Robot friendly probe and socket assembly

NASA Technical Reports Server (NTRS)

Nyberg, Karen L. (Inventor)

1994-01-01

A probe and socket assembly for serving as a mechanical interface between structures is presented. The assembly comprises a socket having a housing adapted for connection to a first supporting structure and a probe which is readily connectable to a second structure and is designed to be easily grappled and manipulated by a robotic device for insertion and coupling with the socket. Cooperable automatic locking means are provided on the probe shaft and socket housing for automatically locking the probe in the socket when the probe is inserted a predetermined distance. A second cooperable locking means on the probe shaft and housing are adapted for actuation after the probe has been inserted the predetermined distance. Actuation means mounted on the probe and responsive to the grip of the probe handle by a gripping device, such as a robot for conditioning the probe for insertion and are also responsive to release of the grip of the probe handle to actuate the second locking means to provide a hard lock of the probe in the socket.

Development and characterization of a compact hand-held gamma probe system, SURGEOGUIDE, based on NEMA NU3-2004 standards

NASA Astrophysics Data System (ADS)

Kaviani, S.; Zeraatkar, N.; Sajedi, S.; Gorjizadeh, N.; Farahani, M. H.; Ghafarian, P.; El Fakhri, G.; Sabet, H.; Ay, M. R.

2016-12-01

Using an intra-operative gamma probe after periareolar or peritumoral injection of a radiotracer during surgery helps the surgeon to identify the sentinel, or first, nodal site of regional metastasis in clinically node-negative patients. The pathological analysis of this node can have an important influence on the treatment staging in various cancers. This paper reports the design and performance evaluation of a gamma probe recently developed in our department. The detector unit of this system consists of an 8 mm diameter and 10 mm thickness monolithic CsI(Tl) scintillator optically, coupled to a Silicon Photomultiplier (SiPM) with an active area of 6×6 mm2, and a single-hole collimator. The unit is shielded using tungsten. The system can operate in three different modes for Tc-99m, I-131, or F-18 isotopes. The following measurements were carried out to evaluate the performance of the probe: sensitivity in air and scatter medium, spatial resolution in scatter medium, angular resolution in scatter medium, and side and back shielding effectiveness. All experiments have been performed based on the NEMA NU3-2004 standard set up. The measured system sensitivities in air and scatter medium (water) are 1700 cps/MBq and 1770 cps/MBq, respectively, both measured at 3 cm from the collimator. The spatial resolution in the scatter medium is about 45 mm at 3 cm distance from the collimator. Also, the angular resolution of the probe is 74o FWHM. Finally, a shielding effectiveness of 99.5% is measured. The results show that the probe can potentially be used for sentinel lymph node localization during the surgery.

Modeled Martian subsurface elemental composition measurements with the Probing In situ with Neutron and Gamma ray instrument: Gamma and Neutron Measurements on Mars

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nowicki, Suzanne F.; Evans, Larry G.; Starr, Richard D.

Here, the Probing In situ with Neutrons and Gamma rays (PING) instrument is an innovative application of active neutron-induced gamma-ray technology. The objective of PING is to measure the elemental composition of the Martian regolith. As part 2 of a two-part submission, this manuscript presents PING's sensitivities as a function of the Martian regolith depth and PING's uncertainties in the measurements as a function of observation time in passive and active mode. Part 1 of our submission models the associated regolith types. The modeled sensitivities show that in PING's active mode, where both a Pulsed Neutron Generator (PNG) and amore » Gamma-Ray Spectrometer (GRS) are used, PING can interrogate the material below the rover to about 20 cm due to the penetrating nature of the high-energy neutrons and the resulting secondary gamma rays observed with the GRS. PING is capable of identifying most major and minor rock-forming elements, including H, O, Na, Mn, Mg, Al, Si, P, S, Cl, Cr, K, Ca, Ti, Fe and Th. The modeled uncertainties show that PING's use of a PNG reduces the required observation times by an order of magnitude over a passive operating mode where the PNG is turned off. While the active mode allows for more complete elemental inventories with higher sensitivity, the gamma-ray signatures of some elements are strong enough to detect in passive mode. We show that PING can detect changes in key marker elements and make thermal neutron measurements in about 1 minute that are sensitive to H and Cl.« less

Modeled Martian subsurface elemental composition measurements with the Probing In situ with Neutron and Gamma ray instrument: Gamma and Neutron Measurements on Mars

DOE PAGES

Nowicki, Suzanne F.; Evans, Larry G.; Starr, Richard D.; ...

2017-02-01

Here, the Probing In situ with Neutrons and Gamma rays (PING) instrument is an innovative application of active neutron-induced gamma-ray technology. The objective of PING is to measure the elemental composition of the Martian regolith. As part 2 of a two-part submission, this manuscript presents PING's sensitivities as a function of the Martian regolith depth and PING's uncertainties in the measurements as a function of observation time in passive and active mode. Part 1 of our submission models the associated regolith types. The modeled sensitivities show that in PING's active mode, where both a Pulsed Neutron Generator (PNG) and amore » Gamma-Ray Spectrometer (GRS) are used, PING can interrogate the material below the rover to about 20 cm due to the penetrating nature of the high-energy neutrons and the resulting secondary gamma rays observed with the GRS. PING is capable of identifying most major and minor rock-forming elements, including H, O, Na, Mn, Mg, Al, Si, P, S, Cl, Cr, K, Ca, Ti, Fe and Th. The modeled uncertainties show that PING's use of a PNG reduces the required observation times by an order of magnitude over a passive operating mode where the PNG is turned off. While the active mode allows for more complete elemental inventories with higher sensitivity, the gamma-ray signatures of some elements are strong enough to detect in passive mode. We show that PING can detect changes in key marker elements and make thermal neutron measurements in about 1 minute that are sensitive to H and Cl.« less

Gamma rays as probe of fission and quasi-fission dynamics in the reaction 32S + 197Au near the Coulomb barrier

NASA Astrophysics Data System (ADS)

Pulcini, A.; Vardaci, E.; Kozulin, E.; Ashaduzzaman, M.; Borcea, C.; Bracco, A.; Brambilla, S.; Calinescu, S.; Camera, F.; Ciemala, M.; de Canditiis, B.; Dorvaux, O.; Harca, I. M.; Itkis, I.; Kirakosyan, V. V.; Knyazheva, G.; Kozulina, N.; Kolesov, I. V.; La Rana, G.; Maj, A.; Matea, I.; Novikov, K.; Petrone, C.; Quero, D.; Rath, P.; Saveleva, E.; Schmitt, C.; Sposito, G.; Stezowski, O.; Trzaska, W. H.; Wilson, J.

2018-05-01

Compound nucleus fission and quasi-fission are both binary decay channels whose common properties make the experimental separation between them difficult. A way to achieve this separation could be to probe the angular momentum of the binary fragments. This can be done detecting gamma rays in coincidence with the two fragments. As a case study, the reaction 32S + 197Au near the Coulomb barrier has been performed at the Tandem ALTO facility at IPN ORSAY. ORGAM and PARIS, two different gamma detectors arrays, are coupled with the CORSET detector, a two-arm time-of-flight spectrometer. TOF-TOF data were analyzed to reconstruct the mass-energy distribution of the primary fragments coupled with gamma multiplicity and spectroscopic analysis. Preliminary results of will be shown.

Modeled Martian subsurface elemental composition measurements with the Probing In situ with Neutron and Gamma ray instrument

NASA Astrophysics Data System (ADS)

Nowicki, Suzanne F.; Evans, Larry G.; Starr, Richard D.; Schweitzer, Jeffrey S.; Karunatillake, Suniti; McClanahan, Timothy P.; Moersch, Jeffrey E.; Parsons, Ann M.; Tate, Christopher G.

2017-02-01

The Probing In situ with Neutron and Gamma ray (PING) instrument is an innovative application of active neutron-induced gamma ray technology. The objective of PING is to measure the elemental composition of the Martian regolith. This manuscript presents PING's sensitivities as a function of the Martian regolith depth and PING's uncertainties in the measurements as a function of observation time in passive and active mode. The modeled sensitivities show that in PING's active mode, where both a pulsed neutron generator (PNG) and a gamma ray spectrometer (GRS) are used, PING can interrogate the material below the rover to about 20 cm due to the penetrating nature of the high-energy neutrons and the resulting secondary gamma rays observed with the GRS. PING is capable of identifying most major and minor rock-forming elements, including H, O, Na, Mn, Mg, Al, Si, P, S, Cl, Cr, K, Ca, Ti, Fe, and Th. The modeled uncertainties show that PING's use of a PNG reduces the required observation times by an order of magnitude over a passive operating mode where the PNG is turned off. While the active mode allows for more complete elemental inventories with higher sensitivity, the gamma ray signatures of some elements are strong enough to detect in passive mode. We show that PING can detect changes in key marker elements and make thermal neutron measurements in about 1 min that are sensitive to H and Cl.

The Probing In-Situ With Neutron and Gamma Rays (PING) Instrument for Planetary Composition Measurements

NASA Technical Reports Server (NTRS)

Parsons, A.; Bodnarik, J.; Evans, L.; McClanahan, T.; Namkung, M.; Nowicki, S.; Schweitzer, J.; Starr, R.

2012-01-01

The Probing In situ with Neutrons and Gamma rays (PING) instrument (formerly named PNG-GRAND) [I] experiment is an innovative application of the active neutron-gamma ray technology successfully used in oil field well logging and mineral exploration on Earth over many decades. The objective of our active neutron-gamma ray technology program at NASA Goddard Space Flight Center (NASA/GSFC) is to bring PING to the point where it can be flown on a variety of surface lander or rover missions to the Moon, Mars, Venus, asteroids, comets and the satellites of the outer planets and measure their bulk surface and subsurface elemental composition without the need to drill into the surface. Gamma-Ray Spectrometers (GRS) have been incorporated into numerous orbital planetary science missions. While orbital measurements can map a planet, they have low spatial and elemental sensitivity due to the low surface gamma ray emission rates reSUlting from using cosmic rays as an excitation source, PING overcomes this limitation in situ by incorporating a powerful neutron excitation source that permits significantly higher elemental sensitivity elemental composition measurements. PING combines a 14 MeV deuterium-tritium Pulsed Neutron Generator (PNG) with a gamma ray spectrometer and two neutron detectors to produce a landed instrument that can determine the elemental composition of a planet down to 30 - 50 cm below the planet's surface, The penetrating nature of .5 - 10 MeV gamma rays and 14 MeV neutrons allows such sub-surface composition measurements to be made without the need to drill into or otherwise disturb the planetary surface, thus greatly simplifying the lander design, We are cun'ently testing a PING prototype at a unique outdoor neutron instrumentation test facility at NASA/GSFC that provides two large (1.8 m x 1.8 m x ,9 m) granite and basalt test formations placed outdoors in an empty field, Since an independent trace elemental analysis has been performed on both these

Semi-automatic 10/20 Identification Method for MRI-Free Probe Placement in Transcranial Brain Mapping Techniques.

PubMed

Xiao, Xiang; Zhu, Hao; Liu, Wei-Jie; Yu, Xiao-Ting; Duan, Lian; Li, Zheng; Zhu, Chao-Zhe

2017-01-01

The International 10/20 system is an important head-surface-based positioning system for transcranial brain mapping techniques, e.g., fNIRS and TMS. As guidance for probe placement, the 10/20 system permits both proper ROI coverage and spatial consistency among multiple subjects and experiments in a MRI-free context. However, the traditional manual approach to the identification of 10/20 landmarks faces problems in reliability and time cost. In this study, we propose a semi-automatic method to address these problems. First, a novel head surface reconstruction algorithm reconstructs head geometry from a set of points uniformly and sparsely sampled on the subject's head. Second, virtual 10/20 landmarks are determined on the reconstructed head surface in computational space. Finally, a visually-guided real-time navigation system guides the experimenter to each of the identified 10/20 landmarks on the physical head of the subject. Compared with the traditional manual approach, our proposed method provides a significant improvement both in reliability and time cost and thus could contribute to improving both the effectiveness and efficiency of 10/20-guided MRI-free probe placement.

Dynamic gamma knife radiosurgery

NASA Astrophysics Data System (ADS)

Luan, Shuang; Swanson, Nathan; Chen, Zhe; Ma, Lijun

2009-03-01

Gamma knife has been the treatment of choice for various brain tumors and functional disorders. Current gamma knife radiosurgery is planned in a 'ball-packing' approach and delivered in a 'step-and-shoot' manner, i.e. it aims to 'pack' the different sized spherical high-dose volumes (called 'shots') into a tumor volume. We have developed a dynamic scheme for gamma knife radiosurgery based on the concept of 'dose-painting' to take advantage of the new robotic patient positioning system on the latest Gamma Knife C™ and Perfexion™ units. In our scheme, the spherical high dose volume created by the gamma knife unit will be viewed as a 3D spherical 'paintbrush', and treatment planning reduces to finding the best route of this 'paintbrush' to 'paint' a 3D tumor volume. Under our dose-painting concept, gamma knife radiosurgery becomes dynamic, where the patient moves continuously under the robotic positioning system. We have implemented a fully automatic dynamic gamma knife radiosurgery treatment planning system, where the inverse planning problem is solved as a traveling salesman problem combined with constrained least-square optimizations. We have also carried out experimental studies of dynamic gamma knife radiosurgery and showed the following. (1) Dynamic gamma knife radiosurgery is ideally suited for fully automatic inverse planning, where high quality radiosurgery plans can be obtained in minutes of computation. (2) Dynamic radiosurgery plans are more conformal than step-and-shoot plans and can maintain a steep dose gradient (around 13% per mm) between the target tumor volume and the surrounding critical structures. (3) It is possible to prescribe multiple isodose lines with dynamic gamma knife radiosurgery, so that the treatment can cover the periphery of the target volume while escalating the dose for high tumor burden regions. (4) With dynamic gamma knife radiosurgery, one can obtain a family of plans representing a tradeoff between the delivery time and the

GAMMA-RAY AND HARD X-RAY EMISSION FROM PULSAR-AIDED SUPERNOVAE AS A PROBE OF PARTICLE ACCELERATION IN EMBRYONIC PULSAR WIND NEBULAE

DOE Office of Scientific and Technical Information (OSTI.GOV)

Murase, Kohta; Kashiyama, Kazumi; Kiuchi, Kenta

2015-05-20

It has been suggested that some classes of luminous supernovae (SNe) and gamma-ray bursts (GRBs) are driven by newborn magnetars. Fast-rotating proto-neutron stars have also been of interest as potential sources of gravitational waves (GWs). We show that for a range of rotation periods and magnetic fields, hard X-rays and GeV gamma rays provide us with a promising probe of pulsar-aided SNe. It is observationally known that young pulsar wind nebulae (PWNe) in the Milky Way are very efficient lepton accelerators. We argue that, if embryonic PWNe satisfy similar conditions at early stages of SNe (in ∼1–10 months after themore » explosion), external inverse-Compton emission via upscatterings of SN photons is naturally expected in the GeV range as well as broadband synchrotron emission. To fully take into account the Klein–Nishina effect and two-photon annihilation process that are important at early times, we perform detailed calculations including electromagnetic cascades. Our results suggest that hard X-ray telescopes such as NuSTAR can observe such early PWN emission by follow-up observations in months to years. GeV gamma-rays may also be detected by Fermi for nearby SNe, which serve as counterparts of these GW sources. Detecting the signals will give us an interesting probe of particle acceleration at early times of PWNe, as well as clues to driving mechanisms of luminous SNe and GRBs. Since the Bethe–Heitler cross section is lower than the Thomson cross section, gamma rays would allow us to study subphotospheric dissipation. We encourage searches for high-energy emission from nearby SNe, especially SNe Ibc including super-luminous objects.« less

Intraoperative detection of 18F-FDG-avid tissue sites using the increased probe counting efficiency of the K-alpha probe design and variance-based statistical analysis with the three-sigma criteria

PubMed Central

2013-01-01

Background Intraoperative detection of 18F-FDG-avid tissue sites during 18F-FDG-directed surgery can be very challenging when utilizing gamma detection probes that rely on a fixed target-to-background (T/B) ratio (ratiometric threshold) for determination of probe positivity. The purpose of our study was to evaluate the counting efficiency and the success rate of in situ intraoperative detection of 18F-FDG-avid tissue sites (using the three-sigma statistical threshold criteria method and the ratiometric threshold criteria method) for three different gamma detection probe systems. Methods Of 58 patients undergoing 18F-FDG-directed surgery for known or suspected malignancy using gamma detection probes, we identified nine 18F-FDG-avid tissue sites (from amongst seven patients) that were seen on same-day preoperative diagnostic PET/CT imaging, and for which each 18F-FDG-avid tissue site underwent attempted in situ intraoperative detection concurrently using three gamma detection probe systems (K-alpha probe, and two commercially-available PET-probe systems), and then were subsequently surgical excised. Results The mean relative probe counting efficiency ratio was 6.9 (± 4.4, range 2.2–15.4) for the K-alpha probe, as compared to 1.5 (± 0.3, range 1.0–2.1) and 1.0 (± 0, range 1.0–1.0), respectively, for two commercially-available PET-probe systems (P < 0.001). Successful in situ intraoperative detection of 18F-FDG-avid tissue sites was more frequently accomplished with each of the three gamma detection probes tested by using the three-sigma statistical threshold criteria method than by using the ratiometric threshold criteria method, specifically with the three-sigma statistical threshold criteria method being significantly better than the ratiometric threshold criteria method for determining probe positivity for the K-alpha probe (P = 0.05). Conclusions Our results suggest that the improved probe counting efficiency of the K-alpha probe design used in

The Complimentary Role of Methoxy-Isobutyl-Isonitrile and Hand-Held Gamma Probe in Adamantinoma

PubMed Central

Maharaj, Masha; Korowlay, Nisaar; Ellmann, Prof

2016-01-01

Adamantinoma is a rare locally aggressive osteolytic tumor that is found 90% of the time in the diaphysis of the tibia with the remaining lesions found in the fibula and long tubular bones. A case of adamantinoma of the tibia is presented. The added value of nuclear medicine investigations in the workup of this patient is described. A three-phase whole body 99mTc-methylene diphosphonate bone and a whole body 99mTc-methoxy-isobutyl-isonitrile scans were complimentary in the demarcation of viable bone tumor and the assessment of the remainder of the bone and soft tissue to exclude other sites. Intra-operative assistance with a hand-held gamma probe, guided the biopsy of the most metabolically active tumor tissue. Histology revealed a biphasic tumor composed of epithelial and fibrous components, in keeping with an adamantinoma. PMID:26912979

An Ultrasonographic Periodontal Probe

NASA Astrophysics Data System (ADS)

Bertoncini, C. A.; Hinders, M. K.

2010-02-01

Periodontal disease, commonly known as gum disease, affects millions of people. The current method of detecting periodontal pocket depth is painful, invasive, and inaccurate. As an alternative to manual probing, an ultrasonographic periodontal probe is being developed to use ultrasound echo waveforms to measure periodontal pocket depth, which is the main measure of periodontal disease. Wavelet transforms and pattern classification techniques are implemented in artificial intelligence routines that can automatically detect pocket depth. The main pattern classification technique used here, called a binary classification algorithm, compares test objects with only two possible pocket depth measurements at a time and relies on dimensionality reduction for the final determination. This method correctly identifies up to 90% of the ultrasonographic probe measurements within the manual probe's tolerance.

Development of the Probing In-Situ with Neutron and Gamma Rays (PING) Instrument for Planetary Science Applications

NASA Technical Reports Server (NTRS)

Parsons, A.; Bodnarik, J.; Burger, D.; Evans, L.; Floyd, S; Lim, L.; McClanahan, T.; Namkung, M.; Nowicki, S.; Schweitzer, J.;

Intraoperative gamma probe guidance with 99mTc-pertechnetate in the completion thyroidectomy.

PubMed

Aras, Gülseren; Gültekin, Salih Sinan; Küçük, Nuriye Ozlem; Demirer, Seher; Tuğ, Tuğbay

2009-07-01

Intraoperative gamma probe (GP) guidance with (99m)Tc-pertechnetate in the completion total thyroidectomy after a first thyroidectomy was investigated in this prospective study. The study group comprises of fourteen consecutive patients (14 females, age mean 50.2 +/- 12.0 years, age range 29-73 years). All patients underwent a second thyroidectomy due to inadequate (5/14 patients) and complementary (9/14 patients) interventions. Serum-free three iodothyronine, free thyroxin and thyroid stimulating hormone measurements, a neck ultrasonography (USG) and thyroid scintigraphy (TS) were performed in the preoperative and postoperative period. After a 185 MBq (5 mCi) injection of (99m)Tc-pertechnetate, background (BG), left thyroid lobe (LTL), right thyroid lobe (RTL) and pyramidal tyroid lobe (PTL) regions were counted in time before and after resection of thyroid remnants by intraoperative GP. All resection materials were evaluated by histopathologic examination. Preoperative TSH was less than 30 mIU/mL (mean 21 +/- 7) in all patients. Functioning thyroid remnants were shown in 13/14 patients on the preoperative TS and USG, which were diagnosed by USG in one but by TS in other one. We calculated that percentage median (minimum-maximum) values were 220.90% (56.00-411.11%) in LTL, 80.43% (11.54-471.05%) in RTL and 66.60% (-3.33 to 158.33%) in PTL for counts before resection, on the other hand, 15.96% (-20.55 to 47.62%) in LTL, 17.59% (-15.07 to 38.46%) in RTL and 17.59% (-1.96 to 57.14%) in PTL regions for counts after resection. There were statistically significant differences between these values belonging to before and after resection for LTL (p = 0.001), RTL (p = 0.001) and PTL (p = 0.008). Bilateral small foci in a patient and unilateral focus in other patient were observed in postoperative TS. Unilateral focus was detected on the RTL by GP, but not bilateral foci. Postoperative TSH levels increased to 30 mIU/mL (mean 69 +/- 26) at least. There was a statistically

A celestial gamma-ray foreground due to the albedo of small solar system bodies and a remote probe of the interstellar cosmic ray spectrum

DOE Office of Scientific and Technical Information (OSTI.GOV)

Moskalenko, Igor V.; Porter, Troy A.; Digel, Seth W.

2007-12-17

We calculate the {gamma}-ray albedo flux from cosmic-ray (CR) interactions with the solid rock and ice in Main Belt asteroids and Kuiper Belt objects (KBOs) using the Moon as a template. We show that the {gamma}-ray albedo for the Main Belt and Kuiper Belt strongly depends on the small-body mass spectrum of each system and may be detectable by the forthcoming Gamma Ray Large Area Space Telescope (GLAST). The orbits of the Main Belt asteroids and KBOs are distributed near the ecliptic, which passes through the Galactic center and high Galactic latitudes. If detected, the {gamma}-ray emission by the Mainmore » Belt and Kuiper Belt has to be taken into account when analyzing weak {gamma}-ray sources close to the ecliptic, especially near the Galactic center and for signals at high Galactic latitudes, such as the extragalactic {gamma}-ray emission. Additionally, it can be used to probe the spectrum of CR nuclei at close-to-interstellar conditions, and the mass spectrum of small bodies in the Main Belt and Kuiper Belt. The asteroid albedo spectrum also exhibits a 511 keV line due to secondary positrons annihilating in the rock. This may be an important and previously unrecognized celestial foreground for the INTErnational Gamma-Ray Astrophysics Laboratory (INTEGRAL) observations of the Galactic 511 keV line emission including the direction of the Galactic center.« less

TEMPORAL EVOLUTION OF SUB-NANOMETER COMPOSITIONAL PROFILES ACROSS THE GAMMA/GAMMA' INTERFACE IN A MODEL Ni-Al-Cr SUPERALLOY

NASA Technical Reports Server (NTRS)

Sudbrack, Chantal K.; Noebe, Ronald D.; Seidman, David N.

2005-01-01

Early-stage phase separation in a Ni-5.2 Al-14.2 Cr at.% superalloy, isothermally decomposing at 873 K, is investigated with atom-probe tomography. Sub-nanometer scale compositional profiles across the gamma/gamma'(L12) interfaces demonstrate that both the gamma-matrix and the gamma'-precipitate compositions evolve with time. Observed chemical gradients of Al depletion and Cr enrichment adjacent to the gamma'-precipitates are transient, consistent with well-established model predictions for diffusion-limited growth, and mark the first detailed observation of this phenomenon. Furthermore, it is shown that Cr atoms are kinetically trapped in the growing precipitates.

A fully automatic approach for multimodal PET and MR image segmentation in gamma knife treatment planning.

PubMed

Rundo, Leonardo; Stefano, Alessandro; Militello, Carmelo; Russo, Giorgio; Sabini, Maria Gabriella; D'Arrigo, Corrado; Marletta, Francesco; Ippolito, Massimo; Mauri, Giancarlo; Vitabile, Salvatore; Gilardi, Maria Carla

2017-06-01

Nowadays, clinical practice in Gamma Knife treatments is generally based on MRI anatomical information alone. However, the joint use of MRI and PET images can be useful for considering both anatomical and metabolic information about the lesion to be treated. In this paper we present a co-segmentation method to integrate the segmented Biological Target Volume (BTV), using [ 11 C]-Methionine-PET (MET-PET) images, and the segmented Gross Target Volume (GTV), on the respective co-registered MR images. The resulting volume gives enhanced brain tumor information to be used in stereotactic neuro-radiosurgery treatment planning. GTV often does not match entirely with BTV, which provides metabolic information about brain lesions. For this reason, PET imaging is valuable and it could be used to provide complementary information useful for treatment planning. In this way, BTV can be used to modify GTV, enhancing Clinical Target Volume (CTV) delineation. A novel fully automatic multimodal PET/MRI segmentation method for Leksell Gamma Knife ® treatments is proposed. This approach improves and combines two computer-assisted and operator-independent single modality methods, previously developed and validated, to segment BTV and GTV from PET and MR images, respectively. In addition, the GTV is utilized to combine the superior contrast of PET images with the higher spatial resolution of MRI, obtaining a new BTV, called BTV MRI . A total of 19 brain metastatic tumors, undergone stereotactic neuro-radiosurgery, were retrospectively analyzed. A framework for the evaluation of multimodal PET/MRI segmentation is also presented. Overlap-based and spatial distance-based metrics were considered to quantify similarity concerning PET and MRI segmentation approaches. Statistics was also included to measure correlation among the different segmentation processes. Since it is not possible to define a gold-standard CTV according to both MRI and PET images without treatment response assessment

Accuracy of non-operative identification of the sentinel lymph node using combined gamma and ultrasound scanning.

PubMed

Whelehan, P; Vinnicombe, S J; Brown, D C; McLean, D; Evans, A

2014-08-01

To assess how accurately the sentinel lymph node (SLN) can be identified percutaneously, using gamma probe and ultrasound technology. Women with breast cancer, scheduled for wide local excision or mastectomy with SLN biopsy (SLNB), were included. Peri-areolar intradermal injection of technetium-99 nanocolloid was performed on the morning of surgery and 1-2 ml of blue dye was injected in the peri-areolar region once the patient was anaesthetized. Prior to surgery, a gamma probe was used over the skin to identify any hot spot that could represent a SLN. Ultrasound, guided by the hot spot, was then used to visualize potential SLNs and guide the insertion of a localizing wire. The accuracy in localizing the SLN by preoperative gamma-probe guided ultrasonography was assessed by comparison to SLNB. A SLN was correctly identified and marked using gamma-probe guided ultrasonography in 44 of 59 cases (75%; 95% CI: 63-86%). This study supports the case for investigating percutaneous gamma probe and ultrasound guided interventions in the axilla in women with breast cancer, as a potential alternative to surgical SLNB. Copyright © 2014 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.

A Holding Function for Conflict Probe Appiications

NASA Technical Reports Server (NTRS)

McNally, Dave; Walton, Joe

2004-01-01

Conflict Alerts for aircraft in holding patterns are often missed or in error due to fact that holding trajectories are not modeled in Conflict Alert or Conflict Probe logic. In addition, a controller in one sector may not know when aircraft are holding in a neighboring sector. These factors can lead to an increased potential for loss of separation while aircraft are flying in holding patterns. A holding function for conflict probe applications has been developed and tested with air traffic data from Fort Worth Center. The holding function automatically determines when an aircraft enters a holding pattern, builds a holding region around the pattern and then probes the region for conflict with other traffic. The operational concept of use assumes that air traffic controllers are very busy during periods when aircraft are in holding and therefore don't have time to manually enter information which defines a holding pattern and activates conflict probing. For this reason, it is important the holding function automatically detect aircraft in holding and compute a holding region for conflict analysis. The controller is then alerted if other aircraft are predicted to fly through the holding region at the holding altitude.

Commissioning of a new SeHCAT detector and comparison with an uncollimated gamma camera.

PubMed

Taylor, Jonathan C; Hillel, Philip G; Himsworth, John M

2014-10-01

Measurements of SeHCAT (tauroselcholic [75selenium] acid) retention have been used to diagnose bile acid malabsorption for a number of years. In current UK practice the vast majority of centres calculate uptake using an uncollimated gamma camera. Because of ever-increasing demands on gamma camera time, a new 'probe' detector was designed, assembled and commissioned. To validate the system, nine patients were scanned at day 0 and day 7 with both the new probe detector and an uncollimated gamma camera. Commissioning results were largely in line with expectations. Spatial resolution (full-width 95% of maximum) at 1 m was 36.6 cm, the background count rate was 24.7 cps and sensitivity at 1 m was 720.8 cps/MBq. The patient comparison study showed a mean absolute difference in retention measurements of 0.8% between the probe and uncollimated gamma camera, and SD of ± 1.8%. The study demonstrated that it is possible to create a simple, reproducible SeHCAT measurement system using a commercially available scintillation detector. Retention results from the probe closely agreed with those from the uncollimated gamma camera.

An image registration based ultrasound probe calibration

NASA Astrophysics Data System (ADS)

Li, Xin; Kumar, Dinesh; Sarkar, Saradwata; Narayanan, Ram

2012-02-01

Reconstructed 3D ultrasound of prostate gland finds application in several medical areas such as image guided biopsy, therapy planning and dose delivery. In our application, we use an end-fire probe rotated about its axis to acquire a sequence of rotational slices to reconstruct 3D TRUS (Transrectal Ultrasound) image. The image acquisition system consists of an ultrasound transducer situated on a cradle directly attached to a rotational sensor. However, due to system tolerances, axis of probe does not align exactly with the designed axis of rotation resulting in artifacts in the 3D reconstructed ultrasound volume. We present a rigid registration based automatic probe calibration approach. The method uses a sequence of phantom images, each pair acquired at angular separation of 180 degrees and registers corresponding image pairs to compute the deviation from designed axis. A modified shadow removal algorithm is applied for preprocessing. An attribute vector is constructed from image intensity and a speckle-insensitive information-theoretic feature. We compare registration between the presented method and expert-corrected images in 16 prostate phantom scans. Images were acquired at multiple resolutions, and different misalignment settings from two ultrasound machines. Screenshots from 3D reconstruction are shown before and after misalignment correction. Registration parameters from automatic and manual correction were found to be in good agreement. Average absolute differences of translation and rotation between automatic and manual methods were 0.27 mm and 0.65 degree, respectively. The registration parameters also showed lower variability for automatic registration (pooled standard deviation σtranslation = 0.50 mm, σrotation = 0.52 degree) compared to the manual approach (pooled standard deviation σtranslation = 0.62 mm, σrotation = 0.78 degree).

Probing Pre-galactic Metal Enrichment with High-redshift Gamma-Ray Bursts

NASA Astrophysics Data System (ADS)

Wang, F. Y.; Bromm, Volker; Greif, Thomas H.; Stacy, Athena; Dai, Z. G.; Loeb, Abraham; Cheng, K. S.

2012-11-01

We explore high-redshift gamma-ray bursts (GRBs) as promising tools to probe pre-galactic metal enrichment. We utilize the bright afterglow of a Population III (Pop III) GRB exploding in a primordial dwarf galaxy as a luminous background source, and calculate the strength of metal absorption lines that are imprinted by the first heavy elements in the intergalactic medium (IGM). To derive the GRB absorption line diagnostics, we use an existing highly resolved simulation of the formation of a first galaxy which is characterized by the onset of atomic hydrogen cooling in a halo with virial temperature >~ 104 K. We explore the unusual circumburst environment inside the systems that hosted Pop III stars, modeling the density evolution with the self-similar solution for a champagne flow. For minihalos close to the cooling threshold, the circumburst density is roughly proportional to (1 + z) with values of about a few cm-3. In more massive halos, corresponding to the first galaxies, the density may be larger, n >~ 100 cm-3. The resulting afterglow fluxes are weakly dependent on redshift at a fixed observed time, and may be detectable with the James Webb Space Telescope and Very Large Array in the near-IR and radio wavebands, respectively, out to redshift z >~ 20. We predict that the maximum of the afterglow emission shifts from near-IR to millimeter bands with peak fluxes from mJy to Jy at different observed times. The metal absorption line signature is expected to be detectable in the near future. GRBs are ideal tools for probing the metal enrichment in the early IGM, due to their high luminosities and featureless power-law spectra. The metals in the first galaxies produced by the first supernova (SN) explosions are likely to reside in low-ionization stages (C II, O I, Si II and Fe II). We show that, if the afterglow can be observed sufficiently early, analysis of the metal lines may distinguish whether the first heavy elements were produced in a pair

Probing Pre-Galactic Metal Enrichment with High-Redshift Gamma-Ray Bursts

NASA Technical Reports Server (NTRS)

Wang, F. Y.; Bromm, Volker; Greif, Thomas H.; Stacy, Athena; Dai, Z. G.; Loeb, Abraham; Cheng, K. S.

2012-01-01

We explore high-redshift gamma-ray bursts (GRBs) as promising tools to probe pre-galactic metal enrichment. We utilize the bright afterglow of a Population III (Pop III) GRB exploding in a primordial dwarf galaxy as a luminous background source, and calculate the strength of metal absorption lines that are imprinted by the first heavy elements in the intergalactic medium (IGM). To derive the GRB absorption line diagnostics, we use an existing highly resolved simulation of the formation of a first galaxy which is characterized by the onset of atomic hydrogen cooling in a halo with virial temperature approximately greater than10(exp 4) K.We explore the unusual circumburst environment inside the systems that hosted Pop III stars, modeling the density evolution with the self-similar solution for a champagne flow. For minihalos close to the cooling threshold, the circumburst density is roughly proportional to (1 + z) with values of about a few cm(exp -3). In more massive halos, corresponding to the first galaxies, the density may be larger, n approximately greater than100 cm(exp -3). The resulting afterglow fluxes are weakly dependent on redshift at a fixed observed time, and may be detectable with the James Webb Space Telescope and Very Large Array in the near-IR and radio wavebands, respectively, out to redshift z approximately greater than 20. We predict that the maximum of the afterglow emission shifts from near-IR to millimeter bands with peak fluxes from mJy to Jy at different observed times. The metal absorption line signature is expected to be detectable in the near future. GRBs are ideal tools for probing the metal enrichment in the early IGM, due to their high luminosities and featureless power-law spectra. The metals in the first galaxies produced by the first supernova (SN) explosions are likely to reside in low-ionization stages (C II, O I, Si II and Fe II). We show that, if the afterglow can be observed sufficiently early, analysis of the metal lines may

Looking inside jets: optical polarimetry as a probe of Gamma-Ray Bursts physics

NASA Astrophysics Data System (ADS)

Kopac, D.; Mundell, C.

2015-07-01

It is broadly accepted that gamma-ray bursts (GRBs) are powered by accretion of matter by black holes, formed during massive stellar collapse, which launch ultra-relativistic, collimated outflows or jets. The nature of the progenitor star, the structure of the jet, and thus the underlying mechanisms that drive the explosion and provide collimation, remain some of the key unanswered questions. To approach these problems, and in particular the role of magnetic fields in GRBs, early time-resolved polarimetry is the key, because it is the only direct probe of the magnetic fields structure. Using novel fast RINGO polarimeter developed for use on the 2-m robotic optical Liverpool Telescope, we have made the first measurements of optical linear polarization of the early optical afterglows of GRBs, finding linear percentage polarization as high as 30% and, for the first time, making time-resolved polarization measurements. I will present the past 8 years of RINGO observations, discuss how the results fit into the GRB theoretical picture, and highlight recent data, in particular high-time resolution multi-colour optical photometry performed during the prompt GRB phase, which also provides some limits on polarization.

Low-energy gamma ray inspection of brazed aluminum joints

NASA Technical Reports Server (NTRS)

Brown, J. A.

1967-01-01

Americium 241 serves as a suitable radioisotope /gamma ray source/ and exposure probe for radiographic inspection of brazed aluminum joints in areas of limited accessibility. The powdered isotope is contained in a sealed capsule mounted at the end of a spring-loaded pushrod in the probe assembly.

Multiple-scanning-probe tunneling microscope with nanoscale positional recognition function.

PubMed

Higuchi, Seiji; Kuramochi, Hiromi; Laurent, Olivier; Komatsubara, Takashi; Machida, Shinichi; Aono, Masakazu; Obori, Kenichi; Nakayama, Tomonobu

2010-07-01

Over the past decade, multiple-scanning-probe microscope systems with independently controlled probes have been developed for nanoscale electrical measurements. We developed a quadruple-scanning-probe tunneling microscope (QSPTM) that can determine and control the probe position through scanning-probe imaging. The difficulty of operating multiple probes with submicrometer precision drastically increases with the number of probes. To solve problems such as determining the relative positions of the probes and avoiding of contact between the probes, we adopted sample-scanning methods to obtain four images simultaneously and developed an original control system for QSPTM operation with a function of automatic positional recognition. These improvements make the QSPTM a more practical and useful instrument since four images can now be reliably produced, and consequently the positioning of the four probes becomes easier owing to the reduced chance of accidental contact between the probes.

A Hand-Held, Intra-Operative Positron Imaging Probe for Surgical Applications

NASA Astrophysics Data System (ADS)

Sabet, Hamid; Stack, Brendan C.; Nagarkar, Vivek V.

2015-10-01

We have developed a prototype intra-operative β+ imaging probe to help tumor removal and malignant tissue resection. The probe can be used during surgery to provide clear delineation of malignant tissues. Our probe consists of a hybrid scintillator coupled to a silicon photomultiplier (SiPM) array with associated front-end electronics encapsulated in an ergonomic aluminum housing. Pulse shape discrimination electronics has been implemented and integrated into the downstream data acquisition system. The field of view of the probe is 10 ×10 mm2 realized by a 0.4 mm thick CsI:Tl scintillator coupled to a 1 mm thick LYSO. While CsI:Tl layer acts as β+ sensitive detector, LYSO detects gamma radiation where the gamma response can be subtracted from the total signal to improve SNR and contrast. The thickness of the LYSO scintillator is optimized such that it acts as light diffuser to spread the scintillation light generated in CsI:Tl over multiple SiPM pixels for accurate estimation of the β+ interaction location. The probe shows FWHM spatial resolution in the presence of large background radiation. The probe was used to study rabbits with tongue tumors. The experimental results show that the probe can successfully locate the tongue tumors in its active imaging area.

Automated design of genomic Southern blot probes

PubMed Central

2010-01-01

Background Sothern blotting is a DNA analysis technique that has found widespread application in molecular biology. It has been used for gene discovery and mapping and has diagnostic and forensic applications, including mutation detection in patient samples and DNA fingerprinting in criminal investigations. Southern blotting has been employed as the definitive method for detecting transgene integration, and successful homologous recombination in gene targeting experiments. The technique employs a labeled DNA probe to detect a specific DNA sequence in a complex DNA sample that has been separated by restriction-digest and gel electrophoresis. Critically for the technique to succeed the probe must be unique to the target locus so as not to cross-hybridize to other endogenous DNA within the sample. Investigators routinely employ a manual approach to probe design. A genome browser is used to extract DNA sequence from the locus of interest, which is searched against the target genome using a BLAST-like tool. Ideally a single perfect match is obtained to the target, with little cross-reactivity caused by homologous DNA sequence present in the genome and/or repetitive and low-complexity elements in the candidate probe. This is a labor intensive process often requiring several attempts to find a suitable probe for laboratory testing. Results We have written an informatic pipeline to automatically design genomic Sothern blot probes that specifically attempts to optimize the resultant probe, employing a brute-force strategy of generating many candidate probes of acceptable length in the user-specified design window, searching all against the target genome, then scoring and ranking the candidates by uniqueness and repetitive DNA element content. Using these in silico measures we can automatically design probes that we predict to perform as well, or better, than our previous manual designs, while considerably reducing design time. We went on to experimentally validate a number

The role of automatic control in future interplanetary spaceflight

NASA Technical Reports Server (NTRS)

Scull, J. R.; Moore, J. W.

1976-01-01

The paper reviews the guidance and automatic control techniques used in previous U.S. and Soviet lunar and planetary exploration spacecraft, and examines the objectives and requirements of potential future interplanetary missions from the viewpoint of their further demands on automatic control technology. These missions include the Venus orbital imaging radar mission, the Pioneer Mars penetrator mission, the Mars surface sample return mission, Pioneer Saturn/Uranus/Titan probe missions, the Mariner Jupiter orbiter with daughter satellite, and comet and asteroid missions.

Fermi gamma-ray imaging of a radio galaxy.

PubMed

Abdo, A A; Ackermann, M; Ajello, M; Atwood, W B; Baldini, L; Ballet, J; Barbiellini, G; Bastieri, D; Baughman, B M; Bechtol, K; Bellazzini, R; Berenji, B; Blandford, R D; Bloom, E D; Bonamente, E; Borgland, A W; Bregeon, J; Brez, A; Brigida, M; Bruel, P; Burnett, T H; Buson, S; Caliandro, G A; Cameron, R A; Caraveo, P A; Casandjian, J M; Cavazzuti, E; Cecchi, C; Celik, O; Chekhtman, A; Cheung, C C; Chiang, J; Ciprini, S; Claus, R; Cohen-Tanugi, J; Colafrancesco, S; Cominsky, L R; Conrad, J; Costamante, L; Cutini, S; Davis, D S; Dermer, C D; de Angelis, A; de Palma, F; Digel, S W; do Couto e Silva, E; Drell, P S; Dubois, R; Dumora, D; Farnier, C; Favuzzi, C; Fegan, S J; Finke, J; Focke, W B; Fortin, P; Fukazawa, Y; Funk, S; Fusco, P; Gargano, F; Gasparrini, D; Gehrels, N; Georganopoulos, M; Germani, S; Giebels, B; Giglietto, N; Giordano, F; Giroletti, M; Glanzman, T; Godfrey, G; Grenier, I A; Grove, J E; Guillemot, L; Guiriec, S; Hanabata, Y; Harding, A K; Hayashida, M; Hays, E; Hughes, R E; Jackson, M S; Jóhannesson, G; Johnson, A S; Johnson, T J; Johnson, W N; Kamae, T; Katagiri, H; Kataoka, J; Kawai, N; Kerr, M; Knödlseder, J; Kocian, M L; Kuss, M; Lande, J; Latronico, L; Lemoine-Goumard, M; Longo, F; Loparco, F; Lott, B; Lovellette, M N; Lubrano, P; Madejski, G M; Makeev, A; Mazziotta, M N; McConville, W; McEnery, J E; Meurer, C; Michelson, P F; Mitthumsiri, W; Mizuno, T; Moiseev, A A; Monte, C; Monzani, M E; Morselli, A; Moskalenko, I V; Murgia, S; Nolan, P L; Norris, J P; Nuss, E; Ohsugi, T; Omodei, N; Orlando, E; Ormes, J F; Paneque, D; Parent, D; Pelassa, V; Pepe, M; Pesce-Rollins, M; Piron, F; Porter, T A; Rainò, S; Rando, R; Razzano, M; Razzaque, S; Reimer, A; Reimer, O; Reposeur, T; Ritz, S; Rochester, L S; Rodriguez, A Y; Romani, R W; Roth, M; Ryde, F; Sadrozinski, H F-W; Sambruna, R; Sanchez, D; Sander, A; Saz Parkinson, P M; Scargle, J D; Sgrò, C; Siskind, E J; Smith, D A; Smith, P D; Spandre, G; Spinelli, P; Starck, J-L; Stawarz, Ł; Strickman, M S; Suson, D J; Tajima, H; Takahashi, H; Takahashi, T; Tanaka, T; Thayer, J B; Thayer, J G; Thompson, D J; Tibaldo, L; Torres, D F; Tosti, G; Tramacere, A; Uchiyama, Y; Usher, T L; Vasileiou, V; Vilchez, N; Vitale, V; Waite, A P; Wallace, E; Wang, P; Winer, B L; Wood, K S; Ylinen, T; Ziegler, M; Hardcastle, M J; Kazanas, D

2010-05-07

The Fermi Gamma-ray Space Telescope has detected the gamma-ray glow emanating from the giant radio lobes of the radio galaxy Centaurus A. The resolved gamma-ray image shows the lobes clearly separated from the central active source. In contrast to all other active galaxies detected so far in high-energy gamma-rays, the lobe flux constitutes a considerable portion (greater than one-half) of the total source emission. The gamma-ray emission from the lobes is interpreted as inverse Compton-scattered relic radiation from the cosmic microwave background, with additional contribution at higher energies from the infrared-to-optical extragalactic background light. These measurements provide gamma-ray constraints on the magnetic field and particle energy content in radio galaxy lobes, as well as a promising method to probe the cosmic relic photon fields.

Detecting the Attenuation of Blazar Gamma-ray Emission by Extragalactic Background Light with GLAST

NASA Technical Reports Server (NTRS)

Chen, Andrew; Ritz, Steven

1999-01-01

Gamma rays with energy above 10 GeV interact with optical-UV photons resulting in pair production. Therefore, a large sample of high redshift sources of these gamma rays can be used to probe the extragalactic background starlight (EBL) by examining the redshift dependence of the attenuation of the flux above 10 GeV. GLAST, the next generation high-energy gamma-ray telescope, will for the first time have the unique capability to detect thousands of gamma-ray blazars up to redshifts of at least z = 4, with enough angular resolution to allow identification of a large fraction of their optical counterparts. By combining recent determinations of the gamma-ray blazar luminosity function, recent calculations of the high energy gamma-ray opacity due to EBL absorption, and the expected GLAST instrument performance to produce simulated samples of blazars that GLAST would detect, including their redshifts and fluxes, we demonstrate that these blazars have the potential to be a highly effective probe of the EBL.

Probing the Physics of Burning DT Capsules Using Gamma-ray Diagnostics

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hayes-Sterbenz, Anna Catherine; Hale, Gerald M.; Jungman, Gerard

2015-02-01

The Gamma Reaction History (GRH) diagnostic developed and lead by the Los Alamos National Laboratory GRH Team is used to determine the bang time and burn width of imploded inertial confinement fusion capsules at the National Ignition Facility. The GRH team is conceptualizing and designing a new Gamma-­to-Electron Magnetic Spectrometer (GEMS), that would be capable of an energy resolution ΔE/E~3-­5%. In this whitepaper we examine the physics that could be explored by the combination of these two gamma-ray diagnostics, with an emphasis on the sensitivity needed for measurements. The main areas that we consider are hydrodynamical mixing, ablator areal densitymore » and density profile, and temporal variations of the density of the cold fuel and the ablator during the DT burn of the capsule.« less

Comparative testing of pulse oximeter probes.

PubMed

van Oostrom, Johannes H; Melker, Richard J

2004-05-01

The testing of pulse oximeter probes is generally limited to the integrity of the electrical circuit and does not include the optical properties of the probes. Few pulse oximeter testers evaluate the accuracy of both the monitor and the probe. We designed a study to compare the accuracy of nonproprietary probes (OSS Medical) designed for use with Nellcor, Datex-Ohmeda, and Criticare pulse oximeter monitors with that of their corresponding proprietary probes by using a commercial off-the-shelf pulse oximeter tester (Index). The Index pulse oximeter tester does include testing of the optical properties of the pulse oximeter probes. The pulse oximeter tester was given a controlled input that simulated acute apnea. Desaturation curves were automatically recorded from the pulse oximeter monitors with a data-collection computer. Comparisons between equivalent proprietary and nonproprietary probes were performed. Data were analyzed by using univariate and multivariate general linear model analysis. Five OSS Medical probe models were statistically better than the equivalent proprietary probes. The remainder of the probes were statistically similar. Comparative and simulation studies can have significant advantages over human studies because they are cost-effective, evaluate equipment in a clinically relevant scenario, and pose no risk to patients, but they are limited by the realism of the simulation. We studied the performance of pulse oximeter probes in a simulated environment. Our results show significant differences between some probes that affect the accuracy of measurement.

Modelling Hard Gamma-Ray Emission from Supernova Remnants

NASA Technical Reports Server (NTRS)

Baring, Matthew G.

1999-01-01

The observation by the CANGAROO (Collaboration of Australia and Nippon Gamma Ray Observatory at Outback) experiment of TeV emission from SN 1006, in conjunction with several instances of non-thermal X-ray emission from supernova remnants, has led to inferences of super-TeV electrons in these extended sources. While this is sufficient to propel the theoretical community in their modelling of particle acceleration and associated radiation, the anticipated emergence in the next decade of a number of new experiments probing the TeV and sub-TeV bands provides further substantial motivation for modellers. In particular, the quest for obtaining unambiguous gamma-ray signatures of cosmic ray ion acceleration defines a "Holy Grail" for observers and theorists alike. This review summarizes theoretical developments in the prediction of MeV-TeV gamma-rays from supernova remnants over the last five years, focusing on how global properties of models can impact, and be impacted by, hard gamma-ray observational programs, thereby probing the supernova remnant environment. Properties of central consideration include the maximum energy of accelerated particles, the density of the unshocked interstellar medium, the ambient magnetic field, and the relativistic electron-to-proton ratio. Criteria for determining good candidate remnants for observability in the TeV band are identified.

Measurement of electron density using reactance cutoff probe

DOE Office of Scientific and Technical Information (OSTI.GOV)

You, K. H.; Seo, B. H.; Kim, J. H.

2016-05-15

This paper proposes a new measurement method of electron density using the reactance spectrum of the plasma in the cutoff probe system instead of the transmission spectrum. The highly accurate reactance spectrum of the plasma-cutoff probe system, as expected from previous circuit simulations [Kim et al., Appl. Phys. Lett. 99, 131502 (2011)], was measured using the full two-port error correction and automatic port extension methods of the network analyzer. The electron density can be obtained from the analysis of the measured reactance spectrum, based on circuit modeling. According to the circuit simulation results, the reactance cutoff probe can measure themore » electron density more precisely than the previous cutoff probe at low densities or at higher pressure. The obtained results for the electron density are presented and discussed for a wide range of experimental conditions, and this method is compared with previous methods (a cutoff probe using the transmission spectrum and a single Langmuir probe).« less

A link between prompt optical and prompt gamma-ray emission in gamma-ray bursts.

PubMed

Vestrand, W T; Wozniak, P R; Wren, J A; Fenimore, E E; Sakamoto, T; White, R R; Casperson, D; Davis, H; Evans, S; Galassi, M; McGowan, K E; Schier, J A; Asa, J W; Barthelmy, S D; Cummings, J R; Gehrels, N; Hullinger, D; Krimm, H A; Markwardt, C B; McLean, K; Palmer, D; Parsons, A; Tueller, J

2005-05-12

The prompt optical emission that arrives with the gamma-rays from a cosmic gamma-ray burst (GRB) is a signature of the engine powering the burst, the properties of the ultra-relativistic ejecta of the explosion, and the ejecta's interactions with the surroundings. Until now, only GRB 990123 had been detected at optical wavelengths during the burst phase. Its prompt optical emission was variable and uncorrelated with the prompt gamma-ray emission, suggesting that the optical emission was generated by a reverse shock arising from the ejecta's collision with surrounding material. Here we report prompt optical emission from GRB 041219a. It is variable and correlated with the prompt gamma-rays, indicating a common origin for the optical light and the gamma-rays. Within the context of the standard fireball model of GRBs, we attribute this new optical component to internal shocks driven into the burst ejecta by variations of the inner engine. The correlated optical emission is a direct probe of the jet isolated from the medium. The timing of the uncorrelated optical emission is strongly dependent on the nature of the medium.

Sampling probe for microarray read out using electrospray mass spectrometry

DOEpatents

Van Berkel, Gary J.

2004-10-12

An automated electrospray based sampling system and method for analysis obtains samples from surface array spots having analytes. The system includes at least one probe, the probe including an inlet for flowing at least one eluting solvent to respective ones of a plurality of spots and an outlet for directing the analyte away from the spots. An automatic positioning system is provided for translating the probe relative to the spots to permit sampling of any spot. An electrospray ion source having an input fluidicly connected to the probe receives the analyte and generates ions from the analyte. The ion source provides the generated ions to a structure for analysis to identify the analyte, preferably being a mass spectrometer. The probe can be a surface contact probe, where the probe forms an enclosing seal along the periphery of the array spot surface.

Cognitive Arithmetic: Evidence for the Development of Automaticity.

ERIC Educational Resources Information Center

LeFevre, Jo-Anne; Bisanz, Jeffrey

To determine whether children's knowledge of arithmetic facts becomes increasingly "automatic" with age, 7-year-olds, 11-year-olds, and adults were given a number-matching task for which mental arithmetic should have been irrelevant. Specifically, students were required to verify the presence of a probe number in a previously presented pair (e.g.,…

Investigation of gamma radiation induced changes in local structure of borosilicate glass by TDPAC and EXAFS

NASA Astrophysics Data System (ADS)

Kumar, Ashwani; Nayak, C.; Rajput, P.; Mishra, R. K.; Bhattacharyya, D.; Kaushik, C. P.; Tomar, B. S.

2016-12-01

Gamma radiation induced changes in local structure around the probe atom (Hafnium) were investigated in sodium barium borosilicate (NBS) glass, used for immobilization of high level liquid waste generated from the reprocessing plant at Trombay, Mumbai. The (NBS) glass was doped with 181Hf as a probe for time differential perturbed angular correlation (TDPAC) spectroscopy studies, while for studies using extended X-ray absorption fine structure (EXAFS) spectroscopy, the same was doped with 0.5 and 2 % (mole %) hafnium oxide. The irradiated as well as un-irradiated glass samples were studied by TDPAC and EXAFS techniques to obtain information about the changes (if any) around the probe atom due to gamma irradiation. TDPAC spectra of unirradiated and irradiated glasses were similar and reminescent of amorphous materials, indicating negligible effect of gamma radiation on the microstructure around Hafnium probe atom, though the quaqdrupole interaction frequency ( ω Q) and asymmetry parameter ( η) did show a marginal decrease in the irradiated glass compared to that in the unirradiated glass. EXAFS measurements showed a slight decrease in the Hf-O bond distance upon gamma irradiation of Hf doped NBS glass indicating densification of the glass matrix, while the cordination number around hafnium remains unchanged.

High-z Universe with Gamma Ray Bursts

NASA Technical Reports Server (NTRS)

Kouveliotou, C.

2011-01-01

Gamma-Ray Bursts (GRBs) are the most luminous explosions in space and trace the cosmic star formation history back to the first generations of stars. Their bright afterglows allow us to trace the abundances of heavy elements to large distances, thereby measuring cosmic chemical evolution. To date GRBs have been detected up to distances of z=8.23 and possibly even beyond z9. This makes GRBs a unique and powerful tool to probe the high-z Universe up to the re-ionization era. We discuss the current status of the field, place it in context with other probes, and also discuss new mission concepts that have been planned to utilize GRBs as probes.

Study of medical isotope production facility stack emissions and noble gas isotopic signature using automatic gamma-spectra analysis platform

NASA Astrophysics Data System (ADS)

Zhang, Weihua; Hoffmann, Emmy; Ungar, Kurt; Dolinar, George; Miley, Harry; Mekarski, Pawel; Schrom, Brian; Hoffman, Ian; Lawrie, Ryan; Loosz, Tom

2013-04-01

The nuclear industry emissions of the four CTBT (Comprehensive Nuclear-Test-Ban Treaty) relevant radioxenon isotopes are unavoidably detected by the IMS along with possible treaty violations. Another civil source of radioxenon emissions which contributes to the global background is radiopharmaceutical production companies. To better understand the source terms of these background emissions, a joint project between HC, ANSTO, PNNL and CRL was formed to install real-time detection systems to support 135Xe, 133Xe, 131mXe and 133mXe measurements at the ANSTO and CRL 99Mo production facility stacks as well as the CANDU (CANada Deuterium Uranium) primary coolant monitoring system at CRL. At each site, high resolution gamma spectra were collected every 15 minutes using a HPGe detector to continuously monitor a bypass feed from the stack or CANDU primary coolant system as it passed through a sampling cell. HC also conducted atmospheric monitoring for radioxenon at approximately 200 km distant from CRL. A program was written to transfer each spectrum into a text file format suitable for the automatic gamma-spectra analysis platform and then email the file to a server. Once the email was received by the server, it was automatically analysed with the gamma-spectrum software UniSampo/Shaman to perform radionuclide identification and activity calculation for a large number of gamma-spectra in a short period of time (less than 10 seconds per spectrum). The results of nuclide activity together with other spectrum parameters were saved into the Linssi database. This database contains a large amount of radionuclide information which is a valuable resource for the analysis of radionuclide distribution within the noble gas fission product emissions. The results could be useful to identify the specific mechanisms of the activity release. The isotopic signatures of the various radioxenon species can be determined as a function of release time. Comparison of 133mXe and 133Xe activity

Transient Astrophysics Probe

NASA Astrophysics Data System (ADS)

Camp, Jordan; Transient Astrophysics Probe Team

2018-01-01

The Transient Astrophysics Probe (TAP) is a wide-field multi-wavelength transient mission proposed for flight starting in the late 2020s. The mission instruments include unique “Lobster-eye” imaging soft X-ray optics that allow a ~1600 deg2 FoV; a high sensitivity, 1 deg2 FoV soft X-ray telescope; a 1 deg2 FoV Infrared telescope with bandpass 0.6-3 micron; and a set of 8 NaI gamma-ray detectors. TAP’s most exciting capability will be the observation of tens per year of X-ray and IR counterparts of GWs involving stellar mass black holes and neutron stars detected by LIGO/Virgo/KAGRA/LIGO-India, and possibly several per year X-ray counterparts of GWs from supermassive black holes, detected by LISA and Pulsar Timing Arrays. TAP will also discover hundreds of X-ray transients related to compact objects, including tidal disruption events, supernova shock breakouts, and Gamma-Ray Bursts from the epoch of reionization.

Techniques of biological contamination avoidance by atmospheric probes

NASA Technical Reports Server (NTRS)

Defrees, R. E.

1974-01-01

The likelihood of biologically contaminating a planet by an atmospheric probe has a low probability of occurring if the probe is kept biologically clean during terrestrial operations and if the structure remains in tact until the planets life zone is completely penetrated. High standards of cleanliness, monitoring and estimating for remedial actions must be maintained in a probe program. It is not a foregone conclusion, however, that heat sterilization needs to be employed. The use of several techniques having a good potential for lower probe costs are available and appear adequate to render a probe sterile within acceptable bounds. The techniques considered to be satisfactory for minimizing microbial load include: (1) combined heat (at 95-105 C) and gamma radiation; (2) short term heating at 105 + or - 5 C to inactivate all vegetative microbes; (3) irradiation routinely by ultraviolet light; (4) wiping by a bactericidal agent with or without a penetrant; and (5) cleanliness alone.

Discovery of localized TeV gamma-ray sources and diffuse TeV gamma-ray emission from the galactic plane with Milagro using a new background rejection technique

NASA Astrophysics Data System (ADS)

Abdo, Aws Ahmad

2007-08-01

Very high energy gamma-rays can be used to probe some of the most powerful astrophysical objects in the universe, such as active galactic nuclei, supernova remnants and pulsar-powered nebulae. The diffuse gamma radiation arising from the interaction of cosmic-ray particles with matter and radiation in the Galaxy is one of the few probes available to study the origin of cosmic- rays. Milagro is a water Cherenkov detector that continuously views the entire overhead sky. The large field-of-view combined with the long observation time makes Milagro the most sensitive instrument available for the study of large, low surface brightness sources such as the diffuse gamma radiation arising from interactions of cosmic radiation with interstellar matter. In this thesis I present a new background rejection technique for the Milagro detector through the development of a new gamma hadron separation variable. The Abdo variable, A 4 , coupled with the weighting analysis technique significantly improves the sensitivity of the Milagro detector. This new analysis technique resulted in the first discoveries in Milagro. Four localized sources of TeV gamma-ray emission have been discovered, three of which are in the Cygnus region of the Galaxy and one closer to the Galactic center. In addition to these localized sources, a diffuse emission of TeV gamma-rays has been discovered from the Cygnus region of the Galaxy as well. However, the TeV gamma-ray flux as measured at ~12 TeV from the Cygnus region exceeds that predicted from a conventional model of cosmic-ray production and propagation. This observation indicates the existence of either hard-spectrum cosmic-ray sources and/or other sources of TeV gamma rays in the region. Other TeV gamma-ray source candidates with post-trial statistical significances of > 4s have also been observed in the Galactic plane.

PET Probe-Guided Surgery in Patients with Breast Cancer: Proposal for a Methodological Approach.

PubMed

Orsaria, Paolo; Chiaravalloti, Agostino; Fiorentini, Alessandro; Pistolese, Chiara; Vanni, Gianluca; Granai, Alessandra Vittoria; Varvaras, Dimitrios; Danieli, Roberta; Schillaci, Orazio; Petrella, Giuseppe; Buonomo, Oreste Claudio

2017-01-02

Although it is valuable for detecting distant metastases, identifying recurrence, and evaluating responses to chemotherapy, the role of 18 F-fluorodeoxyglucose positron-emission tomography/computed tomography ( 18 F-FDG PET/CT) in assessing locoregional nodal status for initial staging of breast cancer has not yet been well-defined in clinical practice. In the current report, we describe a new PET probe-based clinical approach, with evaluation of the technical performance of a handheld high-energy gamma probe for intraoperative localization of breast carcinomas, and evaluation of lymph node metastases during radio-guided oncological surgery. Three patients underwent a PET/CT scan immediately prior to surgery following the standard clinical protocol. Intraoperatively, tumors were localized and resected with the assistance of a hand-held gamma probe. PET-guided assessment of the presence or absence of regional nodal spread of malignancy was compared with the reference standard of histopathological examination. In all three cases, perioperative 18 F-FDG PET/CT imaging and intraoperative gamma probe detection verified complete resection of the hypermetabolic lesions and demonstrated no additional suspicious occult disease. This innovative approach demonstrates great promise for providing real-time access to metabolic and morphological tumor information that may lead to an optimal disease-tailored approach. In carefully selected indications, a PET probe can be a useful adjunct in surgical practice, but further trials with a larger number of patients need to be performed to verify these findings. Copyright© 2017, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

3D-printed focused collimator for intra-operative gamma-ray detection

NASA Astrophysics Data System (ADS)

Holdsworth, David W.; Nikolov, Hristo N.; Pollmann, Steven I.

2017-03-01

Recent developments in targeted radiopharmaceutical labels have increased the need for sensitive, real-time gamma detection during cancer surgery and biopsy. Additive manufacturing (3D printing) in metal has now made it possible to design and fabricate complex metal collimators for compact gamma probes. We describe the design and implementation of a 3D-printed focused collimator that allows for real-time detection of gamma radiation from within a small volume of interest, using a single-crystal large-area detector. The collimator was fabricated using laser melting of powdered stainless steel (316L), using a commercial 3D metal printer (AM125, Renishaw plc). The prototype collimator is 20 mm thick, with hexagonal close-packed holes designed to focus to a point 35 mm below the surface of the collimator face. Tests were carried out with a low-activity (<1 μCi) 241 Am source, using a conventional gamma-ray detector probe, incorporating a 2.5 cm diameter, 2.5 cm thick NaI crystal coupled to a photomultiplier. The measured full-width half maximum (FWHM) was less than 5.6 mm, and collimator detection efficiency was 44%. The ability to fabricate fine features in solid metal makes it possible to develop optimized designs for high-efficiency, focused gamma collimators for real-time intraoperative imaging applications.

Physical processes and diagnostics of gamma-ray burst emission

NASA Technical Reports Server (NTRS)

Harding, Alice K.

1992-01-01

With improved data from BATSE and other instruments, it is important to develop a range of diagnostic tools to link gamma-ray burst observations with theory. I will review some of the physical processes which may take place to form the spectrum of gamma-ray burst sources, assuming that the bursts originate on strongly magnetized neutron stars. The important diagnostics that these processes provide to probe the emission region and how they might be used to interpret observed spectra will also be discussed.

Modelling Hard Gamma-Ray Emission from Supernova Remnants

NASA Technical Reports Server (NTRS)

Baring, Matthew

2000-01-01

The observation by the CANGAROO experiment of TeV emission from SN 1006, in conjunction with several instances of non-thermal X-ray emission from supernova remnants, has led to inferences of super-TeV electrons in these extended sources. While this is sufficient to propel the theoretical community in their modelling of particle acceleration and associated radiation, the anticipated emergence in the next decade of a number of new experiments probing the TeV and sub-TeV bands provides further substantial motivation for modellers. In particular, the quest for obtaining unambiguous gamma-ray signatures of cosmic ray ion acceleration defines a "Holy Grail" for observers and theorists alike. This review summarizes theoretical developments in the prediction of MeV-TeV gamma-rays from supernova remnants over the last five years, focusing on how global properties of models can impact, and be impacted by, hard gamma-ray observational programs, thereby probing the supernova remnant environment. Properties of central consideration include the maximum energy of accelerated particles, the density of the unshocked interstellar medium, the ambient magnetic field, and the relativistic electron-to-proton ratio. Criteria for determining good candidate remnants for observability in the TeV band are identified.

