NuSTAR Observation of a Type I X-Ray Burst from GRS 1741.9-2853

NASA Astrophysics Data System (ADS)

Barrière, Nicolas M.; Krivonos, Roman; Tomsick, John A.; Bachetti, Matteo; Boggs, Steven E.; Chakrabarty, Deepto; Christensen, Finn E.; Craig, William W.; Hailey, Charles J.; Harrison, Fiona A.; Hong, Jaesub; Mori, Kaya; Stern, Daniel; Zhang, William W.

2015-02-01

We report on two NuSTAR observations of GRS 1741.9-2853, a faint neutron star (NS) low-mass X-ray binary burster located 10' away from the Galactic center. NuSTAR detected the source serendipitously as it was emerging from quiescence: its luminosity was 6 × 1034 erg s-1 on 2013 July 31 and 5 × 1035 erg s-1 in a second observation on 2013 August 3. A bright, 800 s long, H-triggered mixed H/He thermonuclear Type I burst with mild photospheric radius expansion (PRE) was present during the second observation. Assuming that the luminosity during the PRE was at the Eddington level, an H mass fraction X = 0.7 in the atmosphere, and an NS mass M = 1.4 M ⊙, we determine a new lower limit on the distance for this source of 6.3 ± 0.5 kpc. Combining with previous upper limits, this places GRS 1741.9-2853 at a distance of 7 kpc. Energy independent (achromatic) variability is observed during the cooling of the NS, which could result from the disturbance of the inner accretion disk by the burst. The large dynamic range of this burst reveals a long power-law decay tail. We also detect, at a 95.6% confidence level (1.7σ), a narrow absorption line at 5.46 ± 0.10 keV during the PRE phase of the burst, reminiscent of the detection by Waki et al. We propose that the line, if real, is formed in the wind above the photosphere of the NS by a resonant Kα transition from H-like Cr gravitationally redshifted by a factor 1 + z = 1.09, corresponding to a radius range of 29.0-41.4 km for a mass range of 1.4-2.0 M ⊙.

NuSTAR OBSERVATION OF A TYPE I X-RAY BURST FROM GRS 1741.9-2853

DOE Office of Scientific and Technical Information (OSTI.GOV)

Barrière, Nicolas M.; Krivonos, Roman; Tomsick, John A.

We report on two NuSTAR observations of GRS 1741.9-2853, a faint neutron star (NS) low-mass X-ray binary burster located 10' away from the Galactic center. NuSTAR detected the source serendipitously as it was emerging from quiescence: its luminosity was 6 × 10{sup 34} erg s{sup –1} on 2013 July 31 and 5 × 10{sup 35} erg s{sup –1} in a second observation on 2013 August 3. A bright, 800 s long, H-triggered mixed H/He thermonuclear Type I burst with mild photospheric radius expansion (PRE) was present during the second observation. Assuming that the luminosity during the PRE was at the Eddington level, an H massmore » fraction X = 0.7 in the atmosphere, and an NS mass M = 1.4 M {sub ☉}, we determine a new lower limit on the distance for this source of 6.3 ± 0.5 kpc. Combining with previous upper limits, this places GRS 1741.9-2853 at a distance of 7 kpc. Energy independent (achromatic) variability is observed during the cooling of the NS, which could result from the disturbance of the inner accretion disk by the burst. The large dynamic range of this burst reveals a long power-law decay tail. We also detect, at a 95.6% confidence level (1.7σ), a narrow absorption line at 5.46 ± 0.10 keV during the PRE phase of the burst, reminiscent of the detection by Waki et al. We propose that the line, if real, is formed in the wind above the photosphere of the NS by a resonant Kα transition from H-like Cr gravitationally redshifted by a factor 1 + z = 1.09, corresponding to a radius range of 29.0-41.4 km for a mass range of 1.4-2.0 M {sub ☉}.« less

Three-Layered Atmospheric Structure in Accretion Disks Around Stellar-Mass Black Holes

NASA Technical Reports Server (NTRS)

Zhang, S. N.; Cui, Wei; Chen, Wan; Yao, Yangsen; Zhang, Xiaoling; Sun, Xuejun; Wu, Xue-Bing; Xu, Haiguang

2000-01-01

Modeling of the x-ray spectra of the Galactic superluminal jet sources GRS 1915+105 and GRO J1655-40 reveals a three-layered atmospheric structure in the inner region of the inner accretion disks. Above the cold and optically thick disk with a temperature of 0.2 to 0.5 kiloelectron volts, there is a warm layer with a temperature of 1.0 to 1.5 kiloelectron volts and an optical depth around 10. Sometimes there is also a much hotter, optically thin corona above the warm layer, with a temperature of 100 kiloelectron volts or higher and an optical depth around unity. The structural similarity between the accretion disks and the solar atmosphere suggests that similar physical processes may be operating in these different systems.

Three-layered atmospheric structure in accretion disks around stellar-mass black holes

PubMed

Zhang; Cui; Chen; Yao; Zhang; Sun; Wu; Xu

2000-02-18

Modeling of the x-ray spectra of the Galactic superluminal jet sources GRS 1915+105 and GRO J1655-40 reveals a three-layered atmospheric structure in the inner region of their accretion disks. Above the cold and optically thick disk with a temperature of 0.2 to 0.5 kiloelectron volts, there is a warm layer with a temperature of 1.0 to 1.5 kiloelectron volts and an optical depth around 10. Sometimes there is also a much hotter, optically thin corona above the warm layer, with a temperature of 100 kiloelectron volts or higher and an optical depth around unity. The structural similarity between the accretion disks and the solar atmosphere suggests that similar physical processes may be operating in these different systems.

The failed state transition of the ATOLL source GRS 1724-308

NASA Astrophysics Data System (ADS)

Tarana, A.; Capitanio, F.; Cocchi, M.

2018-07-01

The 2004-2012 X-ray time history of the NS LMXB GRS 1724-308 shows, along with the episodic brightenings associated with the low-high state transitions typical of the ATOLL sources, a peculiar, long lasting (˜300 d) flaring event, observed in 2008. This rare episode, characterized by a high-flux hard state, has never been observed before for GRS 1724-308, and in any case is not common among ATOLL sources. We discuss here different hypotheses on the origin of this peculiar event that displayed the spectral signatures of a failed transition, similar in shape and duration to those rarely observed in black hole binaries. We also suggest the possibility that the atypical flare occurred in coincidence with a new rising phase of the 12-yr superorbital modulation that has been previously reported by other authors. The analysed data also confirm for GRS 1724-308 the already reported orbital period of ˜90 d.

Determination of Black Hole Mass in Cyg X-1 by Scaling of Spectral Index-QPO Frequency Correlation

NASA Technical Reports Server (NTRS)

Shaposhnikov, Nickolai; Titarchuk, Lev

2007-01-01

It is well established that timing and spectral properties of Galactic Black Hole (BH) X-ray binaries (XRB) are strongly correlated. In particular, it has been shown that low frequency Quasi-Periodic Oscillation (QPO) nu(sub low) - photon index GAMMA correlation curves have a specific pattern. In a number of the sources studied the shape of the index-low frequency QPO correlations are self-similar with a position offset in the nu(sub low) - GAMMA plane determined by a BH mass M(sub BH). Specifically, Titarchuk & Fiorito (2004) gave strong theoretical and observational arguments that the QPO frequency values in this nu(sub low) - GAMMA correlation should be inversely proportional to M(sub BH). A simple translation of the correlation for a given source along frequency axis leads to the observed correlation for another source. As a result of this translation one can obtain a scaling factor which is simply a BH mass ratio for these particular sources. This property of the correlations offers a fundamentally new method for BH mass determination in XRBs. Here we use the observed QPO-index correlations observed in three BH sources: GRO J1655-40, GRS 1915+105 and Cyg X-1. The BH mass of (6.3 plus or minus 0.5) solar mass in GRO J1655-40 is obtained using optical observations. RXTE observations during the recent 2005 outburst yielded sufficient data to establish the correlation pattern during both rise and decay of the event. We use GRO J1655-40 as a standard reference source to measure the BH mass in Cyg X-1. We also revisit the GRS 1915+105 data as a further test of our scaling method. We obtain the BH mass in Cyg X-1 in the range 7.6-9.9.

Discovery of Photon Index Saturation in the Black Hole Binary GRS 1915+105

NASA Technical Reports Server (NTRS)

Titarchuk, Lev; Seifina, Elena

2009-01-01

We present a study of the correlations between spectral, timing properties and mass accretion rate observed in X-rays from the Galactic Black Hole (BH) binary GRS 1915+105 during the transition between hard and soft states. We analyze all transition episodes from this source observed with Rossi X-ray Timing Explorer (RXTE), coordinated with Ryle Radio Telescope (RT) observations. We show that broad-band energy spectra of GRS 1915+105 during all these spectral states can be adequately presented by two Bulk Motion Comptonization (BMC) components: a hard component (BMC1, photon index Gamma(sub 1) = 1.7 -- 3.0) with turnover at high energies and soft thermal component (BMC2, Gamma(sub 2) = 2.7 -- 4.2) with characteristic color temperature < or = 1 keV, and the red-skewed iron line (LAOR) component. We also present observable correlations between the index and the normalization of the disk "seed" component. The use of "seed" disk normalization, which is presumably proportional to mass accretion rate in the disk, is crucial to establish the index saturation effect during the transition to the soft state. We discovered the photon index saturation of the soft and hard spectral components at values of < or approximately equal 4.2 and 3 respectively. We present a physical model which explains the index-seed photon normalization correlations. We argue that the index saturation effect of the hard component (BMC1) is due to the soft photon Comptonization in the converging inflow close to 1311 and that of soft component is due to matter accumulation in the transition layer when mass accretion rate increases. Furthermore we demonstrate a strong correlation between equivalent width of the iron line and radio flux in GRS 1915+105. In addition to our spectral model components we also find a strong feature of "blackbody-like" bump which color temperature is about 4.5 keV in eight observations of the intermediate and soft states. We discuss a possible origin of this "blackbody-like" emission.

VizieR Online Data Catalog: Molecular clouds with GLIMPSE/MIPSGAL data (Retes-Romero+, 2017)

NASA Astrophysics Data System (ADS)

Retes-Romero, R.; Mayya, Y. D.; Luna, A.; Carrasco, L.

2017-11-01

All of the 12 selected molecular clouds have GLIMPSE and MIPSGAL public data available. Typical Spitzer RGB images (3.6um, 8.0um, and 24um) of the resulting sample of clouds are shown in Figure 1, where the position of the IRAS source is identified. In order to define the parent molecular cloud that harbors the high-mass star-forming regions, we used 13CO(J=1-0) emission data from the Galactic Ring Survey (GRS) database (Jackson+ 2006ApJS..163..145J). The survey data have a velocity resolution of 0.21km/s, a typical (1σ) rms sensitivity of ~0.13K, a main beam efficiency of {eta}mb=0.48, and a beam of 46". The 13CO emission spectra for the line of sight (LOS) to the selected IRAS sources are shown in Figure 2, where the observed velocity of the CS(J=2-1) emission line (Bronfman+ 1996, J/A+AS/115/81) is also marked. (3 data files).

Telescope performance and image simulations of the balloon-borne coded-mask protoMIRAX experiment

DOE Office of Scientific and Technical Information (OSTI.GOV)

Penacchioni, A. V., E-mail: ana.penacchioni@inpe.br; Braga, J., E-mail: joao.braga@inpe.br; Castro, M. A., E-mail: manuel.castro@inpe.br

2015-12-17

In this work we present the results of imaging simulations performed with the help of the GEANT4 package for the protoMIRAX hard X-ray balloon experiment. The instrumental background was simulated taking into account the various radiation components and their angular dependence, as well as a detailed mass model of the experiment. We modelled the meridian transits of the Crab Nebula and the Galactic Centre (CG) region during balloon flights in Brazil (∼ −23° of latitude and an altitude of ∼40 km) and introduced the correspondent spectra as inputs to the imaging simulations. We present images of the Crab and ofmore » three sources in the GC: 1E 1740.7-2942, GRS 1758-258 and GX 1+4. The results show that the protoMIRAX experiment is capable of making spectral and timing observations of bright hard X-ray sources as well as important imaging demonstrations that will contribute to the design of the MIRAX satellite mission.« less

Using machine learning to explore the long-term evolution of GRS 1915+105

NASA Astrophysics Data System (ADS)

Huppenkothen, Daniela; Heil, Lucy M.; Hogg, David W.; Mueller, Andreas

2017-04-01

Among the population of known Galactic black hole X-ray binaries, GRS 1915+105 stands out in multiple ways. It has been in continuous outburst since 1992, and has shown a wide range of different states that can be distinguished by their timing and spectral properties. These states, also observed in IGR J17091-3624, have in the past been linked to accretion dynamics. Here, we present the first comprehensive study into the long-term evolution of GRS 1915+105, using the entire data set observed with Rossi X-ray Timing Explorer over its 16-yr lifetime. We develop a set of descriptive features allowing for automatic separation of states, and show that supervised machine learning in the form of logistic regression and random forests can be used to efficiently classify the entire data set. For the first time, we explore the duty cycle and time evolution of states over the entire 16-yr time span, and find that the temporal distribution of states has likely changed over the span of the observations. We connect the machine classification with physical interpretations of the phenomenology in terms of chaotic and stochastic processes.

Real-time evolution of a large-scale relativistic jet

NASA Astrophysics Data System (ADS)

Martí, Josep; Luque-Escamilla, Pedro L.; Romero, Gustavo E.; Sánchez-Sutil, Juan R.; Muñoz-Arjonilla, Álvaro J.

2015-06-01

Context. Astrophysical jets are ubiquitous in the Universe on all scales, but their large-scale dynamics and evolution in time are hard to observe since they usually develop at a very slow pace. Aims: We aim to obtain the first observational proof of the expected large-scale evolution and interaction with the environment in an astrophysical jet. Only jets from microquasars offer a chance to witness the real-time, full-jet evolution within a human lifetime, since they combine a "short", few parsec length with relativistic velocities. Methods: The methodology of this work is based on a systematic recalibraton of interferometric radio observations of microquasars available in public archives. In particular, radio observations of the microquasar GRS 1758-258 over less than two decades have provided the most striking results. Results: Significant morphological variations in the extended jet structure of GRS 1758-258 are reported here that were previously missed. Its northern radio lobe underwent a major morphological variation that rendered the hotspot undetectable in 2001 and reappeared again in the following years. The reported changes confirm the Galactic nature of the source. We tentatively interpret them in terms of the growth of instabilities in the jet flow. There is also evidence of surrounding cocoon. These results can provide a testbed for models accounting for the evolution of jets and their interaction with the environment.

Long-Term Multiwavelength Observations of GRS 1758-258 and the Advection-dominated Accretion Flow Model

NASA Astrophysics Data System (ADS)

Keck, John W.; Craig, William W.; Hailey, Charles J.; Harrison, Fiona; Hong, Jae Sub; Kahn, Steven M.; Lubin, Philip M.; McLean, Ryan; Pivovaroff, Michael J.; Seiffert, Michael; Wurtz, Ron; Ziock, Klaus P.

2001-12-01

We present a long-term multiwavelength light curve of Galactic black hole candidate GRS 1758-258 by combining previously published and archival data from Granat, ROSAT, the Compton Gamma Ray Observatory, the Rossi X-Ray Timing Explorer, BeppoSAX, ASCA, EXOSAT, and the Very Large Array. In addition, we include the first spectral results from the balloon-borne Gamma-Ray Arcminute Telescope Imaging System (GRATIS). In light of divergent analyses of the 1991-1993 ROSAT observations, we have reanalyzed these data; we find that the soft X-rays track the hard X-rays and that the fits require no blackbody component-indicating that GRS 1758-258 did not go to the high state in 1993. We offer an interpretation of these long-baseline data based on the advection-dominated accretion flow (ADAF) model for a system with m<~mcrit. We find that the 1990-1993 coeval hard and soft X-ray observations support the ADAF predictions. We discuss a new way to constrain black hole mass with spectral data and the ADAF theory and apply this technique to GRS 1758-258 to find M1>~8-9 Msolar at an assumed distance of 8.5 kpc. Further investigations of the ADAF model allow us to evaluate the model critically against the 1996 data and flux-flux diagram of Barret, McClintock, & Grindlay and to understand the limits of the latter's ``X-ray burster box.''

International Conference: Milky Way Surveys: The Structure and Evolution of Our Galaxy

NASA Technical Reports Server (NTRS)

Clemens, Dan

2004-01-01

We were granted NASA support for partial sponsorship of an international conference on Galactic science, held June 15-17, 2003 and hosted by the Institute for Astrophysical Research at Boston University. This conference, entitled 'Milky Way Surveys: The Structure and Evolution of Our Galaxy' drew some 125 scientific experts, researchers, and graduate students to Boston to: (1) Present large area survey plans and findings; (2) Discuss important remaining questions and puzzles in Galactic science; and (3) To inform and excite students and researchers about the potential for using large area survey databases to address key Galactic science questions. An international Scientific Organizing Committee for this conference crafted a tightly packed two-day conference designed to highlight many recent and upcoming large area surveys (including 2MASS, SDSS, MSX, VLA-HI, GRS, and SIRTF/GLIMPSE) and current theoretical understandings and questions. By bringing together experts in the conduct of Galactic surveys and leading theorists, new ways of attacking long-standing scientific questions were encouraged. The titles of most of the talks and posters presented are attached to the end of this report.

Fast voltage-sensitive dye imaging of excitatory and inhibitory synaptic transmission in the rat granular retrosplenial cortex.

PubMed

Nixima, Ken'ichi; Okanoya, Kazuo; Ichinohe, Noritaka; Kurotani, Tohru

2017-09-01

Rodent granular retrosplenial cortex (GRS) has dense connections between the anterior thalamic nuclei (ATN) and hippocampal formation. GRS superficial pyramidal neurons exhibit distinctive late spiking (LS) firing property and form patchy clusters with prominent apical dendritic bundles. The aim of this study was to investigate spatiotemporal dynamics of signal transduction in the GRS induced by ATN afferent stimulation by using fast voltage-sensitive dye imaging in rat brain slices. In coronal slices, layer 1a stimulation, which presumably activated thalamic fibers, evoked propagation of excitatory synaptic signals from layers 2-4 to layers 5-6 in a direction perpendicular to the layer axis, followed by transverse signal propagation within each layer. In the presence of ionotropic glutamate receptor antagonists, inhibitory responses were observed in superficial layers, induced by direct activation of inhibitory interneurons in layer 1. In horizontal slices, excitatory signals in deep layers propagated transversely mainly from posterior to anterior via superficial layers. Cortical inhibitory responses upon layer 1a stimulation in horizontal slices were weaker than those in the coronal slices. Observed differences between coronal and horizontal planes suggest anisotropy of the intracortical circuitry. In conclusion, ATN inputs are processed differently in coronal and horizontal planes of the GRS and then conveyed to other cortical areas. In both planes, GRS superficial layers play an important role in signal propagation, which suggests that superficial neuronal cascade is crucial in the integration of multiple information sources. NEW & NOTEWORTHY Superficial neurons in the rat granular retrosplenial cortex (GRS) show distinctive late-spiking (LS) firing property. However, little is known about spatiotemporal dynamics of signal transduction in the GRS. We demonstrated LS neuron network relaying thalamic inputs to deep layers and anisotropic distribution of inhibition between coronal and horizontal planes. Since deep layers of the GRS receive inputs from the subiculum, GRS circuits may work as an integrator of multiple sources such as sensory and memory information. Copyright © 2017 the American Physiological Society.

Multi-Wavelength Monitoring of GRS 1915+105

NASA Technical Reports Server (NTRS)

Bandyopadhyay, R.; Martini, P.; Gerard, E.; Charles, P. A.; Wagner, R. M.; Shrader, C.; Shahbaz, T.; Mirabel, I. F.

1997-01-01

Since its discovery in 1992, the superluminal X-ray transient GRS 1915+105 has been extensively observed in an attempt to understand its behaviour. We present here first results from a multi-wavelength campaign undertaken from July to September 1996. This study includes X-ray data from the RXTE All Sky Monitor and BATSE, two-frequency data from the Nancay radio telescope, and infrared photometry from the 1.8 m Perkins telescope at Lowell Observatory. The first long-term well-sampled IR light curve of GRS 1915+105 is presented herein and is consistent with the interpretation of this source as a long-period binary. We compare the various light curves, searching for correlations in the behaviour of the source at differing wavelengths and for possible periodicities.

Different Types of X-Ray Bursts from GRS 1915+105 and Their Origin

NASA Astrophysics Data System (ADS)

Yadav, J. S.; Rao, A. R.; Agrawal, P. C.; Paul, B.; Seetha, S.; Kasturirangan, K.

1999-06-01

We report X-ray observations of the Galactic X-ray transient source GRS 1915+105 with the pointed proportional counters of the Indian X-ray Astronomy Experiment (IXAE) onboard the Indian satellite IRS-P3, which show remarkable richness in temporal variability. The observations were carried out on 1997 June 12-29 and August 7-10, in the energy range of 2-18 keV and revealed the presence of very intense X-ray bursts. All the observed bursts have a slow exponential rise, a sharp linear decay, and broadly can be put in two classes: irregular and quasi-regular bursts in one class, and regular bursts in the other. The regular bursts are found to have two distinct timescales and to persist over extended durations. There is a strong correlation between the preceding quiescent time and the burst duration for the quasi-regular and irregular bursts. No such correlation is found for the regular bursts. The ratio of average flux during the burst time to the average flux during the quiescent phase is high and variable for the quasi-regular and irregular bursts, while it is low and constant for the regular bursts. We present a comprehensive picture of the various types of bursts observed in GRS 1915+105 in the light of the recent theories of advective accretion disks. We suggest that the peculiar bursts that we have seen are characteristic of the change of state of the source. The source can switch back and forth between the low-hard state and the high-soft state near critical accretion rates in a very short timescale, giving rise to the irregular and quasi-regular bursts. The fast timescale for the transition of the state is explained by invoking the appearance and disappearance of the advective disk in its viscous timescale. The periodicity of the regular bursts is explained by matching the viscous timescale with the cooling timescale of the postshock region. A test of the model is presented using the publicly available 13-60 keV RXTE/PCA data for irregular and regular bursts concurrent with our observations. It is found that the 13-60 keV flux relative to the 2-13 keV flux shows clear evidence for state change between the quiescent phase and the burst phase. The value of this ratio during burst is consistent with the values observed during the high-soft state seen on 1997 August 19, while its value during quiescent phase is consistent with the values observed during the low-hard state seen on 1997 May 8.

Super-spinning compact objects and models of high-frequency quasi-periodic oscillations observed in Galactic microquasars

NASA Astrophysics Data System (ADS)

Kotrlová, Andrea; Török, Gabriel; Šrámková, Eva; Stuchlík, Zdeněk

2014-12-01

We have previously applied several models of high-frequency quasi-periodic oscillations (HF QPOs) to estimate the spin of the central Kerr black hole in the three Galactic microquasars, GRS 1915+105, GRO J1655-40, and XTE J1550-564. Here we explore the alternative possibility that the central compact body is a super-spinning object (or a naked singularity) with the external space-time described by Kerr geometry with a dimensionless spin parameter a ≡ cJ/GM2> 1. We calculate the relevant spin intervals for a subset of HF QPO models considered in the previous study. Our analysis indicates that for all but one of the considered models there exists at least one interval of a> 1 that is compatible with constraints given by the ranges of the central compact object mass independently estimated for the three sources. For most of the models, the inferred values of a are several times higher than the extreme Kerr black hole value a = 1. These values may be too high since the spin of superspinars is often assumed to rapidly decrease due to accretion when a ≫ 1. In this context, we conclude that only the epicyclic and the Keplerian resonance model provides estimates that are compatible with the expectation of just a small deviation from a = 1.

An unusually massive stellar black hole in the Galaxy.

PubMed

Greiner, J; Cuby, J G; McCaughrean, M J

2001-11-29

The X-ray source known as GRS1915+105 belongs to a group dubbed 'microquasars'. These objects are binary systems which sporadically eject matter at speeds that appear superluminal, as is the case for some quasars. GRS1915+105 is also one of only two known binary sources thought to contain a maximally spinning black hole. Determining the basic parameters of GRS195+105, such as the masses of the components, will help us to understand jet formation in this system, as well as providing links to other objects which exhibit jets. Using X-ray data, indirect methods have previously been used to infer a variety of masses for the accreting compact object in the range 10-30 solar masses (M middle dot in circle). Here we report a direct measurement of the orbital period and mass function of GRS1915+105, which allow us to deduce a mass of 14 +/- 4 M middle dot in circle for the black hole. Black holes with masses >5-7 M middle dot in circle challenge the conventional picture of black-hole formation in binary systems. Based on the mass estimate, we interpret the distinct X-ray variability of GRS1915+105 as arising from instabilities in an accretion disk that is dominated by radiation pressure, and radiating near the Eddington limit (the point where radiation pressure supports matter against gravity). Also, the mass estimate constrains most models which relate observable X-ray properties to the spin of black holes in microquasars.

Black hole spin inferred from 3:2 epicyclic resonance model of high-frequency quasi-periodic oscillations

NASA Astrophysics Data System (ADS)

Šrámková, E.; Török, G.; Kotrlová, A.; Bakala, P.; Abramowicz, M. A.; Stuchlík, Z.; Goluchová, K.; Kluźniak, W.

2015-06-01

Estimations of black hole spin in the three Galactic microquasars GRS 1915+105, GRO J1655-40, and XTE J1550-564 have been carried out based on spectral and timing X-ray measurements and various theoretical concepts. Among others, a non-linear resonance between axisymmetric epicyclic oscillation modes of an accretion disc around a Kerr black hole has been considered as a model for the observed high-frequency quasi-periodic oscillations (HF QPOs). Estimates of spin predicted by this model have been derived based on the geodesic approximation of the accreted fluid motion. Here we assume accretion flow described by the model of a pressure-supported torus and carry out related corrections to the mass-spin estimates. We find that for dimensionless black hole spin a ≡ cJ/GM2 ≲ 0.9, the resonant eigenfrequencies are very close to those calculated for the geodesic motion. Their values slightly grow with increasing torus thickness. These findings agree well with results of a previous study carried out in the pseudo-Newtonian approximation. The situation becomes different for a ≳ 0.9, in which case the resonant eigenfrequencies rapidly decrease as the torus thickness increases. We conclude that the assumed non-geodesic effects shift the lower limit of the spin, implied for the three microquasars by the epicyclic model and independently measured masses, from a ~ 0.7 to a ~ 0.6. Their consideration furthermore confirms compatibility of the model with the rapid spin of GRS 1915+105 and provides highly testable predictions of the QPO frequencies. Individual sources with a moderate spin (a ≲ 0.9) should exhibit a smaller spread of the measured 3:2 QPO frequencies than sources with a near-extreme spin (a ~ 1). This should be further examined using the large amount of high-resolution data expected to become available with the next generation of X-ray instruments, such as the proposed Large Observatory for X-ray Timing (LOFT).

Multi-Wavelength Monitoring of GRS 1915+105

NASA Technical Reports Server (NTRS)

Bandyopadhyay, R.; Martini, P.; Gerard, E.; Charles, P. A.; Wagner, R. M.; Shrader, C.; Shahbaz, T.; Mirabel, I. F.

1997-01-01

Since its discovery in 1992, the superluminal X-ray transient GRS 1915+105 has been extensively observed in an attempt to understand its behaviour. We present here preliminary results from a multi-wavelength campaign undertaken from July to September 1996. This study includes X-ray data from the RXTE All Sky Monitor and BATSE, two-frequency data from the Nancay radio telescope, and infrared photometry from the 1.8m Perkins telescope at Lowell Observatory. The K-band data presented herein provide the first long-term well-sampled IR light curve of GRS 1915+105. We compare the various light curves, searching for correlations in the behaviour of the source at differing wavelengths and for possible periodicities.

PRIMED: PRIMEr Database for Deleting and Tagging All Fission and Budding Yeast Genes Developed Using the Open-Source Genome Retrieval Script (GRS)

PubMed Central

Cummings, Michael T.; Joh, Richard I.; Motamedi, Mo

2015-01-01

The fission (Schizosaccharomyces pombe) and budding (Saccharomyces cerevisiae) yeasts have served as excellent models for many seminal discoveries in eukaryotic biology. In these organisms, genes are deleted or tagged easily by transforming cells with PCR-generated DNA inserts, flanked by short (50-100bp) regions of gene homology. These PCR reactions use especially designed long primers, which, in addition to the priming sites, carry homology for gene targeting. Primer design follows a fixed method but is tedious and time-consuming especially when done for a large number of genes. To automate this process, we developed the Python-based Genome Retrieval Script (GRS), an easily customizable open-source script for genome analysis. Using GRS, we created PRIMED, the complete PRIMEr D atabase for deleting and C-terminal tagging genes in the main S. pombe and five of the most commonly used S. cerevisiae strains. Because of the importance of noncoding RNAs (ncRNAs) in many biological processes, we also included the deletion primer set for these features in each genome. PRIMED are accurate and comprehensive and are provided as downloadable Excel files, removing the need for future primer design, especially for large-scale functional analyses. Furthermore, the open-source GRS can be used broadly to retrieve genome information from custom or other annotated genomes, thus providing a suitable platform for building other genomic tools by the yeast or other research communities. PMID:25643023

Disk-Wind Connection During the Heartbeats of GRS 1915+105

NASA Technical Reports Server (NTRS)

Zoghbi, Abderahmen; Miller, J. M.; King, A. L.; Miller, M. C.; Proga, D.; Kallman, T.; Fabian, A. C.; Harrison, F. A.; Kaastra, J.; Raymond, J.;

Disk-Wind Connection during the Heartbeats of GRS 1915+105

NASA Astrophysics Data System (ADS)

Zoghbi, Abderahmen; Miller, J. M.; King, A. L.; Miller, M. C.; Proga, D.; Kallman, T.; Fabian, A. C.; Harrison, F. A.; Kaastra, J.; Raymond, J.; Reynolds, C. S.; Boggs, S. E.; Christensen, F. E.; Craig, W.; Hailey, C. J.; Stern, D.; Zhang, W. W.

2016-12-01

Disk and wind signatures are seen in the soft state of Galactic black holes, while the jet is seen in the hard state. Here we study the disk-wind connection in the ρ class of variability in GRS 1915+105 using a joint NuSTAR-Chandra observation. The source shows 50 s limit cycle oscillations. By including new information provided by the reflection spectrum and using phase-resolved spectroscopy, we find that the change in the inner disk inferred from the blackbody emission is not matched by reflection measurements. The latter is almost constant, independent of the continuum model. The two radii are comparable only if the disk temperature color correction factor changes, an effect that could be due to the changing opacity of the disk caused by changes in metal abundances. The disk inclination is similar to that inferred from the jet axis, and oscillates by ˜10°. The simultaneous Chandra data show the presence of two wind components with velocities between 500 and 5000 km s-1, and possibly two more with velocities reaching 20,000 km s-1 (˜0.06 c). The column densities are ˜5 × 1022 cm-2. An upper limit to the wind response time of 2 s is measured, implying a launch radius of <6 × 1010 cm. The changes in wind velocity and absorbed flux require the geometry of the wind to change during the oscillations, constraining the wind to be launched from a distance of 290-1300 r g from the black hole. Both data sets support fundamental model predictions in which a bulge originates in the inner disk and moves outward as the instability progresses.

The Faint "Heartbeats" of IGR J17091-3624: An Exceptional Black Hole Candidate

NASA Technical Reports Server (NTRS)

Altamirano, D.; Belloni, T.; Linares, M.; VanDerKlis, M.; Wunands, R.; Curran, P. A.; Kalamkar, M.; Stiele, H.; Motta, S.; Munoz-Darias, T.;

Grs 1915+105: a superluminal source in the Galaxy.

PubMed Central

Rodríguez, L F; Mirabel, I F

1995-01-01

We present the results of additional observations of the high energy source GRS 1915+105, which produces ejecta with apparent superluminal motions. The observations reported here were carried out with the Very Large Array at 3.5 cm and 20 cm. The 3.5-cm observations made during 1994 May allowed us to continue following the proper motions of the bright 1994 March 19 ejecta, as well as those of a subsequent, fainter ejection. The proper motions of the 1994 March 19 ejecta continued to be ballistic (i.e., constant) over the period of about 75 days where they remained detectable. From the observations in 1994 March-May we have identified three ejections of pairs of plasma clouds moving ballistically in approximately the same direction on the sky with similar proper motions. The 20-cm observations made during 1994 November and December were used to search, yet unsuccessfully, for extended jets or lobes associated with GRS 1915+105. PMID:11607605

A New Outer Galaxy Molecular Cloud Catalog: Applications to Galactic Structure

NASA Astrophysics Data System (ADS)

Kerton, C. R.; Brunt, C. M.; Pomerleau, C.

2001-12-01

We have generated a new molecular cloud catalog from a reprocessed version of the Five College Radio Astronomy (FCRAO) Observatory Outer Galaxy Survey (OGS) of 12CO (J=1--0) emission. The catalog has been used to develop a technique that uses the observed angular size-linewidth relation (ASLWR) as a distance indicator to molecular cloud ensembles. The new technique is a promising means to map out the large-scale structure of our Galaxy using the new high spatial dynamic range CO surveys currently available. The catalog was created using a two-stage object-identification algorithm. We first identified contiguous emission structures of a specified minimum number of pixels above a specified temperature threshold. Each structure so defined was then examined and localized emission enhancements within each structure were identified as separate objects. The resulting cloud catalog, contains basic data on 14595 objects. From the OGS we identified twenty-three cloud ensembles. For each, bisector fits to angular size vs. linewidth plots were made. The fits vary in a systematic way that allows a calibration of the fit parameters with distance to be made. Our derived distances to the ensembles are consistent with the distance to the Perseus Arm, and the accurate radial velocity measurements available from the same data are in accord with the known non-circular motions at the location of the Perseus Arm. The ASLWR method was also successfully applied to data from the Boston University/FCRAO Galactic Ring Survey (GRS) of 13CO(J=1--0) emission. Based upon our experience with the GRS and OGS, the ASLWR technique should be usable in any data set with sufficient spatial dynamic range to allow it to be properly calibrated. C.P. participated in this study through the Women in Engineering and Science (WES) program of NRC Canada. The Dominion Radio Astrophysical Observatory is a National Facility operated by the National Research Council. The Canadian Galactic Plane Survey is a Canadian project with international partners, and is supported by the Natural Sciences and Engineering Research Council (NSERC).

V/V(max) test applied to SMM gamma-ray bursts

NASA Technical Reports Server (NTRS)

Matz, S. M.; Higdon, J. C.; Share, G. H.; Messina, D. C.; Iadicicco, A.

1992-01-01

We have applied the V/V(max) test to candidate gamma-ray bursts detected by the Gamma-Ray Spectrometer (GRS) aboard the SMM satellite to examine quantitatively the uniformity of the burst source population. For a sample of 132 candidate bursts identified in the GRS data by an automated search using a single uniform trigger criterion we find average V/V(max) = 0.40 +/- 0.025. This value is significantly different from 0.5, the average for a uniform distribution in space of the parent population of burst sources; however, the shape of the observed distribution of V/V(max) is unusual and our result conflicts with previous measurements. For these reasons we can currently draw no firm conclusion about the distribution of burst sources.

Mechanical design of the University of Florida Torsion Pendulum for testing the LISA Gravitational Reference Sensor

NASA Astrophysics Data System (ADS)

Shelley, Ryan; Chilton, Andrew; Olatunde, Tawio; Ciani, Giacomo; Mueller, Guido; Conklin, John

2014-03-01

The Laser Interferometer Space Antenna (LISA) requires free falling test masses, whose acceleration must be below 3 fm/s2/rtHz in the lower part of LISA's frequency band ranging from 0.1 to 100 mHz. Gravitational reference sensors (GRS) house the test masses, shield them from external disturbances, control their orientation, and sense their position at the nm/rtHz level. The GRS torsion pendulum is a laboratory test bed for GRS technology. By decoupling the system of test masses from the gravity of the Earth, it is possible to identify and quantify many sources of noise in the sensor. The mechanical design of the pendulum is critical to the study of the noise sources and the development of new technologies that can improve performance and reduce cost. The suspended test mass is a hollow, gold-coated, aluminum cube which rests inside a gold-coated, aluminum housing with electrodes for sensing and actuating all six degrees of freedom. This poster describes the design, analysis, and assembly of the mechanical subsystems of the UF Torsion Pendulum.

Gravitational Reference Sensor Technology Development at the University of Florida

NASA Astrophysics Data System (ADS)

Conklin, John; Chilton, Andrew; Chiani, Giacomo; Mueller, Guido; Shelley, Ryan

2013-04-01

The Laser Interferometer Space Antenna (LISA), the most mature concept for detecting gravitational waves from space, consists of three Sun-orbiting spacecraft that form a million kilometer-scale equilateral triangle. Each spacecraft houses two free-floating test masses (TM), which are protected from disturbing forces so that they follow pure geodesics. A single TM together with its protective housing and associated components is referred to as a gravitational reference sensor (GRS). Laser interferometry is used to measure the minute variations in the distance, or light travel time, between these purely free-falling TMs, caused by gravitational waves. The demanding acceleration noise requirement of 3 x 10-15 m/sec^2Hz^1/2 for the LISA GRS has motivated a rigorous testing campaign in Europe and a dedicated technology mission, LISA Pathfinder, scheduled for launch in 2014. In order to increase U.S. competency in GRS technologies, various research activities at the University of Florida (UF) have been initiated. The first is the development of a nearly thermally noise limited torsion pendulum for testing the GRS and for understanding the dozens of acceleration noise sources that affect the performance of the LISA GRS. The team at UF also collaborates with Stanford and NASA Ames on a small satellite mission that will test the performance of UV LEDs for ac charge control in space. This presentation will describe the design of the GRS testing facility at UF, the status of the UV LED small satellite mission, and plans for UF participation in the LISA Pathfinder mission.

QPO detection in superluminal black hole GRS 1915+105

NASA Astrophysics Data System (ADS)

Bhulla, Yashpal; Jaaffrey, S. N. A.

2018-05-01

We report on the first superluminal Black Hole GRS 1915+105 observed by the Rossi X-ray Timing Explorer - Proportion Counter Array (RXTE/PCA). We detect the Quasi Periodic Oscillations (QPOs) in the Power Density Spectrum (PDS) of source which have luminosity very near to Eddington limit and long variability in X-ray light curve. In power density spectrum, we deal with the study of highly variability amplitude, time evolution of the characteristic timescale, Quality Factor and Full Width at Half Maximum (FWHM). We find significant QPOs in 15 different observation IDs with frequency around 67 Hz although quality factor nearly 20 but in two IDs frequency is found just double. Typical fractional rms for GRS 1915+105 is dominating the hard band increasing steeply with energy more than 13% at 20-40 keV band.

The 2:3:6 quasi-periodic oscillation structure in GRS 1915+105 and cubic subharmonics in the context of relativistic discoseismology

NASA Astrophysics Data System (ADS)

Ortega-Rodríguez, M.; Solís-Sánchez, H.; López-Barquero, V.; Matamoros-Alvarado, B.; Venegas-Li, A.

2014-06-01

We propose a simple toy model to explain the 2:3:6 quasi-periodic oscillation (QPO) structure in GRS 1915+105 and, more generally, the 2:3 QPO structure in XTE J1550-564, GRO J1655-40 and H1743-322. The model exploits the onset of subharmonics in the context of discoseismology. We suggest that the observed frequencies may be the consequence of a resonance between a fundamental g mode and an unobservable p wave. The results include the prediction that, as better data become available, a QPO with a frequency of twice the higher twin frequency and a large quality factor will be observed in twin peak sources, as it might already have been observed in the especially active GRS 1915+105.

Observations of black hole candidate GRS 1758-258 by the GRATIS balloon-borne telescope and other observatories

NASA Astrophysics Data System (ADS)

Keck, John William

2001-08-01

The Gamma Ray Arcminute Telescope Imaging System (GRATIS) was flown from Alice Springs, Australia on October 17-18, 1995. The experiment consists of 35 individual one-dimensional coded-aperture telescopes with a field of view of 40 arcminutes in the imaging direction. We review the basic design of GRATIS, concentrating on the electronics critical to data acquisition. We survey the origins and types of background radiation that contaminate the data of GRATIS. We review previous work attempting to characterize the atmospheric gamma-ray background and combine the most dependable experimental results to model it. We calculate approximate magnitudes for all background components, and give the results of Monte Carlo simulations of the cosmic diffuse and atmospheric components using the COG radiation transport package. Finally, we combine GRATIS data with previously published and archival data from GRANAT, ROSAT, CGRO, RXTE, BeppoSAX, ASCA, and the VLA to produce a long-term multi-wavelength light curve of Galactic black hole candidate GRS 1758-258. In light of divergent analyses of the 1991-1993 ROSAT observations, we have re-analyzed these data; we find the soft x-rays track the hard x-rays, and that the fits require no black-body component-indicating that GRS 1758-258 did not go to the high state in 1993. We offer two standard corona-disk interpretations of the emission and an interpretation based on the ADAF model for a system with m˙ <~ m˙crit. We find the 1990-1993 co-eval hard and soft observations support the ADAF predictions. We discuss a new way to constrain black-hole mass with spectral data and the ADAF theory, and apply this technique to GRS 1758-258 to find MBH >~ 8-9 Msolar at an assumed distance of 8.5 kpc. Further investigations of the ADAF model allow us to critically evaluate the model against the data and flux- flux diagram of Barret, McClintock, & Grindlay (1996) and to understand the limits of the latter's ``X-ray burster box.''

Clinical Utility of Multimarker Genetic Risk Scores for Prediction of Incident Coronary Heart Disease: A Cohort Study Among Over 51 Thousand Individuals of European Ancestry.

PubMed

Iribarren, Carlos; Lu, Meng; Jorgenson, Eric; Martínez, Manuel; Lluis-Ganella, Carla; Subirana, Isaac; Salas, Eduardo; Elosua, Roberto

2016-12-01

We evaluated whether including multilocus genetic risk scores (GRSs) into the Framingham Risk Equation improves the predictive capacity, discrimination, and reclassification of asymptomatic individuals with respect to coronary heart disease (CHD) risk. We performed a cohort study among 51 954 European-ancestry members of a Northern California integrated healthcare system (67% female; mean age 59) free of CHD at baseline (2007-2008). Four GRSs were constructed using between 8 and 51 previously identified genetic variants. After a mean (±SD) follow-up of 5.9 (±1.5) years, 1864 incident CHD events were documented. All GRSs were linearly associated with CHD in a model adjusted by individual risk factors: hazard ratio (95% confidence interval) per SD unit: 1.21 (1.15-1.26) for GRS_8, 1.20 (1.15-1.26) for GRS_12, 1.23 (1.17-1.28) for GRS_36, and 1.23 (1.17-1.28) for GRS_51. Inclusion of the GRSs improved the C statistic (ΔC statistic =0.008 for GRS_8 and GRS_36; 0.007 for GRS_12; and 0.009 for GRS_51; all P<0.001). The net reclassification improvement was 5% for GRS_8, GRS_12, and GRS_36 and 4% for GRS_51 in the entire cohort and was (after correcting for bias) 9% for GRS_8 and GRS_12 and 7% for GRS_36 and GRS_51 when analyzing those classified as intermediate Framingham risk (10%-20%). The number required to treat to prevent 1 CHD after selectively treating with statins up-reclassified subjects on the basis of genetic information was 36 for GRS_8 and GRS_12, 41 for GRS_36, and 43 for GRS_51. Our results demonstrate significant and clinically relevant incremental discriminative/predictive capability of 4 multilocus GRSs for incident CHD among subjects of European ancestry. © 2016 American Heart Association, Inc.

Energy scaling of the "heartbeat" pulse width of GRS 1915+105, IGR J17091-3624, and MXB 1730-335 from Rossi-XTE observations

NASA Astrophysics Data System (ADS)

Maselli, A.; Capitanio, F.; Feroci, M.; Massa, F.; Massaro, E.; Mineo, T.

2018-04-01

We investigate some key aspects of the "heartbeat" variability consisting of series of bursts with a slow rise and a fast decay, thus far detected only in GRS 1915+105, IGR J17091-3624, and MXB 1730-335. A previous analysis based on BeppoSAX data of GRS 1915+105 revealed a hard-X delay (HXD), that is a lag of the burst rise at higher energies with respect to lower ones; this leads to narrower pulse widths, w, at higher energies. We here use some light curves of Rossi-XTE observations of GRS 1915+105 for a deeper analysis of this effect and search for its presence in those extracted from some IGR J17091-3624 and MXB 1730-335 observations performed with the same satellite. Our results show that, at variance with GRS 1915+105, no HXD is evident in the light curves of MXB 1730-335 and only a marginal HXD may be argued for IGR J17091-3624. For GRS 1915+105 we find a decreasing trend of the pulse width with energy following a power law w = A ṡ E-s with an index s ≈ 0.8. Furthermore, we confirm the increase of the HXD with the recurrence time Trec of the bursts in each series that was already found in previous works using BeppoSAX data. Based on a spectral analysis of these three sources we conclude that the differences highlighted in the properties of the "heartbeat" variability are probably related to the different accreting compact object and the eventual presence of a corona in these binary interacting systems.

X-ray spectral analysis of the steady states of GRS 1915+105

NASA Astrophysics Data System (ADS)

Peris, Charith; Remillard, Ronald A.; Steiner, James F.; Vrtilek, Saeqa Dil; Varniere, Peggy; Rodriguez, Jerome; Pooley, Guy G.

2016-04-01

Of the black hole binaries (BHBs) discovered thus far, GRS 1915+105 stands out as an exceptional source primarily due to its wild X-ray variability, the diversity of which has not been replicated in any other stellar-mass black hole. Although extreme variability is commonplace in its light-curve, about half of the observations of GRS1915+105 show fairly steady X-ray intensity. We report on the X-ray spectral behavior within these steady observations. Our work is based on a vast RXTE/PCA data set obtained on GRS 1915+105 during the course of its entire mission and 10 years of radio data from the Ryle Telescope, which overlap the X-ray data. We find that the steady observations within the X-ray data set naturally separate into two regions in a color-color diagram, which we refer to as steady-soft and steady-hard. GRS 1915+105 displays significant curvature in the Comptonization component within the PCA band pass suggesting significantly heating from a hot disk present in all states. A new Comptonization model 'simplcut' was developed in order to model this curvature to best effect. A majority of the steady-soft observations display a roughly constant inner disk radius, remarkably reminiscent of canonical soft state black hole binaries. In contrast, the steady-hard observations display a growing disk truncation that is correlated to the mass accretion rate through the disk, which suggests a magnetically truncated disk. A comparison of X-ray model parameters to the canonical state definitions show that almost all steady-soft observations match the criteria of either thermal or steep power law state, while the thermal state observations dominate the constant radius branch. A large portion 80 % of the steady-hard observations matches the hard state criteria when the disk fraction constraint is neglected. These results combine to suggest that within the complexity of this source is a simpler underlying basis of states, which map to those observed in canonical BHBs.

Accretion disk winds as the jet suppression mechanism in the microquasar GRS 1915+105.

PubMed

Neilsen, Joseph; Lee, Julia C

2009-03-26

Stellar-mass black holes with relativistic jets, also known as microquasars, mimic the behaviour of quasars and active galactic nuclei. Because timescales around stellar-mass black holes are orders of magnitude smaller than those around more distant supermassive black holes, microquasars are ideal nearby 'laboratories' for studying the evolution of accretion disks and jet formation in black-hole systems. Whereas studies of black holes have revealed a complex array of accretion activity, the mechanisms that trigger and suppress jet formation remain a mystery. Here we report the presence of a broad emission line in the faint, hard states and narrow absorption lines in the bright, soft states of the microquasar GRS 1915+105. ('Hard' and 'soft' denote the character of the emitted X-rays.) Because the hard states exhibit prominent radio jets, we argue that the broad emission line arises when the jet illuminates the inner accretion disk. The jet is weak or absent during the soft states, and we show that the absorption lines originate when the powerful radiation field around the black hole drives a hot wind off the accretion disk. Our analysis shows that this wind carries enough mass away from the disk to halt the flow of matter into the radio jet.

Inclination dependence of QPO phase lags in black hole X-ray binaries

NASA Astrophysics Data System (ADS)

van den Eijnden, J.; Ingram, A.; Uttley, P.; Motta, S. E.; Belloni, T. M.; Gardenier, D. W.

2017-01-01

Quasi-periodic oscillations (QPOs) with frequencies from ˜0.05to30 Hz are a common feature in the X-ray emission of accreting black hole binaries. As the QPOs originate from the innermost accretion flow, they provide the opportunity to probe the behaviour of matter in extreme gravity. In this paper, we present a systematic analysis of the inclination dependence of phase lags associated with both type-B and type-C QPOs in a sample of 15 Galactic black hole binaries. We find that the phase lag at the type-C QPO frequency strongly depends on inclination, both in evolution with the QPO frequency and sign. Although we find that the type-B QPO soft lags are associated with high-inclination sources, the source sample is too small to confirm that this as a significant inclination dependence. These results are consistent with a geometrical origin of type-C QPOs and a different origin for type-B and type-C QPOs. We discuss the possibility that the phase lags originate from a pivoting spectral power law during each QPO cycle, while the inclination dependence arises from differences in dominant relativistic effects. We also search for energy dependences in the type-C QPO frequency. We confirm this effect in the three known sources (GRS 1915+105, H1743-322 and XTE J1550-564) and newly detect it in XTE J1859+226. Lastly, our results indicate that the unknown inclination sources XTE J1859+226 and MAXI J1543-564 are most consistent with a high inclination.

Reinstating the M31 X-Ray System RX J0042.3+4115 as a Black Hole X-Ray Binary and Compelling Evidence for an Extended Corona

NASA Astrophysics Data System (ADS)

Barnard, R.; Garcia, M. R.; Murray, S. S.

2011-12-01

The M31 X-ray source RX J0042.3+4115 was originally identified as a black hole (BH) binary because it displayed characteristic low-state variability at conspicuously high luminosities; unfortunately, this variability was later found to be artificial. However, analysis of 84 Chandra ACIS observations, a Hubble Space Telescope Advanced Camera for Surveys (ACS)/WFC observation, and a 60 ks XMM-Newton observation has supplied new evidence that RX J0042.3+4115 is indeed a BH binary. The brightest optical star within 3σ of the position of RXJ0042.3+4115 had a F435W (~B) magnitude of 25.4 ± 0.2; M B > -0.4, hence we find a low-mass donor likely. RX J0042.3+4115 was persistently bright over ~12 years. Spectral fits revealed characteristic BH binary states: a low/hard state at 2.08 ± 0.08 × 1038 erg s-1 and a steep power-law state at 2.41 ± 0.05 × 1038 erg s-1 (0.3-10 keV). The high-luminosity low state suggests a ~20 M ⊙ primary; this is high, but within the range of known stellar BH masses. The inner disk temperature during the steep power-law state is 2.24 ± 0.15 keV, high but strikingly similar to that of GRS 1915+105, the only known Galactic BH binary with a low-mass donor to be persistently bright. Therefore, RX J0042.3+4115 may be an analog for GRS 1915+105; however, other mechanisms may account for its behavior. We find compelling evidence for an extended corona during the steep power-law state, because compact corona models where the seed photons for Comptonization are tied to the inner disk temperature are rejected.

Revelations of X-ray spectral analysis of the enigmatic black hole binary GRS 1915+105

NASA Astrophysics Data System (ADS)

Peris, Charith; Remillard, Ronald A.; Steiner, James; Vrtilek, Saeqa Dil; Varniere, Peggy; Rodriguez, Jerome; Pooley, Guy

2016-01-01

Of the black hole binaries discovered thus far, GRS 1915+105 stands out as an exceptional source primarily due to its wild X-ray variability, the diversity of which has not been replicated in any other stellar-mass black hole. Although extreme variability is commonplace in its light-curve, about half of the observations of GRS1915+105 show fairly steady X-ray intensity. We report on the X-ray spectral behavior within these steady observations. Our work is based on a vast RXTE/PCA data set obtained on GRS 1915+105 during the course of its entire mission and 10 years of radio data from the Ryle Telescope, which overlap the X-ray data. We find that the steady observations within the X-ray data set naturally separate into two regions in a color-color diagram, which we refer to as steady-soft and steady-hard. GRS 1915+105 displays significant curvature in the Comptonization component within the PCA band pass suggesting significantly heating from a hot disk present in all states. A new Comptonization model 'simplcut' was developed in order to model this curvature to best effect. A majority of the steady-soft observations display a roughly constant inner radius; remarkably reminiscent of canonical soft state black hole binaries. In contrast, the steady-hard observations display a growing disk truncation that is correlated to the mass accretion rate through the disk, which suggests a magnetically truncated disk. A comparison of X-ray model parameters to the canonical state definitions show that almost all steady-soft observations match the criteria of either thermal or steep power law state, while the thermal state observations dominate the constant radius branch. A large portion (80%) of the steady-hard observations matches the hard state criteria when the disk fraction constraint is neglected. These results suggest that within the complexity of this source is a simpler underlying basis of states, which map to those observed in canonical black hole binaries. When represented in a color-color diagram, state assignments appear to map to ``A, B and C'' (Belloni et al. 2000) regions that govern fast variability cycles in GRS 1915+105 demonstrating a compelling link between short and long time scales in its phenomenology.

Saccharomyces cerevisiae possesses a stress-inducible glycyl-tRNA synthetase gene.

PubMed

Chen, Shun-Jia; Wu, Yi-Hua; Huang, Hsiao-Yun; Wang, Chien-Chia

2012-01-01

Aminoacyl-tRNA synthetases are a large family of housekeeping enzymes that are pivotal in protein translation and other vital cellular processes. Saccharomyces cerevisiae possesses two distinct nuclear glycyl-tRNA synthetase (GlyRS) genes, GRS1 and GRS2. GRS1 encodes both cytoplasmic and mitochondrial activities, while GRS2 is essentially silent and dispensable under normal conditions. We herein present evidence that expression of GRS2 was drastically induced upon heat shock, ethanol or hydrogen peroxide addition, and high pH, while expression of GRS1 was somewhat repressed under those conditions. In addition, GlyRS2 (the enzyme encoded by GRS2) had a higher protein stability and a lower K(M) value for yeast tRNA(Gly) under heat shock conditions than under normal conditions. Moreover, GRS2 rescued the growth defect of a GRS1 knockout strain when highly expressed by a strong promoter at 37 °C, but not at the optimal temperature of 30 °C. These results suggest that GRS2 is actually an inducible gene that may function to rescue the activity of GRS1 under stress conditions.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Giacomini, Gabriele; Huber, Alan; Redus, Robert

We report that when an uncollimated radioactive X-ray source illuminates a silicon PIN sensor, some ionizing events are generated in the nonimplanted gap between the active area of the sensor and the guard rings (GRs). Carriers can be collected by floating electrodes, i.e., electron accumulation layers at the silicon/oxide interface, and floating GRs. The crosstalk signals generated by these events create spurious peaks, replicas of the main peaks at either lower amplitude or of opposite polarity. Lastly, we explain this phenomenon as crosstalk caused by charge collected on these floating electrodes, which can be analyzed by means of an extensionmore » of Ramo theorem.« less

A new torsion pendulum for testing enhancements to the LISA Gravitational Reference Sensor

NASA Astrophysics Data System (ADS)

Conklin, John; Chilton, A.; Ciani, G.; Mueller, G.; Olatunde, T.; Shelley, R.

2014-01-01

The Laser Interferometer Space Antenna (LISA), the most mature concept for observing gravitational waves from space, consists of three Sun-orbiting spacecraft that form a million km-scale equilateral triangle. Each spacecraft houses two free-floating test masses (TM), which are protected from disturbing forces so that they follow pure geodesics in spacetime. A single test mass together with its housing and associated components is referred to as a gravitational reference sensor (GRS). Laser interferometry is used to measure the minute variations in the distance between these free-falling TMs, caused by gravitational waves. The demanding acceleration noise requirement of 3E-15 m/sec^2Hz^1/2 for the LISA GRS has motivated a rigorous testing campaign in Europe and a dedicated technology mission, LISA Pathfinder, scheduled for launch in 2015. Recently, efforts have begun in the U.S. to design and assemble a new, nearly thermally noise limited torsion pendulum for testing GRS technology enhancements and for understanding the dozens of acceleration noise sources that affect the performance of the GRS. This experimental facility is based on the design of a similar facility at the University of Trento, and will consist of a vacuum enclosed torsion pendulum that suspends mock-ups of the LISA test masses, surrounded by electrode housings. The GRS technology enhancements under development include a novel TM charge control scheme based on ultraviolet LEDs, simplified capacitive readout electronics, and a six degree-of-freedom, all-optical TM sensor. This presentation will describe the design of the torsion pendulum facility, its expected performance, and the potential technology enhancements.

Internet Administration of the Paper-and-Pencil Gifted Rating Scale: Assessing Psychometric Equivalence

ERIC Educational Resources Information Center

Yarnell, Jordy B.; Pfeiffer, Steven I.

2015-01-01

The present study examined the psychometric equivalence of administering a computer-based version of the Gifted Rating Scale (GRS) compared with the traditional paper-and-pencil GRS-School Form (GRS-S). The GRS-S is a teacher-completed rating scale used in gifted assessment. The GRS-Electronic Form provides an alternative method of administering…

Polyacrylonitrile Fibers Anchored Cobalt/Graphene Sheet Nanocomposite: A Low-Cost, High-Performance and Reusable Catalyst for Hydrogen Generation.

PubMed

Zhang, Fei; Huang, Guoji; Hou, Chengyi; Wang, Hongzhi; Zhang, Qinghong; Li, Yaogang

2016-06-01

Cobalt and its composites are known to be active and inexpensive catalysts in sodium borohydride (NaBH4) hydrolysis to generate clean and renewable hydrogen energy. A novel fiber catalyst, cobalt/graphene sheet nanocomposite anchored on polyacrylonitrile fibers (Co/GRs-PANFs), which can be easily recycled and used in any reactor with different shapes, were synthesized by anchoring cobalt/graphene (Co/GRs) on polyacrylonitrile fibers coated with graphene (GRs-PANFs) at low temperature. The unique structure design effectively prevents the inter-sheet restacking of Co/GRs and fully exploits the large surface area of novel hybrid material for generate hydrogen. And the extra electron transfer path supplied by GRs on the surface of GRs-PANFs can also enhance their catalysis performances. The catalytic activity of the catalyst was investigated by the hydrolysis of NaBH4 in aqueous solution with GRs-PANFs. GRs powders and Co powders were used as control groups. It was found that both GRs and fiber contributed to the hydrogen generation rate of Co/GRs-PANFs (3222 mL x min(-1) x g(-1)), which is much higher than that of cobalt powders (915 mL x min(-1) x g(-1)) and Co/GRs (995 mL x min(-1) x g(-1)). The improved hydrogen generation rate, low cost and uncomplicated recycling make the Co/GRs-PANFs promising candidate as catalysts for hydrogen generation.

HIREGS observations of the Galactic center and Galactic plane: Separation of the diffuse Galactic hard X-ray continuum from the point source spectra

NASA Technical Reports Server (NTRS)

Boggs, S. E.; Lin, R. P.; Coburn, W.; Feffer, P.; Pelling, R. M.; Schroeder, P.; Slassi-Sennou, S.

1997-01-01

The balloon-borne high resolution gamma ray and X-ray germanium spectrometer (HIREGS) was used to observe the Galactic center and two positions along the Galactic plane from Antarctica in January 1995. For its flight, the collimators were configured to measure the Galactic diffuse hard X-ray continuum between 20 and 200 keV by directly measuring the point source contributions to the wide field of view flux for subtraction. The hard X-ray spectra of GX 1+4 and GRO J1655-40 were measured with the diffuse continuum subtracted off. The analysis technique for source separation is discussed and the preliminary separated spectra for these point sources and the Galactic diffuse emission are presented.

A graphically oriented specification language for automatic code generation. GRASP/Ada: A Graphical Representation of Algorithms, Structure, and Processes for Ada, phase 1

NASA Technical Reports Server (NTRS)

Cross, James H., II; Morrison, Kelly I.; May, Charles H., Jr.; Waddel, Kathryn C.

1989-01-01

The first phase of a three-phase effort to develop a new graphically oriented specification language which will facilitate the reverse engineering of Ada source code into graphical representations (GRs) as well as the automatic generation of Ada source code is described. A simplified view of the three phases of Graphical Representations for Algorithms, Structure, and Processes for Ada (GRASP/Ada) with respect to three basic classes of GRs is presented. Phase 1 concentrated on the derivation of an algorithmic diagram, the control structure diagram (CSD) (CRO88a) from Ada source code or Ada PDL. Phase 2 includes the generation of architectural and system level diagrams such as structure charts and data flow diagrams and should result in a requirements specification for a graphically oriented language able to support automatic code generation. Phase 3 will concentrate on the development of a prototype to demonstrate the feasibility of this new specification language.

Comparison of weighting approaches for genetic risk scores in gene-environment interaction studies.

PubMed

Hüls, Anke; Krämer, Ursula; Carlsten, Christopher; Schikowski, Tamara; Ickstadt, Katja; Schwender, Holger

2017-12-16

Weighted genetic risk scores (GRS), defined as weighted sums of risk alleles of single nucleotide polymorphisms (SNPs), are statistically powerful for detection gene-environment (GxE) interactions. To assign weights, the gold standard is to use external weights from an independent study. However, appropriate external weights are not always available. In such situations and in the presence of predominant marginal genetic effects, we have shown in a previous study that GRS with internal weights from marginal genetic effects ("GRS-marginal-internal") are a powerful and reliable alternative to single SNP approaches or the use of unweighted GRS. However, this approach might not be appropriate for detecting predominant interactions, i.e. interactions showing an effect stronger than the marginal genetic effect. In this paper, we present a weighting approach for such predominant interactions ("GRS-interaction-training") in which parts of the data are used to estimate the weights from the interaction terms and the remaining data are used to determine the GRS. We conducted a simulation study for the detection of GxE interactions in which we evaluated power, type I error and sign-misspecification. We compared this new weighting approach to the GRS-marginal-internal approach and to GRS with external weights. Our simulation study showed that in the absence of external weights and with predominant interaction effects, the highest power was reached with the GRS-interaction-training approach. If marginal genetic effects were predominant, the GRS-marginal-internal approach was more appropriate. Furthermore, the power to detect interactions reached by the GRS-interaction-training approach was only slightly lower than the power achieved by GRS with external weights. The power of the GRS-interaction-training approach was confirmed in a real data application to the Traffic, Asthma and Genetics (TAG) Study (N = 4465 observations). When appropriate external weights are unavailable, we recommend to use internal weights from the study population itself to construct weighted GRS for GxE interaction studies. If the SNPs were chosen because a strong marginal genetic effect was hypothesized, GRS-marginal-internal should be used. If the SNPs were chosen because of their collective impact on the biological mechanisms mediating the environmental effect (hypothesis of predominant interactions) GRS-interaction-training should be applied.

X-Ray Processing of ChaMPlane Fields: Methods and Initial Results for Selected Anti-Galactic Center Fields

NASA Astrophysics Data System (ADS)

Hong, JaeSub; van den Berg, Maureen; Schlegel, Eric M.; Grindlay, Jonathan E.; Koenig, Xavier; Laycock, Silas; Zhao, Ping

2005-12-01

We describe the X-ray analysis procedure of the ongoing Chandra Multiwavelength Plane (ChaMPlane) Survey and report the initial results from the analysis of 15 selected anti-Galactic center observations (90deg

Functional Properties of Glutinous Rice Flour by Dry-Heat Treatment.

PubMed

Qin, Yang; Liu, Chengzhen; Jiang, Suisui; Cao, Jinmiao; Xiong, Liu; Sun, Qingjie

2016-01-01

Glutinous rice flour (GRF) and glutinous rice starch (GRS) were modified by dry-heat treatment and their rheological, thermal properties and freeze-thaw stability were evaluated. Compared with the native GRF and GRS, the water-holding ability of modified GRF and GRS were enhanced. Both the onset and peak temperatures of the modified samples increased while the endothermic enthalpy change decreased significantly (p < 0.05). Meanwhile, dry heating remarkably increased the apparent viscosities of both GRF and GRS. Importantly, compared with GRS samples, the storage modulus (G') and loss modulus (G") values of modified GRF increased more greatly and the tanδ values decreased more remarkably, indicating that the dry-heat treatment showed more impact on the GRF and a higher viscoelasticity compared with GRS. Our results suggest the dry-heat treatment of GRF is a more effective method than that of GRS, which omits the complex and tedious process for purifying GRS, and thereby has more practical applications in the food industry.

Functional Properties of Glutinous Rice Flour by Dry-Heat Treatment

PubMed Central

Qin, Yang; Liu, Chengzhen; Jiang, Suisui; Cao, Jinmiao; Xiong, Liu; Sun, Qingjie

2016-01-01

Glutinous rice flour (GRF) and glutinous rice starch (GRS) were modified by dry-heat treatment and their rheological, thermal properties and freeze-thaw stability were evaluated. Compared with the native GRF and GRS, the water-holding ability of modified GRF and GRS were enhanced. Both the onset and peak temperatures of the modified samples increased while the endothermic enthalpy change decreased significantly (p < 0.05). Meanwhile, dry heating remarkably increased the apparent viscosities of both GRF and GRS. Importantly, compared with GRS samples, the storage modulus (G') and loss modulus (G") values of modified GRF increased more greatly and the tanδ values decreased more remarkably, indicating that the dry-heat treatment showed more impact on the GRF and a higher viscoelasticity compared with GRS. Our results suggest the dry-heat treatment of GRF is a more effective method than that of GRS, which omits the complex and tedious process for purifying GRS, and thereby has more practical applications in the food industry. PMID:27537844

Preventing Jupiter's Great Red Spot from Turning Itself Inside-Out

NASA Astrophysics Data System (ADS)

Shetty, Sushil; Asay-Davis, Xylar; Marcus, Philip

2002-11-01

Previous simulations of Jupiter's Great Red Spot (GRS) have failed to reproduce its most prominent feature: its hollowness. Unlike most laboratory 2D vortices, where vorticity is peaked at the center, the GRS has nearly no fluid motion in its interior. The coherent fluid motion is confined to a narrow ring at the outer edge of the GRS that moves counter-clockwise around the vortex. Simulations show that isolated 2D vortices that are as hollow as the GRS are violently unstable, turning themselves inside-out within a few rotations of the vortex. How than can one explain the long-lived, stable GRS? The answer is that the GRS is not isolated but instead embedded in a system of east-west jet streams. The eastward jet streams correspond to strong (potential) vorticity gradients which act as guides for Rossby waves. We show that the interaction between the GRS and the Rossby waves stabilize the GRS. Furthermore, we show that the hollowness of the GRS is near its critical limit, so that if it were any more hollow it would become unstable. We suggest a plausible mechanism through which this critical hollowness is maintained.

An atlas of exotic variability in IGR J17091-3624: a comparison with GRS 1915+105

NASA Astrophysics Data System (ADS)

Court, J. M. C.; Altamirano, D.; Pereyra, M.; Boon, C. M.; Yamaoka, K.; Belloni, T.; Wijnands, R.; Pahari, M.

2017-07-01

We performed an analysis of all Rossi X-ray Timing Explorer observations of the low-mass X-ray binary (LMXB) and black hole candidate IGR J17091-3624 during the 2011-2013 outburst of the source. By creating light curves, hardness-intensity diagrams and power density spectra of each observation, we have created a set of nine variability 'classes' that phenomenologically describe the range of types of variability seen in this object. We compare our set of variability classes to those established by Belloni et al. to describe the similar behaviour of the LMXB GRS 1915+105, finding that some types of variability seen in IGR J17091-3624 are not represented in data of GRS 1915+105. We also use all available X-ray data of the 2011-2013 outburst of IGR J17091-3624 to analyse its long-term evolution, presenting the first detection of IGR J17091-3624 above 150 keV as well as noting the presence of 're-flares' during the later stages of the outburst. Using our results, we place new constraints on the mass and distance of the object, and find that it accretes at ≲33 per cent of its Eddington limit. As such, we conclude that Eddington-limited accretion can no longer be considered a sufficient or necessary criterion for GRS 1915+105-like variability to occur in LMXBs.

Validation of the Gifted Rating Scales–School Form in China

PubMed Central

Li, Huijun; Pfeiffer, Steven I.; Petscher, Yaacov; Kumtepe, Alper T.; Mo, Guofang

2015-01-01

The Gifted Rating Scales–School Form (GRS-S), a teacher-completed rating scale, is designed to identify five types of giftedness and motivation. This study examines the reliability and validity of a Chinese-translated version of the GRS-S with a sample of Chinese elementary and middle school students (N = 499). The Chinese GRSS was found to have high internal consistency. Results of the confirmatory factor analysis corroborated the six-factor solution of the original GRS-S. Comparison of the GRS-S scores and measures of academic performance provide preliminary support for the criterion validity of the Chinese-translated GRS-S. Significant age and gender differences on the Chinese GRS-S were found. Results provide preliminary support for the Chinese version of the GRS-S as a reliable and valid measure of giftedness for Chinese students. PMID:26346730

Chandra Deep X-ray Observation of a Typical Galactic Plane Region and Near-Infrared Identification

NASA Technical Reports Server (NTRS)

Ebisawa, K.; Tsujimoto, M.; Paizis, A.; Hamaguichi, K.; Bamba, A.; Cutri, R.; Kaneda, H.; Maeda, Y.; Sato, G.; Senda, A.

2004-01-01

Using the Chandra Advanced CCD Imaging Spectrometer Imaging array (ACIS-I), we have carried out a deep hard X-ray observation of the Galactic plane region at (l,b) approx. (28.5 deg,0.0 deg), where no discrete X-ray source has been reported previously. We have detected 274 new point X-ray sources (4 sigma confidence) as well as strong Galactic diffuse emission within two partidly overlapping ACIS-I fields (approx. 250 sq arcmin in total). The point source sensitivity was approx. 3 x 10(exp -15)ergs/s/sq cm in the hard X-ray band (2-10 keV and approx. 2 x 10(exp -16) ergs/s/sq cm in the soft band (0.5-2 keV). Sum of all the detected point source fluxes account for only approx. 10 % of the total X-ray fluxes in the field of view. In order to explain the total X-ray fluxes by a superposition of fainter point sources, an extremely rapid increase of the source population is required below our sensitivity limit, which is hardly reconciled with any source distribution in the Galactic plane. Therefore, we conclude that X-ray emission from the Galactic plane has truly diffuse origin. Only 26 point sources were detected both in the soft and hard bands, indicating that there are two distinct classes of the X-ray sources distinguished by the spectral hardness ratio. Surface number density of the hard sources is only slightly higher than observed at the high Galactic latitude regions, strongly suggesting that majority of the hard X-ray sources are active galaxies seen through the Galactic plane. Following the Chandra observation, we have performed a near-infrared (NIR) survey with SOFI at ESO/NTT to identify these new X-ray sources. Since the Galactic plane is opaque in NIR, we did not see the background extragalactic sources in NIR. In fact, only 22 % of the hard sources had NIR counterparts which are most likely to be Galactic origin. Composite X-ray energy spectrum of those hard X-ray sources having NIR counterparts exhibits a narrow approx. 6.7 keV iron emission line, which is a signature of Galactic quiescent cataclysmic variables (CVs).

Origin of Low-Energy Spurious Peaks in Spectroscopic Measurements With Silicon Detectors

DOE PAGES

Giacomini, Gabriele; Huber, Alan; Redus, Robert; ...

2017-11-13

We report that when an uncollimated radioactive X-ray source illuminates a silicon PIN sensor, some ionizing events are generated in the nonimplanted gap between the active area of the sensor and the guard rings (GRs). Carriers can be collected by floating electrodes, i.e., electron accumulation layers at the silicon/oxide interface, and floating GRs. The crosstalk signals generated by these events create spurious peaks, replicas of the main peaks at either lower amplitude or of opposite polarity. Lastly, we explain this phenomenon as crosstalk caused by charge collected on these floating electrodes, which can be analyzed by means of an extensionmore » of Ramo theorem.« less

The tropospheric abundances of NH3 and PH3 in Jupiter's Great Red Spot, from Voyager IRIS observations

NASA Technical Reports Server (NTRS)

Griffith, Caitlin A.; Bezard, Bruno; Owen, Tobias; Gautier, Daniel

1992-01-01

The tropospheric abundances of NH3 and PH3 in Jupiter's Great Red Spot (GRS) are presently determined on the basis of a group of Voyager IRIS spectra, and compared with those of the surrounding South Tropical Zone (STZ) obtained from another two groups of IRIS spectra, in order to characterize the GRS's chemistry and dynamics. Although the GRS is believed to be a region of strong vertical transport, NH3 depletion is surprisingly found to occur below the tropopause within the GRS. Since one of the STZ's selections has a temperature-pressure profile similar to that of the GRS below the 300 mbar level, condensation cannot explain the low NH3 abundance in the GRS.

ISM gas studies towards the TeV PWN HESS J1825-137 and northern region

NASA Astrophysics Data System (ADS)

Voisin, F.; Rowell, G.; Burton, M. G.; Walsh, A.; Fukui, Y.; Aharonian, F.

2016-05-01

HESS J1825-137 is a pulsar wind nebula (PWN) whose TeV emission extends across ˜1 . Its large asymmetric shape indicates that its progenitor supernova interacted with a molecular cloud located in the north of the PWN as detected by previous CO Galactic survey (e.g. Lemiere, Terrier & Djannati-Ataï). Here, we provide a detailed picture of the interstellar medium (ISM) towards the region north of HESS J1825-137, with the analysis of the dense molecular gas from our 7 and 12 mm Mopra survey and the more diffuse molecular gas from the Nanten CO(1-0) and GRS 13CO(1-0) surveys. Our focus is the possible association between HESS J1825-137 and the unidentified TeV source to the north, HESS J1826-130. We report several dense molecular regions whose kinematic distance matched the dispersion measured distance of the pulsar. Among them, the dense molecular gas located at (RA, Dec.) = (18h421h,-13.282°) shows enhanced turbulence and we suggest that the velocity structure in this region may be explained by a cloud-cloud collision scenario. Furthermore, the presence of a H α rim may be the first evidence of the progenitor supernova remnant (SNR) of the pulsar PSR J1826-1334 as the distance between the H α rim and the TeV source matched with the predicted SNR radius RSNR ˜ 120 pc. From our ISM study, we identify a few plausible origins of the HESS J1826-130 emission, including the progenitor SNR of PSR J1826-1334 and the PWN G018.5-0.4 powered by PSR J1826-1256. A deeper TeV study however, is required to fully identify the origin of this mysterious TeV source.

The Planck Catalogue of Galactic Cold Clumps : PGCC

NASA Astrophysics Data System (ADS)

Montier, L.

The Planck satellite has provided an unprecedented view of the submm sky, allowing us to search for the dust emission of Galactic cold sources. Combining Planck-HFI all-sky maps in the high frequency channels with the IRAS map at 100um, we built the Planck catalogue of Galactic Cold Clumps (PGCC, Planck 2015 results. XXVIII), counting 13188 sources distributed over the whole sky, and following mainly the Galactic structures at low and intermediate latitudes. This is the first all-sky catalogue of Galactic cold sources obtained with a single instrument at this resolution and sensitivity, which opens a new window on star-formation processes in our Galaxy.

The galactic contribution to IceCube's astrophysical neutrino flux

DOE Office of Scientific and Technical Information (OSTI.GOV)

Denton, Peter B.; Marfatia, Danny; Weiler, Thomas J., E-mail: peterbd1@gmail.com, E-mail: dmarf8@hawaii.edu, E-mail: tom.weiler@vanderbilt.edu

2017-08-01

High energy neutrinos have been detected by IceCube, but their origin remains a mystery. Determining the sources of this flux is a crucial first step towards multi-messenger studies. In this work we systematically compare two classes of sources with the data: galactic and extragalactic. We assume that the neutrino sources are distributed according to a class of Galactic models. We build a likelihood function on an event by event basis including energy, event topology, absorption, and direction information. We present the probability that each high energy event with deposited energy E {sub dep}>60 TeV in the HESE sample is Galactic,more » extragalactic, or background. For Galactic models considered the Galactic fraction of the astrophysical flux has a best fit value of 1.3% and is <9.5% at 90% CL. A zero Galactic flux is allowed at <1σ.« less

Strong influence of dietary intake and physical activity on body fatness in elderly Japanese men: age-associated loss of polygenic resistance against obesity.

PubMed

Tanisawa, Kumpei; Ito, Tomoko; Sun, Xiaomin; Ise, Ryuken; Oshima, Satomi; Cao, Zhen-Bo; Sakamoto, Shizuo; Tanaka, Masashi; Higuchi, Mitsuru

2014-09-01

Genome-wide association studies identified single nucleotide polymorphisms (SNPs) associated with body mass index (BMI) in middle-aged populations; however, it is unclear whether these SNPs are associated with body fatness in elderly people. We examined the association between genetic risk score (GRS) from BMI-associated SNPs and body fatness in elderly Japanese men. We also examined the contribution of GRS, dietary macronutrient intake, and physical activity to body fatness by different age groups. GRS was calculated from 10 BMI-associated SNPs in 84 middle-aged (30-64 years) and 97 elderly (65-79 years) Japanese men; subjects were divided into low, middle, and high GRS groups. Dietary macronutrient intake was assessed using a questionnaire, and physical activity was evaluated using both a questionnaire and an accelerometer. The middle-aged individuals with a high GRS had greater BMI; waist circumference; and total abdominal fat, visceral fat, and subcutaneous fat areas than the middle-aged individuals with low GRS, whereas the indicators were not different between the GRS groups in elderly individuals. Multiple linear regression analysis showed that GRS was the strongest predictor of BMI, total abdominal fat, and visceral fat in the middle-aged group, whereas fat, alcohol, and protein intakes or vigorous-intensity physical activity were more strongly associated with these indicators than was GRS in the elderly group. These results suggest that GRS from BMI-associated SNPs is not predictive of body fatness in elderly Japanese men. The stronger contribution of dietary macronutrient intake and physical activity to body fatness may attenuate the genetic predisposition in elderly men.

The endoscopy Global Rating Scale – Canada: Development and implementation of a quality improvement tool

PubMed Central

MacIntosh, Donald; Dubé, Catherine; Hollingworth, Roger; van Zanten, Sander Veldhuyzen; Daniels, Sandra; Ghattas, George

2013-01-01

BACKGROUND: Increasing use of gastrointestinal endoscopy, particularly for colorectal cancer screening, and increasing emphasis on health care quality highlight the need for endoscopy facilities to review the quality of the service they offer. OBJECTIVE: To adapt the United Kingdom Global Rating Scale (UK-GRS) to develop a web-based and patient-centred tool to assess and improve the quality of endoscopy services provided. METHODS: Based on feedback from 22 sites across Canada that completed the UK endoscopy GRS, and integrating results of the Canadian consensus on safety and quality indicators in endoscopy and other Canadian consensus reports, a working group of endoscopists experienced with the GRS developed the GRS-Canada (GRS-C). RESULTS: The GRS-C mirrors the two dimensions (clinical quality and quality of the patient experience) and 12 patient-centred items of the UK-GRS, but was modified to apply to Canadian health care infrastructure, language and current practice. Each item is assessed by a yes/no response to eight to 12 statements that are divided into levels graded D (basic) through A (advanced). A core team consisting of a booking clerk, charge nurse and the physician responsible for the unit is recommended to complete the GRS-C twice yearly. CONCLUSION: The GRS-C is intended to improve endoscopic services in Canada by providing endoscopy units with a straightforward process to review the quality of the service they provide. PMID:23472242

VizieR Online Data Catalog: Planck Catalogue of Galactic cold clumps (PGCC) (Planck+, 2016)

NASA Astrophysics Data System (ADS)

Planck Collaboration; Ade, P. A. R.; Aghanim, N.; Arnaud, M.; Ashdown, M.; Aumont, J.; Baccigalupi, C.; Banday, A. J.; Barreiro, R. B.; Bartolo, N.; Battaner, E.; Benabed, K.; Benoit, A.; Benoit-Levy, A.; Bernard, J.-P.; Bersanelli, M.; Bielewicz, P.; Bonaldi, A.; Bonavera, L.; Bond, J. R.; Borrill, J.; Bouchet, F. R.; Boulanger, F.; Bucher, M.; Burigana, C.; Butler, R. C.; Calabrese, E.; Catalano, A.; Chamballu, A.; Chiang, H. C.; Christensen, P. R.; Clements, D. L.; Colombi, S.; Colombo, L. P. L.; Combet, C.; Couchot, F.; Coulais, A.; Crill, B. P.; Curto, A.; Cuttaia, F.; Danese, L.; Davies, R. D.; Davis, R. J.; de Bernardis, P.; De Rosa, A.; de Zotti, G.; Delabrouille, J.; Desert, F.-X.; Dickinson, C.; Diego, J. M.; Dole, H.; Donzelli, S.; Dore, O.; Douspis, M.; Ducout, A.; Dupac, X.; Efstathiou, G.; Elsner, F.; Ensslin, T. A.; Eriksen, H. K.; Falgarone, E.; Fergusson, J.; Fergusson, J.; Finelli, F.; Forni, O.; Frailis, M.; Fraisse, A. A.; Franceschi, E.; Frejsel, A.; Galeotta, S.; Galli, S.; Ganga, K.; Giard, M.; Giraud-Heraud, Y.; Gjerlow, E.; Gonzalez-Nuevo, J.; Gorsk, I. K. M.; Gratton, S.; Gregorio, A.; Gruppuso, A.; Gudmundsson, J. E.; Hansen, F. K.; Hanson, D.; Harrison, D. L.; Helou, G.; Henrot-Versille, S.; Hernandez-Monteagudo, C.; Herranz, D.; Hildebrandt, S. R.; Hivon, E.; Hobson, M.; Holmes, W. A.; Hornstrup, A.; Hovest, W.; Huffenberger, K. M.; Hurier, G.; Jaffe, A. H.; Jaffe, T. R.; Jones, W. C.; Juvela, M.; Keihanen, E.; Keskitalo, R.; Kisner, T. S.; Knoche, J.; Kunz, M.; Kurki-Suonio, H.; Lagache, G.; Lamarre, J.-M.; Lasenby, A.; Lattanzi, M.; Lawrence, C. R.; Leonardi, R.; Lesgourgues, J.; Levrier, F.; Liguori, M.; Lilje, P. B.; Linden-Vornle, M.; Lopez-Caniego, M.; Lubin, P. M.; Macias-Perez, J. F.; Maggio, G.; Maino, D.; Mandolesi, N.; Mangilli, A.; Marshall, D. J.; Martin, P. G.; Martinez-Gonzalez, E.; Masi, S.; Matarrese, S.; Mazzotta, P.; McGehee, P.; Melchiorri, A.; Mendes, L.; Mennella, A.; Migliaccio, M.; Mitra, S.; Miville-Deschenes, M.-A.; Moneti, A.; Montier, L.; Morgante, G.; Mortlock, D.; Moss, A.; Munshi, D.; Murphy, J. A.; Naselsky, P.; Nati, F.; Natoli, P.; Netterfield, C. B.; Norgaard-Nielsen, H. U.; Noviello, F.; Novikov, D.; Novikov, I.; Oxborrow, C. A.; Paci, F.; Pagano, L.; Pajot, F.; Paladini, R.; Paoletti, D.; Pasian, F.; Patanchon, G.; Pearson, T. J.; Pelkonen, V.-M.; Perdereau, O.; Perotto, L.; Perrotta, F.; Pettorino, V.; Piacentini, F.; Piat, M.; Pierpaoli, E.; Pietrobon, D.; Plaszczynski, S.; Pointecouteau, E.; Polenta, G.; Pratt, G. W.; Prezeau, G.; Prunet, S.; Puget, J.-L.; Rachen, J. P.; Reach, W. T.; Rebolo, R.; Reinecke, M.; Remazeilles, M.; Renault, C.; Renzi, A.; Ristorcelli, I.; Rocha, G.; Rosset, C.; Rossetti, M.; Roudier, G.; Rubino-Martin, J. A.; Rusholme, B.; Sandri, M.; Santos, D.; Savelainen, M.; Savini, G.; Scott, D.; Seiffert, M. D.; Shellard, E. P. S.; Spencer, L. D.; Stolyarov, V.; Sudiwala, R.; Sunyaev, R.; Sutton, D.; Suur-Uski, A.-S.; Sygnet, J.-F.; Tauber, J. A.; Terenzi, L.; Toffolatti, L.; Tomasi, M.; Tristram, M.; Tucci, M.; Tuovinen, J.; Umana, G.; Valenziano, L.; Valiviita, J.; van Tent, B.; Vielva, P.; Villa, F.; Wade, L. A.; Wandelt, B. D.; Wehus, I. K.; Yvon, D.; Zacchei, A.; Zonca, A.

2017-01-01

The Planck Catalogue of Galactic Cold Clumps (PGCC) is a list of 13188 Galactic sources and 54 sources located in the Small and Large Magellanic Clouds. The sources have been identified in Planck data as sources colder than their environment. It has been built using the 48 months Planck data at 857, 545, and 353GHz combined with the 3THz IRAS data. (1 data file).

The Energetic Gamma-Ray Experiment Telescope (EGRET) Science Symposium

NASA Technical Reports Server (NTRS)

Fichtel, Carl E. (Editor); Hunter, Stanley D. (Editor); Sreekumar, Parameswaran (Editor); Stecker, Floyd W. (Editor)

1990-01-01

The principle purpose of this symposium is to provide the EGRET (Energetic Gamma-Ray Experiment Telescope) scientists with an opportunity to study and improve their understanding of high energy gamma ray astronomy. The Symposium began with the galactic diffusion radiation both because of its importance in studying galactic cosmic rays, galactic structure, and dynamic balance, and because an understanding of its characteristics is important in the study of galactic sources. The galactic objects to be reviewed included pulsars, bursts, solar flares, and other galactic sources of several types. The symposium papers then proceeded outward from the Milky Way to normal galaxies, active galaxies, and the extragalactic diffuse radiation.

Health planners and local public finance--the case for revenue sharing.

PubMed Central

Rocheleau, B; Warren, S

1980-01-01

Little attention has been paid by health planners or researchers to questions of local public finance. However, a review of the literature concerning general revenue sharing (GRS) funds indicated that about $400 million per year from this source is spent on health services and resources. GRS funds, about $6.4 billion per year, are distributed to more than 39,000 State, county, and city governments. The 1976 amendments to the General Revenue Sharing Act eliminated restrictions on the use of the funds, and they can be employed as matching funds for other Federal monies. An exploratory study of the use of GRS funds for health purposes was conducted in several localities, with particular attention to the health systems agencies. Its results confirmed that there are wide variations among localities in the use of revenue-sharing funds to support health services. Also, not only did the health systems agencies' officials have little impact on the allocation of revenue sharing funds, but only in one locale had an HSA official taken a direct role in the budgetary process. Health planners, who were interviewed during the study, described what they considered their agencies' proper role in local budgetary matters. PMID:6775344

Health planners and local public finance--the case for revenue sharing.

PubMed

Rocheleau, B; Warren, S

1980-01-01

Little attention has been paid by health planners or researchers to questions of local public finance. However, a review of the literature concerning general revenue sharing (GRS) funds indicated that about $400 million per year from this source is spent on health services and resources. GRS funds, about $6.4 billion per year, are distributed to more than 39,000 State, county, and city governments. The 1976 amendments to the General Revenue Sharing Act eliminated restrictions on the use of the funds, and they can be employed as matching funds for other Federal monies. An exploratory study of the use of GRS funds for health purposes was conducted in several localities, with particular attention to the health systems agencies. Its results confirmed that there are wide variations among localities in the use of revenue-sharing funds to support health services. Also, not only did the health systems agencies' officials have little impact on the allocation of revenue sharing funds, but only in one locale had an HSA official taken a direct role in the budgetary process. Health planners, who were interviewed during the study, described what they considered their agencies' proper role in local budgetary matters.

