) feeding may evolve as the best strategy during the initial phase of critical illness to avoid overfeeding, improve insulin sensitivity, and maintain body protein homeostasis, especially in the patient at high nutrition risk. This article provides a set of recommendations based on assessment of the current literature to guide healthcare professionals in clinical practice at this time, as well as a list of potential topics to guide investigators for purposes of research in the future.

  17. Tackling tuberculosis: Insights from an international TB Summit in London

    PubMed Central

    Maitra, Arundhati; Danquah, Cynthia A; Scotti, Francesca; Howard, Tracey K; Kamil, Tengku K; Bhakta, Sanjib

    2015-01-01

    Tuberculosis (TB) poses a grave predicament to the world as it is not merely a scientific challenge but a socio-economic burden as well. A prime cause of mortality in human due to an infectious disease; the malady and its cause, Mycobacterium tuberculosis have remained an enigma with many questions that remain unanswered. The ability of the pathogen to survive and switch between varied physiological states necessitates a protracted therapeutic regimen that exerts an excessive strain on low-resource countries. To complicate things further, there has been a significant rise of antimicrobial resistance. Existing control measures, including treatment regimens have remained fairly uniform globally for at least half a century and require reinvention. Overcoming the societal and scientific challenges requires an increase in dialog to identify key regions that need attention and effective partners with whom successful collaborations can be fostered. In this report, we explore the discussions held at the International TB Summit 2015 hosted by EuroSciCon, which served as an excellent platform for researchers to share their recent findings. Ground-breaking results require outreach to affect policy design, governance and control of the disease. Hence, we feel it is important that meetings such as these reach a wider, global audience. PMID:26151309

  18. Report from the 2nd Cardiovascular Outcome Trial (CVOT) Summit of the Diabetes and Cardiovascular Disease (D&CVD) EASD Study Group.

    PubMed

    Schnell, Oliver; Standl, Eberhard; Catrinoiu, Doina; Genovese, Stefano; Lalic, Nebojsa; Skra, Jan; Valensi, Paul; Rahelic, Dario; Ceriello, Antonio

    2017-03-11

    The 2nd Cardiovascular Outcome Trial (CVOT) Summit of the Diabetes and Cardiovascular Disease (D&CVD) EASD Study Group was held on the 20th-21st October 2016 in Munich. This second Summit was organized in light of recently published CVOTs on diabetes, with the aim of serving as a reference meeting for discussion on this topic. Along with presentations on the results of the most recently published CVOTs, panel discussions on trial implications for reimbursement and the perspective of cardiologists and/or nephrologists, as well as on CVOTs weaknesses and potentials constituted the heart of the program. Future activities of the D&CVD EASD Study Group in 2017 include an annual meeting in Milano and the 3rd CVOT Summit on Diabetes of the D&CVD EASD Study Group, in Munich ( http://www.dcvd.org ).

  19. Athletic Training and Public Health Summit

    PubMed Central

    Hoffman, Mark; Bovbjerg, Viktor; Hannigan, Kim; Hootman, Jennifer M.; Johnson, Sam T.; Kucera, Kristen L.; Norcross, Marc F.

    2016-01-01

    Objective:  To introduce athletic trainers to the benefits of using a population-based approach to injury and illness prevention and to explore opportunities for partnering with public health professionals on these initiatives. Background:  Athletic trainers play leading roles in individual injury and illness prevention but are less familiar with policy development, evaluation, and implementation from a population-level standpoint. The Athletic Training and Public Health Summit was convened to understand, explore, and develop the intersection of athletic training and public health. Conclusions:  To further the integration of athletic training within the public health arena, athletic trainers must expand their professional focus beyond the individual to the population level. PMID:27295487

  20. Descent from the Summit of 'Husband Hill'

    NASA Technical Reports Server (NTRS)

    2005-01-01

    [figure removed for brevity, see original site] Click on the image for Descent from the Summit of 'Husband Hill' (QTVR)

    In late November 2005 while descending 'Husband Hill,' NASA's Mars Exploration Rover Spirit took the most detailed panorama so far of the 'Inner Basin,' the rover's next target destination. Spirit acquired the 405 individual images that make up this 360-degree view of the surrounding terrain using five different filters on the panoramic camera. The rover took the images on Martian days, or sols, 672 to 677 (Nov. 23 to 28, 2005 -- the Thanksgiving holiday weekend).

    This image is an approximately true-color rendering using camera's 750-, 530-, and 430-nanometer filters. Seams between individual frames have been eliminated from the sky portion of the mosaic to better simulate the vista a person standing on Mars would see.

    'Home Plate,' a bright, semi-circular feature scientists hope to investigate, is harder to discern in this image than in earlier views taken from higher up the hill. Spirit acquired this more oblique view, known as the 'Seminole panorama,' from about halfway down the south flank of Husband Hill, 50 meters (164 feet) or so below the summit. Near the center of the panorama, on the horizon, are 'McCool Hill' and 'Ramon Hill,' named, like Husband Hill, in honor of the fallen astronauts of the space shuttle Columbia. Husband Hill is visible behind the rover, on the right and left sides of the panorama. An arc of rover tracks made while avoiding obstacles and getting into position to examine rock outcrops can be traced over a long distance by zooming in to explore the panorama in greater detail.

    Spirit is now significantly farther downhill toward the center of this panorama, en route to Home Plate and other enigmatic soils and outcrop rocks in the quest to uncover the history of Gusev Crater and the 'Columbia Hills.'

  1. Descent from the Summit of 'Husband Hill'

    NASA Technical Reports Server (NTRS)

    2005-01-01

    [figure removed for brevity, see original site] Click on the image for Descent from the Summit of 'Husband Hill' (QTVR)

    In late November 2005 while descending 'Husband Hill,' NASA's Mars Exploration Rover Spirit took the most detailed panorama so far of the 'Inner Basin,' the rover's next target destination. Spirit acquired the 405 individual images that make up this 360-degree view of the surrounding terrain using five different filters on the panoramic camera. The rover took the images on Martian days, or sols, 672 to 677 (Nov. 23 to 28, 2005 -- the Thanksgiving holiday weekend).

    This image is an approximately true-color rendering using camera's 750-, 530-, and 430-nanometer filters. Seams between individual frames have been eliminated from the sky portion of the mosaic to better simulate the vista a person standing on Mars would see.

    'Home Plate,' a bright, semi-circular feature scientists hope to investigate, is harder to discern in this image than in earlier views taken from higher up the hill. Spirit acquired this more oblique view, known as the 'Seminole panorama,' from about halfway down the south flank of Husband Hill, 50 meters (164 feet) or so below the summit. Near the center of the panorama, on the horizon, are 'McCool Hill' and 'Ramon Hill,' named, like Husband Hill, in honor of the fallen astronauts of the space shuttle Columbia. Husband Hill is visible behind the rover, on the right and left sides of the panorama. An arc of rover tracks made while avoiding obstacles and getting into position to examine rock outcrops can be traced over a long distance by zooming in to explore the panorama in greater detail.

    Spirit is now significantly farther downhill toward the center of this panorama, en route to Home Plate and other enigmatic soils and outcrop rocks in the quest to uncover the history of Gusev Crater and the 'Columbia Hills.'

  2. Medical preparedness against chemical and biological incidents for the NATO Summit in Istanbul and lessons learned.

    PubMed

    Kenar, Levent; Karayilanoglu, Turan

    2006-01-01

    During the 2004 North Atlantic Treaty Organization (NATO) Summit, essential counter-measures, including medical preparedness, were taken to cope with any suspected terrorist case or events including the use of chemical or biological (CB) weapons. The Summit was held in Istanbul, a city that bridges two continents, and involved the participation of many Heads of State, Prime Ministers, and Defense Ministers from 26 NATO countries. First responders, including medical Chemical, Biological, Radiological, and Nuclear (CBRN) teams, received special training. Essential equipment, including drugs, antidotes, detectors, etc., was provided and stock-piled. Medical authorities augmented the capacity for identifying and controlling the injuries and any emerging CB incident through the set-up of decontamination units and the procurement of medical devices, antidotes, drugs, and personal protective suits. Additionally, a small part of the recently established NATO-CBRN battalion was welcomed to the Summit and was prepared to perform detection and identification of the agent found in suspicious appearing samples. Although no CB incident was reported during the Summit, extensive experience was gained with respect to medical preparedness against CB terrorism. Sampling, detection, and analysis of toxic materials were taken into account in the medical management. Much laboratory-related work was conducted in the following time period. The laboratory work involved the standardization of sampling and transportation procedures, development of both mobile and reference laboratories, and performing research activities aimed to make the CB analysis more efficient. Although the training of the medical staff was advanced, training should be continuous and supported with educational programs, conferences, meetings, and tabletop and hospital medical exercises throughout the country. Multidisciplinary cooperation, training, and preparedness should be provided to basic medical care units and

  3. The G8 Heart Health Projects Database: testing the compatibility of an Internet-based resource with health promotion planning processes.

    PubMed

    Hanusaik, Nancy; O'Loughlin, Jennifer; Ryan, Ann; Edwards, Alison C; West, Roy; Harvey, Dexter; Cameron, Roy

    2003-10-01

    This study examined the context and processes in which health promotion policy and program decisions are made to ensure that an Internet-based information system on heart health promotion programs provides appropriate information for decision makers' needs and is compatible with their decision-making processes. Five focus groups and six individual interviews were conducted with potential users of and contributors to the G8 Heart Health Projects Database. Results suggest that Internet-based systems such as this are seen as useful tools, but will only be used at certain critical points in program development and then, only when they meet several rigorous criteria. Systems must be completely credible and up-to-date, providing instant answers to complex questions about program design, implementation, and effectiveness, with adequate qualitative information for assessing contextual applicability. Participants also provided information about the conditions required if they were to submit project information to the system.

  4. What is causing high ozone at Summit, Greenland?

    NASA Astrophysics Data System (ADS)

    Helmig, Detlev; Oltmans, Samuel J.; Morse, Thomas O.; Dibb, Jack E.

    Causes for the unusually high and seasonally anomalous ozone concentrations at Summit, Greenland were investigated. Surface data from continuous monitoring, ozone sonde data, tethered balloon vertical profiling data, correlation of ozone with the radionuclide tracers 7Be and 210Pb, and synoptic transport analysis were used to identify processes that contribute to sources and sinks of ozone at Summit. Northern Hemisphere (NH) lower free troposphere ozone mixing ratios in the polar regions are ˜20 ppbv higher than in Antarctica. Ozone at Summit, which is at 3212 m above sea level, reflects its altitude location in the lower free troposphere. Transport events that bring high ozone and dry air, likely from lower stratospheric/higher tropospheric origin, were observed ˜40% of time during June 2000. Comparison of ozone enhancements with radionuclide tracer records shows a year-round correlation of ozone with the stratospheric tracer 7Be. Summit lacks the episodic, sunrise ozone depletion events, which were found to reduce the annual, median ozone at NH coastal sites by up to ˜3 ppbv. Synoptic trajectory analyses indicated that, under selected conditions, Summit encounters polluted continental air with increased ozone from central and western Europe. Low ozone surface deposition fluxes over long distances upwind of Summit reduce ozone deposition losses in comparison to other NH sites, particularly during the summer months. Surface-layer photochemical ozone production does not appear to have a noticeable influence on Summit's ozone levels.

  5. 2012 ARPA-E Energy Innovation Summit Keynote Presentation (Arun Majumdar)

    SciTech Connect

    Majumdar, Arun

    2012-02-28

    The third annual ARPA-E Energy Innovation Summit was held in Washington D.C. in February, 2012. The event brought together key players from across the energy ecosystem - researchers, entrepreneurs, investors, corporate executives, and government officials - to share ideas for developing and deploying the next generation of energy technologies. Director of ARPA-E, Arun Majumdar, gave the final keynote address for Tuesday, February 28th. He discussed APRA-E's role in meeting 21st century energy needs with American innovation.

  6. 2012 ARPA-E Energy Innovation Summit Keynote Presentation (Arun Majumdar)

    ScienceCinema

    Majumdar, Arun (ARPA-E Director)

    2016-07-12

    The third annual ARPA-E Energy Innovation Summit was held in Washington D.C. in February, 2012. The event brought together key players from across the energy ecosystem - researchers, entrepreneurs, investors, corporate executives, and government officials - to share ideas for developing and deploying the next generation of energy technologies. Director of ARPA-E, Arun Majumdar, gave the final keynote address for Tuesday, February 28th. He discussed APRA-E's role in meeting 21st century energy needs with American innovation.

  7. Summit Lake landslide and geomorphic history of Summit Lake basin, northwestern Nevada

    USGS Publications Warehouse

    Curry, B. Brandon; Melhorn, W.N.

    1990-01-01

    The Summit Lake landslide, northwestern Nevada, composed of Early Miocene pyroclastic debris, Ashdown Tuff, and basalt and rhyolite of the Black Rock Range, blocked the upper Soldier Creek-Snow Creek drainage and impounded Summit Lake sometimes prior to 7840 yr B.P. The slide covers 8.2 km2 and has geomorphic features characteristic of long run-out landslides, such as lobate form, longitudinal and transverse ridges, low surface gradient (7.1 ??), and preservation of original stratigraphic position of transported blocks. However, estimated debris volume is the smallest reported (2.5 ?? 105 m3) for a landslide of this type. The outflow channel of the Summit Lake basin was a northward-flowing stream valley entrenched by Mahogany Creek. Subsequent negative tectonic adjustment of the basin by about 35 m, accompanied by concommitant progradation of a prominent alluvial fan deposited by Mahogany Creek, argues for a probable diversion of drainage from the Alvord basin southward into the Lahontan basin. The landslide occurred while the creek flowed southward, transferring about 147 km2 of watershed from the Lahontan basin back to the Alvord basin. Overflow northward occurred during high stands of Pluvial Lake Parman in the basin; otherwise, under drier climates, the Summit Lake basin has been closed. Within large depressions on the slide surface, the ca. 6800 yr old Mazama Bed and other sediments have buried a weakly developed soil. Disseminated humus in the soil yields an age of 7840 ?? 310 yr B.P. Absence of older tephra (such as St. Helens M) brackets the slide age between 7840 and 19,000 yr B.P. Projectile points found on the highest strandlines of Pluvial Lake Parman suggest a ca 8700 yr B.P. age by correlation with cultural artifacts and radiocarbon ages from nearby Last Supper Cave, Nevada. Organic matter accumulation in landslide soils suggests ages ranging from 9100 to 16,250 yr B.P. Estimation of the age of the slide from morphologic data for the isolated Summit

  8. Summit Lake landslide and geomorphic history of Summit Lake basin, northwestern Nevada

    NASA Astrophysics Data System (ADS)

    Curry, B. Brandon; Melhorn, Wilton N.

    1990-11-01

    The Summit Lake landslide, northwestern Nevada, composed of Early Miocene pyroclastic debris, Ashdown Tuff, and basalt and rhyolite of the Black Rock Range, blocked the upper Soldier Creek-Snow Creek drainage and impounded Summit Lake sometimes prior to 7840 yr B.P. The slide covers 8.2 km 2 and has geomorphic features characteristic of long run-out landslides, such as lobate form, longitudinal and transverse ridges, low surface gradient (7.1 °), and preservation of original stratigraphic position of transported blocks. However, estimated debris volume is the smallest reported (2.5 × 10 5 m 3) for a landslide of this type. The outflow channel of the Summit Lake basin was a northward-flowing stream valley entrenched by Mahogany Creek. Subsequent negative tectonic adjustment of the basin by about 35 m, accompanied by concommitant progradation of a prominent alluvial fan deposited by Mahogany Creek, argues for a probable diversion of drainage from the Alvord basin southward into the Lahontan basin. The landslide occurred while the creek flowed southward, transferring about 147 km 2 of watershed from the Lahontan basin back to the Alvord basin. Overflow northward occurred during high stands of Pluvial Lake Parman in the basin; otherwise, under drier climates, the Summit Lake basin has been closed. Within large depressions on the slide surface, the ca. 6800 yr old Mazama Bed and other sediments have buried a weakly developed soil. Disseminated humus in the soil yields an age of 7840 ± 310 yr B.P. Absence of older tephra (such as St. Helens M) brackets the slide age between 7840 and 19,000 yr B.P. Projectile points found on the highest strandlines of Pluvial Lake Parman suggest a ca 8700 yr B.P. age by correlation with cultural artifacts and radiocarbon ages from nearby Last Supper Cave, Nevada. Organic matter accumulation in landslide soils suggests ages ranging from 9100 to 16,250 yr B.P. Estimation of the age of the slide from morphologic data for the isolated

  9. Comparative Indicators of Education in the United States and Other G-8 Countries: 2009. NCES 2009-039

    ERIC Educational Resources Information Center

    Miller, David C.; Sen, Anindita; Malley, Lydia B.; Burns, Stephanie D.

    2009-01-01

    This report describes how the education system in the United States compares with education systems in the other Group of Eight (G-8) countries (Canada, France, Germany, Italy, Japan, the Russian Federation, the United Kingdom) that are among the world's most economically developed countries and among the United States' largest economic partners.…

  10. Comparative Indicators of Education in the United States and Other G-8 Countries: 2011. NCES 2012-007

    ERIC Educational Resources Information Center

    Miller, David C.; Warren, Laura K.

    2011-01-01

    This is the 2011 edition of a biennial series of compendia describing key education outcomes and contexts of education in the Group of Eight (G-8) countries--Canada, France, Germany, Italy, Japan, the Russian Federation, the United Kingdom, and the United States. The report is organized into five topical areas: population and school enrollment,…

  11. Comparative Indicators of Education in the United States and Other G8 Countries: 2004. NCES 2005-021

    ERIC Educational Resources Information Center

    Sen, Anindita; Partelow, Lisette A.; Miller, David C.

    2005-01-01

    This report is designed to describe how the U.S. education system compares with the education systems in the Group of Eight, or G8, countries. These countries, Canada, France, Germany, Italy, Japan, the Russian Federation, the United Kingdom, and the United States, are among the world's most economically developed. Comparative Indicators of…

  12. Comparative Indicators of Education in the United States and Other G-8 Countries: 2006. NCES 2007-006

    ERIC Educational Resources Information Center

    Miller, David C.; Sen, Anindita; Malley, Lydia B.

    2007-01-01

    This report describes how the education system in the United States compares with education systems in the other Group of Eight (G-8) countries: Canada, France, Germany, Italy, Japan, the Russian Federation and the United Kingdom. The report draws on the most current information about education from three primary sources: the Indicators of…

  13. COST Actions G1 and G8: EU programs on the use of radiation in art and archaeometry

    NASA Astrophysics Data System (ADS)

    Adriaens, Annemie; Demortier, Guy

    2004-11-01

    This paper gives an overview of the research activities within the European COST Actions G1 and G8. Both actions aim at achieving a better preservation and conservation of our cultural heritage by increasing the knowledge in art and archaeological objects through chemical and physical analyses.

  14. Winter Camp: A Blog from the Greenland Summit, Part II

    NASA Technical Reports Server (NTRS)

    Koenig, Lora

    2009-01-01

    An earlier issue presents the first half of the author's experience living and working at the National Science Foundation's (NSF) Greenland Summit Camp. The author is a remote-sensing glaciologist at NASA s Goddard Space Flight Center. She took measurements that will be used to validate data collected by NASA s Aqua, Terra, and Ice, Clouds, and land Elevation Satellite (ICESat) satellites with ground-truth measurements of the Greenland Ice Sheet she made at Summit Camp from November 2008-February 2009. This article presents excerpts from the second half of her stay and work at the Greenland Summit.

  15. Potable Water Supply Feasibility Study for Summit Station, Greenland

    DTIC Science & Technology

    2011-03-01

    ER D C/ CR R EL T R -1 1 -4 Potable Water Supply Feasibility Study for Summit Station, Greenland C ol d R eg io n s R es ea rc h a n...Feasibility Study for Summit Station, Greenland Robert B. Haehnel and Margaret A. Knuth Cold Regions Research and Engineering Laboratory U.S. Army...that may be applicable for use at Summit Station, Greenland . The two methods that are most widely used at polar field sites are melting surface snow

  16. Antarctic Treaty Summit to Focus on Global Science Policy Lessons

    NASA Astrophysics Data System (ADS)

    Berkman, Paul Arthur; Walton, David W. H.; Weiler, C. Susan

    2008-10-01

    The Antarctic Treaty Summit, which will coincide with the fiftieth anniversary of the treaty's signing, will be held at the Smithsonian Institution's National Museum of Natural History, in Washington, D. C., from 30 November to 3 December 2009. The summit will provide an open international forum for scientists, legislators, lawyers, administrators, educators, students, corporate executives, historians, and other members of global civil society to explore science policy achievements from the first 50 years of the Antarctic Treaty. In addition, the summit will complement official government celebrations of the Antarctic Treaty anniversary that do not include public participation.

  17. Proceedings Report from the Sustainability Education Summit, September 20-21, 2010

    ERIC Educational Resources Information Center

    US Department of Education, 2011

    2011-01-01

    The first-ever U. S. Department of Education summit on sustainability, "Sustainability Education Summit: Citizenship and Pathways for a Green Economy," was held on Sept. 20-21, 2010, in Washington, D.C. The Sustainability Education Summit (the Summit) brought together leaders from higher education, business and industry, labor,…

  18. 2013 Summit on Reducing Exposure to Dust from Treated Seed

    EPA Pesticide Factsheets

    The Pollinator Summit was part of EPA's ongoing collaboration with stakeholders to manage pesticide risks to bees. Focus: how to protect bees from unintended pesticide exposure, esp. dust in agricultural planting operations using pesticide-coated seeds.

  19. 29. ROAD TO SUMMIT SHOWING VISITOR OVERLOOK AND SCIENCE CITY, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    29. ROAD TO SUMMIT SHOWING VISITOR OVERLOOK AND SCIENCE CITY, FROM ATOP WHITE HILL. NOTE THE ARCHAEOLOGICAL REMAINS OF WHAT APPEARS TO BE A CIRCULAR SHELTER AT LOWER RIGHT. - Haleakala National Park Roads, Pukalani, Maui County, HI

  20. 3. ROAD TO SUMMIT SHOWING VISITOR OVERLOOK AND SCIENCE CITY, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. ROAD TO SUMMIT SHOWING VISITOR OVERLOOK AND SCIENCE CITY, FROM ATOP WHITE HILL. NOTE THE ARCHAEOLOGICAL REMAINS OF WHAT APPEARS TO BE A CIRCULAR SHELTER AT LOWER RIGHT. - Haleakala National Park Roads, Pukalani, Maui County, HI

  1. U.S.-European Union Relations and the 2007 Summit

    DTIC Science & Technology

    2007-04-13

    2007 summit to launch initiatives jointly promoting technological advances in biofuels, energy efficiency, methane recovery, and clean coal and carbon ... capture and storage. Although European officials agree with the United States that these technologies should help to improve transatlantic energy

  2. Summit Equipment & Supplies, Inc. Five-Year Reviews

    EPA Pesticide Factsheets

    The Summit Equipment & Supplies site in Akron, OH is a former salvage yard and scrap metal facility with PCB contamination of soil on-site, off-site movement of the PCBs, and ground water contamination under the site.

  3. Don't wait for Paris summit to improve health.

    PubMed

    Soares, Andréia Azevedo; Figueres, Christiana

    2015-11-01

    How developing countries will make the transition to sustainable clean-energy economies is a major challenge for the United Nations summit that opens in Paris this month. Christiana Figueres talks to Andréia Azevedo Soares.

  4. Energy Department to Host First Sustainable Transportation Summit

    SciTech Connect

    Sarkar, Reuben

    2016-06-29

    On July 11-12, mobility and transportation leaders from across the country are coming to Washington, D.C. for the inaugural Sustainable Transportation Summit hosted by the Office of Energy Efficiency and Renewable Energy (EERE).

  5. President Barack Obama at UN Climate Change Summit

    SciTech Connect

    Obama, Barack

    2009-01-01

    In his first address to the United Nations as Commander-in- Chief, President Obama addresses the pressing issue of climate change. The one-day UN summit brought together delegations from 90 nations. September 22, 2009 (Public Domain)

  6. President Barack Obama at UN Climate Change Summit

    ScienceCinema

    Obama, Barack

    2016-07-12

    In his first address to the United Nations as Commander-in- Chief, President Obama addresses the pressing issue of climate change. The one-day UN summit brought together delegations from 90 nations. September 22, 2009 (Public Domain)

  7. Energy Department to Host First Sustainable Transportation Summit

    ScienceCinema

    Sarkar, Reuben

    2016-08-17

    On July 11-12, mobility and transportation leaders from across the country are coming to Washington, D.C. for the inaugural Sustainable Transportation Summit hosted by the Office of Energy Efficiency and Renewable Energy (EERE).

  8. Full-Genome Characterization of a G8P[8] Rotavirus That Emerged among Children with Diarrhea in Croatia in 2006

    PubMed Central

    Delogu, Roberto; Lo Presti, Alessandra; Cella, Eleonora; Giovanetti, Marta; Ciccozzi, Massimo; Ljubin-Sternak, Suncanica; Bukovski-Simonoski, Suzana; Lukic-Grlic, Amarela; Ianiro, Giovanni; Fiore, Lucia

    2013-01-01

    The whole genome of a G8P[8] rotavirus from the 2006 epidemic in Croatia was sequenced and showed a Wa-like genotype constellation. Its VP7 gene clustered with DS-1-like G8 African rotaviruses and a G8P[4] German strain. Remaining genes clustered with contemporary Belgian G1P[8] rotaviruses, suggesting reassortment between human G8 and G1P[8] rotaviruses in Croatia or other European countries. PMID:23426928

  9. Securing Nuclear Materials: The 2010 Summit and Issues for Congress

    DTIC Science & Technology

    2011-04-27

    rm/2009a/10/130806 htm. 7 Attendees included Algeria, Argentina, Armenia, Australia, Belgium, Brazil, Canada, Chile , China, the Czech Republic...example, just prior to the summit, Chile , with U.S. assistance, removed the remaining HEU at research facilities;14 Malaysia passed national export...14 “Ahead of Nuclear Summit, NNSA Announces Removal of All Highly Enriched Uranium from Chile ,” NNSA Press Release, April 8, 2010, http

  10. Drug discovery summit: 11(th) Swiss Course on Medicinal Chemistry.

    PubMed

    Frei, Priska; Navarra, Giulio; Sager, Christoph P; Silbermann, Marleen; Varga, Norbert; Wamhoff, Eike-Christian

    2015-03-01

    A summit amongst the summits: The 11(th) Swiss Course on Medicinal Chemistry was held in October 2014, again in the scenic setting of the Alps in Leysin, Switzerland. One hundred participants, mostly from industry, experienced a week of expert talks about numerous aspects of drug discovery and medicinal chemistry. In this conference report, we briefly summarize the essential topics of this event, while the most inspiring lectures are described in greater detail.

  11. Ice Column Design Concept for Summit Station: Laboratory Testing Results

    DTIC Science & Technology

    2013-06-01

    Sodhi, D.S. 2013. Personal communication Steffen, K., J. E. Box, and W. Abdalati. 1996. Greenland Climate Network: GC-Net. In Glaciers , Ice Sheets...slip form footer design concept at temperature conditions representing those at Summit Station, Greenland (–20°C [–4°F]). We explored its ability...sign Concept features new facilities for long term atmospheric studies at Summit Station, Greenland (Kumin Associates and CH2MHill 2010; Dibb et al

  12. The effects of ABCG5/G8 polymorphisms on HDL-cholesterol concentrations depend on ABCA1 genetic variants in the Boston Puerto Rican health study

    USDA-ARS?s Scientific Manuscript database

    Background and aims: ATP-binding cassette transporters G5/G8 (ABCG5/G8) are associated with HDL-C concentrations. To assess whether the effect of ABCG5/G8 genetic variants on HDL-C concentrations is dependent on ATP-binding cassette transporters A1 (ABCA1), we studied potential interactions between ...

  13. Antarctic Treaty Summit: Washington, DC (2009)

    NASA Astrophysics Data System (ADS)

    Berkman, P. A.; Young, O. R.

    2005-12-01

    Advancement in Earth system science and international cooperation have been intertwined with the International Polar Years since 1882. In particular, the 3rd International Polar Year (which was convened as the International Geophysical Year from 1 July 1957 through 31 December 1958) specifically demonstrates the role of science in international policy: Acknowledging the substantial contributions to scientific knowledge resulting from international cooperation in scientific investigation in Antarctica; Convinced that the establishment of a firm foundation for the continuation and development of such cooperation on the basis of freedom of scientific investigation in Antarctica as applied during the International Geophysical Year accords with the interests of science and the progress of all mankind; Preamble, 1959 Antarctic Treaty To commemorate the 50th anniversary of the 1959 Antarctic Treaty and to explore the complexities of the science-policy relationship through the lens of a well-constrained case study, an international and interdisciplinary Antarctic Treaty Summit is being planned for 2009 in Washington, DC in conjunction with the International Polar Year 2007-08 (http://www.ipy.org).

  14. Ligand migration in the truncated hemoglobin-II from Mycobacterium tuberculosis: the role of G8 tryptophan.

    PubMed

    Guallar, Victor; Lu, Changyuan; Borrelli, Kenneth; Egawa, Tsuyoshi; Yeh, Syun-Ru

    2009-01-30

    Resonance Raman studies show that the heme-bound CO in trHbO, a truncated-II hemoglobin from Mycobacterium tuberculosis, is exposed to an environment with a positive electrostatic potential. The mutation of Trp(G8), an absolutely conserved residue in group II and III truncated hemoglobins, to Phe introduces two new Fe-CO conformers, both of which exhibit reduced electrostatic potentials. Computer simulations reveal that the structural perturbation is a result of the increased flexibility of the Tyr(CD1) and Leu(E11) side chains due to the reduction of the size of the G8 residue. Laser flash photolysis studies show that the G8 mutation induces 1) the presence of two new geminate recombination phases, one with a rate faster than the time resolution of our instrument and the other with a rate 13-fold slower than that of the wild type protein, and 2) the reduction of the total geminate recombination yield from 86 to 62% and the increase in the bimolecular recombination rate by a factor of 530. Computer simulations uncover that the photodissociated ligand migrates between three distal temporary docking sites before it subsequently rebinds to the heme iron or ultimately escapes into the solvent via a hydrophobic tunnel. The calculated energy profiles associated with the ligand migration processes are in good agreement with the experimental observations. The results highlight the importance of the Trp(G8) in regulating ligand migration in trHbO, underscoring its pivotal role in the structural and functional properties of the group II and III truncated hemoglobins.

  15. SR proteins SRp20 and 9G8 contribute to efficient export of herpes simplex virus 1 mRNAs

    SciTech Connect

    Escudero-Paunetto, Laurimar; Li Ling; Hernandez, Felicia P.; Sandri-Goldin, Rozanne M.

    2010-06-05

    Herpes simplex virus 1 (HSV-1) mRNAs are exported to the cytoplasm through the export receptor TAP/NFX1. HSV-1 multifunctional protein ICP27 interacts with TAP/NXF1, binds viral RNAs, and is required for efficient viral RNA export. In ICP27 mutant infections, viral RNA export is reduced but not ablated, indicating that other export adaptors can aid in viral RNA export. Export adaptor protein Aly/REF is recruited to viral replication compartments, however, Aly/REF knockdown has little effect on viral RNA export. SR proteins SRp20 and 9G8 interact with TAP/NXF1 and mediate export of some cellular RNAs. We report that siRNA knockdown of SRp20 or 9G8 resulted in about a 10 fold decrease in virus yields and in nuclear accumulation of poly(A+) RNA. In infected cells depleted of SRp20, newly transcribed Bromouridine-labeled RNA also accumulated in the nucleus. We conclude that SRp20 and 9G8 contribute to HSV-1 RNA export.

  16. The Social Development Summit and the developing countries.

    PubMed

    Barnabas, A P; Kulkarni, P D; Nanavatty, M C; Singh, R R

    1996-01-01

    This article discusses some concerns of the 1996 UN Summit on Social Development. Conference organizers identified the three key conference issues as poverty alleviation, social integration of the marginalized and disadvantaged, and expansion of productive employment. The goal of a "society for all" means dealing with the increasing differences between rich and poor countries, the survival of weaker economies in a competitive market system, wide variations in consumption patterns between countries, attainment of political stability while respecting ethnic identity, the rise in social problems among countries with a high human development index, and increasing joblessness. The Human Development Report for 1994 emphasizes human security. Social development is not the equivalent of human resource development nor a side issue of economic growth. The integration of ethnic groups poses social and political problems. There remains a question about what political system and culture would be best for social integration. Developed countries define poverty as the inability of people and government to provide resources and necessary services for people's productive activity. Poverty in developing countries is blamed on colonialism. Globally, developed countries control 71% of world trade. Sharing resources to meet basic needs throughout the world is not an operational ideal. The highest 20% of income earners receive 83% of the world income. The culture of poverty is the strategy used by the poor to survive. Welfare is not an end in itself but does enable the poor to improve their conditions. Development that focuses on productive employment is uncertain. Developed and developing countries do not share similar perceptions of human rights. There is a question as to who should set the priorities for social development. Sustainable social development is related to preservation of natural resources, control of population growth, and promotion of social security.

  17. Olympus: The Ultimate Summit for Science

    NASA Technical Reports Server (NTRS)

    Kelly, Darrell; Holt, Stephen (Technical Monitor)

    2000-01-01

    High above the world-class observatories that dot Hawaii's dormant Mauna Kea volcano, floating farther yet over the hostile and nearly inaccessible peaks of Mt. Everest, lies a summit waiting to be conquered. Here above the clouds and city lights and over 99.7% of the atmosphere is a platform on the edge of space, home to a broad range of astronomy and physics experiments. Today, balloons are lifting experiments longer, higher and more inexpensively than ever before, and returning them safely to Earth for reuse. Week-long flights at altitudes of approximately 35 kilometers carrying payloads in excess of several tons are the norm. NASA now plans to extend this platform and create a new generation of balloons capable of staying afloat with such cargo for 100 days and ultimately 1,000 days. What do some scientists hope to accomplish with 100 or even 1,000 days at the edge of space? To name but a few proposals on the table: Jupiter-size planet searches, large-aperture solar astronomy, large-aperture infrared astronomy, cosmic-ray investigations, long-duration Earth science missions, and hard x-ray imaging experiments. Olympus defines a new era in scientific ballooning. Advances in material science and trajectory control are enabling revolutionary capabilities. Very large scientific payloads can now be reliably launched and retrieved for reflight at a range of altitudes. Balloon flight still remains a fraction of the cost of a rocket launch. The ultra long duration balloon, with its 100-day maiden flight planned for 2001, provides a long-term facility in a near-space environment for many types of science. This is a stratospheric mountaintop well worth the climb.

  18. Mushrooms and Health Summit Proceedings123

    PubMed Central

    Feeney, Mary Jo; Dwyer, Johanna; Hasler-Lewis, Clare M.; Milner, John A.; Noakes, Manny; Rowe, Sylvia; Wach, Mark; Beelman, Robert B.; Caldwell, Joe; Cantorna, Margherita T.; Castlebury, Lisa A.; Chang, Shu-Ting; Cheskin, Lawrence J.; Clemens, Roger; Drescher, Greg; Fulgoni, Victor L.; Haytowitz, David B.; Hubbard, Van S.; Law, David; Myrdal Miller, Amy; Minor, Bart; Percival, Susan S.; Riscuta, Gabriela; Schneeman, Barbara; Thornsbury, Suzanne; Toner, Cheryl D.; Woteki, Catherine E.; Wu, Dayong

    2014-01-01

    The Mushroom Council convened the Mushrooms and Health Summit in Washington, DC, on 9–10 September 2013. The proceedings are synthesized in this article. Although mushrooms have long been regarded as health-promoting foods, research specific to their role in a healthful diet and in health promotion has advanced in the past decade. The earliest mushroom cultivation was documented in China, which remains among the top global mushroom producers, along with the United States, Italy, The Netherlands, and Poland. Although considered a vegetable in dietary advice, mushrooms are fungi, set apart by vitamin B-12 in very low quantity but in the same form found in meat, ergosterol converted with UV light to vitamin D2, and conjugated linoleic acid. Mushrooms are a rare source of ergothioneine as well as selenium, fiber, and several other vitamins and minerals. Some preclinical and clinical studies suggest impacts of mushrooms on cognition, weight management, oral health, and cancer risk. Preliminary evidence suggests that mushrooms may support healthy immune and inflammatory responses through interaction with the gut microbiota, enhancing development of adaptive immunity, and improved immune cell functionality. In addition to imparting direct nutritional and health benefits, analysis of U.S. food intake survey data reveals that mushrooms are associated with higher dietary quality. Also, early sensory research suggests that mushrooms blended with meats and lower sodium dishes are well liked and may help to reduce intakes of red meat and salt without compromising taste. As research progresses on the specific health effects of mushrooms, there is a need for effective communication efforts to leverage mushrooms to improve overall dietary quality. PMID:24812070

  19. The 1992 Earth Summit: background and prospects.

    PubMed

    Strong, M F

    1992-03-01

    In 1989, the UN General Assembly agreed to sponsor a conference on environment and development and that the Heads of State would attend this 1st ever Earth Summit in June 1992. The planned agenda included making concrete changes to the basis of our economic life, relations between and among nations, and the outlook for the future. This would result in restructuring world priorities. Despite the 1972 Stockholm Conference on the human Environment acknowledging the basic link between environment and development, the environment has deteriorated even further, especially ozone depletion. Yet some governments did set up environmental agencies or ministries, like the US Environmental Protection Agency, but they were not allowed to influence economic policy or the policies and/or practices of major sectoral agencies. These environmental organizations relied too heavily on regulation. The 1992 conference needs to result in a political commitment to place reduction of poverty worldwide as the 1st priority since poverty and underdevelopment are strongly related to destruction of the environment. It is particularly important that developing countries improve their strengths by developing their human resources and institutional capacities (science, technology, management and professional skills) and reduce their vulnerabilities, such as dependence on foreign experts. This can best be achieved if they have access to technology. Moreover they must reduce population growth and reach population stability quickly. The 1992 conference in Brazil should also result in a global partnership based on common interest, mutual need, and shared responsibility. The world ecoindustrial revolution has already begun in some countries, such as Japan which has reduced energy use 40% since 1975. In fact, Japan has proven that environmental improvement can be accomplished with high rates of economic growth.

  20. Mt. Whitney: determinants of summit success and acute mountain sickness.

    PubMed

    Wagner, Dale R; D'Zatko, Kim; Tatsugawa, Kevin; Murray, Ken; Parker, Daryl; Streeper, Tim; Willard, Kevin

    2008-10-01

    The aim of this study was to determine the prevalence of summit success and acute mountain sickness (AMS) on Mt. Whitney (4419 m) and to identify variables that contribute to both. Hikers (N = 886) attempting the summit were interviewed at the trailhead upon their descent. Questionnaires included demographic and descriptive data, acclimatization and altitude history, and information specific to the ascent. The Lake Louise Self-Assessment Score was used to make a determination about the occurrence of AMS. Logistic regression techniques were used to calculate odds ratios (OR) for AMS and summit success. Forty-three percent of the sample met the criteria for AMS, and 81% reached the summit. The odds of experiencing AMS were reduced with increases in age (adjusted 10-yr OR = 0.78; P < 0.001), number of hours spent above 3000 m in the 2 wk preceding the ascent (adjusted 24-h OR = 0.71; P < 0.001), and for females (OR = 0.68; P = 0.02). Climbers who had a history of AMS (OR = 1.41; P = 0.02) and those taking analgesics (OR = 2.39; P < 0.001) were more likely to experience AMS. As climber age increased, the odds of reaching the summit decreased (adjusted 10-yr OR = 0.75; P < 0.001). However, increases in the number of hours per week spent training (adjusted 5-h OR = 1.24; P = 0.05), rate of ascent (adjusted 50 m x h(-1) OR = 1.13; P = 0.04), and previous high-altitude record (adjusted 500 m OR = 1.26; P < 0.001) were all associated with increased odds for summit success. A high percentage of trekkers reached the summit despite having symptoms of AMS.

  1. Developing the science of end-of-life and palliative care research: National Institute of Nursing Research summit.

    PubMed

    Csikai, Ellen L

    2011-01-01

    A rare opportunity to examine accomplishments and identify ways to advance research in end-of-life and palliative care was offered by the National Institute of Nursing Research (NINR) through a summit meeting held in August 2011. The Science of Compassion: Future Directions in End-of-Life and Palliative Care brought together nationally recognized leaders in end-of-life and palliative care research, including grantees of NINR, as well as more than 700 attendees from all disciplines. It was an exciting affirmation of the importance of moving forward in the field. Presented in this article is a summary of the summit and a call to action for end-of-life and palliative care social workers to engage in seeking funding to conduct needed research and to ensure our unique perspective is represented.

  2. Characterization of human rotaviruses circulating in Iraq in 2008: atypical G8 and high prevalence of P[6] strains.

    PubMed

    Ahmed, Salwa; Klena, John; Albana, Antun; Alhamdani, Faisal; Oskoff, John; Soliman, Mireille; Heylen, Elisabeth; Teleb, Nadia; Husain, Tupur; Matthijnssens, Jelle

    2013-06-01

    Fecal samples from 976 children with gastroenteritis were collected and analyzed for group A rotavirus (RVA), in three different cities in Iraq between January 2008 and December 2008. RVA antigen was detected in 394 (40%) of the samples, and 98 samples were available for further genotype analyses using multiplex RT-PCR and sequence analyses for untypeable strains. The G/P-genotype combination was determined for 69 samples, and 19, 2 and 8 samples remained P-untypeable, G-untypeable and G/P-untypeable (UT), respectively. The most prevalent genotype was G2 (40%, 39/98) most often associated with P[6]. G1 was the second most common genotype (16%, 16/98) mainly associated with P[8] and P[UT]. G3, G4 and G9 were detected at a lower prevalence (3%, 11%, 3%, respectively), mainly associated with P[6]. Surprisingly, five G8P[6], and seven G12 RVA strains in combination with P[6] and P[8] were also detected for the first time in Iraq. Overall, a striking high prevalence of 47% of the analyzed samples possessed the P[6] genotype (65% of the P-typed RVA strains). Atypical genotype combinations such as G1P[4], G1P[6], G2P[8] or strains with mixed G-types were detected sporadically. The detection of unusual G8P[6] RVA strains prompted us to further analyze the NSP2, NSP3, NSP4 and NSP5 gene segments of three selected G8P[6] strains, resulting in their designation to the N2, T2, E2 and H2 genotypes, respectively. The VP7, VP4, NSP2, NSP3 and NSP5 gene segments clustered closely with common human RVA strains, whereas the NSP4 gene sequences were found to cluster with animal derived RVA strains, suggesting a potential reassortment event. The high prevalence of RVA strains with the G8, G12 and P[6] genotypes in combination with a DS-1-like genotype constellation in Iraq, needs to be monitored closely as these RVA strains might challenge the effectiveness of current RVA vaccines.

  3. Emergency department performance measures updates: proceedings of the 2014 emergency department benchmarking alliance consensus summit.

    PubMed

    Wiler, Jennifer L; Welch, Shari; Pines, Jesse; Schuur, Jeremiah; Jouriles, Nick; Stone-Griffith, Suzanne

    2015-05-01

    The objective was to review and update key definitions and metrics for emergency department (ED) performance and operations. Forty-five emergency medicine leaders convened for the Third Performance Measures and Benchmarking Summit held in Las Vegas, February 21-22, 2014. Prior to arrival, attendees were assigned to workgroups to review, revise, and update the definitions and vocabulary being used to communicate about ED performance and operations. They were provided with the prior definitions of those consensus summits that were published in 2006 and 2010. Other published definitions from key stakeholders in emergency medicine and health care were also reviewed and circulated. At the summit, key terminology and metrics were discussed and debated. Workgroups communicated online, via teleconference, and finally in a face-to-face meeting to reach consensus regarding their recommendations. Recommendations were then posted and open to a 30-day comment period. Participants then reanalyzed the recommendations, and modifications were made based on consensus. A comprehensive dictionary of ED terminology related to ED performance and operation was developed. This article includes definitions of operating characteristics and internal and external factors relevant to the stratification and categorization of EDs. Time stamps, time intervals, and measures of utilization were defined. Definitions of processes and staffing measures are also presented. Definitions were harmonized with performance measures put forth by the Centers for Medicare and Medicaid Services (CMS) for consistency. Standardized definitions are necessary to improve the comparability of EDs nationally for operations research and practice. More importantly, clear precise definitions describing ED operations are needed for incentive-based pay-for-performance models like those developed by CMS. This document provides a common language for front-line practitioners, managers, health policymakers, and researchers.

