Prompt gamma-ray imaging for small animals

NASA Astrophysics Data System (ADS)

Xu, Libai

codes GEANT4 or MCNP5, to predict results and investigate the feasibility of this new imaging idea. Benchmark experiments have been conducted to test the capability of the code to simulate prompt gamma rays, which are produced by following the nuclear structures of each irradiated isotope, and coincidence counting techniques, which are considered the most important improvement in neutron-related gamma-ray detection applications to reduce gamma background and improve system signal-to-noise ratios. With coincidence prompt gamma rays available, two major imaging techniques, electronic collimations and mechanic collimations, are implemented in the simulation to illustrate the feasibility of imaging elemental distribution by this new technique. The expectation maximization algorithm is employed in electronic collimation to reconstruct images. The common SPECT imaging algorithms are used in mechanical collimation to get an image. Several critical topics concerning practical applications have already been discussed, such as the radiation dose to the mouse and the detection efficiency of high-energy gamma rays. The funding of this work is provided by the Center for Engineering Application of Radioisotopes (CEAR) at North Carolina State University (NCSU) and Nuclear Engineering Education Research.

Focal Plane Detectors for the Advanced Gamma-Ray Imaging System (AGIS)

NASA Astrophysics Data System (ADS)

Wagner, Robert G.; AGIS Photodetector Group; Byrum, K.; Drake, G.; Falcone, A.; Funk, S.; Horan, D.; Mukherjee, R.; Tajima, H.; Williams, D.

2008-03-01

The Advanced Gamma-Ray Imaging System (AGIS) is a concept for the next generation observatory in ground-based very high energy gamma-ray astronomy. It is being designed to achieve a significant improvement in sensitivity compared to current Imaging Air Cherenkov Telescope (IACT) Arrays. One of the main requirements in order that AGIS fulfill this goal will be to achieve higher angular resolution than current IACTs. Simulations show that a substantial improvement in angular resolution may be achieved if the pixel size is reduced to less than 0.05 deg, i.e. two to three times smaller than the pixel size of current IACT cameras. With finer pixelation and the plan to deploy on the order of 100 telescopes in the AGIS array, the channel count will exceed 1,000,000 imaging pixels. High uniformity and long mean time-to-failure will be important aspects of a successful photodetector technology choice. Here we present alternatives being considered for AGIS, including both silicon photomultipliers (SiPMs) and multi-anode photomultipliers (MAPMTs). Results from laboratory testing of MAPMTs and SiPMs are presented along with results from the first incorporation of these devices in cameras on test bed Cherenkov telescopes.

Photodetectors for the Advanced Gamma-ray Imaging System (AGIS)

NASA Astrophysics Data System (ADS)

Wagner, Robert G.; Advanced Gamma-ray Imaging System AGIS Collaboration

2010-03-01

The Advanced Gamma-Ray Imaging System (AGIS) is a concept for the next generation very high energy gamma-ray observatory. Design goals include an order of magnitude better sensitivity, better angular resolution, and a lower energy threshold than existing Cherenkov telescopes. Each telescope is equipped with a camera that detects and records the Cherenkov-light flashes from air showers. The camera is comprised of a pixelated focal plane of blue sensitive and fast (nanosecond) photon detectors that detect the photon signal and convert it into an electrical one. Given the scale of AGIS, the camera must be reliable and cost effective. The Schwarzschild-Couder optical design yields a smaller plate scale than present-day Cherenkov telescopes, enabling the use of more compact, multi-pixel devices, including multianode photomultipliers or Geiger avalanche photodiodes. We present the conceptual design of the focal plane for the camera and results from testing candidate! focal plane sensors.

Gamma Ray Imaging of Inertial Confinement Fusion Experiments

NASA Astrophysics Data System (ADS)

Wilde, Carl; Volegov, Petr; Geppert-Kleinrath, Verena; Danly, Christopher; Merrill, Frank; Simpson, Raspberry; Fittinghoff, David; Grim, Gary; NIF Nuclear Diagnostic Team Team; Advanced Imaging Team Team

2016-10-01

Experiments consisting of an ablatively driven plastic (CH) shell surrounding a deuterium tritium (DT) fuel region are routinely performed at the National Ignition Facility (NIF). Neutrons produced in the burning fuel in-elastically scatter with carbon atoms in the plastic shell producing 4.4 MeV gamma rays. Providing a spatially resolved distribution of the origin of these gammas can inform models of ablator physics and also provide a bounding volume for the cold fuel (un-burned DT fuel) region. Using the NIF neutron imaging system hardware, initial studies have been performed of the feasibility of imaging these gamma rays. A model of the system has been developed to inform under which experimental conditions this measurement can be made. Presented here is an analysis of the prospects for this diagnostic probe and a proposed set of modifications to the NIF neutron imaging line-of-site to efficiently enable this measurement.

Development and Evaluation of Real-Time Volumetric Compton Gamma-Ray Imaging

NASA Astrophysics Data System (ADS)

Barnowski, Ross Wegner

An approach to gamma-ray imaging has been developed that enables near real-time volumetric (3D) imaging of unknown environments thus improving the utility of gamma-ray imaging for source-search and radiation mapping applications. The approach, herein dubbed scene data fusion (SDF), is based on integrating mobile radiation imagers with real time tracking and scene reconstruction algorithms to enable a mobile mode of operation and 3D localization of gamma-ray sources. The real-time tracking allows the imager to be moved throughout the environment or around a particular object of interest, obtaining the multiple perspectives necessary for standoff 3D imaging. A 3D model of the scene, provided in real-time by a simultaneous localization and mapping (SLAM) algorithm, can be incorporated into the image reconstruction reducing the reconstruction time and improving imaging performance. The SDF concept is demonstrated in this work with a Microsoft Kinect RGB-D sensor, a real-time SLAM solver, and two different mobile gamma-ray imaging platforms. The first is a cart-based imaging platform known as the Volumetric Compton Imager (VCI), comprising two 3D position-sensitive high purity germanium (HPGe) detectors, exhibiting excellent gamma-ray imaging characteristics, but with limited mobility due to the size and weight of the cart. The second system is the High Efficiency Multimodal Imager (HEMI) a hand-portable gamma-ray imager comprising 96 individual cm3 CdZnTe crystals arranged in a two-plane, active-mask configuration. The HEMI instrument has poorer energy and angular resolution than the VCI, but is truly hand-portable, allowing the SDF concept to be tested in multiple environments and for more challenging imaging scenarios. An iterative algorithm based on Compton kinematics is used to reconstruct the gamma-ray source distribution in all three spatial dimensions. Each of the two mobile imaging systems are used to demonstrate SDF for a variety of scenarios, including

Camera Concepts for the Advanced Gamma-Ray Imaging System (AGIS)

NASA Astrophysics Data System (ADS)

Nepomuk Otte, Adam

2009-05-01

The Advanced Gamma-Ray Imaging System (AGIS) is a concept for the next generation observatory in ground-based very high energy gamma-ray astronomy. Design goals are ten times better sensitivity, higher angular resolution, and a lower energy threshold than existing Cherenkov telescopes. Each telescope is equipped with a camera that detects and records the Cherenkov-light flashes from air showers. The camera is comprised of a pixelated focal plane of blue sensitive and fast (nanosecond) photon detectors that detect the photon signal and convert it into an electrical one. The incorporation of trigger electronics and signal digitization into the camera are under study. Given the size of AGIS, the camera must be reliable, robust, and cost effective. We are investigating several directions that include innovative technologies such as Geiger-mode avalanche-photodiodes as a possible detector and switched capacitor arrays for the digitization.

The Advanced Gamma-ray Imaging System (AGIS): Galactic Astrophysics

NASA Astrophysics Data System (ADS)

Digel, Seth William; Funk, S.; Kaaret, P. E.; Tajima, H.; AGIS Collaboration

2010-03-01

The Advanced Gamma-ray Imaging System (AGIS), a concept for a next-generation atmospheric Cherenkov telescope array, would provide unprecedented sensitivity and resolution in the energy range >50 GeV, allowing great advances in the understanding of the populations and physics of sources of high-energy gamma rays in the Milky Way. Extrapolation based on the known source classes and the performance parameters for AGIS indicates that a survey of the Galactic plane with AGIS will reveal hundreds of TeV sources in exquisite detail, for population studies of a variety of source classes, and detailed studies of individual sources. AGIS will be able to study propagation effects on the cosmic rays produced by Galactic sources by detecting the diffuse glow from their interactions in dense interstellar gas. AGIS will complement and extend results now being obtained in the GeV range with the Fermi mission, by providing superior angular resolution and sensitivity to variability on short time scales, and of course by probing energies that Fermi cannot reach.

Impact of Image Noise on Gamma Index Calculation

NASA Astrophysics Data System (ADS)

Chen, M.; Mo, X.; Parnell, D.; Olivera, G.; Galmarini, D.; Lu, W.

2014-03-01

Purpose: The Gamma Index defines an asymmetric metric between the evaluated image and the reference image. It provides a quantitative comparison that can be used to indicate sample-wised pass/fail on the agreement of the two images. The Gamma passing/failing rate has become an important clinical evaluation tool. However, the presence of noise in the evaluated and/or reference images may change the Gamma Index, hence the passing/failing rate, and further, clinical decisions. In this work, we systematically studied the impact of the image noise on the Gamma Index calculation. Methods: We used both analytic formulation and numerical calculations in our study. The numerical calculations included simulations and clinical images. Three different noise scenarios were studied in simulations: noise in reference images only, in evaluated images only, and in both. Both white and spatially correlated noises of various magnitudes were simulated. For clinical images of various noise levels, the Gamma Index of measurement against calculation, calculation against measurement, and measurement against measurement, were evaluated. Results: Numerical calculations for both the simulation and clinical data agreed with the analytic formulations, and the clinical data agreed with the simulations. For the Gamma Index of measurement against calculation, its distribution has an increased mean and an increased standard deviation as the noise increases. On the contrary, for the Gamma index of calculation against measurement, its distribution has a decreased mean and stabilized standard deviation as the noise increases. White noise has greater impact on the Gamma Index than spatially correlated noise. Conclusions: The noise has significant impact on the Gamma Index calculation and the impact is asymmetric. The Gamma Index should be reported along with the noise levels in both reference and evaluated images. Reporting of the Gamma Index with switched roles of the images as reference and

A novel phoswich imaging detector for simultaneous beta and coincidence-gamma imaging of plant leaves.

PubMed

Wu, Heyu; Tai, Yuan-Chuan

2011-09-07

To meet the growing demand for functional imaging technology for use in studying plant biology, we are developing a novel technique that permits simultaneous imaging of escaped positrons and coincidence gammas from annihilation of positrons within an intake leaf. The multi-modality imaging system will include two planar detectors: one is a typical PET detector array and the other is a phoswich imaging detector that detects both beta and gamma. The novel phoswich detector is made of a plastic scintillator, a lutetium oxyorthosilicate (LSO) array, and a position sensitive photomultiplier tube (PS-PMT). The plastic scintillator serves as a beta detector, while the LSO array serves as a gamma detector and light guide that couples scintillation light from the plastic detector to the PMT. In our prototype, the PMT signal was fed into the Siemens QuickSilver electronics to achieve shaping and waveform sampling. Pulse-shape discrimination based on the detectors' decay times (2.1 ns for plastic and 40 ns for LSO) was used to differentiate beta and gamma events using the common PMT signals. Using our prototype phoswich detector, we simultaneously measured a beta image and gamma events (in single mode). The beta image showed a resolution of 1.6 mm full-width-at-half-maximum using F-18 line sources. Because this shows promise for plant-scale imaging, our future plans include development of a fully functional simultaneous beta-and-coincidence-gamma imager with sub-millimeter resolution imaging capability for both modalities.

The Advanced Gamma-ray Imaging System (AGIS): Telescope Mechanical Designs

NASA Astrophysics Data System (ADS)

Guarino, V.; Buckley, J.; Byrum, K.; Falcone, A.; Fegan, S.; Finley, J.; Hanna, D.; Horan, D.; Kaaret, P.; Konopelko, A.; Krawczynski, H.; Krennrich, F.; Wagner, R.; Woods, M.; Vassiliev, V.

2008-04-01

The concept of a future ground-based gamma-ray observatory, AGIS, in the energy range 40 GeV-100 TeV is based on an array of sim 100 imaging atmospheric Cherenkov telescopes (IACTs). The anticipated improvements of AGIS sensitivity, angular resolution and reliability of operation impose demanding technological and cost requirements on the design of IACTs. The relatively inexpensive Davies-Cotton telescope design has been used in ground-based gamma-ray astronomy for almost fifty years and is an excellent option. We are also exploring alternative designs and in this submission we focus on the recent mechanical design of a two-mirror telescope with a Schwarzschild-Couder (SC) optical system. The mechanical structure provides support points for mirrors and camera. The design was driven by the requirement of minimizing the deflections of the mirror support structures. The structure is also designed to be able to slew in elevation and azimuth at 10 degrees/sec.

Investigation of the possibility of gamma-ray diagnostic imaging of target compression at NIF

PubMed Central

Lemieux, Daniel A.; Baudet, Camille; Grim, Gary P.; Barber, H. Bradford; Miller, Brian W.; Fasje, David; Furenlid, Lars R.

2013-01-01

The National Ignition Facility at Lawrence Livermore National Laboratory is the world’s leading facility to study the physics of igniting plasmas. Plasmas of hot deuterium and tritium, undergo d(t,n)α reactions that produce a 14.1 MeV neutron and 3.5 MeV a particle, in the center of mass. As these neutrons pass through the materials surrounding the hot core, they may undergo subsequent (n,x) reactions. For example, 12C(n,n’γ)12C reactions occur in remnant debris from the polymer ablator resulting in a significant fluence of 4.44 MeV gamma-rays. Imaging of these gammas will enable the determination of the volumetric size and symmetry of the ablation; large size and high asymmetry is expected to correlate with poor compression and lower fusion yield. Results from a gamma-ray imaging system are expected to be complimentary to a neutron imaging diagnostic system already in place at the NIF. This paper describes initial efforts to design a gamma-ray imaging system for the NIF using the existing neutron imaging system as a baseline for study. Due to the cross-section and expected range of ablator areal densities, the gamma flux should be approximately 10−3 of the neutron flux. For this reason, care must be taken to maximize the efficiency of the gamma-ray imaging system because it will be gamma starved. As with the neutron imager, use of pinholes and/or coded apertures are anticipated. Along with aperture and detector design, the selection of an appropriate scintillator is discussed. The volume of energy deposition of the interacting 4.44 MeV gamma-rays is a critical parameter limiting the imaging system spatial resolution. The volume of energy deposition is simulated with GEANT4, and plans to measure the volume of energy deposition experimentally are described. Results of tests on a pixellated LYSO scintillator are also presented. PMID:23420688

Investigation of the possibility of gamma-ray diagnostic imaging of target compression at NIF

NASA Astrophysics Data System (ADS)

Lemieux, Daniel A.; Baudet, Camille; Grim, Gary P.; Barber, H. Bradford; Miller, Brian W.; Fasje, David; Furenlid, Lars R.

2011-09-01

The National Ignition Facility at Lawrence Livermore National Laboratory is the world's leading facility to study the physics of igniting plasmas. Plasmas of hot deuterium and tritium, undergo d(t,n)α reactions that produce a 14.1 MeV neutron and 3.5 MeV a particle, in the center of mass. As these neutrons pass through the materials surrounding the hot core, they may undergo subsequent (n,x) reactions. For example, 12C(n,n'γ)12C reactions occur in remnant debris from the polymer ablator resulting in a significant fluence of 4.44 MeV gamma-rays. Imaging of these gammas will enable the determination of the volumetric size and symmetry of the ablation; large size and high asymmetry is expected to correlate with poor compression and lower fusion yield. Results from a gamma-ray imaging system are expected to be complimentary to a neutron imaging diagnostic system already in place at the NIF. This paper describes initial efforts to design a gamma-ray imaging system for the NIF using the existing neutron imaging system as a baseline for study. Due to the cross-section and expected range of ablator areal densities, the gamma flux should be approximately 10-3 of the neutron flux. For this reason, care must be taken to maximize the efficiency of the gamma-ray imaging system because it will be gamma starved. As with the neutron imager, use of pinholes and/or coded apertures are anticipated. Along with aperture and detector design, the selection of an appropriate scintillator is discussed. The volume of energy deposition of the interacting 4.44 MeV gamma-rays is a critical parameter limiting the imaging system spatial resolution. The volume of energy deposition is simulated with GEANT4, and plans to measure the volume of energy deposition experimentally are described. Results of tests on a pixellated LYSO scintillator are also presented.

Investigation of the possibility of gamma-ray diagnostic imaging of target compression at NIF.

PubMed

Lemieux, Daniel A; Baudet, Camille; Grim, Gary P; Barber, H Bradford; Miller, Brian W; Fasje, David; Furenlid, Lars R

2011-09-23

The National Ignition Facility at Lawrence Livermore National Laboratory is the world's leading facility to study the physics of igniting plasmas. Plasmas of hot deuterium and tritium, undergo d(t,n)α reactions that produce a 14.1 MeV neutron and 3.5 MeV a particle, in the center of mass. As these neutrons pass through the materials surrounding the hot core, they may undergo subsequent (n,x) reactions. For example, (12)C(n,n'γ)(12)C reactions occur in remnant debris from the polymer ablator resulting in a significant fluence of 4.44 MeV gamma-rays. Imaging of these gammas will enable the determination of the volumetric size and symmetry of the ablation; large size and high asymmetry is expected to correlate with poor compression and lower fusion yield. Results from a gamma-ray imaging system are expected to be complimentary to a neutron imaging diagnostic system already in place at the NIF. This paper describes initial efforts to design a gamma-ray imaging system for the NIF using the existing neutron imaging system as a baseline for study. Due to the cross-section and expected range of ablator areal densities, the gamma flux should be approximately 10(-3) of the neutron flux. For this reason, care must be taken to maximize the efficiency of the gamma-ray imaging system because it will be gamma starved. As with the neutron imager, use of pinholes and/or coded apertures are anticipated. Along with aperture and detector design, the selection of an appropriate scintillator is discussed. The volume of energy deposition of the interacting 4.44 MeV gamma-rays is a critical parameter limiting the imaging system spatial resolution. The volume of energy deposition is simulated with GEANT4, and plans to measure the volume of energy deposition experimentally are described. Results of tests on a pixellated LYSO scintillator are also presented.

The Advanced Gamma-ray Imaging System (AGIS): Camera Electronics Designs

NASA Astrophysics Data System (ADS)

Tajima, Hiroyasu; Buckley, J.; Byrum, K.; Drake, G.; Falcone, A.; Funk, S.; Holder, J.; Horan, D.; Krawczynski, H.; Ong, R.; Swordy, S.; Wagner, R.; Wakely, S.; Williams, D.; Camera Electronics Working Group; AGIS Collaboration

2008-03-01

AGIS, a next generation of atmospheric Cherenkov telescope arrays, aims to achieve a sensitivity level of a milliCrab for gamma-ray observations in in the energy band of 40 GeV to 100 TeV. Such improvement requires cost reduction of individual components with high reliability in order to equip the order of 100 telescopes necessary to achieve the sensitivity goal. We are exploring several design concepts to reduce the cost of camera electronics while improving their performance. These design concepts include systems based on multi-channel waveform sampling ASIC optimized for AGIS, a system based on IIT (image intensifier tube) for large channel (order of 1 million channels) readout as well as a multiplexed FADC system based on the current VERITAS readout design. Here we present trade-off studies of these design concepts.