Velocity and vorticity measurements of Jupiter's Great Red Spot using automated cloud feature tracking

NASA Astrophysics Data System (ADS)

Choi, David S.; Banfield, Don; Gierasch, Peter; Showman, Adam P.

2007-05-01

We have produced mosaics of the Great Red Spot (GRS) using images taken by the Galileo spacecraft in May 2000, and have measured the winds of the GRS using an automated algorithm that does not require manual cloud tracking. Our technique yields a high-density, regular grid of wind velocity vectors that is advantageous over a limited number of scattered wind vectors that result from manual cloud tracking. The high-velocity collar of the GRS is clearly seen from our velocity vector map, and highest wind velocities are measured to be around 170 m s -1. The high resolution of the mosaics has also enabled us to map turbulent eddies inside the chaotic central region of the GRS, similar to those mapped by Sada et al. [Sada, P.V., Beebe, R.F., Conrath, B.J., 1996. Icarus 119, 311-335]. Using the wind velocity measurements, we computed particle trajectories around the GRS as well as maps of relative and absolute vorticities. We have discovered a narrow ring of cyclonic vorticity that surrounds the main anti-cyclonic high-velocity collar. This narrow ring appears to correspond to a ring surrounding the GRS that is bright in 5 μm [Terrile, R.J., Beebe, R.F., 1979. Science 204, 948-951]. It appears that this cyclonic ring is not a transient feature of the GRS, as we have discovered it in a re-analysis of Galileo data taken in 1996 first analyzed by Vasavada et al. [Vasavada, A.R., and 13 colleagues, 1998. Icarus 135, 265-275]. We also calculate how absolute vorticity changes as a function of latitude along a trajectory around the GRS and compare these measurements to similar ones performed by Dowling and Ingersoll [Dowling, T.E., Ingersoll, A.P., 1988. J. Atmos. Sci. 45, 1380-1396] using Voyager data. We show no dramatic evolution in the structure of the GRS since the Voyager era except for additional evidence for a counter-rotating GRS core, an increase in velocity in the main velocity collar, and an overall decrease in the length of the GRS.

Resolved, expanding jets in the Galactic black hole candidate XTE J1908+094

NASA Astrophysics Data System (ADS)

Rushton, A. P.; Miller-Jones, J. C. A.; Curran, P. A.; Sivakoff, G. R.; Rupen, M. P.; Paragi, Z.; Spencer, R. E.; Yang, J.; Altamirano, D.; Belloni, T.; Fender, R. P.; Krimm, H. A.; Maitra, D.; Migliari, S.; Russell, D. M.; Russell, T. D.; Soria, R.; Tudose, V.

2017-07-01

Black hole X-ray binaries undergo occasional outbursts caused by changing inner accretion flows. Here we report high angular resolution radio observations of the 2013 outburst of the black hole candidate X-ray binary system XTE J1908+094, using data from the Very Long Baseline Array and European VLBI Network. We show that following a hard-to-soft state transition, we detect moving jet knots that appear asymmetric in morphology and brightness, and expand to become laterally resolved as they move away from the core, along an axis aligned approximately -11° east of north. We initially see only the southern component, whose evolution gives rise to a 15-mJy radio flare and generates the observed radio polarization. This fades and becomes resolved out after 4 days, after which a second component appears to the north, moving in the opposite direction. From the timing of the appearance of the knots relative to the X-ray state transition, a 90° swing of the inferred magnetic field orientation, the asymmetric appearance of the knots, their complex and evolving morphology, and their low speeds, we interpret the knots as working surfaces where the jets impact the surrounding medium. This would imply a substantially denser environment surrounding XTE J1908+094 than has been inferred to exist around the microquasar sources GRS 1915+105 and GRO J1655-40.

36 CFR 1227.14 - How do I obtain copies of the GRS?

Code of Federal Regulations, 2010 CFR

2010-07-01

... ADMINISTRATION RECORDS MANAGEMENT GENERAL RECORDS SCHEDULES § 1227.14 How do I obtain copies of the GRS? (a) The GRS and instructions for their use are available online at http://www.archives.gov/records-mgmt/ardor...

Thermal structure and dynamics of the Jovian Atmosphere. 1: The Great Red Spot

NASA Technical Reports Server (NTRS)

Flasar, F. M.; Cunrath, B. J.; Pirraglia, J. A.; Clark, P. C.; French, R. G.; Gierasch, P. J.

1980-01-01

Temperatures and thermal winds, derived from Voyager infrared spectroscopy (IRIS) data over the Great Red Spot (GRS) and its environs, are presented. The atmosphere over the GRS is characterized by a tropopause which is cold relative to its environment and an upper stratosphere which is relatively warm. The cold tropopause implies a decrease in anticyclonic vorticity with height above 500 mb through the lower stratosphere. IRIS observations at 5 microns indicate little emission from the GRS itself, but enhanced emission in a ring about it, in agreement with recent ground based results. The behavior of the tropopause and 5 micron temperatures can be consistently interpreted as resulting from a circulation which rises within the GRS and subsides in the area around it. The explanation of the upper stratospheric temperatures is not so straightforward. A previous suggestion that they may be a manifestation of the linear vertical propagation of Rossby waves appears inconsistent with the gross east-west symmetry in the stratospheric temperatures over the GRS. The implications of the present results for various theoretical models of the GRS are examined, and the possibility that latent heat release drives the GRS is discussed.

Detection of extended galactic sources with an underwater neutrino telescope

DOE Office of Scientific and Technical Information (OSTI.GOV)

Leisos, A.; Tsirigotis, A. G.; Tzamarias, S. E.

2014-11-18

In this study we investigate the discovery capability of a Very Large Volume Neutrino Telescope to Galactic extended sources. We focus on the brightest HESS gamma rays sources which are considered also as very high energy neutrino emitters. We use the unbinned method taking into account both the spatial and the energy distribution of high energy neutrinos and we investigate parts of the Galactic plane where nearby potential neutrino emitters form neutrino source clusters. Neutrino source clusters as well as isolated neutrino sources are combined to estimate the observation period for 5 sigma discovery of neutrino signals from these objects.

KM3NeT/ARCA sensitivity to point-like neutrino sources

NASA Astrophysics Data System (ADS)

Trovato, A.; KM3NeT Collaboration

2017-09-01

KM3NeT is network of deep-sea neutrino telescopes in the Mediterranean Sea aiming at the discovery of cosmic neutrino sources (ARCA) and the determination of the neutrino mass hierarchy (ORCA). The geographical location of KM3NeT in the Northern hemisphere allows to observe most of the Galactic Plane, including the Galactic Centre. Thanks to its good angular resolution, prime targets of KM3NeT/ARCA are point-like neutrino sources and in particular galactic sources.

The Stellar-mass Black Hole IGR J17091-3624 is in an Active State

NASA Astrophysics Data System (ADS)

Miller, J. M.; Reynolds, M. T.; Cenko, B.; Kennea, J.

2018-02-01

IGR J17091-3624 is a recurrent transient source, and a strong black hole candidate. The source has shown many of the same X-ray timing behaviors and "states" as GRS 1915+105 (e.g., Altamirano et al. 2011, Court et al. 2017), as well as relativistic disk reflection and strong winds (Reis et al. 2012, Xu et al. 2017; King et al. 2012).

Transformation of Chlorinated Hydrocarbons on Synthetic Green Rusts

EPA Science Inventory

Green rusts (GRs) are layered double hydroxides that contain both ferrous and ferric ions in their structure. GRs can potentially serve as a chemical reductant for degradation of chlorinated hydrocarbons. GRs are found in zerovalent iron based permeable reactive barriers and in c...

A genetic risk score is associated with polycystic ovary syndrome-related traits.

PubMed

Lee, Hyejin; Oh, Jee-Young; Sung, Yeon-Ah; Chung, Hye Won

2016-01-01

Is a genetic risk score (GRS) associated with polycystic ovary syndrome (PCOS) and its related clinical features? The GRS calculated by genome-wide association studies (GWASs) was significantly associated with PCOS status and its related clinical features. PCOS is a heterogeneous disorder and is characterized by oligomenorrhea, hyperandrogenism and polycystic ovary morphology. Although recent GWASs have identified multiple genes associated with PCOS, a comprehensive genetic risk study of these loci with PCOS and related traits (e.g. free testosterone, menstruation number/year and ovarian morphology) has not been performed. This study was designed as a cross-sectional case-control study. We recruited 862 women with PCOS and 860 controls. Women with PCOS were divided into four subgroups: (1) oligomenorrhea + hyperandrogenism + polycystic ovary, (2) oligomenorrhea + hyperandrogenism, (3) oligomenorrhea + polycystic ovary and (4) hyperandrogenism + polycystic ovary. Genomic DNA was genotyped for the PCOS susceptibility loci using the HumanOmni1-Quad v1 array. Venous blood was drawn in the early follicular phase to measure baseline metabolic and hormonal parameters. A GRS was calculated by summing the number of risk alleles from 11 single-nucleotide polymorphisms (SNPs) that were identified in previous GWASs on PCOS. A weighted GRS (wGRS) was calculated by multiplying the number of risk alleles for each SNP by its estimated effect (beta) obtained from the association analysis. The GRS was higher in women with PCOS than in controls (8.8 versus 8.2, P < 0.01) and was significantly associated with PCOS after adjusting for age and BMI. An analysis of GRS quartiles (Q1 = 3-5, Q2 = 6-8, Q3 = 9-11, Q4 = 12-15) revealed that the subjects in the highest quartile showed a remarkable increased risk of PCOS compared with those in the lowest quartile (odds ratio = 6.28, P < 0.001). Free testosterone level, menstruation number per year, ovarian volume and ovarian follicle numbers were significantly associated with the GRS (in all cases, P < 0.01). The wGRS yielded similar results. We used 11 loci for the calculation of GRS, but a higher number of PCOS risk alleles was reported in previous studies. Therefore, further studies should assess the value of GRS including the additional SNPs related to PCOS. Although a GRS of ≥12 was significantly associated with PCOS, the GRS showed a poor predictive value; therefore, the use of genetic information based on current GWAS data only may present problems. The GRS could be used to identify asymptomatic individuals among people at risk and stratify them into accurate risk categories for the purpose of individualizing treatment approaches, which could potentially improve health outcomes. None of the authors have any conflicts of interest to declare. No funding was obtained for the study. © The Author 2015. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Planck 2015 results. XXVIII. The Planck Catalogue of Galactic cold clumps

NASA Astrophysics Data System (ADS)

Planck Collaboration; Ade, P. A. R.; Aghanim, N.; Arnaud, M.; Ashdown, M.; Aumont, J.; Baccigalupi, C.; Banday, A. J.; Barreiro, R. B.; Bartolo, N.; Battaner, E.; Benabed, K.; Benoît, A.; Benoit-Lévy, A.; Bernard, J.-P.; Bersanelli, M.; Bielewicz, P.; Bonaldi, A.; Bonavera, L.; Bond, J. R.; Borrill, J.; Bouchet, F. R.; Boulanger, F.; Bucher, M.; Burigana, C.; Butler, R. C.; Calabrese, E.; Catalano, A.; Chamballu, A.; Chiang, H. C.; Christensen, P. R.; Clements, D. L.; Colombi, S.; Colombo, L. P. L.; Combet, C.; Couchot, F.; Coulais, A.; Crill, B. P.; Curto, A.; Cuttaia, F.; Danese, L.; Davies, R. D.; Davis, R. J.; de Bernardis, P.; de Rosa, A.; de Zotti, G.; Delabrouille, J.; Désert, F.-X.; Dickinson, C.; Diego, J. M.; Dole, H.; Donzelli, S.; Doré, O.; Douspis, M.; Ducout, A.; Dupac, X.; Efstathiou, G.; Elsner, F.; Enßlin, T. A.; Eriksen, H. K.; Falgarone, E.; Fergusson, J.; Finelli, F.; Forni, O.; Frailis, M.; Fraisse, A. A.; Franceschi, E.; Frejsel, A.; Galeotta, S.; Galli, S.; Ganga, K.; Giard, M.; Giraud-Héraud, Y.; Gjerløw, E.; González-Nuevo, J.; Górski, K. M.; Gratton, S.; Gregorio, A.; Gruppuso, A.; Gudmundsson, J. E.; Hansen, F. K.; Hanson, D.; Harrison, D. L.; Helou, G.; Henrot-Versillé, S.; Hernández-Monteagudo, C.; Herranz, D.; Hildebrandt, S. R.; Hivon, E.; Hobson, M.; Holmes, W. A.; Hornstrup, A.; Hovest, W.; Huffenberger, K. M.; Hurier, G.; Jaffe, A. H.; Jaffe, T. R.; Jones, W. C.; Juvela, M.; Keihänen, E.; Keskitalo, R.; Kisner, T. S.; Knoche, J.; Kunz, M.; Kurki-Suonio, H.; Lagache, G.; Lamarre, J.-M.; Lasenby, A.; Lattanzi, M.; Lawrence, C. R.; Leonardi, R.; Lesgourgues, J.; Levrier, F.; Liguori, M.; Lilje, P. B.; Linden-Vørnle, M.; López-Caniego, M.; Lubin, P. M.; Macías-Pérez, J. F.; Maggio, G.; Maino, D.; Mandolesi, N.; Mangilli, A.; Marshall, D. J.; Martin, P. G.; Martínez-González, E.; Masi, S.; Matarrese, S.; Mazzotta, P.; McGehee, P.; Melchiorri, A.; Mendes, L.; Mennella, A.; Migliaccio, M.; Mitra, S.; Miville-Deschênes, M.-A.; Moneti, A.; Montier, L.; Morgante, G.; Mortlock, D.; Moss, A.; Munshi, D.; Murphy, J. A.; Naselsky, P.; Nati, F.; Natoli, P.; Netterfield, C. B.; Nørgaard-Nielsen, H. U.; Noviello, F.; Novikov, D.; Novikov, I.; Oxborrow, C. A.; Paci, F.; Pagano, L.; Pajot, F.; Paladini, R.; Paoletti, D.; Pasian, F.; Patanchon, G.; Pearson, T. J.; Pelkonen, V.-M.; Perdereau, O.; Perotto, L.; Perrotta, F.; Pettorino, V.; Piacentini, F.; Piat, M.; Pierpaoli, E.; Pietrobon, D.; Plaszczynski, S.; Pointecouteau, E.; Polenta, G.; Pratt, G. W.; Prézeau, G.; Prunet, S.; Puget, J.-L.; Rachen, J. P.; Reach, W. T.; Rebolo, R.; Reinecke, M.; Remazeilles, M.; Renault, C.; Renzi, A.; Ristorcelli, I.; Rocha, G.; Rosset, C.; Rossetti, M.; Roudier, G.; Rubiño-Martín, J. A.; Rusholme, B.; Sandri, M.; Santos, D.; Savelainen, M.; Savini, G.; Scott, D.; Seiffert, M. D.; Shellard, E. P. S.; Spencer, L. D.; Stolyarov, V.; Sudiwala, R.; Sunyaev, R.; Sutton, D.; Suur-Uski, A.-S.; Sygnet, J.-F.; Tauber, J. A.; Terenzi, L.; Toffolatti, L.; Tomasi, M.; Tristram, M.; Tucci, M.; Tuovinen, J.; Umana, G.; Valenziano, L.; Valiviita, J.; Van Tent, B.; Vielva, P.; Villa, F.; Wade, L. A.; Wandelt, B. D.; Wehus, I. K.; Yvon, D.; Zacchei, A.; Zonca, A.

2016-09-01

We present the Planck Catalogue of Galactic Cold Clumps (PGCC), an all-sky catalogue of Galactic cold clump candidates detected by Planck. This catalogue is the full version of the Early Cold Core (ECC) catalogue, which was made available in 2011 with the Early Release Compact Source Catalogue (ERCSC) and which contained 915 high signal-to-noise sources. It is based on the Planck 48-month mission data that are currently being released to the astronomical community. The PGCC catalogue is an observational catalogue consisting exclusively of Galactic cold sources. The three highest Planck bands (857, 454, and 353 GHz) have been combined with IRAS data at 3 THz to perform a multi-frequency detection of sources colder than their local environment. After rejection of possible extragalactic contaminants, the PGCC catalogue contains 13188 Galactic sources spread across the whole sky, I.e., from the Galactic plane to high latitudes, following the spatial distribution of the main molecular cloud complexes. The median temperature of PGCC sources lies between 13 and 14.5 K, depending on the quality of the flux density measurements, with a temperature ranging from 5.8 to 20 K after removing the sources with the top 1% highest temperature estimates. Using seven independent methods, reliable distance estimates have been obtained for 5574 sources, which allows us to derive their physical properties such as their mass, physical size, mean density, and luminosity.The PGCC sources are located mainly in the solar neighbourhood, but also up to a distance of 10.5 kpc in the direction of the Galactic centre, and range from low-mass cores to large molecular clouds. Because of this diversity and because the PGCC catalogue contains sources in very different environments, the catalogue is useful for investigating the evolution from molecular clouds to cores. Finally, it also includes 54 additional sources located in the Small and Large Magellanic Clouds.

Planck 2015 results: XXVIII. The Planck Catalogue of Galactic cold clumps

DOE PAGES

Ade, P. A. R.; Aghanim, N.; Arnaud, M.; ...

2016-09-20

Here, we present the Planck Catalogue of Galactic Cold Clumps (PGCC), an all-sky catalogue of Galactic cold clump candidates detected by Planck. This catalogue is the full version of the Early Cold Core (ECC) catalogue, which was made available in 2011 with the Early Release Compact Source Catalogue (ERCSC) and which contained 915 high signal-to-noise sources. It is based on the Planck 48-month mission data that are currently being released to the astronomical community. The PGCC catalogue is an observational catalogue consisting exclusively of Galactic cold sources. The three highest Planck bands (857, 454, and 353 GHz) have been combinedmore » with IRAS data at 3 THz to perform a multi-frequency detection of sources colder than their local environment. After rejection of possible extragalactic contaminants, the PGCC catalogue contains 13188 Galactic sources spread across the whole sky, i.e., from the Galactic plane to high latitudes, following the spatial distribution of the main molecular cloud complexes. The median temperature of PGCC sources lies between 13 and 14.5 K, depending on the quality of the flux density measurements, with a temperature ranging from 5.8 to 20 K after removing the sources with the top 1% highest temperature estimates. Using seven independent methods, reliable distance estimates have been obtained for 5574 sources, which allows us to derive their physical properties such as their mass, physical size, mean density, and luminosity.The PGCC sources are located mainly in the solar neighbourhood, but also up to a distance of 10.5 kpc in the direction of the Galactic centre, and range from low-mass cores to large molecular clouds. Because of this diversity and because the PGCC catalogue contains sources in very different environments, the catalogue is useful for investigating the evolution from molecular clouds to cores. Finally, it also includes 54 additional sources located in the Small and Large Magellanic Clouds.« less

The Planck Catalogue of Galactic Cold Clumps : Looking at the early stages of star-formation

NASA Astrophysics Data System (ADS)

Montier, Ludovic

2015-08-01

The Planck satellite has provided an unprecedented view of the submm sky, allowing us to search for the dust emission of Galactic cold sources. Combining Planck-HFI all-sky maps in the high frequency channels with the IRAS map at 100um, we built the Planck catalogue of Galactic Cold Clumps (PGCC, Planck 2015 results XXVIII 2015), counting 13188 sources distributed over the whole sky, and following mainly the Galactic structures at low and intermediate latitudes. This is the first all-sky catalogue of Galactic cold sources obtained with a single instrument at this resolution and sensitivity, which opens a new window on star-formation processes in our Galaxy.I will briefly describe the colour detection method used to extract the Galactic cold sources, i.e., the Cold Core Colour Detection Tool (CoCoCoDeT, Montier et al. 2010), and its application to the Planck data. I will discuss the statistical distribution of the properties of the PGCC sources (in terms of dust temperature, distance, mass, density and luminosity), which illustrates that the PGCC catalogue spans a large variety of environments and objects, from molecular clouds to cold cores, and covers various stages of evolution. The Planck catalogue is a very powerful tool to study the formation and the evolution of prestellar objects and star-forming regions.I will finally present an overview of the Herschel Key Program Galactic Cold Cores (PI. M.Juvela), which allowed us to follow-up about 350 Planck Galactic Cold Clumps, in various stages of evolution and environments. With this program, the nature and the composition of the 5' Planck sources have been revealed at a sub-arcmin resolution, showing very different configurations, such as starless cold cores or multiple Young Stellar objects still embedded in their cold envelope.

A 1420 MHz Catalog of Compact Sources in the Northern Galactic Plane

DOE Office of Scientific and Technical Information (OSTI.GOV)

Taylor, A. R.; Leahy, D. A.; Sunstrum, C.

We present a catalog of compact sources of radio emission at 1420 MHz in the northern Galactic plane from the Canadian Galactic Plane Survey. The catalog contains 72,758 compact sources with an angular size less than 3′ within the Galactic longitude range 52° <  ℓ  < 192° down to a 5 σ detection level of ∼1.2 mJy. Linear polarization properties are included for 12,368 sources with signals greater than 4 σ{sub QU} in the Canadian Galactic Plane Survey (CGPS) Stokes Q and U images at the position of the total intensity peak. We compare CGPS flux densities with cataloged flux densities in themore » Northern VLA Sky Survey catalog for 10,897 isolated unresolved sources with CGPS flux density greater than 4 mJy to search for sources that show variable flux density on timescales of several years. We identify 146 candidate variables that exhibit high fractional variations between the two surveys. In addition, we identify 13 candidate transient sources that have CGPS flux density above 10 mJy but are not detected in the Northern VLA Sky Survey.« less

Rapid Monte Carlo Simulation of Gravitational Wave Galaxies

NASA Astrophysics Data System (ADS)

Breivik, Katelyn; Larson, Shane L.

2015-01-01

With the detection of gravitational waves on the horizon, astrophysical catalogs produced by gravitational wave observatories can be used to characterize the populations of sources and validate different galactic population models. Efforts to simulate gravitational wave catalogs and source populations generally focus on population synthesis models that require extensive time and computational power to produce a single simulated galaxy. Monte Carlo simulations of gravitational wave source populations can also be used to generate observation catalogs from the gravitational wave source population. Monte Carlo simulations have the advantes of flexibility and speed, enabling rapid galactic realizations as a function of galactic binary parameters with less time and compuational resources required. We present a Monte Carlo method for rapid galactic simulations of gravitational wave binary populations.

Monitoring of in-service geosynthetic reinforced soil (GRS) bridge abutments in Louisiana : research project capsule.

DOT National Transportation Integrated Search

2014-09-01

The primary objectives of this research are to monitor the : short-term and long-term behavior and performance of inservice : GRS-IBS abutments in the state of Louisiana, and to : verify important design factors and parameters for GRS-IBS : abutment,...

Radio Observations of Ultra-Luminous X-Ray Sources and their Implication for Models

NASA Astrophysics Data System (ADS)

Koerding, E. G.; Colbert, E. J. M.; Falcke, H.

2004-05-01

We present the results of a radio monitoring campaign to search for radio emission from nearby ultra-luminous X-ray sources (ULXs). These intriguing sources are bright off-nuclear X-ray point sources with luminosities exceeding LX > 1039 erg/sec. Assuming isotropic emission the Eddington Limit suggests that they harbor intermediate mass black holes. Due to the problems of this explanation also other possibilities are currently discussed, among them are anisotropic emission, super-Eddington accretion flows or relativistically beamed emission from microquasars. Detections of compact radio cores at the positions of ULXs would be a direct hint to jet-emission. However, as the ULX phenomenom is connected to star formation we have to assume that they are strongly accreting objects. Thus, similar to their nearest Galactic cousins, the very high state X-ray binaries (see e.g., GRS 1915), ULXs may show radio flares. A well-defined sample of the 9 nearest ULXs has been monitored eight times during 5 months with the Very Large Array in A and B configuration. Our limiting sensitivity is 0.15 mJy (4 σ ) for flares and 68 μ Jy for continuous emission. In M82 some ULXs seem to be connected to radio supernova remnants. Besides that no flare or continuous emission has been detected. As the timescales of radio flares in ULXs are highly uncertain, it could well be that we have undersampled the lightcurve. However, upper bounds for the probability to detect a flare can be given. The upper limits for the continuous emission are compared with the emission found in NGC 5408 X-1 and with quasars and microquasars. We show that these limits are well in agreement with the microblazar model using the Radio/X-ray correlation of XRBs and AGN. Thus, it could well be that ULXs are microblazers which may be radio loud.

Search for Extended Sources in the Galactic Plane Using Six Years of Fermi-Large Area Telescope Pass 8 Data above 10 GeV

DOE PAGES

Ackermann, M.; Ajello, M.; Baldini, L.; ...

2017-07-10

The spatial extension of a γ-ray source is an essential ingredient to determine its spectral properties, as well as its potential multiwavelength counterpart. The capability to spatially resolve γ-ray sources is greatly improved by the newly delivered Fermi-Large Area Telescope (LAT) Pass 8 event-level analysis, which provides a greater acceptance and an improved point-spread function, two crucial factors for the detection of extended sources. Here, we present a complete search for extended sources located within 7° from the Galactic plane, using 6 yr of Fermi-LAT data above 10 GeV. We find 46 extended sources and provide their morphological and spectralmore » characteristics. As a result, this constitutes the first catalog of hard Fermi-LAT extended sources, named the Fermi Galactic Extended Source Catalog, which allows a thorough study of the properties of the Galactic plane in the sub-TeV domain.« less

Search for Extended Sources in the Galactic Plane Using Six Years of Fermi -Large Area Telescope Pass 8 Data above 10 GeV

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ackermann, M.; Buehler, R.; Ajello, M.

The spatial extension of a γ -ray source is an essential ingredient to determine its spectral properties, as well as its potential multiwavelength counterpart. The capability to spatially resolve γ -ray sources is greatly improved by the newly delivered Fermi -Large Area Telescope (LAT) Pass 8 event-level analysis, which provides a greater acceptance and an improved point-spread function, two crucial factors for the detection of extended sources. Here, we present a complete search for extended sources located within 7° from the Galactic plane, using 6 yr of Fermi -LAT data above 10 GeV. We find 46 extended sources and providemore » their morphological and spectral characteristics. This constitutes the first catalog of hard Fermi -LAT extended sources, named the Fermi Galactic Extended Source Catalog, which allows a thorough study of the properties of the Galactic plane in the sub-TeV domain.« less

Search for Extended Sources in the Galactic Plane Using Six Years of Fermi-Large Area Telescope Pass 8 Data above 10 GeV

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ackermann, M.; Ajello, M.; Baldini, L.

The spatial extension of a γ-ray source is an essential ingredient to determine its spectral properties, as well as its potential multiwavelength counterpart. The capability to spatially resolve γ-ray sources is greatly improved by the newly delivered Fermi-Large Area Telescope (LAT) Pass 8 event-level analysis, which provides a greater acceptance and an improved point-spread function, two crucial factors for the detection of extended sources. Here, we present a complete search for extended sources located within 7° from the Galactic plane, using 6 yr of Fermi-LAT data above 10 GeV. We find 46 extended sources and provide their morphological and spectralmore » characteristics. As a result, this constitutes the first catalog of hard Fermi-LAT extended sources, named the Fermi Galactic Extended Source Catalog, which allows a thorough study of the properties of the Galactic plane in the sub-TeV domain.« less

Search for Extended Sources in the Galactic Plane Using Six Years of Fermi-Large Area Telescope Pass 8 Data above 10 GeV

NASA Astrophysics Data System (ADS)

Ackermann, M.; Ajello, M.; Baldini, L.; Ballet, J.; Barbiellini, G.; Bastieri, D.; Bellazzini, R.; Bissaldi, E.; Bloom, E. D.; Bonino, R.; Bottacini, E.; Brandt, T. J.; Bregeon, J.; Bruel, P.; Buehler, R.; Cameron, R. A.; Caragiulo, M.; Caraveo, P. A.; Castro, D.; Cavazzuti, E.; Cecchi, C.; Charles, E.; Chekhtman, A.; Cheung, C. C.; Chiaro, G.; Ciprini, S.; Cohen, J. M.; Costantin, D.; Costanza, F.; Cutini, S.; D'Ammando, F.; de Palma, F.; Desiante, R.; Digel, S. W.; Di Lalla, N.; Di Mauro, M.; Di Venere, L.; Favuzzi, C.; Fegan, S. J.; Ferrara, E. C.; Franckowiak, A.; Fukazawa, Y.; Funk, S.; Fusco, P.; Gargano, F.; Gasparrini, D.; Giglietto, N.; Giordano, F.; Giroletti, M.; Green, D.; Grenier, I. A.; Grondin, M.-H.; Guillemot, L.; Guiriec, S.; Harding, A. K.; Hays, E.; Hewitt, J. W.; Horan, D.; Hou, X.; Jóhannesson, G.; Kamae, T.; Kuss, M.; La Mura, G.; Larsson, S.; Lemoine-Goumard, M.; Li, J.; Longo, F.; Loparco, F.; Lubrano, P.; Magill, J. D.; Maldera, S.; Malyshev, D.; Manfreda, A.; Mazziotta, M. N.; Michelson, P. F.; Mitthumsiri, W.; Mizuno, T.; Monzani, M. E.; Morselli, A.; Moskalenko, I. V.; Negro, M.; Nuss, E.; Ohsugi, T.; Omodei, N.; Orienti, M.; Orlando, E.; Ormes, J. F.; Paliya, V. S.; Paneque, D.; Perkins, J. S.; Persic, M.; Pesce-Rollins, M.; Petrosian, V.; Piron, F.; Porter, T. A.; Principe, G.; Rainò, S.; Rando, R.; Razzano, M.; Razzaque, S.; Reimer, A.; Reimer, O.; Reposeur, T.; Sgrò, C.; Simone, D.; Siskind, E. J.; Spada, F.; Spandre, G.; Spinelli, P.; Suson, D. J.; Tak, D.; Thayer, J. B.; Thompson, D. J.; Torres, D. F.; Tosti, G.; Troja, E.; Vianello, G.; Wood, K. S.; Wood, M.

2017-07-01

The spatial extension of a γ-ray source is an essential ingredient to determine its spectral properties, as well as its potential multiwavelength counterpart. The capability to spatially resolve γ-ray sources is greatly improved by the newly delivered Fermi-Large Area Telescope (LAT) Pass 8 event-level analysis, which provides a greater acceptance and an improved point-spread function, two crucial factors for the detection of extended sources. Here, we present a complete search for extended sources located within 7° from the Galactic plane, using 6 yr of Fermi-LAT data above 10 GeV. We find 46 extended sources and provide their morphological and spectral characteristics. This constitutes the first catalog of hard Fermi-LAT extended sources, named the Fermi Galactic Extended Source Catalog, which allows a thorough study of the properties of the Galactic plane in the sub-TeV domain.

Accretion disk dynamics in X-ray binaries

NASA Astrophysics Data System (ADS)

Peris, Charith Srian

Accreting X-ray binaries consist of a normal star which orbits a compact object with the former transferring matter onto the later via an accretion disk. These accretion disks emit radiation across the entire electromagnetic spectrum. This thesis exploits two regions of the spectrum, exploring the (1) inner disk regions of an accreting black hole binary, GRS1915+105, using X-ray spectral analysis and (2) the outer accretion disks of a set of neutron star and black hole binaries using Doppler Tomography applied on optical observations. X-ray spectral analysis of black hole binary GRS1915+105: GRS1915+105 stands out as an exceptional black hole primarily due to the wild variability exhibited by about half of its X-ray observations. This study focused on the steady X-ray observations of the source, which were found to exhibit significant curvature in the harder coronal component within the RXTE/PCA band-pass. The roughly constant inner-disk radius seen in a majority of the steady-soft observations is strongly reminiscent of canonical soft state black-hole binaries. Remarkably, the steady-hard observations show the presence of growing truncation in the inner-disk. A majority of the steady observations of GRS1915+105 map to the states observed in canonical black hole binaries which suggests that within the complexity of this source is a simpler underlying basis of states. Optical tomography of X-ray binary systems: Doppler tomography was applied to the strong line features present in the optical spectra of X-ray binaries in order to determine the geometric structure of the systems' emitting regions. The point where the accretion stream hits the disk, also referred to as the "hotspot'', is clearly identified in the neutron star system V691 CrA and the black hole system Nova Muscae 1991. Evidence for stream-disk overflows exist in both systems, consistent with relatively high accretion rates. In contrast, V926 Sco does not show evidence for the presence of a hotspot which is consistent with its lower accretion state. The donor stars in V691 CrA and Nova Muscae 1991 were also detected.

IRAS and the Boston University Arecibo Galactic H I Survey: A catalog of cloud properties

NASA Technical Reports Server (NTRS)

Bania, Thomas M.

1992-01-01

The Infrared Astronomy Satellite (IRAS) Galactic Plane Surface Brightness Images were used to identify infrared emission associated with cool, diffuse H I clouds detected by the Boston University-Arecibo Galactic H I Survey. These clouds are associated with galactic star clusters, H II regions, and molecular clouds. Using emission-absorption experiments toward galactic H II regions, we determined the H I properties of cool H I clouds seen in absorption against the thermal continuum, including their kinematic distances. Correlations were then made between IRAS sources and these H II regions, thus some of the spatial confusion associated with the IRAS fields near the galactic plane was resolved since the distances to these sources was known. Because we can also correlate the BU-Arecibo clouds with existing CO surveys, these results will allow us to determine the intrinsic properties of the gas (neutral and ionized atomic as well as molecular) and dust for interstellar clouds in the inner galaxy. For the IRAS-identified H II region sample, we have established the far infrared (FIR) luminosities and galactic distribution of these sources.

Characterization of the Great Red Spot from Observations by Juno and the Earth-Based Supporting Campaign

NASA Astrophysics Data System (ADS)

Orton, Glenn S.; Hansen, Candice; Janssen, Michael A.; Bolton, Scott; Brown, Shannon; Eichstaedt, Gerald; Rogers, John; Ingersoll, Andrew P.; Li, Cheng; Momary, Thomas W.; Tabataba-Vakili, Fachreddin; Fletcher, Leigh; Fujiyoshi, Takuya; Greathouse, Thomas K.; Kasaba, Yasumasa; Simon, Amy A.; Sinclair, James Andrew; Stephens, Andrew W.; Wong, Michael H.; Donnelley, Padraig; Sanchez-Lavega, Agustin M.; Hueso, Ricardo; Juno-Support Observing Team

2017-10-01

On July 11, 2017, the Juno spacecraft made a close approach to Jupiter, passing over the center of Jupiter’s Great Red Spot (GRS). We summarize some of the results from Juno and supporting Earth-based measurements over a broad spectral range. Near-infrared images show that the GRS has higher-altitude particles than anywhere else outside polar regions, and that the darkest red center has the highest-altitude particles within the GRS. This region has darker swirl-like features and little detectable rotational motion. The red region forming the bulk of the GRS has both dark and light swirls and counter-clockwise winds that peak toward its periphery. JunoCam images, resolving down to ~6-7 km per pixel, shows very small, pink features that look like thunderstorm clouds in clusters on top of the brighter swirls. They are similar in morphology to whitish features that can be seen in zones north and south of the GRS. Close to the terminator, shadows some 7-12 km in length associated with these features can be resolved. A train of mesoscale gravity waves with ~70 km spacing spans a length of over 1,000 km near the northern periphery of the GRS between 15.8° and 15.9°S (planetocentric). Thermal-emission images in 5-µm and 8.7-µm spectral windows show most of the GRS as cold with high clouds, surrounded by a visibly-dark warm periphery that is consistent with being relatively clear. Longer-wavelength thermal observations indicate that the GRS is one of the coldest regions on the planet in the upper troposphere with indirect chemical indicators of vertical motions (e.g. para-H2, PH3) consistent with prevailing upwelling motion. NH3 is not enhanced with respect to the regions outside the GRS, most likely because its colder temperatures cause it to condense deeper than it does outside the GRS. A region immediately south of the GRS is anomalously warmer than elsewhere at the same latitude. The Microwave Radiometer (MWR) data are consistent with shorter-wavelength thermal-emission observations sensitive to the NH3 condensation level; they are currently being examined for indications of deep structure and depth.

GSFC Contributions to the NATO X-ray Astronomy Institute, Erice, July 1979. [X-ray spectra of supernova remants, galactic X-ray sources, active galactic nuclei, and clusters of galaxies

NASA Technical Reports Server (NTRS)

Holt, S. S.; Mushotzky, R. F.

1979-01-01

An overview of X-ray astronomical spectroscopy in general is presented and results obtained by HEAO 1 and 2 as well as earlier spacecraft are examined. Particular emphasis is given to the spectra of supernova remnants; galactic binary X-ray sources, cataclysmic variables, bulges, pulsars, and stars; the active nuclei of Seyfert 1 galaxy, BL Lac, and quasars; the diffuse X-ray background; and galactic clusters.

Milky Way scattering properties and intrinsic sizes of active galactic nuclei cores probed by very long baseline interferometry surveys of compact extragalactic radio sources

NASA Astrophysics Data System (ADS)

Pushkarev, A. B.; Kovalev, Y. Y.

2015-10-01

We have measured the angular sizes of radio cores of active galactic nuclei (AGNs) and analysed their sky distributions and frequency dependences to study synchrotron opacity in AGN jets and the strength of angular broadening in the interstellar medium. We have used archival very long baseline interferometry (VLBI) data of more than 3000 compact extragalactic radio sources observed at frequencies, ν, from 2 to 43 GHz to measure the observed angular size of VLBI cores. We have found a significant increase in the angular sizes of the extragalactic sources seen through the Galactic plane (|b| ≲ 10°) at 2, 5 and 8 GHz, about one-third of which show significant scattering. These sources are mainly detected in directions to the Galactic bar, the Cygnus region and a region with galactic longitudes 220° ≲ l ≲ 260° (the Fitzgerald window). The strength of interstellar scattering of the AGNs is found to correlate with the Galactic Hα intensity, free-electron density and Galactic rotation measure. The dependence of scattering strengths on source redshift is insignificant, suggesting that the dominant scattering screens are located in our Galaxy. The observed angular size of Sgr A* is found to be the largest among thousands of AGNs observed over the sky; we discuss possible reasons for this strange result. Excluding extragalactic radio sources with significant scattering, we find that the angular size of opaque cores in AGNs scales typically as ν-1, confirming predictions of a conical synchrotron jet model with equipartition.

A selection of giant radio sources from NVSS

DOE PAGES

Proctor, D. D.

2016-06-01

Results of the application of pattern-recognition techniques to the problem of identifying giant radio sources (GRSs) from the data in the NVSS catalog are presented, and issues affecting the process are explored. Decision-tree pattern-recognition software was applied to training-set source pairs developed from known NVSS large-angular-size radio galaxies. The full training set consisted of 51,195 source pairs, 48 of which were known GRSs for which each lobe was primarily represented by a single catalog component. The source pairs had a maximum separation ofmore » $$20^{\\prime} $$ and a minimum component area of 1.87 square arcmin at the 1.4 mJy level. The importance of comparing the resulting probability distributions of the training and application sets for cases of unknown class ratio is demonstrated. The probability of correctly ranking a randomly selected (GRS, non-GRS) pair from the best of the tested classifiers was determined to be 97.8 ± 1.5%. The best classifiers were applied to the over 870,000 candidate pairs from the entire catalog. Images of higher-ranked sources were visually screened, and a table of over 1600 candidates, including morphological annotation, is presented. These systems include doubles and triples, wide-angle tail and narrow-angle tail, S- or Z-shaped systems, and core-jets and resolved cores. In conclusion, while some resolved-lobe systems are recovered with this technique, generally it is expected that such systems would require a different approach.« less

OBSERVATION OF TeV GAMMA RAYS FROM THE FERMI BRIGHT GALACTIC SOURCES WITH THE TIBET AIR SHOWER ARRAY

DOE Office of Scientific and Technical Information (OSTI.GOV)

Amenomori, M.; Bi, X. J.; Ding, L. K.

2010-01-20

Using the Tibet-III air shower array, we search for TeV {gamma}-rays from 27 potential Galactic sources in the early list of bright sources obtained by the Fermi Large Area Telescope at energies above 100 MeV. Among them, we observe seven sources instead of the expected 0.61 sources at a significance of 2{sigma} or more excess. The chance probability from Poisson statistics would be estimated to be 3.8 x 10{sup -6}. If the excess distribution observed by the Tibet-III array has a density gradient toward the Galactic plane, the expected number of sources may be enhanced in chance association. Then, themore » chance probability rises slightly, to 1.2 x 10{sup -5}, based on a simple Monte Carlo simulation. These low chance probabilities clearly show that the Fermi bright Galactic sources have statistically significant correlations with TeV {gamma}-ray excesses. We also find that all seven sources are associated with pulsars, and six of them are coincident with sources detected by the Milagro experiment at a significance of 3{sigma} or more at the representative energy of 35 TeV. The significance maps observed by the Tibet-III air shower array around the Fermi sources, which are coincident with the Milagro {>=}3{sigma} sources, are consistent with the Milagro observations. This is the first result of the northern sky survey of the Fermi bright Galactic sources in the TeV region.« less

Infrared Spectroscopy of Black Hole Candidates

NASA Technical Reports Server (NTRS)

Colgan, Sean W.; Cotera, A. S.; Maloney, P. R.; Hollenbach, D. J.; DeVincenzi, Donald L. (Technical Monitor)

2000-01-01

ISO LWS and SWS observations of the approx. solar mass black hole candidates 1E1740.7-2942 and GRS1758-258 are presented. For 1E1740.7-2942, it has been suggested that the luminosity is provided in whole or part by Bondi-Hoyle accretion from a surrounding black hole (Bally & Leventhal 1991, Nat, 353,234). Maloney et al. (1997, ApJ482, L41) have predicted that detectable far-infrared line emission from [0I] (63 microns), [CII] (158 microns), [SiII] (35 microns) and other lines will arise from black holes which are embedded in molecular clouds. No strong line emission associated with either 1E1740.7-2942 or GRS1758-258 was detected, implying either that 1) these sources are not embedded in dense molecular clouds, or 2) that their average X-ray luminosity over the past 100 years is significantly lower than its current value. The measured upper limits to the line fluxes are compared with the models of Maloney et al.to constrain the properties of the ISM in the vicinity of these X-ray sources.

36 CFR 1227.14 - How do I obtain copies of the GRS?

Code of Federal Regulations, 2014 CFR

2014-07-01

... Administration, Modern Records Programs (NWM), 8601 Adelphi Road, College Park, MD 20740-6001, phone number (301... GRS? 1227.14 Section 1227.14 Parks, Forests, and Public Property NATIONAL ARCHIVES AND RECORDS ADMINISTRATION RECORDS MANAGEMENT GENERAL RECORDS SCHEDULES § 1227.14 How do I obtain copies of the GRS? (a) The...

36 CFR 1227.14 - How do I obtain copies of the GRS?

Code of Federal Regulations, 2012 CFR

2012-07-01

... Administration, Modern Records Programs (NWM), 8601 Adelphi Road, College Park, MD 20740-6001, phone number (301... GRS? 1227.14 Section 1227.14 Parks, Forests, and Public Property NATIONAL ARCHIVES AND RECORDS ADMINISTRATION RECORDS MANAGEMENT GENERAL RECORDS SCHEDULES § 1227.14 How do I obtain copies of the GRS? (a) The...

36 CFR 1227.14 - How do I obtain copies of the GRS?

Code of Federal Regulations, 2011 CFR

2011-07-01

... Administration, Modern Records Programs (NWM), 8601 Adelphi Road, College Park, MD 20740-6001, phone number (301... GRS? 1227.14 Section 1227.14 Parks, Forests, and Public Property NATIONAL ARCHIVES AND RECORDS ADMINISTRATION RECORDS MANAGEMENT GENERAL RECORDS SCHEDULES § 1227.14 How do I obtain copies of the GRS? (a) The...

Fermi Large Area Telescope third source catalog

DOE PAGES

Acero, F.; Ackermann, M.; Ajello, M.; ...

2015-06-12

Here, we present the third Fermi Large Area Telescope (LAT) source catalog (3FGL) of sources in the 100 MeV–300 GeV range. Based on the first 4 yr of science data from the Fermi Gamma-ray Space Telescope mission, it is the deepest yet in this energy range. Relative to the Second Fermi LAT catalog, the 3FGL catalog incorporates twice as much data, as well as a number of analysis improvements, including improved calibrations at the event reconstruction level, an updated model for Galactic diffuse γ-ray emission, a refined procedure for source detection, and improved methods for associating LAT sources with potential counterparts at other wavelengths. The 3FGL catalog includes 3033 sources abovemore » $$4\\sigma $$ significance, with source location regions, spectral properties, and monthly light curves for each. Of these, 78 are flagged as potentially being due to imperfections in the model for Galactic diffuse emission. Twenty-five sources are modeled explicitly as spatially extended, and overall 238 sources are considered as identified based on angular extent or correlated variability (periodic or otherwise) observed at other wavelengths. For 1010 sources we have not found plausible counterparts at other wavelengths. More than 1100 of the identified or associated sources are active galaxies of the blazar class; several other classes of non-blazar active galaxies are also represented in the 3FGL. Pulsars represent the largest Galactic source class. As a result, from source counts of Galactic sources we estimate that the contribution of unresolved sources to the Galactic diffuse emission is ~3% at 1 GeV.« less

Gamma ray cosmology: The extra galactic gamma spectrum and methods to detect the underlying source

NASA Technical Reports Server (NTRS)

Cline, David B.

1990-01-01

The possible sources of extragalactic gamma rays and methods to distinguish the different sources are discussed. The sources considered are early universe decays and annihilation of Particles, active galactic nuclei (AGN) sources, and baryon-antibaryon annihilation in a baryon symmetric cosmology. The energy spectrum and possible angular fluctuations due to these sources are described.

Prototype Environmental Assessment of the impacts of siting and construction of an SPS ground receiving station

NASA Technical Reports Server (NTRS)

Hill, J.

1980-01-01

A prototype assessment of the environmental impacts of siting and constructing a Satellite Power System (SPS) Ground Receiving Station (GRS) is reported. The objectives of the study were: (1) to develop an assessment of the nonmicrowave related impacts of the reference system SPS GRS on the natural environment; (2) to assess the impacts of GRS construction and operations in the context of actual baseline data for a site in the California desert; and (3) to identify critical GRS characteristics or parameters that are most significant in terms of the natural environment.

Polygenic risk scores in familial Alzheimer disease

PubMed Central

Tosto, Giuseppe; Bird, Thomas D.; Tsuang, Debby; Bennett, David A.; Boeve, Bradley F.; Cruchaga, Carlos; Faber, Kelley; Foroud, Tatiana M.; Farlow, Martin; Goate, Alison M.; Bertlesen, Sarah; Graff-Radford, Neill R.; Medrano, Martin; Lantigua, Rafael; Manly, Jennifer; Ottman, Ruth; Rosenberg, Roger; Schaid, Daniel J.; Schupf, Nicole; Stern, Yaakov; Sweet, Robert A.

2017-01-01

Objective: To investigate the association between a genetic risk score (GRS) and familial late-onset Alzheimer disease (LOAD) and its predictive value in families multiply affected by the disease. Methods: Using data from the National Institute on Aging Genetics Initiative for Late-Onset Alzheimer Disease (National Institute on Aging–Late-Onset Alzheimer's Disease Family Study), mixed regression models tested the association of familial LOAD with a GRS based on single nucleotide polymorphisms (SNPs) previously associated with LOAD. We modeled associations using unweighted and weighted scores with estimates derived from the literature. In secondary models, we adjusted subsequent models for presence of the APOE ε4 allele and further tested the interaction between APOE ε4 and the GRS. We constructed a similar GRS in a cohort of Caribbean Hispanic families multiply affected by LOAD by selecting the SNP with the strongest p value within the same regions. Results: In the NIA-LOAD families, the GRS was significantly associated with LOAD (odds ratio [OR] 1.29; 95% confidence interval 1.21–1.37). The results did not change after adjusting for APOE ε4. In Caribbean Hispanic families, the GRS also significantly predicted LOAD (OR 1.73; 1.57–1.93). Higher scores were associated with lower age at onset in both cohorts. Conclusions: High GRS increases the risk of familial LOAD and lowers the age at onset, regardless of ethnic group. PMID:28213371

Polygenic risk scores in familial Alzheimer disease.

PubMed

Tosto, Giuseppe; Bird, Thomas D; Tsuang, Debby; Bennett, David A; Boeve, Bradley F; Cruchaga, Carlos; Faber, Kelley; Foroud, Tatiana M; Farlow, Martin; Goate, Alison M; Bertlesen, Sarah; Graff-Radford, Neill R; Medrano, Martin; Lantigua, Rafael; Manly, Jennifer; Ottman, Ruth; Rosenberg, Roger; Schaid, Daniel J; Schupf, Nicole; Stern, Yaakov; Sweet, Robert A; Mayeux, Richard

2017-03-21

To investigate the association between a genetic risk score (GRS) and familial late-onset Alzheimer disease (LOAD) and its predictive value in families multiply affected by the disease. Using data from the National Institute on Aging Genetics Initiative for Late-Onset Alzheimer Disease (National Institute on Aging-Late-Onset Alzheimer's Disease Family Study), mixed regression models tested the association of familial LOAD with a GRS based on single nucleotide polymorphisms (SNPs) previously associated with LOAD. We modeled associations using unweighted and weighted scores with estimates derived from the literature. In secondary models, we adjusted subsequent models for presence of the APOE ε4 allele and further tested the interaction between APOE ε4 and the GRS. We constructed a similar GRS in a cohort of Caribbean Hispanic families multiply affected by LOAD by selecting the SNP with the strongest p value within the same regions. In the NIA-LOAD families, the GRS was significantly associated with LOAD (odds ratio [OR] 1.29; 95% confidence interval 1.21-1.37). The results did not change after adjusting for APOE ε4. In Caribbean Hispanic families, the GRS also significantly predicted LOAD (OR 1.73; 1.57-1.93). Higher scores were associated with lower age at onset in both cohorts. High GRS increases the risk of familial LOAD and lowers the age at onset, regardless of ethnic group. © 2017 American Academy of Neurology.

Discovery of a Three-Layered Atmospheric Structure in Accretion Disks around Stellar-Mass Black Holes

NASA Technical Reports Server (NTRS)

Zhang, S. N.; Zhang, Xiaoling; Sun, Xuejun; Yao, Yangsen; Cui, Wei; Chen, Wan; Wu, Xuebing; Xu, Haiguang

1999-01-01

We have carried out systematic modeling of the X-ray spectra of the Galactic superluminal jet sources GRS 1915+105 and GRO J1655-40, using our newly developed spectral fitting methods. Our results reveal, for the first time, a three-layered structure of the atmosphere in the inner region of the accretion disks. Above the conanonly known, cold and optically thick disk of a blackbody temperature 0.2-0.5 keV, there is a layer of warm gas with a temperature of 1.0-1.5 keV and an optical depth of around 10. Compton scattering of the underlying disk blackbody photons produces the soft X-ray component we comonly observe. Under certain conditions, there is also a much hotter, optically thin corona above the warm layer, characterized by a temperature of 100 keV or higher and an optical depth of unity or less. The corona produces the hard X-ray component typically seen in these sources. We emphasize that the existence of the warm layer seem to be independent of the presence of the hot corona and, therefore, it is not due to irradiation of the disk by hard X-rays from the corona. Our results suggest a striking structural similarity between the accretion disks and the solar atmosphere, which may provide a new stimulus to study the common underlying physical processes operating in these vastly different systems. We also report the first unambiguous detection of an emission line around 6.4 keV in GRO J1655-40, which may allow further constraining of the accretion disk structure. We acknowledge NASA GSFC and MFC for partial financial support. (copyright) 1999: American Astronomical Society. All rights reverved.

The H.E.S.S. Galactic plane survey

NASA Astrophysics Data System (ADS)

H. E. S. S. Collaboration; Abdalla, H.; Abramowski, A.; Aharonian, F.; Benkhali, F. Ait; Angüner, E. O.; Arakawa, M.; Arrieta, M.; Aubert, P.; Backes, M.; Balzer, A.; Barnard, M.; Becherini, Y.; Tjus, J. Becker; Berge, D.; Bernhard, S.; Bernlöhr, K.; Blackwell, R.; Böttcher, M.; Boisson, C.; Bolmont, J.; Bonnefoy, S.; Bordas, P.; Bregeon, J.; Brun, F.; Brun, P.; Bryan, M.; Büchele, M.; Bulik, T.; Capasso, M.; Carrigan, S.; Caroff, S.; Carosi, A.; Casanova, S.; Cerruti, M.; Chakraborty, N.; Chaves, R. C. G.; Chen, A.; Chevalier, J.; Colafrancesco, S.; Condon, B.; Conrad, J.; Davids, I. D.; Decock, J.; Deil, C.; Devin, J.; deWilt, P.; Dirson, L.; Djannati-Ataï, A.; Domainko, W.; Donath, A.; Drury, L. O.'C.; Dutson, K.; Dyks, J.; Edwards, T.; Egberts, K.; Eger, P.; Emery, G.; Ernenwein, J.-P.; Eschbach, S.; Farnier, C.; Fegan, S.; Fernandes, M. V.; Fiasson, A.; Fontaine, G.; Förster, A.; Funk, S.; Füßling, M.; Gabici, S.; Gallant, Y. A.; Garrigoux, T.; Gast, H.; Gaté, F.; Giavitto, G.; Giebels, B.; Glawion, D.; Glicenstein, J. F.; Gottschall, D.; Grondin, M.-H.; Hahn, J.; Haupt, M.; Hawkes, J.; Heinzelmann, G.; Henri, G.; Hermann, G.; Hinton, J. A.; Hofmann, W.; Hoischen, C.; Holch, T. L.; Holler, M.; Horns, D.; Ivascenko, A.; Iwasaki, H.; Jacholkowska, A.; Jamrozy, M.; Jankowsky, D.; Jankowsky, F.; Jingo, M.; Jouvin, L.; Jung-Richardt, I.; Kastendieck, M. A.; Katarzyński, K.; Katsuragawa, M.; Katz, U.; Kerszberg, D.; Khangulyan, D.; Khélifi, B.; King, J.; Klepser, S.; Klochkov, D.; Kluźniak, W.; Komin, Nu.; Kosack, K.; Krakau, S.; Kraus, M.; Krüger, P. P.; Laffon, H.; Lamanna, G.; Lau, J.; Lees, J.-P.; Lefaucheur, J.; Lemière, A.; Lemoine-Goumard, M.; Lenain, J.-P.; Leser, E.; Lohse, T.; Lorentz, M.; Liu, R.; López-Coto, R.; Lypova, I.; Marandon, V.; Malyshev, D.; Marcowith, A.; Mariaud, C.; Marx, R.; Maurin, G.; Maxted, N.; Mayer, M.; Meintjes, P. J.; Meyer, M.; Mitchell, A. M. W.; Moderski, R.; Mohamed, M.; Mohrmann, L.; Morå, K.; Moulin, E.; Murach, T.; Nakashima, S.; de Naurois, M.; Ndiyavala, H.; Niederwanger, F.; Niemiec, J.; Oakes, L.; O'Brien, P.; Odaka, H.; Ohm, S.; Ostrowski, M.; Oya, I.; Padovani, M.; Panter, M.; Parsons, R. D.; Paz Arribas, M.; Pekeur, N. W.; Pelletier, G.; Perennes, C.; Petrucci, P.-O.; Peyaud, B.; Piel, Q.; Pita, S.; Poireau, V.; Poon, H.; Prokhorov, D.; Prokoph, H.; Pühlhofer, G.; Punch, M.; Quirrenbach, A.; Raab, S.; Rauth, R.; Reimer, A.; Reimer, O.; Renaud, M.; de los Reyes, R.; Rieger, F.; Rinchiuso, L.; Romoli, C.; Rowell, G.; Rudak, B.; Rulten, C. B.; Safi-Harb, S.; Sahakian, V.; Saito, S.; Sanchez, D. A.; Santangelo, A.; Sasaki, M.; Schandri, M.; Schlickeiser, R.; Schüssler, F.; Schulz, A.; Schwanke, U.; Schwemmer, S.; Seglar-Arroyo, M.; Settimo, M.; Seyffert, A. S.; Shafi, N.; Shilon, I.; Shiningayamwe, K.; Simoni, R.; Sol, H.; Spanier, F.; Spir-Jacob, M.; Stawarz, Ł.; Steenkamp, R.; Stegmann, C.; Steppa, C.; Sushch, I.; Takahashi, T.; Tavernet, J.-P.; Tavernier, T.; Taylor, A. M.; Terrier, R.; Tibaldo, L.; Tiziani, D.; Tluczykont, M.; Trichard, C.; Tsirou, M.; Tsuji, N.; Tuffs, R.; Uchiyama, Y.; van der Walt, D. J.; van Eldik, C.; van Rensburg, C.; van Soelen, B.; Vasileiadis, G.; Veh, J.; Venter, C.; Viana, A.; Vincent, P.; Vink, J.; Voisin, F.; Völk, H. J.; Vuillaume, T.; Wadiasingh, Z.; Wagner, S. J.; Wagner, P.; Wagner, R. M.; White, R.; Wierzcholska, A.; Willmann, P.; Wörnlein, A.; Wouters, D.; Yang, R.; Zaborov, D.; Zacharias, M.; Zanin, R.; Zdziarski, A. A.; Zech, A.; Zefi, F.; Ziegler, A.; Zorn, J.; Żywucka, N.

2018-04-01

We present the results of the most comprehensive survey of the Galactic plane in very high-energy (VHE) γ-rays, including a public release of Galactic sky maps, a catalog of VHE sources, and the discovery of 16 new sources of VHE γ-rays. The High Energy Spectroscopic System (H.E.S.S.) Galactic plane survey (HGPS) was a decade-long observation program carried out by the H.E.S.S. I array of Cherenkov telescopes in Namibia from 2004 to 2013. The observations amount to nearly 2700 h of quality-selected data, covering the Galactic plane at longitudes from ℓ = 250° to 65° and latitudes |b|≤ 3°. In addition to the unprecedented spatial coverage, the HGPS also features a relatively high angular resolution (0.08° ≈ 5 arcmin mean point spread function 68% containment radius), sensitivity (≲1.5% Crab flux for point-like sources), and energy range (0.2-100 TeV). We constructed a catalog of VHE γ-ray sources from the HGPS data set with a systematic procedure for both source detection and characterization of morphology and spectrum. We present this likelihood-based method in detail, including the introduction of a model component to account for unresolved, large-scale emission along the Galactic plane. In total, the resulting HGPS catalog contains 78 VHE sources, of which 14 are not reanalyzed here, for example, due to their complex morphology, namely shell-like sources and the Galactic center region. Where possible, we provide a firm identification of the VHE source or plausible associations with sources in other astronomical catalogs. We also studied the characteristics of the VHE sources with source parameter distributions. 16 new sources were previously unknown or unpublished, and we individually discuss their identifications or possible associations. We firmly identified 31 sources as pulsar wind nebulae (PWNe), supernova remnants (SNRs), composite SNRs, or gamma-ray binaries. Among the 47 sources not yet identified, most of them (36) have possible associations with cataloged objects, notably PWNe and energetic pulsars that could power VHE PWNe. The source catalog is available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (http://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/612/A1

Search for ultra high energy gamma-rays from various sources

NASA Technical Reports Server (NTRS)

Dzikowski, T.; Gawin, J.; Grochalska, B.; Korejwo, J.; Wdowczyk, J.

1985-01-01

The hypothesis that there exists an excess of showers from the Galactic plane on the level 1 to 2% at energies just above 10 to the 16th power eV is explored. The excess shower from the Galactic plane seems to be very similar in properties to excess showers from the point sources/flat spectrum, deficit of low energy muons. Those facts suggest that the excess from the Galactic plane are probably due to summing up of the contribution from individual point sources. That in turn suggest that those sources are rather numerous.

Velocity and Vorticity Measurements of Jupiter's Great Red Spot Using Automated Cloud Feature Trackers

NASA Astrophysics Data System (ADS)

Choi, David S.; Banfield, D.; Gierasch, P. J.; Showman, A. P.

2006-09-01

We have produced mosaics of the Great Red Spot (GRS) using images taken by Galileo in May 2000, and have measured the winds of the GRS using an automated algorithm that does not require manual cloud tracking. Our technique yields a high-density, regular grid of wind velocity vectors that is advantageous over a limited number of scattered wind vectors that result from manual cloud tracking. The high-velocity collar of the GRS is clearly seen in our velocity vector map, and highest wind velocities are measured to be 166.4 m/s. The high resolution of the mosaics have also enabled us to map turbulent eddies inside the chaotic central region of the GRS, similar to those mapped by Sada et al. (1996) and Vasavada et al. (1998). We have also discovered a narrow ring of cyclonic vorticity that surrounds the main anti-cyclonic high-velocity collar. This narrow ring appears to correspond to a ring surrounding the GRS that is bright in 5-um (Terrile et al. 1979). It appears that this cyclonic ring is not a transient feature of the GRS, as we have discovered it in a re-analysis of Galileo images from 1996, first analyzed by Vasavada et al. (1998). Cyclonic rings around Jovian anti-cyclones have also appeared in numerical modeling studies by Showman (2006). We also calculate how absolute vorticity changes as a function of latitude along particle trajectories around the GRS and compare these measurements to similar ones performed by Dowling & Ingersoll (1988) using Voyager data. From this comparison, we show no dramatic evolution in the structure of the GRS since the Voyager era. This work was supported by NASA Planetary Atmospheres grants to APS and PJG, along with support from Cornell Presidential Research Scholars.

Saturated fat intake modulates the association between a genetic risk score of obesity and BMI in two US populations

PubMed Central

Casas-Agustench, Patricia; Arnett, Donna K.; Smith, Caren E.; Lai, Chao-Qiang; Parnell, Laurence D.; Borecki, Ingrid B.; Frazier-Wood, Alexis C.; Allison, Matthew; Chen, Yii-Der Ida; Taylor, Kent D.; Rich, Stephen S.; Rotter, Jerome I.; Lee, Yu-Chi; Ordovás, José M.

2014-01-01

Combining multiple genetic variants related to obesity into a genetic risk score (GRS) might improve identification of individuals at risk of developing obesity. Moreover, characterizing gene-diet interactions is a research challenge to establish dietary recommendations to individuals with higher predisposition to obesity. Our objective was to analyze the association between an obesity GRS and BMI in the Genetics of Lipid Lowering Drugs and Diet Network (GOLDN) population, focusing on gene-diet interactions with total fat and saturated fatty acid (SFA) intake and to replicate findings in Multi-Ethnic Study of Atherosclerosis (MESA) population. Cross-sectional analyses included 783 US Caucasian participants from GOLDN and 2035 from MESA. Dietary intakes were estimated with validated food frequency questionnaires. Height and weight were measured. A weighted GRS was calculated on the basis of 63 obesity-associated variants. Multiple linear regression models adjusted by potential confounders were used to examine gene-diet interactions between dietary intake (total fat and SFA) and the obesity GRS in determining BMI. Significant interactions were found between total fat intake and the obesity GRS using these variables as continuous for BMI (P for interaction=0.010, 0.046, and 0.002 in GOLDN, MESA and meta-analysis, respectively). These association terms were stronger when assessing interactions between SFA intake and GRS for BMI (P for interaction=0.005, 0.018, and <0.001 in GOLDN, MESA and meta-analysis, respectively). SFA intake interacts with an obesity GRS in modulating BMI in two US populations. Although to determine the causal direction requires further investigation, these findings suggest that potential dietary recommendations to reduce BMI effectively in populations with high obesity GRS would be to reduce total fat intake mainly by limiting SFAs. PMID:24794412

Genetic risk score of common genetic variants for impaired fasting glucose and newly diagnosed type 2 diabetes influences oxidative stress.

PubMed

Kim, Minjoo; Kim, Minkyung; Huang, Limin; Jee, Sun Ha; Lee, Jong Ho

2018-05-18

We tested the hypothesis that the cumulative effects of common genetic variants related to elevated fasting glucose are collectively associated with oxidative stress. Using 25 single nucleotide polymorphisms (SNPs), a weighted genetic risk score (wGRS) was constructed by summing nine risk alleles based on nominal significance and a consistent effect direction in 1,395 controls and 718 patients with impaired fasting glucose (IFG) or newly diagnosed type 2 diabetes. All the participants were divided into the following three groups: low-wGRS, middle-wGRS, and high-wGRS groups. Among the nine SNPs, five SNPs were significantly associated with IFG and type 2 diabetes in this Korean population. wGRS was significantly associated with increased IFG and newly diagnosed type 2 diabetes (p = 6.83 × 10 -14 , odds ratio = 1.839) after adjusting for confounding factors. Among the IFG and type 2 diabetes patients, the fasting serum glucose and HbA 1c levels were significantly higher in the high-wGRS group than in the other groups. The urinary 8-epi-PGF 2α and malondialdehyde concentrations were significantly higher in the high-wGRS group than in the other groups. Moreover, general population-level instrumental variable estimation (using wGRS as an instrument) strengthened the causal effect regarding the largely adverse influence of high levels of fasting serum glucose on markers of oxidative stress in the Korean population. Thus, the combination of common genetic variants with small effects on IFG and newly diagnosed type 2 diabetes are significantly associated with oxidative stress.

Genetic predisposition to coronary heart disease and stroke using an additive genetic risk score: A population-based study in Greece

PubMed Central

Yiannakouris, N.; Katsoulis, M.; Dilis, V.; Parnell, L.D.; Trichopoulos, D.; Ordovas, J.M.; Trichopoulou, A.

2012-01-01

Objective To determine the extent to which the risk for incident coronary heart disease (CHD) increases in relation to a genetic risk score (GRS) that additively integrates the influence of high-risk alleles in nine documented single nucleotide polymorphisms (SNPs) for CHD, and to examine whether this GRS also predicts incident stroke. Methods Genotypes at nine CHD-relevant SNPs were determined in 494 cases of incident CHD, 320 cases of incident stroke and 1345 unaffected controls drawn from the population-based Greek component of the European Prospective Investigation into Cancer and nutrition (EPIC) cohort. An additive GRS was calculated for each study participant by adding one unit for the presence of each high-risk allele multiplied by the estimated effect size of that allele in the discovery samples. Statistical analysis was performed using logistic regression. Results The GRS was significantly associated with the incidence of CHD where the odds of CHD incidence in the highest quintile of the GRS were 1.74 times higher (95% confidence interval [CI] = 1.25–2.43, p for trend = 0.0004), compared to the lowest quintile. With respect to stroke, a weaker and non-significant positive association with GRS was apparent as the odds of stroke incidence in the highest quintile of the GRS were 1.36 times higher (95% CI = 0.90–2.06, p for trend = 0.188), compared to the lowest quintile. Conclusion A GRS relying on nine documented “CHD-specific” SNPs is significantly predictive of CHD but it was not found to be statistically significantly associated with incident stroke. PMID:22429504

The 2008 Passage of Jupiter's Great Red Spot and Oval BA as Observed from Hubble/WFPC2

NASA Technical Reports Server (NTRS)

Simon-Miller, Amy A.; Chanover, N. J.; Orton, G. S.; Tsavaris, I.

2008-01-01

Hubble Space Telescope data of the passage of Jupiter's Great Red Spot (GRS) and Oval BA were acquired on May 15, June 28 (near closest approach), and July 8. Wind fields were measured from Wide Field Planetary Camera 2 (WFPC2) data with 10-hour separations before and after closest approach, and within the GRS with 40-minute separations on all three dates. Color information was also derived using 8 narrowband WFPC2 filters from 343 to 673-nm on all three dates. We will present the results of principal components and wind analyses and discuss unique features seen in this data set. In addition, we will highlight any changes observed in the GRS, Oval BA and their surroundings as a result of the passage, including the movement of a smaller red anticyclone from west of the GRS, around its southern periphery, and to the east of the GRS.

INFLUENCE OF THE GALACTIC GRAVITATIONAL FIELD ON THE POSITIONAL ACCURACY OF EXTRAGALACTIC SOURCES

DOE Office of Scientific and Technical Information (OSTI.GOV)

Larchenkova, Tatiana I.; Lutovinov, Alexander A.; Lyskova, Natalya S.

We investigate the influence of random variations of the Galactic gravitational field on the apparent celestial positions of extragalactic sources. The basic statistical characteristics of a stochastic process (first-order moments, an autocorrelation function and a power spectral density) are used to describe a light ray deflection in a gravitational field of randomly moving point masses as a function of the source coordinates. We map a 2D distribution of the standard deviation of the angular shifts in positions of distant sources (including reference sources of the International Celestial Reference Frame) with respect to their true positions. For different Galactic matter distributionsmore » the standard deviation of the offset angle can reach several tens of μ as (microarcsecond) toward the Galactic center, decreasing down to 4–6 μ as at high galactic latitudes. The conditional standard deviation (“jitter”) of 2.5 μ as is reached within 10 years at high galactic latitudes and within a few months toward the inner part of the Galaxy. The photometric microlensing events are not expected to be disturbed by astrometric random variations anywhere except the inner part of the Galaxy as the Einstein–Chvolson times are typically much shorter than the jittering timescale. While a jitter of a single reference source can be up to dozens of μ as over some reasonable observational time, using a sample of reference sources would reduce the error in relative astrometry. The obtained results can be used for estimating the physical upper limits on the time-dependent accuracy of astrometric measurements.« less

The Fermi Large Area Telescope Thrid Gamma-ray Source Catalog

NASA Astrophysics Data System (ADS)

Stephens, Thomas E.; Ballet, Jean; Burnett, Toby; Cavazzuti, Elisabetta; Digel, Seth William; Fermi LAT Collaboration

2015-01-01

We present an overview of the third Fermi Large Area Telescope source catalog (3FGL) of sources in the 100 MeV - 300 GeV range. Based on the first four years of science data from the Fermi Gamma-ray Space Telescope mission, it is the deepest yet in this energy range. Relative to the 2FGL catalog (Nolan et al. 2012, ApJS 199, 31), the 3FGL catalog incorporates twice as much data as well as a number of analysis improvements, including improved calibrations at the event reconstruction level, an updated model for Galactic diffuse gamma-ray emission, a refined procedure for source detection, and improved methods for associating LAT sources with potential counterparts at other wavelengths. The 3FGL catalog includes 3033 sources, with source location regions, spectral properties, and monthly light curves for each. For approximately one-third of the sources we have not found counterparts at other wavelengths. More than 1100 of the identified or associated sources are active galaxies of the blazar class; several other classes of non-blazar active galaxies are also represented in the 3FGL. Pulsars represent the largest Galactic source class. From source counts of Galactic sources we estimate the contribution of unresolved sources to the Galactic diffuse emission.

36 CFR § 1227.14 - How do I obtain copies of the GRS?

Code of Federal Regulations, 2013 CFR

2013-07-01

... Administration, Modern Records Programs (NWM), 8601 Adelphi Road, College Park, MD 20740-6001, phone number (301... GRS? § 1227.14 Section § 1227.14 Parks, Forests, and Public Property NATIONAL ARCHIVES AND RECORDS ADMINISTRATION RECORDS MANAGEMENT GENERAL RECORDS SCHEDULES § 1227.14 How do I obtain copies of the GRS? (a) The...

A model of the 8-25 micron point source infrared sky

NASA Technical Reports Server (NTRS)

Wainscoat, Richard J.; Cohen, Martin; Volk, Kevin; Walker, Helen J.; Schwartz, Deborah E.

1992-01-01

We present a detailed model for the IR point-source sky that comprises geometrically and physically realistic representations of the Galactic disk, bulge, stellar halo, spiral arms (including the 'local arm'), molecular ring, and the extragalactic sky. We represent each of the distinct Galactic components by up to 87 types of Galactic source, each fully characterized by scale heights, space densities, and absolute magnitudes at BVJHK, 12, and 25 microns. The model is guided by a parallel Monte Carlo simulation of the Galaxy at 12 microns. The content of our Galactic source table constitutes a good match to the 12 micron luminosity function in the simulation, as well as to the luminosity functions at V and K. We are able to produce differential and cumulative IR source counts for any bandpass lying fully within the IRAS Low-Resolution Spectrometer's range (7.7-22.7 microns as well as for the IRAS 12 and 25 micron bands. These source counts match the IRAS observations well. The model can be used to predict the character of the point source sky expected for observations from IR space experiments.

Is There a Dark Matter Signal in the Galactic Positron Annihilation Radiation?

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lingenfelter, R. E.; Rothschild, R. E.; Higdon, J. C.

2009-07-17

Assuming Galactic positrons do not go far before annihilating, a difference between the observed 511 keV annihilation flux distribution and that of positron production, expected from beta{sup +} decay in Galactic iron nucleosynthesis, was evoked as evidence of a new source and signal of dark matter. We show, however, that the dark matter sources cannot account for the observed positronium fraction without extensive propagation. Yet with such propagation, standard nucleosynthetic sources can fully account for the spatial differences and positronium fraction, leaving no new signal for dark matter to explain.

Genetic risk scores and family history as predictors of schizophrenia in Nordic registers.

PubMed

Lu, Y; Pouget, J G; Andreassen, O A; Djurovic, S; Esko, T; Hultman, C M; Metspalu, A; Milani, L; Werge, T; Sullivan, P F

2018-05-01

Family history is a long-standing and readily obtainable risk factor for schizophrenia (SCZ). Low-cost genotyping technologies have enabled large genetic studies of SCZ, and the results suggest the utility of genetic risk scores (GRS, direct assessments of inherited common variant risk). Few studies have evaluated family history and GRS simultaneously to ask whether one can explain away the other. We studied 5959 SCZ cases and 8717 controls from four Nordic countries. All subjects had family history data from national registers and genome-wide genotypes that were processed through the quality control procedures used by the Psychiatric Genomics Consortium. Using external training data, GRS were estimated for SCZ, bipolar disorder (BIP), major depression, autism, educational attainment, and body mass index. Multivariable modeling was used to estimate effect sizes. Using harmonized genomic and national register data from Denmark, Estonia, Norway, and Sweden, we confirmed that family history of SCZ and GRS for SCZ and BIP were risk factors for SCZ. In a joint model, the effects of GRS for SCZ and BIP were essentially unchanged, and the effect of family history was attenuated but remained significant. The predictive capacity of a model including GRS and family history neared the minimum for clinical utility. Combining national register data with measured genetic risk factors represents an important investigative approach for psychotic disorders. Our findings suggest the potential clinical utility of combining GRS and family history for early prediction and diagnostic improvements.

Disclosing genetic risk for coronary heart disease: effects on perceived personal control and genetic counseling satisfaction.

PubMed

Robinson, C L; Jouni, H; Kruisselbrink, T M; Austin, E E; Christensen, K D; Green, R C; Kullo, I J

2016-02-01

We investigated whether disclosure of coronary heart disease (CHD) genetic risk influences perceived personal control (PPC) and genetic counseling satisfaction (GCS). Participants (n = 207, age: 45-65 years) were randomized to receive estimated 10-year risk of CHD based on a conventional risk score (CRS) with or without a genetic risk score (GRS). Risk estimates were disclosed by a genetic counselor who also reviewed how GRS altered risk in those randomized to CRS+GRS. Each participant subsequently met with a physician and then completed surveys to assess PPC and GCS. Participants who received CRS+GRS had higher PPC than those who received CRS alone although the absolute difference was small (25.2 ± 2.7 vs 24.1 ± 3.8, p = 0.04). A greater proportion of CRS+GRS participants had higher GCS scores (17.3 ± 5.3 vs 15.9 ± 6.3, p = 0.06). In the CRS+GRS group, PPC and GCS scores were not correlated with GRS. Within both groups, PPC and GCS scores were similar in patients with or without family history (p = NS). In conclusion, patients who received their genetic risk of CHD had higher PPC and tended to have higher GCS. Our findings suggest that disclosure of genetic risk of CHD together with conventional risk estimates is appreciated by patients. Whether this results in improved outcomes needs additional investigation. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Increasing insulin resistance accentuates the effect of triglyceride-associated loci on serum triglycerides during 5 years[S

PubMed Central

Justesen, Johanne M.; Andersson, Ehm A.; Allin, Kristine H.; Sandholt, Camilla H.; Jørgensen, Torben; Linneberg, Allan; Jørgensen, Marit E.; Hansen, Torben; Pedersen, Oluf; Grarup, Niels

2016-01-01

Blood concentrations of triglycerides are influenced by genetic factors as well as a number of environmental factors, including adiposity and glucose homeostasis. The aim was to investigate the association between a serum triglyceride weighted genetic risk score (wGRS) and changes in fasting serum triglyceride level over 5 years and to test whether the effect of the wGRS was modified by 5 year changes of adiposity, insulin resistance, and lifestyle factors. A total of 3,474 nondiabetic individuals from the Danish Inter99 cohort participated in both the baseline and 5 year follow-up physical examinations and had information on the wGRS comprising 39 genetic variants. In a linear regression model adjusted for age, sex, and baseline serum triglyceride, the wGRS was associated with increased serum triglyceride levels over 5 years [per allele effect = 1.3% (1.0–1.6%); P = 1.0 × 10−17]. This triglyceride-increasing effect of the wGRS interacted with changes in insulin resistance (Pinteraction = 1.5 × 10−6). This interaction indicated that the effect of the wGRS was stronger in individuals who became more insulin resistant over 5 years. In conclusion, our findings suggest that increased genetic risk load is associated with a larger increase in fasting serum triglyceride levels in nondiabetic individuals during 5 years of follow-up. This effect of the wGRS is accentuated by increasing insulin resistance. PMID:27777317

Increasing insulin resistance accentuates the effect of triglyceride-associated loci on serum triglycerides during 5 years.

PubMed

Justesen, Johanne M; Andersson, Ehm A; Allin, Kristine H; Sandholt, Camilla H; Jørgensen, Torben; Linneberg, Allan; Jørgensen, Marit E; Hansen, Torben; Pedersen, Oluf; Grarup, Niels

2016-12-01

Blood concentrations of triglycerides are influenced by genetic factors as well as a number of environmental factors, including adiposity and glucose homeostasis. The aim was to investigate the association between a serum triglyceride weighted genetic risk score (wGRS) and changes in fasting serum triglyceride level over 5 years and to test whether the effect of the wGRS was modified by 5 year changes of adiposity, insulin resistance, and lifestyle factors. A total of 3,474 nondiabetic individuals from the Danish Inter99 cohort participated in both the baseline and 5 year follow-up physical examinations and had information on the wGRS comprising 39 genetic variants. In a linear regression model adjusted for age, sex, and baseline serum triglyceride, the wGRS was associated with increased serum triglyceride levels over 5 years [per allele effect = 1.3% (1.0-1.6%); P = 1.0 × 10 -17 ]. This triglyceride-increasing effect of the wGRS interacted with changes in insulin resistance (P interaction = 1.5 × 10 -6 ). This interaction indicated that the effect of the wGRS was stronger in individuals who became more insulin resistant over 5 years. In conclusion, our findings suggest that increased genetic risk load is associated with a larger increase in fasting serum triglyceride levels in nondiabetic individuals during 5 years of follow-up. This effect of the wGRS is accentuated by increasing insulin resistance. Copyright © 2016 by the American Society for Biochemistry and Molecular Biology, Inc.

Fatty acid profiles, meat quality, and sensory attributes of organic versus conventional dairy beef steers.

PubMed

Bjorklund, E A; Heins, B J; Dicostanzo, A; Chester-Jones, H

2014-03-01

Meat from Holstein and crossbred organic and conventional dairy steers were evaluated and compared for fatty acid profiles, meat quality, sensory attributes, and consumer acceptance. Bull calves (n=49) were randomly assigned to 1 of 3 replicated groups: conventional (CONV), organic (ORG, pasture + concentrate), or grass-fed organic (GRS) and were born at the University of Minnesota West Central Research and Outreach Center (Morris, MN) between March and May 2011. The CONV steers (n=16) were fed a diet that contained 80% concentrate and 20% forage, and ORG steers (n=16) were fed a diet of organic corn, organic corn silage, and organic protein supplement. Furthermore, ORG steers consumed at least 30% of diet dry matter of high-quality organic pasture during the grazing season. The GRS steers (n=17) consumed 100% forage from pasture during the grazing season and high-quality hay or hay silage during the nongrazing season. The ORG steers had fat that was greater in oleic acid (C18:1) than the GRS and CONV steers (47.1, 36.1, and 39.9%, respectively). The GRS steers (21.9%) were lower for monounsaturated fat than the ORG (42.1%) and CONV (40.4%) steers. Furthermore, the GRS steers tended to have greater n-3 fat and had lower n-6 fat than the ORG and CONV steers. Consequently, the GRS (1.4%) steers had a lower n-6-to-n-3 fat ratio than the ORG (12.9%) and CONV (10.0%) steers. The GRS (2.6 kg) steers had steaks that were not different for Warner-Bratzler shear force than ORG (2.3 kg) steaks; however, the GRS steaks tended to have greater shear force than the CONV (2.0 kg) steaks. The 3 steer group had steaks that were not different for color brightness (L*; 0 = black and 100 = white) and yellowness/blueness (b*; positive values = yellow and negative values = blue) values; however, the GRS (10.5) steaks had lower redness/greenness (a*; positive values = red and negative values = green) values than CONV (14.5) steaks. For sensory attributes (0- to 120-point scale), no differences were observed for ORG (71.3) and CONV (69.2) steers for overall consumer liking of the beef; however, the GRS (56.3) steers had the lowest overall liking among beef consumers. The ORG (73.3) steers had greater flavor liking than the GRS (56.8) and CONV (69.2) steers. Conversely, the GRS (6.3) steers had the highest scores for off-flavor (0- to 20-point scale) compared with the ORG (3.9) and CONV (4.1) steers. The results of the current study suggest that a potential market may exist for organic grass-fed dairy steers in the United States, but quality and consistency of the beef needs to be improved. Copyright © 2014 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.

Powerful, Rotating Disk Winds from Stellar-mass Black Holes

NASA Astrophysics Data System (ADS)

Miller, J. M.; Fabian, A. C.; Kaastra, J.; Kallman, T.; King, A. L.; Proga, D.; Raymond, J.; Reynolds, C. S.

2015-12-01

We present an analysis of ionized X-ray disk winds found in the Fe K band of four stellar-mass black holes observed with Chandra, including 4U 1630-47, GRO J1655-40, H 1743-322, and GRS 1915+105. High-resolution photoionization grids were generated in order to model the data. Third-order gratings spectra were used to resolve complex absorption profiles into atomic effects and multiple velocity components. The Fe xxv line is found to be shaped by contributions from the intercombination line (in absorption), and the Fe xxvi line is detected as a spin-orbit doublet. The data require 2-3 absorption zones, depending on the source. The fastest components have velocities approaching or exceeding 0.01c, increasing mass outflow rates and wind kinetic power by orders of magnitude over prior single-zone models. The first-order spectra require re-emission from the wind, broadened by a degree that is loosely consistent with Keplerian orbital velocities at the photoionization radius. This suggests that disk winds are rotating with the orbital velocity of the underlying disk, and provides a new means of estimating launching radii—crucial to understanding wind driving mechanisms. Some aspects of the wind velocities and radii correspond well to the broad-line region in active galactic nuclei (AGNs), suggesting a physical connection. We discuss these results in terms of prevalent models for disk wind production and disk accretion itself, and implications for massive black holes in AGNs.

The Cosmic Battery Revisited

NASA Technical Reports Server (NTRS)

Contopoulos, Ioannis; Kazanas, Demosthenes; Christodoulos, Dimistris M.

2007-01-01

We reinvestigate the generation and accumulation of magnetic flux in optically thin accretion flows around active gravitating objects. The source of the magnetic field is the azimuthal electric current associated with the Poynting-Robertson drag on the electrons of the accreting plasma. This current generates magnetic field loops which open up because of the differential rotation of the flow. We show through simple numerical simulations that what regulates the generation and accumulation of magnetic flux near the center is the value of the plasma conductivity. Although the conductivity is usually considered to be effectively infinite for the fully ionized plasmas expected near the inner edge of accretion disks, the turbulence of those plasmas may actually render them much less conducting due to the presence of anomalous resistivity. We have discovered that if the resistivity is sufficiently high throughout the turbulent disk while it is suppressed interior to its inner edge, an interesting steady-state process is established: accretion carries and accumulates magnetic flux of one polarity inside the inner edge of the disk, whereas magnetic diffusion releases magnetic flux of the opposite polarity to large distances. In this scenario, magnetic flux of one polarity grows and accumulates at a steady rate in the region inside the inner edge and up to the point of equipartition when it becomes dynamically important. We argue that this inward growth and outward expulsion of oppositely-directed magnetic fields that we propose may account for the approx. 30 min cyclic variability observed in the galactic microquasar GRS1915+105.

Galactic plane gamma-radiation

NASA Technical Reports Server (NTRS)

Hartman, R. C.; Kniffen, D. A.; Thompson, D. J.; Fichtel, C. E.; Ogelman, H. B.; Tumer, T.; Ozel, M. E.

1979-01-01

Analysis of the SAS 2 data together with the COS B results shows that the distribution of galactic gamma-radiation has several similarities to that of other large-scale tracers of galactic structure. The radiation is primarily confined to a thin disc which exhibits offsets from b = 0 degrees similar to warping at radio frequencies. The principal distinction of the gamma-radiation is a stronger contrast in intensity between the region from 310 to 45 degrees in longitude and the regions away from the center that can be attributed to a variation in cosmic-ray density as a function of position in Galaxy. The diffuse galactic gamma-ray energy spectrum shows no significant variation in direction, and the spectrum seen along the plane is the same as that for the galactic component of the gamma-radiation at high altitudes. The uniformity of the galactic gamma-ray spectrum, the smooth decrease in intensity as a function of altitude, and the absence of any galactic gamma-ray sources at high altitudes indicate a diffuse origin for bulk of the galactic gamma-radiation rather than a collection of localized sources.

Cardiovascular Genetic Risk Testing for Targeting Statin Therapy in the Primary Prevention of Atherosclerotic Cardiovascular Disease: A Cost-Effectiveness Analysis.

PubMed

Jarmul, Jamie; Pletcher, Mark J; Hassmiller Lich, Kristen; Wheeler, Stephanie B; Weinberger, Morris; Avery, Christy L; Jonas, Daniel E; Earnshaw, Stephanie; Pignone, Michael

2018-04-01

It is unclear whether testing for novel risk factors, such as a cardiovascular genetic risk score (cGRS), improves clinical decision making or health outcomes when used for targeting statin initiation in the primary prevention of atherosclerotic cardiovascular disease (ASCVD). Our objective was to estimate the cost-effectiveness of cGRS testing to inform clinical decision making about statin initiation in individuals with low-to-intermediate (2.5%-7.5%) 10-year predicted risk of ASCVD. We evaluated the cost-effectiveness of testing for a 27-single-nucleotide polymorphism cGRS comparing 4 test/treat strategies: treat all, treat none, test/treat if cGRS is high, and test/treat if cGRS is intermediate or high. We tested a set of clinical scenarios of men and women, aged 45 to 65 years, with 10-year ASCVD risks between 2.5% and 7.5%. Our primary outcome measure was cost per quality-adjusted life-year gained. Under base case assumptions for statin disutility and cost, the preferred strategy is to treat all patients with ASCVD risk >2.5% without cGRS testing. For certain clinical scenarios, such as a 57-year-old man with a 10-year ASCVD risk of 7.5%, cGRS testing can be cost-effective under a limited set of assumptions; for example, when statins cost $15 per month and statin disutility is 0.013 (ie, willing to trade 3 months of life in perfect health to avoid 20 years of statin therapy), the preferred strategy (using a willingness-to-pay threshold of $50 000 per quality-adjusted life-year gained) is to test and treat if cGRS is intermediate or high. Overall, the results were not sensitive to assumptions about statin efficacy and harms. Testing for a 27-single-nucleotide polymorphism cGRS is generally not a cost-effective approach for targeting statin therapy in the primary prevention of ASCVD for low- to intermediate-risk patients. © 2018 American Heart Association, Inc.