PCR Amplicon Prediction from Multiplex Degenerate Primer and Probe Sets

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gardner, S. N.

2013-08-08

Assessing primer specificity and predicting both desired and off-target amplification products is an essential step for robust PCR assay design. Code is described to predict potential polymerase chain reaction (PCR) amplicons in a large sequence database such as NCBI nt from either singleplex or a large multiplexed set of primers, allowing degenerate primer and probe bases, with target mismatch annotates amplicons with gene information automatically downloaded from NCBI, and optionally it can predict whether there are also TaqMan/Luminex probe matches within predicted amplicons.

Two sources of evidence on the non-automaticity of true and false belief ascription.

PubMed

Back, Elisa; Apperly, Ian A

2010-04-01

A recent study by Apperly et al. (2006) found evidence that adults do not automatically infer false beliefs while watching videos that afford such inferences. This method was extended to examine true beliefs, which are sometimes thought to be ascribed by "default" (e.g., Leslie & Thaiss, 1992). Sequences of pictures were presented in which the location of an object and a character's belief about the location of the object often changed. During the picture sequences participants responded to an unpredictable probe picture about where the character believed the object to be located or where the object was located in reality. In Experiment 1 participants were not directly instructed to track the character's beliefs about the object. There was a significant reaction time cost for belief probes compared with matched reality probes, whether the character's belief was true or false. In Experiment 2, participants were asked to track where the character thought the object was located, responses to belief probes were faster than responses to reality probes, suggesting that the difference observed in Experiment 1 was not due to intrinsic differences between the probes, but was more likely to be due to participants inferring beliefs ad hoc in response to the probe. In both Experiments 1 and 2, responses to belief and reality probes were faster in the true belief condition than in the false belief condition. In Experiment 3 this difference was largely eliminated when participants had fewer reasons to make belief inferences spontaneously. These two lines of evidence are neatly explained by the proposition that neither true nor false beliefs are ascribed automatically, but that belief ascription may occur spontaneously in response to task demands. Copyright 2009 Elsevier B.V. All rights reserved.

Large-scale anisotropy in the extragalactic gamma-ray background as a probe for cosmological antimatter

NASA Technical Reports Server (NTRS)

Gao, Yi-Tian; Stecker, Floyd W.; Gleiser, Marcelo; Cline, David B.

1990-01-01

Intrinsic anisotropies in the extragalactic gamma-ray background (EGB), which should be detectable with the forthcoming Gamma Ray Observatory, can be used to examine some of the mechanisms proposed to explain its origin, one of which, the baryon-symmetric big bang (BSBB) model, is investigated here. In this simulation, large domains containing matter and antimatter galaxies produce gamma rays by annihilation at the domain boundaries. This mechanism can produce mountain-chain-shaped angular fluctuations in the EGB flux.

Cryogenic probe station for use in automated microwave and noise figure measurements

NASA Technical Reports Server (NTRS)

Taub, Susan R.; Alterovitz, Samuel A.; Young, Paul G.; Ebihara, Ben T.; Romanofsky, Robert R.

1994-01-01

A cryogenic measurement system capable of performing on-wafer RF testing of semiconductor devices and circuits has been developed. This 'CryoProbe Station' can wafer-probe devices and circuits at cryogenic temperatures, thus eliminating the need for wire bonds. The system operates under vacuum created by a sorption pump. It uses an open cycle cooling system that can be cooled with either liquid nitrogen or liquid helium. Presently, it can reach temperatures, as low as 80 K and 37 K for each of the coolants, respectively. The temperature can be raised using a heater and it is stabilized to within 0.2 K by use of a temperature controller. The CryoProbe Station features a 1 by 2 inch stage that can hold large circuits and calibration standards simultaneously. The system is used with a Hewlett Packard 8510C Automatic Network Analyzer (ANA) to obtain S-parameter data over the frequency range 0.045-26.5 GHz. S-parameter data on HEMT (high electron mobility transistors) devices has been obtained with this station. With the use of DEEMBED software from NIST, detailed transmission line studies have been performed. Although the CryoProbe Station is designed for frequencies up to 26.5 GHz, useful transmission line data has been obtained for frequencies as high as 40 GHz. The CryoProbe station has also been used with the ATN noise figure measurement system to perform automatic, temperature dependent noise figure measurements.

Probing CP violation in $$h\\rightarrow\\gamma\\gamma$$ with converted photons

DOE PAGES

Bishara, Fady; Grossman, Yuval; Harnik, Roni; ...

2014-04-11

We study Higgs diphoton decays, in which both photons undergo nuclear conversion to electron- positron pairs. The kinematic distribution of the two electron-positron pairs may be used to probe the CP violating (CPV) coupling of the Higgs to photons, that may be produced by new physics. Detecting CPV in this manner requires interference between the spin-polarized helicity amplitudes for both conversions. We derive leading order, analytic forms for these amplitudes. In turn, we obtain compact, leading-order expressions for the full process rate. While performing experiments involving photon conversions may be challenging, we use the results of our analysis to constructmore » experimental cuts on certain observables that may enhance sensitivity to CPV. We show that there exist regions of phase space on which sensitivity to CPV is of order unity. As a result, the statistical sensitivity of these cuts are verified numerically, using dedicated Monte-Carlo simulations.« less

Automatic cryogenic liquid level controller is safe for use near combustible substances

NASA Technical Reports Server (NTRS)

Krejsa, M.

1966-01-01

Automatic mechanical liquid level controller that is independent of any external power sources is used with safety in the presence of combustibles. A gas filled capillary tube which leads from a pressurized chamber, is inserted into the cryogenic liquid reservoir and becomes a liquid level sensing element or probe.

Surgical guidance system using hand-held probe with accompanying positron coincidence detector

DOE Office of Scientific and Technical Information (OSTI.GOV)

Majewski, Stanislaw; Weisenberger, Andrew G.

A surgical guidance system offering different levels of imaging capability while maintaining the same hand-held convenient small size of light-weight intra-operative probes. The surgical guidance system includes a second detector, typically an imager, located behind the area of surgical interest to form a coincidence guidance system with the hand-held probe. This approach is focused on the detection of positron emitting biomarkers with gamma rays accompanying positron emissions from the radiolabeled nuclei.

MoonBEAM: Gamma-Ray Burst Detectors on SmallSAT

NASA Technical Reports Server (NTRS)

Hui, C. M.; Briggs, M. S.; Goldstein, A. M.; Jenke, P. A.; Kocevski, D.; Wilson-Hodge, C. A.

2018-01-01

Moon Burst Energetics All-sky Monitor (MoonBEAM) is a CubeSat concept of deploying gamma-ray detectors in cislunar space to improve localization precision for gamma-ray bursts by utilizing the light travel time difference between a spacecraft in Earth and cislunar orbit. MoonBEAM is designed with high TRL components to be flight ready. This instrument would probe the extreme processes in cosmic collision of compact objects and facilitate multi-messenger time-domain astronomy to explore the end of stellar life cycles and black hole formations.

Automatic optimisation of gamma dose rate sensor networks: The DETECT Optimisation Tool

NASA Astrophysics Data System (ADS)

Helle, K. B.; Müller, T. O.; Astrup, P.; Dyve, J. E.

2014-05-01

Fast delivery of comprehensive information on the radiological situation is essential for decision-making in nuclear emergencies. Most national radiological agencies in Europe employ gamma dose rate sensor networks to monitor radioactive pollution of the atmosphere. Sensor locations were often chosen using regular grids or according to administrative constraints. Nowadays, however, the choice can be based on more realistic risk assessment, as it is possible to simulate potential radioactive plumes. To support sensor planning, we developed the DETECT Optimisation Tool (DOT) within the scope of the EU FP 7 project DETECT. It evaluates the gamma dose rates that a proposed set of sensors might measure in an emergency and uses this information to optimise the sensor locations. The gamma dose rates are taken from a comprehensive library of simulations of atmospheric radioactive plumes from 64 source locations. These simulations cover the whole European Union, so the DOT allows evaluation and optimisation of sensor networks for all EU countries, as well as evaluation of fencing sensors around possible sources. Users can choose from seven cost functions to evaluate the capability of a given monitoring network for early detection of radioactive plumes or for the creation of dose maps. The DOT is implemented as a stand-alone easy-to-use JAVA-based application with a graphical user interface and an R backend. Users can run evaluations and optimisations, and display, store and download the results. The DOT runs on a server and can be accessed via common web browsers; it can also be installed locally.

Assisting persons with multiple disabilities to move through simple occupational activities with automatic prompting.

PubMed

Lancioni, Giulio E; Singh, Nirbhay N; O'Reilly, Mark F; Sigafoos, Jeff; Oliva, Doretta; Campodonico, Francesca; Groeneweg, Jop

2008-01-01

The present study assessed the possibility of assisting four persons with multiple disabilities to move through and perform simple occupational activities arranged within a room with the help of automatic prompting. The study involved two multiple probe designs across participants. The first multiple probe concerned the two participants with blindness or minimal vision and deafness, who received air blowing as a prompt. The second multiple probe concerned the two participants with blindness and typical hearing who received a voice calling as a prompt. Initially, all participants had baseline sessions. Then intervention started with the first participant of each dyad. When their performance was consolidated, new baseline and intervention occurred with the second participant of each dyad. Finally, all four participants were exposed to a second intervention phase, in which the number of activities per session doubled (i.e., from 8 to 16). Data showed that all four participants: (a) learned to move across and perform the activities available with the help of automatic prompting and (b) remained highly successful through the second intervention phase when the sessions were extended. Implications of the findings are discussed.

Constraints on the phase gamma and new physics from B --> kpi decays

PubMed

He; Hsueh; Shi

2000-01-03

Recent results from CLEO on B-->Kpi indicate that the phase gamma may be substantially different from that obtained from other fit to the KM matrix elements in the standard model. We show that gamma extracted using B-->Kpi,pipi is sensitive to new physics occurring at loop level. It provides a powerful method to probe new physics in electroweak penguin interactions. Using effects due to anomalous gauge couplings as an example, we show that within the allowed ranges for these couplings information about gamma obtained from B-->Kpi,pipi can be very different from the standard model prediction.

A versatile calibration procedure for portable coded aperture gamma cameras and RGB-D sensors

NASA Astrophysics Data System (ADS)

Paradiso, V.; Crivellaro, A.; Amgarou, K.; de Lanaute, N. Blanc; Fua, P.; Liénard, E.

2018-04-01

The present paper proposes a versatile procedure for the geometrical calibration of coded aperture gamma cameras and RGB-D depth sensors, using only one radioactive point source and a simple experimental set-up. Calibration data is then used for accurately aligning radiation images retrieved by means of the γ-camera with the respective depth images computed with the RGB-D sensor. The system resulting from such a combination is thus able to retrieve, automatically, the distance of radioactive hotspots by means of pixel-wise mapping between gamma and depth images. This procedure is of great interest for a wide number of applications, ranging from precise automatic estimation of the shape and distance of radioactive objects to Augmented Reality systems. Incidentally, the corresponding results validated the choice of a perspective design model for a coded aperture γ-camera.

Measurement of gastric emptying by intragastric gamma scintigraphy.

PubMed

Malbert, C H; Mathis, C; Bobillier, E; Laplace, J P; Horowitz, M

1997-09-01

Gastric emptying is usually measured in animals and humans by dilution/sampling or external scintigraphy. These methods are either time consuming or require expensive equipment. The capacity of a miniature gamma counter positioned in the stomach to measure emptying of liquid and solid meals was evaluated. In eight conscious pigs fitted with gastric and duodenal cannulae, gastric emptying of saline (500 mL), dextrose (20%, 500 mL), porridge (300 g) and scrambled eggs (300 g), all labelled with 3.5 MBq 99mTC, was evaluated. When positioned in the antrum the probe was unable to quantify gastric emptying. In contrast, measurements of the fractional emptying of saline over 4-min periods by the probe positioned in the corpus and quantification of radioactivity in the duodenal effluent correlated closely (r = 0.88, P < 0.05). Gastric emptying (50% emptying time) of saline and both solid meals measured by the probe was not significantly different from quantification of the duodenal effluent volume. No difference was observed also for the dextrose meal but only while gastric acid secretion was suppressed by omeprazole. We conclude that an intragastric gamma counter permits measurement of gastric emptying of homogeneous meals provided meal stimulation of gastric secretion was not extensive. This was possible probably by monitoring emptying from the proximal stomach.

Metal enrichment in the Fermi bubbles as a probe of their origin

NASA Astrophysics Data System (ADS)

Inoue, Yoshiyuki; Nakashima, Shinya; Tahara, Masaya; Kataoka, Jun; Totani, Tomonori; Fujita, Yutaka; Sofue, Yoshiaki

2015-06-01

The Fermi bubbles are gigantic gamma-ray structures in our Galaxy. The physical origin of the bubbles is still under debate. The leading scenarios can be divided into two categories. One is nuclear star-forming activity similar to extragalactic starburst galaxies and the other is past active galactic nucleus (AGN)-like activity of the Galactic center supermassive black hole. In this letter, we propose that metal abundance measurements will provide an important clue to probe their origin. Based on a simple spherically symmetric bubble model, we find that the generated metallicity and abundance patterns of the bubbles' gas strongly depend on assumed star formation or AGN activities. Star formation scenarios predict higher metallicities and abundance ratios of [O/Fe] and [Ne/Fe] than AGN scenarios do because of supernovae ejecta. Furthermore, the resultant abundance depends on the gamma-ray emission process because different mass injection histories are required for the different gamma-ray emission processes due to the acceleration and cooling time scales of non-thermal particles. Future X-ray missions such as ASTRO-H and Athena will give a clue to probe the origin of the bubbles through abundance measurements with their high energy resolution instruments.

Toward of a highly integrated probe for improving wireless network quality

NASA Astrophysics Data System (ADS)

Ding, Fei; Song, Aiguo; Wu, Zhenyang; Pan, Zhiwen; You, Xiaohu

2016-10-01

Quality of service and customer perception is the focus of the telecommunications industry. This paper proposes a low-cost approach to the acquisition of terminal data, collected from LTE networks with the application of a soft probe, based on the Java language. The soft probe includes support for fast call in the form of a referenced library, and can be integrated into various Android-based applications to automatically monitor any exception event in the network. Soft probe-based acquisition of terminal data has the advantages of low cost and can be applied on large scale. Experiment shows that a soft probe can efficiently obtain terminal network data. With this method, the quality of service of LTE networks can be determined from acquired wireless data. This work contributes to efficient network optimization, and the analysis of abnormal network events.

Strategies for automatic planning: A collection of ideas

NASA Technical Reports Server (NTRS)

Collins, Carol; George, Julia; Zamani, Elaine

1989-01-01

The main goal of the Jet Propulsion Laboratory (JPL) is to obtain science return from interplanetary probes. The uplink process is concerned with communicating commands to a spacecraft in order to achieve science objectives. There are two main parts to the development of the command file which is sent to a spacecraft. First, the activity planning process integrates the science requests for utilization of spacecraft time into a feasible sequence. Then the command generation process converts the sequence into a set of commands. The development of a feasible sequence plan is an expensive and labor intensive process requiring many months of effort. In order to save time and manpower in the uplink process, automation of parts of this process is desired. There is an ongoing effort to develop automatic planning systems. This has met with some success, but has also been informative about the nature of this effort. It is now clear that innovative techniques and state-of-the-art technology will be required in order to produce a system which can provide automatic sequence planning. As part of this effort to develop automatic planning systems, a survey of the literature, looking for known techniques which may be applicable to our work was conducted. Descriptions of and references for these methods are given, together with ideas for applying the techniques to automatic planning.

The epidural needle guidance with an intelligent and automatic identification system for epidural anesthesia

NASA Astrophysics Data System (ADS)

Kao, Meng-Chun; Ting, Chien-Kun; Kuo, Wen-Chuan

2018-02-01

Incorrect placement of the needle causes medical complications in the epidural block, such as dural puncture or spinal cord injury. This study proposes a system which combines an optical coherence tomography (OCT) imaging probe with an automatic identification (AI) system to objectively identify the position of the epidural needle tip. The automatic identification system uses three features as image parameters to distinguish the different tissue by three classifiers. Finally, we found that the support vector machine (SVM) classifier has highest accuracy, specificity, and sensitivity, which reached to 95%, 98%, and 92%, respectively.

Gamma-Ray Bursts in the Swift Era

NASA Technical Reports Server (NTRS)

Gehrels, Neil; Ramirez-Ruiz, E.; Fox, D. B.

2010-01-01

With its rapid-response capability and multiwavelength complement of instruments, the Swift satellite has transformed our physical understanding of gamma-ray bursts. Providing high-quality observations of hundreds of bursts, and facilitating a wide range of follow-up observations within seconds of each event, Swift has revealed an unforeseen richness in observed burst properties, shed light on the nature of short-duration bursts, and helped realize the promise of gamma-ray bursts as probes of the processes and environments of star formation out to the earliest cosmic epochs. These advances have opened new perspectives on the nature and properties of burst central engines, interactions with the burst environment from microparsec to gigaparsec scales, and the possibilities for non-photonic signatures. Our understanding of these extreme cosmic sources has thus advanced substantially; yet more than forty years after their discovery, gamma-ray bursts continue to present major challenges on both observational and theoretical fronts.

Autonomous Scanning Probe Microscopy in Situ Tip Conditioning through Machine Learning.

PubMed

Rashidi, Mohammad; Wolkow, Robert A

2018-05-23

Atomic-scale characterization and manipulation with scanning probe microscopy rely upon the use of an atomically sharp probe. Here we present automated methods based on machine learning to automatically detect and recondition the quality of the probe of a scanning tunneling microscope. As a model system, we employ these techniques on the technologically relevant hydrogen-terminated silicon surface, training the network to recognize abnormalities in the appearance of surface dangling bonds. Of the machine learning methods tested, a convolutional neural network yielded the greatest accuracy, achieving a positive identification of degraded tips in 97% of the test cases. By using multiple points of comparison and majority voting, the accuracy of the method is improved beyond 99%.

SU-E-T-50: Automatic Validation of Megavoltage Beams Modeled for Clinical Use in Radiation Therapy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Melchior, M; Salinas Aranda, F; 21st Century Oncology, Ft. Myers, FL

2014-06-01

Purpose: To automatically validate megavoltage beams modeled in XiO™ 4.50 (Elekta, Stockholm, Sweden) and Varian Eclipse™ Treatment Planning Systems (TPS) (Varian Associates, Palo Alto, CA, USA), reducing validation time before beam-on for clinical use. Methods: A software application that can automatically read and analyze DICOM RT Dose and W2CAD files was developed using MatLab integrated development environment.TPS calculated dose distributions, in DICOM RT Dose format, and dose values measured in different Varian Clinac beams, in W2CAD format, were compared. Experimental beam data used were those acquired for beam commissioning, collected on a water phantom with a 2D automatic beam scanningmore » system.Two methods were chosen to evaluate dose distributions fitting: gamma analysis and point tests described in Appendix E of IAEA TECDOC-1583. Depth dose curves and beam profiles were evaluated for both open and wedged beams. Tolerance parameters chosen for gamma analysis are 3% and 3 mm dose and distance, respectively.Absolute dose was measured independently at points proposed in Appendix E of TECDOC-1583 to validate software results. Results: TPS calculated depth dose distributions agree with measured beam data under fixed precision values at all depths analyzed. Measured beam dose profiles match TPS calculated doses with high accuracy in both open and wedged beams. Depth and profile dose distributions fitting analysis show gamma values < 1. Relative errors at points proposed in Appendix E of TECDOC-1583 meet therein recommended tolerances.Independent absolute dose measurements at points proposed in Appendix E of TECDOC-1583 confirm software results. Conclusion: Automatic validation of megavoltage beams modeled for their use in the clinic was accomplished. The software tool developed proved efficient, giving users a convenient and reliable environment to decide whether to accept or not a beam model for clinical use. Validation time before beam-on for

How gravitational-wave observations can shape the gamma-ray burst paradigm

NASA Astrophysics Data System (ADS)

Bartos, I.; Brady, P.; Márka, S.

2013-06-01

By reaching through shrouding blastwaves, efficiently discovering off-axis events and probing the central engine at work, gravitational wave (GW) observations will soon revolutionize the study of gamma-ray bursts. Already, analyses of GW data targeting gamma-ray bursts have helped constrain the central engines of selected events. Advanced GW detectors with significantly improved sensitivities are under construction. After outlining the GW emission mechanisms from gamma-ray burst progenitors (binary coalescences, stellar core collapses, magnetars and others) that may be detectable with advanced detectors, we review how GWs will improve our understanding of gamma-ray burst central engines, their astrophysical formation channels and the prospects and methods for different search strategies. We place special emphasis on multimessenger searches. To achieve the most scientific benefit, GW, electromagnetic and neutrino observations should be combined to provide greater discriminating power and science reach.

Gamma Ray Imaging of Inertial Confinement Fusion Experiments

NASA Astrophysics Data System (ADS)

Wilde, Carl; Volegov, Petr; Geppert-Kleinrath, Verena; Danly, Christopher; Merrill, Frank; Simpson, Raspberry; Fittinghoff, David; Grim, Gary; NIF Nuclear Diagnostic Team Team; Advanced Imaging Team Team

2016-10-01

Experiments consisting of an ablatively driven plastic (CH) shell surrounding a deuterium tritium (DT) fuel region are routinely performed at the National Ignition Facility (NIF). Neutrons produced in the burning fuel in-elastically scatter with carbon atoms in the plastic shell producing 4.4 MeV gamma rays. Providing a spatially resolved distribution of the origin of these gammas can inform models of ablator physics and also provide a bounding volume for the cold fuel (un-burned DT fuel) region. Using the NIF neutron imaging system hardware, initial studies have been performed of the feasibility of imaging these gamma rays. A model of the system has been developed to inform under which experimental conditions this measurement can be made. Presented here is an analysis of the prospects for this diagnostic probe and a proposed set of modifications to the NIF neutron imaging line-of-site to efficiently enable this measurement.

Associated-particle sealed-tube neutron probe for characterization of materials

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rhodes, E.; Dickerman, C.E.; Peters, C.W.

1993-10-01

A neutron diagnostic probe system has been developed that can identify and image most elements having a larger atomic number than boron. It can satisfy van-mobile and fixed-portal requirements for nondestructive detection of contraband drugs, explosives, and nuclear and chemical warfare weapon materials, and for treaty verification of sealed munitions and remediation of radioactive waste. The probe is based on a nonpulsed associated-particle sealed-tube neutron generator (APSTNG) that interrogates the object with a 14-MeV neutrons and detects alpha-particle associated with each neutron. Gamma-ray spectra of resulting neutron reactions (primarily inelastic scattering) identify nuclides associated with drugs, explosives, and other contraband.more » Flight times determined from detection times of gamma-rays and alpha-particles yield a separate coarse tomographic image of each identified nuclide. Chemical substances are identified and imaged by comparing relative spectra fine intensities with ratios of elements in reference compounds. The High-energy neutrons in gamma-rays will penetrate large objects and dense materials. The source and emission detection systems can be on the same side, allowing measurements with access to one side only. A high signal-to-background ratio is obtained and maximum information is extracted from each detected gamma-ray, yet high-bandwidth data acquisition is not required. The APSTNG also forms the basis for a compact fast-neutron transmission imaging system. No collimators are required, and only minimal shielding is needed. The small and relatively inexpensive neutron generator tube exhibits high reliability and can be quickly replaced. The detector arrays and associated electronics can be made reliable with low maintenance cost.« less

Angular Distribution of Gamma-Ray Bursts: An Observational Probe of Cosmological Principle

NASA Astrophysics Data System (ADS)

Mészáros, A.; Balázs, L. G.; Vavrek, R.; Horváth, I.; Bagoly, Z.

The test of the isotropy in the angular distribution of the gamma-ray bursts collected in BATSE Catalog (Meegan C. A. et al., http://www.batse.msfc.nasa.gov/data, 2000) is a test of cosmological principle itself, because the gamma-ray bursts are at cosmological distances. Several articles of the authors study this question (Balázs L. G., Mészáros A., & Horváth I., Astron. Astrophys., 339, 1, 1998; Balázs L. G., Mészáros A., Horváth I., & Vavrek R., Astron. Astrophys. Suppl., 138, 417, 1999; Mészáros A., Bagoly Z., & Vavrek R. Astron. Astrophys., in press, 2000). The final conclusion concerning the validity of isotropy is complicated both by instrumental effects and by the fact that there are three subgroups of gamma-ray bursts ("short", "intermediate", "long"; separation is done with respect to the duration of bursts). The long bursts are surely up to z ≃ 4 (z is the redshift); for the remaining two subclasses the redshifts are unknown. The done tests of isotropy suggest (after the elimination of instrumental effects) the existence of anisotropy for the intermediate subclass on the confidence level > 95%. On the other hand, for the remaining two subclasses the situation is unclear; there is no unambiguous rejection of isotropy for them yet on the higher than 95% confidence level. If the bursts of intermediate subclass are at high z-s (say, at, z > 0.1), then the validity of cosmological principle would be at a serious doubt.

Automation system for measurement of gamma-ray spectra of induced activity for multi-element high volume neutron activation analysis at the reactor IBR-2 of Frank Laboratory of Neutron Physics at the joint institute for nuclear research

NASA Astrophysics Data System (ADS)

Pavlov, S. S.; Dmitriev, A. Yu.; Chepurchenko, I. A.; Frontasyeva, M. V.

2014-11-01

The automation system for measurement of induced activity of gamma-ray spectra for multi-element high volume neutron activation analysis (NAA) was designed, developed and implemented at the reactor IBR-2 at the Frank Laboratory of Neutron Physics. The system consists of three devices of automatic sample changers for three Canberra HPGe detector-based gamma spectrometry systems. Each sample changer consists of two-axis of linear positioning module M202A by DriveSet company and disk with 45 slots for containers with samples. Control of automatic sample changer is performed by the Xemo S360U controller by Systec company. Positioning accuracy can reach 0.1 mm. Special software performs automatic changing of samples and measurement of gamma spectra at constant interaction with the NAA database.

Optoacoustic temperature determination and automatic coagulation control in rabbits

NASA Astrophysics Data System (ADS)

Schlott, Kerstin; Koinzer, Stefan; Ptaszynski, Lars; Luft, Susanne; Baade, Alex; Bever, Marco; Roider, Johann; Birngruber, Reginald; Brinkmann, Ralf

2011-03-01

Retinal laser photocoagulation is an established treatment method for many retinal diseases like macula edema or diabetic retinopathy. The selection of the laser parameters is so far based on post treatment evaluation of the lesion size and strength. Due to local pigment variations in the fundus and individual transmission the same laser parameters often lead to an overtreatment. Optoacoustic allows a non invasive monitoring of the retinal temperature increase during retinal laser irradiation by measuring the temperature dependent pressure amplitudes, which are induced by short probe laser pulses. A 75 ns/ 523 nm Nd:YLF was used as a probe laser at a repetition rate of 1 kHz, and a cw / 532 nm treatment laser for heating. A contact lens was modified with a ring-shaped ultrasonic transducer to detect the pressure waves at the cornea. Temperatures were collected for irradiations leading to soft or invisible lesions. Based on this data the threshold for denaturation was found. By analyzing the initial temperature increase, the further temperature development during irradiation could be predicted. An algorithm was found to calculate the irradiation time, which is needed for a soft lesion formation, from the temperature curve. By this it was possible to provide a real-time dosimetry by automatically switching off the treatment laser after the calculated irradiation time. Automatically controlled coagulations appear softer and more uniformly.

The Advanced Gamma-ray Imaging System (AGIS)

NASA Astrophysics Data System (ADS)

Buckley, James

2008-04-01

We describe a concept for a ˜km^2 ground-based gamma-ray experiment (AGIS) comprised of an array of ˜100 imaging atmospheric Cherenkov telescopes achieving a sensitivity an order of magnitude better than the current generation of space or ground-based instruments in the energy range of 40 GeV to ˜100 TeV. We present the scientific drivers for AGIS including the prospects for contributions to understanding extragalactic sources such as nearby galaxies, active galaxies, galaxy clusters and GRB; galactic sources such as X-ray binaries, supernova remnants, and pulsar wind nebulae; as well as probes of fundamental physics including indirectly detecting dark matter and probing TeV-scale physics. With the current generation of atmospheric Cherenkov telescope arrays, TeV astronomy has become well established, with the number TeV gamma-ray sources now nearing 100, including many unidentified and serendipitous sources. Improvements in the instantaneous field of view, angular resolution, effective area and energy resolution of AGIS are certain to provide great scientific returns in high energy astrophysics as well as opening up new discovery space. Here we present an overview of the ongoing design studies for AGIS including the optimization of array parameters as well as an overview of the technical drivers for the observatory.

Assessment of right ventricular function with nonimaging first pass ventriculography and comparison of results with gamma camera studies.

PubMed

Zhang, Z; Liu, X J; Liu, Y Z; Lu, P; Crawley, J C; Lahiri, A

1990-08-01

A new technique has been developed for measuring right ventricular function by nonimaging first pass ventriculography. The right ventricular ejection fraction (RVEF) obtained by non-imaging first pass ventriculography was compared with that obtained by gamma camera first pass and equilibrium ventriculography. The data has demonstrated that the correlation of RVEFs obtained by the nonimaging nuclear cardiac probe and by gamma camera first pass ventriculography in 15 subjects was comparable (r = 0.93). There was also a good correlation between RVEFs obtained by the nonimaging nuclear probe and by equilibrium gated blood pool studies in 33 subjects (r = 0.89). RVEF was significantly reduced in 15 patients with right ventricular and/or inferior myocardial infarction compared to normal subjects (28 +/- 9% v. 45 +/- 9%). The data suggests that nonimaging probes may be used for assessing right ventricular function accurately.

Regulation of the steady state level of Fc gamma RI mRNA by IFN-gamma and dexamethasone in human monocytes, neutrophils, and U-937 cells.

PubMed

Pan, L Y; Mendel, D B; Zurlo, J; Guyre, P M

1990-07-01

The high affinity IgG FcR Fc gamma RI, CD64, plays important roles in the immune response. Fc gamma RI is predominantly expressed on monocytes and macrophages, and barely detectable on neutrophils. rIFN-gamma markedly increases the expression of Fc gamma RI on neutrophils, monocytes, macrophages and myeloid cell lines such as U-937, HL-60, and THP-1. Glucocorticoids inhibit the augmentation of Fc gamma RI expression by rIFN-gamma on neutrophils and myeloid cell lines, but enhance the augmentation of Fc gamma RI expression by rIFN-gamma on monocytes. In this study, we examined the effect of rIFN-gamma and dexamethasone (Dex) on the steady state level of Fc gamma RI mRNA in U-937 cells, neutrophils, and monocytes by hybridizing total RNA with the Fc gamma RI cDNA probe, p135. We found that the amount of Fc gamma RI mRNA increased within 1 h of treatment with rIFN-gamma in all three cell types. This initial induction of Fc gamma RI mRNA by rIFN-gamma was completely blocked by an inhibitor of RNA synthesis, actinomycin D, suggesting that the rIFN-gamma-mediated induction of Fc gamma RI mRNA is dependent on gene transcription. Dex, used in combination with rIFN-gamma, partially blocked the induction of Fc gamma RI mRNA by rIFN-gamma in U-937 cells and neutrophils, but caused a synergistic increase in Fc gamma RI mRNA levels in monocytes. The inhibitory effect of Dex on the steady state level of Fc gamma RI mRNA in U-937 cells was blocked by an inhibitor of protein synthesis, cycloheximide, suggesting that Dex-induced proteins were involved in the regulation of Fc gamma RI expression. This study indicates that the regulation of Fc gamma RI expression on U-937 cells, neutrophils, and monocytes by rIFN-gamma and Dex occurs, at least in part, at the mRNA level. rIFN-gamma increases the steady state level of Fc gamma RI mRNA through a common pathway among U-937 cells, neutrophils, and monocytes, whereas the effect of Dex on rIFN-gamma-induced Fc gamma RI mRNA is cell

An Analysis of the Utility of Handheld PET Probes for the Intraoperative Localization of Malignant Tissue

PubMed Central

González, Segundo Jaime; González, Lorena; Wong, Joyce; Brader, Peter; Zakowski, Maureen; Gönen, Mithat; Daghighian, Farhad; Fong, Yuman

2012-01-01

Introduction The intraoperative localization of suspicious lesions detected by positron emission tomography (PET) scan remains a challenge. To solve this, two novel probes have been created to accurately detect the 18F-FDG radiotracer intraoperatively. Methods Nude rats were inoculated with mesothelioma. When PET scans detected 10-mm tumors, animals were dissected and the PET probes analyzed the intraoperative radiotracer uptake of these lesions as tumor to background ratio (TBR). Results The 17 suspicious lesions seen on PET scan were localized intraoperatively (by their high TBR) using the PET probes and found malignant on pathology. Interestingly, smaller tumors not visualized on PET scan were detected intraoperatively by their high TBR and found malignant on pathology. Furthermore, using a TBR threshold as low as 2.0, both gamma (sensitivity, 100%; specificity, 80%; positive predictive value (PPV), 96%; and negative predictive value (NPV), 100%) and beta (sensitivity, 100%; specificity, 60%; PPV, 93%; and NPV, 100%) probes reliably detected suspicious lesions on PET scan imaging. They also showed an excellent area under the curve of 0.9 and 0.97 (95% CI of 0.81–0.99 and 0.93–1.0) for gamma and beta probes, respectively, in the receiver operating characteristic analysis for detecting malignancy. Conclusion This novel tool could be used synergistically with a PET scan imaging to maximize tissue selection intraoperatively. PMID:21108016

PROBING THE EXPANSION HISTORY OF THE UNIVERSE BY MODEL-INDEPENDENT RECONSTRUCTION FROM SUPERNOVAE AND GAMMA-RAY BURST MEASUREMENTS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Feng, Chao-Jun; Li, Xin-Zhou, E-mail: fengcj@shnu.edu.cn, E-mail: kychz@shnu.edu.cn

To probe the late evolution history of the universe, we adopt two kinds of optimal basis systems. One of them is constructed by performing the principle component analysis, and the other is built by taking the multidimensional scaling approach. Cosmological observables such as the luminosity distance can be decomposed into these basis systems. These basis systems are optimized for different kinds of cosmological models that are based on different physical assumptions, even for a mixture model of them. Therefore, the so-called feature space that is projected from the basis systems is cosmological model independent, and it provides a parameterization for studying and reconstructing themore » Hubble expansion rate from the supernova luminosity distance and even gamma-ray burst (GRB) data with self-calibration. The circular problem when using GRBs as cosmological candles is naturally eliminated in this procedure. By using the Levenberg–Marquardt technique and the Markov Chain Monte Carlo method, we perform an observational constraint on this kind of parameterization. The data we used include the “joint light-curve analysis” data set that consists of 740 Type Ia supernovae and 109 long GRBs with the well-known Amati relation.« less

Current gamma knife treatment for ophthalmic branch of primary trigeminal neuralgia

PubMed Central

Shan, Guo-Yong; Liang, Hao-Fang; Zhang, Jian-Hua

2011-01-01

AIM To probe into problems existing in gamma knife treatment of ophthalmic branch of primary trigeminal neuralgia (TN), and propose a safe and effective solution to the problem. METHODS Through sorting the literature reporting gamma knife treatment of refractory TN in recent years, this article analyzed the advantages and problems of gamma knife treatment of primary TN, and proposed reasonable assessment for existing problems and the possible solution. RESULTS Gamma knife treatment of TN has drawn increasing attention of clinicians due to its unique non-invasion, safety and effectiveness, but there are three related issues to be considered. The first one is the uncertainty of the optimal dose (70-90GY); the second one is the difference in radiotherapy target selection (using a single isocenter or two isocenters); and the third one is the big difference of recurrent pains (specific treatment methods need to be summarized and improved). CONCLUSION For patients with refractory TN, gamma knife treatment can be selected when the medical treatment fails or drug side effects emerge. The analysis of a large number of TN patients receiving gamma knife treatment has shown that this is a safe and effective treatment method. PMID:22553625

ProbFold: a probabilistic method for integration of probing data in RNA secondary structure prediction.

PubMed

Sahoo, Sudhakar; Świtnicki, Michał P; Pedersen, Jakob Skou

2016-09-01

Recently, new RNA secondary structure probing techniques have been developed, including Next Generation Sequencing based methods capable of probing transcriptome-wide. These techniques hold great promise for improving structure prediction accuracy. However, each new data type comes with its own signal properties and biases, which may even be experiment specific. There is therefore a growing need for RNA structure prediction methods that can be automatically trained on new data types and readily extended to integrate and fully exploit multiple types of data. Here, we develop and explore a modular probabilistic approach for integrating probing data in RNA structure prediction. It can be automatically trained given a set of known structures with probing data. The approach is demonstrated on SHAPE datasets, where we evaluate and selectively model specific correlations. The approach often makes superior use of the probing data signal compared to other methods. We illustrate the use of ProbFold on multiple data types using both simulations and a small set of structures with both SHAPE, DMS and CMCT data. Technically, the approach combines stochastic context-free grammars (SCFGs) with probabilistic graphical models. This approach allows rapid adaptation and integration of new probing data types. ProbFold is implemented in C ++. Models are specified using simple textual formats. Data reformatting is done using separate C ++ programs. Source code, statically compiled binaries for x86 Linux machines, C ++ programs, example datasets and a tutorial is available from http://moma.ki.au.dk/prj/probfold/ : jakob.skou@clin.au.dk Supplementary data are available at Bioinformatics online. © The Author 2016. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

Automatic sleep scoring: a search for an optimal combination of measures.

PubMed

Krakovská, Anna; Mezeiová, Kristína

2011-09-01

The objective of this study is to find the best set of characteristics of polysomnographic signals for the automatic classification of sleep stages. A selection was made from 74 measures, including linear spectral measures, interdependency measures, and nonlinear measures of complexity that were computed for the all-night polysomnographic recordings of 20 healthy subjects. The adopted multidimensional analysis involved quadratic discriminant analysis, forward selection procedure, and selection by the best subset procedure. Two situations were considered: the use of four polysomnographic signals (EEG, EMG, EOG, and ECG) and the use of the EEG alone. For the given database, the best automatic sleep classifier achieved approximately an 81% agreement with the hypnograms of experts. The classifier was based on the next 14 features of polysomnographic signals: the ratio of powers in the beta and delta frequency range (EEG, channel C3), the fractal exponent (EMG), the variance (EOG), the absolute power in the sigma 1 band (EEG, C3), the relative power in the delta 2 band (EEG, O2), theta/gamma (EEG, C3), theta/alpha (EEG, O1), sigma/gamma (EEG, C4), the coherence in the delta 1 band (EEG, O1-O2), the entropy (EMG), the absolute theta 2 (EEG, Fp1), theta/alpha (EEG, Fp1), the sigma 2 coherence (EEG, O1-C3), and the zero-crossing rate (ECG); however, even with only four features, we could perform sleep scoring with a 74% accuracy, which is comparable to the inter-rater agreement between two independent specialists. We have shown that 4-14 carefully selected polysomnographic features were sufficient for successful sleep scoring. The efficiency of the corresponding automatic classifiers was verified and conclusively demonstrated on all-night recordings from healthy adults. Copyright © 2011 Elsevier B.V. All rights reserved.

Estimate of true incomplete exchanges using fluorescence in situ hybridization with telomere probes

NASA Technical Reports Server (NTRS)

Wu, H.; George, K.; Yang, T. C.

1998-01-01

PURPOSE: To study the frequency of true incomplete exchanges in radiation-induced chromosome aberrations. MATERIALS AND METHODS: Human lymphocytes were exposed to 2 Gy and 5 Gy of gamma-rays. Chromosome aberrations were studied using the fluorescence in situ hybridization (FISH) technique with whole chromosome-specific probes, together with human telomere probes. Chromosomes 2 and 4 were chosen in the present study. RESULTS: The percentage of incomplete exchanges was 27% when telomere signals were not considered. After excluding false incomplete exchanges identified by the telomere signals, the percentage of incomplete exchanges decreased to 11%. Since telomere signals appear on about 82% of the telomeres, the percentage of true incomplete exchanges should be even lower and was estimated to be 3%. This percentage was similar for chromosomes 2 and 4 and for doses of both 2 Gy and 5 Gy. CONCLUSIONS: The percentage of true incomplete exchanges is significantly lower in gamma-irradiated human lymphocytes than the frequencies reported in the literature.

Atom Probe Tomography Analysis of the Distribution of Rhenium in Nickel Alloys

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mottura, A.; Warnken, N; Miller, Michael K

2010-01-01

Atom probe tomography (APT) is used to characterise the distributions of rhenium in a binary Ni-Re alloy and the nickel-based single-crystal CMSX-4 superalloy. A purpose-built algorithm is developed to quantify the size distribution of solute clusters, and applied to the APT datasets to critique the hypothesis that rhenium is prone to the formation of clusters in these systems. No evidence is found to indicate that rhenium forms solute clusters above the level expected from random fluctuations. In CMSX-4, enrichment of Re is detected in the matrix phase close to the matrix/precipitate ({gamma}/{gamma}{prime}) phase boundaries. Phase field modelling indicates that thismore » is due to the migration of the {gamma}/{gamma}{prime} interface during cooling from the temperature of operation. Thus, neither clustering of rhenium nor interface enrichments can be the cause of the enhancement in high temperature mechanical properties conferred by rhenium alloying.« less

Z{gamma}{gamma}{gamma} {yields} 0 Processes in SANC

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bardin, D. Yu., E-mail: bardin@nu.jinr.ru; Kalinovskaya, L. V., E-mail: kalinov@nu.jinr.ru; Uglov, E. D., E-mail: corner@nu.jinr.ru

2013-11-15

We describe the analytic and numerical evaluation of the {gamma}{gamma} {yields} {gamma}Z process cross section and the Z {yields} {gamma}{gamma}{gamma} decay rate within the SANC system multi-channel approach at the one-loop accuracy level with all masses taken into account. The corresponding package for numeric calculations is presented. For checking of the results' correctness we make a comparison with the other independent calculations.

Fast neutron-gamma discrimination on neutron emission profile measurement on JT-60U

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ishii, K.; Okamoto, A.; Kitajima, S.

2010-10-15

A digital signal processing (DSP) system is applied to stilbene scintillation detectors of the multichannel neutron emission profile monitor in JT-60U. Automatic analysis of the neutron-{gamma} pulse shape discrimination is a key issue to diminish the processing time in the DSP system, and it has been applied using the two-dimensional (2D) map. Linear discriminant function is used to determine the dividing line between neutron events and {gamma}-ray events on a 2D map. In order to verify the validity of the dividing line determination, the pulse shape discrimination quality is evaluated. As a result, the {gamma}-ray contamination in most of themore » beam heating phase was negligible compared with the statistical error with 10 ms time resolution.« less

MoonBEAM: A Beyond Earth-Orbit Gamma-Ray Burst Detector for Gravitational-Wave Astronomy

NASA Technical Reports Server (NTRS)

Hui, C. M.; Briggs, M. S.; Goldstein, A. M.; Jenke, P. A.; Kocevski, D.; Wilson-Hodge, C. A.

2018-01-01

Moon Burst Energetics All-sky Monitor (MoonBEAM) is a CubeSat concept of deploying gamma-ray detectors in cislunar space to improve localization precision for gamma-ray bursts by utilizing the light travel time difference between different orbits. We present here a gamma-ray SmallSat concept in Earth-Moon L3 halo orbit that is capable of rapid response and provide a timing baseline for localization improvement when partnered with an Earth-orbit instrument. Such an instrument would probe the extreme processes in cosmic collision of compact objects and facilitate multi-messenger time-domain astronomy to explore the end of stellar life cycles and black hole formations.

Priming production: Neural evidence for enhanced automatic semantic activity preceding language production in schizophrenia.

PubMed

Kuperberg, Gina R; Delaney-Busch, Nathaniel; Fanucci, Kristina; Blackford, Trevor

2018-01-01

Lexico-semantic disturbances are considered central to schizophrenia. Clinically, their clearest manifestation is in language production. However, most studies probing their underlying mechanisms have used comprehension or categorization tasks. Here, we probed automatic semantic activity prior to language production in schizophrenia using event-related potentials (ERPs). 19 people with schizophrenia and 16 demographically-matched healthy controls named target pictures that were very quickly preceded by masked prime words. To probe automatic semantic activity prior to production, we measured the N400 ERP component evoked by these targets. To determine the origin of any automatic semantic abnormalities, we manipulated the type of relationship between prime and target such that they overlapped in (a) their semantic features (semantically related, e.g. "cake" preceding a < picture of a pie >, (b) their initial phonemes (phonemically related, e.g. "stomach" preceding a < picture of a starfish >), or (c) both their semantic features and their orthographic/phonological word form (identity related, e.g. "socks" preceding a < picture of socks >). For each of these three types of relationship, the same targets were paired with unrelated prime words (counterbalanced across lists). We contrasted ERPs and naming times to each type of related target with its corresponding unrelated target. People with schizophrenia showed abnormal N400 modulation prior to naming identity related (versus unrelated) targets: whereas healthy control participants produced a smaller amplitude N400 to identity related than unrelated targets, patients showed the opposite pattern, producing a larger N400 to identity related than unrelated targets. This abnormality was specific to the identity related targets. Just like healthy control participants, people with schizophrenia produced a smaller N400 to semantically related than to unrelated targets, and showed no difference in the N400 evoked by

Probing the Cosmic Gamma-Ray Burst Rate with Trigger Simulations of the Swift Burst Alert Telescope

NASA Technical Reports Server (NTRS)

Lien, Amy; Sakamoto, Takanori; Gehrels, Neil; Palmer, David M.; Barthelmy, Scott D.; Graziani, Carlo; Cannizzo, John K.

2013-01-01

The gamma-ray burst (GRB) rate is essential for revealing the connection between GRBs, supernovae and stellar evolution. Additionally, the GRB rate at high redshift provides a strong probe of star formation history in the early universe. While hundreds of GRBs are observed by Swift, it remains difficult to determine the intrinsic GRB rate due to the complex trigger algorithm of Swift. Current studies of the GRB rate usually approximate the Swift trigger algorithm by a single detection threshold. However, unlike the previously own GRB instruments, Swift has over 500 trigger criteria based on photon count rate and additional image threshold for localization. To investigate possible systematic biases and explore the intrinsic GRB properties, we develop a program that is capable of simulating all the rate trigger criteria and mimicking the image threshold. Our simulations show that adopting the complex trigger algorithm of Swift increases the detection rate of dim bursts. As a result, our simulations suggest bursts need to be dimmer than previously expected to avoid over-producing the number of detections and to match with Swift observations. Moreover, our results indicate that these dim bursts are more likely to be high redshift events than low-luminosity GRBs. This would imply an even higher cosmic GRB rate at large redshifts than previous expectations based on star-formation rate measurements, unless other factors, such as the luminosity evolution, are taken into account. The GRB rate from our best result gives a total number of 4568 +825 -1429 GRBs per year that are beamed toward us in the whole universe.

Probing massive stars around gamma-ray burst progenitors

NASA Astrophysics Data System (ADS)

Lu, Wenbin; Kumar, Pawan; Smoot, George F.

2015-10-01

Long gamma-ray bursts (GRBs) are produced by ultra-relativistic jets launched from core collapse of massive stars. Most massive stars form in binaries and/or in star clusters, which means that there may be a significant external photon field (EPF) around the GRB progenitor. We calculate the inverse-Compton scattering of EPF by the hot electrons in the GRB jet. Three possible cases of EPF are considered: the progenitor is (I) in a massive binary system, (II) surrounded by a Wolf-Rayet-star wind and (III) in a dense star cluster. Typical luminosities of 1046-1050 erg s-1 in the 1-100 GeV band are expected, depending on the stellar luminosity, binary separation (I), wind mass-loss rate (II), stellar number density (III), etc. We calculate the light curve and spectrum in each case, taking fully into account the equal-arrival time surfaces and possible pair-production absorption with the prompt γ-rays. Observations can put constraints on the existence of such EPFs (and hence on the nature of GRB progenitors) and on the radius where the jet internal dissipation process accelerates electrons.

Sizing up the population of gamma-ray binaries

NASA Astrophysics Data System (ADS)

Dubus, Guillaume; Guillard, Nicolas; Petrucci, Pierre-Olivier; Martin, Pierrick

2017-12-01

Context. Gamma-ray binaries are thought to be composed of a young pulsar in orbit around a massive O or Be star with their gamma-ray emission powered by pulsar spin-down. The number of such systems in our Galaxy is not known. Aims: We aim to estimate the total number of gamma-ray binaries in our Galaxy and to evaluate the prospects for new detections in the GeV and TeV energy range, taking into account that their gamma-ray emission is modulated on the orbital period. Methods: We modelled the population of gamma-ray binaries and evaluated the fraction of detected systems in surveys with the Fermi-LAT (GeV), H.E.S.S., HAWC and CTA (TeV) using observation-based and synthetic template light curves. Results: The detected fraction depends more on the orbit-average flux than on the light-curve shape. Our best estimate for the number of gamma-ray binaries is 101-52+89 systems. A handful of discoveries are expected by pursuing the Fermi-LAT survey. Discoveries in TeV surveys are less likely. However, this depends on the relative amounts of power emitted in GeV and TeV domains. There could be as many as ≈ 200 HESS J0632+057-like systems with a high ratio of TeV to GeV emission compared to other gamma-ray binaries. Statistics allow for as many as three discoveries in five years of HAWC observations and five discoveries in the first two years of the CTA Galactic Plane survey. Conclusions: We favour continued Fermi-LAT observations over ground-based TeV surveys to find new gamma-ray binaries. Gamma-ray observations are most sensitive to short orbital period systems with a high spin-down pulsar power. Radio pulsar surveys (SKA) are likely to be more efficient in detecting long orbital period systems, providing a complementary probe into the gamma-ray binary population.

Standardization of the neutron probe for the assessment of masonry deterioration

DOE Office of Scientific and Technical Information (OSTI.GOV)

Livingston, R.A.

1992-01-01

The repair of the infrastructure will require nondestructive methods to assess the condition of existing buildings and other structures, many of which are constructed of masonry. One possible technology is the neutron probe, a prompt-gamma neutron activation (PGNA) technique that can perform non- destructive elemental analyses in the field. It is based on a very low intensity [sup 252]Cf neutron source and a high-purity germanium detector for the gamma rays emitted by neutron capture within the material. The thermal neutron capture cross sections for hydrogen and chlorine are very large, and in masonry, these elements are found primarily in moisturemore » and chlorides. These are major causes of deterioration in porous materials such as brick masonry. The moisture damages the material through expansive stresses during freeze-thaw cycles. Chlorides also generate expansive stresses through periodic cycles of dissolution and recrystallization in response to relative humidity cycles in the atmosphere. Similar problems also occur in reinforced concrete, where chlorides cause additional damage through corrosion of the reinforcing steel. The sensitivity of the neutron probe to hydrogen and chlorine thus means it can be used to map the distribution of these agents of deterioration. Preliminary field work at Colonial Williamsburg and Venice, Italy, showed that the technique could yield useful qualitative information. However, to be a quantitative method, the neutron probe had to be standardized in the laboratory on materials of known composition and specified moisture and chloride content.« less

Blazar Gamma-Rays, Shock Acceleration, and the Extragalactic Background Light

NASA Technical Reports Server (NTRS)

Stecker, Floyd W.; Baring, Matthew G.; Summerlin, Errol J.

2007-01-01

The observed spectra of blazars, their intrinsic emission, and the underlying populations of radiating particles are intimately related. The use of these sources as probes of the extragalactic infrared background, a prospect propelled by recent advances in TeV-band telescopes, soon to be augmented by observations by NASA's upcoming Gamma-Ray Large Area Space Telescope (GLAST), has been a topic of great recent interest. Here, it is demonstrated that if particles in blazar jets are accelerated at relativistic shocks, then GAMMA-ray spectra with indices less than 1.5 can be produced. This, in turn, loosens the upper limits on the near infrared extragalactic background radiation previously proposed. We also show evidence hinting that TeV blazars with flatter spectra have higher intrinsic TeV GAMMA-ray luminosities and we indicate that there may be a correlation of flatness and luminosity with redshift.

The Z {yields} cc-bar {yields} {gamma}{gamma}*, Z {yields} bb-bar {yields} {gamma}{gamma}* triangle diagrams and the Z {yields} {gamma}{psi}, Z {yields} {gamma}Y decays

DOE Office of Scientific and Technical Information (OSTI.GOV)

Achasov, N. N., E-mail: achasov@math.nsc.ru

2011-03-15

The approach to the Z {yields} {gamma}{psi} and Z {yields} {gamma}Y decay study is presented in detail, based on the sum rules for the Z {yields} cc-bar {yields} {gamma}{gamma}* and Z {yields} bb-bar {yields} {gamma}{gamma}* amplitudes and their derivatives. The branching ratios of the Z {yields} {gamma}{psi} and Z {yields} {gamma}Y decays are calculated for different hypotheses on saturation of the sum rules. The lower bounds of {Sigma}{sub {psi}} BR(Z {yields} {gamma}{psi}) = 1.95 Multiplication-Sign 10{sup -7} and {Sigma}{sub {upsilon}} BR(Z {yields} {gamma}Y) = 7.23 Multiplication-Sign 10{sup -7} are found. Deviations from the lower bounds are discussed, including the possibilitymore » of BR(Z {yields} {gamma}J/{psi}(1S)) {approx} BR(Z {yields} {gamma}Y(1S)) {approx} 10{sup -6}, that could be probably measured in LHC. The angular distributions in the Z {yields} {gamma}{psi} and Z {yields} {gamma}Y decays are also calculated.« less

Gamma-ray Burst and Gravitational Wave Counterpart Prospects in the MeV Band with AMEGO

NASA Astrophysics Data System (ADS)

Racusin, Judith; AMEGO Team

2018-01-01

The All-sky Medium Energy Gamma-ray Observatory (AMEGO) Probe mission concept is uniquely suited to address open questions in Gamma-ray Burst (GRB) science including the search for counterparts to gravitational-wave events. AMEGO is a wide field of view instrument (~60 deg radius) with a broad energy range (~200 keV to >10 GeV) and excellent continuum sensitivity. The sensitivity improvement will allow for probes of GRB emission mechanisms and jet composition in ways that have not been accessible with previous instruments. Potential for polarization measurement may also have profound impacts on the understanding of GRB mechanisms. AMEGO will also be an excellent facility for the search for gravitational wave counterparts to binary mergers including at least one neutron star, which are thought to produce short duration GRBs. This poster will describe how the AMEGO will advance these fields.

Positron Annihilation Induced Auger and Gamma Spectroscopy of Catalytically Important Surfaces

NASA Astrophysics Data System (ADS)

Weiss, A. H.; Nadesalingam, M. P.; Sundaramoorthy, R.; Mukherjee, S.; Fazleev, N. G.

2006-10-01

The annihilation of positrons with core electrons results in unique signatures in the spectra of Auger-electron and annihilation-gamma rays that can be used to make clear chemical identification of atoms at the surface. Because positrons implanted at low energies are trapped with high efficiency in the image-correlation well where they are localized just outside the surface it is possible to use annihilation induced Auger and Gamma signals to probe the surfaces of solids with single atomic layer depth resolution. In this talk we will report recent applications of Positron Annihilation Induced Auger Electron Spectroscopy (PAES) and Auger-Gamma Coincidence Spectroscopy (AGCS) to the study of surface structure and surface chemistry. Our research has demonstrated that PAES spectra can provide new information regarding the composition of the top-most atomic layer. Applications of PAES to the study of catalytically important surfaces of oxides and wide band-gap semiconductors including TiO2, SiO2,Cu2O, and SiC will be presented. We conclude with a discussion of the use of Auger-Gamma and Gamma-Gamma coincidence spectroscopy for the study of surfaces at pressures closer to those found in practical chemical reactors. Research supported by the Welch Foundation Grant Number Y-1100.

Evaluation of a CdTe semiconductor based compact gamma camera for sentinel lymph node imaging

DOE Office of Scientific and Technical Information (OSTI.GOV)

Russo, Paolo; Curion, Assunta S.; Mettivier, Giovanni

2011-03-15

Purpose: The authors assembled a prototype compact gamma-ray imaging probe (MediPROBE) for sentinel lymph node (SLN) localization. This probe is based on a semiconductor pixel detector. Its basic performance was assessed in the laboratory and clinically in comparison with a conventional gamma camera. Methods: The room-temperature CdTe pixel detector (1 mm thick) has 256x256 square pixels arranged with a 55 {mu}m pitch (sensitive area 14.08x14.08 mm{sup 2}), coupled pixel-by-pixel via bump-bonding to the Medipix2 photon-counting readout CMOS integrated circuit. The imaging probe is equipped with a set of three interchangeable knife-edge pinhole collimators (0.94, 1.2, or 2.1 mm effective diametermore » at 140 keV) and its focal distance can be regulated in order to set a given field of view (FOV). A typical FOV of 70 mm at 50 mm skin-to-collimator distance corresponds to a minification factor 1:5. The detector is operated at a single low-energy threshold of about 20 keV. Results: For {sup 99m}Tc, at 50 mm distance, a background-subtracted sensitivity of 6.5x10{sup -3} cps/kBq and a system spatial resolution of 5.5 mm FWHM were obtained for the 0.94 mm pinhole; corresponding values for the 2.1 mm pinhole were 3.3x10{sup -2} cps/kBq and 12.6 mm. The dark count rate was 0.71 cps. Clinical images in three patients with melanoma indicate detection of the SLNs with acquisition times between 60 and 410 s with an injected activity of 26 MBq {sup 99m}Tc and prior localization with standard gamma camera lymphoscintigraphy. Conclusions: The laboratory performance of this imaging probe is limited by the pinhole collimator performance and the necessity of working in minification due to the limited detector size. However, in clinical operative conditions, the CdTe imaging probe was effective in detecting SLNs with adequate resolution and an acceptable sensitivity. Sensitivity is expected to improve with the future availability of a larger CdTe detector permitting operation at

Disentangling the gamma-ray emission towards Cygnus X: Sh2-104

NASA Astrophysics Data System (ADS)

Gotthelf, Eric

2015-09-01

We have just discovered distinct X-ray emission coincident with VER J2018+363, a TeV source recently resolved from the giant gamma-ray complex MGRO J2019+37 in the Cygnus region. NuSTAR reveals a hard point source and a diffuse nebula adjacent to and possibly part of Sh2-104, a compact HII region containing several young massive stellar clusters. There is reasonable evidence that these X-rays probe the origin of the gamma-ray flux, however, unrelated extragalactic sources need to be excluded. We propose a short Chandra observation to localize the X-ray emission to identify a putative pulsar or stellar counterpart(s). This is an important step to fully understand the energetics of the MGRO J2019+37 complex and the production of gamma-rays in star formation regions, in general.

Supervised Gamma Process Poisson Factorization

DOE Office of Scientific and Technical Information (OSTI.GOV)

Anderson, Dylan Zachary

This thesis develops the supervised gamma process Poisson factorization (S- GPPF) framework, a novel supervised topic model for joint modeling of count matrices and document labels. S-GPPF is fully generative and nonparametric: document labels and count matrices are modeled under a uni ed probabilistic framework and the number of latent topics is controlled automatically via a gamma process prior. The framework provides for multi-class classification of documents using a generative max-margin classifier. Several recent data augmentation techniques are leveraged to provide for exact inference using a Gibbs sampling scheme. The first portion of this thesis reviews supervised topic modeling andmore » several key mathematical devices used in the formulation of S-GPPF. The thesis then introduces the S-GPPF generative model and derives the conditional posterior distributions of the latent variables for posterior inference via Gibbs sampling. The S-GPPF is shown to exhibit state-of-the-art performance for joint topic modeling and document classification on a dataset of conference abstracts, beating out competing supervised topic models. The unique properties of S-GPPF along with its competitive performance make it a novel contribution to supervised topic modeling.« less

Novel Handheld Magnetometer Probe Based on Magnetic Tunnelling Junction Sensors for Intraoperative Sentinel Lymph Node Identification

PubMed Central

Cousins, A.; Balalis, G. L.; Thompson, S. K.; Forero Morales, D.; Mohtar, A.; Wedding, A. B.; Thierry, B.

2015-01-01

Using magnetic tunnelling junction sensors, a novel magnetometer probe for the identification of the sentinel lymph node using magnetic tracers was developed. Probe performance was characterised in vitro and validated in a preclinical swine model. Compared to conventional gamma probes, the magnetometer probe showed excellent spatial resolution of 4.0 mm, and the potential to detect as few as 5 μg of magnetic tracer. Due to the high sensitivity of the magnetometer, all first-tier nodes were identified in the preclinical experiments, and there were no instances of false positive or false negative detection. Furthermore, these preliminary data encourage the application of the magnetometer probe for use in more complex lymphatic environments, such as in gastrointestinal cancers, where the sentinel node is often in close proximity to other non-sentinel nodes, and high spatial resolution detection is required. PMID:26038833

A nonimaging scintillation probe to measure penile hemodynamics.

PubMed

Zuckier, L S; Korupolu, G R; Gladshteyn, M; Sattenberg, R; Goldstein, R; Ricciardi, R; Goodwin, P; Melman, A; Blaufox, M D

1995-12-01

We have developed a penile nonimaging scintillation (PNIS) probe consisting of a plastic well-type scintillation crystal interfaced to a portable computer and acquisition board. This report describes the design of the PNIS probe, performance characteristics, mode of usage and illustrative results which demonstrate its capabilities. With the PNIS probe, penile blood-pool studies were performed in nine patients utilizing 3.7 MBq (100 microCi) autologous 99mTc-labeled red blood cells (RBCs). Venous blood standards were assayed to enable conversion of the count rate to volummetric measurements. Washin of peripherally administered 99mTc-RBCs was mathematically analyzed to estimate penile blood volume and cavernosal flow rate in the flaccid state. The rate of change of penile blood volume after intracavernosal vasodilators was used to generate measures of stimulated flow. A major advantage of this device over the gamma-camera is a 3300-fold increase in count rate sensitivity, which allows for markedly improved temporal resolution while significantly reducing the radiopharmaceutical dosage. Additionally, the PNIS probe is portable, economical and is not dependent on operator-defined regions of interest. Count rate sensitivity is relatively constant within the bore, with the exception of the proximal region adjacent to the opening, where geometric efficiency is reduced. The PNIS probe is an effective device for measuring penile activity in radionuclide studies, allowing for acquisition of time-activity curves of the penis during flaccid washin of peripherally labeled red blood cells and after pharmacologic stimulation to induce erection.

The Relative Effects of Manual Versus Automatic Exposure Control on Radiation Dose to Vital Organs in Total Hip Arthroplasty.

PubMed

Harper, Katharine D; Li, Shidong; Jennings, Rachel; Amer, Kamil M; Haydel, Christopher; Ali, Sayed

2018-01-01

Technologic advances have reduced medical radiation exposure while maintaining image quality. The purpose of this study was to determine the effects of the presence of total hip arthroplasty implants, compared with native hips, on radiation exposure of the most radiosensitive organs when manual and automatic exposure control settings are used. Detection probes were placed at six locations (stomach, sigmoid colon, right pelvic wall, left pelvic wall, pubic symphysis, and anterior pubic skin) in a cadaver. Radiographs were obtained with the use of manual and automatic exposure control protocols, with exposures recorded. A total hip arthroplasty implant was placed in the cadaver, probe positioning was confirmed, and the radiographs were repeated, with exposure values recorded. The control probe placed at the stomach had values ranging from 0.00 mSv to 0.01 mSv in protocols with and without implants. With the manual protocol, exposures in the pelvis ranged from 0.36 mSv to 2.74 mSv in the native hip and from 0.33 mSv to 2.24 mSv after implant placement. The increases in exposure after implant placement, represented as relative risk, were as follows: stomach, 1.000; pubic symphysis, 0.818; left pelvic wall, 1.381; sigmoid colon, 1.550; right pelvic wall, 0.917; and anterior pubic skin, 1.015. With automatic exposure control, exposures in the pelvis ranged from 0.07 mSv to 0.89 mSv in the native hip and from 0.21 mSv to 1.15 mSv after implant placement. With automatic exposure control, the increases in exposure after implant placement, represented as relative risk, were as follows: stomach, 1.000; pubic symphysis, 1.292; left pelvic wall, 1.476; sigmoid colon, 2.182; right pelvic wall, 3.000; and anterior pubic skin, 1.378. The amount of radiation to which patients are exposed as a result of medical procedures or imaging, and whether exposure is associated with an increased risk of malignant transformation, are the subject of ongoing debate. We found that after insertion

Gamma-ray bursts and their use as cosmic probes

PubMed Central

2017-01-01

Since the launch of the highly successful and ongoing Swift mission, the field of gamma-ray bursts (GRBs) has undergone a revolution. The arcsecond GRB localizations available within just a few minutes of the GRB alert has signified the continual sampling of the GRB evolution through the prompt to afterglow phases revealing unexpected flaring and plateau phases, the first detection of a kilonova coincident with a short GRB, and the identification of samples of low-luminosity, ultra-long and highly dust-extinguished GRBs. The increased numbers of GRB afterglows, GRB-supernova detections, redshifts and host galaxy associations has greatly improved our understanding of what produces and powers these immense, cosmological explosions. Nevertheless, more high-quality data often also reveal greater complexity. In this review, I summarize some of the milestones made in GRB research during the Swift era, and how previous widely accepted theoretical models have had to adapt to accommodate the new wealth of observational data. PMID:28791158

Dual-modality imaging with a ultrasound-gamma device for oncology

NASA Astrophysics Data System (ADS)

Polito, C.; Pellegrini, R.; Cinti, M. N.; De Vincentis, G.; Lo Meo, S.; Fabbri, A.; Bennati, P.; Cencelli, V. Orsolini; Pani, R.