The Advanced Gamma-ray Imaging System (AGIS) Telescope Optical System Designs

NASA Astrophysics Data System (ADS)

Bugaev, V.; Buckley, J.; Diegel, S.; Falcone, A.; Fegan, S.; Finley, J.; Guarino, V.; Hanna, D.; Kaaret, P.; Konopelko, A.; Krawczynski, H.; Ramsey, B.; Romani, R.; Vassiliev, V.; Weekes, T.

2008-12-01

AGIS is a conceptual design for a future ground-based gamma-ray observatory operating in the energy range 25 GeV-100 TeV, which is based on an array of ~20-100 imaging atmospheric Cherenkov telescopes (IACTs). The desired improvement in sensitivity, angular resolution, and reliability of operation of AGIS imposes demanding technological and cost requirements on the design of the IACTs. We are considering several options for the optical system (OS) of the AGIS telescopes, which include the traditional Davies-Cotton design as well as novel two-mirror design. Emerging mirror production technologies based on replication processes such as cold and hot glass slumping, cured carbon fiber reinforced plastic (CFRP), and electroforming provide new opportunities for cost-effective solutions for the design of the OS.

MONICA: A Compact, Portable Dual Gamma Camera System for Mouse Whole-Body Imaging

PubMed Central

Xi, Wenze; Seidel, Jurgen; Karkareka, John W.; Pohida, Thomas J.; Milenic, Diane E.; Proffitt, James; Majewski, Stan; Weisenberger, Andrew G.; Green, Michael V.; Choyke, Peter L.

2009-01-01

Introduction We describe a compact, portable dual-gamma camera system (named “MONICA” for MObile Nuclear Imaging CAmeras) for visualizing and analyzing the whole-body biodistribution of putative diagnostic and therapeutic single photon emitting radiotracers in animals the size of mice. Methods Two identical, miniature pixelated NaI(Tl) gamma cameras were fabricated and installed “looking up” through the tabletop of a compact portable cart. Mice are placed directly on the tabletop for imaging. Camera imaging performance was evaluated with phantoms and field performance was evaluated in a weeklong In-111 imaging study performed in a mouse tumor xenograft model. Results Tc-99m performance measurements, using a photopeak energy window of 140 keV ± 10%, yielded the following results: spatial resolution (FWHM at 1-cm), 2.2-mm; sensitivity, 149 cps/MBq (5.5 cps/μCi); energy resolution (FWHM), 10.8%; count rate linearity (count rate vs. activity), r2 = 0.99 for 0–185 MBq (0–5 mCi) in the field-of-view (FOV); spatial uniformity, < 3% count rate variation across the FOV. Tumor and whole-body distributions of the In-111 agent were well visualized in all animals in 5-minute images acquired throughout the 168-hour study period. Conclusion Performance measurements indicate that MONICA is well suited to whole-body single photon mouse imaging. The field study suggests that inter-device communications and user-oriented interfaces included in the MONICA design facilitate use of the system in practice. We believe that MONICA may be particularly useful early in the (cancer) drug development cycle where basic whole-body biodistribution data can direct future development of the agent under study and where logistical factors, e.g. limited imaging space, portability, and, potentially, cost are important. PMID:20346864

The Use of Gamma-Ray Imaging to Improve Portal Monitor Performance

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ziock, Klaus-Peter; Collins, Jeff; Fabris, Lorenzo

2008-01-01

We have constructed a prototype, rapid-deployment portal monitor that uses visible-light and gamma-ray imaging to allow simultaneous monitoring of multiple lanes of traffic from the side of a roadway. Our Roadside Tracker uses automated target acquisition and tracking (TAT) software to identify and track vehicles in visible light images. The field of view of the visible camera overlaps with and is calibrated to that of a one-dimensional gamma-ray imager. The TAT code passes information on when vehicles enter and exit the system field of view and when they cross gamma-ray pixel boundaries. Based on this in-formation, the gamma-ray imager "harvests"more » the gamma-ray data specific to each vehicle, integrating its radiation signature for the entire time that it is in the field of view. In this fashion we are able to generate vehicle-specific radiation signatures and avoid source confusion problems that plague nonimaging approaches to the same problem.« less

The Advanced Gamma-ray Imaging System (AGIS): Topological Array Trigger

NASA Astrophysics Data System (ADS)

Smith, Andrew W.

2010-03-01

AGIS is a concept for the next-generation ground-based gamma-ray observatory. It will be an array of 36 imaging atmospheric Cherenkov telescopes (IACTs) sensitive in the energy range from 50 GeV to 200 TeV. The required improvements in sensitivity, angular resolution, and reliability of operation relative to the present generation instruments imposes demanding technological and cost requirements on the design of the telescopes and on the triggering and readout systems for AGIS. To maximize the capabilities of large arrays of IACTs with a low energy threshold, a wide field of view and a low background rate, a sophisticated array trigger is required. We outline the status of the development of a stereoscopic array trigger that calculates image parameters and correlates them across a subset of telescopes. Field Programmable Gate Arrays (FPGAs) implement the real-time pattern recognition to suppress cosmic rays and night-sky background events. A proof of principle system is being developed to run at camera trigger rates up to 10MHz and array-level rates up to 10kHz.

The Advanced Gamma-ray Imaging System (AGIS): Camera Electronics Designs

NASA Astrophysics Data System (ADS)

Tajima, H.; Buckley, J.; Byrum, K.; Drake, G.; Falcone, A.; Funk, S.; Holder, J.; Horan, D.; Krawczynski, H.; Ong, R.; Swordy, S.; Wagner, R.; Williams, D.

2008-04-01

AGIS, a next generation of atmospheric Cherenkov telescope arrays, aims to achieve a sensitivity level of a milliCrab for gamma-ray observations in the energy band of 40 GeV to 100 TeV. Such improvement requires cost reduction of individual components with high reliability in order to equip the order of 100 telescopes necessary to achieve the sensitivity goal. We are exploring several design concepts to reduce the cost of camera electronics while improving their performance. These design concepts include systems based on multi-channel waveform sampling ASIC optimized for AGIS, a system based on IIT (image intensifier tube) for large channel (order of 1 million channels) readout as well as a multiplexed FADC system based on the current VERITAS readout design. Here we present trade-off in the studies of these design concepts.

The Advanced Gamma-ray Imaging System (AGIS): Extragalactic Science

NASA Astrophysics Data System (ADS)

Coppi, Paolo S.; Extragalactic Science Working Group; AGIS Collaboration

2010-03-01

The Advanced Gamma-ray Imaging System (AGIS), a proposed next-generation array of Cherenkov telescopes, will provide an unprecedented view of the high energy universe. We discuss how AGIS, with its larger effective area, improved angular resolution, lower threshold, and an order of magnitude increase in sensitivity, impacts the extragalactic science possible in the very high energy domain. Likely source classes detectable by AGIS include AGN, GRBs, clusters, star-forming galaxies, and possibly the cascade radiation surrounding powerful cosmic accelerators. AGIS should see many of the sources discovered by Fermi. With its better sensitivity and angular resolution, AGIS then becomes a key instrument for identifying and characterizing Fermi survey sources, the majority of which will have limited Fermi photon statistics and localizations.

Nuclear medicine imaging system

DOEpatents

Bennett, G.W.; Brill, A.B.; Bizais, Y.J.C.; Rowe, R.W.; Zubal, I.G.

1983-03-11

It is an object of this invention to provide a nuclear imaging system having the versatility to do positron annihilation studies, rotating single or opposed camera gamma emission studies, and orthogonal gamma emission studies. It is a further object of this invention to provide an imaging system having the capability for orthogonal dual multipinhole tomography. It is another object of this invention to provide a nuclear imaging system in which all available energy data, as well as patient physiological data, are acquired simultaneously in list mode.

Handheld real-time volumetric 3-D gamma-ray imaging

NASA Astrophysics Data System (ADS)

Haefner, Andrew; Barnowski, Ross; Luke, Paul; Amman, Mark; Vetter, Kai

2017-06-01

This paper presents the concept of real-time fusion of gamma-ray imaging and visual scene data for a hand-held mobile Compton imaging system in 3-D. The ability to obtain and integrate both gamma-ray and scene data from a mobile platform enables improved capabilities in the localization and mapping of radioactive materials. This not only enhances the ability to localize these materials, but it also provides important contextual information of the scene which once acquired can be reviewed and further analyzed subsequently. To demonstrate these concepts, the high-efficiency multimode imager (HEMI) is used in a hand-portable implementation in combination with a Microsoft Kinect sensor. This sensor, in conjunction with open-source software, provides the ability to create a 3-D model of the scene and to track the position and orientation of HEMI in real-time. By combining the gamma-ray data and visual data, accurate 3-D maps of gamma-ray sources are produced in real-time. This approach is extended to map the location of radioactive materials within objects with unknown geometry.

Display gamma is an important factor in Web image viewing

NASA Astrophysics Data System (ADS)

Zhang, Xuemei; Lavin, Yingmei; Silverstein, D. Amnon

2001-06-01

We conducted a perceptual image preference experiment over the web to find our (1) if typical computer users have significant variations in their display gamma settings, and (2) if so, do the gamma settings have significant perceptual effect on the appearance of images in their web browsers. The digital image renderings used were found to have preferred tone characteristics from a previous lab- controlled experiment. They were rendered with 4 different gamma settings. The subjects were asked to view the images over the web, with their own computer equipment and web browsers. The subjects werewe asked to view the images over the web, with their own computer equipment and web browsers. The subjects made pair-wise subjective preference judgements on which rendering they liked bets for each image. Each subject's display gamma setting was estimated using a 'gamma estimator' tool, implemented as a Java applet. The results indicated that (1) the user's gamma settings, as estimated in the experiment, span a wide range from about 1.8 to about 3.0; (2) the subjects preferred images that werewe rendered with a 'correct' gamma value matching their display setting. Subjects disliked images rendered with a gamma value not matching their displays'. This indicates that display gamma estimation is a perceptually significant factor in web image optimization.

Mercuric iodide room-temperature array detectors for gamma-ray imaging

DOE Office of Scientific and Technical Information (OSTI.GOV)

Patt, B.

Significant progress has been made recently in the development of mercuric iodide detector arrays for gamma-ray imaging, making real the possibility of constructing high-performance small, light-weight, portable gamma-ray imaging systems. New techniques have been applied in detector fabrication and then low noise electronics which have produced pixel arrays with high-energy resolution, high spatial resolution, high gamma stopping efficiency. Measurements of the energy resolution capability have been made on a 19-element protypical array. Pixel energy resolutions of 2.98% fwhm and 3.88% fwhm were obtained at 59 keV (241-Am) and 140-keV (99m-Tc), respectively. The pixel spectra for a 14-element section of themore » data is shown together with the composition of the overlapped individual pixel spectra. These techniques are now being applied to fabricate much larger arrays with thousands of pixels. Extension of these principles to imaging scenarios involving gamma-ray energies up to several hundred keV is also possible. This would enable imaging of the 208 keV and 375-414 keV 239-Pu and 240-Pu structures, as well as the 186 keV line of 235-U.« less

Gamma-Ray Focusing Optics for Small Animal Imaging

NASA Technical Reports Server (NTRS)

Pivovaroff, M. J.; Barber, W. C.; Craig, W. W.; Hasegawa, B. H.; Ramsey, B. D.; Taylor, C.

2004-01-01

There is a well-established need for high-resolution radionuclide imaging techniques that provide non-invasive measurement of physiological function in small animals. We, therefore, have begun developing a small animal radionuclide imaging system using grazing incidence mirrors to focus low-energy gamma-rays emitted by I-125, and other radionuclides. Our initial prototype optic, fabricated from thermally-formed glass, demonstrated a resolution of 1500 microns, consistent with the performance predicted by detailed simulations. More recently, we have begun constructing mirrors using a replication technique that reduces low spatial frequency errors in the mirror surface, greatly improving the resolution. Each technique offers particular advantages: e.g., multilayer coatings are easily deposited on glass, while superior resolution is possible with replicated optics. Scaling the results from our prototype optics, which only have a few nested shells, to system where the lens has a full complement of several tens of nested shells, a sensitivity of approx. 1 cps/micro Ci is possible, with the exact number dependent on system magnification and radionuclide species. (Higher levels of efficiency can be obtained with multi-optic imaging systems.) The gamma-ray lens will achieve a resolution as good as 100 microns, independent of the final sensitivity. The combination of high spatial resolution and modest sensitivity will enable in vivo single photon emission imaging studies in small animals.

The Advanced Gamma-ray Imaging System (AGIS): Telescope Optical System Designs

NASA Astrophysics Data System (ADS)

Hanna, David S.; Buckley, J. H.; Falcone, A.; Fegan, S.; Finley, J.; Guarino, V.; Kaaret, P.; Krawczynski, H.; Krennrich, F.; Konopelko, A.; Romani, R.; Vassilliev, V.; Optical System Working Group; AGIS Collaboration

2008-03-01

The concept of a future ground-based gamma-ray observatory, AGIS, in the energy range 20 GeV-200 TeV is based on an array of 50-200 imaging atmospheric Cherenkov telescopes (IACTs). The anticipated improvement of AGIS sensitivity, angular resolution, and reliability of operation imposes demanding technological and cost requirements on the design of IACTs. In this submission we will focus on the optical system (OS) of AGIS telescopes and consider options which include traditional Davies-Cotton and the other prime-focus telescope designs, as well as the novel two-mirror aplanatic OS originally proposed by Schwarzschild. The emerging new mirror production technologies based on replication processes, such as cold and hot glass slumping, cured CFRP, and electroforming, provide new opportunities for cost effective solutions for the design of the OS. We initially evaluate capabilities of these mirror fabrication methods for the AGIS project.

Gamma-ray imaging system for real-time measurements in nuclear waste characterisation

NASA Astrophysics Data System (ADS)

Caballero, L.; Albiol Colomer, F.; Corbi Bellot, A.; Domingo-Pardo, C.; Leganés Nieto, J. L.; Agramunt Ros, J.; Contreras, P.; Monserrate, M.; Olleros Rodríguez, P.; Pérez Magán, D. L.

2018-03-01

A compact, portable and large field-of-view gamma camera that is able to identify, locate and quantify gamma-ray emitting radioisotopes in real-time has been developed. The device delivers spectroscopic and imaging capabilities that enable its use it in a variety of nuclear waste characterisation scenarios, such as radioactivity monitoring in nuclear power plants and more specifically for the decommissioning of nuclear facilities. The technical development of this apparatus and some examples of its application in field measurements are reported in this article. The performance of the presented gamma-camera is also benchmarked against other conventional techniques.

Focal Plane Detectors for the Advanced Gamma-Ray Imaging System (AGIS)

NASA Astrophysics Data System (ADS)

Otte, A. N.; Byrum, K.; Drake, G.; Falcone, A.; Funk, S.; Horan, D.; Mukherjee, R.; Smith, A.; Tajima, H.; Wagner, R. G.; Williams, D. A.

2008-12-01

The Advanced Gamma-Ray Imaging System (AGIS) is a concept for the next generation observatory in ground-based very high energy gamma-ray astronomy. Design goals are ten times better sensitivity, higher angular resolution, and a lower energy threshold than existing Cherenkov telescopes. Simulations show that a substantial improvement in angular resolution may be achieved if the pixel diameter is reduced to the order of 0.05 deg, i.e. two to three times smaller than the pixel diameter of current Cherenkov telescope cameras. At these dimensions, photon detectors with smaller physical dimensions can be attractive alternatives to the classical photomultiplier tube (PMT). Furthermore, the operation of an experiment with the size of AGIS requires photon detectors that are among other things more reliable, more durable, and possibly higher efficiency photon detectors. Alternative photon detectors we are considering for AGIS include both silicon photomultipliers (SiPMs) and multi-anode photomultipliers (MAPMTs). Here we present results from laboratory testing of MAPMTs and SiPMs along with results from the first incorporation of these devices into cameras on test bed Cherenkov telescopes.

A small field of view camera for hybrid gamma and optical imaging

NASA Astrophysics Data System (ADS)

Lees, J. E.; Bugby, S. L.; Bhatia, B. S.; Jambi, L. K.; Alqahtani, M. S.; McKnight, W. R.; Ng, A. H.; Perkins, A. C.

2014-12-01

The development of compact low profile gamma-ray detectors has allowed the production of small field of view, hand held imaging devices for use at the patient bedside and in operating theatres. The combination of an optical and a gamma camera, in a co-aligned configuration, offers high spatial resolution multi-modal imaging giving a superimposed scintigraphic and optical image. This innovative introduction of hybrid imaging offers new possibilities for assisting surgeons in localising the site of uptake in procedures such as sentinel node detection. Recent improvements to the camera system along with results of phantom and clinical imaging are reported.

Developments in mercuric iodide gamma ray imaging

DOE Office of Scientific and Technical Information (OSTI.GOV)

Patt, B.E.; Beyerle, A.G.; Dolin, R.C.

A mercuric iodide gamma-ray imaging array and camera system previously described has been characterized for spatial and energy resolution. Based on this data a new camera is being developed to more fully exploit the potential of the array. Characterization results and design criterion for the new camera will be presented. 2 refs., 7 figs.

The Advanced Gamma-ray Imaging System (AGIS)

NASA Astrophysics Data System (ADS)

Buckley, James

2008-04-01

We describe a concept for a ˜km^2 ground-based gamma-ray experiment (AGIS) comprised of an array of ˜100 imaging atmospheric Cherenkov telescopes achieving a sensitivity an order of magnitude better than the current generation of space or ground-based instruments in the energy range of 40 GeV to ˜100 TeV. We present the scientific drivers for AGIS including the prospects for contributions to understanding extragalactic sources such as nearby galaxies, active galaxies, galaxy clusters and GRB; galactic sources such as X-ray binaries, supernova remnants, and pulsar wind nebulae; as well as probes of fundamental physics including indirectly detecting dark matter and probing TeV-scale physics. With the current generation of atmospheric Cherenkov telescope arrays, TeV astronomy has become well established, with the number TeV gamma-ray sources now nearing 100, including many unidentified and serendipitous sources. Improvements in the instantaneous field of view, angular resolution, effective area and energy resolution of AGIS are certain to provide great scientific returns in high energy astrophysics as well as opening up new discovery space. Here we present an overview of the ongoing design studies for AGIS including the optimization of array parameters as well as an overview of the technical drivers for the observatory.

Gamma-ray tracking method for pet systems

DOEpatents

Mihailescu, Lucian; Vetter, Kai M.

2010-06-08

Gamma-ray tracking methods for use with granular, position sensitive detectors identify the sequence of the interactions taking place in the detector and, hence, the position of the first interaction. The improved position resolution in finding the first interaction in the detection system determines a better definition of the direction of the gamma-ray photon, and hence, a superior source image resolution. A PET system using such a method will have increased efficiency and position resolution.

Gamma-Ray Imaging for Explosives Detection

NASA Technical Reports Server (NTRS)

deNolfo, G. A.; Hunter, S. D.; Barbier, L. M.; Link, J. T.; Son, S.; Floyd, S. R.; Guardala, N.; Skopec, M.; Stark, B.