  4. Summit on medical school education in sexual health: report of an expert consultation.

    PubMed

    Coleman, Eli; Elders, Joycelyn; Satcher, David; Shindel, Alan; Parish, Sharon; Kenagy, Gretchen; Bayer, Carey Roth; Knudson, Gail; Kingsberg, Sheryl; Clayton, Anita; Lunn, Mitchell R; Goldsmith, Elizabeth; Tsai, Perry; Light, Alexis

    2013-04-01

    INTRODUCTION.: Medical education in sexual health in the United States and Canada is lacking. Medical students and practicing physicians report being underprepared to adequately address their patients' sexual health needs. Recent studies have shown little instruction on sexual health in medical schools and little consensus around the type of material medical students should learn. To address and manage sexual health issues, medical students need improved education and training. AIM.: This meeting report aims to present findings from a summit on the current state of medical school education in sexual health and provides recommended strategies to better train physicians to address sexual health. METHODS.: To catalyze improvements in sexual health education in medical schools, the summit brought together key U.S. and Canadian medical school educators, sexual health educators, and other experts. Attendees reviewed and discussed relevant data and potential recommendations in plenary sessions and then developed key recommendations in smaller breakout groups. RESULTS.: Findings presented at the summit demonstrate that the United States and Canada have high rates of poor sexual health outcomes and that sexual health education in medical schools is variable and in some settings diminished. To address these issues, government, professional, and student organizations are working on efforts to promote sexual health. Several universities already have sexual health curricula in place. Evaluation mechanisms will be essential for developing and refining sexual health education. CONCLUSIONS.: To be effective, sexual health curricula need to be integrated longitudinally throughout medical training. Identifying faculty champions and supporting student efforts are strategies to increase sexual health education. Sexual health requires a multidisciplinary approach, and cross-sector interaction between various public and private entities can help facilitate change. Areas important to

  5. The first national adult immunization summit 2012: implementing change through action.

    PubMed

    Shen, Angela K; Bridges, Carolyn B; Tan, Litjen

    2013-01-02

    To address lagging vaccine coverage among adults in the United States, over 150 organizations representing a wide range of immunization partners convened in Atlanta, GA from May 15-16, 2012 for the inaugural National Adult Immunization Summit. The meeting called for solution-oriented discussion toward improving current immunization levels, implementing the 2011 National Vaccine Advisory Committee adult immunization recommendations, and capitalizing on new opportunities to improve coverage. Provisions in the federal health reform law that increase access to preventive services, including immunizations, and the increasing numbers of complementary vaccine providers such as pharmacists, create new opportunities to increase access for immunization services and improve coverage for adults. The Summit organized around five focal areas: empowering providers, quality and performance measures, increasing access and collaboration, educating patients, and informing decision-makers. These focal areas formed the basis of working groups, charged to coordinate efforts by the participating organizations to address gaps in the current immunization system. Summit participants identified priority themes to address as tasks during the coming year, including better communicating the value of immunizations to increase demand for immunizations, creating a central repository of resources for providers, patients, and others interested in improving adult immunization levels, examining performance and quality measures and evaluating means to use such measures to motivate vaccine providers, increasing engagement with employer and employee groups to increase awareness and demand for vaccinations, improving the use of immunization information systems and electronic health reports, decreasing barriers to all vaccine providers including pharmacists and community vaccinators, decreasing the complexity of the adult vaccine schedule where possible, engaging adult immunization champions and leaders in

  6. The World Summit for Social Development.

    PubMed

    1995-01-01

    The three goals of the UN World Summit for Social Development are to attack poverty, build solidarity, and create jobs. Unprecedented population growth has led to recognition of the need for a new, people-centered vision of development to counter the mutually reinforcing threats posed to world stability by poverty, unemployment, and social disintegration. This population growth may result in an inability of humanity to adapt and create unrelenting pressure on the world's natural resources. It has become increasingly recognized that improvements in the status of women will be vital to ensuring the future of humanity. Giving women the ability to decide their family size will eliminate hundreds of thousands of maternal deaths each year and will slow population growth while it increases women's productivity and control over resources. As the industrialized nations engage in unsustainable patterns of production and consumption, the lowest-income countries are caught in a "poverty-population-environment spiral." Although population growth is gradually slowing, the population of the world could double by 2050, with 95% of the growth occurring in developing countries. Concern is also mounting over the increasing urbanization of the world as well as the fact that while the populations of poor countries are becoming larger and younger, the population of industrialized countries are becoming older and smaller. The new vision of sustainable development involves generating economic growth, distributing benefits equitably, and allowing the regeneration of the environment. Without such security, the world can not achieve peace. The symptoms of social discrimination include social exclusion, which affects 90% of the world's population; sex and racial discrimination, which lowers the quality of life and increases life-threatening risks for women, indigenous people, and Blacks; violence and abuse, reflected in fact that the US has the highest incidence of murder in the world, in the

  7. People, poverty and the Earth Summit.

    PubMed

    Wheeler, J

    1992-01-01

    UNCED is about human beings managing their affairs so that all can achieve a reasonably good life without destroying the life-supporting environment. Currently human activities are approaching an upset of environmental balance through production of greenhouse gases, depletion of the ozone layer, and reduction of natural resources. Equity is the right to a decent life for the current human population of 5.5 billion and the future 10 billion expected within the next 50 years. A minimum use of environmental space/person is required. The Earth Summit will be a broad statement of environmental policy. Agenda 21 includes 115 action programs within 40 chapters. Separate conventions will be held on climate and biodiversity. The secretariat of UNCED has been working primarily with Agenda 21. Population issues are emphasized in Chapter 5 ("Demographic Dynamics and Sustainability") of the first section in Agenda 21 on Social and Economic Dimensions. The program areas include 1) research on the links between population, the environment, and development; 2) formulation by governments of integrated national policies on environment and development, which account for demographic trends, and promotion of population literacy; and 3) implementation of local level programs to ensure access to education and information and services in order to plan families freely and responsibly. Increases in funding for the population program are anticipated to be US $9 billion by the year 2000 and about US $7 billion/year until then. The year 2000 will bring with it a doubling of urban population in developing countries. There are challenges and opportunities to expand private sector job creation, education, clean water, and family health services. In addition to managing human settlements, there is also management of fragile ecosystems, which means relieving the pressure on these lands through urban migration or relocation to richer agricultural areas. The goal for agriculture is to triple food

  8. 75 FR 26807 - Sunshine Act Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-12

    ... [Federal Register Volume 75, Number 91 (Wednesday, May 12, 2010)] [Notices] [Page 26807] [FR Doc No: 2010-11392] NATIONAL COUNCIL ON DISABILITY Sunshine Act Meetings Dates and Times: May 13, 2010, 9... closed to the public. Matters to be Considered: National Summit on Disability Policy 2010. Portions Open...

  9. 75 FR 39974 - Sunshine Act Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-13

    ... From the Federal Register Online via the Government Publishing Office NATIONAL COUNCIL ON DISABILITY Sunshine Act Meetings DATE AND TIMES: July 28, 2010, 2 p.m.-6 p.m. PLACE: Renaissance Washington... CONSIDERED: (1) National Summit on Disability Policy 2010 Evaluation; (2) Council Strategic Planning. CONTACT...

  10. Elongate summit calderas as Neogene paleostress indicators in Antarctica

    USGS Publications Warehouse

    Paulsen, T.S.; Wilson, T.J.

    2007-01-01

    The orientations and ages of elongate summit calderas on major polygenetic volcanoes were compiled to document Miocene to Pleistocene Sh (minimum horizontal stress) directions on the western and northern flanks of the West Antarctic rift system. Miocene to Pleistocene summit calderas along the western Ross Sea show relatively consistent ENE long axis trends, which are at a high angle to the Transantarctic Mountain Front and parallel to the N77ºE Sh direction at Cape Roberts. The elongation directions of many Miocene to Pleistocene summit calderas in Marie Byrd Land parallel the alignment of polygenetic volcanoes in which they occur, except several Pleistocene calderas with consistent NNE to NE trends. The overall pattern of elongate calderas in Marie Byrd Land is probably due to a combination of structurally controlled orientations and regional stress fields in which Sh is oriented NNE to NE at a moderate to high angle to the trace of the West Antarctic rift system.

  11. Recent warming at Summit, Greenland: Global context and implications

    NASA Astrophysics Data System (ADS)

    McGrath, Daniel; Colgan, William; Bayou, Nicolas; Muto, Atsuhiro; Steffen, Konrad

    2013-05-01

    at Summit, Greenland suggest that the annual mean near-surface air temperature increased at 0.09 ± 0.01°C/a over the 1982-2011 climatology period. This rate of warming, six times the global average, places Summit in the 99th percentile of all globally observed warming trends over this period. The rate of warming at Summit is increasing over time. During the instrumental period (1987-2011), warming has been greatest in the winter season, although the implications of summer warming are more acute. The annual maximum elevation of the equilibrium line and dry snow line has risen at 44 and 35 m/a over the past 15 and 18 years, respectively. Extrapolation of this observed trend now suggests, with 95% confidence intervals, that the dry snow facies of the Greenland Ice Sheet will inevitably transition to percolation facies. There is a 50% probability of this transition occurring by 2025.

  12. Geologic Map of the Summit Region of Kilauea Volcano, Hawaii

    USGS Publications Warehouse

    Neal, Christina A.; Lockwood, John P.

    2003-01-01

    This report consists of a large map sheet and a pamphlet. The map shows the geology, some photographs, description of map units, and correlation of map units. The pamphlet gives the full text about the geologic map. The area covered by this map includes parts of four U.S. Geological Survey 7.5' topographic quadrangles (Kilauea Crater, Volcano, Ka`u Desert, and Makaopuhi). It encompasses the summit, upper rift zones, and Koa`e Fault System of Kilauea Volcano and a part of the adjacent, southeast flank of Mauna Loa Volcano. The map is dominated by products of eruptions from Kilauea Volcano, the southernmost of the five volcanoes on the Island of Hawai`i and one of the world's most active volcanoes. At its summit (1,243 m) is Kilauea Crater, a 3 km-by-5 km collapse caldera that formed, possibly over several centuries, between about 200 and 500 years ago. Radiating away from the summit caldera are two linear zones of intrusion and eruption, the east and the southwest rift zones. Repeated subaerial eruptions from the summit and rift zones have built a gently sloping, elongate shield volcano covering approximately 1,500 km2. Much of the volcano lies under water; the east rift zone extends 110 km from the summit to a depth of more than 5,000 m below sea level; whereas the southwest rift zone has a more limited submarine continuation. South of the summit caldera, mostly north-facing normal faults and open fractures of the Koa`e Fault System extend between the two rift zones. The Koa`e Fault System is interpreted as a tear-away structure that accommodates southward movement of Kilauea's flank in response to distension of the volcano perpendicular to the rift zones.

  13. Report from the 1st Cardiovascular Outcome Trial (CVOT) Summit of the Diabetes & Cardiovascular Disease (D&CVD) EASD Study Group.

    PubMed

    Schnell, Oliver; Standl, Eberhard; Catrinoiu, Doina; Genovese, Stefano; Lalic, Nebojsa; Skra, Jan; Valensi, Paul; Ceriello, Antonio

    2016-02-18

    The 1st Cardiovascular Outcome Trial (CVOT) Summit of the Diabetes & Cardiovascular Disease (D&CVD) EASD Study Group was held during the annual meeting on 30 October 2015 in Munich. This summit was organized in light of recently published and numerous ongoing CVOTs on diabetes, which have emerged in response to the FDA and the EMA Guidelines. The CVOT Summit stands as a novel conference setup, with the aim of serving as a reference meeting for all topics related to CVOTs in diabetes. Members of the steering committee of the D&CVD EASD Study Group constitute the backbone of the summit. It included presentations of key results on DPP-4 inhibitors, GLP-1-Analogues, SGLT-2 inhibitors, acarbose and insulins. Diabetologists' and cardiologists' perspective on the potential need of new study designs were also highlighted. Furthermore, panel discussions on the design of CVOTs on diabetes were included in the program. The D&CVD EASD Study Group will continue its activity. In-depth discussions and presentations of new CVOTs like LEADER, will be resumed at the 2nd CVOT on diabetes of the D&CVD EASD Study Group, which will be held from 20-22 October 2016 in Munich ( http://www.dcvd.org).

  14. 76 FR 50808 - Sunshine Act Meeting; August 18, 2011

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-16

    ... From the Federal Register Online via the Government Publishing Office TENNESSEE VALLEY AUTHORITY Sunshine Act Meeting; August 18, 2011 The TVA Board of Directors will hold a public meeting on August 18, 2011, at the TVA West Tower Auditorium, 400 West Summit Hill Drive, Knoxville, Tennessee, to consider...

  15. World Antibody-Drug Conjugate Summit, October 15-16, 2013, San Francisco, CA.

    PubMed

    Klinguer-Hamour, Christine; Strop, Pavel; Shah, Dhaval K; Ducry, Laurent; Xu, April; Beck, Alain

    2014-01-01

    The World Antibody-Drug Conjugate (WADC) Summits organized by Hanson Wade are currently the largest meetings fully dedicated to ADCs. The first global ADC Summit was organized in Boston in October 2010. Since 2011, two WADC are held every year in Frankfurt and San Francisco, respectively. The 2013 WADC San Francisco event was structured around plenary sessions with keynote speakers from AbbVie, Agensys, ImmunoGen, Immunomedics, Genentech, Pfizer and Seattle Genetics. Parallel tracks were also organized addressing ADC discovery, development and optimization of chemistry, manufacturing and control (CMC) issues. Discovery and process scientists, regulatory experts (US Food and Drug Administration), academics and clinicians were present, including representatives from biotechnology firms (Concortis, CytomX Therapeutics, Glykos, Evonik, Igenica, Innate Pharma, Mersana Therapeutics, Polytherics, Quanta Biodesign, Redwood Bioscience, Sutro Biopharma, SynAffix), pharmaceutical companies (Amgen, Genmab, Johnson and Johnson, MedImmune, Novartis, Progenics, Takeda) and contract research or manufacturing organizations (Baxter, Bayer, BSP Pharmaceuticals, Fujifilm/Diosynth, Lonza, Pierre Fabre Contract Manufacturing, Piramal, SAFC, SafeBridge).

  16. Introduction to ODP Leg 204 part II, processes at the summit of southern Hydrate Ridge

    NASA Astrophysics Data System (ADS)

    Bohrmann, G.; Odp Leg 204 Shipboard Scientific Party

    2003-04-01

    Since 1996, it has been known that the summit of Hydrate Ridge is a dynamic environment in which massive hydrate is forming at and near the seafloor and free gas is escaping vigorously into the ocean. In this presentation we summarize new data on subseafloor processes in this region obtained during ODP Leg 204. Several other presentations at this meeting provided additional discussion of the Leg 204 data and of the subseafloor processes they imply. During Leg 204, two sites were drilled at the summit. Integration of data from pressure core samples (PCS and HYACINTH autoclave system) with porewater chloride concentrations, electrical resistivity from logging while drilling (LWD) and infrared (IR) thermal imaging of cores on retrieval indicate that gas hydrate comprises as much as 30-40% of the total core volume in the upper 20-30 m. In addition, very high pore water chloride concentrations place constraints on rates of hydrate formation. The data imply high gas flux and movement of free gas through the gas hydrate stability zone (GHSZ). One possible explanation for the presence of free gas in the GHSZ is that water is locally exhausted during hydrate formation, leading to the presence free gas in the pore space. Although the occurrence of free gas associated with gas hydrates had been documented prior to Leg 204, Leg 204 is the first time that free gas at in situ conditions has been documented, an observation made possible by the the first use of the integrated HYACINTH pressure coring and density logging system.

  17. Introduction to Leg 204, part II - processes at the summit of southern

    NASA Astrophysics Data System (ADS)

    Bohrmann, G.; Trehu, A.; Torres, M.; Rack, F.; Milkov, A.; Schultheiss, P.; Collett, T.; Odp Leg 204 Shipboard Scientific Party (1) Presen

    2003-04-01

    Since 1996, it has been known that the summit of Hydrate Ridge is a dynamic environment in which massive hydrate is forming at and near the seafloor and free gas is escaping vigorously into the ocean. In this presentation we summarize new data on subseafloor processes in this region obtained during ODP Leg 204. Several other presentations at this meeting provided additional discussion of the Leg 204 data and of the subseafloor processes they imply. During Leg 204, two sites were drilled at the summit. Integration of data from pressure core samples (PCS and HYACINTH autoclave system) with porewater chloride concentrations, electrical resistivity from logging while drilling (LWD) and infrared (IR) thermal imaging of cores on retrieval indicate that gas hydrate comprises as much as 30-40% of the total core volume in the upper 20-30 m. In addition, very high pore water chloride concentrations place constraints on rates of hydrate formation. The data imply high gas flux and movement of free gas through the gas hydrate stability zone (GHSZ). One possible explanation for the presence of free gas in the GHSZ is that water is locally exhausted during hydrate formation, leading to the presence free gas in the pore space. Although the occurrence of free gas associated with gas hydrates had been documented prior to Leg 204, Leg 204 is the first time that free gas at in situ conditions has been documented, an observation made possible by the the first use of the integrated HYACINTH pressure coring and density logging system.

  18. World Antibody-Drug Conjugate Summit, October 15–16, 2013, San Francisco, CA

    PubMed Central

    Klinguer-Hamour, Christine; Strop, Pavel; Shah, Dhaval K; Ducry, Laurent; Xu, April; Beck, Alain

    2014-01-01

    The World Antibody-Drug Conjugate (WADC) Summits organized by Hanson Wade are currently the largest meetings fully dedicated to ADCs. The first global ADC Summit was organized in Boston in October 2010. Since 2011, two WADC are held every year in Frankfurt and San Francisco, respectively. The 2013 WADC San Francisco event was structured around plenary sessions with keynote speakers from AbbVie, Agensys, ImmunoGen, Immunomedics, Genentech, Pfizer and Seattle Genetics. Parallel tracks were also organized addressing ADC discovery, development and optimization of chemistry, manufacturing and control (CMC) issues. Discovery and process scientists, regulatory experts (US Food and Drug Administration), academics and clinicians were present, including representatives from biotechnology firms (Concortis, CytomX Therapeutics, Glykos, Evonik, Igenica, Innate Pharma, Mersana Therapeutics, Polytherics, Quanta Biodesign, Redwood Bioscience, Sutro Biopharma, SynAffix), pharmaceutical companies (Amgen, Genmab, Johnson and Johnson, MedImmune, Novartis, Progenics, Takeda) and contract research or manufacturing organizations (Baxter, Bayer, BSP Pharmaceuticals, Fujifilm/Diosynth, Lonza, Pierre Fabre Contract Manufacturing, Piramal, SAFC, SafeBridge). PMID:24423618

  19. Organochloride pesticides induced hepatic ABCG5/G8 expression and lipogenesis in Chinese patients with gallstone disease

    PubMed Central

    Ji, Guixiang; Xu, Cheng; Sun, Haidong; Liu, Qian; Hu, Hai; Gu, Aihua; Jiang, Zhao-Yan

    2016-01-01

    Background Organochlorine pesticides (OCPs) are one kind of persistent organic pollutants. Although they are reported to be associated with metabolic disorders, the underlying mechanism is unclear. We explored the association of OCPs with gallstone disease and its influence on hepatic lipid metabolism. Materials and Methods OCPs levels in omentum adipose tissues from patients with and without gallstone disease between 2008 and 2011 were measured by GC-MS. Differences of gene expression involved in hepatic lipid metabolism and hepatic lipids content were compared in liver biopsies between groups with high and low level of OCPs. Using HepG2 cell lines, the influence on hepatic lipid metabolism by individual OCP was evaluated in vitro. Results In all patients who were from non-occupational population, there were high levels of β-hexachlorocyclohexane (β-HCH) and p',p'-dichloroethylene (p',p'-DDE) accumulated in adipose tissues. Both β-HCH and p', p'-DDE levels were significantly higher in adipose tissues from patients with gallstone disease (294.3± 313.5 and 2222± 2279 ng/g of lipid) than gallstone-free controls (282.7± 449.0 and 2025±2664 ng/g of lipid, P< 0.01) and they were strongly related with gallstone disease (P for trend = 0.0004 and 0.0138). Furthermore, higher OCPs in adipose tissue led to increase in the expression of hepatic cholesterol transporters ABCG5 and G8 (+34% and +27%, P< 0.01) and higher cholesterol saturation index in gallbladder bile, and induced hepatic fatty acids synthesis, which was further confirmed in HepG2 cells. Conclusion OCPs might enhance hepatic secretion of cholesterol into bile via ABCG5/G8 which promoting gallstone disease as well as lipogenesis. PMID:27203212

  20. Genetic Variations at ABCG5/G8 Genes Modulate Plasma Lipids Concentrations in Patients with Familial Hypercholesterolemia

    PubMed Central

    Garcia-Rios, A; Perez-Martinez, P; Fuentes, F; Mata, P; Lopez-Miranda, J; Alonso, R; Rodriguez, F; Garcia-Olid, A; Ruano, J; Ordovas, JM; Perez-Jimenez, F

    2010-01-01

    Objective To investigate the association of four common single nucleotide polymorphisms (SNPs) at ABCG5 (i7892A>G, i18429C>T, Gln604GluC>G, i11836G>A) and five at ABCG8 (5U145T>G, Tyr54CysA>G, Asp19HisG>C, i14222T>C, and Thr400LysG>T) with plasma lipids concentrations and to explore the interaction between those SNPs and smoking in patients with FH. Methods and Results ABCG5/G8 SNPs were genotyped in 500 subjects with genetic diagnosis of FH. Carriers of the minor A allele at the ABCG5_i11836G>A SNP displayed significantly higher HDL-C concentrations (P=0.023) than G/G subjects. In addition, carriers of the minor G allele at the ABCG5_Gln604GluC>G SNP had significantly lower VLDL-C (P=0.011) and lower TG (P=0.017) concentrations than homozygous C/C. Interestingly, a significant gene-smoking interaction was found, in which carriers of the minor alleles at ABCG5 (i7892A>G, i18429C>T, i11836G>A) SNPs displayed significantly lower HDL-C, higher TC and higher TG respectively, only in smokers. On the other hand, non-smokers carriers of the minor alleles at ABCG5 (i18429C>T and Gln604GluC>G) SNPs had significantly lower TG concentrations (P=0.012 and P=0.035) compared with homozygous for the major allele. Conclusions Our data support the notion that ABCG5/G8 genetic variants modulate plasma lipids concentrations in patients with FH and confirm that this effect could be influenced by smoking. Therefore, these results suggest that gene-environmental interactions can affect the clinical phenotype of FH. PMID:20172523

  1. ACAT2 and ABCG5/G8 are both required for efficient cholesterol absorption in mice: evidence from thoracic lymph duct cannulation.

    PubMed

    Nguyen, Tam M; Sawyer, Janet K; Kelley, Kathryn L; Davis, Matthew A; Kent, Carol R; Rudel, Lawrence L

    2012-08-01

    The metabolic fate of newly absorbed cholesterol and phytosterol is orchestrated through adenosine triphosphate-binding cassette transporter G5 and G8 heterodimer (G5G8), and acyl CoA:cholesterol acyltransferase 2 (ACAT2). We hypothesized that intestinal G5G8 limits sterol absorption by reducing substrate availability for ACAT2 esterification and have attempted to define the roles of these two factors using gene deletion studies in mice. Male ACAT2(-/-), G5G8(-/-), ACAT2(-/-)G5G8(-/-) (DKO), and wild-type (WT) control mice were fed a diet with 20% of energy as palm oil and 0.2% (w/w) cholesterol. Sterol absorption efficiency was directly measured by monitoring the appearance of [(3)H]sitosterol and [(14)C]cholesterol tracers in lymph after thoracic lymph duct cannulation. The average percentage (± SEM) absorption of [(14)C]cholesterol after 8 h of lymph collection was 40.55 ± 0.76%, 19.41 ± 1.52%, 32.13 ± 1.60%, and 21.27 ± 1.35% for WT, ACAT2(-/-), G5G8(-/-), and DKO mice, respectively. [(3)H]sitosterol absorption was <2% in WT and ACAT2(-/-) mice, whereas it was up to 6.8% in G5G8(-/-) and DKO mice. G5G8(-/-) mice also produced chylomicrons with ∼70% less cholesterol ester mass than WT mice. In contrast to expectations, the data demonstrated that the absence of G5G8 led to decreased intestinal cholesterol esterification and reduced cholesterol transport efficiency. Intestinal G5G8 appeared to limit the absorption of phytosterols; ACAT2 more efficiently esterified cholesterol than phytosterols. The data indicate that handling of sterols by the intestine involves both G5G8 and ACAT2 but that an additional factor (possibly Niemann-Pick C1-like 1) may be key in determining absorption efficiency.

  2. Relation of summit deformation to east rift zone eruptions on Kilauea Volcano, Hawaii

    SciTech Connect

    Epp, D.; Decker, R.W.; Okamura, A.T.

    1983-07-01

    An inverse relationship exists between the summit deflation of Kilauea, as recorded by summit tilt, and the elevation of associated eruptive vents on the East Rift Zone. This relationship implies that East Rift eruptions drain the summit magma reservior to pressure levels that are dependent on the elevation of the eruptive vents.

  3. The effect of ABCG5/G8 polymorphisms on plasma HDL cholesterol levels depends on the ABCA1 gene variation in the Boston Puerto Rican Health Study

    USDA-ARS?s Scientific Manuscript database

    Background: ATP-binding cassette transporters G5/G8 have shown an association with HDL-C. One of the most likely mechanisms to explain those associations is through ABCA1. Objective: To assess whether the effect of ABCG5/G8 polymorphisms on HDL-C is dependent on ABCA1, we studied potential interacti...

  4. Echinococcus canadensis (Cestoda: Taeniidae) is a valid species consisting of the mitochondrial genotypes G6, G7, G8 and G10

    USDA-ARS?s Scientific Manuscript database

    The species status of Echinococcus canadensis has long been controversial, mainly because it consists of the mitochondrial genotypes G6, G7, G8 and G10 with different host affinity: G6 (camel strain) and G7 (pig strain) with domestic cycles and G8 (cervid strain) and G10 (Fennoscandian cervid strain...

  5. The World Summit of Harmonization on Traditional, Alternative and Complementary Medicine (TACM) in Lima, Peru

    PubMed Central

    Aguilar, José; Villar, Martha

    2010-01-01

    The World Summit of Harmonization on Traditional, Alternative and Complementary Medicine (TACM) was held in Lima, Peru, November 7–11, 2007, with almost 600 worldwide participants. This meeting was organized by Peruvian Medical College, the institution that affiliates and authorizes all physicians to practice medicine in Peru. The meeting included seven sections starting with an overview on the current status of the TACM. The second section included experiences from different countries on regulations and quality control in products and services used in the TACM. The worldwide experience of education and training in TACM was a very important part of the meeting in which speakers from Spain, Germany, Argentina, Italy, Brazil, Cuba and Peru shared their experience. The meeting included topics on homeopathy, acupuncture, mind–body medicine, neural therapy, chiropraxis, among others. Two final sessions were related to the ways of linking Traditional medicine to the national Health Systems in the Latin America countries and also the association between bio-commerce and TACM including intellectual properties and bio-piracy. PMID:18955348

  6. The World Summit of Harmonization on Traditional, Alternative and Complementary Medicine (TACM) in Lima, Peru.

    PubMed

    Gonzales, Gustavo F; Aguilar, José; Villar, Martha

    2010-06-01

    The World Summit of Harmonization on Traditional, Alternative and Complementary Medicine (TACM) was held in Lima, Peru, November 7-11, 2007, with almost 600 worldwide participants. This meeting was organized by Peruvian Medical College, the institution that affiliates and authorizes all physicians to practice medicine in Peru. The meeting included seven sections starting with an overview on the current status of the TACM. The second section included experiences from different countries on regulations and quality control in products and services used in the TACM. The worldwide experience of education and training in TACM was a very important part of the meeting in which speakers from Spain, Germany, Argentina, Italy, Brazil, Cuba and Peru shared their experience. The meeting included topics on homeopathy, acupuncture, mind-body medicine, neural therapy, chiropraxis, among others. Two final sessions were related to the ways of linking Traditional medicine to the national Health Systems in the Latin America countries and also the association between bio-commerce and TACM including intellectual properties and bio-piracy.

  7. 77 FR 23203 - Radio Broadcasting Services; Summit, MS

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-18

    ... COMMISSION 47 CFR Part 73 Radio Broadcasting Services; Summit, MS AGENCY: Federal Communications Commission... Subjects in 47 CFR Part 73 Radio, Radio broadcasting. Federal Communications Commission. Nazifa Sawez... Communications Commission proposes to amend 47 CFR Part 73 as follows: PART 73--RADIO BROADCAST SERVICES 1. The...

  8. 78 FR 36683 - Radio Broadcasting Services; Summit, Mississippi

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-19

    ... COMMISSION 47 CFR Part 73 Radio Broadcasting Services; Summit, Mississippi AGENCY: Federal Communications... U.S.C. 801(a)(1)(A). List of Subjects in 47 CFR Part 73 Radio, Radio broadcasting. Federal...--RADIO BROADCAST SERVICES 0 1. The authority citation for part 73 continues to read as follows:...

  9. International Summit on Prevention of Mental Retardation from Biomedical Causes.

    ERIC Educational Resources Information Center

    Koch, Jean, Ed.

    Proceedings from the International Summit on Prevention of Mental Retardation from Biomedical Causes are provided. After a list of participants and summary of the highlights of the conference, the keynote address by H. Moser is presented. The following 13 papers are provided along with workshop recommendations and a list of main points elicited…

  10. Securing Nuclear Materials: The 2010 Summit and Issues for Congress

    DTIC Science & Technology

    2010-04-16

    increased following the Chernobyl accident, the IAEA’s role in nuclear security activities increased following the September 11, 2001, terrorist...Materials: The 2010 Summit and Issues for Congress Congressional Research Service 17 United States deposits its instrument of ratification to the...recommended advice and consent on September 11, 2008. The Senate must approve implementing legislation before the United States deposits its

  11. Progress since the World Summit for Children: A Statistical Review.

    ERIC Educational Resources Information Center

    United Nations Children's Fund, New York, NY.

    One of the strengths of the 1990 World Summit for Children was its emphasis on goals to drive development and shape actions, and on the need to monitor progress, thereby transforming the way the world collected and processed data on children and women and creating a vital base and baseline for progress. In 2000, an exhaustive end-decade review of…

  12. What Makes a Great Teacher? PDK Summit Offers Many Ideas

    ERIC Educational Resources Information Center

    Young, Erin

    2009-01-01

    Creating change school requires courage. Great teachers can't be satisfied with managing change; they must be prepared to lead change, argues Thomas Guskey, keynote speaker at the 2008 Phi Delta Kappa Summit on High-Performing Educators and a professor of education at Georgetown College in Georgetown, Kentucky.

  13. What Makes a Great Teacher? PDK Summit Offers Many Ideas

    ERIC Educational Resources Information Center

    Young, Erin

    2009-01-01

    Creating change school requires courage. Great teachers can't be satisfied with managing change; they must be prepared to lead change, argues Thomas Guskey, keynote speaker at the 2008 Phi Delta Kappa Summit on High-Performing Educators and a professor of education at Georgetown College in Georgetown, Kentucky.

  14. Students Protest Lack of Representation at Spellings Summit

    ERIC Educational Resources Information Center

    Smith, Lauren

    2007-01-01

    Student lobbyists have sent Secretary of Education Margaret Spellings a letter scolding her for what they see as a minimizing of student representation at the higher-education summit held last week. The Department of Education responded by saying that students had indeed been invited to participate. The letter, which was signed by Jennifer S. Pae,…

  15. Structural map of the summit area of Kilauea Volcano, Hawaii

    SciTech Connect

    Not Available

    1982-01-01

    The map shows the faults, sets of fissures, eruptive vent lines and collapse features in the summit area of the volcano. It covers most of the USGS Kilauea Crater 7-1/2 minute quadrangle, together with parts of Volcano, Makaopuhi Crater, and Kau Desert 7-1/2 minute quadrangles. (ACR)

  16. Reaching the Summit: Deaf Adults as Essential Partners in Education

    ERIC Educational Resources Information Center

    Bourne-Firl, Bridgetta

    2016-01-01

    How do we reach the summit in terms of supporting the best transition possible for each young deaf or hard of hearing individual in the United States? Should professionals who are hearing work alone to succeed with deaf and hard of hearing students? No matter how good the intention, if we want deaf and hard of hearing students to transition from…

  17. Progress since the World Summit for Children: A Statistical Review.

    ERIC Educational Resources Information Center

    United Nations Children's Fund, New York, NY.

    One of the strengths of the 1990 World Summit for Children was its emphasis on goals to drive development and shape actions, and on the need to monitor progress, thereby transforming the way the world collected and processed data on children and women and creating a vital base and baseline for progress. In 2000, an exhaustive end-decade review of…

  18. Fair Student Funding Summit: Conference Proceedings and Recommendations for Action

    ERIC Educational Resources Information Center

    Education Resource Strategies, 2010

    2010-01-01

    On March 25-26, 2010, a cadre of urban education leaders gathered in Baltimore, Maryland for the "Fair Student Funding Summit," a conference that brought together districts that use weighted student funding (WSF) as an approach for allocating dollars to schools. Convened by Education Resource Strategies (ERS) and hosted by Baltimore City…

  19. Women's NGOs mobilize for population summit.

    PubMed

    1993-10-01

    The Center for Development and Population Activities (CEDPA) encouraged representatives from women's nongovernmental organizations (NGOs) to attend the 1994 International Conference on Population and Development (ICPD) in Cairo, Egypt. ICPD policy makers held issues meetings in September, 1993, for women's NGOs. the ICPD will have a direct bearing on women's issues such as access to family planning, reproductive health care, the fate of girls, and gender equality. 31 alumni of CEDPA met with UN officials and other NGO leaders at the second ICPD Preparatory Committee meeting in New York. CEDPA was encouraged that US policy supported women-managed and women-centered health services. CEDPA president Peggy Curlin recommends health and girl's education as the best means for improving the quality of life in developing countries. CEDPA has a Leadership and Advocacy Project, which promotes women's leadership in population policy at ICPD, regionally, and nationally. CEDPA recommends that women's NGOs and CEDPA link up with appropriate regional networks (in Bangladesh, Ghana, India, Kenya, Mexico, Nigeria, and Pakistan). Women can become involved in the ICPD by becoming an NGO representative to the conference. Women can also become involved by writing to CEDPA about their concerns regarding gender equity and women's empowerment, reproductive rights, girl child initiatives, and adequate resources for NGOs.

  20. Compliant membranes for the development of MEMS dual-backplate capacitive microphone using the SUMMiT V fabrication process.

    SciTech Connect

    Martin, David

    2005-11-01

    The objective of this project is the investigation of compliant membranes for the development of a MicroElectrical Mechanical Systems (MEMS) microphone using the Sandia Ultraplanar, Multilevel MEMS Technology (SUMMiT V) fabrication process. The microphone is a dual-backplate capacitive microphone utilizing electrostatic force feedback. The microphone consists of a diaphragm and two porous backplates, one on either side of the diaphragm. This forms a capacitor between the diaphragm and each backplate. As the incident pressure deflects the diaphragm, the value of each capacitor will change, thus resulting in an electrical output. Feedback may be used in this device by applying a voltage between the diaphragm and the backplates to balance the incident pressure keeping the diaphragm stationary. The SUMMiT V fabrication process is unique in that it can meet the fabrication requirements of this project. All five layers of polysilicon are used in the fabrication of this device. The SUMMiT V process has been optimized to provide low-stress mechanical layers that are ideal for the construction of the microphone's diaphragm. The use of chemical mechanical polishing in the SUMMiT V process results in extremely flat structural layers and uniform spacing between the layers, both of which are critical to the successful fabrication of the MEMS microphone. The MEMS capacitive microphone was fabricated at Sandia National Laboratories and post-processed, packaged, and tested at the University of Florida. The microphone demonstrates a flat frequency response, a linear response up to the designed limit, and a sensitivity that is close to the designed value. Future work will focus on characterization of additional devices, extending the frequency response measurements, and investigating the use of other types of interface circuitry.

  1. [The Saint-Petersburg summit of Group of Eight: the problems of infectious diseases and the ways of their solution].

    PubMed

    Onishchenko, G G

    2008-01-01

    In 2006, being the presiding country at the Group of Eight Summit for the first time, Russia proposed the issue of counteraction with infectious diseases as one of the priority issues. In addition to the realization of the priority National Health Project, which is to a large degree dedicated to the immunoprophylaxis of infectious diseases as well as the prevention and treatment of HIV-infection/AIDS and hepatites B and C, a meeting of the Presidium of Russian Federation State Council presided by President V. V. Putin, dedicated to the problem of HIV-infection epidemic spread, was held on April 21; the meeting resulted in the formation of Governmental Commission on the problems of HIV-infection/AIDS. On July 16, the leaders of Group of Eight during their meeting in Saint-Petersburg, discussed and validated the Declaration on counteraction with infectious diseases, reflecting the position of the leaders on the entire complex of problems connected with the spread of infectious diseases, and determining the main principles of the global strategy of counteraction with epidemics under the threats associated with the appearance of new infections, such as avian influenza, HIV-infection/AIDS, tuberculosis, and malaria. While preparing for the Summit, Russia made a range of suggestion aimed mostly on the reinforcement of possibilities to control infectious diseases in Eastern Europe and Central Asia. Practically all Russia's initiatives were supported by the partners, which was also reflected in the conclusive document of the Summit. Following Russian initiatives, Group of Eight intends to increase the effectiveness of international affords on the prevention and elimination of the consequences of natural disasters, including the use of fast response teams. To provide Russia's contribution to this initiative, modernized specialized antiepidemic teams will be used. Taking into consideration the present-day financial participation of Russian Federation in the realization of

  2. Recommendations from NASA's Operational and Research Musculoskeletal Summit

    NASA Technical Reports Server (NTRS)

    Jones, J. A.; Johnson-Throop, K. A.; Scheuring, R. A.; Walton, M. E.; Davis-Street, J. E.; Smaka, T.; McCulley, P. A.; Jones, J. A.; Stokes, C. R.; Parker, K. K.; hide

    2006-01-01

    Introduction: Continuously evolving medical standards of care, limited crew training time, and the inherent constraints of space flight necessitate regular revisions of the mission medical support infrastructure and methodology. A three-day Operational and Research Musculoskeletal Summit was held to review NASA s current strategy for preflight health maintenance and injury screening, risk mitigation for musculoskeletal injuries or syndromes, treatment methods during flight, and research topics to mitigate risks to astronaut health. The Summit also undertook consideration of the best evidence-based terrestrial musculoskeletal practices to recommend their adaptation for use in space. Methods: The types and frequencies of musculoskeletal injuries sustained by short- and long-duration astronauts were obtained from the Longitudinal Study of Astronaut Health. The Summit panel was comprised of experts from the clinical and research communities, as well as representatives from NASA Headquarters, the Astronaut corps, and the offices of JSC Medical Operations, JSC Human Adaptation and Countermeasures, Glenn Research Center Human Research, and Astronaut Strength Conditioning and Rehabilitation. Before the summit, panelists participated in a Web-based review of NASA s Space Medical Conditions List (SMCL). Results: The Summit generated seventy-five operational and research recommendations to the NASA Office of Space Medicine, including changes to the SMCL and to the musculoskeletal section of the ISS debrief questionnaire. From these recommendations, seven were assigned highest value and priority, and could be immediately adopted for the exploration architecture. Discussion: Optimized exercise and conditioning to improve performance and forestall musculoskeletal damage on orbit were the primary area of focus. Special attention was paid to exercise timing and muscle group specificity. The panel s recommendations are currently in various stages of consideration or integration

  3. Recommendations from NASA's Operational and Research Musculoskeletal Summit

    NASA Technical Reports Server (NTRS)

    Jones, J. A.; Johnson-Throop, K. A.; Scheuring, R. A.; Walton, M. E.; Davis-Street, J. E.; Smaka, T.; McCulley, P. A.; Jones, J. A.; Stokes, C. R.; Parker, K. K.; Wear, M.; Johnson-Throop, K. A.

    2006-01-01

    Introduction: Continuously evolving medical standards of care, limited crew training time, and the inherent constraints of space flight necessitate regular revisions of the mission medical support infrastructure and methodology. A three-day Operational and Research Musculoskeletal Summit was held to review NASA s current strategy for preflight health maintenance and injury screening, risk mitigation for musculoskeletal injuries or syndromes, treatment methods during flight, and research topics to mitigate risks to astronaut health. The Summit also undertook consideration of the best evidence-based terrestrial musculoskeletal practices to recommend their adaptation for use in space. Methods: The types and frequencies of musculoskeletal injuries sustained by short- and long-duration astronauts were obtained from the Longitudinal Study of Astronaut Health. The Summit panel was comprised of experts from the clinical and research communities, as well as representatives from NASA Headquarters, the Astronaut corps, and the offices of JSC Medical Operations, JSC Human Adaptation and Countermeasures, Glenn Research Center Human Research, and Astronaut Strength Conditioning and Rehabilitation. Before the summit, panelists participated in a Web-based review of NASA s Space Medical Conditions List (SMCL). Results: The Summit generated seventy-five operational and research recommendations to the NASA Office of Space Medicine, including changes to the SMCL and to the musculoskeletal section of the ISS debrief questionnaire. From these recommendations, seven were assigned highest value and priority, and could be immediately adopted for the exploration architecture. Discussion: Optimized exercise and conditioning to improve performance and forestall musculoskeletal damage on orbit were the primary area of focus. Special attention was paid to exercise timing and muscle group specificity. The panel s recommendations are currently in various stages of consideration or integration

  4. Monitoring of stage and velocity, for computation of discharge in the Summit Conduit near Summit, Illinois, 2010-2012

    USGS Publications Warehouse

    Johnson, Kevin K.; Goodwin, Greg E.

    2013-01-01

    Lake Michigan diversion accounting is the process used by the U. S. Army Corps of Engineers to quantify the amount of water that is diverted from the Lake Michigan watershed into the Illinois and Mississippi River Basins. A network of streamgages within the Chicago area waterway system monitor tributary river flows and the major river flow on the Chicago Sanitary and Ship Canal near Lemont as one of the instrumental tools used for Lake Michigan diversion accounting. The mean annual discharges recorded by these streamgages are used as additions or deductions to the mean annual discharge recorded by the main stream gaging station currently used in the Lake Michigan diversion accounting process, which is the Chicago Sanitary and Ship Canal near Lemont, Illinois (station number 05536890). A new stream gaging station, Summit Conduit near Summit, Illinois (station number 414757087490401), was installed on September 23, 2010, for the purpose of monitoring stage, velocity, and discharge through the Summit Conduit for the U.S. Army Corps of Engineers in accordance with Lake Michigan diversion accounting. Summit Conduit conveys flow from a small part of the lower Des Plaines River watershed underneath the Des Plaines River directly into the Chicago Sanitary and Ship Canal. Because the Summit Conduit discharges into the Chicago Sanitary and Ship Canal upstream from the stream gaging station at Lemont, Illinois, but does not contain flow diverted from the Lake Michigan watershed, it is considered a flow deduction to the discharge measured by the Lemont stream gaging station in the Lake Michigan diversion accounting process. This report offers a technical summary of the techniques and methods used for the collection and computation of the stage, velocity, and discharge data at the Summit Conduit near Summit, Illinois stream gaging station for the 2011 and 2012 Water Years. The stream gaging station Summit Conduit near Summit, Illinois (station number 414757087490401) is an

  5. Synthesis of water suitable as the MEPC.174(58) G8 influent water for testing ballast water management systems.

    PubMed

    D'Agostino, Fabio; Del Core, Marianna; Cappello, Simone; Mazzola, Salvatore; Sprovieri, Mario

    2015-10-01

    Here, we describe the methodologies adopted to ensure that natural seawater, used as "influent water" for the land test, complies with the requirement that should be fulfilled to show the efficacy of the new ballast water treatment system (BWTS). The new BWTS was located on the coast of SW Sicily (Italy), and the sampled seawater showed that bacteria and plankton were two orders of magnitude lower than requested. Integrated approaches for preparation of massive cultures of bacteria (Alcanivorax borkumensis and Marinobacter hydrocarbonoclasticus), algae (Tetraselmis suecica), rotifers (Brachionus plicatilis), and crustaceans (Artemia salina) suitable to ensure that 200 m(3) of water fulfilled the international guidelines of MEPC.174(58)G8 are here described. These methodologies allowed us to prepare the "influent water" in good agreement with guidelines and without specific problems arising from natural conditions (seasons, weather, etc.) which significantly affect the concentrations of organisms at sea. This approach also offered the chance to reliably run land tests once every two weeks.