2018-06-01

Recently, dual-modality systems have been developed, aimed to correlate anatomical and functional information, improving disease localization and helping oncological or surgical treatments. Moreover, due to the growing interest in handheld detectors for preclinical trials or small animal imaging, in this work a new dual modality integrated device, based on a Ultrasounds probe and a small Field of View Single Photon Emission gamma camera, is proposed.

Precision investigations of nuclei and nucleons with the (e, e'. gamma. ) reaction

DOE Office of Scientific and Technical Information (OSTI.GOV)

Papanicolas, C.N.; Ammons, E.A.; Cardman, L.S.

1988-11-20

Recent theoretical and experimental investigations of the (e, e'..gamma..) reaction show that it provides a probe of unparalleled precision and selectivity. Experiments aimed towards the isolation of multipole form factors in mixed transitions, the study of continuum excitations in nuclei, and the measurement of the response of the proton are underway at several laboratories.

A new population of very high energy gamma-ray sources in the Milky Way.

PubMed

Aharonian, F; Akhperjanian, A G; Aye, K-M; Bazer-Bachi, A R; Beilicke, M; Benbow, W; Berge, D; Berghaus, P; Bernlöhr, K; Boisson, C; Bolz, O; Borgmeier, C; Braun, I; Breitling, F; Brown, A M; Gordo, J Bussons; Chadwick, P M; Chounet, L-M; Cornils, R; Costamante, L; Degrange, B; Djannati-Ataï, A; Drury, L O'C; Dubus, G; Ergin, T; Espigat, P; Feinstein, F; Fleury, P; Fontaine, G; Funk, S; Gallant, Y A; Giebels, B; Gillessen, S; Goret, P; Hadjichristidis, C; Hauser, M; Heinzelmann, G; Henri, G; Hermann, G; Hinton, J A; Hofmann, W; Holleran, M; Horns, D; de Jager, O C; Jung, I; Khélifi, B; Komin, Nu; Konopelko, A; Latham, I J; Le Gallou, R; Lemière, A; Lemoine, M; Leroy, N; Lohse, T; Marcowith, A; Masterson, C; McComb, T J L; de Naurois, M; Nolan, S J; Noutsos, A; Orford, K J; Osborne, J L; Ouchrif, M; Panter, M; Pelletier, G; Pita, S; Pühlhofer, G; Punch, M; Raubenheimer, B C; Raue, M; Raux, J; Rayner, S M; Redondo, I; Reimer, A; Reimer, O; Ripken, J; Rob, L; Rolland, L; Rowell, G; Sahakian, V; Saugé, L; Schlenker, S; Schlickeiser, R; Schuster, C; Schwanke, U; Siewert, M; Sol, H; Steenkamp, R; Stegmann, C; Tavernet, J-P; Terrier, R; Théoret, C G; Tluczykont, M; van der Walt, D J; Vasileiadis, G; Venter, C; Vincent, P; Visser, B; Völk, H J; Wagner, S J

2005-03-25

Very high energy gamma-rays probe the long-standing mystery of the origin of cosmic rays. Produced in the interactions of accelerated particles in astrophysical objects, they can be used to image cosmic particle accelerators. A first sensitive survey of the inner part of the Milky Way with the High Energy Stereoscopic System (HESS) reveals a population of eight previously unknown firmly detected sources of very high energy gamma-rays. At least two have no known radio or x-ray counterpart and may be representative of a new class of "dark" nucleonic cosmic ray sources.

Probing the cosmic gamma-ray burst rate with trigger simulations of the swift burst alert telescope

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lien, Amy; Cannizzo, John K.; Sakamoto, Takanori

The gamma-ray burst (GRB) rate is essential for revealing the connection between GRBs, supernovae, and stellar evolution. Additionally, the GRB rate at high redshift provides a strong probe of star formation history in the early universe. While hundreds of GRBs are observed by Swift, it remains difficult to determine the intrinsic GRB rate due to the complex trigger algorithm of Swift. Current studies of the GRB rate usually approximate the Swift trigger algorithm by a single detection threshold. However, unlike the previously flown GRB instruments, Swift has over 500 trigger criteria based on photon count rate and an additional imagemore » threshold for localization. To investigate possible systematic biases and explore the intrinsic GRB properties, we develop a program that is capable of simulating all the rate trigger criteria and mimicking the image threshold. Our simulations show that adopting the complex trigger algorithm of Swift increases the detection rate of dim bursts. As a result, our simulations suggest that bursts need to be dimmer than previously expected to avoid overproducing the number of detections and to match with Swift observations. Moreover, our results indicate that these dim bursts are more likely to be high redshift events than low-luminosity GRBs. This would imply an even higher cosmic GRB rate at large redshifts than previous expectations based on star formation rate measurements, unless other factors, such as the luminosity evolution, are taken into account. The GRB rate from our best result gives a total number of 4568{sub −1429}{sup +825} GRBs per year that are beamed toward us in the whole universe.« less

Probing Cosmic Star Formation Using Long Gamma-Ray Bursts: New Constraints from the Spitzer Space Telescope

NASA Astrophysics Data System (ADS)

Le Floc'h, Emeric; Charmandaris, Vassilis; Forrest, William J.; Mirabel, I. Félix; Armus, Lee; Devost, Daniel

2006-05-01

We report on IRAC 4.5 μm, IRAC 8.0 μm, and MIPS 24 μm deep observations of 16 gamma-ray burst (GRB) host galaxies performed with the Spitzer Space Telescope, and we investigate in the thermal infrared the presence of evolved stellar populations and dust-enshrouded star-forming activity associated with these objects. Our sample is derived from GRBs that were identified with subarcsecond localization between 1997 and 2001, and only a very small fraction (~20%) of the targeted sources are detected down to f4.5μm~3.5 μJy and f24μm~85 μJy (3 σ). This likely argues against a population dominated by massive and strongly starbursting (i.e., SFR>~100 Msolar yr-1) galaxies as has been recently suggested from submillimeter/radio and optical studies of similarly selected GRB hosts. Furthermore, we find evidence that some GRBs do not occur in the most infrared luminous regions-hence the most actively star-forming environments-of their host galaxies. Should the GRB hosts be representative of all star-forming galaxies at high redshift, models of infrared galaxy evolution indicate that >~50% of GRB hosts should have f24μm>~100 μJy. Unless the identification of GRBs prior to 2001 was prone to strong selection effects biasing our sample against dusty galaxies, we infer in this context that the GRBs identified with the current techniques cannot be directly used as unbiased probes of the global and integrated star formation history of the universe. Based on observations made with the Spitzer Space Telescope, operated by the Jet Propulsion Laboratory under NASA contract 1407.

Fully automatic region of interest selection in glomerular filtration rate estimation from 99mTc-DTPA renogram.

PubMed

Lin, Kun-Ju; Huang, Jia-Yann; Chen, Yung-Sheng

2011-12-01

Glomerular filtration rate (GFR) is a common accepted standard estimation of renal function. Gamma camera-based methods for estimating renal uptake of (99m)Tc-diethylenetriaminepentaacetic acid (DTPA) without blood or urine sampling have been widely used. Of these, the method introduced by Gates has been the most common method. Currently, most of gamma cameras are equipped with a commercial program for GFR determination, a semi-quantitative analysis by manually drawing region of interest (ROI) over each kidney. Then, the GFR value can be computed from the scintigraphic determination of (99m)Tc-DTPA uptake within the kidney automatically. Delineating the kidney area is difficult when applying a fixed threshold value. Moreover, hand-drawn ROIs are tedious, time consuming, and dependent highly on operator skill. Thus, we developed a fully automatic renal ROI estimation system based on the temporal changes in intensity counts, intensity-pair distribution image contrast enhancement method, adaptive thresholding, and morphological operations that can locate the kidney area and obtain the GFR value from a (99m)Tc-DTPA renogram. To evaluate the performance of the proposed approach, 30 clinical dynamic renograms were introduced. The fully automatic approach failed in one patient with very poor renal function. Four patients had a unilateral kidney, and the others had bilateral kidneys. The automatic contours from the remaining 54 kidneys were compared with the contours of manual drawing. The 54 kidneys were included for area error and boundary error analyses. There was high correlation between two physicians' manual contours and the contours obtained by our approach. For area error analysis, the mean true positive area overlap is 91%, the mean false negative is 13.4%, and the mean false positive is 9.3%. The boundary error is 1.6 pixels. The GFR calculated using this automatic computer-aided approach is reproducible and may be applied to help nuclear medicine physicians in

Field-deployable gamma-radiation detectors for DHS use

NASA Astrophysics Data System (ADS)

Mukhopadhyay, Sanjoy

2007-09-01

Recently, the Department of Homeland Security (DHS) has integrated all nuclear detection research, development, testing, evaluation, acquisition, and operational support into a single office: the Domestic Nuclear Detection Office (DNDO). The DNDO has specific requirements set for all commercial off-the-shelf and government off-the-shelf radiation detection equipment and data acquisition systems. This article would investigate several recent developments in field deployable gamma radiation detectors that are attempting to meet the DNDO specifications. Commercially available, transportable, handheld radio isotope identification devices (RIID) are inadequate for DHS' requirements in terms of sensitivity, resolution, response time, and reach-back capability. The leading commercial vendor manufacturing handheld gamma spectrometer in the United States is Thermo Electron Corporation. Thermo Electron's identiFINDER TM, which primarily uses sodium iodide crystals (3.18 x 2.54cm cylinders) as gamma detectors, has a Full-Width-at-Half-Maximum energy resolution of 7 percent at 662 keV. Thermo Electron has just recently come up with a reach-back capability patented as RadReachBack TM that enables emergency personnel to obtain real-time technical analysis of radiation samples they find in the field1. The current project has the goal to build a prototype handheld gamma spectrometer, equipped with a digital camera and an embedded cell phone to be used as an RIID with higher sensitivity, better resolution, and faster response time (able to detect the presence of gamma-emitting radio isotopes within 5 seconds of approach), which will make it useful as a field deployable tool. The handheld equipment continuously monitors the ambient gamma radiation, and, if it comes across any radiation anomalies with higher than normal gamma gross counts, it sets an alarm condition. When a substantial alarm level is reached, the system automatically triggers the saving of relevant spectral data and

Chromium and Tantalum Site Substitution Patterns in Ni3Al (L1(sub 2))gamma(prime)- Precipitates

NASA Technical Reports Server (NTRS)

Booth-Morrison, Christopher; Mao, Zugang; Seidman, David N.; Noebe, Ronald D.

2008-01-01

The site substitution behavior of Cr and Ta in the Ni3Al (Ll2)-type gamma'-precipitates of a Ni-Al-Cr-Ta alloy is investigated by atom-probe tomography (APT) and first-principles calculations. Measurements of the gamma'-phase composition by APT suggest that Al, Cr, and Ta share the Al sublattice sites of the gamma'-precipitates. The calculated substitutional energies of the solute atoms at the Ni and Al sublattice sites indicate that Ta has a strong preference for the Al sites, while Cr has a weak Al site preference. Furthermore, Ta is shown to replace Cr at the Al sublattice sites of the gamma'-precipitates, altering the elemental phase partitioning behavior of the Ni-Al-Cr-Ta alloy.

Simultaneous observation of the gamma-ray binary LS I+61 303 with GLAST and Suzaku

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tanaka, Takuya; Fukazawa, Yasushi; Mizuno, Tsunefumi

2007-07-12

The gamma-ray binary LS I+61 303 is a bright gamma-ray source, and thus an attracting object for GLAST. We proposed to observe this object with the X-ray satellite Suzaku (AO-2), simultaneously with GLAST, radio wave, and optical spectro-polarimetry, in order to probe the geometrical state of the binary system emitting the gamma-ray radiation, as a function of the binary orbital phase for the first time. This is essential to understand the mechanism of jet production and gamma-ray emission. The idea is not only to measure the multi-band overall continuum shape, but also to make use of continuous monitoring capability ofmore » GLAST, wide X-ray band of Suzaku, and good accessibility of the Kanata optical/NIR telescope (Hiroshima University) with the sensitive optical spectro-polarimetry. Further collaboration with TeV gamma-ray telescopes is also hoped to constrain the jet constitution.« less

Automatic real-time control of suspended sediment based upon high frequency in situ measurements of nephelometric turbidity

Treesearch

Jack Lewis; Rand Eads

1998-01-01

Abstract - For estimating suspended sediment concentration (SSC) in rivers, turbidity is potentially a much better predictor than water discharge. Since about 1990, it has been feasible to automatically collect high frequency turbidity data at remote sites using battery-powered turbidity probes that are properly mounted in the river or stream. With sensors calibrated...

Automatic Imitation

ERIC Educational Resources Information Center

Heyes, Cecilia

2011-01-01

"Automatic imitation" is a type of stimulus-response compatibility effect in which the topographical features of task-irrelevant action stimuli facilitate similar, and interfere with dissimilar, responses. This article reviews behavioral, neurophysiological, and neuroimaging research on automatic imitation, asking in what sense it is "automatic"…

Design of an Operando Positron Annihilation Gamma Spectrometer (OPAGS)

NASA Astrophysics Data System (ADS)

Satyal, Suman; Shastry, Kartik; Kalaskar, Sushant; Lim, Larry; Joglekar, Vibek; Weiss, Alexander

2009-10-01

Surface properties measured under UHV conditions cannot be extended to surfaces interacting with gases under realistic pressures due to surface reconstruction and other strong perturbations of the surface. Many surface probing techniques used till now have required UHV conditions to avoid data loss due to scattering of outgoing particles. Here we describe the design of an Operando Positron Annihilation Gamma Spectrometer (OPAGS) currently under construction at the University of Texas at Arlington. The new system will be capable of obtaining surface and defect specific chemical and charge state information from surfaces under realistic pressures. Differential pumping will be used to maintain the sample in a gas environment while the rest of the beam is under UHV. The Elemental content of the surface interacting with the gas environment will be determined from the Doppler broadened gamma spectra. This system will also include a time of flight (TOF) positron annihilation induced Auger spectrometer (TOF-PAES) for use in combined annihilation induced Auger and annihilation gamma measurements made under low pressure conditions.

Development of support system to handle ultrasound probe by coordinated motion with medical robot.

PubMed

Masuda, Kohji; Takachi, Yuuki; Urayama, Yasuhiro; Yoshinaga, Takashi

2011-01-01

We have developed a support system using our ultrasound diagnosis robot, which is able to support manual handling of ultrasound probe in echography to alleviate fatigue of examiner. This system realizes a coordinated motion according to the motion of the probe, which is hold by the robot and is moved by an examiner. We have established four kinds of situations, which are initial fixation, coordinate motions with/without contact on the body surface, and automatic chase motion of an internal organ. The system recognizes when the examiner grasps the ultrasound probe by 6-axis force sensor and touches it on body surface by processing echograms. Not only unskilled examiners but also a professional sonographer have evaluated the performance of the system after elucidating multiple parameters for compliance control and self-weight and moment compensation of the probe. As the results, this system has the potential to be able to support advanced diagnosis for conventional echography.

Probing r-Process Production of Nuclei Beyond 209Bi with Gamma Rays

DOE Office of Scientific and Technical Information (OSTI.GOV)

Qian, Y.-Z.; Vogel, P.; Wasserburg, G. J.

We estimate gamma-ray fluxes due to the decay of nuclei beyond 209Bi from a supernova or a supernova remnant assuming that the r-process occurs in supernovae. We find that a detector with a sensitivity of {approx}10-7 {gamma} cm-2 s-1 at energies from {approx}40 keV to {approx}3 MeV may detect fluxes due to the decay of 226Ra, 229Th, 241Am, 243Am, 249Cf, and 251Cf in the newly discovered supernova remnant near Vela. In addition, such a detector may detect fluxes due to the decay of 227Ac and 228Ra produced in a future supernova at a distance of {approx}1 kpc. Because nuclei withmore » mass numbers A>209 are produced solely by the r-process, such detections are the best proof for a supernova r-process site. Further, they provide the most direct information on yields of progenitor nuclei with A>209 at r-process freeze-out. Finally, detection of fluxes due to the decay of r-process nuclei over a range of masses from a supernova or a supernova remnant provides the opportunity to compare yields in a single supernova event with the solar r-process abundance pattern. (c) (c) 1999. The American Astronomical Society.« less

Future Gamma-Ray Imaging of Solar Eruptive Events

NASA Technical Reports Server (NTRS)

Shih, Albert

2012-01-01

Solar eruptive events, the combination of large solar flares and coronal mass ejections (CMEs), accelerate ions to tens of Gev and electrons to hundreds of MeV. The energy in accelerated particles can be a significant fraction (up to tens of percent) of the released energy and is roughly equipartitioned between ions and electrons. Observations of the gamma-ray signatures produced by these particles interacting with the ambient solar atmosphere probes the distribution and composition of the accelerated population, as well as the atmospheric parameters and abundances of the atmosphere, ultimately revealing information about the underlying physics. Gamma-ray imaging provided by RHESSI showed that the interacting approx.20 MeV/nucleon ions are confined to flare magnetic loops rather than precipitating from a large CME-associated shock. Furthermore, RHESSI images show a surprising, significant spatial separation between the locations where accelerated ions and electrons are interacting, thus indicating a difference in acceleration or transport processes for the two types of particles. Future gamma-ray imaging observations, with higher sensitivity and greater angular resolution, can investigate more deeply the nature of ion acceleration. The technologies being proven on the Gamma-Ray Imager/Polarimeter for Solar flares (GRIPS), a NASA balloon instrument, are possible approaches for future instrumentation. We discuss the GRIPS instrument and the future of studying this aspect of solar eruptive events.

A Robotic arm for optical and gamma radwaste inspection

NASA Astrophysics Data System (ADS)

Russo, L.; Cosentino, L.; Pappalardo, A.; Piscopo, M.; Scirè, C.; Scirè, S.; Vecchio, G.; Muscato, G.; Finocchiaro, P.

2014-12-01

We propose Radibot, a simple and cheap robotic arm for remote inspection, which interacts with the radwaste environment by means of a scintillation gamma detector and a video camera representing its light (< 1 kg) payload. It moves vertically thanks to a crane, while the other three degrees of freedom are obtained by means of revolute joints. A dedicated algorithm allows to automatically choose the best kinematics in order to reach a graphically selected position, while still allowing to fully drive the arm by means of a standard videogame joypad.

Probe Scanning Support System by a Parallel Mechanism for Robotic Echography

NASA Astrophysics Data System (ADS)

Aoki, Yusuke; Kaneko, Kenta; Oyamada, Masami; Takachi, Yuuki; Masuda, Kohji

We propose a probe scanning support system based on force/visual servoing control for robotic echography. First, we have designed and formulated its inverse kinematics the construction of mechanism. Next, we have developed a scanning method of the ultrasound probe on body surface to construct visual servo system based on acquired echogram by the standalone medical robot to move the ultrasound probe on patient abdomen in three-dimension. The visual servo system detects local change of brightness in time series echogram, which is stabilized the position of the probe by conventional force servo system in the robot, to compensate not only periodical respiration motion but also body motion. Then we integrated control method of the visual servo with the force servo as a hybrid control in both of position and force. To confirm the ability to apply for actual abdomen, we experimented the total system to follow the gallbladder as a moving target to keep its position in the echogram by minimizing variation of reaction force on abdomen. As the result, the system has a potential to be applied to automatic detection of human internal organ.

Studies of Point Defects and Defect Interactions in Metals Using Perturbed Gamma Gamma Angular Correlations

NASA Astrophysics Data System (ADS)

Shropshire, Steven Leslie

Point defects in plastically deformed Au, Pt, and Ni were studied with atomic-scale sensitivity using the perturbed gamma-gamma angular correlations (PAC) technique by monitoring formation and transformation of complexes of vacancy defects with very dilute ^{111}In/ ^{111}Cd solute probes. Three topics were investigated: (1) Production of vacancy defects during plastic deformation of Au was investigated to differentiate models of defect production. Concentrations of mono-, di-, and tri-vacancy species were measured in Au, and the ratio of mono- to di-vacancies was found to be independent of the amount of deformation. Results indicate that point defects are produced in correlated lattice locations, such as in "strings", as a consequence of dislocation interactions and not at random locations. (2) Hydrogen interactions with vacancy-solute complexes were studied in Pt. From thermal detrapping experiments, binding of hydrogen in complexes with mono-, di- and tri-vacancies was determined using a model for hydrogen diffusing in a medium with traps, with enthalpies all measured in the narrow range 0.23-0.28 eV, proving that the binding is insensitive to the precise structure of small vacancy clusters. Nuclear relaxation of the probe in a trivacancy complex in Pt was studied as a function of temperature, from which an activation energy of 0.34 eV was measured. This value is inconsistent with relaxation caused by diffusion or trapping of hydrogen, but explainable by dynamical hopping of the PAC probe atom in a cage of vacancies. (3) By observing transformations between vacancy-solute complexes induced by annihilation reactions, it was demonstrated that interstitials are produced during plastic deformation. The evolution of concentrations of the different vacancy complexes under an interstitial flux was measured and analyzed using a kinetic-rate model, from which interstitial capture cross-sections for the different vacancy complexes and the relative quantities of

Network of wireless gamma ray sensors for radiological detection and identification

NASA Astrophysics Data System (ADS)

Barzilov, A.; Womble, P.; Novikov, I.; Paschal, J.; Board, J.; Moss, K.

2007-04-01

The paper describes the design and development of a network of wireless gamma-ray sensors based on cell phone or WiFi technology. The system is intended for gamma-ray detection and automatic identification of radioactive isotopes and nuclear materials. The sensor is a gamma-ray spectrometer that uses wireless technology to distribute the results. A small-size sensor module contains a scintillation detector along with a small size data acquisition system, PDA, battery, and WiFi radio or a cell phone modem. The PDA with data acquisition and analysis software analyzes the accumulated spectrum on real-time basis and returns results to the screen reporting the isotopic composition and intensity of detected radiation source. The system has been programmed to mitigate false alarms from medical isotopes and naturally occurring radioactive materials. The decision-making software can be "trained" to indicate specific signatures of radiation sources like special nuclear materials. The sensor is supplied with GPS tracker coupling radiological information with geographical coordinates. The sensor is designed for easy use and rapid deployment in common wireless networks.

Sentinel node detection in early breast cancer with intraoperative portable gamma camera: UK experience.

PubMed

Ghosh, Debashis; Michalopoulos, Nikolaos V; Davidson, Timothy; Wickham, Fred; Williams, Norman R; Keshtgar, Mohammed R

2017-04-01

Access to nuclear medicine department for sentinel node imaging remains an issue in number of hospitals in the UK and many parts of the world. Sentinella ® is a portable imaging camera used intra-operatively to produce real time visual localisation of sentinel lymph nodes. Sentinella ® was tested in a controlled laboratory environment at our centre and we report our experience on the first use of this technology from UK. Moreover, preoperative scintigrams of the axilla were obtained in 144 patients undergoing sentinel node biopsy using conventional gamma camera. Sentinella ® scans were done intra-operatively to correlate with the pre-operative scintigram and to determine presence of any residual hot node after the axilla was deemed to be clear based on the silence of the hand held gamma probe. Sentinella ® detected significantly more nodes compared with CGC (p < 0.0001). Sentinella ® picked up extra nodes in 5/144 cases after the axilla was found silent using hand held gamma probe. In 2/144 cases, extra nodes detected by Sentinella ® confirmed presence of tumour cells that led to a complete axillary clearance. Sentinella ® is a reliable technique for intra-operative localisation of radioactive nodes. It provides increased nodal visualisation rates compared to static scintigram imaging and proves to be an important tool for harvesting all hot sentinel nodes. This portable gamma camera can definitely replace the use of conventional lymphoscintigrams saving time and money both for patients and the health system. Copyright © 2016 Elsevier Ltd. All rights reserved.

Auto-tuning system for NMR probe with LabView

NASA Astrophysics Data System (ADS)

Quen, Carmen; Mateo, Olivia; Bernal, Oscar

2013-03-01

Typical manual NMR-tuning method is not suitable for broadband spectra spanning several megahertz linewidths. Among the main problems encountered during manual tuning are pulse-power reproducibility, baselines, and transmission line reflections, to name a few. We present a design of an auto-tuning system using graphic programming language, LabVIEW, to minimize these problems. The program is designed to analyze the detected power signal of an antenna near the NMR probe and use this analysis to automatically tune the sample coil to match the impedance of the spectrometer (50 Ω). The tuning capacitors of the probe are controlled by a stepper motor through a LabVIEW/computer interface. Our program calculates the area of the power signal as an indicator to control the motor so disconnecting the coil to tune it through a network analyzer is unnecessary. Work supported by NSF-DMR 1105380

Optical Sensors for Monitoring Gamma and Neutron Radiation

NASA Technical Reports Server (NTRS)

Boyd, Clark D.

2011-01-01

For safety and efficiency, nuclear reactors must be carefully monitored to provide feedback that enables the fission rate to be held at a constant target level via adjustments in the position of neutron-absorbing rods and moderating coolant flow rates. For automated reactor control, the monitoring system should provide calibrated analog or digital output. The sensors must survive and produce reliable output with minimal drift for at least one to two years, for replacement only during refueling. Small sensor size is preferred to enable more sensors to be placed in the core for more detailed characterization of the local fission rate and fuel consumption, since local deviations from the norm tend to amplify themselves. Currently, reactors are monitored by local power range meters (LPRMs) based on the neutron flux or gamma thermometers based on the gamma flux. LPRMs tend to be bulky, while gamma thermometers are subject to unwanted drift. Both electronic reactor sensors are plagued by electrical noise induced by ionizing radiation near the reactor core. A fiber optic sensor system was developed that is capable of tracking thermal neutron fluence and gamma flux in order to monitor nuclear reactor fission rates. The system provides near-real-time feedback from small- profile probes that are not sensitive to electromagnetic noise. The key novel feature is the practical design of fiber optic radiation sensors. The use of an actinoid element to monitor neutron flux in fiber optic EFPI (extrinsic Fabry-Perot interferometric) sensors is a new use of material. The materials and structure used in the sensor construction can be adjusted to result in a sensor that is sensitive to just thermal, gamma, or neutron stimulus, or any combination of the three. The tested design showed low sensitivity to thermal and gamma stimuli and high sensitivity to neutrons, with a fast response time.

Neutron Capture Gamma-Ray Libraries for Nuclear Applications

NASA Astrophysics Data System (ADS)

Sleaford, B. W.; Firestone, R. B.; Summers, N.; Escher, J.; Hurst, A.; Krticka, M.; Basunia, S.; Molnar, G.; Belgya, T.; Revay, Z.; Choi, H. D.

2011-06-01

The neutron capture reaction is useful in identifying and analyzing the gamma-ray spectrum from an unknown assembly as it gives unambiguous information on its composition. This can be done passively or actively where an external neutron source is used to probe an unknown assembly. There are known capture gamma-ray data gaps in the ENDF libraries used by transport codes for various nuclear applications. The Evaluated Gamma-ray Activation file (EGAF) is a new thermal neutron capture database of discrete line spectra and cross sections for over 260 isotopes that was developed as part of an IAEA Coordinated Research Project. EGAF is being used to improve the capture gamma production in ENDF libraries. For medium to heavy nuclei the quasi continuum contribution to the gamma cascades is not experimentally resolved. The continuum contains up to 90% of all the decay energy and is modeled here with the statistical nuclear structure code DICEBOX. This code also provides a consistency check of the level scheme nuclear structure evaluation. The calculated continuum is of sufficient accuracy to include in the ENDF libraries. This analysis also determines new total thermal capture cross sections and provides an improved RIPL database. For higher energy neutron capture there is less experimental data available making benchmarking of the modeling codes more difficult. We are investigating the capture spectra from higher energy neutrons experimentally using surrogate reactions and modeling this with Hauser-Feshbach codes. This can then be used to benchmark CASINO, a version of DICEBOX modified for neutron capture at higher energy. This can be used to simulate spectra from neutron capture at incident neutron energies up to 20 MeV to improve the gamma-ray spectrum in neutron data libraries used for transport modeling of unknown assemblies.

Anticonvulsant properties of alpha, gamma, and alpha, gamma-substituted gamma-butyrolactones.

PubMed

Klunk, W E; Covey, D F; Ferrendelli, J A

1982-09-01

Derivatives of gamma-butyrolactone (GBL) substituted on the alpha- and/or gamma-positions were synthesized and tested for their effects on behavior in mice, on the electroencephalographs and blood pressure of paralyzed-ventilated guinea pigs, and on electrical activity of incubated hippocampal slices. Several compounds, including alpha-ethyl-alpha-methyl GBL (alpha-EMGBL), alpha, alpha-dimethyl GBL, alpha, gamma-diethyl-alpha, gamma-dimethyl GBL, and gamma-ethyl-gamma-methyl GBL, prevented seizures induced by pentylenetetrazol, beta-ethyl-beta-methyl-gamma-butyrolactone (beta-EMGBL), picrotoxin, or all three compounds in mice and guinea pigs but had no effect on seizures induced by maximal electroshock or bicuculline. Neither gamma-hydroxybutyrate (GHB) nor alpha-isopropylidine GBL had any anticonvulsant activity. The anticonvulsant alpha-substituted compounds had a potent hypotensive effect and antagonized the hypertensive effect of beta-EMGBL, alpha-EMGBL was tested in incubated hippocampal slices and was found to depress basal activity and antagonize excitation induced by beta-EMGBL. These results demonstrate that alpha-alkyl-substituted GBL and, to a lesser extent, gamma-substituted derivatives are anticonvulsant agents and that their effects are strikingly different from those of GHB or beta-alkyl-substituted GBLs, which are epileptogenic. Possibly beta- and alpha-substituted GBLs act at the same site as agonists and antagonists, respectively.

Integral-moment analysis of the BATSE gamma-ray burst intensity distribution

NASA Technical Reports Server (NTRS)

Horack, John M.; Emslie, A. Gordon

1994-01-01

We have applied the technique of integral-moment analysis to the intensity distribution of the first 260 gamma-ray bursts observed by the Burst and Transient Source Experiment (BATSE) on the Compton Gamma Ray Observatory. This technique provides direct measurement of properties such as the mean, variance, and skewness of the convolved luminosity-number density distribution, as well as associated uncertainties. Using this method, one obtains insight into the nature of the source distributions unavailable through computation of traditional single parameters such as V/V(sub max)). If the luminosity function of the gamma-ray bursts is strongly peaked, giving bursts only a narrow range of luminosities, these results are then direct probes of the radial distribution of sources, regardless of whether the bursts are a local phenomenon, are distributed in a galactic halo, or are at cosmological distances. Accordingly, an integral-moment analysis of the intensity distribution of the gamma-ray bursts provides for the most complete analytic description of the source distribution available from the data, and offers the most comprehensive test of the compatibility of a given hypothesized distribution with observation.

TEMPORAL CORRELATIONS BETWEEN OPTICAL AND GAMMA-RAY ACTIVITY IN BLAZARS

DOE PAGES

Cohen, Daniel P.; Romani, Roger W.; Filippenko, Alexei V.; ...

2014-12-08

For this research, we have been using the 0.76 m Katzman Automatic Imaging Telescope (KAIT) at Lick Observatory to optically monitor a sample of 157 blazars that are bright in gamma-rays being detected with high significance (≥10σ) in one year by the Large Area Telescope (LAT) on the Fermi Gamma-ray Space Telescope. We attempt to observe each source on a three-day cadence with KAIT, subject to weather and seasonal visibility. The gamma-ray coverage is essentially continuous. KAIT observations extend over much of the five-year Fermi mission for several objects, and most have >100 optical measurements spanning the last three years.more » These blazars (flat-spectrum radio quasars and BL Lac objects) exhibit a wide range of flaring behavior. Using the discrete correlation function (DCF), here we search for temporal relationships between optical and gamma-ray light curves in the 40 brightest sources in hopes of placing constraints on blazar acceleration and emission zones. We find strong optical-gamma-ray correlation in many of these sources at time delays of ~1 to ~10 days, ranging between –40 and +30 days. A stacked average DCF of the 40 sources verifies this correlation trend, with a peak above 99% significance indicating a characteristic time delay consistent with 0 days. These findings strongly support the widely accepted leptonic models of blazar emission. However, we also find examples of apparently uncorrelated flares (optical flares with no gamma-ray counterpart and gamma-ray flares with no optical counterpart) that challenge simple, one-zone models of blazar emission. Moreover, we find that flat-spectrum radio quasars tend to have gamma-rays leading the optical, while intermediate- and high-synchrotron peak blazars with the most significant peaks have smaller lags/leads. In conclusion, it is clear that long-term monitoring at high cadence is necessary to reveal the underlying physical correlation.« less

Chemical Probes of Rapid Estrogen Signaling in Breast Cancer Treatment and Chemoprevention

DTIC Science & Technology

2006-04-01

conjugated to cell-impermeable polyacrylate polymers that should allow for selective targeting of membrane-initiated responses of estrogen receptor. It...dilutions of the different compounds were prepared in ES2 screening buffer (100 mM potassium phosphate, pH7.4, 100 µg/ml bovine gamma globulin) and 50 µl...W81XWH-04-1-0447 TITLE: Chemical Probes of Rapid Estrogen Signaling in Breast Cancer Treatment and Chemoprevention PRINCIPAL

Probing the Higgs Couplings to Photons in h→4l at the LHC

DOE PAGES

Chen, Yi; Harnik, Roni; Vega-Morales, Roberto

2014-11-01

We explore the sensitivity of the Higgs decay to four leptons, the so-called golden channel, to higher dimensional loop-induced couplings of the Higgs boson tomore » $ZZ$, $$Z\\gamma$$, and $$\\gamma\\gamma$$, allowing for general CP mixtures. The larger standard model tree level coupling $$hZ^\\mu Z_\\mu$$ is the dominant "background" for the loop induced couplings. However this large background interferes with the smaller loop induced couplings, enhancing the sensitivity. We perform a maximum likelihood analysis based on analytic expressions of the fully differential decay width for $$h\\to 4\\ell$$ ($$4\\ell \\equiv 2e2\\mu, 4e, 4\\mu$$) including all interference effects. We find that the spectral shapes induced by Higgs couplings to photons are particularly different than the $$hZ^\\mu Z_\\mu$$ background leading to enhanced sensitivity to these couplings. We show that even if the $$h\\to\\gamma\\gamma$$ and $$h\\to 4\\ell$$ rates agree with that predicted by the Standard Model, the golden channel has the potential to probe both the CP nature as well as the overall sign of the Higgs coupling to photons well before the end of high-luminosity LHC running ($$\\sim$$3 ab$$^{-1}$$).« less

Optogenetically induced spatiotemporal gamma oscillations and neuronal spiking activity in primate motor cortex.

PubMed

Lu, Yao; Truccolo, Wilson; Wagner, Fabien B; Vargas-Irwin, Carlos E; Ozden, Ilker; Zimmermann, Jonas B; May, Travis; Agha, Naubahar S; Wang, Jing; Nurmikko, Arto V

2015-06-01

Transient gamma-band (40-80 Hz) spatiotemporal patterns are hypothesized to play important roles in cortical function. Here we report the direct observation of gamma oscillations as spatiotemporal waves induced by targeted optogenetic stimulation, recorded by intracortical multichannel extracellular techniques in macaque monkeys during their awake resting states. Microelectrode arrays integrating an optical fiber at their center were chronically implanted in primary motor (M1) and ventral premotor (PMv) cortices of two subjects. Targeted brain tissue was transduced with the red-shifted opsin C1V1(T/T). Constant (1-s square pulses) and ramp stimulation induced narrowband gamma oscillations during awake resting states. Recordings across 95 microelectrodes (4 × 4-mm array) enabled us to track the transient gamma spatiotemporal patterns manifested, e.g., as concentric expanding and spiral waves. Gamma oscillations were induced well beyond the light stimulation volume, via network interactions at distal electrode sites, depending on optical power. Despite stimulation-related modulation in spiking rates, neuronal spiking remained highly asynchronous during induced gamma oscillations. In one subject we examined stimulation effects during preparation and execution of a motor task and observed that movement execution largely attenuated optically induced gamma oscillations. Our findings demonstrate that, beyond previously reported induced gamma activity under periodic drive, a prolonged constant stimulus above a certain threshold may carry primate motor cortex network dynamics into gamma oscillations, likely via a Hopf bifurcation. More broadly, the experimental capability in combining microelectrode array recordings and optogenetic stimulation provides an important approach for probing spatiotemporal dynamics in primate cortical networks during various physiological and behavioral conditions.

PROcess Based Diagnostics PROBE

NASA Technical Reports Server (NTRS)

Clune, T.; Schmidt, G.; Kuo, K.; Bauer, M.; Oloso, H.

2013-01-01

Many of the aspects of the climate system that are of the greatest interest (e.g., the sensitivity of the system to external forcings) are emergent properties that arise via the complex interplay between disparate processes. This is also true for climate models most diagnostics are not a function of an isolated portion of source code, but rather are affected by multiple components and procedures. Thus any model-observation mismatch is hard to attribute to any specific piece of code or imperfection in a specific model assumption. An alternative approach is to identify diagnostics that are more closely tied to specific processes -- implying that if a mismatch is found, it should be much easier to identify and address specific algorithmic choices that will improve the simulation. However, this approach requires looking at model output and observational data in a more sophisticated way than the more traditional production of monthly or annual mean quantities. The data must instead be filtered in time and space for examples of the specific process being targeted.We are developing a data analysis environment called PROcess-Based Explorer (PROBE) that seeks to enable efficient and systematic computation of process-based diagnostics on very large sets of data. In this environment, investigators can define arbitrarily complex filters and then seamlessly perform computations in parallel on the filtered output from their model. The same analysis can be performed on additional related data sets (e.g., reanalyses) thereby enabling routine comparisons between model and observational data. PROBE also incorporates workflow technology to automatically update computed diagnostics for subsequent executions of a model. In this presentation, we will discuss the design and current status of PROBE as well as share results from some preliminary use cases.

Flavored Dark Matter and the Galactic Center Gamma-Ray Excess

DOE Office of Scientific and Technical Information (OSTI.GOV)

Agrawal, Prateek; Batell, Brian; Hooper, Dan

Thermal relic dark matter particles with a mass of 31-40 GeV and that dominantly annihilate to bottom quarks have been shown to provide an excellent description of the excess gamma rays observed from the center of the Milky Way. Flavored dark matter provides a well-motivated framework in which the dark matter can dominantly couple to bottom quarks in a flavor-safe manner. We propose a phenomenologically viable model of bottom flavored dark matter that can account for the spectral shape and normalization of the gamma-ray excess while naturally suppressing the elastic scattering cross sections probed by direct detection experiments. This modelmore » will be definitively tested with increased exposure at LUX and with data from the upcoming high-energy run of the Large Hadron Collider (LHC).« less

Detectors for the gamma-ray resonant absorption (GRA) method of explosives detection in cargo: a comparative study

NASA Astrophysics Data System (ADS)

Vartsky, David; Goldberg, Mark B.; Engler, Gideon; Shor, Asher; Goldschmidt, Aharon; Feldman, Gennady; Bar, Doron; Orion, Itzhak; Wielopolski, Lucian

2004-01-01

Gamma-Ray Resonant Absorption (GRA) is an automatic-decision radiographic screening technique that combines high radiation penetration with very good sensitivity and specificity to nitrogenous explosives. The method is particularly well-suited to inspection of large, massive objects (since the resonant γ-ray probe is at 9.17 MeV) such as aviation and marine containers, heavy vehicles and railroad cars. Two kinds of γ-ray detectors have been employed to date in GRA systems: 1) Resonant-response nitrogen-rich liquid scintillators and 2) BGO detectors. This paper analyses and compares the response of these detector-types to the resonant radiation, in terms of single-pixel figures of merit. The latter are sensitive not only to detector response, but also to accelerator-beam quality, via the properties of the nuclear reaction that produces the resonant-γ-rays. Generally, resonant detectors give rise to much higher nitrogen-contrast sensitivity in the radiographic image than their non-resonant detector counterparts and furthermore, do not require proton beams of high energy-resolution. By comparison, the non-resonant detectors have higher γ-detection efficiency, but their contrast sensitivity is very sensitive to the quality of the accelerator beam. Implications of these detector/accelerator characteristics for eventual GRA field systems are discussed.

Gamma Ray Bursts in the Swift-Fermi Era

NASA Technical Reports Server (NTRS)

Gehrels, Neil; Razzaque, Soebur

2013-01-01

Gamma-ray bursts (GRBs) are among the most violent occurrences in the universe. They are powerful explosions, visible to high redshift, and thought to be the signature of black hole birth. They are highly luminous events and provide excellent probes of the distant universe. GRB research has greatly advanced over the past 10 years with the results from Swift, Fermi and an active follow-up community. In this review we survey the interplay between these recent observations and the theoretical models of the prompt GRB emission and the subsequent afterglows.

Automatic digital image analysis for identification of mitotic cells in synchronous mammalian cell cultures.

PubMed

Eccles, B A; Klevecz, R R

1986-06-01

Mitotic frequency in a synchronous culture of mammalian cells was determined fully automatically and in real time using low-intensity phase-contrast microscopy and a newvicon video camera connected to an EyeCom III image processor. Image samples, at a frequency of one per minute for 50 hours, were analyzed by first extracting the high-frequency picture components, then thresholding and probing for annular objects indicative of putative mitotic cells. Both the extraction of high-frequency components and the recognition of rings of varying radii and discontinuities employed novel algorithms. Spatial and temporal relationships between annuli were examined to discern the occurrences of mitoses, and such events were recorded in a computer data file. At present, the automatic analysis is suited for random cell proliferation rate measurements or cell cycle studies. The automatic identification of mitotic cells as described here provides a measure of the average proliferative activity of the cell population as a whole and eliminates more than eight hours of manual review per time-lapse video recording.

The agile alert system for gamma-ray transients

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bulgarelli, A.; Trifoglio, M.; Gianotti, F.

2014-01-20

In recent years, a new generation of space missions has offered great opportunities for discovery in high-energy astrophysics. In this article we focus on the scientific operations of the Gamma-Ray Imaging Detector (GRID) on board the AGILE space mission. AGILE-GRID, sensitive in the energy range of 30 MeV-30 GeV, has detected many γ-ray transients of both galactic and extragalactic origin. This work presents the AGILE innovative approach to fast γ-ray transient detection, which is a challenging task and a crucial part of the AGILE scientific program. The goals are to describe (1) the AGILE Gamma-Ray Alert System, (2) a newmore » algorithm for blind search identification of transients within a short processing time, (3) the AGILE procedure for γ-ray transient alert management, and (4) the likelihood of ratio tests that are necessary to evaluate the post-trial statistical significance of the results. Special algorithms and an optimized sequence of tasks are necessary to reach our goal. Data are automatically analyzed at every orbital downlink by an alert pipeline operating on different timescales. As proper flux thresholds are exceeded, alerts are automatically generated and sent as SMS messages to cellular telephones, via e-mail, and via push notifications from an application for smartphones and tablets. These alerts are crosschecked with the results of two pipelines, and a manual analysis is performed. Being a small scientific-class mission, AGILE is characterized by optimization of both scientific analysis and ground-segment resources. The system is capable of generating alerts within two to three hours of a data downlink, an unprecedented reaction time in γ-ray astrophysics.« less

The AGILE Alert System for Gamma-Ray Transients

NASA Astrophysics Data System (ADS)

Bulgarelli, A.; Trifoglio, M.; Gianotti, F.; Tavani, M.; Parmiggiani, N.; Fioretti, V.; Chen, A. W.; Vercellone, S.; Pittori, C.; Verrecchia, F.; Lucarelli, F.; Santolamazza, P.; Fanari, G.; Giommi, P.; Beneventano, D.; Argan, A.; Trois, A.; Scalise, E.; Longo, F.; Pellizzoni, A.; Pucella, G.; Colafrancesco, S.; Conforti, V.; Tempesta, P.; Cerone, M.; Sabatini, P.; Annoni, G.; Valentini, G.; Salotti, L.

2014-01-01

In recent years, a new generation of space missions has offered great opportunities for discovery in high-energy astrophysics. In this article we focus on the scientific operations of the Gamma-Ray Imaging Detector (GRID) on board the AGILE space mission. AGILE-GRID, sensitive in the energy range of 30 MeV-30 GeV, has detected many γ-ray transients of both galactic and extragalactic origin. This work presents the AGILE innovative approach to fast γ-ray transient detection, which is a challenging task and a crucial part of the AGILE scientific program. The goals are to describe (1) the AGILE Gamma-Ray Alert System, (2) a new algorithm for blind search identification of transients within a short processing time, (3) the AGILE procedure for γ-ray transient alert management, and (4) the likelihood of ratio tests that are necessary to evaluate the post-trial statistical significance of the results. Special algorithms and an optimized sequence of tasks are necessary to reach our goal. Data are automatically analyzed at every orbital downlink by an alert pipeline operating on different timescales. As proper flux thresholds are exceeded, alerts are automatically generated and sent as SMS messages to cellular telephones, via e-mail, and via push notifications from an application for smartphones and tablets. These alerts are crosschecked with the results of two pipelines, and a manual analysis is performed. Being a small scientific-class mission, AGILE is characterized by optimization of both scientific analysis and ground-segment resources. The system is capable of generating alerts within two to three hours of a data downlink, an unprecedented reaction time in γ-ray astrophysics.

Wide-Field Imaging Telescope-0 (WIT0) with automatic observing system

NASA Astrophysics Data System (ADS)

Ji, Tae-Geun; Byeon, Seoyeon; Lee, Hye-In; Park, Woojin; Lee, Sang-Yun; Hwang, Sungyong; Choi, Changsu; Gibson, Coyne Andrew; Kuehne, John W.; Prochaska, Travis; Marshall, Jennifer L.; Im, Myungshin; Pak, Soojong

2018-01-01

We introduce Wide-Field Imaging Telescope-0 (WIT0), with an automatic observing system. It is developed for monitoring the variabilities of many sources at a time, e.g. young stellar objects and active galactic nuclei. It can also find the locations of transient sources such as a supernova or gamma-ray bursts. In 2017 February, we installed the wide-field 10-inch telescope (Takahashi CCA-250) as a piggyback system on the 30-inch telescope at the McDonald Observatory in Texas, US. The 10-inch telescope has a 2.35 × 2.35 deg field-of-view with a 4k × 4k CCD Camera (FLI ML16803). To improve the observational efficiency of the system, we developed a new automatic observing software, KAOS30 (KHU Automatic Observing Software for McDonald 30-inch telescope), which was developed by Visual C++ on the basis of a windows operating system. The software consists of four control packages: the Telescope Control Package (TCP), the Data Acquisition Package (DAP), the Auto Focus Package (AFP), and the Script Mode Package (SMP). Since it also supports the instruments that are using the ASCOM driver, the additional hardware installations become quite simplified. We commissioned KAOS30 in 2017 August and are in the process of testing. Based on the WIT0 experiences, we will extend KAOS30 to control multiple telescopes in future projects.

beta- and gamma-Comparative dose estimates on Enewetak Atoll.

PubMed

Crase, K W; Gudiksen, P H; Robison, W L

1982-05-01

Enewetak Atoll is one of the Pacific atolls used for atmospheric testing of U.S. nuclear weapons. Beta dose and gamma-ray exposure measurements were made on two islands of the Enewetak Atoll during July-August 1976 to determine the beta and low energy gamma-contribution to the total external radiation doses to the returning Marshallese. Measurements were made at numerous locations with thermoluminescent dosimeters (TLD), pressurized ionization chambers, portable NaI detectors, and thin-window pancake GM probes. Results of the TLD measurements with and without a beta-attenuator indicate that approx. 29% of the total dose rate at 1 m in air is due to beta- or low energy gamma-contribution. The contribution at any particular site, however, is somewhat dependent on ground cover, since a minimal amount of vegetation will reduce it significantly from that over bare soil, but thick stands of vegetation have little effect on any further reductions. Integral 30-yr external shallow dose estimates for future inhabitants were made and compared with external dose estimates of a previous large scale radiological survey (En73). Integral 30-yr shallow external dose estimates are 25-50% higher than whole body estimates. Due to the low penetrating ability of the beta's or low energy gamma's, however, several remedial actions can be taken to reduce the shallow dose contribution to the total external dose.

Focused attention, open monitoring and automatic self-transcending: Categories to organize meditations from Vedic, Buddhist and Chinese traditions.

PubMed

Travis, Fred; Shear, Jonathan

2010-12-01

This paper proposes a third meditation-category--automatic self-transcending--to extend the dichotomy of focused attention and open monitoring proposed by Lutz. Automatic self-transcending includes techniques designed to transcend their own activity. This contrasts with focused attention, which keeps attention focused on an object; and open monitoring, which keeps attention involved in the monitoring process. Each category was assigned EEG bands, based on reported brain patterns during mental tasks, and meditations were categorized based on their reported EEG. Focused attention, characterized by beta/gamma activity, included meditations from Tibetan Buddhist, Buddhist, and Chinese traditions. Open monitoring, characterized by theta activity, included meditations from Buddhist, Chinese, and Vedic traditions. Automatic self-transcending, characterized by alpha1 activity, included meditations from Vedic and Chinese traditions. Between categories, the included meditations differed in focus, subject/object relation, and procedures. These findings shed light on the common mistake of averaging meditations together to determine mechanisms or clinical effects. Copyright © 2010 Elsevier Inc. All rights reserved.

Automatic Adjustments of a Trans-oesophageal Ultrasound Robot for Monitoring Intra-operative Catheters

NASA Astrophysics Data System (ADS)

Wang, Shuangyi; Housden, James; Singh, Davinder; Rhode, Kawal

2017-12-01

3D trans-oesophageal echocardiography (TOE) has become a powerful tool for monitoring intra-operative catheters used during cardiac procedures in recent years. However, the control of the TOE probe remains as a manual task and therefore the operator has to hold the probe for a long period of time and sometimes in a radiation environment. To solve this problem, an add-on robotic system has been developed for holding and manipulating a commercial TOE probe. This paper focuses on the application of making automatic adjustments to the probe pose in order to accurately monitor the moving catheters. The positioning strategy is divided into an initialization step based on a pre-planning method and a localized adjustments step based on the robotic differential kinematics and related image servoing techniques. Both steps are described in the paper along with simulation experiments performed to validate the concept. The results indicate an error less than 0.5 mm for the initialization step and an error less than 2 mm for the localized adjustments step. Compared to the much bigger live 3D image volume, it is concluded that the methods are promising. Future work will focus on evaluating the method in the real TOE scanning scenario.

DISCOVERY OF A TRANSIENT GAMMA-RAY COUNTERPART TO FRB 131104

DOE Office of Scientific and Technical Information (OSTI.GOV)

DeLaunay, J. J.; Murase, K.; Mészáros, P.

We report our discovery in Swift satellite data of a transient gamma-ray counterpart (3.2 σ confidence) to the fast radio burst (FRB) FRB 131104, the first such counterpart to any FRB. The transient has a duration T {sub 90} ≳ 100 s and a fluence S{sub γ} ≈ 4 × 10{sup −6} erg cm{sup −2}, increasing the energy budget for this event by more than a billion times; at the nominal z ≈ 0.55 redshift implied by its dispersion measure, the burst’s gamma-ray energy output is E{sub γ} ≈ 5 × 10{sup 51} erg. The observed radio to gamma-ray fluencemore » ratio for FRB 131104 is consistent with a lower limit we derive from Swift observations of another FRB, which is not detected in gamma-rays, and with an upper limit previously derived for the brightest gamma-ray flare from SGR 1806−20, which was not detected in the radio. X-ray, ultraviolet, and optical observations beginning two days after the FRB do not reveal any associated afterglow, supernova, or transient; Swift observations exclude association with the brightest 65% of Swift gamma-ray burst (GRB) X-ray afterglows, while leaving the possibility of an associated supernova at much more than 10% the FRB’s nominal distance, D ≳ 320 Mpc, largely unconstrained. Transient high-luminosity gamma-ray emission arises most naturally in a relativistic outflow or shock breakout, such as, for example, from magnetar flares, GRBs, relativistic supernovae, and some types of galactic nuclear activity. Our discovery thus bolsters the case for an extragalactic origin for some FRBs and suggests that future rapid-response observations might identify long-lived counterparts, resolving the nature of these mysterious phenomena and realizing their promise as probes of cosmology and fundamental physics.« less

Feasibility study of a low-energy gamma ray system for measuring quantity and flow rate of slush hydrogen

NASA Technical Reports Server (NTRS)

Singh, Jag J.; Shen, Chih-Ping; Sprinkle, Danny R.

1992-01-01

As part of a study to demonstrate the suitability of an X-ray or gamma ray probe for monitoring the quality and flow rate of slush hydrogen, mass attenuation coefficients for Cd-109 X- and gamma radiation in five chemical compounds were measured. The Ag-109 K rays were used for water and acetic acid, whereas E3 transition from the first excited state at 87.7 keV in Ag-109 provided the probe radiation for bromobenzene, alpha (exp 2) chloroisodurene, and cetyl bromide. Measurements were made for a single phase (gas, liquid, solid) as well as mixed phases (liquid plus solid) in all cases. It was shown that the mass attenuation coefficient for the selected radiations is independent of the phase of the test fluids or phase ratios in the case of mixed phase fluids. Described here are the procedure and the results for the five fluid systems investigated.

Probing Neutron Star Evolution with Gamma Rays

NASA Astrophysics Data System (ADS)

Wijers, Ralph A. M. J.

1996-02-01

The research sponsored by this grant was conducted in two fields of high-energy astrophysics: gamma-ray bursts and evolution of neutron stars. It is unknown at this time whether they are related. The work performed in each area is discussed followed by a full list of publications supported by the grant. My research (with E. Fenimore, L. Lubin, B. Paczyiiski, and A. Ulmer) has focussed on devising tests that could distinguish between BATSE and galactic-halo distance scales using the available data. In the first instance, the issue was whether the early BATSE peak flux distribution could be used to extract more than just a slope of the log N(greater than P) distribution, and whether it joined smoothly to the steeper peak flux distribution of bright bursts. To this end, we analysed the peak flux distribution for the presence of a change in slope. This was done both by fitting models with a core radius to see whether a significant value for it could be found, and by developing a completely model-independent test to search for slope changes in arbitrary distributions that are nearly power laws. A slope change was marginally detected in the first-year BATSE data. Good progress has been made in understanding the evolution of neutron stars and their magnetic fields. Having shown in earlier work that magnetic fields in some neutron stars, particularly Her X-1, do not decay spontaneously on million-year time scales, we set out to check whether such spontaneous decay was needed in isolated radio pulsars, as claimed by many. We found that it is not; rather long decay times or no decay are preferred. Since there are neutron stars with low magnetic fields, one must conclude that there is something in their past that distinguishes them from most pulsars. These so-called recycled pulsars are in binaries much more often than normal pulsars. My research concentrates on the class of scenarios in which the recycled pulsars are initially the same as ordinary high-field radio pulsars

Restriction fragment length polymorphisms for growth hormone, prolactin, osteonectin, alpha crystallin, gamma crystallin, fibronectin and 21-steroid hydroxylase in cattle.

PubMed

Theilmann, J L; Skow, L C; Baker, J F; Womack, J E

1989-01-01

Genomic DNAs from animals representing six breeds of cattle (Angus, Brahman, Hereford, Holstein, Jersey and Texas Longhorn) were screened with cloned gene probes in a search for restriction fragment length polymorphisms (RFLPs). Eleven RFLPs were identified using seven different probes: growth hormone, prolactin, osteonectin, alpha A-crystallin, gamma crystallin, fibronectin and 21-steroid hydroxylase. The frequencies of the alleles identified by each probe were calculated and compared in a limited sampling of the six bovine breeds. These polymorphisms greatly enhance the pool of immunogenetic, biochemical and molecular markers available in cattle for linkage analysis, testing of parentage, and distinction of breeds.

Optogenetically induced spatiotemporal gamma oscillations and neuronal spiking activity in primate motor cortex

PubMed Central

Lu, Yao; Truccolo, Wilson; Wagner, Fabien B.; Vargas-Irwin, Carlos E.; Ozden, Ilker; Zimmermann, Jonas B.; May, Travis; Agha, Naubahar S.; Wang, Jing

2015-01-01

Transient gamma-band (40–80 Hz) spatiotemporal patterns are hypothesized to play important roles in cortical function. Here we report the direct observation of gamma oscillations as spatiotemporal waves induced by targeted optogenetic stimulation, recorded by intracortical multichannel extracellular techniques in macaque monkeys during their awake resting states. Microelectrode arrays integrating an optical fiber at their center were chronically implanted in primary motor (M1) and ventral premotor (PMv) cortices of two subjects. Targeted brain tissue was transduced with the red-shifted opsin C1V1(T/T). Constant (1-s square pulses) and ramp stimulation induced narrowband gamma oscillations during awake resting states. Recordings across 95 microelectrodes (4 × 4-mm array) enabled us to track the transient gamma spatiotemporal patterns manifested, e.g., as concentric expanding and spiral waves. Gamma oscillations were induced well beyond the light stimulation volume, via network interactions at distal electrode sites, depending on optical power. Despite stimulation-related modulation in spiking rates, neuronal spiking remained highly asynchronous during induced gamma oscillations. In one subject we examined stimulation effects during preparation and execution of a motor task and observed that movement execution largely attenuated optically induced gamma oscillations. Our findings demonstrate that, beyond previously reported induced gamma activity under periodic drive, a prolonged constant stimulus above a certain threshold may carry primate motor cortex network dynamics into gamma oscillations, likely via a Hopf bifurcation. More broadly, the experimental capability in combining microelectrode array recordings and optogenetic stimulation provides an important approach for probing spatiotemporal dynamics in primate cortical networks during various physiological and behavioral conditions. PMID:25761956

An automatic gore panel mapping system

NASA Technical Reports Server (NTRS)

Shiver, John D.; Phelps, Norman N.

1990-01-01

The Automatic Gore Mapping System is being developed to reduce the time and labor costs associated with manufacturing the External Tank. The present chem-milling processes and procedures are discussed. The down loading of the simulation of the system has to be performed to verify that the simulation package will translate the simulation code into robot code. Also a simulation of this system has to be programmed for a gantry robot instead of the articulating robot that is presently in the system. It was discovered using the simulation package that the articulation robot cannot reach all the point on some of the panels, therefore when the system is ready for production, a gantry robot will be used. Also a hydrosensor system is being developed to replace the point-to-point contact probe. The hydrosensor will allow the robot to perform a non-contact continuous scan of the panel. It will also provide a faster scan of the panel because it will eliminate the in-and-out movement required for the present end effector. The system software is currently being modified so that the hydrosensor will work with the system. The hydrosensor consists of a Krautkramer-Branson transducer encased in a plexiglass nozzle. The water stream pumped through the nozzle is the couplant for the probe. Also, software is being written so that the robot will have the ability to draw the contour lines on the panel displaying the out-of-tolerance regions. Presently the contour lines can only be displayed on the computer screens. Research is also being performed on improving and automating the method of scribing the panels. Presently the panels are manually scribed with a sharp knife. The use of a low power laser or water jet is being studied as a method of scribing the panels. The contour drawing pen will be replaced with scribing tool and the robot will then move along the contour lines. With these developments the Automatic Gore Mapping Systems will provide a reduction in time and labor costs

Gamma-irradiation of malic acid in aqueous solutions. [prebiotic significance

NASA Technical Reports Server (NTRS)

Negron-Mendoza, A.; Graff, R. L.; Ponnamperuma, C.

1980-01-01

The gamma-irradiation of malic acid in aqueous solutions was studied under initially oxygenated and oxygen-free conditions in an attempt to determine the possible interconversion of malic acid into other carboxylic acids, specifically those associated with Krebs cycle. The effect of dose on product formation of the system was investigated. Gas-liquid chromatography combined with mass spectrometry was used as the principal means of identification of the nonvolatile products. Thin layer chromatography and direct probe mass spectroscopy were also employed. The findings show that a variety of carboxylic acids are formed, with malonic and succinic acids in greatest abundance. These products have all been identified as being formed in the gamma-irradiation of acetic acid, suggesting a common intermediary. Since these molecules fit into a metabolic cycle, it is strongly suggestive that prebiotic pathways provided the basis for biological systems.

Investigation of redshift- and duration-dependent clustering of gamma-ray bursts

DOE PAGES

Ukwatta, T. N.; Woźniak, P. R.

2015-11-05

Gamma-ray bursts (GRBs) are detectable out to very large distances and as such are potentially powerful cosmological probes. Historically, the angular distribution of GRBs provided important information about their origin and physical properties. As a general population, GRBs are distributed isotropically across the sky. However, there are published reports that once binned by duration or redshift, GRBs display significant clustering. We have studied the redshift- and duration-dependent clustering of GRBs using proximity measures and kernel density estimation. Utilizing bursts detected by Burst and Transient Source Experiment, Fermi/gamma-ray burst monitor, and Swift/Burst Alert Telescope, we found marginal evidence for clustering inmore » very short duration GRBs lasting less than 100 ms. As a result, our analysis provides little evidence for significant redshift-dependent clustering of GRBs.« less

The Automatic Conservative: Ideology-Based Attentional Asymmetries in the Processing of Valenced Information

PubMed Central

Carraro, Luciana; Castelli, Luigi; Macchiella, Claudia

2011-01-01

Research has widely explored the differences between conservatives and liberals, and it has been also recently demonstrated that conservatives display different reactions toward valenced stimuli. However, previous studies have not yet fully illuminated the cognitive underpinnings of these differences. In the current work, we argued that political ideology is related to selective attention processes, so that negative stimuli are more likely to automatically grab the attention of conservatives as compared to liberals. In Experiment 1, we demonstrated that negative (vs. positive) information impaired the performance of conservatives, more than liberals, in an Emotional Stroop Task. This finding was confirmed in Experiment 2 and in Experiment 3 employing a Dot-Probe Task, demonstrating that threatening stimuli were more likely to attract the attention of conservatives. Overall, results support the conclusion that people embracing conservative views of the world display an automatic selective attention for negative stimuli. PMID:22096486

Operando Positron Annihilation Gamma Spectrometer (OPAGS)

NASA Astrophysics Data System (ADS)

Satyal, S.; Shastry, K.; Mukherjee, S.; Weiss, A. H.

2009-03-01

Surface properties measured under UHV conditions cannot be extended to surfaces interacting with gases under realistic pressures due to surface reconstruction and other strong perturbations of the surface. Surface probing techniques require UHV conditions to perform efficiently and avoid data loss due to scattering of outgoing particles. This poster describes the design of an Operando Positron Annihilation Gamma Spectrometer (OPAGS) currently under construction at the University of Texas at Arlington. The new system will be capable of obtaining surface and defect specific chemical and charge state information from surfaces under realistic pressures. Differential pumping will be used to maintain the sample in a gas environment while the rest of the beam is under UHV. Elemental content of the surface interacting with the gas environment will be determined from the Doppler broadened gamma spectra. This system will also include a time of flight (TOF) Auger spectrometer which correlates with the results of the Doppler measurements at lower pressures. By employing the unique capabilities of OPAGS together with those of the TOF PAES spectroscopy the charge transfer mechanisms at the surface in catalytic systems can be understood.

Development of a Portable Gamma-ray Survey System for the Measurement of Air Dose Rates

NASA Astrophysics Data System (ADS)

Goto, Jun; Shobugawa, Yugo; Kawano, Yoh; Amaya, Yoshihiro; Izumikawa, Takuji; Katsuragi, Yoshinori; Shiiya, Tomohiro; Suzuki, Tsubasa; Takahashi, Takeshi; Takahashi, Toshihiro; Yoshida, Hidenori; Naito, Makoto

BIo-Safety Hybrid Automatic MOnitor-Niigata (BISHAMON), a portable gamma-ray survey system, was developed to support victims of the Fukushima Daiichi nuclear disaster. BISHAMON is capable of constructing a map of the distribution of ambient dose equivalent rates using vehicle-mounted or on-foot survey methods. In this study, we give an overview of BISHAMON and its measurement results including a comparison with those of other systems such as KURAMA.

Automatic Emboli Detection System for the Artificial Heart

NASA Astrophysics Data System (ADS)

Steifer, T.; Lewandowski, M.; Karwat, P.; Gawlikowski, M.

In spite of the progress in material engineering and ventricular assist devices construction, thromboembolism remains the most crucial problem in mechanical heart supporting systems. Therefore, the ability to monitor the patient's blood for clot formation should be considered an important factor in development of heart supporting systems. The well-known methods for automatic embolus detection are based on the monitoring of the ultrasound Doppler signal. A working system utilizing ultrasound Doppler is being developed for the purpose of flow estimation and emboli detection in the clinical artificial heart ReligaHeart EXT. Thesystem will be based on the existing dual channel multi-gate Doppler device with RF digital processing. A specially developed clamp-on cannula probe, equipped with 2 - 4 MHz piezoceramic transducers, enables easy system setup. We present the issuesrelated to the development of automatic emboli detection via Doppler measurements. We consider several algorithms for the flow estimation and emboli detection. We discuss their efficiency and confront them with the requirements of our experimental setup. Theoretical considerations are then met with preliminary experimental findings from a) flow studies with blood mimicking fluid and b) in-vitro flow studies with animal blood. Finally, we discuss some more methodological issues - we consider several possible approaches to the problem of verification of the accuracy of the detection system.