2008-01-01

We describe a gamma-ray imaging camera (GIC) for active interrogation of explosives being developed by NASA/GSFC and NSWCICarderock. The GIC is based on the Three-dimensional Track Imager (3-DTI) technology developed at GSFC for gamma-ray astrophysics. The 3-DTI, a large volume time-projection chamber, provides accurate, approx.0.4 mm resolution, 3-D tracking of charged particles. The incident direction of gamma rays, E, > 6 MeV, are reconstructed from the momenta and energies of the electron-positron pair resulting from interactions in the 3-DTI volume. The optimization of the 3-DTI technology for this specific application and the performance of the GIC from laboratory tests is presented.

Gamma ray imager on the DIII-D tokamak

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pace, D. C., E-mail: pacedc@fusion.gat.com; Taussig, D.; Eidietis, N. W.

2016-04-15

A gamma ray camera is built for the DIII-D tokamak [J. Luxon, Nucl. Fusion 42, 614 (2002)] that provides spatial localization and energy resolution of gamma flux by combining a lead pinhole camera with custom-built detectors and optimized viewing geometry. This diagnostic system is installed on the outer midplane of the tokamak such that its 123 collimated sightlines extend across the tokamak radius while also covering most of the vertical extent of the plasma volume. A set of 30 bismuth germanate detectors can be secured in any of the available sightlines, allowing for customizable coverage in experiments with runaway electronsmore » in the energy range of 1–60 MeV. Commissioning of the gamma ray imager includes the quantification of electromagnetic noise sources in the tokamak machine hall and a measurement of the energy spectrum of background gamma radiation. First measurements of gamma rays coming from the plasma provide a suitable testbed for implementing pulse height analysis that provides the energy of detected gamma photons.« less

Gamma ray imager on the DIII-D tokamak

DOE PAGES

Pace, D. C.; Cooper, C. M.; Taussig, D.; ...

2016-04-13

A gamma ray camera is built for the DIII-D tokamak [J. Luxon, Nucl. Fusion 42, 614 (2002)] that provides spatial localization and energy resolution of gamma flux by combining a lead pinhole camera with custom-built detectors and optimized viewing geometry. This diagnostic system is installed on the outer midplane of the tokamak such that its 123 collimated sightlines extend across the tokamak radius while also covering most of the vertical extent of the plasma volume. A set of 30 bismuth germanate detectors can be secured in any of the available sightlines, allowing for customizable coverage in experiments with runaway electronsmore » in the energy range of 1- 60 MeV. Commissioning of the gamma ray imager includes the quantification of electromagnetic noise sources in the tokamak machine hall and a measurement of the energy spectrum of background gamma radiation. In conclusion, first measurements of gamma rays coming from the plasma provide a suitable testbed for implementing pulse height analysis that provides the energy of detected gamma photons.« less

Mathematical Investigation of Gamma Ray and Neutron Absorption Grid Patterns for Homeland Defense Related Fourier Imaging Systems

NASA Technical Reports Server (NTRS)

Boccio, Dona

2003-01-01

Terrorist suitcase nuclear devices typically using converted Soviet tactical nuclear warheads contain several kilograms of plutonium. This quantity of plutonium emits a significant number of gamma rays and neutrons as it undergoes radioactive decay. These gamma rays and neutrons normally penetrate ordinary matter to a significant distance. Unfortunately this penetrating quality of the radiation makes imaging with classical optics impractical. However, this radiation signature emitted by the nuclear source may be sufficient to be imaged from low-flying aerial platforms carrying Fourier imaging systems. The Fourier imaging system uses a pair of co-aligned absorption grids to measure a selected range of spatial frequencies from an object. These grids typically measure the spatial frequency in only one direction at a time. A grid pair that looks in all directions simultaneously would be an improvement over existing technology. A number of grid pairs governed by various parameters were investigated to solve this problem. By examining numerous configurations, it became apparent that an appropriate spiral pattern could be made to work. A set of equations was found to describe a grid pattern that produces straight fringes. Straight fringes represent a Fourier transform of a point source at infinity. An inverse Fourier transform of this fringe pattern would provide an accurate image (location and intensity) of a point source.

The Advanced Gamma-ray Imaging System (AGIS): Schwarzschild-Couder (SC) Telescope Mechanical and Optical System Design

NASA Astrophysics Data System (ADS)

Byrum, Karen L.; Vassiliev, V.; AGIS Collaboration

2010-03-01

AGIS is a concept for the next-generation ground-based gamma-ray observatory. It will be an array of 36 imaging atmospheric Cherenkov telescopes (IACTs) sensitive in the energy range from 50 GeV to 200 TeV. The required improvements in sensitivity, angular resolution, and reliability of operation relative to the present generation instruments imposes demanding technological and cost requirements on the design of AGIS telescopes. In this submission, we outline the status of the development of the optical and mechanical systems for a novel Schwarzschild-Couder two-mirror aplanatic telescope. This design can provide a field of view and angular resolution significantly better to those offered by the traditional Davies-Cotton optics utilized in present-day IACTs. Other benefits of the novel design include isochronous focusing and compatibility with cost-effective, high quantum efficiency image sensors such as multi-anode PMTs, silicon PMTs (SiPMs), or image intensifiers.

The Advanced Gamma-ray Imaging System (AGIS)-Science Highlights

NASA Astrophysics Data System (ADS)

Buckley, J.; Coppi, P.; Digel, S.; Funk, S.; Krawczynski, H.; Krennrich, F.; Pohl, M.; Romani, R.; Vassiliev, V.

2008-12-01

The Advanced Gamma-ray Imaging System (AGIS), a future gamma-ray telescope consisting of an array of ~50 atmospheric Cherenkov telescopes distributed over an area of ~1 km2, will provide a powerful new tool for exploring the high-energy universe. The order-of-magnitude increase in sensitivity and improved angular resolution could provide the first detailed images of γ-ray emission from other nearby galaxies or galaxy clusters. The large effective area will provide unprecedented sensitivity to short transients (such as flares from AGNs and GRBs) probing both intrinsic spectral variability (revealing the details of the acceleration mechanism and geometry) as well as constraining the high-energy dispersion in the velocity of light (probing the structure of spacetime and Lorentz invariance). A wide field of view (~4 times that of current instruments) and excellent angular resolution (several times better than current instruments) will allow for an unprecedented survey of the Galactic plane, providing a deep unobscured survey of SNRs, X-ray binaries, pulsar-wind nebulae, molecular cloud complexes and other sources. The differential flux sensitivity of ~10-13 erg cm-2 sec-1 will rival the most sensitive X-ray instruments for these extended Galactic sources. The excellent capabilities of AGIS at energies below 100 GeV will provide sensitivity to AGN and GRBs out to cosmological redshifts, increasing the number of AGNs detected at high energies from about 20 to more than 100, permitting population studies that will provide valuable insights into both a unified model for AGN and a detailed measurement of the effects of intergalactic absorption from the diffuse extragalactic background light. A new instrument with fast-slewing wide-field telescopes could provide detections of a number of long-duration GRBs providing important physical constraints from this new spectral component. The new array will also have excellent background rejection and very large effective area

Study on detecting spatial distribution of neutrons and gamma rays using a multi-imaging plate system.

PubMed

Tanaka, Kenichi; Sakurai, Yoshinori; Endo, Satoru; Takada, Jun

2014-06-01

In order to measure the spatial distributions of neutrons and gamma rays separately using the imaging plate, the requirement for the converter to enhance specific component was investigated with the PHITS code. Consequently, enhancing fast neutrons using recoil protons from epoxy resin was not effective due to high sensitivity of the imaging plate to gamma rays. However, the converter of epoxy resin doped with (10)B was found to have potential for thermal and epithermal neutrons, and graphite for gamma rays. Copyright © 2014 Elsevier Ltd. All rights reserved.

The Advanced Gamma-ray Imageing System (AGIS): Simulation Design Studies

NASA Astrophysics Data System (ADS)

Bugaev, V.; Buckley, J.; Digel, S.; Fegan, S.; Funk, S.; Konopelko, A.; Krawczynski, H.; Lebohec, S.; Maier, G.; Vassiliev, V.

2008-04-01

We present design studies for AGIS, a proposed array of ˜100 imaging atmospheric Cherenkov telescopes for gamma-rays astronomy in the 40GeV to 100 TeV energy regime. We describe optimization studies for the array configuration, pixel size and field of view aimed at achieving the best sensitivity over the entire energy range and best angular resolution for a fixed project total cost.

Multimodal US-gamma imaging using collaborative robotics for cancer staging biopsies.

PubMed

Esposito, Marco; Busam, Benjamin; Hennersperger, Christoph; Rackerseder, Julia; Navab, Nassir; Frisch, Benjamin

2016-09-01

The staging of female breast cancer requires detailed information about the level of cancer spread through the lymphatic system. Common practice to obtain this information for patients with early-stage cancer is sentinel lymph node (SLN) biopsy, where LNs are radioactively identified for surgical removal and subsequent histological analysis. Punch needle biopsy is a less invasive approach but suffers from the lack of combined anatomical and nuclear information. We present and evaluate a system that introduces live collaborative robotic 2D gamma imaging in addition to live 2D ultrasound to identify SLNs in the surrounding anatomy. The system consists of a robotic arm equipped with both a gamma camera and a stereoscopic tracking system that monitors the position of an ultrasound probe operated by the physician. The arm cooperatively places the gamma camera parallel to the ultrasound imaging plane to provide live multimodal visualization and guidance. We validate the system by evaluating the target registration errors between fused nuclear and US image data in a phantom consisting of two spheres, one of which is filled with radioactivity. Medical experts perform punch biopsies on agar-gelatine phantoms with complex configurations of hot and cold lesions to provide a qualitative and quantitative evaluation of the system. The average point registration error for the overlay is [Formula: see text] mm. The time of the entire procedure was reduced by 36 %, with 80v of the biopsies being successful. The users' feedback was very positive, and the system was deemed to be very intuitive, with handling similar to classic US-guided needle biopsy. We present and evaluate the first medical collaborative robotic imaging system. Feedback from potential users for SLN punch needle biopsy is encouraging. Ongoing work investigates the clinical feasibility with more complex and realistic phantoms.

‘Gamma Anna’: a classroom demonstration for teaching the concepts of gamma imaging

NASA Astrophysics Data System (ADS)

Wolff, Nicola; Griffiths, Jennifer; Yerworth, Rebecca

2017-01-01

Gamma imaging is at the interface of medicine and physics and thus its teaching is important in both fields. Pedagogic literature highlights the benefits of interactive demonstrations in teaching: an increase in enjoyment and interest, as well as improvement in academic achievement. However gamma imaging uses radioactive sources, which are potentially dangerous and thus their use is tightly controlled. We have developed a demonstration which uses a localised exothermic reaction within a rag doll as an analogue of radioactivity. This can be safely used in classrooms to demonstrate the principles of gamma imaging. The tool is easy to make, cheap, robust and portable. The supplementary material in this paper gives teacher notes and a description of how to make the rag doll demonstrator. We have tested the tool using six participants, acting as ‘teachers’, who carried out the demonstration and described the doll as easy to use, and the ‘tumour’ clearly identifiable. The teaching tool was separately demonstrated to a group of 12 GCSE physics students and a group of 12 medical students. Feedback showed increased student engagement, enjoyment and understanding of gamma imaging. Previous research has shown that these benefits have an impact on learning and academic outcomes.

Gamma-ray detectors for breast imaging

NASA Astrophysics Data System (ADS)

Williams, Mark B.; Goode, Allen R.; Majewski, Stan; Steinbach, Daniela; Weisenberger, Andrew G.; Wojcik, Randolph F.; Farzanpay, Farzin

1997-07-01

Breast cancer is the most common cancer of American women and is the leading cause of cancer-related death among women aged 15 - 54; however recent years have shown that early detection using x-ray mammography can lead to a high probability of cure. However, because of mammography's low positive predictive value, surgical or core biopsy is typically required for diagnosis. In addition, the low radiographic contrast of many nonpalpable breast masses, particularly among women with radiographically dense breasts, results in an overall rate of 10% to 25% for missed tumors. Nuclear imaging of the breast using single gamma emitters (scintimammography) such as (superscript 99m)Tc, or positron emitters such as F-18- fluorodeoxyglucose (FDG) for positron emission tomography (PET), can provide information on functional or metabolic tumor activity that is complementary to the structural information of x-ray mammography, thereby potentially reducing the number of unnecessary biopsies and missed cancers. This paper summarizes recent data on the efficacy of scintimammography using conventional gamma cameras, and describes the development of dedicated detectors for gamma emission breast imaging. The detectors use new, high density crystal scintillators and large area position sensitive photomultiplier tubes (PSPMTs). Detector design, imaging requirements, and preliminary measured imaging performance are discussed.

Application of gamma imaging techniques for the characterisation of position sensitive gamma detectors

NASA Astrophysics Data System (ADS)

Habermann, T.; Didierjean, F.; Duchêne, G.; Filliger, M.; Gerl, J.; Kojouharov, I.; Li, G.; Pietralla, N.; Schaffner, H.; Sigward, M.-H.

2017-11-01

A device to characterize position-sensitive germanium detectors has been implemented at GSI. The main component of this so called scanning table is a gamma camera that is capable of producing online 2D images of the scanned detector by means of a PET technique. To calibrate the gamma camera Compton imaging is employed. The 2D data can be processed further offline to obtain depth information. Of main interest is the response of the scanned detector in terms of the digitized pulse shapes from the preamplifier. This is an important input for pulse-shape analysis algorithms as they are in use for gamma tracking arrays in gamma spectroscopy. To validate the scanning table, a comparison of its results with a second scanning table implemented at the IPHC Strasbourg is envisaged. For this purpose a pixelated germanium detector has been scanned.

Development of a three-layer phoswich alpha-beta-gamma imaging detector

NASA Astrophysics Data System (ADS)

Yamamoto, Seiichi; Ishibashi, Hiroyuki

2015-06-01

For radiation monitoring at the sites of such nuclear power plant accidents as Fukushima Daiichi, radiation detectors are needed not only for gamma photons but also for alpha and beta particles because some nuclear fission products emit beta particles and gamma photons and some nuclear fuels contain plutonium that emits alpha particles. In some applications, imaging detectors are required to detect the distribution of plutonium particles that emit alpha particles and radiocesium in foods that emits beta particles and gamma photons. To solve these requirements, we developed an imaging detector that can measure the distribution of alpha and beta particles as well as gamma photons. The imaging detector consists of three-layer scintillators optically coupled to each other and to a position sensitive photomultiplier tube (PSPMT). The first layer, which is made of a thin plastic scintillator (decay time: 5 ns), detects alpha particles. The second layer, which is made of a thin Gd2SiO5 (GSO) scintillator with 1.5 mol% Ce (decay time: 35 ns), detects beta particles. The third layer made of a thin GSO scintillator with 0.4 mol% Ce (decay time: 70 ns) detects gamma photons. Using pulse shape discrimination, the images of these layers can be separated. The position information is calculated by the Anger principle from 8×8 anode signals from the PSPMT. The images for the alpha and beta particles and the gamma photons are individually formed by the pulse shape discriminations for each layer. We detected alpha particle images in the first layer and beta particle images in the second layer. Gamma photon images were detected in the second and third layers. The spatial resolution for the alpha and beta particles was 1.25 mm FWHM and less than 2 mm FWHM for the gamma photons. We conclude that our developed alpha-beta-gamma imaging detector is promising for imaging applications not only for the environmental monitoring of radionuclides but also for medical and molecular imaging.

Minimum Detectable Activity for Tomographic Gamma Scanning System

DOE Office of Scientific and Technical Information (OSTI.GOV)

Venkataraman, Ram; Smith, Susan; Kirkpatrick, J. M.

2015-01-01

For any radiation measurement system, it is useful to explore and establish the detection limits and a minimum detectable activity (MDA) for the radionuclides of interest, even if the system is to be used at far higher values. The MDA serves as an important figure of merit, and often a system is optimized and configured so that it can meet the MDA requirements of a measurement campaign. The non-destructive assay (NDA) systems based on gamma ray analysis are no exception and well established conventions, such the Currie method, exist for estimating the detection limits and the MDA. However, the Tomographicmore » Gamma Scanning (TGS) technique poses some challenges for the estimation of detection limits and MDAs. The TGS combines high resolution gamma ray spectrometry (HRGS) with low spatial resolution image reconstruction techniques. In non-imaging gamma ray based NDA techniques measured counts in a full energy peak can be used to estimate the activity of a radionuclide, independently of other counting trials. However, in the case of the TGS each “view” is a full spectral grab (each a counting trial), and each scan consists of 150 spectral grabs in the transmission and emission scans per vertical layer of the item. The set of views in a complete scan are then used to solve for the radionuclide activities on a voxel by voxel basis, over 16 layers of a 10x10 voxel grid. Thus, the raw count data are not independent trials any more, but rather constitute input to a matrix solution for the emission image values at the various locations inside the item volume used in the reconstruction. So, the validity of the methods used to estimate MDA for an imaging technique such as TGS warrant a close scrutiny, because the pair-counting concept of Currie is not directly applicable. One can also raise questions as to whether the TGS, along with other image reconstruction techniques which heavily intertwine data, is a suitable method if one expects to measure samples whose

Mini gamma camera, camera system and method of use

DOEpatents

Majewski, Stanislaw; Weisenberger, Andrew G.; Wojcik, Randolph F.

2001-01-01

A gamma camera comprising essentially and in order from the front outer or gamma ray impinging surface: 1) a collimator, 2) a scintillator layer, 3) a light guide, 4) an array of position sensitive, high resolution photomultiplier tubes, and 5) printed circuitry for receipt of the output of the photomultipliers. There is also described, a system wherein the output supplied by the high resolution, position sensitive photomultipiler tubes is communicated to: a) a digitizer and b) a computer where it is processed using advanced image processing techniques and a specific algorithm to calculate the center of gravity of any abnormality observed during imaging, and c) optional image display and telecommunications ports.

Simulation based evaluation of the designs of the Advanced Gamma-ray Imageing System (AGIS)

NASA Astrophysics Data System (ADS)

Bugaev, Slava; Buckley, James; Digel, Seth; Funk, Stephen; Konopelko, Alex; Krawczynski, Henric; Lebohec, Steohan; Maier, Gernot; Vassiliev, Vladimir

2009-05-01

The AGIS project under design study, is a large array of imaging atmospheric Cherenkov telescopes for gamma-rays astronomy between 40GeV and 100 TeV. In this paper we present the ongoing simulation effort to model the considered design approaches as a function of the main parameters such as array geometry, telescope optics and camera design in such a way the gamma ray observation capabilities can be optimized against the overall project cost.

The Advanced Gamma-ray Imaging System (AGIS): Schwarzschild-Couder (SC) Telescope Mechanical and Optical System Design

NASA Astrophysics Data System (ADS)

Guarino, V.; Vassiliev, V.; Buckley, J.; Byrum, K.; Falcone, A.; Fegan, S.; Finley, J.; Hanna, D.; Kaaret, P.; Konopelko, A.; Krawczynski, H.; Krennrich, F.; Romani, R.; Wagner, R.; Woods, M.