  6. Demographic, geographic, and expedition determinants of reaching the summit of denali.

    PubMed

    McIntosh, Scott E; McDevitt, Marion; Rodway, George W; Dow, Jennifer; Grissom, Colin K

    2010-01-01

    Mount McKinley, or Denali as it is called by the native people of Alaska, is the highest mountain in North America and its summit is attempted by over 1000 climbers annually. Many factors affect the likelihood of achieving the summit of high peaks such as Denali: climber age, experience, weather, team characteristics, and many others. We analyzed the characteristics of mountaineers who gained the summit of Denali versus those who did not during the climbing seasons of 1990 to 2008. Of the 21,809 climbers who attempted to summit Denali during the study period, 11,297 (51.8%) achieved the summit. We found that male mountaineers were slightly more likely to attain the summit than females. Climbers older than 40 had a decreasing trend of summit success. Climbers from continents other than North America had better odds of achieving the summit. Our results help to better predict those who are more likely to achieve the summit of North America's highest peak. The information can be used by mountaineers during expedition planning so that team selection, route choice, and expedition style may be considered when evaluating chances for summit success. National Park Service administrative personnel and rescue staff may be able to identify climbing teams with a lower likelihood of summit success for proactive discussion or intervention prior to an expedition's departure for this unique and often very inhospitable mountain.

  7. Communication strategies to help reduce the prevalence of non-communicable diseases: proceedings from the inaugural IFIC Foundation Global Diet and Physical Activity Communications Summit.

    PubMed

    Fernstrom, Madelyn H; Reed, Kimberly A; Rahavi, Elizabeth B; Dooher, Carrie C

    2012-05-01

    Non-communicable diseases (NCDs), which include cardiovascular disease, cancer, and diabetes, all of which are associated with the common risk factors of poor diet and insufficient physical activity, caused 63% of all deaths globally in 2008. The increasing discussion of global NCDs, including at the 2011 United Nations General Assembly High-level Meeting on the Prevention and Control of Non-communicable Diseases, and a request for multi-stakeholder engagement, prompted the International Food Information Council Foundation to sponsor the Global Diet and Physical Activity Communications Summit: "Insights to Motivate Healthful, Active Lifestyles" on September 19, 2011, in New York City. The Summit brought together a diverse group of stakeholders, representing 34 nations from governments; communication, health, nutrition, and fitness professions; civil society; nonprofits; academia; and the private sector. The Summit provided expert insights and best practices for the use of science-based, behavior-focused communications to motivate individuals to achieve healthful, active lifestyles, with the goal of reducing the prevalence of NCDs. Presented here are some of the highlights and key findings from the Summit.

  8. Communication strategies to help reduce the prevalence of non-communicable diseases: Proceedings from the inaugural IFIC Foundation Global Diet and Physical Activity Communications Summit

    PubMed Central

    Fernstrom, Madelyn H; Reed, Kimberly A; Rahavi, Elizabeth B; Dooher, Carrie C

    2012-01-01

    Non-communicable diseases (NCDs), which include cardiovascular disease, cancer, and diabetes, all of which are associated with the common risk factors of poor diet and insufficient physical activity, caused 63% of all deaths globally in 2008. The increasing discussion of global NCDs, including at the 2011 United Nations General Assembly High-level Meeting on the Prevention and Control of Non-communicable Diseases, and a request for multi-stakeholder engagement, prompted the International Food Information Council Foundation to sponsor the Global Diet and Physical Activity Communications Summit: “Insights to Motivate Healthful, Active Lifestyles” on September 19, 2011, in New York City. The Summit brought together a diverse group of stakeholders, representing 34 nations from governments; communication, health, nutrition, and fitness professions; civil society; nonprofits; academia; and the private sector. The Summit provided expert insights and best practices for the use of science-based, behavior-focused communications to motivate individuals to achieve healthful, active lifestyles, with the goal of reducing the prevalence of NCDs. Presented here are some of the highlights and key findings from the Summit. PMID:22537216

  9. Full genomic characterization and phylogenetic analysis of a zoonotic human G8P[14] rotavirus strain detected in a sample from Guatemala.

    PubMed

    Gautam, Rashi; Mijatovic-Rustempasic, Slavica; Roy, Sunando; Esona, Mathew D; Lopez, Beatriz; Mencos, Yolanda; Rey-Benito, Gloria; Bowen, Michael D

    2015-07-01

    We report the genomic characterization of a rare human G8P[14] rotavirus strain, identified in a stool sample from Guatemala (GTM) during routine rotavirus surveillance. This strain was designated as RVA/Human-wt/GTM/2009726790/2009/G8P[14], with a genomic constellation of G8-P[14]-I2-R2-C2-M2-A13-N2-T6-E2-H3. The VP4 gene occupied lineage VII within the P[14] genotype. Phylogenetic analysis of each genome segment revealed close relatedness to several zoonotic simian, guanaco and bovine strains. Our findings suggest that strain RVA/Human-wt/GTM/2009726790/2009/G8P[14] is an example of a direct zoonotic transmission event. The results of this study reinforce the potential role of interspecies transmission and reassortment in generating novel and rare rotavirus strains which infect humans.

  10. Internal tidal currents over the summit of cross seamount

    USGS Publications Warehouse

    Noble, M.; Mullineaux, Lauren S.

    1989-01-01

    Spectral analysis of 46 days of record from a current meter deployed above the summit of Cross Seamount (approximately 300 km west of the Hawaiian Islands) indicates that the strongest current fluctuations were driven by the semidiurnal tide. The tides accounted for 28% of the variance in the current spectrum, were mainly baroclinic in character, and were propagated towards the west-northwest. The amplitude of the S2 current flowing parallel to the major axis of the current ellipse ranged between 4 and 9 cm-1 s. The S2 current was 1.5 times larger than the M2 current. This ratio is 4 times larger than is expected for this region of the Pacific and is not a general characteristics of flows over seamounts. Instantaneous current speeds over the seamount often exceeded 20 cm s-1 and were probably responsible for the small ripples observed on the sediment-covered regions of the summit. ?? 1990.

  11. Rehabilitation medicine summit: building research capacity Executive Summary

    PubMed Central

    Frontera, Walter R; Fuhrer, Marcus J; Jette, Alan M; Chan, Leighton; Cooper, Rory A; Duncan, Pamela W; Kemp, John D; Ottenbacher, Kenneth J; Peckham, P Hunter; Roth, Elliot J; Tate, Denise G

    2006-01-01

    The general objective of the "Rehabilitation Medicine Summit: Building Research Capacity" was to advance and promote research in medical rehabilitation by making recommendations to expand research capacity. The five elements of research capacity that guided the discussions were: 1) researchers; 2) research culture, environment, and infrastructure; 3) funding; 4) partnerships; and 5) metrics. The 100 participants included representatives of professional organizations, consumer groups, academic departments, researchers, governmental funding agencies, and the private sector. The small group discussions and plenary sessions generated an array of problems, possible solutions, and recommended actions. A post-Summit, multi-organizational initiative is called to pursue the agendas outlined in this report (see Additional File 1). PMID:16390550

  12. Cheryl Martin, Keynote - 2013 ARPA-E Energy Innovation Summit

    ScienceCinema

    Martin, Cheryl (Deputy Director of the Advanced Research Projects Agency-Energy (ARPA-E))

    2016-07-12

    The fourth annual ARPA-E Energy Innovation Summit was held in Washington D.C. in February, 2013. The event brought together key players from across the energy ecosystem - researchers, entrepreneurs, investors, corporate executives, and government officials - to share ideas for developing and deploying the next generation of energy technologies. Dr. Cheryl Martin is the Deputy Director of the Advanced Research Projects Agency--Energy (ARPA-E), gave the keynote address.

  13. [The Washington summit: orange light for genome editing?].

    PubMed

    Jordan, Bertrand

    2016-02-01

    The summit organised in early December 2015 considered in depth the various issues (technical, scientific, societal and ethical) raised by the prospect of genome editing using the extremely effective CRISPR system. Germline editing (for therapeutic or "enhancement" purposes) was stated to be irresponsible under current conditions, but the possibility that this could be considered in the future was not excluded; a mechanism for monitoring progress and possibly revising recommendations was proposed.

  14. The Pharma Summit 2010: competing in the future healthcare system.

    PubMed

    Kibble, Alexandra

    2010-04-01

    The Pharma Summit 2010, held in London, included topics covering the future changes and developments that are expected in the pharmaceutical industry. This conference report highlights selected presentations on various visions for the future of the pharma industry, the expected revolution in healthcare, changes with patients driving healthcare innovation, the future of healthcare technology, and the outlook for the global economy and emerging markets in the pharma industry.

  15. Cheryl Martin, Keynote - 2013 ARPA-E Energy Innovation Summit

    SciTech Connect

    Martin, Cheryl )

    2014-03-06

    The fourth annual ARPA-E Energy Innovation Summit was held in Washington D.C. in February, 2013. The event brought together key players from across the energy ecosystem - researchers, entrepreneurs, investors, corporate executives, and government officials - to share ideas for developing and deploying the next generation of energy technologies. Dr. Cheryl Martin is the Deputy Director of the Advanced Research Projects Agency--Energy (ARPA-E), gave the keynote address.

  16. Hepatic ABCG5/G8 overexpression substantially increases biliary cholesterol secretion but does not impact in vivo macrophage-to-feces RCT.

    PubMed

    Dikkers, Arne; de Boer, Jan Freark; Groen, Albert K; Tietge, Uwe J F

    2015-12-01

    Biliary cholesterol secretion is important for reverse cholesterol transport (RCT). ABCG5/G8 contribute most cholesterol mass secretion into bile. We investigated the impact of hepatic ABCG5/G8 on cholesterol metabolism and RCT. Biliary and fecal sterol excretion (FSE) as well as RCT were determined using wild-type controls, Abcg8 knockout mice, Abcg8 knockouts with adenovirus-mediated hepatocyte-specific Abcg8 reinstitution and hepatic Abcg5/g8 overexpression in wild-types. In Abcg8 knockouts, biliary cholesterol secretion was decreased by 75% (p < 0.001), while mass FSE and RCT were unchanged. Hepatic reinstitution of Abcg8 increased biliary cholesterol secretion 5-fold (p < 0.001) without changing FSE or overall RCT. Overexpression of both ABCG5/G8 elevated biliary cholesterol secretion 5-fold and doubled FSE (p < 0.001) without affecting overall RCT. ABCG5/G8 mediate mass biliary cholesterol secretion but not from a RCT-relevant pool. Intervention strategies aiming at increasing hepatic Abcg5/g8 expression for enhancing RCT are not likely to be successful. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  17. Investigations of The Stable Boundary Layer At Summit, Greenland

    NASA Astrophysics Data System (ADS)

    Ohmura, A.

    The investigation of the exchange processes in the stable atmospheric boundary layer has been hampered by lack of clean experimental data and by the separate treatment of radiative transfer and the turbulent heat transport. An experimental site was chosen at Summit, Greenland which is the highest point in the middle of the Greenland ice sheet. The site is located in the permanently dry snow zone the Greenland. The site is horizontal and very homogeneous with almost unlimited fetch. The atmospheric profiles both for the conventional scalar values and vertical fluxes are measured with a 50 m meteorological tower. The tower is also equipped by three radiation stations; one at the ground, the other at 50 m level; and the third mounted on a vertically mo- bile elevator to measure the divergence. A sensitive micro-barometer is installed at the foot of the tower for the observation of the pressure fluctuations which are caused by internal waves. The tower experiments are augmented by a wind-profiler and ra- diosonde observations to reach higher altitudes. Considerations on a length-scale as well as dimensionless gradients in a stable boundary layer will be presented. The site at Summit offers a very wide range of stability. In addition of extremely stable strat- ification at night and in winter as envisaged, extremely strong instability is found to prevail between 10 and 15 O'clock local time in summer, as net radiation at Summit turns strongly positive.

  18. Late-stage summit activity of Martian shield volcanoes

    NASA Technical Reports Server (NTRS)

    Mouginis-Mark, P. J.

    1982-01-01

    The preservation of morphologically fresh lava flows which pre-date the most recent episodes of caldera collapse at the summits of Ascraeus, Arsia and Olympus Montes indicates that explosive eruptions were not associated with this stage of Tharsis shield volcanism. The existence of resurfaced floor segments, complex wrinkle ridges, and lava terraces within the summit craters suggests that lava lakes comprised the dominant form of the intra-caldera activity. Multiple collapse episodes on Ascraeus and Olympus Montes are indicated by the nested summit craters. The most plausible cause of caldera collapse appears to be large-scale sub-terminal effusive activity, which is corroborated by the previously recognized existence of large lava flows on the flanks of these volcanoes. Due to the implied sequence of large-scale explosive (silicic) volcanism followed by effusive (basaltic) activity, it appears highly unlikely that ignimbrites or other forms of pyroclastic flows (previously proposed as possible deposits within the Olympus Mons aureole material) were ever erupted from the Tharsis Montes.

  19. Action on obesity: report of a mayo clinic national summit.

    PubMed

    Smith, Aynsley M; Lopez-Jimenez, Francisco; McMahon, M Molly; Thomas, Randal J; Wellik, Mary A; Jensen, Michael D; Hensrud, Donald D

    2005-04-01

    In May 2004, representatives from local, state, and national public and private organizations met in Rochester, Minn, for the Action on Obesity Summit hosted by Mayo Clinic. The overall goal of this summit was to identify creative and effective strategies to Increase the US population's physical activity and improve nutrition to reverse the increasing prevalence of obesity. Ideas generated from selected abstract presentations and breakout sessions were prioritized and incorporated into an action model (available at www.actiononobesity.org) deemed feasible for implementation into most communities. Highlights of the presentations included a company that reported lower than expected health care expenditures secondary to a work site wellness program, a national initiative to increase physical activity (www.americaonthemove.org), and innovative work site nutritional strategies. The implementation model that emerged contained certain themes. Coordinated action at all levels will be required to substantially impact the increasing prevalence of obesity. Educational messages should be simple, consistent, tailored, and linked to benefits. Healthy food options in vending machines and restaurants and increased opportunities for daily physical activity should be available in schools, work sites, and communities. Legislative and policy changes should promote physical activity and improve nutrition. Support for research should be encouraged and outcome measures for interventions documented. A second Action on Obesity Summit is planned for June 9 and 10, 2005, that will review the progress made in the intervening year and continue to refine the implementation model to help address the obesity epidemic, one of the greatest public health problems facing the United States.

  20. IS PROTOSTELLAR HEATING SUFFICIENT TO HALT FRAGMENTATION? A CASE STUDY OF THE MASSIVE PROTOCLUSTER G8.68-0.37

    SciTech Connect

    Longmore, S. N.; Pillai, T.; Keto, E.; Zhang, Q.; Qiu, K.

    2011-01-10

    If star formation proceeds by thermal fragmentation and the subsequent gravitational collapse of the individual fragments, how is it possible to form fragments massive enough for O and B stars in a typical star-forming molecular cloud where the Jeans mass is about 1 M{sub sun} at the typical densities (10{sup 4} cm{sup -3}) and temperatures (10 K)? We test the hypothesis that a first generation of low-mass stars may heat the gas enough that subsequent thermal fragmentation results in fragments {>=}10 M{sub sun}, sufficient to form B stars. We combine ATCA and Submillimeter Array observations of the massive star-forming region G8.68-0.37 with radiative transfer modeling to derive the present-day conditions in the region and use this to infer the conditions in the past, at the time of core formation. Assuming that the current mass/separation of the observed cores equals the fragmentation Jeans mass/length and the region's average density has not changed requires the gas temperature to have been 100 K at the time of fragmentation. The postulated first generation of low-mass stars would still be around today, but the number required to heat the cloud exceeds the limits imposed by the observations. Several lines of evidence suggest the observed cores in the region should eventually form O stars yet none have sufficient raw material. Even if feedback may have suppressed fragmentation, it was not sufficient to halt it to this extent. To develop into O stars, the cores must obtain additional mass from outside their observationally defined boundaries. The observations suggest that they are currently fed via infall from the very massive reservoir ({approx}1500 M{sub sun}) of gas in the larger parsec scale cloud around the star-forming cores. This suggests that massive stars do not form in the collapse of individual massive fragments, but rather in smaller fragments that themselves continue to gain mass by accretion from larger scales.

  1. Association of ATP binding cassette transporter G8 rs4148217 SNP and serum lipid levels in Mulao and Han nationalities.

    PubMed

    Li, Qing; Wei, Xian-Liang; Yin, Rui-Xing

    2012-05-01

    The association of ATP binding cassette transporter G8 gene (ABCG8) rs4148217 single nucleotide polymorphism (SNP) and serum lipid profiles is still controversial in diverse racial/ethnic groups. Mulao nationality is an isolated minority in China. The aim of this study was to evaluate the association of ABCG8 rs4148217 SNP and several environmental factors with serum lipid levels in the Guangxi Mulao and Han populations. A total of 634 subjects of Mulao nationality and 717 participants of Han nationality were randomly selected from our previous samples. Genotyping of the ABCG8 rs4148217 SNP was performed by polymerase chain reaction and restriction fragment length polymorphism combined with gel electrophoresis, and then confirmed by direct sequencing. The genotypic and allelic frequencies of ABCG8 rs4148217 SNP were different between the two nationalities (P < 0.01 for each), the frequency of A allele was higher in Mulao than in Han. The A allele carriers in Han had lower high-density lipoprotein cholesterol (HDL-C) and apolipoprotein (Apo) A1 levels than the A allele noncarriers (P < 0.05 for each), whereas the A allele carriers in Mulao had lower ApoA1 levels than the A allele noncarriers (P < 0.05). Subgroup analyses showed that the A allele carriers in Han had lower HDL-C and higher triglyceride (TG) levels in females but not in males than the A allele noncarriers (P < 0.05 for each), and the A allele carriers in Mulao had lower ApoA1 levels in females but not in males than the A allele noncarriers (P < 0.05). The levels of TG and HDL-C in Han, and ApoA1 in Mulao were associated with genotypes in females but not in males (P < 0.05-0.01). Serum lipid parameters were also correlated with several environmental factors (P < 0.05-0.001). The ABCG8 rs4148217 SNP is associated with serum TG, HDL-C and ApoA1 levels in our study populations, but this association is different between the Mulao and Han populations. There is a sex (female

  2. Climate Monitoring Network on Maunakea - Master Station at Summit and Lower Elevation Satellite Stations

    NASA Astrophysics Data System (ADS)

    McKenzie, M. M.; Klasner, F.; Giambelluca, T. W.; Businger, S.

    2014-12-01

    Maunakea, a dormant shield volcano on the Big Island of Hawai'i, rises 13,796 feet above sea level, making it the highest point in the Pacific Basin. From sea floor to summit, it's the tallest mountain in the world. The high elevation, low air and light pollution, as well as dry weather year round make it the best location in the world for astronomy observations. The summit is home to 13 ground based telescope facilities. Like all alpine regions, it is an extremely fragile and unique ecosystem because of the harsh conditions and short growing seasons located at high altitudes. The summit is home to several federal and/or state protected species. It supports 11 species of arthropods found nowhere else on Earth. Most noted of these is the Wēkiu bug, whose habitat has been altered by the infrastructural development on the mountain. Arthropod habitat model development has highlighted gaps in climate information, for example, lack of climate precipitation data, snow data and reliable temperature data. Furthermore, in tropical regions, precipitation is the most variable climate component due to topography and local winds. The telescopes collect weather data for the purpose of knowing when it is dry and clear for astronomical observation. Although existing weather stations associated with the telescopes meet some weather and climate monitoring needs, it cannot address the full range of issues needed due to technological limitation and site design. Precipitation does not occur often and is likely to be in the form of snow or ice. Snow cover data has not been directly recorded despite astronomical recording of other meteorological data that began in the1960s. Therefore, the need to monitor the weather and climate in a long-term and well-calibrated way is critical for management of the ecosystems on the slopes of Maunakea. Long-term weather and climate monitoring stations are the primary building blocks for research partnerships, which encourage collaboration and ultimately

  3. Proceedings of the AMCP Integrated Care Summit: population health and quality improvement in anaphylaxis.

    PubMed

    2014-01-01

    Anaphylaxis is a serious allergic reaction, often caused by food allergies, insect venom, medications, latex, or exercise. The condition is rapid in onset and may cause death. Because of the potential risk of death, it is critical to recognize anaphylaxis quickly and be prepared to treat it appropriately. To review the current trends and challenges related to anaphylaxis management, treatment, and prevention and explore strategies for how to improve access and awareness for patients who are at high risk for anaphylaxis. Fifteen stakeholders gathered on May 22, 2013, in Alexandria, Virginia, for a meeting to discuss population health and quality improvement in anaphylaxis convened by the Academy of Managed Care Pharmacy.Summit participants included managed care leaders, nurses, physicians, and organizations that advocate for consumers. Data on the clinical and financial impact of anaphylaxis are limited and are impacted by under diagnoses, underreporting, and miscoding of anaphylaxis. There is a significant need to increase awareness of the symptoms of anaphylaxis and ensure that patients at risk have access to available treatments. Additional education and training for both patients and health care professionals are needed to recognize the signs and symptoms of anaphylaxis and ensure the appropriate use of epinephrine auto injectors. Managed care companies have a need to better understand how to design and improve health benefits to support patients with anaphylaxis. Summit participants determined that there are opportunities to improve care for patients with anaphylaxis. The availability of epinephrine auto-injectors is not and should not be highly controlled, and the education and training of patients and health care professionals on the appropriate use of these devices are priorities. Attendees discussed numerous strategies that can be implemented by providers, health plans,and hospitals to improve patient care in this disease state.

  4. A WOUND CARE AND INTRAVENOUS ACCESS SUMMIT FOR ON-ORBIT CARE

    NASA Technical Reports Server (NTRS)

    Scheuring, R.; Paul, B.; Gillis, D.; Bacal, K.; McCulley, P.; Polk, J.; Johnson-Throop, K.

    2005-01-01

    Wound care issues and the ability to establish intravenous (IV) access among injured or ill crew members are a source of concern for NASA flight surgeons. Indeed, the microgravity environment and the remote nature of the International Space Station (ISS) pose unique challenges in diagnosing and treating an injured astronaut. Therefore, it is necessary to identify and adapt the best evidence based terrestrial practices regarding wound care, hemostasis, and IV access for use on the ISS. Methods: A panel of consultants was convened to evaluate the adequacy of the current ISS in-flight medical system for diagnosis and treatment of wounds and establishing IV access by a nonclinician crew medical officer. Participants were acknowledged experts in terrestrial wound care and/or operational medicine. Prior to the meeting, each panelist was encouraged to participate in a pre-summit online forum. Results: Eight external experts participated in a face-to-face meeting held at NASA-Johnson Space Center. Recommendations were made to augment the space station pharmacopoeia, as well as current wound care diagnostic, therapeutic, and deorbit criteria protocols. Additionally, suggestions were offered regarding IV access techniques and devices for use in the microgravity environment. Discussion: The results of the expert panel provide an evidence-based approach to the diagnosis and care of wounds in an injured astronaut on aboard the ISS. The results of the panel underscored the need for further research in wound therapy and IV access devices.

  5. A WOUND CARE AND INTRAVENOUS ACCESS SUMMIT FOR ON-ORBIT CARE

    NASA Technical Reports Server (NTRS)

    Scheuring, R.; Paul, B.; Gillis, D.; Bacal, K.; McCulley, P.; Polk, J.; Johnson-Throop, K.

    2005-01-01

    Wound care issues and the ability to establish intravenous (IV) access among injured or ill crew members are a source of concern for NASA flight surgeons. Indeed, the microgravity environment and the remote nature of the International Space Station (ISS) pose unique challenges in diagnosing and treating an injured astronaut. Therefore, it is necessary to identify and adapt the best evidence based terrestrial practices regarding wound care, hemostasis, and IV access for use on the ISS. Methods: A panel of consultants was convened to evaluate the adequacy of the current ISS in-flight medical system for diagnosis and treatment of wounds and establishing IV access by a nonclinician crew medical officer. Participants were acknowledged experts in terrestrial wound care and/or operational medicine. Prior to the meeting, each panelist was encouraged to participate in a pre-summit online forum. Results: Eight external experts participated in a face-to-face meeting held at NASA-Johnson Space Center. Recommendations were made to augment the space station pharmacopoeia, as well as current wound care diagnostic, therapeutic, and deorbit criteria protocols. Additionally, suggestions were offered regarding IV access techniques and devices for use in the microgravity environment. Discussion: The results of the expert panel provide an evidence-based approach to the diagnosis and care of wounds in an injured astronaut on aboard the ISS. The results of the panel underscored the need for further research in wound therapy and IV access devices.

  6. International Leaders Summit: using dialogue to Center the Conversation on the Education of Deaf Children and Youth in the 21st century.

    PubMed

    Anderson, John L

    2011-01-01

    Om July 18, 2010, the eve of the 21st International Congress on the Education of the Deaf (ICED 2010), the International Leaders Summit was held at the Center for Dialogue at Simon Fraser University, Vancouver, Canada. A total of 120 world leaders from 32 countries participated. Presenters, including students, led the conversation on current perspectives, teacher preparation, worldwide resources, and major issues affecting the education of d/Deaf and hard of hearing infants, children, and youth. Summit participants recognized that advances in detection, early intervention, and technology present challenges in meeting the needs of a student population more diverse than at any other stage in history. While it was acknowledged that needs differ in various parts of the world, there was a consensus that change is required to prepare students to handle challenges in the 21st century.

  7. A global perspective for managing obesity and improving health: conventional treatment and surgical options: 4th Annual Obesity Summit, London, April 2016

    PubMed Central

    Ahmad, Adeel Nazir; Edwards, Kimberley L

    2016-01-01

    4th Annual Obesity Summit, London, 12–14 April 2016 There are more than 1.9 billion overweight people worldwide, culminating in high rates of Type 2 diabetes; and cardiovascular, digestive and other health problems. This makes obesity a startling phenomenon and a significant global health epidemic. To address this, The 2016 Obesity Summit, 4th in the series of obesity-related annual events organized by EuroSciCon, was held from 12 to 14 April 2016 at Cineworld, The O2 in London. This conference set the stage for three days of stimulating high-quality presentations on the advancements in obesity in an informal academic setting. Approximately 156 delegates including students, researchers, healthcare professionals and scientists from 36 countries around the world attended the event. This meeting report summarizes some of the most outstanding presentations. PMID:28116126

  8. A global perspective for managing obesity and improving health: conventional treatment and surgical options: 4th Annual Obesity Summit, London, April 2016.

    PubMed

    Ahmad, Adeel Nazir; Edwards, Kimberley L

    2016-12-01

    4th Annual Obesity Summit, London, 12-14 April 2016 There are more than 1.9 billion overweight people worldwide, culminating in high rates of Type 2 diabetes; and cardiovascular, digestive and other health problems. This makes obesity a startling phenomenon and a significant global health epidemic. To address this, The 2016 Obesity Summit, 4th in the series of obesity-related annual events organized by EuroSciCon, was held from 12 to 14 April 2016 at Cineworld, The O2 in London. This conference set the stage for three days of stimulating high-quality presentations on the advancements in obesity in an informal academic setting. Approximately 156 delegates including students, researchers, healthcare professionals and scientists from 36 countries around the world attended the event. This meeting report summarizes some of the most outstanding presentations.

  9. 75 FR 34487 - Sunshine Act Meetings (by Conference Call)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-17

    ... From the Federal Register Online via the Government Publishing Office NATIONAL COUNCIL ON DISABILITY Sunshine Act Meetings (by Conference Call) DATE AND TIMES: June 25, 2010, 1 p.m.-3 p.m. PLACE: NCD... CONSIDERED: National Summit on Disability Policy 2010. CONTACT PERSON FOR MORE INFORMATION: Mark Quigley...

  10. G8 rotaviruses with conserved genotype constellations detected in Malawi over 10 years (1997–2007) display frequent gene reassortment among strains co-circulating in humans

    PubMed Central

    Nakagomi, Toyoko; Doan, Yen Hai; Dove, Winifred; Ngwira, Bagrey; Iturriza-Gómara, Miren; Nakagomi, Osamu

    2013-01-01

    Rotavirus A, the most common cause of severe diarrhoea in children worldwide, occurs in five major VP7 (G) and VP4 (P) genotype combinations, comprising G1P[8], G2P[4], G3P[8], G4P[8] and G9P[8]. However, G8, a common bovine rotavirus genotype, has been reported frequently among children in African countries. Surveillance of rotavirus gastroenteritis conducted in a sentinel hospital in Blantyre, Malawi between 1997 and 2007 provided a rare opportunity to examine the whole genotype constellation of G8 strains and their evolution over time. A sample of 27 (9.0 %) of 299 G8 strains was selected to represent each surveillance year and a range of P genotypes, which shifted in predominance from P[6] to P[4] and P[8] during the study period. Following cell culture adaptation, whole genome sequencing demonstrated that the genetic background of 26 strains possessed the DS-1 genotype constellation. A single G8P[6] strain was a reassortant in which both NSP2 and NSP5 genes from strains with the Wa genotype constellation had been inserted into a strain with the DS-1 genotype background. Phylogenetic analysis suggested frequent reassortment among co-circulating strains with the DS-1 genotype constellation. Little evidence was identified to suggest the introduction of contemporary bovine rotavirus genes into any of the 27 G8 strains examined. In conclusion, Malawian G8 strains are closely related to other human strains with the DS-1 genotype constellation. They have evolved over the last decade through genetic reassortment with other human rotaviruses, changing their VP4 genotypes while maintaining a conserved genotype constellation for the remaining structural and non-structural proteins. PMID:23407423

  11. UN food summit tries to focus world attention on hunger.

    PubMed

    Scommegna, P

    1996-11-01

    This article discusses the November 1996 World Food Summit in Rome, women's role as food producers, overconsumption, and justification for a world conference focus. The Summit was planned by the UN Food and Agriculture Organization and is to focus on how to provide people with food security and how to keep pace with growing needs without causing environmental damage. The Summit takes place during a time when 841 million of the world population are chronically undernourished, of which 200 million are children. Millions more suffer from contaminated food and water, micronutrient deficiencies, and blindness due to lack of vitamin A. Agricultural production in 88 countries is deficient. These countries cannot produce enough food to feed their populations an adequate diet and cannot afford to import needed food. These countries include China, India, and most of sub-Saharan Africa. World grain stocks have dropped to low levels, export prices for cereals have risen, and the world fish harvest has leveled off. Over the next 50 years the world must raise food for about 4 billion more people with a limited supply of land and uneven water resources. African countries must increase food production by 300%, Latin America by 80%, Asia by 69%, and North America by 30%. The former strategy of increasing yields with fertilizers is no longer effective and there is no other alternative. In developing countries women are the main producers of food for the family. Future policies must recognize women's role in food production. Poverty would decrease and food supplies increase if poor women were given access to credit and technical advice, education and health care, and a place in the center of the world agenda for increasing food productivity. The global food system is inequitably concentrated among few, and the food trade is increasingly controlled by multinationals. Overconsumption is as serious a problem as overpopulation.

  12. Climate Change Student Summits: A Model that Works (Invited)

    NASA Astrophysics Data System (ADS)

    Huffman, L. T.

    2013-12-01

    The C2S2: Climate Change Student Summit project has completed four years of activities plus a year-long longitudinal evaluation with demonstrated positive impacts beyond the life of the project on both students and teachers. This presentation will share the lessons learned about implementing this climate change science education program and suggest that it is a successful model that can be used to scale up from its Midwestern roots to achieve measurable national impact. A NOAA Environmental Literacy grant allowed ANDRILL (ANtarctic geological DRILLing) to grow a 2008 pilot program involving 2 Midwestern sites, to a program 4 years later involving 10 sites. The excellent geographical coverage included 9 of the U.S. National Climate Assessment regions defined by the U.S. Global Change Research Program. Through the delivery of two professional development (PD) workshops, a unique opportunity was provided for both formal and informal educators to engage their classrooms/audiences in understanding the complexities of climate change. For maximum contact hours, the PD experience was extended throughout the school year through the use of an online grouphub. Student teams were involved in a creative investigative science research and presentation experience culminating in a Climate Change Student Summit, an on-site capstone event including a videoconference connecting all sites. The success of this program was based on combining multiple aspects, such as encouraging the active involvement of scientists and early career researchers both in the professional development workshops and in the Student Summit. Another key factor was the close working relationships between informal and formal science entities, including involvement of informal science learning facilities and informal science education leaders. The program also created cutting-edge curriculum materials titled the ELF, (Environmental Literacy Framework with a focus on climate change), providing an earth systems

  13. Concentration, sources, and degradation of organic aerosol at Summit, Greenland

    NASA Astrophysics Data System (ADS)

    von Schneidemesser, Erika

    Characterization and understanding of the carbonaceous portion of the aerosol in the Arctic is limited. The objective of the research presented in this thesis was to improve the scope of knowledge pertaining to carbonaceous aerosols, in terms of atmospheric and snow concentrations, sources, and post-depositional processing. An extraction technique was developed to quantitatively identify a suite of organic compounds, typically observed in aerosol samples, at trace level concentrations in snow melt water samples. A field campaign of sampling and exposure experiments was carried out at Summit, Greenland. A 3-meter snow pit, sampled at 20 cm intervals, was analyzed for organic compounds and total organic carbon (TOC). The average concentration of TOC for the entire pit was 64 mug C kg-1. The quantified organic compounds comprised 6 to 24% of TOC throughout the layers. Median concentrations of the water insoluble individual organic compounds ranged from 0.14 ng kg-1 (hopane) to 2200 ng kg-1 (alkanoic acid) at any one depth. High-volume aerosol samples were collected over a six month period and analyzed for organics. Median concentrations ranged from 0.00045 ng kg-1 (hopane) to 0.23 ng kg-1 (levoglucosan) in the air samples. Source apportionment results from the aerosol samples indicate anthropogenic influence at Summit from biomass burning, fossil fuels, and vegetative detritus. The majority (>90%) of the organic carbon in the aerosol was estimated to be secondary organic aerosol. To investigate the post-depositional processing of organic compounds in snow, contaminant labeled snow was produced and exposed for up to 72 hours on the surface of the Greenland ice sheet at Summit. Degradation of alkanes, acids, and PAHs to a threshold concentration was observed. The threshold concentration, at which no further degradation was observed, ranged from 10 to 60% of the original (non-exposed) snow concentrations, depending on the reaction rate. This would indicate that a

  14. Geologic Mapping of the Summit Region of Alba Mons, Mars

    NASA Astrophysics Data System (ADS)

    Crown, D. A.; Berman, D. C.; Platz, T.

    2016-12-01

    Geologic mapping of the summit region of Alba Mons, the northernmost volcano in the Tharsis volcanic province of Mars, employs imaging and topographic datasets to examine eruptive activity, tectonism, and degradation in the caldera region and on the surrounding flanks. A 1:1M-scale USGS geologic map is being produced using Geographic Information Systems software and analysis tools. The map area (245-255°E, 32.5-47.5°N) includes six 1:500,000-scale Mars Transverse Mercator quadrangles (45112, 45107, 40112, 40107, 35112, and 35107) centered on the summit caldera complex and includes the main Alba Mons edifice, circumferential grabens encircling the volcano (Alba, Ceraunius, and Tantalus Fossae), and parts of the mid-flank and lower flank regions containing lava flows and dendritic valley networks. Populations of small, superposed impact craters are being used along with stratigraphic and cross-cutting relationships to derive relative and absolute age constraints. Initial mapping has been done for the caldera region to develop a preliminary unit and symbol scheme, focusing on the intra-caldera flows and flows on the upper flanks of the volcano extending from the caldera complex. Based on flow lobe patterns, multiple sequences of lava flow emplacement have occurred from a series of vents within the summit region. Geologic features have been mapped within and surrounding the caldera complex using THEMIS and CTX images. Based on cross-cutting relationships, a 65 km-across collapse depression on the southeast edge of the caldera complex represents the last stage of collapse. The rim of this depression shows diverse morphologic expression. To the south, scalloped, steep-walled areas presumably represent discrete, late-stage collapse events. Graben and scarps aligned with the eastern and western margins show the larger extent of deformation in summit materials related to this depression. Analyses of the morphology and topography of the depression floor indicate: a) the

  15. Genomic characterization of a rotavirus G8P[1] detected in a child with diarrhea reveal direct animal-to-human transmission.

    PubMed

    Martinez, Magaly; Phan, Tung Gia; Galeano, Maria Eugenia; Russomando, Graciela; Parreno, Viviana; Delwart, Eric; Parra, Gabriel I

    2014-10-01

    Group A rotavirus is a major cause of severe gastroenteritis in children and young animals. During a retrospective analysis of samples collected from Paraguayan children under 5 years old with diarrhea, and previously negative for rotavirus and norovirus, we detected the presence of bovine rotavirus sequences by viral metagenomics. Nucleic acid was extracted direct from stool sample and determined to be G8P[1]. The genomic analyzes revealed that the strain presents an Artiodactyl-like genome (G8-P[1]-I2-R2-C2-M1-Ax-N2-T6-E12-H3) suggesting a direct animal-to-human transmission.

  16. Environmental news: coverage of the Earth Summit by Brazilian newspapers.

    PubMed

    Reis, R

    1999-12-01

    This article examines how two important Brazilian newspapers (Floha de S. Paulo and O Globo) covered the UN Conference on Environment and Development (UNCED) or Earth Summit. The analysis will also determine the characteristics of the environmental media and its significance when it comes to coverage of environmental issues. This article provides historical background information on the environmental media in the US and in Brazil, contextual information on the Earth Summit, a content analysis of stories about UNCED published by the two Brazilian newspapers. Overall, 649 news items were used to determine the type of sources used, as well as the kind of issues covered. The analysis showed that government officials were the most frequently cited sources, while environmentalists and scientists were all but ignored as news sources. The analysis also indicated that economic issues were surprisingly prominent in the coverage. These results are compatible with the previous studies done in several countries and indicate that environmental media are still extremely reliant on "official" voices. The finding also highlight the fact that the range of issues covered by the environmental media largely reflects the perceived public agenda.

  17. Remarks from Congressional Leaders: Congresswoman Zoe Lofgren (2011 EFRC Summit)

    ScienceCinema

    Lofgren, Zoe (Congresswoman, California)

    2016-07-12

    Congresswoman Zoe Lofgren (D-California) spoke during the opening session of the EFRC Summit. The 2011 EFRC Summit and Forum brought together the EFRC community and science and policy leaders from universities, national laboratories, industry and government to discuss "Science for our Nation's Energy Future." In August 2009, the Office of Science established 46 Energy Frontier Research Centers. The EFRCs are collaborative research efforts intended to accelerate high-risk, high-reward fundamental research, the scientific basis for transformative energy technologies of the future. These Centers involve universities, national laboratories, nonprofit organizations, and for-profit firms, singly or in partnerships, selected by scientific peer review. They are funded at $2 to $5 million per year for a total planned DOE commitment of $777 million over the initial five-year award period, pending Congressional appropriations. These integrated, multi-investigator Centers are conducting fundamental research focusing on one or more of several “grand challenges” and use-inspired “basic research needs” recently identified in major strategic planning efforts by the scientific community. The purpose of the EFRCs is to integrate the talents and expertise of leading scientists in a setting designed to accelerate research that transforms the future of energy and the environment.

  18. Report of the 2014 Programming Models and Environments Summit

    SciTech Connect

    Heroux, Michael; Lethin, Richard

    2016-09-19

    Programming models and environments play the essential roles in high performance computing of enabling the conception, design, implementation and execution of science and engineering application codes. Programmer productivity is strongly influenced by the effectiveness of our programming models and environments, as is software sustainability since our codes have lifespans measured in decades, so the advent of new computing architectures, increased concurrency, concerns for resilience, and the increasing demands for high-fidelity, multi-physics, multi-scale and data-intensive computations mean that we have new challenges to address as part of our fundamental R&D requirements. Fortunately, we also have new tools and environments that make design, prototyping and delivery of new programming models easier than ever. The combination of new and challenging requirements and new, powerful toolsets enables significant synergies for the next generation of programming models and environments R&D. This report presents the topics discussed and results from the 2014 DOE Office of Science Advanced Scientific Computing Research (ASCR) Programming Models & Environments Summit, and subsequent discussions among the summit participants and contributors to topics in this report.

  19. Prior altitude experience of climbers attempting to summit Aconcagua.

    PubMed

    Borm, Nicholas; Van Roo, Jon D; Pesce, Carlos; Courtney, D Mark; Malik, Sanjeev; Lazio, Matthew P

    2011-01-01

    Aconcagua (6962 m) is one of the seven summits and the highest mountain outside of Asia. Climbers of varying experience are drawn to its nontechnical route. Our objective was to detail the prior altitude experience of climbers attempting to summit Aconcagua. We asked all climbers on the normal route of Aconcagua to complete questionnaires with demographics and prior high altitude experience while acclimatizing at Plaza de Mulas base camp during 9 nonconsecutive days in January 2009. 127 volunteers from 22 countries were enrolled. Mean age was 39.8 years and 88.2% were male. Median altitude at place of residence was 200 m (IQR: 30, 700). Median previous maximum altitude reached was 5895 m (IQR: 5365, 6150). 7.1% of climbers had never been above 4000 m. Median previous maximum sleeping altitude was 4800 m (IQR: 4300, 5486). 12.6% of climbers had never slept above 4000 m. Climbers who performed acclimatization treks spent a mean of 3.6 (2.5, 4.7) days at>3000 m in the previous 2 months. However, 50.4% of climbers performed no acclimatization treks. Although the majority of mountaineers who attempt Aconcagua have prior high altitude experience, a substantial minority has never been above 4000 m.

  20. Remarks from Congressional Leaders: Congressman Daniel Lipinski (2011 EFRC Summit)

    ScienceCinema

    Lipinski, Daniel (Congressman, Illinois)

    2016-07-12

    Congressman Daniel Lipinski (D-Illinois) spoke during the opening session of the EFRC Summit. The 2011 EFRC Summit and Forum brought together the EFRC community and science and policy leaders from universities, national laboratories, industry and government to discuss "Science for our Nation's Energy Future." In August 2009, the Office of Science established 46 Energy Frontier Research Centers. The EFRCs are collaborative research efforts intended to accelerate high-risk, high-reward fundamental research, the scientific basis for transformative energy technologies of the future. These Centers involve universities, national laboratories, nonprofit organizations, and for-profit firms, singly or in partnerships, selected by scientific peer review. They are funded at $2 to $5 million per year for a total planned DOE commitment of $777 million over the initial five-year award period, pending Congressional appropriations. These integrated, multi-investigator Centers are conducting fundamental research focusing on one or more of several “grand challenges” and use-inspired “basic research needs” recently identified in major strategic planning efforts by the scientific community. The purpose of the EFRCs is to integrate the talents and expertise of leading scientists in a setting designed to accelerate research that transforms the future of energy and the environment.