System of Programmed Modules for Measuring Photographs with a Gamma-Telescope

NASA Technical Reports Server (NTRS)

Averin, S. A.; Veselova, G. V.; Navasardyan, G. V.

1978-01-01

Physical experiments using tracking cameras resulted in hundreds of thousands of stereo photographs of events being received. To process such a large volume of information, automatic and semiautomatic measuring systems are required. At the Institute of Space Research of the Academy of Science of the USSR, a system for processing film information from the spark gamma-telescope was developed. The system is based on a BPS-75 projector in line with the minicomputer Elektronika 1001. The report describes this system. The various computer programs available to the operators are discussed.

A novel method to quantify IRDye800CW fluorescent antibody probes ex vivo in tissue distribution studies.

PubMed

Oliveira, Sabrina; Cohen, Ruth; Walsum, Marijke Stigter-van; van Dongen, Guus Ams; Elias, Sjoerd G; van Diest, Paul J; Mali, Willem; van Bergen En Henegouwen, Paul Mp

2012-09-25

We describe a new method for biodistribution studies with IRDye800CW fluorescent antibody probes. This method allows the quantification of the IRDye800CW fluorescent tracer in percentage of injected dose per gram of tissue (% ID/g), and it is herein compared to the generally used reference method that makes use of radioactivity. Cetuximab was conjugated to both the near-infrared fluorophore IRDye800CW and/or the positron emitter 89-zirconium, which was injected in nude mice bearing A431 human tumor xenografts. Positron emission tomography (PET) and optical imaging were performed 24 h post-injection (p.i.). For the biodistribution study, organs and tumors were collected 24 h p.i., and each of these was halved. One half was used for the determination of probe uptake by radioactivity measurement. The other half was homogenized, and the content of the fluorescent probe was determined by extrapolation from a calibration curve made with the injected probe. Tumors were clearly visualized with both modalities, and the calculated tumor-to-normal tissue ratios were very similar for optical and PET imaging: 3.31 ± 1.09 and 3.15 ± 0.99, respectively. Although some variations were observed in ex vivo analyses, tumor uptake was within the same range for IRDye800CW and gamma ray quantification: 15.07 ± 3.66% ID/g and 13.92 ± 2.59% ID/g, respectively. The novel method for quantification of the optical tracer IRDye800CW gives similar results as the reference method of gamma ray quantification. This new method is considered very useful in the context of the preclinical development of IRDye800CW fluorescent probes for optical molecular imaging, likely contributing to the selection of lead compounds that are the most promising for clinical translation.

In vivo reproducibility of robotic probe placement for a novel ultrasound-guided radiation therapy system

PubMed Central

Lediju Bell, Muyinatu A.; Sen, H. Tutkun; Iordachita, Iulian; Kazanzides, Peter; Wong, John

2014-01-01

Abstract. Ultrasound can provide real-time image guidance of radiation therapy, but the probe-induced tissue deformations cause local deviations from the treatment plan. If placed during treatment planning, the probe causes streak artifacts in required computed tomography (CT) images. To overcome these challenges, we propose robot-assisted placement of an ultrasound probe, followed by replacement with a geometrically identical, CT-compatible model probe. In vivo reproducibility was investigated by implanting a canine prostate, liver, and pancreas with three 2.38-mm spherical markers in each organ. The real probe was placed to visualize the markers and subsequently replaced with the model probe. Each probe was automatically removed and returned to the same position or force. Under position control, the median three-dimensional reproducibility of marker positions was 0.6 to 0.7 mm, 0.3 to 0.6 mm, and 1.1 to 1.6 mm in the prostate, liver, and pancreas, respectively. Reproducibility was worse under force control. Probe substitution errors were smallest for the prostate (0.2 to 0.6 mm) and larger for the liver and pancreas (4.1 to 6.3 mm), where force control generally produced larger errors than position control. Results indicate that position control is better than force control for this application, and the robotic approach has potential, particularly for relatively constrained organs and reproducibility errors that are smaller than established treatment margins. PMID:26158038

Cosmic Rays and Gamma-Rays in Large-Scale Structure

NASA Astrophysics Data System (ADS)

Inoue, Susumu; Nagashima, Masahiro; Suzuki, Takeru K.; Aoki, Wako

2004-12-01

During the hierarchical formation of large scale structure in the universe, the progressive collapse and merging of dark matter should inevitably drive shocks into the gas, with nonthermal particle acceleration as a natural consequence. Two topics in this regard are discussed, emphasizing what important things nonthermal phenomena may tell us about the structure formation (SF) process itself. 1. Inverse Compton gamma-rays from large scale SF shocks and non-gravitational effects, and the implications for probing the warm-hot intergalactic medium. We utilize a semi-analytic approach based on Monte Carlo merger trees that treats both merger and accretion shocks self-consistently. 2. Production of 6Li by cosmic rays from SF shocks in the early Galaxy, and the implications for probing Galaxy formation and uncertain physics on sub-Galactic scales. Our new observations of metal-poor halo stars with the Subaru High Dispersion Spectrograph are highlighted.

Canister cryogenic system for cooling germanium semiconductor detectors in borehole and marine probes

USGS Publications Warehouse

Boynton, G.R.

1975-01-01

High resolution intrinsic and lithium-drifted germanium gamma-ray detectors operate at about 77-90 K. A cryostat for borehole and marine applications has been designed that makes use of prefrozen propane canisters. Uses of such canisters simplifies cryostat construction, and the rapid exchange of canisters greatly reduces the time required to restore the detector to full holding-time capability and enhances the safety of a field operation where high-intensity 252Cf or other isotopic sources are used. A holding time of 6 h at 86 K was achieved in the laboratory in a simulated borehole probe in which a canister 3.7 cm diameter by 57 cm long was used. Longer holding times can be achieved by larger volume canisters in marine probes. ?? 1975.

Detection of GRB 060927 at zeta = 5.47: Implications for the Use of Gamma-Ray Bursts as Probes of the End of the Dark Ages

NASA Technical Reports Server (NTRS)

Ruiz-Velasco, A. E.; Swan, H.; Troja, E.; Malesani, D.; Fynbo, J. P. U.; Sterling, R. L. C.; Xu, D.; Aharonian, F.; Akerlof, C.; Andersen, M. I.;

Indirect detection of Particle Dark Matter with gamma rays - status and perspectives

NASA Astrophysics Data System (ADS)

Conrad, Jan

2014-03-01

In this contribution I review the present status and discuss some prospects for indirect detection of dark matter with gamma rays. Thanks mainly to the Fermi Large Area Telescope (Fermi-LAT), searches in gamma-rays have reached sensitivities that allow to probe the most interesting parameter space of the weakly interacting massive particles (WIMP) paradigm. This gain in sensitivity is naturally accompanied by a number of detection claims or indications. At WIMP masses above roughly a TeV current Imaging Air Cherenkov Telescopes (HESS, VERITAS, MAGIC) become more sensitive than the Fermi-LAT, the most promising recent development being the first light for the second phase HESS II telescope with significantly lower energy threshold. Predictions for the next generation air Cherenkov telescope, Cherenkov Telescope Array (CTA), together with forecasts on future Fermi-LAT constraints arrive at the exciting possibility that the cosmological benchmark cross-section could be probed from masses of a few GeV to a few TeV. Consequently, non-detection would pose a challenge to the WIMP paradigm, but the reached sensitivities also imply that-optimistically-a detection within the next decade is in the cards. Time allowing, I will comment on complementarity between the different approaches to WIMP detection.

Average capacity of the ground to train communication link of a curved track in the turbulence of gamma-gamma distribution

NASA Astrophysics Data System (ADS)

Yang, Yanqiu; Yu, Lin; Zhang, Yixin

2017-04-01

A model of the average capacity of optical wireless communication link with pointing errors for the ground-to-train of the curved track is established based on the non-Kolmogorov. By adopting the gamma-gamma distribution model, we derive the average capacity expression for this channel. The numerical analysis reveals that heavier fog reduces the average capacity of link. The strength of atmospheric turbulence, the variance of pointing errors, and the covered track length need to be reduced for the larger average capacity of link. The normalized beamwidth and the average signal-to-noise ratio (SNR) of the turbulence-free link need to be increased. We can increase the transmit aperture to expand the beamwidth and enhance the signal intensity, thereby decreasing the impact of the beam wander accordingly. As the system adopting the automatic tracking of beam at the receiver positioned on the roof of the train, for eliminating the pointing errors caused by beam wander and train vibration, the equivalent average capacity of the channel will achieve a maximum value. The impact of the non-Kolmogorov spectral index's variation on the average capacity of link can be ignored.

Intraoperative Imaging Guidance for Sentinel Node Biopsy in Melanoma Using a Mobile Gamma Camera

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dengel, Lynn T; Judy, Patricia G; Petroni, Gina R

2011-04-01

The objective is to evaluate the sensitivity and clinical utility of intraoperative mobile gamma camera (MGC) imaging in sentinel lymph node biopsy (SLNB) in melanoma. The false-negative rate for SLNB for melanoma is approximately 17%, for which failure to identify the sentinel lymph node (SLN) is a major cause. Intraoperative imaging may aid in detection of SLN near the primary site, in ambiguous locations, and after excision of each SLN. The present pilot study reports outcomes with a prototype MGC designed for rapid intraoperative image acquisition. We hypothesized that intraoperative use of the MGC would be feasible and that sensitivitymore » would be at least 90%. From April to September 2008, 20 patients underwent Tc99 sulfur colloid lymphoscintigraphy, and SLNB was performed with use of a conventional fixed gamma camera (FGC), and gamma probe followed by intraoperative MGC imaging. Sensitivity was calculated for each detection method. Intraoperative logistical challenges were scored. Cases in which MGC provided clinical benefit were recorded. Sensitivity for detecting SLN basins was 97% for the FGC and 90% for the MGC. A total of 46 SLN were identified: 32 (70%) were identified as distinct hot spots by preoperative FGC imaging, 31 (67%) by preoperative MGC imaging, and 43 (93%) by MGC imaging pre- or intraoperatively. The gamma probe identified 44 (96%) independent of MGC imaging. The MGC provided defined clinical benefit as an addition to standard practice in 5 (25%) of 20 patients. Mean score for MGC logistic feasibility was 2 on a scale of 1-9 (1 = best). Intraoperative MGC imaging provides additional information when standard techniques fail or are ambiguous. Sensitivity is 90% and can be increased. This pilot study has identified ways to improve the usefulness of an MGC for intraoperative imaging, which holds promise for reducing false negatives of SLNB for melanoma.« less

Probing dimensionality using a simplified 4-probe method.

PubMed

Kjeldby, Snorre B; Evenstad, Otto M; Cooil, Simon P; Wells, Justin W

2017-10-04

4-probe electrical measurements have been in existence for many decades. One of the most useful aspects of the 4-probe method is that it is not only possible to find the resistivity of a sample (independently of the contact resistances), but that it is also possible to probe the dimensionality of the sample. In theory, this is straightforward to achieve by measuring the 4-probe resistance as a function of probe separation. In practice, it is challenging to move all four probes with sufficient precision over the necessary range. Here, we present an alternative approach. We demonstrate that the dimensionality of the conductive path within a sample can be directly probed using a modified 4-probe method in which an unconventional geometry is exploited; three of the probes are rigidly fixed, and the position of only one probe is changed. This allows 2D and 3D (and other) contributions the to resistivity to be readily disentangled. The required experimental instrumentation can be vastly simplified relative to traditional variable spacing 4-probe instruments.

Data analysis of P sub T/P sub S noseboom probe testing on F100 engine P680072 at NASA Lewis Research Center

NASA Technical Reports Server (NTRS)

Foote, C. H.

1980-01-01

Results from the altitude testing of a P sub T/P sub S noseboom probe on the F100 engine are discused. The results are consistent with sea level test results. The F100 engine altitude test verified automatic downmatch with the engine pressure ratio control, and backup control inlet case static pressure demonstrated sufficient accuracy for backup control fuel flow scheduling. The production P6 probe measured Station 6 pressures accurately for both undistorted and distorted inlet airflows.

gamma-Hexachlorocyclohexane (gamma-HCH)

Integrated Risk Information System (IRIS)

gamma - Hexachlorocyclohexane ( gamma - HCH ) ; CASRN 58 - 89 - 9 Human health assessment information on a chemical substance is included in the IRIS database only after a comprehensive review of toxicity data , as outlined in the IRIS assessment development process . Sections I ( Health Hazard Asse

Back-to-back optical coherence tomography-ultrasound probe for co-registered three-dimensional intravascular imaging with real-time display

NASA Astrophysics Data System (ADS)

Li, Jiawen; Ma, Teng; Jing, Joseph; Zhang, Jun; Patel, Pranav M.; Shung, K. Kirk; Zhou, Qifa; Chen, Zhongping

2014-03-01

We have developed a novel integrated optical coherence tomography (OCT)-intravascular ultrasound (IVUS) probe, with a 1.5 mm-long rigid-part and 0.9 mm outer diameter, for real-time intracoronary imaging of atherosclerotic plaques and guiding interventional procedures. By placing the OCT ball lens and IVUS 45MHz single element transducer back-to-back at the same axial position, this probe can provide automatically co-registered, co-axial OCT-IVUS imaging. To demonstrate its capability, 3D OCT-IVUS imaging of a pig's coronary artery in real-time displayed in polar coordinates, as well as images of two major types of advanced plaques in human cadaver coronary segments, was obtained using this probe and our upgraded system. Histology validation is also presented.

Design of an Operando Positron Annihilation Gamma Spectrometer (OPAGS)

NASA Astrophysics Data System (ADS)

Satyal, S.; Joglekar, P.; Kalaskar, S.; Shastry, K.; Weiss, A. H.

2010-03-01

Surface properties measured under UHV conditions cannot be extended to surfaces interacting with gases under realistic pressures due to surface reconstruction and other strong perturbations of the surface. We present the design of an Operando Positron Annihilation Gamma Spectrometer (OPAGS) currently under construction at the University of Texas at Arlington. This new system will enable us to probe the surface and gather defect specific chemical and charge state information from surfaces under realistic pressures. Differential pumping will be used to maintain the sample in a gas environment while the rest of the beam is maintained under UHV. The Elemental content of the surface interacting with the gas environment will be determined from the Doppler broadened gamma spectra. This system will include a time of flight (TOF) positron annihilation induced Auger spectrometer (TOF-PAES) which correlates with the Doppler measurements at lower pressures. These new technique help to understand the charge transfer mechanisms at the surface.

CFHT's SkyProbe: True Atmospheric Attenuation Measurement in the Telescope Field

NASA Astrophysics Data System (ADS)

Cuillandre, J.-C.; Magnier, E. A.; Isani, S.; Sabin, D.; Knight, W.; Kras, S.; Lai, K.

Developed at the Canada France Hawaii Telescope (CFHT), SkyProbe is a system that allows the direct measurement of the true attenuation by clouds. This measurement is performed approximately once per min, directly on the field viewed by the telescope. It has been possible to make this system relatively inexpensively due to low cost CCD cameras available on the amateur market. A crucial addition to this hardware is the recent availability of a full-sky photometry catalog at the appropriate depth: the Tycho catalog from the Hipparcos mission. A very important element in the SkyProbe data set creation is the automatic data analysis pipeline, Elixir, developed at CFHT for the improved operation of the CFHT wide-field imagers CFH12K and MegaCam. SkyProbe's FITS images are processed in real time, and the pipeline output (a zero point attenuation) provides the current sky transmission to the observers and aids immediate decision making. These measurements are also attached to the archived data, adding a key tool for future use by other astronomers. Specific features of the detector, such as intra pixel quantum efficiency variations, must be taken into consideration since the data are strongly undersampled.

Automatic fluid dispenser

NASA Technical Reports Server (NTRS)

Sakellaris, P. C. (Inventor)

1977-01-01

Fluid automatically flows to individual dispensing units at predetermined times from a fluid supply and is available only for a predetermined interval of time after which an automatic control causes the fluid to drain from the individual dispensing units. Fluid deprivation continues until the beginning of a new cycle when the fluid is once again automatically made available at the individual dispensing units.

Probing the X-ray Emission from the Massive Star Cluster Westerlund 2

NASA Astrophysics Data System (ADS)

Lopez, Laura

2017-09-01

We propose a 300 ks Chandra ACIS-I observation of the massive star cluster Westerlund 2 (Wd2). This region is teeming with high-energy emission from a variety of sources: colliding wind binaries, OB and Wolf-Rayet stars, two young pulsars, and an unidentified source of very high-energy (VHE) gamma-rays. Our Chandra program is designed to achieve several goals: 1) to take a complete census of Wd2 X-ray point sources and monitor variability; 2) to probe the conditions of the colliding winds in the binary WR 20a; 3) to search for an X-ray counterpart of the VHE gamma-rays; 4) to identify diffuse X-ray emission; 5) to compare results to other massive star clusters observed by Chandra. Only Chandra has the spatial resolution and sensitivity necessary for our proposed analyses.

First light from the Vela pulsar with the Fermi Gamma-ray Space Telescope

NASA Astrophysics Data System (ADS)

Razzano, M.

2009-04-01

The Fermi Gamma-ray Space Telescope, launched in June 2008, is an international space mission entirely devoted to the study of the high-energy gamma rays from the Universe. The main instrument aboard Fermi is the Large Area Telescope (LAT), a pair conversion telescope equipped with the state-of-the art in gamma-ray detectors technology. Thanks to its large field of view and effective area, combined with its excellent timing capability, Fermi-LAT is a perfect instrument for probing physics of gamma-ray emission in pulsars. LAT is expected to discover tens of new pulsars, both radio-loud and radio-quiet (Geminga-like). Moreover, LAT will observe with unprecedented statistics the brightest pulsars, investigating the details of magnetospheric emission. The first two months of the mission have been focused on the commissioning and first light, during which the LAT firmly detected the six previously known EGRET gamma-ray pulsars. One of the main sources of interest during our first light observations has been the Vela pulsar, the brightest persistent source in the whole gamma-ray sky. Thanks to its brightness, the Vela pulsar is an ideal candidate for calibrating the LAT and testing its performance. In addition, observations of Vela will help answer many questions related to the physics of pulsar emission processes. We present here some recent results obtained by the LAT on the Vela pulsar, using high-quality timing solutions provided by radio observations carried out within the Fermi pulsar radio timing campaign.

Gamma Irradiation and Oxidative Degradation of a Silica-Filled Silicone Elastomer

DOE PAGES

Labouriau, Andrea; Cady, Carl Mcelhinney; Gill, John T.; ...

2015-03-21

The radiation oxidative degradation of a commonly used silica-filled silicone elastomer DC745 was investigated by a series of experimental techniques. This elastomer is known to be chemically and thermally stable, but insufficient data exist on the radiation resistance. In the present work, gamma doses up to 200 kGy were applied under air at RT and 1Gy/s. Radiation chemical changes were investigated by NMR, FT-IR, Raman, and mass spectroscopy. DSC and TGA experiments probed thermal transitions and thermal stability changes with exposure dose. SEM probed variations on the surface of the elastomer, and solvent swelling methods were used to investigate changesmore » in the polymer network properties. Electron paramagnetic resonance was employed to detect and identify free radicals. Uniaxial compression load tests at variable temperatures were performed to assess changes in the material’s mechanical response as a function of radiation dose. Results demonstrate that, with increasing exposure, DC745 undergoes changes in chemistry that lead to an increase in thermal stability and cross-link density, formation of free radical species, decrease in heat of fusion and increase in stiffness at low temperatures. Taken together, these results indicate that oxidative cross-linking is the dominant radiolysis mechanism that occurs when this material is exposed to gamma irradiation in air at high dose rates.« less

Gamma Irradiation and Oxidative Degradation of a Silica-Filled Silicone Elastomer

DOE Office of Scientific and Technical Information (OSTI.GOV)

Labouriau, Andrea; Cady, Carl Mcelhinney; Gill, John T.

The radiation oxidative degradation of a commonly used silica-filled silicone elastomer DC745 was investigated by a series of experimental techniques. This elastomer is known to be chemically and thermally stable, but insufficient data exist on the radiation resistance. In the present work, gamma doses up to 200 kGy were applied under air at RT and 1Gy/s. Radiation chemical changes were investigated by NMR, FT-IR, Raman, and mass spectroscopy. DSC and TGA experiments probed thermal transitions and thermal stability changes with exposure dose. SEM probed variations on the surface of the elastomer, and solvent swelling methods were used to investigate changesmore » in the polymer network properties. Electron paramagnetic resonance was employed to detect and identify free radicals. Uniaxial compression load tests at variable temperatures were performed to assess changes in the material’s mechanical response as a function of radiation dose. Results demonstrate that, with increasing exposure, DC745 undergoes changes in chemistry that lead to an increase in thermal stability and cross-link density, formation of free radical species, decrease in heat of fusion and increase in stiffness at low temperatures. Taken together, these results indicate that oxidative cross-linking is the dominant radiolysis mechanism that occurs when this material is exposed to gamma irradiation in air at high dose rates.« less

Unidentified Gamma-Ray Sources: Hunting Gamma-Ray Blazars

DOE Office of Scientific and Technical Information (OSTI.GOV)

Massaro, F.; D'Abrusco, R.; Tosti, G.

2012-04-02

One of the main scientific objectives of the ongoing Fermi mission is unveiling the nature of the unidentified {gamma}-ray sources (UGSs). Despite the large improvements of Fermi in the localization of {gamma}-ray sources with respect to the past {gamma}-ray missions, about one third of the Fermi-detected objects are still not associated to low energy counterparts. Recently, using the Wide-field Infrared Survey Explorer (WISE) survey, we discovered that blazars, the rarest class of Active Galactic Nuclei and the largest population of {gamma}-ray sources, can be recognized and separated from other extragalactic sources on the basis of their infrared (IR) colors. Basedmore » on this result, we designed an association method for the {gamma}-ray sources to recognize if there is a blazar candidate within the positional uncertainty region of a generic {gamma}-ray source. With this new IR diagnostic tool, we searched for {gamma}-ray blazar candidates associated to the UGS sample of the second Fermi {gamma}-ray catalog (2FGL). We found that our method associates at least one {gamma}-ray blazar candidate as a counterpart each of 156 out of 313 UGSs analyzed. These new low-energy candidates have the same IR properties as the blazars associated to {gamma}-ray sources in the 2FGL catalog.« less

UNIDENTIFIED {gamma}-RAY SOURCES: HUNTING {gamma}-RAY BLAZARS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Massaro, F.; Ajello, M.; D'Abrusco, R.

2012-06-10

One of the main scientific objectives of the ongoing Fermi mission is unveiling the nature of unidentified {gamma}-ray sources (UGSs). Despite the major improvements of Fermi in the localization of {gamma}-ray sources with respect to the past {gamma}-ray missions, about one-third of the Fermi-detected objects are still not associated with low-energy counterparts. Recently, using the Wide-field Infrared Survey Explorer survey, we discovered that blazars, the rarest class of active galactic nuclei and the largest population of {gamma}-ray sources, can be recognized and separated from other extragalactic sources on the basis of their infrared (IR) colors. Based on this result, wemore » designed an association method for the {gamma}-ray sources to recognize if there is a blazar candidate within the positional uncertainty region of a generic {gamma}-ray source. With this new IR diagnostic tool, we searched for {gamma}-ray blazar candidates associated with the UGS sample of the second Fermi {gamma}-ray LAT catalog (2FGL). We found that our method associates at least one {gamma}-ray blazar candidate as a counterpart to each of 156 out of 313 UGSs analyzed. These new low-energy candidates have the same IR properties as the blazars associated with {gamma}-ray sources in the 2FGL catalog.« less

Gamma Ray Burst Discoveries by the Swift Mission

NASA Technical Reports Server (NTRS)

Gehrels, Neil

2006-01-01

Gamma-ray bursts are among the most fascinating occurrences in the cosmos. They are thought to be the birth cries of black holes throughout the universe. The NASA Swift mission is an innovative new multiwavelength observatory designed to determine the origin of bursts and use them to probe the early Universe. Swift is now in orbit after a beautiful launch on November 20, 2004. A new-technology wide-field gamma-ray camera detects more than a hundred bursts per year. Sensitive narrow-field X-ray and UV/optical telescopes, built in collaboration with UK and Italian partners and calibrated in Germany, are pointed at the burst location in 20 to 70 sec by an autonomously controlled "swift" spacecraft. For each burst, arcsec positions are determined and optical/UV/X-ray/gamma-ray spectrophotometry performed. Information is also rapidly sent to the ground to a team of more than 50 observers at telescopes around the world. Early results from the mission will be presented. The long-standing mystery of short GRBs has been solved, and the answer is the most interesting possible scenario. High redshift bursts have been detected leading to a better understanding of star formation rates and distant galaxy environments. GRBs have been found with giant X-ray flares occurring in their afterglow. Observations of magnetars, galactic transients, supernovae, AGN and many other types of sources are also being performed

Gamma Ray Burst Discoveries by the Swift Mission

NASA Astrophysics Data System (ADS)

Gehrels, N.; Swift Team

2005-12-01

Gamma-ray bursts are among the most fascinating occurrences in the cosmos. They are thought to be the birth cries of black holes throughout the universe. The NASA Swift mission is an innovative new multiwavelength observatory designed to determine the origin of bursts and use them to probe the early Universe. Swift is now in orbit after a beautiful launch on November 20, 2004. A new-technology wide-field gamma-ray camera detects more than a hundred bursts per year. Sensitive narrow-field X-ray and UV/optical telescopes, built in collaboration with UK and Italian partners, are pointed at the burst location in 20 to 70 sec by an autonomously controlled "swift" spacecraft. For each burst, arcsec positions are determined and optical/UV/X-ray/gamma-ray spectrophotometry performed. Information is also rapidly sent to the ground to a team of more than 50 observers at telescopes around the world. The first year of findings from the mission will be presented. The long-standing mystery of short GRBs has been solved, and the answer is the most interesting possible scenario. High redshift bursts have been detected leading to a better understanding of star formation rates and distant galaxy environments. GRBs have been found with giant X-ray flares occurring in their afterglow. These, and other topics, will be discussed.

Gamma Ray Burst Discoveries by the Swift Mission

NASA Astrophysics Data System (ADS)

Gehrels, Neil

2006-04-01

Gamma-ray bursts are among the most fascinating occurrences in the cosmos. They are thought to be the birth cries of black holes throughout the universe. The NASA Swift mission is an innovative new multiwavelength observatory designed to determine the origin of bursts and use them to probe the early Universe. Swift is now in orbit since November 20, 2004 and all hardware is performing well. A new-technology wide-field gamma-ray camera is detecting a hundred bursts per year. Sensitive narrow-field X-ray and UV/optical telescopes, built in collaboration with UK and Italian partners, are pointed at the burst location in 50-100 sec by an autonomously controlled ``swift'' spacecraft. For each burst, arcsec positions are determined and optical/UV/X-ray/gamma-ray spectrophotometry performed. Information is also rapidly sent to the ground to a team of more than 50 observers at telescopes around the world. The first year of findings from the mission will be presented. There has been a break-through in the long-standing mystery of short GRBs; they appear to be caused by merging neutron stars. High redshift bursts have been detected leading to a better understanding of star formation rates and distant galaxy environments. GRBs have been found with giant X-ray flares occurring in their afterglow.

Gamma Ray Burst Discoveries by the Swift Mission

NASA Technical Reports Server (NTRS)

Gehrels, Neil

2006-01-01

Gamma-ray bursts are among the most fascinating occurrences in the cosmos. They are thought to be the birth cries of black holes throughout the universe. The NASA swift mission is an innovative new multiwavelength observatory designed to determine the origin of bursts and use them to probe the early Universe. Swift is now in orbit since November 20, 2004 and all hardware is performing well. A new-technology wide-field gamma-ray camera is detecting a hundred bursts per year. sensitive narrow-field X-ray and uv/optical telescopes, built in collaboration with UK and Italian partners, are pointed at the burst location in 50-100 sec by an autonomously controlled "swift" spacecraft. For each burst, arcsec positions are determined and optical/UV/X-ray/gamma-ray spectrophotometry performed. Information is also rapidly sent to the ground to a team of more than 50 observers at telescopes around the world. The first year of findings from the mission will be presented. There has been a break-through in the longstanding mystery of short GRBs; they appear to be caused by merging neutron stars. High redshift bursts have been detected leading to a better understanding of star formation rates and distant galaxy environments. GRBs have been found with giant X-ray flares occurring in their afterglow.

Gamma Ray Burst Discoveries by the Swift Mission

NASA Technical Reports Server (NTRS)

Gehrels, Neil

2006-01-01

Gamma-ray bursts are among the most fascinating occurrences in the cosmos. They are thought to be the birth cries of black holes throughout the universe. The NASA Swift mission is an innovative new multiwavelength observatory designed to determine the origin of bursts and use them to probe the early Universe. Swift is now in orbit after a beautiful launch on November 20, 2004. A new-technology wide-field gamma-ray camera detects more than a hundred bursts per year. Sensitive narrow-field X-ray and UV/optical telescopes, built in collaboration with UK and Italian partners, are pointed at the burst location in 20 to 70 sec by an autonomously controlled "swift" spacecraft. For each burst, arcsec positions are determined and optical/UV/X-ray/gamma-ray spectrophotometry performed. Information is also rapidly sent to the ground to a team of more than 50 observers at telescopes around the world. The first year of findings from the mission will be presented. The long-standing mystery of short GRBs has been solved, and the answer is the most interesting possible scenario. High redshift bursts have been detected leading to a better understanding of star formation rates and distant galaxy environments. GRBs have been found with giant X-ray flares occurring in their afterglow. These, and other topics, will be discussed.

CFHT's SkyProbe: a real-time sky-transparency monitor

NASA Astrophysics Data System (ADS)

Cuillandre, Jean-Charles; Magnier, Eugene A.; Isani, Sidik; Sabin, Daniel; Knight, Wiley; Kras, Simon; Lai, Kamson

2002-12-01

We have developed a system at the Canada-France-Hawaii Telescope (CFHT), SkyProbe, which allows for the direct measurement of the true attenuation by clouds once per minute, within a percent, directly on the field pointed by the telescope. It has been possible to make this system relatively inexpensively due to the low-cost CCD cameras from the amateur market. A crucial addition to this hardware is the quite recent availability of a full-sky photometry catalog at the appropriate depth: the Tycho catalog, from the Hipparcos mission. The central element is the automatic data analysis pipeline developed at CFHT, Elixir, for the improved operation of the CFHT wide-field imagers, CFH12K and MegaCam. SkyProbe"s FITS images are processed in real-time and the pipeline output (a zero point attenuation) provides the current sky transmission to the observers and helps immediate decision making. These measurements are also attached to the archived data, adding a key criteria for future use by other astronomers.

Optical method for distance and displacement measurements of the probe-sample separation in a scanning near-field optical microscope

DOE Office of Scientific and Technical Information (OSTI.GOV)

Santamaria, L.; Siller, H. R.; Garcia-Ortiz, C. E., E-mail: cegarcia@cicese.mx

In this work, we present an alternative optical method to determine the probe-sample separation distance in a scanning near-field optical microscope. The experimental method is based in a Lloyd’s mirror interferometer and offers a measurement precision deviation of ∼100 nm using digital image processing and numerical analysis. The technique can also be strategically combined with the characterization of piezoelectric actuators and stability evaluation of the optical system. It also opens the possibility for the development of an automatic approximation control system valid for probe-sample distances from 5 to 500 μm.

Xe isotope detection and discrimination using beta spectroscopy with coincident gamma spectroscopy

NASA Astrophysics Data System (ADS)

Reeder, P. L.; Bowyer, T. W.

1998-02-01

Beta spectroscopic techniques show promise of significant improvements for a beta-gamma coincidence counter that is part of a system for analyzing Xe automatically separated from air. The previously developed counting system for 131mXe, 133mXe, 133gXe, and 135gXe can be enhanced to give additional discrimination between these Xe isotopes by using the plastic scintillation sample cell as a beta spectrometer to resolve the conversion electron peaks. The automated system will be a key factor in monitoring the Comprehensive Test Ban Treaty.

Gamma-ray irradiation of ohmic MEMS switches

NASA Astrophysics Data System (ADS)

Maciel, John J.; Lampen, James L.; Taylor, Edward W.

2012-10-01

Radio Frequency (RF) Microelectromechanical System (MEMS) switches are becoming important building blocks for a variety of military and commercial applications including switch matrices, phase shifters, electronically scanned antennas, switched filters, Automatic Test Equipment, instrumentation, cell phones and smart antennas. Low power consumption, large ratio of off-impedance to on-impedance, extreme linearity, low mass, small volume and the ability to be integrated with other electronics makes MEMS switches an attractive alternative to other mechanical and solid-state switches for a variety of space applications. Radant MEMS, Inc. has developed an electrostatically actuated broadband ohmic microswitch that has applications from DC through the microwave region. Despite the extensive earth based testing, little is known about the performance and reliability of these devices in space environments. To help fill this void, we have irradiated our commercial-off-the-shelf SPST, DC to 40 GHz MEMS switches with gamma-rays as an initial step to assessing static impact on RF performance. Results of Co-60 gamma-ray irradiation of the MEMS switches at photon energies ≥ 1.0 MeV to a total dose of ~ 118 krad(Si) did not show a statistically significant post-irradiation change in measured broadband, RF insertion loss, insertion phase, return loss and isolation.

Growth kinetics of gamma-prime precipitates in a directionally solidified eutectic, gamma/gamma-prime-delta

NASA Technical Reports Server (NTRS)

Tewari, S. N.

1976-01-01

A directionally solidified eutectic alloy (DSEA), of those viewed as potential candidates for the next generation of aircraft gas turbine blade materials, is studied for the gamma-prime growth kinetics, in the system Ni-Nb-Cr-Al, specifically: Ni-20 w/o Nb-6 w/o Cr-2.5 w/o Al gamma/gamma-prime-delta DSEA. Heat treatment, polishing and etching, and preparation for electron micrography are described, and the size distribution of gamma-prime phase following various anneals is plotted, along with gamma-prime growth kinetics in this specific DSEA, and the cube of gamma-prime particle size vs anneal time. Activation energies and coarsening kinetics are studied.

The neutron-gamma Feynman variance to mean approach: Gamma detection and total neutron-gamma detection (theory and practice)

NASA Astrophysics Data System (ADS)

Chernikova, Dina; Axell, Kåre; Avdic, Senada; Pázsit, Imre; Nordlund, Anders; Allard, Stefan

2015-05-01

Two versions of the neutron-gamma variance to mean (Feynman-alpha method or Feynman-Y function) formula for either gamma detection only or total neutron-gamma detection, respectively, are derived and compared in this paper. The new formulas have particular importance for detectors of either gamma photons or detectors sensitive to both neutron and gamma radiation. If applied to a plastic or liquid scintillation detector, the total neutron-gamma detection Feynman-Y expression corresponds to a situation where no discrimination is made between neutrons and gamma particles. The gamma variance to mean formulas are useful when a detector of only gamma radiation is used or when working with a combined neutron-gamma detector at high count rates. The theoretical derivation is based on the Chapman-Kolmogorov equation with the inclusion of general reactions and corresponding intensities for neutrons and gammas, but with the inclusion of prompt reactions only. A one energy group approximation is considered. The comparison of the two different theories is made by using reaction intensities obtained in MCNPX simulations with a simplified geometry for two scintillation detectors and a 252Cf-source. In addition, the variance to mean ratios, neutron, gamma and total neutron-gamma are evaluated experimentally for a weak 252Cf neutron-gamma source, a 137Cs random gamma source and a 22Na correlated gamma source. Due to the focus being on the possibility of using neutron-gamma variance to mean theories for both reactor and safeguards applications, we limited the present study to the general analytical expressions for Feynman-alpha formulas.

Comparative evaluation of probing depth and clinical attachment level using a manual probe and Florida probe.

PubMed

Kour, Amandeep; Kumar, Ashish; Puri, Komal; Khatri, Manish; Bansal, Mansi; Gupta, Geeti

2016-01-01

To compare and evaluate the intra- and inter-examiner efficacy and reproducibility of the first-generation manual (Williams) probe and the third-generation Florida probe in terms of measuring pocket probing depth (PD) and clinical attachment level (CAL). Forty subjects/4000 sites were included in this comparative, cross-sectional study. Group- and site-wise categorizations were done. Based on gingival index, PD, and CAL, patients were divided into four groups, i.e., periodontally healthy, gingivitis, mild to moderate periodontitis, and severe periodontitis. Further, based on these parameters, a total of 4000 sites, with 1000 sites in each category randomly selected from these 40 patients, were taken. Full mouth PD and CAL measurements were recorded with two probes, by Examiner 1 and on Ramfjord teeth by Examiner 2. Full mouth and Ramfjord teeth group- and site-wise PD obtained with the manual probe by both the examiners were statistically significantly deeper than that obtained with the Florida probe. The full mouth and Ramfjord teeth mean CAL measurement by Florida probe was higher as compared to manual probe in mild to moderate periodontitis group and sites, whereas in severe periodontitis group and sites, manual probe recorded higher CAL as compared to Florida probe. Mean PD and CAL measurements were deeper with the manual probe as compared to the Florida probe in all the groups and sites, except for the mild-moderate periodontitis group and sites where the CAL measurements with the manual probe were less than the Florida probe. Manual probe was more reproducible and showed less interexaminer variability as compared to the Florida probe.

Attention to Automatic Movements in Parkinson's Disease: Modified Automatic Mode in the Striatum

PubMed Central

Wu, Tao; Liu, Jun; Zhang, Hejia; Hallett, Mark; Zheng, Zheng; Chan, Piu

2015-01-01

We investigated neural correlates when attending to a movement that could be made automatically in healthy subjects and Parkinson's disease (PD) patients. Subjects practiced a visuomotor association task until they could perform it automatically, and then directed their attention back to the automated task. Functional MRI was obtained during the early-learning, automatic stage, and when re-attending. In controls, attention to automatic movement induced more activation in the dorsolateral prefrontal cortex (DLPFC), anterior cingulate cortex, and rostral supplementary motor area. The motor cortex received more influence from the cortical motor association regions. In contrast, the pattern of the activity and connectivity of the striatum remained at the level of the automatic stage. In PD patients, attention enhanced activity in the DLPFC, premotor cortex, and cerebellum, but the connectivity from the putamen to the motor cortex decreased. Our findings demonstrate that, in controls, when a movement achieves the automatic stage, attention can influence the attentional networks and cortical motor association areas, but has no apparent effect on the striatum. In PD patients, attention induces a shift from the automatic mode back to the controlled pattern within the striatum. The shifting between controlled and automatic behaviors relies in part on striatal function. PMID:24925772

[Wearable Automatic External Defibrillators].

PubMed

Luo, Huajie; Luo, Zhangyuan; Jin, Xun; Zhang, Leilei; Wang, Changjin; Zhang, Wenzan; Tu, Quan

2015-11-01

Defibrillation is the most effective method of treating ventricular fibrillation(VF), this paper introduces wearable automatic external defibrillators based on embedded system which includes EGG measurements, bioelectrical impedance measurement, discharge defibrillation module, which can automatic identify VF signal, biphasic exponential waveform defibrillation discharge. After verified by animal tests, the device can realize EGG acquisition and automatic identification. After identifying the ventricular fibrillation signal, it can automatic defibrillate to abort ventricular fibrillation and to realize the cardiac electrical cardioversion.

Visual Benefits in Apparent Motion Displays: Automatically Driven Spatial and Temporal Anticipation Are Partially Dissociated

PubMed Central

Ahrens, Merle-Marie; Veniero, Domenica; Gross, Joachim; Harvey, Monika; Thut, Gregor

2015-01-01

Many behaviourally relevant sensory events such as motion stimuli and speech have an intrinsic spatio-temporal structure. This will engage intentional and most likely unintentional (automatic) prediction mechanisms enhancing the perception of upcoming stimuli in the event stream. Here we sought to probe the anticipatory processes that are automatically driven by rhythmic input streams in terms of their spatial and temporal components. To this end, we employed an apparent visual motion paradigm testing the effects of pre-target motion on lateralized visual target discrimination. The motion stimuli either moved towards or away from peripheral target positions (valid vs. invalid spatial motion cueing) at a rhythmic or arrhythmic pace (valid vs. invalid temporal motion cueing). Crucially, we emphasized automatic motion-induced anticipatory processes by rendering the motion stimuli non-predictive of upcoming target position (by design) and task-irrelevant (by instruction), and by creating instead endogenous (orthogonal) expectations using symbolic cueing. Our data revealed that the apparent motion cues automatically engaged both spatial and temporal anticipatory processes, but that these processes were dissociated. We further found evidence for lateralisation of anticipatory temporal but not spatial processes. This indicates that distinct mechanisms may drive automatic spatial and temporal extrapolation of upcoming events from rhythmic event streams. This contrasts with previous findings that instead suggest an interaction between spatial and temporal attention processes when endogenously driven. Our results further highlight the need for isolating intentional from unintentional processes for better understanding the various anticipatory mechanisms engaged in processing behaviourally relevant stimuli with predictable spatio-temporal structure such as motion and speech. PMID:26623650

Gamma-ray emission from internal shocks in novae

NASA Astrophysics Data System (ADS)

Martin, P.; Dubus, G.; Jean, P.; Tatischeff, V.; Dosne, C.

2018-04-01

problem are degenerate and/or poorly constrained except for the wind velocity, the relatively low values of which result in the majority of best-fit models having gamma-ray spectra with a high-energy turnover below 10 GeV. Our typical model is able to account for the main features in the observations of the recent gamma-ray nova ASASSN-16ma. Conclusions: The internal shock model can account for the gamma-ray emission of the novae detected by Fermi LAT. Gamma-ray observations hold potential for probing the mechanism of mass ejection in novae, but should be combined to diagnostics of the thermal emission at lower energies to be more constraining.

MCNPX evaluation of gamma spectrometry results in high radon concentration areas.

PubMed

Thinová, L; Solc, J

2014-07-01

The radon concentration in underground workplaces may reach tens of thousands of Bq m(-3). A simple MCNPXTM Monte Carlo (MC) model of a cave was developed to estimate the influence of radon on the in situ gamma spectrometry results in various geometries and radon concentrations. The detector total count rate was obtained as the sum of the individual count rates due to 214Bi in the air, radon in the walls and deposition of radon daughters on surfaces. The MC model was then modified and used in the natural conditions of the Mladeč Caves, Czech Republic. The content of 226Ra was calculated from laboratory gamma spectrometry measurements, and the concentrations of unattached and attached 214Bi were measured using the FRITRA4 device (SMM-Prague). We present a comparison of the experimental results with results calculated by the MCNPXTM model of the Gamma Surveyor spectrometry probe (GF Instruments) with a 3″×3″ NaI(Tl) detector and a 2″×2″ BGO detector. © The Author 2014. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Features in the spectra of gamma-ray bursts

NASA Technical Reports Server (NTRS)

Stanek, Krzysztof Z.; Paczynski, Bohdan; Goodman, Jeremy

1993-01-01

Gravitational lensing of cosmological gamma-ray bursts by objects in the mass range about 10 exp 17 to 10 exp 20 g (femtolensing) may introduce complicated interference patterns that might be interpreted as absorption or emission lines in the bursts' spectra. This phenomenon, if detected, may be used as a unique probe of dark matter in the universe. The BATSE spectral data should allow one to detect such spectral features or to put significant upper limits on the cosmic density of a dark matter component that may be in the femtolensing range. Software to generate theoretical spectra has been developed, and it is accessible over the computer network with anonymous ftp.

Toward structural elucidation of the gamma-secretase complex

DOE Office of Scientific and Technical Information (OSTI.GOV)

Li, H.; Wolfe, M. S.; Selkoe, D. J.

2009-03-11

{gamma}-Secretase is an intramembrane protease complex that mediates the Notch signaling pathway and the production of amyloid {beta}-proteins. As such, this enzyme has emerged as an important target for development of novel therapeutics for Alzheimer disease and cancer. Great progress has been made in the identification and characterization of the membrane complex and its biological functions. One major challenge now is to illuminate the structure of this fascinating and important protease at atomic resolution. Here, we review recent progress on biochemical and biophysical probing of the structure of the four-component complex and discuss obstacles and potential pathways toward elucidating itsmore » detailed structure.« less

Analysis of early dengue virus infection in mice as modulated by Aedes aegypti probing.

PubMed

McCracken, M K; Christofferson, R C; Chisenhall, D M; Mores, C N

2014-02-01

Dengue virus (DENV), the etiologic agent of dengue fever, is transmitted during probing of human skin by infected-mosquito bite. The expectorated viral inoculum also contains an assortment of mosquito salivary proteins that have been shown to modulate host hemostasis and innate immune responses. To examine the potential role of mosquito probing in DENV establishment within the vertebrate host, we inoculated mice intradermally with DENV serotype 2 strain 1232 at sites where Aedes aegypti had or had not probed immediately prior. We assayed these sites 3 h postinoculation with transcript arrays for the Toll-like receptor (TLR), RIG-I-like receptor, and NOD-like receptor signaling pathways of the innate immune system. We then chose TLR7, transcription factor p65 (RelA), gamma interferon (IFN-γ), and IFN-γ-inducible protein 10 (IP-10) from the arrays for further investigation and assayed these transcripts at 10 min, 3 h, and 6 h postinoculation. The transcripts for TLR7, RelA, IFN-γ, and IP-10 were significantly downregulated between 2- and 3-fold in the group subjected to mosquito probing relative to the virus-only inoculation group at 3 h postinoculation. A reduction in these transcripts could indicate reduced DENV recognition and antigen presentation and diminished inhibition of viral replication and spread. Further, mosquito probing resulted in viremia titers significantly higher than those in mice that did not receive probing. A. aegypti probing has a significant effect on the innate immune response to DENV infection and generates an early immune environment more permissive to the establishment of infection.

Probe measurements and numerical model predictions of evolving size distributions in premixed flames

DOE Office of Scientific and Technical Information (OSTI.GOV)

De Filippo, A.; Sgro, L.A.; Lanzuolo, G.

2009-09-15

Particle size distributions (PSDs), measured with a dilution probe and a Differential Mobility Analyzer (DMA), and numerical predictions of these PSDs, based on a model that includes only coagulation or alternatively inception and coagulation, are compared to investigate particle growth processes and possible sampling artifacts in the post-flame region of a C/O = 0.65 premixed laminar ethylene-air flame. Inputs to the numerical model are the PSD measured early in the flame (the initial condition for the aerosol population) and the temperature profile measured along the flame's axial centerline. The measured PSDs are initially unimodal, with a modal mobility diameter ofmore » 2.2 nm, and become bimodal later in the post-flame region. The smaller mode is best predicted with a size-dependent coagulation model, which allows some fraction of the smallest particles to escape collisions without resulting in coalescence or coagulation through the size-dependent coagulation efficiency ({gamma}{sub SD}). Instead, when {gamma} = 1 and the coagulation rate is equal to the collision rate for all particles regardless of their size, the coagulation model significantly under predicts the number concentration of both modes and over predicts the size of the largest particles in the distribution compared to the measured size distributions at various heights above the burner. The coagulation ({gamma}{sub SD}) model alone is unable to reproduce well the larger particle mode (mode II). Combining persistent nucleation with size-dependent coagulation brings the predicted PSDs to within experimental error of the measurements, which seems to suggest that surface growth processes are relatively insignificant in these flames. Shifting measured PSDs a few mm closer to the burner surface, generally adopted to correct for probe perturbations, does not produce a better matching between the experimental and the numerical results. (author)« less

Precision imaging of 4.4 MeV gamma rays using a 3-D position sensitive Compton camera.

PubMed

Koide, Ayako; Kataoka, Jun; Masuda, Takamitsu; Mochizuki, Saku; Taya, Takanori; Sueoka, Koki; Tagawa, Leo; Fujieda, Kazuya; Maruhashi, Takuya; Kurihara, Takuya; Inaniwa, Taku

2018-05-25

Imaging of nuclear gamma-ray lines in the 1-10 MeV range is far from being established in both medical and physical applications. In proton therapy, 4.4 MeV gamma rays are emitted from the excited nucleus of either 12 C* or 11 B* and are considered good indicators of dose delivery and/or range verification. Further, in gamma-ray astronomy, 4.4 MeV gamma rays are produced by cosmic ray interactions in the interstellar medium, and can thus be used to probe nucleothynthesis in the universe. In this paper, we present a high-precision image of 4.4 MeV gamma rays taken by newly developed 3-D position sensitive Compton camera (3D-PSCC). To mimic the situation in proton therapy, we first irradiated water, PMMA and Ca(OH)2 with a 70 MeV proton beam, then we identified various nuclear lines with the HPGe detector. The 4.4 MeV gamma rays constitute a broad peak, including single and double escape peaks. Thus, by setting an energy window of 3D-PSCC from 3 to 5 MeV, we show that a gamma ray image sharply concentrates near the Bragg peak, as expected from the minimum energy threshold and sharp peak profile in the cross section of 12 C(p,p) 12 C*.

Very high-energy gamma rays from gamma-ray bursts.

PubMed

Chadwick, Paula M

2007-05-15

Very high-energy (VHE) gamma-ray astronomy has undergone a transformation in the last few years, with telescopes of unprecedented sensitivity having greatly expanded the source catalogue. Such progress makes the detection of a gamma-ray burst at the highest energies much more likely than previously. This paper describes the facilities currently operating and their chances for detecting gamma-ray bursts, and reviews predictions for VHE gamma-ray emission from gamma-ray bursts. Results to date are summarized.

Straight trajectory planning for keyhole neurosurgery in sheep with automatic brain structures segmentation

NASA Astrophysics Data System (ADS)

Favaro, Alberto; Lad, Akash; Formenti, Davide; Zani, Davide Danilo; De Momi, Elena

2017-03-01

In a translational neuroscience/neurosurgery perspective, sheep are considered good candidates to study because of the similarity between their brain and the human one. Automatic planning systems for safe keyhole neurosurgery maximize the probe/catheter distance from vessels and risky structures. This work consists in the development of a trajectories planner for straight catheters placement intended to be used for investigating the drug diffusivity mechanisms in sheep brain. Automatic brain segmentation of gray matter, white matter and cerebrospinal fluid is achieved using an online available sheep atlas. Ventricles, midbrain and cerebellum segmentation have been also carried out. The veterinary surgeon is asked to select a target point within the white matter to be reached by the probe and to define an entry area on the brain cortex. To mitigate the risk of hemorrhage during the insertion process, which can prevent the success of the insertion procedure, the trajectory planner performs a curvature analysis of the brain cortex and wipes out from the poll of possible entry points the sulci, as part of brain cortex where superficial blood vessels are naturally located. A limited set of trajectories is then computed and presented to the surgeon, satisfying an optimality criteria based on a cost function which considers the distance from critical brain areas and the whole trajectory length. The planner proved to be effective in defining rectilinear trajectories accounting for the safety constraints determined by the brain morphology. It also demonstrated a short computational time and good capability in segmenting gyri and sulci surfaces.

Rat embryo cells immortalized with transfected oncogenes are transformed by gamma irradiation.

PubMed

Endlich, B; Salavati, R; Sullivan, T; Ling, C C

1992-12-01

of myc, raf, Ha-ras, or Ki-ras genes in any REC:myc transformant. DNA from several transformed REC:myc:gamma cell lines induced focus formation in recipient C3H 10T1/2 and NIH 3T3 cells. The NIH 3T3 foci tested positive when hybridized to a probe for rat repetitive DNA. A detailed analysis of the NIH 3T3 transformants generated from REC:myc:gamma 33 and gamma 41 DNA failed to detect Ha-ras, Ki-ras, raf, neu, trk, abl, fms, or src oncogenes of rat origin.(ABSTRACT TRUNCATED AT 400 WORDS)

A new gamma ray imaging diagnostic for runaway electron studies at DIII-D

NASA Astrophysics Data System (ADS)

Cooper, C. M.; Pace, D. C.; Eidietis, N. W.; Paz-Soldan, C.; Commaux, N.; Shiraki, D.; Hollmann, E. M.; Moyer, R. A.; Risov, V.

2015-11-01

A new Gamma Ray Imager (GRI) is developed to probe the electron distribution function with 2D spatial resolution during runaway electron (RE) experiments at DIII-D. The diagnostic is sensitive to 0.5 - 50 MeV gamma rays, allowing characterization of the RE distribution function evolution during RE dissipation from pellet injection. The GRI consists of a lead ``pinhole camera'' mounted on the midplane with 11x11 counter-current tangential chords 20 cm wide that span the vessel. Up to 30 bismuth germanate (BGO) scintillation detectors capture RE Bremsstrahlung radiation. Detectors operate in current saturation mode at 10 MHz, or the flux is attenuated for Pulse Height Analysis (PHA) capable of discriminating up to ~10k pulses per second. Digital signal processing routines combining shaping filters are performed during PHA to reject noise and record gamma ray energy. The GRI setup and PHA algorithms will be described and initial data from experiments will be presented. Work supported by the US DOE under DE-AC05-00OR22725, DE-FG02-07ER54917 & DE-FC02-04ER54698.

Huygens Probe In-Situ Measurements : An Update

NASA Astrophysics Data System (ADS)

Lorenz, Ralph D.

2015-04-01

The global Titan perspective afforded by ongoing Cassini observations, and prospects for future in-situ exploration, have prompted a re-examination of Huygens data, yielding a number of recent new results. Gravity waves have been detected (Lorenz, Ferri and Young, Icarus, 2014) in the HASI descent temperature data, with ~2K amplitude. These waves are seen above about 60km, and analysis suggests they may therefore be controlled by interaction of upward-propagating waves with the zonal wind field. A curious cessation of detection of sound pulses by a Surface Science Package ultrasound instrument about 15 minutes after the probe landed appears to be best explained (Lorenz et al., Planetary and Space Science, 2014) by an accumulation of polyatomic vapors such as ethane, sweated out of the ground by the warm probe. Such gases have high acoustic attenuation, and were independently measured by the probe GCMS. The Huygens probe carried two radar altimeters. While their principal function was merely to trigger observation sequences at specific altitudes on the science instruments, the surface range history, and the Automatic Gain Control (AGC) housekeeping data, provide some useful information on Titan's surface (Lorenz et al., submitted). Small-scale topographic variations, and the surface radar reflectivity characteristics implied by the AGC variation with height, are discussed. A new integrated timeline product, which arranges second-by-second measurements from several Huygens sensors on a convenient, common tabulation, has been recently archived on the PDS Atmospheres node. Finally, a troubling discrepancy exists between radio occultation and infrared soundings from Cassini, and Huygens methane and temperature measurements in the lower stratosphere. The interdependence of these parameters will be discussed. In particular the possible role of the assumed probe mass history (depending on the unmeasured ablation from the heat shield) and the assumed zonal wind profile on

Statistical Measurement of the Gamma-Ray Source-count Distribution as a Function of Energy

NASA Astrophysics Data System (ADS)

Zechlin, Hannes-S.; Cuoco, Alessandro; Donato, Fiorenza; Fornengo, Nicolao; Regis, Marco

2016-08-01

Statistical properties of photon count maps have recently been proven as a new tool to study the composition of the gamma-ray sky with high precision. We employ the 1-point probability distribution function of six years of Fermi-LAT data to measure the source-count distribution dN/dS and the diffuse components of the high-latitude gamma-ray sky as a function of energy. To that aim, we analyze the gamma-ray emission in five adjacent energy bands between 1 and 171 GeV. It is demonstrated that the source-count distribution as a function of flux is compatible with a broken power law up to energies of ˜50 GeV. The index below the break is between 1.95 and 2.0. For higher energies, a simple power-law fits the data, with an index of {2.2}-0.3+0.7 in the energy band between 50 and 171 GeV. Upper limits on further possible breaks as well as the angular power of unresolved sources are derived. We find that point-source populations probed by this method can explain {83}-13+7% ({81}-19+52%) of the extragalactic gamma-ray background between 1.04 and 1.99 GeV (50 and 171 GeV). The method has excellent capabilities for constraining the gamma-ray luminosity function and the spectra of unresolved blazars.

Monte Carlo modeling of ultrasound probes for image guided radiotherapy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bazalova-Carter, Magdalena, E-mail: bazalova@uvic.ca; Schlosser, Jeffrey; Chen, Josephine

2015-10-15

Purpose: To build Monte Carlo (MC) models of two ultrasound (US) probes and to quantify the effect of beam attenuation due to the US probes for radiation therapy delivered under real-time US image guidance. Methods: MC models of two Philips US probes, an X6-1 matrix-array transducer and a C5-2 curved-array transducer, were built based on their megavoltage (MV) CT images acquired in a Tomotherapy machine with a 3.5 MV beam in the EGSnrc, BEAMnrc, and DOSXYZnrc codes. Mass densities in the probes were assigned based on an electron density calibration phantom consisting of cylinders with mass densities between 0.2 andmore » 8.0 g/cm{sup 3}. Beam attenuation due to the US probes in horizontal (for both probes) and vertical (for the X6-1 probe) orientation was measured in a solid water phantom for 6 and 15 MV (15 × 15) cm{sup 2} beams with a 2D ionization chamber array and radiographic films at 5 cm depth. The MC models of the US probes were validated by comparison of the measured dose distributions and dose distributions predicted by MC. Attenuation of depth dose in the (15 × 15) cm{sup 2} beams and small circular beams due to the presence of the probes was assessed by means of MC simulations. Results: The 3.5 MV CT number to mass density calibration curve was found to be linear with R{sup 2} > 0.99. The maximum mass densities in the X6-1 and C5-2 probes were found to be 4.8 and 5.2 g/cm{sup 3}, respectively. Dose profile differences between MC simulations and measurements of less than 3% for US probes in horizontal orientation were found, with the exception of the penumbra region. The largest 6% dose difference was observed in dose profiles of the X6-1 probe placed in vertical orientation, which was attributed to inadequate modeling of the probe cable. Gamma analysis of the simulated and measured doses showed that over 96% of measurement points passed the 3%/3 mm criteria for both probes placed in horizontal orientation and for the X6-1 probe in vertical

The automatic component of habit in health behavior: habit as cue-contingent automaticity.

PubMed

Orbell, Sheina; Verplanken, Bas

2010-07-01

Habit might be usefully characterized as a form of automaticity that involves the association of a cue and a response. Three studies examined habitual automaticity in regard to different aspects of the cue-response relationship characteristic of unhealthy and healthy habits. In each study, habitual automaticity was assessed by the Self-Report Habit Index (SRHI). In Study 1 SRHI scores correlated with attentional bias to smoking cues in a Stroop task. Study 2 examined the ability of a habit cue to elicit an unwanted habit response. In a prospective field study, habitual automaticity in relation to smoking when drinking alcohol in a licensed public house (pub) predicted the likelihood of cigarette-related action slips 2 months later after smoking in pubs had become illegal. In Study 3 experimental group participants formed an implementation intention to floss in response to a specified situational cue. Habitual automaticity of dental flossing was rapidly enhanced compared to controls. The studies provided three different demonstrations of the importance of cues in the automatic operation of habits. Habitual automaticity assessed by the SRHI captured aspects of a habit that go beyond mere frequency or consistency of the behavior. PsycINFO Database Record (c) 2010 APA, all rights reserved.

The Advanced Gamma-ray Imaging System (AGIS): Galactic Astrophysics

NASA Astrophysics Data System (ADS)

Digel, Seth William; Funk, S.; Kaaret, P. E.; Tajima, H.; AGIS Collaboration

2010-03-01

The Advanced Gamma-ray Imaging System (AGIS), a concept for a next-generation atmospheric Cherenkov telescope array, would provide unprecedented sensitivity and resolution in the energy range >50 GeV, allowing great advances in the understanding of the populations and physics of sources of high-energy gamma rays in the Milky Way. Extrapolation based on the known source classes and the performance parameters for AGIS indicates that a survey of the Galactic plane with AGIS will reveal hundreds of TeV sources in exquisite detail, for population studies of a variety of source classes, and detailed studies of individual sources. AGIS will be able to study propagation effects on the cosmic rays produced by Galactic sources by detecting the diffuse glow from their interactions in dense interstellar gas. AGIS will complement and extend results now being obtained in the GeV range with the Fermi mission, by providing superior angular resolution and sensitivity to variability on short time scales, and of course by probing energies that Fermi cannot reach.

Is Transducer Hygiene sufficient when Vaginal Probes are used in the Clinical Routine?

PubMed

Merz, E

2016-04-01

special virucidal wipes on the probes is considered low-level disinfection. Primarily quaternary ammonia compounds are employed for this procedure. This method is easily applicable, has good cleaning characteristics, is effective against HPV and has high skin tolerance. However, it has the disadvantage of not removing all microorganisms during the disinfection process. Immersion procedures are high-level disinfection methods during which the transducer head is dipped in a special fluid for a certain amount of time. The disinfectants used for this include e. g. preparations based on glutaraldehyde or succinic aldehyde. However, in practice immersion disinfection has a number of disadvantages 13: 1. The procedure cannot be validated. 2. The probe permanently attached to the device must be placed in a separate holder and disinfected for at least 15 minutes. This is impracticable in routine operations in a clinic, outpatient facility or practice with a high number of examinations. 3. After this disinfection method, the probe has to be thoroughly rinsed with potable or higher-quality water in order to remove remnants of allergenic or locally toxic substances. 4. Frequently examinations take place in small interior areas with poor ventilation, thus under some circumstances posing an inhalant-related health hazard. 5. The required virucidal effect is frequently not achieved within 15 minutes 13. Furthermore, extended probe contact with liquid disinfecting agents in the long run results in increased wear of the transducer head membrane.Therefore it was interesting to note that in 2009 a fully-automatic disinfection system for ultrasound probes was introduced to the market (Trophon(EPR). This product, developed in Australia, promised relatively rapid high-level disinfection (HLD). During this software-controlled, mechanical disinfection procedure, the entire ultrasound probe (transducer head and handle) is placed in a sealed disinfection chamber, then hydrogen peroxide (H2O2) is

Drift-insensitive distributed calibration of probe microscope scanner in nanometer range: Virtual mode

NASA Astrophysics Data System (ADS)

Lapshin, Rostislav V.

2016-08-01

A method of distributed calibration of a probe microscope scanner is suggested. The main idea consists in a search for a net of local calibration coefficients (LCCs) in the process of automatic measurement of a standard surface, whereby each point of the movement space of the scanner can be characterized by a unique set of scale factors. Feature-oriented scanning (FOS) methodology is used as a basis for implementation of the distributed calibration permitting to exclude in situ the negative influence of thermal drift, creep and hysteresis on the obtained results. Possessing the calibration database enables correcting in one procedure all the spatial systematic distortions caused by nonlinearity, nonorthogonality and spurious crosstalk couplings of the microscope scanner piezomanipulators. To provide high precision of spatial measurements in nanometer range, the calibration is carried out using natural standards - constants of crystal lattice. One of the useful modes of the developed calibration method is a virtual mode. In the virtual mode, instead of measurement of a real surface of the standard, the calibration program makes a surface image ;measurement; of the standard, which was obtained earlier using conventional raster scanning. The application of the virtual mode permits simulation of the calibration process and detail analysis of raster distortions occurring in both conventional and counter surface scanning. Moreover, the mode allows to estimate the thermal drift and the creep velocities acting while surface scanning. Virtual calibration makes possible automatic characterization of a surface by the method of scanning probe microscopy (SPM).

Spectrophotometric probe

DOEpatents

Prather, W.S.; O'Rourke, P.E.

1994-08-02

A support structure is described bearing at least one probe for making spectrophotometric measurements of a fluid using a source of light and a spectrophotometer. The probe includes a housing with two optical fibers and a planoconvex lens. A sleeve bearing a mirror surrounds the housing. The lens is separated from the mirror by a fixed distance, defining an interior space for receiving a volume of the fluid sample. A plurality of throughholes extending through the sleeve communicate between the sample volume and the exterior of the probe, all but one hole bearing a screen. A protective jacket surrounds the probe. A hollow conduit bearing a tube is formed in the wall of the probe for venting any air in the interior space when fluid enters. The probe is held at an acute angle so the optic fibers carrying the light to and from the probe are not bent severely on emergence from the probe. 3 figs.

Spectrophotometric probe

DOEpatents

Prather, William S.; O'Rourke, Patrick E.

1994-01-01

A support structure bearing at least one probe for making spectrophotometric measurements of a fluid using a source of light and a spectrophotometer. The probe includes a housing with two optical fibers and a planoconvex lens. A sleeve bearing a mirror surrounds the housing. The lens is separated from the mirror by a fixed distance, defining an interior space for receiving a volume of the fluid sample. A plurality of throughholes extending through the sleeve communicate between the sample volume and the exterior of the probe, all but one hole bearing a screen. A protective jacket surrounds the probe. A hollow conduit bearing a tube is formed in the wall of the probe for venting any air in the interior space when fluid enters. The probe is held at an acute angle so the optic fibers carrying the light to and from the probe are not bent severely on emergence from the probe.

Automatic and controlled attentional orienting in the elderly: A dual-process view of the positivity effect.