2009-05-01

The concept of a future ground-based gamma-ray observatory, AGIS, in the energy range 20 GeV to 200 TeV is based on an array of 50-100 imaging atmospheric Cherenkov telescopes (IACTs). The anticipated improvement of AGIS sensitivity, angular resolution, and reliability of operation imposes demanding technological and cost requirements on the design of IACTs. In this submission, we focus on the optical and mechanical systems for a novel Schwarzschild-Couder two-mirror aplanatic optical system originally proposed by Schwarzschild. Emerging new mirror production technologies based on replication processes, such as cold and hot glass slumping, cured CFRP, and electroforming, provide new opportunities for cost effective solutions for the design of the optical system. We explore capabilities of these mirror fabrication methods for the AGIS project and alignment methods for optical systems. We also study a mechanical structure which will provide support points for mirrors and camera design driven by the requirement of minimizing the deflections of the mirror support structures.

The Gamma-Ray Imager GRI

NASA Astrophysics Data System (ADS)

Wunderer, Cornelia B.; GRI Collaboration

2006-09-01

Observations of the gamma-ray sky reveal the most powerful sources and the most violent events in the Universe. While at lower wavebands the observed emission is generally dominated by thermal processes, the gamma-ray sky provides us with a view on the non-thermal Universe. Here particles are accelerated to extreme relativistic energies by mechanisms which are still poorly understood, and nuclear reactions are synthesizing the basic constituents of our world. Cosmic accelerators and cosmic explosions are the major science themes that are addressed in the gamma-ray regime. With the INTEGRAL observatory, ESA has provided a unique tool to the astronomical community revealing hundreds of sources, new classes of objects, extraordinary views of antimatter annihilation in our Galaxy, and fingerprints of recent nucleosynthesis processes. While INTEGRAL provides the global overview over the soft gamma-ray sky, there is a growing need to perform deeper, more focused investigations of gamma-ray sources. In soft X-rays a comparable step was taken going from the Einstein and the EXOSAT satellites to the Chandra and XMM/Newton observatories. Technological advances in the past years in the domain of gamma-ray focusing using Laue diffraction and multilayer coated mirror techniques have paved the way towards a gamma-ray mission, providing major improvements compared to past missions regarding sensitivity and angular resolution. Such a future Gamma-Ray Imager will allow to study particle acceleration processes and explosion physics in unprecedented detail, providing essential clues on the innermost nature of the most violent and most energetic processes in the Universe.

Compact CdZnTe-based gamma camera for prostate cancer imaging

NASA Astrophysics Data System (ADS)

Cui, Yonggang; Lall, Terry; Tsui, Benjamin; Yu, Jianhua; Mahler, George; Bolotnikov, Aleksey; Vaska, Paul; De Geronimo, Gianluigi; O'Connor, Paul; Meinken, George; Joyal, John; Barrett, John; Camarda, Giuseppe; Hossain, Anwar; Kim, Ki Hyun; Yang, Ge; Pomper, Marty; Cho, Steve; Weisman, Ken; Seo, Youngho; Babich, John; LaFrance, Norman; James, Ralph B.

2011-06-01

In this paper, we discuss the design of a compact gamma camera for high-resolution prostate cancer imaging using Cadmium Zinc Telluride (CdZnTe or CZT) radiation detectors. Prostate cancer is a common disease in men. Nowadays, a blood test measuring the level of prostate specific antigen (PSA) is widely used for screening for the disease in males over 50, followed by (ultrasound) imaging-guided biopsy. However, PSA tests have a high falsepositive rate and ultrasound-guided biopsy has a high likelihood of missing small cancerous tissues. Commercial methods of nuclear medical imaging, e.g. PET and SPECT, can functionally image the organs, and potentially find cancer tissues at early stages, but their applications in diagnosing prostate cancer has been limited by the smallness of the prostate gland and the long working distance between the organ and the detectors comprising these imaging systems. CZT is a semiconductor material with wide band-gap and relatively high electron mobility, and thus can operate at room temperature without additional cooling. CZT detectors are photon-electron direct-conversion devices, thus offering high energy-resolution in detecting gamma rays, enabling energy-resolved imaging, and reducing the background of Compton-scattering events. In addition, CZT material has high stopping power for gamma rays; for medical imaging, a few-mm-thick CZT material provides adequate detection efficiency for many SPECT radiotracers. Because of these advantages, CZT detectors are becoming popular for several SPECT medical-imaging applications. Most recently, we designed a compact gamma camera using CZT detectors coupled to an application-specific-integratedcircuit (ASIC). This camera functions as a trans-rectal probe to image the prostate gland from a distance of only 1-5 cm, thus offering higher detection efficiency and higher spatial resolution. Hence, it potentially can detect prostate cancers at their early stages. The performance tests of this camera

GRI: The Gamma-Ray Imager mission

NASA Astrophysics Data System (ADS)

Knödlseder, Jürgen; GRI Consortium

With the INTEGRAL observatory ESA has provided a unique tool to the astronomical community revealing hundreds of sources, new classes of objects, extraordinary views of antimatter annihilation in our Galaxy, and fingerprints of recent nucleosynthesis processes. While INTEGRAL provides the global overview over the soft gamma-ray sky, there is a growing need to perform deeper, more focused investigations of gamma-ray sources. In soft X-rays a comparable step was taken going from the Einstein and the EXOSAT satellites to the Chandra and XMM/Newton observatories. Technological advances in the past years in the domain of gamma-ray focusing using Laue diffraction have paved the way towards a new gamma-ray mission, providing major improvements regarding sensitivity and angular resolution. Such a future Gamma-Ray Imager will allow studies of particle acceleration processes and explosion physics in unprecedented detail, providing essential clues on the innermost nature of the most violent and most energetic processes in the Universe.

GRI: The Gamma-Ray Imager mission

NASA Astrophysics Data System (ADS)

Knödlseder, Jürgen; GRI Consortium

2006-06-01

With the INTEGRAL observatory, ESA has provided a unique tool to the astronomical community revealing hundreds of sources, new classes of objects, extraordinary views of antimatter annihilation in our Galaxy, and fingerprints of recent nucleosynthesis processes. While INTEGRAL provides the global overview over the soft gamma-ray sky, there is a growing need to perform deeper, more focused investigations of gamma-ray sources. In soft X-rays a comparable step was taken going from the Einstein and the EXOSAT satellites to the Chandra and XMM/Newton observatories. Technological advances in the past years in the domain of gamma-ray focusing using Laue diffraction have paved the way towards a new gamma-ray mission, providing major improvements regarding sensitivity and angular resolution. Such a future Gamma-Ray Imager will allow the study of particle acceleration processes and explosion physics in unprecedented detail, providing essential clues on the innermost nature of the most violent and most energetic processes in the Universe.

TU-FG-BRB-05: A 3 Dimensional Prompt Gamma Imaging System for Range Verification in Proton Radiotherapy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Draeger, E; Chen, H; Polf, J

2016-06-15

Purpose: To report on the initial developments of a clinical 3-dimensional (3D) prompt gamma (PG) imaging system for proton radiotherapy range verification. Methods: The new imaging system under development consists of a prototype Compton camera to measure PG emission during proton beam irradiation and software to reconstruct, display, and analyze 3D images of the PG emission. For initial test of the system, PGs were measured with a prototype CC during a 200 cGy dose delivery with clinical proton pencil beams (ranging from 100 MeV – 200 MeV) to a water phantom. Measurements were also carried out with the CC placedmore » 15 cm from the phantom for a full range 150 MeV pencil beam and with its range shifted by 2 mm. Reconstructed images of the PG emission were displayed by the clinical PG imaging software and compared to the dose distributions of the proton beams calculated by a commercial treatment planning system. Results: Measurements made with the new PG imaging system showed that a 3D image could be reconstructed from PGs measured during the delivery of 200 cGy of dose, and that shifts in the Bragg peak range of as little as 2 mm could be detected. Conclusion: Initial tests of a new PG imaging system show its potential to provide 3D imaging and range verification for proton radiotherapy. Based on these results, we have begun work to improve the system with the goal that images can be produced from delivery of as little as 20 cGy so that the system could be used for in-vivo proton beam range verification on a daily basis.« less

Gamma-Ray imaging for nuclear security and safety: Towards 3-D gamma-ray vision

NASA Astrophysics Data System (ADS)

Vetter, Kai; Barnowksi, Ross; Haefner, Andrew; Joshi, Tenzing H. Y.; Pavlovsky, Ryan; Quiter, Brian J.

2018-01-01

The development of portable gamma-ray imaging instruments in combination with the recent advances in sensor and related computer vision technologies enable unprecedented capabilities in the detection, localization, and mapping of radiological and nuclear materials in complex environments relevant for nuclear security and safety. Though multi-modal imaging has been established in medicine and biomedical imaging for some time, the potential of multi-modal data fusion for radiological localization and mapping problems in complex indoor and outdoor environments remains to be explored in detail. In contrast to the well-defined settings in medical or biological imaging associated with small field-of-view and well-constrained extension of the radiation field, in many radiological search and mapping scenarios, the radiation fields are not constrained and objects and sources are not necessarily known prior to the measurement. The ability to fuse radiological with contextual or scene data in three dimensions, in analog to radiological and functional imaging with anatomical fusion in medicine, provides new capabilities enhancing image clarity, context, quantitative estimates, and visualization of the data products. We have developed new means to register and fuse gamma-ray imaging with contextual data from portable or moving platforms. These developments enhance detection and mapping capabilities as well as provide unprecedented visualization of complex radiation fields, moving us one step closer to the realization of gamma-ray vision in three dimensions.

High-resolution single photon planar and spect imaging of brain and neck employing a system of two co-registered opposed gamma imaging heads

DOEpatents

Majewski, Stanislaw [Yorktown, VA; Proffitt, James [Newport News, VA

2011-12-06

A compact, mobile, dedicated SPECT brain imager that can be easily moved to the patient to provide in-situ imaging, especially when the patient cannot be moved to the Nuclear Medicine imaging center. As a result of the widespread availability of single photon labeled biomarkers, the SPECT brain imager can be used in many locations, including remote locations away from medical centers. The SPECT imager improves the detection of gamma emission from the patient's head and neck area with a large field of view. Two identical lightweight gamma imaging detector heads are mounted to a rotating gantry and precisely mechanically co-registered to each other at 180 degrees. A unique imaging algorithm combines the co-registered images from the detector heads and provides several SPECT tomographic reconstructions of the imaged object thereby improving the diagnostic quality especially in the case of imaging requiring higher spatial resolution and sensitivity at the same time.

Future Gamma-Ray Imaging of Solar Eruptive Events

NASA Technical Reports Server (NTRS)

Shih, Albert

2012-01-01

Solar eruptive events, the combination of large solar flares and coronal mass ejections (CMEs), accelerate ions to tens of Gev and electrons to hundreds of MeV. The energy in accelerated particles can be a significant fraction (up to tens of percent) of the released energy and is roughly equipartitioned between ions and electrons. Observations of the gamma-ray signatures produced by these particles interacting with the ambient solar atmosphere probes the distribution and composition of the accelerated population, as well as the atmospheric parameters and abundances of the atmosphere, ultimately revealing information about the underlying physics. Gamma-ray imaging provided by RHESSI showed that the interacting approx.20 MeV/nucleon ions are confined to flare magnetic loops rather than precipitating from a large CME-associated shock. Furthermore, RHESSI images show a surprising, significant spatial separation between the locations where accelerated ions and electrons are interacting, thus indicating a difference in acceleration or transport processes for the two types of particles. Future gamma-ray imaging observations, with higher sensitivity and greater angular resolution, can investigate more deeply the nature of ion acceleration. The technologies being proven on the Gamma-Ray Imager/Polarimeter for Solar flares (GRIPS), a NASA balloon instrument, are possible approaches for future instrumentation. We discuss the GRIPS instrument and the future of studying this aspect of solar eruptive events.

Gamma activity modulated by naming of ambiguous and unambiguous images: intracranial recording

PubMed Central

Cho-Hisamoto, Yoshimi; Kojima, Katsuaki; Brown, Erik C; Matsuzaki, Naoyuki; Asano, Eishi

2014-01-01

OBJECTIVE Humans sometimes need to recognize objects based on vague and ambiguous silhouettes. Recognition of such images may require an intuitive guess. We determined the spatial-temporal characteristics of intracranially-recorded gamma activity (at 50–120 Hz) augmented differentially by naming of ambiguous and unambiguous images. METHODS We studied ten patients who underwent epilepsy surgery. Ambiguous and unambiguous images were presented during extraoperative electrocorticography recording, and patients were instructed to overtly name the object as it is first perceived. RESULTS Both naming tasks were commonly associated with gamma-augmentation sequentially involving the occipital and occipital-temporal regions, bilaterally, within 200 ms after the onset of image presentation. Naming of ambiguous images elicited gamma-augmentation specifically involving portions of the inferior-frontal, orbitofrontal, and inferior-parietal regions at 400 ms and after. Unambiguous images were associated with more intense gamma-augmentation in portions of the occipital and occipital-temporal regions. CONCLUSIONS Frontal-parietal gamma-augmentation specific to ambiguous images may reflect the additional cortical processing involved in exerting intuitive guess. Occipital gamma-augmentation enhanced during naming of unambiguous images can be explained by visual processing of stimuli with richer detail. SIGNIFICANCE Our results support the theoretical model that guessing processes in visual domain occur following the accumulation of sensory evidence resulting from the bottom-up processing in the occipital-temporal visual pathways. PMID:24815577

An experimental assessment of the imaging quality of the low energy gamma-ray telescope ZEBRA

NASA Technical Reports Server (NTRS)

Butler, R. C.; Caroli, E.; Dicocco, G.; Natalucci, L.; Spada, G.; Spizzichino, A.; Stephen, J. B.; Carter, J. N.; Charalambous, P. M.; Dean, A. J.

1985-01-01

One gamma-ray detection plane of the ZEBRA telescope, consisting of nine position sensitive scintillation crystal bars designed to operate over the spectral range 0.2 to 10 MeV, has been constructed in the laboratory. A series of experimental images has been generated using a scaled down flight pattern mask in conjunction with a diverging gamma-ray beam. Point and extended sources have been imaged in order to assess quantitatively the performance of the system.

The Gamma-Ray Imager GRI

NASA Astrophysics Data System (ADS)

Wunderer, Cornelia B.; GRI Collaboration

2008-03-01

Observations of the gamma-ray sky reveal the most powerful sources and the most violent events in the Universe. While at lower wavebands the observed emission is generally dominated by thermal processes, the gamma-ray sky provides us with a view on the non-thermal Universe. Here particles are accelerated to extreme relativistic energies by mechanisms which are still poorly understood, and nuclear reactions are synthesizing the basic constituents of our world. Cosmic accelerators and cosmic explosions are major science themes that are addressed in the gamma-ray regime. ESA's INTEGRAL observatory currently provides the astronomical community with a unique tool to investigate the sky up to MeV energies and hundreds of sources, new classes of objects, extraordinary views of antimatter annihilation in our Galaxy, and fingerprints of recent nucleosynthesis processes have been discovered. NASA's GLAST mission will similarly take the next step in surveying the high-energy ( GeV) sky, and NuSTAR will pioneer focusing observations at hard X-ray energies (to 80 keV). There will be clearly a growing need to perform deeper, more focused investigations of gamma-ray sources in the 100-keV to MeV regime. Recent technological advances in the domain of gamma-ray focusing using Laue diffraction and multilayer-coated mirror techniques have paved the way towards a gamma-ray mission, providing major improvements compared to past missions regarding sensitivity and angular resolution. Such a future Gamma-Ray Imager will allow the study of particle acceleration processes and explosion physics in unprecedented detail, providing essential clues on the innermost nature of the most violent and most energetic processes in the Universe.

High spatial resolution X-ray and gamma ray imaging system using diffraction crystals

DOEpatents

Smither, Robert K [Hinsdale, IL

2011-05-17

A method and a device for high spatial resolution imaging of a plurality of sources of x-ray and gamma-ray radiation are provided. The device comprises a plurality of arrays, with each array comprising a plurality of elements comprising a first collimator, a diffracting crystal, a second collimator, and a detector.

Fermi gamma-ray imaging of a radio galaxy.

PubMed

Abdo, A A; Ackermann, M; Ajello, M; Atwood, W B; Baldini, L; Ballet, J; Barbiellini, G; Bastieri, D; Baughman, B M; Bechtol, K; Bellazzini, R; Berenji, B; Blandford, R D; Bloom, E D; Bonamente, E; Borgland, A W; Bregeon, J; Brez, A; Brigida, M; Bruel, P; Burnett, T H; Buson, S; Caliandro, G A; Cameron, R A; Caraveo, P A; Casandjian, J M; Cavazzuti, E; Cecchi, C; Celik, O; Chekhtman, A; Cheung, C C; Chiang, J; Ciprini, S; Claus, R; Cohen-Tanugi, J; Colafrancesco, S; Cominsky, L R; Conrad, J; Costamante, L; Cutini, S; Davis, D S; Dermer, C D; de Angelis, A; de Palma, F; Digel, S W; do Couto e Silva, E; Drell, P S; Dubois, R; Dumora, D; Farnier, C; Favuzzi, C; Fegan, S J; Finke, J; Focke, W B; Fortin, P; Fukazawa, Y; Funk, S; Fusco, P; Gargano, F; Gasparrini, D; Gehrels, N; Georganopoulos, M; Germani, S; Giebels, B; Giglietto, N; Giordano, F; Giroletti, M; Glanzman, T; Godfrey, G; Grenier, I A; Grove, J E; Guillemot, L; Guiriec, S; Hanabata, Y; Harding, A K; Hayashida, M; Hays, E; Hughes, R E; Jackson, M S; Jóhannesson, G; Johnson, A S; Johnson, T J; Johnson, W N; Kamae, T; Katagiri, H; Kataoka, J; Kawai, N; Kerr, M; Knödlseder, J; Kocian, M L; Kuss, M; Lande, J; Latronico, L; Lemoine-Goumard, M; Longo, F; Loparco, F; Lott, B; Lovellette, M N; Lubrano, P; Madejski, G M; Makeev, A; Mazziotta, M N; McConville, W; McEnery, J E; Meurer, C; Michelson, P F; Mitthumsiri, W; Mizuno, T; Moiseev, A A; Monte, C; Monzani, M E; Morselli, A; Moskalenko, I V; Murgia, S; Nolan, P L; Norris, J P; Nuss, E; Ohsugi, T; Omodei, N; Orlando, E; Ormes, J F; Paneque, D; Parent, D; Pelassa, V; Pepe, M; Pesce-Rollins, M; Piron, F; Porter, T A; Rainò, S; Rando, R; Razzano, M; Razzaque, S; Reimer, A; Reimer, O; Reposeur, T; Ritz, S; Rochester, L S; Rodriguez, A Y; Romani, R W; Roth, M; Ryde, F; Sadrozinski, H F-W; Sambruna, R; Sanchez, D; Sander, A; Saz Parkinson, P M; Scargle, J D; Sgrò, C; Siskind, E J; Smith, D A; Smith, P D; Spandre, G; Spinelli, P; Starck, J-L; Stawarz, Ł; Strickman, M S; Suson, D J; Tajima, H; Takahashi, H; Takahashi, T; Tanaka, T; Thayer, J B; Thayer, J G; Thompson, D J; Tibaldo, L; Torres, D F; Tosti, G; Tramacere, A; Uchiyama, Y; Usher, T L; Vasileiou, V; Vilchez, N; Vitale, V; Waite, A P; Wallace, E; Wang, P; Winer, B L; Wood, K S; Ylinen, T; Ziegler, M; Hardcastle, M J; Kazanas, D

2010-05-07

The Fermi Gamma-ray Space Telescope has detected the gamma-ray glow emanating from the giant radio lobes of the radio galaxy Centaurus A. The resolved gamma-ray image shows the lobes clearly separated from the central active source. In contrast to all other active galaxies detected so far in high-energy gamma-rays, the lobe flux constitutes a considerable portion (greater than one-half) of the total source emission. The gamma-ray emission from the lobes is interpreted as inverse Compton-scattered relic radiation from the cosmic microwave background, with additional contribution at higher energies from the infrared-to-optical extragalactic background light. These measurements provide gamma-ray constraints on the magnetic field and particle energy content in radio galaxy lobes, as well as a promising method to probe the cosmic relic photon fields.