A Multi-Locus Genetic Risk Score for Primary Open-Angle Glaucoma (POAG) Variants Is Associated with POAG Risk in a Mediterranean Population: Inverse Correlations with Plasma Vitamin C and E Concentrations

PubMed Central

Ortega-Azorin, Carolina; Asensio-Marquez, Eva M.; Garcia-Medina, Jose J.; Pinazo-Duran, Maria D.; Coltell, Oscar; Ordovas, Jose M.

2017-01-01

Primary open-angle glaucoma (POAG) is a leading cause of blindness worldwide. The genetics of POAG are complex, and population-specific effects have been reported. Although many polymorphisms associated with POAG risk have been reported, few studies have analyzed their additive effects. We investigated, in a southern European Mediterranean population, the association between relevant POAG polymorphisms, identified by initial genome-wide association studies (GWASs) and POAG risk, both separately and as an aggregated multi-locus genetic risk score (GRS). Also, bearing in mind that oxidative stress is a factor increasingly recognized in the pathogenesis of POAG, we analyzed the potential association of the GRS with plasma concentrations of antioxidant vitamins (C and E). We carried out a case–control study including 391 POAG cases and 383 healthy controls, and analyzed four genetic polymorphisms (rs4656461-TMCO1, rs4236601-CAV1/CAV2, rs2157719-CDKN2B-AS1 and rs3088440-CDKN2A). An unweighted GRS including the four non-linked polymorphisms was constructed. A strong association between the GRS and POAG risk was found. When three categories of the GRS were considered, subjects in the top category of the GRS were 2.92 (95% confidence interval (CI): 1.79–4.77) times more likely to have POAG compared with participants in the bottom category (p < 0.001). Moreover, the GRS was inversely correlated with plasma vitamin C (p = 0.002) and vitamin E (p = 0.001) concentrations, even after additional adjustment for POAG status. In conclusion, we have found a strong association between the GRS and POAG risk in this Mediterranean population. While the additional correlation found between GRS and low levels of vitamins C and E does not indicated a causal relationship, it does suggest the need for new and deeper research into the effects of oxidative stress as a potential mechanism for those associations. PMID:29104244

Gravitational Reference Sensor Front-End Electronics Simulator for LISA

NASA Astrophysics Data System (ADS)

Meshksar, Neda; Ferraioli, Luigi; Mance, Davor; ten Pierick, Jan; Zweifel, Peter; Giardini, Domenico; ">LISA Pathfinder colaboration, Searches for point sources in the Galactic Center region

NASA Astrophysics Data System (ADS)

di Mauro, Mattia; Fermi-LAT Collaboration

2017-01-01

Several groups have demonstrated the existence of an excess in the gamma-ray emission around the Galactic Center (GC) with respect to the predictions from a variety of Galactic Interstellar Emission Models (GIEMs) and point source catalogs. The origin of this excess, peaked at a few GeV, is still under debate. A possible interpretation is that it comes from a population of unresolved Millisecond Pulsars (MSPs) in the Galactic bulge. We investigate the detection of point sources in the GC region using new tools which the Fermi-LAT Collaboration is developing in the context of searches for Dark Matter (DM) signals. These new tools perform very fast scans iteratively testing for additional point sources at each of the pixels of the region of interest. We show also how to discriminate between point sources and structural residuals from the GIEM. We apply these methods to the GC region considering different GIEMs and testing the DM and MSPs intepretations for the GC excess. Additionally, we create a list of promising MSP candidates that could represent the brightest sources of a MSP bulge population.

Molecular and Cellular Designs of Insect Taste Receptor System

PubMed Central

Isono, Kunio; Morita, Hiromi

2010-01-01

The insect gustatory receptors (GRs) are members of a large G-protein coupled receptor family distantly related to the insect olfactory receptors. They are phylogenetically different from taste receptors of most other animals. GRs are often coexpressed with other GRs in single receptor neurons. Taste receptors other than GRs are also expressed in some neurons. Recent molecular studies in the fruitfly Drosophila revealed that the insect taste receptor system not only covers a wide ligand spectrum of sugars, bitter substances or salts that are common to mammals but also includes reception of pheromone and somatosensory stimulants. However, the central mechanism to perceive and discriminate taste information is not yet elucidated. Analysis of the primary projection of taste neurons to the brain shows that the projection profiles depend basically on the peripheral locations of the neurons as well as the GRs that they express. These results suggest that both peripheral and central design principles of insect taste perception are different from those of olfactory perception. PMID:20617187

Contact chemosensation of phytochemicals by insect herbivores

PubMed Central

Burse, Antje

2017-01-01

Contact chemosensation, or tasting, is a complex process governed by nonvolatile phytochemicals that tell host-seeking insects whether they should accept or reject a plant. During this process, insect gustatory receptors (GRs) contribute to deciphering a host plant's metabolic code. GRs recognise many different classes of nonvolatile compounds; some GRs are likely to be narrowly tuned and others, broadly tuned. Although primary and/or secondary plant metabolites influence the insect's feeding choice, their decoding by GRs is challenging, because metabolites in planta occur in complex mixtures that have additive or inhibitory effects; in diverse forms composed of structurally unrelated molecules; and at different concentrations depending on the plant species, its tissue and developmental stage. Future studies of the mechanism of insect herbivore GRs will benefit from functional characterisation taking into account the spatio-temporal dynamics and diversity of the plant's metabolome. Metabolic information, in turn, will help to elucidate the impact of single ligands and complex natural mixtures on the insect's feeding choice. PMID:28485430

Real-time detecting gelatinases activity in living cells by FRET imaging

NASA Astrophysics Data System (ADS)

Yang, Jie; Zhang, Zhihong; Liu, Bifeng; Luo, Qingming

2006-01-01

Degradation of the extracellular matrix by Matrix metalloproteinases (MMPs) not only enhances tumor invasion, but also affects tumor cell behaviour and leads to cancer progression. To monitor gelatinases (contain MMP2 and MMP9) activity in living cells, we constructed a vector that encoded a gelatinases recognition site (GRS) between citrine (mutation of EYFP Q69M) in N terminal and ECFP in C terminal. Because Gelatinases are secretory proteins and act outside of cell, an expressing vector displayed the fusion protein on cellular surface was used for this FRET gene probe. On expression of YFP-GRS-ECFP in MCF-7 cells that expressed no gelatinases, we were able to observe the efficient transfer of energy from excited ECFP to YFP within the YFP-GRS-ECFP molecule. However, the fusion protein YFP-GRS-ECFP was expressed in MDA-MB 453s cell line with high secretory gelatinases, so YFP-GRS-ECFP was cleaved by gelatinases, no such transfer of energy was detected and fluorescence signal disappeared in YFP channel since YFP protein was cut down. Moreover, Doxycycline, a MMP inhibitor, could make FRET signal increase and fluorescence signal appeared in YFP channel. Thus, the FRET probe YFP-GRS-ECFP can sensitively and reliably monitor gelatinases activation in living cells and can be used for screening MMP inhibitors.

Emergency medicine resident crisis resource management ability: a simulation-based longitudinal study

PubMed Central

Clarke, Samuel; Horeczko, Timothy; Carlisle, Matthew; Barton, Joseph D.; Ng, Vivienne; Al-Somali, Sameerah; Bair, Aaron E.

2014-01-01

Background Simulation has been identified as a means of assessing resident physicians’ mastery of technical skills, but there is a lack of evidence for its utility in longitudinal assessments of residents’ non-technical clinical abilities. We evaluated the growth of crisis resource management (CRM) skills in the simulation setting using a validated tool, the Ottawa Crisis Resource Management Global Rating Scale (Ottawa GRS). We hypothesized that the Ottawa GRS would reflect progressive growth of CRM ability throughout residency. Methods Forty-five emergency medicine residents were tracked with annual simulation assessments between 2006 and 2011. We used mixed-methods repeated-measures regression analyses to evaluate elements of the Ottawa GRS by level of training to predict performance growth throughout a 3-year residency. Results Ottawa GRS scores increased over time, and the domains of leadership, problem solving, and resource utilization, in particular, were predictive of overall performance. There was a significant gain in all Ottawa GRS components between postgraduate years 1 and 2, but no significant difference in GRS performance between years 2 and 3. Conclusions In summary, CRM skills are progressive abilities, and simulation is a useful modality for tracking their development. Modification of this tool may be needed to assess advanced learners’ gains in performance. PMID:25499769

DOE Office of Scientific and Technical Information (OSTI.GOV)

Luna, R. E.

This paper provides a simple model for estimating the release of respirable aerosols resulting from an attack on a spent fuel cask using a high energy density device (HEDD). Two primary experiments have provided data on potential releases from spent fuel casks under HEDD attack. Sandia National Laboratories (SNL) conducted the first in the early 1980's and the second was sponsored by Gessellshaft fur Anlagen- and Reaktorsicherheit (GRS) in Germany and conducted in France in 1994. Both used surrogate spent fuel assemblies in real casks. The SNL experiments used un-pressurized fuel pin assemblies in a single element cask while themore » GRS tests used pressurized fuel pin assemblies in a 9-element cask. Data from the two test programs is reasonably consistent, given the differences in the experiments, but the use of the test data for prediction of releases resulting from HEDD attack requires a method for accounting for the effects of pin pressurization release and the ratio of pin plenum gas release to cask free volume (VR). To account for the effects of VR and to link the two data sources, a simple model has been developed that uses both the SNL data and the GRS data as well as recent test data on aerosols produced in experiments with single pellets subjected to HEDD effects conducted under the aegis of the International Consortium's Working Group on Sabotage of Transport and Storage Casks (WGSTSC). (authors)« less

Velocity and Vorticity Measurements of Jupiter's Great Red Spot Using Automated Cloud Feature Trackers

NASA Astrophysics Data System (ADS)

Choi, D. S.; Gierasch, P.; Banfield, D.; Showman, A.

2005-12-01

During the 28th orbit of Galileo in May 2000, the spacecraft imaged Jupiter's Great Red Spot (GRS) with a remarkable level of detail. Three observations of the vortex were made over a span of about two hours. We have produced mosaics of the GRS at each observation, and have measured the winds of the GRS using an automated algorithm that does not require manual cloud tracking. The advantage of using this method is the production of a high-density, regular grid of wind velocity vectors as compared to a limited number of scattered wind vectors that result from manual cloud tracking [1]. Using the wind velocity measurements, we are able to compute particle trajectories around the GRS as well as relative and absolute vorticities. We have also mapped turbulent eddies inside the chaotic central region of the GRS, similar to those tracked by Sada et al [2]. We calculate how absolute vorticity changes as a function of latitude along a trajectory around the GRS and compare these measurements to similar ones performed by Dowling and Ingersoll using Voyager imaging data [3]. Future projects with the automated cloud feature trackers will analyze Voyager images of the GRS as well as other high-resolution images of Jovian vortices. We also hope to apply this method to other relevant datasets on planetary atmospheres. References: [1] Legarreta, J. and Sanchez-Lavega, A. (2005) Icarus 174: 178--191. [2] Sada, P. et al. (1996) Icarus 119: 311--335. [3] Dowling, T. and Ingersoll, A. (1988) J. Atm. Sci. 45: 1380--1396.

Mediterranean Diet Adherence and Genetic Background Roles within a Web-Based Nutritional Intervention: The Food4Me Study.

PubMed

San-Cristobal, Rodrigo; Navas-Carretero, Santiago; Livingstone, Katherine M; Celis-Morales, Carlos; Macready, Anna L; Fallaize, Rosalind; O'Donovan, Clare B; Lambrinou, Christina P; Moschonis, George; Marsaux, Cyril F M; Manios, Yannis; Jarosz, Miroslaw; Daniel, Hannelore; Gibney, Eileen R; Brennan, Lorraine; Drevon, Christian A; Gundersen, Thomas E; Gibney, Mike; Saris, Wim H M; Lovegrove, Julie A; Grimaldi, Keith; Parnell, Laurence D; Bouwman, Jildau; Van Ommen, Ben; Mathers, John C; Martinez, J Alfredo

2017-10-11

Mediterranean Diet (MedDiet) adherence has been proven to produce numerous health benefits. In addition, nutrigenetic studies have explained some individual variations in the response to specific dietary patterns. The present research aimed to explore associations and potential interactions between MedDiet adherence and genetic background throughout the Food4Me web-based nutritional intervention. Dietary, anthropometrical and biochemical data from volunteers of the Food4Me study were collected at baseline and after 6 months. Several genetic variants related to metabolic risk features were also analysed. A Genetic Risk Score (GRS) was derived from risk alleles and a Mediterranean Diet Score (MDS), based on validated food intake data, was estimated. At baseline, there were no interactions between GRS and MDS categories for metabolic traits. Linear mixed model repeated measures analyses showed a significantly greater decrease in total cholesterol in participants with a low GRS after a 6-month period, compared to those with a high GRS. Meanwhile, a high baseline MDS was associated with greater decreases in Body Mass Index (BMI), waist circumference and glucose. There also was a significant interaction between GRS and the MedDiet after the follow-up period. Among subjects with a high GRS, those with a high MDS evidenced a highly significant reduction in total carotenoids, while among those with a low GRS, there was no difference associated with MDS levels. These results suggest that a higher MedDiet adherence induces beneficial effects on metabolic outcomes, which can be affected by the genetic background in some specific markers.

Genetic Susceptibility, Change in Physical Activity, and Long-term Weight Gain.

PubMed

Wang, Tiange; Huang, Tao; Heianza, Yoriko; Sun, Dianjianyi; Zheng, Yan; Ma, Wenjie; Jensen, Majken K; Kang, Jae H; Wiggs, Janey L; Pasquale, Louis R; Rimm, Eric B; Manson, JoAnn E; Hu, Frank B; Willett, Walter C; Qi, Lu

2017-10-01

Whether change in physical activity over time modifies the genetic susceptibility to long-term weight gain is unknown. We calculated a BMI-genetic risk score (GRS) based on 77 BMI-associated single nucleotide polymorphisms (SNPs) and a body fat percentage (BF%)-GRS based on 12 BF%-associated SNPs in 9,390 women from the Nurses' Health Study (NHS) and 5,291 men from the Health Professionals Follow-Up Study (HPFS). We analyzed the interactions between each GRS and change in physical activity on BMI/body weight change within five 4-year intervals from 1986 to 2006 using multivariable generalized linear models with repeated-measures analyses. Both the BMI-GRS and the BF%-GRS were associated with long-term increases in BMI/weight, and change in physical activity consistently interacted with the BF%-GRS on BMI change in the NHS ( P for interaction = 0.025) and HPFS ( P for interaction = 0.001). In the combined cohorts, 4-year BMI change per 10-risk allele increment was -0.02 kg/m 2 among participants with greatest increase in physical activity and 0.24 kg/m 2 among those with greatest decrease in physical activity ( P for interaction < 0.001), corresponding to 0.01 kg versus 0.63 kg weight changes every 4 years ( P for interaction = 0.001). Similar but marginal interactions were observed for the BMI-GRS ( P for interaction = 0.045). Our data indicate that the genetic susceptibility to weight gain may be diminished by increasing physical activity. © 2017 by the American Diabetes Association.

Columbia/Einstein observations of galactic X-ray sources

NASA Technical Reports Server (NTRS)

Long, K. S.

1979-01-01

The imaging observations of galactic clusters are presented. These fall into three categories: pre-main-sequence stars in the Orion nebulae, isolated-main-and-post main-sequence stars, and supernova remnants SNR. In addition to SNR, approximately 30 sources were detected.

Developing a Risk-scoring Model for Ankylosing Spondylitis Based on a Combination of HLA-B27, Single-nucleotide Polymorphism, and Copy Number Variant Markers.

PubMed

Jung, Seung-Hyun; Cho, Sung-Min; Yim, Seon-Hee; Kim, So-Hee; Park, Hyeon-Chun; Cho, Mi-La; Shim, Seung-Cheol; Kim, Tae-Hwan; Park, Sung-Hwan; Chung, Yeun-Jun

2016-12-01

To develop a genotype-based ankylosing spondylitis (AS) risk prediction model that is more sensitive and specific than HLA-B27 typing. To develop the AS genetic risk scoring (AS-GRS) model, 648 individuals (285 cases and 363 controls) were examined for 5 copy number variants (CNV), 7 single-nucleotide polymorphisms (SNP), and an HLA-B27 marker by TaqMan assays. The AS-GRS model was developed using logistic regression and validated with a larger independent set (576 cases and 680 controls). Through logistic regression, we built the AS-GRS model consisting of 5 genetic components: HLA-B27, 3 CNV (1q32.2, 13q13.1, and 16p13.3), and 1 SNP (rs10865331). All significant associations of genetic factors in the model were replicated in the independent validation set. The discriminative ability of the AS-GRS model measured by the area under the curve was excellent: 0.976 (95% CI 0.96-0.99) in the model construction set and 0.951 (95% CI 0.94-0.96) in the validation set. The AS-GRS model showed higher specificity and accuracy than the HLA-B27-only model when the sensitivity was set to over 94%. When we categorized the individuals into quartiles based on the AS-GRS scores, OR of the 4 groups (low, intermediate-1, intermediate-2, and high risk) showed an increasing trend with the AS-GRS scores (r 2 = 0.950) and the highest risk group showed a 494× higher risk of AS than the lowest risk group (95% CI 237.3-1029.1). Our AS-GRS could be used to identify individuals at high risk for AS before major symptoms appear, which may improve the prognosis for them through early treatment.

Genetic and clinic predictors of new onset diabetes mellitus after transplantation.

PubMed

Saigi-Morgui, Núria; Quteineh, Lina; Bochud, Pierre-Yves; Crettol, Severine; Kutalik, Zoltán; Mueller, Nicolas J; Binet, Isabelle; Van Delden, Christian; Steiger, Jürg; Mohacsi, Paul; Dufour, Jean-Francois; Soccal, Paola M; Pascual, Manuel; Eap, Chin B

2017-12-27

New Onset Diabetes after Transplantation (NODAT) is a frequent complication after solid organ transplantation, with higher incidence during the first year. Several clinical and genetic factors have been described as risk factors of Type 2 Diabetes (T2DM). Additionally, T2DM shares some genetic factors with NODAT. We investigated if three genetic risk scores (w-GRS) and clinical factors were associated with NODAT and how they predicted NODAT development 1 year after transplantation. In both main (n = 725) and replication (n = 156) samples the clinical risk score was significantly associated with NODAT (OR main : 1.60 [1.36-1.90], p = 3.72*10 -8 and OR replication : 2.14 [1.39-3.41], p = 0.0008, respectively). Two w-GRS were significantly associated with NODAT in the main sample (OR w-GRS 2 :1.09 [1.04-1.15], p = 0.001 and OR w-GRS 3 :1.14 [1.01-1.29], p = 0.03) and a similar OR w-GRS 2 was found in the replication sample, although it did not reach significance probably due to a power issue. Despite the low OR of w-GRS on NODAT compared to clinical covariates, when integrating w-GRS 2 and w-GRS 3 in the clinical model, the Area under the Receiver Operating Characteristics curve (AUROC), specificity, sensitivity and accuracy were 0.69, 0.71, 0.58 and 0.68, respectively, with significant Likelihood Ratio test discrimination index (p-value 0.0004), performing better in NODAT discrimination than the clinical model alone. Twenty-five patients needed to be genotyped in order to detect one misclassified case that would have developed NODAT 1 year after transplantation if using only clinical covariates. To our knowledge, this is the first study extensively examining genetic risk scores contributing to NODAT development.

Saturated fat intake modulates the association between an obesity genetic risk score and body mass index in two US populations.

PubMed

Casas-Agustench, Patricia; Arnett, Donna K; Smith, Caren E; Lai, Chao-Qiang; Parnell, Laurence D; Borecki, Ingrid B; Frazier-Wood, Alexis C; Allison, Matthew; Chen, Yii-Der Ida; Taylor, Kent D; Rich, Stephen S; Rotter, Jerome I; Lee, Yu-Chi; Ordovás, José M

2014-12-01

Combining multiple genetic variants related to obesity into a genetic risk score (GRS) might improve identification of individuals at risk of developing obesity. Moreover, characterizing gene-diet interactions is a research challenge to establish dietary recommendations to individuals with higher predisposition to obesity. Our objective was to analyze the association between an obesity GRS and body mass index (BMI) in the Genetics of Lipid Lowering Drugs and Diet Network (GOLDN) population, focusing on gene-diet interactions with total fat and saturated fatty acid (SFA) intake, and to replicate findings in the Multi-Ethnic Study of Atherosclerosis (MESA) population. Cross-sectional analyses included 783 white US participants from GOLDN and 2,035 from MESA. Dietary intakes were estimated with validated food frequency questionnaires. Height and weight were measured. A weighted GRS was calculated on the basis of 63 obesity-associated variants. Multiple linear regression models adjusted by potential confounders were used to examine gene-diet interactions between dietary intake (total fat and SFA) and the obesity GRS in determining BMI. Significant interactions were found between total fat intake and the obesity GRS using these variables as continuous for BMI (P for interaction=0.010, 0.046, and 0.002 in GOLDN, MESA, and meta-analysis, respectively). These association terms were stronger when assessing interactions between SFA intake and GRS for BMI (P for interaction=0.005, 0.018, and <0.001 in GOLDN, MESA, and meta-analysis, respectively). SFA intake interacts with an obesity GRS in modulating BMI in two US populations. Although determining the causal direction requires further investigation, these findings suggest that potential dietary recommendations to reduce BMI effectively in populations with high obesity GRS would be to reduce total fat intake mainly by limiting SFAs. Copyright © 2014 Academy of Nutrition and Dietetics. Published by Elsevier Inc. All rights reserved.

A method for establishing constraints on galactic magnetic field models using ultra high energy cosmic rays and results from the data of the Pierre Auger Observatory

NASA Astrophysics Data System (ADS)

Sutherland, Michael Stephen

2010-12-01

The Galactic magnetic field is poorly understood. Essentially the only reliable measurements of its properties are the local orientation and field strength. Its behavior at galactic scales is unknown. Historically, magnetic field measurements have been performed using radio astronomy techniques which are sensitive to certain regions of the Galaxy and rely upon models of the distribution of gas and dust within the disk. However, the deflection of trajectories of ultra high energy cosmic rays arriving from extragalactic sources depends only on the properties of the magnetic field. In this work, a method is developed for determining acceptable global models of the Galactic magnetic field by backtracking cosmic rays through the field model. This method constrains the parameter space of magnetic field models by comparing a test statistic between backtracked cosmic rays and isotropic expectations for assumed cosmic ray source and composition hypotheses. Constraints on Galactic magnetic field models are established using data from the southern site of the Pierre Auger Observatory under various source distribution and cosmic ray composition hypotheses. Field models possessing structure similar to the stellar spiral arms are found to be inconsistent with hypotheses of an iron cosmic ray composition and sources selected from catalogs tracing the local matter distribution in the universe. These field models are consistent with hypothesis combinations of proton composition and sources tracing the local matter distribution. In particular, strong constraints are found on the parameter space of bisymmetric magnetic field models scanned under hypotheses of proton composition and sources selected from the 2MRS-VS, Swift 39-month, and VCV catalogs. Assuming that the Galactic magnetic field is well-described by a bisymmetric model under these hypotheses, the magnetic field strength near the Sun is less than 3-4 muG and magnetic pitch angle is less than -8°. These results comprise the first measurements of the Galactic magnetic field using ultra-high energy cosmic rays and supplement existing radio astronomical measurements of the Galactic magnetic field.

A comparison of global rating scale and checklist scores in the validation of an evaluation tool to assess performance in the resuscitation of critically ill patients during simulated emergencies (abbreviated as "CRM simulator study IB").

PubMed

Kim, John; Neilipovitz, David; Cardinal, Pierre; Chiu, Michelle

2009-01-01

Crisis resource management (CRM) skills are a set of nonmedical skills required to manage medical emergencies. There is currently no gold standard for evaluation of CRM performance. A prior study examined the use of a global rating scale (GRS) to evaluate CRM performance. This current study compared the use of a GRS and a checklist as formal rating instruments to evaluate CRM performance during simulated emergencies. First-year and third-year residents participated in two simulator scenarios each. Three raters then evaluated resident performance in CRM using edited video recordings using both a GRS and a checklist. The Ottawa GRS provides a seven-point anchored ordinal scale for performance in five categories of CRM, and an overall performance score. The Ottawa CRM checklist provides 12 items in the five categories of CRM, with a maximum cumulative score of 30 points. Construct validity was measured on the basis of content validity, response process, internal structure, and response to other variables. T-test analysis of Ottawa GRS scores was conducted to examine response to the variable of level of training. Intraclass correlation coefficient (ICC) scores were used to measure inter-rater reliability for both scenarios. Thirty-two first-year and 28 third-year residents participated in the study. Third-year residents produced higher mean scores for overall CRM performance than first-year residents (P < 0.05), and in all individual categories within the Ottawa GRS (P < 0.05) and the Ottawa CRM checklist (P < 0.05). This difference was noted for both scenarios and for each individual rater (P < 0.05). No statistically significant difference in resident scores was observed between scenarios for both instruments. ICC scores of 0.59 and 0.61 were obtained for Scenarios 1 and 2 with the Ottawa GRS, whereas ICC scores of 0.63 and 0.55 were obtained with the Ottawa CRM checklist. Users indicated a strong preference for the Ottawa GRS given ease of scoring, presence of an overall score, and the potential for formative evaluation. Construct validity seems to be present when using both the Ottawa GRS and CRM checklist to evaluate CRM performance during simulated emergencies. Data also indicate the presence of moderate inter-rater reliability when using both the Ottawa GRS and CRM checklist.

Interstellar Scattering Towards the Galactic Center as Probed by OH/IR Stars

NASA Technical Reports Server (NTRS)

Vanlangevelde, Huib Jan; Frail, Dale A.; Cordes, James M.; Diamond, Philip J.

1992-01-01

Angular broadening measurements are reported of 20 OH/IR stars near the galactic center. This class of sources is known to have bright, intrinsically compact (less than or equal to 20 mas) maser components within their circumstellar shells. VLBA antennas and the VLA were used to perform a MKII spectral line VLBI experiment. The rapid drop in correlated flux with increasing baseline, especially for sources closest to the galactic center, is attributed to interstellar scattering. Angular diameters were measured for 13 of our sources. Lower limits were obtained for the remaining seven. With the data, together with additional data taken from the literature, the distribution was determined of interstellar scattering toward the galactic center. A region was found of pronounced scattering nearly centered on SgrA*. Two interpretations are considered for the enhanced scattering. One hypothesis is that the scattering is due to a clump of enhanced turbulence, such as those that lie along lines of sight to other known objects, that has no physical relationship to the galactic center. The other model considers the location of the enhanced scattering to arise in the galactic center itself. The physical implications of the models yield information on the nature of interstellar scattering.

Neutrino diagnostics of ultrahigh energy cosmic ray protons

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ahlers, Markus; Sarkar, Subir; Anchordoqui, Luis A.

2009-04-15

The energy at which cosmic rays from extra-galactic sources begin to dominate over those from galactic sources is an important open question in astroparticle physics. A natural candidate is the energy at the 'ankle' in the approximately power-law energy spectrum which is indicative of a crossover from a falling galactic component to a flatter extra-galactic component. The transition can occur without such flattening but this requires some degree of conspiracy of the spectral shapes and normalizations of the two components. Nevertheless, it has been argued that extra-galactic sources of cosmic ray protons that undergo interactions on the CMB can reproducemore » the energy spectrum below the ankle if the crossover energy is as low as the 'second knee' in the spectrum. This low crossover model is constrained by direct measurements by the Pierre Auger Observatory, which indicate a heavier composition at these energies. We demonstrate that upper limits on the cosmic diffuse neutrino flux provide a complementary constraint on the proton fraction in ultra-high energy extra-galactic cosmic rays and forthcoming data from IceCube will provide a definitive test of this model.« less

Galactic water vapor emission: further observations of variability.

PubMed

Knowles, S H; Mayer, C H; Sullivan, W T; Cheung, A C

1969-10-10

Recent observations of the 1.35-centimeter line emission of water vapor from galactic sources show short-term variability in the spectra of several sources. Two additional sources, Cygnus 1 and NGC 6334N, have been observed, and the spectra of W49 and VY Canis Majoris were measured over a wider range of radial velocity.

Gustatory Receptor Expression in the Labella and Tarsi of Aedes aegypti

DTIC Science & Technology

2013-01-01

Gibbs, R., Chen, R., 2011. The Drosophila melanogaster transcriptome by paired-end RNA sequencing . Genome Res. 21, 315e324. Debboun, M., Strickman, D...from genomic sequences and compared to previously identified insect GRs (Kent et al., 2008). In general, GRs of the two main mosquito sub- families...almost always demonstrated conservation in Drosophila melanogaster as well. Twelve out the total 40 AaegGRs with likely orthologs in An. gambiae had

Identifying Gifted Preschoolers in Turkey: The Reliability and Validity of the Turkish-Translated Version of the GRS-Preschool/Kindergarten Form

ERIC Educational Resources Information Center

Karadag, Filiz; Karabey, Burak; Pfeiffer, Steven

2016-01-01

The reliability and validity of the Turkish-translated version of the Gifted Rating Scales (GRS) were tested on 30 preschool teachers who provided ratings for a total of 390 preschoolers aged ranging from 4 years, 0 months to 6 years, 11 months. Results indicated that the reliability and validity of all five of the GRS-P subscales were high.…

A Targeted Search for Point Sources of EeV Photons with the Pierre Auger Observatory

NASA Astrophysics Data System (ADS)

Aab, A.; Abreu, P.; Aglietta, M.; Samarai, I. Al; Albuquerque, I. F. M.; Allekotte, I.; Almela, A.; Alvarez Castillo, J.; Alvarez-Muñiz, J.; Anastasi, G. A.; Anchordoqui, L.; Andrada, B.; Andringa, S.; Aramo, C.; Arqueros, F.; Arsene, N.; Asorey, H.; Assis, P.; Aublin, J.; Avila, G.; Badescu, A. M.; Balaceanu, A.; Barreira Luz, R. J.; Beatty, J. J.; Becker, K. H.; Bellido, J. A.; Berat, C.; Bertaina, M. E.; Bertou, X.; Biermann, P. L.; Billoir, P.; Biteau, J.; Blaess, S. G.; Blanco, A.; Blazek, J.; Bleve, C.; Boháčová, M.; Boncioli, D.; Bonifazi, C.; Borodai, N.; Botti, A. M.; Brack, J.; Brancus, I.; Bretz, T.; Bridgeman, A.; Briechle, F. L.; Buchholz, P.; Bueno, A.; Buitink, S.; Buscemi, M.; Caballero-Mora, K. S.; Caccianiga, L.; Cancio, A.; Canfora, F.; Caramete, L.; Caruso, R.; Castellina, A.; Cataldi, G.; Cazon, L.; Chavez, A. G.; Chinellato, J. A.; Chudoba, J.; Clay, R. W.; Colalillo, R.; Coleman, A.; Collica, L.; Coluccia, M. R.; Conceição, R.; Contreras, F.; Cooper, M. J.; Coutu, S.; Covault, C. E.; Cronin, J.; D'Amico, S.; Daniel, B.; Dasso, S.; Daumiller, K.; Dawson, B. R.; de Almeida, R. M.; de Jong, S. J.; De Mauro, G.; de Mello Neto, J. R. T.; De Mitri, I.; de Oliveira, J.; de Souza, V.; Debatin, J.; Deligny, O.; Di Giulio, C.; Di Matteo, A.; Díaz Castro, M. L.; Diogo, F.; Dobrigkeit, C.; D'Olivo, J. C.; Dorosti, Q.; dos Anjos, R. C.; Dova, M. T.; Dundovic, A.; Ebr, J.; Engel, R.; Erdmann, M.; Erfani, M.; Escobar, C. O.; Espadanal, J.; Etchegoyen, A.; Falcke, H.; Farrar, G.; Fauth, A. C.; Fazzini, N.; Fick, B.; Figueira, J. M.; Filipčič, A.; Fratu, O.; Freire, M. M.; Fujii, T.; Fuster, A.; Gaior, R.; García, B.; Garcia-Pinto, D.; Gaté, F.; Gemmeke, H.; Gherghel-Lascu, A.; Ghia, P. L.; Giaccari, U.; Giammarchi, M.; Giller, M.; Głas, D.; Glaser, C.; Golup, G.; Gómez Berisso, M.; Gómez Vitale, P. F.; González, N.; Gorgi, A.; Gorham, P.; Grillo, A. F.; Grubb, T. D.; Guarino, F.; Guedes, G. P.; Hampel, M. R.; Hansen, P.; Harari, D.; Harrison, T. A.; Harton, J. L.; Haungs, A.; Hebbeker, T.; Heck, D.; Heimann, P.; Herve, A. E.; Hill, G. C.; Hojvat, C.; Holt, E.; Homola, P.; Hörandel, J. R.; Horvath, P.; Hrabovský, M.; Huege, T.; Hulsman, J.; Insolia, A.; Isar, P. G.; Jandt, I.; Jansen, S.; Johnsen, J. A.; Josebachuili, M.; Kääpä, A.; Kambeitz, O.; Kampert, K. H.; Katkov, I.; Keilhauer, B.; Kemp, E.; Kemp, J.; Kieckhafer, R. M.; Klages, H. O.; Kleifges, M.; Kleinfeller, J.; Krause, R.; Krohm, N.; Kuempel, D.; Kukec Mezek, G.; Kunka, N.; Kuotb Awad, A.; LaHurd, D.; Lauscher, M.; Legumina, R.; Leigui de Oliveira, M. A.; Letessier-Selvon, A.; Lhenry-Yvon, I.; Link, K.; Lopes, L.; López, R.; López Casado, A.; Luce, Q.; Lucero, A.; Malacari, M.; Mallamaci, M.; Mandat, D.; Mantsch, P.; Mariazzi, A. G.; Mariş, I. C.; Marsella, G.; Martello, D.; Martinez, H.; Martínez Bravo, O.; Masías Meza, J. J.; Mathes, H. J.; Mathys, S.; Matthews, J.; Matthews, J. A. J.; Matthiae, G.; Mayotte, E.; Mazur, P. O.; Medina, C.; Medina-Tanco, G.; Melo, D.; Menshikov, A.; Micheletti, M. I.; Middendorf, L.; Minaya, I. A.; Miramonti, L.; Mitrica, B.; Mockler, D.; Mollerach, S.; Montanet, F.; Morello, C.; Mostafá, M.; Müller, A. L.; Müller, G.; Muller, M. A.; Müller, S.; Mussa, R.; Naranjo, I.; Nellen, L.; Nguyen, P. H.; Niculescu-Oglinzanu, M.; Niechciol, M.; Niemietz, L.; Niggemann, T.; Nitz, D.; Nosek, D.; Novotny, V.; Nožka, H.; Núñez, L. A.; Ochilo, L.; Oikonomou, F.; Olinto, A.; Palatka, M.; Pallotta, J.; Papenbreer, P.; Parente, G.; Parra, A.; Paul, T.; Pech, M.; Pedreira, F.; Pȩkala, J.; Pelayo, R.; Peña-Rodriguez, J.; Pereira, L. A. S.; Perlín, M.; Perrone, L.; Peters, C.; Petrera, S.; Phuntsok, J.; Piegaia, R.; Pierog, T.; Pieroni, P.; Pimenta, M.; Pirronello, V.; Platino, M.; Plum, M.; Porowski, C.; Prado, R. R.; Privitera, P.; Prouza, M.; Quel, E. J.; Querchfeld, S.; Quinn, S.; Ramos-Pollan, R.; Rautenberg, J.; Ravignani, D.; Revenu, B.; Ridky, J.; Risse, M.; Ristori, P.; Rizi, V.; Rodrigues de Carvalho, W.; Rodriguez Fernandez, G.; Rodriguez Rojo, J.; Rogozin, D.; Roncoroni, M. J.; Roth, M.; Roulet, E.; Rovero, A. C.; Ruehl, P.; Saffi, S. J.; Saftoiu, A.; Salamida, F.; Salazar, H.; Saleh, A.; Salesa Greus, F.; Salina, G.; Sánchez, F.; Sanchez-Lucas, P.; Santos, E. M.; Santos, E.; Sarazin, F.; Sarmento, R.; Sarmiento, C. A.; Sato, R.; Schauer, M.; Scherini, V.; Schieler, H.; Schimp, M.; Schmidt, D.; Scholten, O.; Schovánek, P.; Schröder, F. G.; Schulz, A.; Schulz, J.; Schumacher, J.; Sciutto, S. J.; Segreto, A.; Settimo, M.; Shadkam, A.; Shellard, R. C.; Sigl, G.; Silli, G.; Sima, O.; Śmiałkowski, A.; Šmída, R.; Snow, G. R.; Sommers, P.; Sonntag, S.; Sorokin, J.; Squartini, R.; Stanca, D.; Stanič, S.; Stasielak, J.; Stassi, P.; Strafella, F.; Suarez, F.; Suarez Durán, M.; Sudholz, T.; Suomijärvi, T.; Supanitsky, A. D.; Swain, J.; Szadkowski, Z.; Taboada, A.; Taborda, O. A.; Tapia, A.; Theodoro, V. M.; Timmermans, C.; Todero Peixoto, C. J.; Tomankova, L.; Tomé, B.; Torralba Elipe, G.; Travnicek, P.; Trini, M.; Ulrich, R.; Unger, M.; Urban, M.; Valdés Galicia, J. F.; Valiño, I.; Valore, L.; van Aar, G.; van Bodegom, P.; van den Berg, A. M.; van Vliet, A.; Varela, E.; Vargas Cárdenas, B.; Varner, G.; Vázquez, J. R.; Vázquez, R. A.; Veberič, D.; Vergara Quispe, I. D.; Verzi, V.; Vicha, J.; Villaseñor, L.; Vorobiov, S.; Wahlberg, H.; Wainberg, O.; Walz, D.; Watson, A. A.; Weber, M.; Weindl, A.; Wiencke, L.; Wilczyński, H.; Winchen, T.; Wirtz, M.; Wittkowski, D.; Wundheiler, B.; Yang, L.; Yelos, D.; Yushkov, A.; Zas, E.; Zavrtanik, D.; Zavrtanik, M.; Zepeda, A.; Zimmermann, B.; Ziolkowski, M.; Zong, Z.; Zuccarello, F.

2017-03-01

Simultaneous measurements of air showers with the fluorescence and surface detectors of the Pierre Auger Observatory allow a sensitive search for EeV photon point sources. Several Galactic and extragalactic candidate objects are grouped in classes to reduce the statistical penalty of many trials from that of a blind search and are analyzed for a significant excess above the background expectation. The presented search does not find any evidence for photon emission at candidate sources, and combined p-values for every class are reported. Particle and energy flux upper limits are given for selected candidate sources. These limits significantly constrain predictions of EeV proton emission models from non-transient Galactic and nearby extragalactic sources, as illustrated for the particular case of the Galactic center region.

Venus Measurements by the MESSENGER Gamma-Ray and X-Ray Spectrometers

NASA Astrophysics Data System (ADS)

Rhodes, E. A.; Starr, R. D.; Goldsten, J. O.; Schlemm, C. E.; Boynton, W. V.

2007-12-01

The Gamma-Ray Spectrometer (GRS), which is a part of the Gamma-Ray and Neutron Spectrometer Instrument, and the X-Ray Spectrometer (XRS) on the MESSENGER spacecraft made calibration measurements during the Venus flyby on June 5, 2007. The purpose of these instruments is to determine elemental abundances on the surface of Mercury. The GRS measures gamma-rays emitted from element interactions with cosmic rays impinging on the surface, while the XRS measures X-ray emissions induced on the surface by the incident solar flux. The GRS sensor is a high-resolution high-purity Ge detector cooled by a Stirling cryocooler, surrounded by a borated-plastic anticoincidence shield. The GRS is sensitive to gamma-rays up to ~10 MeV and can identify most major elements, sampling down to depths of about ten centimeters. Only the shield was powered on for this flyby in order to conserve cooler lifetime. Gamma-rays were observed coming from Venus as well as from the spacecraft. Although the Venus gamma-rays originate from its thick atmosphere rather than its surface, the GRS data from this encounter will provide useful calibration data from a source of known composition. In particular, the data will be useful for determining GRS sensitivity and pointing options for the Mercury flybys, the first of which will be in January 2008. The X-ray spectrum of a planetary surface is dominated by a combination of the fluorescence and scattered solar X-rays. The most prominent fluorescent lines are the Kα lines from the major elements Mg, Al, Si, S, Ca, Ti, and Fe (1-10 keV). The sampling depth is less than 100 u m. The XRS is similar in design to experiments flown on Apollo 15 and 16 and the NEAR-Shoemaker mission. Three large-area gas-proportional counters view the planet, and a small Si-PIN detector mounted on the spacecraft sunshade monitors the Sun. The energy resolution of the gas proportional counters (~850 eV at 5.9 keV) is sufficient to resolve the X-ray lines above 2 keV, but Al and Mg filters on two of the three gas counters are required to differentially separate the lower energy X-ray lines from Al, Mg, and Si. A Be-Cu honeycomb collimator provides a 12° field of view, which is smaller than the planet at apoapsis and reduces the X-ray sky background. The Venus atmosphere is almost entirely composed of carbon and oxygen that fluoresce below the energy range of the XRS, but the flyby still provided valuable experience in planning for the upcoming Mercury flybys.

Discovery of a GeV blazar shining through the galactic plane

DOE PAGES

Vandenbroucke, J.; Buehler, R.; Ajello, M.; ...

2010-07-14

The Fermi Large Area Telescope (LAT) discovered a new gamma-ray source near the Galactic plane, Fermi J0109+6134, when it flared brightly in 2010 February. The low Galactic latitude (b = –1more » $$ο\\atop{.}$$2) indicated that the source could be located within the Galaxy, which motivated rapid multi-wavelength follow-up including radio, optical, and X-ray observations. Here, we report the results of analyzing all 19 months of LAT data for the source, and of X-ray observations with both Swift and the Chandra X-ray Observatory. We determined the source redshift, z = 0.783, using a Keck Low-Resolution Imaging Spectrometer observation. Finally, we compiled a broadband spectral energy distribution (SED) from both historical and new observations contemporaneous with the 2010 February flare. The redshift, SED, optical line width, X-ray absorption, and multi-band variability indicate that this new GeV source is a blazar seen through the Galactic plane. Because several of the optical emission lines have equivalent width >5 Å, this blazar belongs in the flat-spectrum radio quasar category.« less

Validity evidence of non-technical skills assessment instruments in simulated anaesthesia crisis management.

PubMed

Jirativanont, T; Raksamani, K; Aroonpruksakul, N; Apidechakul, P; Suraseranivongse, S

2017-07-01

We sought to evaluate the validity of two non-technical skills evaluation instruments, the Anaesthetists' Non-Technical Skills (ANTS) behavioural marker system and the Ottawa Global Rating Scale (GRS), to apply them to anaesthesia training. The content validity, response process, internal structure, relations with other variables and consequences were described for validity evidence. Simulated crisis management sessions were initiated during which two trained raters evaluated the performance of postgraduate first-, second- and third-year (PGY-1, PGY-2 and PGY-3) anaesthesia residents. The study included 70 participants, composed of 24 PGY-1, 24 PGY-2 and 22 PGY-3 residents. Both instruments differentiated the non-technical skills of PGY-1 from PGY-3 residents ( P <0.05). Inter-rater agreement was measured using the intraclass correlation coefficient (ICC). For the ANTS instrument, the intraclass correlation coefficients for task management, team-working, situation awareness and decision-making were 0.79, 0.34, 0.81 and 0.70, respectively. For the Ottawa GRS, the intraclass correlation coefficients for overall performance, leadership, problem-solving, situation awareness, resource utilisation and communication skills were 0.86, 0.83, 0.84, 0.87, 0.80 and 0.86, respectively. The Cronbach's alpha for internal consistency of the ANTS instrument was 0.93, and was 0.96 for the Ottawa GRS. There was a high correlation between the ANTS and Ottawa GRS. The raters reported the ease of use of the Ottawa GRS compared to the ANTS. We found sufficient evidence of validity in the ANTS instrument and the Ottawa GRS for the evaluation of non-technical skills in a simulated anaesthesia setting, but the Ottawa GRS was more practical and had higher reliability.

Genetic Predisposition to Ischemic Stroke

PubMed Central

Kamatani, Yoichiro; Takahashi, Atsushi; Hata, Jun; Furukawa, Ryohei; Shiwa, Yuh; Yamaji, Taiki; Hara, Megumi; Tanno, Kozo; Ohmomo, Hideki; Ono, Kanako; Takashima, Naoyuki; Matsuda, Koichi; Wakai, Kenji; Sawada, Norie; Iwasaki, Motoki; Yamagishi, Kazumasa; Ago, Tetsuro; Ninomiya, Toshiharu; Fukushima, Akimune; Hozawa, Atsushi; Minegishi, Naoko; Satoh, Mamoru; Endo, Ryujin; Sasaki, Makoto; Sakata, Kiyomi; Kobayashi, Seiichiro; Ogasawara, Kuniaki; Nakamura, Motoyuki; Hitomi, Jiro; Kita, Yoshikuni; Tanaka, Keitaro; Iso, Hiroyasu; Kitazono, Takanari; Kubo, Michiaki; Tanaka, Hideo; Tsugane, Shoichiro; Kiyohara, Yutaka; Yamamoto, Masayuki; Sobue, Kenji; Shimizu, Atsushi

2017-01-01

Background and Purpose— The prediction of genetic predispositions to ischemic stroke (IS) may allow the identification of individuals at elevated risk and thereby prevent IS in clinical practice. Previously developed weighted multilocus genetic risk scores showed limited predictive ability for IS. Here, we investigated the predictive ability of a newer method, polygenic risk score (polyGRS), based on the idea that a few strong signals, as well as several weaker signals, can be collectively informative to determine IS risk. Methods— We genotyped 13 214 Japanese individuals with IS and 26 470 controls (derivation samples) and generated both multilocus genetic risk scores and polyGRS, using the same derivation data set. The predictive abilities of each scoring system were then assessed using 2 independent sets of Japanese samples (KyushuU and JPJM data sets). Results— In both validation data sets, polyGRS was shown to be significantly associated with IS, but weighted multilocus genetic risk scores was not. Comparing the highest with the lowest polyGRS quintile, the odds ratios for IS were 1.75 (95% confidence interval, 1.33–2.31) and 1.99 (95% confidence interval, 1.19–3.33) in the KyushuU and JPJM samples, respectively. Using the KyushuU samples, the addition of polyGRS to a nongenetic risk model resulted in a significant improvement of the predictive ability (net reclassification improvement=0.151; P<0.001). Conclusions— The polyGRS was shown to be superior to weighted multilocus genetic risk scores as an IS prediction model. Thus, together with the nongenetic risk factors, polyGRS will provide valuable information for individual risk assessment and management of modifiable risk factors. PMID:28034966

Cross-evaluation of reflectivity from the space-borne precipitation radar and multi-type ground-based weather radar network in China

NASA Astrophysics Data System (ADS)

Zhong, Lingzhi; Yang, Rongfang; Wen, Yixin; Chen, Lin; Gou, Yabin; Li, Ruiyi; Zhou, Qing; Hong, Yang

2017-11-01

China operational weather radar network consists of more than 200 ground-based radars (GR(s)). The lack of unified calibrators often result in poor mosaic products as well as its limitation in radar data assimilation in numerical models. In this study, radar reflectivity and precipitation vertical structures observed from space-borne TRMM (Tropical Rainfall Measurement Mission) PR (precipitation radar) and GRs are volumetrically matched and cross-evaluated. It is found that observation of GRs is basically consistent with that of PR. For their overlapping scanning regions, the GRs are often affected by the beam blockage for complex terrain. The statistics show the better agreement among S band A type (SA) radars, S band B type (SB) radars and PR, as well as poor performance of S band C type (SC) radars. The reflectivity offsets between GRs and PR depend on the reflectivity magnitudes: They are positive for weak precipitation and negative for middle and heavy precipitation, respectively. Although the GRs are quite consistent with PR for large sample, an individual GR has its own fluctuated biases monthly. When the sample number is small, the bias statistics may be determined by a single bad GR in a group. Results from this study shed lights that the space-borne precipitation radars could be used to quantitatively calibrate systematic bias existing in different GRs in order to improve the consistency of ground-based weather radar network across China, and also bears the promise to provide a robust reference even form a space and ground constellation network for the dual-frequency precipitation radars onboard the satellites anticipated in the near future.

The outburst duration and duty cycle of GRS1915+105

NASA Astrophysics Data System (ADS)

Deegan, Patrick; Combet, Céline; Wynn, Graham A.

2009-12-01

The extraordinarily long outburst of GRS1915+105 makes it one of the most remarkable low-mass X-ray binaries (LMXBs). It has been in a state of constant outburst since its discovery in 1992, an eruption which has persisted ~100 times longer than those of more typical LXMBs. The long orbital period of GRS1915+105 implies that it contains large and massive accretion disc which is able to fuel its extreme outburst. In this paper, we address the longevity of the outburst and quiescence phases of GRS1915+105 using smooth particle hydrodynamics (SPH) simulations of its accretion disc through many outburst cycles. Our model is set in the two-α framework and includes the effects of the thermoviscous instability, tidal torques, irradiation by central X-rays and wind mass loss. We explore the model parameter space and examine the impact of the various ingredients. We predict that the outburst of GRS1915+105 should last a minimum of 20yr and possibly up to ~100yr if X-ray irradiation is very significant. The predicted recurrence times are of the order of 104yr, making the X-ray duty cycle a few 0.1 per cent. Such a low duty cycle may mean that GRS1915+105 is not an anomaly among the more standard LMXBs and that many similar, but quiescent, systems could be present in the Galaxy.

Parent Involvement in the Getting Ready for School Intervention Is Associated With Changes in School Readiness Skills.

PubMed

Marti, Maria; Merz, Emily C; Repka, Kelsey R; Landers, Cassie; Noble, Kimberly G; Duch, Helena

2018-01-01

The role of parent involvement in school readiness interventions is not well-understood. The Getting Ready for School (GRS) intervention is a novel program that has both home and school components and aims to improve early literacy, math, and self-regulatory skills in preschool children from socioeconomically disadvantaged families. In this study, we first examined associations between family characteristics and different indices of parent involvement in the GRS intervention. We then examined associations between parent involvement and change in children's school readiness skills over time. Participants were 133 preschool children attending Head Start and their parents who participated in the GRS intervention during the academic year 2014-2015. Parent involvement was operationalized as attendance to GRS events at the school, time spent at home doing GRS activities, and usage of digital program materials, which included a set of videos to support the implementation of parent-child activities at home. Although few family characteristics were significantly associated with parent involvement indices, there was a tendency for some markers of higher socioeconomic status to be linked with greater parent involvement. In addition, greater parent involvement in the GRS intervention was significantly associated with greater gains in children's early literacy, math, and self-regulatory skills. These findings suggest that parent involvement in comprehensive early interventions could be beneficial in terms of improving school readiness for preschoolers from disadvantaged families.

Parent Involvement in the Getting Ready for School Intervention Is Associated With Changes in School Readiness Skills

PubMed Central

Marti, Maria; Merz, Emily C.; Repka, Kelsey R.; Landers, Cassie; Noble, Kimberly G.; Duch, Helena

2018-01-01

The role of parent involvement in school readiness interventions is not well-understood. The Getting Ready for School (GRS) intervention is a novel program that has both home and school components and aims to improve early literacy, math, and self-regulatory skills in preschool children from socioeconomically disadvantaged families. In this study, we first examined associations between family characteristics and different indices of parent involvement in the GRS intervention. We then examined associations between parent involvement and change in children's school readiness skills over time. Participants were 133 preschool children attending Head Start and their parents who participated in the GRS intervention during the academic year 2014–2015. Parent involvement was operationalized as attendance to GRS events at the school, time spent at home doing GRS activities, and usage of digital program materials, which included a set of videos to support the implementation of parent-child activities at home. Although few family characteristics were significantly associated with parent involvement indices, there was a tendency for some markers of higher socioeconomic status to be linked with greater parent involvement. In addition, greater parent involvement in the GRS intervention was significantly associated with greater gains in children's early literacy, math, and self-regulatory skills. These findings suggest that parent involvement in comprehensive early interventions could be beneficial in terms of improving school readiness for preschoolers from disadvantaged families. PMID:29904362

Effect of Vaccinium bracteatum Thunb. leaf pigment on the thermal, pasting, and textural properties and microstructure characterization of rice starch.

PubMed

Xu, Yuan; Fan, Mingcong; Zhou, Sumei; Wang, Li; Qian, Haifeng; Zhang, Hui; Qi, Xiguang

2017-08-01

In this study, the thermal, pasting and gel textural properties of japonica rice starch (JRS) and glutinous rice starch (GRS) fortified with Vaccinium bracteatum Thunb. leaf pigment (VBTLP) were investigated. The results showed that VBTLP facilitated the gelatinization of JRS and GRS with earlier onsets of onset temperature (T o ), peak temperature (T p ), conclusion temperature (T c ), and lower values of gelatinization enthalpy (ΔH g ), and retrogradation enthalpy (ΔH r ), as the VBTLP level increased. For JRS, VBTLP increased the peak viscosity and breakdown, reduced the final viscosity and setback, but for GRS it increased the peak viscosity, final viscosity, breakdown and setback. VBTLP also reduced the hardness and adhesiveness of the JRS gel. The values of lightness (L ∗ ) for JRS and GRS with VBTLP decreased by 47.60 and 49.56%, respectively. Scanning electron microscopy (SEM) revealed that VBTLP caused looser matrices in dried JRS and GRS gels which had lower crystallinities compared with the control. Copyright © 2017 Elsevier Ltd. All rights reserved.

Observations of galactic X-ray sources by OSO-7

NASA Technical Reports Server (NTRS)

Markert, T. H.; Canizares, C. R.; Clark, G. W.; Hearn, D. R.; Li, F. K.; Sprott, G. F.; Winkler, P. F.

1977-01-01

We present the MIT data from the OSO-7 satellite for observations of the galactic plane between 1971 and 1974. A number of sources discovered in the MIT all-sky survey are described in detail: MX 0049 + 59, MX 0836 - 42, MX 1353 - 64, MX 1406 - 61, MX 1418 - 61, MX 1709 - 40, and MX 1608 - 52 (the persistent source suggested to be associated with the X-ray burst source XB 1608 - 52). Upper limits to the X-ray emission from a number of interesting objects are also derived. General results describing all of our observations of galactic sources are presented. Specifically, we display the number-intensity diagrams, luminosity functions, and color-color diagrams for all of the sources we detected. The data are divided between disk and bulge populations, and the characteristics of the two groups are contrasted. Finally, the concept of X-ray source populations and the relationship of globular cluster sources and burst sources to the disk and bulge populations are discussed.

Resolving the structure of the Galactic foreground using Herschel measurements and the Kriging technique

NASA Astrophysics Data System (ADS)

Pinter, S.; Bagoly, Z.; Balázs, L. G.; Horvath, I.; Racz, I. I.; Zahorecz, S.; Tóth, L. V.

2018-05-01

Investigating the distant extragalactic Universe requires a subtraction of the Galactic foreground. One of the major difficulties deriving the fine structure of the galactic foreground is the embedded foreground and background point sources appearing in the given fields. It is especially so in the infrared. We report our study subtracting point sources from Herschel images with Kriging, an interpolation method where the interpolated values are modelled by a Gaussian process governed by prior covariances. Using the Kriging method on Herschel multi-wavelength observations the structure of the Galactic foreground can be studied with much higher resolution than previously, leading to a better foreground subtraction at the end.

The distances of the Galactic Novae

NASA Astrophysics Data System (ADS)

Ozdonmez, Aykut; Guver, Tolga; Cabrera-Lavers, Antonio; Ak, Tansel

2016-07-01

Using location of the RC stars on the CMDs obtained from the UKIDSS, VISTA and 2MASS photometry, we have derived the reddening-distance relations towards each Galactic nova for which at least one independent reddening measurement exists. We were able to determine the distances of 72 Galactic novae and set lower limits on the distances of 45 systems. The reddening curves of the systems are presented. These curves can be also used to estimate reddening or the distance of any source, whose location is close to the position of the nova in our sample. The distance measurement method in our study can be easily applicable to any source, especially for ones that concentrated along the Galactic plane.

Constraints on Galactic Neutrino Emission with Seven Years of IceCube Data

NASA Astrophysics Data System (ADS)

Aartsen, M. G.; Ackermann, M.; Adams, J.; Aguilar, J. A.; Ahlers, M.; Ahrens, M.; Samarai, I. Al; Altmann, D.; Andeen, K.; Anderson, T.; Ansseau, I.; Anton, G.; Argüelles, C.; Auffenberg, J.; Axani, S.; Bagherpour, H.; Bai, X.; Barron, J. P.; Barwick, S. W.; Baum, V.; Bay, R.; Beatty, J. J.; Becker Tjus, J.; Becker, K.-H.; BenZvi, S.; Berley, D.; Bernardini, E.; Besson, D. Z.; Binder, G.; Bindig, D.; Blaufuss, E.; Blot, S.; Bohm, C.; Börner, M.; Bos, F.; Bose, D.; Böser, S.; Botner, O.; Bourbeau, J.; Bradascio, F.; Braun, J.; Brayeur, L.; Brenzke, M.; Bretz, H.-P.; Bron, S.; Burgman, A.; Carver, T.; Casey, J.; Casier, M.; Cheung, E.; Chirkin, D.; Christov, A.; Clark, K.; Classen, L.; Coenders, S.; Collin, G. H.; Conrad, J. M.; Cowen, D. F.; Cross, R.; Day, M.; de André, J. P. A. M.; De Clercq, C.; DeLaunay, J. J.; Dembinski, H.; De Ridder, S.; Desiati, P.; de Vries, K. D.; de Wasseige, G.; de With, M.; DeYoung, T.; Díaz-Vélez, J. C.; di Lorenzo, V.; Dujmovic, H.; Dumm, J. P.; Dunkman, M.; Eberhardt, B.; Ehrhardt, T.; Eichmann, B.; Eller, P.; Evenson, P. A.; Fahey, S.; Fazely, A. R.; Felde, J.; Filimonov, K.; Finley, C.; Flis, S.; Franckowiak, A.; Friedman, E.; Fuchs, T.; Gaisser, T. K.; Gallagher, J.; Gerhardt, L.; Ghorbani, K.; Giang, W.; Glauch, T.; Glüsenkamp, T.; Goldschmidt, A.; Gonzalez, J. G.; Grant, D.; Griffith, Z.; Haack, C.; Hallgren, A.; Halzen, F.; Hanson, K.; Hebecker, D.; Heereman, D.; Helbing, K.; Hellauer, R.; Hickford, S.; Hignight, J.; Hill, G. C.; Hoffman, K. D.; Hoffmann, R.; Hokanson-Fasig, B.; Hoshina, K.; Huang, F.; Huber, M.; Hultqvist, K.; In, S.; Ishihara, A.; Jacobi, E.; Japaridze, G. S.; Jeong, M.; Jero, K.; Jones, B. J. P.; Kalacynski, P.; Kang, W.; Kappes, A.; Karg, T.; Karle, A.; Katz, U.; Kauer, M.; Keivani, A.; Kelley, J. L.; Kheirandish, A.; Kim, J.; Kim, M.; Kintscher, T.; Kiryluk, J.; Kittler, T.; Klein, S. R.; Kohnen, G.; Koirala, R.; Kolanoski, H.; Köpke, L.; Kopper, C.; Kopper, S.; Koschinsky, J. P.; Koskinen, D. J.; Kowalski, M.; Krings, K.; Kroll, M.; Krückl, G.; Kunnen, J.; Kunwar, S.; Kurahashi, N.; Kuwabara, T.; Kyriacou, A.; Labare, M.; Lanfranchi, J. L.; Larson, M. J.; Lauber, F.; Lennarz, D.; Lesiak-Bzdak, M.; Leuermann, M.; Liu, Q. R.; Lu, L.; Lünemann, J.; Luszczak, W.; Madsen, J.; Maggi, G.; Mahn, K. B. M.; Mancina, S.; Maruyama, R.; Mase, K.; Maunu, R.; McNally, F.; Meagher, K.; Medici, M.; Meier, M.; Menne, T.; Merino, G.; Meures, T.; Miarecki, S.; Micallef, J.; Momenté, G.; Montaruli, T.; Moore, R. W.; Moulai, M.; Nahnhauer, R.; Nakarmi, P.; Naumann, U.; Neer, G.; Niederhausen, H.; Nowicki, S. C.; Nygren, D. R.; Obertacke Pollmann, A.; Olivas, A.; O'Murchadha, A.; Palczewski, T.; Pandya, H.; Pankova, D. V.; Peiffer, P.; Pepper, J. A.; Pérez de los Heros, C.; Pieloth, D.; Pinat, E.; Plum, M.; Price, P. B.; Przybylski, G. T.; Raab, C.; Rädel, L.; Rameez, M.; Rawlins, K.; Reimann, R.; Relethford, B.; Relich, M.; Resconi, E.; Rhode, W.; Richman, M.; Robertson, S.; Rongen, M.; Rott, C.; Ruhe, T.; Ryckbosch, D.; Rysewyk, D.; Sälzer, T.; Sanchez Herrera, S. E.; Sandrock, A.; Sandroos, J.; Sarkar, S.; Sarkar, S.; Satalecka, K.; Schlunder, P.; Schmidt, T.; Schneider, A.; Schoenen, S.; Schöneberg, S.; Schumacher, L.; Seckel, D.; Seunarine, S.; Soldin, D.; Song, M.; Spiczak, G. M.; Spiering, C.; Stachurska, J.; Stanev, T.; Stasik, A.; Stettner, J.; Steuer, A.; Stezelberger, T.; Stokstad, R. G.; Stößl, A.; Strotjohann, N. L.; Sullivan, G. W.; Sutherland, M.; Taboada, I.; Tatar, J.; Tenholt, F.; Ter-Antonyan, S.; Terliuk, A.; Tešić, G.; Tilav, S.; Toale, P. A.; Tobin, M. N.; Toscano, S.; Tosi, D.; Tselengidou, M.; Tung, C. F.; Turcati, A.; Turley, C. F.; Ty, B.; Unger, E.; Usner, M.; Vandenbroucke, J.; Van Driessche, W.; van Eijndhoven, N.; Vanheule, S.; van Santen, J.; Vehring, M.; Vogel, E.; Vraeghe, M.; Walck, C.; Wallace, A.; Wallraff, M.; Wandler, F. D.; Wandkowsky, N.; Waza, A.; Weaver, C.; Weiss, M. J.; Wendt, C.; Westerhoff, S.; Whelan, B. J.; Wickmann, S.; Wiebe, K.; Wiebusch, C. H.; Wille, L.; Williams, D. R.; Wills, L.; Wolf, M.; Wood, J.; Wood, T. R.; Woolsey, E.; Woschnagg, K.; Xu, D. L.; Xu, X. W.; Xu, Y.; Yanez, J. P.; Yodh, G.; Yoshida, S.; Yuan, T.; Zoll, M.; IceCube Collaboration

2017-11-01

The origins of high-energy astrophysical neutrinos remain a mystery despite extensive searches for their sources. We present constraints from seven years of IceCube Neutrino Observatory muon data on the neutrino flux coming from the Galactic plane. This flux is expected from cosmic-ray interactions with the interstellar medium or near localized sources. Two methods were developed to test for a spatially extended flux from the entire plane, both of which are maximum likelihood fits but with different signal and background modeling techniques. We consider three templates for Galactic neutrino emission based primarily on gamma-ray observations and models that cover a wide range of possibilities. Based on these templates and in the benchmark case of an unbroken {E}-2.5 power-law energy spectrum, we set 90% confidence level upper limits, constraining the possible Galactic contribution to the diffuse neutrino flux to be relatively small, less than 14% of the flux reported in Aartsen et al. above 1 TeV. A stacking method is also used to test catalogs of known high-energy Galactic gamma-ray sources.

The displacement of the sun from the galactic plane using IRAS and faust source counts

NASA Technical Reports Server (NTRS)

Cohen, Martin

1995-01-01

I determine the displacement of the Sun from the Galactic plane by interpreting IRAS point-source counts at 12 and 25 microns in the Galactic polar caps using the latest version of the SKY model for the point-source sky (Cohen 1994). A value of solar zenith = 15.5 +/- 0.7 pc north of the plane provides the best match to the ensemble of useful IRAS data. Shallow K counts in the north Galactic pole are also best fitted by this offset, while limited FAUST far-ultraviolet counts at 1660 A near the same pole favor a value near 14 pc. Combining the many IRAS determinations with the few FAUST values suggests that a value of solar zenith = 15.0 +/- 0.5 pc (internal error only) would satisfy these high-latitude sets of data in both wavelength regimes, within the context of the SKY model.

A Targeted Search for Point Sources of EeV Photons with the Pierre Auger Observatory

DOE Office of Scientific and Technical Information (OSTI.GOV)

Aab, A.; Abreu, P.; Aglietta, M.

Simultaneous measurements of air showers with the fluorescence and surface detectors of the Pierre Auger Observatory allow a sensitive search for EeV photon point sources. Several Galactic and extragalactic candidate objects are grouped in classes to reduce the statistical penalty of many trials from that of a blind search and are analyzed for a significant excess above the background expectation. The presented search does not find any evidence for photon emission at candidate sources, and combined p-values for every class are reported. Particle and energy flux upper limits are given for selected candidate sources. Lastly, these limits significantly constrain predictionsmore » of EeV proton emission models from non-transient Galactic and nearby extragalactic sources, as illustrated for the particular case of the Galactic center region.« less

A Targeted Search for Point Sources of EeV Photons with the Pierre Auger Observatory

DOE PAGES

Aab, A.; Abreu, P.; Aglietta, M.; ...

2017-03-09

Simultaneous measurements of air showers with the fluorescence and surface detectors of the Pierre Auger Observatory allow a sensitive search for EeV photon point sources. Several Galactic and extragalactic candidate objects are grouped in classes to reduce the statistical penalty of many trials from that of a blind search and are analyzed for a significant excess above the background expectation. The presented search does not find any evidence for photon emission at candidate sources, and combined p-values for every class are reported. Particle and energy flux upper limits are given for selected candidate sources. Lastly, these limits significantly constrain predictionsmore » of EeV proton emission models from non-transient Galactic and nearby extragalactic sources, as illustrated for the particular case of the Galactic center region.« less

A Targeted Search for Point Sources of EeV Photons with the Pierre Auger Observatory

DOE Office of Scientific and Technical Information (OSTI.GOV)

Aab, A.; Abreu, P.; Aglietta, M.

Simultaneous measurements of air showers with the fluorescence and surface detectors of the Pierre Auger Observatory allow a sensitive search for EeV photon point sources. Several Galactic and extragalactic candidate objects are grouped in classes to reduce the statistical penalty of many trials from that of a blind search and are analyzed for a significant excess above the background expectation. The presented search does not find any evidence for photon emission at candidate sources, and combined p -values for every class are reported. Particle and energy flux upper limits are given for selected candidate sources. These limits significantly constrain predictionsmore » of EeV proton emission models from non-transient Galactic and nearby extragalactic sources, as illustrated for the particular case of the Galactic center region.« less

The Hi-GAL compact source catalogue - I. The physical properties of the clumps in the inner Galaxy (-71.0° < ℓ < 67.0°)

NASA Astrophysics Data System (ADS)

Elia, Davide; Molinari, S.; Schisano, E.; Pestalozzi, M.; Pezzuto, S.; Merello, M.; Noriega-Crespo, A.; Moore, T. J. T.; Russeil, D.; Mottram, J. C.; Paladini, R.; Strafella, F.; Benedettini, M.; Bernard, J. P.; Di Giorgio, A.; Eden, D. J.; Fukui, Y.; Plume, R.; Bally, J.; Martin, P. G.; Ragan, S. E.; Jaffa, S. E.; Motte, F.; Olmi, L.; Schneider, N.; Testi, L.; Wyrowski, F.; Zavagno, A.; Calzoletti, L.; Faustini, F.; Natoli, P.; Palmeirim, P.; Piacentini, F.; Piazzo, L.; Pilbratt, G. L.; Polychroni, D.; Baldeschi, A.; Beltrán, M. T.; Billot, N.; Cambrésy, L.; Cesaroni, R.; García-Lario, P.; Hoare, M. G.; Huang, M.; Joncas, G.; Liu, S. J.; Maiolo, B. M. T.; Marsh, K. A.; Maruccia, Y.; Mège, P.; Peretto, N.; Rygl, K. L. J.; Schilke, P.; Thompson, M. A.; Traficante, A.; Umana, G.; Veneziani, M.; Ward-Thompson, D.; Whitworth, A. P.; Arab, H.; Bandieramonte, M.; Becciani, U.; Brescia, M.; Buemi, C.; Bufano, F.; Butora, R.; Cavuoti, S.; Costa, A.; Fiorellino, E.; Hajnal, A.; Hayakawa, T.; Kacsuk, P.; Leto, P.; Li Causi, G.; Marchili, N.; Martinavarro-Armengol, S.; Mercurio, A.; Molinaro, M.; Riccio, G.; Sano, H.; Sciacca, E.; Tachihara, K.; Torii, K.; Trigilio, C.; Vitello, F.; Yamamoto, H.

2017-10-01

Hi-GAL (Herschel InfraRed Galactic Plane Survey) is a large-scale survey of the Galactic plane, performed with Herschel in five infrared continuum bands between 70 and 500 μm. We present a band-merged catalogue of spatially matched sources and their properties derived from fits to the spectral energy distributions (SEDs) and heliocentric distances, based on the photometric catalogues presented in Molinari et al., covering the portion of Galactic plane -71.0° < ℓ < 67.0°. The band-merged catalogue contains 100 922 sources with a regular SED, 24 584 of which show a 70-μm counterpart and are thus considered protostellar, while the remainder are considered starless. Thanks to this huge number of sources, we are able to carry out a preliminary analysis of early stages of star formation, identifying the conditions that characterize different evolutionary phases on a statistically significant basis. We calculate surface densities to investigate the gravitational stability of clumps and their potential to form massive stars. We also explore evolutionary status metrics such as the dust temperature, luminosity and bolometric temperature, finding that these are higher in protostellar sources compared to pre-stellar ones. The surface density of sources follows an increasing trend as they evolve from pre-stellar to protostellar, but then it is found to decrease again in the majority of the most evolved clumps. Finally, we study the physical parameters of sources with respect to Galactic longitude and the association with spiral arms, finding only minor or no differences between the average evolutionary status of sources in the fourth and first Galactic quadrants, or between 'on-arm' and 'interarm' positions.

Genetic risk scores for body fat distribution attenuate weight loss in women during dietary intervention.

PubMed

Svendstrup, M; Allin, K H; Sørensen, T I A; Hansen, T H; Grarup, N; Hansen, T; Vestergaard, H

2018-03-01

The well-established link between body fat distribution and metabolic health has been suggested to act through an impact on the remodeling capacity of the adipose tissue. Remodeling of the adipose tissue has been shown to affect body fat distribution and might affect the ability to lose weight. We aimed to study the effect of weighted genetic risk scores (GRSs) on weight loss based on single-nucleotide polymorphisms (SNPs) associated with waist-hip-ratio adjusted for body mass index (WHRadjBMI). We included 707 participants (533 women and 174 men) from the NUGENOB multi-center 10-week diet intervention study with weekly weight measurements. We created 3 GRSs, one including all reported WHRadjBMI SNPs (GRS total ), one including only SNPs with genome-wide significance in women or with significantly greater effect in women (GRS women ), and one excluding SNPs in the GRS women (GRS men ). The data were analyzed in a mixed linear model framework. The GRS total and GRS women attenuated weight loss in women. The effect was strongest for the GRS women with an effect of 2.21 g per risk allele per day (95% confidence intereval (CI) (0.90;3.52), P=0.0009). Adjustment for WHR, basal metabolic rate or diet compliance did not affect the result. The GRSs had no effect on weight loss in men. The VEGFA rs1358980-T strongly attenuated weight loss in both men and women (β=15.95 g per risk allele per day, (3.16;26.74), P=0.013) and (β=15.95 g per risk allele per day, (2.58;13.53), P=0.004), respectively). Our findings suggest that genetic variants influencing body fat distribution attenuate weight loss in women independently on the effect on WHR. The stronger effect of the GRS women implies heterogenic effects of the WHRadjBMI variants on weight loss. A strong effect of rs1358980-T in the VEGFA locus suggests that angiogenesis plays a role, but this needs confirmation from functional studies.

Genetic risk score and cardiovascular mortality in a southern european population with coronary artery disease.

PubMed

Pereira, Andreia; Mendonca, Maria Isabel; Sousa, Ana Célia; Borges, Sofia; Freitas, Sónia; Henriques, Eva; Rodrigues, Mariana; Freitas, Ana Isabel; Guerra, Graça; Ornelas, Ilídio; Pereira, Décio; Brehm, António; Palma Dos Reis, Roberto

2017-06-01

Several genetic risk scores (GRS) have been associated with cardiovascular disease; their role, however, in survival from proven coronary artery disease (CAD) have yielded conflicting results. The objective of this study was to evaluate long-term cardiovascular mortality according to the genetic risk score in a Southern European population with CAD. A cohort of 1464 CAD patients with angiographic proven CAD were followed up prospectively for up to 58.3 (interquartile range: 25.8-88.1) months. Genotyping of 32 single-nucleotide polymorphisms previously associated with CAD was performed using oligonucleotides probes marked with fluorescence for each allele. GRS was constructed according to the additive model assuming codominance and categorised using the median (=26). Cox Regression analysis was performed to determine independent multivariate predictors of cardiovascular mortality. Kaplan-Meier survival curves compared high vs low GRS using log-rank test. C-index was done for our population, as a measure of discrimination in survival analysis model. During a mean follow-up of 58.3 months, 156 patients (10.7%) died, 107 (7.3%) of CV causes. High GRS (≥26) was associated with reduced cardiovascular survival. Survival analysis with Cox regression model adjusted for 8 variables showed that high GRS, dyslipidemia, diabetes and 3-vessel disease were independent risk factors for cardiovascular mortality (HR=1.53, P=.037; HR=3.64, P=.012; HR=1.75, P=.004; HR=2.97, P<.0001, respectively). At the end of follow-up, the estimated survival probability was 70.8% for high GRS and 80.8% for low GRS (Log-rank test 5.6; P=.018). C-Index of 0.71 was found when GRS was added to a multivariate survival model of diabetes, dyslipidemia, smoking, hypertension and 3 vessel disease, stable angina and dual antiplatelet therapy. Besides the classical risk factors management, this work highlights the relevance of the genetic profile in survival from CAD. It is expected that new therapies will be dirsected to gene targets with proven value in cardiovascular survival. © 2017 John Wiley & Sons Ltd.

Air pollution and diabetes association: Modification by type 2 diabetes genetic risk score.

PubMed

Eze, Ikenna C; Imboden, Medea; Kumar, Ashish; von Eckardstein, Arnold; Stolz, Daiana; Gerbase, Margaret W; Künzli, Nino; Pons, Marco; Kronenberg, Florian; Schindler, Christian; Probst-Hensch, Nicole

2016-09-01

Exposure to ambient air pollution (AP) exposure has been linked to type 2 diabetes (T2D) risk. Evidence on the impact of T2D genetic variants on AP susceptibility is lacking. Compared to single variants, joint genetic variants contribute substantially to disease risk. We investigated the modification of AP and diabetes association by a genetic risk score (GRS) covering 63 T2D genes in 1524 first follow-up participants of the Swiss cohort study on air pollution and lung and heart diseases in adults. Genome-wide data and covariates were available from a nested asthma case-control study design. AP was estimated as 10-year mean residential particulate matter <10μm (PM10). We computed count-GRS and weighted-GRS, and applied PM10 interaction terms in mixed logistic regressions, on odds of diabetes. Analyses were stratified by pathways of diabetes pathology and by asthma status. Diabetes prevalence was 4.6% and mean exposure to PM10 was 22μg/m(3). Odds of diabetes increased by 8% (95% confidence interval: 2, 14%) per T2D risk allele and by 35% (-8, 97%) per 10μg/m(3) exposure to PM10. We observed a positive interaction between PM10 and count-GRS on diabetes [ORinteraction=1.10 (1.01, 1.20)], associations being strongest among participants at the highest quartile of count-GRS [OR: 1.97 (1.00, 3.87)]. Stronger interactions were observed with variants of the GRS involved in insulin resistance [(ORinteraction=1.22 (1.00, 1.50)] than with variants related to beta-cell function. Interactions with count-GRS were stronger among asthma cases. We observed similar results with weighted-GRS. Five single variants near GRB14, UBE2E2, PTPRD, VPS26A and KCNQ1 showed nominally significant interactions with PM10 (P<0.05). Our results suggest that genetic risk for T2D may modify susceptibility to air pollution through alterations in insulin sensitivity. These results need confirmation in diabetes cohort consortia. Copyright © 2016 The Authors. Published by Elsevier Ltd.. All rights reserved.

Quasiperiodic oscillations in bright galactic-bulge X-ray sources

NASA Technical Reports Server (NTRS)

Lamb, F. K.; Shibazaki, N.; Alpar, M. A.; Shaham, J.

1985-01-01

Quasiperiodic oscillations with frequencies in the range 5-50 Hz have recently been discovered in X-rays from two bright galactic-bulge sources and Sco X-1. These sources are weakly magnetic neutron stars accreting from disks which the plasma is clumped. The interaction of the magnetosphere with clumps in the inner disk causes oscillations in the X-ray flux with many of the properties observed.

Using an Alzheimer Disease Polygenic Risk Score to Predict Memory Decline in Black and White Americans Over 14 Years of Follow-up.

PubMed

Marden, Jessica R; Mayeda, Elizabeth R; Walter, Stefan; Vivot, Alexandre; Tchetgen Tchetgen, Eric J; Kawachi, Ichiro; Glymour, M Maria

2016-01-01

Evidence on whether genetic predictors of Alzheimer disease (AD) also predict memory decline is inconsistent, and limited data are available for African ancestry populations. For 8253 non-Hispanic white (NHW) and non-Hispanic black (NHB) Health and Retirement Study participants with memory scores measured 1 to 8 times between 1998 and 2012 (average baseline age=62), we calculated weighted polygenic risk scores [AD Genetic Risk Score (AD-GRS)] using the top 22 AD-associated loci, and an alternative score excluding apolipoprotein E (APOE) (AD-GRSexAPOE). We used generalized linear models with AD-GRS-by-age and AD-GRS-by-age interactions (age centered at 70) to predict memory decline. Average NHB decline was 26% faster than NHW decline (P<0.001). Among NHW, 10% higher AD-GRS predicted faster memory decline (linear β=-0.058 unit decrease over 10 y; 95% confidence interval,-0.074 to -0.043). AD-GRSexAPOE also predicted faster decline for NHW, although less strongly. Among NHB, AD-GRS predicted faster memory decline (linear β=-0.050; 95% confidence interval, -0.106 to 0.006), but AD-GRSexAPOE did not. Our nonsignificant estimate among NHB may reflect insufficient statistical power or a misspecified AD-GRS among NHB as an overwhelming majority of genome-wide association studies are conducted in NHW. A polygenic score based on previously identified AD loci predicts memory loss in US blacks and whites.

Association between genetic risk scoring for schizophrenia and bipolar disorder with regional subcortical volumes.

PubMed

Caseras, X; Tansey, K E; Foley, S; Linden, D

2015-12-08

Previous research has shown coincident abnormal regional brain volume in patients with schizophrenia (SCZ) and bipolar disorder (BD) compared with controls. Whether these abnormalities are genetically driven or explained by secondary effects of the disorder or environmental factors is unknown. We aimed to investigate the association between genetic risk scoring (GRS) for SCZ and BD with volume of brain areas previously shown to be different between these clinical groups and healthy controls. We obtained subcortical brain volume measures and GRS for SCZ and BD from a sample of 274 healthy volunteers (71.4% females, mean age 24.7 (s.d. 6.9)). Volume of the globus pallidus was associated with the shared GRS between SCZ and BD, and also with the independent GRS for each of these disorders. Volume of the amygdala was associated with the non-shared GRS between SCZ and BD, and with the independent GRS for BD. Our results for volume of the globus pallidus support the idea of SCZ and BD sharing a common underlying neurobiological abnormality associated with a common genetic risk for both these disorders. Results for volume of the amygdala, though, would suggest the existence of a distinct mechanism only associated with genetic risk for BD. Finally, the lack of association between genetic risk and volume of most subcortical structures suggests that the volumetric differences reported in patient-control comparisons may not be genetically driven, but a consequence of the disorder or co-occurring environmental factors.

Phylogenetic heritability of geographic range size in haematophagous ectoparasites: time of divergence and variation among continents.

PubMed

Krasnov, Boris R; Shenbrot, Georgy I; van der Mescht, Luther; Warburton, Elizabeth M; Khokhlova, Irina S

2018-04-12

To understand existence, patterns and mechanisms behind phylogenetic heritability in the geographic range size (GRS) of parasites, we measured phylogenetic signal (PS) in the sizes of both regional (within a region) and continental (within a continent) geographic ranges of fleas in five regions. We asked whether (a) GRS is phylogenetically heritable and (b) the manifestation of PS varies between regions. We also asked whether geographic variation in PS reflects the effects of the environment's spatiotemporal stability (e.g. glaciation disrupting geographic ranges) or is associated with time since divergence (accumulation differences among species over time). Support for the former hypothesis would be indicated by stronger PS in southern than in northern regions, whereas support for the latter hypothesis would be shown by stronger PS in regions with a large proportion of species belonging to the derived lineages than in regions with a large proportion of species belonging to the basal lineages. We detected significant PS in both regional and continental GRSs of fleas from Canada and in continental GRS of fleas from Mongolia. No PS was found in the GRS of fleas from Australia and Southern Africa. Venezuelan fleas demonstrated significant PS in regional GRS only. Local Indicators of Phylogenetic Association detected significant local positive autocorrelations of GRS in some clades even in regions in which PS has not been detected across the entire phylogeny. This was mainly characteristic of younger taxa.

Genetic Obesity Risk and Attenuation Effect of Physical Fitness in Mexican-Mestizo Population: a Case-Control Study.

PubMed

Costa-Urrutia, Paula; Abud, Carolina; Franco-Trecu, Valentina; Colistro, Valentina; Rodríguez-Arellano, Martha Eunice; Vázquez-Pérez, Joel; Granados, Julio; Seelaender, Marilia

2017-05-01

We analyzed commonly reported European and Asian obesity-related gene variants in a Mexican-Mestizo population through each single nucleotide polymorphism (SNP) and a genetic risk score (GRS) based on 23 selected SNPs. Study subjects were physically active Mexican-Mestizo adults (n  =  608) with body mass index (BMI) values from 18 to 55 kg/m 2 . For each SNP and for the GRS, logistic models were performed to test for simple SNP associations with BMI, fat mass percentage (FMP), waist circumference (WC), and the interaction with VO 2max and muscular endurance (ME). To further understand the SNP or GRS*physical fitness components, generalized linear models were performed. Obesity risk was significantly associated to 6 SNPs (ADRB2 rs1042713, APOB rs512535, PPARA rs1800206, TNFA rs361525, TRHR rs7832552 and rs16892496) after adjustment by gender, age, ancestry, VO 2max , and ME. ME attenuated the influence of APOB rs512535 and TNFA rs361525 on obesity risk in FMP. WC was significantly associated to GRS. Both ME and VO 2max attenuated GRS effect on WC. We report associations for 6 out of 23 SNPs and for the GRS, which confer obesity risk, a novel finding for Mexican-Mestizo physically active population. Also, the importance of including physical fitness components variables in obesity genetic risk studies is highlighted, with special regard to intervention purposes. © 2017 John Wiley & Sons Ltd/University College London.

Far-Infrared Photometry with an 0.4-Meter Liquid Helium Cooled Balloon-Borne Telescope. Ph.D. Thesis

NASA Technical Reports Server (NTRS)

Jacobson, M. R.

1977-01-01

A 0.4-meter aperture, liquid helium cooled multichannel far-infrared balloon-borne telescope was constructed to survey the galactic plane. Nine new sources, above a 3-sigma confidence level of 1300 Jy, were identified. Although two-thirds of the scanned area was more than 10 degrees from the galactic plane, no sources were detected in that region; all nine fell within 10 degrees and eight of those within 4 degrees of the galactic equator. Correlations with visible, compact H lines associated with radio continuum and with sources displaying spectra steeply rising between 11 and 20 microns were noted, while stellar objects were not detected.

The 1.4-2.7 micron spectrum of the point source at the galactic center

NASA Technical Reports Server (NTRS)

Treffers, R. R.; Fink, U.; Larson, H. P.; Gautier, T. N., III

1976-01-01

The spectrum of the 2-micron point source at the galactic center is presented over the range from 1.4 to 2.7 microns. The two-level-transition CO band heads are seen near 2.3 microns, confirming that the radiation from this source is due to a cool supergiant star. The heliocentric radial velocity is found to be - 173 (+ or -90) km/s and is consistent with the star being in orbit about a dense galactic nucleus. No evidence is found for Brackett-gamma emission, and no interstellar absorption features are seen. Upper limits for the column densities of interstellar H2, CH4, CO, and NH3 are derived.

Understanding EROS2 observations toward the spiral arms within a classical Galactic model framework

NASA Astrophysics Data System (ADS)

Moniez, M.; Sajadian, S.; Karami, M.; Rahvar, S.; Ansari, R.

2017-08-01

Aims: EROS (Expérience de Recherche d'Objets Sombres) has searched for microlensing toward four directions in the Galactic plane away from the Galactic center. The interpretation of the catalog optical depth is complicated by the spread of the source distance distribution. We compare the EROS microlensing observations with Galactic models (including the Besançon model), tuned to fit the EROS source catalogs, and take into account all observational data such as the microlensing optical depth, the Einstein crossing durations, and the color and magnitude distributions of the catalogued stars. Methods: We simulated EROS-like source catalogs using the HIgh-Precision PARallax COllecting Satellite (Hipparcos) database, the Galactic mass distribution, and an interstellar extinction table. Taking into account the EROS star detection efficiency, we were able to produce simulated color-magnitude diagrams that fit the observed diagrams. This allows us to estimate average microlensing optical depths and event durations that are directly comparable with the measured values. Results: Both the Besançon model and our Galactic model allow us to fully understand the EROS color-magnitude data. The average optical depths and mean event durations calculated from these models are in reasonable agreement with the observations. Varying the Galactic structure parameters through simulation, we were also able to deduce contraints on the kinematics of the disk, the disk stellar mass function (at a few kpc distance from the Sun), and the maximum contribution of a thick disk of compact objects in the Galactic plane (Mthick< 5 - 7 × 1010M⊙ at 95%, depending on the model). We also show that the microlensing data toward one of our monitored directions are significantly sensitive to the Galactic bar parameters, although much larger statistics are needed to provide competitive constraints. Conclusions: Our simulation gives a better understanding of the lens and source spatial distributions in the microlensing events. The goodness of a global fit taking into account all the observables (from the color-magnitude diagrams and microlensing observations) shows the validity of the Galactic models. Our tests with the parameters excursions show the unique sensitivity of the microlensing data to the kinematical parameters and stellar initial mass function. http://www.lal.in2p3.fr/recherche/eros

STATISTICS OF GAMMA-RAY POINT SOURCES BELOW THE FERMI DETECTION LIMIT

DOE Office of Scientific and Technical Information (OSTI.GOV)

Malyshev, Dmitry; Hogg, David W., E-mail: dm137@nyu.edu

2011-09-10

An analytic relation between the statistics of photons in pixels and the number counts of multi-photon point sources is used to constrain the distribution of gamma-ray point sources below the Fermi detection limit at energies above 1 GeV and at latitudes below and above 30 deg. The derived source-count distribution is consistent with the distribution found by the Fermi Collaboration based on the first Fermi point-source catalog. In particular, we find that the contribution of resolved and unresolved active galactic nuclei (AGNs) to the total gamma-ray flux is below 20%-25%. In the best-fit model, the AGN-like point-source fraction is 17%more » {+-} 2%. Using the fact that the Galactic emission varies across the sky while the extragalactic diffuse emission is isotropic, we put a lower limit of 51% on Galactic diffuse emission and an upper limit of 32% on the contribution from extragalactic weak sources, such as star-forming galaxies. Possible systematic uncertainties are discussed.« less

Discovery of a Nonblazar Gamma-Ray Transient Source Near the Galactic Plane: GRO J1838-04

NASA Technical Reports Server (NTRS)

Tavani, M.; Oliversen, Ronald (Technical Monitor)

2001-01-01

We report the discovery of a remarkable gamma-ray transient source near the Galactic plane, GRO J1838-04. This source was serendipitously discovered by EGRET in 1995 June with a peak intensity of approx. (4 +/- 1) x 10(exp -6) photons/sq cm s (for photon energies larger than 100 MeV) and a 5.9 sigma significance. At that time, GRO J1838-04 was the second brightest gamma-ray source in the sky. A subsequent EGRET pointing in 1995 late September detected the source at a flux smaller than its peak value by a factor of approx. 7. We determine that no radio-loud spectrally flat blazar is within the error box of GRO J1838-04. We discuss the origin of the gamma-ray transient source and show that interpretations in terms of active galactic nuclei or isolated pulsars are highly problematic. GRO J1838-04 provides strong evidence for the existence of a new class of variable gamma-ray sources.