PubMed

Gronchi, G; Righi, S; Pierguidi, L; Giovannelli, F; Murasecco, I; Viggiano, M P

2018-04-01

The positivity effect in the elderly consists of an attentional preference for positive information as well as avoidance of negative information. Extant theories predict either that the positivity effect depends on controlled attentional processes (socio-emotional selectivity theory), or on an automatic gating selection mechanism (dynamic integration theory). This study examined the role of automatic and controlled attention in the positivity effect. Two dot-probe tasks (with the duration of the stimuli lasting 100 ms and 500 ms, respectively) were employed to compare the attentional bias of 35 elderly people to that of 35 young adults. The stimuli used were expressive faces displaying neutral, disgusted, fearful, and happy expressions. In comparison to young people, the elderly allocated more attention to happy faces at 100 ms and they tended to avoid fearful faces at 500 ms. The findings are not predicted by either theory taken alone, but support the hypothesis that the positivity effect in the elderly is driven by two different processes: an automatic attention bias toward positive stimuli, and a controlled mechanism that diverts attention away from negative stimuli. Copyright © 2018 Elsevier B.V. All rights reserved.

Partial nephrectomy using radiofrequency incremental bipolar generator with multi electrode probe: experimental study in bench pig kidneys

PubMed Central

2014-01-01

Background The aim of this research project was the realization of an incremental bipolar radiofrequency generator with inline 4-electrode probe for partial renal resection without clamping of the vessels. Methods The experimentation was carried out across two phases: the preliminary realization of a specific generator and an inline multielectrode probe for open surgery (Phase 1); system testing on 27 bench kidneys for a total of 47 partial resection (Phase 2). The parameters evaluated were: power level, generator automatisms, parenchymal coagulation times, needle caliber, thickness of the coagulated tissue “slice”, charring, ergonomy, feasibility of the application of “bolster” stitches. Results The analysis of the results referred to the homogeneity and thickness of coagulation, energy supply times with reference to the power level and caliber of the needles. The optimal results were obtained by using needles of 1.5 mm caliber at power level 5, and with coagulation times of 54 seconds for the first insertion and 30 seconds for the second. Conclusions The experimentation demonstrated that the apparatus, consisting of a generator named “LaparoNewPro” and fitted with a dedicated probe for open surgery, is able to carry out a coagulation of the line of resection of the renal parenchyma in a homogeneous manner, in short times, without tissue charring, and with the possibility of stitching both on coagulated tissue and the caliceal system. The generator automatism based on the flow of the current supplied by each electrode is reliable, and the cessation of energy supply coincides with optimal coagulation. PMID:24410789

Probing stochastic inter-galactic magnetic fields using blazar-induced gamma ray halo morphology

NASA Astrophysics Data System (ADS)

Duplessis, Francis; Vachaspati, Tanmay

2017-05-01

Inter-galactic magnetic fields can imprint their structure on the morphology of blazar-induced gamma ray halos. We show that the halo morphology arises through the interplay of the source's jet and a two-dimensional surface dictated by the magnetic field. Through extensive numerical simulations, we generate mock halos created by stochastic magnetic fields with and without helicity, and study the dependence of the halo features on the properties of the magnetic field. We propose a sharper version of the Q-statistics and demonstrate its sensitivity to the magnetic field strength, the coherence scale, and the handedness of the helicity. We also identify and explain a new feature of the Q-statistics that can further enhance its power.

A Search for WW$$\\gamma$$ and WZ$$\\gamma$$ Triboson Production and Anomalous Quartic Gauge Couplings at $$\\sqrt{s}$$ = 8 and 13~TeV within the Compact Muon Solenoid

DOE Office of Scientific and Technical Information (OSTI.GOV)

Faulkner, James

2016-01-01

An analysis probing for the standard model production of three electroweak vector bosons, WVmore » $$\\gamma$$ with V = W or Z gauge boson, is presented. The W boson decays leptonically to an electron or muon, or their respective antiparticle, paired with the appropriate neutrino. The second boson V decays hadronically into two jets, and additionally a photon is required in the event. The data analyzed correspond to an integrated luminosity of 19.6~fb$$^{-1}$$ and 2.3~fb$$^{-1}$$ from proton-proton collisions at $$\\sqrt{s}$$ = 8~TeV and 13~TeV, respectively, collected in 2012 and 2015 by the CMS detector at the Large Hadron Collider. The event selection criteria used in these analyses yields 322 and 46 observed events in data in 2012 and 2015, respectively, while the estimated background yield from theoretical predictions is 342.1~$$\\pm$$~22.2 and 54.3~$$\\pm$$~17.7. These observations are consistent with the standard model next-to-leading order QCD predictions. Given the limitation in statistics to measure the cross section for this production process, an upper limit of 3.4 times the standard model predictions is made at a 95\\% confidence level for WV$$\\gamma$$ with photon $$p_{T}$$ greater than 30~GeV and absolute pseudorapidity less than 1.44. Physics beyond the standard model, such as anomalous couplings between the gauge bosons at the quartic vertex, may lead to enhancement in the number of WV$$\\gamma$$ events produced within high energy collisions. Such enhancements can be observed in kinematic distributions, particularly in the higher energy regions. No evidence of anomalous WW$$\\gamma\\gamma$$ and WWZ$$\\gamma$$ quartic gauge boson couplings is found, while 95\\% confidence level upper limits are obtained for various couplings.« less

Pioneer Jupiter orbiter probe mission 1980, probe description

NASA Technical Reports Server (NTRS)

Defrees, R. E.

1974-01-01

The adaptation of the Saturn-Uranus Atmospheric Entry Probe (SUAEP) to a Jupiter entry probe is summarized. This report is extracted from a comprehensive study of Jovian missions, atmospheric model definitions and probe subsystem alternatives.

Automatic localization of the da Vinci surgical instrument tips in 3-D transrectal ultrasound.

PubMed

Mohareri, Omid; Ramezani, Mahdi; Adebar, Troy K; Abolmaesumi, Purang; Salcudean, Septimiu E

2013-09-01

Robot-assisted laparoscopic radical prostatectomy (RALRP) using the da Vinci surgical system is the current state-of-the-art treatment option for clinically confined prostate cancer. Given the limited field of view of the surgical site in RALRP, several groups have proposed the integration of transrectal ultrasound (TRUS) imaging in the surgical workflow to assist with accurate resection of the prostate and the sparing of the neurovascular bundles (NVBs). We previously introduced a robotic TRUS manipulator and a method for automatically tracking da Vinci surgical instruments with the TRUS imaging plane, in order to facilitate the integration of intraoperative TRUS in RALRP. Rapid and automatic registration of the kinematic frames of the da Vinci surgical system and the robotic TRUS probe manipulator is a critical component of the instrument tracking system. In this paper, we propose a fully automatic registration technique based on automatic 3-D TRUS localization of robot instrument tips pressed against the air-tissue boundary anterior to the prostate. The detection approach uses a multiscale filtering technique to identify and localize surgical instrument tips in the TRUS volume, and could also be used to detect other surface fiducials in 3-D ultrasound. Experiments have been performed using a tissue phantom and two ex vivo tissue samples to show the feasibility of the proposed methods. Also, an initial in vivo evaluation of the system has been carried out on a live anaesthetized dog with a da Vinci Si surgical system and a target registration error (defined as the root mean square distance of corresponding points after registration) of 2.68 mm has been achieved. Results show this method's accuracy and consistency for automatic registration of TRUS images to the da Vinci surgical system.

TU-H-CAMPUS-TeP3-04: Probing the Dose Enhancement Due to a Clinically-Relevant Concentration of Gold Nanoparticles and Yb-169 Gamma Rays Using PRESAGE Dosimeters

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cho, J; Oklahoma State University, Stillwater, OK; Alqathami, M

Purpose: To probe physical evidences of the dose enhancement due to a low/clinically-relevant concentration of gold nanoparticles (GNPs) and Yb-169 gamma rays using PRESAGE dosimeters. Methods: A PRESAGE cuvette was placed at approximately 2 mm above the plane containing three novel Yb-169 brachytherapy seeds (3.2, 3.2, and 5.3 mCi each). Two types of PRESAGE dosimeters were used – plain PRESAGEs (controls) and PRESAGEs loaded with 0.02 wt. % of GNPs (GNP-PRESAGEs). Each PRESAGE dosimeter was irradiated with different time durations (0 to 24 hours) to deliver 0, 4, 8, 16 and 24 Gy of dose. For a reference/comparison, both typesmore » of PRESAGEs were also irradiated using 250 kVp x-rays with/without Er-filter to deliver 0, 3, 10, and 30 Gy of dose. Er-filter was used to emulate Yb-169 spectrum using 250 kVp x-rays. The absorption spectra of PRESAGEs were measured using a UV spectrophotometer and used to determine the corresponding optical densities (ODs). Results: GNP-PRESAGEs exposed to Yb-169 sources showed ∼65% increase in ODs compared with controls. When exposed to Er-filtered and unfiltered 250 kVp x-rays, they produced smaller increases in ODs, ∼41% and ∼37%, respectively. There was a linear relationship between ODs and delivered doses with a goodness-of-fit (R2) greater than 0.99. Conclusion: A notable increase in the ODs (∼65%) was observed for GNP-PRESAGEs irradiated by Yb-169 gamma rays. Considering the observed OD increases, it was highly likely that Yb-169 gamma rays were more effective than both Er-filtered and unfiltered 250 kVp x-rays, in terms of producing the dose enhancement. Due to several unknown factors (e.g., possible difference in the dose response of GNP-PRESAGEs vs. PRESAGEs), however, a further investigations is necessary to establish the feasibility of quantifying the exact amount of macroscopic or microscopic/local GNP-mediated dose enhancement using PRESAGE or similar volumetric dosimeters. Supported by DOD/PCRP grant W81XWH

Search for long-lived gravitational-wave transients coincident with long gamma-ray bursts

NASA Astrophysics Data System (ADS)

Aasi, J.; Abadie, J.; Abbott, B. P.; Abbott, R.; Abbott, T.; Abernathy, M. R.; Accadia, T.; Acernese, F.; Adams, C.; Adams, T.; Adhikari, R. X.; Affeldt, C.; Agathos, M.; Aggarwal, N.; Aguiar, O. D.; Ajith, P.; Allen, B.; Allocca, A.; Amador Ceron, E.; Amariutei, D.; Anderson, R. A.; Anderson, S. B.; Anderson, W. G.; Arai, K.; Araya, M. C.; Arceneaux, C.; Areeda, J.; Ast, S.; Aston, S. M.; Astone, P.; Aufmuth, P.; Aulbert, C.; Austin, L.; Aylott, B. E.; Babak, S.; Baker, P. T.; Ballardin, G.; Ballmer, S. W.; Barayoga, J. C.; Barker, D.; Barnum, S. H.; Barone, F.; Barr, B.; Barsotti, L.; Barsuglia, M.; Barton, M. A.; Bartos, I.; Bassiri, R.; Basti, A.; Batch, J.; Bauchrowitz, J.; Bauer, Th. S.; Bebronne, M.; Behnke, B.; Bejger, M.; Beker, M. G.; Bell, A. S.; Bell, C.; Belopolski, I.; Bergmann, G.; Berliner, J. M.; Bersanetti, D.; Bertolini, A.; Bessis, D.; Betzwieser, J.; Beyersdorf, P. T.; Bhadbhade, T.; Bilenko, I. A.; Billingsley, G.; Birch, J.; Bitossi, M.; Bizouard, M. A.; Black, E.; Blackburn, J. K.; Blackburn, L.; Blair, D.; Blom, M.; Bock, O.; Bodiya, T. P.; Boer, M.; Bogan, C.; Bond, C.; Bondu, F.; Bonelli, L.; Bonnand, R.; Bork, R.; Born, M.; Boschi, V.; Bose, S.; Bosi, L.; Bowers, J.; Bradaschia, C.; Brady, P. R.; Braginsky, V. B.; Branchesi, M.; Brannen, C. A.; Brau, J. E.; Breyer, J.; Briant, T.; Bridges, D. O.; Brillet, A.; Brinkmann, M.; Brisson, V.; Britzger, M.; Brooks, A. F.; Brown, D. A.; Brown, D. D.; Brückner, F.; Bulik, T.; Bulten, H. J.; Buonanno, A.; Buskulic, D.; Buy, C.; Byer, R. L.; Cadonati, L.; Cagnoli, G.; Calderón Bustillo, J.; Calloni, E.; Camp, J. B.; Campsie, P.; Cannon, K. C.; Canuel, B.; Cao, J.; Capano, C. D.; Carbognani, F.; Carbone, L.; Caride, S.; Castiglia, A.; Caudill, S.; Cavaglià, M.; Cavalier, F.; Cavalieri, R.; Cella, G.; Cepeda, C.; Cesarini, E.; Chakraborty, R.; Chalermsongsak, T.; Chao, S.; Charlton, P.; Chassande-Mottin, E.; Chen, X.; Chen, Y.; Chincarini, A.; Chiummo, A.; Cho, H. S.; Chow, J.; Christensen, N.; Chu, Q.; Chua, S. S. Y.; Chung, S.; Ciani, G.; Clara, F.; Clark, D. E.; Clark, J. A.; Cleva, F.; Coccia, E.; Cohadon, P.-F.; Colla, A.; Colombini, M.; Constancio, M., Jr.; Conte, A.; Conte, R.; Cook, D.; Corbitt, T. R.; Cordier, M.; Cornish, N.; Corsi, A.; Costa, C. A.; Coughlin, M. W.; Coulon, J.-P.; Countryman, S.; Couvares, P.; Coward, D. M.; Cowart, M.; Coyne, D. C.; Craig, K.; Creighton, J. D. E.; Creighton, T. D.; Crowder, S. G.; Cumming, A.; Cunningham, L.; Cuoco, E.; Dahl, K.; Dal Canton, T.; Damjanic, M.; Danilishin, S. L.; D'Antonio, S.; Danzmann, K.; Dattilo, V.; Daudert, B.; Daveloza, H.; Davier, M.; Davies, G. S.; Daw, E. J.; Day, R.; Dayanga, T.; De Rosa, R.; Debreczeni, G.; Degallaix, J.; Del Pozzo, W.; Deleeuw, E.; Deléglise, S.; Denker, T.; Dent, T.; Dereli, H.; Dergachev, V.; DeRosa, R.; DeSalvo, R.; Dhurandhar, S.; Di Fiore, L.; Di Lieto, A.; Di Palma, I.; Di Virgilio, A.; Díaz, M.; Dietz, A.; Dmitry, K.; Donovan, F.; Dooley, K. L.; Doravari, S.; Drago, M.; Drever, R. W. P.; Driggers, J. C.; Du, Z.; Dumas, J.-C.; Dwyer, S.; Eberle, T.; Edwards, M.; Effler, A.; Ehrens, P.; Eichholz, J.; Eikenberry, S. S.; Endrőczi, G.; Essick, R.; Etzel, T.; Evans, K.; Evans, M.; Evans, T.; Factourovich, M.; Fafone, V.; Fairhurst, S.; Fang, Q.; Farinon, S.; Farr, B.; Farr, W.; Favata, M.; Fazi, D.; Fehrmann, H.; Feldbaum, D.; Ferrante, I.; Ferrini, F.; Fidecaro, F.; Finn, L. S.; Fiori, I.; Fisher, R.; Flaminio, R.; Foley, E.; Foley, S.; Forsi, E.; Fotopoulos, N.; Fournier, J.-D.; Franco, S.; Frasca, S.; Frasconi, F.; Frede, M.; Frei, M.; Frei, Z.; Freise, A.; Frey, R.; Fricke, T. T.; Fritschel, P.; Frolov, V. V.; Fujimoto, M.-K.; Fulda, P.; Fyffe, M.; Gair, J.; Gammaitoni, L.; Garcia, J.; Garufi, F.; Gehrels, N.; Gemme, G.; Genin, E.; Gennai, A.; Gergely, L.; Ghosh, S.; Giaime, J. A.; Giampanis, S.; Giardina, K. D.; Giazotto, A.; Gil-Casanova, S.; Gill, C.; Gleason, J.; Goetz, E.; Goetz, R.; Gondan, L.; González, G.; Gordon, N.; Gorodetsky, M. L.; Gossan, S.; Goßler, S.; Gouaty, R.; Graef, C.; Graff, P. B.; Granata, M.; Grant, A.; Gras, S.; Gray, C.; Greenhalgh, R. J. S.; Gretarsson, A. M.; Griffo, C.; Groot, P.; Grote, H.; Grover, K.; Grunewald, S.; Guidi, G. M.; Guido, C.; Gushwa, K. E.; Gustafson, E. K.; Gustafson, R.; Hall, B.; Hall, E.; Hammer, D.; Hammond, G.; Hanke, M.; Hanks, J.; Hanna, C.; Hanson, J.; Harms, J.; Harry, G. M.; Harry, I. W.; Harstad, E. D.; Hartman, M. T.; Haughian, K.; Hayama, K.; Heefner, J.; Heidmann, A.; Heintze, M.; Heitmann, H.; Hello, P.; Hemming, G.; Hendry, M.; Heng, I. S.; Heptonstall, A. W.; Heurs, M.; Hild, S.; Hoak, D.; Hodge, K. A.; Holt, K.; Holtrop, M.; Hong, T.; Hooper, S.; Horrom, T.; Hosken, D. J.; Hough, J.; Howell, E. J.; Hu, Y.; Hua, Z.; Huang, V.; Huerta, E. A.; Hughey, B.; Husa, S.; Huttner, S. H.; Huynh, M.; Huynh-Dinh, T.; Iafrate, J.; Ingram, D. R.; Inta, R.; Isogai, T.; Ivanov, A.; Iyer, B. R.; Izumi, K.; Jacobson, M.; James, E.; Jang, H.; Jang, Y. J.; Jaranowski, P.; Jiménez-Forteza, F.; Johnson, W. W.; Jones, D.; Jones, D. I.; Jones, R.; Jonker, R. J. G.; Ju, L.; Haris, K.; Kalmus, P.; Kalogera, V.; Kandhasamy, S.; Kang, G.; Kanner, J. B.; Kasprzack, M.; Kasturi, R.; Katsavounidis, E.; Katzman, W.; Kaufer, H.; Kaufman, K.; Kawabe, K.; Kawamura, S.; Kawazoe, F.; Kéfélian, F.; Keitel, D.; Kelley, D. B.; Kells, W.; Keppel, D. G.; Khalaidovski, A.; Khalili, F. Y.; Khazanov, E. A.; Kim, B. K.; Kim, C.; Kim, K.; Kim, N.; Kim, W.; Kim, Y.-M.; King, E. J.; King, P. J.; Kinzel, D. L.; Kissel, J. S.; Klimenko, S.; Kline, J.; Koehlenbeck, S.; Kokeyama, K.; Kondrashov, V.; Koranda, S.; Korth, W. Z.; Kowalska, I.; Kozak, D.; Kremin, A.; Kringel, V.; Królak, A.; Kucharczyk, C.; Kudla, S.; Kuehn, G.; Kumar, A.; Kumar, P.; Kumar, R.; Kurdyumov, R.; Kwee, P.; Landry, M.; Lantz, B.; Larson, S.; Lasky, P. D.; Lawrie, C.; Lazzarini, A.; Le Roux, A.; Leaci, P.; Lebigot, E. O.; Lee, C.-H.; Lee, H. K.; Lee, H. M.; Lee, J.; Lee, J.; Leonardi, M.; Leong, J. R.; Leroy, N.; Letendre, N.; Levine, B.; Lewis, J. B.; Lhuillier, V.; Li, T. G. F.; Lin, A. C.; Littenberg, T. B.; Litvine, V.; Liu, F.; Liu, H.; Liu, Y.; Liu, Z.; Lloyd, D.; Lockerbie, N. A.; Lockett, V.; Lodhia, D.; Loew, K.; Logue, J.; Lombardi, A. L.; Lorenzini, M.; Loriette, V.; Lormand, M.; Losurdo, G.; Lough, J.; Luan, J.; Lubinski, M. J.; Lück, H.; Lundgren, A. P.; Macarthur, J.; Macdonald, E.; Machenschalk, B.; MacInnis, M.; Macleod, D. M.; Magana-Sandoval, F.; Mageswaran, M.; Mailand, K.; Majorana, E.; Maksimovic, I.; Malvezzi, V.; Man, N.; Manca, G. M.; Mandel, I.; Mandic, V.; Mangano, V.; Mantovani, M.; Marchesoni, F.; Marion, F.; Márka, S.; Márka, Z.; Markosyan, A.; Maros, E.; Marque, J.; Martelli, F.; Martin, I. W.; Martin, R. M.; Martinelli, L.; Martynov, D.; Marx, J. N.; Mason, K.; Masserot, A.; Massinger, T. J.; Matichard, F.; Matone, L.; Matzner, R. A.; Mavalvala, N.; May, G.; Mazumder, N.; Mazzolo, G.; McCarthy, R.; McClelland, D. E.; McGuire, S. C.; McIntyre, G.; McIver, J.; Meacher, D.; Meadors, G. D.; Mehmet, M.; Meidam, J.; Meier, T.; Melatos, A.; Mendell, G.; Mercer, R. A.; Meshkov, S.; Messenger, C.; Meyer, M. S.; Miao, H.; Michel, C.; Mikhailov, E. E.; Milano, L.; Miller, J.; Minenkov, Y.; Mingarelli, C. M. F.; Mitra, S.; Mitrofanov, V. P.; Mitselmakher, G.; Mittleman, R.; Moe, B.; Mohan, M.; Mohapatra, S. R. P.; Mokler, F.; Moraru, D.; Moreno, G.; Morgado, N.; Mori, T.; Morriss, S. R.; Mossavi, K.; Mours, B.; Mow-Lowry, C. M.; Mueller, C. L.; Mueller, G.; Mukherjee, S.; Mullavey, A.; Munch, J.; Murphy, D.; Murray, P. G.; Mytidis, A.; Nagy, M. F.; Nanda Kumar, D.; Nardecchia, I.; Nash, T.; Naticchioni, L.; Nayak, R.; Necula, V.; Nelemans, G.; Neri, I.; Neri, M.; Newton, G.; Nguyen, T.; Nishida, E.; Nishizawa, A.; Nitz, A.; Nocera, F.; Nolting, D.; Normandin, M. E.; Nuttall, L. K.; Ochsner, E.; O'Dell, J.; Oelker, E.; Ogin, G. H.; Oh, J. J.; Oh, S. H.; Ohme, F.; Oppermann, P.; O'Reilly, B.; Ortega Larcher, W.; O'Shaughnessy, R.; Osthelder, C.; Ott, C. D.; Ottaway, D. J.; Ottens, R. S.; Ou, J.; Overmier, H.; Owen, B. J.; Padilla, C.; Pai, A.; Palomba, C.; Pan, Y.; Pankow, C.; Paoletti, F.; Paoletti, R.; Papa, M. A.; Paris, H.; Pasqualetti, A.; Passaquieti, R.; Passuello, D.; Pedraza, M.; Peiris, P.; Penn, S.; Perreca, A.; Phelps, M.; Pichot, M.; Pickenpack, M.; Piergiovanni, F.; Pierro, V.; Pinard, L.; Pindor, B.; Pinto, I. M.; Pitkin, M.; Poeld, J.; Poggiani, R.; Poole, V.; Poux, C.; Predoi, V.; Prestegard, T.; Price, L. R.; Prijatelj, M.; Principe, M.; Privitera, S.; Prodi, G. A.; Prokhorov, L.; Puncken, O.; Punturo, M.; Puppo, P.; Quetschke, V.; Quintero, E.; Quitzow-James, R.; Raab, F. J.; Rabeling, D. S.; Rácz, I.; Radkins, H.; Raffai, P.; Raja, S.; Rajalakshmi, G.; Rakhmanov, M.; Ramet, C.; Rapagnani, P.; Raymond, V.; Re, V.; Reed, C. M.; Reed, T.; Regimbau, T.; Reid, S.; Reitze, D. H.; Ricci, F.; Riesen, R.; Riles, K.; Robertson, N. A.; Robinet, F.; Rocchi, A.; Roddy, S.; Rodriguez, C.; Rodruck, M.; Roever, C.; Rolland, L.; Rollins, J. G.; Romano, J. D.; Romano, R.; Romanov, G.; Romie, J. H.; Rosińska, D.; Rowan, S.; Rüdiger, A.; Ruggi, P.; Ryan, K.; Salemi, F.; Sammut, L.; Sandberg, V.; Sanders, J.; Sannibale, V.; Santiago-Prieto, I.; Saracco, E.; Sassolas, B.; Sathyaprakash, B. S.; Saulson, P. R.; Savage, R.; Schilling, R.; Schnabel, R.; Schofield, R. M. S.; Schreiber, E.; Schuette, D.; Schulz, B.; Schutz, B. F.; Schwinberg, P.; Scott, J.; Scott, S. M.; Seifert, F.; Sellers, D.; Sengupta, A. S.; Sentenac, D.; Sergeev, A.; Shaddock, D.; Shah, S.; Shahriar, M. S.; Shaltev, M.; Shapiro, B.; Shawhan, P.; Shoemaker, D. H.; Sidery, T. L.; Siellez, K.; Siemens, X.; Sigg, D.; Simakov, D.; Singer, A.; Singer, L.; Sintes, A. M.; Skelton, G. R.; Slagmolen, B. J. J.; Slutsky, J.; Smith, J. R.; Smith, M. R.; Smith, R. J. E.; Smith-Lefebvre, N. D.; Soden, K.; Son, E. J.; Sorazu, B.; Souradeep, T.; Sperandio, L.; Staley, A.; Steinert, E.; Steinlechner, J.; Steinlechner, S.; Steplewski, S.; Stevens, D.; Stochino, A.; Stone, R.; Strain, K. A.; Straniero, N.; Strigin, S.; Stroeer, A. S.; Sturani, R.; Stuver, A. L.; Summerscales, T. Z.; Susmithan, S.; Sutton, P. J.; Swinkels, B.; Szeifert, G.; Tacca, M.; Talukder, D.; Tang, L.; Tanner, D. B.; Tarabrin, S. P.; Taylor, R.; ter Braack, A. P. M.; Thirugnanasambandam, M. P.; Thomas, M.; Thomas, P.; Thorne, K. A.; Thorne, K. S.; Thrane, E.; Tiwari, V.; Tokmakov, K. V.; Tomlinson, C.; Toncelli, A.; Tonelli, M.; Torre, O.; Torres, C. V.; Torrie, C. I.; Travasso, F.; Traylor, G.; Tse, M.; Ugolini, D.; Unnikrishnan, C. S.; Vahlbruch, H.; Vajente, G.; Vallisneri, M.; van den Brand, J. F. J.; Van Den Broeck, C.; van der Putten, S.; van der Sluys, M. V.; van Heijningen, J.; van Veggel, A. A.; Vass, S.; Vasúth, M.; Vaulin, R.; Vecchio, A.; Vedovato, G.; Veitch, J.; Veitch, P. J.; Venkateswara, K.; Verkindt, D.; Verma, S.; Vetrano, F.; Viceré, A.; Vincent-Finley, R.; Vinet, J.-Y.; Vitale, S.; Vlcek, B.; Vo, T.; Vocca, H.; Vorvick, C.; Vousden, W. D.; Vrinceanu, D.; Vyachanin, S. P.; Wade, A.; Wade, L.; Wade, M.; Waldman, S. J.; Walker, M.; Wallace, L.; Wan, Y.; Wang, J.; Wang, M.; Wang, X.; Wanner, A.; Ward, R. L.; Was, M.; Weaver, B.; Wei, L.-W.; Weinert, M.; Weinstein, A. J.; Weiss, R.; Welborn, T.; Wen, L.; Wessels, P.; West, M.; Westphal, T.; Wette, K.; Whelan, J. T.; Whitcomb, S. E.; White, D. J.; Whiting, B. F.; Wibowo, S.; Wiesner, K.; Wilkinson, C.; Williams, L.; Williams, R.; Williams, T.; Willis, J. L.; Willke, B.; Wimmer, M.; Winkelmann, L.; Winkler, W.; Wipf, C. C.; Wittel, H.; Woan, G.; Worden, J.; Yablon, J.; Yakushin, I.; Yamamoto, H.; Yancey, C. C.; Yang, H.; Yeaton-Massey, D.; Yoshida, S.; Yum, H.; Yvert, M.; Zadrożny, A.; Zanolin, M.; Zendri, J.-P.; Zhang, F.; Zhang, L.; Zhao, C.; Zhu, H.; Zhu, X. J.; Zotov, N.; Zucker, M. E.; Zweizig, J.

2013-12-01

Long gamma-ray bursts (GRBs) have been linked to extreme core-collapse supernovae from massive stars. Gravitational waves (GW) offer a probe of the physics behind long GRBs. We investigate models of long-lived (˜10-1000s) GW emission associated with the accretion disk of a collapsed star or with its protoneutron star remnant. Using data from LIGO’s fifth science run, and GRB triggers from the Swift experiment, we perform a search for unmodeled long-lived GW transients. Finding no evidence of GW emission, we place 90% confidence-level upper limits on the GW fluence at Earth from long GRBs for three waveforms inspired by a model of GWs from accretion disk instabilities. These limits range from F<3.5ergscm-2 to F<1200ergscm-2, depending on the GRB and on the model, allowing us to probe optimistic scenarios of GW production out to distances as far as ≈33Mpc. Advanced detectors are expected to achieve strain sensitivities 10× better than initial LIGO, potentially allowing us to probe the engines of the nearest long GRBs.

Submicrosecond phospholipid dynamics using a long-lived fluorescence emission anisotropy probe.

PubMed Central

Davenport, L; Targowski, P

1996-01-01

The use of the long-lived fluorescence probe coronene (mean value of tau(FL) approximately 200 ns) is described for investigating submicrosecond lipid dynamics in DPPC model bilayer systems occurring below the lipid phase transition. Time-resolved fluorescence emission anisotropy decay profiles, measures as a function of increasing temperature toward the lipid-phase transition temperature (T(C)), for coronene-labeled DPPC small unilamellar vesicles (SUVs), are best described in most cases by three rotational decay components (phi(i = 3)). We have interpreted these data using two dynamic lipid bilayer models. In the first, a compartmental model, the long correlation time (phi(N)) is assigned to immobilized coronene molecules located in "gel-like" or highly ordered lipid phases (S-->1) of the bilayer, whereas a second fast rotational time (phi(F) approximately 2-5 ns) is associated with probes residing in more "fluid-like" regions (with corresponding lower ordering, S-->0). Interests here have focused on the origins of an intermediate correlation time (50-100 ns), the associated amplitude (beta(G)) of which increases with increasing temperature. Such behavior suggests a changing rotational environment surrounding the coronene molecules, arising from fluidization of gel lipid. The observed effective correlation time (phi(EFF)) thus reflects a discrete gel-fluid lipid exchange rate (k(FG)). A refinement of the compartmental model invokes a distribution of gel-fluid exchange rates (d(S,T)) corresponding to a distribution of lipid order parameters and is based on an adapted Landau expression for describing "gated" packing fluctuations. A total of seven parameters (five thermodynamic quantities, defined by the free energy versus temperature expansion; one gating parameter (gamma) defining a cooperative "melting" requirement; one limiting diffusion rate (or frequency factor: d(infinity))) suffice to predict complete anisotropy decay curves measured for coronene at several

Gamma-sky.net: Portal to the gamma-ray sky

NASA Astrophysics Data System (ADS)

Voruganti, Arjun; Deil, Christoph; Donath, Axel; King, Johannes

2017-01-01

http://gamma-sky.net is a novel interactive website designed for exploring the gamma-ray sky. The Map View portion of the site is powered by the Aladin Lite sky atlas, providing a scalable survey image tesselated onto a three-dimensional sphere. The map allows for interactive pan and zoom navigation as well as search queries by sky position or object name. The default image overlay shows the gamma-ray sky observed by the Fermi-LAT gamma-ray space telescope. Other survey images (e.g. Planck microwave images in low/high frequency bands, ROSAT X-ray image) are available for comparison with the gamma-ray data. Sources from major gamma-ray source catalogs of interest (Fermi-LAT 2FHL, 3FGL and a TeV source catalog) are overlaid over the sky map as markers. Clicking on a given source shows basic information in a popup, and detailed pages for every source are available via the Catalog View component of the website, including information such as source classification, spectrum and light-curve plots, and literature references. We intend for gamma-sky.net to be applicable for both professional astronomers as well as the general public. The website started in early June 2016 and is being developed as an open-source, open data project on GitHub (https://github.com/gammapy/gamma-sky). We plan to extend it to display more gamma-ray and multi-wavelength data. Feedback and contributions are very welcome!

A portable cadmium telluride multidetector probe for cardiac function monitoring

NASA Astrophysics Data System (ADS)

Arntz, Y.; Chambron, J.; Dumitresco, B.; Eclancher, B.; Prat, V.

1999-06-01

A new nuclear stethoscope based on a matrix of small CdTe semiconductor detectors has been developed for studying the cardiac performance by gamma ventriculography at the equilibrium, in rest and stress conditions, in the early and recovery phases of the coronary disease and to follow the long-term therapy. The light-weight probe consists of an array of 64 detectors 5×5×2 mm grouped in 16 independent units in a lead shielded aluminum box including 16 preamplifiers. The probe is connected to an electronic box containing DC power supply, 16 channel amplifiers, discriminators and counters, two analog-triggering ECG channels, and interface to a PC. The left ventricle activity is, preferentially, detected by using a low-resolution matching convergent collimator. A physical evaluation of the probe has been performed, both with static tests and dynamically with a hydraulic home-built model of beating heart ventricle paced by a rhythm simulator. The sum of the 16 detectors activity provided a radiocardiogram (RCG) which well depicted the filling and ejection of the cardiac beats, allowing to compare the clinically relevant parameters of the cardiac performance, proportional variables of the stroke volume (SV), ejection fraction (EF) and ventricular flow-rate with the known absolute values programmed on the model. The portable system is now in operation for clinical assessment of cardiac patients.

Broadband observations of the naked-eye gamma-ray burst GRB 080319B.

PubMed

Racusin, J L; Karpov, S V; Sokolowski, M; Granot, J; Wu, X F; Pal'shin, V; Covino, S; van der Horst, A J; Oates, S R; Schady, P; Smith, R J; Cummings, J; Starling, R L C; Piotrowski, L W; Zhang, B; Evans, P A; Holland, S T; Malek, K; Page, M T; Vetere, L; Margutti, R; Guidorzi, C; Kamble, A P; Curran, P A; Beardmore, A; Kouveliotou, C; Mankiewicz, L; Melandri, A; O'Brien, P T; Page, K L; Piran, T; Tanvir, N R; Wrochna, G; Aptekar, R L; Barthelmy, S; Bartolini, C; Beskin, G M; Bondar, S; Bremer, M; Campana, S; Castro-Tirado, A; Cucchiara, A; Cwiok, M; D'Avanzo, P; D'Elia, V; Valle, M Della; de Ugarte Postigo, A; Dominik, W; Falcone, A; Fiore, F; Fox, D B; Frederiks, D D; Fruchter, A S; Fugazza, D; Garrett, M A; Gehrels, N; Golenetskii, S; Gomboc, A; Gorosabel, J; Greco, G; Guarnieri, A; Immler, S; Jelinek, M; Kasprowicz, G; La Parola, V; Levan, A J; Mangano, V; Mazets, E P; Molinari, E; Moretti, A; Nawrocki, K; Oleynik, P P; Osborne, J P; Pagani, C; Pandey, S B; Paragi, Z; Perri, M; Piccioni, A; Ramirez-Ruiz, E; Roming, P W A; Steele, I A; Strom, R G; Testa, V; Tosti, G; Ulanov, M V; Wiersema, K; Wijers, R A M J; Winters, J M; Zarnecki, A F; Zerbi, F; Mészáros, P; Chincarini, G; Burrows, D N

2008-09-11

Long-duration gamma-ray bursts (GRBs) release copious amounts of energy across the entire electromagnetic spectrum, and so provide a window into the process of black hole formation from the collapse of massive stars. Previous early optical observations of even the most exceptional GRBs (990123 and 030329) lacked both the temporal resolution to probe the optical flash in detail and the accuracy needed to trace the transition from the prompt emission within the outflow to external shocks caused by interaction with the progenitor environment. Here we report observations of the extraordinarily bright prompt optical and gamma-ray emission of GRB 080319B that provide diagnostics within seconds of its formation, followed by broadband observations of the afterglow decay that continued for weeks. We show that the prompt emission stems from a single physical region, implying an extremely relativistic outflow that propagates within the narrow inner core of a two-component jet.

Mutant quantity and quality in mammalian cells (AL) exposed to cesium-137 gamma radiation: effect of caffeine

NASA Technical Reports Server (NTRS)

McGuinness, S. M.; Shibuya, M. L.; Ueno, A. M.; Vannais, D. B.; Waldren, C. A.; Chatterjee, A. (Principal Investigator)

1995-01-01

We examined the effect of caffeine (1,3,7-trimethylxanthine) on the quantity and quality of mutations in cultured mammalian AL human-hamster hybrid cells exposed to 137Cs gamma radiation. At a dose (1.5 mg/ml for 16 h) that reduced the plating efficiency (PE) by 20%, caffeine was not itself a significant mutagen, but it increased by approximately twofold the slope of the dose-response curve for induction of S1- mutants by 137Cs gamma radiation. Molecular analysis of 235 S1- mutants using a series of DNA probes mapped to the human chromosome 11 in the AL hybrid cells revealed that 73 to 85% of the mutations in unexposed cells and in cells treated with caffeine alone, 137Cs gamma rays alone or 137Cs gamma rays plus caffeine were large deletions involving millions of base pairs of DNA. Most of these deletions were contiguous with the region of the MIC1 gene at 11p13 that encodes the S1 cell surface antigen. In other mutants that had suffered multiple marker loss, the deletions were intermittent along chromosome 11. These "complex" mutations were rare for 137Cs gamma irradiation (1/63 = 1.5%) but relatively prevalent (23-50%) for other exposure conditions. Thus caffeine appears to alter both the quantity and quality of mutations induced by 137Cs gamma irradiation.

SU-E-T-213: Comparison of Treatment Efficiency of Gamma Knife SRS Plans for Brain Metastases with Different Planning Methods

DOE Office of Scientific and Technical Information (OSTI.GOV)

Feng, Y; Huang, Z; Lo, S

2015-06-15

Purpose: To improve Gamma Knife SRS treatment efficiency for brain metastases and compare the differences of treatment time and radiobiological effects between two different planning methods of automatic filling and manual placement of shots with inverse planning. Methods: T1-weighted MRI images with gadolinium contrast from five patients with a single brain metastatic-lesion were used in this retrospective study. Among them, two were from primary breast cancer, two from primary melanoma cancer and one from primary prostate cancer. For each patient, two plans were generated in Leksell GammaPlan10.1.1 for radiosurgical treatment with a Leksell GammaKnife Perfexion machine: one with automatic filling,more » automatic sector configuration and inverse optimization (Method1); and the other with manual placement of shots, manual setup of collimator sizes, manual setup of sector blocking and inverse optimization (Method2). Dosimetric quality of the plans was evaluated with parameters of Coverage, Selectivity, Gradient-Index and DVH. Beam-on Time, Number-of-Shots and Tumor Control Probability(TCP) were compared for the two plans while keeping their dosimetric quality very similar. Relative reduction of Beam-on Time and Number-of-Shots were calculated as the ratios among the two plans and used for quantitative analysis. Results: With very similar dosimetric and radiobiological plan quality, plans created with Method 2 had significantly reduced treatment time. Relative reduction of Beam-on Time ranged from 20% to 51 % (median:29%,p=0.001), and reduction of Number-of-Shots ranged from 5% to 67% (median:40%,p=0.0002), respectively. Time of plan creation for Method1 and Method2 was similar, approximately 20 minutes, excluding the time for tumor delineation. TCP calculated for the tumors from differential DVHs did not show significant difference between the two plans (p=0.35). Conclusion: The method of manual setup combined with inverse optimization in LGP for treatment of

Motor automaticity in Parkinson’s disease

PubMed Central

Wu, Tao; Hallett, Mark; Chan, Piu

2017-01-01

Bradykinesia is the most important feature contributing to motor difficulties in Parkinson’s disease (PD). However, the pathophysiology underlying bradykinesia is not fully understood. One important aspect is that PD patients have difficulty in performing learned motor skills automatically, but this problem has been generally overlooked. Here we review motor automaticity associated motor deficits in PD, such as reduced arm swing, decreased stride length, freezing of gait, micrographia and reduced facial expression. Recent neuroimaging studies have revealed some neural mechanisms underlying impaired motor automaticity in PD, including less efficient neural coding of movement, failure to shift automated motor skills to the sensorimotor striatum, instability of the automatic mode within the striatum, and use of attentional control and/or compensatory efforts to execute movements usually performed automatically in healthy people. PD patients lose previously acquired automatic skills due to their impaired sensorimotor striatum, and have difficulty in acquiring new automatic skills or restoring lost motor skills. More investigations on the pathophysiology of motor automaticity, the effect of L-dopa or surgical treatments on automaticity, and the potential role of using measures of automaticity in early diagnosis of PD would be valuable. PMID:26102020

The SWIFT Gamma-Ray Burst X-Ray Telescope

NASA Technical Reports Server (NTRS)

Hill, J. E.; Burrows, D. N.; Nousek, J. A.; Wells, A.; Chincarini, G.; Abbey, A. F.; Angelini, L.; Beardmore, A.; Brauninger, H. W.; Chang, W.

2006-01-01

The Swift Gamma-Ray Burst Explorer is designed to make prompt multi-wavelength observations of Gamma-Ray Bursts and GRB afterglows. The X-ray Telescope enables Swift to determine GRB positions with a few arcseconds accuracy within 100 seconds of the burst onset. The XRT utilizes a mirror set built for JET-X and an XMM-Newton/ EPIC MOS CCD detector to provide a sensitive broad-band (0.2-10 keV) X-ray imager with an effective area of more than 120 sq cm at 1.5 keV, a field of view of 23.6 x 23.6 arcminutes, and an angular resolution of 18 arcseconds (HPD). The detection sensitivity is 2x10(exp 14) erg/sq cm/s in 10(exp 4) seconds. The instrument provides automated source detection and position reporting within 5 seconds of target acquisition. It can also measure the redshifts of GRBs with Iron line emission or other spectral features. The XRT operates in an auto-exposure mode, adjusting the CCD readout mode automatically to optimize the science return as the source intensity fades. The XRT measures spectra and lightcurves of the GRB afterglow beginning about a minute after the burst and follows each burst for days or weeks. We provide an overview of the X-ray Telescope scientific background from which the systems engineering requirements were derived, with specific emphasis on the design and qualification aspects from conception through to launch. We describe the impact on cleanliness and vacuum requirements for the instrument low energy response and to maintain the high sensitivity to the fading signal of the Gamma-ray Bursts.

Probing stochastic inter-galactic magnetic fields using blazar-induced gamma ray halo morphology

DOE Office of Scientific and Technical Information (OSTI.GOV)

Duplessis, Francis; Vachaspati, Tanmay, E-mail: fdupless@asu.edu, E-mail: tvachasp@asu.edu

Inter-galactic magnetic fields can imprint their structure on the morphology of blazar-induced gamma ray halos. We show that the halo morphology arises through the interplay of the source's jet and a two-dimensional surface dictated by the magnetic field. Through extensive numerical simulations, we generate mock halos created by stochastic magnetic fields with and without helicity, and study the dependence of the halo features on the properties of the magnetic field. We propose a sharper version of the Q-statistics and demonstrate its sensitivity to the magnetic field strength, the coherence scale, and the handedness of the helicity. We also identify andmore » explain a new feature of the Q-statistics that can further enhance its power.« less

Statistical measurement of the gamma-ray source-count distribution as a function of energy

DOE PAGES

Zechlin, Hannes-S.; Cuoco, Alessandro; Donato, Fiorenza; ...

2016-07-29

Statistical properties of photon count maps have recently been proven as a new tool to study the composition of the gamma-ray sky with high precision. Here, we employ the 1-point probability distribution function of six years of Fermi-LAT data to measure the source-count distribution dN/dS and the diffuse components of the high-latitude gamma-ray sky as a function of energy. To that aim, we analyze the gamma-ray emission in five adjacent energy bands between 1 and 171 GeV. It is demonstrated that the source-count distribution as a function of flux is compatible with a broken power law up to energies of ~50 GeV. Furthermore, the index below the break is between 1.95 and 2.0. For higher energies, a simple power-law fits the data, with an index ofmore » $${2.2}_{-0.3}^{+0.7}$$ in the energy band between 50 and 171 GeV. Upper limits on further possible breaks as well as the angular power of unresolved sources are derived. We find that point-source populations probed by this method can explain $${83}_{-13}^{+7}$$% ($${81}_{-19}^{+52}$$%) of the extragalactic gamma-ray background between 1.04 and 1.99 GeV (50 and 171 GeV). Our method has excellent capabilities for constraining the gamma-ray luminosity function and the spectra of unresolved blazars.« less

Statistical measurement of the gamma-ray source-count distribution as a function of energy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zechlin, Hannes-S.; Cuoco, Alessandro; Donato, Fiorenza

Statistical properties of photon count maps have recently been proven as a new tool to study the composition of the gamma-ray sky with high precision. Here, we employ the 1-point probability distribution function of six years of Fermi-LAT data to measure the source-count distribution dN/dS and the diffuse components of the high-latitude gamma-ray sky as a function of energy. To that aim, we analyze the gamma-ray emission in five adjacent energy bands between 1 and 171 GeV. It is demonstrated that the source-count distribution as a function of flux is compatible with a broken power law up to energies of ~50 GeV. Furthermore, the index below the break is between 1.95 and 2.0. For higher energies, a simple power-law fits the data, with an index ofmore » $${2.2}_{-0.3}^{+0.7}$$ in the energy band between 50 and 171 GeV. Upper limits on further possible breaks as well as the angular power of unresolved sources are derived. We find that point-source populations probed by this method can explain $${83}_{-13}^{+7}$$% ($${81}_{-19}^{+52}$$%) of the extragalactic gamma-ray background between 1.04 and 1.99 GeV (50 and 171 GeV). Our method has excellent capabilities for constraining the gamma-ray luminosity function and the spectra of unresolved blazars.« less

Time-resolved Neutron-gamma-ray Data Acquisition for in Situ Subsurface Planetary Geochemistry

NASA Technical Reports Server (NTRS)

Bodnarik, Julie G.; Burger, Dan Michael; Burger, A.; Evans, L. G.; Parsons, A. M.; Schweitzer, J. S.; Starr R. D.; Stassun, K. G.

2013-01-01

The current gamma-ray/neutron instrumentation development effort at NASA Goddard Space Flight Center aims to extend the use of active pulsed neutron interrogation techniques to probe the subsurface elemental composition of planetary bodies in situ. Previous NASA planetary science missions, that used neutron and/or gamma-ray spectroscopy instruments, have relied on neutrons produced from galactic cosmic rays. One of the distinguishing features of this effort is the inclusion of a high intensity 14.1 MeV pulsed neutron generator synchronized with a custom data acquisition system to time each event relative to the pulse. With usually only one opportunity to collect data, it is difficult to set a priori time-gating windows to obtain the best possible results. Acquiring time-tagged, event-by-event data from nuclear induced reactions provides raw data sets containing channel/energy, and event time for each gamma ray or neutron detected. The resulting data set can be plotted as a function of time or energy using optimized analysis windows after the data are acquired. Time windows can now be chosen to produce energy spectra that yield the most statistically significant and accurate elemental composition results that can be derived from the complete data set. The advantages of post-processing gamma-ray time-tagged event-by-event data in experimental tests using our prototype instrument will be demonstrated.

Resonance production in. gamma gamma. collisions

DOE Office of Scientific and Technical Information (OSTI.GOV)

Renard, F.M.

1983-04-01

The processes ..gamma gamma.. ..-->.. hadrons can be depicted as follows. One photon creates a q anti q pair which starts to evolve; the other photon can either (A) make its own q anti q pair and the (q anti q q anti q) system continue to evolve or (B) interact with the quarks of the first pair and lead to a modified (q anti q) system in interaction with C = +1 quantum numbers. A review of the recent theoretical activity concerning resonance production and related problems is given under the following headings: hadronic C = +1 spectroscopy (qmore » anti q, qq anti q anti q, q anti q g, gg, ggg bound states and mixing effects); exclusive ..gamma gamma.. processes (generalities, unitarized Born method, VDM and QCD); total cross section (soft and hard contributions); q/sup 2/ dependence of soft processes (soft/hard separation, 1/sup +- +/ resonances); and polarization effects. (WHK)« less

Probing dark matter annihilation in the Galaxy with antiprotons and gamma rays

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cuoco, Alessandro; Heisig, Jan; Korsmeier, Michael

2017-10-01

A possible hint of dark matter annihilation has been found in Cuoco, Korsmeier and Krämer (2017) from an analysis of recent cosmic-ray antiproton data from AMS-02 and taking into account cosmic-ray propagation uncertainties by fitting at the same time dark matter and propagation parameters. Here, we extend this analysis to a wider class of annihilation channels. We find consistent hints of a dark matter signal with an annihilation cross-section close to the thermal value and with masses in range between 40 and 130 GeV depending on the annihilation channel. Furthermore, we investigate in how far the possible signal is compatiblemore » with the Galactic center gamma-ray excess and recent observation of dwarf satellite galaxies by performing a joint global fit including uncertainties in the dark matter density profile. As an example, we interpret our results in the framework of the Higgs portal model.« less

Pharmacological evidences for DFK167-sensitive presenilin-independent gamma-secretase-like activity.

PubMed

Sevalle, Jean; Ayral, Erwan; Hernandez, Jean-François; Martinez, Jean; Checler, Frédéric

2009-07-01

Amyloid-beta (Abeta) peptides production is thought to be a key event in the neurodegenerative process ultimately leading to Alzheimer's disease (AD) pathology. A bulk of studies concur to propose that the C-terminal moiety of Abeta is released from its precursor beta-amyloid precursor protein by a high molecular weight enzymatic complex referred to as gamma-secretase, that is composed of at least, nicastrin (NCT), Aph-1, Pen-2, and presenilins (PS) 1 or 2. They are thought to harbor the gamma-secretase catalytic activity. However, several lines of evidence suggest that additional gamma-secretase-like activities could potentially contribute to Abeta production. By means of a quenched fluorimetric substrate (JMV2660) mimicking the beta-amyloid precursor protein sequence targeted by gamma-secretase, we first show that as expected, this probe allows monitoring of an activity detectable in several cell systems including the neuronal cell line telencephalon specific murine neurons (TSM1). This activity is reduced by DFK167, N-[N-(3,5-difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester (DAPT), and LY68458, three inhibitors known to functionally interact with PS. Interestingly, JMV2660 but not the unrelated peptide JMV2692, inhibits Abeta production in an in vitrogamma-secretase assay as expected from a putative substrate competitor. This activity is enhanced by PS1 and PS2 mutations known to be responsible for familial forms of AD and reduced by aspartyl mutations inactivating PS or in cells devoid of PS or NCT. However, we clearly establish that residual JMV2660-hydrolysing activity could be recovered in PS- and NCT-deficient fibroblasts and that this activity remained inhibited by DFK167. Overall, our study describes the presence of a proteolytic activity displaying gamma-secretase-like properties but independent of PS and still blocked by DFK167, suggesting that the PS-dependent complex could not be the unique gamma-secretase activity responsible for Abeta

Hydrodynamic ultrasonic probe

DOEpatents

Day, Robert A.; Conti, Armond E.

1980-01-01

An improved probe for in-service ultrasonic inspection of long lengths of a workpiece, such as small diameter tubing from the interior. The improved probe utilizes a conventional transducer or transducers configured to inspect the tubing for flaws and/or wall thickness variations. The probe utilizes a hydraulic technique, in place of the conventional mechanical guides or bushings, which allows the probe to move rectilinearly or rotationally while preventing cocking thereof in the tube and provides damping vibration of the probe. The probe thus has lower friction and higher inspection speed than presently known probes.

Automatic imitation: A meta-analysis.

PubMed

Cracco, Emiel; Bardi, Lara; Desmet, Charlotte; Genschow, Oliver; Rigoni, Davide; De Coster, Lize; Radkova, Ina; Deschrijver, Eliane; Brass, Marcel

2018-05-01

Automatic imitation is the finding that movement execution is facilitated by compatible and impeded by incompatible observed movements. In the past 15 years, automatic imitation has been studied to understand the relation between perception and action in social interaction. Although research on this topic started in cognitive science, interest quickly spread to related disciplines such as social psychology, clinical psychology, and neuroscience. However, important theoretical questions have remained unanswered. Therefore, in the present meta-analysis, we evaluated seven key questions on automatic imitation. The results, based on 161 studies containing 226 experiments, revealed an overall effect size of g z = 0.95, 95% CI [0.88, 1.02]. Moderator analyses identified automatic imitation as a flexible, largely automatic process that is driven by movement and effector compatibility, but is also influenced by spatial compatibility. Automatic imitation was found to be stronger for forced choice tasks than for simple response tasks, for human agents than for nonhuman agents, and for goalless actions than for goal-directed actions. However, it was not modulated by more subtle factors such as animacy beliefs, motion profiles, or visual perspective. Finally, there was no evidence for a relation between automatic imitation and either empathy or autism. Among other things, these findings point toward actor-imitator similarity as a crucial modulator of automatic imitation and challenge the view that imitative tendencies are an indicator of social functioning. The current meta-analysis has important theoretical implications and sheds light on longstanding controversies in the literature on automatic imitation and related domains. (PsycINFO Database Record (c) 2018 APA, all rights reserved).

Long-Lag, Wide-pulse Gamma-Ray Bursts

NASA Technical Reports Server (NTRS)

Norris, J. P.; Bonnell, J. T.; Kazanas, D.; Scargle, . D.; Hakkila, J.; Giblin, T. W.

2004-01-01

Currently, the best available probe of the early phase of gamma-ray burst (GRB) jet attributes is the prompt gamma-ray emission, in which several intrinsic and extrinsic variables determine GRB pulse evolution. Bright, usually complex bursts have many narrow pulses that are difficult to model due to overlap. However, the relatively simple, long spectral lag, wide-pulse bursts may have simpler physics and are easier to model. In this work we analyze the temporal and spectral behavior of wide pulses in 24 long-lag bursts, using a pulse model with two shape parameters - width and asymmetry - and the Band spectral model with three shape parameters. We find that pulses in long-lag bursts are distinguished both temporally and spectrally from those in bright bursts: the pulses in long spectral lag bursts are few in number, and approximately 100 times wider (10s of seconds), have systematically lower peaks in vF(v), harder low-energy spectra and softer high-energy spectra. We find that these five pulse descriptors are essentially uncorrelated for our long-lag sample, suggesting that at least approximately 5 parameters are needed to model burst temporal and spectral behavior. However, pulse width is strongly correlated with spectral lag; hence these two parameters may be viewed as mutual surrogates. We infer that accurate formulations for estimating GRB luminosity and total energy will depend on several gamma-ray attributes, at least for long-lag bursts. The prevalence of long-lag bursts near the BATSE trigger threshold, their predominantly low vF(v) spectral peaks, and relatively steep upper power-law spectral indices indicate that Swift will detect many such bursts.

Automatic Text Structuring and Summarization.

ERIC Educational Resources Information Center

Salton, Gerard; And Others

1997-01-01

Discussion of the use of information retrieval techniques for automatic generation of semantic hypertext links focuses on automatic text summarization. Topics include World Wide Web links, text segmentation, and evaluation of text summarization by comparing automatically generated abstracts with manually prepared abstracts. (Author/LRW)

Simulations of Multi-Gamma Coincidences From Neutron-Induced Fission in Special Nuclear Materials

NASA Astrophysics Data System (ADS)

Kane, Steven; Gozani, Tsahi; King, Michael J.; Kwong, John; Brown, Craig; Gary, Charles; Firestone, Murray I.; Nikkel, James A.; McKinsey, Daniel N.

2013-04-01

A study is presented on the detection of illicit special nuclear materials (SNM) in cargo containers using a conceptual neutron-based inspection system with xenon-doped liquefied argon (LAr(Xe)) scintillation detectors for coincidence gamma-ray detection. For robustness, the system is envisioned to exploit all fission signatures, namely both prompt and delayed neutron and gamma emissions from fission reactions induced in SNM. However, this paper focuses exclusively on the analysis of the prompt gamma ray emissions. The inspection system probes a container using neutrons produced either by (d, D) or (d, T) in pulsed form or from an associated particle neutron generator to exploit the associated particle imaging (API) technique, thereby achieving background reduction and imaging. Simulated signal and background estimates were obtained in MCNPX (2.7) for a 2 kg sphere of enriched uranium positioned at the center of a 1m × 1m × 1m container, which is filled uniformly with wood or iron cargos at 0.1 g/cc or 0.4 g/cc. Detection time estimates are reported assuming probabilities of detection of 95% and false alarm of 0.5%.

PZT Thin-Film Micro Probe Device with Dual Top Electrodes

NASA Astrophysics Data System (ADS)

Luo, Chuan

Lead zirconate titanate (PZT) thin-film actuators have been studied intensively for years because of their potential applications in many fields. In this dissertation, a PZT thin-film micro probe device is designed, fabricated, studied, and proven to be acceptable as an intracochlear acoustic actuator. The micro probe device takes the form of a cantilever with a PZT thin-film diaphragm at the tip of the probe. The tip portion of the probe will be implanted in cochlea later in animal tests to prove its feasibility in hearing rehabilitation. The contribution of the dissertation is three-fold. First, a dual top electrodes design, consisting of a center electrode and an outer electrode, is developed to improve actuation displacement of the PZT thin-film diaphragm. The improvement by the dual top electrodes design is studied via a finite element model. When the dimensions of the dual electrodes are optimized, the displacement of the PZT thin-film diaphragm increases about 30%. A PZT thin-film diaphragm with dual top electrodes is fabricated to prove the concept, and experimental results confirm the predictions from the finite element analyses. Moreover, the dual electrode design can accommodate presence of significant residual stresses in the PZT thin-film diaphragm by changing the phase difference between the two electrodes. Second, a PZT thin-film micro probe device is fabricated and tested. The fabrication process consists of PZT thin-film deposition and deep reactive ion etching (DRIE). The uniqueness of the fabrication process is an automatic dicing mechanism that allows a large number of probes to be released easily from the wafer. Moreover, the fabrication is very efficient, because the DRIE process will form the PZT thin-film diaphragm and the special dicing mechanism simultaneously. After the probes are fabricated, they are tested with various possible implantation depths (i.e., boundary conditions). Experimental results show that future implantation depths

Characterization of Akiyama probe applied to dual-probes atomic force microscope

NASA Astrophysics Data System (ADS)

Wang, Hequn; Gao, Sitian; Li, Wei; Shi, Yushu; Li, Qi; Li, Shi; Zhu, Zhendong

2016-10-01

The measurement of nano-scale line-width has always been important and difficult in the field of nanometer measurements, while the rapid development of integrated circuit greatly raises the demand again. As one kind of scanning probe microscope (SPM), atomic force microscope (AFM) can realize quasi three-dimensional measurement, which is widely used in nanometer scale line-width measurement. Our team researched a dual-probes atomic force microscope, which can eliminate the prevalent effect of probe width on measurement results. In dual-probes AFM system, a novel head are newly designed. A kind of self-sensing and self-exciting probes which is Nanosensors cooperation's patented probe—Akiyama probe, is used in this novel head. The Akiyama probe applied to dual-probe atomic force microscope is one of the most important issues. The characterization of Akiyama probe would affect performance and accuracy of the whole system. The fundamental features of the Akiyama probe are electrically and optically characterized in "approach-withdraw" experiments. Further investigations include the frequency response of an Akiyama probe to small mechanical vibrations externally applied to the tip and the effective loading force yielding between the tip and the sample during the periodic contact. We hope that the characterization of the Akiyama probe described in this paper will guide application for dual-probe atomic force microscope.

Comparison of automatic control systems

NASA Technical Reports Server (NTRS)

Oppelt, W

1941-01-01

This report deals with a reciprocal comparison of an automatic pressure control, an automatic rpm control, an automatic temperature control, and an automatic directional control. It shows the difference between the "faultproof" regulator and the actual regulator which is subject to faults, and develops this difference as far as possible in a parallel manner with regard to the control systems under consideration. Such as analysis affords, particularly in its extension to the faults of the actual regulator, a deep insight into the mechanism of the regulator process.

A future wide field-of-view TeV gamma-ray observatory in the Southern Hemisphere

NASA Astrophysics Data System (ADS)

Mostafa, Miguel; HAWC Collaboration

2017-01-01

High-energy gamma-ray observations are an essential probe of cosmic-ray acceleration. Detection of the highest energies and the shortest timescales of variability are key motivations when designing the next generation of gamma-ray experiments. The Milagro experiment was the first-generation of gamma-ray detectors based on the water-Cherenkov technique, and demonstrated that it is possible to continuously monitor a large fraction of the TeV sky. The second-generation water-Cherenkov experiment, the High Altitude Water Cherenkov observatory, consists of an array of 300 water-Cherenkov detectors covering an area of 22,000 m2 at 4,100 m a.s.l. The larger effective area, the higher altitude, and the optical isolation of the detectors led to a 15-fold increase in sensitivity relative to Milagro. Instruments with a wide field of view and large duty cycle are capable of surveying the TeV sky, mapping the diffuse emission, detecting emission from extended regions, and observing transient events such as gamma ray bursts. They also have the potential for discovering electromagnetic counterparts to gravitational waves and astrophysical neutrinos. I will present the preliminary design of a third-generation water-Cherenkov observatory located at very high altitude in South America.

TeV gamma rays from 3C 279 - A possible probe of origin and intergalactic infrared radiation fields

NASA Technical Reports Server (NTRS)

Stecker, F. W.; De Jager, O. C.; Salamon, M. H.

1992-01-01

The gamma-ray spectrum of 3C 279 during 1991 June exhibited a near-perfect power law between 50 MeV and over 5 GeV with a differential spectral index of -(2.02 +/- 0.07). If extrapolated, the gamma-ray spectrum of 3C 279 should be easily detectable with first-generation air Cerenkov detectors operating above about 0.3 TeV provided there is no intergalactic absorption. However, by using model-dependent lower and upper limits for the extragalactic infrared background radiation field, a sharp cutoff of the 3C 279 spectrum is predicted at between about 0.1 and about 1 TeV. The sensitivity of present air Cerenkov detectors is good enough to measure such a cutoff, which would provide the first opportunity to obtain a measurement of the extragalactic background infrared radiation field.

High Resolution PET Imaging Probe for the Detection, Molecular Characterization and Treatment Monitoring of Prostate Cancer

DTIC Science & Technology

2012-07-01

number of high resolution PET experiments including the dual-ring small field- of-view configuration shown at left in Figure 5 . The benchtop system...detectors having 26 x 40 arrays of 1mm x 1mm x 1mm detector elements is shown at right in Figure 5 . Detectors used for probe experiments shown in...Figure 13). In the series of experiments geared towards PET application, but with the results applicable to the present single gamma case, we have

Gamma-Ray and Parsec-Scale Jet Properties of a Complete Sample of Blazars from the MOJAVE Program

NASA Technical Reports Server (NTRS)

Lister, M.L.; Aller, M.; Aller, H.; Hovatta, T.; Kellermann, K. I.; Kovalev, Y. Y.; Meyer, E. T.; Pushkarev, A. B.; Ros, E.; Ackermann, M.;

[Exploration of relationship between the expression level of DNA polymerase beta and 60Co gamma-ray radiosensitivity].

PubMed

Cui, Jie; Xu, Xin; Yang, Mo; Chen, Chen; Zhao, Wei; Wu, Mei; Zhang, Zun-zhen

2011-11-01

To explore the relationship between the expression level of DNA polymerase beta (pol beta) and 60Co gamma-ray radiosensitivity and provide a basis on improving the efficiency of radiotherapy theoretically. pol beta wild-type cells (pol beta +/+), pol beta null cells (pol beta -/-) and pol beta overexpressed cells (polp beta oe) were applied as a model system. The radiosensitivity of 60Co gamma-ray on the cell was detected by MTT assay and clone formation assay. The DCFH-DA fluorescent probe was used to examine the cellular ROS after 60Co gamma-rays radiation. MTT assay showed that after radiation by 60Co gamma-rays followed with 72 h incubation, the cell viabilities in the three kinds of cells decreased significantly with a dose-response relationship (r-/+ = -0.976, r-/- = -0.977, r(oe) = -0.982, P<0.05). In addition, the viability of pol beta -/- cell was lower than those of other two kinds of cells at the same dose (P<0.05). Likewise, the colony number and colony formation rate in all tested cells also decreased after exposure to 60Co gamma-rays. The ROS level in the three kinds of cells was enhanced after treatment with 60Co gamma-ray, and the ROS level in pol beta -/- cells was much higher than that in the other two kinds of cells (P<0.05). Cell death caused by 60Co gamma-ray may associated with the DNA oxidative damage mediated by ROS; Overexpression of pol beta could protect against oxidative DNA damage, thus the cell apoptosis/death, thereby leading to reducing the radiosensitivity of 60Co gamma-rays, while null of DNA pol beta could increase radiosensitivity of 60Co gamma-rays by compromising the DNA repair.