A Monte Carlo simulation study for the gamma-ray/neutron dual-particle imager using rotational modulation collimator (RMC).

PubMed

Kim, Hyun Suk; Choi, Hong Yeop; Lee, Gyemin; Ye, Sung-Joon; Smith, Martin B; Kim, Geehyun

2018-03-01

The aim of this work is to develop a gamma-ray/neutron dual-particle imager, based on rotational modulation collimators (RMCs) and pulse shape discrimination (PSD)-capable scintillators, for possible applications for radioactivity monitoring as well as nuclear security and safeguards. A Monte Carlo simulation study was performed to design an RMC system for the dual-particle imaging, and modulation patterns were obtained for gamma-ray and neutron sources in various configurations. We applied an image reconstruction algorithm utilizing the maximum-likelihood expectation-maximization method based on the analytical modeling of source-detector configurations, to the Monte Carlo simulation results. Both gamma-ray and neutron source distributions were reconstructed and evaluated in terms of signal-to-noise ratio, showing the viability of developing an RMC-based gamma-ray/neutron dual-particle imager using PSD-capable scintillators.

Online gamma-camera imaging of 103Pd seeds (OGIPS) for permanent breast seed implantation

NASA Astrophysics Data System (ADS)

Ravi, Ananth; Caldwell, Curtis B.; Keller, Brian M.; Reznik, Alla; Pignol, Jean-Philippe

2007-09-01

Permanent brachytherapy seed implantation is being investigated as a mode of accelerated partial breast irradiation for early stage breast cancer patients. Currently, the seeds are poorly visualized during the procedure making it difficult to perform a real-time correction of the implantation if required. The objective was to determine if a customized gamma-camera can accurately localize the seeds during implantation. Monte Carlo simulations of a CZT based gamma-camera were used to assess whether images of suitable quality could be derived by detecting the 21 keV photons emitted from 74 MBq 103Pd brachytherapy seeds. A hexagonal parallel hole collimator with a hole length of 38 mm, hole diameter of 1.2 mm and 0.2 mm septa, was modeled. The design of the gamma-camera was evaluated on a realistic model of the breast and three layers of the seed distribution (55 seeds) based on a pre-implantation CT treatment plan. The Monte Carlo simulations showed that the gamma-camera was able to localize the seeds with a maximum error of 2.0 mm, using only two views and 20 s of imaging. A gamma-camera can potentially be used as an intra-procedural image guidance system for quality assurance for permanent breast seed implantation.

High-resolution imaging gamma-ray spectroscopy with externally segmented germanium detectors

NASA Technical Reports Server (NTRS)

Callas, J. L.; Mahoney, W. A.; Varnell, L. S.; Wheaton, W. A.

1993-01-01

Externally segmented germanium detectors promise a breakthrough in gamma-ray imaging capabilities while retaining the superb energy resolution of germanium spectrometers. An angular resolution of 0.2 deg becomes practical by combining position-sensitive germanium detectors having a segment thickness of a few millimeters with a one-dimensional coded aperture located about a meter from the detectors. Correspondingly higher angular resolutions are possible with larger separations between the detectors and the coded aperture. Two-dimensional images can be obtained by rotating the instrument. Although the basic concept is similar to optical or X-ray coded-aperture imaging techniques, several complicating effects arise because of the penetrating nature of gamma rays. The complications include partial transmission through the coded aperture elements, Compton scattering in the germanium detectors, and high background count rates. Extensive electron-photon Monte Carlo modeling of a realistic detector/coded-aperture/collimator system has been performed. Results show that these complicating effects can be characterized and accounted for with no significant loss in instrument sensitivity.

Motion estimation accuracy for visible-light/gamma-ray imaging fusion for portable portal monitoring

NASA Astrophysics Data System (ADS)

Karnowski, Thomas P.; Cunningham, Mark F.; Goddard, James S.; Cheriyadat, Anil M.; Hornback, Donald E.; Fabris, Lorenzo; Kerekes, Ryan A.; Ziock, Klaus-Peter; Gee, Timothy F.

2010-01-01

The use of radiation sensors as portal monitors is increasing due to heightened concerns over the smuggling of fissile material. Portable systems that can detect significant quantities of fissile material that might be present in vehicular traffic are of particular interest. We have constructed a prototype, rapid-deployment portal gamma-ray imaging portal monitor that uses machine vision and gamma-ray imaging to monitor multiple lanes of traffic. Vehicles are detected and tracked by using point detection and optical flow methods as implemented in the OpenCV software library. Points are clustered together but imperfections in the detected points and tracks cause errors in the accuracy of the vehicle position estimates. The resulting errors cause a "blurring" effect in the gamma image of the vehicle. To minimize these errors, we have compared a variety of motion estimation techniques including an estimate using the median of the clustered points, a "best-track" filtering algorithm, and a constant velocity motion estimation model. The accuracy of these methods are contrasted and compared to a manually verified ground-truth measurement by quantifying the rootmean- square differences in the times the vehicles cross the gamma-ray image pixel boundaries compared with a groundtruth manual measurement.

Quantitative criteria for assessment of gamma-ray imager performance

NASA Astrophysics Data System (ADS)

Gottesman, Steve; Keller, Kristi; Malik, Hans

2015-08-01

In recent years gamma ray imagers such as the GammaCamTM and Polaris have demonstrated good imaging performance in the field. Imager performance is often summarized as "resolution", either angular, or spatial at some distance from the imager, however the definition of resolution is not always related to the ability to image an object. It is difficult to quantitatively compare imagers without a common definition of image quality. This paper examines three categories of definition: point source; line source; and area source. It discusses the details of those definitions and which ones are more relevant for different situations. Metrics such as Full Width Half Maximum (FWHM), variations on the Rayleigh criterion, and some analogous to National Imagery Interpretability Rating Scale (NIIRS) are discussed. The performance against these metrics is evaluated for a high resolution coded aperture imager modeled using Monte Carlo N-Particle (MCNP), and for a medium resolution imager measured in the lab.

GRI: the gamma-ray imager mission

NASA Astrophysics Data System (ADS)

Knödlseder, Jürgen

2006-06-01

Observations of the gamma-ray sky reveal the most powerful sources and the most violent events in the Universe. While at lower wavebands the observed emission is generally dominated by thermal processes, the gamma-ray sky provides us with a view on the non-thermal Universe. Here particles are accelerated to extreme relativistic energies by mechanisms which are still poorly understood, and nuclear reactions are synthesizing the basic constituents of our world. Cosmic accelerators and cosmic explosions are the major science themes that are addressed in the gamma-ray regime. With the INTEGRAL observatory, ESA has provided a unique tool to the astronomical community revealing hundreds of sources, new classes of objects, extraordinary views of antimatter annihilation in our Galaxy, and fingerprints of recent nucleosynthesis processes. While INTEGRAL provides the global overview over the soft gamma-ray sky, there is a growing need to perform deeper, more focused investigations of gamma-ray sources. In soft X-rays a comparable step was taken going from the Einstein and the EXOSAT satellites to the Chandra and XMM/Newton observatories. Technological advances in the past years in the domain of gamma-ray focusing using Laue diffraction and multilayer-coated mirror techniques hav paved the way towards a gamma-ray mission, providing major improvements compared to past missions regarding sensitivity and angular resolution. Such a future Gamma-Ray Imager will allow to study particle acceleration processes and explosion physics in unprecedented detail, providing essential clues on the innermost nature of the most violent and most energetic processes in the Universe.

Systems for increasing the sensitivity of gamma-ray imagers

DOEpatents

Mihailescu, Lucian; Vetter, Kai M.; Chivers, Daniel H.

2012-12-11

Systems that increase the position resolution and granularity of double sided segmented semiconductor detectors are provided. These systems increase the imaging resolution capability of such detectors, either used as Compton cameras, or as position sensitive radiation detectors in imagers such as SPECT, PET, coded apertures, multi-pinhole imagers, or other spatial or temporal modulated imagers.

The Advanced Gamma-ray Imaging System (AGIS) - Camera Electronics Development

NASA Astrophysics Data System (ADS)

Tajima, Hiroyasu; Bechtol, K.; Buehler, R.; Buckley, J.; Byrum, K.; Drake, G.; Falcone, A.; Funk, S.; Hanna, D.; Horan, D.; Humensky, B.; Karlsson, N.; Kieda, D.; Konopelko, A.; Krawczynski, H.; Krennrich, F.; Mukherjee, R.; Ong, R.; Otte, N.; Quinn, J.; Schroedter, M.; Swordy, S.; Wagner, R.; Wakely, S.; Weinstein, A.; Williams, D.; Camera Working Group; AGIS Collaboration

2010-03-01

AGIS, a next-generation imaging atmospheric Cherenkov telescope (IACT) array, aims to achieve a sensitivity level of about one milliCrab for gamma-ray observations in the energy band of 50 GeV to 100 TeV. Achieving this level of performance will require on the order of 50 telescopes with perhaps as many as 1M total electronics channels. The larger scale of AGIS requires a very different approach from the currently operating IACTs, with lower-cost and lower-power electronics incorporated into camera modules designed for high reliability and easy maintenance. Here we present the concept and development status of the AGIS camera electronics.

Establishment of Imaging Spectroscopy of Nuclear Gamma-Rays based on Geometrical Optics

PubMed Central

Tanimori, Toru; Mizumura, Yoshitaka; Takada, Atsushi; Miyamoto, Shohei; Takemura, Taito; Kishimoto, Tetsuro; Komura, Shotaro; Kubo, Hidetoshi; Kurosawa, Shunsuke; Matsuoka, Yoshihiro; Miuchi, Kentaro; Mizumoto, Tetsuya; Nakamasu, Yuma; Nakamura, Kiseki; Parker, Joseph D.; Sawano, Tatsuya; Sonoda, Shinya; Tomono, Dai; Yoshikawa, Kei

2017-01-01

Since the discovery of nuclear gamma-rays, its imaging has been limited to pseudo imaging, such as Compton Camera (CC) and coded mask. Pseudo imaging does not keep physical information (intensity, or brightness in Optics) along a ray, and thus is capable of no more than qualitative imaging of bright objects. To attain quantitative imaging, cameras that realize geometrical optics is essential, which would be, for nuclear MeV gammas, only possible via complete reconstruction of the Compton process. Recently we have revealed that “Electron Tracking Compton Camera” (ETCC) provides a well-defined Point Spread Function (PSF). The information of an incoming gamma is kept along a ray with the PSF and that is equivalent to geometrical optics. Here we present an imaging-spectroscopic measurement with the ETCC. Our results highlight the intrinsic difficulty with CCs in performing accurate imaging, and show that the ETCC surmounts this problem. The imaging capability also helps the ETCC suppress the noise level dramatically by ~3 orders of magnitude without a shielding structure. Furthermore, full reconstruction of Compton process with the ETCC provides spectra free of Compton edges. These results mark the first proper imaging of nuclear gammas based on the genuine geometrical optics. PMID:28155870

Establishment of Imaging Spectroscopy of Nuclear Gamma-Rays based on Geometrical Optics.

PubMed

Tanimori, Toru; Mizumura, Yoshitaka; Takada, Atsushi; Miyamoto, Shohei; Takemura, Taito; Kishimoto, Tetsuro; Komura, Shotaro; Kubo, Hidetoshi; Kurosawa, Shunsuke; Matsuoka, Yoshihiro; Miuchi, Kentaro; Mizumoto, Tetsuya; Nakamasu, Yuma; Nakamura, Kiseki; Parker, Joseph D; Sawano, Tatsuya; Sonoda, Shinya; Tomono, Dai; Yoshikawa, Kei

2017-02-03

Since the discovery of nuclear gamma-rays, its imaging has been limited to pseudo imaging, such as Compton Camera (CC) and coded mask. Pseudo imaging does not keep physical information (intensity, or brightness in Optics) along a ray, and thus is capable of no more than qualitative imaging of bright objects. To attain quantitative imaging, cameras that realize geometrical optics is essential, which would be, for nuclear MeV gammas, only possible via complete reconstruction of the Compton process. Recently we have revealed that "Electron Tracking Compton Camera" (ETCC) provides a well-defined Point Spread Function (PSF). The information of an incoming gamma is kept along a ray with the PSF and that is equivalent to geometrical optics. Here we present an imaging-spectroscopic measurement with the ETCC. Our results highlight the intrinsic difficulty with CCs in performing accurate imaging, and show that the ETCC surmounts this problem. The imaging capability also helps the ETCC suppress the noise level dramatically by ~3 orders of magnitude without a shielding structure. Furthermore, full reconstruction of Compton process with the ETCC provides spectra free of Compton edges. These results mark the first proper imaging of nuclear gammas based on the genuine geometrical optics.

Dual-modality imaging with a ultrasound-gamma device for oncology

NASA Astrophysics Data System (ADS)

Polito, C.; Pellegrini, R.; Cinti, M. N.; De Vincentis, G.; Lo Meo, S.; Fabbri, A.; Bennati, P.; Cencelli, V. Orsolini; Pani, R.

2018-06-01

Recently, dual-modality systems have been developed, aimed to correlate anatomical and functional information, improving disease localization and helping oncological or surgical treatments. Moreover, due to the growing interest in handheld detectors for preclinical trials or small animal imaging, in this work a new dual modality integrated device, based on a Ultrasounds probe and a small Field of View Single Photon Emission gamma camera, is proposed.

Neutron and Gamma Imaging for National Security Applications

NASA Astrophysics Data System (ADS)

Hornback, Donald

2017-09-01

The Department of Energy, National Nuclear Security Administration (NNSA), Office of Defense Nuclear Nonproliferation Research and Development (DNN R&D/NA-22) possesses, in part, the mission to develop technologies in support of nuclear security efforts in coordination with other U.S. government entities, such as the Department of Defense and the Department of Homeland Security. DNN R&D has long supported research in nuclear detection at national labs, universities, and through the small business innovation research (SBIR) program. Research topics supported include advanced detector materials and electronics, detection algorithm development, and advanced gamma/neutron detection systems. Neutron and gamma imaging, defined as the directional detection of radiation as opposed to radiography, provides advanced detection capabilities for the NNSA mission in areas of emergency response, international safeguards, and nuclear arms control treaty monitoring and verification. A technical and programmatic overview of efforts in this field of research will be summarized.

First Flight of the Gamma-Ray Imager Polarimeter for Solar Flares (GRIPS) Instrument

NASA Technical Reports Server (NTRS)

Duncan, Nicole; Saint-Hilaire, P.; Shih, A. Y.; Hurford, G. J.; Bain, H. M.; Amman, M.; Mochizuki, A. B.; Hoberman, J.; Olson, J.; Maruca, B. A.;

Slit-Slat Collimator Equipped Gamma Camera for Whole-Mouse SPECT-CT Imaging

NASA Astrophysics Data System (ADS)

Cao, Liji; Peter, Jörg

2012-06-01

A slit-slat collimator is developed for a gamma camera intended for small-animal imaging (mice). The tungsten housing of a roof-shaped collimator forms a slit opening, and the slats are made of lead foils separated by sparse polyurethane material. Alignment of the collimator with the camera's pixelated crystal is performed by adjusting a micrometer screw while monitoring a Co-57 point source for maximum signal intensity. For SPECT, the collimator forms a cylindrical field-of-view enabling whole mouse imaging with transaxial magnification and constant on-axis sensitivity over the entire axial direction. As the gamma camera is part of a multimodal imaging system incorporating also x-ray CT, five parameters corresponding to the geometric displacements of the collimator as well as to the mechanical co-alignment between the gamma camera and the CT subsystem are estimated by means of bimodal calibration sources. To illustrate the performance of the slit-slat collimator and to compare its performance to a single pinhole collimator, a Derenzo phantom study is performed. Transaxial resolution along the entire long axis is comparable to a pinhole collimator of same pinhole diameter. Axial resolution of the slit-slat collimator is comparable to that of a parallel beam collimator. Additionally, data from an in-vivo mouse study are presented.

Development of an all-in-one gamma camera/CCD system for safeguard verification

NASA Astrophysics Data System (ADS)

Kim, Hyun-Il; An, Su Jung; Chung, Yong Hyun; Kwak, Sung-Woo

2014-12-01

For the purpose of monitoring and verifying efforts at safeguarding radioactive materials in various fields, a new all-in-one gamma camera/charged coupled device (CCD) system was developed. This combined system consists of a gamma camera, which gathers energy and position information on gamma-ray sources, and a CCD camera, which identifies the specific location in a monitored area. Therefore, 2-D image information and quantitative information regarding gamma-ray sources can be obtained using fused images. A gamma camera consists of a diverging collimator, a 22 × 22 array CsI(Na) pixelated scintillation crystal with a pixel size of 2 × 2 × 6 mm3 and Hamamatsu H8500 position-sensitive photomultiplier tube (PSPMT). The Basler scA640-70gc CCD camera, which delivers 70 frames per second at video graphics array (VGA) resolution, was employed. Performance testing was performed using a Co-57 point source 30 cm from the detector. The measured spatial resolution and sensitivity were 4.77 mm full width at half maximum (FWHM) and 7.78 cps/MBq, respectively. The energy resolution was 18% at 122 keV. These results demonstrate that the combined system has considerable potential for radiation monitoring.

High-Resolution Gamma-Ray Imaging Measurements Using Externally Segmented Germanium Detectors

NASA Technical Reports Server (NTRS)

Callas, J.; Mahoney, W.; Skelton, R.; Varnell, L.; Wheaton, W.

1994-01-01

Fully two-dimensional gamma-ray imaging with simultaneous high-resolution spectroscopy has been demonstrated using an externally segmented germanium sensor. The system employs a single high-purity coaxial detector with its outer electrode segmented into 5 distinct charge collection regions and a lead coded aperture with a uniformly redundant array (URA) pattern. A series of one-dimensional responses was collected around 511 keV while the system was rotated in steps through 180 degrees. A non-negative, linear least-squares algorithm was then employed to reconstruct a 2-dimensional image. Corrections for multiple scattering in the detector, and the finite distance of source and detector are made in the reconstruction process.