  1. Innovating a Sustainable Energy Future (2011 EFRC Summit)

    ScienceCinema

    Little, Mark (GE Global Research)

    2016-07-12

    The second speaker in the 2011 EFRC Summit session titled "Leading Perspectives in Energy Research" was Mark Little, Senior Vice President and Director of GE Global Research. He discussed the role that industry and in particular GE is playing as a partner in innovative energy research. The 2011 EFRC Summit and Forum brought together the EFRC community and science and policy leaders from universities, national laboratories, industry and government to discuss "Science for our Nation's Energy Future." In August 2009, the Office of Science established 46 Energy Frontier Research Centers. The EFRCs are collaborative research efforts intended to accelerate high-risk, high-reward fundamental research, the scientific basis for transformative energy technologies of the future. These Centers involve universities, national laboratories, nonprofit organizations, and for-profit firms, singly or in partnerships, selected by scientific peer review. They are funded at $2 to $5 million per year for a total planned DOE commitment of $777 million over the initial five-year award period, pending Congressional appropriations. These integrated, multi-investigator Centers are conducting fundamental research focusing on one or more of several “grand challenges” and use-inspired “basic research needs” recently identified in major strategic planning efforts by the scientific community. The purpose of the EFRCs is to integrate the talents and expertise of leading scientists in a setting designed to accelerate research that transforms the future of energy and the environment.

  2. Implications of the Earth Summit for ocean and coastal governance

    SciTech Connect

    Cicin-Sain, B.; Knecht, R.W.

    1993-10-01

    The Earth Summit (United Nations Conference on Environmental and Development (UNCED)), held in Rio de Janeiro in June 1992, was unique in the history of international conferences. Never before had so many heads of state participated in such an international negotiation. UNCED was also unique in both the breadth of environmental and development issues addressed and in the nature of the cross-cutting dimensions that were examined (for example, from poverty, population growth, and the role of indigenous peoples to unsustainable patterns of consumption (in the North), the role of women, and technology transfer). The chapter devoted to oceans and coasts was the longest and, in some ways, the most comprehensive, of the 40 chapters making up the action plan (Agenda 21) that was approved at Rio. This article provides an overview of the events leading up the Earth Summit, describes the principal outputs of the conference and their potential effects on ocean and coastal governance, discusses the main tension seen at UNCED and some of the negotiating processes, and, finally, considers current efforts at implementation of its recommendations. 43 refs., 1 fig.

  3. First-ever social summit struggles with toughest issues.

    PubMed

    De Sherbinin, A; Kalish, S

    1995-03-01

    More than one billion people live in extreme poverty, more than 120 million are officially unemployed, and the gap between rich and poor is increasing. Now that the Cold War has ended, we are more secure about international military security on the global scale, but less secure about personal and community-related issues and problems. In this context, the heads of state from around the world will convene in Copenhagen at the first World Summit on Social Development to discuss poverty, employment, and achieving the full participation of all groups in society. This summit will be the seventh of ten global conferences organized by the United Nations this decade, but it has garnered only minimal media attention. By early February, 102 heads of state had committed to attending, but it remains uncertain at what level the US will participate. The draft declaration specifies nine commitments to which countries will, in some form, assent in Copenhagen. These commitments express social goals such as achieving full equity and equality between men and women, promoting the social development of the least developed countries, reforming structural adjustment programs, and increasing the share of the world's resources devoted to social development. A tenth commitment assuring universal access to education and basic health services remains bracketed for decision in Copenhagen.

  4. The World Stem Cell Summit. Interview with Bernard Siegel.

    PubMed

    Siegel, Bernard

    2011-11-01

    Regenerative Medicine talks to Bernard Siegel, Executive Director of the Genetics Policy Institute (GPI) and founder of the annual World Stem Cell Summit. Bernard Siegel, JD, is the Founder and full-time Executive Director of the nonprofit Genetics Policy Institute (GPI), based in Wellington, FL, USA. He is the creator and co-chair of the World Stem Cell Summit series of global conferences and Editor-in-Chief of the World Stem Cell Report, which he also founded. He traded his 30-year courtroom career to found GPI, which leads the global 'Pro-Cures Movement' and Stem Cell Action Coalition. As a recognized policy expert on to stem cell research, regenerative medicine and cloning, Mr Siegel works with the world's leading stem cell researchers and advocates. Mr Siegel serves on the board of directors of the Coalition for Advancement of Medical Research (CAMR) and Americans for Cures Foundation. He also serves on the executive committee of the Alliance for Regenerative Medicine (ARM). He is a past co-chair of the Governmental Affairs Committee of the International Society for Stem Cell Research (ISSCR).

  5. Remarks from Congressional Leaders: Senator Jeff Bingaman (2011 EFRC Summit)

    ScienceCinema

    Bingaman, Jeff (Senator, New Mexico)

    2016-07-12

    During the opening session of the EFRC Summit, Senator Jeff Bingaman (D-NM) explained how the EFRCs play an important role in the U.S. energy innovation ecosystem. The 2011 EFRC Summit and Forum brought together the EFRC community and science and policy leaders from universities, national laboratories, industry and government to discuss "Science for our Nation's Energy Future." In August 2009, the Office of Science established 46 Energy Frontier Research Centers. The EFRCs are collaborative research efforts intended to accelerate high-risk, high-reward fundamental research, the scientific basis for transformative energy technologies of the future. These Centers involve universities, national laboratories, nonprofit organizations, and for-profit firms, singly or in partnerships, selected by scientific peer review. They are funded at $2 to $5 million per year for a total planned DOE commitment of $777 million over the initial five-year award period, pending Congressional appropriations. These integrated, multi-investigator Centers are conducting fundamental research focusing on one or more of several “grand challenges” and use-inspired “basic research needs” recently identified in major strategic planning efforts by the scientific community. The purpose of the EFRCs is to integrate the talents and expertise of leading scientists in a setting designed to accelerate research that transforms the future of energy and the environment.

  6. Whole grains and health: from theory to practice--highlights of The Grains for Health Foundation's Whole Grains Summit 2012.

    PubMed

    McKeown, Nicola M; Jacques, Paul F; Seal, Chris J; de Vries, Jan; Jonnalagadda, Satya S; Clemens, Roger; Webb, Densie; Murphy, Lee Anne; van Klinken, Jan-Willem; Topping, David; Murray, Robyn; Degeneffe, Dennis; Marquart, Leonard F

    2013-05-01

    The Grains for Health Foundation's Whole Grains Summit, held May 19-22, 2012 in Minneapolis, was the first meeting of its kind to convene >300 scientists, educators, food technologists, grain breeders, food manufacturers, marketers, health professionals, and regulators from around the world. Its goals were to identify potential avenues for collaborative efforts and formulate new approaches to whole-grains research and health communications that support global public health and business. This paper summarizes some of the challenges and opportunities that researchers and nutrition educators face in expanding the knowledge base on whole grains and health and in translating and disseminating that knowledge to consumers. The consensus of the summit was that effective, long-term, public-private partnerships are needed to reach across the globe and galvanize the whole-grains community to collaborate effectively in translating whole-grains science into strategies that increase the availability and affordability of more healthful, grain-based food products. A prerequisite of that is the need to build trust among diverse multidisciplinary professionals involved in the growing, producing, marketing, and regulating of whole-grain products and between the grain and public health communities.

  7. Molecular epidemiology of rotaviruses in Nigeria: detection of unusual strains with G2P[6] and G8P[1] specificities.

    PubMed

    Adah, M I; Wade, A; Taniguchi, K

    2001-11-01

    During an epidemiological study on rotaviruses among diarrheic children in the northeastern and middle belt regions of Nigeria, the distribution of G and P types was investigated in 127 stool specimens. By PCR G typing, the G type of rotaviruses in 97 samples was identified. Interestingly, an unusual G8 type, as well as common G1, G2, and G3 types, was detected more frequently (31 of 112; 27.7%). Eleven samples contained multiple G types, and a G9 strain (Bulumkutu) was identified for one of the probable mixed infections. In PCR P typing, P[6] was detected most frequently, P[8] being the second most common type, while the P type of 73 samples could not be identified. One rotavirus strain with a G8 type specificity could be cultivated in cell culture, and the P type of this strain was found to be P[1], which is usually carried by bovine strains. When the combinations of G and P types were examined, the unusual strains G2P[6] and G8P[1] were often identified. Sequence analysis was performed for the VP7 gene of the G9 strain Bulumkutu and the VP4 and VP7 genes of G8P[1] strain HMG035. The VP7 sequence of the Nigerian serotype G9 was more closely related to that of a Brazilian strain than to those of other African strains. The VP7 and VP4 genes of G8P[1] strain HMG035 were found to be very similar to that of a Thai bovine strain A5, suggesting that bovine strains may have been transmitted directly to humans. These results highlight an unexpected diversity among rotavirus strains in Nigeria and emphasize the need for further serological and genetic surveys on more rotavirus strains in African countries, including Nigeria.

  8. Interactions between common genetic polymorphisms in ABCG5/G8 and CYP7A1 on LDL cholesterol-lowering response to atorvastatin.

    PubMed

    Kajinami, Kouji; Brousseau, Margaret E; Ordovas, Jose M; Schaefer, Ernst J

    2004-08-01

    Cholesterol excretion by ATP binding cassette transporters G5 and G8 (ABCG5/G8) and bile acid biosynthesis by cholesterol 7alpha-hydroxylase (CYP7A1) are major pathways for the removal of cholesterol into bile. To investigate the interactions between common polymorphisms in ABCG5/G8 and CYP7A1 and statin response, we examined the relationships between five non-synonymous polymorphisms in ABCG5/G8 (Q604E, D19H, Y54C, T400K, and A632V) and a promoter variant in CYP7A1 (A-204C) in 337 hypercholesterolemic patients treated with atorvastatin 10mg. The ABCG8 H19 allele was significantly associated with a greater LDL cholesterol reduction relative to the wild type D19 allele (39.6% versus 36.6%, P = 0.043). This difference was enhanced in non-carriers of the CYP7A1 promoter polymorphism (42.7% versus 38.2%, P = 0.048), and was diminished in accordance with the number of CYP7A1 variant alleles (1.8% in heterozygotes and 0.2% in homozygotes). Combination analysis of these polymorphisms explained a greater percentage of LDL cholesterol response variation (8.5% difference across subgroups) than did single polymorphism analysis (4.2% in CYP7A1 and 3.0% in ABCG8 D19H). The other ABCG5/G8 polymorphisms did not show any significant interactions with the CYP7A1 polymorphism. We conclude that the ABCG8 H19 and CYP7A1 C-204 alleles appear to interact in a dose-dependent manner on atorvastatin response.

  9. Determinants of summiting success and acute mountain sickness on Mt Kilimanjaro (5895 m).

    PubMed

    Davies, Andrew J; Kalson, Nicholas S; Stokes, Suzy; Earl, Mark D; Whitehead, Adam G; Frost, Hannah; Tyrell-Marsh, Ian; Naylor, Jon

    2009-01-01

    To determine the incidence of acute mountain sickness (AMS), the frequency of summiting success, and the factors that affect these in trekkers on Kilimanjaro, one of the world's most summitted high-altitude peaks. The study group comprised 312 trekkers attempting Mt Kilimanjaro summit by the Marango Route. Trekkers ascended over 4 or 5 days along a fixed ascent profile, stopping at 3 huts on ascent (2700 m, 3700 m, and 4700 m) before attempting the summit. Researchers were stationed at each hut for 16 days. Each night we measured heart rate, respiratory rate, blood pressure, oxygen saturation, and Lake Louise Score. We recorded the highest altitude that trekkers reached on the mountain. Of 181 complete sets of data, 111 (61%) trekkers reached the summit, and 139 (77%) developed AMS. Physiological results were not related to summit success. The incidence of AMS and summiting success were similar in those on the 4- or 5-day route. Trekkers on the 5-day route who used acetazolamide were less likely to develop AMS and more likely to summit than were those not taking acetazolamide (P = <.05); this difference was not present with trekkers on the 4-day route. The risk of developing AMS is high on Mt Kilimanjaro. Although taking an extra day to acclimatize with the use of acetazolamide did provide some protection against AMS, ideally trekkers need a more gradual route profile for climbing this mountain.

  10. African American Community Education Partnership Summit: Focusing on Reading & Mathematics Achievement. Position Paper.

    ERIC Educational Resources Information Center

    Green, Robert L.

    This document was produced as a position paper for background for a summit convened by the San Francisco Unified School District (California) to focus on the education and achievement of African American students. The Education Partnership Summit had the principal goal of developing strategies and techniques to increase the mathematics and reading…

  11. Primative components, crustal assimilation, and magmatic degassing of the 2008 Kilauea summit eruption

    USGS Publications Warehouse

    Rowe, Michael C.; Thornber, Carl R.; Orr, Tim R.

    2015-01-01

    Simultaneous summit and rift zone eruptions at Kīlauea starting in 2008 reflect a shallow eruptive plumbing system inundated by a bourgeoning supply of new magma from depth. Olivine-hosted melt inclusions, host glass, and bulk lava compositions of magma erupted at both the summit and east rift zone demonstrate chemical continuity at both ends of a well-worn summit-to-rift pipeline. Analysis of glass within dense-cored lapilli erupted from the summit in March – August 2008 show these are not samplings of compositionally distinct magmas stored in the shallow summit magma reservoir, but instead result from remelting and assimilation of fragments from conduit wall and vent blocks. Summit pyroclasts show the predominant and most primitive component erupted to be a homogenous, relatively trace-element-depleted melt that is a compositionally indistinguishable from east rift lava. Based on a “top-down” model for the geochemical variation in east rift zone lava over the past 30 years, we suggest that the apparent absence of a 1982 enriched component in melt inclusions, as well as the proposed summit-rift zone connectivity based on sulfur and mineral chemistry, indicate that the last of the pre-1983 magma has been flushed out of the summit reservoir during the surge of mantle-derived magma from 2003-2007.

  12. The 6-Minute Walk Test as a Predictor of Summit Success on Denali.

    PubMed

    Shea, Katherine M; Ladd, Eric R; Lipman, Grant S; Bagley, Patrick; Pirrotta, Elizabeth A; Vongsachang, Hurnan; Wang, N Ewen; Auerbach, Paul S

    2016-03-01

    To test whether the 6-minute walk test (6MWT), including postexercise vital sign measurements and distance walked, predicts summit success on Denali, AK. This was a prospective observational study of healthy volunteers between the ages of 18 and 65 years who had been at 4267 m for less than 24 hours on Denali. Physiologic measurements were made after the 6MWT. Subjects then attempted to summit at their own pace and, at the time of descent, completed a Lake Louise Acute Mountain Sickness Questionnaire and reported maximum elevation reached. One hundred twenty-one participants enrolled in the study. Data were collected on 111 subjects (92% response rate), of whom 60% summited. On univariate analysis, there was no association between any postexercise vital sign and summit success. Specifically, there was no significant difference in the mean postexercise peripheral oxygen saturation (Spo2) between summiters (75%) and nonsummiters (74%; 95% CI, -3 to 1; P = .37). The distance a subject walked in 6 minutes (6MWTD) was longer in summiters (617 m) compared with nonsummiters (560 m; 95% CI, 7.6 to 106; P = .02). However, this significance was not maintained on a multivariate analysis performed to control for age, sex, and guide status (P = .08), leading to the conclusion that 6MWTD was not a robust predictor of summit success. This study did not show a correlation between postexercise oxygen saturation or 6MWTD and summit success on Denali. Copyright © 2016 Wilderness Medical Society. Published by Elsevier Inc. All rights reserved.

  13. National Summit on Economic & Financial Literacy (Washington, DC, March 3, 2005). Executive Summary

    ERIC Educational Resources Information Center

    National Council on Economic Education (NJ3), 2005

    2005-01-01

    On March 3, 2005, a gathering of policy-shapers, thought-leaders and decision-makers met for The National Summit on Economic and Financial Literacy to promote the benefits of economic and financial literacy to individuals, families, businesses and communities. The ultimate goal of the Summit was to ensure that everyone has the real-life skills…

  14. National Summit on Economic & Financial Literacy (Washington, DC, March 3, 2005). Executive Summary

    ERIC Educational Resources Information Center

    National Council on Economic Education (NJ3), 2005

    2005-01-01

    On March 3, 2005, a gathering of policy-shapers, thought-leaders and decision-makers met for The National Summit on Economic and Financial Literacy to promote the benefits of economic and financial literacy to individuals, families, businesses and communities. The ultimate goal of the Summit was to ensure that everyone has the real-life skills…

  15. Test Equity for Individuals Who Are Deaf or Hard of Hearing. PEPNet Test Equity Summit

    ERIC Educational Resources Information Center

    PEPNet-West, 2010

    2010-01-01

    This paper presents the highlights of the 2008 Test Equity Summit held in Bloomfield, Colorado last August 6-8, 2008. The 2008 Test Equity Summit convened by the Postsecondary Education Programs Network (PEPNet) identified and examined problems, challenges, and issues that academic and psychoeducational tests pose for individuals who are deaf or…

  16. Test Equity for Individuals Who Are Deaf or Hard of Hearing. PEPNet Test Equity Summit

    ERIC Educational Resources Information Center

    PEPNet-West, 2010

    2010-01-01

    This paper presents the highlights of the 2008 Test Equity Summit held in Bloomfield, Colorado last August 6-8, 2008. The 2008 Test Equity Summit convened by the Postsecondary Education Programs Network (PEPNet) identified and examined problems, challenges, and issues that academic and psychoeducational tests pose for individuals who are deaf or…

  17. A Global Imperative: The Report of the 21st Century Literacy Summit

    ERIC Educational Resources Information Center

    New Media Consortium, 2005

    2005-01-01

    This monograph, the report of the 21st Century Literacy Summit held in April 2005, presents a working definition for this emerging field, and details strategic priorities and recommendations that were the summit's major outcomes. The five strategic priorities--(1) Develop a Strategic Research Agenda; (2) Raise Awareness and Visibility of the…

  18. Community Colleges in the Evolving STEM Education Landscape: Summary of a Summit

    ERIC Educational Resources Information Center

    Olson, Steve; Labov, Jay B.

    2012-01-01

    The National Research Council (NRC) and National Academy of Engineering (NAE) have released a new report, "Community Colleges in the Evolving STEM Education Landscape: Summary of a Summit." Based on a national summit that was supported by the National Science Foundation and organized by the NRC and the NAE, the report highlights the importance of…

  19. It's Not a Matter of Time: Highlights from the 2011 Competency-Based Summit

    ERIC Educational Resources Information Center

    Sturgis, Chris; Patrick, Susan; Pittenger, Linda

    2011-01-01

    From Anchorage, Alaska, to Orlando, Florida, and from Gray, Maine, to Yuma, Arizona, one hundred competency-based innovators gathered at the Competency-Based Learning Summit in March 2011. Sponsored by the Council of Chief State School Officers (CCSSO) and the International Association for K-12 Online Learning (iNACOL), the Summit was developed in…

  20. Measurements of snow grain hydroxyl radical at Summit, Greenland

    NASA Astrophysics Data System (ADS)

    Anastasio, C.; Galbavy, E.; Hutterli, M.; Friel, D.; Bales, R.

    2004-12-01

    Sunlit snowpacks release a number of volatile organic compounds (VOCs) such as formaldehyde and other carbonyls, carboxylic acids, alkenes, and alkyl halides. It has been hypothesized that this flux of VOCs to the overlying atmosphere is in part due to reactions of hydroxyl radical (OH) with snowgrain organic matter. Recent laboratory measurements by Grannas et al. support this idea by showing that the photolysis of polar snow releases formaldehyde, and that this release is enhanced by the addition of nitrate, a photochemical source of OH. In addition to its effects on organic chemistry, OH is probably also important in other snowpack reactions such as the oxidation of halides to form volatile, reactive gaseous halogens. However, the possible role of OH in these reactions has not been quantified. To begin to address the importance of OH in snowpack chemistry, we have measured the photochemical formation of hydroxyl radicals on snow grains at Summit, Greenland during the spring and summer. Measurements were made using a chemical probe technique where benzoate is added to the snow sample in order to scavenge OH and convert it into p-hydroxybenzoate, which is measured by HPLC. We found that OH is formed on snow grains during both seasons and that the rate of formation in the summer was more than an order of magnitude greater than the typical springtime value. Expressed on a bulk (melted) snow volume basis, the average summer value was approximately 200 nM/hr. Assuming that this reactivity occurs within a snowgrain "quasi-liquid layer" (QLL) that represents approximately 0.001% of the bulk liquid volume, rates of OH photoformation in the QLL are on the order of 10 mM/hr. The possible implications of this enormous rate of OH formation for snowpack chemistry (e.g., for VOC release) will be discussed. We have also examined the relative importance of nitrate and hydrogen peroxide as sources of photoformed OH on snow grains at Summit. Based on quantum yields determined in

  1. An Earth Summit in a Large General Education Oceanography Class

    NASA Astrophysics Data System (ADS)

    Dodson, H.; Prothero, W. A.

    2001-12-01

    An Earth Summit approach in UCSB's undergraduate physical oceanography course has raised student interest level while it also supports the course goals of increased learner awareness of the process of science, and critical analysis of scientific claims. At the beginning of the quarter, each group of students chooses a country to represent in the Earth Summit. During the course of the quarter, these groups relate each of the class themes to their chosen country. Themes include 1) ocean basins and plate tectonics, 2) atmospheres, oceans and climate, and 3) fisheries. Students acquire and utilize Earth data to support their positions. Earth data sources include the "Our Dynamic Planet" CDROM (http://oceanography.geol.ucsb.edu/ODP_Advert/odp_onepage.htm), NOAA's ocean and climate database (http://ferret.wrc.noaa.gov/las/), WorldWatcher CD (http://www.worldwatcher.northwestern.edu/) and JPL's Seawinds web site (http://haifung.jpl.nasa.gov/index.html). During the atmospheres, oceans and climate theme, students choose from 12 mini-studies that use various kinds of on-line Earth data related to important global or regional phenomena relevant to the course. The Earth datasets that the students access for their analysis include: winds; atmospheric pressure; ocean chemistry; sea surface temperature; solar radiation; precipitation, etc. The first group of 6 mini-studies focus on atmosphere and ocean, and are: 1) global winds and surface currents, 2) atmosphere and ocean interactions, 3) stratospheric ozone depletion, 4) El Nino, 5) Indian monsoon, and 6) deep ocean circulation. The second group focus on the Earth's heat budget and climate and are: 1) influence of man's activities on the climate, 2) the greenhouse effect, 3) seasonal variation and the Earth's heat budget, 4) global warming, 5) paleoclimate, and 6) volcanoes and climate. The students use what they have learned in these mini-studies to address atmospheric and climatic issues pertinent to their specific Earth

  2. Whole genome analyses of African G2, G8, G9, and G12 rotavirus strains using sequence-independent amplification and 454® pyrosequencing.

    PubMed

    Jere, Khuzwayo C; Mlera, Luwanika; O'Neill, Hester G; Potgieter, A Christiaan; Page, Nicola A; Seheri, Mapaseka L; van Dijk, Alberdina A

    2011-11-01

    High mortality rates caused by rotaviruses are associated with several strains such as G2, G8, G9, and G12 rotaviruses. Rotaviruses with G9 and G12 genotypes emerged worldwide in the past two decades. G2 and G8 rotaviruses are however also characterized frequently across Africa. To understand the genetic constellation of African G2, G8, G9, and G12 rotavirus strains and their possible origin, sequence-independent cDNA synthesis, amplification, and 454(®) pyrosequencing of the whole genomes of five human African rotavirus strains were performed. RotaC and phylogenetic analysis were used to assign and confirm the genotypes of the strains. Strains RVA/Human-wt/MWI/1473/2001/G8P[4], RVA/Human-wt/ZAF/3203WC/2009/G2P[4], RVA/Human-wt/ZAF/3133WC/2009/G12P[4], RVA/Human-wt/ZAF/3176WC/2009/G12P[6], and RVA/Human-wt/ZAF/GR10924/1999/G9P[6] were assigned G8-P[4]-I2-R2-C2-M2-A2-N2-T2-E2-H2, G2-P[4]-I2-R2-C2-M2-A2-N2-T2-E2-H2, G12-P[4]-I1-R1-C1-M1-A1-N1-T1-E1-H1, G12-P[6]-I1-R1-C1-M1-A1-N1-T1-E1-H1, and G9-P[6]-I2-R2-C2-M2-A2-N2-T2-E2-H2 genotypes, respectively. The detection of both Wa- and DS-1-like genotypes in strain RVA/Human-wt/ZAF/3133WC/2009/G12P[4] and Wa-like, DS-1-like and P[6] genotypes in strain RVA/Human-wt/ZAF/GR10924/1999/G9P[6] implies that these two strains were generated through intergenogroup genome reassortment. The close similarity of the genome segments of strain RVA/Human-wt/MWI/1473/2001/G8P[4] to artiodactyl-like, human-bovine reassortant strains and human rotavirus strains suggests that it originated from or shares a common origin with bovine strains. It is therefore possible that this strain might have emerged through interspecies genome reassortment between human and artiodactyl rotaviruses. This study illustrates the swift characterization of all the 11 rotavirus genome segments by using a single set of universal primers for cDNA synthesis followed by 454(®) pyrosequencing and RotaC analysis.

  3. Optimizing the G8 Screening Tool for Older Patients With Cancer: Diagnostic Performance and Validation of a Six-Item Version

    PubMed Central

    Martinez-Tapia, Claudia; Canoui-Poitrine, Florence; Bastuji-Garin, Sylvie; Soubeyran, Pierre; Mathoulin-Pelissier, Simone; Tournigand, Christophe; Paillaud, Elena; Laurent, Marie

    2016-01-01

    Background. A multidimensional geriatric assessment (GA) is recommended in older cancer patients to inventory health problems and tailor treatment decisions accordingly but requires considerable time and human resources. The G8 is among the most sensitive screening tools for selecting patients warranting a full GA but has limited specificity. We sought to develop and validate an optimized version of the G8. Patients and Methods. We used a prospective cohort of cancer patients aged ≥70 years referred to geriatricians for GA (2007–2012: n = 729 [training set]; 2012–2014: n = 414 [validation set]). Abnormal GA was defined as at least one impaired domain across seven validated tests. Multiple correspondence analysis, multivariate logistic regression, and bootstrapped internal validation were performed sequentially. Results. The final model included six independent predictors for abnormal GA: weight loss, cognition/mood, performance status, self-rated health status, polypharmacy (≥6 medications per day), and history of heart failure/coronary heart disease. For the original G8, sensitivity was 87.2% (95% confidence interval, 84.3–89.7), specificity 57.7% (47.3–67.7), and area under the receiver-operating characteristic curve (AUROC) 86.5% (83.5–89.6). The modified G8 had corresponding values of 89.2% (86.5–91.5), 79.0% (69.4–86.6), and 91.6% (89.3; 93.9), with higher AUROC values for all tumor sites and stable properties on the validation set. Conclusion. A modified G8 screening tool exhibited better diagnostic performance with greater uniformity across cancer sites and required only six items. If these features are confirmed in other settings, the modified tool may facilitate selection for a full GA in older patients with cancer. Implications for Practice: Several screening tools have been developed to identify older patients with cancer likely to benefit from a complete geriatric assessment, but none combines appropriate sensitivity and specificity

  4. Management of osteoporosis in central and eastern Europe (CEE): conclusions of the "2nd Summit on Osteoporosis-CEE", 21-22 November 2008, Warsaw, Poland.

    PubMed

    Lorenc, Roman S; Resch, Heinrich

    2009-12-01

    In November 2008, the "2nd Summit on Osteoporosis-Central and Eastern Europe (CEE)" was held in Warsaw, Poland. Discussions at this meeting focused on the identification and discussion of diagnostic, preventive, and therapeutic measures used in CEE. Evaluated information was used to identify issues regarding diagnosis and therapy of osteoporosis in these countries to facilitate the subsequent setup of appropriate support and development strategies. The main debate was structured according to the following five subjects: (1) present status and future perspectives for implementation of FRAX(R) into local (CEE) diagnostic algorithms, (2) principles of drug selection in osteoporosis treatment in CEE countries, (3) nonpharmacological interventions in osteoporosis treatment and prophylaxis in CEE countries, (4) treatment benefit evaluation, and (5) cost-effectiveness and evaluation of reimbursement policies in CEE countries. The most important and substantial comments of the delegates are summarized in the present article. The multinational panel of experts with representatives from many CEE countries as well as Austria and Switzerland made the "2nd Summit on Osteoporosis-CEE" a perfect platform to identify issues and needs regarding diagnosis and therapy of osteoporosis as well as the cost-effectiveness of osteoporosis management in CEE countries. The information gained will serve as a basis for the development of strategies to resolve the identified issues at the "3rd Summit on Osteoporosis-CEE" in November 2009.

  5. Digestive cancer management in Asia: position statements: a report on GI Oncology Summit in 2011.

    PubMed

    Sung, Joseph J Y; Ng, Enders K W; Lin, Jaw-Town; Ho, K Y; Ji, Jia-Fu; Sugano, Kentaro; Poon, Ronnie T P; Chan, Anthony T C; Goh, Khean-Lee; Han, Kwang-Hyub; Chen, Leo L T; Wu, Kai-Chun; Ng, Simon S M; Bresalier, Robert S; Chan, Francis K L

    2012-09-01

    With the rising incidence of digestive cancers in the Asia Pacific region and the advancement in diagnosis, management and palliation in these conditions, the clinical burden on oncologists is ever increasing. This Summit meeting was called to discuss the optimal management of digestive cancers and the role of Gastroenterologists. Experts from Asia Pacific countries in the fields of medical, oncologic, surgical and endoscopic management of cancers in the esophagus, stomach, colon/rectum and the liver reviewed the literature and their practice. 18 position statements were drafted, debated and voted. It was agreed that the burden on GI cancer is increasing. More research will be warranted on chemotherapy, chemoprevention, cost-effectiveness of treatment and nutrition. Cancer management guidelines should be developed in this region when more clinical data are available. In order to improve care to patients, a multi-disciplinary team coordinated by a "cancer therapist" is proposed. This cancer therapist can be a gastroenterologist, a surgeon or any related discipline who have acquired core competence training. This training should include an attachment in a center-of-excellence in cancer management for no less than 12 months. The management of GI cancer should be an integrated multi-disciplinary approach and training for GI cancer therapists should be provided for. © 2012 Journal of Gastroenterology and Hepatology Foundation and Blackwell Publishing Asia Pty Ltd.

  6. World Antibody Drug Conjugate Summit Europe: February 21-23, 2011; Frankfurt, Germany.

    PubMed

    Beck, Alain; Senter, Peter; Chari, Ravi

    2011-01-01

    The World Antibody Drug Conjugate Summit Europe, organized by Biorbis/ Hanson Wade was held in Frankfurt, Germany on February 21-23, 2011. Antibody drug conjugates (ADCs), also called immunoconjugates, are becoming an increasingly important class of therapeutics as demonstrated by the attendance of nearly 100 delegates at this highly focused meeting. Updates on three ADCs that are in late-stage clinical development, trastuzumab emtansine (T-DM1), brentuximab vedotin (SGN-35) and inotuzumab ozogamicin (CMC-544), were presented by speakers from ImmunoGen, Genentech, Roche, Seattle Genetics and Pfizer. These ADCs have shown encouraging therapeutic effects against solid tumors (T-DM1) and hematological malignancies (SGN-35, CMC-544). The key feature of the new generation of ADCs is the effective combination of the cytotoxicity of natural or synthetic highly potent antineoplastic agents, tumor selective monoclonal antibodies and blood-stable optimized linkers. Early clinical data for ADCs were showcased by Progenics Pharmaceuticals (PSMA ADC), Celldex (CDX-011) and Biotest (BT-062). Takeda, MedImmune and sanofi-aventis outlined their strategies for process development and analytical characterization. In addition, presentations on duocarmycin based-ADCs, alpha emitting immunoconjugates and antibody-conjugated nanoparticles were given by representatives from Syntarga, Algeta and the University of Stuttgart, respectively.

  7. Major highlights of the CAR-TCR Summit, Boston, 2016.

    PubMed

    Golubovskaya, Vita; Berahovich, Robert; Xu, Shirley; Harto, Hizkia; Wu, Lijun

    2017-01-10

    Cellular immunotherapies such as CAR-T cell therapy and TCR-T cell therapy are relatively new, highly promising approaches for the treatment of cancer. In CAR-T cell therapy, a patient's T cells are engineered to express chimeric antigen receptors targeting tumor-associated cell surface antigens. In TCR-T cell therapy, the patient's T cells are engineered to express receptors targeting intracellular antigens. This report will summarize presentations from the recent CAR-TCR summit in Boston on September 13-16, 2016. These presentations were given by leaders in the field and many were divided into three streams: Discovery and Genetic T Cell Engineering; Translation and Clinical Development; and Manufacturing, Supply Chain and Commercialization. The report summarizes major pharmaceutical companies developing these novel therapies and provides challenges and perspectives for future therapeutic developments.

  8. Third Space Weather Summit Held for Industry and Government Agencies

    NASA Astrophysics Data System (ADS)

    Intriligator, Devrie S.

    2009-12-01

    The potential for space weather effects has been increasing significantly in recent years. For instance, in 2008 airlines flew about 8000 transpolar flights, which experience greater exposure to space weather than nontranspolar flights. This is up from 368 transpolar flights in 2000, and the number of such flights is expected to continue to grow. Transpolar flights are just one example of the diverse technologies susceptible to space weather effects identified by the National Research Council's Severe Space Weather Events—Understanding Societal and Economic Impacts: A Workshop Report (2008). To discuss issues related to the increasing need for reliable space weather information, experts from industry and government agencies met at the third summit of the Commercial Space Weather Interest Group (CSWIG) and the National Oceanic and Atmospheric Administration's (NOAA) Space Weather Prediction Center (SWPC), held 30 April 2009 during Space Weather Week (SWW), in Boulder, Colo.

  9. Photoformation of hydroxyl radical on snow grains at Summit, Greenland

    NASA Astrophysics Data System (ADS)

    Anastasio, Cort; Galbavy, Edward S.; Hutterli, Manuel A.; Burkhart, John F.; Friel, Donna K.

    We measured the photoformation of hydroxyl radical ( ṡOH) on snow grains at Summit, Greenland during the spring and summer. Midday rates of ṡOH formation in the snow phase in the summer range from 130 to 610nmolL-1h-1, expressed relative to the liquid equivalent volume of snow. Calculated formation rates of snow-grain ṡOH based on the photolysis of hydrogen peroxide and nitrate agree well with our measured rates during summer, indicating that there are probably not other major sources of ṡOH under these conditions. Throughout both the spring and summer, HOOH is by far the dominant source of snow-grain ṡOH; on average, HOOH produces approximately 100 times more ṡOH than does NO3-. Rates of ṡOH photoformation have a strong seasonal dependence and increase by approximately a factor of 10 between early spring and summer at midday. The rate of ṡOH photoformation on snow grains decreases rapidly with depth in the snowpack, with approximately 90% of photoformation occurring within the top 10 cm, although ṡOH formation occurs to depths below 20 cm. The formation of ṡOH on snow grains likely initiates a suite of reactions in the snowpack, including the transformation of organic carbon (OC) and oxidation of halides. The reaction of ṡOH with OC probably forms a number of volatile organic compounds (VOCs) that are potentially emitted into the atmospheric boundary layer. Indeed, our measured rates of ṡOH photoformation on snow grains are large enough that they could account for previously reported fluxes of VOCs from the snowpack at Summit, although the relative importance of thermal desorption and photochemical production for most of these VOCs still needs to be determined.

  10. The 2016 World Humanitarian Summit Report Card: Both Failing Marks and Substantive Gains for an Increasingly Globalized Humanitarian Landscape

    PubMed Central

    V. Canyon, Deon; Burkle, Frederick M.

    2016-01-01

    Outcomes of the World Humanitarian Summit were mixed with some refreshing new directions being endorsed and a lack of systemic reform. The selective agenda and OCHAs lack of success in engaging pre-meeting political participation not only hampered the Summit’s ability to deal with global issues and institutional reform, but also alienated it from leading aid agencies and governments. The UN’s failure to commit to humanitarian principles and global disarray of the humanitarian system indicates the need for extensive reform or a new global humanitarian body. This agency needs to employ a decentralized model to manage aid funds, assume coordination of international responses, resolve civil-military coordination, cater for people affected by both conflict and disasters, and professionalize the humanitarian career.  PMID:27679738

  11. Genetic diversity in three bovine-like human G8P[14] and G10P[14] rotaviruses suggests independent interspecies transmission events.

    PubMed

    Medici, Maria Cristina; Tummolo, Fabio; Bonica, Melisa Berenice; Heylen, Elisabeth; Zeller, Mark; Calderaro, Adriana; Matthijnssens, Jelle

    2015-05-01

    The group A rotavirus (RVA) P[14] genotype has been detected sporadically in humans and is thought to be acquired through zoonotic transmission. The present study describes the full-length genome analysis of two G8P[14] and one G10P[14] human RVAs detected in Italy. The strains possessed the typical bovine-like I2-R2-C2-M2-A3/A11-N2-T6-E2-H3 genotype constellation. All the segments of the two G8P[14] RVAs were most closely related to bovine(-like) strains but were relatively distant to each other, suggesting two independent interspecies transmission events. Likewise, the G10P[14] RVA gene segments were most similar to bovine(-like) RVAs but distinct from the G8 strains. The history of these strains probably involved the interspecies transmission of these viruses to humans from an as-yet-unidentified animal host, without evidence of reassortment events involving human RVAs. These results reinforce the potential of animal viruses to cross the host-species barrier, causing disease and increased viral genetic diversity in humans. © 2015 The Authors.

  12. Proceedings of the cardiac PET summit meeting 12 may 2014: Cardiac PET and SPECT instrumentation.

    PubMed

    Garcia, Ernest V

    2015-06-01

    Advances in PET and SPECT and imaging hardware and software are vastly improving the noninvasive evaluation of myocardial perfusion and function. PET perfusion imaging has benefitted from the introduction of novel detectors that now allow true 3D imaging, and precise attenuation correction (AC). These developments have also resulted in perfusion images with higher spatial and contrast resolution that may be acquired in shorter protocols and/or with less patient radiation exposure than traditional PET or SPECT studies. Hybrid PET/CT cameras utilize transmission computed tomographic (CT) scans for AC, and offer the additional clinical advantages of evaluating coronary calcium and myocardial anatomy but at a higher cost than PET scanners that use (68)Ge radioactive line sources. As cardiac PET systems continue to improve, dedicated cardiac SPECT systems are also undergoing a profound change in their design. The scintillation camera general purpose design is being replaced with systems with multiple detectors focused on the heart yielding 5 to 10 times the sensitivity of conventional SPECT. As a result, shorter acquisition times and/or lower tracer doses produce higher quality SPECT images than were possible before. This article reviews these concepts and compares the attributes of PET and SPECT instrumentation.

  13. 76 FR 550 - Second National Bed Bug Summit; Notice of Public Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-05

    ... implementation of the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA); the Federal Food, Drug, and Cosmetic Act (FFDCA), and the amendments to both of these major pesticide laws by the Food...

  14. Ice Hockey Summit II: zero tolerance for head hits and fighting.

    PubMed

    Smith, Aynsley M; Stuart, Michael J; Dodick, David W; Roberts, William O; Alford, Patrick W; Ashare, Alan B; Aubrey, Mark; Benson, Brian W; Burke, Chip J; Dick, Randall; Eickhoff, Chad; Emery, Carolyn A; Flashman, Laura A; Gaz, Daniel V; Giza, Chris C; Greenwald, Richard M; Herring, Stanley A; Hoshizaki, T Blaine; Hudziak, James J; Huston, John; Krause, David; LaVoi, Nicole; Leaf, Matt; Leddy, John J; MacPherson, Alison; McKee, Ann C; Mihalik, Jason P; Moessner, Anne M; Montelpare, William J; Putukian, Margot; Schneider, Kathryn J; Szalkowski, Ron; Tabrum, Mark; Whitehead, James R; Wiese-Bjornstal, Diane M

    2015-01-01

    This study aimed to present currently known basic science and on-ice influences of sport-related concussion (SRC) in hockey, building upon the Ice Hockey Summit I action plan (2011) to reduce SRC. The prior summit proceedings included an action plan intended to reduce SRC. As such, the proceedings from Summit I served as a point of departure for the science and discussion held during Summit II (Mayo Clinic, Rochester, MN, October 2013). Summit II focused on (1) Basic Science of Concussions in Ice Hockey: Taking Science Forward, (2) Acute and Chronic Concussion Care: Making a Difference, (3) Preventing Concussions via Behavior, Rules, Education, and Measuring Effectiveness, (4) Updates in Equipment: Their Relationship to Industry Standards, and (5) Policies and Plans at State, National, and Federal Levels To Reduce SRC. Action strategies derived from the presentations and discussion described in these sectors were voted on subsequently for purposes of prioritization. The following proceedings include the knowledge and research shared by invited faculty, many of whom are health care providers and clinical investigators. The Summit II evidence-based action plan emphasizes the rapidly evolving scientific content of hockey SRC. It includes the most highly prioritized strategies voted on for implementation to decrease concussion. The highest-priority action items identified from the Summit include the following: (1) eliminate head hits from all levels of ice hockey, (2) change body checking policies, and (3) eliminate fighting in all amateur and professional hockey.

  15. Comparison of UV irradiance measurements at Summit, Greenland; Barrow, Alaska; and South Pole, Antarctica

    NASA Astrophysics Data System (ADS)

    Bernhard, G.; Booth, C. R.; Ehramjian, J. C.

    2008-08-01

    An SUV-150B spectroradiometer for measuring solar ultraviolet (UV) irradiance was installed at Summit, Greenland, in August 2004. Here we compare the initial data from this new location with similar measurements from Barrow, Alaska, and South Pole. Measurements of irradiance at 345 nm performed at equivalent solar zenith angles (SZAs) are almost identical at Summit and South Pole. The good agreement can be explained with the similar location of the two sites on high-altitude ice caps with high surface albedo. Clouds attenuate irradiance at 345 nm at both sites by less than 6% on average, but can reduce irradiance at Barrow by more than 75%. Clear-sky measurements at Barrow are smaller than at Summit by 14% in spring and 36% in summer, mostly due to differences in surface albedo and altitude. Comparisons with model calculations indicate that aerosols can reduce clear-sky irradiance at Summit by 4 6%; aerosol influence is largest in April. Differences in total ozone at the three sites have a large influence on the UV Index. At South Pole, the UV Index is on average 20 80% larger during the ozone hole period than between January and March. At Summit, total ozone peaks in April and UV Indices in spring are on average 10 25% smaller than in the summer. Maximum UV Indices ever observed at Summit, Barrow, and South Pole are 6.7, 5.0, and 4.0, respectively. The larger value at Summit is due to the site's lower latitude. For comparable SZAs, average UV Indices measured during October and November at South Pole are 1.9 2.4 times larger than measurements during March and April at Summit. Average UV Indices at Summit are over 50% greater than at Barrow because of the larger cloud influence at Barrow.

  16. 2012 ARPA-E Energy Innovation Summit: Profiling Sheetak: Low Cost - Solid State Cooling

    SciTech Connect

    None Available

    2012-02-29

    The third annual ARPA-E Energy Innovation Summit was held in Washington D.C. in February, 2012. The event brought together key players from across the energy ecosystem - researchers, entrepreneurs, investors, corporate executives, and government officials - to share ideas for developing and deploying the next generation of energy technologies. A few videos were selected for showing during the Summit to attendees. These 'performer videos' highlight innovative research that is ongoing and related to the main topics of the Summit's sessions. Featured in this video are David Marcus, Founder of General Compression, and Eric Ingersoll, CEO of General Compression. Himanshu Pokharna, Vice President of Sheetak Uttam Ghoshal, President and CEO of Sheetak.

  17. 2012 ARPA-E Energy Innovation Summit: Profiling Sheetak: Low Cost - Solid State Cooling

    ScienceCinema

    None Available

    2016-07-12

    The third annual ARPA-E Energy Innovation Summit was held in Washington D.C. in February, 2012. The event brought together key players from across the energy ecosystem - researchers, entrepreneurs, investors, corporate executives, and government officials - to share ideas for developing and deploying the next generation of energy technologies. A few videos were selected for showing during the Summit to attendees. These 'performer videos' highlight innovative research that is ongoing and related to the main topics of the Summit's sessions. Featured in this video are David Marcus, Founder of General Compression, and Eric Ingersoll, CEO of General Compression. Himanshu Pokharna, Vice President of Sheetak Uttam Ghoshal, President and CEO of Sheetak.

  18. Replication Past the γ-Radiation-Induced Guanine-Thymine Cross-Link G[8,5-Me]T by Human and Yeast DNA Polymerase η

    PubMed Central

    Raychaudhury, Paromita; Basu, Ashis K.