WE-G-BRF-09: Force- and Image-Adaptive Strategies for Robotised Placement of 4D Ultrasound Probes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kuhlemann, I; Graduate School for Computing in Life Science, University of Luebeck, Luebeck; Bruder, R

2014-06-15

Purpose: To allow continuous acquisition of high quality 4D ultrasound images for non-invasive live tracking of tumours for IGRT, image- and force-adaptive strategies for robotised placement of 4D ultrasound probes are developed and evaluated. Methods: The developed robotised ultrasound system is based on a 6-axes industrial robot (adept Viper s850) carrying a 4D ultrasound transducer with a mounted force-torque sensor. The force-adaptive placement strategies include probe position control using artificial potential fields and contact pressure regulation by a PD controller strategy. The basis for live target tracking is a continuous minimum contact pressure to ensure good image quality and highmore » patient comfort. This contact pressure can be significantly disturbed by respiratory movements and has to be compensated. All measurements were performed on human subjects under realistic conditions. When performing cardiac ultrasound, rib- and lung shadows are a common source of interference and can disrupt the tracking. To ensure continuous tracking, these artefacts had to be detected to automatically realign the probe. The detection is realised by multiple algorithms based on entropy calculations as well as a determination of the image quality. Results: Through active contact pressure regulation it was possible to reduce the variance of the contact pressure by 89.79% despite respiratory motion of the chest. The results regarding the image processing clearly demonstrate the feasibility to detect image artefacts like rib shadows in real-time. Conclusion: In all cases, it was possible to stabilise the image quality by active contact pressure control and automatically detected image artefacts. This fact enables the possibility to compensate for such interferences by realigning the probe and thus continuously optimising the ultrasound images. This is a huge step towards fully automated transducer positioning and opens the possibility for stable target tracking in

Microstructure and Mechanical Properties in Gamma(face-centered cubic) + Gamma Prime(L12) Precipitation-Strengthened Cobalt-based Superalloys

NASA Astrophysics Data System (ADS)

Bocchini, Peter J.

High-temperature structural alloys for aerospace and energy applications have long been dominated by Ni-based superalloys, whose high-temperature strength and creep resistance can be attributed to a two-phase microstructure consisting of a large volume fraction of ordered gamma'(L12)-precipitates embedded in a disordered gamma(f.c.c.)-matrix. These alloys exhibit excellent mechanical behavior and thermal stability, but after decades of incremental improvement, are nearing the theoretical limit of their operating temperatures. In 2006, an analogous gamma(f.c.c.) + gamma'(L12) microstructure was identified in the Co-Al-W ternary system with liquidus and solidus temperatures 50-150 °C higher than conventional Ni-based superalloys. The work herein focuses on assessing the effects of alloying additions on microstructure and mechanical behavior in an effort to lay the foundations for understanding this emerging alloy system. A variety of Co-based superalloys are investigated in order to study fundamental materials properties and to address key engineering challenges. Coarsening rate constants and temporal exponents are measured for gamma'(L1 2)-precipitates in a ternary Co-Al-W alloy aged at 650 °C and 750 °C. A series of Co-Al-W-B-Zr alloys are cast to study the influence of segregation of B and Zr to grain boundaries (GBs) on mechanical properties. Co-Ni-Al-W-Ti alloys with various amounts of Al, W, and Ti are cast in order to fabricate Co-based superalloys with decreased density and increased gamma'(L1 2)-solvus temperature. 2-D dislocation dynamics modeling is employed to predict how gamma'(L12)-precipitate size and volume fraction affect the mechanical properties of Ni- and Co-based superalloys. Compositional information such as phase concentrations, partitioning behavior, and GB segregation are measured with local electrode atom probe (LEAP) tomography in alloys with fine microstructures and with scanning electron microscope (SEM) electron dispersive x

Applying the new gamma ray imager diagnostic to measurements of runaway electron Bremsstrahlung radiation in the DIII-D Tokamak (invited)

NASA Astrophysics Data System (ADS)

Cooper, C. M.; Pace, D. C.; Paz-Soldan, C.; Commaux, N.; Eidietis, N. W.; Hollmann, E. M.; Shiraki, D.

2016-11-01

A new gamma ray imager (GRI) is developed to probe the electron distribution function with 2D spatial resolution during runaway electron (RE) experiments at the DIII-D tokamak. The diagnostic is sensitive to 0.5-100 MeV gamma rays, allowing characterization of the RE distribution function evolution during RE growth and dissipation. The GRI consists of a lead "pinhole camera" mounted on the DIII-D midplane with 123 honeycombed tangential chords 20 cm wide that span the vessel interior. Up to 30 bismuth germanate (BGO) scintillation detectors capture RE bremsstrahlung radiation for Pulse Height Analysis (PHA) capable of discriminating up to 20 000 pulses per second. Digital signal processing routines combining shaping filters are performed during PHA to reject noise and record gamma ray energy. The GRI setup and PHA algorithms will be described and initial data from experiments will be presented. A synthetic diagnostic is developed to generate the gamma ray spectrum of a GRI channel given the plasma information and a prescribed distribution function. Magnetic reconstructions of the plasma are used to calculate the angle between every GRI sightline and orient and discriminate gamma rays emitted by a field-aligned RE distribution function.

Applying the new gamma ray imager diagnostic to measurements of runaway electron Bremsstrahlung radiation in the DIII-D Tokamak (invited).

PubMed

Cooper, C M; Pace, D C; Paz-Soldan, C; Commaux, N; Eidietis, N W; Hollmann, E M; Shiraki, D

2016-11-01

A new gamma ray imager (GRI) is developed to probe the electron distribution function with 2D spatial resolution during runaway electron (RE) experiments at the DIII-D tokamak. The diagnostic is sensitive to 0.5-100 MeV gamma rays, allowing characterization of the RE distribution function evolution during RE growth and dissipation. The GRI consists of a lead "pinhole camera" mounted on the DIII-D midplane with 123 honeycombed tangential chords 20 cm wide that span the vessel interior. Up to 30 bismuth germanate (BGO) scintillation detectors capture RE bremsstrahlung radiation for Pulse Height Analysis (PHA) capable of discriminating up to 20 000 pulses per second. Digital signal processing routines combining shaping filters are performed during PHA to reject noise and record gamma ray energy. The GRI setup and PHA algorithms will be described and initial data from experiments will be presented. A synthetic diagnostic is developed to generate the gamma ray spectrum of a GRI channel given the plasma information and a prescribed distribution function. Magnetic reconstructions of the plasma are used to calculate the angle between every GRI sightline and orient and discriminate gamma rays emitted by a field-aligned RE distribution function.

Four-probe measurements with a three-probe scanning tunneling microscope

DOE Office of Scientific and Technical Information (OSTI.GOV)

Salomons, Mark; Martins, Bruno V. C.; Zikovsky, Janik

2014-04-15

We present an ultrahigh vacuum (UHV) three-probe scanning tunneling microscope in which each probe is capable of atomic resolution. A UHV JEOL scanning electron microscope aids in the placement of the probes on the sample. The machine also has a field ion microscope to clean, atomically image, and shape the probe tips. The machine uses bare conductive samples and tips with a homebuilt set of pliers for heating and loading. Automated feedback controlled tip-surface contacts allow for electrical stability and reproducibility while also greatly reducing tip and surface damage due to contact formation. The ability to register inter-tip position bymore » imaging of a single surface feature by multiple tips is demonstrated. Four-probe material characterization is achieved by deploying two tips as fixed current probes and the third tip as a movable voltage probe.« less

Four-probe measurements with a three-probe scanning tunneling microscope.

PubMed

Salomons, Mark; Martins, Bruno V C; Zikovsky, Janik; Wolkow, Robert A

2014-04-01

We present an ultrahigh vacuum (UHV) three-probe scanning tunneling microscope in which each probe is capable of atomic resolution. A UHV JEOL scanning electron microscope aids in the placement of the probes on the sample. The machine also has a field ion microscope to clean, atomically image, and shape the probe tips. The machine uses bare conductive samples and tips with a homebuilt set of pliers for heating and loading. Automated feedback controlled tip-surface contacts allow for electrical stability and reproducibility while also greatly reducing tip and surface damage due to contact formation. The ability to register inter-tip position by imaging of a single surface feature by multiple tips is demonstrated. Four-probe material characterization is achieved by deploying two tips as fixed current probes and the third tip as a movable voltage probe.

The effect of gamma-enhancing binaural beats on the control of feature bindings.

PubMed

Colzato, Lorenza S; Steenbergen, Laura; Sellaro, Roberta

2017-07-01

Binaural beats represent the auditory experience of an oscillating sound that occurs when two sounds with neighboring frequencies are presented to one's left and right ear separately. Binaural beats have been shown to impact information processing via their putative role in increasing neural synchronization. Recent studies of feature-repetition effects demonstrated interactions between perceptual features and action-related features: repeating only some, but not all features of a perception-action episode hinders performance. These partial-repetition (or binding) costs point to the existence of temporary episodic bindings (event files) that are automatically retrieved by repeating at least one of their features. Given that neural synchronization in the gamma band has been associated with visual feature bindings, we investigated whether the impact of binaural beats extends to the top-down control of feature bindings. Healthy adults listened to gamma-frequency (40 Hz) binaural beats or to a constant tone of 340 Hz (control condition) for ten minutes before and during a feature-repetition task. While the size of visuomotor binding costs (indicating the binding of visual and action features) was unaffected by the binaural beats, the size of visual feature binding costs (which refer to the binding between the two visual features) was considerably smaller during gamma-frequency binaural beats exposure than during the control condition. Our results suggest that binaural beats enhance selectivity in updating episodic memory traces and further strengthen the hypothesis that neural activity in the gamma band is critically associated with the control of feature binding.

Automatic Collision Avoidance Technology (ACAT)

NASA Technical Reports Server (NTRS)

Swihart, Donald E.; Skoog, Mark A.

2007-01-01

This document represents two views of the Automatic Collision Avoidance Technology (ACAT). One viewgraph presentation reviews the development and system design of Automatic Collision Avoidance Technology (ACAT). Two types of ACAT exist: Automatic Ground Collision Avoidance (AGCAS) and Automatic Air Collision Avoidance (AACAS). The AGCAS Uses Digital Terrain Elevation Data (DTED) for mapping functions, and uses Navigation data to place aircraft on map. It then scans DTED in front of and around aircraft and uses future aircraft trajectory (5g) to provide automatic flyup maneuver when required. The AACAS uses data link to determine position and closing rate. It contains several canned maneuvers to avoid collision. Automatic maneuvers can occur at last instant and both aircraft maneuver when using data link. The system can use sensor in place of data link. The second viewgraph presentation reviews the development of a flight test and an evaluation of the test. A review of the operation and comparison of the AGCAS and a pilot's performance are given. The same review is given for the AACAS is given.

Properties of the Intergalactic Magnetic Field Constrained by Gamma-Ray Observations of Gamma-Ray Bursts

DOE Office of Scientific and Technical Information (OSTI.GOV)

Veres, P.; Dermer, C. D.; Dhuga, K. S.

The magnetic field in intergalactic space gives important information about magnetogenesis in the early universe. The properties of this field can be probed by searching for radiation of secondary e {sup +} e {sup −} pairs created by TeV photons that produce GeV range radiation by Compton-scattering cosmic microwave background photons. The arrival times of the GeV “echo” photons depend strongly on the magnetic field strength and coherence length. A Monte Carlo code that accurately treats pair creation is developed to simulate the spectrum and time-dependence of the echo radiation. The extrapolation of the spectrum of powerful gamma-ray bursts (GRBs)more » like GRB 130427A to TeV energies is used to demonstrate how the intergalactic magnetic field can be constrained if it falls in the 10{sup −21}–10{sup −17} G range for a 1 Mpc coherence length.« less

Method of incident low-energy gamma-ray direction reconstruction in the GAMMA-400 gamma-ray space telescope

NASA Astrophysics Data System (ADS)

Kheymits, M. D.; Leonov, A. A.; Zverev, V. G.; Galper, A. M.; Arkhangelskaya, I. V.; Arkhangelskiy, A. I.; Suchkov, S. I.; Topchiev, N. P.; Yurkin, Yu T.; Bakaldin, A. V.; Dalkarov, O. D.

2016-02-01

The GAMMA-400 gamma-ray space-based telescope has as its main goals to measure cosmic γ-ray fluxes and the electron-positron cosmic-ray component produced, theoretically, in dark-matter-particles decay or annihilation processes, to search for discrete γ-ray sources and study them in detail, to examine the energy spectra of diffuse γ-rays — both galactic and extragalactic — and to study gamma-ray bursts (GRBs) and γ-rays from the active Sun. Scientific goals of GAMMA-400 telescope require fine angular resolution. The telescope is of a pair-production type. In the converter-tracker, the incident gamma-ray photon converts into electron-positron pair in the tungsten layer and then the tracks are detected by silicon- strip position-sensitive detectors. Multiple scattering processes become a significant obstacle in the incident-gamma direction reconstruction for energies below several gigaelectronvolts. The method of utilising this process to improve the resolution is proposed in the presented work.

Multiparameter spatio-thermochemical probing of flame–wall interactions advanced with coherent Raman imaging

DOE PAGES

Bohlin, Gustav Alexis; Jainski, Christopher; Patterson, Brian D.; ...

2016-08-10

Ultrabroadband coherent anti-Stokes Ra man spectroscopy (CARS) has been developed for one -dimensional imaging of temperature and major species distributions simultaneously in the near-wall region of a methane/air flame supported on a side-wall-quenching (SWQ) burner. Automatic temporal and spatial overlap of the ~7 femtosecond pump and Stokes pulses is achieved utilizing a two-beam CARS phase-matching scheme, and the crossed ~75 picosecond probe beam provide s excellent spatial sectioning of the probed location. Concurrent detection of N 2, O 2, H 2, CO, CO 2, and CH 4 is demonstrated while high-fidelity flame thermometry is assessed from the N 2 puremore » rotational S-branch in a one-dimensional -CARS imaging configuration. A methane/air premixed flame at lean, stoichiometric, and rich conditions ( Φ = 0.83, 1.0 , and 1.2) and Reynolds number = 5,000 is probed as it quenches against a cooled steel side- wall parallel to the flow providing a persistent flame-wall interaction. Here, an imaging resolution of better than 40 μm is achieved across the field -of-view, thus allowing thermochemical states (temperature and major species) of the thermal boundary layer to be resolved to within ~30 μm of the interface.« less

Multiparameter spatio-thermochemical probing of flame–wall interactions advanced with coherent Raman imaging

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bohlin, Gustav Alexis; Jainski, Christopher; Patterson, Brian D.

Ultrabroadband coherent anti-Stokes Ra man spectroscopy (CARS) has been developed for one -dimensional imaging of temperature and major species distributions simultaneously in the near-wall region of a methane/air flame supported on a side-wall-quenching (SWQ) burner. Automatic temporal and spatial overlap of the ~7 femtosecond pump and Stokes pulses is achieved utilizing a two-beam CARS phase-matching scheme, and the crossed ~75 picosecond probe beam provide s excellent spatial sectioning of the probed location. Concurrent detection of N 2, O 2, H 2, CO, CO 2, and CH 4 is demonstrated while high-fidelity flame thermometry is assessed from the N 2 puremore » rotational S-branch in a one-dimensional -CARS imaging configuration. A methane/air premixed flame at lean, stoichiometric, and rich conditions ( Φ = 0.83, 1.0 , and 1.2) and Reynolds number = 5,000 is probed as it quenches against a cooled steel side- wall parallel to the flow providing a persistent flame-wall interaction. Here, an imaging resolution of better than 40 μm is achieved across the field -of-view, thus allowing thermochemical states (temperature and major species) of the thermal boundary layer to be resolved to within ~30 μm of the interface.« less

Fluorimetric determination of proteins using 4-chloro-(2'-hydroxylophenylazo)rhodanine-Ti(IV) complex as a spectral probe.

PubMed

Sun, Shuting; Ma, Hongmin; Chen, Xin; Zhang, Nuo; Wu, Dan; Du, Bin; Wei, Qin

2008-01-01

A novel method for the determination of proteins was developed, based on the enhancement of fluorescence with 4-chloro-(2'-hydroxylophenylazo)rhodanine-Ti(IV) [ClHARP-Ti(IV)] complex as a fluorescence probe. The excitation and emission wavelengths of the system were 335 nm and 376 nm, respectively. The presence of bis(2-ethylhexyl)sulphosuccinate sodium salt (AOT) microemulsion greatly increased the sensitivity of the system. Under optimal conditions, four kinds of proteins, including bovine serum albumin (BSA), human serum albumin (HSA), egg albumin (Ova), and gamma-globin (gamma-G) were studied. The detection limits were 0.182 microg/mL for BSA, 0.0788 microg/mL for HSA, 0.216 microg/mL for Ova and 0.484 microg/mL for gamma-G. The linear ranges of the calibration were 0-12.0, 0-10.0, 0-18.0 and 0-18.0 microg/mL, respectively. The method possessed high sensitivity, good selectivity and was applied to the analysis of protein in milk powder and cornmeal with satisfactory results.

An automatic dose verification system for adaptive radiotherapy for helical tomotherapy

NASA Astrophysics Data System (ADS)

Mo, Xiaohu; Chen, Mingli; Parnell, Donald; Olivera, Gustavo; Galmarini, Daniel; Lu, Weiguo

2014-03-01

Purpose: During a typical 5-7 week treatment of external beam radiotherapy, there are potential differences between planned patient's anatomy and positioning, such as patient weight loss, or treatment setup. The discrepancies between planned and delivered doses resulting from these differences could be significant, especially in IMRT where dose distributions tightly conforms to target volumes while avoiding organs-at-risk. We developed an automatic system to monitor delivered dose using daily imaging. Methods: For each treatment, a merged image is generated by registering the daily pre-treatment setup image and planning CT using treatment position information extracted from the Tomotherapy archive. The treatment dose is then computed on this merged image using our in-house convolution-superposition based dose calculator implemented on GPU. The deformation field between merged and planning CT is computed using the Morphon algorithm. The planning structures and treatment doses are subsequently warped for analysis and dose accumulation. All results are saved in DICOM format with private tags and organized in a database. Due to the overwhelming amount of information generated, a customizable tolerance system is used to flag potential treatment errors or significant anatomical changes. A web-based system and a DICOM-RT viewer were developed for reporting and reviewing the results. Results: More than 30 patients were analysed retrospectively. Our in-house dose calculator passed 97% gamma test evaluated with 2% dose difference and 2mm distance-to-agreement compared with Tomotherapy calculated dose, which is considered sufficient for adaptive radiotherapy purposes. Evaluation of the deformable registration through visual inspection showed acceptable and consistent results, except for cases with large or unrealistic deformation. Our automatic flagging system was able to catch significant patient setup errors or anatomical changes. Conclusions: We developed an automatic dose

Design and Performance of the GAMMA-400 Gamma-Ray Telescope for Dark Matter Searches

NASA Technical Reports Server (NTRS)

Galper, A.M.; Adriani, O.; Aptekar, R. L.; Arkhangelskaja, I. V.; Arkhangelskiy, A.I.; Boezio, M.; Bonvicini, V.; Boyarchuk, K. A.; Fradkin, M. I.; Gusakov, Yu. V.;

Automatic Coal-Mining System

NASA Technical Reports Server (NTRS)

Collins, E. R., Jr.

1985-01-01

Coal cutting and removal done with minimal hazard to people. Automatic coal mine cutting, transport and roof-support movement all done by automatic machinery. Exposure of people to hazardous conditions reduced to inspection tours, maintenance, repair, and possibly entry mining.

Ring-averaged ion velocity distribution function probe for laboratory magnetized plasma experiment

NASA Astrophysics Data System (ADS)

Kawamori, Eiichirou; Chen, Jinting; Lin, Chiahsuan; Lee, Zongmau

2017-10-01

Ring-averaged velocity distribution function of ions at a fixed guiding center position is a fundamental quantity in the gyrokinetic plasma physics. We have developed a diagnostic tool for the ring averaged velocity distribution function of ions for laboratory plasma experiments, which is named as the ring-averaged ion distribution function probe (RIDFP). The RIDFP is a set of ion collectors for different velocities. It is designed to be immersed in magnetized plasmas and achieves momentum selection of incoming ions by the selection of the ion Larmor radii. To nullify the influence of the sheath potential surrounding the RIDFP on the orbits of the incoming ions, the electrostatic potential of the RIDFP body is automatically adjusted to coincide with the space potential of the target plasma with the use of an emissive probe and a voltage follower. The developed RIDFP successfully measured the equilibrium ring-averaged velocity distribution function of a laboratory magnetized plasma, which was in accordance with the Maxwellian distribution having an ion temperature of 0.2 eV.

Ring-averaged ion velocity distribution function probe for laboratory magnetized plasma experiment.

PubMed

Kawamori, Eiichirou; Chen, Jinting; Lin, Chiahsuan; Lee, Zongmau

2017-10-01

Ring-averaged velocity distribution function of ions at a fixed guiding center position is a fundamental quantity in the gyrokinetic plasma physics. We have developed a diagnostic tool for the ring averaged velocity distribution function of ions for laboratory plasma experiments, which is named as the ring-averaged ion distribution function probe (RIDFP). The RIDFP is a set of ion collectors for different velocities. It is designed to be immersed in magnetized plasmas and achieves momentum selection of incoming ions by the selection of the ion Larmor radii. To nullify the influence of the sheath potential surrounding the RIDFP on the orbits of the incoming ions, the electrostatic potential of the RIDFP body is automatically adjusted to coincide with the space potential of the target plasma with the use of an emissive probe and a voltage follower. The developed RIDFP successfully measured the equilibrium ring-averaged velocity distribution function of a laboratory magnetized plasma, which was in accordance with the Maxwellian distribution having an ion temperature of 0.2 eV.

Traversing probe system

DOEpatents

Mashburn, Douglas N.; Stevens, Richard H.; Woodall, Harold C.

1977-01-01

This invention comprises a rotatable annular probe-positioner which carries at least one radially disposed sensing probe, such as a Pitot tube having a right-angled tip. The positioner can be coaxially and rotatably mounted within a compressor casing or the like and then actuated to orient the sensing probe as required to make measurements at selected stations in the annulus between the positioner and compressor casing. The positioner can be actuated to (a) selectively move the probe along its own axis, (b) adjust the yaw angle of the right-angled probe tip, and (c) revolve the probe about the axis common to the positioner and casing. A cam plate engages a cam-follower portion of the probe and normally rotates with the positioner. The positioner includes a first-motor-driven ring gear which effects slidable movement of the probe by rotating the positioner at a time when an external pneumatic cylinder is actuated to engage the cam plate and hold it stationary. When the pneumatic cylinder is not actuated, this ring gear can be driven to revolve the positioner and thus the probe to a desired circumferential location about the above-mentioned common axis. A second motor-driven ring gear included in the positioner can be driven to rotate the probe about its axis, thus adjusting the yaw angle of the probe tip. The positioner can be used in highly corrosive atmosphere, such as gaseous uranium hexafluoride.

Cosmic Gamma-Rays

Science.gov Websites

[Argonne Logo] [DOE Logo] Cosmic Gamma-Rays Home Publications Talks People Students Argonne > ; HEP > Cosmic Gamma-Rays Projects VERITAS Past Projects TrICE What's New CTA Cosmic Gamma-Rays The

Gamma-Ray Bursts: Characteristics and Prospects

NASA Astrophysics Data System (ADS)

Azzam, W. J.; Zitouni, H.; Guessoum, N.

2017-06-01

Gamma-ray bursts (GRBs) are the most powerful explosions in the universe. They have remained the object of intense research ever since their discovery was declassified in the early 1970s. Several space-borne missions have been dedicated to their study, including the Compton Gamma-Ray Burst Observatory (CGRO) in the 1990s and the current Swift and Fermi satellites. However, despite several decades of focused research, the precise mechanisms behind these enigmatic explosions have not been fully established. In the first part of this paper, we review what is currently known about GRBs. This includes: GRB light-curves and spectra; the different progenitor models, i.e., the "collapsar" and "merger" models; and the afterglow characteristics, including external shocks and the surrounding medium. In the second part of the paper, we present our work, which focuses on utilizing GRBs as cosmological probes. GRBs are ideal cosmological tools, because they have been observed to great distances (redshifts up to z = 9.4) and their radiation is unencumbered by any intervening dust. Although GRBs are not standard candles, the discovery of several energy and luminosity correlations, like the Amati relation which correlates the intrinsic spectral peak energy, Ep,i to the equivalent isotropic energy, Eiso , has ushered in a new era in which GRBs are used to investigate cosmological issues like the star formation rate and the value of the matter-density parameter, ΩM.

Design and Performance of the GAMMA-400 Gamma-Ray Telescope for Dark Matter Searches

NASA Technical Reports Server (NTRS)

Galper, A. M.; Adriani, O.; Aptekar, R. L.; Arkhangelskaja, I. V.; Arkhangelskiy, A. I.; Boezio, M.; Bonvicini, V.; Boyarchuk, K. A.; Fradkin, M. I.; Gusakov, Yu V.;

Impact of intense x-ray pulses on a NaI(Tl)-based gamma camera

NASA Astrophysics Data System (ADS)

Koppert, W. J. C.; van der Velden, S.; Steenbergen, J. H. L.; de Jong, H. W. A. M.

2018-03-01

In SPECT/CT systems x-ray and γ-ray imaging is performed sequentially. Simultaneous acquisition may have advantages, for instance in interventional settings. However, this may expose a gamma camera to relatively high x-ray doses and deteriorate its functioning. We studied the NaI(Tl) response to x-ray pulses with a photodiode, PMT and gamma camera, respectively. First, we exposed a NaI(Tl)-photodiode assembly to x-ray pulses to investigate potential crystal afterglow. Next, we exposed a NaI(Tl)-PMT assembly to 10 ms LED pulses (mimicking x-ray pulses) and measured the response to flashing LED probe-pulses (mimicking γ-pulses). We then exposed the assembly to x-ray pulses, with detector entrance doses of up to 9 nGy/pulse, and analysed the response for γ-pulse variations. Finally, we studied the response of a Siemens Diacam gamma camera to γ-rays while exposed to x-ray pulses. X-ray exposure of the crystal, read out with a photodiode, revealed 15% afterglow fraction after 3 ms. The NaI(Tl)-PMT assembly showed disturbances up to 10 ms after 10 ms LED exposure. After x-ray exposure however, responses showed elevated baselines, with 60 ms decay-time. Both for x-ray and LED exposure and after baseline subtraction, probe-pulse analysis revealed disturbed pulse height measurements shortly after exposure. X-ray exposure of the Diacam corroborated the elementary experiments. Up to 50 ms after an x-ray pulse, no events are registered, followed by apparent energy elevations up to 100 ms after exposure. Limiting the dose to 0.02 nGy/pulse prevents detrimental effects. Conventional gamma cameras exhibit substantial dead-time and mis-registration of photon energies up to 100 ms after intense x-ray pulses. This is due PMT limitations and due to afterglow in the crystal. Using PMTs with modified circuitry, we show that deteriorative afterglow effects can be reduced without noticeable effects on the PMT performance, up to x-ray pulse doses of 1 nGy.

The Oxford Probe: an open access five-hole probe for aerodynamic measurements

NASA Astrophysics Data System (ADS)

Hall, B. F.; Povey, T.

2017-03-01

The Oxford Probe is an open access five-hole probe designed for experimental aerodynamic measurements. The open access probe can be manufactured by the end user via additive manufacturing (metal or plastic). The probe geometry, drawings, calibration maps, and software are available under a creative commons license. The purpose is to widen access to aerodynamic measurement techniques in education and research environments. There are many situations in which the open access probe will allow results of comparable accuracy to a well-calibrated commercial probe. We discuss the applications and limitations of the probe, and compare the calibration maps for 16 probes manufactured in different materials and at different scales, but with the same geometrical design.

Magnification concepts: The use of video-probe microscopy to stimulate excitement and hands-on discovery in the science classroom K-12

DOE Office of Scientific and Technical Information (OSTI.GOV)

Henk, C.; Garner, J.; Wandersee, J.H.

1994-12-31

We acquired and loaned several durable, easy-to use, though expensive video-probe microscopes. This hand-held, automatically focusing instrument can be used by a five year old and provides instant, excellent, in-focus images up to 200X on a video screen visible to all students simultaneously. The teacher is thus freed from the technical and logistic considerations involved in conventional classroom microscopy. K-12 teachers preview our videotape on probe utilization. They assemble and demonstrate the unit in the presence of our personnel, then check out the probe for use in their own classrooms. Extremely enthusiastic students examine samples ranging from their own fingerprintsmore » and clothing (on TV!) to pond water, prepared microscope slides, and microscope polarizing light phenomena. Teachers report heightened interest in conventional microscope use once the {open_quotes}microscopy connection{close_quotes} has been made.« less

Automatic switching matrix

DOEpatents

Schlecht, Martin F.; Kassakian, John G.; Caloggero, Anthony J.; Rhodes, Bruce; Otten, David; Rasmussen, Neil

1982-01-01

An automatic switching matrix that includes an apertured matrix board containing a matrix of wires that can be interconnected at each aperture. Each aperture has associated therewith a conductive pin which, when fully inserted into the associated aperture, effects electrical connection between the wires within that particular aperture. Means is provided for automatically inserting the pins in a determined pattern and for removing all the pins to permit other interconnecting patterns.

In vivo reproducibility of robotic probe placement for an integrated US-CT image-guided radiation therapy system

NASA Astrophysics Data System (ADS)

Lediju Bell, Muyinatu A.; Sen, H. Tutkun; Iordachita, Iulian; Kazanzides, Peter; Wong, John

2014-03-01

Radiation therapy is used to treat cancer by delivering high-dose radiation to a pre-defined target volume. Ultrasound (US) has the potential to provide real-time, image-guidance of radiation therapy to identify when a target moves outside of the treatment volume (e.g. due to breathing), but the associated probe-induced tissue deformation causes local anatomical deviations from the treatment plan. If the US probe is placed to achieve similar tissue deformations in the CT images required for treatment planning, its presence causes streak artifacts that will interfere with treatment planning calculations. To overcome these challenges, we propose robot-assisted placement of a real ultrasound probe, followed by probe removal and replacement with a geometrically-identical, CT-compatible model probe. This work is the first to investigate in vivo deformation reproducibility with the proposed approach. A dog's prostate, liver, and pancreas were each implanted with three 2.38-mm spherical metallic markers, and the US probe was placed to visualize the implanted markers in each organ. The real and model probes were automatically removed and returned to the same position (i.e. position control), and CT images were acquired with each probe placement. The model probe was also removed and returned with the same normal force measured with the real US probe (i.e. force control). Marker positions in CT images were analyzed to determine reproducibility, and a corollary reproducibility study was performed on ex vivo tissue. In vivo results indicate that tissue deformations with the real probe were repeatable under position control for the prostate, liver, and pancreas, with median 3D reproducibility of 0.3 mm, 0.3 mm, and 1.6 mm, respectively, compared to 0.6 mm for the ex vivo tissue. For the prostate, the mean 3D tissue displacement errors between the real and model probes were 0.2 mm under position control and 0.6 mm under force control, which are both within acceptable

{gamma}-RAY AND PARSEC-SCALE JET PROPERTIES OF A COMPLETE SAMPLE OF BLAZARS FROM THE MOJAVE PROGRAM

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lister, M. L.; Hovatta, T.; Aller, M.

We investigate the Fermi Large Area Telescope {gamma}-ray and 15 GHz Very Long Baseline Array radio properties of a joint {gamma}-ray and radio-selected sample of active galactic nuclei (AGNs) obtained during the first 11 months of the Fermi mission (2008 August 4-2009 July 5). Our sample contains the brightest 173 AGNs in these bands above declination -30 Degree-Sign during this period, and thus probes the full range of {gamma}-ray loudness ({gamma}-ray to radio band luminosity ratio) in the bright blazar population. The latter quantity spans at least 4 orders of magnitude, reflecting a wide range of spectral energy distribution (SED)more » parameters in the bright blazar population. The BL Lac objects, however, display a linear correlation of increasing {gamma}-ray loudness with synchrotron SED peak frequency, suggesting a universal SED shape for objects of this class. The synchrotron self-Compton model is favored for the {gamma}-ray emission in these BL Lac objects over external seed photon models, since the latter predict a dependence of Compton dominance on Doppler factor that would destroy any observed synchrotron SED-peak-{gamma}-ray-loudness correlation. The high-synchrotron peaked (HSP) BL Lac objects are distinguished by lower than average radio core brightness temperatures, and none display large radio modulation indices or high linear core polarization levels. No equivalent trends are seen for the flat-spectrum radio quasars (FSRQs) in our sample. Given the association of such properties with relativistic beaming, we suggest that the HSP BL Lac objects have generally lower Doppler factors than the lower-synchrotron peaked BL Lac objects or FSRQs in our sample.« less

Development of a Small-Sized, Flexible, and Insertable Fiber-Optic Radiation Sensor for Gamma-Ray Spectroscopy

PubMed Central

Yoo, Wook Jae; Shin, Sang Hun; Lee, Dong Eun; Jang, Kyoung Won; Cho, Seunghyun; Lee, Bongsoo

2015-01-01

We fabricated a small-sized, flexible, and insertable fiber-optic radiation sensor (FORS) that is composed of a sensing probe, a plastic optical fiber (POF), a photomultiplier tube (PMT)-amplifier system, and a multichannel analyzer (MCA) to obtain the energy spectra of radioactive isotopes. As an inorganic scintillator for gamma-ray spectroscopy, a cerium-doped lutetium yttrium orthosilicate (LYSO:Ce) crystal was used and two solid-disc type radioactive isotopes with the same dimensions, cesium-137 (Cs-137) and cobalt-60 (Co-60), were used as gamma-ray emitters. We first determined the length of the LYSO:Ce crystal considering the absorption of charged particle energy and measured the gamma-ray energy spectra using the FORS. The experimental results demonstrated that the proposed FORS can be used to discriminate species of radioactive isotopes by measuring their inherent energy spectra, even when gamma-ray emitters are mixed. The relationship between the measured photon counts of the FORS and the radioactivity of Cs-137 was subsequently obtained. The amount of scintillating light generated from the FORS increased by increasing the radioactivity of Cs-137. Finally, the performance of the fabricated FORS according to the length and diameter of the POF was also evaluated. Based on the results of this study, it is anticipated that a novel FORS can be developed to accurately measure the gamma-ray energy spectrum in inaccessible locations such as narrow areas and holes. PMID:26343667

Optical gamma thermometer

DOEpatents

Koster, Glen Peter; Xia, Hua; Lee, Boon Kwee

2013-08-06

An optical gamma thermometer includes a metal mass having a temperature proportional to a gamma flux within a core of a nuclear reactor, and an optical fiber cable for measuring the temperature of the heated metal mass. The temperature of the heated mass may be measured by using one or more fiber grating structures and/or by using scattering techniques, such as Raman, Brillouin, and the like. The optical gamma thermometer may be used in conjunction with a conventional reactor heat balance to calibrate the local power range monitors over their useful in-service life. The optical gamma thermometer occupies much less space within the in-core instrument tube and costs much less than the conventional gamma thermometer.

Electrical resistivity probes

DOEpatents

Lee, Ki Ha; Becker, Alex; Faybishenko, Boris A.; Solbau, Ray D.

2003-10-21

A miniaturized electrical resistivity (ER) probe based on a known current-voltage (I-V) electrode structure, the Wenner array, is designed for local (point) measurement. A pair of voltage measuring electrodes are positioned between a pair of current carrying electrodes. The electrodes are typically about 1 cm long, separated by 1 cm, so the probe is only about 1 inch long. The electrodes are mounted to a rigid tube with electrical wires in the tube and a sand bag may be placed around the electrodes to protect the electrodes. The probes can be positioned in a borehole or on the surface. The electrodes make contact with the surrounding medium. In a dual mode system, individual probes of a plurality of spaced probes can be used to measure local resistance, i.e. point measurements, but the system can select different probes to make interval measurements between probes and between boreholes.

Implications of Gamma-Ray Transparency Constraints in Blazars: Minimum Distances and Gamma-Ray Collimation

NASA Technical Reports Server (NTRS)

Becker, Peter A.; Kafatos, Menas

1995-01-01

We develop a general expression for the gamma - gamma absorption coefficient, alpha(sub gamma(gamma)) for gamma-rays propagating in an arbitrary direction at an arbitrary point in space above an X-ray-emitting accretion disk. The X-ray intensity is assumed to vary as a power law in energy and radius between the outer disk radius, R(sub 0), and the inner radius, R(sub ms) which is the radius of marginal stability for a Schwarzschild black hole. We use our result for alpha(sub gamma(gamma)) to calculate the gamma - gamma optical depth, tau(sub gamma(gamma)) for gamma - rays created at height z and propagating at angle Phi relative to the disk axis, and we show that for Phi = 0 and z greater than or approx equal to R(sub 0), tau(sub gamma(gamma)) proportional to Epsilon(sup alpha)z(sup -2(alpha) - 3), where alpha is the X-ray spectral index and Epsilon is the gamma - ray energy. As an application, we use our formalism to compute the minimum distance between the central black hole and the site of production of the gamma-rays detected by EGRET during the 1991 June flare of 3C 279. In order to obtain an upper limit, we assume that all of the X-rays observed contemporaneously by Ginga were emitted by the disk. Our results suggest that the observed gamma - rays may have originated within less than or approx equal to 45 GM/sq c from a black hole of mass greater than or approx equal to 10(exp 9) solar mass, perhaps in active plasma located above the central funnel of the accretion disk. This raises the possibility of establishing a direct connection between the production of the observed gamma - rays and the accretion of material onto the black hole. We also consider the variation of the optical depth as a function of the angle of propagation Phi. Our results indicate that the "focusing" of the gamma - rays along the disk axis due to pair production is strong enough to explain the observed degree of alignment in blazar sources. If the gamma - rays are produced isotropically

Design and performance of the GAMMA-400 gamma-ray telescope for dark matter searches

NASA Astrophysics Data System (ADS)

Galper, A. M.; Adriani, O.; Aptekar, R. L.; Arkhangelskaja, I. V.; Arkhangelskiy, A. I.; Boezio, M.; Bonvicini, V.; Boyarchuk, K. A.; Fradkin, M. I.; Gusakov, Yu. V.; Kaplin, V. A.; Kachanov, V. A.; Kheymits, M. D.; Leonov, A. A.; Longo, F.; Mazets, E. P.; Maestro, P.; Marrocchesi, P.; Mereminskiy, I. A.; Mikhailov, V. V.; Moiseev, A. A.; Mocchiutti, E.; Mori, N.; Moskalenko, I. V.; Naumov, P. Yu.; Papini, P.; Picozza, P.; Rodin, V. G.; Runtso, M. F.; Sparvoli, R.; Spillantini, P.; Suchkov, S. I.; Tavani, M.; Topchiev, N. P.; Vacchi, A.; Vannuccini, E.; Yurkin, Yu. T.; Zampa, N.; Zverev, V. G.; Zirakashvili, V. N.

2013-02-01

The GAMMA-400 gamma-ray telescope is designed to measure the fluxes of gamma-rays and cosmic-ray electrons + positrons, which can be produced by annihilation or decay of the dark matter particles, as well as to survey the celestial sphere in order to study point and extended sources of gamma-rays, measure energy spectra of Galactic and extragalactic diffuse gamma-ray emission, gamma-ray bursts, and gamma-ray emission from the Sun. GAMMA-400 covers the energy range from 100 MeV to 3000 GeV. Its angular resolution is ~0.01° (Eγ > 100 GeV), the energy resolution ~1% (Eγ > 10 GeV), and the proton rejection factor ~106. GAMMA-400 will be installed on the Russian space platform Navigator. The beginning of observations is planned for 2018.

Constraints on cosmological dark matter annihilation from the Fermi-LAT isotropic diffuse gamma-ray measurement

DOE PAGES

Abdo, A. A.; Ackermann, M.; Ajello, M.; ...

2010-04-01

The first published Fermi large area telescope (Fermi-LAT) measurement of the isotropic diffuse gamma-ray emission is in good agreement with a single power law, and is not showing any signature of a dominant contribution from dark matter sources in the energy range from 20 to 100 GeV. Here, we use the absolute size and spectral shape of this measured flux to derive cross section limits on three types of generic dark matter candidates: annihilating into quarks, charged leptons and monochromatic photons. Predicted gamma-ray fluxes from annihilating dark matter are strongly affected by the underlying distribution of dark matter, and bymore » using different available results of matter structure formation we assess these uncertainties. We also quantify how the dark matter constraints depend on the assumed conventional backgrounds and on the Universe's transparency to high-energy gamma-rays. In reasonable background and dark matter structure scenarios (but not in all scenarios we consider) it is possible to exclude models proposed to explain the excess of electrons and positrons measured by the Fermi-LAT and PAMELA experiments. Derived limits also start to probe cross sections expected from thermally produced relics (e.g. in minimal supersymmetry models) annihilating predominantly into quarks. Finally, for the monochromatic gamma-ray signature, the current measurement constrains only dark matter scenarios with very strong signals.« less

An automatic system to study sperm motility and energetics.

PubMed

Shi, Linda Z; Nascimento, Jaclyn M; Chandsawangbhuwana, Charlie; Botvinick, Elliot L; Berns, Michael W

2008-08-01

An integrated robotic laser and microscope system has been developed to automatically analyze individual sperm motility and energetics. The custom-designed optical system directs near-infrared laser light into an inverted microscope to create a single-point 3-D gradient laser trap at the focal spot of the microscope objective. A two-level computer structure is described that quantifies the sperm motility (in terms of swimming speed and swimming force) and energetics (measuring mid-piece membrane potential) using real-time tracking (done by the upper-level system) and fluorescent ratio imaging (done by the lower-level system). The communication between these two systems is achieved by a gigabit network. The custom-built image processing algorithm identifies the sperm swimming trajectory in real-time using phase contrast images, and then subsequently traps the sperm by automatically moving the microscope stage to relocate the sperm to the laser trap focal plane. Once the sperm is stably trapped (determined by the algorithm), the algorithm can also gradually reduce the laser power by rotating the polarizer in the laser path to measure the trapping power at which the sperm is capable of escaping the trap. To monitor the membrane potential of the mitochondria located in a sperm's mid-piece, the sperm is treated with a ratiometrically-encoded fluorescent probe. The proposed algorithm can relocate the sperm to the center of the ratio imaging camera and the average ratio value can be measured in real-time. The three parameters, sperm escape power, sperm swimming speed and ratio values of the mid-piece membrane potential of individual sperm can be compared with respect to time. This two-level automatic system to study individual sperm motility and energetics has not only increased experimental throughput by an order of magnitude but also has allowed us to monitor sperm energetics prior to and after exposure to the laser trap. This system should have application in both the

An automatic system to study sperm motility and energetics

PubMed Central

Nascimento, Jaclyn M.; Chandsawangbhuwana, Charlie; Botvinick, Elliot L.; Berns, Michael W.

2012-01-01

An integrated robotic laser and microscope system has been developed to automatically analyze individual sperm motility and energetics. The custom-designed optical system directs near-infrared laser light into an inverted microscope to create a single-point 3-D gradient laser trap at the focal spot of the microscope objective. A two-level computer structure is described that quantifies the sperm motility (in terms of swimming speed and swimming force) and energetics (measuring mid-piece membrane potential) using real-time tracking (done by the upper-level system) and fluorescent ratio imaging (done by the lower-level system). The communication between these two systems is achieved by a gigabit network. The custom-built image processing algorithm identifies the sperm swimming trajectory in real-time using phase contrast images, and then subsequently traps the sperm by automatically moving the microscope stage to relocate the sperm to the laser trap focal plane. Once the sperm is stably trapped (determined by the algorithm), the algorithm can also gradually reduce the laser power by rotating the polarizer in the laser path to measure the trapping power at which the sperm is capable of escaping the trap. To monitor the membrane potential of the mitochondria located in a sperm’s mid-piece, the sperm is treated with a ratiometrically-encoded fluorescent probe. The proposed algorithm can relocate the sperm to the center of the ratio imaging camera and the average ratio value can be measured in real-time. The three parameters, sperm escape power, sperm swimming speed and ratio values of the mid-piece membrane potential of individual sperm can be compared with respect to time. This two-level automatic system to study individual sperm motility and energetics has not only increased experimental throughput by an order of magnitude but also has allowed us to monitor sperm energetics prior to and after exposure to the laser trap. This system should have application in both

Selection of optimal oligonucleotide probes for microarrays usingmultiple criteria, global alignment and parameter estimation.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Li, Xingyuan; He, Zhili; Zhou, Jizhong

2005-10-30

The oligonucleotide specificity for microarray hybridizationcan be predicted by its sequence identity to non-targets, continuousstretch to non-targets, and/or binding free energy to non-targets. Mostcurrently available programs only use one or two of these criteria, whichmay choose 'false' specific oligonucleotides or miss 'true' optimalprobes in a considerable proportion. We have developed a software tool,called CommOligo using new algorithms and all three criteria forselection of optimal oligonucleotide probes. A series of filters,including sequence identity, free energy, continuous stretch, GC content,self-annealing, distance to the 3'-untranslated region (3'-UTR) andmelting temperature (Tm), are used to check each possibleoligonucleotide. A sequence identity is calculated based onmore » gapped globalalignments. A traversal algorithm is used to generate alignments for freeenergy calculation. The optimal Tm interval is determined based on probecandidates that have passed all other filters. Final probes are pickedusing a combination of user-configurable piece-wise linear functions andan iterative process. The thresholds for identity, stretch and freeenergy filters are automatically determined from experimental data by anaccessory software tool, CommOligo_PE (CommOligo Parameter Estimator).The program was used to design probes for both whole-genome and highlyhomologous sequence data. CommOligo and CommOligo_PE are freely availableto academic users upon request.« less

Ultrafast scanning probe microscopy

DOEpatents

Weiss, Shimon; Chemla, Daniel S.; Ogletree, D. Frank; Botkin, David

1995-01-01

An ultrafast scanning probe microscopy method for achieving subpicosecond-temporal resolution and submicron-spatial resolution of an observation sample. In one embodiment of the present claimed invention, a single short optical pulse is generated and is split into first and second pulses. One of the pulses is delayed using variable time delay means. The first pulse is then directed at an observation sample located proximate to the probe of a scanning probe microscope. The scanning probe microscope produces probe-sample signals indicative of the response of the probe to characteristics of the sample. The second pulse is used to modulate the probe of the scanning probe microscope. The time delay between the first and second pulses is then varied. The probe-sample response signal is recorded at each of the various time delays created between the first and second pulses. The probe-sample response signal is then plotted as a function of time delay to produce a cross-correlation of the probe sample response. In so doing, the present invention provides simultaneous subpicosecond-temporal resolution and submicron-spatial resolution of the sample.

Automatic assembly of micro-optical components

NASA Astrophysics Data System (ADS)

Gengenbach, Ulrich K.

1996-12-01

Automatic assembly becomes an important issue as hybrid micro systems enter industrial fabrication. Moving from a laboratory scale production with manual assembly and bonding processes to automatic assembly requires a thorough re- evaluation of the design, the characteristics of the individual components and of the processes involved. Parts supply for automatic operation, sensitive and intelligent grippers adapted to size, surface and material properties of the microcomponents gain importance when the superior sensory and handling skills of a human are to be replaced by a machine. This holds in particular for the automatic assembly of micro-optical components. The paper outlines these issues exemplified at the automatic assembly of a micro-optical duplexer consisting of a micro-optical bench fabricated by the LIGA technique, two spherical lenses, a wavelength filter and an optical fiber. Spherical lenses, wavelength filter and optical fiber are supplied by third party vendors, which raises the question of parts supply for automatic assembly. The bonding processes for these components include press fit and adhesive bonding. The prototype assembly system with all relevant components e.g. handling system, parts supply, grippers and control is described. Results of first automatic assembly tests are presented.

Probing Gamma-ray Emission of Geminga and Vela with Non-stationary Models

NASA Astrophysics Data System (ADS)

Chai, Yating; Cheng, Kwong-Sang; Takata, Jumpei

2016-06-01

It is generally believed that the high energy emissions from isolated pulsars are emitted from relativistic electrons/positrons accelerated in outer magnetospheric accelerators (outergaps) via a curvature radiation mechanism, which has a simple exponential cut-off spectrum. However, many gamma-ray pulsars detected by the Fermi LAT (Large Area Telescope) cannot be fitted by simple exponential cut-off spectrum, and instead a sub-exponential is more appropriate. It is proposed that the realistic outergaps are non-stationary, and that the observed spectrum is a superposition of different stationary states that are controlled by the currents injected from the inner and outer boundaries. The Vela and Geminga pulsars have the largest fluxes among all targets observed, which allows us to carry out very detailed phase-resolved spectral analysis. We have divided the Vela and Geminga pulsars into 19 (the off pulse of Vela was not included) and 33 phase bins, respectively. We find that most phase resolved spectra still cannot be fitted by a simple exponential spectrum: in fact, a sub-exponential spectrum is necessary. We conclude that non-stationary states exist even down to the very fine phase bins.

Beta/gamma and alpha backgrounds in CRESST-II Phase 2

DOE Office of Scientific and Technical Information (OSTI.GOV)

Strauss, R.; Angloher, G.; Ferreiro Iachellini, N.

2015-06-01

The experiment CRESST-II aims at the detection of dark matter with scintillating CaWO{sub 4} crystals operated as cryogenic detectors. Recent results on spin-independent WIMP-nucleon scattering from the CRESST-II Phase 2 allowed to probe a new region of parameter space for WIMP masses below 3 GeV/c{sup 2}. This sensitivity was achieved after background levels were reduced significantly. We present extensive background studies of a CaWO{sub 4} crystal, called TUM40, grown at the Technische Universität München. The average beta/gamma rate of 3.51/[kg keV day] (1-40 keV) and the total intrinsic alpha activity from natural decay chains of 3.08±0.04 mBq/kg are the lowestmore » reported for CaWO{sub 4} detectors. Contributions from cosmogenic activation, surface-alpha decays, external radiation and intrinsic alpha/beta emitters are investigated in detail. A Monte-Carlo based background decomposition allows to identify the origin of the majority of beta/gamma events in the energy region relevant for dark matter search.« less

Multiwavelength Observations of the Blazar BL Lacertae: A New Fast TeV Gamma-Ray Flare

NASA Astrophysics Data System (ADS)

Abeysekara, A. U.; Benbow, W.; Bird, R.; Brantseg, T.; Brose, R.; Buchovecky, M.; Buckley, J. H.; Bugaev, V.; Connolly, M. P.; Cui, W.; Daniel, M. K.; Falcone, A.; Feng, Q.; Finley, J. P.; Fortson, L.; Furniss, A.; Gillanders, G. H.; Gunawardhana, I.; Hütten, M.; Hanna, D.; Hervet, O.; Holder, J.; Hughes, G.; Humensky, T. B.; Johnson, C. A.; Kaaret, P.; Kar, P.; Kertzman, M.; Krennrich, F.; Lang, M. J.; Lin, T. T. Y.; McArthur, S.; Moriarty, P.; Mukherjee, R.; O’Brien, S.; Ong, R. A.; Otte, A. N.; Park, N.; Petrashyk, A.; Pohl, M.; Pueschel, E.; Quinn, J.; Ragan, K.; Reynolds, P. T.; Richards, G. T.; Roache, E.; Rulten, C.; Sadeh, I.; Santander, M.; Sembroski, G. H.; Shahinyan, K.; Wakely, S. P.; Weinstein, A.; Wells, R. M.; Wilcox, P.; Williams, D. A.; Zitzer, B.; The VERITAS Collaboration; Jorstad, S. G.; Marscher, A. P.; Lister, M. L.; Kovalev, Y. Y.; Pushkarev, A. B.; Savolainen, T.; Agudo, I.; Molina, S. N.; Gómez, J. L.; Larionov, V. M.; Borman, G. A.; Mokrushina, A. A.; Tornikoski, M.; Lähteenmäki, A.; Chamani, W.; Enestam, S.; Kiehlmann, S.; Hovatta, T.; Smith, P. S.; Pontrelli, P.

2018-04-01

Combined with measurements made by very-long-baseline interferometry, the observations of fast TeV gamma-ray flares probe the structure and emission mechanism of blazar jets. However, only a handful of such flares have been detected to date, and only within the last few years have these flares been observed from lower-frequency-peaked BL Lac objects and flat-spectrum radio quasars. We report on a fast TeV gamma-ray flare from the blazar BL Lacertae observed by the Very Energetic Radiation Imaging Telescope Array System (VERITAS). with a rise time of ∼2.3 hr and a decay time of ∼36 min. The peak flux above 200 GeV is (4.2 ± 0.6) × 10‑6 photon m‑2 s‑1 measured with a 4-minute-binned light curve, corresponding to ∼180% of the flux that is observed from the Crab Nebula above the same energy threshold. Variability contemporaneous with the TeV gamma-ray flare was observed in GeV gamma-ray, X-ray, and optical flux, as well as in optical and radio polarization. Additionally, a possible moving emission feature with superluminal apparent velocity was identified in Very Long Baseline Array observations at 43 GHz, potentially passing the radio core of the jet around the time of the gamma-ray flare. We discuss the constraints on the size, Lorentz factor, and location of the emitting region of the flare, and the interpretations with several theoretical models that invoke relativistic plasma passing stationary shocks.

30 CFR 27.23 - Automatic warning device.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 30 Mineral Resources 1 2014-07-01 2014-07-01 false Automatic warning device. 27.23 Section 27.23... Automatic warning device. (a) An automatic warning device shall be suitably constructed for incorporation in... automatic warning device shall include an alarm signal (audible or colored light), which shall be made to...

30 CFR 27.23 - Automatic warning device.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 30 Mineral Resources 1 2012-07-01 2012-07-01 false Automatic warning device. 27.23 Section 27.23... Automatic warning device. (a) An automatic warning device shall be suitably constructed for incorporation in... automatic warning device shall include an alarm signal (audible or colored light), which shall be made to...

30 CFR 27.23 - Automatic warning device.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Automatic warning device. 27.23 Section 27.23... Automatic warning device. (a) An automatic warning device shall be suitably constructed for incorporation in... automatic warning device shall include an alarm signal (audible or colored light), which shall be made to...

30 CFR 27.23 - Automatic warning device.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 30 Mineral Resources 1 2013-07-01 2013-07-01 false Automatic warning device. 27.23 Section 27.23... Automatic warning device. (a) An automatic warning device shall be suitably constructed for incorporation in... automatic warning device shall include an alarm signal (audible or colored light), which shall be made to...

Applying the new gamma ray imager diagnostic to measurements of runaway electron Bremsstrahlung radiation in the DIII-D Tokamak (invited)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cooper, C. M., E-mail: coopercm@fusion.gat.com; Pace, D. C.; Paz-Soldan, C.

2016-11-15

A new gamma ray imager (GRI) is developed to probe the electron distribution function with 2D spatial resolution during runaway electron (RE) experiments at the DIII-D tokamak. The diagnostic is sensitive to 0.5–100 MeV gamma rays, allowing characterization of the RE distribution function evolution during RE growth and dissipation. The GRI consists of a lead “pinhole camera” mounted on the DIII-D midplane with 123 honeycombed tangential chords 20 cm wide that span the vessel interior. Up to 30 bismuth germanate (BGO) scintillation detectors capture RE bremsstrahlung radiation for Pulse Height Analysis (PHA) capable of discriminating up to 20 000 pulses permore » second. Digital signal processing routines combining shaping filters are performed during PHA to reject noise and record gamma ray energy. The GRI setup and PHA algorithms will be described and initial data from experiments will be presented. A synthetic diagnostic is developed to generate the gamma ray spectrum of a GRI channel given the plasma information and a prescribed distribution function. Magnetic reconstructions of the plasma are used to calculate the angle between every GRI sightline and orient and discriminate gamma rays emitted by a field-aligned RE distribution function.« less

Applying the new gamma ray imager diagnostic to measurements of runaway electron Bremsstrahlung radiation in the DIII-D Tokamak (invited)

DOE PAGES

Cooper, C. M.; Pace, D. C.; Paz-Soldan, C.; ...

2016-08-30

A new gamma ray imager (GRI) is developed to probe the electron distribution function with 2D spatial resolution during runaway electron (RE) experiments at the DIII-D tokamak. The diagnostic is sensitive to 0.5-100 MeV gamma rays, allowing characterization of the RE distribution function evolution during RE growth and dissipation. The GRI consists of a lead "pinhole camera" mounted on the DIII-D midplane with 123 honeycombed tangential chords 20 cm wide that span the vessel interior. Up to 30 bismuth germanate (BGO) scintillation detectors capture RE bremsstrahlung radiation for Pulse Height Analysis (PHA) capable of discriminating up to 20,000 pulses permore » second. Digital signal processing routines combining shaping filters are performed during PHA to reject noise and record gamma ray energy. The GRI setup and PHA algorithms will be described and initial data from experiments will be presented. A synthetic diagnostic is developed to generate the gamma ray spectrum of a GRI channel given the plasma information and a prescribed distribution function. Furthermore, magnetic reconstructions of the plasma are used to calculate the angle between every GRI sightline and orient and discriminate gamma rays emitted by a field-aligned RE distribution function.« less

Neural Bases of Automaticity

ERIC Educational Resources Information Center

Servant, Mathieu; Cassey, Peter; Woodman, Geoffrey F.; Logan, Gordon D.

2018-01-01

Automaticity allows us to perform tasks in a fast, efficient, and effortless manner after sufficient practice. Theories of automaticity propose that across practice processing transitions from being controlled by working memory to being controlled by long-term memory retrieval. Recent event-related potential (ERP) studies have sought to test this…

Reconstructing the Gamma-Ray Photon Optical Depth of the Universe To Z Approx. 4 from Multiwavelength Galaxy Survey Data

NASA Technical Reports Server (NTRS)

Helgason, Kari; Kashlinsky, Alexander

2012-01-01

Reconstructing the Gamma-Ray Photon Optical Depth of the Universe To Z Approx. 4fFrom Multiwavelength Galaxy Survey Data We reconstruct the gamma-ray opacity of the universe out to z approx. < 3–4 using an extensive library of 342 observed galaxy luminosity function (LF) surveys extending to high redshifts .We cover the whole range from UV to mid-IR (0.15–25 micron ) providing for the first time a robust empirical calculation of the gamma gamma optical depth out to several TeV. Here, we use the same database as Helgason et al. where the extragalactic background light was reconstructed from LFs out to 4.5 micron and was shown to recover observed galaxy counts to high accuracy. We extend our earlier library Of LFs to 25micron such that it covers the energy range of pair production with gamma -rays (1) in the entire Fermi/LAT energy range, and (2) at higher TeV energies probed by ground-based Cherenkov telescopes. In the absence of significant contributions to the cosmic diffuse background from unknown populations, such as the putative Population III era sources, the universe appears to be largely transparent to gamma-rays at all Fermi/LAT energies out to z approx.. 2 whereas it becomes opaque to TeV photons already at z approx. < 0.2 and reaching tau approx 10 at z = 1. Comparing with the currently available Fermi/LAT gamma-ray burst and blazar data shows that there is room for significant emissions originating in the first stars era.

Increase in neutrophil Fc gamma receptor I expression following interferon gamma treatment in rheumatoid arthritis.

PubMed Central

Goulding, N J; Knight, S M; Godolphin, J L; Guyre, P M

1992-01-01

The therapeutic potential of interferon gamma (IFN gamma) in a number of disease states is still being explored, but progress is hampered by the lack of a suitable measure of in vivo biological activity. To assess the in vivo biological effects of recombinant human IFN gamma (rhIFN gamma), 14 patients were studied in a randomised, prospective, double blind, placebo controlled trial of this cytokine for the treatment of rheumatoid arthritis. The levels of Fc gamma receptors on peripheral blood neutrophils were measured at baseline and after 21 days of once daily, subcutaneous injections of rhIFN gamma or placebo. An induction of neutrophil Fc gamma receptor type I (Fc gamma RI) was seen in the group of patients receiving recombinant human rhIFN gamma but not in those receiving placebo. No change in the expression of Fc gamma RII or Fc gamma RIII was detected. The amount of induction of Fc gamma RI detected on the neutrophils of patients receiving rhIFN gamma did not correlate with clinical measures of response at either 21 days or at the end of the study (24 weeks). No significant clinical responses were observed in the rhIFN gamma group at these times. These data confirm that the reported in vitro effect of IFN gamma on human neutrophil Fc receptor expression can be reproduced in vivo. PMID:1534001

Increase in neutrophil Fc gamma receptor I expression following interferon gamma treatment in rheumatoid arthritis.

PubMed

Goulding, N J; Knight, S M; Godolphin, J L; Guyre, P M

1992-04-01

The therapeutic potential of interferon gamma (IFN gamma) in a number of disease states is still being explored, but progress is hampered by the lack of a suitable measure of in vivo biological activity. To assess the in vivo biological effects of recombinant human IFN gamma (rhIFN gamma), 14 patients were studied in a randomised, prospective, double blind, placebo controlled trial of this cytokine for the treatment of rheumatoid arthritis. The levels of Fc gamma receptors on peripheral blood neutrophils were measured at baseline and after 21 days of once daily, subcutaneous injections of rhIFN gamma or placebo. An induction of neutrophil Fc gamma receptor type I (Fc gamma RI) was seen in the group of patients receiving recombinant human rhIFN gamma but not in those receiving placebo. No change in the expression of Fc gamma RII or Fc gamma RIII was detected. The amount of induction of Fc gamma RI detected on the neutrophils of patients receiving rhIFN gamma did not correlate with clinical measures of response at either 21 days or at the end of the study (24 weeks). No significant clinical responses were observed in the rhIFN gamma group at these times. These data confirm that the reported in vitro effect of IFN gamma on human neutrophil Fc receptor expression can be reproduced in vivo.

[Sentinel node detection using optonuclear probe (gamma and fluorescence) after green indocyanine and radio-isotope injections].

PubMed

Poumellec, M-A; Dejode, M; Figl, A; Darcourt, J; Haudebourg, J; Sabah, Y; Voury, A; Martaens, A; Barranger, E

2016-04-01

Assess the biopsy's feasibility of the sentinel lymph node biopsy (SLNB) using optonuclear probe after of indocyanine green (ICG) and radio-isotope (RI) injections. Twenty-one patients with a localized breast cancer and unsuspicious axillary nodes underwent a SLNB after both injections of ICG and radio-isotope. One or more SLN were identified on the 21 patients (identification rate of 100%). The median number SLN was 2 (1-3). Twenty SLN were both radio-actives and fluorescents (54.1%), 11 fluorescent only (29.7%) and 6 were only radio-actives (16.2%). Seven patients had a metastatic SLN (8 SLN overall). Among them, only one had a micrometastasic SLN, 5 others had a macrometastatic SLN and one patient had two macrometastatic SLNs. Among the 8 metastatic SLN, 5 were both fluorescent and radioactive, 2 were only fluorescent and 1 was only radioactive. Detection SLN using optonuclear probe after indocyanine green and radio-isotope injections is effective and could be, after validation by randomized trial, a reliable alternative to the blue dye injection for teams who consider that combined detection as the reference. Copyright © 2016 Elsevier Masson SAS. All rights reserved.

Gamma Knife

MedlinePlus

... equipment? How is safety ensured? What is this equipment used for? The Gamma Knife® and its associated ... in size. top of page How does the equipment work? The Gamma Knife® utilizes a technique called ...

Gamma-400 Science Objectives Built on the Current HE Gamma-Ray and CR Results

NASA Technical Reports Server (NTRS)

Moiseev, Alexander; Mitchell, John; Thompson, David

2012-01-01

The main scientific interest of the Russian Gamma-400 team: Observe gamma-rays above approximately 50 GeV with excellent energy and angular resolution with the goals of: (1) Studying the fine spectral structure of the isotropic high-energy gamma-radiation, (2) Attempting to identify the many still-unidentified Fermi-LAT gamma-ray sources. Gamma-400 will likely be the only space-based gamma-ray observatory operating at the end of the decade. In our proposed Gamma-400-LE version, it will substantially improve upon the capabilities of Fermi LAT and AGILE in both LE and HE energy range. Measuring gamma-rays from approx 20 MeV to approx 1 TeV for at least 7 years, Gamma-400-LE will address the topics of dark matter, cosmic ray origin and propagation, neutron stars, flaring pulsars, black holes, AGNs, GRBs, and actively participate in multiwavelength campaigns.

46 CFR 52.01-10 - Automatic controls.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 2 2013-10-01 2013-10-01 false Automatic controls. 52.01-10 Section 52.01-10 Shipping... Requirements § 52.01-10 Automatic controls. (a) Each main boiler must meet the special requirements for automatic safety controls in § 62.35-20(a)(1) of this chapter. (b) Each automatically controlled auxiliary...

46 CFR 52.01-10 - Automatic controls.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 2 2010-10-01 2010-10-01 false Automatic controls. 52.01-10 Section 52.01-10 Shipping... Requirements § 52.01-10 Automatic controls. (a) Each main boiler must meet the special requirements for automatic safety controls in § 62.35-20(a)(1) of this chapter. (b) Each automatically controlled auxiliary...

46 CFR 52.01-10 - Automatic controls.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 46 Shipping 2 2014-10-01 2014-10-01 false Automatic controls. 52.01-10 Section 52.01-10 Shipping... Requirements § 52.01-10 Automatic controls. (a) Each main boiler must meet the special requirements for automatic safety controls in § 62.35-20(a)(1) of this chapter. (b) Each automatically controlled auxiliary...