First flight of the Gamma-Ray Imager/Polarimeter for Solar flares (GRIPS) instrument

NASA Astrophysics Data System (ADS)

Duncan, Nicole; Saint-Hilaire, P.; Shih, A. Y.; Hurford, G. J.; Bain, H. M.; Amman, M.; Mochizuki, B. A.; Hoberman, J.; Olson, J.; Maruca, B. A.; Godbole, N. M.; Smith, D. M.; Sample, J.; Kelley, N. A.; Zoglauer, A.; Caspi, A.; Kaufmann, P.; Boggs, S.; Lin, R. P.

2016-07-01

The Gamma-Ray Imager/Polarimeter for Solar flares (GRIPS) instrument is a balloon-borne telescope designed to study solar- are particle acceleration and transport. We describe GRIPS's first Antarctic long-duration flight in January 2016 and report preliminary calibration and science results. Electron and ion dynamics, particle abundances and the ambient plasma conditions in solar flares can be understood by examining hard X-ray (HXR) and gamma-ray emission (20 keV to 10 MeV). Enhanced imaging, spectroscopy and polarimetry of are emissions in this energy range are needed to study particle acceleration and transport questions. The GRIPS instrument is specifically designed to answer questions including: What causes the spatial separation between energetic electrons producing hard X-rays and energetic ions producing gamma-ray lines? How anisotropic are the relativistic electrons, and why can they dominate in the corona? How do the compositions of accelerated and ambient material vary with space and time, and why? GRIPS's key technological improvements over the current solar state of the art at HXR/gamma-ray energies, the Reuven Ramaty High Energy Solar Spectroscopic Imager (RHESSI), include 3D position-sensitive germanium detectors (3D-GeDs) and a single-grid modulation collimator, the multi-pitch rotating modulator (MPRM). The 3D-GeDs have spectral FWHM resolution of a few hundred keV and spatial resolution <1 mm3. For photons that Compton scatter, usually > 150 keV, the energy deposition sites can be tracked, providing polarization measurements as well as enhanced background reduction through Compton imaging. Each of GRIPS's detectors has 298 electrode strips read out with ASIC/FPGA electronics. In GRIPS's energy range, indirect imaging methods provide higher resolution than focusing optics or Compton imaging techniques. The MPRM gridimaging system has a single-grid design which provides twice the throughput of a bi-grid imaging system like RHESSI. The grid is

Prompt gamma ray imaging for verification of proton boron fusion therapy: A Monte Carlo study.

PubMed

Shin, Han-Back; Yoon, Do-Kun; Jung, Joo-Young; Kim, Moo-Sub; Suh, Tae Suk

2016-10-01

The purpose of this study was to verify acquisition feasibility of a single photon emission computed tomography image using prompt gamma rays for proton boron fusion therapy (PBFT) and to confirm an enhanced therapeutic effect of PBFT by comparison with conventional proton therapy without use of boron. Monte Carlo simulation was performed to acquire reconstructed image during PBFT. We acquired percentage depth dose (PDD) of the proton beams in a water phantom, energy spectrum of the prompt gamma rays, and tomographic images, including the boron uptake region (BUR; target). The prompt gamma ray image was reconstructed using maximum likelihood expectation maximisation (MLEM) with 64 projection raw data. To verify the reconstructed image, both an image profile and contrast analysis according to the iteration number were conducted. In addition, the physical distance between two BURs in the region of interest of each BUR was measured. The PDD of the proton beam from the water phantom including the BURs shows more efficient than that of conventional proton therapy on tumour region. A 719keV prompt gamma ray peak was clearly observed in the prompt gamma ray energy spectrum. The prompt gamma ray image was reconstructed successfully using 64 projections. Different image profiles including two BURs were acquired from the reconstructed image according to the iteration number. We confirmed successful acquisition of a prompt gamma ray image during PBFT. In addition, the quantitative image analysis results showed relatively good performance for further study. Copyright © 2016 Associazione Italiana di Fisica Medica. Published by Elsevier Ltd. All rights reserved.

Novel Applications of Rapid Prototyping in Gamma-ray and X-ray Imaging

PubMed Central

Miller, Brian W.; Moore, Jared W.; Gehm, Michael E.; Furenlid, Lars R.; Barrett, Harrison H.

2010-01-01

Advances in 3D rapid-prototyping printers, 3D modeling software, and casting techniques allow for the fabrication of cost-effective, custom components in gamma-ray and x-ray imaging systems. Applications extend to new fabrication methods for custom collimators, pinholes, calibration and resolution phantoms, mounting and shielding components, and imaging apertures. Details of the fabrication process for these components are presented, specifically the 3D printing process, cold casting with a tungsten epoxy, and lost-wax casting in platinum. PMID:22984341

GPU-based prompt gamma ray imaging from boron neutron capture therapy.

PubMed

Yoon, Do-Kun; Jung, Joo-Young; Jo Hong, Key; Sil Lee, Keum; Suk Suh, Tae

2015-01-01

The purpose of this research is to perform the fast reconstruction of a prompt gamma ray image using a graphics processing unit (GPU) computation from boron neutron capture therapy (BNCT) simulations. To evaluate the accuracy of the reconstructed image, a phantom including four boron uptake regions (BURs) was used in the simulation. After the Monte Carlo simulation of the BNCT, the modified ordered subset expectation maximization reconstruction algorithm using the GPU computation was used to reconstruct the images with fewer projections. The computation times for image reconstruction were compared between the GPU and the central processing unit (CPU). Also, the accuracy of the reconstructed image was evaluated by a receiver operating characteristic (ROC) curve analysis. The image reconstruction time using the GPU was 196 times faster than the conventional reconstruction time using the CPU. For the four BURs, the area under curve values from the ROC curve were 0.6726 (A-region), 0.6890 (B-region), 0.7384 (C-region), and 0.8009 (D-region). The tomographic image using the prompt gamma ray event from the BNCT simulation was acquired using the GPU computation in order to perform a fast reconstruction during treatment. The authors verified the feasibility of the prompt gamma ray image reconstruction using the GPU computation for BNCT simulations.

Primary gamma ray selection in a hybrid timing/imaging Cherenkov array

NASA Astrophysics Data System (ADS)

Postnikov, E. B.; Grinyuk, A. A.; Kuzmichev, L. A.; Sveshnikova, L. G.

2017-06-01

This work is a methodical study on hybrid reconstruction techniques for hybrid imaging/timing Cherenkov observations. This type of hybrid array is to be realized at the gamma-observatory TAIGA intended for very high energy gamma-ray astronomy (> 30 TeV). It aims at combining the cost-effective timing-array technique with imaging telescopes. Hybrid operation of both of these techniques can lead to a relatively cheap way of development of a large area array. The joint approach of gamma event selection was investigated on both types of simulated data: the image parameters from the telescopes, and the shower parameters reconstructed from the timing array. The optimal set of imaging parameters and shower parameters to be combined is revealed. The cosmic ray background suppression factor depending on distance and energy is calculated. The optimal selection technique leads to cosmic ray background suppression of about 2 orders of magnitude on distances up to 450 m for energies greater than 50 TeV.

SU-E-E-06: Teaching About the Gamma Camera and Ultrasound Imaging

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lowe, M; Spiro, A; Vogel, R

Purpose: Instructional modules on applications of physics in medicine are being developed. The target audience consists of students who have had an introductory undergraduate physics course. This presentation will concentrate on an active learning approach to teach the principles of the gamma camera. There will also be a description of an apparatus to teach ultrasound imaging. Methods: Since a real gamma camera is not feasible in the undergraduate classroom, we have developed two types of optical apparatus that teach the main principles. To understand the collimator, LEDS mimic gamma emitters in the body, and the photons pass through an arraymore » of tubes. The distance, spacing, diameter, and length of the tubes can be varied to understand the effect upon the resolution of the image. To determine the positions of the gamma emitters, a second apparatus uses a movable green laser, fluorescent plastic in lieu of the scintillation crystal, acrylic rods that mimic the PMTs, and a photodetector to measure the intensity. The position of the laser is calculated with a centroid algorithm.To teach the principles of ultrasound imaging, we are using the sound head and pulser box of an educational product, variable gain amplifier, rotation table, digital oscilloscope, Matlab software, and phantoms. Results: Gamma camera curriculum materials have been implemented in the classroom at Loyola in 2014 and 2015. Written work shows good knowledge retention and a more complete understanding of the material. Preliminary ultrasound imaging materials were run in 2015. Conclusion: Active learning methods add another dimension to descriptions in textbooks and are effective in keeping the students engaged during class time. The teaching apparatus for the gamma camera and ultrasound imaging can be expanded to include more cases, and could potentially improve students’ understanding of artifacts and distortions in the images.« less

Gamma-Ray Imager With High Spatial And Spectral Resolution

NASA Technical Reports Server (NTRS)

Callas, John L.; Varnell, Larry S.; Wheaton, William A.; Mahoney, William A.

1996-01-01

Gamma-ray instrument developed to enable both two-dimensional imaging at relatively high spatial resolution and spectroscopy at fractional-photon-energy resolution of about 10 to the negative 3rd power in photon-energy range from 10 keV to greater than 10 MeV. In its spectroscopic aspect, instrument enables identification of both narrow and weak gamma-ray spectral peaks.

SU-C-201-03: Coded Aperture Gamma-Ray Imaging Using Pixelated Semiconductor Detectors

DOE Office of Scientific and Technical Information (OSTI.GOV)

Joshi, S; Kaye, W; Jaworski, J

2015-06-15

Purpose: Improved localization of gamma-ray emissions from radiotracers is essential to the progress of nuclear medicine. Polaris is a portable, room-temperature operated gamma-ray imaging spectrometer composed of two 3×3 arrays of thick CdZnTe (CZT) detectors, which detect gammas between 30keV and 3MeV with energy resolution of <1% FWHM at 662keV. Compton imaging is used to map out source distributions in 4-pi space; however, is only effective above 300keV where Compton scatter is dominant. This work extends imaging to photoelectric energies (<300keV) using coded aperture imaging (CAI), which is essential for localization of Tc-99m (140keV). Methods: CAI, similar to the pinholemore » camera, relies on an attenuating mask, with open/closed elements, placed between the source and position-sensitive detectors. Partial attenuation of the source results in a “shadow” or count distribution that closely matches a portion of the mask pattern. Ideally, each source direction corresponds to a unique count distribution. Using backprojection reconstruction, the source direction is determined within the field of view. The knowledge of 3D position of interaction results in improved image quality. Results: Using a single array of detectors, a coded aperture mask, and multiple Co-57 (122keV) point sources, image reconstruction is performed in real-time, on an event-by-event basis, resulting in images with an angular resolution of ∼6 degrees. Although material nonuniformities contribute to image degradation, the superposition of images from individual detectors results in improved SNR. CAI was integrated with Compton imaging for a seamless transition between energy regimes. Conclusion: For the first time, CAI has been applied to thick, 3D position sensitive CZT detectors. Real-time, combined CAI and Compton imaging is performed using two 3×3 detector arrays, resulting in a source distribution in space. This system has been commercialized by H3D, Inc. and is being acquired

COMPUTER ANALYSIS OF PLANAR GAMMA CAMERA IMAGES

EPA Science Inventory

COMPUTER ANALYSIS OF PLANAR GAMMA CAMERA IMAGES

T Martonen1 and J Schroeter2

1Experimental Toxicology Division, National Health and Environmental Effects Research Laboratory, U.S. EPA, Research Triangle Park, NC 27711 USA and 2Curriculum in Toxicology, Unive...

GPU-based prompt gamma ray imaging from boron neutron capture therapy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yoon, Do-Kun; Jung, Joo-Young; Suk Suh, Tae, E-mail: suhsanta@catholic.ac.kr

Purpose: The purpose of this research is to perform the fast reconstruction of a prompt gamma ray image using a graphics processing unit (GPU) computation from boron neutron capture therapy (BNCT) simulations. Methods: To evaluate the accuracy of the reconstructed image, a phantom including four boron uptake regions (BURs) was used in the simulation. After the Monte Carlo simulation of the BNCT, the modified ordered subset expectation maximization reconstruction algorithm using the GPU computation was used to reconstruct the images with fewer projections. The computation times for image reconstruction were compared between the GPU and the central processing unit (CPU).more » Also, the accuracy of the reconstructed image was evaluated by a receiver operating characteristic (ROC) curve analysis. Results: The image reconstruction time using the GPU was 196 times faster than the conventional reconstruction time using the CPU. For the four BURs, the area under curve values from the ROC curve were 0.6726 (A-region), 0.6890 (B-region), 0.7384 (C-region), and 0.8009 (D-region). Conclusions: The tomographic image using the prompt gamma ray event from the BNCT simulation was acquired using the GPU computation in order to perform a fast reconstruction during treatment. The authors verified the feasibility of the prompt gamma ray image reconstruction using the GPU computation for BNCT simulations.« less

An evolution of technologies and applications of gamma imagers in the nuclear cycle industry

DOE Office of Scientific and Technical Information (OSTI.GOV)

Khalil, R. A.; Carrel, F.; Menaa, N.

The tracking of radiation contamination and distribution has become a high priority in the nuclear cycle industry in order to respect the ALARA principle which is a main challenge during decontamination and dismantling activities. To support this need, AREVA/CANBERRA and CEA LIST have been actively carrying out research and development on a gamma-radiation imager. In this paper we will present the new generation of gamma camera, called GAMPIX. This system is based on the Timepix chip, hybridized with a CdTe substrate. A coded mask could be used in order to increase the sensitivity of the camera. Moreover, due to themore » USB connection with a standard computer, this gamma camera is immediately operational and user-friendly. The final system is a very compact gamma camera (global weight is less than 1 kg without any shielding) which could be used as a hand-held device for radioprotection purposes. In this article, we present the main characteristics of this new generation of gamma camera and we expose experimental results obtained during in situ measurements. Even though we present preliminary results the final product is under industrialization phase to address various applications specifications. (authors)« less

Prompt gamma imaging of proton pencil beams at clinical dose rate

NASA Astrophysics Data System (ADS)

Perali, I.; Celani, A.; Bombelli, L.; Fiorini, C.; Camera, F.; Clementel, E.; Henrotin, S.; Janssens, G.; Prieels, D.; Roellinghoff, F.; Smeets, J.; Stichelbaut, F.; Vander Stappen, F.

2014-10-01

In this work, we present experimental results of a prompt gamma camera for real-time proton beam range verification. The detection system features a pixelated Cerium doped lutetium based scintillation crystal, coupled to Silicon PhotoMultiplier arrays, read out by dedicated electronics. The prompt gamma camera uses a knife-edge slit collimator to produce a 1D projection of the beam path in the target on the scintillation detector. We designed the detector to provide high counting statistics and high photo-detection efficiency for prompt gamma rays of several MeV. The slit design favours the counting statistics and could be advantageous in terms of simplicity, reduced cost and limited footprint. We present the description of the realized gamma camera, as well as the results of the characterization of the camera itself in terms of imaging performance. We also present the results of experiments in which a polymethyl methacrylate phantom was irradiated with proton pencil beams in a proton therapy center. A tungsten slit collimator was used and prompt gamma rays were acquired in the 3-6 MeV energy range. The acquisitions were performed with the beam operated at 100 MeV, 160 MeV and 230 MeV, with beam currents at the nozzle exit of several nA. Measured prompt gamma profiles are consistent with the simulations and we reached a precision (2σ) in shift retrieval of 4 mm with 0.5 × 108, 1.4 × 108 and 3.4 × 108 protons at 100, 160 and 230 MeV, respectively. We conclude that the acquisition of prompt gamma profiles for in vivo range verification of proton beam with the developed gamma camera and a slit collimator is feasible in clinical conditions. The compact design of the camera allows its integration in a proton therapy treatment room and further studies will be undertaken to validate the use of this detection system during treatment of real patients.

Solar X-Ray and Gamma-Ray Imaging Spectroscopy

NASA Astrophysics Data System (ADS)

Dennis, B. R.; Christe, S. D.; Shih, A. Y.; Holman, G. D.; Emslie, A. G.; Caspi, A.

2018-02-01

X-ray and gamma-ray Sun observations from a lunar-based observatory would provide unique information on solar atmosphere thermal and nonthermal processes. EUV and energetic neutral atom imaging spectroscopy would augment the scientific value.

The Gamma-Ray Imager/Polarimeter for Solar Flares (GRIPS)

NASA Technical Reports Server (NTRS)

Shih, Albert Y.; Lin, Robert P.; Hurford, Gordon J.; Duncan, Nicole A.; Saint-Hilaire, Pascal; Bain, Hazel M.; Boggs, Steven E.; Zoglauer, Andreas C.; Smith, David M.; Tajima, Hiroyasu;

3D printing in X-ray and Gamma-Ray Imaging: A novel method for fabricating high-density imaging apertures☆

PubMed Central

Miller, Brian W.; Moore, Jared W.; Barrett, Harrison H.; Fryé, Teresa; Adler, Steven; Sery, Joe; Furenlid, Lars R.

2011-01-01

Advances in 3D rapid-prototyping printers, 3D modeling software, and casting techniques allow for cost-effective fabrication of custom components in gamma-ray and X-ray imaging systems. Applications extend to new fabrication methods for custom collimators, pinholes, calibration and resolution phantoms, mounting and shielding components, and imaging apertures. Details of the fabrication process for these components, specifically the 3D printing process, cold casting with a tungsten epoxy, and lost-wax casting in platinum are presented. PMID:22199414

Rotational-translational fourier imaging system requiring only one grid pair

NASA Technical Reports Server (NTRS)

Campbell, Jonathan W. (Inventor)

2006-01-01

The sky contains many active sources that emit X-rays, gamma rays, and neutrons. Unfortunately hard X-rays, gamma rays, and neutrons cannot be imaged by conventional optics. This obstacle led to the development of Fourier imaging systems. In early approaches, multiple grid pairs were necessary in order to create rudimentary Fourier imaging systems. At least one set of grid pairs was required to provide multiple real components of a Fourier derived image, and another set was required to provide multiple imaginary components of the image. It has long been recognized that the expense associated with the physical production of the numerous grid pairs required for Fourier imaging was a drawback. Herein one grid pair (two grids), with accompanying rotation and translation, can be used if one grid has one more slit than the other grid, and if the detector is modified.

Portable compton gamma-ray detection system

DOEpatents

Rowland, Mark S [Alamo, CA; Oldaker, Mark E [Pleasanton, CA

2008-03-04

A Compton scattered gamma-ray detector system. The system comprises a gamma-ray spectrometer and an annular array of individual scintillators. The scintillators are positioned so that they are arrayed around the gamma-ray spectrometer. The annular array of individual scintillators includes a first scintillator. A radiation shield is positioned around the first scintillator. A multi-channel analyzer is operatively connected to the gamma-ray spectrometer and the annular array of individual scintillators.