    2010-01-01

    γ-Radiation-induced intrastrand guanine-thymine cross-link, G[8,5-Me]T, hinders replication in vitro and is mutagenic in mammalian cells. Herein we report in vitro translesion synthesis of G[8,5-Me]T by human and yeast DNA polymerase η (hPol η and yPol η). dAMP misincorporation opposite the cross-linked G by yPol η was preferred over correct incorporation of dCMP, but further extension was 100-fold less efficient for G∗:A compared to G∗:C. For hPol η, both incorporation and extension were more efficient with the correct nucleotides. To evaluate translesion synthesis in the presence of all four dNTPs, we have developed a plasmid-based DNA sequencing assay, which showed that yPol η was more error-prone. Mutational frequencies of yPol η and hPol η were 36% and 14%, respectively. Targeted G → T was the dominant mutation by both DNA polymerases. But yPol η induced targeted G → T in 23% frequency relative to 4% by hPol η. For yPol η, targeted G → T and G → C constituted 83% of the mutations. By contrast, with hPol η, semi-targeted mutations (7.2%), that is, mutations at bases near the lesion, occurred at equal frequency as the targeted mutations (6.9%). The kind of mutations detected with hPol η showed significant similarities with the mutational spectrum of G[8,5-Me]T in human embryonic kidney cells. PMID:20936176

  19. Surface energy budget responses to radiative forcing at Summit, Greenland

    NASA Astrophysics Data System (ADS)

    Miller, Nathaniel B.; Shupe, Matthew D.; Cox, Christopher J.; Noone, David; Persson, P. Ola G.; Steffen, Konrad

    2017-02-01

    Greenland Ice Sheet surface temperatures are controlled by an exchange of energy at the surface, which includes radiative, turbulent, and ground heat fluxes. Data collected by multiple projects are leveraged to calculate all surface energy budget (SEB) terms at Summit, Greenland, for the full annual cycle from July 2013 to June 2014 and extend to longer periods for the radiative and turbulent SEB terms. Radiative fluxes are measured directly by a suite of broadband radiometers. Turbulent sensible heat flux is estimated via the bulk aerodynamic and eddy correlation methods, and the turbulent latent heat flux is calculated via a two-level approach using measurements at 10 and 2 m. The subsurface heat flux is calculated using a string of thermistors buried in the snow pack. Extensive quality-control data processing produced a data set in which all terms of the SEB are present 75 % of the full annual cycle, despite the harsh conditions. By including a storage term for a near-surface layer, the SEB is balanced in this data set to within the aggregated uncertainties for the individual terms. November and August case studies illustrate that surface radiative forcing is driven by synoptically forced cloud characteristics, especially by low-level, liquid-bearing clouds. The annual cycle and seasonal diurnal cycles of all SEB components indicate that the non-radiative terms are anticorrelated to changes in the total radiative flux and are hence responding to cloud radiative forcing. Generally, the non-radiative SEB terms and the upwelling longwave radiation component compensate for changes in downwelling radiation, although exact partitioning of energy in the response terms varies with season and near-surface characteristics such as stability and moisture availability. Substantial surface warming from low-level clouds typically leads to a change from a very stable to a weakly stable near-surface regime with no solar radiation or from a weakly stable to neutral

  20. Genome sequence of Prevotella intermedia SUNY aB G8-9K-3, a biofilm forming strain with drug-resistance.

    PubMed

    Moon, Ji-Hoi; Kim, Minjung; Lee, Jae-Hyung

    Prevotella intermedia has long been known to be as the principal etiologic agent of periodontal diseases and associated with various systemic diseases. Previous studies showed that the intra-species difference exists in capacity of biofilm formation, antibiotic resistance, and serological reaction among P. intermedia strains. Here we report the genome sequence of P. intermedia SUNY aB G8-9K-3 (designated ATCC49046) that displays a relatively high antimicrobial resistant and biofilm-forming capacity. Genome sequencing information provides important clues in understanding the genetic bases of phenotypic differences among P. intermedia strains.

  1. Optimization Review: French Gulch/Wellington-Oro Mine Site Water Treatment Plant, Breckenridge, Summit County, Colorado

    EPA Pesticide Factsheets

    The French Gulch/Wellington-Oro Mine Site is located near the town of Breckenridge in Summit County, Colorado. Environmental contamination of surface water, groundwater, soil and sediment at the site resulted from mining activities dating to the 1880s.

  2. Spotlight on the Tribal Indoor Air Quality Summit Workgroup in Midwest Region 5

    EPA Pesticide Factsheets

    The Tribal IAQ Summit Workgroup uses a collaborative approach to increase the impact of tribes’ efforts to manage indoor air quality and improve community health for tribes in Illinois, Indiana, Michigan, Minnesota, Ohio and Wisconsin.

  3. TUESDAY: EPA Administrator to Give Keynote Address at Columbia Universitys Global Energy Summit in NYC

    EPA Pesticide Factsheets

    WASHINGTON - On Tuesday, EPA Administrator Gina McCarthy will give keynote remarks at Columbia University's Global Energy Summit in New York City. Administrator McCarthy will speak about the agency's actions to protect public health while encouragin

  4. TODAY: EPA Administrator to Give Keynote Address at Columbia Universitys Global Energy Summit in NYC

    EPA Pesticide Factsheets

    WASHINGTON - Today, EPA Administrator Gina McCarthy will give keynote remarks at Columbia University's Global Energy Summit in New York City. Administrator McCarthy will speak about the agency's actions to protect public health while encouraging eco

  5. The Science of Eliminating Health Disparities: Summary and Analysis of the NIH Summit Recommendations

    PubMed Central

    Rhee, Kyu B.; Williams, Kester; Sanchez, Idalia; Sy, Francisco S.; Stinson, Nathaniel; Ruffin, John

    2010-01-01

    In December 2008, the National Institutes of Health (NIH) sponsored the first NIH Summit showcasing its investment and contribution to health disparities research and unveiling a framework for moving this important field forward. The Summit, titled “The Science of Eliminating Health Disparities,” drew on extensive experience of experts leading health disparities research transformation in diverse fields. The Summit also provided a historic educational opportunity to contribute to health care reform. The theme, addressing disparities through integration of science, practice, and policy, introduced a paradigm for advancing research through transformational, translational, and transdisciplinary research. Engaging active participation throughout the Summit generated recommendations bridging science, practice, and policy, including action on social determinants of health, community engagement, broad partnerships, capacity-building, and media outreach. PMID:20147660

  6. Deep magma body beneath the summit and rift zones of kilauea volcano, hawaii.

    PubMed

    Delaney, P T; Fiske, R S; Miklius, A; Okamura, A T; Sako, M K

    1990-03-16

    A magnitude 7.2 earthquake in 1975 caused the south flank of Kilauea Volcano, Hawaii, to move seaward in response to slippage along a deep fault. Since then, a large part of the volcano's edifice has been adjusting to this perturbation. The summit of Kilauea extended at a rate of 0.26 meter per year until 1983, the south flank uplifted more than 0.5 meter, and the axes of both the volcano's rift zones extended and subsided; the summit continues to subside. These ground-surface motions have been remarkably steady and much more widespread than those caused by either recurrent inflation and deflation of the summit magma chamber or the episodic propagation of dikes into the rift zones. Kilauea's magmatic system is, therefore, probably deeper and more extensive than previously thought; the summit and both rift zones may be underlain by a thick, near vertical dike-like magma system at a depth of 3 to 9 kilometers.

  7. The science of eliminating health disparities: summary and analysis of the NIH summit recommendations.

    PubMed

    Dankwa-Mullan, Irene; Rhee, Kyu B; Williams, Kester; Sanchez, Idalia; Sy, Francisco S; Stinson, Nathaniel; Ruffin, John

    2010-04-01

    In December 2008, the National Institutes of Health (NIH) sponsored the first NIH Summit showcasing its investment and contribution to health disparities research and unveiling a framework for moving this important field forward. The Summit, titled "The Science of Eliminating Health Disparities," drew on extensive experience of experts leading health disparities research transformation in diverse fields. The Summit also provided a historic educational opportunity to contribute to health care reform. The theme, addressing disparities through integration of science, practice, and policy, introduced a paradigm for advancing research through transformational, translational, and transdisciplinary research. Engaging active participation throughout the Summit generated recommendations bridging science, practice, and policy, including action on social determinants of health, community engagement, broad partnerships, capacity-building, and media outreach.

  8. 75 FR 69468 - Metlife Moosic, PA, Metlife Clarks Summit, PA; Notice of Affirmative Determination Regarding...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-12

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF LABOR Employment and Training Administration Metlife Moosic, PA, Metlife Clarks Summit, PA; Notice of Affirmative Determination Regarding Application for Reconsideration By application dated August 2, 2010, the...

  9. Feasibility of Overland Traverse to Re-Supply Summit Camp: Fleet Configuration and Economic Analysis

    DTIC Science & Technology

    2011-03-01

    of re-supplying Summit Camp on the Greenland ice cap from Thule AFB via a 1200-mile (round trip) overland traverse was examined. The assessment...iv List of Figures and Tables Figures Figure 1. Map of Greenland showing approximate locations of Summit Camp, Kangerlussuaq and points of...Project 07-02, Greenland Traverse Feasibility Study and Planning. The work was performed by Dr. James H. Lever and Jason C. Weale of the Force

  10. Comparison of UV climates at Summit, Greenland; Barrow, Alaska and South Pole, Antarctica

    NASA Astrophysics Data System (ADS)

    Bernhard, G.; Booth, C. R.; Ehramjian, J. C.

    2008-03-01

    An SUV-150B spectroradiometer for measuring solar ultraviolet (UV) irradiance was installed at Summit, Greenland, in August 2004. Here we compare the initial data from this new location with similar measurements from Barrow, Alaska and South Pole. Measurements of irradiance at 345 nm performed at equivalent solar zenith angles (SZAs) are almost identical at Summit and South Pole. The good agreement can be explained with the similar location of the two sites on high-altitude ice caps with high surface albedo. Clouds have little impact at both sites, but can reduce irradiance at Barrow by more than 75%. Clear-sky measurements at Barrow are smaller than at Summit by 14% in spring and 36% in summer, mostly due to differences in surface albedo and altitude. Comparisons with model calculations indicate that aerosols can reduce clear-sky irradiance at 345 nm by 4-6%; aerosol influence is largest in April. Differences in total ozone at the three sites have a large influence on the UV Index. At South Pole, the UV Index is on average 20-80% larger during the ozone hole period than between January and March. At Summit, total ozone peaks in April and UV Indices in spring are on average 10-25% smaller than in the summer. Maximum UV Indices ever observed at Summit and South Pole are 6.7 and 4.0, respectively. The larger value at Summit is due to the site's lower latitude. For comparable SZAs, average UV Indices measured during October and November at South Pole are 1.9-2.4 times larger than measurements during March and April at Summit. Average UV Indices at Summit are over 50% greater than at Barrow because of the larger cloud influence at Barrow.

  11. Proceedings of the American Association of Oral and Maxillofacial Surgeons 2015 Research Summit.

    PubMed

    Cillo, Joseph E; Basi, David; Peacock, Zachary; Aghaloo, Tara; Bouloux, Gary; Dodson, Thomas; Edwards, Sean P; Kademani, Deepak

    2016-03-01

    The Fifth Biennial Research Summit of the American Association of Oral and Maxillofacial Surgeons and its Committee on Research Planning and Technology Assessment was held in Rosemont, Illinois on May 6 and 7, 2015. The goal of the symposium is to provide a forum for the most recent clinical and scientific advances to be brought to the specialty. The proceedings of the events of that summit are presented in this report.

  12. Participants in the First Florida Summit at the KSC Visitor Complex.

    NASA Technical Reports Server (NTRS)

    2000-01-01

    Senator Bob Graham (left), Center Director Roy Bridges (center) and Senator Connie Mack (right) take a break during the First Florida Space Summit, held at the Kennedy Space Center Visitor Complex. The summit featured key state officials and aerospace companies discussing the future of space as it relates to the State of Florida. Moderated by Bridges, the event also included State Senator Patsy Kurth, Representative Dave Weldon, and 45th Space Wing Commander Brig. Gen. Donald Pettit.

  13. Proceedings from the 2013 American Association of Oral and Maxillofacial Surgeons Research Summit.

    PubMed

    Peacock, Zachary S; Aghaloo, Tara; Bouloux, Gary F; Cillo, Joseph E; Hale, Robert G; Le, Anh D; Lee, Janice S; Kademani, Deepak

    2014-02-01

    The American Association of Oral and Maxillofacial Surgeons, the Oral and Maxillofacial Surgery Foundation, and the International Association of Oral and Maxillofacial Surgeons sponsored the fifth research summit, which convened on May 2 and 3 in Rosemont, Illinois. The Research Summits are convened biennially to facilitate the discussion and collaboration of oral and maxillofacial surgeons with clinical and basic science researchers in fields affecting the specialty. The goal is to advance the field of oral and maxillofacial surgery through exposure and education in topics that ultimately benefit the oral and maxillofacial surgical patient. This edition of the research summit included the topics of robotic surgery and antiresorptive-related osteonecrosis of the jaws (ARONJ). Most importantly, this research summit saw the development of research interest groups (RIGs) in the fields of anesthesia, maxillofacial oncology and reconstructive surgery, obstructive sleep apnea and orthognathic surgery, temporomandibular joint surgery, and trauma. These RIGs developed specific research goals with a plan to continue working on potential projects at the AAOMS Clinical Trials Course on May 7 to 9, 2013 at the University of Michigan in Ann Arbor. The summit program was developed by the AAOMS Committee on Research Planning and Technology Assessment. The charge of the committee is to encourage and promote research within the specialty and to encourage interdisciplinary collaboration. The research summit serves as a platform for oral and maxillofacial surgeons to lead the goal of advancement of research relevant to the specialty. This article provides an overview of the presentations that were made in the sessions on robotic surgery and ARONJ. The research summit keynote address and two additional presentations on patient registries are summarized and updates from the RIGs that were formed at the 2013 research summit are highlighted.

  14. 2012 Global Summit on Regulatory Science (GSRS-2012)--modernizing toxicology.

    PubMed

    Miller, Margaret A; Tong, Weida; Fan, Xiaohui; Slikker, William

    2013-01-01

    Regulatory science encompasses the tools, models, techniques, and studies needed to assess and evaluate product safety, efficacy, quality, and performance. Several recent publications have emphasized the role of regulatory science in improving global health, supporting economic development and fostering innovation. As for other scientific disciplines, research in regulatory science is the critical element underpinning the development and advancement of regulatory science as a modern scientific discipline. As a regulatory agency in the 21st century, the Food and Drug Administration (FDA) has an international component that underpins its domestic mission; foods, drugs, and devices are developed and imported to the United States from across the world. The Global Summit on Regulatory Science, an international conference for discussing innovative technologies, approaches, and partnerships that enhance the translation of basic science into regulatory applications, is providing leadership for the advancement of regulatory sciences within the global context. Held annually, this international conference provides a platform where regulators, policy makers, and bench scientists from various countries can exchange views on how to develop, apply, and implement innovative methodologies into regulatory assessments in their respective countries, as well as developing a harmonized strategy to improve global public health through global collaboration.

  15. Sand-Strewn Summit of 'Husband Hill' on Mars

    NASA Technical Reports Server (NTRS)

    2005-01-01

    Undulating bands of dark and light sand, sloping dunes, and scattered cobbles form an apron around a ridge of light-colored rock that stands in bold relief against distant plains, as viewed by NASA's 'Spirit' rover from the top of 'Husband Hill' on Mars. 'The view of the summit is spectacular where we are right now,' said geologist Larry Crumpler, with the New Mexico Museum of Natural History and Science, Albuquerque.

    From here, Spirit is looking north-northeast en route to examining more of the local geology of the 'Columbia Hills' in Gusev Crater. A few days after taking this picture, Spirit investigated the small, sinuous drifts on the left, located north-northeast of the rover's position in this image. The last previous time Spirit examined a drift was on the rim of 'Bonneville Crater' almost 500 martian days, or sols, ago, in March 2004.

    The largest light-colored rock in the foreground is nicknamed 'Whittaker.' The cliff beyond it and slightly to the left is nicknamed 'Tenzing.' The highest rock on the ridge ahead has been dubbed 'Hillary.' Science team members selected the nicknames in honor of the earliest climbers to scale Mount Everest on Earth. This view covers approximately 50 degrees of the compass from left to right. It is a mosaic assembled from frames Spirit took with the panoramic camera on sol 603 (Sept. 13, 2005). It was taken through a blue (430-nanometer) filter and is presented as a cylindrical projection.

  16. Accumulation mapping at Summit, Greenland using an autonomous rover (Invited)

    NASA Astrophysics Data System (ADS)

    Robertson, M. E.; Koenig, L.; Trisca, G.; Marshall, H.

    2013-12-01

    New and advanced technologies in firn studies continue to emerge in both remote sensing tools and the platforms that deploy them. A new autonomous robot, called GROVER, was tested and deployed in May 2013 at Summit, Greenland. The robot operates a 8 GHz bandwidth frequency-modulated continuous-wave (FMCW) radar capable of imaging the near-surface firn at very high vertical resolution (~2 cm). The radar penetrated to depths of ~10 m with identifiable annual layers. Here we briefly describe GROVER's capabilities and applications for firn studies. We present the nearly 25 km of accumulation measurements derived from annual layering in the radar echograms. The GROVER-made measurements are compared to radar-derived accumulation from previous studies using a similar FMCW system in 2009 pulled by a snowmobile, as well as, with airborne laser altimetry and GPS measurements taken over the roved lines. Discrepancies and similarities between the measurement methods are investigated and explained. The robot-based firn echograms are also used to estimate the depth and extent of the 2012 melt layer over the roved lines. Near-surface radars have proven useful for monitoring and calculating snow and firn processes such as SWE and accumulation; moving firn studies onto an autonomous rover can reduce costs and increase spatial coverage for validation of future satellite missions.

  17. Cosmogenic He in terrestrial rocks: The summit lavas of Maui.

    PubMed

    Craig, H; Poreda, R J

    1986-04-01

    We have identified terrestrial cosmic rayproduced (3)He in three lava flows on the crest of Haleakala Volcano on Maui, 3 km above sea level, and approximately 0.5 million years old. Although these lavas, like all oceanic basalts, contain primordial (3)He from the mantle, the "cosmogenic" component ((3)He(C)) can be identified unambiguously because it is extractable only by high-temperature vacuum fusion. In contrast, a large fraction of the mantle helium resides in fluid inclusions and can be extracted by vacuum crushing, leaving a residual component with (3)He/(4)He ratios as high as 75x those in the atmosphere, which can be liberated by melting the crushed grains. Cosmogenic (3)He is present in both olivines and clinopyroxenes at 0.8-1.2 x 10(-12) ml(STP)/g and constitutes 75% +/- 5% of the total (3)He present. The observed (3)He(C) levels require a cosmic ray exposure age of only some 64,000 years, much less than the actual age of the lavas, if there is no erosion. Using a model that includes effects of uplift or submergence as well as erosion, we calculate an apparent "erosion rate" of the order of 8.5 m/10(6) years for the western rim of the summit crater, as an example of the application of measurements of cosmogenic rare gases to terrestrial geological problems.

  18. Sand-Strewn Summit of 'Husband Hill' on Mars

    NASA Technical Reports Server (NTRS)

    2005-01-01

    Undulating bands of dark and light sand, sloping dunes, and scattered cobbles form an apron around a ridge of light-colored rock that stands in bold relief against distant plains, as viewed by NASA's 'Spirit' rover from the top of 'Husband Hill' on Mars. 'The view of the summit is spectacular where we are right now,' said geologist Larry Crumpler, with the New Mexico Museum of Natural History and Science, Albuquerque.

    From here, Spirit is looking north-northeast en route to examining more of the local geology of the 'Columbia Hills' in Gusev Crater. A few days after taking this picture, Spirit investigated the small, sinuous drifts on the left, located north-northeast of the rover's position in this image. The last previous time Spirit examined a drift was on the rim of 'Bonneville Crater' almost 500 martian days, or sols, ago, in March 2004.

    The largest light-colored rock in the foreground is nicknamed 'Whittaker.' The cliff beyond it and slightly to the left is nicknamed 'Tenzing.' The highest rock on the ridge ahead has been dubbed 'Hillary.' Science team members selected the nicknames in honor of the earliest climbers to scale Mount Everest on Earth. This view covers approximately 50 degrees of the compass from left to right. It is a mosaic assembled from frames Spirit took with the panoramic camera on sol 603 (Sept. 13, 2005). It was taken through a blue (430-nanometer) filter and is presented as a cylindrical projection.

  19. Sex and Gender Medical Education Summit: a roadmap for curricular innovation.

    PubMed

    Chin, Eliza L; Hoggatt, Marley; McGregor, Alyson J; Rojek, Mary K; Templeton, Kimberly; Casanova, Robert; Klein, Wendy S; Miller, Virginia M; Jenkins, Marjorie

    2016-01-01

    The Sex and Gender Medical Education Summit: a roadmap for curricular innovation was a collaborative initiative of the American Medical Women's Association, Laura W. Bush Institute for Women's Health, Mayo Clinic, and Society for Women's Health Research (www.sgbmeducationsummit.com). It was held on October 18-19, 2015 to provide a unique venue for collaboration among nationally and internationally renowned experts in developing a roadmap for the incorporation of sex and gender based concepts into medical education curricula. The Summit engaged 148 in-person attendees for the 1 1/2-day program. Pre- and post-Summit surveys assessed the impact of the Summit, and workshop discussions provided a framework for informal consensus building. Sixty-one percent of attendees indicated that the Summit had increased their awareness of the importance of sex and gender specific medicine. Other comments indicate that the Summit had a significant impact for motivating a call to action among attendees and provided resources to initiate change in curricula within their home institutions. These educational efforts will help to ensure a sex and gender basis for delivery of health care in the future.

  20. Catalog of Tephra Samples from Kilauea's Summit Eruption, March-December 2008

    USGS Publications Warehouse

    Wooten, Kelly M.; Thornber, Carl R.; Orr, Tim R.; Ellis, Jennifer F.; Trusdell, Frank A.

    2009-01-01

    The opening of a new vent within Halema'uma'u Crater in March 2008 ended a 26-year period of no eruptive activity at the summit of Kilauea Volcano. It also heralded the first explosive activity at Kilauea's summit since 1924 and the first of eight discrete explosive events in 2008. At the onset of the eruption, the Hawaiian Volcano Observatory (HVO) initiated a rigorous program of sample collection to provide a temporally constrained suite of tephra samples for petrographic, geochemical, and isotopic studies. Petrologic studies help us understand conditions of magma generation at depth; processes related to transport, storage, and mixing of magma within the shallow summit region; and specific circumstances leading to explosive eruptions. This report provides a catalog of tephra samples erupted at Kilauea's summit from March 19, 2008, through the end of 2008. The Kilauea 2008 Summit Sample Catalog is tabulated in the accompanying Microsoft Excel file, of2009-1134.xls (four file types linked on right). The worksheet in this file provides sampling information and sample descriptions. Contextual information for this catalog is provided below and includes (1) a narrative of 2008 summit eruptive activity, (2) a description of sample collection methods, (3) a scheme for characterizing a diverse range in tephra lithology, and (4) an explanation of each category of sample information (column headers) in the Microsoft Excel worksheet.

  1. Air mass trajectories to Summit, Greenland: A 44-year climatology and some episodic events

    NASA Astrophysics Data System (ADS)

    Kahl, Jonathan D. W.; Martinez, Dewayne A.; Kuhns, Hampden; Davidson, Clifford I.; Jaffrezo, Jean-Luc; Harris, Joyce M.

    1997-11-01

    The seasonal variation in atmospheric transport patterns to Summit, Greenland, is examined using a 44-year record of daily, 10-day, isobaric back trajectories at the 500-hPa level. Over 24,000 modeled trajectories are aggregated into distinct patterns using cluster analysis. Ten-day trajectories reaching Summit are longest during winter, with 67% extending upwind (westward) as far back as Asia or Europe. Trajectories are shortest during summer, with 46% having 10-day origins over North America. During all seasons a small percentage (3-7%) of trajectories originate in west Asia/Europe and follow a meridional path over the Arctic Ocean before approaching Summit from the northwest. Trajectories at the 700-hPa level tend to be shorter than at 500 hPa, with many of the 700-hPa trajectories from North America tracking over the North Atlantic and approaching Summit from the south. The long-range transport climatology for Summit is similar to a year-round climatology prepared for Dye 3, located 900 km to the south [Davidson et al., 1993b]. An analysis of several aerosol species measured at Summit during summer 1994 reveals examples of the usefulness and also the limitations of using long-range air trajectories to interpret chemical data.

  2. "A Paradox Persists When the Paradigm Is Wrong": Pisacano Scholars' Reflections from the Inaugural Starfield Summit.

    PubMed

    Doohan, Noemi; Coutinho, Anastasia J; Lochner, Jennifer; Wohler, Diana; DeVoe, Jennifer

    The inaugural Starfield Summit was hosted in April 2016 by the Robert Graham Center for Policy Studies in Family Medicine and Primary Care with additional partners and sponsors, including the Pisacano Leadership Foundation (PLF). The Summit addressed critical topics in primary care and health care delivery, including payment, measurement, and team-based care. Invited participants included an interdisciplinary group of pediatricians, family physicians, internists, behaviorists, trainees, researchers, and advocates. Among the family physicians invited were both current and past PLF (Pisacano) scholars. After the Summit, a small group of current and past Pisacano scholars formed a writing group to reflect on and summarize key lessons and conclusions from the Summit. A Summit participant's statement, "a paradox persists when the paradigm is wrong," became a repeated theme regarding the paradox of primary care within the context of the health care system in the United States. The Summit energized participants to renew their commitment to Dr. Starfield's 4 C's of Primary Care (first contact access, continuity, comprehensiveness, and care coordination) and to the Quadruple Aim (quality, value, and patient and physician satisfaction) and to continue to explore how primary care can best shape the future of the nation's health care system.

  3. MDI Biological Laboratory Arsenic Summit: Approaches to Limiting Human Exposure to Arsenic.

    PubMed

    Stanton, Bruce A; Caldwell, Kathleen; Congdon, Clare Bates; Disney, Jane; Donahue, Maria; Ferguson, Elizabeth; Flemings, Elsie; Golden, Meredith; Guerinot, Mary Lou; Highman, Jay; James, Karen; Kim, Carol; Lantz, R Clark; Marvinney, Robert G; Mayer, Greg; Miller, David; Navas-Acien, Ana; Nordstrom, D Kirk; Postema, Sonia; Rardin, Laurie; Rosen, Barry; SenGupta, Arup; Shaw, Joseph; Stanton, Elizabeth; Susca, Paul

    2015-09-01

    This report is the outcome of the meeting "Environmental and Human Health Consequences of Arsenic" held at the MDI Biological Laboratory in Salisbury Cove, Maine, August 13-15, 2014. Human exposure to arsenic represents a significant health problem worldwide that requires immediate attention according to the World Health Organization (WHO). One billion people are exposed to arsenic in food, and more than 200 million people ingest arsenic via drinking water at concentrations greater than international standards. Although the US Environmental Protection Agency (EPA) has set a limit of 10 μg/L in public water supplies and the WHO has recommended an upper limit of 10 μg/L, recent studies indicate that these limits are not protective enough. In addition, there are currently few standards for arsenic in food. Those who participated in the Summit support citizens, scientists, policymakers, industry, and educators at the local, state, national, and international levels to (1) establish science-based evidence for setting standards at the local, state, national, and global levels for arsenic in water and food; (2) work with government agencies to set regulations for arsenic in water and food, to establish and strengthen non-regulatory programs, and to strengthen collaboration among government agencies, NGOs, academia, the private sector, industry, and others; (3) develop novel and cost-effective technologies for identification and reduction of exposure to arsenic in water; (4) develop novel and cost-effective approaches to reduce arsenic exposure in juice, rice, and other relevant foods; and (5) develop an Arsenic Education Plan to guide the development of science curricula as well as community outreach and education programs that serve to inform students and consumers about arsenic exposure and engage them in well water testing and development of remediation strategies.

  4. MDI Biological Laboratory Arsenic Summit: Approaches to Limiting Human Exposure to Arsenic

    PubMed Central

    Stanton, Bruce A.

    2015-01-01

    This report is the outcome of the meeting: “Environmental and Human Health Consequences of Arsenic”, held at the MDI Biological Laboratory in Salisbury Cove, Maine, August 13–15, 2014. Human exposure to arsenic represents a significant health problem worldwide that requires immediate attention according to the World Health Organization (WHO). One billion people are exposed to arsenic in food and more than 200 million people ingest arsenic via drinking water at concentrations greater than international standards. Although the U.S. Environmental Protection Agency (EPA) has set a limit of 10 micrograms per liter (10 μg/L) in public water supplies and the WHO has recommended an upper limit of 10 μg/L, recent studies indicate that these limits are not protective enough. In addition, there are currently few standards for arsenic in food. Those who participated in the Summit support citizens, scientists, policymakers, industry and educators at the local, state, national and international levels to: (1) Establish science-based evidence for setting standards at the local, state, national, and global levels for arsenic in water and food; (2) Work with government agencies to set regulations for arsenic in water and food, to establish and strengthen non-regulatory programs, and to strengthen collaboration among government agencies, NGOs, academia, the private sector, industry and others; (3) Develop novel and cost-effective technologies for identification and reduction of exposure to arsenic in water; (4) Develop novel and cost-effective approaches to reduce arsenic exposure in juice, rice, and other relevant foods, and (5) Develop an Arsenic Education Plan to guide the development of science curricula as well as community outreach and education programs that serve to inform students and consumers about arsenic exposure and engage them in well water testing and development of remediation strategies. PMID:26231509

  5. The World Summit on Sustainable Development: reaffirming the centrality of health

    PubMed Central

    von Schirnding, Yasmin

    2005-01-01

    The World Summit on Sustainable Development (WSSD) was held in Johannesburg in 2002 to review progress since the Rio conference in 1992, and to agree a new global deal on sustainable development. Unlike its predecessor, it was primarily concerned with implementation rather than with new treaties and targets, although a number of new targets were agreed, for example one on sanitation. Failure to agree a target on renewable energy was regarded as a major disappointment of the conference. While relatively modest in its achievements, and with difficulties in achieving consensus in key areas such as energy, trade, finance and globalisation, WSSD nevertheless succeeded in placing sustainable development back on the political agenda, giving new impetus, in particular to the environment and development needs of Africa, with a strong focus on local issues like household energy, water and sanitation. Health was singled out as one of five priority areas, along with water, energy, agriculture and biodiversity, and was devoted a separate chapter in the resulting Plan of Implementation, which highlighted a range of environmental health issues as well as issues relating to health services, communicable and non-communicable diseases. A number of new partnerships were formed at WSSD, including the Healthy Environments for Children Alliance (HECA) launched by WHO, which will form an important platform for implementation. The Commission on Sustainable Development has been designated main responsibility for monitoring and follow up, with its programme of work reorganised to focus on thematic clusters of issues. From the perspective of health, WSSD must be seen as a reaffirmation of the central place of health on the sustainable development agenda, and in the broader context of a process which began in Rio and was given added impetus with the Monterrey Financing for Development conference and the World Trade Organisation meeting held in Doha. Translating policies into action at all

  6. Kīlauea summit eruption—Lava returns to Halemaʻumaʻu

    USGS Publications Warehouse

    Babb, Janet L.; Wessells, Stephen M.; Neal, Christina A.

    2017-10-06

    In March 2008, a new volcanic vent opened within Halemaʻumaʻu, a crater at the summit of Kīlauea Volcano in Hawaiʻi Volcanoes National Park on the Island of Hawaiʻi. This new vent is one of two ongoing eruptions on the volcano. The other is on Kīlauea’s East Rift Zone, where vents have been erupting nearly nonstop since 1983. The duration of these simultaneous summit and rift zone eruptions on Kīlauea is unmatched in at least 200 years.Since 2008, Kīlauea’s summit eruption has consisted of continuous degassing, occasional explosive events, and an active, circulating lava lake. Because of ongoing volcanic hazards associated with the summit vent, including the emission of high levels of sulfur dioxide gas and fragments of hot lava and rock explosively hurled onto the crater rim, the area around Halemaʻumaʻu remains closed to the public as of 2017.Through historical photos of past Halemaʻumaʻu eruptions and stunning 4K imagery of the current eruption, this 24-minute program tells the story of Kīlauea Volcano’s summit lava lake—now one of the two largest lava lakes in the world. It begins with a Hawaiian chant that expresses traditional observations of a bubbling lava lake and reflects the connections between science and culture that continue on Kīlauea today.The video briefly recounts the eruptive history of Halemaʻumaʻu and describes the formation and continued growth of the current summit vent and lava lake. It features USGS Hawaiian Volcano Observatory scientists sharing their insights on the summit eruption—how they monitor the lava lake, how and why the lake level rises and falls, why explosive events occur, the connection between Kīlauea’s ongoing summit and East Rift Zone eruptions, and the impacts of the summit eruption on the Island of Hawaiʻi and beyond. The video is also available at the following U.S. Geological Survey Multimedia Gallery link (video hosted on YouTube): Kīlauea summit eruption—Lava returns to Halemaʻumaʻu

  7. Summit on the National Effort To Prevent Mental Retardation and Related Disabilities. Summit Proceedings (Washington, D.C., February 6-7, 1991).

    ERIC Educational Resources Information Center

    President's Committee on Mental Retardation, Washington, DC.

    This document reports the proceedings of a summit to assess the adequacy of the U.S. effort to prevent mental retardation and related disabilities and to chart the course for future strategies to reduce the incidence and ameliorate the effects of these disabilities, particularly when caused by socioeconomic conditions. The document contains…

  8. Assessment and monitoring of recreation impacts and resource conditions on mountain summits: examples from the Northern Forest, USA

    USGS Publications Warehouse

    Monz, Christopher A.; Marion, Jeffrey L.; Goonan, Kelly A.; Manning, Robert E.; Wimpey, Jeremy; Carr, Christopher

    2010-01-01

    Mountain summits present a unique challenge to manage sustainably: they are ecologically important and, in many circumstances, under high demand for recreation and tourism activities. This article presents recent advances in the assessment of resource conditions and visitor disturbance in mountain summit environments, by drawing on examples from a multiyear, interdisciplinary study of summits in the northeastern United States. Primary impact issues as a consequence of visitor use, such as informal trail formation, vegetation disturbance, and soil loss, were addressed via the adaption of protocols from recreation ecology studies to summit environments. In addition, new methodologies were developed that provide measurement sensitivity to change previously unavailable through standard recreation monitoring protocols. Although currently limited in application to the northeastern US summit environments, the methods presented show promise for widespread application wherever summits are in demand for visitor activities.

  9. Geology of the Cerro Summit quadrangle, Montrose County, Colorado

    USGS Publications Warehouse

    Dickinson, Robert G.

    1966-01-01

    The Cerro Summit quadrangle covers 58 square miles of dissected plateau on the south flank of the Gunnison uplift in southwestern Colorado. It lies east of the Uncompahgre River valley and south of the Black Canyon of the Gunnison River. Rocks dip gently in most of the quadrangle, but they are locally upturned and faulted on the margin of the Gunnison uplift and are intensely deformed in the core of the uplift. The rocks exposed are of Precambrian, late Mesozoic, and Cenozoic age. Precambrian rocks include metasedimentary schist and gneiss, granitic pegmatite, and olivine gabbro. The oldest Mesozoic rocks exposed are continental, fresh-water, and lagoonal deposits in the Late Jurassic Entrada Sandstone, Wanakah Formation, and Morrison Formation. Channel-fill deposits that unconformably overlie the Jurassic rocks are possibly the Burro Canyon Formation of Early Cretaceous age. Upper Cretaceous rocks include marine and nearshore deposits of the Dakota Sandstone, Mancos Shale, and Pictured Cliffs Sandstone, and the fresh- and brackish-water sandstone, shale, and coal of the Fruitland Formation. Rocks of Late Cretaceous age that crop out in the adjacent Cimarron Ridge area may also have been deposited in this quadrangle but are now eroded; these rocks include the nonmarine Kirtland Shale and an unnamed volcanic conglomerate and tuff breccia. Nine faunal zones in the Mancos Shale help to establish the correct correlation of units in the Upper Cretaceous. The Pictured Cliffs Sandstone, Fruitland Formation, and Kirtland Shale of the Cerro Summit area have been mapped by some geologists as the Mesaverde Formation. Fossils indicate that the rocks are younger than the type Mesaverde. The unnamed volcanic rocks represent major volcanism in nearby areas. A Late Cretaceous (Maestrichtian) age for the volcanism is indicated by palynological evidence and an isotopic age of approximately 66 million years. Middle Tertiary rocks are conglomerate and tuff breccia. Upper Tertiary or

  10. Interannual Variations of Shallow Firn Temperature at Greenland Summit

    NASA Technical Reports Server (NTRS)

    Jun, Li; Wang, W. L.; Zwally, H. J.; Koblinsky, Chester J. (Technical Monitor)

    2001-01-01

    Firn-temperature profiles are calculated in a thermal model using continuous surface temperatures derived from Automatic Weather Station (AWS) data and passive microwave data in the Greenland Summit region during the period 1987-1999. The results show that significant interannual variations of mean summer (June to August) and annual temperatures occur in the top 15 m, in addition to the normal seasonal cycle of firn temperature. At 5 m depth, the seasonal cycle is damped to 13% of the surface seasonal amplitude, but even at 15 m about 1% or 0.6 C of the seasonal cycle persists. Both summer and mean annual temperatures decrease from 1987 to 1992, followed by a general increasing trend. Interannual variability is 5 C at the surface, but only is only dampened to 3.2 C at 10 m depth and 0.7 C at 15 m depth. Dampening of the interannual variability with depth is slower than dampening of the seasonal cycle, because of the longer time constant of the interannual variation. The warmer spring and summer temperatures experienced in the top 5 m, due to both the seasonal cycle and interannual variations, affect the rate of firn densification, which is non-linearly dependent on temperature. During the 12 year period 1987-1999, the mean annual surface temperature is -29.2 C, and the mean annual 15 m temperature is -30. 1 C, which is more than 1 C warmer than a 15-m borehole temperature representing the period of about 1959 and warmer than the best-fit temperature history by Alley and Koci back to 1500 A.D..

  11. Descent from the Summit of 'Husband Hill' (False Color)

    NASA Technical Reports Server (NTRS)

    2005-01-01

    In late November 2005 while descending 'Husband Hill,' NASA's Mars Exploration Rover Spirit took the most detailed panorama so far of the 'Inner Basin,' the rover's next target destination. Spirit acquired the 405 individual images that make up this 360-degree view of the surrounding terrain using five different filters on the panoramic camera. The rover took the images on Martian days, or sols, 672 to 677 (Nov. 23 to 28, 2005 -- the Thanksgiving holiday weekend).

    This image is a false-color rendering using camera's 750-, 530-, and 430-nanometer filters, emphasizing some colors more than others to enhance striking but subtle color differences among rocks, soils, hills, and plains.

    'Home Plate,' a bright, semi-circular feature scientists hope to investigate, is harder to discern in this image than in earlier views taken from higher up the hill. Spirit acquired this more oblique view, known as the 'Seminole panorama,' from about halfway down the south flank of Husband Hill, 50 meters (164 feet) or so below the summit. Near the center of the panorama, on the horizon, are 'McCool Hill' and 'Ramon Hill,' named, like Husband Hill, in honor of the fallen astronauts of the space shuttle Columbia. Husband Hill is visible behind the rover, on the right and left sides of the panorama. An arc of rover tracks made while avoiding obstacles and getting into position to examine rock outcrops can be traced over a long distance by zooming in to explore the panorama in greater detail.

    Spirit is now significantly farther downhill toward the center of this panorama, en route to Home Plate and other enigmatic soils and outcrop rocks in the quest to uncover the history of Gusev Crater and the 'Columbia Hills.'

  12. Descent from the Summit of 'Husband Hill' (False Color)

    NASA Technical Reports Server (NTRS)

    2005-01-01

    In late November 2005 while descending 'Husband Hill,' NASA's Mars Exploration Rover Spirit took the most detailed panorama so far of the 'Inner Basin,' the rover's next target destination. Spirit acquired the 405 individual images that make up this 360-degree view of the surrounding terrain using five different filters on the panoramic camera. The rover took the images on Martian days, or sols, 672 to 677 (Nov. 23 to 28, 2005 -- the Thanksgiving holiday weekend).

    This image is a false-color rendering using camera's 750-, 530-, and 430-nanometer filters, emphasizing some colors more than others to enhance striking but subtle color differences among rocks, soils, hills, and plains.

    'Home Plate,' a bright, semi-circular feature scientists hope to investigate, is harder to discern in this image than in earlier views taken from higher up the hill. Spirit acquired this more oblique view, known as the 'Seminole panorama,' from about halfway down the south flank of Husband Hill, 50 meters (164 feet) or so below the summit. Near the center of the panorama, on the horizon, are 'McCool Hill' and 'Ramon Hill,' named, like Husband Hill, in honor of the fallen astronauts of the space shuttle Columbia. Husband Hill is visible behind the rover, on the right and left sides of the panorama. An arc of rover tracks made while avoiding obstacles and getting into position to examine rock outcrops can be traced over a long distance by zooming in to explore the panorama in greater detail.

    Spirit is now significantly farther downhill toward the center of this panorama, en route to Home Plate and other enigmatic soils and outcrop rocks in the quest to uncover the history of Gusev Crater and the 'Columbia Hills.'

  13. A re-investigation of the ribonuclease sensitivity of a DNA demethylation reaction in chicken embryo and G8 mouse myoblasts.

    PubMed

    Jost, J P; Siegmann, M; Thiry, S; Jost, Y C; Benjamin, D; Schwarz, S

    1999-04-23

    Recently published results (Nucleic Acids Res. 26, 5573-5580, 1998) suggest that the ribonuclease sensitivity of the DNA demethylation reaction may be an experimental artifact due to the possible tight binding of the nucleases to the methylated DNA substrate. Using an improved protocol we show for two different systems that demethylation of hemimethylated DNA is indeed sensitive to micrococcal nuclease, requires RNA and is not an experimental artifact. The purified 5-MeC-DNA glycosylase from chicken embryos and G8 mouse myoblasts was first incubated for 5 min at 37 degrees C with micrococcal nuclease in the presence of Ca2+ in the absence of the DNA substrate. Upon blocking the nuclease activity by the addition of 25 mM EGTA, the DNA demethylation reaction was initiated by adding the labeled hemimethylated DNA substrate to the reaction mixture. Under these conditions the DNA demethylation reaction was abolished. In parallel controls, where the purified 5-MeC-DNA glycosylase was pre-incubated at 37 degrees C with the nuclease, Ca2+ and EGTA or with the nuclease and EGTA, RNA was not degraded and no inhibition of the demethylation reaction was obtained. As has already been shown for chicken embryos, the loss of 5-MeC-DNA glycosylase activity from G8 myoblasts following nuclease treatment can also be restored by the addition of synthetic RNA complementary to the methylated strand of the substrate DNA. No reactivation of 5-MeC-DNA glycosylase is obtained by complementation with a random RNA sequence, the RNA sequence complementary to the non-methylated strand or DNA, thus ruling out a non-specific competition of the RNA for the binding of the nuclease to the labeled DNA substrate.

  14. Proceedings of the November 2011 Traceability Research Summit: this report is the third in a series on Traceability Summits sponsored by IFT beginning in July 2011.

    PubMed

    Hickey, Caitlin; Bhatt, Tejas

    2013-12-01

    Fifty thought leaders in the area of food traceability met for a 3rd time to discuss methodologies and finalize the principles that define their vision for traceability. Participants in the summit included representatives from industry, trade associations, government, academia, consumer groups, and more. One main focus of this summit included a discussion on the current regulations and voluntary initiatives in place regarding traceability. Overall, it was recognized that the recommendations from this summit group would be more specific and stringent in comparison to these current regulations and initiatives. The participants sought to be leaders in the traceability arena, with their recommendations leading the industry to optimal traceability systems and methods. Participants agreed on many principles for their vision of traceability, emphasizing the importance of access to traceability data. They discussed having industry be asked for "basic" tracing data prior to the need for a large-scale investigation, having standards for sharing data, and having the data in electronic form. Participants foresaw the importance of capturing data electronically in the future, although they recognized that many firms do not currently do this. The group also saw a need for a transition period to implement changes, and to provide implementation training and resource aid to small businesses. Summit participants discussed specific definitions and examples for key data elements and critical tracking events that could be used by industry to capture tracing data at specific points within the supply chain. Overall, participants refined the goals of the summit group and started to identify specific ways to achieve those goals.