46 CFR 52.01-10 - Automatic controls.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 46 Shipping 2 2012-10-01 2012-10-01 false Automatic controls. 52.01-10 Section 52.01-10 Shipping... Requirements § 52.01-10 Automatic controls. (a) Each main boiler must meet the special requirements for automatic safety controls in § 62.35-20(a)(1) of this chapter. (b) Each automatically controlled auxiliary...

46 CFR 52.01-10 - Automatic controls.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 2 2011-10-01 2011-10-01 false Automatic controls. 52.01-10 Section 52.01-10 Shipping... Requirements § 52.01-10 Automatic controls. (a) Each main boiler must meet the special requirements for automatic safety controls in § 62.35-20(a)(1) of this chapter. (b) Each automatically controlled auxiliary...

Ultrafast scanning probe microscopy

DOEpatents

Weiss, S.; Chemla, D.S.; Ogletree, D.F.; Botkin, D.

1995-05-16

An ultrafast scanning probe microscopy method is described for achieving subpicosecond-temporal resolution and submicron-spatial resolution of an observation sample. In one embodiment of the present claimed invention, a single short optical pulse is generated and is split into first and second pulses. One of the pulses is delayed using variable time delay means. The first pulse is then directed at an observation sample located proximate to the probe of a scanning probe microscope. The scanning probe microscope produces probe-sample signals indicative of the response of the probe to characteristics of the sample. The second pulse is used to modulate the probe of the scanning probe microscope. The time delay between the first and second pulses is then varied. The probe-sample response signal is recorded at each of the various time delays created between the first and second pulses. The probe-sample response signal is then plotted as a function of time delay to produce a cross-correlation of the probe sample response. In so doing, the present invention provides simultaneous subpicosecond-temporal resolution and submicron-spatial resolution of the sample. 6 Figs.

Genomic sequences of murine gamma B- and gamma C-crystallin-encoding genes: promoter analysis and complete evolutionary pattern of mouse, rat and human gamma-crystallins.

PubMed

Graw, J; Liebstein, A; Pietrowski, D; Schmitt-John, T; Werner, T

1993-12-22

The murine genes, gamma B-cry and gamma C-cry, encoding the gamma B- and gamma C-crystallins, were isolated from a genomic DNA library. The complete nucleotide (nt) sequences of both genes were determined from 661 and 711 bp, respectively, upstream from the first exon to the corresponding polyadenylation sites, comprising more than 2650 and 2890 bp, respectively. The new sequences were compared to the partial cDNA sequences available for the murine gamma B-cry and gamma C-cry, as well as to the corresponding genomic sequences from rat and man, at both the nt and predicted amino acid (aa) sequence levels. In the gamma B-cry promoter region, a canonical CCAAT-box, a TATA-box, putative NF-I and C/EBP sites were detected. An R-repeat is inserted 366 bp upstream from the transcription start point. In contrast, the gamma C-cry promoter does not contain a CCAAT-box, but some other putative binding sites for transcription factors (AP-2, UBP-1, LBP-1) were located by computer analysis. The promoter regions of all six gamma-cry from mouse, rat and human, except human psi gamma F-cry, were analyzed for common sequence elements. A complex sequence element of about 70-80 bp was found in the proximal promoter, which contains a gamma-cry-specific and almost invariant sequence (crygpel) of 14 nt, and ends with the also invariant TATA-box. Within the complex sequence element, a minimum of three further features specific for the gamma A-, gamma B- and gamma D/E/F-cry genes can be defined, at least two of which were recently shown to be functional. In addition to these four sequence elements, a subtype-specific structure of inverted repeats with different-sized spacers can be deduced from the multiple sequence alignment. A phylogenetic analysis based on the promoter region, as well as the complete exon 3 of all gamma-cry from mouse, rat and man, suggests separation of only five gamma-cry subtypes (gamma A-, gamma B-, gamma C-, gamma D- and gamma E/F-cry) prior to species separation.

Predicting diffusion paths and interface motion in gamma/gamma + beta, Ni-Cr-Al diffusion couples

NASA Technical Reports Server (NTRS)

Nesbitt, J. A.; Heckel, R. W.

1987-01-01

A simplified model has been developed to predict Beta recession and diffusion paths in ternary gamma/gamma + beta diffusion couples (gamma:fcc, beta: NiAl structure). The model was tested by predicting beta recession and diffusion paths for four gamma/gamma + beta, Ni-Cr-Al couples annealed for 100 hours at 1200 C. The model predicted beta recession within 20 percent of that measured for each of the couples. The model also predicted shifts in the concentration of the gamma phase at the gamma/gamma + beta interface within 2 at. pct Al and 6 at. pct Cr of that measured in each of the couples. A qualitative explanation based on simple kinetic and mass balance arguments has been given which demonstrates the necessity for diffusion in the two-phase region of certain gamma/gamma + beta, Ni-Cr-Al couples.

Three-dimensional reconstruction of neutron, gamma-ray, and x-ray sources using spherical harmonic decomposition

NASA Astrophysics Data System (ADS)

Volegov, P. L.; Danly, C. R.; Fittinghoff, D.; Geppert-Kleinrath, V.; Grim, G.; Merrill, F. E.; Wilde, C. H.

2017-11-01

Neutron, gamma-ray, and x-ray imaging are important diagnostic tools at the National Ignition Facility (NIF) for measuring the two-dimensional (2D) size and shape of the neutron producing region, for probing the remaining ablator and measuring the extent of the DT plasmas during the stagnation phase of Inertial Confinement Fusion implosions. Due to the difficulty and expense of building these imagers, at most only a few two-dimensional projections images will be available to reconstruct the three-dimensional (3D) sources. In this paper, we present a technique that has been developed for the 3D reconstruction of neutron, gamma-ray, and x-ray sources from a minimal number of 2D projections using spherical harmonics decomposition. We present the detailed algorithms used for this characterization and the results of reconstructed sources from experimental neutron and x-ray data collected at OMEGA and NIF.

Comparison of gamma-gamma Phase Coarsening Responses of Three Powder Metal Disk Superalloys

NASA Technical Reports Server (NTRS)

Gabb, T. P.; Gayda, J.; Johnson, D. F.; MacKay, R. A.; Rogers, R. B.; Sudbrack, C. K.; Garg, A.; Locci, I. E.; Semiatin, S. L.; Kang, E.

2016-01-01

The phase microstructures of several powder metal (PM) disk superalloys were quantitatively evaluated. Contents, chemistries, and lattice parameters of gamma and gamma strengthening phase were determined for conventionally heat treated Alloy 10, LSHR, and ME3 superalloys, after electrolytic phase extractions. Several of long term heat treatments were then performed, to allow quantification of the precipitation, content, and size distribution of gamma at a long time interval to approximate equilibrium conditions. Additional coarsening heat treatments were performed at multiple temperatures and shorter time intervals, to allow quantification of the precipitation, contents and size distributions of gamma at conditions diverging from equilibrium. Modest differences in gamma and gamma lattice parameters and their mismatch were observed among the alloys, which varied with heat treatment. Yet, gamma coarsening rates were very similar for all three alloys in the heat treatment conditions examined. Alloy 10 had higher gamma dissolution and formation temperatures than LSHR and ME3, but a lower lattice mismatch, which was slightly positive for all three alloys at room temperature. The gamma precipitates of Alloy 10 appeared to remain coherent at higher temperatures than for LSHR and ME3. Higher coarsening rates were observed for gamma precipitates residing along grain boundaries than for those within grains in all three alloys, during slow-moderate quenching from supersolvus solution heat treatments, and during aging at temperatures of 843 C and higher.

High temperature probe

DOEpatents

Swan, Raymond A.

1994-01-01

A high temperature probe for sampling, for example, smokestack fumes, and is able to withstand temperatures of 3000.degree. F. The probe is constructed so as to prevent leakage via the seal by placing the seal inside the water jacket whereby the seal is not exposed to high temperature, which destroys the seal. The sample inlet of the probe is also provided with cooling fins about the area of the seal to provide additional cooling to prevent the seal from being destroyed. Also, a heated jacket is provided for maintaining the temperature of the gas being tested as it passes through the probe. The probe includes pressure sensing means for determining the flow velocity of an efficient being sampled. In addition, thermocouples are located in various places on the probe to monitor the temperature of the gas passing there through.

SU-E-J-205: Monte Carlo Modeling of Ultrasound Probes for Real-Time Ultrasound Image-Guided Radiotherapy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hristov, D; Schlosser, J; Bazalova, M

2014-06-01

Purpose: To quantify the effect of ultrasound (US) probe beam attenuation for radiation therapy delivered under real-time US image guidance by means of Monte Carlo (MC) simulations. Methods: MC models of two Philips US probes, an X6-1 matrix-array transducer and a C5-2 curved-array transducer, were built based on their CT images in the EGSnrc BEAMnrc and DOSXYZnrc codes. Due to the metal parts, the probes were scanned in a Tomotherapy machine with a 3.5 MV beam. Mass densities in the probes were assigned based on an electron density calibration phantom consisting of cylinders with mass densities between 0.2–8.0 g/cm{sup 3}.more » Beam attenuation due to the probes was measured in a solid water phantom for a 6 MV and 15 MV 15x15 cm{sup 2} beam delivered on a Varian Trilogy linear accelerator. The dose was measured with the PTW-729 ionization chamber array at two depths and compared to MC simulations. The extreme case beam attenuation expected in robotic US image guided radiotherapy for probes in upright position was quantified by means of MC simulations. Results: The 3.5 MV CT number to mass density calibration curve was found to be linear with R{sup 2} > 0.99. The maximum mass densities were 4.6 and 4.2 g/cm{sup 3} in the C5-2 and X6-1 probe, respectively. Gamma analysis of the simulated and measured doses revealed that over 98% of measurement points passed the 3%/3mm criteria for both probes and measurement depths. The extreme attenuation for probes in upright position was found to be 25% and 31% for the C5-2 and X6-1 probe, respectively, for both 6 and 15 MV beams at 10 cm depth. Conclusion: MC models of two US probes used for real-time image guidance during radiotherapy have been built. As a Result, radiotherapy treatment planning with the imaging probes in place can now be performed. J Schlosser is an employee of SoniTrack Systems, Inc. D Hristov has financial interest in SoniTrack Systems, Inc.« less

Probe tip heating assembly

DOE Office of Scientific and Technical Information (OSTI.GOV)

Schmitz, Roger William; Oh, Yunje

A heating assembly configured for use in mechanical testing at a scale of microns or less. The heating assembly includes a probe tip assembly configured for coupling with a transducer of the mechanical testing system. The probe tip assembly includes a probe tip heater system having a heating element, a probe tip coupled with the probe tip heater system, and a heater socket assembly. The heater socket assembly, in one example, includes a yoke and a heater interface that form a socket within the heater socket assembly. The probe tip heater system, coupled with the probe tip, is slidably receivedmore » and clamped within the socket.« less

Atmospheric entry probes for outer planet exploration. Outer planet entry probe technical summary

NASA Technical Reports Server (NTRS)

1974-01-01

The use of unmanned space probes for investigating the conditions existing on and around the outer planets of the solar system is discussed. The subjects included in the report are: (1) the design of a common entry probe for outer planet missions, (2) the significant trades related to the development of a common probe design, (3) the impact of bus selection on probe design, (4) the impact of probe requirements on bus modifications, and (5) the key technology elements recommended for advanced development. Drawings and illustrations of typical probes are included to show the components and systems used in the space probes.

Toward real-time quantification of fluorescence molecular probes using target/background ratio for guiding biopsy and endoscopic therapy of esophageal neoplasia.

PubMed

Jiang, Yang; Gong, Yuanzheng; Rubenstein, Joel H; Wang, Thomas D; Seibel, Eric J

2017-04-01

Multimodal endoscopy using fluorescence molecular probes is a promising method of surveying the entire esophagus to detect cancer progression. Using the fluorescence ratio of a target compared to a surrounding background, a quantitative value is diagnostic for progression from Barrett's esophagus to high-grade dysplasia (HGD) and esophageal adenocarcinoma (EAC). However, current quantification of fluorescent images is done only after the endoscopic procedure. We developed a Chan-Vese-based algorithm to segment fluorescence targets, and subsequent morphological operations to generate background, thus calculating target/background (T/B) ratios, potentially to provide real-time guidance for biopsy and endoscopic therapy. With an initial processing speed of 2 fps and by calculating the T/B ratio for each frame, our method provides quasireal-time quantification of the molecular probe labeling to the endoscopist. Furthermore, an automatic computer-aided diagnosis algorithm can be applied to the recorded endoscopic video, and the overall T/B ratio is calculated for each patient. The receiver operating characteristic curve was employed to determine the threshold for classification of HGD/EAC using leave-one-out cross-validation. With 92% sensitivity and 75% specificity to classify HGD/EAC, our automatic algorithm shows promising results for a surveillance procedure to help manage esophageal cancer and other cancers inspected by endoscopy.

Optical probe

DOEpatents

Hencken, Kenneth; Flower, William L.

1999-01-01

A compact optical probe is disclosed particularly useful for analysis of emissions in industrial environments. The instant invention provides a geometry for optically-based measurements that allows all optical components (source, detector, rely optics, etc.) to be located in proximity to one another. The geometry of the probe disclosed herein provides a means for making optical measurements in environments where it is difficult and/or expensive to gain access to the vicinity of a flow stream to be measured. Significantly, the lens geometry of the optical probe allows the analysis location within a flow stream being monitored to be moved while maintaining optical alignment of all components even when the optical probe is focused on a plurality of different analysis points within the flow stream.

ADMAP (automatic data manipulation program)

NASA Technical Reports Server (NTRS)

Mann, F. I.

1971-01-01

Instructions are presented on the use of ADMAP, (automatic data manipulation program) an aerospace data manipulation computer program. The program was developed to aid in processing, reducing, plotting, and publishing electric propulsion trajectory data generated by the low thrust optimization program, HILTOP. The program has the option of generating SC4020 electric plots, and therefore requires the SC4020 routines to be available at excution time (even if not used). Several general routines are present, including a cubic spline interpolation routine, electric plotter dash line drawing routine, and single parameter and double parameter sorting routines. Many routines are tailored for the manipulation and plotting of electric propulsion data, including an automatic scale selection routine, an automatic curve labelling routine, and an automatic graph titling routine. Data are accepted from either punched cards or magnetic tape.

Oscillatory EEG dynamics underlying automatic chunking during sentence processing.

PubMed

Bonhage, Corinna E; Meyer, Lars; Gruber, Thomas; Friederici, Angela D; Mueller, Jutta L

2017-05-15

Sentences are easier to remember than random word sequences, likely because linguistic regularities facilitate chunking of words into meaningful groups. The present electroencephalography study investigated the neural oscillations modulated by this so-called sentence superiority effect during the encoding and maintenance of sentence fragments versus word lists. We hypothesized a chunking-related modulation of neural processing during the encoding and retention of sentences (i.e., sentence fragments) as compared to word lists. Time-frequency analysis revealed a two-fold oscillatory pattern for the memorization of sentences: Sentence encoding was accompanied by higher delta amplitude (4Hz), originating both from regions processing syntax as well as semantics (bilateral superior/middle temporal regions and fusiform gyrus). Subsequent sentence retention was reflected in decreased theta (6Hz) and beta/gamma (27-32Hz) amplitude instead. Notably, whether participants simply read or properly memorized the sentences did not impact chunking-related activity during encoding. Therefore, we argue that the sentence superiority effect is grounded in highly automatized language processing mechanisms, which generate meaningful memory chunks irrespective of task demands. Copyright © 2017 Elsevier Inc. All rights reserved.

Preventing probe induced topography correlated artifacts in Kelvin Probe Force Microscopy.

PubMed

Polak, Leo; Wijngaarden, Rinke J

2016-12-01

Kelvin Probe Force Microscopy (KPFM) on samples with rough surface topography can be hindered by topography correlated artifacts. We show that, with the proper experimental configuration and using homogeneously metal coated probes, we are able to obtain amplitude modulation (AM) KPFM results on a gold coated sample with rough topography that are free from such artifacts. By inducing tip inhomogeneity through contact with the sample, clear potential variations appear in the KPFM image, which correlate with the surface topography and, thus, are probe induced artifacts. We find that switching to frequency modulation (FM) KPFM with such altered probes does not remove these artifacts. We also find that the induced tip inhomogeneity causes a lift height dependence of the KPFM measurement, which can therefore be used as a check for the presence of probe induced topography correlated artifacts. We attribute the observed effects to a work function difference between the tip and the rest of the probe and describe a model for such inhomogeneous probes that predicts lift height dependence and topography correlated artifacts for both AM and FM-KPFM methods. This work demonstrates that using a probe with a homogeneous work function and preventing tip changes is essential for KPFM on non-flat samples. From the three investigated probe coatings, PtIr, Au and TiN, the latter appears to be the most suitable, because of its better resistance against coating damage. Copyright © 2016 Elsevier B.V. All rights reserved.

The gamma-ray observatory

NASA Technical Reports Server (NTRS)

1991-01-01

An overview is given of the Gamma Ray Observatory (GRO) mission. Detection of gamma rays and gamma ray sources, operations using the Space Shuttle, and instruments aboard the GRO, including the Burst and Transient Source Experiment (BATSE), the Oriented Scintillation Spectrometer Experiment (OSSE), the Imaging Compton Telescope (COMPTEL), and the Energetic Gamma Ray Experiment Telescope (EGRET) are among the topics surveyed.

High-frequency gamma oscillations coexist with low-frequency gamma oscillations in the rat visual cortex in vitro.

PubMed

Oke, Olaleke O; Magony, Andor; Anver, Himashi; Ward, Peter D; Jiruska, Premysl; Jefferys, John G R; Vreugdenhil, Martin

2010-04-01

Synchronization of neuronal activity in the visual cortex at low (30-70 Hz) and high gamma band frequencies (> 70 Hz) has been associated with distinct visual processes, but mechanisms underlying high-frequency gamma oscillations remain unknown. In rat visual cortex slices, kainate and carbachol induce high-frequency gamma oscillations (fast-gamma; peak frequency approximately 80 Hz at 37 degrees C) that can coexist with low-frequency gamma oscillations (slow-gamma; peak frequency approximately 50 Hz at 37 degrees C) in the same column. Current-source density analysis showed that fast-gamma was associated with rhythmic current sink-source sequences in layer III and slow-gamma with rhythmic current sink-source sequences in layer V. Fast-gamma and slow-gamma were not phase-locked. Slow-gamma power fluctuations were unrelated to fast-gamma power fluctuations, but were modulated by the phase of theta (3-8 Hz) oscillations generated in the deep layers. Fast-gamma was spatially less coherent than slow-gamma. Fast-gamma and slow-gamma were dependent on gamma-aminobutyric acid (GABA)(A) receptors, alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors and gap-junctions, their frequencies were reduced by thiopental and were weakly dependent on cycle amplitude. Fast-gamma and slow-gamma power were differentially modulated by thiopental and adenosine A(1) receptor blockade, and their frequencies were differentially modulated by N-methyl-D-aspartate (NMDA) receptors, GluK1 subunit-containing receptors and persistent sodium currents. Our data indicate that fast-gamma and slow-gamma both depend on and are paced by recurrent inhibition, but have distinct pharmacological modulation profiles. The independent co-existence of fast-gamma and slow-gamma allows parallel processing of distinct aspects of vision and visual perception. The visual cortex slice provides a novel in vitro model to study cortical high-frequency gamma oscillations.

A method to describe inelastic gamma field distribution in neutron gamma density logging.

PubMed

Zhang, Feng; Zhang, Quanying; Liu, Juntao; Wang, Xinguang; Wu, He; Jia, Wenbao; Ti, Yongzhou; Qiu, Fei; Zhang, Xiaoyang

2017-11-01

Pulsed neutron gamma density logging (NGD) is of great significance for radioprotection and density measurement in LWD, however, the current methods have difficulty in quantitative calculation and single factor analysis for the inelastic gamma field distribution. In order to clarify the NGD mechanism, a new method is developed to describe the inelastic gamma field distribution. Based on the fast-neutron scattering and gamma attenuation, the inelastic gamma field distribution is characterized by the inelastic scattering cross section, fast-neutron scattering free path, formation density and other parameters. And the contribution of formation parameters on the field distribution is quantitatively analyzed. The results shows the contribution of density attenuation is opposite to that of inelastic scattering cross section and fast-neutron scattering free path. And as the detector-spacing increases, the density attenuation gradually plays a dominant role in the gamma field distribution, which means large detector-spacing is more favorable for the density measurement. Besides, the relationship of density sensitivity and detector spacing was studied according to this gamma field distribution, therefore, the spacing of near and far gamma ray detector is determined. The research provides theoretical guidance for the tool parameter design and density determination of pulsed neutron gamma density logging technique. Copyright © 2017 Elsevier Ltd. All rights reserved.

Towards a global network of gamma-ray detector calibration facilities

NASA Astrophysics Data System (ADS)

Tijs, Marco; Koomans, Ronald; Limburg, Han

2016-09-01

Gamma-ray logging tools are applied worldwide. At various locations, calibration facilities are used to calibrate these gamma-ray logging systems. Several attempts have been made to cross-correlate well known calibration pits, but this cross-correlation does not include calibration facilities in Europe or private company calibration facilities. Our aim is to set-up a framework that gives the possibility to interlink all calibration facilities worldwide by using `tools of opportunity' - tools that have been calibrated in different calibration facilities, whether this usage was on a coordinated basis or by coincidence. To compare the measurement of different tools, it is important to understand the behaviour of the tools in the different calibration pits. Borehole properties, such as diameter, fluid, casing and probe diameter strongly influence the outcome of gamma-ray borehole logging. Logs need to be properly calibrated and compensated for these borehole properties in order to obtain in-situ grades or to do cross-hole correlation. Some tool providers provide tool-specific correction curves for this purpose. Others rely on reference measurements against sources of known radionuclide concentration and geometry. In this article, we present an attempt to set-up a framework for transferring `local' calibrations to be applied `globally'. This framework includes corrections for any geometry and detector size to give absolute concentrations of radionuclides from borehole measurements. This model is used to compare measurements in the calibration pits of Grand Junction, located in the USA; Adelaide (previously known as AMDEL), located in Adelaide Australia; and Stonehenge, located at Medusa Explorations BV in the Netherlands.

Variation in electrical properties of gamma irradiated cadmium selenate nanowires

NASA Astrophysics Data System (ADS)

Chauhan, R. P.; Rana, Pallavi; Narula, Chetna; Panchal, Suresh; Choudhary, Ritika

2016-07-01

Preparation of low-dimensional materials attracts more and more interest in the last few years, mainly due to the wide field of potential commercial applications ranging from life sciences, medicine and biotechnology to communication and electronics. One-dimensional systems are the smallest dimension structures that can be used for efficient transport of electrons and thus expected to be critical to the function and integration of nanoscale devices. Nanowires with well controlled morphology and extremely high aspect ratio can be obtained by replicating a nanoporous polymer ion-track membrane with cylindrical pores of controlled dimensions. With this technique, materials can be deposited within the pores of the membrane by electrochemical reduction of the desired ion. In the present study, cadmium selenate nanowires were synthesized potentiostatically via template method. These synthesized nanowires were then exposed to gamma rays by using a 60Co source at the Inter University Accelerator Centre, New Delhi, India. Structural, morphological, electrical and elemental characterizations were made in order to analyze the effect of gamma irradiation on the synthesized nanowires. I-V measurements of cadmium selenate nanowires, before and after irradiation were made with the help of Keithley 2400 source meter and Ecopia probe station. A significant change in the electrical conductivity of cadmium selenate nanowires was found after gamma irradiation. The crystallography of the synthesized nanowires was also studied using a Rigaku X-ray diffractrometer equipped with Cu-Kα radiation. XRD patterns of irradiated samples showed no variation in the peak positions or phase change.

Automatic ball bar for a coordinate measuring machine

DOEpatents

Jostlein, H.

1997-07-15

An automatic ball bar for a coordinate measuring machine determines the accuracy of a coordinate measuring machine having at least one servo drive. The apparatus comprises a first and second gauge ball connected by a telescoping rigid member. The rigid member includes a switch such that inward radial movement of the second gauge ball relative to the first gauge ball causes activation of the switch. The first gauge ball is secured in a first magnetic socket assembly in order to maintain the first gauge ball at a fixed location with respect to the coordinate measuring machine. A second magnetic socket assembly secures the second gauge ball to the arm or probe holder of the coordinate measuring machine. The second gauge ball is then directed by the coordinate measuring machine to move radially inward from a point just beyond the length of the ball bar until the switch is activated. Upon switch activation, the position of the coordinate measuring machine is determined and compared to known ball bar length such that the accuracy of the coordinate measuring machine can be determined. 5 figs.

Automatic ball bar for a coordinate measuring machine

DOEpatents

Jostlein, Hans

1997-01-01

An automatic ball bar for a coordinate measuring machine determines the accuracy of a coordinate measuring machine having at least one servo drive. The apparatus comprises a first and second gauge ball connected by a telescoping rigid member. The rigid member includes a switch such that inward radial movement of the second gauge ball relative to the first gauge ball causes activation of the switch. The first gauge ball is secured in a first magnetic socket assembly in order to maintain the first gauge ball at a fixed location with respect to the coordinate measuring machine. A second magnetic socket assembly secures the second gauge ball to the arm or probe holder of the coordinate measuring machine. The second gauge ball is then directed by the coordinate measuring machine to move radially inward from a point just beyond the length of the ball bar until the switch is activated. Upon switch activation, the position of the coordinate measuring machine is determined and compared to known ball bar length such that the accuracy of the coordinate measuring machine can be determined.

Global spectral UV-radiometer with automatic shadow band.

PubMed

Rosales, Alejandro; Pedroni, Jorge V; Tocho, Jorge O

2006-01-01

A solar radiometer (GUV-511 C, Biospherical Instruments Inc., San Diego, CA) with four UV channels has been operating at Trelew (43.2 degrees S, 65.3 degrees W), Argentina, since the austral spring of 1997. The instrument provides global (direct + diffuse) irradiance on the horizontal plane year-round, with a 1 min period. On 1 January 1999, an automatic shadow band was added to calculate diffuse and direct radiation. The period of the measurements was increased to 2 min to keep the same signal to noise (S:N) ratio. Once the direct radiation values were available for the 305 nm and 320 nm spectral bands, the total ozone value was calculated and results were compared with data provided by the U.S. National Aeronautics and Space Administration for the Total Ozone Mapping Spectrometer (TOMS) on the Earth Probe satellite. Results show a root-mean-square (RMS) deviation within 4% compared with that of TOMS, so the quality of results is considered to be quite good. The importance of regular calibration to maintain long-term accuracy is stressed.

The igmspec database of public spectra probing the intergalactic medium

NASA Astrophysics Data System (ADS)

Prochaska, J. X.

2017-04-01

We describe v02 of igmspec, a database of publicly available ultraviolet, optical, and near-infrared spectra that probe the intergalactic medium (IGM). This database, a child of the specdb repository in the specdb github organization, comprises 403 277 unique sources and 434 686 spectra obtained with the world's greatest observatories. All of these data are distributed in a single ≈ 25GB HDF5 file maintained at the University of California Observatories and the University of California, Santa Cruz. The specdb software package includes Python scripts and modules for searching the source catalog and spectral datasets, and software links to the linetools package for spectral analysis. The repository also includes software to generate private spectral datasets that are compliant with International Virtual Observatory Alliance (IVOA) protocols and a Python-based interface for IVOA Simple Spectral Access queries. Future versions of igmspec will ingest other sources (e.g. gamma-ray burst afterglows) and other surveys as they become publicly available. The overall goal is to include every spectrum that effectively probes the IGM. Future databases of specdb may include publicly available galaxy spectra (exgalspec) and published supernovae spectra (snspec). The community is encouraged to join the effort on github: https://github.com/specdb.

FIRST DETECTION OF >100 MeV GAMMA-RAYS ASSOCIATED WITH A BEHIND-THE-LIMB SOLAR FLARE

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pesce-Rollins, M.; Omodei, N.; Petrosian, V.

2015-06-01

We report the first detection of >100 MeV gamma-rays associated with a behind-the-limb solar flare, which presents a unique opportunity to probe the underlying physics of high-energy flare emission and particle acceleration. On 2013 October 11 a GOES M1.5 class solar flare occurred ∼9.°9 behind the solar limb as observed by STEREO-B. RHESSI observed hard X-ray (HXR) emission above the limb, most likely from the flare loop-top, as the footpoints were occulted. Surprisingly, the Fermi Large Area Telescope (LAT) detected >100 MeV gamma-rays for ∼30 minutes with energies up to 3 GeV. The LAT emission centroid is consistent with themore » RHESSI HXR source, but its uncertainty does not constrain the source to be located there. The gamma-ray spectra can be adequately described by bremsstrahlung radiation from relativistic electrons having a relatively hard power-law (PL) spectrum with a high-energy exponential cutoff, or by the decay of pions produced by accelerated protons and ions with an isotropic pitch-angle distribution and a PL spectrum with a number index of ∼3.8. We show that high optical depths rule out the gamma-rays originating from the flare site and a high-corona trap model requires very unusual conditions, so a scenario in which some of the particles accelerated by the CME shock travel to the visible side of the Sun to produce the observed gamma-rays may be at work.« less

First detection of >100 MeV gamma-rays associated with a behind-the-limb solar flare

DOE PAGES

Pesce-Rollins, Melissa; Omodei, Nicola; Petrosian, V.; ...

2015-05-28

Here, we report the first detection of >100 MeV gamma-rays associated with a behind-the-limb solar flare, which presents a unique opportunity to probe the underlying physics of high-energy flare emission and particle acceleration. On 2013 October 11 a GOES M1.5 class solar flare occurred ~9°.9 behind the solar limb as observed by STEREO-B. RHESSI observed hard X-ray (HXR) emission above the limb, most likely from the flare loop-top, as the footpoints were occulted. Surprisingly, the Fermi Large Area Telescope (LAT) detected >100 MeV gamma-rays for ~30 minutes with energies up to 3 GeV. The LAT emission centroid is consistent withmore » the RHESSI HXR source, but its uncertainty does not constrain the source to be located there. The gamma-ray spectra can be adequately described by bremsstrahlung radiation from relativistic electrons having a relatively hard power-law (PL) spectrum with a high-energy exponential cutoff, or by the decay of pions produced by accelerated protons and ions with an isotropic pitch-angle distribution and a PL spectrum with a number index of ~3.8. Furthermore, we show that high optical depths rule out the gamma-rays originating from the flare site and a high-corona trap model requires very unusual conditions, so a scenario in which some of the particles accelerated by the CME shock travel to the visible side of the Sun to produce the observed gamma-rays may be at work.« less

Real-time electrochemical LAMP: a rational comparative study of different DNA intercalating and non-intercalating redox probes.

PubMed

Martin, Alexandra; Bouffier, Laurent; Grant, Kathryn B; Limoges, Benoît; Marchal, Damien

2016-06-20

We present a comparative study of ten redox-active probes for use in real-time electrochemical loop-mediated isothermal amplification (LAMP). Our main objectives were to establish the criteria that need to be fulfilled for minimizing some of the current limitations of the technique and to provide future guidelines in the search for ideal redox reporters. To ensure a reliable comparative study, each redox probe was tested under similar conditions using the same LAMP reaction and the same entirely automatized custom-made real-time electrochemical device (designed for electrochemically monitoring in real-time and in parallel up to 48 LAMP samples). Electrochemical melt curve analyses were recorded immediately at the end of each LAMP reaction. Our results show that there are a number of intercalating and non-intercalating redox compounds suitable for real-time electrochemical LAMP and that the best candidates are those able to intercalate strongly into ds-DNA but not too much to avoid inhibition of the LAMP reaction. The strongest intercalating redox probes were finally shown to provide higher LAMP sensitivity, speed, greater signal amplitude, and cleaner-cut DNA melting curves than the non-intercalating molecules.

The gamma cycle.

PubMed

Fries, Pascal; Nikolić, Danko; Singer, Wolf

2007-07-01

Activated neuronal groups typically engage in rhythmic synchronization in the gamma-frequency range (30-100 Hz). Experimental and modeling studies demonstrate that each gamma cycle is framed by synchronized spiking of inhibitory interneurons. Here, we review evidence suggesting that the resulting rhythmic network inhibition interacts with excitatory input to pyramidal cells such that the more excited cells fire earlier in the gamma cycle. Thus, the amplitude of excitatory drive is recoded into phase values of discharges relative to the gamma cycle. This recoding enables transmission and read out of amplitude information within a single gamma cycle without requiring rate integration. Furthermore, variation of phase relations can be exploited to facilitate or inhibit exchange of information between oscillating cell assemblies. The gamma cycle could thus serve as a fundamental computational mechanism for the implementation of a temporal coding scheme that enables fast processing and flexible routing of activity, supporting fast selection and binding of distributed responses. This review is part of the INMED/TINS special issue Physiogenic and pathogenic oscillations: the beauty and the beast, based on presentations at the annual INMED/TINS symposium (http://inmednet.com).

The Advanced Gamma-ray Imaging System (AGIS)-Science Highlights

NASA Astrophysics Data System (ADS)

Buckley, J.; Coppi, P.; Digel, S.; Funk, S.; Krawczynski, H.; Krennrich, F.; Pohl, M.; Romani, R.; Vassiliev, V.

2008-12-01

The Advanced Gamma-ray Imaging System (AGIS), a future gamma-ray telescope consisting of an array of ~50 atmospheric Cherenkov telescopes distributed over an area of ~1 km2, will provide a powerful new tool for exploring the high-energy universe. The order-of-magnitude increase in sensitivity and improved angular resolution could provide the first detailed images of γ-ray emission from other nearby galaxies or galaxy clusters. The large effective area will provide unprecedented sensitivity to short transients (such as flares from AGNs and GRBs) probing both intrinsic spectral variability (revealing the details of the acceleration mechanism and geometry) as well as constraining the high-energy dispersion in the velocity of light (probing the structure of spacetime and Lorentz invariance). A wide field of view (~4 times that of current instruments) and excellent angular resolution (several times better than current instruments) will allow for an unprecedented survey of the Galactic plane, providing a deep unobscured survey of SNRs, X-ray binaries, pulsar-wind nebulae, molecular cloud complexes and other sources. The differential flux sensitivity of ~10-13 erg cm-2 sec-1 will rival the most sensitive X-ray instruments for these extended Galactic sources. The excellent capabilities of AGIS at energies below 100 GeV will provide sensitivity to AGN and GRBs out to cosmological redshifts, increasing the number of AGNs detected at high energies from about 20 to more than 100, permitting population studies that will provide valuable insights into both a unified model for AGN and a detailed measurement of the effects of intergalactic absorption from the diffuse extragalactic background light. A new instrument with fast-slewing wide-field telescopes could provide detections of a number of long-duration GRBs providing important physical constraints from this new spectral component. The new array will also have excellent background rejection and very large effective area

Six faint gamma-ray pulsars seen with the Fermi Large Area Telescope: Towards a sample blending into the background

DOE PAGES

Hou, X.; Smith, D. A.; Guillemot, L.; ...

2014-10-14

Context. Here, GeV gamma-ray pulsations from over 140 pulsars have been characterized using the Fermi Large Area Telescope, enabling improved understanding of the emission regions within the neutron star magnetospheres, and the contributions of pulsars to high energy electrons and diffuse gamma rays in the Milky Way. The first gamma-ray pulsars to be detected were the most intense and/or those with narrow pulses. Aims. As the Fermi mission progresses, progressively fainter objects can be studied. In addition to more distant pulsars (thus probing a larger volume of the Galaxy), or ones in high background regions (thus improving the sampling uniformitymore » across the Galactic plane), we detect pulsars with broader pulses or lower luminosity. Adding pulsars to our catalog with inclination angles that are rare in the observed sample, and/or with lower spindown power, will reduce the bias in the currently known gamma-ray pulsar population. Methods. We use rotation ephemerides derived from radio observations to phase-fold gamma rays recorded by the Fermi Large Area Telescope, to then determine the pulse profile properties. Spectral analysis provides the luminosities and, when the signal-to-noise ratio allows, the cutoff energies. We constrain the pulsar distances by different means in order to minimize the luminosity uncertainties. Results. We present six new gamma-ray pulsars with an eclectic mix of properties. Three are young, and three are recycled. They include the farthest, the lowest power, two of the highest duty-cycle pulsars seen, and only the fourth young gamma-ray pulsar with a radio interpulse. Finally, we discuss the biases existing in the current gamma-ray pulsar catalog, and steps to be taken to mitigate the bias.« less

A Platinum-Enriched gamma+gamma' Two-Phase Bond Coat on Ni-Base Superalloys

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhang, Ying; Pint, Bruce A; Haynes, James A

2005-01-01

Pt-enriched {gamma} + {gamma}{prime} two-phase coating was applied to directionally-solidified Ni-based superalloy Ren{acute e} 142 substrates with three different Hf levels (0.02, 0.76, and 1.37 wt.%). The coating was prepared by electroplating a thin layer of Pt on the superalloy followed by a diffusion treatment. The as-deposited coating exhibited a {gamma} + {gamma}{prime} two-phase microstructure with a major composition of Ni-16Al-18Pt-7Cr-9Co (in at.%) along with some incorporation of refractory elements from the substrates. Cyclic oxidation testing at 1100 C in air indicated improved oxidation resistance of the Ren{acute e} 142 alloys with the Pt-enriched {gamma} + {gamma}{prime} coatings. In addition,more » the oxidation resistance of both uncoated and coated alloys was proportional to the Hf content in the substrate. Compared with the single-phase {beta}-(Ni,Pt)Al coating, slightly higher mass gains and localized spallation were observed on the {gamma} + {gamma}{prime} two-phase coating, which might be due to the segregation of refractory elements and high sulfur levels in these superalloy substrates.« less

Fermi Gamma-Ray Imaging of a Radio Galaxy

DOE PAGES

Abdo, A. A.; Ackermann, M.; Ajello, M.; ...

2010-04-01

The Fermi Gamma-ray Space Telescope has detected the γ-ray glow emanating from the giant radio lobes of the radio galaxy Centaurus A. The resolved γ-ray image shows the lobes clearly separated from the central active source. In contrast to all other active galaxies detected so far in high-energy γ-rays, the lobe flux constitutes a considerable portion (greater than one-half) of the total source emission. The γ-ray emission from the lobes is interpreted as inverse Compton–scattered relic radiation from the cosmic microwave background, with additional contribution at higher energies from the infrared-to-optical extragalactic background light. In conclusion, these measurements provide γ-raymore » constraints on the magnetic field and particle energy content in radio galaxy lobes, as well as a promising method to probe the cosmic relic photon fields.« less

Gamma ray transients

NASA Technical Reports Server (NTRS)

Cline, Thomas L.

1987-01-01

The discovery of cosmic gamma ray bursts was made with systems designed at Los Alamos Laboratory for the detection of nuclear explosions beyond the atmosphere. HELIOS-2 was the first gamma ray burst instrument launched; its initial results in 1976, seemed to deepen the mystery around gamma ray transients. Interplanetary spacecraft data were reviewed in terms of explaining the behavior and source of the transients.

Expression of peroxisome proliferator-activated receptor gamma (PPAR-gamma) in canine nasal carcinomas.

PubMed

Paciello, O; Borzacchiello, G; Varricchio, E; Papparella, S

2007-10-01

Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a ligand-activated transcriptional factor belonging to the steroid receptor superfamily. PPAR-gamma is expressed in multiple normal and neoplastic tissues, such as the breast, colon, lung, ovary and placenta. In addition to adipogenic and anti-inflammatory effects, PPAR-gamma activation has been shown to be anti-proliferative by its differentiation-promoting effect, suggesting that activation of PPAR-gamma may be useful in slowing or arresting the proliferation of de-differentiated tumour cells. In this study, we investigated the expression of PPAR-gamma in normal and neoplastic canine nasal epithelium. Twenty-five samples composed of five normal nasal epithelia and 20 canine nasal carcinomas, were immunohistochemically stained for PPAR-gamma. The specificity of the antibody was verified by Western Blot analysis. Confocal laser scanning microscopical investigation was also performed. In normal epithelium, the staining pattern was cytoplasmic and polarized at the cellular free edge. In carcinomas, the neoplastic cells showed mainly strong cytoplasmatic PPAR-gamma expression; moreover, perinuclear immunoreactivity was also detected and few neoplastic cells exhibited a nuclear positivity. Our results demonstrate different patterns of PPAR-gamma expression in normal canine nasal epithelium when compared with canine nasal carcinoma. The importance of this transcription factor in the pathophysiology of several different tumours has stimulated much research in this field and has opened new opportunities for the treatment of the tumours.

Automatic enforcement and highway safety.

DOT National Transportation Integrated Search

2011-05-01

The objectives of this research are to: 1. Identify aspects of the automatic detection of red light running that the public finds offensive or problematical, and quantify the level of opposition on each aspect. 2. Identify aspects of the automatic de...

Accuracy of probing attachment levels using a new computerized cemento-enamel junction probe.

PubMed

Deepa, R; Prakash, Shobha

2012-01-01

The assessment of clinical attachment level (CAL) represents the gold standard for diagnosing and monitoring periodontal disease. The aim of the present study was to evaluate the performance of the newly introduced cemento-enamel junction (CEJ) probe in detecting CAL, using CEJ as a fixed reference point, and to compare the CEJ probe with the Florida stent probe (FSP) as well as with a standard manual probe, University of North Carolina-15 (UNC-15). Three examiners recorded the probing attachment level in 384 sites in case group (chronic periodontitis), and in 176 sites, in control group (healthy periodontal status), using the three probes. Subjects included both the sexes and ranged from 35 to 45 years. The experimental design was structured to balance the intra- and inter-examiner consistency at the same site during the two visits. CEJ probe showed higher intra-and inter-examiner consistency over both FSP and UNC-15 in both the case and control groups. Frequency distribution of differences of various magnitudes of repeated measurements ≤1 mm was in the higher range of 86.8% to 87.5% for CEJ probe. The FSP was more reproducible than UNC-15 in detecting relative attachment level (RAL). CEJ automated probe was found to have greatest potential for accuracy and consistency in detecting CAL than FSP and UNC-15. The automated probes appeared to be more reproducible than manual probes.

Revealing the supernova-gamma-ray burst connection with TeV neutrinos.

PubMed

Ando, Shin'ichiro; Beacom, John F

2005-08-05

Gamma-ray bursts (GRBs) are rare, powerful explosions displaying highly relativistic jets. It has been suggested that a significant fraction of the much more frequent core-collapse supernovae are accompanied by comparably energetic but mildly relativistic jets, which would indicate an underlying supernova-GRB connection. We calculate the neutrino spectra from the decays of pions and kaons produced in jets in supernovae, and show that the kaon contribution is dominant and provides a sharp break near 20 TeV, which is a sensitive probe of the conditions inside the jet. For a supernova at 10 Mpc, 30 events above 100 GeV are expected in a 10 s burst in the IceCube detector.

COSMOLOGY WITH THE Ep,i - Eiso CORRELATION OF GAMMA-RAY BURSTS

NASA Astrophysics Data System (ADS)

Amati, Lorenzo

2012-03-01

Gamma-Ray Bursts (GRBs) are the brightest sources in the universe, emit mostly in the hard X-ray energy band and have been detected at redshifts up to about 8.2. Thus, they are in principle very powerful probes for cosmology. I shortly review the researches aimed to use GRBs for the measurement of cosmological parameters, which are mainly based on the correlation between spectral peak photon energy and total radiated energy or luminosity. In particular, based on an enriched sample of 120 GRBs, I will provide an update of the analysis by Amati et al. (2008) aimed at extracting information on ΩM and, to a less extent, on ΩΛ, from the Ep,i - Eiso correlation.

Developing and testing a multi-probe resonance electrical impedance spectroscopy system for detecting breast abnormalities

NASA Astrophysics Data System (ADS)

Gur, David; Zheng, Bin; Dhurjaty, Sreeram; Wolfe, Gene; Fradin, Mary; Weil, Richard; Sumkin, Jules; Zuley, Margarita

2009-02-01

In our previous study, we reported on the development and preliminary testing of a prototype resonance electrical impedance spectroscopy (REIS) system with a pair of probes. Although our pilot study on 150 young women ranging from 30 to 50 years old indicated the feasibility of using REIS output sweep signals to classify between the women who had negative examinations and those who would ultimately be recommended for biopsy, the detection sensitivity was relatively low. To improve performance when using REIS technology, we recently developed a new multi-probe based REIS system. The system consists of a sensor module box that can be easily lifted along a vertical support device to fit women of different height. Two user selectable breast placement "cups" with different curvatures are included in the system. Seven probes are mounted on each of the cups on opposing sides of the sensor box. By rotating the sensor box, the technologist can select the detection sensor cup that better fits the breast size of the woman being examined. One probe is mounted in the cup center for direct contact with the nipple and the other six probes are uniformly distributed along an outside circle to enable contact with six points on the outer and inner breast skin surfaces. The outer probes are located at a distance of 60mm away from the center (nipple) probe. The system automatically monitors the quality of the contact between the breast surface and each of the seven probes and data acquisition can only be initiated when adequate contact is confirmed. The measurement time for each breast is approximately 15 seconds during which time the system records 121 REIS signal sweep outputs generated from 200 KHz to 800 KHz at 5 KHz increments for all preselected probe pairs. Currently we are measuring 6 pairs between the center probe and each of six probes located on the outer circle as well as two pairs between probe pairs on the outer circle. This new REIS system has been installed in our

Cloning, sequencing and expression of white rhinoceros (Ceratotherium simum) interferon-gamma (IFN-gamma) and the production of rhinoceros IFN-gamma specific antibodies.

PubMed

Morar, D; Tijhaar, E; Negrea, A; Hendriks, J; van Haarlem, D; Godfroid, J; Michel, A L; Rutten, V P M G

2007-01-15

Bovine tuberculosis (BTB) is endemic in African buffalo (Syncerus caffer) in the Kruger National Park (KNP). In addition to buffalo, Mycobacterium bovis has been found in at least 14 other mammalian species in South Africa, including kudu (Tragelaphus strepsiceros), Chacma baboon (Papio ursinus) and lion (Panthera leo). This has raised concern about the spillover into other potentially susceptible species like rhinoceros, thus jeopardising breeding and relocation projects aiming at the conservation of biodiversity. Hence, procedures to screen for and diagnose BTB in black rhinoceros (Diceros bicornis) and white rhinoceros (Ceratotherium simum) need to be in place. The Interferon-gamma (IFN-gamma) assay is used as a routine diagnostic tool to determine infection of cattle and recently African buffalo, with M. bovis and other mycobacteria. The aim of the present work was to develop reagents to set up a rhinoceros IFN-gamma (RhIFN-gamma) assay. The white rhinoceros IFN-gamma gene was cloned, sequenced and expressed as a mature protein. Amino acid (aa) sequence analysis revealed that RhIFN-gamma shares a homology of 90% with equine IFN-gamma. Monoclonal antibodies, as well as polyclonal chicken antibodies (Yolk Immunoglobulin-IgY) with specificity for recombinant RhIFN-gamma were produced. Using the monoclonals as capture antibodies and the polyclonal IgY for detection, it was shown that recombinant as well as native white rhinoceros IFN-gamma was recognised. This preliminary IFN-gamma enzyme-linked immunosorbent assay (ELISA), has the potential to be developed into a diagnostic assay for M. bovis infection in rhinoceros.

Measurements of the $$\\mathrm{ pp \\to W \\gamma\\gamma }$$ and $$\\mathrm{ pp \\to Z \\gamma\\gamma }$$ cross sections and limits on anomalous quartic gauge couplings at $$\\sqrt{s} =$$ 8 TeV

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sirunyan, A. M.; Tumasyan, A.; Adam, W.

Here, measurements are presented ofmore » $$ \\mathrm{ W \\gamma\\gamma } $$ and $$ \\mathrm{ Z \\gamma\\gamma } $$ production in proton-proton collisions. Fiducial cross sections are reported based on a data sample corresponding to an integrated luminosity of 19.4 fb$$^{-1}$$ collected with the CMS detector at a center-of-mass energy of 8 TeV. Signal is identified through the $$\\mathrm{ W } \\to \\ell\

Measurements of the $$\\mathrm{ pp \\to W \\gamma\\gamma }$$ and $$\\mathrm{ pp \\to Z \\gamma\\gamma }$$ cross sections and limits on anomalous quartic gauge couplings at $$\\sqrt{s} =$$ 8 TeV

DOE PAGES

Sirunyan, A. M.; Tumasyan, A.; Adam, W.; ...

2017-10-11

Here, measurements are presented ofmore » $$ \\mathrm{ W \\gamma\\gamma } $$ and $$ \\mathrm{ Z \\gamma\\gamma } $$ production in proton-proton collisions. Fiducial cross sections are reported based on a data sample corresponding to an integrated luminosity of 19.4 fb$$^{-1}$$ collected with the CMS detector at a center-of-mass energy of 8 TeV. Signal is identified through the $$\\mathrm{ W } \\to \\ell\

30 CFR 77.314 - Automatic temperature control instruments.

Code of Federal Regulations, 2011 CFR

2011-07-01

... UNDERGROUND COAL MINES Thermal Dryers § 77.314 Automatic temperature control instruments. (a) Automatic temperature control instruments for thermal dryer system shall be of the recording type. (b) Automatic... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Automatic temperature control instruments. 77...

30 CFR 77.314 - Automatic temperature control instruments.

Code of Federal Regulations, 2010 CFR

2010-07-01

... UNDERGROUND COAL MINES Thermal Dryers § 77.314 Automatic temperature control instruments. (a) Automatic temperature control instruments for thermal dryer system shall be of the recording type. (b) Automatic... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Automatic temperature control instruments. 77...

30 CFR 77.314 - Automatic temperature control instruments.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 30 Mineral Resources 1 2013-07-01 2013-07-01 false Automatic temperature control instruments. 77... UNDERGROUND COAL MINES Thermal Dryers § 77.314 Automatic temperature control instruments. (a) Automatic temperature control instruments for thermal dryer system shall be of the recording type. (b) Automatic...

30 CFR 77.314 - Automatic temperature control instruments.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 30 Mineral Resources 1 2012-07-01 2012-07-01 false Automatic temperature control instruments. 77... UNDERGROUND COAL MINES Thermal Dryers § 77.314 Automatic temperature control instruments. (a) Automatic temperature control instruments for thermal dryer system shall be of the recording type. (b) Automatic...

30 CFR 77.314 - Automatic temperature control instruments.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 30 Mineral Resources 1 2014-07-01 2014-07-01 false Automatic temperature control instruments. 77... UNDERGROUND COAL MINES Thermal Dryers § 77.314 Automatic temperature control instruments. (a) Automatic temperature control instruments for thermal dryer system shall be of the recording type. (b) Automatic...

Feasibility of utilizing Cherenkov Telescope Array gamma-ray telescopes as free-space optical communication ground stations.

PubMed

Carrasco-Casado, Alberto; Vilera, Mariafernanda; Vergaz, Ricardo; Cabrero, Juan Francisco

2013-04-10

The signals that will be received on Earth from deep-space probes in future implementations of free-space optical communication will be extremely weak, and new ground stations will have to be developed in order to support these links. This paper addresses the feasibility of using the technology developed in the gamma-ray telescopes that will make up the Cherenkov Telescope Array (CTA) observatory in the implementation of a new kind of ground station. Among the main advantages that these telescopes provide are the much larger apertures needed to overcome the power limitation that ground-based gamma-ray astronomy and optical communication both have. Also, the large number of big telescopes that will be built for CTA will make it possible to reduce costs by economy-scale production, enabling optical communications in the large telescopes that will be needed for future deep-space links.

Thai Automatic Speech Recognition

DTIC Science & Technology

2005-01-01

used in an external DARPA evaluation involving medical scenarios between an American Doctor and a naïve monolingual Thai patient. 2. Thai Language... dictionary generation more challenging, and (3) the lack of word segmentation, which calls for automatic segmentation approaches to make n-gram language...requires a dictionary and provides various segmentation algorithms to automatically select suitable segmentations. Here we used a maximal matching

Automatic programming of simulation models

NASA Technical Reports Server (NTRS)

Schroer, Bernard J.; Tseng, Fan T.; Zhang, Shou X.; Dwan, Wen S.

1988-01-01

The objective of automatic programming is to improve the overall environment for describing the program. This improved environment is realized by a reduction in the amount of detail that the programmer needs to know and is exposed to. Furthermore, this improved environment is achieved by a specification language that is more natural to the user's problem domain and to the user's way of thinking and looking at the problem. The goal of this research is to apply the concepts of automatic programming (AP) to modeling discrete event simulation system. Specific emphasis is on the design and development of simulation tools to assist the modeler define or construct a model of the system and to then automatically write the corresponding simulation code in the target simulation language, GPSS/PC. A related goal is to evaluate the feasibility of various languages for constructing automatic programming simulation tools.

Clothes Dryer Automatic Termination Evaluation

DOE Office of Scientific and Technical Information (OSTI.GOV)

TeGrotenhuis, Ward E.

Volume 2: Improved Sensor and Control Designs Many residential clothes dryers on the market today provide automatic cycles that are intended to stop when the clothes are dry, as determined by the final remaining moisture content (RMC). However, testing of automatic termination cycles has shown that many dryers are susceptible to over-drying of loads, leading to excess energy consumption. In particular, tests performed using the DOE Test Procedure in Appendix D2 of 10 CFR 430 subpart B have shown that as much as 62% of the energy used in a cycle may be from over-drying. Volume 1 of this reportmore » shows an average of 20% excess energy from over-drying when running automatic cycles with various load compositions and dryer settings. Consequently, improving automatic termination sensors and algorithms has the potential for substantial energy savings in the U.S.« less

Application of a unique server-based oligonucleotide probe selection tool toward a novel biosensor for the detection of Streptococcus pyogenes.

PubMed

Nugen, Sam R; Leonard, Barbara; Baeumner, Antje J

2007-05-15

We developed a software program for the rapid selection of detection probes to be used in nucleic acid-based assays. In comparison to commercially available software packages, our program allows the addition of oligotags as required by nucleic acid sequence-based amplification (NASBA) as well as automatic BLAST searches for all probe/primer pairs. We then demonstrated the usefulness of the program by designing a novel lateral flow biosensor for Streptococcus pyogenes that does not rely on amplification methods such as the polymerase chain reaction (PCR) or NASBA to obtain low limits of detection, but instead uses multiple reporter and capture probes per target sequence and an instantaneous amplification via dye-encapsulating liposomes. These assays will decrease the detection time to just a 20 min hybridization reaction and avoid costly enzymatic gene amplification reactions. The lateral flow assay was developed quantifying the 16S rRNA from S. pyogenes by designing reporter and capture probes that specifically hybridize with the RNA and form a sandwich. DNA reporter probes were tagged with dye-encapsulating liposomes, biotinylated DNA oligonucleotides were used as capture probes. From the initial number of capture and reporter probes chosen, a combination of two capture and three reporter probes were found to provide optimal signal generation and significant enhancement over single capture/reporter probe combinations. The selectivity of the biosensor was proven by analyzing organisms closely related to S. pyogenes, such as other Streptococcus and Enterococcus species. All probes had been selected by the software program within minutes and no iterative optimization and re-design of the oligonucleotides was required which enabled a very rapid biosensor prototyping. While the sensitivity obtained with the biosensor was only 135 ng, future experiments will decrease this significantly by the addition of more reporter and capture probes for either the same rRNA or a

Pump-probe Kelvin-probe force microscopy: Principle of operation and resolution limits

DOE Office of Scientific and Technical Information (OSTI.GOV)

Murawski, J.; Graupner, T.; Milde, P., E-mail: peter.milde@tu-dresden.de

Knowledge on surface potential dynamics is crucial for understanding the performance of modern-type nanoscale devices. We describe an electrical pump-probe approach in Kelvin-probe force microscopy that enables a quantitative measurement of dynamic surface potentials at nanosecond-time and nanometer-length scales. Also, we investigate the performance of pump-probe Kelvin-probe force microscopy with respect to the relevant experimental parameters. We exemplify a measurement on an organic field effect transistor that verifies the undisturbed functionality of our pump-probe approach in terms of simultaneous and quantitative mapping of topographic and electronic information at a high lateral and temporal resolution.

Mutant quantity and quality in mammalian cells (A{sub L}) exposed to cesium-137 gamma radiation: Effect of caffeine

DOE Office of Scientific and Technical Information (OSTI.GOV)

McGuinness, S.M.; Shibuya, M.L.; Ueno, A.M.

1995-06-01

We examined the effect of caffeine (1,3,7-trimethylxanthine) on the quantity and quality of mutations in cultured mammalian A{sub L} human-hamster hybrid cells exposed to {sup 137}Cs {gamma} radiation. At a dose (1.5 mg/ml for 16 h) that reduced the plating efficiency (PE) by 20%, caffeine was not itself a significant mutagen, but it increased by approximately twofold the slope of the dose-response curve for induction of S1{sup {minus}} mutants by {sup 137}Cs {gamma} radiation. Molecular analysis of 235 S1{sup {minus}} mutants using a series of DNA probes mapped to the human chromosome 11 in the A{sub L} hybrid cells revealedmore » that 73 to 85% of the mutations in unexposed cells and in cells treated with caffeine alone, {sup 137}Cs {gamma} rays alone or {sup 137}Cs {gamma} rays plus caffeine were large deletions involving millions of base pairs of DNA. Most of these deletions were contiguous with the region of the MIC1 gene at 11p13 that encodes the S1 cell surface antigen. In other mutants that had suffered multiple marker loss, the deletions were intermittent along chromosome 11. These {open_quotes}complex{close_quotes} mutations were rare for {sup 137}Cs {gamma} irradiation (1/63 = 1.5%) but relatively prevalent (23-50%) for other exposure conditions. Thus caffeine appears to alter both the quantity and quality of mutations induced by {sup 137}Cs {gamma} irradiation. 62 refs., 3 figs., 3 tabs.« less

Microwave probe stations with three-dimensional control of the magnetic field to study high-frequency dynamics in nanoscale devices

NASA Astrophysics Data System (ADS)

Banuazizi, Seyed Amir Hossein; Åkerman, Johan

2018-06-01

We present two microwave probe stations with motorized rotary stages for adjusting the magnitude and angle of the applied magnetic field. In the first system, the magnetic field is provided by an electromagnet and can be adjusted from 0 to ˜1.4 T while its polar angle (θ) can be varied from 0° to 360°. In the second system, the magnetic field is provided by a Halbach array permanent magnet, which can be rotated and translated to cover the full range of polar (θ) and azimuthal (φ) angles with a tunable field magnitude up to ˜1 T. Both systems are equipped with microwave probes, bias-Ts, amplifiers, and spectrum analyzers to allow for microwave characterization up to 40 GHz, as well as software to automatically perform continuous large sets of electrical and microwave measurements.

Basics of Gamma Ray Detection

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stinnett, Jacob; Venkataraman, Ram

The objective of this training is to explain the origin of x-rays and gamma rays, gamma ray interactions with matter, detectors and electronics used in gamma ray-spectrometry, and features of a gamma-ray spectrum for nuclear material that is safeguarded.

The Advanced Energetic Pair Telescope (AdEPT}: A Future Medium-Energy Gamma-Ray Balloon (and Explorer?) Mission

NASA Technical Reports Server (NTRS)

Hunter, Stanley D.

2011-01-01

Gamma-ray astrophysics probes the highest energy, exotic phenomena in astrophysics. In the medium-energy regime, 0.1-200 MeV, many astrophysical objects exhibit unique and transitory behavior such as the transition from electron dominated to hadron dominated processes, spectral breaks, bursts, and flares. Medium-energy gamma-ray imaging however, continues to be a major challenge particularly because of high background, low effective area, and low source intensities. The sensitivity and angular resolution required to address these challenges requires a leap in technology. The Advance Energetic Pair Telescope (AdEPT) being developed at GSFC is designed to image gamma rays above 5 MeV via pair production with angular resolution of 1-10 deg. In addition AdEPT will, for the first time, provide high polarization sensitivity in this energy range. This performance is achieved by reducing the effective area in favor of enhanced angular resolution through the use of a low-density gaseous conversion medium. AdEPT is based on the Three-Dimensional Track Imager (3-DTI) technology that combines a large volume Negative Ion Time Projection Chamber (NITPC) with 2-D Micro-Well Detector (MWD) readout. I will review the major science topics addressable with medium-energy gamma-rays and discuss the current status of the AdEPT technology, a proposed balloon instrument, and the design of a future satellite mission.

SEARCH FOR GAMMA-RAY EMISSION FROM X-RAY-SELECTED SEYFERT GALAXIES WITH FERMI-LAT

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ackermann, M.; Ajello, M.; Allafort, A.

We report on a systematic investigation of the {gamma}-ray properties of 120 hard X-ray-selected Seyfert galaxies classified as 'radio-quiet' objects, utilizing the three-year accumulation of Fermi Large Area Telescope (LAT) data. Our sample of Seyfert galaxies is selected using the Swift Burst Alert Telescope 58 month catalog, restricting the analysis to the bright sources with average hard X-ray fluxes F{sub 14-195keV} {>=} 2.5 Multiplication-Sign 10{sup -11} erg cm{sup -2} s{sup -1} at high Galactic latitudes (|b| > 10 Degree-Sign ). In order to remove 'radio-loud' objects from the sample, we use the 'hard X-ray radio loudness parameter', R{sub rX}, definedmore » as the ratio of the total 1.4 GHz radio to 14-195 keV hard X-ray energy fluxes. Among 120 X-ray bright Seyfert galaxies with R{sub rX} <10{sup -4}, we did not find a statistically significant {gamma}-ray excess (TS > 25) positionally coincident with any target Seyferts, with possible exceptions of ESO 323-G077 and NGC 6814. The mean value of the 95% confidence level {gamma}-ray upper limit for the integrated photon flux above 100 MeV from the analyzed Seyferts is {approx_equal} 4 Multiplication-Sign 10{sup -9} photons cm{sup -2} s{sup -1} , and the upper limits derived for several objects reach {approx_equal} 1 Multiplication-Sign 10{sup -9} photons cm{sup -2} s{sup -1} . Our results indicate that no prominent {gamma}-ray emission component related to active galactic nucleus activity is present in the spectra of Seyferts around GeV energies. The Fermi-LAT upper limits derived for our sample probe the ratio of {gamma}-ray to X-ray luminosities L{sub {gamma}}/L{sub X} < 0.1, and even <0.01 in some cases. The obtained results impose novel constraints on the models for high-energy radiation of 'radio-quiet' Seyfert galaxies.« less

Theta and gamma coordination of hippocampal networks during waking and rapid eye movement sleep.

PubMed

Montgomery, Sean M; Sirota, Anton; Buzsáki, György

2008-06-25

Rapid eye movement (REM) sleep has been considered a paradoxical state because, despite the high behavioral threshold to arousing perturbations, gross physiological patterns in the forebrain resemble those of waking states. To understand how intrahippocampal networks interact during REM sleep, we used 96 site silicon probes to record from different hippocampal subregions and compared the patterns of activity during waking exploration and REM sleep. Dentate/CA3 theta and gamma synchrony was significantly higher during REM sleep compared with active waking. In contrast, gamma power in CA1 and CA3-CA1 gamma coherence showed significant decreases in REM sleep. Changes in unit firing rhythmicity and unit-field coherence specified the local generation of these patterns. Although these patterns of hippocampal network coordination characterized the more common tonic periods of REM sleep (approximately 95% of total REM), we also detected large phasic bursts of local field potential power in the dentate molecular layer that were accompanied by transient increases in the firing of dentate and CA1 neurons. In contrast to tonic REM periods, phasic REM epochs were characterized by higher theta and gamma synchrony among the dentate, CA3, and CA1 regions. These data suggest enhanced dentate processing, but limited CA3-CA1 coordination during tonic REM sleep. In contrast, phasic bursts of activity during REM sleep may provide windows of opportunity to synchronize the hippocampal trisynaptic loop and increase output to cortical targets. We hypothesize that tonic REM sleep may support off-line mnemonic processing, whereas phasic bursts of activity during REM may promote memory consolidation.

10 CFR 429.45 - Automatic commercial ice makers.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 10 Energy 3 2012-01-01 2012-01-01 false Automatic commercial ice makers. 429.45 Section 429.45... PRODUCTS AND COMMERCIAL AND INDUSTRIAL EQUIPMENT Certification § 429.45 Automatic commercial ice makers. (a... automatic commercial ice makers; and (2) For each basic model of automatic commercial ice maker selected for...

10 CFR 429.45 - Automatic commercial ice makers.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 10 Energy 3 2014-01-01 2014-01-01 false Automatic commercial ice makers. 429.45 Section 429.45... PRODUCTS AND COMMERCIAL AND INDUSTRIAL EQUIPMENT Certification § 429.45 Automatic commercial ice makers. (a... automatic commercial ice makers; and (2) For each basic model of automatic commercial ice maker selected for...

10 CFR 429.45 - Automatic commercial ice makers.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 10 Energy 3 2013-01-01 2013-01-01 false Automatic commercial ice makers. 429.45 Section 429.45... PRODUCTS AND COMMERCIAL AND INDUSTRIAL EQUIPMENT Certification § 429.45 Automatic commercial ice makers. (a... automatic commercial ice makers; and (2) For each basic model of automatic commercial ice maker selected for...

Computer systems for automatic earthquake detection

USGS Publications Warehouse

Stewart, S.W.