MO-FG-202-06: Improving the Performance of Gamma Analysis QA with Radiomics- Based Image Analysis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wootton, L; Nyflot, M; Ford, E

2016-06-15

Purpose: The use of gamma analysis for IMRT quality assurance has well-known limitations. Traditionally, a simple thresholding technique is used to evaluated passing criteria. However, like any image the gamma distribution is rich in information which thresholding mostly discards. We therefore propose a novel method of analyzing gamma images that uses quantitative image features borrowed from radiomics, with the goal of improving error detection. Methods: 368 gamma images were generated from 184 clinical IMRT beams. For each beam the dose to a phantom was measured with EPID dosimetry and compared to the TPS dose calculated with and without normally distributedmore » (2mm sigma) errors in MLC positions. The magnitude of 17 intensity histogram and size-zone radiomic features were derived from each image. The features that differed most significantly between image sets were determined with ROC analysis. A linear machine-learning model was trained on these features to classify images as with or without errors on 180 gamma images.The model was then applied to an independent validation set of 188 additional gamma distributions, half with and half without errors. Results: The most significant features for detecting errors were histogram kurtosis (p=0.007) and three size-zone metrics (p<1e-6 for each). The sizezone metrics detected clusters of high gamma-value pixels under mispositioned MLCs. The model applied to the validation set had an AUC of 0.8, compared to 0.56 for traditional gamma analysis with the decision threshold restricted to 98% or less. Conclusion: A radiomics-based image analysis method was developed that is more effective in detecting error than traditional gamma analysis. Though the pilot study here considers only MLC position errors, radiomics-based methods for other error types are being developed, which may provide better error detection and useful information on the source of detected errors. This work was partially supported by a grant from the

A novel design for scintillator-based neutron and gamma imaging in inertial confinement fusion

NASA Astrophysics Data System (ADS)

Geppert-Kleinrath, Verena; Cutler, Theresa; Danly, Chris; Madden, Amanda; Merrill, Frank; Tybo, Josh; Volegov, Petr; Wilde, Carl

2017-10-01

The LANL Advanced Imaging team has been providing reliable 2D neutron imaging of the burning fusion fuel at NIF for years, revealing possible multi-dimensional asymmetries in the fuel shape, and therefore calling for additional views. Adding a passive imaging system using image plate techniques along a new polar line of sight has recently demonstrated the merit of 3D neutron image reconstruction. Now, the team is in the process of designing a new active neutron imaging system for an additional equatorial view. The design will include a gamma imaging system as well, to allow for the imaging of carbon in the ablator of the NIF fuel capsules, constraining the burning fuel shape even further. The selection of ideal scintillator materials for a position-sensitive detector system is the key component for the new design. A comprehensive study of advanced scintillators has been carried out at the Los Alamos Neutron Science Center and the OMEGA Laser Facility in Rochester, NY. Neutron radiography using a fast-gated CCD camera system delivers measurements of resolution, light output and noise characteristics. The measured performance parameters inform the novel design, for which we conclude the feasibility of monolithic scintillators over pixelated counterparts.

The Advanced Gamma-Ray Imaging System (AGIS)

NASA Astrophysics Data System (ADS)

Williams, David A.; AGIS Collaboration

2009-01-01

The spectacular astrophysical discoveries made by the present generation of ground-based gamma-ray observatories have opened a new era in the exploration of the highest energy Universe and have conclusively established the field of very-high-energy (VHE) astronomy, covering the energy regime above about 50 GeV. The detection of nearly 100 galactic and extragalactic sources has generated considerable interest in the astronomy, astrophysics and particle physics communities and has stimulated ambitious ideas and plans for future gamma-ray observatories. AGIS is a concept for a next generation VHE observatory with a collecting area on the scale of a square kilometer being developed by an international collaboration. It would have significantly improved angular and energy resolution, increased field of view, and an order of magnitude increase in sensitivity over existing space or ground-based instruments in the energy range 40 GeV to 100 TeV. The scientific motivations and R&D roadmap for AGIS will be discussed.

Gamma-ray lens development status for a European gamma-ray imager

NASA Astrophysics Data System (ADS)

Frontera, F.; Pisa, A.; Carassiti, V.; Evangelisti, F.; Loffredo, G.; Pellicciotta, D.; Andersen, K. H.; Courtois, P.; Amati, L.; Caroli, E.; Franceschini, T.; Landini, G.; Silvestri, S.; Stephen, J. B.

2006-06-01

A breakthrough in the sensitivity level of the hard X-/gamma-ray telescopes, which today are based on detectors that view the sky through (or not) coded masks, is expected when focusing optics will be available also in this energy range. Focusing techniques are now in an advanced stage of development. To date the most efficient technique to focus hard X-rays with energies above 100 keV appears to be the Bragg diffraction from crystals in transmission configuration (Laue lenses). Crystals with mosaic structure appear to be the most suitable to build a Laue lens with a broad passband, even though other alternative structures are being investigated. The goal of our project is the development of a broad band focusing telescope based on gamma-ray lenses for the study of the continuum emission of celestial sources from 60 keV up to >600 keV. We will report details of our project, its development status and results of our assessment study of a lens configuration for the European Gamma Ray Imager (GRI) mission now under study for the ESA plan Cosmic Vision 2015-2025.

A laboratory demonstration of high-resolution hard X-ray and gamma-ray imaging using Fourier-transform techniques

NASA Technical Reports Server (NTRS)

Palmer, David; Prince, Thomas A.

1987-01-01

A laboratory imaging system has been developed to study the use of Fourier-transform techniques in high-resolution hard X-ray and gamma-ray imaging, with particular emphasis on possible applications to high-energy astronomy. Considerations for the design of a Fourier-transform imager and the instrumentation used in the laboratory studies is described. Several analysis methods for image reconstruction are discussed including the CLEAN algorithm and maximum entropy methods. Images obtained using these methods are presented.

Unified Digital Image Display And Processing System

NASA Astrophysics Data System (ADS)

Horii, Steven C.; Maguire, Gerald Q.; Noz, Marilyn E.; Schimpf, James H.

1981-11-01

Our institution like many others, is faced with a proliferation of medical imaging techniques. Many of these methods give rise to digital images (e.g. digital radiography, computerized tomography (CT) , nuclear medicine and ultrasound). We feel that a unified, digital system approach to image management (storage, transmission and retrieval), image processing and image display will help in integrating these new modalities into the present diagnostic radiology operations. Future techniques are likely to employ digital images, so such a system could readily be expanded to include other image sources. We presently have the core of such a system. We can both view and process digital nuclear medicine (conventional gamma camera) images, positron emission tomography (PET) and CT images on a single system. Images from our recently installed digital radiographic unit can be added. Our paper describes our present system, explains the rationale for its configuration, and describes the directions in which it will expand.

Particle Swarm Imaging (PSIM) - Innovative Gamma-Ray Assay - 13497

DOE Office of Scientific and Technical Information (OSTI.GOV)

Parvin, Daniel; Clarke, Sean; Humes, Sarah J.

2013-07-01

Particle Swarm Imaging is an innovative technique used to perform quantitative gamma-ray assay. The innovation overcomes some of the difficulties associated with the accurate measurement and declaration of measurement uncertainties of radionuclide inventories within waste items when the distribution of activity is unknown. Implementation requires minimal equipment, with field measurements and results obtained using only a single electrically cooled HRGS gamma-ray detector. Examples of its application in the field are given in this paper. (authors)

The HURRA filter: An easy method to eliminate collimator artifacts in high-energy gamma camera images.

PubMed

Perez-Garcia, H; Barquero, R

The correct determination and delineation of tumor/organ size is crucial in 2-D imaging in 131 I therapy. These images are usually obtained using a system composed of a Gamma camera and high-energy collimator, although the system can produce artifacts in the image. This article analyses these artifacts and describes a correction filter that can eliminate those collimator artifacts. Using free software, ImageJ, a central profile in the image is obtained and analyzed. Two components can be seen in the fluctuation of the profile: one associated with the stochastic nature of the radiation, plus electronic noise and the other periodically across the position in space due to the collimator. These frequencies are analytically obtained and compared with the frequencies in the Fourier transform of the profile. A specially developed filter removes the artifacts in the 2D Fourier transform of the DICOM image. This filter is tested using a 15-cm-diameter Petri dish with 131 I radioactive water (big object size) image, a 131 I clinical pill (small object size) image, and an image of the remainder of the lesion of two patients treated with 3.7GBq (100mCi), and 4.44GBq (120mCi) of 131 I, respectively, after thyroidectomy. The artifact is due to the hexagonal periodic structure of the collimator. The use of the filter on large-sized images reduces the fluctuation by 5.8-3.5%. In small-sized images, the FWHM can be determined in the filtered image, while this is impossible in the unfiltered image. The definition of tumor boundary and the visualization of the activity distribution inside patient lesions improve drastically when the filter is applied to the corresponding images obtained with HE gamma camera. The HURRA filter removes the artifact of high-energy collimator artifacts in planar images obtained with a Gamma camera without reducing the image resolution. It can be applied in any study of patient quantification because the number of counts remains invariant. The filter makes

Digital gamma-gamma coincidence HPGe system for environmental analysis.

PubMed

Marković, Nikola; Roos, Per; Nielsen, Sven Poul

2017-08-01

The performance of a new gamma-gamma coincidence spectrometer system for environmental samples analysis at the Center for Nuclear Technologies of the Technical University of Denmark (DTU) is reported. Nutech Coincidence Low Energy Germanium Sandwich (NUCLeGeS) system consists of two HPGe detectors in a surface laboratory with a digital acquisition system used to collect the data in time-stamped list mode with 10ns time resolution. The spectrometer is used in both anticoincidence and coincidence modes. Copyright © 2017 Elsevier Ltd. All rights reserved.

Single-Grid-Pair Fourier Telescope for Imaging in Hard-X Rays and gamma Rays

NASA Technical Reports Server (NTRS)

Campbell, Jonathan

2008-01-01

This instrument, a proposed Fourier telescope for imaging in hard-x rays and gamma rays, would contain only one pair of grids made of an appropriate radiation-absorpting/ scattering material, in contradistinction to multiple pairs of such as grids in prior Fourier x- and gamma-ray telescopes. This instrument would also include a relatively coarse gridlike image detector appropriate to the radiant flux to be imaged. Notwithstanding the smaller number of grids and the relative coarseness of the imaging detector, the images produced by the proposed instrument would be of higher quality.

Gamma-Ray Imaging Probes.

NASA Astrophysics Data System (ADS)

Wild, Walter James

1988-12-01

External nuclear medicine diagnostic imaging of early primary and metastatic lung cancer tumors is difficult due to the poor sensitivity and resolution of existing gamma cameras. Nonimaging counting detectors used for internal tumor detection give ambiguous results because distant background variations are difficult to discriminate from neighboring tumor sites. This suggests that an internal imaging nuclear medicine probe, particularly an esophageal probe, may be advantageously used to detect small tumors because of the ability to discriminate against background variations and the capability to get close to sites neighboring the esophagus. The design, theory of operation, preliminary bench tests, characterization of noise behavior and optimization of such an imaging probe is the central theme of this work. The central concept lies in the representation of the aperture shell by a sequence of binary digits. This, coupled with the mode of operation which is data encoding within an axial slice of space, leads to the fundamental imaging equation in which the coding operation is conveniently described by a circulant matrix operator. The coding/decoding process is a classic coded-aperture problem, and various estimators to achieve decoding are discussed. Some estimators require a priori information about the object (or object class) being imaged; the only unbiased estimator that does not impose this requirement is the simple inverse-matrix operator. The effects of noise on the estimate (or reconstruction) is discussed for general noise models and various codes/decoding operators. The choice of an optimal aperture for detector count times of clinical relevance is examined using a statistical class-separability formalism.

Active neutron and gamma-ray imaging of highly enriched uranium for treaty verification

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hamel, Michael C.; Polack, J. Kyle; Ruch, Marc L.

The detection and characterization of highly enriched uranium (HEU) presents a large challenge in the non-proliferation field. HEU has a low neutron emission rate and most gamma rays are low energy and easily shielded. To address this challenge, an instrument known as the dual-particle imager (DPI) was used with a portable deuterium-tritium (DT) neutron generator to detect neutrons and gamma rays from induced fission in HEU. We evaluated system response using a 13.7-kg HEU sphere in several configurations with no moderation, high-density polyethylene (HDPE) moderation, and tungsten moderation. A hollow tungsten sphere was interrogated to evaluate the response to amore » possible hoax item. First, localization capabilities were demonstrated by reconstructing neutron and gamma-ray images. Once localized, additional properties such as fast neutron energy spectra and time-dependent neutron count rates were attributed to the items. For the interrogated configurations containing HEU, the reconstructed neutron spectra resembled Watt spectra, which gave confidence that the interrogated items were undergoing induced fission. The time-dependent neutron count rate was also compared for each configuration and shown to be dependent on the neutron multiplication of the item. This result showed that the DPI is a viable tool for localizing and confirming fissile mass and multiplication.« less

Active neutron and gamma-ray imaging of highly enriched uranium for treaty verification

DOE PAGES

Hamel, Michael C.; Polack, J. Kyle; Ruch, Marc L.; ...

2017-08-11

The detection and characterization of highly enriched uranium (HEU) presents a large challenge in the non-proliferation field. HEU has a low neutron emission rate and most gamma rays are low energy and easily shielded. To address this challenge, an instrument known as the dual-particle imager (DPI) was used with a portable deuterium-tritium (DT) neutron generator to detect neutrons and gamma rays from induced fission in HEU. We evaluated system response using a 13.7-kg HEU sphere in several configurations with no moderation, high-density polyethylene (HDPE) moderation, and tungsten moderation. A hollow tungsten sphere was interrogated to evaluate the response to amore » possible hoax item. First, localization capabilities were demonstrated by reconstructing neutron and gamma-ray images. Once localized, additional properties such as fast neutron energy spectra and time-dependent neutron count rates were attributed to the items. For the interrogated configurations containing HEU, the reconstructed neutron spectra resembled Watt spectra, which gave confidence that the interrogated items were undergoing induced fission. The time-dependent neutron count rate was also compared for each configuration and shown to be dependent on the neutron multiplication of the item. This result showed that the DPI is a viable tool for localizing and confirming fissile mass and multiplication.« less

Characterization and Applications of a CdZnTe-Based Gamma-Ray Imager

NASA Astrophysics Data System (ADS)

Galloway, Michelle Lee

Detection of electromagnetic radiation in the form of gamma rays provides a means to discover the presence of nuclear sources and the occurrence of highly-energetic events that occur in our terrestrial and astrophysical environment. The highly penetrative nature of gamma rays allows for probing into objects and regions that are obscured at other wavelengths. The detection and imaging of gamma rays relies upon an understanding of the ways in which these high-energy photons interact with matter. The applications of gamma-ray detection and imaging are numerous. Astrophysical observation of gamma rays expands our understanding of the Universe in which we live. Terrestrial detection and imaging of gamma rays enable environmental monitoring of radioactivity. This allows for identification and localization of nuclear materials to prevent illicit trafficking and to ultimately protect against harmful acts. This dissertation focusses on the development and characterization of a gamma-ray detection and imaging instrument and explores its capabilities for the aforementioned applications. The High Efficiency Multimode Imager, HEMI, is a prototype instrument that is based on Cadmium Zinc Telluride (CdZnTe) semiconductor detectors. The detectors are arranged in a two-planar configuration to allow for both Compton and coded-aperture imaging. HEMI was initially developed as a prototype instrument to demonstrate its capabilities for nuclear threat detection, spectroscopy, and imaging. The 96-detector instrument was developed and fully characterized within the laboratory environment, yielding a system energy resolution of 2.4% FWHM at 662 keV, an angular resolution of 9.5 deg. FWHM at 662 keV in Compton mode, and a 10.6 deg. angular resolution in coded aperture mode. After event cuts, the effective area for Compton imaging of the 662 keV photopeak is 0.1 cm 22. Imaging of point sources in both Compton and coded aperture modes have been demonstrated. The minimum detectable activity of

A Spherical Active Coded Aperture for 4π Gamma-ray Imaging

DOE PAGES

Hellfeld, Daniel; Barton, Paul; Gunter, Donald; ...

2017-09-22

Gamma-ray imaging facilitates the efficient detection, characterization, and localization of compact radioactive sources in cluttered environments. Fieldable detector systems employing active planar coded apertures have demonstrated broad energy sensitivity via both coded aperture and Compton imaging modalities. But, planar configurations suffer from a limited field-of-view, especially in the coded aperture mode. In order to improve upon this limitation, we introduce a novel design by rearranging the detectors into an active coded spherical configuration, resulting in a 4pi isotropic field-of-view for both coded aperture and Compton imaging. This work focuses on the low- energy coded aperture modality and the optimization techniquesmore » used to determine the optimal number and configuration of 1 cm 3 CdZnTe coplanar grid detectors on a 14 cm diameter sphere with 192 available detector locations.« less

Prompt Gamma Imaging for In Vivo Range Verification of Pencil Beam Scanning Proton Therapy.

PubMed

Xie, Yunhe; Bentefour, El Hassane; Janssens, Guillaume; Smeets, Julien; Vander Stappen, François; Hotoiu, Lucian; Yin, Lingshu; Dolney, Derek; Avery, Stephen; O'Grady, Fionnbarr; Prieels, Damien; McDonough, James; Solberg, Timothy D; Lustig, Robert A; Lin, Alexander; Teo, Boon-Keng K

2017-09-01

To report the first clinical results and value assessment of prompt gamma imaging for in vivo proton range verification in pencil beam scanning mode. A stand-alone, trolley-mounted, prototype prompt gamma camera utilizing a knife-edge slit collimator design was used to record the prompt gamma signal emitted along the proton tracks during delivery of proton therapy for a brain cancer patient. The recorded prompt gamma depth detection profiles of individual pencil beam spots were compared with the expected profiles simulated from the treatment plan. In 6 treatment fractions recorded over 3 weeks, the mean (± standard deviation) range shifts aggregated over all spots in 9 energy layers were -0.8 ± 1.3 mm for the lateral field, 1.7 ± 0.7 mm for the right-superior-oblique field, and -0.4 ± 0.9 mm for the vertex field. This study demonstrates the feasibility and illustrates the distinctive benefits of prompt gamma imaging in pencil beam scanning treatment mode. Accuracy in range verification was found in this first clinical case to be better than the range uncertainty margin applied in the treatment plan. These first results lay the foundation for additional work toward tighter integration of the system for in vivo proton range verification and quantification of range uncertainties. Copyright © 2017 Elsevier Inc. All rights reserved.

Development of a Dual-Particle Imaging System for Nonproliferation Applications

NASA Astrophysics Data System (ADS)

Poitrasson-Riviere, Alexis Pierre Valere

A rising concern in our society is preventing the proliferation of nuclear weapons and fissionable material. This prevention can be incorporated at multiple levels, from the use of nuclear safeguards in nuclear facilities to the detection of threat objects in the field. At any level, systems used for such tasks need to be specially designed for use with Special Nuclear Material (SNM) which is defined by the NRC as plutonium and uranium enriched in U-233 or U-235 isotopes. These radioactive materials have the particularity of emitting both fast neutrons and gamma rays; thus, systems able to detect both particles simultaneously are particularly desirable. In the field of nuclear nonproliferation and safeguards, detection systems capable of accurately imaging various sources of radiation can greatly simplify any monitoring or detection task. The localization of the radiation sources can allow users of the system to focus their efforts on the areas of interest, whether it be for radiation detection or radiation characterization. This thesis describes the development of a dual-particle imaging system at the University of Michigan to address these technical challenges. The imaging system relies on the use of organic liquid scintillators that can detect both fast neutrons and gamma rays, and inorganic NaI(Tl) scintillators that are not very sensitive to neutrons yet yield photoelectric absorptions from gamma rays. A prototype of the imaging system has been constructed and operated. The system will aid the remote monitoring of nuclear materials within facilities, and it has the scalability for standoff detection in the field. A software suite has been developed to analyze measured data in real time, in an effort to obtain a system as close to field-ready as possible. The system's performance has been tested with various materials of interest, such as MOX and plutonium metal, measured at the PERLA facility of the Joint Research Center in Ispra, Italy. The robust and

An analog gamma correction scheme for high dynamic range CMOS logarithmic image sensors.