  15. Circumarctic Conversations: Using Strategic Communication to Engage Participants and the Community in the 2016 Arctic Science Summit Week

    NASA Astrophysics Data System (ADS)

    Mitchell, S.; Timm, K.; Bakker, T.

    2016-12-01

    Arctic Science Summit Week (ASSW) is the annual gathering of international organizations engaged in supporting and facilitating Arctic research. The University of Alaska Fairbanks hosted the 2016 ASSW and several associated side meetings that attracted over 1,000 participants from 30 nations. Unlike most scientific conferences, a strategic communication plan was developed to engage key audiences and stakeholder groups to achieve the goals of (1) advancing stakeholder collaboration in the Arctic and (2) increasing awareness of America's role in international collaboration in the Arctic. Beyond ensuring that the conference was well attended and participants had the information to have a successful meeting, the communication plan also included several objectives to engage the broader community in opportunities to benefit from subject area experts attending the conference and learn about Arctic science. The strategic communication effort was instrumental in the success of the conference and several community events. However, introducing strategic communication into a process and to people with no prior experience also added some challenges. In order to be successful, we had to develop a shared understanding of the strategic communication process and discipline-specific terms with our colleagues in the biophysical sciences. The outcomes and lessons that will be shared in this poster are valuable to anyone in science or environmental communication, planning conference communications, and/or those who are adopting strategic communication approaches where they haven't previously existed.

  16. The meta-leadership summit for preparedness initiative: an innovative model to advance public health preparedness and response.

    PubMed

    Sobelson, Robyn K; Young, Andrea C; Marcus, Leonard J; Dorn, Barry C; Neslund, Verla S; McNulty, Eric J

    2013-12-01

    This article reports on the design, evaluation framework, and results from the Meta-Leadership Summit for Preparedness Initiative. The Meta-Leadership Summit for Preparedness was a 5-year initiative based on the premise that national preparedness and emergency response is not solely the responsibility of government. From 2006 to 2011, 36 Meta-Leadership Summits were delivered in communities across the country. Summits were customized, 10-hour leadership development, networking, and community action planning events. They included participation from targeted federal, state, local, nonprofit/philanthropic, and private sector leaders who are directly involved in decision making during a major community or state-wide emergency. A total of 4,971 government, nonprofit, and business leaders attended Meta-Leadership Summits; distribution of attendees by sector was balanced. Ninety-three percent of respondents reported the summit was a valuable use of time, 91% reported the overall quality as "good" or "outstanding," and 91% would recommend the summit to their colleagues. In addition, approximately 6 months after attending a summit, 80% of respondents reported that they had used meta-leadership concepts or principles. Of these, 93% reported that using meta-leadership concepts or principles had made a positive difference for them and their organizations. The Meta-Leadership Summit for Preparedness Initiative was a value-added opportunity for communities, providing the venue for learning the concepts and practice of meta-leadership, multisector collaboration, and resource sharing with the intent of substantively improving preparedness, response, and recovery efforts.

  17. Development and evaluation of a regional, large-scale interprofessional collaborative care summit.

    PubMed

    Foote, Edward F; Clarke, Virginia; Szarek, John L; Waters, Sharon K; Walline, Vera; Shea, Diane; Goss, Sheryl; Farrell, Marian; Easton, Diana; Dunleavy, Erin; Arscott, Karen

    2015-01-01

    The Northeastern/Central Pennsylvania Interprofessional Education Coalition (NECPA IPEC) is a coalition of faculty from multiple smaller academic institutions with a mission to promote interprofessional education. An interprofessional learning program was organized, which involved 676 learners from 10 different institutions representing 16 unique professions, and took place at seven different institutions simultaneously. The program was a 3-hour long summit which focused on the management of a patient with ischemic stroke. A questionnaire consisting of the Interprofessional Education Perception Scale (IEPS) questionnaire (pre-post summit), Likert-type questions, and open comment questions explored the learners' perceptions of the session and their attitudes toward interprofessional learning. Responses were analyzed using descriptive statistics and statistical tests for difference and qualitative thematic coding. The attitude of learners toward interprofessional education (as measured by the IEPS) was quite high even prior to the summit, so there were no significant changes after the summit. However, a high percentage of learners and facilitators agreed that the summit met its objective and was effective. In addition, the thematic analysis of the open-ended questions confirmed that students learned from the experience with a sense of the core competencies of interprofessional education and practice. A collaborative approach to delivering interprofessional learning is time and work intensive but beneficial to learners.

  18. Third International Summit: Current status of sleeve gastrectomy.

    PubMed

    Deitel, Mervyn; Gagner, Michel; Erickson, Ann L; Crosby, Ross D

    2011-01-01

    Laparoscopic sleeve gastrectomy (LSG) has been performed for morbid obesity in the past 10 years. LSG was originally intended as a first-stage procedure in high-risk patients but has become a stand-alone operation for many bariatric surgeons. Ongoing review is necessary regarding the durability of the weight loss, complications, and need for second-stage operations. The first International Summit for LSG was held in October 2007, the second in March 2009, and this third in December 2010. There were presentations by experts, and, to provide a consensus, a questionnaire was completed by 88 attendees who had >1 year (mean 3.6 ± 1.5, range 1-8) of experience with LSG. The results of the questionnaire were based on 19,605 LSGs performed within 3.6 ± 1.5 years (228.8 ± 275.0 LSGs/surgeon). LSG had been intended as the sole operation in 86.4% of the cases; in these, a second-second stage became necessary in 2.2%. LSG was completed laparoscopically in 99.7% of the cases. The mean percentage of excess weight loss at 1, 2, 3, 4, and 5 years was 62.7%, 64.7%, 64.0%, 57.3%, and 60.0%, respectively. The bougie size was 28-60F (mean 36F, 70% blunt tip). Resection began 1.5-7.0 cm (mean 4.8) proximal to the pylorus. Of the surgeons, 67.1% reinforced the staple line, 57% with buttress material and 43% with oversewing. The respondents excised an estimated 92.9% ± 8.0% (median 95.0%) of fundus (i.e., a tiny portion is maintained lateral to the angle of His). A drain is left by 57.6%, usually closed suction. High leaks occurred in 1.3% of cases (range 0-10%); lower leaks occurred in .5%. Intraluminal bleeding occurred in 2.0% of cases. The mortality rate was .1% ± .3%. According to the questionnaire, presentations, and debates, the weight loss and improvement in diabetes appear to be better than with laparoscopic adjustable gastric banding and on par with Roux-en-Y gastric bypass. High leaks are infrequent but problematic. Copyright © 2011 American Society for Metabolic and

  19. 2012 ARPA-E Energy Innovation Summit: Profiling General Compression: A River of Wind

    ScienceCinema

    Marcus, David; Ingersoll, Eric

    2016-07-12

    The third annual ARPA-E Energy Innovation Summit was held in Washington D.C. in February, 2012. The event brought together key players from across the energy ecosystem - researchers, entrepreneurs, investors, corporate executives, and government officials - to share ideas for developing and deploying the next generation of energy technologies. A few videos were selected for showing during the Summit to attendees. These 'performer videos' highlight innovative research that is ongoing and related to the main topics of the Summit's sessions. Featured in this video are David Marcus, Founder of General Compression, and Eric Ingersoll, CEO of General Compression. General Compression, with the help of ARPA-E funding, has created an advanced air compression process which can store and release more than a weeks worth of the energy generated by wind turbines.

  20. 2012 ARPA-E Energy Innovation Summit: Profiling General Compression: A River of Wind

    SciTech Connect

    Marcus, David; Ingersoll, Eric

    2012-02-29

    The third annual ARPA-E Energy Innovation Summit was held in Washington D.C. in February, 2012. The event brought together key players from across the energy ecosystem - researchers, entrepreneurs, investors, corporate executives, and government officials - to share ideas for developing and deploying the next generation of energy technologies. A few videos were selected for showing during the Summit to attendees. These 'performer videos' highlight innovative research that is ongoing and related to the main topics of the Summit's sessions. Featured in this video are David Marcus, Founder of General Compression, and Eric Ingersoll, CEO of General Compression. General Compression, with the help of ARPA-E funding, has created an advanced air compression process which can store and release more than a weeks worth of the energy generated by wind turbines.

  1. Recommendations from the 2008 International Summit on Proteomics Data Release and Sharing Policy: the Amsterdam principles.

    PubMed

    Rodriguez, Henry; Snyder, Mike; Uhlén, Mathias; Andrews, Phil; Beavis, Ronald; Borchers, Christoph; Chalkley, Robert J; Cho, Sang Yun; Cottingham, Katie; Dunn, Michael; Dylag, Tomasz; Edgar, Ron; Hare, Peter; Heck, Albert J R; Hirsch, Roland F; Kennedy, Karen; Kolar, Patrik; Kraus, Hans-Joachim; Mallick, Parag; Nesvizhskii, Alexey; Ping, Peipei; Pontén, Fredrik; Yang, Liming; Yates, John R; Stein, Stephen E; Hermjakob, Henning; Kinsinger, Christopher R; Apweiler, Rolf

    2009-07-01

    Policies supporting the rapid and open sharing of genomic data have directly fueled the accelerated pace of discovery in large-scale genomics research. The proteomics community is starting to implement analogous policies and infrastructure for making large-scale proteomics data widely available on a precompetitive basis. On August 14, 2008, the National Cancer Institute (NCI) convened the "International Summit on Proteomics Data Release and Sharing Policy" in Amsterdam, The Netherlands, to identify and address potential roadblocks to rapid and open access to data. The six principles agreed upon by key stakeholders at the summit addressed issues surrounding (1) timing, (2) comprehensiveness, (3) format, (4) deposition to repositories, (5) quality metrics, and (6) responsibility for proteomics data release. This summit report explores various approaches to develop a framework of data release and sharing principles that will most effectively fulfill the needs of the funding agencies and the research community.

  2. The "Ethics Rupture" Summit, Fredericton, New Brunswick, Canada, October 25-28, 2012.

    PubMed

    van den Hoonaard, Will C

    2013-02-01

    This report explains the background of the "Ethics Rupture" Summit held in New Brunswick, Canada, October 2012, focusing on the disconnect between research-ethics policies and the nature and purpose of social-science research-an unintended "rupture" in ethics governance. Ethics is about human relationships, and the governance of ethics must reflect that fact rather than function as a bureaucratic, self-legitimating system of control. The themes that emerged from the Summit point to: structural problems with the current system; an undermining of the original, historical mission of some social-science disciplines; a discomfort with new methodologies; ethics committees and the well-being and education of social-science students; the possibilities of reform and renewal; and the next steps. Finally, the report refers in broad outlines to a "New Brunswick Declaration," which is currently being considered by participants of the Summit.

  3. Monitoring the December 2015 summit eruptions of Mt. Etna (Italy): Implications on eruptive dynamics

    NASA Astrophysics Data System (ADS)

    Corsaro, R. A.; Andronico, D.; Behncke, B.; Branca, S.; Caltabiano, T.; Ciancitto, F.; Cristaldi, A.; De Beni, E.; La Spina, A.; Lodato, L.; Miraglia, L.; Neri, M.; Salerno, G.; Scollo, S.; Spata, G.

    2017-07-01

    A lengthy period of eruptive activity from the summit craters of Mt. Etna started in January 2011. It culminated in early December 2015 with a spectacular sequence of intense eruptive events involving all four summit craters (Voragine, Bocca Nuova, New Southeast Crater, and Northeast Crater). The activity consisted of high eruption columns, Strombolian explosions, lava flows and widespread ash falls that repeatedly interfered with air traffic. The most powerful episode occurred on 3 December 2015 from the Voragine. After three further potent episodes from the Voragine, activity shifted to the New Southeast Crater on 6 December 2015, where Strombolian activity and lava flow emission lasted for two days and were fed by the most primitive magma of the study period. Activity once more shifted to the Northeast Crater, where ash emission and weak Strombolian activity took place for several days. Sporadic ash emissions from all craters continued until 18 December, when all activity ceased. Although resembling the summit eruptions of 1998-1999, which also involved all four summit craters, this multifaceted eruptive sequence occurred in an exceptionally short time window of less than three days, unprecedented in the recent activity of Mt. Etna. It also produced important morphostructural changes of the summit area with the coalescence of Voragine and Bocca Nuova in a single large crater, the ;Central Crater;, reproducing the morphological setting of the summit cone before the formation of Bocca Nuova in 1968. The December 2015 volcanic crisis was followed closely by the staff of the Etna Observatory to monitor the on-going activity and forecast its evolution, in accordance with protocols agreed with the Italian Civil Protection Department.

  4. Kilauea summit overflows: Their ages and distribution in the Puna District, Hawai'i

    USGS Publications Warehouse

    Clague, D.A.; Hagstrum, J.T.; Beeson, M.H.; Champion, D.E.

    1999-01-01

    The tube-fed pahoehoe lava flows covering much of the northeast flank of Kilauea Volcano are named the 'Aila'au flows. Their eruption age, based on published and six new radiocarbon dates, is approximately AD 1445. The flows have distinctive paleomagnetic directions with steep inclinations (40??-50??) and easterly declinations (0??-10??E). The lava was transported ~40 km from the vent to the coast in long, large-diameter lava tubes; the longest tube (Kazumura Cave) reaches from near the summit to within several kilometers of the coast near Kaloli Point. The estimated volume of the 'Aila'au flow field is 5.2 ?? 0.8 km3, and the eruption that formed it probably lasted for approximately 50 years. Summit overflows from Kilauea may have been nearly continuous between approximately AD 1290 and 1470, during which time a series of shields formed at and around the summit. The 'Aila'au shield was either the youngest or the next to youngest in this series of shields. Site-mean paleomagnetic directions for lava flows underlying the 'Aila'au flows form only six groups. These older pahoehoe flows range in age from 2750 to 2200 years. Lava flows from most of these summit eruptions also reached the coast, but none appears as extensive as the 'Aila'au flow field. The chemistry of the melts erupted during each of these summit overflow events is remarkably similar, averaging approximately 6.3 wt.% MgO near the coast and 6.8 wt.% MgO near the summit. The present-day caldera probably formed more recently than the eruption that formed the 'Aila'au flows (estimated termination ca. AD 1470). The earliest explosive eruptions that formed the Keanakako'i Ash, which is stratigraphically above the 'Aila'au flows, cannot be older than this age.

  5. Massage Therapy and Canadians’ Health Care Needs 2020: Proceedings of a National Research Priority Setting Summit

    PubMed Central

    Dryden, Trish; Sumpton, Bryn; Shipwright, Stacey; Kahn, Janet; Reece, Barbara (Findlay)

    2014-01-01

    Background The health care landscape in Canada is changing rapidly as forces, such as an aging population, increasingly complex health issues and treatments, and economic pressure to reduce health care costs, bear down on the system. A cohesive national research agenda for massage therapy (MT) is needed in order to ensure maximum benefit is derived from research on treatment, health care policy, and cost effectiveness. Setting A one-day invitational summit was held in Toronto, Ontario to build strategic alliances among Canadian and international researchers, policy makers, and other stakeholders to help shape a national research agenda for MT. Method Using a modified Delphi method, the summit organizers conducted two pre-summit surveys to ensure that time spent during the summit was relevant and productive. The summit was facilitated using the principles of Appreciative Inquiry which included a “4D” strategic planning approach (defining, discovery, dreaming, designing) and application of a SOAR framework (strengths, opportunities, aspirations, and results). Participants Twenty-six researchers, policymakers, and other stakeholders actively participated in the events. Results Priority topics that massage therapists believe are important to the Canadian public, other health care providers, and policy makers and massage therapists themselves were identified. A framework for a national massage therapy (MT) research agenda, a grand vision of the future for MT research, and a 12-month action plan were developed. Conclusion The summit provided an excellent opportunity for key stakeholders to come together and use their experience and knowledge of MT to develop a much-needed plan for moving the MT research and professionalization agenda forward. PMID:24592299

  6. Database for the Geologic Map of the Summit Region of Kilauea Volcano, Hawaii

    USGS Publications Warehouse

    Dutton, Dillon R.; Ramsey, David W.; Bruggman, Peggy E.; Felger, Tracey J.; Lougee, Ellen; Margriter, Sandy; Showalter, Patrick; Neal, Christina A.; Lockwood, John P.

    2007-01-01

    INTRODUCTION The area covered by this map includes parts of four U.S. Geological Survey (USGS) 7.5' topographic quadrangles (Kilauea Crater, Volcano, Ka`u Desert, and Makaopuhi). It encompasses the summit, upper rift zones, and Koa`e Fault System of Kilauea Volcano and a part of the adjacent, southeast flank of Mauna Loa Volcano. The map is dominated by products of eruptions from Kilauea Volcano, the southernmost of the five volcanoes on the Island of Hawai`i and one of the world's most active volcanoes. At its summit (1,243 m) is Kilauea Crater, a 3 km-by-5 km collapse caldera that formed, possibly over several centuries, between about 200 and 500 years ago. Radiating away from the summit caldera are two linear zones of intrusion and eruption, the east and the southwest rift zones. Repeated subaerial eruptions from the summit and rift zones have built a gently sloping, elongate shield volcano covering approximately 1,500 km2. Much of the volcano lies under water: the east rift zone extends 110 km from the summit to a depth of more than 5,000 m below sea level; whereas, the southwest rift zone has a more limited submarine continuation. South of the summit caldera, mostly north-facing normal faults and open fractures of the Koa`e Fault System extend between the two rift zones. The Koa`e Fault System is interpreted as a tear-away structure that accommodates southward movement of Kilauea's flank in response to distension of the volcano perpendicular to the rift zones. This digital release contains all the information used to produce the geologic map published as USGS Geologic Investigations Series I-2759 (Neal and Lockwood, 2003). The main component of this digital release is a geologic map database prepared using ArcInfo GIS. This release also contains printable files for the geologic map and accompanying descriptive pamphlet from I-2759.

  7. The crystal structure of the spinach plastocyanin double mutant G8D/L12E gives insight into its low reactivity towards photosystem 1 and cytochrome f.

    PubMed

    Jansson, Hanna; Okvist, Mats; Jacobson, Frida; Ejdebäck, Mikael; Hansson, Orjan; Sjölin, Lennart

    2003-12-08

    Plastocyanin (Pc) is a copper-containing protein, which functions as an electron carrier between the cytochrome b(6)f and photosystem 1 (PS1) complexes in the photosynthetic electron transfer (ET) chain. The ET is mediated by His87 situated in the hydrophobic surface in the north region of Pc. Also situated in this region is Leu12, which mutated to other amino acids severely disturbs the ET from cytochrome f and to PS1, indicating the importance of the hydrophobic surface. The crystal structure of the Pc double mutant G8D/L12E has been determined to 2.0 A resolution, with a crystallographic R-factor of 18.3% (R(free)=23.2%). A comparison with the wild-type structure reveals that structural differences are limited to the sites of the mutations. In particular, there is a small but significant change in the hydrophobic surface close to His87. Evidently, this leads to a mismatch in the reactive complex with the redox partners. For PS1 this results in a 20 times weaker binding and an eightfold slower ET as determined by kinetic measurements. The mutations that have been introduced do not affect the optical absorption spectrum. However, there is a small change in the EPR spectrum, which can be related to changes in the copper coordination geometry.

  8. Evaluation of the Tosoh G8 Analyzer and Comparison with the Trinity Biotech Premier Hb9210 Analyzer for the Measurement of HbA₁c.

    PubMed

    Ucar, Fatma; Erden, Gonul; Ozdemir, Seyda; Yildiz, Zeynep; Arzuhal, Abdullah Ercan; Temel, Ismail

    2016-01-01

    The aim of our study was to assess the analytical performance of the Tosoh HLC-723G8 automated analyzer and to compare it with the Trinity Biotech Premier Hb9210 analyzer for the measurement of hemoglobin A₁c (HbA₁c). A total of 101 patients with pre-diabetes or diabetes mellitus were included in the study. HbA₁c, was measured by both an ion-exchange high-performance liquid chromatography (IE-HPLC) method and a boronate affinity chromatography method. Statistical analysis was performed using Deming regression. Bland-Altman plots were used to calculate mean difference (bias). The CV% values of IE-HPLC and boronate affinity methods for within run and between days were lower than 2.0%. High correlation was found (y = 1.0045x + 0.2111; r = 0.9941) between the two methods. The method shows no interference from carbamylated hemoglobin. Both systems showed acceptable performance and are suitable for clinical application in the analysis of HbA₁c. However, laboratories should be aware of the limitations of their methods and the availability of more accurate and precise HbA₁c, determination methods.

  9. Thinking critically about whole-grain definitions: summary report of an interdisciplinary roundtable discussion at the 2015 Whole Grains Summit.

    PubMed

    Korczak, Renee; Marquart, Len; Slavin, Joanne L; Ringling, Keagan; Chu, YiFang; O'Shea, Marianne; Harriman, Cynthia; Toups, Kelly; de Vries, Jan; Jacques, Paul; Klurfeld, David M; Camire, Mary Ellen; Unnevehr, Laurian

    2016-12-01

    Definitions for whole grain (WG) have been published by governments, the food industry, and grain organizations and generally fall into 2 categories: WG and WG food. WG definitions focus on the principal components of the WGs and their proportions, whereas WG-food definitions describe the quantity of WGs present in food. In the United States, widespread agreement exists on the main parts of a definition for a WG, with a definition for a WG food still in its early stages; a standard definition that has been universally accepted does not exist. Furthermore, nutrition policy advises consumers to eat WGs for at least one-half of their total grain intake (2010 and 2015 Dietary Guidelines for Americans), but confusion exists over which foods are considered WGs and how much is needed to achieve health benefits. In December 2014, a workshop sponsored by the subcommittee on collaborative process of the US Government's Interagency Committee on Human Nutrition Research convened in Washington, DC, and recognized WG definitions as a key nutrition and public health-related issue that could benefit from further collaboration. As a follow-up to that meeting, an interdisciplinary roundtable meeting was organized at the Whole Grains Summit on 25 June 2015 in Portland, Oregon, to help resolve the issue. This article summarizes the main opportunities and challenges that were identified during the meeting for defining WGs and WG foods internationally. Definitions of WGs and WG foods that are uniformly adopted by research, food industry, consumer, and public health communities are needed to enable comparison of research results across populations.

  10. Preliminary investigation of gold mineralization in the Pedro Dome-Cleary Summit area, Fairbanks district, Alaska

    USGS Publications Warehouse

    Pilkington, H.D.; Forbes, R.B.; Hawkins, D.B.; Chapman, R.M.; Swainbank, R.C.

    1969-01-01

    Anomalous gold values in mineralized veins and hydrothermally altered quartz-mica schist in the Pedro Dome-Cleary Summit area of the Fairbanks district suggest the presence of numerous small low- to high-grade lodes. Anomalous concentrations of gold were found to exist in the wall rocks adjacent to mineralized veins. In general, the gold concentration gradients in these wall rocks are much too steep to increase appreciably the mineable width of the veins. Anomalous gold values were also detected in bedrock samples taken by means of a power auger on the Murphy Dome Road along the southwest extension of the Pedro Dome-Cleary Summit mineralized belt.

  11. An introduction to the 2011 National Multicultural Conference & Summit keynote addresses.

    PubMed

    Sánchez, Francisco J; Kawahara, Debra; Thomas, Lisa Rey; Worthington, Roger

    2011-07-01

    This article provides and introduction to the 2011 National Multicultural Conference & Summit Keynote Addresses. The authors explain that they chose to focus on the tension and possibilities within multicultural psychology at the seventh biennial National Multicultural Conference & Summit (NMCS), which was held on January 27-28, 2011, at The Westin-Seattle Hotel. During the 2-day conference, nearly 900 attendees engaged with one another and heard from experts in the field as we focused on the theme, "Unification through Diversity: Bridging Psychological Science & Practice in the Public Interest. Two key sets of presentations are highlighted.

  12. Participants in the First Florida Summit at the KSC Visitor Complex.

    NASA Technical Reports Server (NTRS)

    2000-01-01

    Before the start of the First Florida Space Summit, participants gather around the poster. From left are Center Director Roy Bridges, Representative Jim Davis, Representative Dave Weldon, NASA Administrator Dan Goldin, Senator Connie Mack, Governor Jeb Bush, Senator Bob Graham and 45th Space Wing Commander Brig. Gen. Donald Pettit. The summit, which was held at the Kennedy Space Center Visitor Complex, featured key state officials and aerospace companies to discuss the future of space as it relates to the State of Florida. Moderated by Bridges, the event also included State Senator Patsy Kurth, State Senator Charlie Bronson, and State Representative Randy Ball.

  13. America's Promise Alliance Dropout Prevention Summits: Mobilizing Action to Address the High School Dropout Crisis Across the Nation

    ERIC Educational Resources Information Center

    Gifford, Beth; Evans, Kelly

    2011-01-01

    In this final evaluation of the America's Promise Dropout Prevention Summits, the evaluation reveals that the Summits not only served as the catalyst for the creation of new programs and collaborative efforts around ending the high school dropout crisis, but strengthened existing work, political and public awareness, and funding at the state,…

  14. The Superintendents' and Deans' Summit on Transformation and Collaboration for Student Success (April 22-23, 1997). Summary Report.

    ERIC Educational Resources Information Center

    Mid-Atlantic Lab. for Student Success, Philadelphia, PA.

    This publication provides an overview of the proceedings of the Superintendents' and Deans' Summit on Transformation and Collaboration for Student Success. The overarching goal of the Summit was to develop a formal mechanism for forging the professional expertise of field-based practitioners and college level professional education programs.…

  15. Managing recreation on mountain summits in the northern forest region of Maine, New Hampshire, New York, and Vermont

    Treesearch

    Kelly Goonan; Robert Manning; Carena J. van Riper; Christopher. Monz

    2010-01-01

    Land managers in the Northern Forest region of Maine, New Hampshire, New York, and Vermont face the challenge of providing high-quality recreation opportunities and experiences while also protecting fragile summit resources. The goals of this study were to identify indicators and standards of quality for visitor experiences and summit resources for three mountains with...

  16. Proceedings of the Teton Summit for Program Evaluation in Nonformal Environmental Education (Kelly, Wyoming, May 19-22, 2000).

    ERIC Educational Resources Information Center

    Wiltz, L. Kate

    This document contains the proceedings of the Teton Summit Conference for Program Evaluation in Nonformal Environmental Education. The Summit was co-hosted by the Teton Science School (TSS) and The Ohio State University with the goal of improving efficacy of evaluation in environmental education. Contents include: (1) What Is Evaluation? (2) For…

  17. Talent Development Research, Policy, and Practice in Europe and the United States: Outcomes from a Summit of International Researchers

    ERIC Educational Resources Information Center

    Subotnik, Rena F.; Stoeger, Heidrun; Olszewski-Kubilius, Paula

    2017-01-01

    The goal of this article is to convey a summary of research and conversation on talent development on the part of a small group of European and American researchers who participated in the Inaugural American European Research Summit in Washington. In the final hours of the summit, participants discussed the state of research on talent development…

  18. Restoring the Trust in Native Education. Annual NIEA Legislative Summit (14th, February 7-9, 2011). Briefing Papers

    ERIC Educational Resources Information Center

    National Indian Education Association, 2011

    2011-01-01

    Several briefing papers were presented during the 14th Annual National Indian Education Association (NIEA) Legislative Summit. This briefing book contains the following papers presented during the summit: (1) Restoring the Trust in Native Education; (2) NIEA Legislative Priorities for 2011: "Talking Points"; (3) Reauthorization of the…

  19. Leading Meetings.

    ERIC Educational Resources Information Center

    Lindelow, John; Heynderickx, James

    Chapter 13 of a revised volume on school leadership, this chapter offers suggestions to help educators improve their performance in meetings, both as group leaders and as participants. Well-run meetings can rejuvenate an organization, leading to improved teamwork, communication, and morale. A poor meeting, on the other hand, can have a…

  20. Managing Meetings

    ERIC Educational Resources Information Center

    Hay, Susan

    2010-01-01

    Meetings are a means of giving people a chance to contribute. Meetings are also the nursery where the people's skills of listening, speaking, and building good working relationships are honed. They are where people practice being courteously challenging and confident, and they are where people are fascinated and fascinating. Meetings are where…

  1. The effect of angiotensin-converting enzyme genotype on acute mountain sickness and summit success in trekkers attempting the summit of Mt. Kilimanjaro (5,895 m).

    PubMed

    Kalson, Nicholas S; Thompson, Julian; Davies, Andrew J; Stokes, Suzy; Earl, Mark D; Whitehead, Adam; Tyrrell-Marsh, Ian; Frost, Hannah; Montgomery, Hugh

    2009-02-01

    The I-allele rather than the D-allele of the human angiotensin converting enzyme (ACE) gene has been associated with high-altitude mountaineering success. We investigated whether the I-allele was associated with summit success, and also with AMS development, in altitude-naïve trekkers. Subjects ascended from 1,860 m to the summit over 4 days (n = 34, 'direct-profile') or 5 days (n = 82, 'slower-profile'). Proportionally more II direct-profile subjects were successful than ID or DD, although the difference was not significant (100% of II subjects, 52% ID and 43% DD, P = 0.09). There was no difference in success amongst subjects on the slower-profile (50% II, 45% ID and 58% DD, P = 0.54). There was a non-significant trend for increasing AMS scores in ID/DD subjects. Amongst tourist trekkers on Mt. Kilimanjaro the I-allele is not associated with summit success. No evidence is found to support an association between ACE genotype and AMS development.

  2. Carbon dioxide emission rate of Kīlauea Volcano: Implications for primary magma and the summit reservoir

    USGS Publications Warehouse

    Gerlach, T.M.; McGee, K.A.; Elias, T.; Sutton, A.J.; Doukas, M.P.

    2002-01-01

     We report a CO2 emission rate of 8500 metric tons per day (t d−1) for the summit of Kīlauea Volcano, several times larger than previous estimates. It is based on three sets of measurements over 4 years of synchronous SO2 emission rates and volcanic CO2/SO2concentration ratios for the summit correlation spectrometer (COSPEC) traverse. Volcanic CO2/SO2 for the traverse is representative of the global ratio for summit emissions. The summit CO2 emission rate is nearly constant, despite large temporal variations in summit CO2/SO2 and SO2 emission rates. Summit CO2 emissions comprise most of Kīlauea's total CO2 output (∼9000 t d−1). The bulk CO2 content of primary magma determined from CO2emission and magma supply rate data is ∼0.70 wt %. Most of the CO2 is present as exsolved vapor at summit reservoir depths, making the primary magma strongly buoyant. Turbulent mixing with resident reservoir magma, however, prevents frequent eruptions of buoyant primary magma in the summit region. CO2 emissions confirm that the magma supply enters the edifice through the summit reservoir. A persistent several hundred parts per million CO2 anomaly arises from the entry of magma into the summit reservoir beneath a square kilometer area east of Halemaumau pit crater. Since most of the CO2 in primary magma is degassed in the summit, the summit CO2 emission rate is an effective proxy for the magma supply rate. Both scrubbing of SO2 and solubility controls on CO2and S in basaltic melt cause high CO2/SO2 in summit emissions and spatially uncorrelated distributions of CO2 and SO2 in the summit plume.

  3. Focus on Global Education: A Report from the 2007 PDK Summit

    ERIC Educational Resources Information Center

    Young, Erin

    2008-01-01

    In panel discussions and brainstorming sessions, participants at PDK's Summit on Global Education shared their ideas for ensuring that a global perspective becomes an integral part of teaching and learning. Ms. Young was on the scene and summarizes the many angles that were addressed.

  4. The NATO Warsaw Summit: How to Strengthen Alliance Cohesion (Strategic Forum, Number 296)

    DTIC Science & Technology

    2016-06-01

    multiple crises including Russian revanchism, mass migration, and terrorism . Summit preparations are also taking place under the shadow of potential...Eastern flank gets di- luted to some extent. Concerns over the high North, the South Atlantic, the Sahel, or homegrown terrorism are all legitimate.15

  5. 77 FR 6534 - Malheur National Forest; Oregon; Summit Logan Grazing Authorization Project

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-08

    ... Forest Service Malheur National Forest; Oregon; Summit Logan Grazing Authorization Project AGENCY: Forest..., Oregon and encompasses approximately 40,272 acres of National Forest System Lands administered by the..., Environmental Coordinator, Malheur National Forest, 327 Front Street, P.O. Box 337, Prairie City, Oregon...

  6. Mars Summit Explores Options for Human Missions to the Red Planet

    NASA Astrophysics Data System (ADS)

    Showstack, Randy

    2013-05-01

    The United States "needs to begin the homesteading and settlement of Mars," Edwin "Buzz" Aldrin told participants at the Humans to Mars Summit on 8 May in Washington, D. C. "It is within reach technically and budgetarily. Even in a period of fiscal challenges, the United States needs to consider this program with long-term planning."

  7. Berkeley's 'Best-Kept' Secret: National Summit Seeks to Involve Youth in How Communities Are Redeveloped

    ERIC Educational Resources Information Center

    Burdman, Pamela

    2004-01-01

    Bringing together youth and adults from 15 Hope VI projects around the country, the Youth Leadership for Change is the third national summit of its kind. HUD used to fund the program, but now support comes from the Annie E. Casey Foundation, the Robert Wood Johnson Foundation and the San Francisco Foundation. At least some participants say the…

  8. 77 FR 30050 - VASRD Status Summit: A Public Overview of Proposed Disability Evaluation Criteria

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-21

    ... following nine body systems: (1) The Hemic and Lymphatic Systems (38 CFR 4.117), (2) The Endocrine System... Summit is to capture public comments on working drafts of proposed regulations for nine body ] systems... their input, prior to the drafting of proposed regulations for the body systems. VA plans to use...

  9. 77 FR 22221 - Security Zones; North Atlantic Treaty Organization (NATO) Summit, Chicago, IL

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-13

    ...) Summit, Chicago, IL AGENCY: Coast Guard, DHS. ACTION: Temporary final rule. SUMMARY: The Coast Guard is establishing four separate security zones on both the waters and waterfront area of Chicago Harbor and the Chicago River. These temporary security zones are intended to restrict vessels, regardless of the mode of...

  10. Berkeley's 'Best-Kept' Secret: National Summit Seeks to Involve Youth in How Communities Are Redeveloped

    ERIC Educational Resources Information Center

    Burdman, Pamela

    2004-01-01

    Bringing together youth and adults from 15 Hope VI projects around the country, the Youth Leadership for Change is the third national summit of its kind. HUD used to fund the program, but now support comes from the Annie E. Casey Foundation, the Robert Wood Johnson Foundation and the San Francisco Foundation. At least some participants say the…

  11. The African American Women's Summit: A Student Affairs Professional Development Program

    ERIC Educational Resources Information Center

    West, Nicole M.

    2017-01-01

    The African American Women's Summit (AAWS) is a professional development program in the United States created by and for African American women in student affairs. This article reviews the evolution and structure of the AAWS. A discussion, grounded in Black feminist thought, is included relative to the impact of the AAWS on African American women…

  12. Update on Exercise-Induced Asthma. A Report of the Olympic Exercise Asthma Summit Conference.

    ERIC Educational Resources Information Center

    Storms, William W.; Joyner, David M.

    1997-01-01

    Summarizes results from the Olympic Exercise Asthma Summit Conference, offering the latest on identifying and managing exercise-induced asthma (EIA). Concludes that effective pharmacologic and nonpharmacologic treatment is available, but EIA is underrecognized and underdiagnosed. Physicians should look for it in all patients, including school…

  13. Adding a Community University Educational Summit (CUES) to Enhance Service Learning in Management Education

    ERIC Educational Resources Information Center

    Levitt, Catherine; Schriehans, Cynthia

    2010-01-01

    For this study, one hundred and twenty student reflection papers (undergraduate and graduate) from a service learning extracurricular event titled, "Community University Educational Summit" (CUES) was analyzed. Over a two-year period, this event was held on one Saturday during the month of October at California State University San…

  14. Using Film Clips to Teach Teen Pregnancy Prevention: "The Gloucester 18" at a Teen Summit

    ERIC Educational Resources Information Center

    Herrman, Judith W.; Moore, Christopher C.; Anthony, Becky

    2012-01-01

    Teaching pregnancy prevention to large groups offers many challenges. This article describes the use of film clips, with guided discussion, to teach pregnancy prevention. In order to analyze the costs associated with teen pregnancy, a film clip discussion session based with the film "The Gloucester 18" was the keynote of a youth summit. The lesson…

  15. Discovering Africa through Internet-Based Geographic Information Systems: A Pan-African Summit Simulation

    ERIC Educational Resources Information Center

    Milson, Andrew J.; Gilbert, Kathleen M.; Earle, Brian D.

    2007-01-01

    In the United States, people get very little news about Africa, and what news they do get is about war or famine, with little historical information or context. In this article, the authors describe how they developed and implemented a Pan-African Summit simulation project in order to give their approximately 100, 9th-grade students (in five World…

  16. Educating Urban Indians: A Summit for the Future (Milwaukee, Wisconsin, March 10, 2000).

    ERIC Educational Resources Information Center

    Indian Community School of Milwaukee, Inc., WI.

    A March 2000 education summit brought together educators, parents, and community leaders to discuss key issues in the education of American Indian and Alaska Native students who attend school in urban areas. This summary report provides an overview of the main points discussed in a keynote address and four panel discussions. The keynote address by…

  17. MONDAY: EPA Co-Hosts First National Food Recovery Summit in Charleston, S.C.

    EPA Pesticide Factsheets

    Washington, D.C. - The first national Food Recovery Summit will take place next week in Charleston, S.C. Inspired by the national goal announced by EPA and U.S. Department of Agriculture to cut wasted food in half by 2030, partners from all facets of the f

  18. Using Film Clips to Teach Teen Pregnancy Prevention: "The Gloucester 18" at a Teen Summit

    ERIC Educational Resources Information Center

    Herrman, Judith W.; Moore, Christopher C.; Anthony, Becky

    2012-01-01

    Teaching pregnancy prevention to large groups offers many challenges. This article describes the use of film clips, with guided discussion, to teach pregnancy prevention. In order to analyze the costs associated with teen pregnancy, a film clip discussion session based with the film "The Gloucester 18" was the keynote of a youth summit. The lesson…

  19. Geologic Mapping of the Summit and Western Flank of Alba Mons, Mars

    NASA Astrophysics Data System (ADS)

    Crown, D. A.; Berman, D. C.; Platz, T.; Scheidt, S. P.; Hauber, E.; Weitz, C. M.

    2017-06-01

    This investigation employs imaging and topographic datasets to produce two 1:1M-scale geologic maps covering the Alba Mons summit (245-255°E, 32.5-47.5°N) and western flank (230-245°E, 37.5-47.5°N).

  20. Blazing the Trail: A New Direction for Youth Development & Leadership. Summit Report

    ERIC Educational Resources Information Center

    Hare, R.; Richards, C.

    2007-01-01

    The Blazing the Trail summit provided a unique experience for a national dialogue on actions that need to be taken to improve policy and practice in the youth development and leadership field, and to ensure that youth with disabilities (including those with mental health needs), are included in opportunities available to all youth. The report…

  1. Leadership Summit to Effect Change in Teaching and Learning: Undergraduate Education in Agriculture

    ERIC Educational Resources Information Center

    Fagen, Adam P.; Schoen, Robin; Labov, Jay B.

    2007-01-01

    This article reports on a convention held at the National Academy of Sciences in Washington, DC, on October 3-5, 2006, to discuss the current status and future of undergraduate education in agriculture. This "Leadership Summit to Effect Change in Teaching and Learning" was a first step in what is planned to be an ongoing conversation…

  2. Reconstructing English Education for the 21st Century: A Report on the CEE Summit

    ERIC Educational Resources Information Center

    Miller, Suzanne M.; Fox, Dana L.

    2006-01-01

    The coeditors of the special Summit issue of English Education provide the context for the "crucial moment" that prompted the Conference on English Education (CEE) to take up the task of rethinking issues related to the preparation and continuing professional development of English language arts teachers and teacher educators. The process of…

  3. Scholarship in Student Affairs Revisited: The Summit on Scholarship, March 2006

    ERIC Educational Resources Information Center

    Jablonski, Margaret A.; Mena, Salvador B.; Manning, Kathleen; Carpenter, Stan; Siko, Kari Lee

    2006-01-01

    Over the past 5 years, ACPA and NASPA have promoted conversations about an exploration of scholarship in the field through dedicated special issues of their journals (2001 and 2002 respectively) to the topic. The leadership of NASPA called a "summit" in 2006 for scholars and practitioners to gather and discuss the state of scholarship in the field…

  4. Ancient tepui summits harbor young rather than old lineages of endemic frogs.

    PubMed

    Salerno, Patricia E; Ron, Santiago R; Señaris, J Celsa; Rojas-Runjaic, Fernando J M; Noonan, Brice P; Cannatella, David C

    2012-10-01

    The flattop mountains (tepuis) of South America are ancient remnants of the Precambrian Guiana Shield plateau. The tepui summits, isolated by their surrounding cliffs that can be up to 1000 m tall, are thought of as "islands in the sky," harboring relict flora and fauna that underwent vicariant speciation due to plateau fragmentation. High endemicity atop tepui summits support the idea of an ancient "Lost World" biota. However, recent work suggests that dispersal between lowlands and summits has occurred long after tepui formation indicating that tepui summits may not be as isolated from the lowlands as researchers have long suggested. Neither view of the origin of the tepui biota (i.e., ancient vicariance vs. recent dispersal) has strong empirical support owing to a lack of studies. We test diversification hypotheses of the Guiana Shield highlands by estimating divergence times of an endemic group of treefrogs, Tepuihyla. We find that diversification of this group does not support an ancient origin for this taxon; instead, divergence times among the highland species are 2-5 Ma. Our data indicate that most highland speciation occurred during the Pliocene. Thus, this unparalleled landscape known as "The Lost World" is inhabited, in part, not by Early Tertiary relicts but neoendemics.

  5. Summary of the 2015 International Paediatric Heart Failure Summit of Johns Hopkins All Children's Heart Institute.

    PubMed

    Jacobs, Jeffrey P; Quintessenza, James A; Karl, Tom R; Asante-Korang, Alfred; Everett, Allen D; Collins, Susan B; Ramirez-Correa, Genaro A; Burns, Kristin M; Cohen, Mitchell; Colan, Steven D; Costello, John M; Daly, Kevin P; Franklin, Rodney C G; Fraser, Charles D; Hill, Kevin D; Huhta, James C; Kaushal, Sunjay; Law, Yuk M; Lipshultz, Steven E; Murphy, Anne M; Pasquali, Sara K; Payne, Mark R; Rossano, Joseph; Shirali, Girish; Ware, Stephanie M; Xu, Mingguo; Jacobs, Marshall L

    2015-08-01

    In the United States alone, ∼14,000 children are hospitalised annually with acute heart failure. The science and art of caring for these patients continues to evolve. The International Pediatric Heart Failure Summit of Johns Hopkins All Children's Heart Institute was held on February 4 and 5, 2015. The 2015 International Pediatric Heart Failure Summit of Johns Hopkins All Children's Heart Institute was funded through the Andrews/Daicoff Cardiovascular Program Endowment, a philanthropic collaboration between All Children's Hospital and the Morsani College of Medicine at the University of South Florida (USF). Sponsored by All Children's Hospital Andrews/Daicoff Cardiovascular Program, the International Pediatric Heart Failure Summit assembled leaders in clinical and scientific disciplines related to paediatric heart failure and created a multi-disciplinary "think-tank". The purpose of this manuscript is to summarise the lessons from the 2015 International Pediatric Heart Failure Summit of Johns Hopkins All Children's Heart Institute, to describe the "state of the art" of the treatment of paediatric cardiac failure, and to discuss future directions for research in the domain of paediatric cardiac failure.

  6. Discovering Africa through Internet-Based Geographic Information Systems: A Pan-African Summit Simulation

    ERIC Educational Resources Information Center

    Milson, Andrew J.; Gilbert, Kathleen M.; Earle, Brian D.