1974-01-01

U.S Geological Survey seismologists in Menlo park, California, are utilizing the speed, reliability, and efficiency of minicomputers to monitor seismograph stations and to automatically detect earthquakes. An earthquake detection computer system, believed to be the only one of its kind in operation, automatically reports about 90 percent of all local earthquakes recorded by a network of over 100 central California seismograph stations. The system also monitors the stations for signs of malfunction or abnormal operation. Before the automatic system was put in operation, all of the earthquakes recorded had to be detected by manually searching the records, a time-consuming process. With the automatic detection system, the stations are efficiently monitored continuously. 

Energy input and response from prompt and early optical afterglow emission in gamma-ray bursts.

PubMed

Vestrand, W T; Wren, J A; Wozniak, P R; Aptekar, R; Golentskii, S; Pal'shin, V; Sakamoto, T; White, R R; Evans, S; Casperson, D; Fenimore, E

2006-07-13

The taxonomy of optical emission detected during the critical first few minutes after the onset of a gamma-ray burst (GRB) defines two broad classes: prompt optical emission correlated with prompt gamma-ray emission, and early optical afterglow emission uncorrelated with the gamma-ray emission. The standard theoretical interpretation attributes prompt emission to internal shocks in the ultra-relativistic outflow generated by the internal engine; early afterglow emission is attributed to shocks generated by interaction with the surrounding medium. Here we report on observations of a bright GRB that, for the first time, clearly show the temporal relationship and relative strength of the two optical components. The observations indicate that early afterglow emission can be understood as reverberation of the energy input measured by prompt emission. Measurements of the early afterglow reverberations therefore probe the structure of the environment around the burst, whereas the subsequent response to late-time impulsive energy releases reveals how earlier flaring episodes have altered the jet and environment parameters. Many GRBs are generated by the death of massive stars that were born and died before the Universe was ten per cent of its current age, so GRB afterglow reverberations provide clues about the environments around some of the first stars.

Sentinel node biopsy and concomitant probe-guided tumor excision of nonpalpable breast cancer.

PubMed

van Rijk, Maartje C; Tanis, Pieter J; Nieweg, Omgo E; Loo, Claudette E; Olmos, Renato A Valdés; Oldenburg, Hester S A; Rutgers, Emiel J Th; Hoefnagel, Cornelis A; Kroon, Bin B R

2007-02-01

Preliminary data have shown encouraging results of a single intratumoral radiopharmaceutical injection that enables both sentinel node biopsy and probe-guided excision of the primary tumor in patients with nonpalpable breast cancer. The aim of the study was to evaluate this approach in a large group of patients. Lymphoscintigraphy was performed in 368 patients with nonpalpable breast cancer after intratumoral injection of (99m)Tc-nanocolloid (.2 mL, 123 MBq, 3.3 mCi) guided by ultrasound or stereotaxis. The sentinel node was pursued with the aid of vital blue dye (1.0 mL, intratumoral) and a gamma ray detection probe. In case of breast-conserving surgery, the probe was used to guide the excision. At least one sentinel node could be identified intraoperatively in 357 patients (97%), of whom 69 had involved nodes (19%). Age over 60 years was associated with less frequent nonaxillary lymphatic drainage and absence of internal mammary chain dissemination. Tumor-free margins were obtained in 262 (89%) of the 293 patients who underwent segmental excision. Re-excision of the primary tumor bed was performed in six patients (2%). During a median follow-up of 22 months, one breast recurrence and one axillary recurrence were observed. Lymphatic mapping and probe-guided tumor excision of nonpalpable breast cancer by intralesional administration of a single dose of (99m)Tc-nanocolloid and blue dye resulted in 97% identification of the sentinel node and in tumor-free margins in 89% of the patients who underwent breast-conserving surgery. Longer follow-up is needed to substantiate the accuracy and safety of this technique.

Circumferential pressure probe

NASA Technical Reports Server (NTRS)

Holmes, Harlan K. (Inventor); Moore, Thomas C. (Inventor); Fantl, Andrew J. (Inventor)

1989-01-01

A probe for measuring circumferential pressure inside a body cavity is disclosed. In the preferred embodiment, a urodynamic pressure measurement probe for evaluating human urinary sphincter function is disclosed. Along the length of the probe are disposed a multiplicity of deformable wall sensors which typically comprise support tube sections with flexible side wall areas. These are arranged along the length of the probe in two areas, one just proximal to the tip for the sensing of fluid pressure inside the bladder, and five in the sensing section which is positioned within the urethra at the point at which the urinary sphincter constricts to control the flow of urine. The remainder of the length of the probe comprises multiple rigid support tube sections interspersed with flexible support tube sections in the form of bellows to provide flexibility.

Automatic ultrasound image enhancement for 2D semi-automatic breast-lesion segmentation

NASA Astrophysics Data System (ADS)

Lu, Kongkuo; Hall, Christopher S.

2014-03-01

Breast cancer is the fastest growing cancer, accounting for 29%, of new cases in 2012, and second leading cause of cancer death among women in the United States and worldwide. Ultrasound (US) has been used as an indispensable tool for breast cancer detection/diagnosis and treatment. In computer-aided assistance, lesion segmentation is a preliminary but vital step, but the task is quite challenging in US images, due to imaging artifacts that complicate detection and measurement of the suspect lesions. The lesions usually present with poor boundary features and vary significantly in size, shape, and intensity distribution between cases. Automatic methods are highly application dependent while manual tracing methods are extremely time consuming and have a great deal of intra- and inter- observer variability. Semi-automatic approaches are designed to counterbalance the advantage and drawbacks of the automatic and manual methods. However, considerable user interaction might be necessary to ensure reasonable segmentation for a wide range of lesions. This work proposes an automatic enhancement approach to improve the boundary searching ability of the live wire method to reduce necessary user interaction while keeping the segmentation performance. Based on the results of segmentation of 50 2D breast lesions in US images, less user interaction is required to achieve desired accuracy, i.e. < 80%, when auto-enhancement is applied for live-wire segmentation.

AUTOMATIC COUNTING APPARATUS

DOEpatents

Howell, W.D.

1957-08-20

An apparatus for automatically recording the results of counting operations on trains of electrical pulses is described. The disadvantages of prior devices utilizing the two common methods of obtaining the count rate are overcome by this apparatus; in the case of time controlled operation, the disclosed system automatically records amy information stored by the scaler but not transferred to the printer at the end of the predetermined time controlled operations and, in the case of count controlled operation, provision is made to prevent a weak sample from occupying the apparatus for an excessively long period of time.

Galactic plane gamma-radiation

NASA Technical Reports Server (NTRS)

Hartman, R. C.; Kniffen, D. A.; Thompson, D. J.; Fichtel, C. E.; Ogelman, H. B.; Tumer, T.; Ozel, M. E.

1979-01-01

Analysis of the SAS 2 data together with the COS B results shows that the distribution of galactic gamma-radiation has several similarities to that of other large-scale tracers of galactic structure. The radiation is primarily confined to a thin disc which exhibits offsets from b = 0 degrees similar to warping at radio frequencies. The principal distinction of the gamma-radiation is a stronger contrast in intensity between the region from 310 to 45 degrees in longitude and the regions away from the center that can be attributed to a variation in cosmic-ray density as a function of position in Galaxy. The diffuse galactic gamma-ray energy spectrum shows no significant variation in direction, and the spectrum seen along the plane is the same as that for the galactic component of the gamma-radiation at high altitudes. The uniformity of the galactic gamma-ray spectrum, the smooth decrease in intensity as a function of altitude, and the absence of any galactic gamma-ray sources at high altitudes indicate a diffuse origin for bulk of the galactic gamma-radiation rather than a collection of localized sources.

Gamma-ray burster recurrence timescales

NASA Technical Reports Server (NTRS)

Schaefer, B. E.; Cline, T. L.

1984-01-01

Three optical transients have been found which are associated with gamma-ray bursters (GRBs). The deduced recurrence timescale for these optical transients (tau sub opt) will depend on the minimum brightness for which a flash would be detected. A detailed analysis using all available data of tau sub opt as a function of E(gamma)/E(opt) is given. For flashes similar to those found in the Harvard archives, the best estimate of tau sub opt is 0.74 years, with a 99% confidence interval from 0.23 years to 4.7 years. It is currently unclear whether the optical transients from GRBs also give rise to gamma-ray events. One way to test this association is to measure the recurrence timescale of gamma-ray events tau sub gamma. A total of 210 gamma-ray error boxes were examined and it was found that the number of observed overlaps is not significantly different from the number expected from chance coincidence. This observation can be used to place limits on tau sub gamma for an assumed luminosity function. It was found that tau sub gamma is approx. 10 yr if bursts are monoenergetic. However, if GRBs have a power law luminosity function with a wide dynamic range, then the limit is tau sub gamma 0.5 yr. Hence, the gamma-ray data do not require tau sub gamma and tau sub opt to be different.

Gamma watermarking

DOEpatents

Ishikawa, Muriel Y.; Wood, Lowell L.; Lougheed, Ronald W.; Moody, Kenton J.; Wang, Tzu-Fang

2004-05-25

A covert, gamma-ray "signature" is used as a "watermark" for property identification. This new watermarking technology is based on a unique steganographic or "hidden writing" digital signature, implemented in tiny quantities of gamma-ray-emitting radioisotopic material combinations, generally covertly emplaced on or within an object. This digital signature may be readily recovered at distant future times, by placing a sensitive, high energy-resolution gamma-ray detecting instrument reasonably precisely over the location of the watermark, which location may be known only to the object's owner; however, the signature is concealed from all ordinary detection means because its exceedingly low level of activity is obscured by the natural radiation background (including the gamma radiation naturally emanating from the object itself, from cosmic radiation and material surroundings, from human bodies, etc.). The "watermark" is used in object-tagging for establishing object identity, history or ownership. It thus may serve as an aid to law enforcement officials in identifying stolen property and prosecuting theft thereof. Highly effective, potentially very low cost identification-on demand of items of most all types is thus made possible.

Flow measurements in sewers based on image analysis: automatic flow velocity algorithm.

PubMed

Jeanbourquin, D; Sage, D; Nguyen, L; Schaeli, B; Kayal, S; Barry, D A; Rossi, L

2011-01-01

Discharges of combined sewer overflows (CSOs) and stormwater are recognized as an important source of environmental contamination. However, the harsh sewer environment and particular hydraulic conditions during rain events reduce the reliability of traditional flow measurement probes. An in situ system for sewer water flow monitoring based on video images was evaluated. Algorithms to determine water velocities were developed based on image-processing techniques. The image-based water velocity algorithm identifies surface features and measures their positions with respect to real world coordinates. A web-based user interface and a three-tier system architecture enable remote configuration of the cameras and the image-processing algorithms in order to calculate automatically flow velocity on-line. Results of investigations conducted in a CSO are presented. The system was found to measure reliably water velocities, thereby providing the means to understand particular hydraulic behaviors.

The Gamma-ray Sky with Fermi

NASA Technical Reports Server (NTRS)

Thompson, David

2012-01-01

Gamma rays reveal extreme, nonthermal conditions in the Universe. The Fermi Gamma-ray Space Telescope has been exploring the gamma-ray sky for more than four years, enabling a search for powerful transients like gamma-ray bursts, novae, solar flares, and flaring active galactic nuclei, as well as long-term studies including pulsars, binary systems, supernova remnants, and searches for predicted sources of gamma rays such as dark matter annihilation. Some results include a stringent limit on Lorentz invariance derived from a gamma-ray burst, unexpected gamma-ray variability from the Crab Nebula, a huge gamma-ray structure associated with the center of our galaxy, surprising behavior from some gamma-ray binary systems, and a possible constraint on some WIMP models for dark matter.

Semi-automatic knee cartilage segmentation

NASA Astrophysics Data System (ADS)

Dam, Erik B.; Folkesson, Jenny; Pettersen, Paola C.; Christiansen, Claus

2006-03-01

Osteo-Arthritis (OA) is a very common age-related cause of pain and reduced range of motion. A central effect of OA is wear-down of the articular cartilage that otherwise ensures smooth joint motion. Quantification of the cartilage breakdown is central in monitoring disease progression and therefore cartilage segmentation is required. Recent advances allow automatic cartilage segmentation with high accuracy in most cases. However, the automatic methods still fail in some problematic cases. For clinical studies, even if a few failing cases will be averaged out in the overall results, this reduces the mean accuracy and precision and thereby necessitates larger/longer studies. Since the severe OA cases are often most problematic for the automatic methods, there is even a risk that the quantification will introduce a bias in the results. Therefore, interactive inspection and correction of these problematic cases is desirable. For diagnosis on individuals, this is even more crucial since the diagnosis will otherwise simply fail. We introduce and evaluate a semi-automatic cartilage segmentation method combining an automatic pre-segmentation with an interactive step that allows inspection and correction. The automatic step consists of voxel classification based on supervised learning. The interactive step combines a watershed transformation of the original scan with the posterior probability map from the classification step at sub-voxel precision. We evaluate the method for the task of segmenting the tibial cartilage sheet from low-field magnetic resonance imaging (MRI) of knees. The evaluation shows that the combined method allows accurate and highly reproducible correction of the segmentation of even the worst cases in approximately ten minutes of interaction.

Gamma Ray Astronomy

NASA Technical Reports Server (NTRS)

Wu, S. T.

2000-01-01

The project has progressed successfully during this period of performance. The highlights of the Gamma Ray Astronomy teams efforts are: (1) Support daily BATSE data operations, including receipt, archival and dissemination of data, quick-look science analysis, rapid gamma-ray burst and transient monitoring and response efforts, instrument state-of-health monitoring, and instrument commanding and configuration; (2) On-going scientific analysis, including production and maintenance of gamma-ray burst, pulsed source and occultation source catalogs, gamma-ray burst spectroscopy, studies of the properties of pulsars and black holes, and long-term monitoring of hard x-ray sources; (3) Maintenance and continuous improvement of BATSE instrument response and calibration data bases; (4) Investigation of the use of solid state detectors for eventual application and instrument to perform all sky monitoring of X-Ray and Gamma sources with high sensitivity; and (5) Support of BATSE outreach activities, including seminars, colloquia and World Wide Web pages. The highlights of this efforts can be summarized in the publications and presentation list.

Modular Rake of Pitot Probes

NASA Technical Reports Server (NTRS)

Dunlap, Timothy A.; Henry, Michael W.; Homyk, Raymond P.

2004-01-01

The figure presents selected views of a modular rake of 17 pitot probes for measuring both transient and steady-state pressures in a supersonic wind tunnel. In addition to pitot tubes visible in the figure, the probe modules contain (1) high-frequency dynamic-pressure transducers connected through wires to remote monitoring circuitry and (2) flow passages that lead to tubes that, in turn, lead to remote steady-state pressure transducers. Prior pitot-probe rakes were fabricated as unitary structures, into which the individual pitot probes were brazed. Repair or replacement of individual probes was difficult, costly, and time-consuming because (1) it was necessary to remove entire rakes in order to unbraze individual malfunctioning probes and (2) the heat of unbrazing a failed probe and of brazing a new probe in place could damage adjacent probes. In contrast, the modules in the present probe are designed to be relatively quickly and easily replaceable with no heating and, in many cases, without need for removal of the entire rake from the wind tunnel. To remove a malfunctioning probe, one first removes a screw-mounted V-cross-section cover that holds the probe and adjacent probes in place. Then one removes a screw-mounted cover plate to gain access to the steady-state pressure tubes and dynamicpressure wires. Next, one disconnects the tube and wires of the affected probe. Finally, one installs a new probe in the reverse of the aforementioned sequence. The wire connections can be made by soldering, but to facilitate removal and installation, they can be made via miniature plugs and sockets. The connections between the probe flow passages and the tubes leading to the remote pressure sensors can be made by use of any of a variety of readily available flexible tubes that can be easily pulled off and slid back on for removal and installation, respectively.

Gamma ray detector shield

DOEpatents

Ohlinger, R.D.; Humphrey, H.W.

1985-08-26

A gamma ray detector shield comprised of a rigid, lead, cylindrical-shaped vessel having upper and lower portions with an pneumatically driven, sliding top assembly. Disposed inside the lead shield is a gamma ray scintillation crystal detector. Access to the gamma detector is through the sliding top assembly.

Changes in automatic threat processing precede and predict clinical changes with exposure-based cognitive-behavior therapy for panic disorder.

PubMed

Reinecke, Andrea; Waldenmaier, Lara; Cooper, Myra J; Harmer, Catherine J

2013-06-01

Cognitive behavioral therapy (CBT) is an effective treatment for emotional disorders such as anxiety or depression, but the mechanisms underlying successful intervention are far from understood. Although it has been a long-held view that psychopharmacological approaches work by directly targeting automatic emotional information processing in the brain, it is usually postulated that psychological treatments affect these processes only over time, through changes in more conscious thought cycles. This study explored the role of early changes in emotional information processing in CBT action. Twenty-eight untreated patients with panic disorder were randomized to a single session of exposure-based CBT or waiting group. Emotional information processing was measured on the day after intervention with an attentional visual probe task, and clinical symptoms were assessed on the day after intervention and at 4-week follow-up. Vigilance for threat information was decreased in the treated group, compared with the waiting group, the day after intervention, before reductions in clinical symptoms. The magnitude of this early effect on threat vigilance predicted therapeutic response after 4 weeks. Cognitive behavioral therapy rapidly affects automatic processing, and these early effects are predictive of later therapeutic change. Such results suggest very fast action on automatic processes mediating threat sensitivity, and they provide an early marker of treatment response. Furthermore, these findings challenge the notion that psychological treatments work directly on conscious thought processes before automatic information processing and imply a greater similarity between early effects of pharmacological and psychological treatments for anxiety than previously thought. Copyright © 2013 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.

Automatic query formulations in information retrieval.

PubMed

Salton, G; Buckley, C; Fox, E A

1983-07-01

Modern information retrieval systems are designed to supply relevant information in response to requests received from the user population. In most retrieval environments the search requests consist of keywords, or index terms, interrelated by appropriate Boolean operators. Since it is difficult for untrained users to generate effective Boolean search requests, trained search intermediaries are normally used to translate original statements of user need into useful Boolean search formulations. Methods are introduced in this study which reduce the role of the search intermediaries by making it possible to generate Boolean search formulations completely automatically from natural language statements provided by the system patrons. Frequency considerations are used automatically to generate appropriate term combinations as well as Boolean connectives relating the terms. Methods are covered to produce automatic query formulations both in a standard Boolean logic system, as well as in an extended Boolean system in which the strict interpretation of the connectives is relaxed. Experimental results are supplied to evaluate the effectiveness of the automatic query formulation process, and methods are described for applying the automatic query formulation process in practice.

Adding Automatic Evaluation to Interactive Virtual Labs

ERIC Educational Resources Information Center

Farias, Gonzalo; Muñoz de la Peña, David; Gómez-Estern, Fabio; De la Torre, Luis; Sánchez, Carlos; Dormido, Sebastián

2016-01-01

Automatic evaluation is a challenging field that has been addressed by the academic community in order to reduce the assessment workload. In this work we present a new element for the authoring tool Easy Java Simulations (EJS). This element, which is named automatic evaluation element (AEE), provides automatic evaluation to virtual and remote…

An in situ probe for on-line monitoring of cell density and viability on the basis of dark field microscopy in conjunction with image processing and supervised machine learning.

PubMed

Wei, Ning; You, Jia; Friehs, Karl; Flaschel, Erwin; Nattkemper, Tim Wilhelm

2007-08-15

Fermentation industries would benefit from on-line monitoring of important parameters describing cell growth such as cell density and viability during fermentation processes. For this purpose, an in situ probe has been developed, which utilizes a dark field illumination unit to obtain high contrast images with an integrated CCD camera. To test the probe, brewer's yeast Saccharomyces cerevisiae is chosen as the target microorganism. Images of the yeast cells in the bioreactors are captured, processed, and analyzed automatically by means of mechatronics, image processing, and machine learning. Two support vector machine based classifiers are used for separating cells from background, and for distinguishing live from dead cells afterwards. The evaluation of the in situ experiments showed strong correlation between results obtained by the probe and those by widely accepted standard methods. Thus, the in situ probe has been proved to be a feasible device for on-line monitoring of both cell density and viability with high accuracy and stability. (c) 2007 Wiley Periodicals, Inc.

Wetting characteristics and blood clotting on surfaces of copoly(gamma-Benzyl-L-glutamate, gamma-hydroxyethyl-L-glutamine).

PubMed

Yano, E; Komai, T; Kawasaki, T; Kaifu, K; Atsuta, T; Kubo, Y; Fujiwara, Y

1985-09-01

The film surface of poly(gamma-benzyl-L-glutamate) (PBLG) was modified with 2-aminoethanol to enhance its hydrophilicity. Controlling the reaction conditions of PBLG and 2-aminoethanol, various types of copoly(gamma-benzyl-L-glutamate, gamma-hydroxyethyl-L-glutamine) film surfaces were obtained. Surface free energy (gamma sv), the dispersive component of gamma sv (gamma dsv), the nondispersive component of gamma sv (gamma psv), and the interfacial free energy of polymer surface with water (gamma sw), which were obtained by using the contact angle measurement and calculation method proposed by Andrade et al., were changed remarkably by the aminolysis. The gamma sv value increased after 2 h of aminolysis from 48.2 (PBLG) to 65.3 dyn/cm and gradually increased to around 70 dyn/cm after 12 h reaction. (gamma dsv) and (gamma psv) changed from 31.0 and 17.2 dyn/cm (PBLG) to 26.5 and 44.3 dyn/cm, respectively. These parameters of the material surfaces, modified over 12 h reaction, were found to be similar to those of the surfaces of canine aorta, vein, and human fibrin membrane. Blood clotting times on these polymer surfaces were comparatively longer than on siliconized glass surfaces.

What Automaticity Deficit? Activation of Lexical Information by Readers with Dyslexia in a Rapid Automatized Naming Stroop-Switch Task

ERIC Educational Resources Information Center

Jones, Manon W.; Snowling, Margaret J.; Moll, Kristina

2016-01-01

Reading fluency is often predicted by rapid automatized naming (RAN) speed, which as the name implies, measures the automaticity with which familiar stimuli (e.g., letters) can be retrieved and named. Readers with dyslexia are considered to have less "automatized" access to lexical information, reflected in longer RAN times compared with…

Probing Protein Structure in Vivo with FRET

PubMed Central

Davis, Trisha; Muller, Eric

2012-01-01

Fluorescence resonance energy transfer (FRET) is widely used to construct probes for cellular activities and to complement two-hybrid results that predict protein-protein interactions. The Yeast Resource Center promotes an underutilized potential of FRET as an in vivo tool to position proteins within low resolution structures derived from electron microscopy. The success of this approach using widefield microscopy depends upon the choice of filter sets, standardized image acquisition, a robust metric and controls matched to the structure under investigation. A comparison of various CFP and YFP filter combinations from Chroma and Semrock demonstrated the strength of the Chroma filters when coupled with our FRET metric, termed FretR. Coupling CFP and YFP to a selection of proteins of known structure allowed us to create a standard curve of FretR versus distance. How well other FRET metrics conform was also evaluated. Finally FretR was linked to an approximation of the efficiency of energy transfer. Together this feature set has allowed us to contribute to our understanding of the organization of the yeast spindle pole body, cohesin complex and gamma-tubulin complex.

GRB Diversity vs. Utility as Cosmological Probes

NASA Technical Reports Server (NTRS)

Norris, J. P.; Scargle, J. D.; Bonnell, J. T.; Nemiroff, R. J.; Young, Richard E. (Technical Monitor)

1997-01-01

Recent detections of apparent gamma-ray burst (GRB) counterparts in optical and radio wavebands strongly favor the cosmological distance scale, at least for some GRBs, opening the possibility of GRBs serving as cosmological probes. But GRBs exhibit great diversity: in total duration; in number, width and pulse configuration; and in pulse and overall spectral evolution. However, it is possible that a portion of this behavior reflects a luminosity distribution, and possible that evolution of with cosmic time introduces dispersion into the average GRB characteristics -- issues analogous to those encountered with quasars. The temporal domain offers a rich avenue to investigate this problem. When corrected for assumed spectral redshift, time dilation of event durations, pulse widths, and intervals between pulses must yield the same time-dilation factor as a function of peak flux, or else a luminosity distribution may be the cause of observed time dilation effects. We describe results of burst analysis using an automated, Bayesian-based algorithm to determine burst temporal characteristics for different peak flux groups, and derived constraints on any physical process that would introduce a luminosity distribution.

Expression of mouse Tla region class I genes in tissues enriched for gamma delta cells.

PubMed

Eghtesady, P; Brorson, K A; Cheroutre, H; Tigelaar, R E; Hood, L; Kronenberg, M

1992-01-01

The Tla region of the BALB/c mouse major histocompatibility complex contains at least 20 class I genes. The function of the products of these genes is unknown, but recent evidence demonstrates that some Tla region gene products could be involved in presentation of antigens to gamma delta T cells. We have generated a set of polymerase chain reaction (PCR) oligonucleotide primers and hybridization probes that permit us to specifically amplify and detect expression of 11 of the 20 BALB/c Tla region genes. cDNA prepared from 12 adult and fetal tissues and from seven cell lines was analyzed. In some cases, northern blot analysis or staining with monoclonal antibodies specific for the Tla-encoded thymus leukemia (TL) antigen were used to confirm the expression pattern of several of the genes as determined by PCR. Some Tla region genes, such as T24d and the members of the T10d/T22d gene pair, are expressed in a wide variety of tissues in a manner similar to the class I transplantation antigens. The members of the TL antigen encoding gene pair, T3d/T18d, are expressed in only a limited number of organs, including several sites enriched for gamma delta T cells. Other Tla region genes, including T1d, T2d, T16d, and T17d, are transcriptionally silent and transcripts from the T8d/T20d gene pair do not undergo proper splicing. In general, sites that contain gamma delta T lymphocytes have Tla region transcripts. The newly identified pattern of expression of the genes analyzed in sites containing gamma delta T cells further extends the list of potential candidates for antigen presentation to gamma delta T cells.

Oxidative potential of logwood and pellet burning particles assessed by a novel profluorescent nitroxide probe.

PubMed

Miljevic, B; Heringa, M F; Keller, A; Meyer, N K; Good, J; Lauber, A; Decarlo, P F; Fairfull-Smith, K E; Nussbaumer, T; Burtscher, H; Prevot, A S H; Baltensperger, U; Bottle, S E; Ristovski, Z D

2010-09-01

This study reports the potential toxicological impact of particles produced during biomass combustion by an automatic pellet boiler and a traditional logwood stove under various combustion conditions using a novel profluorescent nitroxide probe, BPEAnit. This probe is weakly fluorescent but yields strong fluorescence emission upon radical trapping or redox activity. Samples were collected by bubbling aerosol through an impinger containing BPEAnit solution, followed by fluorescence measurement. The fluorescence of BPEAnit was measured for particles produced during various combustion phases: at the beginning of burning (cold start), stable combustion after refilling with the fuel (warm start), and poor burning conditions. For particles produced by the logwood stove under cold-start conditions, significantly higher amounts of reactive species per unit of particulate mass were observed compared to emissions produced during a warm start. In addition, sampling of logwood burning emissions after passing through a thermodenuder at 250 degrees C resulted in an 80-100% reduction of the fluorescence signal of the BPEAnit probe, indicating that the majority of reactive species were semivolatile. Moreover, the amount of reactive species showed a strong correlation with the amount of particulate organic material. This indicates the importance of semivolatile organics in particle-related toxicity. Particle emissions from the pellet boiler, although of similar mass concentration, were not observed to lead to an increase in fluorescence signal during any of the combustion phases.

SkyProbe, monitoring the absolute atmospheric transmission in the optical

NASA Astrophysics Data System (ADS)

Cuillandre, Jean-charles; Magnier, Eugene; Mahoney, William

2011-03-01

Mauna Kea is known for its pristine seeing conditions, but sky transparency can be an issue for science operations since 25% of the night are not photometric, mostly due to high-altitude cirrus. Since 2001, the original single-channel SkyProbe has gathered one exposure every minute during each observing night using a small CCD camera with a very wide field of view (35 sq. deg.) encompassing the region pointed by the telescope for science operations, and exposures long enough (40 seconds) to capture at least 100 stars of Hipparcos' Tychos catalog at high galactic latitudes (and up to 600 stars at low galactic latitudes). A key advantage of SkyProbe over direct thermal infrared imaging detection of clouds, is that it allows an accurate absolute measurement, within 5%, of the true atmospheric absorption by clouds affecting the data being gathered by the telescope's main science instrument. This system has proven crucial for decision making in the CFHT queued service observing (QSO), representing today 80% of the telescope time: science exposures taken in non-photometric conditions are automatically registered for being re-observed later on (at 1/10th of the original exposure time per pointing in the observed filters) to ensure a proper final absolute photometric calibration. The new dual color system (simultaneous B&V bands) will allow a better characterization of the sky properties atop Mauna Kea and will enable a better detection of the thinner cirrus (absorption down to 0.02 mag., i.e. 2%). SkyProbe is operated within the Elixir pipeline, a collection of tools used for handling the CFHT CCD mosaics (CFH12K and MegaCam), from data pre-processing to astrometric and photometric calibration.

Identification and characterization of novel peroxisome proliferator-activated receptor-gamma (PPAR-gamma) transcriptional variants in pig and human.

PubMed

Omi, T; Brenig, B; Spilar Kramer, S; Iwamoto, S; Stranzinger, G; Neuenschwander, S

2005-04-01

The peroxisome proliferator-activated receptor-gamma (PPAR-gamma) is a member of the steroid/thyroid/retinoid receptor superfamily, and is primarily expressed in fat tissue. To date, two major PPAR-gamma isoforms have been identified in pig, PPAR-gamma1 and PPAR-gamma2. Porcine PPAR-gamma1a consists of two leader exons, designated A1 and A2, followed by six exons containing the open reading frame. Here, we report the isolation and characterization of three novel PPAR-gamma1 transcripts. PPAR-gamma1b is derived from exon A1, with exon A2 spliced out. PPAR-gamma1c and PPAR-gamma1d are derived from the new exon, A', containing exon A2 (gamma1c) or without exon A2 (gamma1d). Based on PCR analysis of PAC clones that included sequences from the 5'-untranslated region of the PPAR-gamma gene, the new A' exon is located between the known exons A1 and A2. We also isolated the human homologue to exon A', as well as the two new PPAR-gamma1c and -gamma1d splice variants, from human adipose tissue. Studies of the expression of porcine PPAR-gamma by real time reverse transcription-polymerase chain reaction analysis show that transcripts derived from exon A1 were not expressed at significantly different levels in visceral fat (lamina subserosa) or subcutaneous fat (back fat, inner and outer layer). In contrast, exon A'-derived transcripts were expressed at progressively higher levels in the inner and outer layers of subcutaneous fat than in visceral fat. The same expression pattern was also observed for PPAR-gamma2. We hypothesize that there are three promoters, which differentially regulate PPAR-gamma1 and PPAR-gamma2 gene expression, depending on the specific localization of the fat tissue.

Terrestrial Gamma-Ray Flashes (TGFs)

NASA Technical Reports Server (NTRS)

Fishman, Gerald J.

2010-01-01

This slide presentation reviews the observation of Terrestrial Gamma Ray Flashes (TGFs) by Gamma-Ray Telescopes. These were: (1) BATSE /Compton Observatory, (2) Solar Spectroscopic Imager, (3) AGILE Gamma-ray Telescope, and (4) Gamma-ray Burst Monitor (GBM) on the Fermi Gamma-ray Space Telescope. It contains charts which display the counts over time, a map or the TGFs observed by the Reuven Ramaty High Energy Solar Spectroscopic Imager (RHESSI). and a map showing the latitude and longitude of 85 of the TGFs observed by the Fermi GBM.

Automatic Layout Design for Power Module

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ning, Puqi; Wang, Fei; Ngo, Khai

The layout of power modules is one of the most important elements in power module design, especially for high power densities, where couplings are increased. In this paper, an automatic design process using a genetic algorithm is presented. Some practical considerations are introduced in the optimization of the layout design of the module. This paper presents a process for automatic layout design for high power density modules. Detailed GA implementations are introduced both for outer loop and inner loop. As verified by a design example, the results of the automatic design process presented here are better than those from manualmore » design and also better than the results from a popular design software. This automatic design procedure could be a major step toward improving the overall performance of future layout design.« less

Outer planet entry probe system study. Volume 4: Common Saturn/Uranus probe studies

NASA Technical Reports Server (NTRS)

1973-01-01

Results are summarized of a common scientific probe study to explore the atmospheres of Saturn and Uranus. This was a three-month follow-on effort to the Outer Planet Entry Probe System study. The report presents: (1) a summary, conclusions and recommendations of this study, (2) parametric analysis conducted to support the two system definitions, (3) common Saturn/Uranus probe system definition using the Science Advisory Group's exploratory payload and, (4) common Saturn/Uranus probe system definition using an expanded science complement. Each of the probe system definitions consists of detailed discussions of the mission, science, system and subsystems including telecommunications, data handling, power, pyrotechnics, attitude control, structures, propulsion, thermal control and probe-to-spacecraft integration. References are made to the contents of the first three volumes where it is feasible to do so.

Exploring the nature of the unidentified very-high-energy gamma-ray source HESS J1507-622

NASA Astrophysics Data System (ADS)

Domainko, W.; Ohm, S.

2012-09-01

population of spatially extended VHE gamma-ray emitters with HE gamma-ray counterpart that are located at considerable offsets from the Galactic plane. Future surveys in the VHE gamma-ray range are necessary to probe the presence or absence of such a source population.

Molecular diversity of mesophilic and thermophilic bacteria in a membrane bioreactor determined by fluorescent in situ hybridization with mxaF- and rRNA-targeted probes.

PubMed

Dias, João Carlos T; Silva, Cláudio M; Mounteer, Ann H; Passos, Flavia M L; Linardi, Valter R

2003-01-01

An evaluation of the efficiency of treatment of kraft mill foul condensates in a membrane bioreactor was carried out in the laboratory. Efficiency and rate of methanol removal were quantified at operating temperatures of 35, 45 and 55 degrees C. The structure of the bacterial community present in the reactor biomass at the different operating temperatures was evaluated by in situ hybridization of the biomass samples with fluorescently-labelled probes (FISH) targeting the Eubacteria, the alpha, beta and gamma subclasses of the Proteobacteria, the low G + C content Gram-positive bacteria (Bacillus spp.), while community function was evaluated by in situ hybridization with a methanol dehydrogenase gene (mxaF) probe. Methanol removal efficiency decreased from 99.4 to 92%, and removal rate from 2.69 mg MeOH/l x min to 2.49 mg MeOH/l x min when the operating temperature was increased from 35 to 55 degrees C. This decrease in methanol removal was accompanied by a decrease (from 58% to 42%) in the relative proportion of cells that hybridized with the mxaF probe. The relative proportion of Bacillus spp. increased from 5 to 20% while the proportion of members of the alpha subclass of Proteobacteria decreased from 16% to 6% when the bioreactor operating temperature was raised from 35 to 55 degrees C. The relative proportions of bacteria belonging to the beta (22-25%) and gamma (18-20%) subclasses of the Proteobacteria remained relatively constant regardless of operating temperature. Proteobacteria (alpha, beta and gamma subclasses) and Bacillus spp. represented 61, 67 and 71% of the Eubacteria in the biomass sampled at 35, 45 and 55 degrees C, respectively. The FISH technique was shown to be an efficient method for detection of both structural and functional changes in the bacterial communities that could be related to efficiency of methanol removal in a membrane bioreactor operating at different temperatures.

Gamma ray camera

DOEpatents

Perez-Mendez, Victor

1997-01-01

A gamma ray camera for detecting rays emanating from a radiation source such as an isotope. The gamma ray camera includes a sensor array formed of a visible light crystal for converting incident gamma rays to a plurality of corresponding visible light photons, and a photosensor array responsive to the visible light photons in order to form an electronic image of the radiation therefrom. The photosensor array is adapted to record an integrated amount of charge proportional to the incident gamma rays closest to it, and includes a transparent metallic layer, photodiode consisting of a p-i-n structure formed on one side of the transparent metallic layer, and comprising an upper p-type layer, an intermediate layer and a lower n-type layer. In the preferred mode, the scintillator crystal is composed essentially of a cesium iodide (CsI) crystal preferably doped with a predetermined amount impurity, and the p-type upper intermediate layers and said n-type layer are essentially composed of hydrogenated amorphous silicon (a-Si:H). The gamma ray camera further includes a collimator interposed between the radiation source and the sensor array, and a readout circuit formed on one side of the photosensor array.

The role of diffusion tensor imaging tractography for Gamma Knife thalamotomy planning.

PubMed

Gomes, João Gabriel Ribeiro; Gorgulho, Alessandra Augusta; de Oliveira López, Amanda; Saraiva, Crystian Wilian Chagas; Damiani, Lucas Petri; Pássaro, Anderson Martins; Salvajoli, João Victor; de Oliveira Siqueira, Ludmila; Salvajoli, Bernardo Peres; De Salles, Antônio Afonso Ferreira

2016-12-01

OBJECTIVE The role of tractography in Gamma Knife thalamotomy (GK-T) planning is still unclear. Pyramidal tractography might reduce the risk of radiation injury to the pyramidal tract and reduce motor complications. METHODS In this study, the ventralis intermedius nucleus (VIM) targets of 20 patients were bilaterally defined using Iplannet Stereotaxy Software, according to the anterior commissure-posterior commissure (AC-PC) line and considering the localization of the pyramidal tract. The 40 targets and tractography were transferred as objects to the GammaPlan Treatment Planning System (GP-TPS). New targets were defined, according to the AC-PC line in the functional targets section of the GP-TPS. The target offsets required to maintain the internal capsule (IC) constraint of < 15 Gy were evaluated. In addition, the strategies available in GP-TPS to maintain the minimum conventional VIM target dose at > 100 Gy were determined. RESULTS A difference was observed between the positions of both targets and the doses to the IC. The lateral (x) and the vertical (z) coordinates were adjusted 1.9 mm medially and 1.3 mm cranially, respectively. The targets defined considering the position of the pyramidal tract were more medial and superior, based on the constraint of 15 Gy touching the object representing the IC in the GP-TPS. The best strategy to meet the set constraints was 90° Gamma angle (GA) with automatic shaping of dose distribution; this was followed by 110° GA. The worst GA was 70°. Treatment time was substantially increased by the shaping strategy, approximately doubling delivery time. CONCLUSIONS Routine use of DTI pyramidal tractography might be important to fine-tune GK-T planning. DTI tractography, as well as anisotropy showing the VIM, promises to improve Gamma Knife functional procedures. They allow for a more objective definition of dose constraints to the IC and targeting. DTI pyramidal tractography introduced into the treatment planning may reduce the

Increased gamma band power during movement planning coincides with motor memory retrieval.

PubMed

Thürer, Benjamin; Stockinger, Christian; Focke, Anne; Putze, Felix; Schultz, Tanja; Stein, Thorsten

2016-01-15

The retrieval of motor memory requires a previous memory encoding and subsequent consolidation of the specific motor memory. Previous work showed that motor memory seems to rely on different memory components (e.g., implicit, explicit). However, it is still unknown if explicit components contribute to the retrieval of motor memories formed by dynamic adaptation tasks and which neural correlates are linked to memory retrieval. We investigated the lower and higher gamma bands of subjects' electroencephalography during encoding and retrieval of a dynamic adaptation task. A total of 24 subjects were randomly assigned to a treatment and control group. Both groups adapted to a force field A on day 1 and were re-exposed to the same force field A on day 3 of the experiment. On day 2, treatment group learned an interfering force field B whereas control group had a day rest. Kinematic analyses showed that control group improved their initial motor performance from day 1 to day 3 but treatment group did not. This behavioral result coincided with an increased higher gamma band power in the electrodes over prefrontal areas on the initial trials of day 3 for control but not treatment group. Intriguingly, this effect vanished with the subsequent re-adaptation on day 3. We suggest that improved re-test performance in a dynamic motor adaptation task is contributed by explicit memory and that gamma bands in the electrodes over the prefrontal cortex are linked to these explicit components. Furthermore, we suggest that the contribution of explicit memory vanishes with the subsequent re-adaptation while task automaticity increases. Copyright © 2015 Elsevier Inc. All rights reserved.

Laser-heated emissive plasma probe.

PubMed

Schrittwieser, Roman; Ionita, Codrina; Balan, Petru; Gstrein, Ramona; Grulke, Olaf; Windisch, Thomas; Brandt, Christian; Klinger, Thomas; Madani, Ramin; Amarandei, George; Sarma, Arun K

2008-08-01

Emissive probes are standard tools in laboratory plasmas for the direct determination of the plasma potential. Usually they consist of a loop of refractory wire heated by an electric current until sufficient electron emission. Recently emissive probes were used also for measuring the radial fluctuation-induced particle flux and other essential parameters of edge turbulence in magnetized toroidal hot plasmas [R. Schrittwieser et al., Plasma Phys. Controlled Fusion 50, 055004 (2008)]. We have developed and investigated various types of emissive probes, which were heated by a focused infrared laser beam. Such a probe has several advantages: higher probe temperature without evaporation or melting and thus higher emissivity and longer lifetime, no deformation of the probe in a magnetic field, no potential drop along the probe wire, and faster time response. The probes are heated by an infrared diode laser with 808 nm wavelength and an output power up to 50 W. One probe was mounted together with the lens system on a radially movable probe shaft, and radial profiles of the plasma potential and of its oscillations were measured in a linear helicon discharge.

Formation of gamma'-Ni3Al via the Peritectoid Reaction: gamma plus beta (+Al2O3) equals gamma'(+Al2O3)

NASA Technical Reports Server (NTRS)

Copland, Evan

2008-01-01

The activities of Al and Ni were measured using multi-cell Knudsen effusion-cell mass spectrometry (multi-cell KEMS), over the composition range 8 - 32 at.%Al and temperature range T = 1400 - 1750 K in the Ni-Al-O system. These measurements establish that equilibrium solidification of gamma'-Ni3Al-containing alloys occurs by the eutectic reaction, L (+ Al2O3) = gamma + beta (+ Al2O3), at 1640 plus or minus 1 K and a liquid composition of 24.8 plus or minus 0.2 at.%Al (at an unknown oxygen content). The {gamma + beta + Al2O3} phase field is stable over the temperature range 1633 - 1640 K, and gamma'-Ni3Al forms via the peritectiod, gamma + beta (+ Al2O3) = gamma'(+ Al2O3), at 1633 plus or minus 1 K. This behavior is inconsistent with the current Ni-Al phase diagram and a new diagram is proposed. This new Ni-Al phase diagram explains a number of unusual steady state solidification structures reported previously and provides a much simpler reaction scheme in the vicinity of the gamma'-Ni3Al phase field.

Gamma-ray astrophysics

NASA Technical Reports Server (NTRS)

Stecker, F. W. (Editor); Trombka, J. I. (Editor)

1973-01-01

Conference papers on gamma ray astrophysics are summarized. Data cover the energy region from about 0.3 MeV to a few hundred GeV and theoretical models of production mechanisms that give rise to both galactic and extragalactic gamma rays.

The Gamma-ray Universe through Fermi

NASA Technical Reports Server (NTRS)

Thompson, David J.

2012-01-01

Gamma rays, the most powerful form of light, reveal extreme conditions in the Universe. The Fermi Gamma-ray Space Telescope and its smaller cousin AGILE have been exploring the gamma-ray sky for several years, enabling a search for powerful transients like gamma-ray bursts, novae, solar flares, and flaring active galactic nuclei, as well as long-term studies including pulsars, binary systems, supernova remnants, and searches for predicted sources of gamma rays such as dark matter annihilation. Some results include a stringent limit on Lorentz invariance derived from a gamma-ray burst, unexpected gamma-ray variability from the Crab Nebula, a huge ga.nuna-ray structure associated with the center of our galaxy, surprising behavior from some gamma-ray binary systems, and a possible constraint on some WIMP models for dark matter.

The dorsal medial frontal cortex mediates automatic motor inhibition in uncertain contexts: evidence from combined fMRI and EEG studies.

PubMed

Albares, Marion; Lio, Guillaume; Criaud, Marion; Anton, Jean-Luc; Desmurget, Michel; Boulinguez, Philippe

2014-11-01

Response inhibition is commonly thought to rely on voluntary, reactive, selective, and relatively slow prefrontal mechanisms. In contrast, we suggest here that response inhibition is achieved automatically, nonselectively, within very short delays in uncertain environments. We modified a classical go/nogo protocol to probe context-dependent inhibitory mechanisms. Because no single neuroimaging method can definitely disentangle neural excitation and inhibition, we combined fMRI and EEG recordings in healthy humans. Any stimulus (go or nogo) presented in an uncertain context requiring action restraint was found to evoke activity changes in the supplementary motor complex (SMC) with respect to a control condition in which no response inhibition was required. These changes included: (1) An increase in event-related BOLD activity, (2) an attenuation of the early (170 ms) event related potential generated by a single, consistent source isolated by advanced blind source separation, and (3) an increase in the evoked-EEG Alpha power of this source. Considered together, these results suggest that the BOLD signal evoked by any stimulus in the SMC when the situation is unpredictable can be driven by automatic, nonselective, context-dependent inhibitory activities. This finding reveals the paradoxical mechanisms by which voluntary control of action may be achieved. The ability to provide controlled responses in unpredictable environments would require setting-up the automatic self-inhibitory circuitry within the SMC. Conversely, enabling automatic behavior when the environment becomes predictable would require top-down control to deactivate anticipatorily and temporarily the inhibitory set. Copyright © 2014 Wiley Periodicals, Inc.

Topics in gamma ray astronomy

NASA Technical Reports Server (NTRS)

Ramaty, R.; Lingenfelter, R. E.

1986-01-01

Observations of gamma rays from solar flares, gamma ray bursts, the Galactic center, galactic nucleosynthesis, SS433, and Cygnus X-3, and their effects on astrophysical problems are discussed. It is observed that gamma ray spectra from solar flares are applicable to the study of particle acceleration and confinement and the determination of chemical abundances in the solar atmosphere. The gamma ray lines from the compact galactic object SS433 are utilized to examine the acceleration of jets, and analysis of the gamma ray lines of Cygnus X-3 reveal that particles can be accelerated in compact sources to ultrahigh energies.

The Dependence of Cirrus Gamma Size Distributions Expressed as Volumes in N(sub 0)-Lambda-Mu Phase Space and Bulk Cloud Properties on Environmental Conditions: Results from the Small Ice Particles in Cirrus Experiment (SPARTICUS)

NASA Technical Reports Server (NTRS)

Jackson, Robert C.; McFarquhar, Greg M.; Fridlind, Ann M.; Atlas, Rachel

2015-01-01

The variability of cirrus ice microphysical properties is investigated using observations obtained during the Small Particles in Cirrus (SPARTICUS) campaign. An existing approach that represents a size distribution (SD) as a single gamma function using an ellipsoid of equally realizable solutions in (N(sub 0), lambda, mu) phase space is modified to automatically identify multiple modes in SDs and characterize each mode by such an ellipsoid. The modified approach is applied to ice crystals with maximum dimension D greater than15 micrometers collected by the 2-D stereo and 2-D precipitation probes on the Stratton Park Engineering Company Learjet. The dependencies of N(sub 0), mu, and lambda from each mode, total number concentration, bulk extinction, ice water content (IWC), and mass median maximum dimension D(sub mm) as a function of temperature T and cirrus type are then analyzed. The changes in the observed codependencies between N(sub 0), mu, and lambda, bulk extinction, IWC, and D(sub mm) with environmental conditions indicate that particles were larger at higher T during SPARTICUS. At most two modes were observed in any SD during SPARTICUS, with the average boundary between them at 115 micrometers, similar to past studies not using probes with shatter mitigating tips and artifact removal algorithms. The bimodality of the SDs increased with T. This and the differences in N(sub 0), mu, and lambda between the modes suggest that particles with smaller D nucleated more recently than particles with larger D, which grew via vapor deposition and aggregation. Because smaller crystals, whose concentrations are uncertain, make marginal contributions to higher order moments, the use of higher moments for evaluating model fields is suggested.

A study of interdiffusion in beta + gamma/gamma + gamma prime Ni-Cr-Al. M.S. Thesis. Final Report

NASA Technical Reports Server (NTRS)

Carol, L. A.

1985-01-01

Ternary diffusion in the NiCrAl system at 1200 C was studied with beta + gamma/gamma + gamma prime infinite diffusion couples. Interdiffusion resulted in the formation of complex, multiphase diffusion zones. Concentration/distance profiles for Cr and Al in the phases present in the diffusion zone were measured after 200 hr. The Ni-rich portion of the NiCrAl phase diagram (1200 C) was also determined. From these data, bulk Cr and Al profiles were calculated and translated to diffusion paths on the ternary isotherm. Growth layer kinetics of the layers present in the diffusion zone were also measured.

Innovative SPM Probes for Energy-Storage Science: MWCNT-Nanopipettes to Nanobattery Probes

NASA Astrophysics Data System (ADS)

Larson, Jonathan; Talin, Alec; Pearse, Alexander; Kozen, Alexander; Reutt-Robey, Janice

As energy-storage materials and designs continue to advance, new tools are needed to direct and explore ion insertion/de-insertion at well-defined battery materials interfaces. Scanned probe tips, assembled from actual energy-storage materials, permit SPM measures of local cathode-anode (tip-sample) interactions, including ion transfer. We present examples of ``cathode'' MWCNT-terminated STM probe tips interacting with Li(s)/Si(111) anode substrates. The MWCNT tip functions as both SPM probe and Li-nanopipette,[1] for controlled transport and manipulation of Li. Local field conditions for lithium ionization and transfer are determined and compared to electrostatic models. Additional lithium metallic and oxide tips have been prepared by thin film deposition on conventional W tips, the latter of which effectively functions as a nanobattery. We demonstrate use of these novel probe materials in the local lithiation of low-index Si anode interfaces, probing local barriers for lithium insertion. Prospects and limitations of these novel SPM probes will be discussed. U.S. Department of Energy Award Number DESC0001160.

Development of Mackintosh Probe Extractor

NASA Astrophysics Data System (ADS)

Rahman, Noor Khazanah A.; Kaamin, Masiri; Suwandi, Amir Khan; Sahat, Suhaila; Jahaya Kesot, Mohd

2016-11-01

Dynamic probing is a continuous soil investigation technique, which is one of the simplest soil penetration test. It basically consist of repeatedly driving a metal tipped probe into the ground using a drop weight of fixed mass and travel. Testing was carried out continuously from ground level to the final penetration depth. Once the soil investigation work done, it is difficult to pull out the probe rod from the ground, due to strong soil structure grip against probe cone and prevent the probe rod out from the ground. Thus, in this case, a tool named Extracting Probe was created to assist in the process of retracting the probe rod from the ground. In addition, Extracting Probe also can reduce the time to extract the probe rod from the ground compare with the conventional method. At the same time, it also can reduce manpower cost because only one worker involve to handle this tool compare with conventional method used two or more workers. From experiment that have been done we found that the time difference between conventional tools and extracting probe is significant, average time difference is 155 minutes. In addition the extracting probe can reduce manpower usage, and also labour cost for operating the tool. With all these advantages makes this tool has the potential to be marketed.

Neutron monitoring systems including gamma thermometers and methods of calibrating nuclear instruments using gamma thermometers

DOEpatents

Moen, Stephan Craig; Meyers, Craig Glenn; Petzen, John Alexander; Foard, Adam Muhling

2012-08-07

A method of calibrating a nuclear instrument using a gamma thermometer may include: measuring, in the instrument, local neutron flux; generating, from the instrument, a first signal proportional to the neutron flux; measuring, in the gamma thermometer, local gamma flux; generating, from the gamma thermometer, a second signal proportional to the gamma flux; compensating the second signal; and calibrating a gain of the instrument based on the compensated second signal. Compensating the second signal may include: calculating selected yield fractions for specific groups of delayed gamma sources; calculating time constants for the specific groups; calculating a third signal that corresponds to delayed local gamma flux based on the selected yield fractions and time constants; and calculating the compensated second signal by subtracting the third signal from the second signal. The specific groups may have decay time constants greater than 5.times.10.sup.-1 seconds and less than 5.times.10.sup.5 seconds.

Gamma-ray detector guidance of breast cancer therapy

NASA Astrophysics Data System (ADS)

Ravi, Ananth

2009-12-01

Breast cancer is the most common form of cancer in women. Over 75% of breast cancer patients are eligible for breast conserving therapy. Breast conserving therapy involves a lumpectomy to excise the gross tumour, followed by adjuvant radiation therapy to eradicate residual microscopic disease. Recent advances in the understanding of breast cancer biology and recurrence have presented the opportunity to improve breast conserving therapy techniques. This thesis has explored the potential of gamma-ray detecting technology to improve guidance of both surgical and adjuvant radiation therapy aspects of breast conserving therapy. The task of accurately excising the gross tumour during breast conserving surgery (BCS) is challenging, due to the limited guidance currently available to surgeons. Radioimmuno guided surgery (RIGS) has been investigated to determine its potential to delineate the gross tumour intraoperatively. The effects of varying a set of user controllable parameters on the ability of RIGS to detect and delineate model breast tumours was determined. The parameters studied were: Radioisotope, blood activity concentration, collimator height and energy threshold. The most sensitive combination of parameters was determined to be an 111Indium labelled radiopharmaceutical with a gamma-ray detecting probe collimated to a height of 5 mm and an energy threshold at the Compton backscatter peak. Using these parameters it was found that, for the breast tumour model used, the minimum tumour-to-background ratio required to delineate the tumour edge accurately was 5.2+/-0.4 at a blood activity concentration of 5 kBq/ml. Permanent breast seed implantation (PBSI) is a form of accelerated partial breast irradiation that dramatically reduces the treatment burden of adjuvant radiation therapy on patients. Unfortunately, it is currently difficult to localize the implanted brachytherapy seeds, making it difficult to perform a correction in the event that seeds have been misplaced

Variable path length spectrophotometric probe

DOEpatents

O'Rourke, Patrick E.; McCarty, Jerry E.; Haggard, Ricky A.

1992-01-01

A compact, variable pathlength, fiber optic probe for spectrophotometric measurements of fluids in situ. The probe comprises a probe body with a shaft having a polished end penetrating one side of the probe, a pair of optic fibers, parallel and coterminous, entering the probe opposite the reflecting shaft, and a collimating lens to direct light from one of the fibers to the reflecting surface of the shaft and to direct the reflected light to the second optic fiber. The probe body has an inlet and an outlet port to allow the liquid to enter the probe body and pass between the lens and the reflecting surface of the shaft. A linear stepper motor is connected to the shaft to cause the shaft to advance toward or away from the lens in increments so that absorption measurements can be made at each of the incremental steps. The shaft is sealed to the probe body by a bellows seal to allow freedom of movement of the shaft and yet avoid leakage from the interior of the probe.

Gamma-ray astronomy

NASA Technical Reports Server (NTRS)

Ramaty, R.; Lingenfelter, R. E.

1982-01-01

Cosmic gamma rays, the physical processes responsible for their production and the astrophysical sites from which they were seen are reported. The bulk of the observed gamma ray emission is in the photon energy range from about 0.1 MeV to 1 GeV, where observations are carried out above the atmosphere. There are also, however, gamma ray observations at higher energies obtained by detecting the Cerenkov light produced by the high energy photons in the atmosphere. Gamma ray emission was observed from sources as close as the Sun and the Moon and as distant as the quasar 3C273, as well as from various other galactic and extragalactic sites. The radiation processes also range from the well understood, e.g. energetic particle interactions with matter, to the still incompletely researched, such as radiation transfer in optically thick electron positron plasmas in intense neutron star magnetic fields.

Automatic programming of simulation models

NASA Technical Reports Server (NTRS)

Schroer, Bernard J.; Tseng, Fan T.; Zhang, Shou X.; Dwan, Wen S.

1990-01-01

The concepts of software engineering were used to improve the simulation modeling environment. Emphasis was placed on the application of an element of rapid prototyping, or automatic programming, to assist the modeler define the problem specification. Then, once the problem specification has been defined, an automatic code generator is used to write the simulation code. The following two domains were selected for evaluating the concepts of software engineering for discrete event simulation: manufacturing domain and a spacecraft countdown network sequence. The specific tasks were to: (1) define the software requirements for a graphical user interface to the Automatic Manufacturing Programming System (AMPS) system; (2) develop a graphical user interface for AMPS; and (3) compare the AMPS graphical interface with the AMPS interactive user interface.

Probing Cosmic Dust of the Early Universe through High-Redshift Gamma-Ray Bursts

NASA Astrophysics Data System (ADS)

Liang, S. L.; Li, Aigen

2009-01-01

We explore the extinction properties of the dust in the distant universe through the afterglows of high-redshifted gamma-ray bursts (GRBs) based on the "Drude" model which, unlike previous studies, does not require a prior assumption of template extinction laws. We select GRB 070802 at z ≈ 2.45 (which shows clear evidence for the 2175 Å extinction bump) and GRB 050904 at z ≈ 6.29, the second most distant GRB observed to date. We fit their afterglow spectra to determine the extinction of their host galaxies. We find that (1) their extinction curves differ substantially from that of the Milky Way and the Small and Large Magellanic Clouds (which were widely adopted as template extinction laws in the literature); (2) the 2175 Å extinction feature appears to be also present in GRB 050904 at z ≈ 6.29; and (3) there does not appear to be strong evidence for the dependence of dust extinction on redshifts. The inferred extinction curves are closely reproduced in terms of a mixture of amorphous silicate and graphite, both of which are expected supernova condensates and have been identified in primitive meteorites as presolar grains originating from supernovae (which are considered as the main source of dust at high-z).

Simulated and measured neutron/gamma light output distribution for poly-energetic neutron/gamma sources

NASA Astrophysics Data System (ADS)

Hosseini, S. A.; Zangian, M.; Aghabozorgi, S.

2018-03-01

In the present paper, the light output distribution due to poly-energetic neutron/gamma (neutron or gamma) source was calculated using the developed MCNPX-ESUT-PE (MCNPX-Energy engineering of Sharif University of Technology-Poly Energetic version) computational code. The simulation of light output distribution includes the modeling of the particle transport, the calculation of scintillation photons induced by charged particles, simulation of the scintillation photon transport and considering the light resolution obtained from the experiment. The developed computational code is able to simulate the light output distribution due to any neutron/gamma source. In the experimental step of the present study, the neutron-gamma discrimination based on the light output distribution was performed using the zero crossing method. As a case study, 241Am-9Be source was considered and the simulated and measured neutron/gamma light output distributions were compared. There is an acceptable agreement between the discriminated neutron/gamma light output distributions obtained from the simulation and experiment.

Compact CdZnTe-based gamma camera for prostate cancer imaging

NASA Astrophysics Data System (ADS)

Cui, Yonggang; Lall, Terry; Tsui, Benjamin; Yu, Jianhua; Mahler, George; Bolotnikov, Aleksey; Vaska, Paul; De Geronimo, Gianluigi; O'Connor, Paul; Meinken, George; Joyal, John; Barrett, John; Camarda, Giuseppe; Hossain, Anwar; Kim, Ki Hyun; Yang, Ge; Pomper, Marty; Cho, Steve; Weisman, Ken; Seo, Youngho; Babich, John; LaFrance, Norman; James, Ralph B.

2011-06-01

In this paper, we discuss the design of a compact gamma camera for high-resolution prostate cancer imaging using Cadmium Zinc Telluride (CdZnTe or CZT) radiation detectors. Prostate cancer is a common disease in men. Nowadays, a blood test measuring the level of prostate specific antigen (PSA) is widely used for screening for the disease in males over 50, followed by (ultrasound) imaging-guided biopsy. However, PSA tests have a high falsepositive rate and ultrasound-guided biopsy has a high likelihood of missing small cancerous tissues. Commercial methods of nuclear medical imaging, e.g. PET and SPECT, can functionally image the organs, and potentially find cancer tissues at early stages, but their applications in diagnosing prostate cancer has been limited by the smallness of the prostate gland and the long working distance between the organ and the detectors comprising these imaging systems. CZT is a semiconductor material with wide band-gap and relatively high electron mobility, and thus can operate at room temperature without additional cooling. CZT detectors are photon-electron direct-conversion devices, thus offering high energy-resolution in detecting gamma rays, enabling energy-resolved imaging, and reducing the background of Compton-scattering events. In addition, CZT material has high stopping power for gamma rays; for medical imaging, a few-mm-thick CZT material provides adequate detection efficiency for many SPECT radiotracers. Because of these advantages, CZT detectors are becoming popular for several SPECT medical-imaging applications. Most recently, we designed a compact gamma camera using CZT detectors coupled to an application-specific-integratedcircuit (ASIC). This camera functions as a trans-rectal probe to image the prostate gland from a distance of only 1-5 cm, thus offering higher detection efficiency and higher spatial resolution. Hence, it potentially can detect prostate cancers at their early stages. The performance tests of this camera

Measuring the charged pion polarizability in the gamma gamma -> pi+pi- reaction

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lawrence, David W.; Miskimen, Rory A.; Mushkarenkov, Alexander Nikolaevich

2013-08-01

Development has begun of a new experiment to measure the charged pion polarizabilitymore » $$\\alpha_{\\pi}-\\beta_{\\pi}$$. The charged pion polarizability ranks among the most important tests of low-energy QCD presently unresolved by experiment. Analogous to precision measurements of $$\\pi^{\\circ}\\rightarrow\\gamma\\gamma$$ that test the intrinsic odd-parity (anomalous) sector of QCD, the pion polarizability tests the intrinsic even-parity sector of QCD. The measurement will be performed using the $$\\gamma\\gamma\\rightarrow\\pi^{+{}}\\pi^{-{}}$$ cross section accessed via the Primakoff mechanism on nuclear targets using the GlueX detector in Hall D at Jefferson Lab. The linearly polarized photon source in Hall-D will be utilized to separate the Primakoff cross-section from coherent $$\\rho^{\\circ}$$ production.« less

Future prospects for gamma-ray

NASA Technical Reports Server (NTRS)

Fichtel, C.

1980-01-01

Astrophysical phenomena discussed are: the very energetic and nuclear processes associated with compact objects; astrophysical nucleo-synthesis; solar particle acceleration; the chemical composition of the planets and other bodies of the solar system; the structure of our galaxy; the origin and dynamic pressure effects of the cosmic rays; the high energy particles and energetic processes in other galaxies, especially active ones; and the degree of matter antimater symmetry of the universe. The gamma ray results of GAMMA-I, the gamma ray observatory, the gamma ray burst network, solar polar, and very high energy gamma ray telescopes on the ground provide justification for more sophisticated telescopes.

Gamma ray camera

DOEpatents

Perez-Mendez, V.

1997-01-21

A gamma ray camera is disclosed for detecting rays emanating from a radiation source such as an isotope. The gamma ray camera includes a sensor array formed of a visible light crystal for converting incident gamma rays to a plurality of corresponding visible light photons, and a photosensor array responsive to the visible light photons in order to form an electronic image of the radiation therefrom. The photosensor array is adapted to record an integrated amount of charge proportional to the incident gamma rays closest to it, and includes a transparent metallic layer, photodiode consisting of a p-i-n structure formed on one side of the transparent metallic layer, and comprising an upper p-type layer, an intermediate layer and a lower n-type layer. In the preferred mode, the scintillator crystal is composed essentially of a cesium iodide (CsI) crystal preferably doped with a predetermined amount impurity, and the p-type upper intermediate layers and said n-type layer are essentially composed of hydrogenated amorphous silicon (a-Si:H). The gamma ray camera further includes a collimator interposed between the radiation source and the sensor array, and a readout circuit formed on one side of the photosensor array. 6 figs.

Coexposure of mice to trovafloxacin and lipopolysaccharide, a model of idiosyncratic hepatotoxicity, results in a unique gene expression profile and interferon gamma-dependent liver injury.

PubMed

Shaw, Patrick J; Ditewig, Amy C; Waring, Jeffrey F; Liguori, Michael J; Blomme, Eric A; Ganey, Patricia E; Roth, Robert A

2009-01-01

The antibiotic trovafloxacin (TVX) has caused severe idiosyncratic hepatotoxicity in people, whereas levofloxacin (LVX) has not. Mice cotreated with TVX and lipopolysaccharide (LPS), but not with LVX and LPS, develop severe hepatocellular necrosis. Mice were treated with TVX and/or LPS, and hepatic gene expression changes were measured before liver injury using gene array. Hepatic gene expression profiles from mice treated with TVX/LPS clustered differently from those treated with LPS or TVX alone. Several of the probe sets expressed differently in TVX/LPS-treated mice were involved in interferon (IFN) signaling and the janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway. A time course of plasma concentrations of IFN-gamma and interleukin (IL)-18, which directly induces IFN-gamma production, revealed that both cytokines were selectively increased in TVX/LPS-treated mice. Both IL-18(-/-) and IFN-gamma(-/-) mice were significantly protected from TVX/LPS-induced liver injury. In addition, IFN-gamma(-/-) mice had decreased plasma concentrations of tumor necrosis factor-alpha, IL-18, and IL-1beta when compared to wild-type mice. In conclusion, the altered expression of genes involved in IFN signaling in TVX/LPS-treated mice led to the finding that IL-18 and IFN-gamma play a critical role in TVX/LPS-induced liver injury.

Ten bar probe technical summary. [feasibility of outer planet common atmospheric probe

NASA Technical Reports Server (NTRS)

Ellis, T. R.