EX56a study of extended X-ray emission around isolated galaxies EX56b identification and spectra of bright X-ray sources at high galactic latitude

NASA Technical Reports Server (NTRS)

Schwartz, Daniel A.

1987-01-01

The EXOSAT observations confirmed the identification and extended nature of PKS 2345-35. It gave a good 2 to 10 keV X-ray spectrum and a detailed spatial profile indicating asymmetry of the structure. In the high galactic latitidue investigation, the BL Lac object identified with the HEAO-1 source 1430+423 was detected, and the first X-ray spectrum was obtained. Several simulataneous observations of H0323+022 were obtained over a broad range of electromagnetic spectrum. Studies of luminous active galactic nuclei have given significant information on the spectrum of the quasar PKS 0558-504. In a study of Southern sky cataclysmic variables, the EXOSAT was used to determine the X-ray spectrum and search for periodicities in two objects. Studies of complete identifications have revealed that X-ray sources in two high galactic latitude fields are stars, and therefore are to be excluded from the Piccinotti extragalactic sample. Only one Piccinotti source remains to be identified.

Deformation Behaviors of Geosynthetic Reinforced Soil Walls on Shallow Weak Ground

NASA Astrophysics Data System (ADS)

Kim, You-Seong; Won, Myoung-Soo

In this study, the fifteen-month behavior of two geosynthetic reinforced soil walls, which was constructed on the shallow weak ground, was measured and analyzed. The walls were backfilled with clayey soil obtained from the construction site nearby, and the safety factors obtained from general limit equilibrium analysis were less than 1.3 in both wall. To compare with the measured data from the real GRS walls and unreinforced soil mass, a series of finite element method (FEM) analyses on two field GRS walls and unreinforced soil mass were conducted. The FEM analysis results showed that failure plane of unreinforced soil mass was consistent with the Rankine active state, but failure plane did not occur in GRS walls. In addition, maximum horizontal displacements and shear strains in GRS walls were 50% smaller than those found in unreinforced soil mass. Modeling results such as the maximum horizontal displacements, horizontal pressure, and geosynthetic tensile strengths in GRS wall have a god agreement with the measured data. Based on this study, it could be concluded that geosynthetic reinforcement are effective to reduce the displacement of the wall face and/or the deformation of the backfill soil even if the mobilized tensile stress after construction is very small.

Galactic Cosmic Rays: From Earth to Sources

NASA Technical Reports Server (NTRS)

Brandt, Theresa J.

2012-01-01

For nearly 100 years we have known that cosmic rays come from outer space, yet proof of their origin, as well as a comprehensive understanding of their acceleration, remains elusive. Direct detection of high energy (up to 10(exp 15)eV), charged nuclei with experiments such as the balloon-born, antarctic Trans-Iron Galactic Element Recorder (TIGER) have provided insight into these mysteries through measurements of cosmic ray abundances. The abundance of these rare elements with respect to certain intrinsic properties suggests that cosmic rays include a component of massive star ejecta. Supernovae and their remnants (SNe & SNRs), often occurring at the end of a massive star's life or in an environment including massive star material, are one of the most likely candidates for sources accelerating galactic comic ray nuclei up to the requisite high energies. The Fermi Gamma-ray Space Telescope Large Area Detector (Fermi LAT) has improved our understanding of such sources by widening the window of observable energies and thus into potential sources' energetic processes. In combination with multiwavelength observations, we are now better able to constrain particle populations (often hadron-dominated at GeV energies) and environmental conditions, such as the magnetic field strength. The SNR CTB 37A is one such source which could contribute to the observed galactic cosmic rays. By assembling populations of SNRs, we will be able to more definitively define their contribution to the observed galactic cosmic rays, as well as better understand SNRs themselves. Such multimessenger studies will thus illuminate the long-standing cosmic ray mysteries, shedding light on potential sources, acceleration mechanisms, and cosmic ray propagation.

Long term X-ray variability characteristics of the narrow-line Seyfert 1 galaxy RE J1034+396

NASA Astrophysics Data System (ADS)

Chaudhury, K.; Chitnis, V. R.; Rao, A. R.; Singh, K. P.; Bhattacharyya, Sudip; Dewangan, G. C.; Chakraborty, S.; Chandra, S.; Stewart, G. C.; Mukerjee, K.; Dey, R. K.

2018-05-01

We present the results of our study of the long term X-ray variability characteristics of the Narrow Line Seyfert 1 galaxy RE J1034+396. We use data obtained from the AstroSat satellite along with the light curves obtained from XMM-Newton and Swift-XRT. We use the 0.3 - 7.0 keV and 3 - 20 keV data, respectively, from the SXT and the LAXPC of AstroSat. The X-ray spectra in the 0.3 - 20 keV region are well fit with a model consisting of a power-law and a soft excess described by a thermal-Compton emission with a large optical depth, consistent with the earlier reported results. We have examined the X-ray light curves in the soft and hard X-ray bands of SXT and LAXPC, respectively, and find that the variability is slightly larger in the hard band. To investigate the variability characteristics of this source at different time scales, we have used X-ray light curves obtained from XMM-Newton data (200 s to 100 ks range) and Swift-XRT data (1 day to 100 day range) and find that there are evidences to suggest that the variability sharply increases at longer time scales. We argue that the mass of the black hole in RE J1034+396 is likely to be ˜3 × 106 M⊙, based on the similarity of the observed QPO to the high frequency QPO seen in the Galactic black hole binary, GRS 1915+105.

GRS bridge piers and abutments.

DOT National Transportation Integrated Search

2001-01-01

This report presents the following three recent projects on load testing of geosynthetic-reinforced soil (GRS) bridge abutments and piers: a full-scale bridge pier load test conducted by the Turner-Fairbank Highway Research Center, Federal Highway Ad...

Impact of the galactic acceleration on the terrestrial reference frame and the scale factor in VLBI

NASA Astrophysics Data System (ADS)

Krásná, Hana; Titov, Oleg

2017-04-01

The relative motion of the solar system barycentre around the galactic centre can also be described as an acceleration of the solar system directed towards the centre of the Galaxy. So far, this effect has been omitted in the a priori modelling of the Very Long Baseline Interferometry (VLBI) observable. Therefore, it results in a systematic dipole proper motion (Secular Aberration Drift, SAD) of extragalactic radio sources building the celestial reference frame with a theoretical maximum magnitude of 5-7 microarcsec/year. In this work, we present our estimation of the SAD vector obtained within a global adjustment of the VLBI measurements (1979.0 - 2016.5) using the software VieVS. We focus on the influence of the observed radio sources with the maximum SAD effect on the terrestrial reference frame. We show that the scale factor from the VLBI measurements estimated for each source individually discloses a clear systematic aligned with the direction to the Galactic centre-anticentre. Therefore, the radio sources located near Galactic anticentre may cause a strong systematic effect, especially, in early VLBI years. For instance, radio source 0552+398 causes a difference up to 1 mm in the estimated baseline length. Furthermore, we discuss the scale factor estimated for each radio source after removal of the SAD systematic.

VizieR Online Data Catalog: The Red MSX Source Survey: massive protostars (Lumsden+, 2013)

NASA Astrophysics Data System (ADS)

Lumsden, S. L.; Hoare, M. G.; Urquhart, J. S.; Oudmaijer, R. D.; Davies, B.; Mottram, J. C.; Cooper, H. D. B.; Moore, T. J. T.

2013-10-01

The Midcourse Space Experiment (MSX) satellite mission included an astronomy experiment (SPIRIT III) designed to acquire mid-infrared photometry of sources in the Galactic plane (b<5°). MSX had a raw resolution of 18.3", a beam size 50 times smaller than that of IRAS at 12 and 25um. MSX observed six bands between 4 and 21um, of which the four between 8 and 21um are sensitive to astronomical sources. We used v2.3 of the MSX PSC (Egan et al. 2003, Cat. V/114) as our basic input, restricting ourselves to the main Galactic plane catalog, which excludes sources seen in only a single observing pass and those seen in multiple passes but with low significance. We restricted our catalog to 10

Tests of the gravitational redshift effect in space-born and ground-based experiments

NASA Astrophysics Data System (ADS)

Vavilova, I. B.

2018-02-01

This paper provides a brief overview of experiments as concerns with the tests of the gravitational redshift (GRS) effect in ground-based and space-born experiments. In particular, we consider the GRS effects in the gravitational field of the Earth, the major planets of the Solar system, compact stars (white dwarfs and neutron stars) where this effect is confirmed with a higher accuracy. We discuss availabilities to confirm the GRS effect for galaxies and galaxy clusters in visible and X-ray ranges of the electromagnetic spectrum.

Active galactic nuclei

PubMed Central

Fabian, Andrew C.

1999-01-01

Active galactic nuclei are the most powerful, long-lived objects in the Universe. Recent data confirm the theoretical idea that the power source is accretion into a massive black hole. The common occurrence of obscuration and outflows probably means that the contribution of active galactic nuclei to the power density of the Universe has been generally underestimated. PMID:10220363

Comment on “Characterizing the population of pulsars in the Galactic bulge with the Fermi large area telescope” [arXiv:1705.00009v1

DOE PAGES

Bartels, Richard

2018-04-24

Here, themore » $$\\textit{Fermi}$$-LAT Collaboration recently presented a new catalog of gamma-ray sources located within the $$40^{\\circ} \\times 40^{\\circ}$$ region around the Galactic Center~(Ajello et al. 2017) -- the Second Fermi Inner Galaxy (2FIG) catalog. Utilizing this catalog, they analyzed models for the spatial distribution and luminosity function of sources with a pulsar-like gamma-ray spectrum. Ajello et al. 2017 v1 also claimed to detect, in addition to a disk-like population of pulsar-like sources, an approximately 7$$\\sigma$$ preference for an additional centrally concentrated population of pulsar-like sources, which they referred to as a "Galactic Bulge" population. Such a population would be of great interest, as it would support a pulsar interpretation of the gamma-ray excess that has long been observed in this region. In an effort to further explore the implications of this new source catalog, we attempted to reproduce the results presented by the $$\\textit{Fermi}$$-LAT Collaboration, but failed to do so. Mimicking as closely as possible the analysis techniques undertaken in Ajello et al. 2017, we instead find that our likelihood analysis favors a very different spatial distribution and luminosity function for these sources. Most notably, our results do not exhibit a strong preference for a "Galactic Bulge" population of pulsars. Furthermore, we find that masking the regions immediately surrounding each of the 2FIG pulsar candidates does $$\\textit{not}$$ significantly impact the spectrum or intensity of the Galactic Center gamma-ray excess. Although these results refute the claim of strong evidence for a centrally concentrated pulsar population presented in Ajello et al. 2017, they neither rule out nor provide support for the possibility that the Galactic Center excess is generated by a population of low-luminosity and currently largely unobserved pulsars.« less

Comment on “Characterizing the population of pulsars in the Galactic bulge with the Fermi large area telescope” [arXiv:1705.00009v1

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bartels, Richard

Here, themore » $$\\textit{Fermi}$$-LAT Collaboration recently presented a new catalog of gamma-ray sources located within the $$40^{\\circ} \\times 40^{\\circ}$$ region around the Galactic Center~(Ajello et al. 2017) -- the Second Fermi Inner Galaxy (2FIG) catalog. Utilizing this catalog, they analyzed models for the spatial distribution and luminosity function of sources with a pulsar-like gamma-ray spectrum. Ajello et al. 2017 v1 also claimed to detect, in addition to a disk-like population of pulsar-like sources, an approximately 7$$\\sigma$$ preference for an additional centrally concentrated population of pulsar-like sources, which they referred to as a "Galactic Bulge" population. Such a population would be of great interest, as it would support a pulsar interpretation of the gamma-ray excess that has long been observed in this region. In an effort to further explore the implications of this new source catalog, we attempted to reproduce the results presented by the $$\\textit{Fermi}$$-LAT Collaboration, but failed to do so. Mimicking as closely as possible the analysis techniques undertaken in Ajello et al. 2017, we instead find that our likelihood analysis favors a very different spatial distribution and luminosity function for these sources. Most notably, our results do not exhibit a strong preference for a "Galactic Bulge" population of pulsars. Furthermore, we find that masking the regions immediately surrounding each of the 2FIG pulsar candidates does $$\\textit{not}$$ significantly impact the spectrum or intensity of the Galactic Center gamma-ray excess. Although these results refute the claim of strong evidence for a centrally concentrated pulsar population presented in Ajello et al. 2017, they neither rule out nor provide support for the possibility that the Galactic Center excess is generated by a population of low-luminosity and currently largely unobserved pulsars.« less

Comment on "Characterizing the population of pulsars in the Galactic bulge with the Fermi large area telescope" [arXiv:1705.00009v1

NASA Astrophysics Data System (ADS)

Bartels, Richard; Hooper, Dan; Linden, Tim; Mishra-Sharma, Siddharth; Rodd, Nicholas L.; Safdi, Benjamin R.; Slatyer, Tracy R.

2018-06-01

The Fermi-LAT Collaboration recently presented a new catalog of gamma-ray sources located within the 40 ° × 40 ° region around the Galactic Center Ajello et al. (2017) - the Second Fermi Inner Galaxy (2FIG) catalog. Utilizing this catalog, they analyzed models for the spatial distribution and luminosity function of sources with a pulsar-like gamma-ray spectrum. Ajello et al. (2017) v1 also claimed to detect, in addition to a disk-like population of pulsar-like sources, an approximately 7 σ preference for an additional centrally concentrated population of pulsar-like sources, which they referred to as a "Galactic Bulge" population. Such a population would be of great interest, as it would support a pulsar interpretation of the gamma-ray excess that has long been observed in this region. In an effort to further explore the implications of this new source catalog, we attempted to reproduce the results presented by the Fermi-LAT Collaboration, but failed to do so. Mimicking as closely as possible the analysis techniques undertaken in Ajello et al. (2017), we instead find that our likelihood analysis favors a very different spatial distribution and luminosity function for these sources. Most notably, our results do not exhibit a strong preference for a "Galactic Bulge" population of pulsars. Furthermore, we find that masking the regions immediately surrounding each of the 2FIG pulsar candidates does not significantly impact the spectrum or intensity of the Galactic Center gamma-ray excess. Although these results refute the claim of strong evidence for a centrally concentrated pulsar population presented in Ajello et al. (2017), they neither rule out nor provide support for the possibility that the Galactic Center excess is generated by a population of low-luminosity and currently largely unobserved pulsars. In a spirit of maximal openness and transparency, we have made our analysis code available at https://github.com/bsafdi/GCE-2FIG.

The Spatial Variation of Water and Ammonia near Jupiter's Great Red Spot

NASA Technical Reports Server (NTRS)

Bjoraker, G. L.; Orton, G. S.; Collard, A. D.; Stromovsky, L. A.

1999-01-01

The CSHELL spectrometer at NASA's Infrared Telescope Facility was used in August 1996 to observe Jupiter at 5.18 microns. This wavelength sounds the 3-8 bar region in Jupiter's deep troposphere. A 1-arcsec-wide slit was aligned east-west on Jupiter and stepped from north to south across the Great Red Spot (GRS). Within our spectral bandpass are absorption lines of NH3 and a hot band of CH4. Radiative transfer models indicate that the strength of the CH4 feature is anti-correlated with gaseous H2O between 3 and 6 bars. The CH4 feature is predicted to be very strong for H2O abundances less than 10ppm and it should vanish when H2O > 300ppm. The depths of the observed CH4 and NH3 absorption features varied dramatically near the GRS. The center and east side (planetocentric) of the GRS is dry in both volatiles as indicated by strong CH4 absorption and a weak NH3 line. The CH4 line vanishes and the NH3 feature grows stronger on the west side of the GRS. We interpret this as due to a real variation in both volatiles - H2O and NH3 - due to a common dynamical mechanism. Water clouds are expected to be accompanied by saturated gaseous H2O profiles between 3 and 5 bars. The Galileo imaging team (Banfield et al 1998 Icarus 135, p230) deduced the presence of a cloud near the 4-bar level northwest of the GRS. Our data indicate that this same region is volatile rich; thus the combination of the two datasets provides a compelling case for a water cloud at this location. The deep volatile abundance does not correlate with 5-micron continuum opacity near the GRS. This suggests that the spatial variation of the 5-micron flux near the GRS is due primarily to NH3 clouds, rather than H2O clouds.

A genetic risk score is associated with hepatic triglyceride content and non-alcoholic steatohepatitis in Mexicans with morbid obesity.

PubMed

León-Mimila, Paola; Vega-Badillo, Joel; Gutiérrez-Vidal, Roxana; Villamil-Ramírez, Hugo; Villareal-Molina, Teresa; Larrieta-Carrasco, Elena; López-Contreras, Blanca E; Kauffer, Luis R Macías; Maldonado-Pintado, Diana G; Méndez-Sánchez, Nahúm; Tovar, Armando R; Hernández-Pando, Rogelio; Velázquez-Cruz, Rafael; Campos-Pérez, Francisco; Aguilar-Salinas, Carlos A; Canizales-Quinteros, Samuel

2015-04-01

Genome-wide association studies have identified single nucleotide polymorphisms (SNPs) near/in PNPLA3, NCAN, LYPLAL1, PPP1R3B, and GCKR genes associated with non-alcoholic fatty liver disease (NAFLD) mainly in individuals of European ancestry. The aim of the study was to test whether these genetic variants and a genetic risk score (GRS) are associated with elevated liver fat content and non-alcoholic steatohepatitis (NASH) in Mexicans with morbid obesity. 130 morbidly obese Mexican individuals were genotyped for six SNPs in/near PNPLA3, NCAN, LYPLAL1, PPP1R3B, and GCKR genes. Hepatic fat content [triglyceride (HTG) and total cholesterol (HTC)] was quantified directly in liver biopsies and NASH was diagnosed by histology. A GRS was tested for association with liver fat content and NASH using logistic regression models. In addition, 95 ancestry-informative markers were genotyped to estimate population admixture proportions. After adjusting for age, sex and admixture, PNPLA3, LYPLAL1, GCKR and PPP1R3B polymorphisms were associated with higher HTG content (P < 0.05 for PNPLA3, LYPLAL1, GCKR polymorphisms and P = 0.086 for PPP1R3B). The GRS was significantly associated with higher HTG and HTC content (P = 1.0 × 10(-4) and 0.048, respectively), steatosis stage (P = 0.029), and higher ALT levels (P = 0.002). Subjects with GRS ≥ 6 showed a significantly increased risk of NASH (OR = 2.55, P = 0.045) compared to those with GRS ≤ 5. However, the GRS did not predict NASH status, as AUC of ROC curves was 0.56 (P = 0.219). NAFLD associated loci in Europeans and a GRS based on these loci contribute to the accumulation of hepatic lipids and NASH in morbidly obese Mexican individuals. Copyright © 2015 Elsevier Inc. All rights reserved.

Type 2 Diabetes, Diabetes Genetic Score and Risk of Decreased Renal Function and Albuminuria: A Mendelian Randomization Study

PubMed Central

Xu, Min; Bi, Yufang; Huang, Ya; Xie, Lan; Hao, Mingli; Zhao, Zhiyun; Xu, Yu; Lu, Jieli; Chen, Yuhong; Sun, Yimin; Qi, Lu; Wang, Weiqing; Ning, Guang

2016-01-01

Background Type 2 diabetes (T2D) is a risk factor for dysregulation of glomerular filtration rate (GFR) and albuminuria. However, whether the association is causal remains unestablished. Research Design and Methods We performed a Mendelian Randomization (MR) analysis in 11,502 participants aged 40 and above, from a well-defined community in Shanghai during 2011–2013, to explore the causal association between T2D and decreased estimated GFR (eGFR) and increased urinary albumin-to-creatinine ratio (uACR). We genotyped 34 established T2D common variants in East Asians, and created a T2D-genetic risk score (GRS). We defined decreased eGFR as eGFR < 90 ml/min/1.73 m2 and increased uACR as uACR ≥ 30 mg/g. We used the T2D_GRS as the instrumental variable (IV) to quantify the causal effect of T2D on decreased eGFR and increased uACR. Results Each 1-standard deviation (SD, 3.90 points) increment in T2D_GRS was associated with decreased eGFR: odds ratio (OR) = 1.18 (95% confidence interval [CI]: 1.01, 1.30). In the MR analysis, we demonstrated a causal relationship between genetically determined T2D and decreased eGFR (OR = 1.47, 95% CI: 1.15, 1.88, P = 0.0003). When grouping the genetic loci according to their relations with either insulin secretion (IS) or insulin resistance (IR), we found both IS_GRS and IR_GRS were significantly related to decreased eGFR (both P < 0.02). In addition, T2D_GRS and IS_GRS were significantly associated with Log-uACR (both P = 0.04). Conclusion Our results provide novel evidence for a causal association between T2D and decreased eGFR by using MR approach in a Chinese population. PMID:27211558

Type 2 Diabetes, Diabetes Genetic Score and Risk of Decreased Renal Function and Albuminuria: A Mendelian Randomization Study.

PubMed

Xu, Min; Bi, Yufang; Huang, Ya; Xie, Lan; Hao, Mingli; Zhao, Zhiyun; Xu, Yu; Lu, Jieli; Chen, Yuhong; Sun, Yimin; Qi, Lu; Wang, Weiqing; Ning, Guang

2016-04-01

Type 2 diabetes (T2D) is a risk factor for dysregulation of glomerular filtration rate (GFR) and albuminuria. However, whether the association is causal remains unestablished. We performed a Mendelian Randomization (MR) analysis in 11,502 participants aged 40 and above, from a well-defined community in Shanghai during 2011-2013, to explore the causal association between T2D and decreased estimated GFR (eGFR) and increased urinary albumin-to-creatinine ratio (uACR). We genotyped 34 established T2D common variants in East Asians, and created a T2D-genetic risk score (GRS). We defined decreased eGFR as eGFR<90ml/min/1.73m(2) and increased uACR as uACR≥30mg/g. We used the T2D_GRS as the instrumental variable (IV) to quantify the causal effect of T2D on decreased eGFR and increased uACR. Each 1-standard deviation (SD, 3.90 points) increment in T2D_GRS was associated with decreased eGFR: odds ratio (OR)=1.18 (95% confidence interval [CI]: 1.01, 1.30). In the MR analysis, we demonstrated a causal relationship between genetically determined T2D and decreased eGFR (OR=1.47, 95% CI: 1.15, 1.88, P=0.0003). When grouping the genetic loci according to their relations with either insulin secretion (IS) or insulin resistance (IR), we found both IS_GRS and IR_GRS were significantly related to decreased eGFR (both P<0.02). In addition, T2D_GRS and IS_GRS were significantly associated with Log-uACR (both P=0.04). Our results provide novel evidence for a causal association between T2D and decreased eGFR by using MR approach in a Chinese population. Copyright © 2016. Published by Elsevier B.V.

Associations of Genetic Risk Score with Obesity and Related Traits and the Modifying Effect of Physical Activity in a Chinese Han Population

PubMed Central

Zhu, Jingwen; Loos, Ruth J. F.; Lu, Ling; Zong, Geng; Gan, Wei; Ye, Xingwang; Sun, Liang; Li, Huaixing; Lin, Xu

2014-01-01

Background/Objectives Recent large-scale genome-wide association studies have identified multiple loci robustly associated with BMI, predominantly in European ancestry (EA) populations. However, associations of these loci with obesity and related traits have not been well described in Chinese Hans. This study aimed to investigate whether BMI-associated loci are, individually and collectively, associated with adiposity-related traits and obesity in Chinese Hans and whether these associations are modified by physical activity (PA). Subjects/Methods We genotyped 28 BMI-associated single nucleotide polymorphisms (SNPs) in a population-based cohort including 2,894 unrelated Han Chinese. Genetic risk score (GRS), EA and East Asian ancestry (EAA) GRSs were calculated by adding BMI-increasing alleles based on all, EA and EAA identified SNPs, respectively. Interactions of GRS and PA were examined by including the interaction-term in the regression model. Results Individually, 26 of 28 SNPs showed directionally consistent effects on BMI, and associations of four loci (TMEM18, PCSK1, BDNF and MAP2K5) reached nominal significance (P<0.05). The GRS was associated with increased BMI, trunk fat and body fat percentages; and increased risk of obesity and overweight (all P<0.05). Effect sizes (0.11 vs. 0.17 kg/m2) and explained variance (0.90% vs. 1.45%) of GRS for BMI tended to be lower in Chinese Hans than in Europeans. The EA GRS and EAA GRS were associated with 0.11 and 0.13 kg/m2 higher BMI, respectively. In addition, we found that PA attenuated the effect of the GRS on BMI (P interaction = 0.022). Conclusions Our observations suggest that the combined effect of obesity-susceptibility loci on BMI tended to be lower in Han Chinese than in EA. The overall, EA and EAA GRSs exert similar effects on adiposity traits. Genetic predisposition to increased BMI is attenuated by PA in this population of Han Chinese. PMID:24626232

Additive influence of genetic predisposition and conventional risk factors in the incidence of coronary heart disease: a population-based study in Greece

PubMed Central

Yiannakouris, Nikos; Katsoulis, Michail; Trichopoulou, Antonia; Ordovas, Jose M; Trichopoulos, Dimitrios

2014-01-01

Objectives An additive genetic risk score (GRS) for coronary heart disease (CHD) has previously been associated with incident CHD in the population-based Greek European Prospective Investigation into Cancer and nutrition (EPIC) cohort. In this study, we explore GRS-‘environment’ joint actions on CHD for several conventional cardiovascular risk factors (ConvRFs), including smoking, hypertension, type-2 diabetes mellitus (T2DM), body mass index (BMI), physical activity and adherence to the Mediterranean diet. Design A case–control study. Setting The general Greek population of the EPIC study. Participants and outcome measures 477 patients with medically confirmed incident CHD and 1271 controls participated in this study. We estimated the ORs for CHD by dividing participants at higher or lower GRS and, alternatively, at higher or lower ConvRF, and calculated the relative excess risk due to interaction (RERI) as a measure of deviation from additivity. Results The joint presence of higher GRS and higher risk ConvRF was in all instances associated with an increased risk of CHD, compared with the joint presence of lower GRS and lower risk ConvRF. The OR (95% CI) was 1.7 (1.2 to 2.4) for smoking, 2.7 (1.9 to 3.8) for hypertension, 4.1 (2.8 to 6.1) for T2DM, 1.9 (1.4 to 2.5) for lower physical activity, 2.0 (1.3 to 3.2) for high BMI and 1.5 (1.1 to 2.1) for poor adherence to the Mediterranean diet. In all instances, RERI values were fairly small and not statistically significant, suggesting that the GRS and the ConvRFs do not have effects beyond additivity. Conclusions Genetic predisposition to CHD, operationalised through a multilocus GRS, and ConvRFs have essentially additive effects on CHD risk. PMID:24500614

Genetic risk analysis of coronary artery disease in Pakistani subjects using a genetic risk score of 21 variants.

PubMed

Shahid, Saleem Ullah; Shabana; Cooper, Jackie A; Beaney, Katherine E; Li, Kawah; Rehman, Abdul; Humphries, Steve E

2017-03-01

Conventional coronary artery disease (CAD) risk factors like age, gender, blood lipids, hypertension and smoking have been the basis of CAD risk prediction algorithms, but provide only modest discrimination. Genetic risk score (GRS) may provide improved discrimination over and above conventional risk factors. Here we analyzed the genetic risk of CAD in subjects from Pakistan, using a GRS of 21 variants in 18 genes and examined whether the GRS is associated with blood lipid levels. 625 (405 cases and 220 controls) subjects were genotyped for variants, NOS3 rs1799983, SMAD3 rs17228212, APOB rs1042031, LPA rs3798220, LPA rs10455872, SORT1 rs646776, APOE rs429358, GLUL rs10911021, FTO rs9939609, MIA3 rs17465637, CDKN2Ars10757274, DAB2IP rs7025486, CXCL12 rs1746048, ACE rs4341, APOA5 rs662799, CETP rs708272, MRAS rs9818870, LPL rs328, LPL rs1801177, PCSK9 rs11591147 and APOE rs7412 by TaqMan and KASPar allele discrimination techniques. Individually, the single SNPs were not associated with CAD except APOB rs1042031 and FTO rs993969 (p = 0.01 and 0.009 respectively). However, the combined GRS of 21 SNPs was significantly higher in cases than controls (19.37 ± 2.56 vs. 18.47 ± 2.45, p = 2.9 × 10 -5 ), and compared to the bottom quintile, CAD risk in the top quintile of the GRS was 2.96 (95% CI 1.71-5.13). Atherogenic blood lipids showed significant positive association with GRS. The GRS was quantitatively associated with CAD risk and showed association with blood lipid levels, suggesting that the mechanism of these variants is likely to be, in part at least, through creating an atherogenic lipid profile in subjects carrying high numbers of risk alleles. Copyright © 2017 Elsevier B.V. All rights reserved.

Genetic markers enhance coronary risk prediction in men: the MORGAM prospective cohorts.

PubMed

Hughes, Maria F; Saarela, Olli; Stritzke, Jan; Kee, Frank; Silander, Kaisa; Klopp, Norman; Kontto, Jukka; Karvanen, Juha; Willenborg, Christina; Salomaa, Veikko; Virtamo, Jarmo; Amouyel, Phillippe; Arveiler, Dominique; Ferrières, Jean; Wiklund, Per-Gunner; Baumert, Jens; Thorand, Barbara; Diemert, Patrick; Trégouët, David-Alexandre; Hengstenberg, Christian; Peters, Annette; Evans, Alun; Koenig, Wolfgang; Erdmann, Jeanette; Samani, Nilesh J; Kuulasmaa, Kari; Schunkert, Heribert

2012-01-01

More accurate coronary heart disease (CHD) prediction, specifically in middle-aged men, is needed to reduce the burden of disease more effectively. We hypothesised that a multilocus genetic risk score could refine CHD prediction beyond classic risk scores and obtain more precise risk estimates using a prospective cohort design. Using data from nine prospective European cohorts, including 26,221 men, we selected in a case-cohort setting 4,818 healthy men at baseline, and used Cox proportional hazards models to examine associations between CHD and risk scores based on genetic variants representing 13 genomic regions. Over follow-up (range: 5-18 years), 1,736 incident CHD events occurred. Genetic risk scores were validated in men with at least 10 years of follow-up (632 cases, 1361 non-cases). Genetic risk score 1 (GRS1) combined 11 SNPs and two haplotypes, with effect estimates from previous genome-wide association studies. GRS2 combined 11 SNPs plus 4 SNPs from the haplotypes with coefficients estimated from these prospective cohorts using 10-fold cross-validation. Scores were added to a model adjusted for classic risk factors comprising the Framingham risk score and 10-year risks were derived. Both scores improved net reclassification (NRI) over the Framingham score (7.5%, p = 0.017 for GRS1, 6.5%, p = 0.044 for GRS2) but GRS2 also improved discrimination (c-index improvement 1.11%, p = 0.048). Subgroup analysis on men aged 50-59 (436 cases, 603 non-cases) improved net reclassification for GRS1 (13.8%) and GRS2 (12.5%). Net reclassification improvement remained significant for both scores when family history of CHD was added to the baseline model for this male subgroup improving prediction of early onset CHD events. Genetic risk scores add precision to risk estimates for CHD and improve prediction beyond classic risk factors, particularly for middle aged men.

Composite Behavior of Geosynthetic Reinforced Soil Mass

DOT National Transportation Integrated Search

2013-07-01

This study investigated the composite behavior of a geosynthetic reinforced soil (GRS) mass. Many studies have been conducted on the behavior of GRS structures; however, the interactive behavior between the soil and geosynthetic reinforcement in a GR...

How deep is Jupiter's Great Red Spot?

NASA Astrophysics Data System (ADS)

Li, C.; Oyafuso, F. A.; Brown, S. T.; Atreya, S. K.; Orton, G.; Ingersoll, A. P.; Janssen, M. A.

2017-12-01

On its seventh flyby, the Juno spacecraft flew over Jupiter's Great Red Spot (GRS) on its seventh flyby. Its Microwave Radiometer (MWR) measured the thermal emission from Jupiter's atmosphere at six wavelengths. The longest wavelength channel penetrates down to a few hundred bars. This unique observation unveils the internal structure of the GRS for the first time in the history. All six channels have observed brightness temperature anomalies with respect to the background atmosphere. The two longest-wavelength channels, which see the deepest, show warm anomalies and the other four channels show cold anomalies. The structure and magnitude of brightness temperature anomalies agree with the hypothesis that the ammonia gas is well-mixed within the GRS, probably due to rapid overturning. Based on this model, the depth of the GRS is estimated. Further evidence including the gravity signal, the abundance of PH3 and para-hydrogen will also be discussed.

X-ray illumination of globular cluster puzzles. [globular cluster X ray sources as clues to Milky Way Galaxy age and evolution

NASA Technical Reports Server (NTRS)

Lightman, A. P.; Grindlay, J. E.

1982-01-01

Globular clusters are thought to be among the oldest objects in the Galaxy, and provide, in this connection, important clues for determining the age and process of formation of the Galaxy. The present investigation is concerned with puzzles relating to the X-ray emission of globular clusters, taking into account questions regarding the location of X-ray emitting clusters (XEGC) unusually near the galactic plane and/or galactic center. An adopted model is discussed for the nature, formation, and lifetime of X-ray sources in globular clusters. An analysis of the available data is conducted in connection with a search for correlations between binary formation time scales, central relaxation times, galactic locations, and X-ray emission. The positive correlation found between distance from galactic center and two-body binary formation time for globular clusters, explanations for this correlation, and the hypothesis that X-ray sources in globular clusters require binary star systems provide a possible explanation of the considered puzzles.

The near-infrared counterpart of a variable galactic plane radio source

NASA Technical Reports Server (NTRS)

Margon, Bruce; Phillips, Andrew C.; Ciardullo, Robin; Jacoby, George H.

1992-01-01

A near-infrared counterpart to the highly variable, unresolved galactic plane radio source GT 0116 + 622 is identified. This source is of particular interest, as it has been previously suggested to be the counterpart of the gamma-ray source Cas gamma-l. The present NIR and red images detect a faint, spatially extended (3 arcsec FWHM), very red object coincident with the radio position. There is complex spatial structure which may be due in part to an unrelated superposed foreground object. Observations on multiple nights show no evidence for flux variability, despite the high amplitude variability on a time-scale of days reported for the radio source. The data are consistent with an interpretation of GT 0116 + 622 as an unusually variable, obscured active galaxy at a distance of several hundred megaparsecs, although more exotic, and in particular galactic, interpretations cannot yet be ruled out. If the object is extragalactic, the previously suggested identification with the gamma-ray source would seem unlikely.

The Advanced Gamma-ray Imaging System (AGIS): Galactic Astrophysics

NASA Astrophysics Data System (ADS)

Digel, Seth William; Funk, S.; Kaaret, P. E.; Tajima, H.; AGIS Collaboration

2010-03-01

The Advanced Gamma-ray Imaging System (AGIS), a concept for a next-generation atmospheric Cherenkov telescope array, would provide unprecedented sensitivity and resolution in the energy range >50 GeV, allowing great advances in the understanding of the populations and physics of sources of high-energy gamma rays in the Milky Way. Extrapolation based on the known source classes and the performance parameters for AGIS indicates that a survey of the Galactic plane with AGIS will reveal hundreds of TeV sources in exquisite detail, for population studies of a variety of source classes, and detailed studies of individual sources. AGIS will be able to study propagation effects on the cosmic rays produced by Galactic sources by detecting the diffuse glow from their interactions in dense interstellar gas. AGIS will complement and extend results now being obtained in the GeV range with the Fermi mission, by providing superior angular resolution and sensitivity to variability on short time scales, and of course by probing energies that Fermi cannot reach.

A REVIEW OF GRAPHICAL REPRESENTATIONS USED IN THE DIETARY GUIDELINES OF SELECTED COUNTRIES IN THE AMERICAS, EUROPE AND ASIA.

PubMed

Altamirano Martínez, Martha Betzaida; Cordero Muñoz, Aida Yanet; Macedo Ojeda, Gabriela; Márquez Sandoval, Yolanda Fabiola; Vizmanos, Barbara

2015-09-01

Food-Based Dietary Guidelines (FBDGs) are an initiative by the United Nations Food and Agriculture Organization (FAO) and the World Health Organization (WHO) designed to help countries establish their own nutrition education principles. Such principles should be expressed through clear and specific messages that provide guidance and promote good health among populations. Many of these guidelines contain graphical representations (GRs) as visual aids for dietary guidance. to analyze the characteristics of GRs used in various countries on four continents to identify international trends in these graphical messages and assess their usefulness as educational tools for their target populations. a review of GRs used in the FBDGs of countries in the Americas, Europe and Asia for which data were available in Spanish or English. the models most used are the food circle and pyramid. The GRs (n = 37) depict the following recommendations: food groups (37), physical activity (21), water intake (17), low salt intake (7), family meals (1) and relaxation (1). In addition, 10 quantitative recommendations were detected. The GRs of Greece and the United States do not show images of food. The aspects considered in the GRs vary by the regions, cultures and epidemiological characteristics of each country. A tendency to use the food circle and to include lifestyle recommendations in illustrations was observed in the United States, Spain and Mexico. Quantitative recommendations may help to clarify information provided during the educational process. Copyright AULA MEDICA EDICIONES 2014. Published by AULA MEDICA. All rights reserved.

Precise orbit determination using the batch filter based on particle filtering with genetic resampling approach

NASA Astrophysics Data System (ADS)

Kim, Young-Rok; Park, Eunseo; Choi, Eun-Jung; Park, Sang-Young; Park, Chandeok; Lim, Hyung-Chul

2014-09-01

In this study, genetic resampling (GRS) approach is utilized for precise orbit determination (POD) using the batch filter based on particle filtering (PF). Two genetic operations, which are arithmetic crossover and residual mutation, are used for GRS of the batch filter based on PF (PF batch filter). For POD, Laser-ranging Precise Orbit Determination System (LPODS) and satellite laser ranging (SLR) observations of the CHAMP satellite are used. Monte Carlo trials for POD are performed by one hundred times. The characteristics of the POD results by PF batch filter with GRS are compared with those of a PF batch filter with minimum residual resampling (MRRS). The post-fit residual, 3D error by external orbit comparison, and POD repeatability are analyzed for orbit quality assessments. The POD results are externally checked by NASA JPL’s orbits using totally different software, measurements, and techniques. For post-fit residuals and 3D errors, both MRRS and GRS give accurate estimation results whose mean root mean square (RMS) values are at a level of 5 cm and 10-13 cm, respectively. The mean radial orbit errors of both methods are at a level of 5 cm. For POD repeatability represented as the standard deviations of post-fit residuals and 3D errors by repetitive PODs, however, GRS yields 25% and 13% more robust estimation results than MRRS for post-fit residual and 3D error, respectively. This study shows that PF batch filter with GRS approach using genetic operations is superior to PF batch filter with MRRS in terms of robustness in POD with SLR observations.

Genetic Variations of Circulating Adiponectin Levels Modulate Changes in Appetite in Response to Weight-Loss Diets.

PubMed

Ma, Wenjie; Huang, Tao; Heianza, Yoriko; Wang, Tiange; Sun, Dianjianyi; Tong, Jenny; Williamson, Donald A; Bray, George A; Sacks, Frank M; Qi, Lu

2017-01-01

Adiponectin plays key roles in regulating appetite and food intake. To investigate interactions between the genetic risk score (GRS) for adiponectin levels and weight-loss diets varying in macronutrient intake on long-term changes in appetite and adiponectin levels. A GRS was calculated based on 5 adiponectin-associated variants in 692 overweight adults from the 2-year Preventing Overweight Using Novel Dietary Strategies trial. Repeated measurements of plasma adiponectin levels and appetite-related traits, including cravings, fullness, prospective consumption, and hunger. Dietary fat showed nominally significant interactions with the adiponectin GRS on changes in appetite score and prospective consumption from baseline to 6 months (P for interaction = 0.014 and 0.017, respectively) after adjusting for age, sex, ethnicity, baseline body mass index, and baseline respective outcome values. The GRS for lower adiponectin levels was associated with a greater decrease in appetite (P < 0.001) and prospective consumption (P = 0.008) among participants consuming a high-fat diet, whereas no significant associations were observed in the low-fat group. Additionally, a significant interaction was observed between the GRS and dietary fat on 6-month changes in adiponectin levels (P for interaction = 0.021). The lower GRS was associated with a greater increase in adiponectin in the low-fat group (P = 0.02), but it was not associated with adiponectin changes in the high-fat group (P = 0.31). Our findings suggest that individuals with varying genetic architecture of circulating adiponectin may respond divergently in appetite and adiponectin levels to weight-loss diets varying in fat intake. Copyright © 2017 by the Endocrine Society

Predicting stroke through genetic risk functions: The CHARGE risk score project

PubMed Central

Ibrahim-Verbaas, Carla A; Fornage, Myriam; Bis, Joshua C; Choi, Seung Hoan; Psaty, Bruce M; Meigs, James B; Rao, Madhu; Nalls, Mike; Fontes, Joao D; O’Donnell, Christopher J.; Kathiresan, Sekar; Ehret, Georg B.; Fox, Caroline S; Malik, Rainer; Dichgans, Martin; Schmidt, Helena; Lahti, Jari; Heckbert, Susan R; Lumley, Thomas; Rice, Kenneth; Rotter, Jerome I; Taylor, Kent D; Folsom, Aaron R; Boerwinkle, Eric; Rosamond, Wayne D; Shahar, Eyal; Gottesman, Rebecca F.; Koudstaal, Peter J; Amin, Najaf; Wieberdink, Renske G.; Dehghan, Abbas; Hofman, Albert; Uitterlinden, André G; DeStefano, Anita L.; Debette, Stephanie; Xue, Luting; Beiser, Alexa; Wolf, Philip A.; DeCarli, Charles; Ikram, M. Arfan; Seshadri, Sudha; Mosley, Thomas H; Longstreth, WT; van Duijn, Cornelia M; Launer, Lenore J

2014-01-01

Background and Purpose Beyond the Framingham Stroke Risk Score (FSRS), prediction of future stroke may improve with a genetic risk score (GRS) based on Single nucleotide polymorphisms (SNPs) associated with stroke and its risk factors. Methods The study includes four population-based cohorts with 2,047 first incident strokes from 22,720 initially stroke-free European origin participants aged 55 years and older, who were followed for up to 20 years. GRS were constructed with 324 SNPs implicated in stroke and 9 risk factors. The association of the GRS to first incident stroke was tested using Cox regression; the GRS predictive properties were assessed with Area under the curve (AUC) statistics comparing the GRS to age sex, and FSRS models, and with reclassification statistics. These analyses were performed per cohort and in a meta-analysis of pooled data. Replication was sought in a case-control study of ischemic stroke (IS). Results In the meta-analysis, adding the GRS to the FSRS, age and sex model resulted in a significant improvement in discrimination (All stroke: Δjoint AUC =0.016, p-value=2.3*10-6; IS: Δ joint AUC =0.021, p-value=3.7*10−7), although the overall AUC remained low. In all studies there was a highly significantly improved net reclassification index (p-values <10−4). Conclusions The SNPs associated with stroke and its risk factors result only in a small improvement in prediction of future stroke compared to the classical epidemiological risk factors for stroke. PMID:24436238

Diffuse Gamma Rays Galactic and Extragalactic Diffuse Emission

NASA Technical Reports Server (NTRS)

Moskalenko, Igor V.; Strong, Andrew W.; Reimer, Olaf

2004-01-01

Diffuse gamma rays consist of several components: truly diffuse emission from the interstellar medium, the extragalactic background, whose origin is not firmly established yet, and the contribution from unresolved and faint Galactic point sources. One approach to unravel these components is to study the diffuse emission from the interstellar medium, which traces the interactions of high energy particles with interstellar gas and radiation fields. Because of its origin such emission is potentially able to reveal much about the sources and propagation of cosmic rays. The extragalactic background, if reliably determined, can be used in cosmological and blazar studies. Studying the derived average spectrum of faint Galactic sources may be able to give a clue to the nature of the emitting objects.

Spectral Modeling of the EGRET 3EG Gamma Ray Sources Near the Galactic Plane

NASA Technical Reports Server (NTRS)

Bertsch, D. L.; Hartman, R. C.; Hunter, S. D.; Thompson, D. J.; Lin, Y. C.; Kniffen, D. A.; Kanbach, G.; Mayer-Hasselwander, H. A.; Reimer, O.; Sreekumar, P.

1999-01-01

The third EGRET catalog lists 84 sources within 10 deg of the Galactic Plane. Five of these are well-known spin-powered pulsars, 2 and possibly 3 others are blazars, and the remaining 74 are classified as unidentified, although 6 of these are likely to be artifacts of nearby strong sources. Several of the remaining 68 unidentified sources have been noted as having positional agreement with supernovae remnants and OB associations. Others may be radio-quiet pulsars like Geminga, and still others may belong to a totally new class of sources. The question of the energy spectral distributions of these sources is an important clue to their identification. In this paper, the spectra of the sources within 10 deg of Galactic Plane are fit with three different functional forms; a single power law, two power laws, and a power law with an exponential cutoff. Where possible, the best fit is selected with statistical tests. Twelve, and possibly an additional 5 sources, are found to have spectra that are fit by a breaking power law or by the power law with exponential cutoff function.

A Search for FRB 121102-like Persistent Radio-luminous Sources—Candidates and Implications for the FRB Rate and Searches

NASA Astrophysics Data System (ADS)

Ofek, Eran O.

2017-09-01

The localization of the repeating fast radio burst (FRB), FRB 121102, suggests that it is associated with a persistent radio-luminous compact source in the FRB host galaxy. Using the FIRST radio catalog, I present a search for luminous persistent sources in nearby galaxies, with radio luminosities > 10 % of the FRB 121102 persistent source luminosity. The galaxy sample contains about 30% of the total galaxy g-band luminosity within < 108 Mpc, in a footprint of 10,600 deg2. After rejecting sources likely due to active galactic nuclei activity or background sources, I am left with 11 candidates that are presumably associated with galactic disks or star-formation regions. At least some of these candidates are likely to be due to chance alignment. In addition, I find 85 sources within 1\\prime\\prime of galactic nuclei. Assuming that the radio persistent sources are not related to galactic nuclei and that they follow the galaxy g-band light, the 11 sources imply a 95% confidence upper limit on the space density of luminous persistent sources of ≲ 5× {10}-5 Mpc-3, and that at any given time only a small fraction of galaxies host a radio-luminous persistent source (≲ {10}-3 {L}* -1). Assuming a persistent source lifetime of 100 years, this implies a birth rate of ≲ 5× {10}-7 yr-1 Mpc-3. Given the FRB volumetric rate, and assuming that all FRBs repeat and are associated with persistent radio sources, this sets a lower limit on the rate of FRB events per persistent source of ≳ 0.8 yr-1. I argue that these 11 candidates are good targets for FRB searches and I estimate the FRB event rate from these candidates.

The first Fermi-LAT catalog of sources above 10 GeV

DOE PAGES

Ackermann, M.; Ajello, M.; Allafort, A.; ...

2013-11-14

Here, we present a catalog of γ-ray sources at energies above 10 GeV based on data from the Large Area Telescope (LAT) accumulated during the first 3 yr of the Fermi Gamma-ray Space Telescope mission. The first Fermi-LAT catalog of >10 GeV sources (1FHL) has 514 sources. For each source we present location, spectrum, a measure of variability, and associations with cataloged sources at other wavelengths. We found that 449 (87%) could be associated with known sources, of which 393 (76% of the 1FHL sources) are active galactic nuclei. Of the 27 sources associated with known pulsars, we find 20more » (12) to have significant pulsations in the range >10 GeV (>25 GeV). In this work we also report that, at energies above 10 GeV, unresolved sources account for 27% ± 8% of the isotropic γ-ray background, while the unresolved Galactic population contributes only at the few percent level to the Galactic diffuse background. We also highlight the subset of the 1FHL sources that are best candidates for detection at energies above 50-100 GeV with current and future ground-based γ-ray observatories.« less

The First Fermi-LAT Catalog of Sources Above 10 GeV

NASA Technical Reports Server (NTRS)

Ackermann, M.; Ajello, M.; Allafort, A.; Atwood, W. B.; Baldini, L.; Ballet, J.; Barbiellini, G.; Bastieri, D.; Bechtol, K.; Moiseev, Alexander A.

2013-01-01

We present a catalog of gamma-ray sources at energies above 10 GeV based on data from the Large Area Telescope (LAT) accumulated during the first 3 yr of the Fermi Gamma-ray Space Telescope mission. The first Fermi-LAT catalog of >10 GeV sources (1FHL) has 514 sources. For each source we present location, spectrum, a measure of variability, and associations with cataloged sources at other wavelengths. We found that 449 (87%) could be associated with known sources, of which 393 (76% of the 1FHL sources) are active galactic nuclei. Of the 27 sources associated with known pulsars, we find 20 (12) to have significant pulsations in the range >10 GeV (>25 GeV). In this work we also report that, at energies above 10 GeV, unresolved sources account for 27% +/- 8% of the isotropic ? -ray background, while the unresolved Galactic population contributes only at the few percent level to the Galactic diffuse background. We also highlight the subset of the 1FHL sources that are best candidates for detection at energies above 50-100 GeV with current and future ground-based ? -ray observatories.

Genetic variants determining body fat distribution and sex hormone-binding globulin among Chinese female young adults.

PubMed

Shi, Juan; Li, Lijuan; Hong, Jie; Qi, Lu; Cui, Bin; Gu, Weiqiong; Zhang, Yifei; Miao, Lin; Wang, Rui; Wang, Weiqing; Ning, Guang

2014-11-01

Measures of body fat distribution (i.e. waist : hip ratio [WHR]) are major risk factors for diabetes, independent of overall adiposity. The genetic variants related to body fat distribution show sexual dimorphism and particularly affect females. Substantial literature supports a role for sex hormone-binding globulin (SHBG) in the maintenance of glucose homeostasis. The aim of the present study was to examine the association of the genetic risk score of body fat distribution with SHBG levels and insulin resistance in young (14-30 years) Chinese females. In all, 675 young Chinese females were evaluated in the present study. A genetic risk score (GRS) was calculated on the basis of 12 established variants associated with body fat distribution. The main outcome variable was serum SHBG levels and homeostasis model assessment of insulin resistance (HOMA-IR). The GRS of body fat distribution was significantly associated with decreasing serum SHBG levels (P = 0.018), independent of body mass index and WHR. In addition, the GRS and SHBG showed additive effects on HOMA-IR (P = 0.004). The GRS of body fat distribution reflects serum SHBG levels, and the GRS and SHBG jointly influence the risk of insulin resistance. © 2014 Ruijin Hospital, Shanghai Jiaotong University School of Medicine and Wiley Publishing Asia Pty Ltd.

Transient Events in Archival Very Large Array Observations of the Galactic Center

NASA Astrophysics Data System (ADS)

Chiti, Anirudh; Chatterjee, Shami; Wharton, Robert; Cordes, James; Lazio, T. Joseph W.; Kaplan, David L.; Bower, Geoffrey C.; Croft, Steve

2016-12-01

The Galactic center has some of the highest stellar densities in the Galaxy and a range of interstellar scattering properties, which may aid in the detection of new radio-selected transient events. Here, we describe a search for radio transients in the Galactic center, using over 200 hr of archival data from the Very Large Array at 5 and 8.4 GHz. Every observation of Sgr A* from 1985 to 2005 has been searched using an automated processing and detection pipeline sensitive to transients with timescales between 30 s and 5 minutes with a typical detection threshold of ˜100 mJy. Eight possible candidates pass tests to filter false-positives from radio-frequency interference, calibration errors, and imaging artifacts. Two events are identified as promising candidates based on the smoothness of their light curves. Despite the high quality of their light curves, these detections remain suspect due to evidence of incomplete subtraction of the complex structure in the Galactic center, and apparent contingency of one detection on reduction routines. Events of this intensity (˜100 mJy) and duration (˜100 s) are not obviously associated with known astrophysical sources, and no counterparts are found in data at other wavelengths. We consider potential sources, including Galactic center pulsars, dwarf stars, sources like GCRT J1745-3009, and bursts from X-ray binaries. None can fully explain the observed transients, suggesting either a new astrophysical source or a subtle imaging artifact. More sensitive multiwavelength studies are necessary to characterize these events, which, if real, occur with a rate of {14}-12+32 {{hr}}-1 {\\deg }-2 in the Galactic center.

Entire Sky

NASA Image and Video Library

1999-12-01

Aitoff projection of the three-color composite JHKs source count map of the entire sky, based on 95,851,173 stars with Ks 13.5. What appears most prominently are the Galactic plane and the Galactic bulge.

Simulating deep surveys of the Galactic Plane with the Advanced Gamma-ray Imaging System (AGIS)

NASA Astrophysics Data System (ADS)

Funk, Stefan; Digel, Seth

2009-05-01

The pioneering survey of the Galactic plane by H.E.S.S., together with the northern complement now underway with VERITAS, has shown the inner Milky Way to be rich in TeV-emitting sources; new source classes have been found among the H.E.S.S. detections and unidentified sources remain. In order to explore optimizations of the design of an Advanced Gamma-ray Imaging System (AGIS)-like instrument for survey science, we constructed a model of the flux and size distributions of Galactic TeV sources, normalized to the H.E.S.S. sources but extrapolated to lower flux levels. We investigated potential outcomes from a survey with the order of magnitude improvement in sensitivity and attendant improvement in angular resolution planned for AGIS. Studies of individual sources and populations found with such a sensitivity survey will advance understanding of astrophysical particle acceleration, source populations, and even high-energy cosmic rays via detection of the low-level TeV diffuse emission in regions of high cosmic-ray densitiy.

Microlensing optical depth towards the Galactic Bulge using bright sources from OGLE-II

NASA Astrophysics Data System (ADS)

Sumi, T.; Woźniak, P.; Udalski, A.; Szymański, M.; Kubiak, M.; Pietrzyński, G.; Soszyński, I.; Zebruń, K.; Szewczyk, O.; Wyrzykowski, L.

2004-12-01

We present a measurement of the microlensing optical depth towards the Galactic Bulge by using bright stars as sources from the central 20 OGLE-II Galactic bulge fields covering a range of 0o

Observations of Galactic gamma-radiation with the SMM spectrometer

NASA Technical Reports Server (NTRS)

Share, G. H.; Kinzer, R. L.; Messina, D. C.; Purcell, W. R.; Chupp, E. L.

1986-01-01

Preliminary results from the SMM gamma-ray spectrometer are reported which indicate the detection of a constant source of 0.511-MeV annihilation radiation from the Galaxy. Year-to-year variability appears to be less than 30 percent. The radiation probably comes from a diffuse source and is not associated with the reported compact object at the Galactic center.

Cosmic gamma-ray bursts from BATSE - Another great debate

NASA Technical Reports Server (NTRS)

Hartmann, Dieter H.; The, Lih-Sin; Clayton, Donald D.; Schnepf, Neil G.; Linder, Eric V.

1992-01-01

The BATSE detectors aboard Compton Observatory record about one cosmic gamma-ray burst (GRB) per day. Preliminary data analysis shows a highly isotropic sky map and a nonuniform brightness distribution. Anisotropies expected from a Galactic neutron star population, the most frequently considered source model, did not emerge from the data. Taken at face value, the data seem to suggest a heliocentric solution of the GRB puzzle. The observed isotropy can be achieved if sources are either very near or extragalactic. Pop I neutron stars in the disk do not simultaneously fit sky and brightness distributions. A possibility are sources in an extended Galactic halo with scale length large enough to avoid strong anisotropies due to the solar offset from the Galactic center. If GRBs are located in an extended halo we ask whether the neutron star paradigm can survive. We show that the recently discovered high velocity radio pulsars may provide a natural source population for GRBs. If these pulsars formed in the halo, as suggested by the radio data, the possibility arises that GRBs and high velocity pulsars are two related phenomena that provide observational evidence of the dark Galactic corona. We also discuss cosmological redshift constraints that follow from the observed brightness distribution.

X-ray astronomy from Uhuru to HEAO-1

NASA Technical Reports Server (NTRS)

Clark, G. W.

1981-01-01

The nature of galactic and extragalactic X-ray sources is investigated using observations made with nine satellites and several rockets. The question of X-ray pulsars being neutron stars or white dwarfs is considered, as is the nature of Population II and low-luminosity X-ray stars, the diffuse X-ray emission from clusters of galaxies, the unidentified high-galactic-latitude (UHGL) sources, and the unresolved soft X-ray background. The types of sources examined include binary pulsars, Population II X-ray stars (both nonbursters and bursters) inside and outside globular clusters, coronal X-ray emitters, and active galactic nuclei. It is concluded that: (1) X-ray pulsars are strongly magnetized neutron stars formed in the evolution of massive close binaries; (2) all Population II X-ray stars are weakly magnetized or nonmagnetic neutron stars accreting from low-mass companions in close binary systems; (3) the diffuse emission from clusters is thermal bremsstrahlung of hot matter processed in stars and swept out by ram pressure exerted by the intergalactic gas; (4) most or all of the UHGL sources are active galactic nuclei; and (5) the soft X-ray background is emission from a hot component of the interstellar medium.

X-ray bursters and the X-ray sources of the galactic bulge

NASA Technical Reports Server (NTRS)

Lewin, W. H. G.; Joss, P. C.

1980-01-01

Type 1 X-ray bursts, optical, infrared, and radio properties of the galactic bulge sources, are discussed. It was proven that these burst sources are neutron stars in low mass, close binary stellar systems. Several burst sources are found in globular clusters with high central densities. Optical type 1 X-ray bursts were observed from three sources. Type 2 X-ray bursts, observed from the Rapid Burster, are due to an accretion instability which converts gravitational potential energy into heat and radiation, which makes them of a fundamentally different nature from Type 1 bursts.

Streamlined Genome Sequence Compression using Distributed Source Coding

PubMed Central

Wang, Shuang; Jiang, Xiaoqian; Chen, Feng; Cui, Lijuan; Cheng, Samuel

2014-01-01

We aim at developing a streamlined genome sequence compression algorithm to support alternative miniaturized sequencing devices, which have limited communication, storage, and computation power. Existing techniques that require heavy client (encoder side) cannot be applied. To tackle this challenge, we carefully examined distributed source coding theory and developed a customized reference-based genome compression protocol to meet the low-complexity need at the client side. Based on the variation between source and reference, our protocol will pick adaptively either syndrome coding or hash coding to compress subsequences of changing code length. Our experimental results showed promising performance of the proposed method when compared with the state-of-the-art algorithm (GRS). PMID:25520552

Hard X-ray observations of the region from the galactic center to Centaurus

NASA Technical Reports Server (NTRS)

Guo, D. D.; Webber, W. R.; Damle, S. V.

1974-01-01

A balloon flight from Parana, Argentina, was conducted to observe emissions from discrete or extended sources in the southern sky. The sources observed include GX 304-1, Nor X-2, GX 340+0, GX 354-5, a possibly composite source near the galactic center, and the nova-like source (2U1543-47) in the Lupus-Norma region which has been reported previously only in satellite observations. Data concerning the possibility of line emission near 0.5 MeV from different regions of the southern sky are also presented.

Gamma-ray burst constraints on the galactic frequency of extrasolar Oort Clouds

NASA Technical Reports Server (NTRS)

Shull, J. Michael; Stern, S. Alan

1995-01-01

With the strong Compton Gamma-Ray Observatory/Burst and Transient Source Experiment (CGRO/BATSE) evidence that most gamma-ray bursts do not come from galactic neutron stars, models involving the accretion of a comet onto a neutron star (NS) no longer appear to be strong contenders for explaining the majority of bursts. If this is the case, then it is worth asking whether the lack of an observed galactic gamma-ray burst population provides a useful constraint on the number of comets and comet clouds in the galaxy. Owing to the previously unrecognized structural weakness of cometary nuclei, we find the capture cross sections for comet-NS events to be much higher than previously published estimates, with tidal breakup at distances R(sub b) approx. equals 4 x 10(exp 10) cm from the NS. As a result, impacts of comets onto field NSs penetrating the Oort Clouds of other stars are found to dominate all other galactic NS-comet capture rates by a factor of 100. This in turn predicts that if comet clouds are common, there should be a significant population of repeater sources with (1) a galactic distribution, (2) space-correlated repetition, and (3) a wide range of peak luminosities and luminosity time histories. If all main sequence stars have Oort Clouds like our own, we predict approximately 4000 such repeater sources in the Milky Way at any time, each repeating on time scales of months to years. Based on estimates of the sensitivity of the CGRO/BATSE instrument and assuming isotropic gamma-ray beaming from such events, we estimate that a population of approximately 20-200 of these galactic NS-Oort Cloud gamma-ray repeater sources should be detectable by CGRO. In addition, if giant planet formation is common in the galaxy, we estimate that the accretion of isolated comets injected to the interstellar medium by giant planet formation should produce an additional source of galactic, nonrepeating, events. Comparing these estimates to the 3-4 soft gamma-ray repeater sources detected by BATSE, one is forced to conclude that (1) comet impacts on NSs are inefficient at producing gamma rays; or (2) the gamma rays from such events are highly beamed; or (3) the fraction of stars in the galaxy with Oort Clouds like our own is not higher than a few percent.

Galactic gamma-ray sources, SNOBs, and giant H2 regions

NASA Technical Reports Server (NTRS)

Montmerle, T.

1985-01-01

Progress towards understanding the nature of the COS-B galactic gamma-ray sources was made by two recent developments. The developments are: (1) the existence of extensive wide-latitude CO surveys, from the Northern Hemisphere, and from the Southern Hemisphere which give more precise information on molecular cloud population of the Perseus, Sagittarius, and Carina spiral arms; (2) the study of the time variability of gamma-ray sources in gamma-rays but also at other wavelengths, leading to the discovery of four new variable sources in addition to the already known Crab and Vela pulsars. Three classes of gamma-ray sources are found; invariable sources, active sources, and passive sources.

Installation summary report : GRS instrumentation I-70 over Smith Road.

DOT National Transportation Integrated Search

2016-07-04

This report presents a summary of the I-70 over Smith Road GRS Instrumentation Project (the project) in Aurora, Colorado. The report summarizes the instruments used, installation means and methods, and a discussion on the web-based data interface. CD...

77 FR 62482 - Fisheries of the Exclusive Economic Zone Off Alaska; Bering Sea and Aleutian Islands Management...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-15

.../ Ps and Amendment 80 cooperatives from undue compliance costs stemming from the mandatory GRS rates... estimates may stem from differences in the data used in the analysis for the GRS program to calculate the...

Instrumentation and monitoring of rustic road geosynthetic reinforced soil (GRS) integrated bridge system (IBS).

DOT National Transportation Integrated Search

2016-11-01

J. Erik Loehr ; orcid.org/0000-0001-6035-8416 : An instrumentation and monitoring system was implemented for a geosynthetic reinforced soil (GRS) integrated bridge : system (IBS) constructed in Boone County, Missouri in 2014. The project location is ...

The Identification of EGRET Sources with Flat-Spectrum Radio Sources

NASA Astrophysics Data System (ADS)

Mattox, J. R.; Schachter, J.; Molnar, L.; Hartman, R. C.; Patnaik, A. R.

1997-05-01

We present a method to assess the reliability of the identification of EGRET sources with extragalactic radio sources. We verify that EGRET is detecting the blazar class of active galactic nuclei (AGNs). However, many published identifications are found to be questionable. We provide a table of 42 blazars that we expect to be robust identifications of EGRET sources. This includes one previously unidentified EGRET source, the lensed AGN PKS 1830-210, near the direction of the Galactic center. We provide the best available positions for 16 more radio sources that are also potential identifications for previously unidentified EGRET sources. All high Galactic latitude EGRET sources (|b| > 3°) that demonstrate significant variability can be identified with flat-spectrum radio sources. This suggests that EGRET is not detecting any type of AGN other than blazars. This identification method has been used to establish with 99.998% confidence that the peak γ-ray flux of a blazar is correlated with its average 5 GHz radio flux. An even better correlation is seen between γ-ray flux and the 2.29 GHz flux density measured with VLBI at the base of the radio jet. Also, using high-confidence identifications, we find that the radio sources identified with EGRET sources have greater correlated VLBI flux densities than the parent population of flat radio spectrum sources.

Disclosing Genetic Risk for Coronary Heart Disease: Attitudes Toward Personal Information in Health Records.

PubMed

Brown, Sherry-Ann; Jouni, Hayan; Marroush, Tariq S; Kullo, Iftikhar J

2017-04-01

Incorporating genetic risk information in electronic health records (EHRs) will facilitate implementation of genomic medicine in clinical practice. However, little is known about patients' attitudes toward incorporation of genetic risk information as a component of personal health information in EHRs. This study investigated whether disclosure of a genetic risk score (GRS) for coronary heart disease influences attitudes toward incorporation of personal health information including genetic risk in EHRs. Participants aged 45-65 years with intermediate 10-year coronary heart disease risk were randomized to receive a conventional risk score (CRS) alone or with a GRS from a genetic counselor, followed by shared decision making with a physician using the same standard presentation and information templates for all study participants. The CRS and GRS were then incorporated into the EHR and made accessible to both patients and physicians. Baseline and post-disclosure surveys were completed to assess whether attitudes differed by GRS disclosure. Data were collected from 2013 to 2015 and analyzed in 2015-2016. GRS and CRS participants reported similar positive attitudes toward incorporation of genetic risk information in the EHR. Compared with CRS participants, participants with high GRS were more concerned about the confidentiality of genetic risk information (OR=3.67, 95% CI=1.29, 12.32, p=0.01). Post-disclosure, frequency of patient portal access was associated with positive attitudes. Participants in this study of coronary heart disease risk disclosure overall had positive attitudes toward incorporation of genetic risk information in EHRs, although those who received genetic risk information had concerns about confidentiality. Copyright © 2016 American Journal of Preventive Medicine. Published by Elsevier Inc. All rights reserved.

Genetic Variations of Circulating Adiponectin Levels Modulate Changes in Appetite in Response to Weight-Loss Diets

PubMed Central

Ma, Wenjie; Huang, Tao; Heianza, Yoriko; Wang, Tiange; Sun, Dianjianyi; Tong, Jenny; Williamson, Donald A.; Bray, George A.; Sacks, Frank M.

2017-01-01

Context: Adiponectin plays key roles in regulating appetite and food intake. Objective: To investigate interactions between the genetic risk score (GRS) for adiponectin levels and weight-loss diets varying in macronutrient intake on long-term changes in appetite and adiponectin levels. Design, Setting, and Participants: A GRS was calculated based on 5 adiponectin-associated variants in 692 overweight adults from the 2-year Preventing Overweight Using Novel Dietary Strategies trial. Main Outcome Measures: Repeated measurements of plasma adiponectin levels and appetite-related traits, including cravings, fullness, prospective consumption, and hunger. Results: Dietary fat showed nominally significant interactions with the adiponectin GRS on changes in appetite score and prospective consumption from baseline to 6 months (P for interaction = 0.014 and 0.017, respectively) after adjusting for age, sex, ethnicity, baseline body mass index, and baseline respective outcome values. The GRS for lower adiponectin levels was associated with a greater decrease in appetite (P < 0.001) and prospective consumption (P = 0.008) among participants consuming a high-fat diet, whereas no significant associations were observed in the low-fat group. Additionally, a significant interaction was observed between the GRS and dietary fat on 6-month changes in adiponectin levels (P for interaction = 0.021). The lower GRS was associated with a greater increase in adiponectin in the low-fat group (P = 0.02), but it was not associated with adiponectin changes in the high-fat group (P = 0.31). Conclusions: Our findings suggest that individuals with varying genetic architecture of circulating adiponectin may respond divergently in appetite and adiponectin levels to weight-loss diets varying in fat intake. PMID:27841942

Prospective associations of C-reactive protein (CRP) levels and CRP genetic risk scores with risk of total knee and hip replacement for osteoarthritis in a diverse cohort.

PubMed

Shadyab, A H; Terkeltaub, R; Kooperberg, C; Reiner, A; Eaton, C B; Jackson, R D; Krok-Schoen, J L; Salem, R M; LaCroix, A Z

2018-05-22

To examine associations of high-sensitivity C-reactive protein (CRP) levels and polygenic CRP genetic risk scores (GRS) with risk of end-stage hip or knee osteoarthritis (OA), defined as incident total hip (THR) or knee replacement (TKR) for OA. This study included a cohort of postmenopausal white, African American, and Hispanic women from the Women's Health Initiative. Women were followed from baseline to date of THR or TKR, death, or December 31, 2014. Medicare claims data identified THR and TKR. Hs-CRP and genotyping data were collected at baseline. Three CRP GRS were constructed: 1) a 4-SNP GRS comprised of genetic variants representing variation in the CRP gene among European populations; 2) a multilocus 18-SNP GRS of genetic variants significantly associated with CRP levels in a meta-analysis of genome-wide association studies; and 3) a 5-SNP GRS of genetic variants significantly associated with CRP levels among African American women. In analyses conducted separately among each race and ethnic group, there were no significant associations of ln hs-CRP with risk of THR or TKR, after adjusting for age, body mass index, lifestyle characteristics, chronic diseases, hormone therapy use, and non-steroidal anti-inflammatory drug use. CRP GRS were not associated with risk of THR or TKR in any ethnic group. Serum levels of ln hs-CRP and genetically-predicted CRP levels were not associated with risk of THR or TKR for OA among a diverse cohort of women. Copyright © 2018 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.

A genetic risk score based on direct associations with coronary heart disease improves coronary heart disease risk prediction in the Atherosclerosis Risk in Communities (ARIC), but not in the Rotterdam and Framingham Offspring, Studies

PubMed Central

Brautbar, Ariel; Pompeii, Lisa A.; Dehghan, Abbas; Ngwa, Julius S.; Nambi, Vijay; Virani, Salim S.; Rivadeneira, Fernando; Uitterlinden, André G.; Hofman, Albert; Witteman, Jacqueline C.M.; Pencina, Michael J.; Folsom, Aaron R.; Cupples, L. Adrienne; Ballantyne, Christie M.; Boerwinkle, Eric

2013-01-01

Objective Multiple studies have identified single-nucleotide polymorphisms (SNPs) that are associated with coronary heart disease (CHD). We examined whether SNPs selected based on predefined criteria will improve CHD risk prediction when added to traditional risk factors (TRFs). Methods SNPs were selected from the literature based on association with CHD, lack of association with a known CHD risk factor, and successful replication. A genetic risk score (GRS) was constructed based on these SNPs. Cox proportional hazards model was used to calculate CHD risk based on the Atherosclerosis Risk in Communities (ARIC) and Framingham CHD risk scores with and without the GRS. Results The GRS was associated with risk for CHD (hazard ratio [HR] = 1.10; 95% confidence interval [CI]: 1.07–1.13). Addition of the GRS to the ARIC risk score significantly improved discrimination, reclassification, and calibration beyond that afforded by TRFs alone in non-Hispanic whites in the ARIC study. The area under the receiver operating characteristic curve (AUC) increased from 0.742 to 0.749 (Δ= 0.007; 95% CI, 0.004–0.013), and the net reclassification index (NRI) was 6.3%. Although the risk estimates for CHD in the Framingham Offspring (HR = 1.12; 95% CI: 1.10–1.14) and Rotterdam (HR = 1.08; 95% CI: 1.02–1.14) Studies were significantly improved by adding the GRS to TRFs, improvements in AUC and NRI were modest. Conclusion Addition of a GRS based on direct associations with CHD to TRFs significantly improved discrimination and reclassification in white participants of the ARIC Study, with no significant improvement in the Rotterdam and Framingham Offspring Studies. PMID:22789513

Circadian clock-related genetic risk scores and risk of placental abruption.

PubMed

Qiu, Chunfang; Gelaye, Bizu; Denis, Marie; Tadesse, Mahlet G; Luque Fernandez, Miguel Angel; Enquobahrie, Daniel A; Ananth, Cande V; Sanchez, Sixto E; Williams, Michelle A

2015-12-01

The circadian clock plays an important role in several aspects of female reproductive biology. Evidence linking circadian clock-related genes to pregnancy outcomes has been inconsistent. We sought to examine whether variations in single nucleotide polymorphisms (SNPs) of circadian clock genes are associated with PA risk. Maternal blood samples were collected from 470 PA case and 473 controls. Genotyping was performed using the Illumina Cardio-MetaboChip platform. We examined 119 SNPs in 13 candidate genes known to control circadian rhythms (e.g., CRY2, ARNTL, and RORA). Univariate and penalized logistic regression models were fit to estimate odds ratios (ORs); and the combined effect of multiple SNPs on PA risk was estimated using a weighted genetic risk score (wGRS). A common SNP in the RORA gene (rs2899663) was associated with a 21% reduced odds of PA (P < 0.05). The odds of PA increased with increasing wGRS (Ptrend < 0.001). The corresponding ORs were 1.00, 1.83, 2.81 and 5.13 across wGRS quartiles. Participants in the highest wGRS quartile had a 5.13-fold (95% confidence interval: 3.21-8.21) higher odds of PA compared to those in the lowest quartile. Although the test for interaction was not significant, the odds of PA was substantially elevated for preeclamptics with the highest wGRS quartile (OR = 14.44, 95%CI: 6.62-31.53) compared to normotensive women in the lowest wGRS quartile. Genetic variants in circadian rhythm genes may be associated with PA risk. Larger studies are needed to corroborate these findings and to further elucidate the pathogenesis of this important obstetrical complication. Copyright © 2015 Elsevier Ltd. All rights reserved.

Lifestyle Cardiovascular Risk Score, Genetic Risk Score, and Myocardial Infarction in Hispanic/Latino Adults Living in Costa Rica.

PubMed

Sotos-Prieto, Mercedes; Baylin, Ana; Campos, Hannia; Qi, Lu; Mattei, Josiemer

2016-12-20

A lifestyle cardiovascular risk score (LCRS) and a genetic risk score (GRS) have been independently associated with myocardial infarction (MI) in Hispanics/Latinos. Interaction or joint association between these scores has not been examined. Thus, our aim was to assess interactive and joint associations between LCRS and GRS, and each individual lifestyle risk factor, on likelihood of MI. Data included 1534 Costa Rican adults with nonfatal acute MI and 1534 matched controls. The LCRS used estimated coefficients as weights for each factor: unhealthy diet, physical inactivity, smoking, elevated waist:hip ratio, low/high alcohol intake, low socioeconomic status. The GRS included 14 MI-associated risk alleles. Conditional logistic regressions were used to calculate adjusted odds ratios. The odds ratios for MI were 2.72 (2.33, 3.17) per LCRS unit and 1.13 (95% CI 1.06, 1.21) per GRS unit. A significant joint association for highest GRS tertile and highest LCRS tertile and odds of MI was detected (odds ratio=5.43 [3.71, 7.94]; P<1.00×10 -7 ), compared to both lowest tertiles. The odds ratios were 1.74 (1.22, 2.49) under optimal lifestyle and unfavorable genetic profile, and 5.02 (3.46, 7.29) under unhealthy lifestyle but advantageous genetic profile. Significant joint associations were observed for the highest GRS tertile and the highest of each lifestyle component risk category. The interaction term was nonsignificant (P=0.33). Lifestyle risk factors and genetics are jointly associated with higher odds of MI among Hispanics/Latinos. Individual and combined lifestyle risk factors showed stronger associations. Efforts to improve lifestyle behaviors could help prevent MI regardless of genetic susceptibility. © 2016 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell.

DEVELOPMENT OF THE MODEL OF GALACTIC INTERSTELLAR EMISSION FOR STANDARD POINT-SOURCE ANALYSIS OF FERMI LARGE AREA TELESCOPE DATA

DOE Office of Scientific and Technical Information (OSTI.GOV)

Acero, F.; Ballet, J.; Ackermann, M.

2016-04-01

Most of the celestial γ rays detected by the Large Area Telescope (LAT) on board the Fermi Gamma-ray Space Telescope originate from the interstellar medium when energetic cosmic rays interact with interstellar nucleons and photons. Conventional point-source and extended-source studies rely on the modeling of this diffuse emission for accurate characterization. Here, we describe the development of the Galactic Interstellar Emission Model (GIEM), which is the standard adopted by the LAT Collaboration and is publicly available. This model is based on a linear combination of maps for interstellar gas column density in Galactocentric annuli and for the inverse-Compton emission producedmore » in the Galaxy. In the GIEM, we also include large-scale structures like Loop I and the Fermi bubbles. The measured gas emissivity spectra confirm that the cosmic-ray proton density decreases with Galactocentric distance beyond 5 kpc from the Galactic Center. The measurements also suggest a softening of the proton spectrum with Galactocentric distance. We observe that the Fermi bubbles have boundaries with a shape similar to a catenary at latitudes below 20° and we observe an enhanced emission toward their base extending in the north and south Galactic directions and located within ∼4° of the Galactic Center.« less

Development of the Model of Galactic Interstellar Emission for Standard Point-Source Analysis of Fermi Large Area Telescope Data

NASA Technical Reports Server (NTRS)

Acero, F.; Ackermann, M.; Ajello, M.; Albert, A.; Baldini, L.; Ballet, J.; Barbiellini, G.; Bastieri, D.; Bellazzini, R.; Brandt, T. J.;

A Green Bank Telescope Survey of Large Galactic H II Regions

NASA Astrophysics Data System (ADS)

Anderson, L. D.; Armentrout, W. P.; Luisi, Matteo; Bania, T. M.; Balser, Dana S.; Wenger, Trey V.

2018-02-01

As part of our ongoing H II Region Discovery Survey (HRDS), we report the Green Bank Telescope detection of 148 new angularly large Galactic H II regions in radio recombination line (RRL) emission. Our targets are located at a declination of δ > -45^\\circ , which corresponds to 266^\\circ > {\\ell }> -20^\\circ at b=0^\\circ . All sources were selected from the Wide-field Infrared Survey Explorer Catalog of Galactic H II Regions, and have infrared angular diameters ≥slant 260\\prime\\prime . The Galactic distribution of these “large” H II regions is similar to that of the previously known sample of Galactic H II regions. The large H II region RRL line width and peak line intensity distributions are skewed toward lower values, compared with that of previous HRDS surveys. We discover seven sources with extremely narrow RRLs < 10 {km} {{{s}}}-1. If half the line width is due to turbulence, these seven sources have thermal plasma temperatures < 1100 {{K}}. These temperatures are lower than any measured for Galactic H II regions, and the narrow-line components may arise instead from partially ionized zones in the H II region photodissociation regions. We discover G039.515+00.511, one of the most luminous H II regions in the Galaxy. We also detect the RRL emission from three H II regions with diameters > 100 {pc}, making them some of the physically largest known H II regions in the Galaxy. This survey completes the HRDS H II region census in the Northern sky, where we have discovered 887 H II regions and more than doubled the size of the previously known census of Galactic H II regions.

Recent high energy gamma-ray results from SAS-2

NASA Technical Reports Server (NTRS)

Thompson, D. J.; Fichtel, C. E.; Hartman, R. C.; Kniffen, D. A.; Bignami, G. F.; Ogelman, H. B.; Ozel, M. E.; Tumer, T.; Lamb, R. C.

1977-01-01

Recent developments in gamma-ray astronomy due to the results from SAS-2 have focused on two areas. First, the emission from the plane of the Galaxy is the dominant feature in the gamma-ray sky. The galactic latitude and longitude distributions are consistent with the concept that the high-energy radiation originates from cosmic rays interacting with interstellar matter, and the measurements support a galactic origin for cosmic rays. Second, searches of the SAS-2 data for emission from localized sources have shown three strong discrete gamma-ray sources: the Crab nebula and PSR 0531 + 21, the Vela supernova remnant and PSR 0833-45, and a source near galactic coordinates 193 deg longitude, +3 deg latitude, which does not appear to be associated with other known celestial objects. Evidence has also been found for pulsed gamma-ray emission from two other radio pulsars, PSR 1818-04 and PSR 1747-46. A localized source near longitudes 76-80 deg may be associated with the X-ray source Cyg X-3.

Monitoring the Galactic - Search for Hard X-Ray Transients

NASA Astrophysics Data System (ADS)

Marshall, Francis

Hard X-ray transients with fluxs from ~1 to ~30 mCrab are a common feature of the galactic plane with apparent concentrations in specific regions of the plane. Concentrations in the Scutum and Carina fields probably indicate an enhancement of Be X-ray binaries along the tangent direction of two spiral arms. The frequency of outbursts suggest that at any one time 1 or 2 transients are active in the Scutum field alone. We propose weekly scans of the galactic plane to understand this population of sources. The scans will also monitor about 50 already known sources with better spectral information than available with the ASM.

THE BOLOCAM GALACTIC PLANE SURVEY. VIII. A MID-INFRARED KINEMATIC DISTANCE DISCRIMINATION METHOD

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ellsworth-Bowers, Timothy P.; Glenn, Jason; Battersby, Cara

2013-06-10

We present a new distance estimation method for dust-continuum-identified molecular cloud clumps. Recent (sub-)millimeter Galactic plane surveys have cataloged tens of thousands of these objects, plausible precursors to stellar clusters, but detailed study of their physical properties requires robust distance determinations. We derive Bayesian distance probability density functions (DPDFs) for 770 objects from the Bolocam Galactic Plane Survey in the Galactic longitude range 7. Degree-Sign 5 {<=} l {<=} 65 Degree-Sign . The DPDF formalism is based on kinematic distances, and uses any number of external data sets to place prior distance probabilities to resolve the kinematic distance ambiguity (KDA)more » for objects in the inner Galaxy. We present here priors related to the mid-infrared absorption of dust in dense molecular regions and the distribution of molecular gas in the Galactic disk. By assuming a numerical model of Galactic mid-infrared emission and simple radiative transfer, we match the morphology of (sub-)millimeter thermal dust emission with mid-infrared absorption to compute a prior DPDF for distance discrimination. Selecting objects first from (sub-)millimeter source catalogs avoids a bias towards the darkest infrared dark clouds (IRDCs) and extends the range of heliocentric distance probed by mid-infrared extinction and includes lower-contrast sources. We derive well-constrained KDA resolutions for 618 molecular cloud clumps, with approximately 15% placed at or beyond the tangent distance. Objects with mid-infrared contrast sufficient to be cataloged as IRDCs are generally placed at the near kinematic distance. Distance comparisons with Galactic Ring Survey KDA resolutions yield a 92% agreement. A face-on view of the Milky Way using resolved distances reveals sections of the Sagittarius and Scutum-Centaurus Arms. This KDA-resolution method for large catalogs of sources through the combination of (sub-)millimeter and mid-infrared observations of molecular cloud clumps is generally applicable to other dust-continuum Galactic plane surveys.« less

Exploring the Hard and Soft X-ray Emission of Magnetic Cataclysmic Variables

NASA Astrophysics Data System (ADS)

de Martino, D.; Anzolin, G.; Bonnet-Bidaud, J.-M.; Falanga, M.; Matt, G.; Mouchet, M.; Mukai, K.; Masetti, N.

2009-05-01

A non-negligible fraction of galactic hard (>20 keV) X-ray sources were identified as CVs of the magnetic Intermediate Polar type in INTEGRAL, SWIFT and RXTE surveys, that suggests a still hidden but potentially important population of faint hard X-ray sources. Simbol-X has the unique potential to simultaneously characterize their variable and complex soft and hard X-ray emission thus allowing to understand their putative role in galactic populations of X-ray sources.

X-ray astronomical spectroscopy

NASA Technical Reports Server (NTRS)

Holt, S. S.

1980-01-01

The current status of the X-ray spectroscopy of celestial X-ray sources, ranging from nearby stars to distant quasars, is reviewed. Particular emphasis is placed on the role of such spectroscopy as a useful and unique tool in the elucidation of the physical parameters of the sources. The spectroscopic analysis of degenerate and nondegenerate stellar systems, galactic clusters and active galactic nuclei, and supernova remnants is discussed.

The isotropic radio background revisited

NASA Astrophysics Data System (ADS)

Fornengo, Nicolao; Lineros, Roberto A.; Regis, Marco; Taoso, Marco

2014-04-01

We present an extensive analysis on the determination of the isotropic radio background. We consider six different radio maps, ranging from 22 MHz to 2.3 GHz and covering a large fraction of the sky. The large scale emission is modeled as a linear combination of an isotropic component plus the Galactic synchrotron radiation and thermal bremsstrahlung. Point-like and extended sources are either masked or accounted for by means of a template. We find a robust estimate of the isotropic radio background, with limited scatter among different Galactic models. The level of the isotropic background lies significantly above the contribution obtained by integrating the number counts of observed extragalactic sources. Since the isotropic component dominates at high latitudes, thus making the profile of the total emission flat, a Galactic origin for such excess appears unlikely. We conclude that, unless a systematic offset is present in the maps, and provided that our current understanding of the Galactic synchrotron emission is reasonable, extragalactic sources well below the current experimental threshold seem to account for the majority of the brightness of the extragalactic radio sky.

Complex organic molecules in the Galactic Centre: the N-bearing family

NASA Astrophysics Data System (ADS)

Zeng, S.; Jiménez-Serra, I.; Rivilla, V. M.; Martín, S.; Martín-Pintado, J.; Requena-Torres, M. A.; Armijos-Abendaño, J.; Riquelme, D.; Aladro, R.

2018-05-01

We present an unbiased spectral line survey toward the Galactic Centre (GC) quiescent giant molecular cloud (QGMC), G+0.693 using the GBT and IRAM 30 telescopes. Our study highlights an extremely rich organic inventory of abundant amounts of nitrogen (N)-bearing species in a source without signatures of star formation. We report the detection of 17 N-bearing species in this source, of which 8 are complex organic molecules (COMs). A comparison of the derived abundances relative to H2 is made across various galactic and extragalactic environments. We conclude that the unique chemistry in this source is likely to be dominated by low-velocity shocks with X-rays/cosmic rays also playing an important role in the chemistry. Like previous findings obtained for O-bearing molecules, our results for N-bearing species suggest a more efficient hydrogenation of these species on dust grains in G+0.693 than in hot cores in the Galactic disk, as a consequence of the low dust temperatures coupled with energetic processing by X-ray/cosmic ray radiation in the GC.

Implications of Fermi-LAT observations on the origin of IceCube neutrinos

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wang, Bin; Li, Zhuo; Zhao, Xiaohong, E-mail: wang_b@pku.edu.cn, E-mail: zhaoxh@ynao.ac.cn, E-mail: zhuo.li@pku.edu.cn

2014-11-01

The IceCube (IC) collaboration recently reported the detection of TeV-PeV extraterrestrial neutrinos whose origin is yet unknown. By the photon-neutrino connection in pp and pγ interactions, we use the Fermi-LAT observations to constrain the origin of the IC detected neutrinos. We find that Galactic origins, i.e., the diffuse Galactic neutrinos due to cosmic ray (CR) propagation in the Milky Way, and the neutrinos from the Galactic point sources, may not produce the IC neutrino flux, thus these neutrinos should be of extragalactic origin. Moreover, the extragalactic gamma-ray bursts (GRBs) may not account for the IC neutrino flux, the jets ofmore » active galactic nuclei may not produce the IC neutrino spectrum, but the starburst galaxies (SBGs) may be promising sources. As suggested by the consistency between the IC detected neutrino flux and the Waxman-Bahcall bound, GRBs in SBGs may be the sources of both the ultrahigh energy, ∼> 10{sup 19}eV, CRs and the 1–100 PeV CRs that produce the IC detected TeV-PeV neutrinos.« less

Galactic cosmic ray composition

NASA Technical Reports Server (NTRS)

Meyer, J. P.