    2007-01-01

    In the United States, people get very little news about Africa, and what news they do get is about war or famine, with little historical information or context. In this article, the authors describe how they developed and implemented a Pan-African Summit simulation project in order to give their approximately 100, 9th-grade students (in five World…

  7. Rapid Review Summit: an overview and initiation of a research agenda.

    PubMed

    Polisena, Julie; Garritty, Chantelle; Umscheid, Craig A; Kamel, Chris; Samra, Kevin; Smith, Jeannette; Vosilla, Ann

    2015-09-26

    The demand for accelerated forms of evidence synthesis is on the rise, largely in response to requests by health care decision makers for expeditious assessment and up-to-date information about health care technologies and health services and programs. As a field, rapid review evidence synthesis is marked by a tension between the strategic priority to inform health care decision-making and the scientific imperative to produce robust, high-quality research that soundly supports health policy and practice. In early 2015, the Canadian Agency for Drugs and Technologies in Health convened a forum in partnership with the British Columbia Ministry of Health, the British Columbia Centre for Clinical Epidemiology and Evaluation, the Ottawa Hospital Research Institute, and the University of Pennsylvania. More than 150 evidence synthesis producers and end users attended the Rapid Review Summit: Then, Now and in the Future. The Summit program focused on the evolving role and practices of rapid reviews to support informed health care policy and clinical decision-making, including the uptake and use of health technology assessment. Our discussion paper highlights the important discussions that occurred during the Rapid Review Summit. It focuses on the initial development of a research agenda that resulted from the Summit presentations and discussions. The research topics centered on three key areas of interest: (1) how to conduct a rapid review; (2) investigating the validity and utility of rapid reviews; and (3) how to improve access to rapid reviews.

  8. Focus on Global Education: A Report from the 2007 PDK Summit

    ERIC Educational Resources Information Center

    Young, Erin

    2008-01-01

    In panel discussions and brainstorming sessions, participants at PDK's Summit on Global Education shared their ideas for ensuring that a global perspective becomes an integral part of teaching and learning. Ms. Young was on the scene and summarizes the many angles that were addressed.

  9. Case Study: Lee's Summit West High School--Empowering Students to Succeed

    ERIC Educational Resources Information Center

    Southern Regional Education Board (SREB), 2014

    2014-01-01

    The Southern Regional Education Board's (SREB's) case study series highlights best practices High Schools That Work (HSTW) network schools and districts are implementing to better prepare students for further studies and careers. Lee's Summit West (LSW) High School near Kansas City, Missouri, boasts of a 99 percent graduation rate; 93 percent of…

  10. The 13th Annual Legislative Summit (Washington, DC, 2010). Briefing Papers

    ERIC Educational Resources Information Center

    National Indian Education Association, 2010

    2010-01-01

    This volume contains briefing papers presented at the 13th Annual National Indian Education Association (NIEA) Legislative Summit held in Washington, DC. The following papers are included: (1) NIEA Appropriations Priorities for FY11; (2) The President's Budget Request for Fiscal Year 2011 for Native Education; (3) BIE Race to the Top; (4)…

  11. Re-Envisioning Business Programs in Liberal Arts Worlds: 2006 Summit Proceeding & Outcomes

    ERIC Educational Resources Information Center

    Neville, Mary Grace, Comp.; Godwin, Lindsey, Comp.; Senchack, A.J., Comp.; Parks, Don, Comp.

    2007-01-01

    This report compiles primary and secondary research about the role of business education in undergraduate liberal arts institutions. Grounded in history, literature and the ongoing dialogue about the role of business education in society, the report also serves as proceedings from a multi-university summit held in November 2006 at Southwestern…

  12. A call to action: bold ideas from the Minnesota Women's Heart Summit.

    PubMed

    Ali, Nora; Lindquist, Ruth; Boucher, Jackie L; Witt, Dawn; Ambroz, Teresa; Konety, Suma H; Luepker, Russell; Windenburg, Denise; Hayes, Sharonne N

    2012-05-01

    Minnesota has the lowest overall coronary heart disease mortality rate in the United States. Yet disparities between men and women persist with regard to prevention, detection, and treatment. This has led to a gender gap not only in terms of care but also in survival rates. In an effort to better understand and close the gender gap, the Minneapolis Heart Institute, the Minneapolis Heart Institute Foundation, the University of Minnesota, and Mayo Clinic hosted a multidisciplinary Women's Heart Summit in April 2010. The goals of the summit were to stimulate dialogue and devise strategies to eliminate untimely deaths of women from heart disease. Summit participants were asked to contribute suggestions--called "Bold Ideas"--to address sex-based differences in the prevention, detection, and treatment of heart disease. Ideas were categorized according to three themes: educational programming, modifications to the health care system, and government involvement and funding. From these, several solutions emerged: 1) Involve obstetric/gynecologic physicians in providing heart-health education; 2) involve mid-level providers (midwives and other advanced practice women's health care providers) and other health professionals in women's heart health education, and 3) maximize the use of social media and online newsfeeds to raise awareness of heart disease in women. This article summarizes the discussion of the main ideas submitted by summit participants.

  13. Reconstructing English Education for the 21st Century: A Report on the CEE Summit

    ERIC Educational Resources Information Center

    Miller, Suzanne M.; Fox, Dana L.

    2006-01-01

    The coeditors of the special Summit issue of English Education provide the context for the "crucial moment" that prompted the Conference on English Education (CEE) to take up the task of rethinking issues related to the preparation and continuing professional development of English language arts teachers and teacher educators. The process of…

  14. Third European Influenza Summit: organized by the European Scientific Working group on Influenza (ESWI).

    PubMed

    McElhaney, Janet; Osterhaus, Ab

    2013-12-16

    On 2 May 2013, the European Scientific Working group on Influenza (ESWI) held its third influenza summit at the Institute of European Studies at the Free University of Brussels. ESWI brought together more than 90 representatives of organizations of healthcare providers, senior citizens, at-risk patients and public health authorities for a day of tailored lectures, Q&A sessions and networking. Since recent studies, surveys and reviews have shed new light on some of the most intriguing influenza issues, the Summit faculty translated the newest scientific data into practice. The first part of the Summit programme focused on the current flu status in Europe, paying special attention to the protection of pregnant women and the elderly as well as to the issues of vaccine safety and effectiveness. The programme continued to highlight future challenges and evolutions like novel antiviral drugs against influenza, improved flu vaccines and the prospect of a universal flu vaccine. The annual ESWI flu summits are the pinnacles of ESWI's efforts to bridge the gap between science and society. ESWI's members are convinced that the fight against influenza can only be won when all parties are well informed and ready to work together.

  15. A new paradigm for Summit: enhanced traverse capabilities and satellite camps.`

    NASA Astrophysics Data System (ADS)

    Hawley, R. L.; Burkhart, J. F.; Courville, Z.; Dibb, J. E.

    2013-12-01

    Summit Station began its life at the summit of the Greenland Ice Sheet (72°N, 38°W, 3200 m.a.s.l.), as the drilling camp for the GISP2 ice core in 1989. Since then, the station has hosted both summer campaign science, and since 1997, year-round observations of atmospheric and cryospheric processes, both chemical and physical. After "experimental" winter seasons in 1997-98 and 2000-2002, the station has been continuously occupied since 2003. While most of the science activities at the station are supported by the US NSF Polar Division, the station also hosts many interagency and international investigations in physical glaciology, atmospheric chemistry, and other disciplines. Projects requiring access to the only high elevation observatory North of the Arctic circle providing clean air or snow for chemistry experiments will find Summit a unique and suitable location. In addition to investigator-driven projects, Summit hosts a cooperative NOAA-NSF Long Term Observatory (LTO) program committed to maintaining year-round measurements of key baseline variables of climate change at the site., The facility is operated by CH2M HILL Polar Services (CPS) with guidance from the Science Coordination Office (SCO), and the cooperation of the Government of Greenland. Facility support is primarily from NSF ARSL. Summit has historically served as a logistical hub for wider-ranging field studies in central Greenland and also stationary projects seeking a convenient location in the dry-snow zone. These functions conflict with the goal of reducing emissions at Summit in support of clean science. In recent years and into the future, projects without a need for the unique clean-snow / air characteristics will be increasingly directed to alternate locations in the dry-snow zone. These locations include a new logistical-hub to the north that will serve as the base of operations for projects not requiring a direct connection to the historical climate records of Summit , or locations

  16. Report of the first Asia-Pacific influenza summit, Asia-Pacific Alliance for the Control of Influenza (APACI), Bangkok, 12-13 June 2012.

    PubMed

    Jennings, Lance C; Smith, David W; Chan, Paul K S

    2013-11-01

    On June 12-13, 2012, the Asia-Pacific Alliance for the Control of Influenza (APACI) convened jointly with the Influenza Foundation of Thailand and the Thailand Department of Disease Control, the First Asia-Pacific Influenza Summit. The objectives of the meeting were to review the current state of official influenza control policies in Asia-Pacific countries; identify, summarize and communicate influenza control strategies that have successfully increased vaccine uptake in the region; develop policy and advocacy approaches to improve influenza vaccine uptake in high-risk groups and healthcare workers in the region; and establish collaborative relationships to promote best practices for the control of influenza. In moving forward, the challenge for the region will be establishing collaborations able to effectively communicate risk and key messages about influenza vaccination.

  17. Electricity: The Energy of Tomorrow (A "Life at the Frontiers of Energy Research" contest entry from the 2011 Energy Frontier Research Centers (EFRCs) Summit and Forum)

    SciTech Connect

    Abruna, Hector D.; emc2 Staff

    2011-05-01

    'Electricity: the Energy of Tomorrow' was submitted by the Energy Materials Center at Cornell (emc2) to the 'Life at the Frontiers of Energy Research' video contest at the 2011 Science for Our Nation's Energy Future: Energy Frontier Research Centers (EFRCs) Summit and Forum. Twenty-six EFRCs created short videos to highlight their mission and their work. emc2, an EFRC directed by Hector D. Abruna at Cornell University (lead) is a partnership between Cornell and Lawrence Berkeley National Laboratory. The Office of Basic Energy Sciences in the U.S. Department of Energy's Office of Science established the 46 Energy Frontier Research Centers (EFRCs) in 2009. These collaboratively-organized centers conduct fundamental research focused on 'grand challenges' and use-inspired 'basic research needs' recently identified in major strategic planning efforts by the scientific community. The overall purpose is to accelerate scientific progress toward meeting the nation's critical energy challenges.

  18. Millennium Pharma Summit--strategic planning to increase growth and generate pharmaceutical shareholder value. 26-27 January 2000, London, UK.

    PubMed

    Worker, C; Kibble, A

    2000-05-01

    With mergers and acquisitions (M&As) being the 'watch words' of the moment among those involved in the pharmaceutical industry, this meeting aimed to bring together the senior hierarchy of both medium and big pharma to discuss the issues pertinent to competitive survival and shareholder profit delivery. Along with a more objective analysis delivered by a number of management consultancy representatives, the summit presented delegates with interesting and often controversial viewpoints on: strategic partnerships and alliances; developing organizational models to generate profitability; the promotion of innovative R&D to maximize shareholder value; the development of marketing strategies in line with increasing consumer power; and, past, present and future consequences for the industry as a result of 'merger mania'.

  19. Electricity: The Energy of Tomorrow (A "Life at the Frontiers of Energy Research" contest entry from the 2011 Energy Frontier Research Centers (EFRCs) Summit and Forum)

    ScienceCinema

    Abruna, Hector D. (Director, Energy Materials Center at Cornell); emc2 Staff

    2016-07-12

    'Electricity: the Energy of Tomorrow' was submitted by the Energy Materials Center at Cornell (emc2) to the 'Life at the Frontiers of Energy Research' video contest at the 2011 Science for Our Nation's Energy Future: Energy Frontier Research Centers (EFRCs) Summit and Forum. Twenty-six EFRCs created short videos to highlight their mission and their work. emc2, an EFRC directed by Hector D. Abruna at Cornell University (lead) is a partnership between Cornell and Lawrence Berkeley National Laboratory. The Office of Basic Energy Sciences in the U.S. Department of Energy's Office of Science established the 46 Energy Frontier Research Centers (EFRCs) in 2009. These collaboratively-organized centers conduct fundamental research focused on 'grand challenges' and use-inspired 'basic research needs' recently identified in major strategic planning efforts by the scientific community. The overall purpose is to accelerate scientific progress toward meeting the nation's critical energy challenges.

  20. PARC - Scientific Exchange Program (A "Life at the Frontiers of Energy Research" contest entry from the 2011 Energy Frontier Research Centers (EFRCs) Summit and Forum)

    ScienceCinema

    Blankenship, Robert E. (Director, Photosynthetic Antenna Research Center); PARC Staff

    2016-07-12

    'PARC - Scientific Exchange Program' was submitted by the Photosynthetic Antenna Research Center (PARC) to the 'Life at the Frontiers of Energy Research' video contest at the 2011 Science for Our Nation's Energy Future: Energy Frontier Research Centers (EFRCs) Summit and Forum. Twenty-six EFRCs created short videos to highlight their mission and their work. PARC, an EFRC directed by Robert E. Blankenship at Washington University in St. Louis, is a partnership of scientists from ten institutions. The Office of Basic Energy Sciences in the U.S. Department of Energy's Office of Science established the 46 Energy Frontier Research Centers (EFRCs) in 2009. These collaboratively-organized centers conduct fundamental research focused on 'grand challenges' and use-inspired 'basic research needs' recently identified in major strategic planning efforts by the scientific community. The overall purpose is to accelerate scientific progress toward meeting the nation's critical energy challenges.

  1. Mapping Lithologic Units Exposed on the Summit of Mauna Kea Using AVIRIS Hyperspectral Reflectance Data

    NASA Technical Reports Server (NTRS)

    Guinness, E. A.; Arvidson, R. E.; Jolliff, B. L.; Morris, R. V.; Ming, D. W.

    2002-01-01

    The Mauna Kea summit region is largely comprised of cinder cones and lava flows that form the cap of the Mauna Kea Volcano. The cones and flows at the summit are part of the Laupahoehoe Volcanic series. The Laupa hoehoe volcanism occurred both during and after the late Pleistocene Makanaka glacial episode at the summit. In addition, a few Laupahoehoe cones have been glacially eroded as evidenced by oversteepened slopes, which suggests that they predate the Makanaka glacial period. Two notable examples of possible preglacial cones are Puu Waiau and Puu Poliahu. These two cones are also significantly altered, most likely by hydrothermal activity that has weakly cemented the materials on the cones. Well-crystalline sulfates (alunite and jarosite), phyllosilicates, and zeolites, have been found in samples collected from altered cones at the summit. In addition, palagonitic tephra, which have nanophase ferric oxide, allophane, and other poorly crystalline forms of weakly altered basaltic glass (i.e., no phyllosilicates), have been described at several locations on Mauna Kea. While several studies have discussed the occurrence of alteration products on Mauna Kea, the distribution of these materials exposed at the summit has not been extensively mapped. Hyperspectral imaging can provide information for identifying and mapping lithologic units containing alteration minerals, such as are found on Mauna Kea. The Airborne Visible Infrared Imaging Spectrometer (AVIRIS) is a hyperspectral imaging instrument that covers the wavelength range from about 0.4 to 2.5 micron in 224 bands, with a band spacing of 10 nm and average band width of 10 nm

  2. Mapping Lithologic Units Exposed on the Summit of Mauna Kea Using AVIRIS Hyperspectral Reflectance Data

    NASA Technical Reports Server (NTRS)

    Guinness, E. A.; Arvidson, R. E.; Jolliff, B. L.; Morris, R. V.; Ming, D. W.

    2002-01-01

    The Mauna Kea summit region is largely comprised of cinder cones and lava flows that form the cap of the Mauna Kea Volcano. The cones and flows at the summit are part of the Laupahoehoe Volcanic series. The Laupa hoehoe volcanism occurred both during and after the late Pleistocene Makanaka glacial episode at the summit. In addition, a few Laupahoehoe cones have been glacially eroded as evidenced by oversteepened slopes, which suggests that they predate the Makanaka glacial period. Two notable examples of possible preglacial cones are Puu Waiau and Puu Poliahu. These two cones are also significantly altered, most likely by hydrothermal activity that has weakly cemented the materials on the cones. Well-crystalline sulfates (alunite and jarosite), phyllosilicates, and zeolites, have been found in samples collected from altered cones at the summit. In addition, palagonitic tephra, which have nanophase ferric oxide, allophane, and other poorly crystalline forms of weakly altered basaltic glass (i.e., no phyllosilicates), have been described at several locations on Mauna Kea. While several studies have discussed the occurrence of alteration products on Mauna Kea, the distribution of these materials exposed at the summit has not been extensively mapped. Hyperspectral imaging can provide information for identifying and mapping lithologic units containing alteration minerals, such as are found on Mauna Kea. The Airborne Visible Infrared Imaging Spectrometer (AVIRIS) is a hyperspectral imaging instrument that covers the wavelength range from about 0.4 to 2.5 micron in 224 bands, with a band spacing of 10 nm and average band width of 10 nm

  3. An Ophthalmologic Summit for On-Orbit Care

    NASA Technical Reports Server (NTRS)

    Bacal, Kira; McCulley, Phyllis; Paul, Bonnie

    2004-01-01

    Ophthalmologic issues are a source of concern for NASA flight surgeons, due to the remote nature of the space station as well as the microg ravity environment. Methods: A panel of external consultants was conv ened to evaluate the adequacy of the current in-flight medical system for the diagnosis and treatment of ophthalmologic issues. Participants were acknowledged experts in their field who also had experience in operational medicine. Results: Nine extramural experts provided assi stance, and six of them participated in a face to face meeting held a t NASA-Johnson Space Center. Changes were recommended for the space s tation pharmacopoeia, and diagnostic, therapeutic, and deorbit criteria protocols for a variety of ocular conditions were developed. Discus sion: The results of the panel provide an evidence based approach to the diagnosis and care of ophthalmologic conditions on the International Space Station

  4. Lawmakers: population and social development inseparable. Social development summit.

    PubMed

    1995-05-01

    Parliamentarians from around the world endorsed action to promote social development by approving the Copenhagen Statement on Population and Social Development during the International Meeting of Parliamentarians on Population and Social Development held at the National Parliament in Copenhagen, Denmark, March 4-5, 1995. The International Conference of Parliamentarians on Population and Development is a similar meeting held ahead of the International Conference on Population and Development during September 1994 in Cairo, Egypt. Among the key points of the Copenhagen Statement is the recognition of the importance of slowing rapid population growth, eradicating poverty, protecting the environment, creating jobs, and promoting social integration so that people can participate equally and fully in all spheres of social, cultural, economic, and political life. The document also acknowledges the need to promote universal access to education and health care, affirms the 20/20 principle as an useful concept against poverty and in development cooperation, and notes South-South cooperation as a means to promote national and international cooperation. Shin Sakurai, chairman of the Asian Forum of Parliamentarians on Population and Development, presided over the event and led the Japanese delegation of four legislators. The first such national suprapartisan body of lawmakers concerned with population and development, the Japan Parliamentarians Federation for Population was established in 1974. The federation has since been a pioneer in Asia and worldwide in fostering political commitment on population and development, playing an important role in gaining and maintaining support in Japan for multilateral and bilateral assistance in the field. Sakurai stressed in his March 4 address that population problems cannot be resolved without social development.

  5. International Pediatric MS Study Group Clinical Trials Summit

    PubMed Central

    Tardieu, Marc; Amato, Maria Pia; Banwell, Brenda; Bar-Or, Amit; Ghezzi, Angelo; Kornberg, Andrew; Krupp, Lauren B.; Pohl, Daniela; Rostasy, Kevin; Tenembaum, Silvia; Waubant, Emmanuelle; Wassmer, Evangeline

    2013-01-01

    Objective: Pediatric studies for new biological agents are mandated by recent legislation, necessitating careful thought to evaluation of emerging multiple sclerosis (MS) therapies in children with MS. Challenges include a small patient population, the lack of prior randomized clinical trials, and ethical concerns. The goal of this meeting was to assess areas of consensus regarding clinical trial design and outcome measures among academic experts involved in pediatric MS care and research. Methods: The Steering Committee of the International Pediatric MS Study Group identified key focus areas for discussion. A total of 69 meeting attendees were assembled, including 35 academic experts. Regulatory and pharmaceutical representatives also attended, and provided input, which informed academic expert consensus decisions. Results: The academic experts agreed that clinical trials were necessary in pediatric MS to obtain pharmacokinetic, safety and efficacy data, and regulatory approval allowing for greater medication access. The academic experts agreed that relapse was an appropriate primary outcome measure for phase III pediatric trials. An international standardized cognitive battery was identified. The pros and cons of various trial designs were discussed. Guidelines surrounding MRI studies, pharmacokinetics, pharmacodynamics, and registries were developed. The academic experts agreed that given the limited subject pool, a stepwise approach to the launch of clinical trials for the most promising medications is necessary in order to ensure study completion. Alternative approaches could result in unethical exposure of patients to trial conditions without gaining knowledge. Conclusion: Consensus points for conduct of clinical trials in the rare disease pediatric MS were identified amongst a panel of academic experts, informed by regulatory and industry stakeholders. PMID:23509048

  6. Oximetry fails to predict acute mountain sickness or summit success during a rapid ascent to 5640 meters.

    PubMed

    Wagner, Dale R; Knott, Jonathan R; Fry, Jack P

    2012-06-01

    The purpose of this study was to determine whether arterial oxygen saturation (Spo(2)) and heart rate (HR), as measured by a finger pulse oximeter on rapid arrival to 4260 m, could be predictive of acute mountain sickness (AMS) or summit success on a climb to 5640 m. Climbers (35.0 ± 10.1 years; 51 men, 5 women) were transported from 2650 m to the Piedra Grande hut at 4260 m on Pico de Orizaba within 2 hours. After a median time of 10 hours at the hut, they climbed toward the summit (5640 m) and returned, with a median trip time of 14 hours. The Lake Louise Self-Assessment Scale (LLSS) for AMS, HR, and Spo(2) were collected on arrival at the hut and repeated immediately before and after the climbers' summit attempts. Average Spo(2) for all participants at 4260 m before their departure for the summit was 84.4% ± 3.7%. Thirty-seven of the 56 participants reached the summit, and 59% of all climbers met the criteria for AMS during the ascent. The Spo(2) was not significantly different between those who experienced AMS and those who did not (P = .82); neither was there a difference in Spo(2) between summiteers and nonsummiteers (P = .44). Climbers' HR just before the summit attempt was not related to AMS but was significantly lower for summiteers vs nonsummiteers (P = .04). The Spo(2) does not appear to be predictive of AMS or summit success during rapid ascents. Copyright © 2012 Wilderness Medical Society. Published by Elsevier Inc. All rights reserved.

  7. The Meta-Leadership Summit for Preparedness Initiative: An Innovative Model to Advance Public Health Preparedness and Response

    PubMed Central

    Sobelson, Robyn K.; Young, Andrea C.; Marcus, Leonard J.; Dorn, Barry C.; Neslund, Verla S.; McNulty, Eric J.

    2017-01-01

    This article reports on the design, evaluation framework, and results from the Meta-Leadership Summit for Preparedness Initiative. The Meta-Leadership Summit for Preparedness was a 5-year initiative based on the premise that national preparedness and emergency response is not solely the responsibility of government. From 2006 to 2011, 36 Meta-Leadership Summits were delivered in communities across the country. Summits were customized, 10-hour leadership development, networking, and community action planning events. They included participation from targeted federal, state, local, nonprofit/philanthropic, and private sector leaders who are directly involved in decision making during a major community or state-wide emergency. A total of 4,971 government, nonprofit, and business leaders attended Meta-Leadership Summits; distribution of attendees by sector was balanced. Ninety-three percent of respondents reported the summit was a valuable use of time, 91% reported the overall quality as “good” or “outstanding,” and 91% would recommend the summit to their colleagues. In addition, approximately 6 months after attending a summit, 80% of respondents reported that they had used meta-leadership concepts or principles. Of these, 93% reported that using meta-leadership concepts or principles had made a positive difference for them and their organizations. The Meta-Leadership Summit for Preparedness Initiative was a value-added opportunity for communities, providing the venue for learning the concepts and practice of meta-leadership, multisector collaboration, and resource sharing with the intent of substantively improving preparedness, response, and recovery efforts. PMID:24251597

  8. Identification of water-quality trends using sediment cores from Dillon Reservoir, Summit County, Colorado

    USGS Publications Warehouse

    Greve, Adrienne I.; Spahr, Norman E.; Van Metre, Peter C.; Wilson, Jennifer T.

    2001-01-01

    Since the construction of Dillon Reservoir, in Summit County, Colorado, in 1963, its drainage area has been the site of rapid urban development and the continued influence of historical mining. In an effort to assess changes in water quality within the drainage area, sediment cores were collected from Dillon Reservoir in 1997. The sediment cores were analyzed for pesticides, polychlorinated biphenyls (PCBs), polycyclic aromatic hydrocarbons (PAHs), and trace elements. Pesticides, PCBs, and PAHs were used to determine the effects of urban development, and trace elements were used to identify mining contributions. Water-quality and streambed-sediment samples, collected at the mouth of three streams that drain into Dillon Reservoir, were analyzed for trace elements. Of the 14 pesticides and 3 PCBs for which the sediment samples were analyzed, only 2 pesticides were detected. Low amounts of dichloro-diphenyldichloroethylene (DDE) and dichloro-diphenyldichloroethane (DDD), metabolites of dichlorodiphenyltrichloroethane (DDT), were found at core depths of 5 centimeters and below 15 centimeters in a core collected near the dam. The longest core, which was collected near the dam, spanned the entire sedimentation history of the reservoir. Concentrations of total combustion PAH and the ratio of fluoranthene to pyrene in the core sample decreased with core depth and increased over time. This relation is likely due to growth in residential and tourist populations in the region. Comparisons between core samples gathered in each arm of the reservoir showed the highest PAH concentrations were found in the Tenmile Creek arm, the only arm that has an urban area on its shores, the town of Frisco. All PAH concentrations, except the pyrene concentration in one segment in the core near the dam and acenaphthylene concentrations in the tops of three cores taken in the reservoir arms, were below Canadian interim freshwater sediment-quality guidelines. Concentrations of arsenic, cadmium

  9. Identification of water-quality trends using sediment cores from Dillon Reservoir, Summit County, Colorado

    USGS Publications Warehouse

    Greve, Adrienne I.; Spahr, Norman E.; Van Metre, Peter C.; Wilson, Jennifer T.

    2001-01-01

    Since the construction of Dillon Reservoir, in Summit County, Colorado, in 1963, its drainage area has been the site of rapid urban development and the continued influence of historical mining. In an effort to assess changes in water quality within the drainage area, sediment cores were collected from Dillon Reservoir in 1997. The sediment cores were analyzed for pesticides, polychlorinated biphenyls (PCBs), polycyclic aromatic hydrocarbons (PAHs), and trace elements. Pesticides, PCBs, and PAHs were used to determine the effects of urban development, and trace elements were used to identify mining contributions. Water-quality and streambed-sediment samples, collected at the mouth of three streams that drain into Dillon Reservoir, were analyzed for trace elements. Of the 14 pesticides and 3 PCBs for which the sediment samples were analyzed, only 2 pesticides were detected. Low amounts of dichloro-diphenyldichloroethylene (DDE) and dichloro-diphenyldichloroethane (DDD), metabolites of dichlorodiphenyltrichloroethane (DDT), were found at core depths of 5 centimeters and below 15 centimeters in a core collected near the dam. The longest core, which was collected near the dam, spanned the entire sedimentation history of the reservoir. Concentrations of total combustion PAH and the ratio of fluoranthene to pyrene in the core sample decreased with core depth and increased over time. This relation is likely due to growth in residential and tourist populations in the region. Comparisons between core samples gathered in each arm of the reservoir showed the highest PAH concentrations were found in the Tenmile Creek arm, the only arm that has an urban area on its shores, the town of Frisco. All PAH concentrations, except the pyrene concentration in one segment in the core near the dam and acenaphthylene concentrations in the tops of three cores taken in the reservoir arms, were below Canadian interim freshwater sediment-quality guidelines. Concentrations of arsenic, cadmium

  10. Slides from the 2013 Smart Growth Summit on How to Learn from the New Orleans Urban Waters Partnership

    EPA Pesticide Factsheets

    Presentation Slides for 2013 Smart Growth Summit, Baton Rouge, LA, H2O Overview: How to Learn from the New Orleans Urban Waters Partnership - Danny Wiegand Urban Waters Ambassador to New Orleans November 19, 2013

  11. Joy Development Properties, LLC, Pleasant Valley, Iowa and Summit Concrete, Inc., LeClaire, Iowa - Clean Water Act Public Notice

    EPA Pesticide Factsheets

    The EPA is providing notice of a proposed Administrative Penalty Assessment against Joy Development Properties, LLC and Summit Concrete, Inc., for alleged violations at the companies’ residential construction site known as the Schutter Farms Addition loca

  12. Raising the profile of worker safety: highlights of the 2013 North American Agricultural Safety Summit.

    PubMed

    Nelson, William J; Heiberger, Scott; Lee, Barbara C

    2014-01-01

    The 2013 North American Agricultural Safety Summit, an unprecedented gathering of industry leaders and safety experts, was held September 25-27 in Minneapolis, MN. Hosted by the industry-led Agricultural Safety and Health Council of America (ASHCA), there were 250 attendees, 82 speakers, 76 abstracts with poster presentations, along with "best practices" videos, genius bars sessions, learning stations, exhibits, breakfast roundtable topics, and receptions. The event was a mix of knowledge, inspiration and networking to enable participants to influence the adoption of safety practices in their home/work settings. Given the agriculture industry's commitment to feed nine billion people, the projected world population by 2050, it is imperative that producers and agribusiness strive to do it safely, humanely and sustainably. Evaluation feedback was very positive, indicating ASHCA's original objectives for the Summit were achieved.

  13. Shivering and non-shivering thermogenesis during summit metabolism in young lambs

    PubMed Central

    Alexander, G.; Williams, D.

    1968-01-01

    1. Summit metabolism of lambs declined steadily from about 3·5 l. O2/kg.hr during the first day of life, to about 2·0 l. O2/kg.hr at 2 months of age. 2. The contributions of shivering and non-shivering thermogenesis to these changes were estimated by three independent methods; non-shivering thermogenesis was stimulated by catecholamines in a thermoneutral environment, shivering was suppressed by curariform drugs during summit metabolism, and an attempt was made to suppress non-shivering thermogenesis during summit metabolism by use of the sympatholytic drugs phentolamine and propranolol. Drugs were given by intravenous infusion during measurement of oxygen consumption in a closed circuit respiration chamber. 3. `Resting' metabolic rate of lambs during the first day of life was increased two to three-fold, from 1 l. O2/kg.hr, by either adrenaline or noradrenaline infused at 1-10 μg/kg.min. The increase declined with increasing age of lamb and was virtually absent by 3 weeks. The response to catecholamines appeared maximal at the dose levels used. 4. Muscular paralysis induced by suxamethonium or gallamine reduced summit metabolism by about 2 l. O2/kg.hr in all lambs examined within the first 2 months of life. The residual metabolic rate, and the metabolic response to catecholamines under thermoneutral conditions, declined with age in the same manner, and their magnitudes were similar. 5. Summit metabolism in lambs aged up to 2 months was depressed to varying degrees by the sympathetic inhibitors phentolamine, propranolol and hexamethonium. The depression with propranolol was greater, and the decline with age clearer, than with phentolamine. Hexamethonium and phentolamine depressed blood pressure, propranolol decreased heart rate and phentolamine and propranolol each suppressed shivering in some experiments. 6. In 1 day-old lambs estimates of non-shivering thermogenesis, by the various methods, ranged from 0·8 to 1·4 l. O2/kg.hr (mean 1·1 l. or 31% of summit

  14. Dr. Hans Rosling, Keynote - 2013 ARPA-E Energy Innovation Summit

    ScienceCinema

    Rosling, Hans (Professor, International Health, Karolinska Institute; Edutainer, Gapminder.org)

    2016-07-12

    The fourth annual ARPA-E Energy Innovation Summit was held in Washington D.C. in February, 2013. The event brought together key players from across the energy ecosystem - researchers, entrepreneurs, investors, corporate executives, and government officials - to share ideas for developing and deploying the next generation of energy technologies. Dr. Hans Rosling (Professor, International Health, Karolinska Institute; Edutainer, Gapminder.org), gave this keynote address.

  15. 2012 ARPA-E Energy Innovation Summit Keynote Presentation (Susan Hockfield, MIT)

    ScienceCinema

    Hockfield, Susan (President, Massachusetts Institute of Technology)

    2016-07-12

    The third annual ARPA-E Energy Innovation Summit was held in Washington D.C. in February, 2012. The event brought together key players from across the energy ecosystem - reseachers, entrepeneurs, investors, corporate executives, and government officials - to share ideas for developing and deploying the next generation of energy technologies. Susan Hockfield, President of the Massachusetts Institute of Technology, gave the first keynote address of the third day's sessions on February 29.

  16. 2012 ARPA-E Energy Innovation Summit Keynote Presentation (Susan Hockfield, MIT)

    SciTech Connect

    Hockfield, Susan

    2012-02-29

    The third annual ARPA-E Energy Innovation Summit was held in Washington D.C. in February, 2012. The event brought together key players from across the energy ecosystem - reseachers, entrepeneurs, investors, corporate executives, and government officials - to share ideas for developing and deploying the next generation of energy technologies. Susan Hockfield, President of the Massachusetts Institute of Technology, gave the first keynote address of the third day's sessions on February 29.

  17. 2012 ARPA-E Energy Innovation Summit Keynote Presentation (Ursula Burns, Xerox Corporation)

    ScienceCinema

    Burns, Ursula (Xerox Corporation, Chairman and CEO)

    2016-07-12

    The third annual ARPA-E Energy Innovation Summit was held in Washington D.C. in February, 2012. The event brought together key players from across the energy ecosystem - researchers, entrepreneurs, investors, corporate executives, and government officials - to share ideas for developing and deploying the next generation of energy technologies. Ursula Burns, Chairman and CEO of the Xerox Corporation, gave the second keynote address of the third day's sessions on February 29.

  18. Strategic Research Institute G-Protein-Coupled Receptors Drug Discovery World Summit.

    PubMed

    Felder, Christian C

    2004-08-01

    The Strategic Research Institute provided a well-organised 2-day summit that offered presentations and posters on new assay technology, structure-based small-molecule discovery and examples of clinical candidates targeted to G-protein-coupled receptor (GPCR) targets. A wide variety of topics were presented providing recent advances in GPCR target selection, bioassay-enabling technology and medicinal chemistry targeted to GPCR-relevant chemical libraries. GPCRs continue to be an attractive platform for drug discovery.

  19. Dr. Hans Rosling, Keynote - 2013 ARPA-E Energy Innovation Summit

    SciTech Connect

    Rosling, Hans

    2014-03-06

    The fourth annual ARPA-E Energy Innovation Summit was held in Washington D.C. in February, 2013. The event brought together key players from across the energy ecosystem - researchers, entrepreneurs, investors, corporate executives, and government officials - to share ideas for developing and deploying the next generation of energy technologies. Dr. Hans Rosling (Professor, International Health, Karolinska Institute; Edutainer, Gapminder.org), gave this keynote address.

  20. Seismic detection of the summit magma complex of kilauea volcano, hawaii.

    PubMed

    Thurber, C H

    1984-01-13

    Application of simultaneous inversion of seismic P-wave arrival time data to the investigation of the crust beneath Kilauea Volcano yields a detailed picture of the volcano's heterogeneous structure. Zones of anomalously high seismic velocity are found associated with the volcano's rift zones. A low-velocity zone at shallow depth directly beneath the caldera coincides with an aseismic region interpreted as being the locus of Kilauea's summit magma complex.

  1. UN system machinery for coordinating follow-up to the World Food Summit.

    PubMed

    1997-12-01

    FAO [UN Food and Agriculture Organization] does not stand alone in implementing and monitoring the Summit Plan of Action. Commitments 7.2 and 7.3 give responsibility to the UN's Administrative Committee on Coordination (ACC) for coordinating interagency follow-up and to the Economic and Social Committee (ECOSOC) for receiving progress reports from FAO and other agencies. The UN General Assembly in December 1996 welcomed the outcome of the Summit and received FAO's first report on it at its 1997 session. The ACC has launched interagency follow-up by establishing the ACC Network on Rural Development and Food Security, as proposed jointly by FAO and the International Fund for Agricultural Development (IFAD). More than 16 UN agencies have joined and the UN Secretary-General has welcomed the intention to involve civil society and the emphasis placed on country-level action in the two-tiered network. All FAO country representatives and UN resident coordinators have been asked to help in setting up interagency thematic groups on rural development and food security at the country level. FAO has introduced a website for the network within SD Dimensions (http://www.fao.org/waicent/faoinfo/sustdev). ECOSOC has welcomed the ACC's decision to include follow-up to the World Food Summit within the context of the integrated follow-up process of all major UN conferences and summits. With these decisions, the machinery has been set in motion for early and sustained support from both interagency and intergovernmental bodies to national efforts to implement the Plan of Action.

  2. Catheter Ablation of Ventricular Arrhythmias Arising from the Left Ventricular Summit.

    PubMed

    Santangeli, Pasquale; Lin, David; Marchlinski, Francis E

    2016-03-01

    The left ventricular summit is a common site of origin of idiopathic ventricular arrhythmias. These arrhythmias are most commonly ablated within the coronary venous system or from other adjacent structures, such as the right ventricular and left ventricular outflow tract or coronary cusp region. When ablation from adjacent structures fails, a percutaneous epicardial approach can be considered, but is rarely successful in eliminating the arrhythmias due to proximity to major coronary vessels and/or epicardial fat.

  3. Participants in the First Florida Summit at the KSC Visitor Complex.

    NASA Technical Reports Server (NTRS)

    2000-01-01

    During the First Florida Space Summit, held at the Kennedy Space Center Visitor Complex, NASA Administrator Dan Goldin and Florida Gov. Jeb Bush pose for a photo. The event, featuring a discussion on the future of space as it relates to the State of Florida and moderated by Center Director Roy Bridges, included other participants such as Senator Bob Graham, Rep. Dave Weldon, 45th Space Wing Commander Brig. Gen. Donald Pettit and heads of aerospace companies.

  4. Participants in the First Florida Summit at the KSC Visitor Complex.

    NASA Technical Reports Server (NTRS)

    2000-01-01

    Senator Connie Mack (left) NASA Administrator Dan Goldin (right) are two of the participants in the First Florida Space Summit, held at the Kennedy Space Center Visitor Complex. The event, featuring a discussion on the future of space as it relates to the State of Florida and moderated by Center Director Roy Bridges, included other participants such as Senator Bob Graham, Rep. Dave Weldon, 45th Space Wing Commander Brig. Gen. Donald Pettit and heads of aerospace companies.

  5. Participants in the First Florida Summit at the KSC Visitor Complex.

    NASA Technical Reports Server (NTRS)

    2000-01-01

    Senator Bob Graham (left) and NASA Administrator Dan Goldin (right) are two of the participants in the First Florida Space Summit, held at the Kennedy Space Center Visitor Complex. The event, featuring a discussion on the future of space as it relates to the State of Florida and moderated by Center Director Roy Bridges, included other participants such as Senator Connie Mack, Rep. Dave Weldon, 45th Space Wing Commander Brig. Gen. Donald Pettit and heads of aerospace companies.

  6. Participants in the First Florida Summit at the KSC Visitor Complex.

    NASA Technical Reports Server (NTRS)

    2000-01-01

    Taking part in the First Florida Space Summit on the future of space as it relates to the State of Florida are (left to right) Lt. Governor Frank Brogan, 45th Space Wing Commander Brig. Gen. Donald Pettit, and Center Director Roy Bridges, who moderated the discussion. The event, held at the Kennedy Space Center Visitor Complex, also included Senator Bob Graham, Senator Connie Mack, State Senator Patsy Kurth, Representative Dave Weldon, and heads of aerospace companies.

  7. The First Physical Therapy Summit on Global Health: implications and recommendations for the 21st century.

    PubMed

    Dean, Elizabeth; Al-Obaidi, Saud; De Andrade, Armele Dornelas; Gosselink, Rik; Umerah, Gloria; Al-Abdelwahab, Sami; Anthony, Joseph; Bhise, Anjali R; Bruno, Selma; Butcher, Scotty; Fagevik-Olsén, Monika; Frownfelter, Donna; Gappmaier, Eduard; Gylfadóttir, Sif; Habibi, Mehrdad; Hanekom, Susan; Hasson, Scott; Jones, Alice; LaPier, Tanya; Lomi, Constantina; Mackay, Liz; Mathur, Sunita; O'Donoghue, Grainne; Playford, Kristen; Ravindra, Savita; Sangroula, Kanchan; Scherer, Susan; Skinner, Margot; Wong, Wai Pong

    2011-11-01

    The First Physical Therapy Summit on Global Health was convened at the 2007 World Confederation for Physical Therapy (WCPT) Congress to vision practice in the 21st century and, in turn, entry-level education and research, as informed by epidemiological indicators, and consistent with evidence-based noninvasive interventions, the hallmark of physical therapy. The Summit and its findings were informed by WHO data and validated through national databases of the countries of the five WCPT regions. The health priorities based on mortality were examined in relation to proportions of physical therapists practicing in the areas of regional priorities and of the curricula in entry-level programs. As a validation check and to contextualize the findings, input from members of the 800 Summit participants was integrated and international consultants refined the recommendations. Lifestyle-related conditions (ischemic heart disease, smoking-related conditions, hypertension, stroke, cancer, and diabetes) were leading causes of premature death across regions. Contemporary definitions of physical therapy support that the profession has a leading role in preventing, reversing, as well as managing lifestyle-related conditions. The proportions of practitioners practicing primarily in these priority areas and of the entry-level curricula based on these priorities were low. The proportions of practitioners in priority areas and entry-level curricula devoted to lifestyle-related conditions warrant being better aligned with the prevalence of these conditions across regions in the 21st century. A focus on clinical competencies associated with effective health education and health behavior change formulates the basis for The Second Physical Therapy Summit on Global Health.

  8. Participants in the First Florida Summit at the KSC Visitor Complex.

    NASA Technical Reports Server (NTRS)

    2000-01-01

    Participants in the First Florida Space Summit take part in a discussion on the future of space as it relates to the State of Florida. Held at the Kennedy Space Center Visitor Complex, the discussion was moderated by Center Director Roy Bridges. Seated (left to right) are Senator Connie Mack, NASA Administrator, Governor Jeb Bush, Senator Bob Graham and Representative Dave Weldon. The event also included 45th Space Wing Commander Brig. Gen. Donald Pettit and heads of aerospace companies.

  9. A CATALOG OF CH{sub 3}OH 7{sub 0}-6{sub 1} A {sup +} MASER SOURCES IN MASSIVE STAR-FORMING REGIONS. II. MASERS IN NGC 6334F, G8.67-0.36, AND M17

    SciTech Connect

    Gomez, Laura; Luis, Leticia; Hernandez-Curiel, Idalia; Kurtz, Stan E.; Hofner, Peter; Araya, Esteban D.

    2010-12-15

    We present Very Large Array (VLA) observations of the 7{sub 0}-6{sub 1} A {sup +} methanol maser transition at 44 GHz toward NGC 6334F, G8.67-0.36, and M17. These arcsecond resolution observations complete a previous, larger VLA survey of this maser transition in high-mass, star-forming regions reported by Kurtz et al. We confirm the presence of 44 GHz methanol maser emission in all 3 sources, detecting 8 distinct maser components in NGC 6334F, 12 components in G8.67-0.36, and 1 in M17.