1986-01-01

An assessment is given of the galactic cosmic ray source (GCRS) elemental composition and its correlation with first ionization potential. The isotopic composition of heavy nuclei; spallation cross sections; energy spectra of primary nuclei; electrons; positrons; local galactic reference abundances; comparison of solar energetic particles and solar coronal compositions; the hydrogen; lead; nitrogen; helium; and germanium deficiency problems; and the excess of elements are among the topics covered.

The association between growth rate, body weight, backfat thickness and age at first observed oestrus in crossbred Landrace x Yorkshire gilts.

PubMed

Tummaruk, Padet; Tantasuparuk, Wichai; Techakumphu, Mongkol; Kunavongkrit, Annop

2009-01-01

The present study aims to investigate the association between growth rate (GR), body weight (BW), backfat thickness (BF) and age at first observed oestrus in crossbred Landrace x Yorkshire (LY) replacement gilts in the tropics. The study was carried out on five commercial swine herds in Thailand between 2004 and 2006. A total of 6946 LY gilts were included. The gilts entered the herd at about 163 days of age. The BW (kg) and BF (mm) of the gilts were measured when the gilts entered the gilt pools and again when the gilts were sent to the breeding house. The GR from birth to entry into the gilt pools (birth to 90 kg BW) (GRe), the GR from entry into to exit from the gilt pools (91-134 kg BW) (GRi) and the GR from birth until the gilts were sent to the breeding house (birth to 134 kg BW) (GRs) were calculated. The relationship between age at first observed oestrus and GRe, GRs, GRi, BW and BF were analyzed. Pearson's correlation and four general linear models (GLMs) were conducted. On average, the gilts showed first observed oestrus at 200+/-28 days of age. The means of age at first observed oestrus varied from 188 to 251 days (P<0.001) among the herds. The GRs of the gilts significantly correlated with the BW (r=0.55, P<0.001) of the gilts when they were sent to the breeding house and the age at first observed oestrus (r=-0.40, P<0.001). Gilts with a high GRe and GRs were younger at first observed oestrus compared to gilts with a low GRe and GRs. On average, the gilts with GRs of over 604 g/day showed first observed oestrus before 5 months of age. GRi was not correlated with the age at first observed oestrus (P>0.05). Neither the BF of the gilts at entry nor the BF that the gilts gained within the gilt pools significantly correlated with age at first observed oestrus (P=0.29 and P=0.69, respectively). But the gilts with a higher BF at entry tended to have a higher BW when they were sent to the breeding house (r=0.44, P<0.001). The present study indicates that replacement gilts with a high GR (both GRe and GRs) tend to show sign of oestrus earlier than gilts with a low GR (both GRe and GRs).

Lack of Gene-Diuretic Interactions on the Risk of Incident Gout: the Nurses’ Health Study and Health Professionals Follow-Up Study

PubMed Central

Bao, Ying; Curhan, Gary; Merriman, Tony; Plenge, Robert; Kraft, Peter; Choi, Hyon K.

2015-01-01

Background Diuretic-induced gout might occur only among those with a genetic predisposition to hyperuricemia, as suggested by a recent study with 108 self-reported gout cases. Methods We examined the role of urate genes on the risk of diuretic-induced incident gout in 6850 women from the Nurses’ Health Study (NHS) and in 4,223 men from the Health Professionals Follow-up Study (HPFS). Two published genetic risk scores (GRS) were calculated using urate-associated SNPs for eight genes (GRS8) and for 29 genes (GRS29). Results Our analyses included 727 and 354 confirmed incident gout cases in the HPFS and NHS, respectively. The multivariate RR for diuretic use was 2.20 and 1.69 among those with a GRS8 < and ≥ the median (p for interaction=0.27). The corresponding RRs using GRS29 were 2.19 and 1.88 (p for interaction=0.40). The lack of interaction persisted in the NHS (all p values >0.20) and in our analyses limited to those with hypertension in both cohorts. SLC22A11 (OAT4) showed a significant interaction only among women but in the opposite direction to the recent study. Conclusion In these large prospective studies, individuals with a genetic predisposition for hyperuricemia are not at a higher risk of developing diuretic-induced gout than those without. PMID:25667207

Characterization of Jupiter's Atmosphere from Galileo and Earth-Based Observations During the Ganymede-1 and Ganymede-2 Orbit Encounters

NASA Astrophysics Data System (ADS)

Orton, G.; Fisher, B.; Ortiz, J. L.; Yanamandra-Fisher, P.; Rages, K.; Howell, R.; Klebe, D.; Stencel, R.; Drossart, P.; Lecacheux, J.; Colas, F.; Frappa, E.; Hernandez, C.; Parker, D.; Miyazaki, I.; Stewart, S.; Stansberry, J.; Spencer, J.; Golisch, W.; Griep, D.; Hainaut, M.-C.; Joseph, R.; Kaminski, C.; Banjevic, M.; Connor, C.; Hinkley, S.; Marinova, M.; Marriage, B.; Dobrea, E. Noe

1996-09-01

Galileo remote sensing data are examined in the context of an extensive set of earth-based observations supporting the Ganymede-1 and Ganymede-2 encounters. Movies of the Great Red Spot (GRS) in reflected sunlight, show large-scale flow; for example, the circular feature northwest of the GRS during G1 was one of several high-altitude systems moving westward with respect to the GRS. The southern part of the clear band surrounding the GRS was narrower at 5 mu m than 8.57 mu m, suggesting more cloud cover at depth than at the NH_3 condensation level; this region was also warmer in the troposphere. High-altitude particles were found in the flow pattern ``trailing'' the GRS. The real-time NIMS G1 spectra sampled a region only moderately bright at 5-mu m, not a classical ``hot spot''. Synoptic middle-infrared spectra of this region complement NIMS spectra of the deep troposphere by constraining abundances of NH_3 and PH_3 at higher altitudes. The southern part of the North Equatorial Belt, observed by both NIMS spectra and PPR radiometry, was very active, generating classical bright ``plumes'' and dark ovals (``barges'') for the first time in many months. A long-term program will continue to observe potential targets for the Galileo's atmospheric investigation.

Evolution of Gustatory Receptor Gene Family Provides Insights into Adaptation to Diverse Host Plants in Nymphalid Butterflies.

PubMed

Suzuki, Hiromu C; Ozaki, Katsuhisa; Makino, Takashi; Uchiyama, Hironobu; Yajima, Shunsuke; Kawata, Masakado

2018-06-01

The host plant range of herbivorous insects is a major aspect of insect-plant interaction, but the genetic basis of host range expansion in insects is poorly understood. In butterflies, gustatory receptor genes (GRs) play important roles in host plant selection by ovipositing females. Since several studies have shown associations between the repertoire sizes of chemosensory gene families and the diversity of resource use, we hypothesized that the increase in the number of genes in the GR family is associated with host range expansion in butterflies. Here, we analyzed the evolutionary dynamics of GRs among related species, including the host generalist Vanessa cardui and three specialists. Although the increase of the GR repertoire itself was not observed, we found that the gene birth rate of GRs was the highest in the lineage leading to V. cardui compared with other specialist lineages. We also identified two taxon-specific subfamilies of GRs, characterized by frequent lineage-specific duplications and higher non-synonymous substitution rates. Together, our results suggest that frequent gene duplications in GRs, which might be involved in the detection of plant secondary metabolites, were associated with host range expansion in the V. cardui lineage. These evolutionary patterns imply that the capability to perceive various compounds during host selection was favored during adaptation to diverse host plants.

Chromophores from photolyzed ammonia reacting with acetylene: Application to Jupiter's Great Red Spot

NASA Astrophysics Data System (ADS)

Carlson, R. W.; Baines, K. H.; Anderson, M. S.; Filacchione, G.; Simon, A. A.

2016-08-01

The high altitude of Jupiter's Great Red Spot (GRS) may enhance the upward flux of gaseous ammonia (NH3) into the high troposphere, where NH3 molecules can be photodissociated and initiate a chain of chemical reactions with downwelling acetylene molecules (C2H2). These reactions, experimentally studied earlier by (Ferris and Ishikawa [1987] Nature 326, 777-778) and (Ferris and Ishikawa [1988] J. Amer. Chem. Soc. 110, 4306-4312), produce chromophores that absorb in the visible and ultraviolet regions. In this work we photolyzed mixtures of NH3 and C2H2 using ultraviolet radiation with a wavelength of 214 nm and measured the spectral transmission of the deposited films in the visible region (400-740 nm). From these transmission data we estimated the imaginary indices of refraction. Assuming that ammonia grains at the top of the GRS clouds are coated with this material, we performed layered sphere and radiative transfer calculations to predict GRS reflection spectra. Comparison of those results with observed and previously unreported Cassini visible spectra and with true-color images of the GRS show that the unknown GRS chromophore is spectrally consistent with the coupled NH3-C2H2 photochemical products produced in our laboratory experiments. Using high-resolution mass spectrometry and infrared spectroscopy we infer that the chromophore-containing residue is composed of aliphatic azine, azo, and diazo compounds.

Chromophores from photolyzed ammonia reacting with acetylene: Application to Jupiters Great Red Spot

NASA Technical Reports Server (NTRS)

Carlson, Robert W.; Baines, Kevin H.; Anderson, M. S.; Filacchione, G.; Simon, A. A.

2016-01-01

The high altitude of Jupiter's Great Red Spot (GRS) may enhance the upward flux of gaseous ammonia (NH3 ) into the high troposphere, where NH3 molecules can be photodissociated and initiate a chain of chemical reactions with downwelling acetylene molecules (C2H2 ). These reactions, experimentally studied earlier by (Ferris and Ishikawa [1987] Nature 326, 777-778) and (Ferris and Ishikawa [1988] J. Amer. Chem. Soc. 110, 4306-4312), produce chromophores that absorb in the visible and ultraviolet regions. In this work we photolyzed mixtures of NH3 and C2H2 using ultraviolet radiation with a wavelength of 214 nm and measured the spectral transmission of the deposited films in the visible region (400-740 nm). From these transmission data we estimated the imaginary indices of refraction. Assuming that ammonia grains at the top of the GRS clouds are coated with this material, we performed layered sphere and radiative transfer calculations to predict GRS reflection spectra. Comparison of those results with observed and previously unreported Cassini visible spectra and with true-color images of the GRS show that the unknown GRS chromophore is spectrally consistent with the coupled NH3-C2H2 photochemical products produced in our laboratory experiments. Using high-resolution mass spectrometry and infrared spectroscopy we infer that the chromophore-containing residue is composed of aliphatic azine, azo, and diazo compounds.

Understanding nature's particle accelerators using high energy gamma-ray survey instruments

NASA Astrophysics Data System (ADS)

Abeysekara, Anushka Udara

Nature's particle accelerators, such as Pulsars, Pulsar Wind Nebulae, Active Galactic Nuclei and Supernova Remnants accelerate charged particles to very high energies that then produce high energy photons. The particle acceleration mechanisms and the high energy photon emission mechanisms are poorly understood phenomena. These mechanisms can be understood either by studying individual sources in detail or, alternatively, using the collective properties of a sample of sources. Recent development of GeV survey instruments, such as Fermi-LAT, and TeV survey instruments, such as Milagro, provides a large sample of high energy gamma-ray flux measurements from galactic and extra-galactic sources. In this thesis I provide constraints on GeV and TeV radiation mechanisms using the X-ray-TeV correlations and GeV-TeV correlations. My data sample was obtained from three targeted searches for extragalactic sources and two targeted search for galactic sources, using the existing Milagro sky maps. The first extragalactic candidate list consists of Fermi-LAT GeV extragalactic sources, and the second extragalactic candidate list consists of TeVCat extragalactic sources that have been detected by Imaging Atmospheric Cerenkov Telescopes (IACTs). In both extragalactic candidate lists Markarian 421 was the only source detected by Milagro. A comparison between the Markarian 421 time-averaged flux, measured by Milagro, and the flux measurements of transient states, measured by IACTs, is discussed. The third extragalactic candidate list is a list of potential TeV emitting BL Lac candidates that was synthesized using X-ray observations of BL Lac objects and a Synchrotron Self-Compton model. Milagro's sensitivity was not sufficient to detect any of those candidates. However, the 95% confidence flux upper limits of those sources were above the predicted flux. Therefore, these results provide evidence to conclude that the Synchrotron Self-Compton model for BL Lac objects is still a viable model. Targeted searches for galactic candidates were able to measure TeV emission associated with 14 Fermi-LAT GeV pulsars. In this thesis I also presented a new multi-wavelength technique that I developed to isolate the flux correlation factor (fΩ ) of pulsars as a function of pulsar spin down luminosity. The correlation between fΩ and pulsar spin-down luminosity for a Fermi-LAT GeV pulsar sample was measured using the measurements obtained in the Milagro targeted search performed for galactic sources and from the literature. The measured correlation has some features that favor the Outer Gap model over the Polar Cap, Slot Gap and One Pole Caustic models for pulsar emission in the energy range of 0.1 to 100 GeV. However, these simulated models failed to explain many other important pulsar population characteristics. Therefore, further improvements on the galactic pulsar population simulations are needed to provide tighter constraints.

The angular power spectrum measurement of the Galactic synchrotron emission using the TGSS survey

NASA Astrophysics Data System (ADS)

Choudhuri, Samir; Bharadwaj, Somnath; Ali, Sk. Saiyad; Roy, Nirupam; Intema, H. T.; Ghosh, Abhik

2018-05-01

Characterizing the diffuse Galactic synchrotron emission (DGSE) at arcminute angular scales is needed to remove this foregrounds in cosmological 21-cm measurements. Here, we present the angular power spectrum (Cl) measurement of the diffuse Galactic synchrotron emission using two fields observed by the TIFR GMRT Sky Survey (TGSS). We apply 2D Tapered Gridded Estimator (TGE) to estimate the Cl from the visibilities. We find that the residual data after subtracting the point sources is likely dominated by the diffuse Galactic synchrotron radiation across the angular multipole range 240 <= l <~ 500. We fit a power law to the measured Cl over this l range. We find that the slopes in both fields are consistent with earlier measurements. For the second field, however, we interpret the measured Cl as an upper limit for the DGSE as there is an indication of a significant residual point source contribution.

A complete X-ray sample of the high latitude sky from HEAO-1 A-2: log N lo S and luminosity functions

NASA Technical Reports Server (NTRS)

Piccinotti, G.; Mushotzky, R. F.; Boldt, E. A.; Holt, S. S.; Marshall, F. E.; Serlemitsos, P. J.; Shafer, R. A.

1981-01-01

An experiment was performed in which a complete X-ray survey of the 8.2 steradians of the sky at galactic latitudes where the absolute value of b is 20 deg down to a limiting sensitivity of 3.1 x ten to the minus 11th power ergs/sq cm sec in the 2-10 keV band. Of the 85 detected sources 17 were identified with galactic objects, 61 were identified with extragalactic objects, and 7 remain unidentified. The log N - log S relation for the non-galactic objects is well fit by the Euclidean relationship. The X-ray spectra of these objects were used to construct log N - log S in physical units. The complete sample of identified sources was used to construct X-ray luminosity functions, using the absolute maximum likelihood method, for clusters galaxies and active galactic nuclei.

The Galactic Distribution of Massive Star Formation from the Red MSX Source Survey

NASA Astrophysics Data System (ADS)

Figura, Charles C.; Urquhart, J. S.

2013-01-01

Massive stars inject enormous amounts of energy into their environments in the form of UV radiation and molecular outflows, creating HII regions and enriching local chemistry. These effects provide feedback mechanisms that aid in regulating star formation in the region, and may trigger the formation of subsequent generations of stars. Understanding the mechanics of massive star formation presents an important key to understanding this process and its role in shaping the dynamics of galactic structure. The Red MSX Source (RMS) survey is a multi-wavelength investigation of ~1200 massive young stellar objects (MYSO) and ultra-compact HII (UCHII) regions identified from a sample of colour-selected sources from the Midcourse Space Experiment (MSX) point source catalog and Two Micron All Sky Survey. We present a study of over 900 MYSO and UCHII regions investigated by the RMS survey. We review the methods used to determine distances, and investigate the radial galactocentric distribution of these sources in context with the observed structure of the galaxy. The distribution of MYSO and UCHII regions is found to be spatially correlated with the spiral arms and galactic bar. We examine the radial distribution of MYSOs and UCHII regions and find variations in the star formation rate between the inner and outer Galaxy and discuss the implications for star formation throughout the galactic disc.

Novae as a Class of Transient X-ray Sources

NASA Technical Reports Server (NTRS)

Mukai, K.; Orio, M.; Valle, M. Della

2007-01-01

Motivated by the recently discovered class of faint (10(exp 34)-10(exp 35) ergs/s) X-ray transients in the Galactic Center region, we investigate the 2-10 keV properties of classical and recurrent novae. Existing data are consistent with the idea that all classical novae are transient X-ray sources with durations of months to years and peak luminosities in the 10(exp 34)-10(exp 35)ergs/s range. This makes classical novae a viable candidate class for the faint Galactic Center transients. We estimate the rate of classical novae within a 15 arcmin radius region centered on the Galactic Center (roughly the field of view of XMM-Newton observations centered on Sgr A*) to be approx.0.1 per year. Therefore, it is plausible that some of the Galactic Center transients that have been announced to date are unrecognized classical novae. The continuing monitoring of the Galactic Center region carried out by Chandra and XMM-Newton may therefore provide a new method to detect classical novae in this crowded and obscured region, an

Very high-resolution observations of compact radio sources in the directions of supernova remnants

NASA Technical Reports Server (NTRS)

Geldzahler, B. J.; Shaffer, D. B.

1981-01-01

Compact radio sources whose positions lie within the outlines of supernova remnants may be the stellar remnants of supernova explosions and, if they are related to the supernova remnants, may be used to explore the nature of any morphological connection between the Galactic and extragalactic radio sources. Three such compact sources, G 127.11+0.54, CL 4, and 2051+433, have been observed at 10.65 GHz with an array of very long baseline interferometers having elements in the USA and West Germany. The radio source 2051+433 was also observed briefly at 5.01 GHz. The measured size of CL 4 at 10.65 GHz is about 0.0005 arcsec and seems to be dominated by the effects of interstellar scattering. No fringes were seen in 2051+433, and results indicate there is no compact component of 2051+433 smaller than 0.001 arcsec radiating at 10.65 GHz above a level of about 50 mJy. The possibility is presented that G 127.11+0.54 is a Galactic object. It is found to consist of two components separated by about 0.002 arcsec and oriented perpendicular to both the radio bridge of the supernova remnant G 127.1+0.5 and the underlying optical image. G 127.11+0.54, if Galactic, lies at the extreme low-luminosity end of an apparent continuum of Galactic and extragalactic compact radio source luminosities.

Evolution of Accretion Disc Geometry of GRS 1915+105 during its χ state as revealed by TCAF solution

NASA Astrophysics Data System (ADS)

Dutta, Broja G.; Pal, Partha Sarathi; Chakrabarti, Sandip K.

2018-06-01

The evolution of the C-type low frequency quasi-periodic oscillations (LFQPOs) and associated time lag in transient black hole sources as a function of time can be explained by variation of the Compton cloud size in a Two Component Advective Flow solution (TCAF). A similar study of a persistent source, GRS 1915+105, has not been attempted. We fit the evolution of QPOs with propagatory oscillating shock (POS) solution for two sets of so-called χ-state observations and find that the shock steadily recedes with almost constant velocity when QPO frequency is decreasing and the spectrum is hardening. The shock moves inward with a constant velocity v0 = 473.0 cm s-1 and v0 = 400.0 cm s-1 respectively in these two cases, when the QPO frequency is increasing and the spectrum softens. This behavior is similar to what was observed in XTE J1550-564 during the 1998 outburst. The time lag measured at the QPO frequency varies in a similar way as the size of the Compton cloud. Most interestingly, in both the cases, the lag switches sign (hard lag to soft lag) at a QPO frequency of ˜2.3 - 2.5 Hz irrespective of the energy of photons. We find, at very low frequencies <1 Hz, the Comptonizing Efficiency (CE) increases with QPO frequency and at higher QPO frequencies the trend is opposite. The time lags become mostly positive at all energies when CE is larger than ˜0.85% for both the sources.

The Einstein objective grating spectrometer survey of galactic binary X-ray sources

NASA Technical Reports Server (NTRS)

Vrtilek, S. D.; Mcclintock, J. E.; Seward, F. D.; Kahn, S. M.; Wargelin, B. J.

1991-01-01

The results of observations of 22 bright Galactic X-ray point sources are presented, and the most reliable measurements to date of X-ray column densities to these sources are derived. The results are consistent with the idea that some of the objects have a component of column density intrinsic to the source in addition to an interstellar component. The K-edge absorption due to oxygen is clearly detected in 10 of the sources and the Fe L and Ne K edges are detected in a few. The spectra probably reflect emission originating in a collisionally excited region combined with emission from a photoionized region excited directly by the central source.

Survey of the galactic disk from 1 = -150 deg to 1 = 82 deg in the submillimeter range

NASA Technical Reports Server (NTRS)

Caux, Emmanuel; Serra, Guy

1987-01-01

The first almost complete survey of the galactic disk from 1 = -150 deg to 1 = 82 deg in the submillimeter range (effective wavelength = 380 microns), performed with the AGLAE balloon-borne instrument modified to include a submillimeter channel, is reported. The instrumentation and observational procedures are described, as are the signal processing and calibration. The results are presented as a profile of the submillimeter brightness of the galactic disk displayed as a function of the galactic longitude. This profile exhibits diffuse emission all along the disk with bright peaks associated with resolved sources. The averaged galactic spectrum is in agreement with a temperature distribution of the interstellar cold dust.

Insights into the Galactic Cosmic-ray Source from the TIGER Experiment

NASA Technical Reports Server (NTRS)

Link, Jason T.; Barbier, L. M.; Binns, W. R.; Christian, E. R.; Cummings, J. R.; Geier, S.; Israel, M. H.; Lodders, K.; Mewaldt,R. A.; Mitchell, J. W.;

A 6.7 GHz Methanol Maser Survey at High Galactic Latitudes

NASA Astrophysics Data System (ADS)

Yang, Kai; Chen, Xi; Shen, Zhi-Qiang; Li, Xiao-Qiong; Wang, Jun-Zhi; Jiang, Dong-Rong; Li, Juan; Dong, Jian; Wu, Ya-Jun; Qiao, Hai-Hua; Ren, Zhiyuan

2017-09-01

We performed a systematic 6.7 GHz Class II methanol maser survey using the Shanghai Tianma Radio Telescope toward targets selected from the all-sky Wide-Field Infrared Survey Explorer (WISE) point catalog. In this paper, we report the results from the survey of those at high Galactic latitudes, I.e., | b| > 2°. Of 1473 selected WISE point sources at high latitude, 17 point positions that were actually associated with 12 sources were detected with maser emission, reflecting the rarity (1%-2%) of methanol masers in the region away from the Galactic plane. Out of the 12 sources, 3 are detected for the first time. The spectral energy distribution at infrared bands shows that these new detected masers occur in the massive star-forming regions. Compared to previous detections, the methanol maser changes significantly in both spectral profiles and flux densities. The infrared WISE images show that almost all of these masers are located in the positions of the bright WISE point sources. Compared to the methanol masers at the Galactic plane, these high-latitude methanol masers provide good tracers for investigating the physics and kinematics around massive young stellar objects, because they are believed to be less affected by the surrounding cluster environment.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zoghbi, Abderahmen; Miller, J. M.; King, A. L.

Disk and wind signatures are seen in the soft state of Galactic black holes, while the jet is seen in the hard state. Here we study the disk–wind connection in the ρ class of variability in GRS 1915+105 using a joint NuSTAR – Chandra observation. The source shows 50 s limit cycle oscillations. By including new information provided by the reflection spectrum and using phase-resolved spectroscopy, we find that the change in the inner disk inferred from the blackbody emission is not matched by reflection measurements. The latter is almost constant, independent of the continuum model. The two radii are comparablemore » only if the disk temperature color correction factor changes, an effect that could be due to the changing opacity of the disk caused by changes in metal abundances. The disk inclination is similar to that inferred from the jet axis, and oscillates by ∼10°. The simultaneous Chandra data show the presence of two wind components with velocities between 500 and 5000 km s{sup −1}, and possibly two more with velocities reaching 20,000 km s{sup −1} (∼0.06 c ). The column densities are ∼5 × 10{sup 22} cm{sup −2}. An upper limit to the wind response time of 2 s is measured, implying a launch radius of <6 × 10{sup 10} cm. The changes in wind velocity and absorbed flux require the geometry of the wind to change during the oscillations, constraining the wind to be launched from a distance of 290–1300 r{sub g} from the black hole. Both data sets support fundamental model predictions in which a bulge originates in the inner disk and moves outward as the instability progresses.« less

STUDIES OF THE ORIGIN OF HIGH-FREQUENCY QUASI-PERIODIC OSCILLATIONS OF MASS-ACCRETING BLACK HOLES IN X-RAY BINARIES WITH NEXT-GENERATION X-RAY TELESCOPES

DOE Office of Scientific and Technical Information (OSTI.GOV)

Beheshtipour, Banafsheh; Hoormann, Janie K.; Krawczynski, Henric, E-mail: b.beheshtipour@wustl.edu

Observations with RXTE ( Rossi X-ray Timing Explorer ) revealed the presence of high-frequency quasi-periodic oscillations (HFQPOs) of the X-ray flux from several accreting stellar-mass black holes. HFQPOs (and their counterparts at lower frequencies) may allow us to study general relativity in the regime of strong gravity. However, the observational evidence today does not yet allow us to distinguish between different HFQPO models. In this paper we use a general-relativistic ray-tracing code to investigate X-ray timing spectroscopy and polarization properties of HFQPOs in the orbiting Hotspot model. We study observational signatures for the particular case of the 166 Hz quasi-periodicmore » oscillation (QPO) in the galactic binary GRS 1915+105. We conclude with a discussion of the observability of spectral signatures with a timing-spectroscopy experiment such as the LOFT ( Large Observatory for X-ray Timing ) and polarization signatures with space-borne X-ray polarimeters such as IXPE ( Imaging X-ray Polarimetry Explorer ), PolSTAR ( Polarization Spectroscopic Telescope Array ), PRAXyS ( Polarimetry of Relativistic X-ray Sources ), or XIPE ( X-ray Imaging Polarimetry Explorer ). A mission with high count rate such as LOFT would make it possible to get a QPO phase for each photon, enabling the study of the QPO-phase-resolved spectral shape and the correlation between this and the flux level. Owing to the short periods of the HFQPOs, first-generation X-ray polarimeters would not be able to assign a QPO phase to each photon. The study of QPO-phase-resolved polarization energy spectra would thus require simultaneous observations with a first-generation X-ray polarimeter and a LOFT -type mission.« less

AGILE detection of prolonged gamma-ray emission from the Galactic Nova ASASSN-18fv

NASA Astrophysics Data System (ADS)

Piano, G.; Lucarelli, F.; Pittori, C.; Verrecchia, F.; Tavani, M.; Bulgarelli, A.; Parmiggiani, N.; Cardillo, M.; Ursi, A.; Minervini, G.; Donnarumma, I.; Vercellone, S.; Fioretti, V.; Pilia, M.; Gianotti, F.; Trifoglio, M.; Giuliani, A.; Mereghetti, S.; Caraveo, P.; Perotti, F.; Chen, A.; Argan, A.; Costa, E.; Del Monte, E.; Evangelista, Y.; Feroci, M.; Lazzarotto, F.; Lapshov, I.; Pacciani, L.; Soffitta, P.; Sabatini, S.; Vittorini, V.; Pucella, G.; Rapisarda, M.; Di Cocco, G.; Fuschino, F.; Galli, M.; Labanti, C.; Marisaldi, M.; Pellizzoni, A.; Trois, A.; Barbiellini, G.; Vallazza, E.; Longo, F.; Morselli, A.; Picozza, P.; Prest, M.; Lipari, P.; Zanello, D.; Cattaneo, P. W.; Rappoldi, A.; Ferrari, A.; Colafrancesco, S.; Paoletti, F.; Antonelli, A.; Giommi, P.; Salotti, L.; Valentini, G.; D'Amico, F.

2018-04-01

AGILE detected intense gamma-ray emission above 100 MeV from a source at Galactic coordinates (l, b) = (287.08, -1.08) +/- 0.6 deg (68% stat. c.l.) +/- 0.1 deg (syst.) (R.A., Dec. = 159.94, -59.84 deg, J2000), positionally consistent with the Galactic Nova ASASSN-18fv, previously reported in a gamma-ray flaring state by Fermi-LAT (ATel #11546).

ANA: Astrophysical Neutrino Anisotropy

NASA Astrophysics Data System (ADS)

Denton, Peter

2017-08-01

ANA calculates the likelihood function for a model comprised of two components to the astrophysical neutrino flux detected by IceCube. The first component is extragalactic. Since point sources have not been found and there is increasing evidence that one source catalog cannot describe the entire data set, ANA models the extragalactic flux as isotropic. The second component is galactic. A variety of catalogs of interest are also provided. ANA takes the galactic contribution to be proportional to the matter density of the universe. The likelihood function has one free parameter fgal that is the fraction of the astrophysical flux that is galactic. ANA finds the best fit value of fgal and scans over 0

Gravitational lensing of active galactic nuclei.

PubMed

Hewitt, J N

1995-12-05

Most of the known cases of strong gravitational lensing involve multiple imaging of an active galactic nucleus. The properties of lensed active galactic nuclei make them promising systems for astrophysical applications of gravitational lensing; in particular, they show structure on scales of milliseconds of arc to tens of seconds of arc, they are variable, and they are polarized. More than 20 cases of strong gravitational lenses are now known, and about half of them are radio sources. High-resolution radio imaging is making possible the development of well-constrained lens models. Variability studies at radio and optical wavelengths are beginning to yield results of astrophysical interest, such as an independent measure of the distance scale and limits on source sizes.

Gamma-ray burst constraints on the galactic frequency of extra-solar Oort clouds

NASA Technical Reports Server (NTRS)

Shull, J. Michael; Stern, S. Alan

1994-01-01

With the strong CGRO/BATSE evidence that most gamma-ray bursts do not come from galactic neutron stars, models involving the accretion of a comet onto a neutron star (NS) no longer appear to be strong contenders for explaining the majority of bursts. If this is the case, then it is worth asking whether the lack of an observed galactic gamma-ray burst population provides a useful constraint on the number of comets and comet clouds in the galaxy. Owing to the previously unrecognized structural weakness of cometary nuclei, we find the capture cross sections for comet-NS events to be much higher than previously published estimates, with tidal breakup at distances R(sub b) approximately equals to 4 x 10(exp 10) cm from the NS. As a result, impacts of comets onto field NS's penetrating the Oort Clouds of other stars are found to dominate all other galactic NS-comet capture rates by a factor of 100. This in turn predicts that if comet clouds are common, there should be a significant population of repeater sources with (1) a galactic distribution, (2) space-correlated repetition, and (3) a wide range of peak luminosities and luminosity time histories. If all main sequences stars have Oort Clouds like our own, we predict approximately 4000 such repeater sources in the Milky Way at any time, each repeating on timescales of months to years. Based on estimates of the sensitivity of the CGRO/BATSE instrument and assuming isotropic gamma-ray beaming from such events, we estimate that a population of approximately 20-200 of these galactic NS-Oort Cloud gamma-ray repeater sources should be detectable by CGRO. In addition, if giant planet formation is common in the galaxy, we estimate that the accretion of isolated comets injected to the interstellar medium by giant planet formation should produce an additional source of galactic, nonrepeating events. Comparing these estimates to the three to four soft gamma-ray repeater sources detected by BATSE, one is forced to conclude that (1) comet impacts on NS's are inefficient at producing gamma-rays; or (2) the gamma-rays from such events are highly beamed; or (3) the fraction of stars in the galaxy with Oort Cloud like our own is not higher than a few percent.

BLAST: The Balloon-Borne Large Aperture Submillimeter Telescope

NASA Technical Reports Server (NTRS)

Devlin, Mark; Ade, Peter; Bock, Jamie; Dicker, Simon; Griffin, Matt; Gunderson, Josh; Halpern, Mark; Hargrave, Peter; Hughes, David; Klein, Jeff

2004-01-01

BLAST is the Balloon-borne Large-Aperture Sub-millimeter Telescope. It will fly from a Long Duration Balloon (LDB) platform from Antarctica. The telescope design incorporates a 2 m primary mirror with large-format bolometer arrays operating at 250, 350 and 500 microns. By providing the first sensitive large-area (10 sq. deg.) sub-mm surveys at these wavelengths, BLAST will address some of the most important galactic and cosmological questions regarding the formation and evolution of stars, galaxies and clusters. Galactic and extragalactic BLAST surveys will: (1) identify large numbers of high-redshift galaxies; (2) measure photometric redshifts, rest-frame FIR luminosities and star formation rates thereby constraining the evolutionary history of the galaxies that produce the FIR and sub-mm background; (3) measure cold pre-stellar sources associated with the earliest stages of star and planet formation; (4) make high-resolution maps of diffuse galactic emission over a wide range of galactic latitudes. In addition to achieving the above scientific goals, the exciting legacy of the BLAST LDB experiment will be a catalogue of 3000-5000 extragalactic sub-mm sources and a 100 sq. deg. sub-mm galactic plane survey. Multi-frequency follow-up observations from SIRTF, ASTRO-F, and Herschel, together with spectroscopic observations and sub-arcsecond imaging from ALMA are essential to understand the physical nature of the BLAST sources.

The Galactic Magnetic Field and its lensing of Ultrahigh Energy and Galactic Cosmic Rays

NASA Astrophysics Data System (ADS)

Farrar, Glennys

2015-08-01

It has long been recognized that magnetic fields play an important role in many astrophysical environments, but the magnetic field strength and structure has only been quantitatively determined for relatively few systems beyond our solar system.Our understanding of the Galactic magnetic field (GMF) has improved tremendously in recent years. The Jansson-Farrar (2012) (JF12) GMF model is the most realistic and comprehensive model available. It was constrained by fitting all-sky Faraday Rotation Measures of ~40k extragalactic sources, simultaneously with WMAP polarized (Q,U) and total synchrotron emission maps - together providing a total of more than 10,000 independent datapoints, each with measured astrophysical variance. In addition to disk and toroidal halo components, a previously overlooked coherent poloidal halo field proves to be necessary to account for the RM, Q and U data. Moreover a “striated” random component is needed in addition to a fully random component, in both disk and halo.The talk will give a concise review of the JF12 model and its derivation, with emphasis on which features of the GMF are well or poorly established. I will show that the data unambiguously demand a large scale coherent component to the halo field which is a diverging-spiral centered on the Galactic center, with field lines running from Southern to Northern hemispheres. The puzzles posed by the large scale coherent halo and disk magnetic fields, and their possible origins, will be discussed.Having a good model of the Galactic magnetic field is crucial for determining the sources of UHECRs, for modeling the transport of Galactic CRs (the halo field provides a heretofore-overlooked escape route for by diffusion along its field lines), and for calculating the background to dark matter and CMB-cosmology studies. I will present new results on the lensing effect of the GMF on UHECRs, which produces multiple images and dramatic magnification and demagnification that varies with source direction and CR rigidity, E/Z, and show movies of VHECR propagation from a transient source at the Galactic Center or elsewhere in the Galaxy.

The gamma ray continuum spectrum from the galactic center disk and point sources

NASA Technical Reports Server (NTRS)

Gehrels, Neil; Tueller, Jack

1992-01-01

A light curve of gamma-ray continuum emission from point sources in the galactic center region is generated from balloon and satellite observations made over the past 25 years. The emphasis is on the wide field-of-view instruments which measure the combined flux from all sources within approximately 20 degrees of the center. These data have not been previously used for point-source analyses because of the unknown contribution from diffuse disk emission. In this study, the galactic disk component is estimated from observations made by the Gamma Ray Imaging Spectrometer (GRIS) instrument in Oct. 1988. Surprisingly, there are several times during the past 25 years when all gamma-ray sources (at 100 keV) within about 20 degrees of the galactic center are turned off or are in low emission states. This implies that the sources are all variable and few in number. The continuum gamma-ray emission below approximately 150 keV from the black hole candidate 1E1740.7-2942 is seen to turn off in May 1989 on a time scale of less than two weeks, significantly shorter than ever seen before. With the continuum below 150 keV turned off, the spectral shape derived from the HEXAGONE observation on 22 May 1989 is very peculiar with a peak near 200 keV. This source was probably in its normal state for more than half of all observations since the mid-1960's. There are only two observations (in 1977 and 1979) for which the sum flux from the point sources in the region significantly exceeds that from 1E1740.7-2942 in its normal state.

Galactic Bulge Giants: Probing Stellar and Galactic Evolution. 1. Catalogue of Spitzer IRAC and MIPS Sources (PREPRINT)

DTIC Science & Technology

2010-12-29

1997), the 2 Micron All Sky Survey ( 2MASS ; Skrutskie et al. 2006), the Midcourse Space Experiment (MSX) catalogue, and the Infra- Red Astronomical...made for these sources with a search radius of 3.′′0 with DENIS and 2MASS , and 30.′′0 for identification with an MSX or IRAS counterpart. The... 2MASS and DENIS counterpart (depending on the field, between 3.1% and 6.7% of the sources), or (ii) a DENIS and 2MASS counterpart at a distance

Chandra X-Ray Observations of the Two Brightest Unidentified High Galactic Latitude Fermi-LAT Gamma-Ray Sources

NASA Technical Reports Server (NTRS)

Cheung, C. C.; Donato, D.; Gehrels, N.; Sokolovsky, K. V.; Giroletti, M.

2012-01-01

We present Chandra ACIS-I X-ray observations of 0FGL J1311.9-3419 and 0FGL J1653.4-0200, the two brightest high Galactic latitude (absolute value (beta) >10 deg) gamma-ray sources from the three-month Fermi Large Area Telescope (LAT) bright source list that are still unidentified. Both were also detected previously by EGRET, and despite dedicated multi-wavelength follow-up, they are still not associated with established classes of gamma-ray emitters like pulsars or radio-loud active galactic nuclei. X-ray sources found in the ACIS-I fields of view are cataloged, and their basic properties are determined. These are discussed as candidate counterparts to 0FGL J1311.9-3419 and 0FGL J1653.4-0200, with particular emphasis on the brightest of the 9 and 13 Chandra sources detected within the respective Fermi-LAT 95% confidence regions. Further follow-up studies, including optical photometric and spectroscopic observations, are necessary to identify these X-ray candidate counterparts in order to ultimately reveal the nature of these enigmatic gamma-ray objects.

VizieR Online Data Catalog: MSX high-contrast IRDCs with NH3 (Chira+,

NASA Astrophysics Data System (ADS)

Chira, R.-A.; Beuther, H.; Linz, H.; Walmsley, C. M.; Menten, K. M.; Bonfman, L.

2013-02-01

Based on MSX data, a catalogue of more than 10,000 candidate IRDCs was compiled. From this catalogue we selected a complete sample of northern hemisphere high-contrast IRDCs with Galactic longitudes >=19.27° (and nine exceptions with Galactic longitudes <19°). The sample was observed in ammonia (1,1) and (2,2) inversion transitions with the Effelsberg 100-m telescope. NH3 parameters are derived for 109 sample sources. For each source galactic coordinates, brightness temperatures, line width FWHMs and optical depths of (1,1) and (2,2) inversion lines and LSR velocity of (1,1) inversion line are given. Furthermore, we derived the rotation and kinetic temperatures, ammonia column densities, kinematic distances and virial masses using the NH3 data. In addition, notes about whether the sources being associated with Spitzer sources or not are given. Using ATLASGAL data, the 870 micron flux densities gas masses, virial parameters, H2 column densities and NH3 abundances are given. In addition, we listed the sample sources where no ammonia which did not fulfil our selection criteria. (4 data files).

DOE Office of Scientific and Technical Information (OSTI.GOV)

Crowder, Jeff; Jet Propulsion Laboratory, California Institute of Technology, Pasadena, California 91109; Cornish, Neil J.

Low frequency gravitational wave detectors, such as the Laser Interferometer Space Antenna (LISA), will have to contend with large foregrounds produced by millions of compact galactic binaries in our galaxy. While these galactic signals are interesting in their own right, the unresolved component can obscure other sources. The science yield for the LISA mission can be improved if the brighter and more isolated foreground sources can be identified and regressed from the data. Since the signals overlap with one another, we are faced with a 'cocktail party' problem of picking out individual conversations in a crowded room. Here we presentmore » and implement an end-to-end solution to the galactic foreground problem that is able to resolve tens of thousands of sources from across the LISA band. Our algorithm employs a variant of the Markov chain Monte Carlo (MCMC) method, which we call the blocked annealed Metropolis-Hastings (BAM) algorithm. Following a description of the algorithm and its implementation, we give several examples ranging from searches for a single source to searches for hundreds of overlapping sources. Our examples include data sets from the first round of mock LISA data challenges.« less

X-Ray Spectral Analysis of the Steady States of GRS1915+105

NASA Astrophysics Data System (ADS)

Peris, Charith S.; Remillard, Ronald A.; Steiner, James F.; Vrtilek, Saeqa D.; Varnière, Peggy; Rodriguez, Jerome; Pooley, Guy

2016-05-01

We report on the X-ray spectral behavior within the steady states of GRS1915+105. Our work is based on the full data set of the source obtained using the Proportional Counter Array (PCA) on the Rossi X-ray Timing Explorer (RXTE) and 15 GHz radio data obtained using the Ryle Telescope. The steady observations within the X-ray data set naturally separated into two regions in the color-color diagram and we refer to these regions as steady-soft and steady-hard. GRS1915+105 displays significant curvature in the coronal component in both the soft and hard data within the RXTE/PCA bandpass. A majority of the steady-soft observations displays a roughly constant inner disk radius ({R}{{in}}), while the steady-hard observations display an evolving disk truncation which is correlated to the mass accretion rate through the disk. The disk flux and coronal flux are strongly correlated in steady-hard observations and very weakly correlated in the steady-soft observations. Within the steady-hard observations, we observe two particular circumstances when there are correlations between the coronal X-ray flux and the radio flux with log slopes η ˜ 0.68+/- 0.35 and η ˜ 1.12+/- 0.13. They are consistent with the upper and lower tracks of Gallo et al. (2012), respectively. A comparison of the model parameters to the state definitions shows that almost all of the steady-soft observations match the criteria of either a thermal or steep power-law state, while a large portion of the steady-hard observations match the hard-state criteria when the disk fraction constraint is neglected.

Astronomers Go Behind The Milky Way To Solve X-Ray Mystery

NASA Astrophysics Data System (ADS)

2001-08-01

Through layers of gas and dust that stretch for more than 30,000 light years, astronomers using NASA's Chandra X-ray Observatory have taken a long, hard look at the plane of the Milky Way galaxy and found that its X-ray glow comes from hot and diffuse gas. The findings, published in the August 10 issue of Science, help to settle a long-standing mystery about the source of the X-ray emission from the galactic plane. Scientists have debated whether the Milky Way plane's X-ray emission was diffuse light or from individual stars. Armed with Chandra, an international team led Dr. Ken Ebisawa of NASA's Goddard Space Flight Center, Greenbelt, MD zoomed in on a tiny region of the galactic plane in the constellation Scutum. "The point sources we saw in the galactic plane were actually active galaxies with bright cores millions of light years behind our galaxy," said Ebisawa. "The number of these sources is consistent with the expected number of extragalactic sources in the background sky. We saw few additional point sources within our Galaxy." The observation marks the deepest X-ray look at the so-called "zone of avoidance" -- a region of space behind which no optical observation has ever been taken because thick dust and gas in the spiral arms of the Milky Way galaxy block out visible radiation. Infrared, radio, and X-rays, however, can penetrate this dust and gas. Detection of diffuse X rays emanating from the Galactic plane, what we call the "Milky Way" in visible light, indicates the presence of plasma gas with temperatures of tens of millions of degrees Celsius. Smoothed X-ray Image of the Galactic Plane Smoothed X-ray Image of the Galactic Plane Gas this hot would escape the gravitational confines of the Milky Way galaxy under normal circumstances. The fact that it still lingers within the Galactic plane is the next mystery to solve. One possibility, suggested by Ebisawa is that hot plasma may be confined to the Milky Way by magnetic fields. The Chandra observation, conducted in February 2000, lasted 28 hours. The team observed what was known to be a "blank" region of the galactic plane where the Japanese X-ray satellite ASCA had previously observed but found no individual X-ray sources. The team also discovered 36 bright distant galaxies lurking in the background of this section of the galactic plane, while the foreground was devoid of stars or other individual objects emitting X-rays. Chandra, and now the European XMM-Newton satellite, are at long last beginning to collect light from behind our galaxy. X-radiation from the 36 newly discovered galaxies passes through the Milky Way on its journey towards Earth. This light, therefore, carries the imprint of all that it passes through and will allow astronomers to measure the distribution and physical condition of matter in our Galaxy. Participating in the Chandra observation and Science article are Yoshitomo Maeda of Pennsylvania State University; Hidehiro Kaneda of the Institute of Space and Astronautical Science in Japan; and Shigeo Yamauchi of Iwate University in Japan. Chandra observed the galactic plane with its Advanced CCD Imaging Spectrometer (ACIS) instrument, which was developed for NASA by Pennsylvania State University, University Park, and Massachusetts Institute of Technology, Cambridge. NASA's Marshall Space Flight Center in Huntsville, AL, manages the Chandra program, and TRW, Inc., Redondo Beach, CA, is the prime contractor for the spacecraft. The Smithsonian's Chandra X-ray Center controls science and flight operations from Cambridge, MA.

Assessment of the value of a genetic risk score in improving the estimation of coronary risk

USDA-ARS?s Scientific Manuscript database

The American Heart Association has established criteria for the evaluation of novel markers of cardiovascular risk. In accordance with these criteria, we assessed the association between a multi-locus genetic risk score (GRS) and incident coronary heart disease (CHD), and evaluated whether this GRS ...

Student Graduation in Spain: To What Extent Does University Expenditure Matter?

ERIC Educational Resources Information Center

García-Estevez, Javier; Duch-Brown, Néstor

2014-01-01

Graduation rates (GRs) remain one of the most frequently applied measures of institutional performance. This paper analyzes the relationship between university characteristics and GRs in Spain, using a dataset for the entire public university system over the period 1998-2008. Since we observe the same university over several years, we address the…

Genetic risk of progression to type 2 diabetes and response to intensive lifestyle or metformin in prediabetic women with and without a history of gestational diabetes mellitus.

PubMed

Sullivan, Shannon D; Jablonski, Kathleen A; Florez, Jose C; Dabelea, Dana; Franks, Paul W; Dagogo-Jack, Sam; Kim, Catherine; Knowler, William C; Christophi, Costas A; Ratner, Robert

2014-04-01

OBJECTIVE The Diabetes Prevention Program (DPP) trial investigated rates of progression to diabetes among adults with prediabetes randomized to treatment with placebo, metformin, or intensive lifestyle intervention. Among women in the DPP, diabetes risk reduction with metformin was greater in women with prior gestational diabetes mellitus (GDM) compared with women without GDM but with one or more previous live births. RESEARCH DESIGN AND METHODS We asked if genetic variability could account for these differences by comparing β-cell function and genetic risk scores (GRS), calculated from 34 diabetes-associated loci, between women with and without histories of GDM. RESULTS β-Cell function was reduced in women with GDM. The GRS was positively associated with a history of GDM; however, the GRS did not predict progression to diabetes or modulate response to intervention. CONCLUSIONS These data suggest that a diabetes-associated GRS is associated with development of GDM and may characterize women at risk for development of diabetes due to β-cell dysfunction.

Longitudinal course of eating disorders after transsexual treatment: a report of two cases.

PubMed

Hiraide, Maiko; Harashima, Saki; Yoneda, Ryo; Otani, Makoto; Kayano, Mami; Yoshiuchi, Kazuhiro

2017-01-01

Several reports have been published on patients with gender dysphoria and eating disorders. However, there have been few reports on the longitudinal course of eating disorders after gender reassignment surgery (GRS)/gender confirmation surgery (GCS). We report two Japanese cases of transsexual persons with eating disorders who underwent GRS/GCS, one male-to-female (MtF) and one female-to-male (FtM). Case 1 was a 35-year MtF person who had a 14-year-course of bulimia nervosa that developed after GRS. Case 2 was a 35-year FtM person with anorexia nervosa who underwent GCS 9 years before. We found that the treatment of our transsexual patients influenced the course of their eating disorders for a long period, which could be attributable partly to the cultural situation in Japan, an East Asian country. It is possible that many gender identity problems and identity problems in general persist even after surgery and treatment; therefore, continual clinical support should be provided for patients with gender dysphoria and eating disorders even after hormonal therapy or GRS/GCS.

A Very Massive Stellar Black Hole in the Milky Way Galaxy

NASA Astrophysics Data System (ADS)

2001-11-01

VLT ISAAC Uncovers an Enigmatic Microquasar Summary One of the most enigmatic stellar systems in our Milky Way Galaxy has been shown to harbour a very massive black hole. With 14 times more mass than the Sun [1], this is the heaviest known stellar black hole in the Galaxy. Using the ISAAC instrument on the VLT 8.2-m ANTU telescope at the ESO Paranal Observatory , an international team of astronomers [2] peered into a remote area of the Milky Way to probe the binary system GRS 1915+105 , located almost 40,000 light-years away. They were able to identify the low-mass star that feeds the black hole by means of a steady flow of stellar material. A detailed follow-up study revealed how this star revolves around its hungry companion. The analysis of the orbital motion then made it possible to estimate the mass of the black hole. The observation of the heavy black hole in GRS 1915+105 is opening up fundamental questions about how massive stellar black holes form, and whether or not such objects rotate around their own axes. PR Photo 31a/01 : Schematic drawing of the GRS 1915+105 binary system . PR Photo 31b/01 : ISAAC spectrum of the companion star . PR Photo 31c/01 : The velocity curve from which the mass of the black hole was derived . Miniature Quasars in our Galaxy ESO PR Photo 31a/01 ESO PR Photo 31a/01 [Preview - JPEG: 400 x 399 pix - 44k] [Normal - JPEG: 800 x 797 pix - 192k] Caption : PR Photo 31a/01 shows an artist's impression of the binary stellar system GRS 1915+105 in which a heavy black hole is present. The distance between the donor star and the accreting black hole is about half the distance between the Earth and the Sun. The drawing illustrates how the donor star feeds the black hole via an accretion disk , and also the emergence of jets perpendicular to the disk. In the lower panel the blue colour denotes matter that spirals in the accretion disk, while in the orange region matter is freely falling radially into the black hole. Technical information about this photo is available below. A few objects within our own Galaxy look very much like miniature versions of the very energetic quasars , observed at the centres of remote galaxies. Quasars are believed to harbour supermassive black holes at their centres, and they emit copious amounts of energy as the surrounding matter accretes into a disk and spirals into the hole. Occasionally, quasars spout jets of gas at velocities very close to the speed of light. Microquasars are basically the same thing, but at scales a million times smaller. They are binary stellar systems in our Galaxy in which a more or less normal star orbits a compact object, which may be a neutron star or a black hole. Those microquasars also show energetic outflows and signs of accretion of matter onto the compact object. Not unexpectedly, it appears that the most enigmatic of these systems are the ones that contain a black hole. The discovery of objects that are relatively nearby in cosmological terms and which mimic the properties of the remote quasars has opened up interesting new perspectives and promises to help us to better understand the strange phenomena that are associated with jets and accretion disks around black holes. GRS 1915+105 - A unique galactic laboratory The binary stellar system GRS 1915+105 is one of a handful of microquasars known in our Galaxy. This system was first discovered in 1994 by the GRANAT X-ray satellite. In X-ray radiation, GRS 1915+105 shows bright and sporadic outbursts. The variable X-ray radiation has been interpreted as due to infall of matter onto the black hole from the inner region of a surrounding accretion disk. This enigmatic source was also observed to eject clouds of hot gas at velocities very close to the speed of light. GRS 1915+105 is thus a prototype microquasar and has become a main target for the study of accretion onto a black hole of stellar mass. GRS 1915+105 lies in the constellation Aquila (The Eagle) and is located near the main plane of the Milky Way Galaxy, some 40 000 light-years away from the Sun. A lot of gas and dust in that plane hides it from our view in the visible light. This obscuration has severely impeded any detailed investigation of the system, and it still remained to be proven whether or not it really contains a massive black hole. Identification of the binary companion ESO PR Photo 31b/01 ESO PR Photo 31b/01 [Preview - JPEG: 400 x 262 pix - 45k] [Normal - JPEG: 800 x 523 pix - 128k] Caption : PR Photo 31b/01 shows one of the infrared ISAAC spectra of GRS 1915+105 . It is a K-band spectrum (in the 2.2 µm near-infrared spectral region) that reveals several previously unnoticed spectral features from the companion star that donates matter to the black hole. The presence and characteristics of these lines indicate that this donor star is a low-mass star. Observing how the positions of the strong carbon monoxide bands (CO) shift with time has allowed the astronomers to measure the orbital motion of the donor star, cf. Photo 31c/01 . Technical information about this photo is available below. The team of astronomers [2] therefore decided to perform infrared observations of GRS 1915+105 , in a spectral region where the obscuration of dust is much less severe than in visible light. It is still not a trivial observation since even in the infrared only a few percent of the light emitted by GRS 1915+105 reaches Earth after the long journey through the intervening clouds. A large telescope is needed to register detailed spectra of GRS 1915+105 . The first set of observations was obtained with the multi-mode ISAAC instrument on the VLT 8.2-m ANTU telescope , already in the summer of 1999. The spectra were of very high quality and contained several spectral lines ( PR Photo 31b/01 ). In particular, a number of previously unnoticed spectral features from carbon monoxide molecules were securely identified. These lines are formed in the atmosphere of the star which revolves around the black hole and feeds it with matter (it is therefore known as the "donor star"). A high-quality infrared spectrum was needed to detect and measure these lines because only a small fraction of the light received actually comes from the binary star. Most of the light that is registered by the instrument comes from the surrounding accretion disk or from ejected matter in the neighbourhood, and therefore tends to hide the spectral lines of the donor star. After a careful analysis of the observed spectral lines, the astronomers were able to infer that the star donating matter to the compact object is a low-mass star , with about the same mass as our Sun. But this was only the beginning of this long-term observational programme. Seeing the motion ESO PR Photo 31c/01 ESO PR Photo 31c/01 [Preview - JPEG: 400 x 332 pix - 39k] [Normal - JPEG: 800 x 664 pix - 112k] Caption : PR Photo 31c/01 displays the velocity of the donor star, as determined from the Doppler shifts of the carbon monoxide lines ( PR Photo 31b/01 ). It shows velocities from sixteen observations taken with VLT ANTU/ISAAC between April and September 2000. A periodogram analysis (upper panel) determines the period as 33.5 days and an orbit with this period represents the best fit to the data (lower panel). The orbital velocity of the binary star moving around the black hole is about 140 km/s. The identification of the distinct carbon monoxide bands in the spectrum of the donor star then allowed the astronomers to search for the orbital motion of the system. As the binary star orbits its compact and dark companion, the Doppler motion will induce small shifts in the positions of the spectral lines. Monitoring these shifts reveals how fast the star moves and therefore determines the size and shape of its orbit around the black hole. This in turn makes it possible to determine the mass of the invisible object that is needed to keep the star moving in that orbit. The observational campaign started in April 2000 and continued until September 2000 with observations taken on 16 different nights. The velocity variations revealed by the line shifts were searched for periodicity and the best fit was found for a period of 33.5 days . This is interpreted as the time it takes for the donor star to orbit the compact object. The radial velocity curve for this period is shown in Photo 31c/01 . From the orbital motion, it is then easy to deduce a lower limit on the mass of the compact object. In this way, it was shown that the invisible companion in GRS 1915+105 must in any case be heavier than 9.5 solar masses. The nature of the compact object A compact, unseen companion can either be a neutron star or a black hole. It is quite difficult to distinguish between these two invisible candidates. However, it is known that a neutron star cannot possibly be heavier than about 3 solar masses. If a neutron star were heavier than that, it would no longer be able to support its own weight and would quickly collapse into a black hole. The lower limit on the mass determined for GRS 1915+105 is definitely higher than the maximum possible mass for a neutron star. The conclusion is clear: the compact object in GRS 1915+105 is indeed a black hole . However, the astronomers could do better than this - they were able to deduce not just a minimum, but also the actual mass of the black hole . First, knowing the nature of the donor star gives a good estimate of the mass of that star. Secondly, some constraints can be set on the inclination of the orbit from the known jet features. With this additional information, the astronomers finally concluded that the black hole must weigh as much as 14 solar masses . Until now, about a dozen black holes in the Galaxy have been confirmed by determining their masses in this way. GRS 1915+105 is the heaviest of the stellar black holes so far known in the Milky Way Galaxy . Implications and puzzles Knowing the mass of the black hole in GRS 1915+105 now poses challenges to several fields in astrophysics. First of all, it is not easy to understand how such a massive black hole can be formed in a binary stellar system. It is well known that the most massive stars lose significant fractions of their mass through violent stellar winds at the end of their lives. Interaction among the two stars in a binary system can further increase the mass loss by the massive star. It thus remains to be investigated how any star can retain enough mass to eventually end up forming a black hole as heavy as 14 solar masses. Another puzzling aspect regards the spin of the black hole . That some stellar black holes rotate has been suggested on several grounds. It is believed that when the black hole rotates in the same direction as does the accretion disk, the disk can extend much closer inwards towards the black hole. The result is a hotter disk. Two X-ray binaries are known to be very hot, GRS 1915+105 and Nova Scorpii, and it was therefore believed that these two contain black holes that must spin rapidly. A completely different line of evidence for black hole rotation comes from the quasi-periodic oscillations often seen in X-ray binaries. Those oscillations are generally interpreted as due to effects of the spinning black hole on the surrounding accretion disk, although the exact mechanism is a matter of debate. However, the new mass determination for the black hole in GRS 1915+105 indicates that the picture may not be as simple as that. In fact, if GRS 1915+105 and Nova Scorpii both have rapidly spinning black holes, none of the current theories for the quasi-periodic oscillations seem to work. And so, as is often the case in science, new information also brings new puzzles. More Information The research described in this Press Release will appear in "GRS 1915+105 - An unusually massive stellar black hole in the Galaxy" by Jochen Greiner , Mark McCaughrean and Jean-Gabriel Cuby in the November 29, 2001, issue of the science journal "Nature". The first stage is described in "Identification of the donor in the X-ray binary GRS 1915+105" by Greiner and co-authors and is published in the July 2001 issue of the European research journal "Astronomy and Astrophysics". Note [1]: 1 solar mass = 2 10 30 kg. The mass of the black hole in the X-ray binary stellar system GRS 1915+105 described in this Press Release is therefore nearly 30,000,000,000,000,000,000,000,000,000,000 kg. [2]: The team consists of Jochen Greiner , Mark McCaughrean (Astrophysical Institute Potsdam, Germany) and Jean-Gabriel Cuby (European Southern Observatory, Chile). Technical information about the photos Robert Hynes (University of Southampton, UK) provided software to produce the upper part of Photo 31a/01 . Photo 31b/01 with a K-band spectrum of GRS 1915+105 was obtained with ISAAC on the 8.2-m VLT ANTU telescope at Paranal. It is a sum of five spectra where each exposure is made up of eight integrations of 250 seconds each. The total exposure time is thus 167 minutes. With a one arc second slit, the spectral resolution is about 3000.

Number density distribution of near-infrared sources on a sub-degree scale in the Galactic center: Comparison with the Fe XXV Kα line at 6.7 keV

NASA Astrophysics Data System (ADS)

Yasui, Kazuki; Nishiyama, Shogo; Yoshikawa, Tatsuhito; Nagatomo, Schun; Uchiyama, Hideki; Tsuru, Takeshi Go; Koyama, Katsuji; Tamura, Motohide; Kwon, Jungmi; Sugitani, Koji; Schödel, Rainer; Nagata, Tetsuya

2015-12-01

The stellar distribution derived from an H- and KS-band survey of the central region of our Galaxy is compared with the Fe XXV Kα (6.7 keV) line intensity observed with the Suzaku satellite. The survey is for the galactic coordinates |l| ≲ 3.0° and |b | ≲ 1.0° (equivalent to 0.8 kpc × 0.3 kpc for R⊙ = 8 kpc), and the number-density distribution N(KS,0; l, b) of stars is derived by using the extinction-corrected magnitude KS,0 = 10.5. This is deep enough to probe the old red-giant population and in turn to estimate the (l, b) distribution of faint X-ray point sources such as coronally active binaries and cataclysmic variables. In the Galactic plane (b = 0°), N(10.5; l, b) increases in the direction of the Galactic center as |l|-0.30±0.03 in the range of - 0.1° ≥ l ≥ - 0.7°, but this increase is significantly slower than the increase (|l|-0.44±0.02) of the Fe XXV Kα line intensity. If normalized with the ratios in the outer region 1.5° ≤ |l| ≤ 2.8°, where faint X-ray point sources are argued to dominate the diffuse Galactic X-ray ridge emission, the excess of the Fe XXV Kα line intensity over the stellar number density is at least a factor of two at |l| = 0.1°. This indicates that a significant part of the Galactic-center diffuse emission arises from a truly diffuse optically thin thermal plasma, and not from an unresolved collection of faint X-ray point sources related to the old stellar population.

Thermoelastic properties of grossular–andradite solid solution at high pressures and temperatures

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fan, Dawei; Kuang, Yunqian; Xu, Jingui

2016-09-21

The pressure–volume–temperature (P–V–T) equation of state (EoS) of synthetic grossular (Grs)–andradite (And) solid-solution garnet sample have been measured at high temperature up to 900 K and high pressures up to 22.75 GPa for Grs50And50, by using in situ angle-dispersive X-ray diffraction and diamond anvil cell. Analysis of room-temperature P–V data to a third-order Birch–Murnaghan (BM) EoS yields: V0 = 1706.8 ± 0.2 Å3, K0 = 164 ± 2 GPa and K'0 = 4.7 ± 0.5. Fitting of our P–V–T data by means of the high-temperature third-order BM EoS gives the thermoelastic parameters: V0 = 1706.9 ± 0.2 Å3, K0 =more » 164 ± 2 GPa, K'0 = 4.7 ± 0.2, (∂K/∂T)P = -0.018 ± 0.002 GPa K-1, and α0 = (2.94 ± 0.07) × 10-5 K-1. The results also confirm that grossular content increases the bulk modulus of the Grs-And join following a nearly ideal mixing model. The relation between bulk modulus and Grs mole fraction (XGrs) in this garnet join is derived to be K0 (GPa) = (163.7 ± 0.7) + (0.14 ± 0.02) XGrs (R2 = 0.985). Present results are also compared to previously studies determined the thermoelastic properties of Grs-And garnets.« less

Diagnosis of myocardial infarction using the new universal definition: is it enough for risk stratification and guiding decision for revascularization?

PubMed

Calé, Rita; Ferreira, Jorge; Aguiar, Carlos; Santos, Nuno; Carmo, Pedro; Figueira, João; Raposo, Luis; Gonçalves, Pedro; Silva, José Aniceto

2010-12-01

Abstract Objectives: Evaluate the new ESC/ACCF/AHA/WHF universal definition of myocardial infarction (MI) in relation to its prognostic implications and the role for guiding decision for revascularization. It was also compared with the multivariable based GRACE Risk Score (GRS). Single centre registry of 389 consecutive patients admitted with non-ST-segment elevation (NSTE) ACS. We calculated the adjusted HR & 95%CI for death/MI at 30-days and one-year follow-up, between the presence or absence of MI using: (1) universal definition: > 99th URL for cTnI (> 0.06 ng/ml) or MBm (> 3.2 ng/ml); (2) MBm > 2 × URL (> 12.2 ng/ml); 3) old WHO: MBact > 2 × URL (> 32U/l). Logistic analysis was performed to test the interaction between tertiles of biomarkers or GRS and the effect of revascularization on the outcome. The universal definition increased the incidence of MI in 3.5-fold for cTnI, but was not an independent predictor of outcome. The GRS was the only independent predictor of prognosis at 30-days and one-year. The interaction with the prognostic impact of revascularization was only present for the GRS categorized by tertiles. In a contemporary unselected population with NSTE-ACS, the universal definition of MI alone was not adequate for risk assessment and revascularization decision making. These purposes were fully addressed with the GRS.

[Social support in gender reassignment surgery].

PubMed

Hess, J; Kurth, I; Henkel, A; Panic, L; Rübben, H; Rossi Neto, R; Hess-Busch, Y

2017-02-01

Gender reassignment surgery (GRS) can lead to discrimination. This transition makes great demands on the individual and also affects the social environment. To evaluate the social support of male-to-female (MtF) transgender people. Group A comprised 254 consecutive MtF transsexuals, who received a penile inversion vaginoplasty between 2004 and 2010. These women were surveyed retrospectively. Group B comprised 144 consecutive MtF transsexuals who presented for preoperative counselling. These patients were asked to answer the survey in advance of the planned GRS. The return rate was 46.9 % (A) and 95.1 % (B). In both groups, approximately two-thirds lived with their parents or children at ease. About 13.4 % (A) and 16.9 % (B) estimated the relationship towards their parents and one- seventh (A) or one-sixth (B) woman rated their relationship towards their children as poor. The acceptance of the parents regarding GRS was 65.6 % (A) and 77.1 % (B). In total 20 % (A) and 9.2 % (B) did not, however, accept GRS in their children. The acceptance of children regarding GRS was 64.9 % (A) and 71.1 % (B) with 10.8 % (A) and 6.7 % (B) who did not approve the decision. Social support is an important resource in the context of gender reassignment surgery. Understanding can help to improve the situation for transsexuals and to reduce consecutive healthcare utilisation.

Increase of glucocorticoid receptor expression after environmental enrichment: relations to spatial memory, exploration and anxiety-related behaviors.

PubMed

Sampedro-Piquero, P; Begega, A; Arias, J L

2014-04-22

Environmental enrichment (EE) produces a remarkable degree of structural and functional plasticity in the hippocampus and possible mediators of these changes, such as glucocorticoid receptors (GRs), are of considerable interest. GRs are richly expressed in the hippocampus and they are involved in the adaptation to stressors and facilitate active coping in anxious situations. In this study, we assessed the effect of an EE protocol (24h/day during 69days) in adult Wistar rats on the activity in the elevated-zero maze (EZM), performance in the holeboard task (HB) and we also examined the changes in the glucocorticoid receptors (GRs) expression in the dorsal hippocampus (CA1, CA3 and DG). Our EE protocol reduced anxious behaviors in the EZM, so the animals spent more time and made more entries into the open sections. In the HB task, the enriched group showed more explorative behavior, a reduction of anxiety-related behaviors and a better cognitive performance compared to non-enriched animals. With regard to the GR expression, the EE condition produced an increase in the number of immunopositive cells for GRs in CA1, CA3 and DG. These results suggest that the better performance of enriched animals could be mediated in part by the increase of GRs in the dorsal hippocampus, which may alter the hippocampal neuronal function and accordingly, the anxiety levels, the spatial memory performance and the exploration levels in these animals. Copyright © 2014 Elsevier Inc. All rights reserved.

Gamma ray monitoring of a AGN and galactic black hole candidates by the Compton Gamma Ray Observatory

NASA Technical Reports Server (NTRS)

Skelton, R. T.; Ling, James C.; Wheaton, William A.; Harmon, Alan; Fishman, G. J.; Meegan, C. A.; Paciesas, William S.; Gruber, Duane E.; Rubin, Brad; Wilson, R. B.

1992-01-01

The Compton Gamma-Ray Observatory's Burst and Transient Source Experiment (BATSE) has a powerful capability to provide nearly uninterrupted monitoring in the 25 keV-10 MeV range of both active galactic nuclei (AGN) and galactic black hole candidates (GBHC) such as Cygnus X-1, using the occultation of cosmic sources by the Earth. Since the Crab is detected by the BATSE Large Area Detectors with roughly 25(sigma) significance in the 15-125 keV range in a single rise or set, a variation by a factor of two of a source having one-tenth the strength of Cygnus X-1 should be detectable within a day. Methods of modeling the background are discussed which will increase the accuracy, sensitivity, and reliability of the results beyond those obtainable from a linear background fit with a single rise or set discontinuity.

The nuclear window to the extragalactic universe

NASA Astrophysics Data System (ADS)

Erdmann, M.; Müller, G.; Urban, M.; Wirtz, M.

2016-12-01

We investigate two recent parameterizations of the galactic magnetic field with respect to their impact on cosmic nuclei traversing the field. We present a comprehensive study of the size of angular deflections, dispersion in the arrival probability distributions, multiplicity in the images of arrival on Earth, variance in field transparency, and influence of the turbulent field components. To remain restricted to ballistic deflections, a cosmic nucleus with energy E and charge Z should have a rigidity above E / Z = 6 EV. In view of the differences resulting from the two field parameterizations as a measure of current knowledge in the galactic field, this rigidity threshold may have to be increased. For a point source search with E/Z ≥ 60 EV, field uncertainties increase the required signal events for discovery moderately for sources in the northern and southern regions, but substantially for sources near the galactic disk.

Female Behaviour Drives Expression and Evolution of Gustatory Receptors in Butterflies

PubMed Central

Briscoe, Adriana D.; Macias-Muñoz, Aide; Kozak, Krzysztof M.; Walters, James R.; Yuan, Furong; Jamie, Gabriel A.; Martin, Simon H.; Dasmahapatra, Kanchon K.; Ferguson, Laura C.; Mallet, James; Jacquin-Joly, Emmanuelle; Jiggins, Chris D.

2013-01-01

Secondary plant compounds are strong deterrents of insect oviposition and feeding, but may also be attractants for specialist herbivores. These insect-plant interactions are mediated by insect gustatory receptors (Grs) and olfactory receptors (Ors). An analysis of the reference genome of the butterfly Heliconius melpomene, which feeds on passion-flower vines (Passiflora spp.), together with whole-genome sequencing within the species and across the Heliconius phylogeny has permitted an unprecedented opportunity to study the patterns of gene duplication and copy-number variation (CNV) among these key sensory genes. We report in silico gene predictions of 73 Gr genes in the H. melpomene reference genome, including putative CO2, sugar, sugar alcohol, fructose, and bitter receptors. The majority of these Grs are the result of gene duplications since Heliconius shared a common ancestor with the monarch butterfly or the silkmoth. Among Grs but not Ors, CNVs are more common within species in those gene lineages that have also duplicated over this evolutionary time-scale, suggesting ongoing rapid gene family evolution. Deep sequencing (∼1 billion reads) of transcriptomes from proboscis and labial palps, antennae, and legs of adult H. melpomene males and females indicates that 67 of the predicted 73 Gr genes and 67 of the 70 predicted Or genes are expressed in these three tissues. Intriguingly, we find that one-third of all Grs show female-biased gene expression (n = 26) and nearly all of these (n = 21) are Heliconius-specific Grs. In fact, a significant excess of Grs that are expressed in female legs but not male legs are the result of recent gene duplication. This difference in Gr gene expression diversity between the sexes is accompanied by a striking sexual dimorphism in the abundance of gustatory sensilla on the forelegs of H. melpomene, suggesting that female oviposition behaviour drives the evolution of new gustatory receptors in butterfly genomes. PMID:23950722

Genetic risk of prediabetes and diabetes development in chronic myeloid leukemia patients treated with nilotinib.

PubMed

Martino, Bruno; Mammì, Corrado; Labate, Claudia; Rodi, Silvia; Ielo, Domenica; Priolo, Manuela; Postorino, Maurizio; Tripepi, Giovanni; Ronco, Francesca; Laganà, Carmelo; Musolino, Caterina; Greco, Marianna; La Nasa, Giorgio; Caocci, Giovanni

2017-11-01

Impaired fasting glucose and type 2 diabetes represent adverse events in patients with chronic myeloid leukemia (CML) treated with the second generation tyrosine kinase inhibitor nilotinib. An unweighted genetic risk score (uGRS) for the prediction of insulin resistance, consisting of 10 multiple single-nucleotide polymorphisms, has been proposed. We evaluated uGRS predictivity in 61 CML patients treated with nilotinib. Patients were genotyped for IRS1, GRB14, ARL15, PPARG, PEPD, ANKRD55/MAP3K1, PDGFC, LYPLAL1, RSPO3, and FAM13A1 genes. The uGRS was based on the sum of the risk alleles within the set of selected single-nucleotide polymorphisms. Molecular response (MR) 3.0 and MR 4.0 were achieved in 90% and 79% of patients, respectively. Before treatment, none of the patients had abnormal blood glucose. During treatment and subsequent follow-up at 80.2 months (range: 1-298), seven patients (11.5%) had developed diabetes that required oral treatment, a median of 14 months (range: 3-98) after starting nilotinib treatment. Twelve patients (19.7%) had developed prediabetes. Prediabetes/diabetes-free survival was significantly higher in patients with a uGRS <10 than in those with higher scores (100% vs. 22.8 ± 12.4%, p <0.001). Each increment of one unit in the uGRS caused a 42% increase in the prediabetes/diabetes risk (hazard ratio = 1.42, confidence interval: 1.04-1.94, p = 0.026). The presence of more than 10 allelic variants associated with insulin secretion, processing, sensitivity, and clearance is predictive of prediabetes/diabetes development in CML patients treated with nilotinib. In clinical practice, uGRS could help tailor the best tyrosine kinase inhibitor therapy. Copyright © 2017 ISEH – Society for Hematology and Stem Cells. Published by Elsevier Inc. All rights reserved.

Validation of Type 2 Diabetes Risk Variants Identified by Genome-Wide Association Studies in Northern Han Chinese

PubMed Central

Rao, Ping; Zhou, Yong; Ge, Si-Qi; Wang, An-Xin; Yu, Xin-Wei; Alzain, Mohamed Ali; Veronica, Andrea Katherine; Qiu, Jing; Song, Man-Shu; Zhang, Jie; Wang, Hao; Fang, Hong-Hong; Gao, Qing; Wang, You-Xin; Wang, Wei

2016-01-01

Background: More than 60 genetic susceptibility loci associated with type 2 diabetes mellitus (T2DM) have been established in populations of Asian and European ancestry. Given ethnic differences and environmental factors, validation of the effects of genetic risk variants with reported associations identified by Genome-Wide Association Studies (GWASs) is essential. The study aims at evaluating the associations of T2DM with 29 single nucleotide polymorphisms (SNPs) from 19 candidate genes derived from GWASs in a northern Han Chinese population. Method: In this case-control study, 461 T2DM-diagnosed patients and 434 controls were recruited at the Jidong oil field hospital (Hebei, China) from January 2009 to October 2013. A cumulative genetic risk score (cGRS) was calculated by summation of the number of risk alleles, and a weight GRS (wGRS) was calculated as the sum of risk alleles at each locus multiplied by their effect sizes for T2DM, using the independent variants selected. Result: The allelic frequency of the “A” allele at rs17106184 (Fas-associated factor 1, FAF1) was significantly higher in the T2DM patients than that of the healthy controls (11.7% vs. 6.4%, p < 0.001). Individuals in the highestquartile of wGRS had an over three-fold increased risk for developing T2DM compared with those in the lowest quartile (odds ratio = 3.06, 95% CI = 1.92–4.88, p < 0.001) adjusted for age, sex, BMI, total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), systolic blood pressure (SBP) and diastolic blood pressure (DBP). The results were similar when analyzed with the cGRS. Conclusions: We confirmed the association between rs17106184 (FAF1) and T2DM in a northern Han Chinese population. The GRS calculated based on T2DM susceptibility variants may be a useful tool for predicting the T2DM susceptibility. PMID:27589775

A genetic risk score based on direct associations with coronary heart disease improves coronary heart disease risk prediction in the Atherosclerosis Risk in Communities (ARIC), but not in the Rotterdam and Framingham Offspring, Studies.

PubMed

Brautbar, Ariel; Pompeii, Lisa A; Dehghan, Abbas; Ngwa, Julius S; Nambi, Vijay; Virani, Salim S; Rivadeneira, Fernando; Uitterlinden, André G; Hofman, Albert; Witteman, Jacqueline C M; Pencina, Michael J; Folsom, Aaron R; Cupples, L Adrienne; Ballantyne, Christie M; Boerwinkle, Eric

2012-08-01

Multiple studies have identified single-nucleotide polymorphisms (SNPs) that are associated with coronary heart disease (CHD). We examined whether SNPs selected based on predefined criteria will improve CHD risk prediction when added to traditional risk factors (TRFs). SNPs were selected from the literature based on association with CHD, lack of association with a known CHD risk factor, and successful replication. A genetic risk score (GRS) was constructed based on these SNPs. Cox proportional hazards model was used to calculate CHD risk based on the Atherosclerosis Risk in Communities (ARIC) and Framingham CHD risk scores with and without the GRS. The GRS was associated with risk for CHD (hazard ratio [HR] = 1.10; 95% confidence interval [CI]: 1.07-1.13). Addition of the GRS to the ARIC risk score significantly improved discrimination, reclassification, and calibration beyond that afforded by TRFs alone in non-Hispanic whites in the ARIC study. The area under the receiver operating characteristic curve (AUC) increased from 0.742 to 0.749 (Δ = 0.007; 95% CI, 0.004-0.013), and the net reclassification index (NRI) was 6.3%. Although the risk estimates for CHD in the Framingham Offspring (HR = 1.12; 95% CI: 1.10-1.14) and Rotterdam (HR = 1.08; 95% CI: 1.02-1.14) Studies were significantly improved by adding the GRS to TRFs, improvements in AUC and NRI were modest. Addition of a GRS based on direct associations with CHD to TRFs significantly improved discrimination and reclassification in white participants of the ARIC Study, with no significant improvement in the Rotterdam and Framingham Offspring Studies. Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

Validation of a polygenic risk score for dementia in black and white individuals

PubMed Central

Marden, Jessica R; Walter, Stefan; Tchetgen Tchetgen, Eric J; Kawachi, Ichiro; Glymour, M Maria

2014-01-01

Objective To determine whether a polygenic risk score for Alzheimer's disease (AD) predicts dementia probability and memory functioning in non-Hispanic black (NHB) and non-Hispanic white (NHW) participants from a sample not used in previous genome-wide association studies. Methods Non-Hispanic white and NHB Health and Retirement Study (HRS) participants provided genetic information and either a composite memory score (n = 10,401) or a dementia probability score (n = 7690). Dementia probability score was estimated for participants' age 65+ from 2006 to 2010, while memory score was available for participants age 50+. We calculated AD genetic risk scores (AD-GRS) based on 10 polymorphisms confirmed to predict AD, weighting alleles by beta coefficients reported in AlzGene meta-analyses. We used pooled logistic regression to estimate the association of the AD-GRS with dementia probability and generalized linear models to estimate its effect on memory score. Results Each 0.10 unit change in the AD-GRS was associated with larger relative effects on dementia among NHW aged 65+ (OR = 2.22; 95% CI: 1.79, 2.74; P < 0.001) than NHB (OR=1.33; 95% CI: 1.00, 1.77; P = 0.047), although additive effect estimates were similar. Each 0.10 unit change in the AD-GRS was associated with a −0.07 (95% CI: −0.09, −0.05; P < 0.001) SD difference in memory score among NHW aged 50+, but no significant differences among NHB (β = −0.01; 95% CI: −0.04, 0.01; P = 0.546). [Correction added on 29 July 2014, after first online publication: confidence intervalshave been amended.] The estimated effect of the GRS was significantly smaller among NHB than NHW (P < 0.05) for both outcomes. Conclusion This analysis provides evidence for differential relative effects of the GRS on dementia probability and memory score among NHW and NHB in a new, national data set. PMID:25328845

Reliability and Validity of 3 Methods of Assessing Orthopedic Resident Skill in Shoulder Surgery.

PubMed

Bernard, Johnathan A; Dattilo, Jonathan R; Srikumaran, Uma; Zikria, Bashir A; Jain, Amit; LaPorte, Dawn M

Traditional measures for evaluating resident surgical technical skills (e.g., case logs) assess operative volume but not level of surgical proficiency. Our goal was to compare the reliability and validity of 3 tools for measuring surgical skill among orthopedic residents when performing 3 open surgical approaches to the shoulder. A total of 23 residents at different stages of their surgical training were tested for technical skill pertaining to 3 shoulder surgical approaches using the following measures: Objective Structured Assessment of Technical Skills (OSATS) checklists, the Global Rating Scale (GRS), and a final pass/fail assessment determined by 3 upper extremity surgeons. Adverse events were recorded. The Cronbach α coefficient was used to assess reliability of the OSATS checklists and GRS scores. Interrater reliability was calculated with intraclass correlation coefficients. Correlations among OSATS checklist scores, GRS scores, and pass/fail assessment were calculated with Spearman ρ. Validity of OSATS checklists was determined using analysis of variance with postgraduate year (PGY) as a between-subjects factor. Significance was set at p < 0.05 for all tests. Criterion validity was shown between the OSATS checklists and GRS for the 3 open shoulder approaches. Checklist scores showed superior interrater reliability compared with GRS and subjective pass/fail measurements. GRS scores were positively correlated across training years. The incidence of adverse events was significantly higher among PGY-1 and PGY-2 residents compared with more experienced residents. OSATS checklists are a valid and reliable assessment of technical skills across 3 surgical shoulder approaches. However, checklist scores do not measure quality of technique. Documenting adverse events is necessary to assess quality of technique and ultimate pass/fail status. Multiple methods of assessing surgical skill should be considered when evaluating orthopedic resident surgical performance. Copyright © 2016 Association of Program Directors in Surgery. Published by Elsevier Inc. All rights reserved.

Interaction between polygenic risk for cigarette use and environmental exposures in the Detroit Neighborhood Health Study.

PubMed

Meyers, J L; Cerdá, M; Galea, S; Keyes, K M; Aiello, A E; Uddin, M; Wildman, D E; Koenen, K C

2013-08-13

Cigarette smoking is influenced both by genetic and environmental factors. Until this year, all large-scale gene identification studies on smoking were conducted in populations of European ancestry. Consequently, the genetic architecture of smoking is not well described in other populations. Further, despite a rich epidemiologic literature focused on the social determinants of smoking, few studies have examined the moderation of genetic influences (for example, gene-environment interactions) on smoking in African Americans. In the Detroit Neighborhood Health Study (DNHS), a sample of randomly selected majority African American residents of Detroit, we constructed a genetic risk score (GRS), in which we combined top (P-value <5 × 10(-7)) genetic variants from a recent meta-analysis conducted in a large sample of African Americans. Using regression (effective n=399), we first tested for association between the GRS and cigarettes per day, attempting to replicate the findings from the meta-analysis. Second, we examined interactions with three social contexts that may moderate the genetic association with smoking: traumatic events, neighborhood social cohesion and neighborhood physical disorder. Among individuals who had ever smoked cigarettes, the GRS significantly predicted the number of cigarettes smoked per day and accounted for ~3% of the overall variance in the trait. Significant interactions were observed between the GRS and number of traumatic events experienced, as well as between the GRS and average neighborhood social cohesion; the association between genetic risk and smoking was greater among individuals who had experienced an increased number of traumatic events in their lifetimes, and diminished among individuals who lived in a neighborhood characterized by greater social cohesion. This study provides support for the utility of the GRS as an alternative approach to replication of common polygenic variation, and in gene-environment interaction, for smoking behaviors. In addition, this study indicates that environmental determinants have the potential to both exacerbate (traumatic events) and diminish (neighborhood social cohesion) genetic influences on smoking behaviors.

Blood Pressure Genetic Risk Score Predicts Blood Pressure Responses to Dietary Sodium and Potassium: The GenSalt Study (Genetic Epidemiology Network of Salt Sensitivity).

PubMed

Nierenberg, Jovia L; Li, Changwei; He, Jiang; Gu, Dongfeng; Chen, Jichun; Lu, Xiangfeng; Li, Jianxin; Wu, Xigui; Gu, C Charles; Hixson, James E; Rao, Dabeeru C; Kelly, Tanika N

2017-12-01

We examined the association between genetic risk score (GRS) for blood pressure (BP), based on single nucleotide polymorphisms identified in previous BP genome-wide association study meta-analyses, and salt and potassium sensitivity of BP among participants of the GenSalt study (Genetic Epidemiology Network of Salt Sensitivity). The GenSalt study was conducted among 1906 participants who underwent a 7-day low-sodium (51.3 mmol sodium/d), 7-day high-sodium (307.8 mmol sodium/d), and 7-day high-sodium plus potassium (60 mmol potassium/d) intervention. BP was measured 9× at baseline and at the end of each intervention period using a random zero sphygmomanometer. Associations between systolic BP (SBP), diastolic BP, and mean arterial pressure GRS and respective SBP, diastolic BP, and mean arterial pressure responses to the dietary interventions were assessed using mixed linear regression models that accounted for familial dependencies and adjusted for age, sex, field center, body mass index, and baseline BP. As expected, baseline SBP, diastolic BP, and mean arterial pressure significantly increased per quartile increase in GRS ( P =2.7×10 -8 , 9.8×10 -8 , and 6.4×10 -6 , respectively). In contrast, increasing GRS quartile conferred smaller SBP, diastolic BP, and mean arterial pressure responses to the low-sodium intervention ( P =1.4×10 -3 , 0.02, and 0.06, respectively) and smaller SBP responses to the high-sodium and potassium interventions ( P =0.10 and 0.05). In addition, overall findings were similar when examining GRS as a continuous measure. Contrary to our initial hypothesis, we identified an inverse relationship between BP GRS and salt and potassium sensitivity of BP. These data may provide novel implications on the relationship between BP responses to dietary sodium and potassium and hypertension. © 2017 American Heart Association, Inc.

Interaction between polygenic risk for cigarette use and environmental exposures in the Detroit neighborhood health study

PubMed Central

Meyers, J L; Cerdá, M; Galea, S; Keyes, K M; Aiello, A E; Uddin, M; Wildman, D E; Koenen, K C

2013-01-01

Cigarette smoking is influenced both by genetic and environmental factors. Until this year, all large-scale gene identification studies on smoking were conducted in populations of European ancestry. Consequently, the genetic architecture of smoking is not well described in other populations. Further, despite a rich epidemiologic literature focused on the social determinants of smoking, few studies have examined the moderation of genetic influences (for example, gene–environment interactions) on smoking in African Americans. In the Detroit Neighborhood Health Study (DNHS), a sample of randomly selected majority African American residents of Detroit, we constructed a genetic risk score (GRS), in which we combined top (P-value <5 × 10−7) genetic variants from a recent meta-analysis conducted in a large sample of African Americans. Using regression (effective n=399), we first tested for association between the GRS and cigarettes per day, attempting to replicate the findings from the meta-analysis. Second, we examined interactions with three social contexts that may moderate the genetic association with smoking: traumatic events, neighborhood social cohesion and neighborhood physical disorder. Among individuals who had ever smoked cigarettes, the GRS significantly predicted the number of cigarettes smoked per day and accounted for ∼3% of the overall variance in the trait. Significant interactions were observed between the GRS and number of traumatic events experienced, as well as between the GRS and average neighborhood social cohesion; the association between genetic risk and smoking was greater among individuals who had experienced an increased number of traumatic events in their lifetimes, and diminished among individuals who lived in a neighborhood characterized by greater social cohesion. This study provides support for the utility of the GRS as an alternative approach to replication of common polygenic variation, and in gene–environment interaction, for smoking behaviors. In addition, this study indicates that environmental determinants have the potential to both exacerbate (traumatic events) and diminish (neighborhood social cohesion) genetic influences on smoking behaviors. PMID:23942621

Detection of gene-environment interactions in the presence of linkage disequilibrium and noise by using genetic risk scores with internal weights from elastic net regression.

PubMed

Hüls, Anke; Ickstadt, Katja; Schikowski, Tamara; Krämer, Ursula

2017-06-12

For the analysis of gene-environment (GxE) interactions commonly single nucleotide polymorphisms (SNPs) are used to characterize genetic susceptibility, an approach that mostly lacks power and has poor reproducibility. One promising approach to overcome this problem might be the use of weighted genetic risk scores (GRS), which are defined as weighted sums of risk alleles of gene variants. The gold-standard is to use external weights from published meta-analyses. In this study, we used internal weights from the marginal genetic effects of the SNPs estimated by a multivariate elastic net regression and thereby provided a method that can be used if there are no external weights available. We conducted a simulation study for the detection of GxE interactions and compared power and type I error of single SNPs analyses with Bonferroni correction and corresponding analysis with unweighted and our weighted GRS approach in scenarios with six risk SNPs and an increasing number of highly correlated (up to 210) and noise SNPs (up to 840). Applying weighted GRS increased the power enormously in comparison to the common single SNPs approach (e.g. 94.2% vs. 35.4%, respectively, to detect a weak interaction with an OR ≈ 1.04 for six uncorrelated risk SNPs and n = 700 with a well-controlled type I error). Furthermore, weighted GRS outperformed the unweighted GRS, in particular in the presence of SNPs without any effect on the phenotype (e.g. 90.1% vs. 43.9%, respectively, when 20 noise SNPs were added to the six risk SNPs). This outperforming of the weighted GRS was confirmed in a real data application on lung inflammation in the SALIA cohort (n = 402). However, in scenarios with a high number of noise SNPs (>200 vs. 6 risk SNPs), larger sample sizes are needed to avoid an increased type I error, whereas a high number of correlated SNPs can be handled even in small samples (e.g. n = 400). In conclusion, weighted GRS with weights from the marginal genetic effects of the SNPs estimated by a multivariate elastic net regression were shown to be a powerful tool to detect gene-environment interactions in scenarios of high Linkage disequilibrium and noise.

Expression map of a complete set of gustatory receptor genes in chemosensory organs of Bombyx mori.

PubMed

Guo, Huizhen; Cheng, Tingcai; Chen, Zhiwei; Jiang, Liang; Guo, Youbing; Liu, Jianqiu; Li, Shenglong; Taniai, Kiyoko; Asaoka, Kiyoshi; Kadono-Okuda, Keiko; Arunkumar, Kallare P; Wu, Jiaqi; Kishino, Hirohisa; Zhang, Huijie; Seth, Rakesh K; Gopinathan, Karumathil P; Montagné, Nicolas; Jacquin-Joly, Emmanuelle; Goldsmith, Marian R; Xia, Qingyou; Mita, Kazuei

2017-03-01

Most lepidopteran species are herbivores, and interaction with host plants affects their gene expression and behavior as well as their genome evolution. Gustatory receptors (Grs) are expected to mediate host plant selection, feeding, oviposition and courtship behavior. However, due to their high diversity, sequence divergence and extremely low level of expression it has been difficult to identify precisely a complete set of Grs in Lepidoptera. By manual annotation and BAC sequencing, we improved annotation of 43 gene sequences compared with previously reported Grs in the most studied lepidopteran model, the silkworm, Bombyx mori, and identified 7 new tandem copies of BmGr30 on chromosome 7, bringing the total number of BmGrs to 76. Among these, we mapped 68 genes to chromosomes in a newly constructed chromosome distribution map and 8 genes to scaffolds; we also found new evidence for large clusters of BmGrs, especially from the bitter receptor family. RNA-seq analysis of diverse BmGr expression patterns in chemosensory organs of larvae and adults enabled us to draw a precise organ specific map of BmGr expression. Interestingly, most of the clustered genes were expressed in the same tissues and more than half of the genes were expressed in larval maxillae, larval thoracic legs and adult legs. For example, BmGr63 showed high expression levels in all organs in both larval and adult stages. By contrast, some genes showed expression limited to specific developmental stages or organs and tissues. BmGr19 was highly expressed in larval chemosensory organs (especially antennae and thoracic legs), the single exon genes BmGr53 and BmGr67 were expressed exclusively in larval tissues, the BmGr27-BmGr31 gene cluster on chr7 displayed a high expression level limited to adult legs and the candidate CO 2 receptor BmGr2 was highly expressed in adult antennae, where few other Grs were expressed. Transcriptional analysis of the Grs in B. mori provides a valuable new reference for finding genes involved in plant-insect interactions in Lepidoptera and establishing correlations between these genes and vital insect behaviors like host plant selection and courtship for mating. Copyright © 2017 The Author(s). Published by Elsevier Ltd.. All rights reserved.

Description of Galbitalea soli gen. nov., sp. nov., and Frondihabitans sucicola sp. nov.

PubMed

Kim, Soo-Jin; Lim, Jun-Muk; Ahn, Jae-Hyung; Weon, Hang-Yeon; Hamada, Moriyuki; Suzuki, Ken-ichiro; Ahn, Tae-Young; Kwon, Soon-Wo

2014-02-01

Bacterial strains KIS82-1(T) and GRS42(T) were isolated from soil and from sap of Acer mono, respectively, in the Republic of Korea. Both strains were aerobic, Gram-stain-positive, mesophilic, rod-shaped and motile. Phylogenetically, both strains belonged to the family Microbacteriaceae of the phylum Actinobacteria. The 16S rRNA gene sequence of strain KIS82-1(T) showed the highest similarity to those of Frondihabitans peucedani RS-15(T) (97.6%), Frigoribacterium mesophilum MSL-08(T) (97.2%) and Labedella gwakjiensis KSW2-17(T) (97.0%), while strain GRS42(T) showed the highest 16S rRNA gene sequence similarity to Frondihabitans peucedani RS-15(T) (98.7%), Frondihabitans cladoniiphilus CafT13(T) (98.4%), Frondihabitans australicus E1HC-02(T) (98.2%) and Frigoribacterium faeni 801(T) (97.3%). The 16S rRNA gene sequence similarity between GRS42(T) and KIS82-1(T) was 97.0%. Phylogenetic trees indicated that strain GRS42(T) was firmly grouped into the genus Frondihabitans, while strain KIS82-1(T) did not show a clear affiliation to any genus within the family Microbacteriaceae. Strain KIS82-1(T) showed type B1β peptidoglycan with 2,4-diamino-L-butyric acid as the diamino acid. It had MK-11, MK-10 and MK-12 as respiratory quinones, anteiso-C(15 : 0), iso-C(16: 0) and iso-C(14 : 0) as major cellular fatty acids and diphosphatidylglycerol, phosphatidylglycerol and an unknown glycolipid as predominant polar lipids. The peptidoglycan of strain GRS42(T) was of type B2β with D-ornithine as the diamino acid. The strain contained MK-8, MK-9 and MK-7 as respiratory quinones, summed feature 8 (C(18 : 1)ω6c and/or C(18 : 1)ω7c) as major cellular fatty acid and diphosphatidylglycerol, phosphatidylglycerol and three unknown glycolipids as predominant polar lipids. Strain GRS42(T) revealed low DNA-DNA hybridization (<50% relatedness) with closely related strains. Based on the data obtained in the present polyphasic taxonomic study, we propose that strain KIS82-1(T) represents a novel genus and species and that strain GRS42(T) represents a novel species in the family Microbacteriaceae. The genus Galbitalea gen. nov. is proposed, with strain KIS82-1(T) ( = KACC 15520(T) = NBRC 108727(T)) as the type strain of the type species, Galbitalea soli sp. nov. Strain GRS42(T) ( = KACC 15521(T) = NBRC 108728(T)) is proposed as the type strain of Frondihabitans sucicola sp. nov.

Galactic Bulge Giants: Probing Stellar and Galactic Evolution. 1. Catalogue of Spitzer IRAC and MIPS Sources (PREPRINT)

NASA Technical Reports Server (NTRS)

Uttenthaler, Stefan; Stute, Matthias; Sahai, Raghvendra; Blommaert, Joris A.; Schultheis, Mathias; Kraemer, Kathleen E.; Groenewegen, Martin A.; Price, Stephan D.

2010-01-01

Aims. We aim at measuring mass-loss rates and the luminosities of a statistically large sample of Galactic bulge stars at several galactocentric radii. The sensitivity of previous infrared surveys of the bulge has been rather limited, thus fundamental questions for late stellar evolution, such as the stage at which substantial mass-loss begins on the red giant branch and its dependence on fundamental stellar properties, remain unanswered. We aim at providing evidence and answers to these questions. Methods. To this end, we observed seven 15 15 arcmin2 fields in the nuclear bulge and its vicinity with unprecedented sensitivity using the IRAC and MIPS imaging instruments on-board the Spitzer Space Telescope. In each of the fields, tens of thousands of point sources were detected. Results. In the first paper based on this data set, we present the observations, data reduction, the final catalogue of sources, and a detailed comparison to previous mid-IR surveys of the Galactic bulge, as well as to theoretical isochrones. We find in general good agreement with other surveys and the isochrones, supporting the high quality of our catalogue.

X-ray Binaries and the Galaxy Structure in Hard X-rays

NASA Astrophysics Data System (ADS)

Lutovinov, Alexander

The Galaxy structure in the hard X-ray energy band (¿20 keV) was studied using data of the INTEGRAL observatory. A deep and nearly uniform coverage of the galactic plane allowed to increase significantly the sensitivity of the survey and discover several dozens new galac-tic sources. The follow-up observations with XMM-Newton and CHANDRA observatories in X-rays and ground-based telescopes in optical and infrared wavebands gave us a possibility to determine optical counterparts and distances for number of new and already known faint sources. That, in turn, allowed us to build the spatial distribution of different classes of galactic X-ray binaries and obtain preliminary results of the structure of the further part of the Galaxy.

Gravitational lensing by a massive black hole at the Galactic center

NASA Technical Reports Server (NTRS)

Wardle, Mark; Yusef-Zadeh, Farhad

1992-01-01

The manifestations of gravitational lensing by a massive black hole at the Galactic center, with particular attention given to lensing of stars in the stellar cluster that lie behind Sgr A*, and of Sgr A east, a nonthermal extended radio source which is known with certainty to lie behind the Galactic center. Lensing of the stellar cluster produces a deficit of stellar images within 10 mas of the center, and a surplus between 30 and 300 mas. The results suggest that the proper motion of the stars will produce brightness variations of stellar images on a time scale of a few years or less. Both images of such a source should be visible, and will rise and fall in luminosity together.

Gravitational lensing of active galactic nuclei.

PubMed Central

Hewitt, J N

1995-01-01

Most of the known cases of strong gravitational lensing involve multiple imaging of an active galactic nucleus. The properties of lensed active galactic nuclei make them promising systems for astrophysical applications of gravitational lensing; in particular, they show structure on scales of milliseconds of arc to tens of seconds of arc, they are variable, and they are polarized. More than 20 cases of strong gravitational lenses are now known, and about half of them are radio sources. High-resolution radio imaging is making possible the development of well-constrained lens models. Variability studies at radio and optical wavelengths are beginning to yield results of astrophysical interest, such as an independent measure of the distance scale and limits on source sizes. PMID:11607613

How to Schedule Multiple Graphical Representations? A Classroom Experiment with an Intelligent Tutoring System for Fractions

ERIC Educational Resources Information Center

Rau, M. A.; Aleven, V.; Rummel, N.

2011-01-01

Graphical representations (GRs) of the learning content are often used for instruction (Ainsworth, 2006). When used in learning technology, GRs can be especially useful since they allow for interactions across representations that are physically impossible, for instance by dragging and dropping symbolic statements into a chart that automatically…

Extensive Reading for Second Language Learners of Japanese in Higher Education: Graded Readers and Beyond

ERIC Educational Resources Information Center

Nakano, Teiko

2016-01-01

This paper reports on the implementation of Japanese extensive reading with international students studying at a Japanese university using graded readers (GRs). GRs chosen for the present study were simplified versions of original Japanese literature and were used to support students in acquiring a top-down reading strategy, a wide range of…

Muscle Dysmorphia, Gender Role Stress, and Sociocultural Influences: An Exploratory Study

ERIC Educational Resources Information Center

Readdy, Tucker; Watkins, Patti Lou; Cardinal, Bradley J.

2011-01-01

Our study explored the contribution of gender role stress (GRS) and sociocultural appearance demands to symptoms of muscle dysmorphia (MD) in a college sample of 219 women and 154 men. For women, five GRS subscales, sociocultural appearance demands, age, and frequency of aerobic exercise predicted MD symptoms (model R[superscript 2] = 0.33;…

Muscle dysmorphia, gender role stress, and sociocultural influences: an exploratory study.

PubMed

Tucker, Readdy; Watkins, Patti Lou; Cardinal, Bradley J

2011-06-01

Our study explored the contribution of gender role stress (GRS) and sociocultural appearance demands to symptoms of muscle dysmorphia (MD) in a college sample of 219 women and 154 men. For women, five GRS subscales, sociocultural appearance demands, age, and frequency of aerobic exercise predicted MD symptoms (model R2 = .33; F(8,210) = 12.81, p < . 001); for men, only one GRS subscale, age, and sociocultural appearance demands predicted MD symptoms (model R2 = .40; F(3,150) = 9.52, p < .001). Post hoc analyses revealed that a small number of items explained a substantial portion of the variation, suggesting that MD may be more related to specific perceptions of pressure to attain an attractive body than to global gender role stress.

A Spectroscopic and Photometric Study of Gravitational Microlensing Events

NASA Astrophysics Data System (ADS)

Kane, Stephen R.

2000-08-01

Gravitational microlensing has generated a great deal of scientific interest over recent years. This has been largely due to the realization of its wide-reaching applications, such as the search for dark matter, the detection of planets, and the study of Galactic structure. A significant observational advance has been that most microlensing events can be identified in real-time while the source is still being lensed. More than 400 microlensing events have now been detected towards the Galactic bulge and Magellanic Clouds by the microlensing survey teams EROS, MACHO, OGLE, DUO, and MOA. The real-time detection of these events allows detailed follow-up observations with much denser sampling, both photometrically and spectroscopically. The research undertaken in this project on photometric studies of gravitational microlensing events has been performed as a member of the PLANET (Probing Lensing Anomalies NETwork) collaboration. This is a worldwide collaboration formed in the early part of 1995 to study microlensing anomalies - departures from an achromatic point source, point lens light curve - through rapidly-sampled, multi-band, photometry. PLANET has demonstrated that it can achieve 1% photometry under ideal circumstances, making PLANET observations sensitive to detection of Earth-mass planets which require characterization of 1%--2% deviations from a standard microlensing light curve. The photometric work in this project involved over 5 months using the 1.0 m telescope at Canopus Observatory in Australia, and 3 separate observing runs using the 0.9 m telescope at the Cerro Tololo Inter-American Observatory (CTIO) in Chile. Methods were developed to reduce the vast amount of photometric data using the image analysis software MIDAS and the photometry package DoPHOT. Modelling routines were then written to analyse a selection of the resulting light curves in order to detect any deviation from an achromatic point source - point lens light curve. The photometric results presented in this thesis are from observations of 34 microlensing events over three consecutive bulge seasons. These results are presented along with a discussion of the observations and the data reduction procedures. The colour-magnitude diagrams indicate that the microlensed sources are main sequence and red clump giant stars. Most of the events appear to exhibit standard Paczynski point source - point lens curves whilst a few deviate significantly from the standard model. Various microlensing models that include anomalous structure are fitted to a selection of the observed events resulting in the discovery of a possible binary source event. These fitted events are used to estimate the sensitivity to extra-solar planets and it is found that the sampling rate for these events was insufficient by about a factor of 7.5 for detecting a Jupiter-mass planet. This result assumes that deviations of 5% can be reliably detected. If microlensing is caused predominantly by bulge stars, as has been suggested by Kiraga and Paczynski, the lensed stars should have larger extinction than other observed stars since they would preferentially be located at the far side of the Galactic bulge. Hence, spectroscopy of Galactic microlensing events may be used as a tool for studying the kinematics and extinction effects in the Galactic bulge. The spectroscopic work in this project involved using Kurucz model spectra to create theoretical extinction effects for various spectral classes towards the Galactic centre. These extinction effects are then used to interpret spectroscopic data taken with the 3.6 m ESO telescope. These data consist of a sample of microlensed stars towards the Galactic bulge and are used to derive the extinction offsets of the lensed source with respect to the average population and a measurement of the fraction of bulge-bulge lensing is made. Hence, it is shown statistically that the microlensed sources are generally located on the far side of the Galactic bulge. Measurements of the radial velocities of these sources are used to determine the kinematic properties of the far side of the Galactic bulge.

Cosmic cannibals

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tucker, W.

1980-06-01

The collision and subsequent assimilation of small galaxies by larger ones are examined in connection with cD galaxy radio sources. The dynamic-friction galactic-cannibalism theory is reviewed. It is noted that galactic cannibalism accounts for the relative absence of bright galaxies other than cD galaxies in rich clusters.

HEAO 1 measurements of the galactic ridge

NASA Technical Reports Server (NTRS)

Worrall, D. M.; Marshall, F. E.; Boldt, E. A.; Swank, J. H.

1981-01-01

The HEAO A2 experiment data was systematically searched for unresolved galactic disc emission. Although there were suggestions of non-uniformities in the emission, the data were consistent with a disc of half-thickness 241 + 22 pc and surface emissivity (2-10 keV) at galactic radius R(kpc) of 2.2 10 to the minus 7th power exp(-R/3.5) erg/sq cm to the (-2)power/s (R 7.8 kpc). giving a luminosity of approximately 4.4 10 to the 37th power erg S to the (-1) power. If the model is extrapolated to radii less than 7.8 kpc, the unresolved disc emission is approximately 1.4 10 to the 38th power erg S to the (-1) power (2-10 keV) i.e., a few percent of the luminosity of the galaxy in resolved sources. the disc emission has a spectrum which is significantly softer than that of the high galactic latitude diffuse X-ray background and it is most probably of discrete source origin.

Astronomical Data Center Bulletin, volume 1, number 3

NASA Technical Reports Server (NTRS)

Mead, J. M.; Warren, W. H., Jr.; Nagy, T. A.

1983-01-01

A catalog of galactic O-type stars, a machine-readable version of the bright star catalog, a two-micron sky survey, sky survey sources with problematical Durchmusterung identifications, data retrieval for visual binary stars, faint blue objects, the sixth catalog of galactic Wolf-Rayet stars, declination versus magnitude distribution, the SAO-HD-GC-DM cross index catalog, star cross-identification tables, astronomical sources, bibliographical star index search updates, DO-HD and HD-DO cross indices, and catalogs, are reviewed.

Uncorrelated Far Active Galactic Nuclei Flaring with Their Delayed Ultra High Energy Cosmic Rays Events

NASA Astrophysics Data System (ADS)

Fargion, Daniele; Oliva, Pietro; De Sanctis Lucentini, Pier Giorgio

The most distant Active Galactic Nuclei (AGN), within the allowed Greisen-Zatsepin-Kuzmin (GZK) cut-off radius ( ≲ 100 Mpc), have been recently candidate by many authors as the best location for the observed Ultra High Energy Cosmic Rays (UHECR) origination. Indeed, the apparent homogeneity and isotropy of recent UHECR signals seems to require a far cosmic isotropic and homogeneous scenario, involving a proton UHECR courier: our galaxy or nearest local group or super galactic plane (ruled by the Virgo cluster) are too near and apparently too anisotropic to be in agreement with the (Pierre Auger Observatory (PAO) and Telescope Array (TA) almost-homogeneous data sample. However, the few and mild UHECR observed clustering, the so called North and South Hot Spots, are smeared in wide (±18°) solid angles. Their consequent random walk flight from most far GZK UHECR sources, nearly at 100 Mpc, must be delayed — withrespect to a straight AGN photon gamma flaring arrival trajectory — at least by a million years. During this time, the AGN jet blazing signal, its probable axis deflection (such as the helical jet in Mrk 501), its miss alignment or even its almost certain exhaust activity, may lead to a complete misleading correlation between present UHECR events and a much earlier active AGN ejection. UHECR maps may be anyway related to galactic or nearest (Cen A, M82) AGN extragalactic UHECR sources shining in twin Hot Spot. Therefore we defend our (quite different) scenario where UHECR are mostly made by lightest UHECR nuclei originated by nearby AGN sources, or few galactic sources, whose delayed signals are reaching us within few thousand years in the observed smeared sky areas.

Identification of Hard X-ray Sources in Galactic Globular Clusters: Simbol-X Simulations

NASA Astrophysics Data System (ADS)

Servillat, M.

2009-05-01

Globular clusters harbour an excess of X-ray sources compared to the number of X-ray sources in the Galactic plane. It has been proposed that many of these X-ray sources are cataclysmic variables that have an intermediate magnetic field, i.e. intermediate polars, which remains to be confirmed and understood. We present here several methods to identify intermediate polars in globular clusters from multiwavelength analysis. First, we report on XMM-Newton, Chandra and HST observations of the very dense Galactic globular cluster NGC 2808. By comparing UV and X-ray properties of the cataclysmic variable candidates, the fraction of intermediate polars in this cluster can be estimated. We also present the optical spectra of two cataclysmic variables in the globular cluster M 22. The HeII (4868 Å) emission line in these spectra could be related to the presence of a magnetic field in these objects. Simulations of Simbol-X observations indicate that the angular resolution is sufficient to study X-ray sources in the core of close, less dense globular clusters, such as M 22. The sensitivity of Simbol-X in an extended energy band up to 80 keV will allow us to discriminate between hard X-ray sources (such as magnetic cataclysmic variables) and soft X-ray sources (such as chromospherically active binaries).

A Deep ROSAT HRI Observation of NGC 1313

NASA Astrophysics Data System (ADS)

Schlegel, Eric M.; Petre, Robert; Colbert, E. J. M.; Miller, Scott

2000-11-01

We describe a series of observations of NGC 1313 using the ROSAT HRI with a combined exposure time of 183.5 ks. The observations span an interval between 1992 and 1998; the purpose of observations since 1994 was to monitor the X-ray flux of SN 1978K, one of several luminous sources in the galaxy. No diffuse emission is detected in the galaxy to a level of ~1-2×1037 ergs s-1 arcmin-2. A total of eight sources are detected in the summed image within the D25 diameter of the galaxy. The luminosities of five of the eight range from ~6×1037 to ~6×1038 ergs s-1 these sources are most likely accreting X-ray binaries, similar to sources observed in M31 and M33. The remaining three sources all emit above 1039 ergs s-1. We present light curves of the five brightest sources. Variability is detected at the 99.9% level in four of these. We identify one of the sources as an NGC 1313 counterpart of a Galactic X-ray source. The light curve, though crudely sampled, most closely resembles that of a Galactic black hole candidate such as GX 339-4 but with considerably higher peak X-ray luminosity. An additional seven sources lie outside the D25 diameter and are either foreground stars or background active galactic nuclei.

Copernicus observations of a number of galactic X-ray sources

NASA Technical Reports Server (NTRS)

Culhane, J. L.; Mason, K. O.; Sanford, P. W.; White, N. E.

1976-01-01

The Copernicus satellite was launched on 21 August 1972. The main experiment on board is the University of Princeton UV telescope. In addition a cosmic X-ray package of somewhat modest aperture was provided by the Mullard Space Science Laboratory (MSSL) of University College London. Following a brief description of the instrument, a list of galactic sources observed during the year is presented. Although the X-ray detection aperture is small, the ability to point the satellite for long periods of time with high accuracy makes Copernicus an ideal vehicle for the study of variable sources.

A lower bound on the number of cosmic ray events required to measure source catalogue correlations

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dolci, Marco; Romero-Wolf, Andrew; Wissel, Stephanie, E-mail: marco.dolci@polito.it, E-mail: Andrew.Romero-Wolf@jpl.nasa.gov, E-mail: swissel@calpoly.edu

2016-10-01

Recent analyses of cosmic ray arrival directions have resulted in evidence for a positive correlation with active galactic nuclei positions that has weak significance against an isotropic source distribution. In this paper, we explore the sample size needed to measure a highly statistically significant correlation to a parent source catalogue. We compare several scenarios for the directional scattering of ultra-high energy cosmic rays given our current knowledge of the galactic and intergalactic magnetic fields. We find significant correlations are possible for a sample of >1000 cosmic ray protons with energies above 60 EeV.

Thorium abundances on the aristarchus plateau: Insights into the composition of the aristarchus pyroclastic glass deposits

USGS Publications Warehouse

Hagerty, Justin J.; Lawrence, D.J.; Hawke, B.R.; Gaddis, Lisa R.

2009-01-01

Thorium (Th) data from the Lunar Prospector gamma ray spectrometer (LP-GRS) are used to constrain the composition of lunar pyroclastic glass deposits on top of the Aristarchus plateau. Our goal is to use forward modeling of LP-GRS Th data to measure the Th abundances on the plateau and then to determine if the elevated Th abundances on the plateau are associated with the pyroclastic deposits or with thorium-rich ejecta from Aristarchus crater. We use a variety of remote sensing data to show that there is a large, homogenous portion of the pyroclastics on the plateau that has seen little or no contamination from the Th-rich ejecta of Aristarchus crater. Our results show that the uncontaminated pyroclastic glasses on Aristarchus plateau have an average Th content of 6.7 ppm and ???7 wt % TiO2. These Th and Ti values are consistent with Th-rich, intermediate-Ti yellow glasses from the lunar sample suite. On the basis of this information, we use petrologic equations and interelement correlations for the Moon to estimate the composition of the source region from which the Aristarchus glasses were derived. We find that the source region for the Aristarchus glasses contained high abundances of heat-producing elements, which most likely served as a thermal driver for the prolonged volcanic activity in this region of the Moon. Copyright 2009 by the American Geophysical Union.

Predicting stroke through genetic risk functions: the CHARGE Risk Score Project.

PubMed

Ibrahim-Verbaas, Carla A; Fornage, Myriam; Bis, Joshua C; Choi, Seung Hoan; Psaty, Bruce M; Meigs, James B; Rao, Madhu; Nalls, Mike; Fontes, Joao D; O'Donnell, Christopher J; Kathiresan, Sekar; Ehret, Georg B; Fox, Caroline S; Malik, Rainer; Dichgans, Martin; Schmidt, Helena; Lahti, Jari; Heckbert, Susan R; Lumley, Thomas; Rice, Kenneth; Rotter, Jerome I; Taylor, Kent D; Folsom, Aaron R; Boerwinkle, Eric; Rosamond, Wayne D; Shahar, Eyal; Gottesman, Rebecca F; Koudstaal, Peter J; Amin, Najaf; Wieberdink, Renske G; Dehghan, Abbas; Hofman, Albert; Uitterlinden, André G; Destefano, Anita L; Debette, Stephanie; Xue, Luting; Beiser, Alexa; Wolf, Philip A; Decarli, Charles; Ikram, M Arfan; Seshadri, Sudha; Mosley, Thomas H; Longstreth, W T; van Duijn, Cornelia M; Launer, Lenore J

2014-02-01

Beyond the Framingham Stroke Risk Score, prediction of future stroke may improve with a genetic risk score (GRS) based on single-nucleotide polymorphisms associated with stroke and its risk factors. The study includes 4 population-based cohorts with 2047 first incident strokes from 22,720 initially stroke-free European origin participants aged ≥55 years, who were followed for up to 20 years. GRSs were constructed with 324 single-nucleotide polymorphisms implicated in stroke and 9 risk factors. The association of the GRS to first incident stroke was tested using Cox regression; the GRS predictive properties were assessed with area under the curve statistics comparing the GRS with age and sex, Framingham Stroke Risk Score models, and reclassification statistics. These analyses were performed per cohort and in a meta-analysis of pooled data. Replication was sought in a case-control study of ischemic stroke. In the meta-analysis, adding the GRS to the Framingham Stroke Risk Score, age and sex model resulted in a significant improvement in discrimination (all stroke: Δjoint area under the curve=0.016, P=2.3×10(-6); ischemic stroke: Δjoint area under the curve=0.021, P=3.7×10(-7)), although the overall area under the curve remained low. In all the studies, there was a highly significantly improved net reclassification index (P<10(-4)). The single-nucleotide polymorphisms associated with stroke and its risk factors result only in a small improvement in prediction of future stroke compared with the classical epidemiological risk factors for stroke.

Additive influence of genetic predisposition and conventional risk factors in the incidence of coronary heart disease: a population-based study in Greece

USDA-ARS?s Scientific Manuscript database

An additive genetic risk score (GRS) for coronary heart disease (CHD) has previously been associated with incident CHD in the population-based Greek European Prospective Investigation into Cancer and nutrition (EPIC) cohort. In this study, we explore GRS-‘environment’ joint actions on CHD for severa...

Changing Characteristics of Jupiter's Little Red Spot

NASA Technical Reports Server (NTRS)

Cheng, A. F.; Simon-Miller, A. A.; Weaver, H. A.; Baines, K. H.; Orton, G. S.; Yanamandra-FIsher, P. A.; Mousis, O.; Pantin, E.; Vanzi, L.; Fletcher, L. N.;

“I Always Felt I Had to Prove My Manhood”: Homosexuality, Masculinity, Gender Role Strain, and HIV Risk Among Young Black Men Who Have Sex With Men

PubMed Central

Bogart, Laura M.; Smith, Katherine C.; Malebranche, David J.; Ellen, Jonathan; Schuster, Mark A.

2015-01-01

Objectives. We explored gender role strain (GRS) arising from conflict between homosexuality and cultural conceptions of masculinity among young Black men who have sex with men (MSM). Methods. We conducted a categorical analysis (a qualitative, 3-stage, iterative analysis) of data from studies conducted in 2001 to 2006, which interviewed 35 men aged 18 to 24 years in 3 New York cities and Atlanta, Georgia. Results. Participants described rigid, often antihomosexual expectations of masculinity from their families, peers, and communities. Consistent with GRS, this conflict and pressure to conform to these expectations despite their homosexuality led to psychological distress, efforts to camouflage their homosexuality, and strategies to prove their masculinity. Participants believed this conflict and the associated experience of GRS might increase HIV risk through social isolation, poor self-esteem, reduced access to HIV prevention messages, and limited parental–family involvement in sexuality development and early sexual decision-making. Conclusions. Antihomosexual expectations of masculinity isolate young Black MSM during a developmental stage when interpersonal attachments are critical. GRS may influence sexual risk behavior and HIV risk and be an important target for HIV prevention. PMID:24832150

Spectral Comparison and Stability of Red Regions on Jupiter

NASA Technical Reports Server (NTRS)

Simon, A. A.; Carlson, R. W.; Sanchez-Lavega, A.

2013-01-01

A study of absolute color on Jupiter from Hubble Space Telescope imaging data shows that the Great Red Spot (GRS) is not the reddest region of the planet. Rather, a transient red cyclone visible in 1995 and the North Equatorial Belt both show redder spectra than the GRS (i.e., more absorption at blue and green wavelengths). This cyclone is unique among vortices in that it is intensely colored yet low altitude, unlike the GRS. Temporal analysis shows that the darkest regions of the NEB are relative constant in color from 1995 to 2008, while the slope of the GRS core may vary slightly. Principal component analysis shows several spectral components are needed, in agreement with past work, and further highlights the differences between regions. These color differences may be indicative of the same chromophore(s) under different conditions, such as mixing with white clouds, longer UV irradiation at higher altitude, and thermal processing, or may indicate abundance variations in colored compounds. A single compound does not fit the spectrum of any region well and mixes of multiple compounds including NH4SH, photolyzed NH3, hydrocarbons, and possibly P4, are likely needed to fully match each spectrum.

Evidence for Infrared-faint Radio Sources as z > 1 Radio-loud Active Galactic Nuclei

NASA Astrophysics Data System (ADS)

Huynh, Minh T.; Norris, Ray P.; Siana, Brian; Middelberg, Enno

2010-02-01

Infrared-Faint Radio Sources (IFRSs) are a class of radio objects found in the Australia Telescope Large Area Survey which have no observable mid-infrared counterpart in the Spitzer Wide-area Infrared Extragalactic (SWIRE) survey. The extended Chandra Deep Field South now has even deeper Spitzer imaging (3.6-70 μm) from a number of Legacy surveys. We report the detections of two IFRS sources in IRAC images. The non-detection of two other IFRSs allows us to constrain the source type. Detailed modeling of the spectral energy distribution of these objects shows that they are consistent with high-redshift (z >~ 1) active galactic nuclei.

EVIDENCE FOR INFRARED-FAINT RADIO SOURCES AS z > 1 RADIO-LOUD ACTIVE GALACTIC NUCLEI

DOE Office of Scientific and Technical Information (OSTI.GOV)

Huynh, Minh T.; Norris, Ray P.; Siana, Brian

2010-02-10

Infrared-Faint Radio Sources (IFRSs) are a class of radio objects found in the Australia Telescope Large Area Survey which have no observable mid-infrared counterpart in the Spitzer Wide-area Infrared Extragalactic (SWIRE) survey. The extended Chandra Deep Field South now has even deeper Spitzer imaging (3.6-70 {mu}m) from a number of Legacy surveys. We report the detections of two IFRS sources in IRAC images. The non-detection of two other IFRSs allows us to constrain the source type. Detailed modeling of the spectral energy distribution of these objects shows that they are consistent with high-redshift (z {approx}> 1) active galactic nuclei.

A Clustered Extragalactic Foreground Model for the EoR

NASA Astrophysics Data System (ADS)

Murray, S. G.; Trott, C. M.; Jordan, C. H.

2018-05-01

We review an improved statistical model of extra-galactic point-source foregrounds first introduced in Murray et al. (2017), in the context of the Epoch of Reionization. This model extends the instrumentally-convolved foreground covariance used in inverse-covariance foreground mitigation schemes, by considering the cosmological clustering of the sources. In this short work, we show that over scales of k ~ (0.6, 40.)hMpc-1, ignoring source clustering is a valid approximation. This is in contrast to Murray et al. (2017), who found a possibility of false detection if the clustering was ignored. The dominant cause for this change is the introduction of a Galactic synchrotron component which shadows the clustering of sources.

Rocket ultraviolet imagery of the Andromeda galaxy

NASA Technical Reports Server (NTRS)

Carruthers, G. R.; Opal, C. B.; Heckathorn, H. M.

1978-01-01

Far-UV electrographic imagery of M31 is presented which was obtained during a sounding-rocket flight with an electrographic Schmidt camera sensitive in the wavelength range from 1230 to 2000 A. The resolution in the imagery is such that 50% of the energy from a point source is confined within a circle 40 arcsec in radius. Two conspicuous features are observed in the UV image of M31: one corresponding to a bright association (NGC 206) in the SW region of the disk and one centered on the galactic nucleus. Indications of the general spiral-arm structure are also evident. Absolute photometry and brightness distributions are obtained for the observed features, and both the central region and NGC 206 are shown to be diffuse sources. It is found that the brightness distribution of the central region is a flat ellipse with its major axis closely aligned with the major axis of the galaxy, which favors a source model consisting of young early-type stars close to the galactic plane and constitutes strong evidence against a nonthermal point source at the galactic center.

Thousands of Stellar SiO masers in the Galactic center: The Bulge Asymmetries and Dynamic Evolution (BAaDE) survey

NASA Astrophysics Data System (ADS)

Sjouwerman, Loránt O.; Pihlström, Ylva M.; Rich, R. Michael; Morris, Mark R.; Claussen, Mark J.

2017-01-01

A radio survey of red giant SiO sources in the inner Galaxy and bulge is not hindered by extinction. Accurate stellar velocities (<1 km/s) are obtained with minimal observing time (<1 min) per source. Detecting over 20,000 SiO maser sources yields data comparable to optical surveys with the additional strength of a much more thorough coverage of the highly obscured inner Galaxy. Modeling of such a large sample would reveal dynamical structures and minority populations; the velocity structure can be compared to kinematic structures seen in molecular gas, complex orbit structure in the bar, or stellar streams resulting from recently infallen systems. Our Bulge Asymmetries and Dynamic Evolution (BAaDE) survey yields bright SiO masers suitable for follow-up Galactic orbit and parallax determination using VLBI. Here we outline our early VLA observations at 43 GHz in the northern bulge and Galactic plane (0

Progress report on the Heavy Ions in Space (HIIS) experiment

NASA Technical Reports Server (NTRS)

Adams, James H., Jr.; Beahm, Lorraine P.; Boberg, Paul R.; Tylka, Allan J.

1993-01-01

One of the objectives of the Heavy Ions In Space (HIIS) experiment is to investigate heavy ions which appear at Long Duration Exposure Facility (LDEF) below the geomagnetic cutoff for fully-ionized galactic cosmic rays. Possible sources of such 'below-cutoff' particles are partially-ionized solar energetic particles, the anomalous component of cosmic rays, and magnetospherically-trapped particles. In recent years, there have also been reports of below-cutoff ions which do not appear to be from any known source. Although most of these observations are based on only a handful of ions, they have led to speculation about 'partially-ionized galactic cosmic rays' and 'near-by cosmic ray sources'. The collecting power of HIIS is order of magnitude larger than that of the instruments which reported these results, so HIIS should be able to confirm these observations and perhaps discover the source of these particles. Preliminary results on below-cutoff heavy-ions are reported. Observations to possible known sources of such ions are compared. A second objective of the HIIS experiment is to measure the elemental composition of ultraheavy galactic cosmic rays, beginning in the tin-barium region of the periodic table. A report on the status of this analysis is presented.

Recent Results on SNRs and PWNe from the Fermi Large Area Telescope

NASA Technical Reports Server (NTRS)

Hays, Elizabeth

2010-01-01

Topics include: Fermi LAT Collaboration groups; galactic results from LAT; a GeV, wide-field instrument; the 1FGL catalog, the Fermi LAT 1FGL source catalog, unidentified gamma-ray sources; variability in 1FGL sources; curvature in 1FGL sources; spectral-variability classification; pulsars and their wind nebulae; gamma-ray pulsars and MSPs; GeV PWN search; Crab pulsar and nebula; Vela X nebular of Vela pulsar; MSH 15-52; supernova remnants, resolved GeV sources, galactic transients, LAT unassociated transient detections; gamma rays from a nova; V407 Cyngi - a symbiotic nova; V407 Cygni: a variable star; and March 11 - a nova. Summary slides include pulsars everywhere, blazars, LAT as an electron detector, cosmic ray spectrum, the Large Area Telescope, the Fermi Observatory, LAT sensitivity with time, candidate gamma-ray events, on-orbit energy calibration and rate, a 1 year sky map, LAT automated science processing, reported GeV flares, early activity and spectacular flare, gamma-ray transients near the galactic plane , two early unassociated transients, counter part search - Fermi J0910-5404; counterpart search 3EG J0903-3531, and a new LAT transient - J1057-6027.

Universal energy spectrum from point sources

NASA Technical Reports Server (NTRS)

Tomozawa, Yukio

1992-01-01

The suggestion is made that the energy spectrum from point sources such as galactic black hole candidates (GBHC) and active galactic nuclei (AGN) is universal on the average, irrespective of the species of the emitted particles, photons, nucleons, or others. The similarity between the observed energy spectra of cosmic rays, gamma-rays, and X-rays is discussed. In other words, the existing data for gamma-rays and X-rays seem to support the prediction. The expected data from the Gamma Ray Observatory are to provide a further test.

The spectra of ten galactic X-ray sources in the southern sky

NASA Technical Reports Server (NTRS)

Cruddace, R.; Bowyer, S.; Lampton, M.; Mack, J. E., Jr.; Margon, B.

1971-01-01

Data on ten galactic X-ray sources were obtained during a rocket flight from Brazil in June 1969. Detailed spectra of these sources have been compared with bremsstrahlung, black body, and power law models, each including interstellar absorption. Six of the sources were fitted well by one or more of these models. In only one case were the data sufficient to distinguish the best model. Three of the sources were not fitted by any of the models, which suggests that more complex emission mechanisms are applicable. A comparison of our results with those of previous investigations provides evidence that five of the sources vary in intensity by a factor of 2 or more, and that three have variable spectra. New or substantially improved positions have been derived for four of the sources observed.

THE NuSTAR Hard X-Ray Survey of the Norma Arm Region

NASA Technical Reports Server (NTRS)

Fornasini, Francesca M.; Tomsick, John A.; Hong, Jaesub; Gotthelf, Eric V.; Bauer, Franz; Rahoui, Farid; Stern, Daniel K.; Bodaghee, Arash; Chiu, Jeng-Lun; Clavel, Maïca;

The NuSTAR Hard X-Ray Survey of the Norma Arm Region

DOE PAGES

Fornasini, Francesca M.; Tomsick, John A.; Hong, JaeSub; ...

2017-04-06

We present a catalog of hard X-ray sources in a square-degree region surveyed by NuSTAR in the direction of the Norma spiral arm. This survey has a total exposure time of 1.7 Ms, and typical and maximum exposure depths of 50 ks and 1 Ms, respectively. In the area of deepest coverage, sensitivity limits of 5 x 10 -14 and 4 x 10-14 erg s -1 cm -2 in the 3–10 and 10–20 keV bands, respectively, are reached. Twenty-eight sources are firmly detected and ten are detected with low significance; eight of the 38 sources are expected to be activemore » galactic nuclei. The three brightest sources were previously identified as a low-mass X-ray binary, high-mass X-ray binary, and pulsar wind nebula. Based on their X-ray properties and multi-wavelength counterparts, we identify the likely nature of the other sources as two colliding wind binaries, three pulsar wind nebulae, a black hole binary, and a plurality of cataclysmic variables (CVs). The CV candidates in the Norma region have plasma temperatures of ≈10–20 keV, consistent with the Galactic Ridge X-ray emission spectrum but lower than temperatures of CVs near the Galactic Center. This temperature difference may indicate that the Norma region has a lower fraction of intermediate polars relative to other types of CVs compared to the Galactic Center. The NuSTAR logN-logS distribution in the 10–20 keV band is consistent with the distribution measured by Chandra at 2–10 keV if the average source spectrum is assumed to be a thermal model with kT ≈ 15 keV, as observed for the CV candidates.« less

Observation of Galactic Sources of Very High Energy γ-RAYS with the Magic Telescope

NASA Astrophysics Data System (ADS)

Bartko, H.

The MAGIC telescope with its 17m diameter mirror is today the largest operating single-dish Imaging Air Cherenkov Telescope (IACT). It is located on the Canary Island La Palma, at an altitude of 2200 m above sea level, as part of the Roque de los Muchachos European Northern Observatory. The MAGIC telescope detects celestial very high energy γ-radiation in the energy band between about 50 GeV and 10 TeV. Since the autumn of 2004 MAGIC has been taking data routinely, observing various objects, like supernova remnants (SNRs), γ-ray binaries, Pulsars, Active Galactic Nuclei (AGN) and Gamma-ray Bursts (GRB). We briefly describe the observational strategy, the procedure implemented for the data analysis, and discuss the results of observations of Galactic Sources.

'Damn that's bright!' - why ignoring the Eddington limit is so much fun

NASA Astrophysics Data System (ADS)

Middleton, M.

2017-10-01

Decades of studying compact objects has led to an explosion in our understanding, yet some puzzles remain unanswered. Whilst the vast majority of Galactic black hole binary systems accrete at a rate below their classical Eddington limit, several appear to exceed it and whilst doing so show the most dramatic of phenomenology including the most powerful ballistic jet events and equatorial outflows. Standing alone as the most extreme example is the Galactic microquasar SS433. Long considered by some to be a Galactic `ultraluminous X-ray source', it is literally shrouded in mystery thanks to an optically thick wind obscuring the central regions. I will discuss these systems and new work which sheds light on SS433 and how it might fit into the growing picture of super-critically accreting sources.

Documentation for the machine-readable version of the catalog of galactic O type stars

NASA Technical Reports Server (NTRS)

Warren, W. H., Jr.

1982-01-01

The Catalog of Galactic O-Type Stars (Garmany, Conti and Chiosi 1982), a compilation from the literature of all O-type stars for which spectral types, luminosity classes and UBV photometry exist, contains 765 stars, for each of which designation (HD, DM, etc.), spectral type, V, B-V, cluster membership, Galactic coordinates, and source references are given. Derived values of absolute visual and bolometric magnitudes, and distances are included. The source reference should be consulted for additional details concerning the derived quantities. This description of the machine-readable version of the catalog seeks to enable users to read and process the data with a minimum of guesswork. A copy of this document should be distributed with any machine readable version of the catalog.

Identification of a Population of X-Ray-Emitting Massive Stars in the Galactic Plane

DTIC Science & Technology

2011-02-01

The Advanced Satellite for Cosmology and Astrophysics (ASCA) surveyed the inner region of the Galactic plane, detecting 163 X-ray sources with...exhibit this profile. Given the current data this is all very speculative. We defer any definitive conclusions about the weak spectral features or

Probing the Interstellar Dust towards the Galactic Centre using X-ray Dust Scattering Halos

NASA Astrophysics Data System (ADS)

Jin, C.; Ponti, G.; Haberl, F.; Smith, R.

2017-10-01

Dust scattering creates an X-ray halo that contains abundant information about the interstellar dust along the source's line-of-sight (LOS), and is most prominent when the LOS nH is high. In this talk, I will present results from our latest study of a bright dust scattering halo around an eclipsing X-ray binary at 1.45 arcmin away from Sgr A*, namely AX J1745.6-2901. This study is based on a large set of XMM-Newton and Chandra observations, and is so-far the best dust scattering halo study of a X-ray transient in the Galactic centre (GC). I will show that the foreground dust of AX J1745.6-2901 can be decomposed into two major thick dust layers. One layer contains (66-81)% of the total LOS dust and is several kpc away from the source, and so is most likely to reside in the Galactic disc. The other layer is local to the source. I will also show that the dust scattering halo can cause the source spectrum to severely depend on the source extraction region. Such spectral bias can be corrected by our new Xspec model, which is likely to be applicable to Sgr A* and other GC sources as well.

On the Physical Environment in the Galactic Nuclei. Ph.D. Thesis - Maryland Univ.

NASA Technical Reports Server (NTRS)

Beall, J. H.

1979-01-01

Galactic nuclei and quasars emit radiation over the entire electromagnetic spectrum. This suggests that concurrent observations over a wide frequency range may provide useful information in determining appropriate models for the physical environment in which the radiation is produced. In conjunction with observations by the high energy spectrometer on OSO-8, four sources have been studied in this manner; the nucleus of the elliptical galaxy, Centaurus A (NGG 5128); the quasar, 30273; the Seyfert galaxy, NGC 4151 and the nucleus of the Milky Way (GCX). Concurrent observations are used to construct the composite spectra (from radio to X-ray) for Cen A and NGC 4151 while the composite spectra of 30273 and GCX are derived from the OSO-8 data and from other observers. A skymap technique used to analyze observations of the galactic center region yielded data consistent with a significant, hard X-ray source at the radio and infrared position of the nucleus of the Milky Way. A theoretical analysis of the temporal variability of the Cen A data is undertaken and its implications discussed. Similarities between the composite spectra of the observed sources suggest that radio-bright and radio-quiet quasars may represent the emission from galactic nuclei with elliptical and Seyfert-like morphologies, respectively.

Association of a Genetic Risk Score With Body Mass Index Across Different Birth Cohorts.

PubMed

Walter, Stefan; Mejía-Guevara, Iván; Estrada, Karol; Liu, Sze Y; Glymour, M Maria

2016-07-05

Many genetic variants are associated with body mass index (BMI). Associations may have changed with the 20th century obesity epidemic and may differ for black vs white individuals. Using birth cohort as an indicator for exposure to obesogenic environment, to evaluate whether genetic predisposition to higher BMI has a larger magnitude of association among adults from more recent birth cohorts, who were exposed to the obesity epidemic at younger ages. Observational study of 8788 adults in the US national Health and Retirement Study who were aged 50 years and older, born between 1900 and 1958, with as many as 12 BMI assessments from 1992 to 2014. A multilocus genetic risk score for BMI (GRS-BMI), calculated as the weighted sum of alleles of 29 single nucleotide polymorphisms associated with BMI, with weights equal to the published per-allele effects. The GRS-BMI represents how much each person's BMI is expected to differ, based on genetic background (with respect to these 29 loci), from the BMI of a sample member with median genetic risk. The median-centered GRS-BMI ranged from -1.68 to 2.01. BMI based on self-reported height and weight. GRS-BMI was significantly associated with BMI among white participants (n = 7482; mean age at first assessment, 59 years; 3373 [45%] were men; P <.001) and among black participants (n = 1306; mean age at first assessment, 57 years; 505 [39%] were men; P <.001) but accounted for 0.99% of variation in BMI among white participants and 1.37% among black participants. In multilevel models accounting for age, the magnitude of associations of GRS-BMI with BMI were larger for more recent birth cohorts. For example, among white participants, each unit higher GRS-BMI was associated with a difference in BMI of 1.37 (95% CI, 0.93 to 1.80) if born after 1943, and 0.17 (95% CI, -0.55 to 0.89) if born before 1924 (P = .006). For black participants, each unit higher GRS-BMI was associated with a difference in BMI of 3.70 (95% CI, 2.42 to 4.97) if born after 1943, and 1.44 (95% CI, -1.40 to 4.29) if born before 1924. For participants born between 1900 and 1958, the magnitude of association between BMI and a genetic risk score for BMI was larger among persons born in later cohorts. This suggests that associations of known genetic variants with BMI may be modified by obesogenic environments.

Analyzing γ rays of the Galactic Center with deep learning

NASA Astrophysics Data System (ADS)

Caron, Sascha; Gómez-Vargas, Germán A.; Hendriks, Luc; Ruiz de Austri, Roberto

2018-05-01

We present the application of convolutional neural networks to a particular problem in gamma ray astronomy. Explicitly, we use this method to investigate the origin of an excess emission of GeV γ rays in the direction of the Galactic Center, reported by several groups by analyzing Fermi-LAT data. Interpretations of this excess include γ rays created by the annihilation of dark matter particles and γ rays originating from a collection of unresolved point sources, such as millisecond pulsars. We train and test convolutional neural networks with simulated Fermi-LAT images based on point and diffuse emission models of the Galactic Center tuned to measured γ ray data. Our new method allows precise measurements of the contribution and properties of an unresolved population of γ ray point sources in the interstellar diffuse emission model. The current model predicts the fraction of unresolved point sources with an error of up to 10% and this is expected to decrease with future work.

Searching for High Proper Motion Sources Towards the Galactic Center using Convolution Neural Networks

NASA Astrophysics Data System (ADS)

Giongo Fernandes, Alexandre; Benjamin, Robert A.; Babler, Brian

2018-01-01

Two sets of infrared images of the Galactic Center region (|L|< 1 degree and |B| < 0.75 degrees) taken by the Spitzer Space Telescope in IRAC 3.6 micron and 4.5 micron bands are searched for high proper motion objects (> 100 mas/year). The two image sets come from GALCEN observations in 2005 and GLIMPSE proper observations in 2015 with matched observation modes. We use three different methods to search for these objects in extremely crowded fields: (1) comparing matched point source lists, (2) crowd sourcing by several college introductory astronomy classes in the state of Wisconsin (700 volunteers), and (3) convolutional neural networks trained using objects from the previous two methods. Before our search six high proper objects were known, four of which were found by the VVV near-infrared Galactic plane survey. We compare and describe our methods for this search, and present a preliminary catalog of high proper motions objects.

The gamma-ray luminosity function of millisecond pulsars and implications for the GeV excess

DOE PAGES

Hooper, Dan; Mohlabeng, Gopolang

2016-03-29

It has been proposed that a large population of unresolved millisecond pulsars (MSPs) could potentially account for the excess of GeV-scale gamma-rays observed from the region surrounding the Galactic Center. The viability of this scenario depends critically on the gamma-ray luminosity function of this source population, which determines how many MSPs Fermi should have already detected as resolved point sources. In this paper, we revisit the gamma-ray luminosity function of MSPs, without relying on uncertain distance measurements. Our determination, based on a comparison of models with the observed characteristics of the MSP population, suggests that Fermi should have already detectedmore » a significant number of sources associated with such a hypothesized Inner Galaxy population. As a result, we cannot rule out a scenario in which the MSPs residing near the Galactic Center are systematically less luminous than those present in the Galactic Plane or within globular clusters.« less

Development and content validation of performance assessments for endoscopic third ventriculostomy.

PubMed

Breimer, Gerben E; Haji, Faizal A; Hoving, Eelco W; Drake, James M

2015-08-01

This study aims to develop and establish the content validity of multiple expert rating instruments to assess performance in endoscopic third ventriculostomy (ETV), collectively called the Neuro-Endoscopic Ventriculostomy Assessment Tool (NEVAT). The important aspects of ETV were identified through a review of current literature, ETV videos, and discussion with neurosurgeons, fellows, and residents. Three assessment measures were subsequently developed: a procedure-specific checklist (CL), a CL of surgical errors, and a global rating scale (GRS). Neurosurgeons from various countries, all identified as experts in ETV, were then invited to participate in a modified Delphi survey to establish the content validity of these instruments. In each Delphi round, experts rated their agreement including each procedural step, error, and GRS item in the respective instruments on a 5-point Likert scale. Seventeen experts agreed to participate in the study and completed all Delphi rounds. After item generation, a total of 27 procedural CL items, 26 error CL items, and 9 GRS items were posed to Delphi panelists for rating. An additional 17 procedural CL items, 12 error CL items, and 1 GRS item were added by panelists. After three rounds, strong consensus (>80% agreement) was achieved on 35 procedural CL items, 29 error CL items, and 10 GRS items. Moderate consensus (50-80% agreement) was achieved on an additional 7 procedural CL items and 1 error CL item. The final procedural and error checklist contained 42 and 30 items, respectively (divided into setup, exposure, navigation, ventriculostomy, and closure). The final GRS contained 10 items. We have established the content validity of three ETV assessment measures by iterative consensus of an international expert panel. Each measure provides unique assessment information and thus can be used individually or in combination, depending on the characteristics of the learner and the purpose of the assessment. These instruments must now be evaluated in both the simulated and operative settings, to determine their construct validity and reliability. Ultimately, the measures contained in the NEVAT may prove suitable for formative assessment during ETV training and potentially as summative assessment measures during certification.

Development of a Gamma-Ray Spectrometer for Korean Pathfinder Lunar Orbiter

NASA Astrophysics Data System (ADS)

Kim, Kyeong Ja; Park, Junghun; Choi, Yire; Lee, Sungsoon; Yeon, Youngkwang; Yi, Eung Seok; Jeong, Meeyoung; Sun, Changwan; van Gasselt, Stephan; Lee, K. B.; Kim, Yongkwon; Min, Kyungwook; Kang, Kyungin; Cho, Jinyeon; Park, Kookjin; Hasebe, Nobuyuki; Elphic, Richard; Englert, Peter; Gasnault, Olivier; Lim, Lucy; Shibamura, Eido; GRS Team

2016-10-01

Korea is preparing for a lunar orbiter mission (KPLO) to be developed in no later than 2018. Onboard the spacecraft is a gamma ray spectrometer (KLGRS) allowing to collect low energy gamma-ray signals in order to detect elements by either X-ray fluorescence or by natural radioactive decay in the low as well as higher energy regions of up to 10 MeV. Scientific objectives include lunar resources (water and volatile measurements, rare earth elements and precious metals, energy resources, major elemental distributions for prospective in-situ utilizations), investigation of the lunar geology and studies of the lunar environment (mapping of the global radiation environment from keV to 10 MeV, high energy cosmic ray flux using the plastic scintillator).The Gamma-Ray Spectrometer (GRS) system is a compact low-weight instrument for the chemical analysis of lunar surface materials within a gamma-ray energy range from 10s keV to 10 MeV. The main LaBr3 detector is surrounded by an anti-coincidence counting module of BGO/PS scintillators to reduce both low gamma-ray background from the spacecraft and housing materials and high energy gamma-ray background from cosmic rays. The GRS system will determine the elemental compositions of the near surface of the Moon.The GRS system is a recently developed gamma-ray scintillation based detector which can be used as a replacement for the HPGe GRS sensor with the advantage of being able to operate at a wide range of temperatures with remarkable energy resolution. LaBr3 also has a high photoelectron yield, fast scintillation response, good linearity and thermal stability. With these major advantages, the LaBr3 GRS system will allow us to investigate scientific objectives and assess important research questions on lunar geology and resource exploration.The GRS investigation will help to assess open questions related to the spatial distribution and origin of the elements on the lunar surface and will contribute to unravel geological surface evolution and elemental distributions of potential lunar resources.

Gamma-ray Monitoring of Active Galactic Nuclei with HAWC

NASA Astrophysics Data System (ADS)

Lauer, Robert; HAWC Collaboration

2016-03-01

Active Galactic Nuclei (AGN) are extra-galactic sources that can exhibit extreme flux variability over a wide range of wavelengths. TeV gamma rays have been observed from about 60 AGN and can help to diagnose emission models and to study cosmic features like extra-galactic background light or inter-galactic magnetic fields. The High Altitude Water Cherenkov (HAWC) observatory is a new extensive air shower array that can complement the pointed TeV observations of imaging air Cherenkov telescopes. HAWC is optimized for studying gamma rays with energies between 100 GeV and 100 TeV and has an instantaneous field of view of ~2 sr and a duty cycle >95% that allow us to scan 2/3 of the sky every day. By performing an unbiased monitoring of TeV emissions of AGN over most of the northern and part of the southern sky, HAWC can provide crucial information and trigger follow-up observations in collaborations with pointed TeV instruments. Furthermore, HAWC coverage of AGN is complementary to that provided by the Fermi satellite at lower energies. In this contribution, we will present HAWC flux light curves of TeV gamma rays from various sources, notably the bright AGN Markarian 421 and Markarian 501, and highlight recent results from multi-wavelengths and multi-instrument studies.

Gamma-ray and X-ray emission from the Galactic centre: hints on the nuclear star cluster formation history

NASA Astrophysics Data System (ADS)

Arca-Sedda, Manuel; Kocsis, Bence; Brandt, Timothy D.

2018-06-01

The Milky Way centre exhibits an intense flux in the gamma and X-ray bands, whose origin is partly ascribed to the possible presence of a large population of millisecond pulsars (MSPs) and cataclysmic variables (CVs), respectively. However, the number of sources required to generate such an excess is much larger than what is expected from in situ star formation and evolution, opening a series of questions about the formation history of the Galactic nucleus. In this paper we make use of direct N-body simulations to investigate whether these sources could have been brought to the Galactic centre by a population of star clusters that underwent orbital decay and formed the Galactic nuclear star cluster (NSC). Our results suggest that the gamma ray emission is compatible with a population of MSPs that were mass segregated in their parent clusters, while the X-ray emission is consistent with a population of CVs born via dynamical interactions in dense star clusters. Combining observations with our modelling, we explore how the observed γ ray flux can be related to different NSC formation scenarios. Finally, we show that the high-energy emission coming from the galactic central regions can be used to detect black holes heavier than 105M⊙ in nearby dwarf galaxies.

Development of the Model of Galactic Interstellar Emission for Standard Point-Source Analysis of Fermi Large Area Telescope Data

DOE PAGES

Acero, F.

2016-04-22

Most of the celestial γ rays detected by the Large Area Telescope (LAT) aboard the Fermi Gamma-ray Space Telescope originate from the interstellar medium when energetic cosmic rays interact with interstellar nucleons and photons. Conventional point and extended source studies rely on the modeling of this diffuse emission for accurate characterization. We describe here the development of the Galactic Interstellar Emission Model (GIEM) that is the standard adopted by the LAT Collaboration and is publicly available. The model is based on a linear combination of maps for interstellar gas column density in Galactocentric annuli and for the inverse Compton emissionmore » produced in the Galaxy. We also include in the GIEM large-scale structures like Loop I and the Fermi bubbles. The measured gas emissivity spectra con rm that the cosmic-ray proton density decreases with Galactocentric distance beyond 5 kpc from the Galactic Center. The measurements also suggest a softening of the proton spectrum with Galactocentric distance. We observe that the Fermi bubbles have boundaries with a shape similar to a catenary at latitudes below 20° and we observe an enhanced emission toward their base extending in the North and South Galactic direction and located within ~4° of the Galactic Center.« less

The Observed Galactic Annihilation Line: Possible Signature of Accreting Small Mass Black Holes in the Galactic Center

NASA Technical Reports Server (NTRS)

Titarchuk, Lev; Chardonnet, Pascal

2006-01-01

Various balloon and satellite observatories have revealed what appears to be an extended source of 0.511 MeV annihilation radiation with flux of approx. 10(exp -3) photons/sq cm/s centered on the Galactic Center. Positrons from radioactive products of stellar explosions can account for a significant fraction of the emission. We discuss an additional source for this emission: namely e(+)e(-) pairs produced when X-rays generated from the approx. 2.6 x 10(exp 6) solar mass Galactic Center Black Hole interact with approx. 10 MeV temperature blackbody emission from 10(exp 17) g black holes within 10(exp 14-l5) cm of the center. The number of such Small Mass Black Holes (SMMBHs) can account for the production of the 10(exp 42) e(+)/s that produces the observed annihilation in the inner Galaxy when transport effects are taken into account. We consider the possibility for confirming the presence of these SMMBHs in the Galactic Center region with future generations of gamma-ray instruments if a blackbody like emission of approx. 10 MeV temperature would be detected by them. Small Mass Black Hole can be a potential candidate for dark (invisible) matter hal

SMM detection of diffuse Galactic 511 keV annihilation radiation

NASA Technical Reports Server (NTRS)

Share, G. H.; Kinzer, R. L.; Kurfess, J. D.; Messina, D. C.; Purcell, W. R.

1988-01-01

Observations of the 511 keV annihilation line from the vicinity of the Galactic center from October to February for 1980/1981, 1981/1982, 1982/1983, 1984/1985, and 1985/1986 are presented. The measurements were made with the gamma-ray spectrometer on the SMM. The design of the instrument and some of its properties used in the analysis are described, and the methods used for accumulating, fitting, and analyzing the data are outlined. It is shown how the Galactic 511 keV line was separated from the intense and variable background observed in orbit. The SMM observations are compared with previous measurements of annihilation radiation from the Galactic center region, and the astrophysical implications are discussed. It is argued that most of the measurements made to date suggest the presence of an extended Galactic source of annihilation radiation.

Search for Gamma-Ray Emission from Galactic Novae using Fermi-LAT Pass 8

NASA Astrophysics Data System (ADS)

Buson, Sara; Franckowiak, Anna; Cheung, Teddy; Jean, Pierre; Fermi-LAT Collaboration

2016-01-01

Recently Galactic novae have been identified as a new class of GeV gamma-ray emitters, with 6 detected so far with the Fermi Large Area Telescope (Fermi-LAT) data. Based on optical observations we have compiled a catalog of ~70 Galactic novae, which peak (in optical) during the operations of the Fermi mission. Based on the properties of known gamma-ray novae we developed a search procedure that we apply to all novae in the catalog to detect these slow transient sources or set flux upper limits using the Fermi-LAT Pass 8 data set. This is the first time a large sample of Galactic novae has been uniformly studied.

A discussion of the H-alpha filamentary nebulae and galactic structure in the Cygnus region

NASA Technical Reports Server (NTRS)

Matthews, T. A.; Simonson, S. C., III

1971-01-01

From observation of the galactic structure in Cygnus, the system of filamentary nebulae was found to lie at a distance of roughly 1.5 kpc, in the same region as about half the thermal radio sources in Cygnus X, the supernova remnant near gamma Cygni, and the association Cygnus OB2, in the direction of which the X-ray source Cygnus XR-3 is observed. The source of excitation was probably the pulse of radiation from a supernova explosion, as proposed in the case of Gum nebula. However continuing excitation by early stars in the region of Cygnus X cannot be excluded.

Multiwavelength Challenges in the Fermi Era

NASA Technical Reports Server (NTRS)

Thompson, D. J.

2010-01-01

The gamma-ray surveys of the sky by AGILE and the Fermi Gamma-ray Space Telescope offer both opportunities and challenges for multiwavelength and multi-messenger studies. Gamma-ray bursts, pulsars, binary sources, flaring Active Galactic Nuclei, and Galactic transient sources are all phenomena that can best be studied with a wide variety of instruments simultaneously or contemporaneously. From the gamma-ray side, a principal challenge is the latency from the time of an astrophysical event to the recognition of this event in the data. Obtaining quick and complete multiwavelength coverage of gamma-ray sources of interest can be difficult both in terms of logistics and in terms of generating scientific interest.

Constraining the Milky Way's Faint HMXB Population Using Archival Data

NASA Astrophysics Data System (ADS)

Tomsick, John

2017-09-01

In the first 40 months of sensitive hard X-ray observations with the Nuclear Spectroscopic Telescope Array, nearly 500 sources have been detected serendipitously. While the effort to determine the nature of these sources has been very successful at high Galactic latitudes, identifications close to the Galactic plane have been more difficult because of source crowding and optical extinction. Only six 8-24 keV sources within 5 deg of the plane have been classified, and two of them are High-Mass X-ray Binaries (HMXBs), leaving open the possibility of a large population of faint HMXBs. We propose an archival study of 13 unclassified sources, including obtaining subarcsecond positions, which, along with joint near-IR imaging, will be used to find counterparts and determine their nature.

Status Of The Swift Burst Alert Telescope Hard X-ray Transient Monitor

NASA Astrophysics Data System (ADS)

Krimm, Hans A.; Barthelmy, S. D.; Baumgartner, W. H.; Cummings, J.; Fenimore, E.; Gehrels, N.; Markwardt, C. B.; Palmer, D.; Sakamoto, T.; Skinner, G. K.; Stamatikos, M.; Tueller, J.

2010-01-01

The Swift Burst Alert Telescope hard X-ray transient monitor has been operating since October 1, 2006. More than 700 sources are tracked on a daily basis and light curves are produced and made available to the public on two time scales: a single Swift pointing (approximately 20 minutes) and the weighted average for each day. Of the monitored sources, approximately 33 are detected daily and another 100 have had one or more outburst during the Swift mission. The monitor is also sensitive to the detection of previously undiscovered sources and we have reported the discovery of four galactic sources and one source in the Large Magellanic Cloud. Follow-up target of opportunity observations with Swift and the Rossi X-Ray Timing Explorer have revealed that three of these new sources are pulsars and two are black hole candidates. In addition, the monitor has led to the announcement of significant outbursts from 24 different galactic and extra-galactic sources, many of which have had follow-up Swift XRT, UVOT and ground based multi-wavelength observations. The transient monitor web pages currently receive an average of 21 visits per day. We will report on the most important results from the transient monitor and also on detection and exposure statistics and outline recent and planned improvements to the monitor. The transient monitor web page is http://swift.gsfc.nasa.gov/docs/swift/results/transients/.

A Search for New Galactic Magnetars in Archival Chandra and XMM-Newton Observations

NASA Astrophysics Data System (ADS)

Muno, M. P.; Gaensler, B. M.; Nechita, A.; Miller, J. M.; Slane, P. O.

2008-06-01

We present constraints on the number of Galactic magnetars, which we have established by searching for sources with periodic variability in 506 archival Chandra observations and 441 archival XMM-Newton observations of the Galactic plane (| b| < 5°). Our search revealed four sources with periodic variability on timescales of 200-5000 s, all of which are probably accreting white dwarfs. We identify 7 of 12 known Galactic magnetars, but find no new examples with periods between 5 and 20 s. We convert this nondetection into limits on the total number of Galactic magnetars by computing the fraction of the young Galactic stellar population that our survey covered. We find that easily detectable magnetars, modeled after persistent anomalous X-ray pulsars (e.g., with LX = 1035 ergs s-1 [0.5-10.0 keV] and Arms = 12% ), could have been identified in ≈5% of the Galactic spiral arms by mass. If we assume that three previously known examples randomly fall within our survey, then there are 59+ 92-32 in the Galaxy. Barely detectable magnetars (LX = 3 × 1033 ergs s-1 and Arms = 15% ) could have been identified throughout ≈0.4% of the spiral arms. The lack of new examples implies that <540 exist in the Galaxy (90% confidence). Similar constraints are found by considering the detectability of transient magnetars in outburst. For assumed lifetimes of 104 yr, the birth rate of magnetars is between 0.003 and 0.06 yr-1. Therefore, the birth rate of magnetars is at least 10% of that for normal radio pulsars, and could exceed that value, unless transient magnetars are active for gtrsim105 yr.

Association of genetic predisposition to obesity with type 2 diabetes risk in Han Chinese individuals.

PubMed

Zhu, Jingwen; Zong, Geng; Lu, Ling; Gan, Wei; Ji, Linong; Hu, Renming; Ye, Xingwang; Sun, Liang; Loos, Ruth J F; Li, Huaixing; Lin, Xu

2014-09-01

Obesity is a major risk factor for type 2 diabetes, but little is known about the contribution of BMI-associated loci to type 2 diabetes risk in East Asian populations. In this study, 30 known BMI-associated variants and a genetic risk score (GRS) calculated by summing the BMI-increasing alleles of these variants were tested for associations with type 2 diabetes and related glycaemic traits in 1,873 cases of type 2 diabetes and 1,839 controls in Han Chinese individuals. Logistic and linear regression analyses were performed to determine the association with type 2 diabetes risk or related glycaemic traits, respectively, under an additive model with or without adjustment for BMI. The GRS was significantly associated with increased BMI (β [SE] 0.070 [0.016]; p = 1.33 × 0(-5)) in the overall population. Each additional BMI-increasing allele in the GRS increased type 2 diabetes risk by 1.029-fold (95% CI 1.008, 1.050; p = 0.0056) without adjustment for BMI, and the association was slightly attenuated after adjustment for BMI (OR 1.022; 95% CI 1.002, 1.043; p = 0.035). In non-diabetic controls, the GRS was also associated with HOMA of beta cell function (HOMA-B) with adjustment for BMI (β [SE] -0.876 [0.345]; p = 0.011). Notably, the association of GRS with type 2 diabetes was abolished after adjusting for HOMA-B (OR 1.012; 95% CI 0.986, 1.039; p = 0.380). Our results suggested that genetic predisposition to obesity leads to increased risk of type 2 diabetes, independent of BMI and partly through impaired beta cell function.

Validity Evidence for the Neuro-Endoscopic Ventriculostomy Assessment Tool (NEVAT).

PubMed

Breimer, Gerben E; Haji, Faizal A; Cinalli, Giuseppe; Hoving, Eelco W; Drake, James M

2017-02-01

Growing demand for transparent and standardized methods for evaluating surgical competence prompted the construction of the Neuro-Endoscopic Ventriculostomy Assessment Tool (NEVAT). To provide validity evidence of the NEVAT by reporting on the tool's internal structure and its relationship with surgical expertise during simulation-based training. The NEVAT was used to assess performance of trainees and faculty at an international neuroendoscopy workshop. All participants performed an endoscopic third ventriculostomy (ETV) on a synthetic simulator. Participants were simultaneously scored by 2 raters using the NEVAT procedural checklist and global rating scale (GRS). Evidence of internal structure was collected by calculating interrater reliability and internal consistency of raters' scores. Evidence of relationships with other variables was collected by comparing the ETV performance of experts, experienced trainees, and novices using Jonckheere's test (evidence of construct validity). Thirteen experts, 11 experienced trainees, and 10 novices participated. The interrater reliability by the intraclass correlation coefficient for the checklist and GRS was 0.82 and 0.94, respectively. Internal consistency (Cronbach's α) for the checklist and the GRS was 0.74 and 0.97, respectively. Median scores with interquartile range on the checklist and GRS for novices, experienced trainees, and experts were 0.69 (0.58-0.86), 0.85 (0.63-0.89), and 0.85 (0.81-0.91) and 3.1 (2.5-3.8), 3.7 (2.2-4.3) and 4.6 (4.4-4.9), respectively. Jonckheere's test showed that the median checklist and GRS score increased with performer expertise ( P = .04 and .002, respectively). This study provides validity evidence for the NEVAT to support its use as a standardized method of evaluating neuroendoscopic competence during simulation-based training. Copyright © 2016 by the Congress of Neurological Surgeons

Assessment of Myocardial Infarct Size by Three-Dimensional and Two-Dimensional Speckle Tracking Echocardiography: A Comparative Study to Single Photon Emission Computed Tomography.

PubMed

Wang, Qiushuang; Huang, Dangsheng; Zhang, Liwei; Shen, Dong; Ouyang, Qiaohong; Duan, Zhongxiang; An, Xiuzhi; Zhang, Meiqing; Zhang, Chunhong; Yang, Feifei; Zhi, Guang

2015-10-01

To compare three-dimensional (3D) and two-dimensional (2D) speckle tracking echocardiography (STE) techniques in the assessment of left ventricular function and myocardial infarct size (MIS). Thirty-two patients diagnosed with ST elevation myocardial infarction and 18 healthy control patients underwent 2D echocardiography, 3D echocardiography, and single photon emission computed tomography (SPECT). 3D left ventricular global area strain (GAS), 2D and 3D global longitudinal strain (GLS), global radial strain (GRS) as well as global circumferential strain (GCS) were analyzed to correlate with myocardial infarct size detected by SPECT. 2D and 3D left ventricular ejection fraction (LVEF) as well as 2D and 3D wall motion score index (WMSI) also were measured using conventional echocardiography. The 2D-GLS values were significantly higher than that of 3D-GLS, while 2D-GCS and GRS were significantly lower than 3D-GCS and GRS, respectively. However, no significant differences in LVEF and WMSI could be observed between 2D and 3D echocardiography. Myocardial strain indices, LVEF, and WMSI using 2D and 3D echocardiography also had good correlations with MIS as measured by SPECT. ROC curve analysis showed that the 3D and 2D myocardial indices, LVEF, and WMSI could distinguish between small and large MIS, while 2D-GLS had the highest AUC. The 2D and 3D myocardial strain indices correlated well with MIS by SPECT. Among them, the 2D-GLS showed the highest diagnostic value, while 3D-GRS and GCS had better diagnostic value than 2D-GRS and GCS. © 2015, Wiley Periodicals, Inc.

Lifestyle may modify the glucose-raising effect of genetic loci. A study in the Greek population.

PubMed

Marouli, E; Kanoni, S; Dimitriou, M; Kolovou, G; Deloukas, P; Dedoussis, G

2016-03-01

Lifestyle habits including dietary intake and physical activity are closely associated with multiple body processes including glucose metabolism and are known to affect human health. Recent genome-wide association studies have identified several single nucleotide polymorphisms (SNPs) associated with glucose levels. The hypothesis tested here is whether a healthy lifestyle assessed via a score is associated with glycaemic traits and whether there is an interaction between the lifestyle and known glucose-raising genetic variants in association with glycaemic traits. Participants of Greek descent from the THISEAS study were included in this analysis. We developed a glucose preventive score (GPS) including dietary and physical activity characteristics. We also modelled a weighted genetic risk score (wGRS), based on 20 known glucose-raising loci, in order to investigate the impact of lifestyle-gene interaction on glucose levels. The GPS was observed to be significantly associated with lower glucose concentrations (β ± SE: -0.083 ± 0.021 mmol/L, P = 1.6 × 10(-04)) and the wGRS, as expected, with increased glucose levels (β ± SE: 0.020 ± 0.007 mmol/L, P = 8.4 × 10(-3)). The association of the wGRS with glucose levels was attenuated after interaction with the GPS. A higher GPS indicated decreasing glucose levels in the presence of an increasing wGRS (β interaction ± SE: -0.019 ± 0.007 mmol/L, P = 0.014). Our results indicate that lower glucose levels underlie a healthier lifestyle and also support an interaction between the wGRS for known glycaemic loci and GPS associated with lower glucose levels. These scores could be useful tools for monitoring glucose metabolism. Copyright © 2016. Published by Elsevier B.V.

Global Risk Score and Clinical SYNTAX Score as Predictors of Clinical Outcomes of Patients Undergoing Unprotected Left Main Percutaneous Catheter Intervention

PubMed Central

Cuenza, Lucky; Collado, Marianne P.; Ho Khe Sui, James

2017-01-01

Background Risk stratification is an important component of left main percutaneous catheter intervention (PCI) which has emerged as a feasible alternative to cardiac surgery. We sought to compare the clinical SYNTAX score and the global risk score in predicting outcomes of patients undergoing unprotected left main PCI in our institution. Methods Clinical, angiographic and procedural characteristics of 92 patients who underwent unprotected left main PCI (mean age 62 ± 12.1 years) were analyzed. Patients were risk stratified into tertiles of high, intermediate and low risk using the global risk score (GRS) and the clinical SYNTAX score (CSS) and were prospectively followed up at 1 year for the occurrence of major adverse cardiovascular events (MACEs), defined as a composite of all cause mortality, cardiac mortality, non-fatal myocardial infarction, stroke, coronary artery bypass, and target vessel revascularization. Results There were 26 (28.2%) who experienced MACEs, of which 10 (10.8%) patients died. Multivariable hazards analysis showed that the GRS (hazard ratio (HR) = 5.5, P = 0.001) and CSS (HR = 4.3, P = 0.001) were both independent predictors of MACEs. Kaplan-Meier analysis showed higher incidence of MACEs with the intermediate and higher risk categories compared to those classified as low risk. Receiver-operator characteristic analysis showed that the GRS has better discriminatory ability than the CSS in the prediction of 1 year MACEs (0.891 vs. 0.743, P = 0.007). Conclusion The GRS and CSS are predictive of outcomes after left main PCI. The GRS appears to have superior predictive and prognostic utility compared to the CSS. This study emphasizes the importance of combining both anatomic and clinical variables for optimum prognostication and management decisions in left main PCI. PMID:29317974

Diabetes Genetic Risk Score Modifies Effect of Bisphenol A Exposure on Deterioration in Glucose Metabolism.

PubMed

Bi, Yufang; Wang, Weiqing; Xu, Min; Wang, Tiange; Lu, Jieli; Xu, Yu; Dai, Meng; Chen, Yuhong; Zhang, Di; Sun, Wanwan; Ding, Lin; Chen, Ying; Huang, Xiaolin; Lin, Lin; Qi, Lu; Lai, Shenghan; Ning, Guang

2016-01-01

Epidemiology studies showed inconsistent results regarding the relationship between bisphenol A (BPA) exposure and risk of type 2 diabetes (T2D). This study sought to prospectively investigate associations of BPA with incident T2D risk and the longitudinal changes in glycemic traits, particularly examining the interaction between gene and BPA exposure on the associations. A community-based study was conducted at baseline in 2009, including 2209 nondiabetic middle-age and elderly subjects followed for 4 y. Urinary BPA levels were measured at baseline. A genetic risk score (GRS) based on 34 T2D common variants that identified and validated in East Asians was created. Incident T2D was defined according to the 1999 World Health Organization criteria. Fasting (FPG) and 2-h post-loading plasma glucose were measured at baseline and followup. Multivariable logistic regression analysis demonstrated no significant association of risk of incident T2D with BPA while with increase in the weighted T2D-GRS (odds ratio, 1.89; 95% confidence interval, 1.31-2.72 for each 10-point increment). Similar results were found in 4-y changes of FPG and 2-h post-loading plasma glucose. The GRS modified the effect of BPA exposure on 4-y changes in FPG (P for interaction = .01). Each 1 unit of Log_BPA was associated with 0.1 mmol/L increase in FPG (P = .007) in the highest quartile of GRS; no associations were found in the lower three quartiles of GRS. The T2D genetic susceptibility significantly modulated the association of BPA exposure with longitudinal increase in FPG levels.

Polymorphisms in MIR137HG and microRNA-137-regulated genes influence gray matter structure in schizophrenia

DOE PAGES

Wright, C.; Gupta, C. N.; Chen, J.; ...

2016-02-02

Evidence suggests that microRNA-137 (miR-137) is involved in the genetic basis of schizophrenia. Risk variants within the miR-137 host gene ( MIR137HG) influence structural and functional brain-imaging measures, and miR-137 itself is predicted to regulate hundreds of genes. We evaluated the influence of a MIR137HG risk variant (rs1625579) in combination with variants in miR-137- regulated genes TCF4, PTGS2, MAPK1 and MAPK3 on gray matter concentration (GMC). These genes were selected based on our previous work assessing schizophrenia risk within possible miR-137-regulated gene sets using the same cohort of subjects. A genetic risk score (GRS) was determined based on genotypes ofmore » these four schizophrenia risk-associated genes in 221 Caucasian subjects (89 schizophrenia patients and 132 controls). The effects of the rs1625579 genotype with the GRS of miR-137-regulated genes in a three-way interaction with diagnosis on GMC patterns were assessed using a multivariate analysis. We found that schizophrenia subjects homozygous for the MIR137HG risk allele show significant decreases in occipital, parietal and temporal lobe GMC with increasing miR-137-regulated GRS, whereas those carrying the protective minor allele show significant increases in GMC with GRS. No correlations of GMC and GRS were found in control subjects. Variants within or upstream of genes regulated by miR-137 in combination with the MIR137HG risk variant may influence GMC in schizophrenia-related regions in patients. Furthermore, given that the genes evaluated here are involved in protein kinase A signaling, dysregulation of this pathway through alterations in miR-137 biogenesis may underlie the gray matter loss seen in the disease.« less

Why is the Great Red Spot Red? The Exogenic, Photolytic Origin of the UV/Blue-Absorbing Chromophores of Jupiter’s Great Red Spot as Determined by Spectral Analysis of Cassini/VIMS Observations using New Laboratory Optical Coefficients

NASA Astrophysics Data System (ADS)

Baines, Kevin H.; Carlson, Robert W.; Momary, Thomas W.

2014-11-01

For centuries, a major question for Jupiter has been: Why is the Great Red Spot red? In particular, two major theories have been proposed: (1) that the coloring is due to photolytic processes in the upper cloud layer, or (2) it is due to the upwellimg of red materials processed relatively deep within the troposphere. Utilizing indices of refraction for red choromophores generated by the photolysis of ammonia and acetylene in the laboratory, we present results of a spectral analysis of the core of Jupiter’s Great Red Spot (GRS) as observed by the visual channel of the Cassini/Visual Infrared Mapping Spectrometer (VIMS). Consistent with the physical origin of such laboratory-generated chromophores in Jupiter - i.e., by solar-driven UV photolysis within the upper levels of the GRS structure near ~ 0.3 bar - our spectral modeling yields satisfactory results for such Mie scattering chromophores only when they are confined to the upper ~ 100 mbar of the GRS. Beneath this reddish upper cloud layer, our models indicate that the remainder of the GRS cloud - assumed to extend down to at least the ammonia condensation level near 0.6 bar - must be relatively spectrally bright throughout the UV-red spectrum; that is, they must be predominantly a whitish or grey color at depth. Thus, our 0.35-1.0 micron spectral models of the GRS are inconsistent with an endogenic origin of the reddish coloring originating in the depths of Jupiter, but are consistent with a photolytic origin due to the photolysis of ammonia and acetylene in the upper troposphere.

Weighted Genetic Risk Scores and Prediction of Weight Gain in Solid Organ Transplant Populations

PubMed Central

Saigi-Morgui, Núria; Quteineh, Lina; Bochud, Pierre-Yves; Crettol, Severine; Kutalik, Zoltán; Wojtowicz, Agnieszka; Bibert, Stéphanie; Beckmann, Sonja; Mueller, Nicolas J; Binet, Isabelle; van Delden, Christian; Steiger, Jürg; Mohacsi, Paul; Stirnimann, Guido; Soccal, Paola M.; Pascual, Manuel; Eap, Chin B

2016-01-01

Background Polygenic obesity in Solid Organ Transplant (SOT) populations is considered a risk factor for the development of metabolic abnormalities and graft survival. Few studies to date have studied the genetics of weight gain in SOT recipients. We aimed to determine whether weighted genetic risk scores (w-GRS) integrating genetic polymorphisms from GWAS studies (SNP group#1 and SNP group#2) and from Candidate Gene studies (SNP group#3) influence BMI in SOT populations and if they predict ≥10% weight gain (WG) one year after transplantation. To do so, two samples (nA = 995, nB = 156) were obtained from naturalistic studies and three w-GRS were constructed and tested for association with BMI over time. Prediction of 10% WG at one year after transplantation was assessed with models containing genetic and clinical factors. Results w-GRS were associated with BMI in sample A and B combined (BMI increased by 0.14 and 0.11 units per additional risk allele in SNP group#1 and #2, respectively, p-values<0.008). w-GRS of SNP group#3 showed an effect of 0.01 kg/m2 per additional risk allele when combining sample A and B (p-value 0.04). Models with genetic factors performed better than models without in predicting 10% WG at one year after transplantation. Conclusions This is the first study in SOT evaluating extensively the association of w-GRS with BMI and the influence of clinical and genetic factors on 10% of WG one year after transplantation, showing the importance of integrating genetic factors in the final model. Genetics of obesity among SOT recipients remains an important issue and can contribute to treatment personalization and prediction of WG after transplantation. PMID:27788139

Weighted Genetic Risk Scores and Prediction of Weight Gain in Solid Organ Transplant Populations.

PubMed

Saigi-Morgui, Núria; Quteineh, Lina; Bochud, Pierre-Yves; Crettol, Severine; Kutalik, Zoltán; Wojtowicz, Agnieszka; Bibert, Stéphanie; Beckmann, Sonja; Mueller, Nicolas J; Binet, Isabelle; van Delden, Christian; Steiger, Jürg; Mohacsi, Paul; Stirnimann, Guido; Soccal, Paola M; Pascual, Manuel; Eap, Chin B

2016-01-01

Polygenic obesity in Solid Organ Transplant (SOT) populations is considered a risk factor for the development of metabolic abnormalities and graft survival. Few studies to date have studied the genetics of weight gain in SOT recipients. We aimed to determine whether weighted genetic risk scores (w-GRS) integrating genetic polymorphisms from GWAS studies (SNP group#1 and SNP group#2) and from Candidate Gene studies (SNP group#3) influence BMI in SOT populations and if they predict ≥10% weight gain (WG) one year after transplantation. To do so, two samples (nA = 995, nB = 156) were obtained from naturalistic studies and three w-GRS were constructed and tested for association with BMI over time. Prediction of 10% WG at one year after transplantation was assessed with models containing genetic and clinical factors. w-GRS were associated with BMI in sample A and B combined (BMI increased by 0.14 and 0.11 units per additional risk allele in SNP group#1 and #2, respectively, p-values<0.008). w-GRS of SNP group#3 showed an effect of 0.01 kg/m2 per additional risk allele when combining sample A and B (p-value 0.04). Models with genetic factors performed better than models without in predicting 10% WG at one year after transplantation. This is the first study in SOT evaluating extensively the association of w-GRS with BMI and the influence of clinical and genetic factors on 10% of WG one year after transplantation, showing the importance of integrating genetic factors in the final model. Genetics of obesity among SOT recipients remains an important issue and can contribute to treatment personalization and prediction of WG after transplantation.

Polymorphisms in MIR137HG and microRNA-137-regulated genes influence gray matter structure in schizophrenia

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wright, C.; Gupta, C. N.; Chen, J.

Evidence suggests that microRNA-137 (miR-137) is involved in the genetic basis of schizophrenia. Risk variants within the miR-137 host gene ( MIR137HG) influence structural and functional brain-imaging measures, and miR-137 itself is predicted to regulate hundreds of genes. We evaluated the influence of a MIR137HG risk variant (rs1625579) in combination with variants in miR-137- regulated genes TCF4, PTGS2, MAPK1 and MAPK3 on gray matter concentration (GMC). These genes were selected based on our previous work assessing schizophrenia risk within possible miR-137-regulated gene sets using the same cohort of subjects. A genetic risk score (GRS) was determined based on genotypes ofmore » these four schizophrenia risk-associated genes in 221 Caucasian subjects (89 schizophrenia patients and 132 controls). The effects of the rs1625579 genotype with the GRS of miR-137-regulated genes in a three-way interaction with diagnosis on GMC patterns were assessed using a multivariate analysis. We found that schizophrenia subjects homozygous for the MIR137HG risk allele show significant decreases in occipital, parietal and temporal lobe GMC with increasing miR-137-regulated GRS, whereas those carrying the protective minor allele show significant increases in GMC with GRS. No correlations of GMC and GRS were found in control subjects. Variants within or upstream of genes regulated by miR-137 in combination with the MIR137HG risk variant may influence GMC in schizophrenia-related regions in patients. Furthermore, given that the genes evaluated here are involved in protein kinase A signaling, dysregulation of this pathway through alterations in miR-137 biogenesis may underlie the gray matter loss seen in the disease.« less

Genetic predisposition to obesity and lifestyle factors--the combined analyses of twenty-six known BMI- and fourteen known waist:hip ratio (WHR)-associated variants in the Finnish Diabetes Prevention Study.