  10. Blueprint for Action: Visioning Summit on the Future of the Workforce in Pediatrics.

    PubMed

    Sectish, Theodore C; Hay, William W; Mahan, John D; Mendoza, Fernando S; Spector, Nancy D; Stanton, Bonita; Szilagyi, Peter G; Turner, Teri L; Walker, Leslie R; Slaw, Kenneth

    2015-07-01

    The Federation of Pediatric Organizations engaged members of the pediatric community in an 18-month process to envision the future of the workforce in pediatrics, culminating in a Visioning Summit on the Future of the Workforce in Pediatrics. This article documents the planning process and methods used. Four working groups were based on the 4 domains that are likely to affect the future workforce: Child Health Research and Training, Diversity and Inclusion, Gender and Generations, and Pediatric Training Along the Continuum. These groups identified the issues and trends and prioritized their recommendations. Before the summit, 5 key megatrends cutting across all domains were identified:1. Aligning Education to the Emerging Health Needs of Children and Families 2. Promoting Future Support for Research Training and for Child Health Research 3. Striving Toward Mastery Within the Profession 4. Aligning and Optimizing Pediatric Practice in a Changing Health Care Delivery System 5. Taking Advantage of the Changing Demographics and Expertise of the Pediatric Workforce At the Visioning Summit, we assembled members of each of the working groups, the Federation of Pediatric Organizations Board of Directors, and several invited guests to discuss the 5 megatrends and develop the vision, solutions, and actions for each megatrend. Based on this discussion, we offer 10 recommendations for the field of pediatrics and its leading organizations to consider taking action.

  11. Emergency department operational metrics, measures and definitions: results of the Second Performance Measures and Benchmarking Summit.

    PubMed

    Welch, Shari J; Asplin, Brent R; Stone-Griffith, Suzanne; Davidson, Steven J; Augustine, James; Schuur, Jeremiah

    2011-07-01

    There is a growing mandate from the public, payers, hospitals, and Centers for Medicare & Medicaid Services (CMS) to measure and improve emergency department (ED) performance. This creates a compelling need for a standard set of definitions about the measurement of ED operational performance. This Concepts article reports the consensus of a summit of emergency medicine experts tasked with the review, expansion, and update of key definitions and metrics for ED operations. Thirty-two emergency medicine leaders convened for the Second Performance Measures and Benchmarking Summit on February 24, 2010. Before arrival, attendees were provided with the original definitions published in 2006 and were surveyed about gaps and limitations in the original work. According to survey responses, a work plan to revise and update the definitions was developed. Published definitions from key stakeholders in emergency medicine and health care were reviewed and circulated. At the summit, attendees discussed and debated key terminology and metrics and work groups were created to draft the revised document. Workgroups communicated online and by teleconference to reach consensus. When possible, definitions were aligned with performance measures and definitions put forth by the CMS, the Emergency Nurses Association Consistent Metrics Document, and the National Quality Forum. The results of this work are presented as a reference document.

  12. Petrological variability of recent magmatism at Axial Seamount summit, Juan de Fuca Ridge

    NASA Astrophysics Data System (ADS)

    Dreyer, Brian M.; Clague, David A.; Gill, James B.

    2013-10-01

    A combined study of mapping, observational, age constraint, and geochemical data at the summit of Axial Seamount, Juan de Fuca Ridge, has revealed its recent petrological history. Multiple basalt types erupted at the summit in a time sequence. At least three different magma batches have been present beneath the Axial Summit caldera during the last millennium, each with a range in differentiation. The first, prior to 1100 CE, was compositionally diverse, dominantly aphyric T-MORB. The second, from ˜1220 to 1300 CE, was dominantly plagioclase-phyric, more mafic N-MORB erupted mostly in the central portion of the caldera. Since ˜1400 CE, lavas have been more differentiated, and nearly aphyric T-MORB mostly erupted in the caldera's rift zones. Parental magmas vary subtly due to small coupled differences in the degree of melting and sources, but all share a uniform differentiation trend indicating pooling at similar depths. Thus, melts percolate through melt-rich lenses that remain partially isolated in space and/or time. Centennial magmatic timescales at Axial Seamount are similar to those for fast spreading ridge segments. The fluctuation between aphyric and plagioclase-phyric lava likely reflects different pathways or velocities of melt migration.

  13. Synoptic variability of clouds over Summit Station, Greenland: 2010-2012

    NASA Astrophysics Data System (ADS)

    Cox, C. J.; Walden, V. P.

    2012-12-01

    The Greenland Ice Sheet (GIS) is a large and unique feature in the Arctic. Long-term changes in the mass balance of the ice sheet, precipitation, runoff, and ice discharge have been observed on the GIS, along with recent extreme events such as the exceptional warm period and associated melting in July 2012. Clouds are important modulators of the surface energy budget and transporters of moisture; thus clouds influence these observations. Few measurements of clouds had been made over the GIS until the spring of 2010 when the Integrated Characterization of Energy, Clouds, Atmospheric state, and Precipitation at Summit (ICECAPS) atmospheric observatory began collecting data at Summit Station [72 N, 38 W, 3200 m]. ICECAPS observations of clouds and the atmosphere include those from an infrared spectrometer, lidar, radar, microwave radiometers, and radiosondes, among others. Brightness temperatures in cloud-sensitive microwindows from the ICECAPS infrared spectrometer, the Polar Atmospheric Emitted Radiance Interferometer (PAERI), and downwelling longwave fluxes are good indicators of cloud presence and cloud energy impact; thus, over time they are also good indicators of cloud variability. In this study, we examine these parameters to gain a more detailed understanding of the variability over Summit Station between spring 2010 and summer 2012, and how the variability might be connected to synoptic activity in the northern mid-latitudes. This information will be useful in evaluating model performance and in establishing a baseline for cloud temporal variability over the GIS.

  14. Methane anomalies in seawater above the Loihi submarine summit area, Hawaii

    SciTech Connect

    Gamo, Toshitaka; Ishibashi, Junichiro; Sakai, Hitoshi ); Tilbrook, B. )

    1987-10-01

    Hydrothermal activity above Loihi submarine volcano was characterized by water column distributions of methane, pH and helium-3. It was found that the southern Loihi summit is almost covered with hydrothermal plumes, which have anomalously high concentrations of methane (maximum: 569 {times} 10{sup {minus}6} cm{sup 3} kg{sup {minus}}1) accompanied by high concentrations of helium-3 and low pH values (minimum: 7.18). The plumes consist of two layers: a shallow plume (about 200 m above the summit) and a deep plume (about 100 m above the summit), probably derived from different hydrothermal vents. The shallow and deep plumes showed different CH{sub 4}/{sup 3}He and CH{sub 4}/pH ratios with the same {sup 3}He/pH ratio, which implies that methane concentrations differ between the hydrothermal end members for the two plumes. The variation of methane between the end members is suggested to result from inter-vent inhomogeneity of bacterial activities that consume or produce methane within the vents. Comparison of the CH{sub 4}/{sup 3}He ratios of the two plumes with the previous data for Loihi and other submarine hydrothermal areas confirms that the Loihi hotspot has one to two orders of magnitude smaller CH{sub 4}/{sup 3}He value than those of the East Pacific Rise and the Galapagos spreading centers.

  15. The Toxicology Education Summit: Building the Future of Toxicology Through Education

    PubMed Central

    Barchowsky, Aaron; Buckley, Lorrene A.; Carlson, Gary P.; Fitsanakis, Vanessa A.; Ford, Sue M.; Genter, Mary Beth; Germolec, Dori R.; Leavens, Teresa L.; Lehman-McKeeman, Lois D.; Safe, Stephen H.; Sulentic, Courtney E. W.; Eidemiller, Betty J.

    2012-01-01

    Toxicology and careers in toxicology, as well as many other scientific disciplines, are undergoing rapid and dramatic changes as new discoveries, technologies, and hazards advance at a blinding rate. There are new and ever increasing demands on toxicologists to keep pace with expanding global economies, highly fluid policy debates, and increasingly complex global threats to public health. These demands must be met with new paradigms for multidisciplinary, technologically complex, and collaborative approaches that require advanced and continuing education in toxicology and associated disciplines. This requires paradigm shifts in educational programs that support recruitment, development, and training of the modern toxicologist, as well as continued education and retraining of the midcareer professional to keep pace and sustain careers in industry, government, and academia. The Society of Toxicology convened the Toxicology Educational Summit to discuss the state of toxicology education and to strategically address educational needs and the sustained advancement of toxicology as a profession. The Summit focused on core issues of: building for the future of toxicology through educational programs; defining education and training needs; developing the “Total Toxicologist”; continued training and retraining toxicologists to sustain their careers; and, finally, supporting toxicology education and professional development. This report summarizes the outcomes of the Summit, presents examples of successful programs that advance toxicology education, and concludes with strategies that will insure the future of toxicology through advanced educational initiatives. PMID:22461448

  16. Proceedings of the inaugural International Summit for Medical Nutrition Education and Research.

    PubMed

    Laur, C; Ball, L; Ahankari, A S; Avdagovska, M; Crowley, J; Deen, D; Douglas, P; Hark, L; Kohlmeier, M; Luzi, L; McCotter, L; Martyn, K; Nowson, C; Wall, C; Ray, S

    2016-11-01

    Medical Nutrition Education (MNE) has been identified as an area with potential public health impact. Despite countries having distinctive education systems, barriers and facilitators to effective MNE are consistent across borders, demanding a common platform to initiate global programmes. A shared approach to supporting greater MNE is ideal to support countries to work together. In an effort to initiate this process, the Need for Nutrition Education/Innovation Programme group, in association with their strategic partners, hosted the inaugural International Summit on Medical Nutrition Education and Research on August 8, 2015 in Cambridge, UK. Speakers from the UK, the USA, Canada, Australia, New Zealand, Italy, and India provided insights into their respective countries including their education systems, inherent challenges, and potential solutions across two main themes: (1) Medical Nutrition Education, focused on best practice examples in competencies and assessment; and (2) Medical Nutrition Research, discussing how to translate nutrition research into education opportunities. The Summit identified shared needs across regions, showcased examples of transferrable strategies and identified opportunities for collaboration in nutrition education for healthcare (including medical) professionals. These proceedings highlight the key messages presented at the Summit and showcase opportunities for working together towards a common goal of improvement in MNE to improve public health at large.

  17. The Study to Understand Mortality and Morbidity in COPD (SUMMIT) study protocol.

    PubMed

    Vestbo, Jørgen; Anderson, Julie; Brook, Robert D; Calverley, Peter M A; Celli, Bartolome R; Crim, Courtney; Haumann, Brett; Martinez, Fernando J; Yates, Julie; Newby, David E

    2013-05-01

    Chronic obstructive pulmonary disease (COPD) often coexists with other chronic diseases and comorbidities that can markedly influence patients' health status and prognosis. This is particularly true for cardiovascular disease (CVD). However, there have been no trials assessing the effect of COPD medications on CVD in patients with both diseases. The "Study to Understand Mortality and Morbidity in COPD" (SUMMIT) aims at determining the impact of fluticasone furoate/vilanterol combination and the individual components on the survival of patients with moderate COPD and either a history of CVD or at increased risk for CVD. SUMMIT is a multicentre, randomised, double-blind, parallel-group, placebo-controlled trial of 16 000 patients with moderate COPD randomly assigned to once daily treatment with fluticasone furoate/vilanterol (100/25 μg), fluticasone furoate (100 μg), vilanterol (25 μg) or matched placebo; mortality is the primary end-point. The study is an event-driven trial powered by the comparison of furoate/vilanterol versus placebo. Secondary end-points are decline in forced expiratory volume in 1 s and effect on a composite cardiovascular end-point. This article describes the design of the SUMMIT study.

  18. Proceedings of the August 2011 Traceability Research Summit.

    PubMed

    Bhatt, Tejas; Buckley, Greg; McEntire, Jennifer C

    2013-12-01

    of data required to be maintained at value chain end points, and data privacy concerns. The third approach requires individual nodes within the value chain to maintain electronic records for its own data and make them available for querying during a traceback for outbreak investigation. The major advantage of this approach is the protection of confidential information and the potential for quicker access during a trace. However, the primary disadvantage of this approach is the need for greater computational power and a more complex mechanism to linking the value chain through the data. As next steps, a subgroup will work on clarifying the approach to meeting the goals of traceability, better defining critical tracking events, and articulating the strategy and return on investment from a regulatory and industry perspective. This will result in improved alignment of on-going traceability pilots and initiatives as well as a more actionable guidance document for public review.

  19. A Structural and Paleomagnetic Analysis of the Basalts of Summit Creek, central Cascades, Washington

    NASA Astrophysics Data System (ADS)

    Fetrow, A. C.; Valentine, M. J.

    2013-12-01

    This study is a detailed analysis of the structural geology and paleomagnetism of the Basalts of Summit Creek. Located southeast of Mount Rainier, this section of layered basaltic flows formed during the Eocene Epoch (55 to 45 Ma). During the Eocene, this region underwent a time of unique volcanism that has shaped the modern landscape of the Pacific Northwest. Over the course of the available field season, five excursions were taken into the field to conduct structural mapping and paleomagnetic core drilling. Although exposure is limited by vegetation, nineteen sites were mapped and ten of those were drilled for cores. Cores were analyzed using alternating field demagnetization and thermal demagnetization. Mapping data was integrated into a preliminary structural map of the section. This study attempts to provide a greater understanding of the emplacement and deformation of the Basalts of the Summit Creek and any possible relationship with the Crescent Basalts located in the Olympic Peninsula of Washington state. Once paleomagnetic directions were corrected for core orientation and bedding tilt, none of the flows yielded orientations consistent enough to provide reliable magnetic directions for the section. This scatter is believed to be due, in part, to hydrothermal alteration that has subsequently influenced the Basalts of the Summit Creek. The scattered magnetic orientations are quite similar to those observed in the Crescent Basalts. This is does not demonstrate a definite connection between the two chemically similar Eocene volcanic sequences, but it does provide another similarity on the growing list. The lava flows along the north, middle, and south of the area and, with a few exceptions, have a northeast strike and a northwest dip. Along the middle transect of the section, nearest to Pony Creek and Carleton Ridge, bedding orientation has greater variability and suggests that there may still be unidentified structures that are influencing the area. Reflected

  20. Possible origin and production pathway for BrO at Summit, Greenland

    NASA Astrophysics Data System (ADS)

    Haman, C.; Lefer, B. L.; Dibb, J. E.; Huey, G.; Stutz, J.; Liao, J.

    2009-12-01

    Previous studies have measured high levels of HO2 at Summit, Greenland, consistent with photochemical theory. However, OH levels at Summit were substantially elevated compared to steady state model simulations and previous measurements at the South Pole. The disagreement between measured and modeled OH was greatly accentuated during periods of high wind. A recent hypothesis suggests that halogen chemistry may be responsible for much of the observed disturbance in HOx partitioning at Summit. Adding bromine chemistry to the model suggests that as little as 10 pptv of BrO would drastically improve agreement between model and observations for both OH and HO2. During the 2007 and 2008 Summit GSHOX (Greenland Summit Halogen Experiment) field campaigns, BrO was measured using a long-path differential optical absorption spectroscopy (LP-DOAS) and a chemical ionization mass spectrometer (CIMS). Mixing ratios ranged from about 0 to 10 pptv with a mean of about 1.2 pptv. Two possible sources of BrO include local formation in the photochemically active snowpack and/or downward mixing from the free troposphere. An additional question concerns the origin of bromine to this remote site. High BrO events (greater than 5 pptv) occurred most often during high wind speeds (greater than 6 m/s) and a neutral temperature gradient. The unstable meteorological conditions and absence of a BrO diurnal cycle using a power spectrum analysis do not support local BrO formation in the photochemically active snowpack. FLEXPART backward trajectories and retroplume summaries show both marine boundary layer and stratospheric influences during the high BrO events. Positive potential vorticity anomalies and the increase of surface ozone and beryllium-7 suggest an upper troposphere/lower stratosphere intrusion. In addition, snow bromide increased drastically one or two days prior to most high BrO events. Possible sources of the bromide include advection from open leads in sea ice and downward mixing

  1. 3.5 Year Monitoring of 225 GHz Opacity at the Summit of Greenland

    NASA Astrophysics Data System (ADS)

    Matsushita, Satoki; Asada, Keiichi; Martin-Cocher, Pierre L.; Chen, Ming-Tang; Ho, Paul T. P.; Inoue, Makoto; Koch, Patrick M.; Paine, Scott N.; Turner, David D.

    2017-02-01

    We present the 3.5 years monitoring results of 225 GHz opacity at the summit of the Greenland ice sheet (Greenland Summit Camp) at an altitude of 3200 m using a tipping radiometer. We chose this site as our submillimeter telescope (Greenland Telescope) site, because conditions are expected to have low submillimeter opacity and because its location offers favorable baselines to existing submillimeter telescopes for global-scale Very Long Baseline Interferometry. The site shows a clear seasonal variation with the average opacity lower by a factor of two during winter. The 25%, 50%, and 75% quartiles of the 225 GHz opacity during the winter months of November through April are 0.046, 0.060, and 0.080, respectively. For the winter quartiles of 25% and 50%, the Greenland site is about 10%-30% worse than the Atacama Large Millimeter/submillimeter Array (ALMA) or the South Pole sites. Estimated atmospheric transmission spectra in winter season are similar to the ALMA site at lower frequencies (\\lt 450 GHz), which are transparent enough to perform astronomical observations almost all of the winter time with opacities \\lt 0.5, but 10%-25% higher opacities at higher frequencies (\\gt 450 GHz) than those at the ALMA site. This is due to the lower altitude of the Greenland site and the resulting higher line wing opacity from pressure-broadened saturated water lines in addition to higher dry air continuum absorption at higher frequencies. Nevertheless, half of the winter time at the Greenland Summit Camp can be used for astronomical observations at frequencies between 450 GHz and 1000 GHz with opacities \\lt 1.2, and 10% of the time show \\gt 10 % transmittance in the THz (1035 GHz, 1350 GHz, and 1500 GHz) windows. Summer season is good for observations at frequencies lower than 380 GHz. One major advantage of the Greenland Summit Camp site in winter is that there is no diurnal variation due to the polar night condition, and therefore the durations of low-opacity conditions

  2. Observational perspectives on cloud-atmosphere-surface coupling at Summit, Greenland

    NASA Astrophysics Data System (ADS)

    Cox, C. J.; Shupe, M.; Miller, N.; Noone, D.; Berkelhammer, M. B.; Raudzens Bailey, A.; O'Neill, M.; Persson, O. P. G.; Rowe, P. M.; Schneider, D. P.; Steen-Larsen, H. C.; Steffen, K.; Turner, D. D.; Walden, V. P.; White, J. W. C.

    2016-12-01

    The atmosphere modulates the surface mass and energy balances of the Greenland ice sheet, including the temperature of the snow and firn, thus facilitating surface melt. In the absence of clouds, infrared loss at the surface leads to the development of a stably-stratified boundary layer, which weakens turbulent mixing and limits surface mass loss through sublimation. This stable state is eroded by clouds, which are frequently observed throughout the year. Through precipitation clouds are a source of accumulation, but clouds also modify the surface energy budget substantially, providing an overall warming of the surface in all months (33 W m-2 annually) over the central plateau. Thus, variability in cloud cover can drive or facilitate many of the physical processes acting out at and near the surface. Here, recent research on the coupled surface-atmosphere dynamic, radiative, and mass relationships at Summit Station are discussed. The response of the surface energy and mass budgets to forcing caused by varying atmospheric and cloud conditions is quantified and contextualized with other Arctic locations. Some unique features of the Summit environment, such as its high elevation, low humidity, and seasonally persistent snow cover, are found to be important factors in the way that clouds and the atmosphere interact with the surface there compared to elsewhere. This work is supported by a recent critical mass of measurements pertaining to such interactions at Summit. Observations have been made by the Integrated Characterization of Energy, Clouds, Atmospheric state, and Precipitation at Summit (ICECAPS) program since 2010, including twice-daily temperature and humidity profiles from radiosoundings and cloud properties acquired from measurements made by lidar, radar, and passive spectral infrared and microwave radiometers. These measurements complement those of the surface radiation budget and meteorology made by the Swiss Federal Institute of Technology (ETH) and NOAA

  3. Draft Genome Sequences of Pseudomonas fluorescens Strains PA4C2 and PA3G8 and Pseudomonas putida PA14H7, Three Biocontrol Bacteria against Dickeya Phytopathogens

    PubMed Central

    Cigna, Jérémy; Raoul des Essarts, Yannick; Mondy, Samuel; Hélias, Valérie; Beury-Cirou, Amélie

    2015-01-01

    Pseudomonas fluorescens strains PA4C2 and PA3G8 and Pseudomonas putida strain PA14H7 were isolated from potato rhizosphere and show an ability to inhibit the growth of Dickeya phytopathogens. Here, we report their draft genome sequences, which provide a basis for understanding the molecular mechanisms involved in antibiosis against Dickeya. PMID:25635023

  4. A Meeting of Minds around Pedagogical Content Knowledge: Designing an International PCK Summit for Professional, Community, and Field Development

    ERIC Educational Resources Information Center

    Helms, Jenifer; Stokes, Laura

    2013-01-01

    A "conference" is a familiar mode of work for academics. Conferences provide opportunities to bring professionals working in a field together to share and build knowledge. As common as conferences are, however, they are quite challenging to design in ways that truly succeed in galvanizing the attention of an academic community on a…

  5. Postexercise peripheral oxygen saturation after completion of the 6-minute walk test predicts successfully reaching the summit of Aconcagua.

    PubMed

    Lazio, Matthew P; Van Roo, Jon D; Pesce, Carlos; Malik, Sanjeev; Courtney, D Mark

    2010-12-01

    The 6-minute walk test (6MWT) is a single measurement of functional status in patients with cardiovascular disease. It has not been studied at high altitude. We investigate the screening value of 6-minute walk distance (6MWD) and postexercise vital sign (VS) measurements as predictors of successfully reaching the summit or development of acute mountain sickness (AMS) on Aconcagua (6962 m). Prospective observational cohort in Aconcagua Provincial Park, Argentina. Adults climbing the normal route who registered with base camp physicians were included. There were no exclusion criteria. VSs were measured before (resting) and after (postexercise) completion of 6MWT while volunteers acclimatized at Plaza de Mulas base camp (4365 m). Volunteers proceeded towards the summit at their own pace and upon descent returned a questionnaire with maximum altitude reached and Lake Louise AMS Self-report Score (LLSelf). One hundred twenty-four volunteers completed the 6MWT. Sixty-four volunteers (51.6%) completed questionnaires; 56% summited. Median LLSelf was 4 (IQR: 3.0-6.5). There was no association between any resting or postexercise VS measurements and AMS. However, mean postexercise SpO(2) was 80.8% in summiters and 76.4% in nonsummiters, a difference of -4.4% (95% CI: -6.7 to -2.0, p = 0.0005). Postexercise SpO(2) < 75% had 97.2% sensitivity and negative likelihood ratio of 0.086 in predicting the outcome of successfully reaching the summit: only one climber with SpO(2) < 75% successfully reached the summit. This study provides the first published data on 6MWD recorded in the field at high altitude. Postexercise SpO(2) < 75% may be a useful screening test for predicting the outcome of successfully reaching the summit of Aconcagua. Copyright © 2010 Wilderness Medical Society. Published by Elsevier Inc. All rights reserved.

  6. Risk Determinants of Acute Mountain Sickness and Summit Success on a 6-Day Ascent of Mount Kilimanjaro (5895 m).

    PubMed

    Lawrence, James S; Reid, Stephen A

    2016-03-01

    The aims of this study were to assess incidence of acute mountain sickness (AMS) and summit success on a 6-day ascent profile of Mt. Kilimanjaro and evaluate potential risk factors for these outcomes. All trekkers through a single Australian tour company between August 2012 and July 2014 were included. Participants ascended via the Rongai route and attempted the summit on day 6. Daily assessments were made using the self-reported Lake Louise score (LLS) questionnaire. Two different AMS diagnostic criteria (LLS ≥ 3 and LLS ≥ 5) were used for data analysis. Risk factors for development of AMS and summit success were analyzed. Over the 24-month period a total of 175 participants undertook the trek. Incidence of AMS was 52.6% (LLS ≥ 3) and 22.9% (LLS ≥ 5). Summit success was 88%. Age, sex, body mass index, and acetazolamide use were not associated with risk of AMS development. Age ≥ 40 years (P = .0002) and female sex (P = .0004) were both significantly associated with reduced summit success rate. Our cohort found a lower incidence of AMS and better summit success on a 6-day ascent of Mt Kilimanjaro than previously described in other groups on 4- and 5-day ascents. Female sex and age ≥ 40 years both predicted failure to summit, but did not increase risk of developing AMS. AMS is a common cause of morbidity on Mt. Kilimanjaro, and although the risk can be mitigated by a slower ascent, there is an ongoing need for education of individual trekkers, tour companies, and local authorities. Copyright © 2016 Wilderness Medical Society. Published by Elsevier Inc. All rights reserved.

  7. Introduction to the Summit Session, "Leading Perspectives in Energy Research", from the Director of the DOE Office of Science, Bill Brinkman (2011 EFRC Summit)

    ScienceCinema

    Brinkman, Bill (Director, DOE Office of Science)

    2016-07-12

    In this video Bill Brinkman, Director of DOE's Office of Science, introduces the session, "Leading Perspectives in Energy Research," at the 2011 EFRC Summit and Forum. During the introduction of the senior representatives from both the public and private sector, Dr. Brinkman explained the motivation for creating the Energy Frontiers Research Centers program. The 2011 EFRC Summit and Forum brought together the EFRC community and science and policy leaders from universities, national laboratories, industry and government to discuss "Science for our Nation's Energy Future." In August 2009, the Office of Science established 46 Energy Frontier Research Centers. The EFRCs are collaborative research efforts intended to accelerate high-risk, high-reward fundamental research, the scientific basis for transformative energy technologies of the future. These Centers involve universities, national laboratories, nonprofit organizations, and for-profit firms, singly or in partnerships, selected by scientific peer review. They are funded at $2 to $5 million per year for a total planned DOE commitment of $777 million over the initial five-year award period, pending Congressional appropriations. These integrated, multi-investigator Centers are conducting fundamental research focusing on one or more of several “grand challenges” and use-inspired “basic research needs” recently identified in major strategic planning efforts by the scientific community. The purpose of the EFRCs is to integrate the talents and expertise of leading scientists in a setting designed to accelerate research that transforms the future of energy and the environment.

  8. Meeting Demand.

    ERIC Educational Resources Information Center

    Daneman, Kathy

    1998-01-01

    Addresses how a school district can use temporary classroom space to meet increasing student enrollment while additional space is being built. Provides examples of using portable facilities to supplement educational sites, including how to protect students who are in portable classrooms when tornadoes appear. (GR)

  9. The preservation of long-range transported nitrate in snow at Summit, Greenland (Invited)

    NASA Astrophysics Data System (ADS)

    Hastings, M. G.

    2013-12-01

    Nitrate is one of the major anions found in polar and alpine snow, both today and in the past. Deposition of nitrate to snow surfaces results from reactions of nitrogen oxides (NOx) with oxidants in the atmosphere, resulting in the production of HNO3 that is incorporated into precipitation or reacts on the surface of particles. Several factors motivate studying nitrate concentration in ice cores including reconstructing past levels of NOx, tropospheric oxidant concentrations and natural variability in NOx sources. The link between the atmospheric concentration of NOx and nitrate concentration in ice core records is problematic because post-depositional processing, such as photolysis and evaporation, can impact the concentration of nitrate in snow. Recent work has shown that the isotopic ratios of nitrate (15N/14N, 18O/16O, 17O/16O) can be a powerful tool for tracing post-depositional loss of nitrate from surface snow. The isotopic composition of nitrate has been shown to contain information about the source of the nitrate (i.e, NOx sources) and the oxidation processes that convert NOx to nitrate in the atmosphere prior to deposition. Results from a number of studies at Summit, Greenland reveal limited loss of nitrate from surface snow during highly photoactive periods, and the oxygen isotopic signatures in snow nitrate appear to be representative of atmospheric deposition of nitrate from outside of Summit. Higher than expected oxygen isotope ratios (18O/16O, 17O/16O) found in Summit summertime nitrate were expected to be dependent upon local photochemistry in which nitrate in the snow is photolyzed to NOx that is then oxidized above the snow by BrO to reform nitrate (i.e., BrONO2). However, the oxygen isotopic composition of nitrate collected at high time resolution in surface snow does not show any link to local gas phase concentrations of a number of species, including BrO. Furthermore, the combination of nitrogen and oxygen isotope data reveals interesting

  10. Analysis of nitrate in the snow and atmosphere at Summit, Greenland: Chemistry and transport

    NASA Astrophysics Data System (ADS)

    Fibiger, Dorothy L.; Dibb, Jack E.; Chen, Dexian; Thomas, Jennie L.; Burkhart, John F.; Huey, L. Gregory; Hastings, Meredith G.

    2016-05-01

    As a major sink of atmospheric nitrogen oxides (NOx = NO + NO2), nitrate (NO3-) in polar snow can reflect the long-range transport of NOx and related species (e.g., peroxyacetyl nitrate). On the other hand, because NO3- in snow can be photolyzed, potentially producing gas phase NOx locally, NO3- in snow (and thus, ice) may reflect local processes. Here we investigate the relationship between local atmospheric composition at Summit, Greenland (72°35'N, 38°25'W) and the isotopic composition of NO3- to determine the degree to which local processes influence atmospheric and snow NO3-. Based on snow and atmospheric observations during May-June 2010 and 2011, we find no connection between the local atmospheric concentrations of a suite of gases (BrO, NO, NOy, HNO3, and nitrite (NO2-)) and the NO3- isotopic composition or concentration in snow. This suggests that (1) the snow NO3- at Summit is primarily derived from long-range transport and (2) this NO3- is largely preserved in the snow. Additionally, three isotopically distinct NO3- sources were found to be contributing to the NO3- in the snow at Summit during both 2010 and 2011. Through the complete isotopic composition of NO3-, we suggest that these sources are local anthropogenic particulate NO3- from station activities (δ15N = 16‰, Δ17O = 4‰, and δ18O = 23‰), NO3- formed from midlatitude NOx (δ15N = -10‰, Δ17O = 29‰, δ18O = 78‰) and a NO3- source that is possibly influenced by or derived from stratospheric ozone NO3- (δ15N = 5‰, Δ17O = 39‰, δ18O = 100‰).

  11. Eliminating untimely deaths of women from heart disease: highlights from the Minnesota Women's Heart Summit.

    PubMed

    Lindquist, Ruth; Boucher, Jackie L; Grey, Elizabeth Zane; Cairns, Beth; Bobra, Shalini; Windenburg, Denise; Konety, Suma; Graham, Kevin; Luepker, Russell; Hayes, Sharonne N

    2012-01-01

    Despite national campaigns to increase awareness and reduce cardiovascular disease (CVD) mortality in women, CVD remains their leading cause of death, annually killing more women than men. Although some progress has been made in our understanding and treatment of CVD in women, the causes, extent, and demographic trends of observed sex differences and disparities remain uncertain, and the growing burden of CVD and its risk factors among younger women is concerning. The Minnesota Women's Heart Summit was convened to chart a course to eliminate premature deaths of women from heart disease. The multidisciplinary summit was hosted by the Minneapolis Heart Institute, Minneapolis Heart Institute Foundation, University of Minnesota, and Mayo Clinic. Presentations highlighted sex-based differences in symptoms, treatment, and outcomes, and panel experts provided commentary. Invited faculty and summit participants worked in small-group sessions to identify strategies to dissolve barriers, improve primary and secondary prevention, and enhance women's care and outcomes. This report summarizes strategies identified during the conference to serve as springboards for more substantive future initiatives. These include, for example, standardized data collection and use of existing data sets to inform perspectives on sex-related cardiovascular issues, mandatory reporting of sex-specific data, and increased attention to underserved/high-risk women. Participants acknowledged that implementing these ideas would be challenging and recommended key priorities/next action steps such as providing services close to "point-of-life" rather than "point-of-care" and creation of policies and regulations so that resources and environmental modifications encouraging healthier lifestyle choices are promoted. Additional research is needed to improve identification, treatment, and health behaviors and to address continued lack of awareness, symptom recognition delays, barriers to care, and outcome

  12. Greenland Ice Sheet Surface Elevation at Summit, Greenland: 2007-2013

    NASA Astrophysics Data System (ADS)

    Lutz, E.; Hawley, R. L.; Herring, T.

    2013-12-01

    Quantifying surface elevation change is essential for ice sheet mass balance estimates. We assessed surface elevation and elevation change of the Greenland Ice Sheet at a range of spatial scales using six years of monthly GPS surveys conducted near Summit between 8/2007 and 3/2013. The ~11 km route consists of 15 transects that run parallel and orthogonal to IceSat's groundtrack 412 and includes 121 repeat locations spatially distributed along the route (Figure 1). Horizontal velocities and velocity gradients derived from base station and transect positions agree closely with previous studies. At the survey scale, no significant linear elevation trend is evident over the study period. However, local- and transect-scale time series revealed significant elevation increases of 1--2 cm per year in the central and southern regions of the survey that spatially and temporally may correlate with wind transport events from Summit station. This finding illustrates how sample scale (e.g., density, location and extent) affects surface elevation estimates critical to remote sensing validation and mass balance estimation. Spectral time series analysis showed that the expected annual elevation cycle was dwarfed by a two-year periodicity that dominated nearly all time series. The elevation maximum of Winter 2012-2013 fell short of the expected elevation peak, possibly due to accelerated compaction forced by high temperatures in the preceding Summer of 2012. We also highlight spatial comparisons with elevation products from three NASA altimeters, including the Airborne Topographic Mapper (ATM), the Land, Vegetation, and Ice Sensor (LVIS), and the Multiple Altimeter Beam Experiment Lidar (MABEL). This unique long-term GPS dataset is valuable for assessing ice sheet elevation change at a range of spatial-temporal scales, and for validating remote sensing products. With continued effort this survey will provide invaluable ground-based observations linking ICESat, IceBridge and ICESat

  13. Evaluating the Impact of the Summit Station, Greenland Radiosonde Program on Data Modelers and Forecast Services

    NASA Astrophysics Data System (ADS)

    Martinez, C. J.; Starkweather, S.; Cox, C. J.; Solomon, A.; Shupe, M.

    2015-12-01

    Radiosondes are balloon-borne meteorological sensors used to acquire profiles of temperature and humidity. Radiosonde data are essential inputs for numerical weather prediction models and are used for climate research, particularly in the creation of reanalysis products. However, radiosonde programs are costly to maintain, in particular in the remote regions of the Arctic (e.g., $440,000/yr at Summit, Greenland), where only 40 of approximately 1000 routine global launches are made. The climate of this data-sparse region is poorly understood and forecast data assimilation procedures are designed for global applications. Thus, observations may be rejected from the data assimilation because they are too far from the model expectations. For the most cost-efficient deployment of resources and to improve forecasting methods, analyses of the effectiveness of individual radiosonde programs are necessary. Here, we evaluate how radiosondes launched twice daily (0 and 12 UTC) from Summit Station, Greenland, (72.58⁰N, 38.48⁰W, 3210 masl) influence the European Centre for Medium Range Weather Forecasting (ECMWF) operational forecasts from June 2013 through May of 2015. A statistical analysis is conducted to determine the impact of the observations on the forecast model and the meteorological regimes that the model fails to reproduce are identified. Assimilation rates in the inversion layer are lower than any other part of the troposphere. Above the inversion, assimilation rates range from 85%-100%, 60%-98%, and > 99% for temperature, humidity, and wind, respectively. The lowest assimilation rates are found near the surface, possibly associated with biases in the representation of the temperature inversion by the ECMWF model at Summit. Consequently, assimilation rates are lower near the surface during winter when strong temperature inversions are frequently observed. Our findings benefit the scientific community who uses this information for climatological analysis of the

  14. Measuring Snowfall at Summit, Greenland Using a Bistatic X-Band Radar

    NASA Astrophysics Data System (ADS)

    Castellani, B.; Shupe, M.

    2013-12-01

    With the current warming trend of the Earth's climate, the Greenland Ice Sheet (GIS) has been melting on its fringes and experiencing mass loss. However, the mass balance of the GIS as a whole is not well understood due to a deficiency of knowledge of the interior. Central to understanding this mass balance is precipitation, of which non-satellite derived observations over the central GIS are sparse. Here a conditional snowfall retrieval for the ground-based Precipitation Occurrence Sensor System (POSS), which is part of the Integrated Characterization of Energy, Clouds, Atmospheric state and Precipitation at Summit (ICECAPS) project in Greenland, is described. The conditional restraints for the POSS retrieval are based on qualitative ice particle habit information derived from relating periodic on-site ice crystal images to ranges of cloud base temperature derived from instantaneous lidar and interpolated radiosonde measurements. The snowfall from this habit-dependent retrieval is compared to various fixed-habit retrievals for the POSS, as well as other coinciding snowfall measurements taken at Summit by a vertical-pointing Ka-band cloud radar. Providing a broader perspective, this radar-based precipitation data is analyzed alongside weekly measurements from an accumulation forest, that includes a 10x10 grid of bamboo stakes that are used to measure the height change in the snow surface. In addition to snowfall, surface height changes include contributions from deposition, sublimation, melting, drifting, and compaction that must be accounted for. Using these three perspectives on snowfall, the annual cycle of precipitation at Summit, Greenland over the past three years is examined.

  15. Evaluating the Impact of the Summit Station, Greenland Radiosonde Program on Science and Forecast Services

    NASA Astrophysics Data System (ADS)

    Martinez, C. J.; Starkweather, S.; Cox, C. J.; Solomon, A.; Shupe, M.

    2015-12-01

    Radiosondes are balloon-borne meteorological sensors used to acquire profiles of temperature and humidity. Radiosonde data are essential inputs for numerical weather prediction models and are used for climate research, particularly in the creation of reanalysis products. However, radiosonde programs are costly to maintain, in particular in the remote regions of the Arctic (e.g., $440,000/yr at Summit, Greenland), where only 40 of approximately 1000 routine global launches are made. The climate of this data-sparse region is poorly understood and forecast data assimilation procedures are designed for global applications. Thus, observations may be rejected from the data assimilation because they are too far from the model expectations. For the most cost-efficient deployment of resources and to improve forecasting methods, analyses of the effectiveness of individual radiosonde programs are necessary. Here, we evaluate how radiosondes launched twice daily (0 and 12 UTC) from Summit Station, Greenland, (72.58⁰N, 38.48⁰W, 3210 masl) influence the European Centre for Medium Range Weather Forecasting (ECMWF) operational forecasts from June 2013 through May of 2015. A statistical analysis is conducted to determine the impact of the observations on the forecast model and the meteorological regimes that the model fails to reproduce are identified. Assimilation rates in the inversion layer are lower than any other part of the troposphere. Above the inversion, assimilation rates range from 85%-100%, 60%-98%, and > 99% for temperature, humidity, and wind, respectively. The lowest assimilation rates are found near the surface, possibly associated with biases in the representation of the temperature inversion by the ECMWF model at Summit. Consequently, assimilation rates are lower near the surface during winter when strong temperature inversions are frequently observed. Our findings benefit the scientific community who uses this information for climatological analysis of the

  16. Real geometry gyrokinetic PIC computations of ion turbulence in advanced tokamak discharges with SUMMIT/PG3EQ/NC

    NASA Astrophysics Data System (ADS)

    Leboeuf, Jean-Noel; Dimits, Andris; Shumaker, Dan

    2005-10-01

    Development of the PG3EQ/NC module within the SUMMIT gyrokinetic PIC FORTRAN 90 framework is largely completed. It provides SUMMIT with the capability of performing 3D nonlinear toroidal gyrokinetic computations of ion turbulence in real DIII-D geometry. PG3EQ/NC uses local, field line following, quasi-ballooning coordinates and direct interface with DIII-D equilibrium data via the EFIT and ONETWO codes. In addition, Holger Saint John's PLOTEQ code is used to determine the (r,z) position of each flux surface. The thus initialized SUMMIT computations have been carried out for shot /118561 at times 01450 and 02050 at many of the 51 flux surfaces from the core to the edge. Linear SUMMIT results will be compared to available data from calculations with the GKS code for the same discharges. Nonlinear SUMMIT results will also be compared with scattering measurements of turbulence, as well as with accessible measurements of fluctuation amplitudes and spectra from other diagnostics.

  17. Improved Design of Optical MEMS Using the SUMMiT Fabrication Process

    SciTech Connect

    Michalicek, M.A.; Comtois, J.H.; Barron, C.C.

    1997-12-31

    This paper describes the design and fabrication of optical Microelectromechanical Systems (MEMS) devices using the Sandia Ultra planar Multilevel MEMS Technology (SUMMiT) fabrication process. This state of the art process, offered by Sandia National Laboratories, provides unique and very advantageous features which make it ideal for optical devices. This enabling process permits the development of micromirror devices with near ideal characteristics which have previously been unrealizable in standard polysilicon processes. This paper describes such characteristics as elevated address electrodes, individual address wiring beneath the device, planarized mirror surfaces, unique post-process metallization, and the best active surface area to date.

  18. [3 summit conferences on Earth insufficient to save the Planet, Controversies and achievements].

    PubMed

    Pérez Pérez, Félix

    2003-01-01

    This review summarizes the present concerns on the deteriorated biological systems. This concern has generated many publications since it is a very serious subject. The human being has produced a deep impact on the environment that could even could induce climatic changes. Because these circumstances have increased the socioeconomical differences between developed and third world countries, the United Nations Organization had organized three summit conferences (Oslo, 1972; Rio do Janeiro, 1992; Johannesburgh, 2002) in order to propose solutions. This review discusses the conclusions held at these conferences.

  19. Quantifying the influence of halogens on nitrate photochemistry at Summit, Greenland

    NASA Astrophysics Data System (ADS)

    Fibiger, D.; Hastings, M. G.; Dibb, J. E.; Corr, C. A.; Huey, L. G.

    2011-12-01

    Concentrations of bromine oxide (BrO) >0.5 pptv have been detected regularly above the snowpack at Summit, Greenland [72°35'N, 38°25'W] during the spring and early summer. BrO often shows a diurnal cycle, with concentrations reaching as high as 10 pptv shortly after solar noon, although more typically found to be between 0.5 - 3.0 pptv. Our goal is to investigate the influence of BrO on the formation of nitrate (i.e. via BrONO2) based upon the oxygen isotopic composition of atmospheric and snow nitrate. Increased understanding of local nitrate post-depositional processing compared to transported nitrate will improve our ability to interpret nitrate in snow and ice core records. Deposition of nitrate results from reactions of NOx (NO and NO2) with oxidants in the atmosphere. The major oxidants in tropospheric nitrate formation, e.g. ozone (O3) and hydroxyl radical (OH), have distinctive isotopic compositions such that their relative contribution to NOx oxidation can be quantified based on Δ17O (Δ17O = δ17O - .52δ18O) of nitrate. In particular, O3 has a unique "mass independent fractionation" signature with Δ17O = 25-35% (per mil); BrO, formed from Br reacting with O3, is expected to carry a Δ17O = 30-42% (Morin et al., ACP, 2007); while OH has a Δ17O of 0%. Models of local photochemical post-depositional processing of NO3- utilizing the Δ17O of nitrate at Summit, Greenland cannot fully explain observed values (Kunasek et al., JGR, 2008; Jarvis et al., GRL, 2008). These O-D models do not include bromine chemistry. In a campaign consisting of two springtime (May-June) field seasons at Summit, Greenland, atmospheric and surface snow measurements were made to quantify the effect of bromine on the formation of atmospheric nitrate. Further, we look to use Δ17O of NO3- to investigate the influence of BrO on locally processed nitrate versus nitrate transported to Summit. Gas phase BrO, NO, NOy and soluble Br, NO3-, and NO2- were measured concurrently. In addition

  20. Sickle cell disease summit: from clinical and research disparity to action.

    PubMed

    Hassell, Kathryn; Pace, Betty; Wang, Winfred; Kulkarni, Roshni; Luban, Naomi; Johnson, Cage S; Eckman, James; Lane, Peter; Woods, William G

    2009-01-01

    The American Society of Pediatric Hematology/Oncology Sickle Cell Summit brought together a broad range of constituencies to identify a unified approach to healthcare and research disparities for sickle cell disease. Recommendations included the following: (1) speak with a unified voice representing all constituencies; (2) optimize access to care from knowledgeable health care providers and create a medical home for all individuals with the disease; (3) utilize population-based surveillance to measure outcomes; (4) develop overall approaches to basic, translational, clinical, and health services research; (5) enhance the community role in advocacy, education, service, and fundraising. Taskforces were identified to effect implementation.