PubMed

Jääskeläinen, Tiina; Paananen, Jussi; Lindström, Jaana; Eriksson, Johan G; Tuomilehto, Jaakko; Uusitupa, Matti

2013-11-01

Recent genome-wide association studies have identified multiple loci associated with BMI or the waist:hip ratio (WHR). However, evidence on gene-lifestyle interactions is still scarce, and investigation of the effects of well-documented dietary and other lifestyle data is warranted to assess whether genetic risk can be modified by lifestyle. We assessed whether previously established BMI and WHR genetic variants associate with obesity and weight change in the Finnish Diabetes Prevention Study, and whether the associations are modified by dietary factors or physical activity. Individuals (n 459) completed a 3 d food record and were genotyped for twenty-six BMI- and fourteen WHR-related variants. The effects of the variants individually and in combination were investigated in relation to obesity and to 1- and 3-year weight change by calculating genetic risk scores (GRS). The GRS were separately calculated for BMI and the WHR by summing the increasing alleles weighted by their published effect sizes. At baseline, the GRS were not associated with total intakes of energy, macronutrients or fibre. The mean 1- and 3-year weight changes were not affected by the BMI or WHR GRS. During the 3-year follow-up, a trend for higher BMI by the GRS was detected especially in those who reported a diet low in fibre (P for interaction=0·065). Based on the present findings, it appears unlikely that obesity-predisposing variants substantially modify the effect of lifestyle modification on the success of weight reduction in the long term. In addition, these findings suggest that the association between the BMI-related genetic variants and obesity could be modulated by the diet.

Association between Vitamin D Genetic Risk Score and Cancer Risk in a Large Cohort of U.S. Women

PubMed Central

Chandler, Paulette D.; Tobias, Deirdre K.; Wang, Lu; Smith-Warner, Stephanie A.; Chasman, Daniel I.; Rose, Lynda; Giovannucci, Edward L.; Buring, Julie E.; Ridker, Paul M.; Cook, Nancy R.; Manson, JoAnn E.; Sesso, Howard D.

2018-01-01

Some observational studies suggest an inverse association between circulating 25-hydroxyvitamin D (25OHD) and cancer incidence and mortality. We conducted a Mendelian randomization analysis of the relationship between a vitamin D genetic risk score (GRS, range 0–10), comprised of five single nucleotide polymorphisms (SNPs) of vitamin D status in the DHCR7, CYP2R1 and GC genes and cancer risk among women. Analysis was performed in the Women’s Genome Health Study (WGHS), including 23,294 women of European ancestry who were cancer-free at baseline and followed for 20 years for incident cancer. In a subgroup of 1782 WGHS participants with 25OHD measures at baseline, the GRS was associated with circulating 25OHD mean (SD) = 67.8 (26.1) nmol/L, 56.9 (18.7) nmol/L in the lowest versus 73.2 (27.9) nmol/L in the highest quintile of the GRS (p trend < 0.0001 across quintiles). However, in age-adjusted Cox proportional hazards models, higher GRS (reflecting higher 25OHD levels) was not associated (cases; Hazard Ratio (HR) (95% Confidence Interval (CI)), p-value) with incident total cancer: (n = 3985; 1.01 (1.00–1.03), p = 0.17), breast (n = 1560; 1.02 (0.99–1.05), p = 0.21), colorectal (n = 329; 1.06 (1.00–1.13), p = 0.07), lung (n = 330; 1.00 (0.94–1.06), p = 0.89) or total cancer death (n = 770; 1.00 (0.96–1.04), p = 0.90). Results were similar in fully-adjusted models. A GRS for higher circulating 25OHD was not associated with cancer incidence or mortality. PMID:29315215

Position and morphology of the compact non-thermal radio source at the Galactic Center

NASA Technical Reports Server (NTRS)

Marcaide, J. M.; Alberdi, A.; Bartel, N.; Clark, T. A.; Corey, B. E.; Elosegui, P.; Gorenstein, M. V.; Guirado, J. C.; Kardashev, N.; Popov, M.

1992-01-01

We have determined with VLBI the position of the compact nonthermal radio source at the Galactic Center, commonly referred to as SgrA*, in the J2000.0 reference frame of extragalactic radio sources. We have also determined the size of SgrA* at 1.3, 3.6, and 13 cm wavelengths and found that the apparent size of the source increases proportionally to the observing wavelength squared, as expected from source size broadening by interstellar scattering and as reported previously by other authors. We have also established an upper limit of about 8 mJy at 3.6 cm wavelength for any ultracompact component. The actual size of the source is less than 15 AU. Fourier analysis of our very sensitive 3.6 cm observations of this source shows no significant variations of correlated flux density on time scales from 12 to 700 s.

The Galactic Magnetic Field as Viewed from the VLA

NASA Astrophysics Data System (ADS)

van Eck, Cameron; Brown, Jo-Anne

2009-05-01

Interstellar magnetic fields play critical roles in many astrophysical processes. Yet despite their importance, our knowledge about magnetic fields in our Galaxy remains limited. For the field within the Milky Way much of what we do know comes from radio astronomy, through observations of polarization and Faraday rotation measures (RMs) of extragalactic sources and pulsars. A high angular density of RM measurements in several critical areas of the Galaxy is needed to clarify the Galactic magnetic field structure. Understanding the overall structure of the magnetic field will subsequently help us determine the origin and evolution of the field. In an effort to determine the overall structure of the field, Sun et al. (2008) produced 3 models of the Galactic magnetic field based on RM measurements available at the time. These models made distinct predictions for RMs in a region of the inner Galaxy at low Galactic latitude. Using observations made with the Very Large Array (VLA), we have determined RMs for sources in this critical region. In this talk we will present the results of our study and show how the RMs strongly support the ASS+RING model.

An infrared sky model based on the IRAS point source data

NASA Technical Reports Server (NTRS)

Cohen, Martin; Walker, Russell; Wainscoat, Richard; Volk, Kevin; Walker, Helen; Schwartz, Deborah

1990-01-01

A detailed model for the infrared point source sky is presented that comprises geometrically and physically realistic representations of the galactic disk, bulge, spheroid, spiral arms, molecular ring, and absolute magnitudes. The model was guided by a parallel Monte Carlo simulation of the Galaxy. The content of the galactic source table constitutes an excellent match to the 12 micrometer luminosity function in the simulation, as well as the luminosity functions at V and K. Models are given for predicting the density of asteroids to be observed, and the diffuse background radiance of the Zodiacal cloud. The model can be used to predict the character of the point source sky expected for observations from future infrared space experiments.

Reconciling different observations of the CO2 ice mass loading of the Martian north polar cap

USGS Publications Warehouse

Haberle, R.M.; Mattingly, B.; Titus, T.N.

2004-01-01

The GRS measurements of the peak mass loading of the north polar CO2 ice cap on Mars are about 60% lower than those calculated from MGS TES radiation data and those inferred from the MOLA cap thicknesses. However, the GRS data provide the most accurate measurement of the mass loading. We show that the TES and MOLA data can be reconciled with the GRS data if (1) subsurface heat conduction and atmospheric heat transport are included in the TES mass budget calculations, and (2) the density of the polar deposits is ???600 kg m-3. The latter is much less than that expected for slab ice (???1600 kg m-3) and suggests that processes unique to the north polar region are responsible for the low cap density. Copyright 2004 by the American Geophysical Union.

Galileo's First Images of Jupiter and the Galilean Satellites

PubMed

Belton, M J S; Head, J W; Ingersoll, A P; Greeley, R; McEwen, A S; Klaasen, K P; Senske, D; Pappalardo, R; Collins, G; Vasavada, A R; Sullivan, R; Simonelli, D; Geissler, P; Carr, M H; Davies, M E; Veverka, J; Gierasch, P J; Banfield, D; Bell, M; Chapman, C R; Anger, C; Greenberg, R; Neukum, G; Pilcher, C B; Beebe, R F; Burns, J A; Fanale, F; Ip, W; Johnson, T V; Morrison, D; Moore, J; Orton, G S; Thomas, P; West, R A

1996-10-18

The first images of Jupiter, Io, Europa, and Ganymede from the Galileo spacecraft reveal new information about Jupiter's Great Red Spot (GRS) and the surfaces of the Galilean satellites. Features similar to clusters of thunderstorms were found in the GRS. Nearby wave structures suggest that the GRS may be a shallow atmospheric feature. Changes in surface color and plume distribution indicate differences in resurfacing processes near hot spots on Io. Patchy emissions were seen while Io was in eclipse by Jupiter. The outer margins of prominent linear markings (triple bands) on Europa are diffuse, suggesting that material has been vented from fractures. Numerous small circular craters indicate localized areas of relatively old surface. Pervasive brittle deformation of an ice layer appears to have formed grooves on Ganymede. Dark terrain unexpectedly shows distinctive albedo variations to the limit of resolution.

Galileo's first images of Jupiter and the Galilean satellites

USGS Publications Warehouse

Belton, M.J.S.; Head, J. W.; Ingersoll, A.P.; Greeley, R.; McEwen, A.S.; Klaasen, K.P.; Senske, D.; Pappalardo, R.; Collins, G.; Vasavada, A.R.; Sullivan, R.; Simonelli, D.; Geissler, P.; Carr, M.H.; Davies, M.E.; Veverka, J.; Gierasch, P.J.; Banfield, D.; Bell, M.; Chapman, C.R.; Anger, C.; Greenberg, R.; Neukum, G.; Pilcher, C.B.; Beebe, R.F.; Burns, J.A.; Fanale, F.; Ip, W.; Johnson, T.V.; Morrison, D.; Moore, J.; Orton, G.S.; Thomas, P.; West, R.A.

1996-01-01

The first images of Jupiter, Io, Europa, and Ganymede from the Galileo spacecraft reveal new information about Jupiter's Great Red Spot (GRS) and the surfaces of the Galilean satellites. Features similar to clusters of thunderstorms were found in the GRS. Nearby wave structures suggest that the GRS may be a shallow atmospheric feature. Changes in surface color and plume distribution indicate differences in resurfacing processes near hot spots on lo. Patchy emissions were seen while Io was in eclipse by Jupiter. The outer margins of prominent linear markings (triple bands) on Europa are diffuse, suggesting that material has been vented from fractures. Numerous small circular craters indicate localized areas of relatively old surface. Pervasive brittle deformation of an ice layer appears to have formed grooves on Ganymede. Dark terrain unexpectedly shows distinctive albedo variations to the limit of resolution.

The Chandra Source Catalog: Source Variability

NASA Astrophysics Data System (ADS)

Nowak, Michael; Rots, A. H.; McCollough, M. L.; Primini, F. A.; Glotfelty, K. J.; Bonaventura, N. R.; Chen, J. C.; Davis, J. E.; Doe, S. M.; Evans, J. D.; Fabbiano, G.; Galle, E.; Gibbs, D. G.; Grier, J. D.; Hain, R.; Hall, D. M.; Harbo, P. N.; He, X.; Houck, J. C.; Karovska, M.; Lauer, J.; McDowell, J. C.; Miller, J. B.; Mitschang, A. W.; Morgan, D. L.; Nichols, J. S.; Plummer, D. A.; Refsdal, B. L.; Siemiginowska, A. L.; Sundheim, B. A.; Tibbetts, M. S.; Van Stone, D. W.; Winkelman, S. L.; Zografou, P.

2009-01-01

The Chandra Source Catalog (CSC) contains fields of view that have been studied with individual, uninterrupted observations that span integration times ranging from 1 ksec to 160 ksec, and a large number of which have received (multiple) repeat observations days to years later. The CSC thus offers an unprecedented look at the variability of the X-ray sky over a broad range of time scales, and across a wide diversity of variable X-ray sources: stars in the local galactic neighborhood, galactic and extragalactic X-ray binaries, Active Galactic Nuclei, etc. Here we describe the methods used to identify and quantify source variability within a single observation, and the methods used to assess the variability of a source when detected in multiple, individual observations. Three tests are used to detect source variability within a single observation: the Kolmogorov-Smirnov test and its variant, the Kuiper test, and a Bayesian approach originally suggested by Gregory and Loredo. The latter test not only provides an indicator of variability, but is also used to create a best estimate of the variable lightcurve shape. We assess the performance of these tests via simulation of statistically stationary, variable processes with arbitrary input power spectral densities (here we concentrate on results of red noise simulations) at variety of mean count rates and fractional root mean square variabilities relevant to CSC sources. We also assess the false positive rate via simulations of constant sources whose sole source of fluctuation is Poisson noise. We compare these simulations to a preliminary assessment of the variability found in real CSC sources, and estimate the variability sensitivities of the CSC.

The Chandra Source Catalog: Source Variability

NASA Astrophysics Data System (ADS)

Nowak, Michael; Rots, A. H.; McCollough, M. L.; Primini, F. A.; Glotfelty, K. J.; Bonaventura, N. R.; Chen, J. C.; Davis, J. E.; Doe, S. M.; Evans, J. D.; Evans, I.; Fabbiano, G.; Galle, E. C.; Gibbs, D. G., II; Grier, J. D.; Hain, R.; Hall, D. M.; Harbo, P. N.; He, X.; Houck, J. C.; Karovska, M.; Lauer, J.; McDowell, J. C.; Miller, J. B.; Mitschang, A. W.; Morgan, D. L.; Nichols, J. S.; Plummer, D. A.; Refsdal, B. L.; Siemiginowska, A. L.; Sundheim, B. A.; Tibbetts, M. S.; van Stone, D. W.; Winkelman, S. L.; Zografou, P.

2009-09-01

The Chandra Source Catalog (CSC) contains fields of view that have been studied with individual, uninterrupted observations that span integration times ranging from 1 ksec to 160 ksec, and a large number of which have received (multiple) repeat observations days to years later. The CSC thus offers an unprecedented look at the variability of the X-ray sky over a broad range of time scales, and across a wide diversity of variable X-ray sources: stars in the local galactic neighborhood, galactic and extragalactic X-ray binaries, Active Galactic Nuclei, etc. Here we describe the methods used to identify and quantify source variability within a single observation, and the methods used to assess the variability of a source when detected in multiple, individual observations. Three tests are used to detect source variability within a single observation: the Kolmogorov-Smirnov test and its variant, the Kuiper test, and a Bayesian approach originally suggested by Gregory and Loredo. The latter test not only provides an indicator of variability, but is also used to create a best estimate of the variable lightcurve shape. We assess the performance of these tests via simulation of statistically stationary, variable processes with arbitrary input power spectral densities (here we concentrate on results of red noise simulations) at variety of mean count rates and fractional root mean square variabilities relevant to CSC sources. We also assess the false positive rate via simulations of constant sources whose sole source of fluctuation is Poisson noise. We compare these simulations to an assessment of the variability found in real CSC sources, and estimate the variability sensitivities of the CSC.

Hi-GAL, the Herschel infrared Galactic Plane Survey: photometric maps and compact source catalogues. First data release for the inner Milky Way: +68° ≥ l ≥ -70°

NASA Astrophysics Data System (ADS)

Molinari, S.; Schisano, E.; Elia, D.; Pestalozzi, M.; Traficante, A.; Pezzuto, S.; Swinyard, B. M.; Noriega-Crespo, A.; Bally, J.; Moore, T. J. T.; Plume, R.; Zavagno, A.; di Giorgio, A. M.; Liu, S. J.; Pilbratt, G. L.; Mottram, J. C.; Russeil, D.; Piazzo, L.; Veneziani, M.; Benedettini, M.; Calzoletti, L.; Faustini, F.; Natoli, P.; Piacentini, F.; Merello, M.; Palmese, A.; Del Grande, R.; Polychroni, D.; Rygl, K. L. J.; Polenta, G.; Barlow, M. J.; Bernard, J.-P.; Martin, P. G.; Testi, L.; Ali, B.; André, P.; Beltrán, M. T.; Billot, N.; Carey, S.; Cesaroni, R.; Compiègne, M.; Eden, D.; Fukui, Y.; Garcia-Lario, P.; Hoare, M. G.; Huang, M.; Joncas, G.; Lim, T. L.; Lord, S. D.; Martinavarro-Armengol, S.; Motte, F.; Paladini, R.; Paradis, D.; Peretto, N.; Robitaille, T.; Schilke, P.; Schneider, N.; Schulz, B.; Sibthorpe, B.; Strafella, F.; Thompson, M. A.; Umana, G.; Ward-Thompson, D.; Wyrowski, F.

2016-07-01

Aims: We present the first public release of high-quality data products (DR1) from Hi-GAL, the Herschel infrared Galactic Plane Survey. Hi-GAL is the keystone of a suite of continuum Galactic plane surveys from the near-IR to the radio and covers five wavebands at 70, 160, 250, 350 and 500 μm, encompassing the peak of the spectral energy distribution of cold dust for 8 ≲ T ≲ 50 K. This first Hi-GAL data release covers the inner Milky Way in the longitude range 68° ≳ ℓ ≳ -70° in a | b | ≤ 1° latitude strip. Methods: Photometric maps have been produced with the ROMAGAL pipeline, which optimally capitalizes on the excellent sensitivity and stability of the bolometer arrays of the Herschel PACS and SPIRE photometric cameras. It delivers images of exquisite quality and dynamical range, absolutely calibrated with Planck and IRAS, and recovers extended emission at all wavelengths and all spatial scales, from the point-spread function to the size of an entire 2°× 2° "tile" that is the unit observing block of the survey. The compact source catalogues were generated with the CuTEx algorithm, which was specifically developed to optimise source detection and extraction in the extreme conditions of intense and spatially varying background that are found in the Galactic plane in the thermal infrared. Results: Hi-GAL DR1 images are cirrus noise limited and reach the 1σ-rms predicted by the Herschel Time Estimators for parallel-mode observations at 60'' s-1 scanning speed in relatively low cirrus emission regions. Hi-GAL DR1 images will be accessible through a dedicated web-based image cutout service. The DR1 Compact Source Catalogues are delivered as single-band photometric lists containing, in addition to source position, peak, and integrated flux and source sizes, a variety of parameters useful to assess the quality and reliability of the extracted sources. Caveats and hints to help in this assessment are provided. Flux completeness limits in all bands are determined from extensive synthetic source experiments and greatly depend on the specific line of sight along the Galactic plane because the background strongly varies as a function of Galactic longitude. Hi-GAL DR1 catalogues contain 123210, 308509, 280685, 160972, and 85460 compact sources in the five bands. Herschel is an ESA space observatory with science instruments provided by European-led Principal Investigator consortia and with important participation from NASA.The images and the catalogues are only available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (http://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/591/A149

Deciphering the Dipole Anisotropy of Galactic Cosmic Rays.

PubMed

Ahlers, Markus

2016-10-07

Recent measurements of the dipole anisotropy in the arrival directions of Galactic cosmic rays (CRs) indicate a strong energy dependence of the dipole amplitude and phase in the TeV-PeV range. We argue here that these observations can be well understood within standard diffusion theory as a combined effect of (i) one or more local sources at Galactic longitude 120°≲l≲300° dominating the CR gradient below 0.1-0.3 PeV, (ii) the presence of a strong ordered magnetic field in our local environment, (iii) the relative motion of the solar system, and (iv) the limited reconstruction capabilities of ground-based observatories. We show that an excellent candidate of the local CR source responsible for the dipole anisotropy at 1-100 TeV is the Vela supernova remnant.

GRIS observations of Al-26 gamma-ray line emission from two points in the Galactic plane

NASA Technical Reports Server (NTRS)

Teegarden, B. J.; Barthelmy, S. D.; Gehrels, N.; Tueller, J.; Leventhal, M.

1991-01-01

Both of the Gamma-Ray Imaging Spectrometer (GRIS) experiment's two observations of the Galactic center region, at l = zero and 335 deg respectively, detected Al-26 gamma-ray line emission. While these observations are consistent with the assumed high-energy gamma-ray distribution, they are consistent with other distributions as well. The data suggest that the Al-26 emission is distributed over Galactic longitude rather than being confined to a point source. The GRIS data also indicate that the 1809 keV line is broadened.

Gamma-ray spectroscopy: The diffuse galactic glow

NASA Technical Reports Server (NTRS)

Hartmann, Dieter H.

1991-01-01

The goal of this project is the development of a numerical code that provides statistical models of the sky distribution of gamma-ray lines due to the production of radioactive isotopes by ongoing Galactic nucleosynthesis. We are particularly interested in quasi-steady emission from novae, supernovae, and stellar winds, but continuum radiation and transient sources must also be considered. We have made significant progress during the first half period of this project and expect the timely completion of a code that can be applied to Oriented Scintillation Spectrometer Experiment (OSSE) Galactic plane survey data.

Demographics and Case Studies of Galactic Outflows in the Local Universe

NASA Astrophysics Data System (ADS)

Rupke, David

2017-07-01

Galactic outflows driven by both star formation and active black holes are an important driver of galaxy evolution. The local universe is a sensitive laboratory for understanding the scaling relations that characterize these winds and the physics that govern them. I will review what we know from statistical studies about the prevalance and properties of nearby galactic winds and how these properties depend on those of the host galaxy or power source. I will also highlight detailed case studies of key objects that illustrate the multiphase structure of these winds.

The Profile of the Galactic Halo from Pan-STARRS1 3π RR Lyrae

NASA Astrophysics Data System (ADS)

Hernitschek, Nina; Cohen, Judith G.; Rix, Hans-Walter; Sesar, Branimir; Martin, Nicolas F.; Magnier, Eugene; Wainscoat, Richard; Kaiser, Nick; Tonry, John L.; Kudritzki, Rolf-Peter; Hodapp, Klaus; Chambers, Ken; Flewelling, Heather; Burgett, William

2018-05-01

We characterize the spatial density of the Pan-STARRS1 (PS1) sample of Rrab stars to study the properties of the old Galactic stellar halo. This sample, containing 44,403 sources, spans galactocentric radii of 0.55 kpc ≤ R gc ≤ 141 kpc with a distance precision of 3% and thus is able to trace the halo out to larger distances than most previous studies. After excising stars that are attributed to dense regions such as stellar streams, the Galactic disk and bulge, and halo globular clusters, the sample contains ∼11,000 sources within 20 kpc ≤ R gc ≤ 131 kpc. We then apply forward modeling using Galactic halo profile models with a sample selection function. Specifically, we use ellipsoidal stellar density models ρ(l, b, R gc) with a constant and a radius-dependent halo flattening q(R gc). Assuming constant flattening q, the distribution of the sources is reasonably well fit by a single power law with n={4.40}-0.04+0.05 and q={0.918}-0.014+0.016 and comparably well fit by an Einasto profile with n={9.53}-0.28+0.27, an effective radius r eff = 1.07 ± 0.10 kpc, and a halo flattening of q = 0.923 ± 0.007. If we allow for a radius-dependent flattening q(R gc), we find evidence for a distinct flattening of q ∼ 0.8 of the inner halo at ∼25 kpc. Additionally, we find that the south Galactic hemisphere is more flattened than the north Galactic hemisphere. The results of our work are largely consistent with many earlier results (e.g., Watkins et al.; Iorio et al.). We find that the stellar halo, as traced in RR Lyrae stars, exhibits a substantial number of further significant over- and underdensities, even after masking all known overdensities.

A comparison of Google Glass and traditional video vantage points for bedside procedural skill assessment.

PubMed

Evans, Heather L; O'Shea, Dylan J; Morris, Amy E; Keys, Kari A; Wright, Andrew S; Schaad, Douglas C; Ilgen, Jonathan S

2016-02-01

This pilot study assessed the feasibility of using first person (1P) video recording with Google Glass (GG) to assess procedural skills, as compared with traditional third person (3P) video. We hypothesized that raters reviewing 1P videos would visualize more procedural steps with greater inter-rater reliability than 3P rating vantages. Seven subjects performed simulated internal jugular catheter insertions. Procedures were recorded by both Google Glass and an observer's head-mounted camera. Videos were assessed by 3 expert raters using a task-specific checklist (CL) and both an additive- and summative-global rating scale (GRS). Mean scores were compared by t-tests. Inter-rater reliabilities were calculated using intraclass correlation coefficients. The 1P vantage was associated with a significantly higher mean CL score than the 3P vantage (7.9 vs 6.9, P = .02). Mean GRS scores were not significantly different. Mean inter-rater reliabilities for the CL, additive-GRS, and summative-GRS were similar between vantages. 1P vantage recordings may improve visualization of tasks for behaviorally anchored instruments (eg, CLs), whereas maintaining similar global ratings and inter-rater reliability when compared with conventional 3P vantage recordings. Copyright © 2016 Elsevier Inc. All rights reserved.

Mapping Potassium

NASA Image and Video Library

2015-04-16

During the first year of NASA MESSENGER orbital mission, the spacecraft GRS instrument measured the elemental composition of Mercury surface materials. mong the most important discoveries from the GRS was the observation of higher abundances of the moderately volatile elements potassium, sodium, and chlorine than expected from previous scientific models and theories. Particularly high concentrations of these elements were observed at high northern latitudes, as illustrated in this potassium abundance map, which provides a view of the surface centered at 60° N latitude and 120° E longitude. This map was the first elemental map ever made of Mercury's surface and is to-date the only map to report absolute elemental concentrations, in comparison to element ratios. Prior to MESSENGER's arrival at Mercury, scientists expected that the planet would be depleted in moderately volatile elements, as is the case for our Moon. The unexpectedly high abundances observed with the GRS have forced a reevaluation of our understanding of the formation and evolution of Mercury. In addition, the K map provided the first evidence for distinct geochemical terranes on Mercury, as the high-potassium region was later found to also be distinct in its low Mg/Si, Ca/Si, S/Si, and high Na/Si and Cl/Si abundances. Instrument: Gamma-Ray Spectrometer (GRS) http://photojournal.jpl.nasa.gov/catalog/PIA19414

Changing values of farm animal genomic resources. from historical breeds to the Nagoya Protocol.

PubMed

Tamminen, Sakari

2015-01-01

The paper reviews the history of Animal genetic resources (AnGRs) and claims that over the course of history they have been conceptually transformed from economic, ecologic and scientific life forms into political objects, reflecting in the way in which any valuation of AnGRs is today inherently imbued with national politics and its values enacted by legally binding global conventions. Historically, the first calls to conservation were based on the economic, ecological and scientific values of the AnGR. While the historical arguments are valid and still commonly proposed values for conservation, the AnGR have become highly politicized since the adoption of the Convention of Biological Diversity (CBD), the subsequent Interlaken Declaration, the Global Plan for Action (GPA) and the Nagoya Protocol. The scientific and political definitions of the AnGRs were creatively reshuffled within these documents and the key criteria by which they are now identified and valued today were essentially redefined. The criteria of "in situ condition" has become the necessary starting point for all valuation efforts of AnGRs, effectively transforming their previous nature as natural property and global genetic commons into objects of national concern pertaining to territorially discrete national genetic landscapes, regulated by the sovereign powers of the parties to the global conventions.

Exploring the nature of the unidentified very-high-energy gamma-ray source HESS J1507-622

NASA Astrophysics Data System (ADS)

Domainko, W.; Ohm, S.

2012-09-01

Context. Several extended sources of very-high-energy (VHE; E > 100 GeV) gamma rays have been found that lack counterparts belonging to an established class of VHE gamma-ray emitters. Aims: The nature of the first unidentified VHE gamma-ray source with significant angular offset from the Galactic plane of 3.5°, HESS J1507-622, is explored. Methods.Fermi-LAT data in the high-energy (HE, 100 MeV < E < 100 GeV) gamma-ray range collected over 34 month are used to describe the spectral energy distribution (SED) of the source. Additionally, implications of the off-plane location of the source for a leptonic and hadronic gamma-ray emission model are investigated. Results: HESS J1507-622 is detected in the Fermi energy range and its spectrum is best described by a power law in energy with Γ = 1.7 ± 0.1stat ± 0.2sys and integral flux between (0.3-300) GeV of F = (2.0 ± 0.5stat ± 1.0sys) × 10-9 cm-2 s-1. The SED constructed from the Fermi and H.E.S.S. data for this source does not support a smooth power-law continuation from the VHE to the HE gamma-ray range. With the available data it is not possible to discriminate between a hadronic and a leptonic scenario for HESS J1507-622. The location and compactness of the source indicate a considerable physical offset from the Galactic plane for this object. In case of a multiple-kpc distance, this challenges a pulsar wind nebula (PWN) origin for HESS J1507-622 since the time of travel for a pulsar born in the Galactic disk to reach such a location would exceed the inverse Compton (IC) cooling time of electrons that are energetic enough to produce VHE gamma-rays. However, an origin of this gamma-ray source connected to a pulsar that was born off the Galactic plane in the explosion of a hypervelocity star cannot be excluded. Conclusions: The nature of HESS J1507-622 is still unknown to date, and a PWN scenario cannot be ruled out in general. On the contrary HESS J1507-622 could be the first discovered representative of a population of spatially extended VHE gamma-ray emitters with HE gamma-ray counterpart that are located at considerable offsets from the Galactic plane. Future surveys in the VHE gamma-ray range are necessary to probe the presence or absence of such a source population.

Sky distribution of artificial sources in the galactic belt of advanced cosmic life.

PubMed

Heidmann, J

1994-12-01

In line with the concept of the galactic belt of advanced life, we evaluate the sky distribution of detectable artificial sources, using a simple astrophysical model. The best region to search is the median band of the Milky Way in the Vulpecula-Cygnus region, together with a narrower one in Carina. Although this work was done in view of a proposal to send a SETI probe at a gravitational focus of the Sun, we recommend these sky regions particularly for the searches of the sky survey type.

Discovery of localized TeV gamma-ray sources and diffuse TeV gamma-ray emission from the galactic plane with Milagro using a new background rejection technique

NASA Astrophysics Data System (ADS)

Abdo, Aws Ahmad

2007-08-01

Very high energy gamma-rays can be used to probe some of the most powerful astrophysical objects in the universe, such as active galactic nuclei, supernova remnants and pulsar-powered nebulae. The diffuse gamma radiation arising from the interaction of cosmic-ray particles with matter and radiation in the Galaxy is one of the few probes available to study the origin of cosmic- rays. Milagro is a water Cherenkov detector that continuously views the entire overhead sky. The large field-of-view combined with the long observation time makes Milagro the most sensitive instrument available for the study of large, low surface brightness sources such as the diffuse gamma radiation arising from interactions of cosmic radiation with interstellar matter. In this thesis I present a new background rejection technique for the Milagro detector through the development of a new gamma hadron separation variable. The Abdo variable, A 4 , coupled with the weighting analysis technique significantly improves the sensitivity of the Milagro detector. This new analysis technique resulted in the first discoveries in Milagro. Four localized sources of TeV gamma-ray emission have been discovered, three of which are in the Cygnus region of the Galaxy and one closer to the Galactic center. In addition to these localized sources, a diffuse emission of TeV gamma-rays has been discovered from the Cygnus region of the Galaxy as well. However, the TeV gamma-ray flux as measured at ~12 TeV from the Cygnus region exceeds that predicted from a conventional model of cosmic-ray production and propagation. This observation indicates the existence of either hard-spectrum cosmic-ray sources and/or other sources of TeV gamma rays in the region. Other TeV gamma-ray source candidates with post-trial statistical significances of > 4s have also been observed in the Galactic plane.

Galactic Sources Detected in the NuSTAR Serendipitous Survey

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tomsick, John A.; Clavel, Maïca; Chiu, Jeng-Lun

The Nuclear Spectroscopic Telescope Array (NuSTAR) provides an improvement in sensitivity at energies above 10 keV by two orders of magnitude over non-focusing satellites, making it possible to probe deeper into the Galaxy and universe. Lansbury and collaborators recently completed a catalog of 497 sources serendipitously detected in the 3–24 keV band using 13 deg{sup 2} of NuSTAR coverage. Here, we report on an optical and X-ray study of 16 Galactic sources in the catalog. We identify 8 of them as stars (but some or all could have binary companions), and use information from Gaia to report distances and X-ray luminositiesmore » for 3 of them. There are 4 CVs or CV candidates, and we argue that NuSTAR J233426–2343.9 is a relatively strong CV candidate based partly on an X-ray spectrum from XMM-Newton . NuSTAR J092418–3142.2, which is the brightest serendipitous source in the Lansbury catalog, and NuSTAR J073959–3147.8 are low-mass X-ray binary candidates, but it is also possible that these 2 sources are CVs. One of the sources is a known high-mass X-ray binary (HMXB), and NuSTAR J105008–5958.8 is a new HMXB candidate that has strong Balmer emission lines in its optical spectrum and a hard X-ray spectrum. We discuss the implications of finding these HMXBs for the surface density (log N –log S ) and luminosity function of Galactic HMXBs. We conclude that with the large fraction of unclassified sources in the Galactic plane detected by NuSTAR in the 8–24 keV band, there could be a significant population of low-luminosity HMXBs.« less

Determining the nature of faint X-ray sources from the ASCA Galactic center survey

NASA Astrophysics Data System (ADS)

Lutovinov, A. A.; Revnivtsev, M. G.; Karasev, D. I.; Shimansky, V. V.; Burenin, R. A.; Bikmaev, I. F.; Vorob'ev, V. S.; Tsygankov, S. S.; Pavlinsky, M. N.

2015-05-01

We present the results of the the identification of six objects from the ASCA Galactic center and Galactic plane surveys: AX J173548-3207, AX J173628-3141, AX J1739.5-2910, AX J1740.4-2856, AX J1740.5-2937, and AX J1743.9-2846. Chandra, XMM-Newton, and XRT/Swift X-ray data have been used to improve the positions of the optical counterparts to these sources. Thereafter, we have carried out a series of spectroscopic observations of the established optical counterparts at the RTT-150 telescope. Analysis of X-ray and optical spectra as well as photometric measurements in a wide wavelength range based on optical and infrared catalogs has allowed the nature of the program sources to be determined. Two X-ray objects have been detected in the error circle of AX J173628-3141: one is a coronally active G star and the other may be a symbiotic star, a red giant with an accreting white dwarf. Three sources (AX J1739.5-2910, AX J1740.5-2937, AX J1743.9-2846) have turned out to be active G-K stars, presumably RS CVn objects, one (AX J1740.4-2856) is an M dwarf, and another one (AX J173548-3207) most likely a low-mass X-ray binary in its low state. The distances and corresponding luminosities of the sources in the soft X-ray band (0.5-10 keV) have been estimated; analysis of deep INTEGRAL Galactic center observations has not revealed a statistically significant flux at energies >20 keV from any of them.

SEARCH FOR SOURCES OF HIGH-ENERGY NEUTRONS WITH FOUR YEARS OF DATA FROM THE ICETOP DETECTOR

DOE Office of Scientific and Technical Information (OSTI.GOV)

Aartsen, M. G.; Abraham, K.; Ackermann, M.

IceTop is an air-shower array located on the Antarctic ice sheet at the geographic South Pole. IceTop can detect an astrophysical flux of neutrons from Galactic sources as an excess of cosmic-ray air showers arriving from the source direction. Neutrons are undeflected by the Galactic magnetic field and can typically travel 10 ( E /PeV) pc before decay. Two searches are performed using 4 yr of the IceTop data set to look for a statistically significant excess of events with energies above 10 PeV (10{sup 16} eV) arriving within a small solid angle. The all-sky search method covers from −90°more » to approximately −50° in declination. No significant excess is found. A targeted search is also performed, looking for significant correlation with candidate sources in different target sets. This search uses a higher-energy cut (100 PeV) since most target objects lie beyond 1 kpc. The target sets include pulsars with confirmed TeV energy photon fluxes and high-mass X-ray binaries. No significant correlation is found for any target set. Flux upper limits are determined for both searches, which can constrain Galactic neutron sources and production scenarios.« less

Observations of low luminosity X-ray sources in Vela-Puppis

NASA Technical Reports Server (NTRS)

Pravdo, S. H.; Becker, R. H.; Boldt, E. A.; Holt, S. S.; Erlemitsos, P. J.; Swank, J. H.

1978-01-01

Results of a study of the X-ray emission from a small portion of the galactic plane near galactic longitude 260 deg are presented. This region contains at least six low luminosity X-ray sources within approximately 10 deg. of PSRO833-45, which is near the center of the Gum Nebula. The X-ray source associated with the Vela pulsar, 4U0833-45, is observed at twice its 4U catalogue intensity. The lack of X-ray pulsations at the pulsar period, the non thermal power law spectrum, and models of the X-ray come from an extended source approximately 1 deg in radius. The observation of a high temperature spectrum in a field of view containing only Puppis A among known sources has led to the discovery of a new OSO-8 source, OSO752-39. Other spectra from this region are discussed.

Near Real-Time Imaging of the Galactic Plane with BATSE

NASA Technical Reports Server (NTRS)

Harmon, B. A.; Zhang, S. N.; Robinson, C. R.; Paciesas, W. S.; Barret, D.; Grindlay, J.; Bloser, P.; Monnelly, C.

1997-01-01

The discovery of new transient or persistent sources in the hard X-ray regime with the BATSE Earth occultation Technique has been limited previously to bright sources of about 200 mCrab or more. While monitoring known source locations is not a problem to a daily limiting sensitivity of about 75 mCrab, the lack of a reliable background model forces us to use more intensive computer techniques to find weak, previously unknown emission from hard X-ray/gamma sources. The combination of Radon transform imaging of the galactic plane in 10 by 10 degree fields and the Harvard/CFA-developed Image Search (CBIS) allows us to straightforwardly search the sky for candidate sources in a +/- 20 degree latitude band along the plane. This procedure has been operating routinely on a weekly basis since spring 1997. We briefly describe the procedure, then concentrate on the performance aspects of the technique and candidate source results from the search.

Sco X-1 - A galactic radio source with an extragalactic radio morphology

NASA Technical Reports Server (NTRS)

Geldzahler, B. J.; Corey, B. E.; Fomalont, E. B.; Hilldrup, K.

1981-01-01

VLA observations of radio emissions at 1465 and 4885 MHz, of Sco X-1 confirm the existence of a colinear triple structure. Evidence that the three components of Sco X-1 are physically associated is presented, including the morphology, spectrum, variability, volume emissivity and magnetic field strength. The possibility of a physical phenomenon occurring in Sco X-1 similar to that occurring in extragalactic radio sources is discussed, and two galactic sources are found having extended emission similar to that in extragalactic objects. The extended structure of Sco X-1 is also observed to be similar to that of the hot spots in luminous extragalactic sources, and a radio source 20 arcmin from Sco X-1 is found to lie nearly along the radio axis formed by the components of Sco X-1.

X-ray and gamma-ray emission of Sagittarius A* as a wind-accreting black hole

NASA Technical Reports Server (NTRS)

Mastichiadis, A.; Ozernoy, L. M.

1994-01-01

If, as many believe, Sgr A* is a massive black hole at the Galactic center, one should expect it to be a source of X-ray and gamma-ray activity, behaving basically as a scaled-down active galactic nucleus. An unavoidable source of accretion is the wind from IRS 16, a nearby group of hot, massive stars. Since the density and velocity of the accreting matter are known from observations, the accretion rate is basically a function of the putative black hole mass, M(sub h), only; this value represents a reliable lower limit to a real rate, given the other possible sources of accreting matter. Based on this and on the theories about shock acceleration in active galactic nuclei, we have estimated the expected production of relativistic particles and their hard radiation. These values turn out to be a function of M(sub h) as well. Comparing our results with available X-ray and gamma-ray observations which show Sgr A* to have a relatively low activity level, we conclude tentatively that the putative black hole in the Galactic center cannot have a mass greater than approximately 6 x 10(exp 3) solar mass. This conclusion is consistent with the upper limits to the black hole mass found by different methods earlier, although much more work is needed to make calculations of shock acceleration around black holes more reliable.

Dark matter and pulsar model constraints from Galactic center Fermi/LAT γ-ray observations

NASA Astrophysics Data System (ADS)

Gordon, Chris; Macias, Oscar

2014-05-01

Employing Fermi/LAT γ-ray observations, several independent groups have found excess extended γ-ray emission at the Galactic center (GC). Both, annihilating dark matter (DM) or a population of ~ 103 unresolved millisecond pulsars (MSPs) are regarded as well motivated possible explanations. However, there is significant uncertainties in the diffuse Galactic background at the GC. We have performed a revaluation of these two models for the extended γ-ray source at the GC by accounting for the systematic uncertainties of the Galactic diffuse emission model. We also marginalize over point source and diffuse background parameters in the region of interest. We show that the excess emission is significantly more extended than a point source. We find that the DM (or pulsar population) signal is larger than the systematic errors and therefore proceed to determine the sectors of parameter space that provide an acceptable fit to the data. We found that a population of several thousand MSPs with parameters consistent with the average spectral shape of Fermi/LAT measured MSPs was able to fit the GC excess emission. For DM, we found that a pure τ+τ- annihilation channel is not a good fit to the data. But a mixture of τ+τ- and bb with a <σ v> of order the thermal relic value and a DM mass of around 20 to 60 GeV provides an adequate fit.

Dark matter and pulsar model constraints from Galactic Center Fermi-LAT gamma-ray observations

NASA Astrophysics Data System (ADS)

Gordon, Chris; Macías, Oscar

2013-10-01

Employing Fermi-LAT gamma-ray observations, several independent groups have found excess extended gamma-ray emission at the Galactic Center (GC). Both annihilating dark matter (DM) or a population of ˜103 unresolved millisecond pulsars (MSPs) are regarded as well-motivated possible explanations. However, there are significant uncertainties in the diffuse galactic background at the GC. We have performed a revaluation of these two models for the extended gamma-ray source at the GC by accounting for the systematic uncertainties of the Galactic diffuse emission model. We also marginalize over point-source and diffuse background parameters in the region of interest. We show that the excess emission is significantly more extended than a point source. We find that the DM (or pulsar-population) signal is larger than the systematic errors and therefore proceed to determine the sectors of parameter space that provide an acceptable fit to the data. We find that a population of 1000-2000 MSPs with parameters consistent with the average spectral shape of Fermi-LAT measured MSPs is able to fit the GC excess emission. For DM, we find that a pure τ+τ- annihilation channel is not a good fit to the data. But a mixture of τ+τ- and bb¯ with a ⟨σv⟩ of order the thermal relic value and a DM mass of around 20 to 60 GeV provides an adequate fit.

Analysis Of Ultra Compact Ionized Hydrogen Regions Within The Northern Half Of The Galactic Disk

NASA Astrophysics Data System (ADS)

Bruce, John

2011-01-01

From a catalog of 199 candidate ultra compact (UC) HII regions 123 sources included in the the intersection of the GLIMPSE (8 μm),Cornish (6 cm), and Bolocam ( 1.1 mm) galactic plane surveys (BGPS) were analyzed. The sources were sorted based on 6 cm morphology and coincidence with 8 μm bubbles. The 1.1 mm flux attributes were measured and calculations were performed to determine the ionized hydrogen contributions to the 1.1 mm flux. The category averages and frequencies were obtained as well. Significant differences in HII percentages were present among the morphology groups but ranged widely, without apparent distinction, between the bubble forming and triggered source categories.

KSC01pp0158

NASA Image and Video Library

2001-01-09

Workers in the Spacecraft Assembly & Encapsulation Facility -2 open the solar array panels from the 2001 Mars Odyssey Orbiter, allowing inspection of the panels and giving them access to other components. The Mars Odyssey carries three science instruments: the Thermal Emission Imaging System (THEMIS), the Gamma Ray Spectrometer (GRS), and the Mars Radiation Environment Experiment (MARIE). THEMIS will map the mineralogy and morphology of the Martian surface using a high-resolution camera and a thermal infrared imaging spectrometer. The GRS will achieve global mapping of the elemental composition of the surface and determine the abundance of hydrogen in the shallow subsurface. [The GRS is a rebuild of the instrument lost with the Mars Observer mission.] The MARIE will characterize aspects of the near-space radiation environment as related to the radiation-related risk to human explorers. The Mars Odyssey Orbiter is scheduled for launch on April 7, 2001, aboard a Delta 7925 rocket from Launch Pad 17-A, Cape Canaveral Air Force Station

Feminine transformations: gender reassignment surgical tourism in Thailand.

PubMed

Aizura, Aren Z

2010-10-01

Every year, hundreds of transgendered people from the United States, Europe, Asia, Canada, and Australia travel to Thailand to undergo cosmetic and gender reassignment surgeries (GRS). Many GRS clinics market themselves almost exclusively to non-Thai trans women (people assigned a male sex at birth who later identify as female). This article draws on ethnographic research with patients visiting Thailand for GRS to explore how trans women patients related their experience of medical care in Thailand to Thai cultural traditions, in particular "traditional" Thai femininity and Theravada Buddhist rituals and beliefs. Foreign patients in Thai hospital settings engage not only with medical practices but also with their perceptions of Thai cultural traditions--which inflect their feminine identifications. I draw on two patients' accounts of creating personal rituals to mark their gender reassignment surgery, placing these accounts within the context of biomedical globalization and debates about the touristic appropriation of non-"Western" cultural practices.

Great Red Spot's detection with the Juno gravity experiment

NASA Astrophysics Data System (ADS)

Parisi, M.; Folkner, W. M.

2017-12-01

The Juno spacecraft entered orbit about Jupiter in July 2016. During the perijoves (or closest approaches to Jupiter), Juno carries out observations of the magnetosphere, atmosphere and gravity field of the planet. The gravity field is estimated from precise measurements of the Doppler shift of the Juno radio signal and provides information on the Jovian interior structure.In July 2017 the 7th Juno perijove was over the Great Red Spot. The primary goal was determining differences in ammonia and water abundance in the GRS using the Microwave Radiometer instrument, while Doppler data was acquired acquired on a secondary basis. We present results of analysis of the PJ7 Doppler data to constrain the mass density variations of the GRS relative to the global average. We also present analysis to determine whether future Juno data will provide stronger constraints on the structure of the GRS.

VizieR Online Data Catalog: Einstein EMSS Survey (Gioia+ 1990, Stocke+ 1991)

NASA Astrophysics Data System (ADS)

Gioia, I. M.; Maccacaro, T.; Schild, R. E.; Wolter, A.

1995-07-01

The Einstein Extended Medium Sensitivity Survey (EMSS) consists of 835 serendipitous X-ray sources detected at or above 4 times the rms level in 1435 IPC fields with their centers located away from the galactic plane. Their limiting sensitivities range from ~5*10-14 to to ~ 3*10-12 erg.cm-2.s-1 in the 0.3-3.5keV band. A total area of 778 square degrees of the high galactic latitude sky (|b|>20) has been covered. The analysis has been performed using data from the Rev 1 processing system at the CfA. The resulting EMSS catalog is a flux-limited and homogeneous sample of astronomical objects that can be used for statistical studies. Here we present the table listing all the sources taken from the publication referenced below and the optical identifications. At present over 96% of the 835 X-ray sources have been successfully identified in the following proportions: active galactic nuclei (QSO's, quasars and Seyfert), 51.1%; BL Lacertae objects, 4.3%; clusters of galaxies, 12.2%; normal galaxies, 2.1%; cooling flow galaxies, 0.6%; Galactic stars 25.8%; and unidentified, 3.9%. Most of the individual optical counterparts are previously unknown objects and so constitute large statistical samples independent of previously selection methods. The contents of the table is described below. The sky coverage computed for a specific assumed source spectrum is also given under "Additional Information" below. For further details please see the published articles: Gioia et al. 1990, Stocke et al. 1991. (1 data file).

Generalized Rayleigh scattering. I. Basic theory.

NASA Astrophysics Data System (ADS)

Ivanov, V. V.

1995-11-01

The classsical problem of multiple molecular (in particular, Rayleigh) scattering in plane-parallel atmospheres is considered from a somewhat broader viewpoint than usual. The general approach and ideology are borrowed from non-LTE line formation theory. The main emphasis is on the depth dependence of the corresponding source matrix rather than on the emergent radiation. We study the azimuth-averaged radiation field of polarized radiation in a semi-infinite atmosphere with embedded primary sources. The corresponding 2x2 phase matrix of molecular scattering is P=(1-W) P_I_+W P_R_, where P_I_ and P_R_ are the phase matrices of the scalar isotropic scattering and of the Rayleigh scattering, respectively, and W is the depolarization parameter. Contrary to the usual assumption that W{in}[0,1], we assume W{in} [0,{infinity}) and call this generalized Rayleigh scattering (GRS). Using the factorization of P which is intimately related to its diadic expansion, we reduce the problem to an integral equation for the source matrix S(τ) with a matrix displacement kernel. In operator form this equation is S={LAMBDA}S+S^*^, where {LAMBDA} is the matrix {LAMBDA}-operator and S^*^ is the primary source term. This leads to a new concept, the matrix albedo of single scattering λ =diag(λ_I_,λ_Q_), where λ_I_ is the usual (scalar) single scattering albedo and λ_Q_=0.7Wλ_I_. Its use enables one to formulate matrix equivalents of many of the results of the scalar theory in exactly the same form as in the scalar case. Of crucial importance is the matrix equivalent of the sqrt(ɛ) law of the scalar theory. Another useful new concept is the λ-plane, i.e., the plane with the axes (λ_I_,λ_Q_). Systematic use of the matrix sqrt(ɛ) law and of the λ-plane proved to be a useful instrument in classifying various limiting and particular cases of GRS and in discussing numerical data on the matrix source functions (to be given in Paper II of the series).

X-ray observations of Galactic H.E.S.S. sources: an update

NASA Astrophysics Data System (ADS)

Puehlhofer, G.; Eger, P.; Sasaki, M.; Gottschall, D.; Capasso, M.; H. E. S. S. Collaboration

2016-06-01

X-ray diagnostics of TeV sources continues to be an important tool to identify the nature of newly detected sources as well as to pinpoint the physics processes that are at work in these highly energetic objects. The contribution aims at giving a review of recent studies that we have performed on TeV sources with H.E.S.S. and XMM-Newton and also other X-ray facilities. Here, we will mainly focus on Galactic objects such as gamma-ray binaries, pulsar wind nebulae, and supernova remnants (SNRs). Particular emphasis will be given to SNR studies, including recently identified SNRs such as HESS J1731-347 and HESS J1534-571 as well as a revisit of RX J1713.7-3946.

Cosmic Ray Acceleration from Multiple Galactic Wind Shocks

NASA Astrophysics Data System (ADS)

Cotter, Cory; Bustard, Chad; Zweibel, Ellen

2018-01-01

Cosmic rays still have an unknown origin. Many mechanisms have been suggested for their acceleration including quasars, pulsars, magnetars, supernovae, supernova remnants, and galactic termination shocks. The source of acceleration may be a mixture of these and a different mixture in different energy regimes. Using numerical simulations, we investigate multiple shocks in galactic winds as potential cosmic rays sources. By having shocks closer to the parent galaxy, more particles may diffuse back to the disk instead of being blown out in the wind, as found in Bustard, Zweibel, and Cotter (2017, ApJ) and also Merten, Bustard, Zweibel, and Tjus (to be submitted to ApJ). Specifically, this flux of cosmic rays could contribute to the unexplained "shin" region between the well-known "knee" and "ankle" of the cosmic ray spectrum. We would like to acknowledge support from the National Science Foundation (NSF) Graduate Research Fellowship Program under grant No. DGE-125625 and NSF grant No. AST-1616037.

An observation of the Galactic center hard X-ray source, 1E 1740.7-2942, with the Caltech coded-aperture telescope

NASA Technical Reports Server (NTRS)

Heindl, William A.; Cook, Walter R.; Grunsfeld, John M.; Palmer, David M.; Prince, Thomas A.; Schindler, Stephen M.; Stone, Edward C.

1993-01-01

The Galactic center region hard X-ray source IE 1740.7-2942 has been observed with the Caltech Gamma-Ray Imaging Payload (GRIP) from Alice Springs, Australia, on 1988 April 12 and on 1989 April 3 and 4. We report here results from the 1989 measurements based on 14 hr of observation of the Galactic center region. The observations showed IE 1740.7-2942 to be in its normal state, having a spectrum between 35 and 200 keV characterized by a power law with an exponent of -2.2 +/- 0.3 and flux at 100 keV of (7.0 +/- 0.7) x 10 exp -5 sq cm s keV. No flux was detected above 200 keV. A search for time variability in the spectrum of IE 1740.7-2942 on one hour time scales showed no evidence for variability.

Detection and period measurements of GX1+4 at hard x ray energies with the SIGMA telescope

NASA Technical Reports Server (NTRS)

Laurent, PH.; Salotti, L.; Lebrun, F.; Paul, J.; Denis, M.; Barret, D.; Jourdain, E.; Roques, J. P.; Churazov, E.; Gilfanov, M.

1992-01-01

The galactic Low Mass X ray Binary GX1+4 was detected by the coded aperture hard X ray gamma ray SIGMA telescope during the Feb. to April 1991 observations of the galactic center regions. The source, whose emission varied during the survey of a factor greater than 40 pct., reached a maximum luminosity in the 40 to 140 energy range of 1.03 x 10(exp 37) erg/s (D = 8.5 kpc), thus approaching the emission level of the 1970 to 1980 high state. Two minute flux pulsations were detected on Mar. 22 and on Mar. 31 and Apr. 1. Comparison with the last period measurements shows that the current spin-down phase of GX1+4 is ending. Concerning the proposed association of this source with the galactic center 511 keV annihilation emission, upper limits were derived.

The Southern HII Region Discovery Survey: Preliminary Results

NASA Astrophysics Data System (ADS)

Shea, Jeanine; Wenger, Trey; Balser, Dana S.; Anderson, Loren D.; Armentrout, William P.; Bania, Thomas M.; Dawson, Joanne; Miller Dickey, John; Jordan, Christopher; McClure-Griffiths, Naomi M.

2017-01-01

HII regions are some of the brightest sources at radio frequencies in the Milky Way and are the sites of massive O and B-type star formation. They have relatively short (< 10 Myr) lifetimes compared to other Galactic objects and therefore reveal information about spiral structure and the chemical evolution of the Galaxy. The HII Region Discovery Surveys (HRDS) discovered about 800 new HII regions in the Galactic longitude range -20 degrees to 270 degrees using primarily the Green Bank Telescope. Candidate HII regions were selected from mid-infrared emission coincident with radio continuum emission, and confirmed as HII regions by the detection of radio recombination lines. Here we discuss the Southern HII Region Discovery Survey (SHRDS), a continuation of the HRDS using the Australia Telescope Compact Array over the Galactic longitude range 230 to 360 degrees. We have reduced and analyzed a small sub-set of the SHRDS sources and discuss preliminary results, including kinematic distances and metallicities.

Using the IRAS data to search in the asteroid belt for any potential evidence of galactic colonization

NASA Technical Reports Server (NTRS)

Papagiannis, M. D.

1986-01-01

The end product of the biological evolution seems to be the appearance of technological civilizations, which are characterized by superior technology that supercedes biological capabilities. The Search for Extraterrestrial Intelligence (SETI) has gained scientific recognition in recent years. The concept of galactic colonization is debated extensively, with opinions ranging from the impossible to the inevitable, but without a clear resolution. Answers can be obtained only with experimental tests and not with endless debates. A search for large space colonies in the asteroid belt, an ideal source of raw materials for a spaceborne civilization, is a test of the galactic colonization theory. The catalogue of solar system objects obtained form the Infrared Astronomy Satellite (IRAS) observations at 12, 25, 60, and 100 microns, is an ideal source for such a search. The catalog is expected to be ready at the end of 1985 and will contain more than 10,000 objects.

LOCALIZING INTEGRAL SOURCES WITH CHANDRA: X-RAY AND MULTI-WAVELENGTH IDENTIFICATIONS AND ENERGY SPECTRA

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tomsick, John A.; Bodaghee, Arash; Chaty, Sylvain

2012-08-01

We report on Chandra observations of 18 hard X-ray (>20 keV) sources discovered with the INTEGRAL satellite near the Galactic plane. For 14 of the INTEGRAL sources, we have uncovered one or two potential Chandra counterparts per source. These provide soft X-ray (0.3-10 keV) spectra and subarcsecond localizations, which we use to identify counterparts at other wavelengths, providing information about the nature of each source. Despite the fact that all of the sources are within 5 Degree-Sign of the plane, four of the IGR sources are active galactic nuclei (AGNs; IGR J01545+6437, IGR J15391-5307, IGR J15415-5029, and IGR J21565+5948) andmore » four others are likely AGNs (IGR J03103+5706, IGR J09189-4418, IGR J16413-4046, and IGR J16560-4958) based on each of them having a strong IR excess and/or extended optical or near-IR emission. We compare the X-ray and near-IR fluxes of this group of sources to those of AGNs selected by their 2-10 keV emission in previous studies and find that these IGR AGNs are in the range of typical values. There is evidence in favor of four of the sources being Galactic (IGR J12489-6243, IGR J15293-5609, IGR J16173-5023, and IGR J16206-5253), but only IGR J15293-5609 is confirmed as a Galactic source as it has a unique Chandra counterpart and a parallax measurement from previous optical observations that puts its distance at 1.56 {+-} 0.12 kpc. The 0.3-10 keV luminosity for this source is (1.4{sup +1.0}{sub -0.4}) Multiplication-Sign 10{sup 32} erg s{sup -1}, and its optical/IR spectral energy distribution is well described by a blackbody with a temperature of 4200-7000 K and a radius of 12.0-16.4 R{sub Sun }. These values suggest that IGR J15293-5609 is a symbiotic binary with an early K-type giant and a white dwarf accretor. We also obtained likely Chandra identifications for IGR J13402-6428 and IGR J15368-5102, but follow-up observations are required to constrain their source types.« less

A search for new supernova remnant shells in the Galactic plane with H.E.S.S.

NASA Astrophysics Data System (ADS)

H. E. S. S. Collaboration; Abdalla, H.; Abramowski, A.; Aharonian, F.; Ait Benkhali, F.; Akhperjanian, A. G.; Andersson, T.; Angüner, E. O.; Arakawa, M.; Arrieta, M.; Aubert, P.; Backes, M.; Balzer, A.; Barnard, M.; Becherini, Y.; Becker Tjus, J.; Berge, D.; Bernhard, S.; Bernlöhr, K.; Blackwell, R.; Böttcher, M.; Boisson, C.; Bolmont, J.; Bonnefoy, S.; Bordas, P.; Bregeon, J.; Brun, F.; Brun, P.; Bryan, M.; Büchele, M.; Bulik, T.; Capasso, M.; Carr, J.; Casanova, S.; Cerruti, M.; Chakraborty, N.; Chaves, R. C. G.; Chen, A.; Chevalier, J.; Coffaro, M.; Colafrancesco, S.; Cologna, G.; Condon, B.; Conrad, J.; Cui, Y.; Davids, I. D.; Decock, J.; Degrange, B.; Deil, C.; Devin, J.; deWilt, P.; Dirson, L.; Djannati-Ataï, A.; Domainko, W.; Donath, A.; Drury, L. O.'C.; Dutson, K.; Dyks, J.; Edwards, T.; Egberts, K.; Eger, P.; Ernenwein, J.-P.; Eschbach, S.; Farnier, C.; Fegan, S.; Fernandes, M. V.; Fiasson, A.; Fontaine, G.; Förster, A.; Funk, S.; Füßling, M.; Gabici, S.; Gajdus, M.; Gallant, Y. A.; Garrigoux, T.; Giavitto, G.; Giebels, B.; Glicenstein, J. F.; Gottschall, D.; Goyal, A.; Grondin, M.-H.; Hahn, J.; Haupt, M.; Hawkes, J.; Heinzelmann, G.; Henri, G.; Hermann, G.; Hervet, O.; Hinton, J. A.; Hofmann, W.; Hoischen, C.; Holch, T. L.; Holler, M.; Horns, D.; Ivascenko, A.; Iwasaki, H.; Jacholkowska, A.; Jamrozy, M.; Janiak, M.; Jankowsky, D.; Jankowsky, F.; Jingo, M.; Jogler, T.; Jouvin, L.; Jung-Richardt, I.; Kastendieck, M. A.; Katarzyński, K.; Katsuragawa, M.; Katz, U.; Kerszberg, D.; Khangulyan, D.; Khélifi, B.; King, J.; Klepser, S.; Klochkov, D.; Kluźniak, W.; Kolitzus, D.; Komin, Nu.; Kosack, K.; Krakau, S.; Kraus, M.; Krüger, P. P.; Laffon, H.; Lamanna, G.; Lau, J.; Lees, J.-P.; Lefaucheur, J.; Lefranc, V.; Lemière, A.; Lemoine-Goumard, M.; Lenain, J.-P.; Leser, E.; Lohse, T.; Lorentz, M.; Liu, R.; López-Coto, R.; Lypova, I.; Marandon, V.; Marcowith, A.; Mariaud, C.; Marx, R.; Maurin, G.; Maxted, N.; Mayer, M.; Meintjes, P. J.; Meyer, M.; Mitchell, A. M. W.; Moderski, R.; Mohamed, M.; Mohrmann, L.; Morå, K.; Moulin, E.; Murach, T.; Nakashima, S.; de Naurois, M.; Niederwanger, F.; Niemiec, J.; Oakes, L.; O'Brien, P.; Odaka, H.; Öttl, S.; Ohm, S.; Ostrowski, M.; Oya, I.; Padovani, M.; Panter, M.; Parsons, R. D.; Pekeur, N. W.; Pelletier, G.; Perennes, C.; Petrucci, P.-O.; Peyaud, B.; Piel, Q.; Pita, S.; Poon, H.; Prokhorov, D.; Prokoph, H.; Pühlhofer, G.; Punch, M.; Quirrenbach, A.; Raab, S.; Reimer, A.; Reimer, O.; Renaud, M.; de los Reyes, R.; Richter, S.; Rieger, F.; Romoli, C.; Rowell, G.; Rudak, B.; Rulten, C. B.; Sahakian, V.; Saito, S.; Salek, D.; Sanchez, D. A.; Santangelo, A.; Sasaki, M.; Schlickeiser, R.; Schüssler, F.; Schulz, A.; Schwanke, U.; Schwemmer, S.; Seglar-Arroyo, M.; Settimo, M.; Seyffert, A. S.; Shafi, N.; Shilon, I.; Simoni, R.; Sol, H.; Spanier, F.; Spengler, G.; Spies, F.; Stawarz, Ł.; Steenkamp, R.; Stegmann, C.; Stycz, K.; Sushch, I.; Takahashi, T.; Tavernet, J.-P.; Tavernier, T.; Taylor, A. M.; Terrier, R.; Tibaldo, L.; Tiziani, D.; Tluczykont, M.; Trichard, C.; Tsuji, N.; Tuffs, R.; Uchiyama, Y.; van der Walt, D. J.; van Eldik, C.; van Rensburg, C.; van Soelen, B.; Vasileiadis, G.; Veh, J.; Venter, C.; Viana, A.; Vincent, P.; Vink, J.; Voisin, F.; Völk, H. J.; Vuillaume, T.; Wadiasingh, Z.; Wagner, S. J.; Wagner, P.; Wagner, R. M.; White, R.; Wierzcholska, A.; Willmann, P.; Wörnlein, A.; Wouters, D.; Yang, R.; Zabalza, V.; Zaborov, D.; Zacharias, M.; Zanin, R.; Zdziarski, A. A.; Zech, A.; Zefi, F.; Ziegler, A.; Żywucka, N.; Bamba, A.; Fukui, Y.; Sano, H.; Yoshiike, S.

2018-04-01

A search for new supernova remnants (SNRs) has been conducted using TeV γ-ray data from the H.E.S.S. Galactic plane survey. As an identification criterion, shell morphologies that are characteristic for known resolved TeV SNRs have been used. Three new SNR candidates were identified in the H.E.S.S. data set with this method. Extensive multiwavelength searches for counterparts were conducted. A radio SNR candidate has been identified to be a counterpart to HESS J1534-571. The TeV source is therefore classified as a SNR. For the other two sources, HESS J1614-518 and HESS J1912+101, no identifying counterparts have been found, thus they remain SNR candidates for the time being. TeV-emitting SNRs are key objects in the context of identifying the accelerators of Galactic cosmic rays. The TeV emission of the relativistic particles in the new sources is examined in view of possible leptonic and hadronic emission scenarios, taking the current multiwavelength knowledge into account.

Strong Support for the Millisecond Pulsar Origin of the Galactic Center GeV Excess.

PubMed

Bartels, Richard; Krishnamurthy, Suraj; Weniger, Christoph

2016-02-05

Using γ-ray data from the Fermi Large Area Telescope, various groups have identified a clear excess emission in the Inner Galaxy, at energies around a few GeV. This excess resembles remarkably well a signal from dark-matter annihilation. One of the most compelling astrophysical interpretations is that the excess is caused by the combined effect of a previously undetected population of dim γ-ray sources. Because of their spectral similarity, the best candidates are millisecond pulsars. Here, we search for this hypothetical source population, using a novel approach based on wavelet decomposition of the γ-ray sky and the statistics of Gaussian random fields. Using almost seven years of Fermi-LAT data, we detect a clustering of photons as predicted for the hypothetical population of millisecond pulsar, with a statistical significance of 10.0σ. For plausible values of the luminosity function, this population explains 100% of the observed excess emission. We argue that other extragalactic or Galactic sources, a mismodeling of Galactic diffuse emission, or the thick-disk population of pulsars are unlikely to account for this observation.

Superluminal Motion Found In Milky Way

NASA Astrophysics Data System (ADS)

1994-08-01

Researchers using the Very Large Array (VLA) have discovered that a small, powerful object in our own cosmic neighborhood is shooting out material at nearly the speed of light -- a feat previously known to be performed only by the massive cores of entire galaxies. In fact, because of the direction in which the material is moving, it appears to be traveling faster than the speed of light -- a phenomenon called "superluminal motion." This is the first superluminal motion ever detected within our Galaxy. During March and April of this year, Dr. Felix Mirabel of the Astrophysics Section of the Center for Studies at Saclay, France, and Dr. Luis Rodriguez of the Institute of Astronomy at the National Autonomous University in Mexico City and NRAO, observed "a remarkable ejection event" in which the object shot out material in opposite directions at 92 percent of the speed of light, or more than 171,000 miles per second. This event ejected a mass equal to one-third that of the moon with the power of 100 million suns. Such powerful ejections are well known in distant galaxies and quasars, millions and billions of light-years away, but the object Mirabel and Rodriguez observed is within our own Milky Way Galaxy, only 40,000 light-years away. The object also is much smaller and less massive than the core of a galaxy, so the scientists were quite surprised to find it capable of accelerating material to such speeds. Mirabel and Rodriguez believe that the object is likely a double-star system, with one of the stars either an extremely dense neutron star or a black hole. The neutron star or black hole is the central object of the system, with great mass and strong gravitational pull. It is surrounded by a disk of material orbiting closely and being drawn into it. Such a disk is known as an accretion disk. The central object's powerful gravity, they believe, is pulling material from a more-normal companion star into the accretion disk. The central object is emitting jets of subatomic particles from its poles, and it is in these jets that the rapidly-moving material was tracked. The object, known as GRS 1915+105, also is a strong emitter of X-Rays, sometimes becoming the strongest source of X-Rays in the Milky Way. The X-rays, they think, are emitted from the system's accretion disk. The VLA observations, along with other evidence the researchers have uncovered, leads them to believe that, despite being much less massive than galactic cores, other double-star systems may be capable of ejecting material at speeds near that of light. The researchers reported their discovery in the September 1 issue of the journal Nature. "This discovery is one of the most valuable results of more than a decade and a half of observations at the VLA," said Dr. Miller Goss, assistant director of NRAO for VLA/VLBA operations. "We see these fast-moving jets of material throughout the universe, and they represent an important physical process. However, they're usually so far away that it's difficult to study them. This object, relatively nearby, offers the best opportunity yet to build a good understanding of how such jets actually work," Goss added. GRS 1915+105 was discovered in 1992 by an orbiting French- Russian X-ray observatory called SIGMA-GRANAT. It had not been found before because its X-rays are highly-energetic "hard" X-rays not regularly observed by satellites before then. Since its discovery, it has repeatedly been seen as a source of "hard" X- rays. Despite searching, the scientists have been unable to observe the object in visible light. Observations with the VLA in 1992 and 1993 showed that the object changed both its radio "brightness" and its apparent position in the sky, but it was then too faint at radio wavelengths for precise measurements. In March of 1994, the object began an outburst of strong radio emission just as the VLA had entered a configuration capable of its most precise positional measurements. Through March and April of 1994, Mirabel and Rodriguez were able to track the movement of the two condensations in the jets of material moving away from the object's core. They found that the core remained stationary, while the approaching condensation was apparently moving at 125 percent of the speed of light. After correcting for relativistic effects, they conclude that the ejected material actually is moving at 92 percent of light speed. Their calculations indicate that the pair of "blobs" they tracked were ejected from the core on March 19, during a period when the object was emitting more X-rays than usual. GRS 1915+105 somewhat resembles a famous astronomical object that was intensively studied in the late 1970s and early 1980s, called SS433. The VLA was used for many observations of SS433, which, astronomers believe, is also a double-star system with a dense, massive star as its centerpiece. SS433 has jets similar to those of GRS 1915+105, but the fastest motions detected in SS433's jets are only 26 percent the speed of light. Comparing it to quasars, which are believed to be phenomena associated with supermassive black holes at the centers of galaxies -- objects much larger and more massive than stars -- astronomers have called SS433 a "stellar microquasar." With kinetic energies 40 times those of SS433, GRS 1915+105 "appears to be a scaled up version" of the other object, Mirabel and Rodriguez say.

Growth, carcass characteristics, and profitability of organic versus conventional dairy beef steers.

PubMed

Bjorklund, E A; Heins, B J; Dicostanzo, A; Chester-Jones, H

2014-03-01

Bull calves (n=49), born at the University of Minnesota West Central Research and Outreach Center (Morris) between March and May 2011, were used to compare growth measurements and profitability of conventional and organic dairy steers. Calves were assigned to 1 of 3 replicated groups at birth: conventional (CONV; n=16), organic (pasture and concentrate; ORG; n=16), or organic grass only (GRS; n=17), and analysis of variables was on a pen basis. Breed groups of calves were Holstein (HO; n=9); Holsteins (n=11) maintained at 1964 breed average level; crossbreds (n=19) including combinations of HO, Montbéliarde, and Swedish Red; and crossbreds (n=10) including combinations of HO, Jersey, Swedish Red, and Normande. The CONV steers were fed a diet of 80% concentrate and 20% forage. The ORG steers were fed a diet of organic corn, organic corn silage, and at least 30% of their diet consisted of organic pasture during the grazing season. The GRS steers grazed pasture during the grazing season and were fed high-quality hay or hay silage during the nongrazing season. Intakes of a total mixed ration were recorded daily with herd management software. A profit function was defined to include revenues and expenses for beef value, feed intake, pasture intake, health cost, and yardage. The GRS (358.6 kg) steers had lesser total gains from birth to slaughter than ORG (429.6 kg) and CONV (534.5 kg) steers. Furthermore, the GRS (0.61 kg/d) steers had lesser average daily gain from birth compared with ORG (0.81 kg/d) and CONV (1.1 kg/d) steers. The GRS and ORG steers had smaller rib eye area (49.5 and 65.8 cm(2), respectively) compared with CONV (75.4 cm(2)) steers. For profitability, GRS steers had 43% greater profit than CONV steers due to organic beef price premiums and lower feed costs. On the other hand, ORG steers had substantially less profit than CONV steers. The higher cost of production for the ORG steers is due to the extreme high value of organic corn. The results of the current study illustrate the economic potential of alternative strategies for growing and marketing male offspring of organic dairy cattle in the Midwest. Copyright © 2014 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.

The NuSTAR Hard X-Ray Survey of the Norma Arm Region

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fornasini, Francesca M.; Tomsick, John A.; Chiu, Jeng-Lun

2017-04-01

We present a catalog of hard X-ray sources in a square-degree region surveyed by the Nuclear Spectroscopic Telescope Array ( NuSTAR ) in the direction of the Norma spiral arm. This survey has a total exposure time of 1.7 Ms, and the typical and maximum exposure depths are 50 ks and 1 Ms, respectively. In the area of deepest coverage, sensitivity limits of 5 × 10{sup −14} and 4 × 10{sup −14} erg s{sup −1} cm{sup −2} in the 3–10 and 10–20 keV bands, respectively, are reached. Twenty-eight sources are firmly detected, and 10 are detected with low significance; 8 of the 38 sources are expected tomore » be active galactic nuclei. The three brightest sources were previously identified as a low-mass X-ray binary, high-mass X-ray binary, and pulsar wind nebula. Based on their X-ray properties and multiwavelength counterparts, we identify the likely nature of the other sources as two colliding wind binaries, three pulsar wind nebulae, a black hole binary, and a plurality of cataclysmic variables (CVs). The CV candidates in the Norma region have plasma temperatures of ≈10–20 keV, consistent with the Galactic ridge X-ray emission spectrum but lower than the temperatures of CVs near the Galactic center. This temperature difference may indicate that the Norma region has a lower fraction of intermediate polars relative to other types of CVs compared to the Galactic center. The NuSTAR log N –log S distribution in the 10–20 keV band is consistent with the distribution measured by Chandra at 2–10 keV if the average source spectrum is assumed to be a thermal model with kT  ≈ 15 keV, as observed for the CV candidates.« less

Cosmic ray injection spectrum at the galactic sources

NASA Astrophysics Data System (ADS)

Lagutin, Anatoly; Tyumentsev, Alexander; Volkov, Nikolay

The spectra of cosmic rays measured at Earth are different from their source spectra. A key to understanding this difference, being crucial for solving the problem of cosmic-ray origin, is the determination of how cosmic-ray (CR) particles propagate through the turbulent interstellar medium (ISM). If the medium is a quasi-homogeneous the propagation process can be described by a normal diffusion model. However, during a last few decades many evidences, both from theory and observations, of the existence of multiscale structures in the Galaxy have been found. Filaments, shells, clouds are entities widely spread in the ISM. In such a highly non-homogeneous (fractal-like) ISM the normal diffusion model certainly is not kept valid. Generalization of this model leads to what is known as "anomalous diffusion". The main goal of the report is to retrieve the cosmic ray injection spectrum at the galactic sources in the framework of the anomalous diffusion (AD) model. The anomaly in this model results from large free paths ("Levy flights") of particles between galactic inhomogeneities. In order to evaluate the CR spectrum at the sources, we carried out new calculation of the CR spectra at Earth. AD equation in terms of fractional derivatives have been used to describe CR propagation from the nearby (r≤1 kpc) young (t≤ 1 Myr) and multiple old distant (r > 1 kpc) sources. The assessment of the key model parameters have been based on the results of the particles diffusion in the cosmic and laboratory plasma. We show that in the framework of the anomalous diffusion model the locally observed basic features of the cosmic rays (difference between spectral exponents of proton, He and other nuclei, "knee" problem, positron to electron ratio) can be explained if the injection spectrum at the main galactic sources of cosmic rays has spectral exponent p˜ 2.85. The authors acknowledge support from The Russian Foundation for Basic Research grant No. 14-02-31524.

Topics in gamma ray astronomy

NASA Technical Reports Server (NTRS)

Ramaty, R.; Lingenfelter, R. E.

1986-01-01

Observations of gamma rays from solar flares, gamma ray bursts, the Galactic center, galactic nucleosynthesis, SS433, and Cygnus X-3, and their effects on astrophysical problems are discussed. It is observed that gamma ray spectra from solar flares are applicable to the study of particle acceleration and confinement and the determination of chemical abundances in the solar atmosphere. The gamma ray lines from the compact galactic object SS433 are utilized to examine the acceleration of jets, and analysis of the gamma ray lines of Cygnus X-3 reveal that particles can be accelerated in compact sources to ultrahigh energies.

Asymmetric 511 keV Positron Annihilation Line Emission from the Inner Galactic Disk

NASA Technical Reports Server (NTRS)

Skinner, Gerry; Weidenspointner, Georg; Jean, Pierre; Knodlseder, Jurgen; Ballmoos, Perer von; Bignami, Giovanni; Diehl, Roland; Strong, Andrew; Cordier, Bertrand; Schanne, Stephane;

Joint effect of unlinked genotypes: application to type 2 diabetes in the EPIC-Potsdam case-cohort study.

PubMed

Knüppel, Sven; Meidtner, Karina; Arregui, Maria; Holzhütter, Hermann-Georg; Boeing, Heiner

2015-07-01

Analyzing multiple single nucleotide polymorphisms (SNPs) is a promising approach to finding genetic effects beyond single-locus associations. We proposed the use of multilocus stepwise regression (MSR) to screen for allele combinations as a method to model joint effects, and compared the results with the often used genetic risk score (GRS), conventional stepwise selection, and the shrinkage method LASSO. In contrast to MSR, the GRS, conventional stepwise selection, and LASSO model each genotype by the risk allele doses. We reanalyzed 20 unlinked SNPs related to type 2 diabetes (T2D) in the EPIC-Potsdam case-cohort study (760 cases, 2193 noncases). No SNP-SNP interactions and no nonlinear effects were found. Two SNP combinations selected by MSR (Nagelkerke's R² = 0.050 and 0.048) included eight SNPs with mean allele combination frequency of 2%. GRS and stepwise selection selected nearly the same SNP combinations consisting of 12 and 13 SNPs (Nagelkerke's R² ranged from 0.020 to 0.029). LASSO showed similar results. The MSR method showed the best model fit measured by Nagelkerke's R² suggesting that further improvement may render this method a useful tool in genetic research. However, our comparison suggests that the GRS is a simple way to model genetic effects since it does not consider linkage, SNP-SNP interactions, and no non-linear effects. © 2015 John Wiley & Sons Ltd/University College London.

Genetic variation of habitual coffee consumption and glycemic changes in response to weight-loss diet intervention: the Preventing Overweight Using Novel Dietary Strategies (POUNDS LOST) trial.

PubMed

Han, Liyuan; Ma, Wenjie; Sun, Dianjianyi; Heianza, Yoriko; Wang, Tiange; Zheng, Yan; Huang, Tao; Duan, Donghui; Bray, J George A; Champagne, Catherine M; Sacks, Frank M; Qi, Lu

2017-11-01

Background: Coffee consumption has been associated with glucose metabolism and risk of type 2 diabetes. Objective: We examined whether the genetic variation determining habitual coffee consumption affected glycemic changes in response to weight-loss dietary intervention. Design: A genetic risk score (GRS) was calculated based on 8 habitual coffee consumption-associated single nucleotide polymorphisms. We used general linear models to test changes in glycemic traits in groups randomly assigned to high- and low-fat diets according to tertiles of the GRS. Results: We observed significant interactions between the GRS and low compared with high dietary fat intake on 6-mo changes in fasting insulin and homeostasis model assessment of insulin resistance (HOMA-IR) ( P -interaction = 0.023 and 0.022, respectively), adjusting for age, sex, race, physical activity, smoking, alcohol, seasonal variation, and baseline values of the respective outcomes. Participants with a higher GRS of habitual coffee consumption showed a greater reduction in fasting insulin and a marginally greater decrease in HOMA-IR in the low-fat diet intervention group. Conclusions: Our data suggest that participants with genetically determined high coffee consumption may benefit more by eating a low-fat diet in improving fasting insulin and HOMA-IR in a short term. This trial was registered at clinicaltrials.gov as NCT00072995 and NCT03258203. © 2017 American Society for Nutrition.

The ISOGAL survey

NASA Astrophysics Data System (ADS)

Omont, A.; ISOGAL Collaboration

1999-03-01

ISOGAL is a 7-15 μm ISOCAM survey, with 6'' pixels and sensitivity below 10 mJy, of ~20 deg2, in the galactic plane mostly interior to |l| = 30o. In combination with KJI DENIS data, the ISO images allow detailed studies of cold stellar populations and galactic structures in regions highly obscured throughout the inner Galaxy, with a sensitivity and pixel surface two orders of magnitude better than IRAS. Data reduction is particularly difficult because of the high density of strong sources, of memory effects and of short integration times. However, an improved data reduction is almost complete for all the fields observed, with the use of CIA ISOCAM software and of a special source extraction. The data quality is acceptable, as concerns reliability, completeness and photometric accuracy of the sources, to allow a systematic scientific analysis. A few fields, in the bulge and in the galactic disk, exemplify the results expected from the ~200 fields observed. These results include: A complete census of mass-losing AGB stars in fields of the inner bulge. Even very weak mass-loss are very well characterised, down to the RGB tip. Such stars are by far the most numerous there. They form a very well defined sequence in ISOGAL-DENIS infrared colour-magnitude diagrams. The knowledge of Long Period Variables in two Baade's Window fields confirm that their luminosity is just above the tip of this sequence, and that the spectral type of the stars of the sequence is M6-9III. The same AGB sequence is also quite visible in 7-15 μm colour-magnitude diagrams in the galactic disk, even with a very large extinction. Such AGB stars are thus particularly numerous among the ~105 sources detected by ISOGAL. However, foreground red giants and dusty young stars are also quite numerous. The latter with a few solar masses are detectable through the galactic centre distance. A number of bright young stars are identified on lines of sight close to the Galactic Centre, The combination of ISOGAL and DENIS data allows a detailed estimate of the interstellar extinction for individual stars and lines of sight. Many dark globules and filaments are visible on the 7 and 15 μm images, corresponding to visible extinction larger than ~20-30. The very rich structure of the mid-infrared diffuse emission is often clearly associated with stars.

Acceleration of petaelectronvolt protons in the Galactic Centre

NASA Astrophysics Data System (ADS)

HESS Collaboration; Abramowski, A.; Aharonian, F.; Benkhali, F. Ait; Akhperjanian, A. G.; Angüner, E. O.; Backes, M.; Balzer, A.; Becherini, Y.; Tjus, J. Becker; Berge, D.; Bernhard, S.; Bernlöhr, K.; Birsin, E.; Blackwell, R.; Böttcher, M.; Boisson, C.; Bolmont, J.; Bordas, P.; Bregeon, J.; Brun, F.; Brun, P.; Bryan, M.; Bulik, T.; Carr, J.; Casanova, S.; Chakraborty, N.; Chalme-Calvet, R.; Chaves, R. C. G.; Chen, A.; Chrétien, M.; Colafrancesco, S.; Cologna, G.; Conrad, J.; Couturier, C.; Cui, Y.; Davids, I. D.; Degrange, B.; Deil, C.; Dewilt, P.; Djannati-Ataï, A.; Domainko, W.; Donath, A.; Drury, L. O'C.; Dubus, G.; Dutson, K.; Dyks, J.; Dyrda, M.; Edwards, T.; Egberts, K.; Eger, P.; Ernenwein, J.-P.; Espigat, P.; Farnier, C.; Fegan, S.; Feinstein, F.; Fernandes, M. V.; Fernandez, D.; Fiasson, A.; Fontaine, G.; Förster, A.; Füßling, M.; Gabici, S.; Gajdus, M.; Gallant, Y. A.; Garrigoux, T.; Giavitto, G.; Giebels, B.; Glicenstein, J. F.; Gottschall, D.; Goyal, A.; Grondin, M.-H.; Grudzińska, M.; Hadasch, D.; Häffner, S.; Hahn, J.; Hawkes, J.; Heinzelmann, G.; Henri, G.; Hermann, G.; Hervet, O.; Hillert, A.; Hinton, J. A.; Hofmann, W.; Hofverberg, P.; Hoischen, C.; Holler, M.; Horns, D.; Ivascenko, A.; Jacholkowska, A.; Jamrozy, M.; Janiak, M.; Jankowsky, F.; Jung-Richardt, I.; Kastendieck, M. A.; Katarzyński, K.; Katz, U.; Kerszberg, D.; Khélifi, B.; Kieffer, M.; Klepser, S.; Klochkov, D.; Kluźniak, W.; Kolitzus, D.; Komin, Nu.; Kosack, K.; Krakau, S.; Krayzel, F.; Krüger, P. P.; Laffon, H.; Lamanna, G.; Lau, J.; Lefaucheur, J.; Lefranc, V.; Lemiére, A.; Lemoine-Goumard, M.; Lenain, J.-P.; Lohse, T.; Lopatin, A.; Lu, C.-C.; Lui, R.; Marandon, V.; Marcowith, A.; Mariaud, C.; Marx, R.; Maurin, G.; Maxted, N.; Mayer, M.; Meintjes, P. J.; Menzler, U.; Meyer, M.; Mitchell, A. M. W.; Moderski, R.; Mohamed, M.; Morå, K.; Moulin, E.; Murach, T.; de Naurois, M.; Niemiec, J.; Oakes, L.; Odaka, H.; Öttl, S.; Ohm, S.; Opitz, B.; Ostrowski, M.; Oya, I.; Panter, M.; Parsons, R. D.; Arribas, M. Paz; Pekeur, N. W.; Pelletier, G.; Petrucci, P.-O.; Peyaud, B.; Pita, S.; Poon, H.; Prokoph, H.; Pühlhofer, G.; Punch, M.; Quirrenbach, A.; Raab, S.; Reichardt, I.; Reimer, A.; Reimer, O.; Renaud, M.; de Los Reyes, R.; Rieger, F.; Romoli, C.; Rosier-Lees, S.; Rowell, G.; Rudak, B.; Rulten, C. B.; Sahakian, V.; Salek, D.; Sanchez, D. A.; Santangelo, A.; Sasaki, M.; Schlickeiser, R.; Schüssler, F.; Schulz, A.; Schwanke, U.; Schwemmer, S.; Seyffert, A. S.; Simoni, R.; Sol, H.; Spanier, F.; Spengler, G.; Spies, F.; Stawarz, Ł.; Steenkamp, R.; Stegmann, C.; Stinzing, F.; Stycz, K.; Sushch, I.; Tavernet, J.-P.; Tavernier, T.; Taylor, A. M.; Terrier, R.; Tluczykont, M.; Trichard, C.; Tuffs, R.; Valerius, K.; van der Walt, J.; van Eldik, C.; van Soelen, B.; Vasileiadis, G.; Veh, J.; Venter, C.; Viana, A.; Vincent, P.; Vink, J.; Voisin, F.; Völk, H. J.; Vuillaume, T.; Wagner, S. J.; Wagner, P.; Wagner, R. M.; Weidinger, M.; Weitzel, Q.; White, R.; Wierzcholska, A.; Willmann, P.; Wörnlein, A.; Wouters, D.; Yang, R.; Zabalza, V.; Zaborov, D.; Zacharias, M.; Zdziarski, A. A.; Zech, A.; Zefi, F.; Żywucka, N.

2016-03-01

Galactic cosmic rays reach energies of at least a few petaelectronvolts (of the order of 1015 electronvolts). This implies that our Galaxy contains petaelectronvolt accelerators (‘PeVatrons’), but all proposed models of Galactic cosmic-ray accelerators encounter difficulties at exactly these energies. Dozens of Galactic accelerators capable of accelerating particles to energies of tens of teraelectronvolts (of the order of 1013 electronvolts) were inferred from recent γ-ray observations. However, none of the currently known accelerators—not even the handful of shell-type supernova remnants commonly believed to supply most Galactic cosmic rays—has shown the characteristic tracers of petaelectronvolt particles, namely, power-law spectra of γ-rays extending without a cut-off or a spectral break to tens of teraelectronvolts. Here we report deep γ-ray observations with arcminute angular resolution of the region surrounding the Galactic Centre, which show the expected tracer of the presence of petaelectronvolt protons within the central 10 parsecs of the Galaxy. We propose that the supermassive black hole Sagittarius A* is linked to this PeVatron. Sagittarius A* went through active phases in the past, as demonstrated by X-ray outburstsand an outflow from the Galactic Centre. Although its current rate of particle acceleration is not sufficient to provide a substantial contribution to Galactic cosmic rays, Sagittarius A* could have plausibly been more active over the last 106-107 years, and therefore should be considered as a viable alternative to supernova remnants as a source of petaelectronvolt Galactic cosmic rays.

A Targeted Search for Point Sources of EeV Neutrons

NASA Astrophysics Data System (ADS)

Aab, A.; Abreu, P.; Aglietta, M.; Ahlers, M.; Ahn, E. J.; Samarai, I. Al; Albuquerque, I. F. M.; Allekotte, I.; Allen, J.; Allison, P.; Almela, A.; Alvarez Castillo, J.; Alvarez-Muñiz, J.; Alves Batista, R.; Ambrosio, M.; Aminaei, A.; Anchordoqui, L.; Andringa, S.; Aramo, C.; Arqueros, F.; Asorey, H.; Assis, P.; Aublin, J.; Ave, M.; Avenier, M.; Avila, G.; Badescu, A. M.; Barber, K. B.; Bäuml, J.; Baus, C.; Beatty, J. J.; Becker, K. H.; Bellido, J. A.; Berat, C.; Bertou, X.; Biermann, P. L.; Billoir, P.; Blanco, F.; Blanco, M.; Bleve, C.; Blümer, H.; Boháčová, M.; Boncioli, D.; Bonifazi, C.; Bonino, R.; Borodai, N.; Brack, J.; Brancus, I.; Brogueira, P.; Brown, W. C.; Buchholz, P.; Bueno, A.; Buscemi, M.; Caballero-Mora, K. S.; Caccianiga, B.; Caccianiga, L.; Candusso, M.; Caramete, L.; Caruso, R.; Castellina, A.; Cataldi, G.; Cazon, L.; Cester, R.; Chavez, A. G.; Cheng, S. H.; Chiavassa, A.; Chinellato, J. A.; Chudoba, J.; Cilmo, M.; Clay, R. W.; Cocciolo, G.; Colalillo, R.; Collica, L.; Coluccia, M. R.; Conceição, R.; Contreras, F.; Cooper, M. J.; Coutu, S.; Covault, C. E.; Criss, A.; Cronin, J.; Curutiu, A.; Dallier, R.; Daniel, B.; Dasso, S.; Daumiller, K.; Dawson, B. R.; de Almeida, R. M.; De Domenico, M.; de Jong, S. J.; de Mello Neto, J. R. T.; De Mitri, I.; de Oliveira, J.; de Souza, V.; del Peral, L.; Deligny, O.; Dembinski, H.; Dhital, N.; Di Giulio, C.; Di Matteo, A.; Diaz, J. C.; Díaz Castro, M. L.; Diep, P. N.; Diogo, F.; Dobrigkeit, C.; Docters, W.; D'Olivo, J. C.; Dong, P. N.; Dorofeev, A.; Dova, M. T.; Ebr, J.; Engel, R.; Erdmann, M.; Erfani, M.; Escobar, C. O.; Espadanal, J.; Etchegoyen, A.; Facal San Luis, P.; Falcke, H.; Fang, K.; Farrar, G.; Fauth, A. C.; Fazzini, N.; Ferguson, A. P.; Fernandes, M.; Fick, B.; Figueira, J. M.; Filevich, A.; Filipčič, A.; Fox, B. D.; Fratu, O.; Fröhlich, U.; Fuchs, B.; Fuji, T.; Gaior, R.; García, B.; Garcia Roca, S. T.; Garcia-Gamez, D.; Garcia-Pinto, D.; Garilli, G.; Gascon Bravo, A.; Gate, F.; Gemmeke, H.; Ghia, P. L.; Giaccari, U.; Giammarchi, M.; Giller, M.; Glaser, C.; Glass, H.; Gomez Albarracin, F.; Gómez Berisso, M.; Gómez Vitale, P. F.; Gonçalves, P.; Gonzalez, J. G.; Gookin, B.; Gorgi, A.; Gorham, P.; Gouffon, P.; Grebe, S.; Griffith, N.; Grillo, A. F.; Grubb, T. D.; Guardincerri, Y.; Guarino, F.; Guedes, G. P.; Hansen, P.; Harari, D.; Harrison, T. A.; Harton, J. L.; Hasankiadeh, Q. D.; Haungs, A.; Hebbeker, T.; Heck, D.; Heimann, P.; Herve, A. E.; Hill, G. C.; Hojvat, C.; Hollon, N.; Holt, E.; Homola, P.; Hörandel, J. R.; Horvath, P.; Hrabovský, M.; Huber, D.; Huege, T.; Insolia, A.; Isar, P. G.; Islo, K.; Jandt, I.; Jansen, S.; Jarne, C.; Josebachuili, M.; Kääpä, A.; Kambeitz, O.; Kampert, K. H.; Kasper, P.; Katkov, I.; Kégl, B.; Keilhauer, B.; Keivani, A.; Kemp, E.; Kieckhafer, R. M.; Klages, H. O.; Kleifges, M.; Kleinfeller, J.; Krause, R.; Krohm, N.; Krömer, O.; Kruppke-Hansen, D.; Kuempel, D.; Kunka, N.; La Rosa, G.; LaHurd, D.; Latronico, L.; Lauer, R.; Lauscher, M.; Lautridou, P.; Le Coz, S.; Leão, M. S. A. B.; Lebrun, D.; Lebrun, P.; Leigui de Oliveira, M. A.; Letessier-Selvon, A.; Lhenry-Yvon, I.; Link, K.; López, R.; Lopez Agüera, A.; Louedec, K.; Lozano Bahilo, J.; Lu, L.; Lucero, A.; Ludwig, M.; Lyberis, H.; Maccarone, M. C.; Malacari, M.; Maldera, S.; Maller, J.; Mandat, D.; Mantsch, P.; Mariazzi, A. G.; Marin, V.; Mariş, I. C.; Marsella, G.; Martello, D.; Martin, L.; Martinez, H.; Martínez Bravo, O.; Martraire, D.; Masías Meza, J. J.; Mathes, H. J.; Mathys, S.; Matthews, A. J.; Matthews, J.; Matthiae, G.; Maurel, D.; Maurizio, D.; Mayotte, E.; Mazur, P. O.; Medina, C.; Medina-Tanco, G.; Melissas, M.; Melo, D.; Menichetti, E.; Menshikov, A.; Messina, S.; Meyhandan, R.; Mićanović, S.; Micheletti, M. I.; Middendorf, L.; Minaya, I. A.; Miramonti, L.; Mitrica, B.; Molina-Bueno, L.; Mollerach, S.; Monasor, M.; Monnier Ragaigne, D.; Montanet, F.; Morello, C.; Moreno, J. C.; Mostafá, M.; Moura, C. A.; Muller, M. A.; Müller, G.; Münchmeyer, M.; Mussa, R.; Navarra, G.; Navas, S.; Necesal, P.; Nellen, L.; Nelles, A.; Neuser, J.; Niechciol, M.; Niemietz, L.; Niggemann, T.; Nitz, D.; Nosek, D.; Novotny, V.; Nožka, L.; Ochilo, L.; Olinto, A.; Oliveira, M.; Ortiz, M.; Pacheco, N.; Pakk Selmi-Dei, D.; Palatka, M.; Pallotta, J.; Palmieri, N.; Papenbreer, P.; Parente, G.; Parra, A.; Pastor, S.; Paul, T.; Pech, M.; Peķala, J.; Pelayo, R.; Pepe, I. M.; Perrone, L.; Pesce, R.; Petermann, E.; Peters, C.; Petrera, S.; Petrolini, A.; Petrov, Y.; Piegaia, R.; Pierog, T.; Pieroni, P.; Pimenta, M.; Pirronello, V.; Platino, M.; Plum, M.; Porcelli, A.; Porowski, C.; Privitera, P.; Prouza, M.; Purrello, V.; Quel, E. J.; Querchfeld, S.; Quinn, S.; Rautenberg, J.; Ravel, O.; Ravignani, D.; Revenu, B.; Ridky, J.; Riggi, S.; Risse, M.; Ristori, P.; Rizi, V.; Roberts, J.; Rodrigues de Carvalho, W.; Rodriguez Cabo, I.; Rodriguez Fernandez, G.; Rodriguez Rojo, J.; Rodríguez-Frías, M. D.; Ros, G.; Rosado, J.; Rossler, T.; Roth, M.; Roulet, E.; Rovero, A. C.; Rühle, C.; Saffi, S. J.; Saftoiu, A.; Salamida, F.; Salazar, H.; Salesa Greus, F.; Salina, G.; Sánchez, F.; Sanchez-Lucas, P.; Santo, C. E.; Santos, E.; Santos, E. M.; Sarazin, F.; Sarkar, B.; Sarmento, R.; Sato, R.; Scharf, N.; Scherini, V.; Schieler, H.; Schiffer, P.; Schmidt, A.; Scholten, O.; Schoorlemmer, H.; Schovánek, P.; Schulz, A.; Schulz, J.; Sciutto, S. J.; Segreto, A.; Settimo, M.; Shadkam, A.; Shellard, R. C.; Sidelnik, I.; Sigl, G.; Sima, O.; Śmiałkowski, A.; Šmída, R.; Snow, G. R.; Sommers, P.; Sorokin, J.; Squartini, R.; Srivastava, Y. N.; Stanič, S.; Stapleton, J.; Stasielak, J.; Stephan, M.; Stutz, A.; Suarez, F.; Suomijärvi, T.; Supanitsky, A. D.; Sutherland, M. S.; Swain, J.; Szadkowski, Z.; Szuba, M.; Taborda, O. A.; Tapia, A.; Tartare, M.; Thao, N. T.; Theodoro, V. M.; Tiffenberg, J.; Timmermans, C.; Todero Peixoto, C. J.; Toma, G.; Tomankova, L.; Tomé, B.; Tonachini, A.; Torralba Elipe, G.; Torres Machado, D.; Travnicek, P.; Trovato, E.; Tueros, M.; Ulrich, R.; Unger, M.; Urban, M.; Valdés Galicia, J. F.; Valiño, I.; Valore, L.; van Aar, G.; van den Berg, A. M.; van Velzen, S.; van Vliet, A.; Varela, E.; Vargas Cárdenas, B.; Varner, G.; Vázquez, J. R.; Vázquez, R. A.; Veberič, D.; Verzi, V.; Vicha, J.; Videla, M.; Villaseñor, L.; Vlcek, B.; Wahlberg, H.; Wainberg, O.; Walz, D.; Watson, A. A.; Weber, M.; Weidenhaupt, K.; Weindl, A.; Werner, F.; Whelan, B. J.; Widom, A.; Wiencke, L.; Wilczyńska, B.; Wilczyński, H.; Will, M.; Williams, C.; Winchen, T.; Wittkowski, D.; Wundheiler, B.; Wykes, S.; Yamamoto, T.; Yapici, T.; Younk, P.; Yuan, G.; Yushkov, A.; Zamorano, B.; Zas, E.; Zavrtanik, D.; Zavrtanik, M.; Zaw, I.; Zepeda, A.; Zhou, J.; Zhu, Y.; Zimbres Silva, M.; Ziolkowski, M.; Auger Collaboration101, The Pierre

2014-07-01

A flux of neutrons from an astrophysical source in the Galaxy can be detected in the Pierre Auger Observatory as an excess of cosmic-ray air showers arriving from the direction of the source. To avoid the statistical penalty for making many trials, classes of objects are tested in combinations as nine "target sets," in addition to the search for a neutron flux from the Galactic center or from the Galactic plane. Within a target set, each candidate source is weighted in proportion to its electromagnetic flux, its exposure to the Auger Observatory, and its flux attenuation factor due to neutron decay. These searches do not find evidence for a neutron flux from any class of candidate sources. Tabulated results give the combined p-value for each class, with and without the weights, and also the flux upper limit for the most significant candidate source within each class. These limits on fluxes of neutrons significantly constrain models of EeV proton emission from non-transient discrete sources in the Galaxy.

Observations of low-luminosity X-ray sources in Vela-Puppis

NASA Technical Reports Server (NTRS)

Pravdo, S. H.; Becker, R. H.; Boldt, E. A.; Holt, S. S.; Serlemitsos, P. J.; Swank, J. H.

1978-01-01

Results are presented for a study of the X-ray emission from a small portion of the galactic plane near galactic longitude 260 deg. This region contains at least six low-luminosity X-ray sources within about 10 deg of PSR 0833-45, which is near the center of the Gum nebula. The X-ray source 4U 0833-45, associated with the Vela pulsar, is observed at twice its 4U catalog intensity. The lack of X-ray pulsations at the pulsar period (greater than 99% nonpulsed), the nonthermal power-law spectrum, and models of the X-ray source distribution in this region suggest that a large fraction of the X-rays come from an extended source about 1 deg of arc in radius. The observation of a high-temperature (effective temperature at least 100 million K) spectrum in a field of view containing only Puppis A among known sources has led to the discovery of new OSO 8 source, OS 0752-39. Other spectra from this region are discussed.

Chandra Observation of the X-ray Source Population of NGC 6946

NASA Technical Reports Server (NTRS)

Holt, S. S.; Schlegel, E. M.; Hwang, U.; Petre, R.

2003-01-01

We present the results of a study of discrete X-ray sources in NGC 6946 using a deep Chandra ACIS observation. Based on the slope of the log N-log S distribution and the general correlation of sources with the spiral arms, we infer that the overall discrete source sample in NGC 6946 is dominated by high mass X-ray binaries, in contrast to the source distributions in M31 and the Milky Way. This is consistent with the higher star formation rate in NGC 6946 than in those galaxies. We find that the strong X-ray sources in the region of the galactic center do not correlate in detail with images of the region in the near-IR, although one of them may be coincident with the galactic center. The non-central ultra-luminous X-ray source in NGC 6946, previously identified with a supernova remnant, has an X-ray spectrum and luminosity that is inconsistent with either a traditional pulsar wind nebula or a blast wave remnant.

Galactic supernova remnant candidates discovered by THOR

NASA Astrophysics Data System (ADS)

Anderson, L. D.; Wang, Y.; Bihr, S.; Rugel, M.; Beuther, H.; Bigiel, F.; Churchwell, E.; Glover, S. C. O.; Goodman, A. A.; Henning, Th.; Heyer, M.; Klessen, R. S.; Linz, H.; Longmore, S. N.; Menten, K. M.; Ott, J.; Roy, N.; Soler, J. D.; Stil, J. M.; Urquhart, J. S.

2017-09-01

Context. There is a considerable deficiency in the number of known supernova remnants (SNRs) in the Galaxy compared to that expected. This deficiency is thought to be caused by a lack of sensitive radio continuum data. Searches for extended low-surface brightness radio sources may find new Galactic SNRs, but confusion with the much larger population of H II regions makes identifying such features challenging. SNRs can, however, be separated from H II regions using their significantly lower mid-infrared (MIR) to radio continuum intensity ratios. Aims: Our goal is to find missing SNR candidates in the Galactic disk by locating extended radio continuum sources that lack MIR counterparts. Methods: We use the combination of high-resolution 1-2 GHz continuum data from The HI, OH, Recombination line survey of the Milky Way (THOR) and lower-resolution VLA 1.4 GHz Galactic Plane Survey (VGPS) continuum data, together with MIR data from the Spitzer GLIMPSE, Spitzer MIPSGAL, and WISE surveys to identify SNR candidates. To ensure that the candidates are not being confused with H II regions, we exclude radio continuum sources from the WISE Catalog of Galactic H II Regions, which contains all known and candidate H II regions in the Galaxy. Results: We locate 76 new Galactic SNR candidates in the THOR and VGPS combined survey area of 67.4° > ℓ > 17.5°, | b | ≤ 1.25° and measure the radio flux density for 52 previously-known SNRs. The candidate SNRs have a similar spatial distribution to the known SNRs, although we note a large number of new candidates near ℓ ≃ 30°, the tangent point of the Scutum spiral arm. The candidates are on average smaller in angle compared to the known regions, 6.4' ± 4.7' versus 11.0' ± 7.8', and have lower integrated flux densities. Conclusions: The THOR survey shows that sensitive radio continuum data can discover a large number of SNR candidates, and that these candidates can be efficiently identified using the combination of radio and MIR data. If the 76 candidates are confirmed as true SNRs, for example using radio polarization measurements or by deriving radio spectral indices, this would more than double the number of known Galactic SNRs in the survey area. This large increase would still, however, leave a discrepancy between the known and expected SNR populations of about a factor of two.

HESS observations of the galactic center region and their possible dark matter interpretation.

PubMed

Aharonian, F; Akhperjanian, A G; Bazer-Bachi, A R; Beilicke, M; Benbow, W; Berge, D; Bernlöhr, K; Boisson, C; Bolz, O; Borrel, V; Braun, I; Breitling, F; Brown, A M; Bühler, R; Büsching, I; Carrigan, S; Chadwick, P M; Chounet, L-M; Cornils, R; Costamante, L; Degrange, B; Dickinson, H J; Djannati-Ataï, A; Drury, L O'C; Dubus, G; Egberts, K; Emmanoulopoulos, D; Espigat, P; Feinstein, F; Ferrero, E; Fiasson, A; Fontaine, G; Funk, Seb; Funk, S; Gallant, Y A; Giebels, B; Glicenstein, J F; Goret, P; Hadjichristidis, C; Hauser, D; Hauser, M; Heinzelmann, G; Henri, G; Hermann, G; Hinton, J A; Hofmann, W; Holleran, M; Horns, D; Jacholkowska, A; de Jager, O C; Khélifi, B; Komin, Nu; Konopelko, A; Kosack, K; Latham, I J; Le Gallou, R; Lemière, A; Lemoine-Goumard, M; Lohse, T; Martin, J M; Martineau-Huynh, O; Marcowith, A; Masterson, C; McComb, T J L; de Naurois, M; Nedbal, D; Nolan, S J; Noutsos, A; Orford, K J; Osborne, J L; Ouchrif, M; Panter, M; Pelletier, G; Pita, S; Pühlhofer, G; Punch, M; Raubenheimer, B C; Raue, M; Rayner, S M; Reimer, A; Reimer, O; Ripken, J; Rob, L; Rolland, L; Rowell, G; Sahakian, V; Saugé, L; Schlenker, S; Schlickeiser, R; Schwanke, U; Sol, H; Spangler, D; Spanier, F; Steenkamp, R; Stegmann, C; Superina, G; Tavernet, J-P; Terrier, R; Théoret, C G; Tluczykont, M; van Eldik, C; Vasileiadis, G; Venter, C; Vincent, P; Völk, H J; Wagner, S J; Ward, M

2006-12-01

The detection of gamma rays from the source HESS J1745-290 in the Galactic Center (GC) region with the High Energy Spectroscopic System (HESS) array of Cherenkov telescopes in 2004 is presented. After subtraction of the diffuse gamma-ray emission from the GC ridge, the source is compatible with a point source with spatial extent less than 1.2;{'}(stat) (95% C.L.). The measured energy spectrum above 160 GeV is compatible with a power law with photon index of 2.25+/-0.04(stat)+/-0.10(syst) and no significant flux variation is detected. It is finally found that the bulk of the very high energy emission must have non-dark-matter origin.

The EVN Galactic Plane Survey - EGaPS

NASA Technical Reports Server (NTRS)

Petrov, Leonid

2011-01-01

I present a catalogue of the positions and correlated flux densities of 109 compact extragalactic radio sources in the Galactic plane determined from an analysis of a 48-h Very Long Baseline Interferometry (VLBI) experiment at 22 GHz with the European VLBI Network. The median position uncertainty is 9 mas. The correlated flux densities of the detected sources are in the range of 2-300 mJy. In addition to the target sources, nine water masers have been detected, of which two are new. I derived the positions of the masers with an accuracy of 30-200 mas and determined the velocities of the maser components and their correlated flux densities. The catalogue and the supporting material are available at http://astrogeo.org/egaps.

Relations of long-term and contemporary lipid levels and lipid genetic risk scores with coronary artery calcium in the framingham heart study.

PubMed

Tsao, Connie W; Preis, Sarah Rosner; Peloso, Gina M; Hwang, Shih-Jen; Kathiresan, Sekar; Fox, Caroline S; Cupples, L Adrienne; Hoffmann, Udo; O'Donnell, Christopher J

2012-12-11

This study evaluated the association of timing of lipid levels and lipid genetic risk score (GRS) with subclinical atherosclerosis. Atherosclerosis is a slowly progressive disorder influenced by suboptimal lipid levels. Long-term versus contemporary lipid levels may more strongly impact the development of coronary artery calcium (CAC). Framingham Heart Study (FHS) Offspring Cohort participants (n = 1,156, 44% male, 63 ± 9 years) underwent serial fasting lipids (low-density lipoprotein cholesterol [LDL-C], high-density lipoprotein, and triglycerides), Exam 1 (1971 to 1975) to Exam 7 (1998 to 2001). FHS Third Generation Cohort participants (n = 1,954, 55% male, 45 ± 6 years) had fasting lipid profiles assessed, 2002 to 2005. Computed tomography (2002 to 2005) measured CAC. Lipid GRSs were computed from significantly associated single-nucleotide polymorphisms. The association between early, long-term average, and contemporary lipids, and lipid GRS with elevated CAC was assessed using logistic regression. In FHS Offspring, Exam 1 and long-term average as compared with Exam 7 lipid measurements, including untreated lipid levels, were strongly associated with elevated CAC. In the FHS Third Generation, contemporary lipids were associated with CAC. The LDL-C GRS was associated with CAC (age-/sex-adjusted odds ratio: 1.14, 95% confidence interval: 1.00 to 1.29, p = 0.04). However, addition of the GRS to the lipid models did not result in a significant increase in the odds ratio or C-statistic for any lipid measure. Early and long-term average lipid levels, as compared with contemporary measures, are more strongly associated with elevated CAC. Lipid GRS was associated with lipid levels but did not predict elevated CAC. Adult early and long-term average lipid levels provide important information when assessing subclinical atherosclerosis and cardiovascular risk. Copyright © 2012 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.

Spinal glucocorticoid receptor‑regulated chronic morphine tolerance may be through extracellular signal‑regulated kinase 1/2.

PubMed

Zhai, Mei-Li; Chen, Yi; Liu, Chong; Wang, Jian-Bo; Yu, Yong-Hao

2018-05-23

Opioid use has been limited in the treatment of chronic pain due to their side effects, including analgesic tolerance. Previous studies demonstrated that glucocorticoid receptors (GRs) may be involved in the development of chronic morphine tolerance; however, the mechanism remains unknown. It was hypothesized that the expression of spinal phosphorylated mitogen‑activated protein kinase [MAPK; phosphorylated extracellular signal‑regulated kinase (ERK)] is regulated through the spinal GRs, following chronic treatment with morphine. In the first experiment, the experimental rats were randomly divided into four groups: Control, morphine, morphine+GR antagonist mifepristone (RU38486) and morphine+GR agonist dexamethasone (Dex). Each group was treated with continuous intrathecal (IT) injection of the drugs for 6 days. The expression of GRs and MAPK 3/1 (p‑ERK 1/2) in the spinal dorsal horn was detected by western blot analysis and immunofluorescence staining. In the second experiment, the MAPK inhibitor PD98059 was added and the rats were randomly divided into four groups: Control, morphine, PD98059+morphine and PD98059+morphine+Dex. The continuous IT injection lasted for 7 days in each group. For all experiments, the tail flick test was conducted 30 min following administration every day to assess the thermal hyperalgesia of the rats. The experimental results demonstrated that there was a co‑existence of GRs and p‑ERK 1/2 in the spinal cord dorsal horn by double immunofluorescence staining. The GR antagonist RU38486 attenuated the morphine analgesia tolerance by inhibiting the expression of GR and increasing the expression of p‑ERK. The MAPK inhibitor PD98059 increased the effect of morphine tolerance and prolonged the duration of morphine tolerance. The present results suggest that spinal GRs may serve an important role in the development of morphine tolerance through the ERK signaling pathway.

Optimizing logistics for balloon-occluded retrograde transvenous obliteration (BRTO) of gastric varices by doing away with the indwelling balloon: concept and techniques.

PubMed

Saad, Wael E; Nicholson, David B

2013-06-01

Since the conception of balloon-occluded retrograde transvenous obliteration (BRTO) of gastric varices 25 years ago, the placement of an indwelling balloon for hours has been central to the BRTO procedure. Numerous variables and variations of the BRTO procedure have been described, including methods to reduce sclerosant, combining percutaneous transhepatic obliteration, varying sclerosant, and using multiple sclerosants within the same procedure. However, the consistent feature of BRTO has always remained the indwelling balloon. Placing an indwelling balloon over hours for the BRTO procedure is a logistical burden that taxes the interventional radiology team and hospital resources. Substituting the balloon with hardware (coils or Amplatzer vascular plugs [AVPs] or both) is technically feasible and its risks most likely correlate with gastrorenal shunt (GRS) size. The current authors use packed 0.018- or 0.035-in coils or both for small gastric variceal systems (GRS size A and B) and AVPs for GRS sizes up to size E (from size A-E). The current authors recommend an indwelling balloon (no hardware substitute) for very large gastric variceal system (GRS size F). Substituting the indwelling balloon for hardware in size F and potentially size E GRS can also be risky. The current article describes the techniques of placing up to 16-mm AVPs through balloon occlusion guide catheters and then deflating the balloon once it has been substituted with the AVPs. In addition, 22-mm AVPs can be placed through sheaths once the balloon occlusion catheters are removed to further augment the 16-mm Amplatzer occlusion. To date, there are no studies describing, let alone evaluating, the clinical feasibility of performing BRTO without indwelling balloons. The described techniques have been successfully performed by the current authors. However, the long-term safety and effectiveness of these techniques is yet to be determined. Copyright © 2013 Elsevier Inc. All rights reserved.

Lead-Related Genetic Loci, Cumulative Lead Exposure and Incident Coronary Heart Disease: The Normative Aging Study

PubMed Central

Weisskopf, Marc G.; Sparrow, David; Schwartz, Joel; Hu, Howard; Park, Sung Kyun

2016-01-01

Background Cumulative exposure to lead is associated with cardiovascular outcomes. Polymorphisms in the δ-aminolevulinic acid dehydratase (ALAD), hemochromatosis (HFE), heme oxygenase-1 (HMOX1), vitamin D receptor (VDR), glutathione S-transferase (GST) supergene family (GSTP1, GSTT1, GSTM1), apolipoprotein E (APOE),angiotensin II receptor-1 (AGTR1) and angiotensinogen (AGT) genes, are believed to alter toxicokinetics and/or toxicodynamics of lead. Objectives We assessed possible effect modification by genetic polymorphisms in ALAD, HFE, HMOX1, VDR, GSTP1, GSTT1, GSTM1, APOE, AGTR1 and AGT individually and as the genetic risk score (GRS) on the association between cumulative lead exposure and incident coronary heart disease (CHD) events. Methods We used K-shell-X-ray fluorescence to measure bone lead levels. GRS was calculated on the basis of 22 lead-related loci. We constructed Cox proportional hazard models to compute adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for incident CHD. We applied inverse probability weighting to account for potential selection bias due to recruitment into the bone lead sub-study. Results Significant effect modification was found by VDR, HMOX1, GSTP1, APOE, and AGT genetic polymorphisms when evaluated individually. Further, the bone lead-CHD associations became larger as GRS increases. After adjusting for potential confounders, a HR of CHD was 2.27 (95%CI: 1.50–3.42) with 2-fold increase in patella lead levels, among participants in the top tertile of GRS. We also detected an increasing trend in HRs across tertiles of GRS (p-trend = 0.0063). Conclusions Our findings suggest that lead-related loci as a whole may play an important role in susceptibility to lead-related CHD risk. These findings need to be validated in a separate cohort containing bone lead, lead-related genetic loci and incident CHD data. PMID:27584680

Genetic Predictors of Cardiovascular Mortality During Intensive Glycemic Control in Type 2 Diabetes: Findings From the ACCORD Clinical Trial.

PubMed

Shah, Hetal S; Gao, He; Morieri, Mario Luca; Skupien, Jan; Marvel, Skylar; Paré, Guillaume; Mannino, Gaia C; Buranasupkajorn, Patinut; Mendonca, Christine; Hastings, Timothy; Marcovina, Santica M; Sigal, Ronald J; Gerstein, Hertzel C; Wagner, Michael J; Motsinger-Reif, Alison A; Buse, John B; Kraft, Peter; Mychaleckyj, Josyf C; Doria, Alessandro

2016-11-01

To identify genetic determinants of increased cardiovascular mortality among subjects with type 2 diabetes who underwent intensive glycemic therapy in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial. A total of 6.8 million common variants were analyzed for genome-wide association with cardiovascular mortality among 2,667 self-reported white subjects in the ACCORD intensive treatment arm. Significant loci were examined in the entire ACCORD white genetic dataset (n = 5,360) for their modulation of cardiovascular responses to glycemic treatment assignment and in a Joslin Clinic cohort (n = 422) for their interaction with long-term glycemic control on cardiovascular mortality. Two loci, at 10q26 and 5q13, attained genome-wide significance as determinants of cardiovascular mortality in the ACCORD intensive arm (P = 9.8 × 10 -9 and P = 2 × 10 -8 , respectively). A genetic risk score (GRS) defined by the two variants was a significant modulator of cardiovascular mortality response to treatment assignment in the entire ACCORD white genetic dataset. Participants with GRS = 0 experienced a fourfold reduction in cardiovascular mortality in response to intensive treatment (hazard ratio [HR] 0.24 [95% CI 0.07-0.86]), those with GRS = 1 experienced no difference (HR 0.92 [95% CI 0.54-1.56]), and those with GRS ≥2 experienced a threefold increase (HR 3.08 [95% CI 1.82-5.21]). The modulatory effect of the GRS on the association between glycemic control and cardiovascular mortality was confirmed in the Joslin cohort (P = 0.029). Two genetic variants predict the cardiovascular effects of intensive glycemic control in ACCORD. Further studies are warranted to determine whether these findings can be translated into new strategies to prevent cardiovascular complications of diabetes. © 2016 by the American Diabetes Association.

Genetic Predictors of Cardiovascular Mortality During Intensive Glycemic Control in Type 2 Diabetes: Findings From the ACCORD Clinical Trial

PubMed Central

Shah, Hetal S.; Gao, He; Morieri, Mario Luca; Skupien, Jan; Marvel, Skylar; Paré, Guillaume; Mannino, Gaia C.; Buranasupkajorn, Patinut; Mendonca, Christine; Hastings, Timothy; Marcovina, Santica M.; Sigal, Ronald J.; Gerstein, Hertzel C.; Wagner, Michael J.; Motsinger-Reif, Alison A.; Buse, John B.; Kraft, Peter; Mychaleckyj, Josyf C.

2016-01-01

OBJECTIVE To identify genetic determinants of increased cardiovascular mortality among subjects with type 2 diabetes who underwent intensive glycemic therapy in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial. RESEARCH DESIGN AND METHODS A total of 6.8 million common variants were analyzed for genome-wide association with cardiovascular mortality among 2,667 self-reported white subjects in the ACCORD intensive treatment arm. Significant loci were examined in the entire ACCORD white genetic dataset (n = 5,360) for their modulation of cardiovascular responses to glycemic treatment assignment and in a Joslin Clinic cohort (n = 422) for their interaction with long-term glycemic control on cardiovascular mortality. RESULTS Two loci, at 10q26 and 5q13, attained genome-wide significance as determinants of cardiovascular mortality in the ACCORD intensive arm (P = 9.8 × 10−9 and P = 2 × 10−8, respectively). A genetic risk score (GRS) defined by the two variants was a significant modulator of cardiovascular mortality response to treatment assignment in the entire ACCORD white genetic dataset. Participants with GRS = 0 experienced a fourfold reduction in cardiovascular mortality in response to intensive treatment (hazard ratio [HR] 0.24 [95% CI 0.07–0.86]), those with GRS = 1 experienced no difference (HR 0.92 [95% CI 0.54–1.56]), and those with GRS ≥2 experienced a threefold increase (HR 3.08 [95% CI 1.82–5.21]). The modulatory effect of the GRS on the association between glycemic control and cardiovascular mortality was confirmed in the Joslin cohort (P = 0.029). CONCLUSIONS Two genetic variants predict the cardiovascular effects of intensive glycemic control in ACCORD. Further studies are warranted to determine whether these findings can be translated into new strategies to prevent cardiovascular complications of diabetes. PMID:27527847

New look on the origin of cosmic rays

NASA Astrophysics Data System (ADS)

Istomin, Ya. N.

2017-06-01

From the analysis of the flux of high energy particles, E > 3 · 1018 eV, it is shown that the distribution of the power density of extragalactic rays over energy is of the power law, q̅(E) ∝ E-2.7, with the same index of 2.7 that has the distribution of Galactic cosmic rays before the so called `knee', E < 3 · 1015 eV. However, the average power of extragalactic sources, which is of ɛ ≃ 1043 erg s-1, exceeds by at least two orders the power emitted by the Galaxy in cosmic rays, assuming that the density of galaxies is estimated as Ng ≃ 1 Mpc-3. Considering that such power can be provided by relativistic jets from active galactic nuclei with the power ɛ ≃ 1045 - 1046 erg s-1, we estimate the density of extragalactic sources of cosmic rays as Ng ≃ 10-2 - 10-3 Mpc-3. Assuming the same nature of Galactic and extragalactic rays, we conclude that the Galactic rays were produced by a relativistic jet emitted from the Galactic center during the period of its activity in the past. The remnants of a bipolar jet are now observed in the form of bubbles of relativistic gas above and below the Galactic plane. The break, observed in the spectrum of Galactic rays (`knee'), is explained by fast escape of energetic particles, E > 3 · 1015 eV, from the Galaxy because of the dependence of the coefficient of diffusion of cosmic rays on energy, D∝E0.7. The obtained index of the density distribution of particles over energy, N(E)∝E-2.7-0.7/2=E-3.05, for E > 3 · 1015 eV agrees well with the observed one, N(E)∝E-3.1. The estimated time of the termination of the jet in the Galaxy is 4.2 · 104 years ago.

The Gaia-ESO Survey: Lithium enrichment histories of the Galactic thick and thin disc

NASA Astrophysics Data System (ADS)

Fu, X.; Romano, D.; Bragaglia, A.; Mucciarelli, A.; Lind, K.; Delgado Mena, E.; Sousa, S. G.; Randich, S.; Bressan, A.; Sbordone, L.; Martell, S.; Korn, A. J.; Abia, C.; Smiljanic, R.; Jofré, P.; Pancino, E.; Tautvaišienė, G.; Tang, B.; Magrini, L.; Lanzafame, A. C.; Carraro, G.; Bensby, T.; Damiani, F.; Alfaro, E. J.; Flaccomio, E.; Morbidelli, L.; Zaggia, S.; Lardo, C.; Monaco, L.; Frasca, A.; Donati, P.; Drazdauskas, A.; Chorniy, Y.; Bayo, A.; Kordopatis, G.

2018-02-01

Lithium abundance in most of the warm metal-poor main sequence stars shows a constarnt plateau (A(Li) 2.2 dex) and then the upper envelope of the lithium vs. metallicity distribution increases as we approach solar metallicity. Meteorites, which carry information about the chemical composition of the interstellar medium (ISM) at the solar system formation time, show a lithium abundance A(Li) 3.26 dex. This pattern reflects the Li enrichment history of the ISM during the Galaxy lifetime. After the initial Li production in big bang nucleosynthesis, the sources of the enrichment include asymptotic giant branch (AGB) stars, low-mass red giants, novae, type II supernovae, and Galactic cosmic rays. The total amount of enriched Li is sensitive to the relative contribution of these sources. Thus different Li enrichment histories are expected in the Galactic thick and thin disc. We investigate the main sequence stars observed with UVES in Gaia-ESO Survey iDR4 catalogue and find a Li-anticorrelation independent of [Fe/H], Teff, and log(g). Since in stellar evolution different α enhancements at the same metallicity do not lead to a measurable Li abundance change, the anticorrelation indicates that more Li is produced during the Galactic thin disc phase than during the Galactic thick disc phase. We also find a correlation between the abundance of Li and s-process elements Ba and Y, and they both decrease above the solar metallicity, which can be explained in the framework of the adopted Galactic chemical evolution models. The full Table 1 is only available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (http://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/610/A38

The IRAS minisurvey. [Infra Red Astronomy Satellite study of selected sources

NASA Technical Reports Server (NTRS)

Rowan-Robinson, M.; Clegg, P. E.; Emerson, J. P.; Beichman, C. A.; Aumann, H. H.; Gautier, T. N.; Neugebauer, G.; Soifer, B. T.; Beintema, D. A.; Boggess, N.

1984-01-01

Before the main Infrared Astronomical Satellite (IRAS) all-sky survey was started, a preliminary survey of 900 sq deg was carried out. Some results from this 'minisurvey' are given here. The completeness of the minisurvey at galactic latitudes from 20 to 40 deg drops sharply at flux densities below 0.4, 0.4, 0.5, and 2.5 Jy at 12, 25, 60, and 100 microns, respectively. The corresponding surface densities of point sources brighter than these flux levels are 1.1, 0.4, 0.65, and 1.25/sq deg, respectively. Outside the galactic plane, the majority of the sources at 12 and 25 microns are stars, while galaxies make up a significant proportion of 60 micron sources. The 100 micron band is dominated by emission from interstellar dust over much of the minisurvey area.

Five Years of the Fermi LAT Flare Advocate

NASA Astrophysics Data System (ADS)

Carpenter, Bryce; Ojha, R.; Gasparrini, D.; Ciprini, S.; Fermi LAT Collaboration; Fermi LAT Flare Advocates

2014-01-01

Since the launch of the Fermi satellite, the Fermi Large Area Telescope (LAT) team has run a program that provides a daily review of the the gamma-ray sky as soon as Fermi LAT data becomes available. The Flare Advocate/Gamma-ray Sky Watcher (FA-GSW) program allows a rapid analysis of the Automatic Science Processing (ASP) products and triggers dedicated followup analyses by several LAT science groups such as those studying Galactic transients, extragalactic sources and new gamma-ray sources. Significant gamma-ray detections also trigger rapid communications to the entire astrophysical community via astronomical telegrams and gamma-ray coordination network notices. The FA-GSW program plays a key role in maximizing the science return from Fermi by increasing the rate of multi-frequency observations of sources in an active gamma-ray state. In the past ~5 years blazar flaring activity of varying strength and duty cycles, gravitationally lensed blazars, flares from Galactic sources (like Nova Delphini and the Crab Nebula), unidentified transients near and off the Galactic plane, and emission from the quiet and flaring Sun, represent the range of detections made. Flare Advocates have published about 250 Astronomical Telegrams and they publish a weekly blog. Timely, extensive multi-frequency campaigns have been organized to follow-up on these phenomena leading to some of Fermi’s most interesting results.

100y DASCH Search for historical outbursts of Black Hole Low Mass X-ray Binaries

NASA Astrophysics Data System (ADS)

Grindlay, Jonathan E.; Miller, George; Gomez, Sebastian

2018-01-01

Black Hole Low mass X-ray binaries (BH-LMXBs) are all transients, although several (e.g. GRS1915+109 and GX339-4) are quasi-persistent. All of the now 22 dynamically confirmed BH-LMXBs were discovered by their luminous outbursts, reaching Lx ~10^37 ergs/s, with outburst durations of typically ~1-3 months. These systems then (with few exceptions) return to a deep quiescent state, with Lx reduced by factors ~10^5-6 and hard X-ray spectra. The X-ray outbursts are accompanied by optical outbursts (if not absorbed by Galactic extinction) with ~6-9 magnitude increases and similar lightcurve shapes and durations as the X-ray (discovery) outburst. Prior to this work, only 3 BH-LMXBs have had historical (before the X-ray discovery) outbursts found in the archival data: A0620-00, the first BH-LMXB to be so identified, V404 Cyg (discoverd as "Nova Cyg" in 1938 and regarded as a classical nova), and V4641-Sgr which was given its variable star name when first noted in 1975. We report on the historical outbursts now discovered from the DASCH (Digital Access to a Sky Century @ Harvard) data from scanning and digitizing the now ~210,000 glass plates in the northern Galactic Hemisphere. This was one of the primary motivations for the DASCH project: to use the detection (or lack threof) of historic outbursts to measure or constrain the Duty Cycle of the accreting black holes in these systems. This, in turn, allows the total population of BH-LMXBs to be estimated and compared with that for the very similar systems containing neutron stars as the accretor (NS-LMXBs). Whereas the ratio of BHs/NSs from stellar evolution and IMFs is expected to be <<1, the DASCH results on half the sky point to an excess of BH-LMXBs. This must constrain the formation process for these systems, of importance for understanding both BH formation and compact binary evolution.

Consistency between the luminosity function of resolved millisecond pulsars and the galactic center excess

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ploeg, Harrison; Gordon, Chris; Crocker, Roland

Fermi Large Area Telescope data reveal an excess of GeV gamma rays from the direction of the Galactic Center and bulge. Several explanations have been proposed for this excess including an unresolved population of millisecond pulsars (MSPs) and self-annihilating dark matter. It has been claimed that a key discriminant for or against the MSP explanation can be extracted from the properties of the luminosity function describing this source population. Specifically, is the luminosity function of the putative MSPs in the Galactic Center consistent with that characterizing the resolved MSPs in the Galactic disk? To investigate this we have used amore » Bayesian Markov Chain Monte Carlo to evaluate the posterior distribution of the parameters of the MSP luminosity function describing both resolved MSPs and the Galactic Center excess. At variance with some other claims, our analysis reveals that, within current uncertainties, both data sets can be well fit with the same luminosity function.« less

Determination of Galactic Aberration from VLBI Measurements and Its Effect on VLBI Reference Frames and Earth Orientation Parameters.

NASA Astrophysics Data System (ADS)

MacMillan, D. S.

2014-12-01

Galactic aberration is due to the motion of the solar system barycenter around the galactic center. It results in a systematic pattern of apparent proper motion of radio sources observed by VLBI. This effect is not currently included in VLBI analysis. Estimates of the size of this effect indicate that it is important that this secular aberration drift be accounted for in order to maintain an accurate celestial reference frame and allow astrometry at the several microarcsecond level. Future geodetic observing systems are being designed to be capable of producing a future terrestrial reference frame with an accuracy of 1 mm and stability of 0.1 mm/year. We evaluate the effect galactic aberration on attaining these reference frame goals. This presentation will discuss 1) the estimation of galactic aberration from VLBI data and 2) the effect of aberration on the Terrestrial and Celestial Reference Frames and the Earth Orientation Parameters that connect these frames.

Primary gamma rays. [resulting from cosmic ray interaction with interstellar matter

NASA Technical Reports Server (NTRS)

Fichtel, C. E.

1974-01-01

Within this galaxy, cosmic rays reveal their presence in interstellar space and probably in source regions by their interactions with interstellar matter which lead to gamma rays with a very characteristic energy spectrum. From the study of the intensity of the high energy gamma radiation as a function of galactic longitude, it is already clear that cosmic rays are almost certainly not uniformly distributed in the galaxy and are not concentrated in the center of the galaxy. The galactic cosmic rays appear to be tied to galactic structural features, presumably by the galactic magnetic fields which are in turn held by the matter in the arm segments and the clouds. On the extragalactic scale, it is now possible to say that cosmic rays are not universal at the density seen near the earth. The diffuse celestial gamma ray spectrum that is observed presents the interesting possibility of cosmological studies and possible evidence for a residual universal cosmic ray density, which is much lower than the present galactic cosmic ray density.

The DECam Plane Survey: Optical photometry of two billion objects in the southern Galactic plane

NASA Astrophysics Data System (ADS)

Schlafly, Edward; Green, Gregory M.; Lang, Dustin; Daylan, Tansu; Finkbeiner, Douglas; Lee, Albert; Meisner, Aaron; Schlegel, David; Valdes, Francisco

2018-01-01

The DECam Plane Survey is a five-band optical and near-infrared survey of the southern Galactic plane with the Dark Energy Camera at Cerro Tololo. The survey is designed to reach past the main-sequence turn-off at the distance of the Galactic center through a reddening E(B-V) of 1.5 mag. Typical single-exposure depths are 23.7, 22.8, 22.3, 21.9, and 21.0 mag in the grizY bands, with seeing around 1 arcsecond. The footprint covers the Galactic plane with |b| < 4°, 5° > l > -120°. The survey pipeline simultaneously solves for the positions and fluxes of tens of thousands of sources in each image, delivering positions and fluxes of roughly two billion stars with better than 10 mmag precision. Most of these objects are highly reddened and deep in the Galactic disk, probing the structure and properties of the Milky Way and its interstellar medium. The full survey is publicly available.

Highly Strong and Elastic Graphene Fibres Prepared from Universal Graphene Oxide Precursors

PubMed Central

Huang, Guoji; Hou, Chengyi; Shao, Yuanlong; Wang, Hongzhi; Zhang, Qinghong; Li, Yaogang; Zhu, Meifang

2014-01-01

Graphene fibres are continuously prepared from universal graphene oxide precursors by a novel hydrogel-assisted spinning method. With assistance of a rolling process, meters of ribbon-like GFs, or GRs with improved conductivity, tensile strength, and a long-range ordered compact layer structure are successfully obtained. Furthermore, we refined our spinning process to obtained elastic GRs with a mixing microstructure and exceptional elasticity, which may provide a platform for electronic skins and wearable electronics, sensors, and energy devices. PMID:24576869

Identifications of Four Integral Sources in the Galactic Plane via CHANDRA Localizations

NASA Technical Reports Server (NTRS)

Tomsick, John A.; Chaty, Sylvain; Rodriquez, Jerome; Foschini, Luigi; Walter, Roland; Kaaret, Philip

2006-01-01

Hard X-ray imaging of the Galactic plane by the INTEGRAL satellite is uncovering large numbers of 20-100 keV "IGR" sources. We present results from Chandra, INTEGRAL, optical, and IR observations of four IGR sources: three sources in the Norma region of the Galaxy(1GR J16195-4945,IGR J16207-5129, and IGR J16167-4957) and one that is closer to the Galactic center (IGR 5171 95-4100). In all four cases, one relatively bright Chandra source is seen in the INTEGRAL error circle, and these are likely to be the soft X-ray counterparts of the IGR sources. They have hard 0.3-10 keV spectra with power-law photon indices of Gamma = 0.5-1.1. While many previously studied IGR sources show high column densities (NH approx. 10(exp 23)-10(exp 24)/sq cm), only IGR J16195-4945 has a column density that could be as high as 10(exp 23)/sq cm. Using optical and IR sky survey catalogs and our own photometry, we have obtained identifications for all four sources. The J-band magnitudes are in the range 14.9-10.4, and we have used the optical/IR spectral energy distributions (SEDs) to constrain the nature of the sources. Blackbody components with temperature lower limits of >9400 K for IGR J16195-4945 and >18,000 K for IGR J16207-5129 indicate that these are very likely high-mass X-ray binaries (HMXBs). However, for IGR 516167-4957 and IGR J17195-4100, low extinction and the SEDs indicate later spectral types for the putative companions, suggesting that these are not HMXBs.

Tests and consequences of disk plus halo models of gamma-ray burst sources

NASA Technical Reports Server (NTRS)

Smith, I. A.

1995-01-01

The gamma-ray burst observations made by the Burst and Transient Source Experiment (BATSE) and by previous experiments are still consistent with a combined Galactic disk (or Galactic spiral arm) plus extended Galactic halo model. Testable predictions and consequences of the disk plus halo model are discussed here; tests performed on the expanded BATSE database in the future will constrain the allowed model parameters and may eventually rule out the disk plus halo model. Using examples, it is shown that if the halo has an appropriate edge, BATSE will never detect an anisotropic signal from the halo of the Andromeda galaxy. A prediction of the disk plus halo model is that the fraction of the bursts observed to be in the 'disk' population rises as the detector sensitivity improves. A careful reexamination of the numbers of bursts in the two populations for the pre-BATSE databases could rule out this class of models. Similarly, it is predicted that different satellites will observe different relative numbers of bursts in the two classes for any model in which there are two different spatial distribiutions of the sources, or for models in which there is one spatial distribution of the sources that is sampled to different depths for the two classes. An important consequence of the disk plus halo model is that for the birthrate of the halo sources to be small compared to the birthrate of the disk sources, it is necessary for the halo sources to release many orders of magnitude more energy over their bursting lifetime than the disk sources. The halo bursts must also be much more luminous than the disk bursts; if this disk-halo model is correct, it is necessary to explain why the disk sources do not produce halo-type bursts.

Overall properties of the Gaia DR1 reference frame

NASA Astrophysics Data System (ADS)

Liu, N.; Zhu, Z.; Liu, J.-C.; Ding, C.-Y.

2017-03-01

Aims: The first Gaia data release (Gaia DR1) provides 2191 ICRF2 sources with their positions in the auxiliary quasar solution and five astrometric parameters - positions, parallaxes, and proper motions - for stars in common between the Tycho-2 catalogue and Gaia in the joint Tycho-Gaia astrometric solution (TGAS). We aim to analyze the overall properties of Gaia DR1 reference frame. Methods: We compare quasar positions of the auxiliary quasar solution with ICRF2 sources using different samples and evaluate the influence on the Gaia DR1 reference frame owing to the Galactic aberration effect over the J2000.0-J2015.0 period. Then we estimate the global rotation between TGAS with Tycho-2 proper motion systems to investigate the property of the Gaia DR1 reference frame. Finally, the Galactic kinematics analysis using the K-M giant proper motions is performed to understand the property of Gaia DR1 reference frame. Results: The positional comparison between the auxiliary quasar solution and ICRF2 shows negligible orientation and validates the declination bias of -0.1mas in Gaia quasar positions with respect to ICRF2. Galactic aberration effect is thought to cause an offset 0.01mas of the Z axis direction of Gaia DR1 reference frame. The global rotation between TGAS and Tycho-2 proper motion systems, obtained by different samples, shows a much smaller value than the claimed value 0.24mas yr-1. For the Galactic kinematics analysis of the TGAS K-M giants, we find possible non-zero Galactic rotation components beyond the classical Oort constants: the rigid part ωYG = -0.38±0.15mas yr-1 and the differential part ω^primeYG = -0.29±0.19mas yr-1 around the YG axis of Galactic coordinates, which indicates possible residual rotation in Gaia DR1 reference frame or problems in the current Galactic kinematical model. Conclusions: The Gaia DR1 reference frame is well aligned to ICRF2, and the possible influence of the Galactic aberration effect should be taken into consideration for the future Gaia-ICRF link. The cause of the rather small global rotation between TGAS and Tycho-2 proper motion systems is unclear and needs further investigation. The possible residual rotation in Gaia DR1 reference frame inferred from the Galactic kinematic analysis should be noted and examined in future data release.

The Propagation of Cosmic Rays from the Galactic Wind Termination Shock: Back to the Galaxy?

NASA Astrophysics Data System (ADS)

Merten, Lukas; Bustard, Chad; Zweibel, Ellen G.; Becker Tjus, Julia

2018-05-01

Although several theories exist for the origin of cosmic rays (CRs) in the region between the spectral “knee” and “ankle,” this problem is still unsolved. A variety of observations suggest that the transition from Galactic to extragalactic sources occurs in this energy range. In this work, we examine whether a Galactic wind that eventually forms a termination shock far outside the Galactic plane can contribute as a possible source to the observed flux in the region of interest. Previous work by Bustard et al. estimated that particles can be accelerated to energies above the “knee” up to R max = 1016 eV for parameters drawn from a model of a Milky Way wind. A remaining question is whether the accelerated CRs can propagate back into the Galaxy. To answer this crucial question, we simulate the propagation of the CRs using the low-energy extension of the CRPropa framework, based on the solution of the transport equation via stochastic differential equations. The setup includes all relevant processes, including three-dimensional anisotropic spatial diffusion, advection, and corresponding adiabatic cooling. We find that, assuming realistic parameters for the shock evolution, a possible Galactic termination shock can contribute significantly to the energy budget in the “knee” region and above. We estimate the resulting produced neutrino fluxes and find them to be below measurements from IceCube and limits by KM3NeT.

High-Energy Cosmic Ray Self-Confinement Close to Extra-Galactic Sources.

PubMed

Blasi, Pasquale; Amato, Elena; D'Angelo, Marta

2015-09-18

The ultrahigh-energy cosmic rays observed on the Earth are most likely accelerated in extra-Galactic sources. For the typical luminosities invoked for such sources, the electric current associated to the flux of cosmic rays that leave them is large. The associated plasma instabilities create magnetic fluctuations that can efficiently scatter particles. We argue that this phenomenon forces cosmic rays to be self-confined in the source proximity for energies E

A search for TeV gamma-ray emission from SNRs, pulsars and unidentified GeV sources in the Galactic plane in the longitude range between -2 deg and 85 deg.

NASA Astrophysics Data System (ADS)

Aharonian, F. A.; Akhperjanian, A. G.; Beilicke, M.; Bernloehr, K.; Bojahr, H.; Bolz, O.; Boerst, H.; Coarasa, T.; Contreras, J. L.; Cortina, J.; Denninghoff, S.; Fonseca, V.; Girma, M.; Goetting, N.; Heinzelmann, G.; Hermann, G.; Heusler, A.; Hofmann, W.; Horns, D.; Jung, I.; Kankanyan, R.; Kestel, M.; Kettler, J.; Kohnle, A.; Konopelko, A.; Kornmeyer, H.; Kranich, D.; Krawczynski, H.; Lampeitl, H.; Lopez, M.; Lorenz, E.; Lucarelli, F.; Mang, O.; Meyer, H.; Mirzoyan, R.; Moralejo, A.; Ona, E.; Panter, M.; Plyasheshnikov, A.; Puehlhofer, G.; Rauterberg, G.; Reyes, R.; Rhode, W.; Ripken, J.; Roehring, A.; Rowell, G. P.; Sahakian, V.; Samorski, M.; Schilling, M.; Siems, M.; Sobzynska, D.; Stamm, W.; Tluczykont, M.; Voelk, H. J.; Wiedner, C. A.; Wittek, W.

2002-12-01

Using the HEGRA system of imaging atmospheric Cherenkov telescopes, one quarter of the Galactic plane (-2o < l < 85o) was surveyed for TeV gamma-ray emission from point sources and moderately extended sources (φ <= 0.8o). The region covered includes 86 known pulsars (PSR), 63 known supernova remnants (SNR) and nine GeV sources, representing a significant fraction of the known populations. No evidence for emission of TeV gamma radiation was detected, and upper limits range from 0.15 Crab units up to several Crab units, depending on the observation time and zenith angles covered. The ensemble sums over selected SNR and pulsar subsamples and over the GeV-sources yield no indication of emission from these potential sources. The upper limit for the SNR population is 6.7% of the Crab flux and for the pulsar ensemble is 3.6% of the Crab flux.

Induced starburst and nuclear activity: Faith, facts, and theory

NASA Technical Reports Server (NTRS)

Shlosman, Isaac

1990-01-01

The problem of the origin of starburst and nuclear (nonstellar) activity in galaxies is reviewed. A physical understanding of the mechanism(s) that induce both types of activity requires one to address the following issues: (1) what is the source of fuel that powers starbursts and active galactic nuclei; and (2) how is it channeled towards the central regions of host galaxies? As a possible clue, the author examines the role of non-axisymmetric perturbations of galactic disks and analyzes their potential triggers. Global gravitational instabilities in the gas on scales approx. 100 pc appear to be crucial for fueling the active galactic nuclei.

A Drosophila Gustatory Receptor Required for Strychnine Sensation

PubMed Central

Lee, Youngseok; Moon, Seok Jun; Wang, Yijin

2015-01-01

Strychnine is a potent, naturally occurring neurotoxin that effectively protects plants from animal pests by deterring feeding behavior. In insects, such as the fruit fly, Drosophila melanogaster, bitter-tasting aversive compounds are detected primarily through a family of gustatory receptors (GRs), which are expressed in gustatory receptor neurons. We previously described multiple GRs that eliminate the behavioral avoidance to all bitter compounds tested, with the exception of strychnine. Here, we report the identity of a strychnine receptor, referred to as GR47a. We generated a mutation in Gr47a and found that it eliminated strychnine repulsion and strychnine-induced action potentials. GR47a was narrowly tuned, as the responses to other avoidance compounds were unaffected in the mutant animals. This analysis supports an emerging model that Drosophila GRs fall broadly into two specificity classes—one class is comprised of core receptors that are broadly required, whereas the other class, which includes GR47a, consists of narrowly tuned receptors that define chemical specificity. PMID:26187906

THE VARIABLE NEAR-INFRARED COUNTERPART OF THE MICROQUASAR GRS 1758–258

DOE Office of Scientific and Technical Information (OSTI.GOV)

Luque-Escamilla, Pedro L.; Martí, Josep; Muñoz-Arjonilla, Álvaro J., E-mail: peter@ujaen.es, E-mail: jmarti@ujaen.es, E-mail: ajmunoz@ujaen.es

2014-12-10

We present a new study of the microquasar system GRS 1758–258 in the near-infrared domain based on archival observations with the Hubble Space Telescope and the NICMOS camera. In addition to confirming the near-infrared counterpart pointed out by Muñoz-Arjonilla et al., we show that this object displays significant photometric variability. From its average magnitudes, we also find that GRS 1758–258 fits well within the correlation between the optical/near-infrared and X-ray luminosity known to exist for low-mass, black-hole candidate X-ray binaries in a hard state. Moreover, the spectral energy distribution built using all radio, near-infrared, and X-ray data available closest inmore » time to the NICMOS observations can be reasonably interpreted in terms of a self-absorbed radio jet and an irradiated accretion disk model around a stellar-mass black hole. All these facts match the expected behavior of a compact binary system and strengthen our confidence in the counterpart identification.« less

The Fermi Galactic Center GeV excess and implications for dark matter

DOE PAGES

Ackermann, M.; Ajello, M.; Albert, A.; ...

2017-05-04

Here, the region around the Galactic Center (GC) is now well established to be brighter at energies of a few GeV than what is expected from conventional models of diffuse gamma-ray emission and catalogs of known gamma-ray sources. We study the GeV excess using 6.5 yr of data from the Fermi Large Area Telescope. We characterize the uncertainty of the GC excess spectrum and morphology due to uncertainties in cosmic-ray source distributions and propagation, uncertainties in the distribution of interstellar gas in the Milky Way, and uncertainties due to a potential contribution from the Fermi bubbles. We also evaluate uncertaintiesmore » in the excess properties due to resolved point sources of gamma rays. The GC is of particular interest, as it would be expected to have the brightest signal from annihilation of weakly interacting massive dark matter (DM) particles. However, control regions along the Galactic plane, where a DM signal is not expected, show excesses of similar amplitude relative to the local background. Furthermore, based on the magnitude of the systematic uncertainties, we conservatively report upper limits for the annihilation cross-section as a function of particle mass and annihilation channel.« less

The Fermi Galactic Center GeV Excess and Implications for Dark Matter

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ackermann, M.; Buehler, R.; Ajello, M.

2017-05-01

The region around the Galactic Center (GC) is now well established to be brighter at energies of a few GeV than what is expected from conventional models of diffuse gamma-ray emission and catalogs of known gamma-ray sources. We study the GeV excess using 6.5 yr of data from the Fermi Large Area Telescope. We characterize the uncertainty of the GC excess spectrum and morphology due to uncertainties in cosmic-ray source distributions and propagation, uncertainties in the distribution of interstellar gas in the Milky Way, and uncertainties due to a potential contribution from the Fermi bubbles. We also evaluate uncertainties inmore » the excess properties due to resolved point sources of gamma rays. The GC is of particular interest, as it would be expected to have the brightest signal from annihilation of weakly interacting massive dark matter (DM) particles. However, control regions along the Galactic plane, where a DM signal is not expected, show excesses of similar amplitude relative to the local background. Based on the magnitude of the systematic uncertainties, we conservatively report upper limits for the annihilation cross-section as a function of particle mass and annihilation channel.« less

Carbon dioxide receptor genes in cotton bollworm Helicoverpa armigera

NASA Astrophysics Data System (ADS)

Xu, Wei; Anderson, Alisha

2015-04-01

Carbon dioxide (CO2) is important in insect ecology, eliciting a range of behaviours across different species. Interestingly, the numbers of CO2 gustatory receptors (GRs) vary among insect species. In the model organism Drosophila melanogaster, two GRs (DmelGR21a and DmelGR63a) have been shown to detect CO2. In the butterfly, moth, beetle and mosquito species studied so far, three CO2 GR genes have been identified, while in tsetse flies, four CO2 GR genes have been identified. In other species including honeybees, pea aphids, ants, locusts and wasps, no CO2 GR genes have been identified from the genome. These genomic differences may suggest different mechanisms for CO2 detection exist in different insects but, with the exception of Drosophila and mosquitoes, limited attention has been paid to the CO2 GRs in insects. Here, we cloned three putative CO2 GR genes from the cotton bollworm Helicoverpa armigera and performed phylogenetic and expression analysis. All three H. armigera CO2 GRs (HarmGR1, HarmGR2 and HarmGR3) are specifically expressed in labial palps, the CO2-sensing tissue of this moth. HarmGR3 is significantly activated by NaHCO3 when expressed in insect Sf9 cells but HarmGR1 and HarmGR2 are not. This is the first report characterizing the function of lepidopteran CO2 receptors, which contributes to our general understanding of the molecular mechanisms of insect CO2 gustatory receptors.

PETER: A Hardware Simulator for the Test Mass-GRS System of LISA Pathfinder

NASA Astrophysics Data System (ADS)

Marconi, L.; Stanga, R.; Bassan, M.; De Marchi, F.; Pucacco, G.; Visco, M.; Di Fiore, L.; De Rosa, R.; Garufi, F.

2013-01-01

Each LISA PathFinder test mass (TM) will be sensitive to forces along all its 6 Degrees of Freedom (DoFs). Extensive ground testing is required in order to evaluate the influence of cross-talks from the read-out and actuator channels. In the INFN laboratory of Firenze we have developed a facility for a good representation of the free fall conditions of the TM on flight. A hollow replica of a TM hanging from a double torsion pendulum can move inside a Gravitational Reference Sensor (GRS) with quasi free fall condition on two Dofs, in the frequency band (0.1 ÷ 100)mHz. On both DoFs, the target residual accelerations (yet to be achieved) at the low end frequency range are ≤ 3 × 10-13ms-2, limited by the thermal noise of the fibres. At higher frequencies, the sensitivity is limited by the readout noise of the readout, a replica of the flight electronics. After a long commissioning, we are now in operating conditions, and can carry out a series of experiments to better qualify the interaction between TM and GRS. In this paper we will show some significant qualification measurements and a first scientific measurements, i.e. the measurement and compensation of the DC bias in the GRS using two independent channels, as well as a measurement of the residual acceleration of the translational DoF, with the feedback loop closed on the rotational one, and viceversa.

Discovery of a Gas Giant Planet in Microlensing Event Ogle-2014-BLG-1760

NASA Technical Reports Server (NTRS)

Bhattacharya, A.; Bennett, D. P.; Bond, I. A.; Sumi, T.; Udalski, A.; Street, R.; Tsapras, Y.; Abe, F.; Freeman, M.; Fukui, A.

2016-01-01

We present the analysis of the planetary microlensing event OGLE-2014-BLG-1760, which shows a strong light-curve signal due to the presence of a Jupiter mass ratio planet. One unusual feature of this event is that the source star is quite blue, with V-I = 1.48 +/- 0.08. This is marginally consistent with a source star in the Galactic bulge, but it could possibly indicate a young source star on the far side of the disk. Assuming a bulge source, we perform a Bayesian analysis assuming a standard Galactic model, and this indicates that the planetary system resides in or near the Galactic bulge at D(sub L) = 6.9 +/- 1.1 kpc. It also indicates a host-star mass of M(sub *) = 0.51(sup + 0.44/sub -0.28) M(sub theta), a planet mass of m(sub p ) = 0.56(sup +0.34/sub -0.26) M(sub J), and a projected star-planet separation of a(perpendicular) = 1.75(sup +0.33/sub -0.34) au. The lens-source relative proper motion is micro(sub rel) = 6.5 +/- 1.1mas per yr. The lens (and stellar host star) is estimated to be very faint compared to the source star, so it is most likely that it can be detected only when the lens and source stars start to separate. Due to the relatively high relative proper motion, the lens and source will be resolved to about approximately 46 mas in 6-8 yr after the peak magnification. So, by 2020-2022, we can hope to detect the lens star with deep, high-resolution images.

The Bolocam Galactic Plane Survey

NASA Technical Reports Server (NTRS)

Glenn, Jason; Aguirre, James; Bally, John; Battersby, Cara; Bradley, Eric Todd; Cyganowski, Claudia; Dowell, Darren; Drosback, Meredith; Dunham, Miranda K.; Evans, Neal J., II;

A Close Look At The Relationship Between WMAP (ILC) Small-Scale Features And Galactic HI Structure

NASA Astrophysics Data System (ADS)

Verschuur, Gerrit L.

2012-05-01

Galactic HI emission profiles surrounding two pairs of features located where large-scale filaments at very different velocities overlap were decomposed into Gaussian components. Families of components defined by similarity of center velocities and line widths were identified and found to be spatially related. Each of the two pairs of HI peaks straddle a high-frequency continuum source revealed in the WMAP survey data. It is suggested that where filamentary HI features are directly interacting high-frequency continuum radiation is being produced. The previously hypothesized mechanism for producing high-frequency continuum radiation involving free-free emission from electrons in the interstellar medium, in this case created where HI filaments interact to produce fractional ionizations of order 5 to 15%, fit the data very closely. The results confirm that WMAP data on small-scale structures believed to be cosmological in origin are in fact compromised by the presence of intervening galactic sources of interstellar electrons clumped on scales typical of interstellar HI structure.

Photon escape probabilities in a semi-infinite plane-parallel medium. [from electron plasma surrounding galactic X-ray sources

NASA Technical Reports Server (NTRS)

Williams, A. C.; Elsner, R. F.; Weisskopf, M. C.; Darbro, W.

1984-01-01

It is shown in this work how to obtain the probabilities of photons escaping from a cold electron plasma environment after having undergone an arbitrary number of scatterings. This is done by retaining the exact differential cross section for Thomson scattering as opposed to using its polarization and angle averaged form. The results are given in the form of recursion relations. The geometry used is the semi-infinite plane-parallel geometry witlh a photon source located on a plane at an arbitrary optical depth below the surface. Analytical expressions are given for the probabilities which are accurate over a wide range of initial optical depth. These results can be used to model compact X-ray galactic sources which are surrounded by an electron-rich plasma.

Oxygen, Neon, and Iron X-Ray Absorption in the Local Interstellar Medium

NASA Technical Reports Server (NTRS)

Gatuzz, Efrain; Garcia, Javier; Kallman, Timothy R.; Mendoza, Claudio

2016-01-01

We present a detailed study of X-ray absorption in the local interstellar medium by analyzing the X-ray spectra of 24 galactic sources obtained with the Chandra High Energy Transmission Grating Spectrometer and the XMM-Newton Reflection Grating Spectrometer. Methods. By modeling the continuum with a simple broken power-law and by implementing the new ISMabs X-ray absorption model, we have estimated the total H, O, Ne, and Fe column densities towards the observed sources. Results. We have determined the absorbing material distribution as a function of source distance and galactic latitude longitude. Conclusions. Direct estimates of the fractions of neutrally, singly, and doubly ionized species of O, Ne, and Fe reveal the dominance of the cold component, thus indicating an overall low degree of ionization. Our results are expected to be sensitive to the model used to describe the continuum in all sources.

The Galactic Center View with Simbol-X

NASA Astrophysics Data System (ADS)

Raimondi, L.; Malaguti, G.; Angelini, L.; Cappi, M.; Grandi, P.; Palumbo, G. G. C.; Puccetti, S.

2009-05-01

The nature of the hard X-ray emission above 3 keV of the Galactic Centre (GC) is still source of controversy. Recent observations with Chandra are consistent with either a population of discrete sources or with a diffuse non thermal emission or, most likely, a combination of the two. The Simbol-X mission will be equipped with a grazing incident telescope imaging up to ~80 keV, providing an improvement of three orders of magnitude in sensitivity and angular resolution compared with the instruments that have operated so far above 10 keV. This capability will enable to directly disentangle between the discrete source versus the diffuse emission scenarios. This is demonstrated by the Simbol-X simulations of the GC shown here, where the input model includes a list of both diffuse and point sources (both resolved and unresolved) using the input spectrum observed with presently operating X-ray telescopes.

MSX Colors of Radio-Selected HII Regions in the Milky Way

NASA Astrophysics Data System (ADS)

Giveon, U.; Becker, R. H.; Helfand, D. J.; White, R. L.

2004-12-01

Investigation of the color properties of sources in the MSX catalog reveals two populations - a blue population composed of mainly evolved stars, masers and molecular clouds, and a red population composed mainly HII regions, planetary nebulae, and unclassified radio sources. We compare the MSX catalog to 5 GHz VLA maps of the first quadrant of the Galactic plane (350o

Chandra and Swift Observations of Unidentified Fermi-LAT Objects

NASA Astrophysics Data System (ADS)

Donato, Davide; Cheung, T.; Gehrels, N.

2010-03-01

In the last year we targeted some of the unidentified Fermi-LAT objects (UFOs) at high Galactic latitude with Chandra and Swift in order to determine the basic properties (positions, fluxes, hardness ratios) of all X-ray sources within the Fermi-LAT localization circles. These satellites enable us to detect the X-ray conterparts with a flux limit that is at least an order of magnitude lower than achieved in extant RASS data and to further follow-up at other wavelengths, with the ultimate goal to reveal the nature of these enigmatic gamma-ray sources. Here we present the results obtained with 5 Chandra pointings of high Galactic latitude UFOs in the Fermi-LAT 3-months bright source list. The association of detected X-ray sources within the improved 11-months Fermi-LAT localization circles with available optical and radio observations is discussed.

Fermi bubbles as a source of cosmic rays above 1015 eV

NASA Astrophysics Data System (ADS)

Chernyshov, D. O.; Cheng, K. S.; Dogiel, V. A.; Ko, C. M.

2014-11-01

Fermi bubbles are giant gamma-ray structures extended north and south of the Galactic center with characteristic sizes of order of 10 kpc recently discovered by Fermi Large Area Telescope. Good correlation between radio and gamma-ray emission in the region covered by Fermi bubbles implies the presence of high-energy electrons in this region. Since it is relatively difficult for relativistic electrons of this energy to travel all the way from the Galactic sources toward Fermi bubbles one can assume that they accelerated in-situ. The corresponding acceleration mechanism should also affect the distribution of the relativistic protons in the Galaxy. Since protons have much larger lifetimes the effect may even be observed near the Earth. In our model we suggest that Fermi bubbles are created by acceleration of electrons on series of shocks born due to periodic star accretions by supermassive black hole Sgr A*. We propose that hadronic CR within the 'knee' of the observed CR spectrum are produced by Galactic supernova remnants distributed in the Galactic disk. Reacceleration of these particles in the Fermi Bubble produces CRs beyond the knee. This model provides a natural explanation of the observed CR flux, spectral indexes, and matching of spectra at the knee.

Milky Way demographics with the VVV survey. I. The 84-million star colour-magnitude diagram of the Galactic bulge

NASA Astrophysics Data System (ADS)

Saito, R. K.; Minniti, D.; Dias, B.; Hempel, M.; Rejkuba, M.; Alonso-García, J.; Barbuy, B.; Catelan, M.; Emerson, J. P.; Gonzalez, O. A.; Lucas, P. W.; Zoccali, M.

2012-08-01

Context. The Milky Way (MW) bulge is a fundamental Galactic component for understanding the formation and evolution of galaxies, in particular our own. The ESO Public Survey VISTA Variables in the Vía Láctea is a deep near-IR survey mapping the Galactic bulge and southern plane. Particularly for the bulge area, VVV is covering ~315 deg2. Data taken during 2010 and 2011 covered the entire bulge area in the JHKs bands. Aims: We used VVV data for the whole bulge area as a single and homogeneous data set to build for the first time a single colour - magnitude diagram (CMD) for the entire Galactic bulge. Methods: Photometric data in the JHKs bands were combined to produce a single and huge data set containing 173 150 467 sources in the three bands, for the ~315 deg2 covered by VVV in the bulge. Selecting only the data points flagged as stellar, the total number of sources is 84 095 284. Results: We built the largest colour-magnitude diagrams published up to date, containing 173.1+ million sources for all data points, and more than 84.0 million sources accounting for the stellar sources only. The CMD has a complex shape, mostly owing to the complexity of the stellar population and the effects of extinction and reddening towards the Galactic centre. The red clump (RC) giants are seen double in magnitude at b ~ -8° -10°, while in the inner part (b ~ -3°) they appear to be spreading in colour, or even splitting into a secondary peak. Stellar population models show the predominance of main-sequence and giant stars. The analysis of the outermost bulge area reveals a well-defined sequence of late K and M dwarfs, seen at (J - Ks) ~ 0.7-0.9 mag and Ks ≳ 14 mag. Conclusions: The interpretation of the CMD yields important information about the MW bulge, showing the fingerprint of its structure and content. We report a well-defined red dwarf sequence in the outermost bulge, which is important for the planetary transit searches of VVV. The double RC in magnitude seen in the outer bulge is the signature of the X-shaped MW bulge, while the spreading of the RC in colour, and even its splitting into a secondary peak, are caused by reddening effects. The region around the Galactic centre is harder to interpret because it is strongly affected by reddening and extinction. Based on observations taken within the ESO VISTA Public Survey VVV, Programme ID 179.B-2002.The VVV survey data are available through the ESO archive http://www.eso.org/sci/archive.html

First Year Wilkinson Microwave Anisotropy Probe (WMAP) Observations: Foreground Emission

NASA Technical Reports Server (NTRS)

Bennett, C. L.; Hill, R. S.; Hinshaw, G.; Nolta, M. R.; Odegard, N.; Page, L.; Spergel, D. N.; Weiland, J. L.; Wright, E. L.; Halpern, M.

2003-01-01

The WMAP mission has mapped the full sky to determine the geometry, content, and evolution of the universe. Full sky maps are made in five microwave frequency bands to separate the temperature anisotropy of the cosmic microwave background (CMB) from foreground emission, including diffuse Galactic emission and Galactic and extragalactic point sources. We define masks that excise regions of high foreground emission, so CMB analyses can became out with minimal foreground contamination. We also present maps and spectra of the individual emission components, leading to an improved understanding of Galactic astrophysical processes. The effectiveness of template fits to remove foreground emission from the WMAP data is also examined. These efforts result in a CMB map with minimal contamination and a demonstration that the WMAP CMB power spectrum is insensitive to residual foreground emission. We use a Maximum Entropy Method to construct a model of the Galactic emission components. The observed total Galactic emission matches the model to less than 1% and the individual model components are accurate to a few percent. We find that the Milky Way resembles other normal spiral galaxies between 408 MHz and 23 GHz, with a synchrotron spectral index that is flattest (beta(sub s) approx. -2.5) near star-forming regions, especially in the plane, and steepest (beta(sub s) approx. -3) in the halo. This is consistent with a picture of relativistic cosmic ray electron generation in star-forming regions and diffusion and convection within the plane. The significant synchrotron index steepening out of the plane suggests a diffusion process in which the halo electrons are trapped in the Galactic potential long enough to suffer synchrotron and inverse Compton energy losses and hence a spectral steepening. The synchrotron index is steeper in the WMAP bands than in lower frequency radio surveys, with a spectral break near 20 GHz to beta(sub s) less than -3. The modeled thermal dust spectral index is also steep in the WMAP bands, with beta(sub d) approx. = 2.2. Our model is driven to these conclusions by the low level of total foreground contamination at approx. 60 GHz. Microwave and Ha measurements of the ionized gas agree well with one another at about the expected levels. Spinning dust emission is limited to less than 5% of the Ka-band foreground emission. A catalog of 208 point sources is presented. The reliability of the catalog is 98%, i.e., we expect five of the 208 sources to be statistically spurious. The mean spectral index of the point sources is alpha approx. 0(beta approx. -2). Derived source counts suggest a contribution to the anisotropy power from unresolved sources of (15.0 +/- 1.4) x 10(exp -3)micro sq K sr at Q-band and negligible levels at V-band and W-band. The Sunyaev-Zeldovich effect is shown to be a negligible "contamination" to the maps.

Spectroscopic classification of X-ray sources in the Galactic Bulge Survey

NASA Astrophysics Data System (ADS)

Wevers, T.; Torres, M. A. P.; Jonker, P. G.; Nelemans, G.; Heinke, C.; Mata Sánchez, D.; Johnson, C. B.; Gazer, R.; Steeghs, D. T. H.; Maccarone, T. J.; Hynes, R. I.; Casares, J.; Udalski, A.; Wetuski, J.; Britt, C. T.; Kostrzewa-Rutkowska, Z.; Wyrzykowski, Ł.

2017-10-01

We present the classification of 26 optical counterparts to X-ray sources discovered in the Galactic Bulge Survey. We use (time-resolved) photometric and spectroscopic observations to classify the X-ray sources based on their multiwavelength properties. We find a variety of source classes, spanning different phases of stellar/binary evolution. We classify CX21 as a quiescent cataclysmic variable (CV) below the period gap, and CX118 as a high accretion rate (nova-like) CV. CXB12 displays excess UV emission, and could contain a compact object with a giant star companion, making it a candidate symbiotic binary or quiescent low-mass X-ray binary (although other scenarios cannot be ruled out). CXB34 is a magnetic CV (polar) that shows photometric evidence for a change in accretion state. The magnetic classification is based on the detection of X-ray pulsations with a period of 81 ± 2 min. CXB42 is identified as a young stellar object, namely a weak-lined T Tauri star exhibiting (to date unexplained) UX Ori-like photometric variability. The optical spectrum of CXB43 contains two (resolved) unidentified double-peaked emission lines. No known scenario, such as an active galactic nucleus or symbiotic binary, can easily explain its characteristics. We additionally classify 20 objects as likely active stars based on optical spectroscopy, their X-ray to optical flux ratios and photometric variability. In four cases we identify the sources as binary stars.

Galactic cold cores. IV. Cold submillimetre sources: catalogue and statistical analysis

NASA Astrophysics Data System (ADS)

Montillaud, J.; Juvela, M.; Rivera-Ingraham, A.; Malinen, J.; Pelkonen, V.-M.; Ristorcelli, I.; Montier, L.; Marshall, D. J.; Marton, G.; Pagani, L.; Toth, L. V.; Zahorecz, S.; Ysard, N.; McGehee, P.; Paladini, R.; Falgarone, E.; Bernard, J.-P.; Motte, F.; Zavagno, A.; Doi, Y.

2015-12-01

Context. For the project Galactic cold cores, Herschel photometric observations were carried out as a follow-up of cold regions of interstellar clouds previously identified with the Planck satellite. The aim of the project is to derive the physical properties of the population of cold sources and to study its connection to ongoing and future star formation. Aims: We build a catalogue of cold sources within the clouds in 116 fields observed with the Herschel PACS and SPIRE instruments. We wish to determine the general physical characteristics of the cold sources and to examine the correlations with their host cloud properties. Methods: From Herschel data, we computed colour temperature and column density maps of the fields. We estimated the distance to the target clouds and provide both uncertainties and reliability flags for the distances. The getsources multiwavelength source extraction algorithm was employed to build a catalogue of several thousand cold sources. Mid-infrared data were used, along with colour and position criteria, to separate starless and protostellar sources. We also propose another classification method based on submillimetre temperature profiles. We analysed the statistical distributions of the physical properties of the source samples. Results: We provide a catalogue of ~4000 cold sources within or near star forming clouds, most of which are located either in nearby molecular complexes (≲1 kpc) or in star forming regions of the nearby galactic arms (~2 kpc). About 70% of the sources have a size compatible with an individual core, and 35% of those sources are likely to be gravitationally bound. Significant statistical differences in physical properties are found between starless and protostellar sources, in column density versus dust temperature, mass versus size, and mass versus dust temperature diagrams. The core mass functions are very similar to those previously reported for other regions. On statistical grounds we find that gravitationally bound sources have higher background column densities (median Nbg(H2) ~ 5 × 1021 cm-2) than unbound sources (median Nbg(H2) ~ 3 × 1021 cm-2). These values of Nbg(H2) are higher for higher dust temperatures of the external layers of the parent cloud. However, only in a few cases do we find clear Nbg(H2) thresholds for the presence of cores. The dust temperatures of cloud external layers show clear variations with galactic location, as may the source temperatures. Conclusions: Our data support a more complex view of star formation than in the simple idea of a column density threshold. They show a clear influence of the surrounding UV-visible radiation on how cores distribute in their host clouds with possible variations on the Galactic scale. Planck (http://www.esa.int/Planck) is a project of the European Space Agency - ESA - with instruments provided by two scientific consortia funded by ESA member states (in particular the lead countries: France and Italy) with contributions from NASA (USA), and telescope reflectors provided in a collaboration between ESA and a scientific consortium led and funded by Denmark.Herschel is an ESA space observatory with science instruments provided by European-led Principal Investigator consortia and with important participation from NASA.Full Table B.1 is only available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (ftp://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/584/A92

DOE Office of Scientific and Technical Information (OSTI.GOV)

Balaji, Bhaskaran; Cholis, Ilias; Fox, Patrick J.

We analyze the gamma-ray sky at energies of 0.5 to 50 GeV using the undecimated wavelet transform on the sphere. Focusing on the innermore » $$60^{\\circ} \\times 60^{\\circ}$$ of the sky, we identify and characterize four separate residuals beyond the expected Milky Way diffuse emission. We detect the \\textit{Fermi} Bubbles, finding compelling evidence that they are diffuse in nature and contain very little small-scale structure. We detect the "cocoon" inside the Southern Bubble, and we also identify its northern counterpart above 2 GeV. The Northern Cocoon lies along the same axis but is $$\\sim 30 \\%$$ dimmer than the southern one. We characterize the Galactic center excess, which we find extends up to $$20^{\\circ}$$ in $|b|$. At latitudes $$|b| \\leq 5^{\\circ}$$ we find evidence for power in small angular scales that could be the result of point-source contributions, but for $$|b| \\geq 5^{\\circ}$$ the Galactic center excess is dominantly diffuse in its nature. Our findings show that either the Galactic center excess and {\\it Fermi} Bubbles connect smoothly or that the Bubbles brighten significantly below $$15^\\circ$$ in latitude. We find that the Galactic center excess appears off-center by a few degrees towards negative $$\\ell$$. Additionally, we find and characterize two emissions along the Galactic disk centered at $$\\ell \\simeq +25^{\\circ}$$ and $$-20^{\\circ}$$. These emissions are significantly more elongated along the Galactic disk than the Galactic center excess.« less

2FHL: The Second Catalog of Hard Fermi-LAT Sources

DOE PAGES

Ackermann, M.; Ajello, M.; Atwood, W. B.; ...

2016-01-14

We present a catalog of sources detected above 50 GeV by the Fermi-Large Area Telescope (LAT) in 80 months of data. The newly delivered Pass 8 event-level analysis allows the detection and characterization of sources in the 50 GeV–2TeV energy range. In this energy band, Fermi - LAT has detected 360 sources, which constitute the second catalog of hard Fermi -LAT sources (2FHL). The improved angular resolution enables the precise localization of point sources (~1.'7 radius at 68 % C. L.) and the detection and characterization of spatially extended sources. We find that 86% of the sources can be associatedmore » with counterparts at other wavelengths, of which the majority (75%) are active galactic nuclei and the rest (11%) are Galactic sources. Only 25% of the 2FHL sources have been previously detected by Cherenkov telescopes, implying that the 2FHL provides a reservoir of candidates to be followed up at very high energies. This work closes the energy gap between the observations performed at GeV energies by Fermi -LAT on orbit and the observations performed at higher energies by Cherenkov telescopes from the ground.« less

2FHL: The Second Catalog of Hard Fermi-LAT Sources

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ackermann, M.; Ajello, M.; Atwood, W. B.

We present a catalog of sources detected above 50 GeV by the Fermi-Large Area Telescope (LAT) in 80 months of data. The newly delivered Pass 8 event-level analysis allows the detection and characterization of sources in the 50 GeV–2TeV energy range. In this energy band, Fermi - LAT has detected 360 sources, which constitute the second catalog of hard Fermi -LAT sources (2FHL). The improved angular resolution enables the precise localization of point sources (~1.'7 radius at 68 % C. L.) and the detection and characterization of spatially extended sources. We find that 86% of the sources can be associatedmore » with counterparts at other wavelengths, of which the majority (75%) are active galactic nuclei and the rest (11%) are Galactic sources. Only 25% of the 2FHL sources have been previously detected by Cherenkov telescopes, implying that the 2FHL provides a reservoir of candidates to be followed up at very high energies. This work closes the energy gap between the observations performed at GeV energies by Fermi -LAT on orbit and the observations performed at higher energies by Cherenkov telescopes from the ground.« less

Two Populations of SiO Masers in the Galactic Bulge

NASA Astrophysics Data System (ADS)

Trapp, Adam; Rich, Robert Michael; Morris, Mark; Pihlstrom, Ylva; Sjouwerman, Lorant; Claussen, Mark J.; Stroh, Michael

2017-01-01

We present a summary of the kinematics of stellar SiO masers observed in the direction of the galactic bulge with ALMA (885 sources), and the JVLA (2,479 sources). These objects are selected by color from the MSX point source catalog, which has given an SiO detection rate of ~70%. The presented sample, along with the ~24,000 sources still being observed and reduced, enable radial velocity measurements even in regions with extreme optical extinction. These maser stars are compared to the known bulge surveys: APOGEE (~25,000 sources), BRAVA (~8000 sources), and GIBS (~6,400 sources). We have found that BAaDE stars in the direction of the bulge exist in two subpopulations: (1) A kinematically hot population exhibiting cylindrical rotation consistent with the other bulge surveys, and (2) a kinematically cold population more consistent with a disk population. In the ALMA data, we find evidence for a -200 km/s feature at (l,b) = (-9,0), possibly the symmetric complement to a previously proposed +200 km/s feature (Nidever 2012), that we do not confirm with our data.

Near-infrared counterparts to the Galactic Bulge Survey X-ray source population

NASA Astrophysics Data System (ADS)

Greiss, S.; Steeghs, D.; Jonker, P. G.; Torres, M. A. P.; Maccarone, T. J.; Hynes, R. I.; Britt, C. T.; Nelemans, G.; Gänsicke, B. T.

2014-03-01

We report on the near-infrared matches, drawn from three surveys, to the 1640 unique X-ray sources detected by Chandra in the Galactic Bulge Survey (GBS). This survey targets faint X-ray sources in the bulge, with a particular focus on accreting compact objects. We present all viable counterpart candidates and associate a false alarm probability (FAP) to each near-infrared match in order to identify the most likely counterparts. The FAP takes into account a statistical study involving a chance alignment test, as well as considering the positional accuracy of the individual X-ray sources. We find that although the star density in the bulge is very high, ˜90 per cent of our sources have an FAP <10 per cent, indicating that for most X-ray sources, viable near-infrared counterparts candidates can be identified. In addition to the FAP, we provide positional and photometric information for candidate counterparts to ˜95 per cent of the GBS X-ray sources. This information in combination with optical photometry, spectroscopy and variability constraints will be crucial to characterize and classify secure counterparts.

Expectations for high energy diffuse galactic neutrinos for different cosmic ray distributions

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pagliaroli, Giulia; Evoli, Carmelo; Villante, Francesco Lorenzo, E-mail: giulia.pagliaroli@gssi.infn.it, E-mail: carmelo.evoli@gssi.infn.it, E-mail: francesco.villante@lngs.infn.it

2016-11-01

The interaction of cosmic rays with the gas contained in our Galaxy is a guaranteed source of diffuse high energy neutrinos. We provide expectations for this component by considering different assumptions for the cosmic ray distribution in the Galaxy which are intended to cover the large uncertainty in cosmic ray propagation models. We calculate the angular dependence of the diffuse galactic neutrino flux and the corresponding rate of High Energy Starting Events in IceCube by including the effect of detector angular resolution. Moreover we discuss the possibility to discriminate the galactic component from an isotropic astrophysical flux. We show thatmore » a statistically significant excess of events from the galactic plane in present IceCube data would disfavour models in which the cosmic ray density is uniform , thus bringing relevant information on the cosmic ray radial distribution.« less