PubMed

Cao, Yuan; Pan, Xiaofang; Zhao, Xiaojin; Wu, Huisi

2014-12-15

In this paper, a novel analog gamma correction scheme with a logarithmic image sensor dedicated to minimize the quantization noise of the high dynamic applications is presented. The proposed implementation exploits a non-linear voltage-controlled-oscillator (VCO) based analog-to-digital converter (ADC) to perform the gamma correction during the analog-to-digital conversion. As a result, the quantization noise does not increase while the same high dynamic range of logarithmic image sensor is preserved. Moreover, by combining the gamma correction with the analog-to-digital conversion, the silicon area and overall power consumption can be greatly reduced. The proposed gamma correction scheme is validated by the reported simulation results and the experimental results measured for our designed test structure, which is fabricated with 0.35 μm standard complementary-metal-oxide-semiconductor (CMOS) process.

An Analog Gamma Correction Scheme for High Dynamic Range CMOS Logarithmic Image Sensors

PubMed Central

Cao, Yuan; Pan, Xiaofang; Zhao, Xiaojin; Wu, Huisi

2014-01-01

In this paper, a novel analog gamma correction scheme with a logarithmic image sensor dedicated to minimize the quantization noise of the high dynamic applications is presented. The proposed implementation exploits a non-linear voltage-controlled-oscillator (VCO) based analog-to-digital converter (ADC) to perform the gamma correction during the analog-to-digital conversion. As a result, the quantization noise does not increase while the same high dynamic range of logarithmic image sensor is preserved. Moreover, by combining the gamma correction with the analog-to-digital conversion, the silicon area and overall power consumption can be greatly reduced. The proposed gamma correction scheme is validated by the reported simulation results and the experimental results measured for our designed test structure, which is fabricated with 0.35 μm standard complementary-metal-oxide-semiconductor (CMOS) process. PMID:25517692

Infrared traffic image enhancement algorithm based on dark channel prior and gamma correction

NASA Astrophysics Data System (ADS)

Zheng, Lintao; Shi, Hengliang; Gu, Ming

2017-07-01

The infrared traffic image acquired by the intelligent traffic surveillance equipment has low contrast, little hierarchical differences in perceptions of image and the blurred vision effect. Therefore, infrared traffic image enhancement, being an indispensable key step, is applied to nearly all infrared imaging based traffic engineering applications. In this paper, we propose an infrared traffic image enhancement algorithm that is based on dark channel prior and gamma correction. In existing research dark channel prior, known as a famous image dehazing method, here is used to do infrared image enhancement for the first time. Initially, in the proposed algorithm, the original degraded infrared traffic image is transformed with dark channel prior as the initial enhanced result. A further adjustment based on the gamma curve is needed because initial enhanced result has lower brightness. Comprehensive validation experiments reveal that the proposed algorithm outperforms the current state-of-the-art algorithms.

Imaging of gamma-Irradiated Regions of a Crystal

NASA Technical Reports Server (NTRS)

Dragoi, Danut; McClure, Steven; Johnston, Allan; Chao, Tien-Hsin

2004-01-01

A holographic technique has been devised for generating a visible display of the effect of exposure of a photorefractive crystal to gamma rays. The technique exploits the space charge that results from trapping of electrons in defects induced by gamma rays. The technique involves a three-stage process. In the first stage, one writes a holographic pattern in the crystal by use of the apparatus shown in Figure 1. A laser beam of 532-nm wavelength is collimated and split into signal and reference beams by use of a polarizing beam splitter. On its way to the crystal, the reference beam goes through a two-dimensional optical scanner that contains two pairs of lenses (L1y, L2y and L1x,L2x) and mirrors M1 and M2, which can be rotated by use of micrometer drives to make fine adjustments. The signal beam is sent through a spatial light modulator that imposes the holographic pattern, then through two imaging lenses L(sub img) on its way to the crystal. An aperture is placed at the common focus of lenses Limg to suppress high-order diffraction from the spatial light modulator. The hologram is formed by interference between the signal and reference beams. A camera lens focuses an image of the interior of the crystal onto a charge-coupled device (CCD). If the crystal is illuminated by only the reference beam once the hologram has been formed, then an image of the hologram is formed on the CCD: this phenomenon is exploited to make visible the pattern of gamma irradiation of the crystal, as described next. In the second stage of the process, the crystal is removed from the holographic apparatus and irradiated with rays at a dose of about 100 krad. In the third stage of the process, the crystal is remounted in the holographic apparatus in the same position as in the first stage and illuminated with only the reference beam to obtain the image of the hologram as modified by the effect of the rays. The orientations of M1 and M2 can be adjusted slightly, if necessary, to maximize the

Image Processor Electronics (IPE): The High-Performance Computing System for NASA SWIFT Mission

NASA Technical Reports Server (NTRS)

Nguyen, Quang H.; Settles, Beverly A.

2003-01-01

Gamma Ray Bursts (GRBs) are believed to be the most powerful explosions that have occurred in the Universe since the Big Bang and are a mystery to the scientific community. Swift, a NASA mission that includes international participation, was designed and built in preparation for a 2003 launch to help to determine the origin of Gamma Ray Bursts. Locating the position in the sky where a burst originates requires intensive computing, because the duration of a GRB can range between a few milliseconds up to approximately a minute. The instrument data system must constantly accept multiple images representing large regions of the sky that are generated by sixteen gamma ray detectors operating in parallel. It then must process the received images very quickly in order to determine the existence of possible gamma ray bursts and their locations. The high-performance instrument data computing system that accomplishes this is called the Image Processor Electronics (IPE). The IPE was designed, built and tested by NASA Goddard Space Flight Center (GSFC) in order to meet these challenging requirements. The IPE is a small size, low power and high performing computing system for space applications. This paper addresses the system implementation and the system hardware architecture of the IPE. The paper concludes with the IPE system performance that was measured during end-to-end system testing.

Characterization of system-related geometric distortions in MR images employed in Gamma Knife radiosurgery applications.

PubMed

Pappas, E P; Seimenis, I; Moutsatsos, A; Georgiou, E; Nomikos, P; Karaiskos, P

2016-10-07

This work provides characterization of system-related geometric distortions present in MRIs used in Gamma Knife (GK) stereotactic radiosurgery (SRS) treatment planning. A custom-made phantom, compatible with the Leksell stereotactic frame model G and encompassing 947 control points (CPs), was utilized. MR images were obtained with and without the frame, thus allowing discrimination of frame-induced distortions. In the absence of the frame and following compensation for field inhomogeneities, measured average CP disposition owing to gradient nonlinearities was 0.53 mm. In presence of the frame, contrarily, detected distortion was greatly increased (up to about 5 mm) in the vicinity of the frame base due to eddy currents induced in the closed loop of its aluminum material. Frame-related distortion was obliterated at approximately 90 mm from the frame base. Although the region with the maximum observed distortion may not lie within the GK treatable volume, the presence of the frame results in distortion of the order of 1.5 mm at a 7 cm distance from the center of the Leksell space. Additionally, severe distortions observed outside the treatable volume could possibly impinge on the delivery accuracy mainly by adversely affecting the registration process (e.g. the position of the lower part of the N-shaped fiducials used to define the stereotactic space may be miss-registered). Images acquired with a modified version of the frame developed by replacing its front side with an acrylic bar, thus interrupting the closed aluminum loop and reducing the induced eddy currents, were shown to benefit from relatively reduced distortion. System-related distortion was also identified in patient MR images. Using corresponding CT angiography images as a reference, an offset of 1.1 mm was detected for two vessels lying in close proximity to the frame base, while excellent spatial agreement was observed for a vessel far apart from the frame base.

Characterization of system-related geometric distortions in MR images employed in Gamma Knife radiosurgery applications

NASA Astrophysics Data System (ADS)

Pappas, E. P.; Seimenis, I.; Moutsatsos, A.; Georgiou, E.; Nomikos, P.; Karaiskos, P.

2016-10-01

This work provides characterization of system-related geometric distortions present in MRIs used in Gamma Knife (GK) stereotactic radiosurgery (SRS) treatment planning. A custom-made phantom, compatible with the Leksell stereotactic frame model G and encompassing 947 control points (CPs), was utilized. MR images were obtained with and without the frame, thus allowing discrimination of frame-induced distortions. In the absence of the frame and following compensation for field inhomogeneities, measured average CP disposition owing to gradient nonlinearities was 0.53 mm. In presence of the frame, contrarily, detected distortion was greatly increased (up to about 5 mm) in the vicinity of the frame base due to eddy currents induced in the closed loop of its aluminum material. Frame-related distortion was obliterated at approximately 90 mm from the frame base. Although the region with the maximum observed distortion may not lie within the GK treatable volume, the presence of the frame results in distortion of the order of 1.5 mm at a 7 cm distance from the center of the Leksell space. Additionally, severe distortions observed outside the treatable volume could possibly impinge on the delivery accuracy mainly by adversely affecting the registration process (e.g. the position of the lower part of the N-shaped fiducials used to define the stereotactic space may be miss-registered). Images acquired with a modified version of the frame developed by replacing its front side with an acrylic bar, thus interrupting the closed aluminum loop and reducing the induced eddy currents, were shown to benefit from relatively reduced distortion. System-related distortion was also identified in patient MR images. Using corresponding CT angiography images as a reference, an offset of 1.1 mm was detected for two vessels lying in close proximity to the frame base, while excellent spatial agreement was observed for a vessel far apart from the frame base.

High-sensitivity, high-speed continuous imaging system

DOEpatents

Watson, Scott A; Bender, III, Howard A

2014-11-18

A continuous imaging system for recording low levels of light typically extending over small distances with high-frame rates and with a large number of frames is described. Photodiode pixels disposed in an array having a chosen geometry, each pixel having a dedicated amplifier, analog-to-digital convertor, and memory, provide parallel operation of the system. When combined with a plurality of scintillators responsive to a selected source of radiation, in a scintillator array, the light from each scintillator being directed to a single corresponding photodiode in close proximity or lens-coupled thereto, embodiments of the present imaging system may provide images of x-ray, gamma ray, proton, and neutron sources with high efficiency.

Enhanced Analysis Techniques for an Imaging Neutron and Gamma Ray Spectrometer

NASA Astrophysics Data System (ADS)

Madden, Amanda C.

The presence of gamma rays and neutrons is a strong indicator of the presence of Special Nuclear Material (SNM). The imaging Neutron and gamma ray SPECTrometer (NSPECT) developed by the University of New Hampshire and Michigan Aerospace corporation detects the fast neutrons and prompt gamma rays from fissile material, and the gamma rays from radioactive material. The instrument operates as a double scatter device, requiring a neutron or a gamma ray to interact twice in the instrument. While this detection requirement decreases the efficiency of the instrument, it offers superior background rejection and the ability to measure the energy and momentum of the incident particle. These measurements create energy spectra and images of the emitting source for source identification and localization. The dual species instrument provides superior detection than a single species alone. In realistic detection scenarios, few particles are detected from a potential threat due to source shielding, detection at a distance, high background, and weak sources. This contributes to a small signal to noise ratio, and threat detection becomes difficult. To address these difficulties, several enhanced data analysis tools were developed. A Receiver Operating Characteristic Curve (ROC) helps set instrumental alarm thresholds as well as to identify the presence of a source. Analysis of a dual-species ROC curve provides superior detection capabilities. Bayesian analysis helps to detect and identify the presence of a source through model comparisons, and helps create a background corrected count spectra for enhanced spectroscopy. Development of an instrument response using simulations and numerical analyses will help perform spectra and image deconvolution. This thesis will outline the principles of operation of the NSPECT instrument using the double scatter technology, traditional analysis techniques, and enhanced analysis techniques as applied to data from the NSPECT instrument, and an

Intraoperative Imaging Guidance for Sentinel Node Biopsy in Melanoma Using a Mobile Gamma Camera

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dengel, Lynn T; Judy, Patricia G; Petroni, Gina R

2011-04-01

The objective is to evaluate the sensitivity and clinical utility of intraoperative mobile gamma camera (MGC) imaging in sentinel lymph node biopsy (SLNB) in melanoma. The false-negative rate for SLNB for melanoma is approximately 17%, for which failure to identify the sentinel lymph node (SLN) is a major cause. Intraoperative imaging may aid in detection of SLN near the primary site, in ambiguous locations, and after excision of each SLN. The present pilot study reports outcomes with a prototype MGC designed for rapid intraoperative image acquisition. We hypothesized that intraoperative use of the MGC would be feasible and that sensitivitymore » would be at least 90%. From April to September 2008, 20 patients underwent Tc99 sulfur colloid lymphoscintigraphy, and SLNB was performed with use of a conventional fixed gamma camera (FGC), and gamma probe followed by intraoperative MGC imaging. Sensitivity was calculated for each detection method. Intraoperative logistical challenges were scored. Cases in which MGC provided clinical benefit were recorded. Sensitivity for detecting SLN basins was 97% for the FGC and 90% for the MGC. A total of 46 SLN were identified: 32 (70%) were identified as distinct hot spots by preoperative FGC imaging, 31 (67%) by preoperative MGC imaging, and 43 (93%) by MGC imaging pre- or intraoperatively. The gamma probe identified 44 (96%) independent of MGC imaging. The MGC provided defined clinical benefit as an addition to standard practice in 5 (25%) of 20 patients. Mean score for MGC logistic feasibility was 2 on a scale of 1-9 (1 = best). Intraoperative MGC imaging provides additional information when standard techniques fail or are ambiguous. Sensitivity is 90% and can be increased. This pilot study has identified ways to improve the usefulness of an MGC for intraoperative imaging, which holds promise for reducing false negatives of SLNB for melanoma.« less

Gamma-ray imaging and holdup assays of 235-F PuFF cells 1 & 2

DOE Office of Scientific and Technical Information (OSTI.GOV)

Aucott, T.

Savannah River National Laboratory (SRNL) Nuclear Measurements (L4120) was tasked with performing enhanced characterization of the holdup in the PuFF shielded cells. Assays were performed in accordance with L16.1-ADS-2460 using two high-resolution gamma-ray detectors. The first detector, an In Situ Object Counting System (ISOCS)-characterized detector, was used in conjunction with the ISOCS Geometry Composer software to quantify grams of holdup. The second detector, a Germanium Gamma-ray Imager (GeGI), was used to visualize the location and relative intensity of the holdup in the cells. Carts and collimators were specially designed to perform optimum assays of the cells. Thick, pencil-beam tungsten collimatorsmore » were fabricated to allow for extremely precise targeting of items of interest inside the cells. Carts were designed with a wide range of motion to position and align the detectors. A total of 24 measurements were made, each typically 24 hours or longer to provide sufficient statistical precision. This report presents the results of the enhanced characterization for cells 1 and 2. The measured gram values agree very well with results from the 2014 study. In addition, images were created using both the 2014 data and the new GeGI data. The GeGI images of the cells walls reveal significant Pu-238 holdup on the surface of the walls in cells 1 and 2. Additionally, holdup is visible in the two pass-throughs from cell 1 to the wing cabinets. This report documents the final element (exterior measurements coupled with gamma-ray imaging and modeling) of the enhanced characterization of cells 1-5 (East Cell Line).« less

Gamma-telescopes Fermi/LAT and GAMMA-400 Trigger Systems Event Recognizing Methods Comparison

NASA Astrophysics Data System (ADS)

Arkhangelskaja, I. V.; Murchenko, A. E.; Chasovikov, E. N.; Arkhangelskiy, A. I.; Kheymits, M. D.

Usually instruments for high-energy γ-quanta registration consists of converter (where γ-quanta produced pairs) and calorimeter for particles energy measurements surrounded by anticoincidence shield used to events identification (whether incident particle was charged or neutral). The influence of pair formation by γ-quanta in shield and the backsplash (moved in the opposite direction particles created due high energy γ-rays interact with calorimeter) should be taken into account. It leads to decrease both effective area and registration efficiency at E>10 GeV. In the presented article the event recognizing methods used in Fermi/LAT trigger system is considered in comparison with the ones applied in counting and triggers signals formation system of gamma-telescope GAMMA-400. The GAMMA-400 (Gamma Astronomical Multifunctional Modular Apparatus) will be the new high-apogee space γ-observatory. The GAMMA-400 consist of converter-tracker based on silicon-strip coordinate detectors interleaved with tungsten foils, imaging calorimeter make of 2 layers of double (x, y) silicon strip coordinate detectors interleaved with planes of CsI(Tl) crystals and the electromagnetic calorimeter CC2 consists only of CsI(Tl) crystals. Several plastics detections systems used as anticoincidence shield, for particles energy and moving direction estimations. The main differences of GAMMA-400 constructions from Fermi/LAT one are using the time-of-flight system with base of 50 cm and double layer structure of plastic detectors provides more effective particles direction definition and backsplash rejection. Also two calorimeters in GAMMA-400 composed the total absorbtion spectrometer with total thickness ∼ 25 X0 or ∼1.2 λ0 for vertical incident particles registration and 54 X0 or 2.5 λ0 for laterally incident ones (where λ0 is nuclear interaction length). It provides energy resolution 1-2% for 10 GeV-3.0×103 GeV events while the Fermi/LAT energy resolution does not reach such a

Imaging observations of SN1987A at gamma-ray energies

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cook, W.R.; Palmer, D.M.; Prince, T.A.

1988-09-25

The Caltech imaging ..gamma..-ray telescope was launched by balloon from Alice Springs, NT, Australia for observations of SN1987A during the period 18.60--18.87 November 1987 UT. The preliminary results presented here are derived from 8200 seconds of instrument livetime on the supernova and 2500 seconds on the Crab Nebula and pulsar at a float altitude of 37 km. We have obtained the first images of the SN1987A region at ..gamma..-ray energies confirming that the bulk of the ..gamma..-ray emission comes from the supernova and not from LMC X-1. A count excess is detected between 300 and 1300 keV from the directionmore » of the supernova, one third of which comes from energy bands of width 80 and 92 keV centered on 847 and 1238 keV, respectively. The excess can be interpreted as a line photon flux plus scattered photon continuum from the radioactive decay of /sup 56/Co synthesized in the supernova explosion. We compare our data to recent predictions and find it to be consistent with models invoking moderate mixing of core material into the envelope.« less

Gamma-sky.net: Portal to the gamma-ray sky

NASA Astrophysics Data System (ADS)

Voruganti, Arjun; Deil, Christoph; Donath, Axel; King, Johannes

2017-01-01

http://gamma-sky.net is a novel interactive website designed for exploring the gamma-ray sky. The Map View portion of the site is powered by the Aladin Lite sky atlas, providing a scalable survey image tesselated onto a three-dimensional sphere. The map allows for interactive pan and zoom navigation as well as search queries by sky position or object name. The default image overlay shows the gamma-ray sky observed by the Fermi-LAT gamma-ray space telescope. Other survey images (e.g. Planck microwave images in low/high frequency bands, ROSAT X-ray image) are available for comparison with the gamma-ray data. Sources from major gamma-ray source catalogs of interest (Fermi-LAT 2FHL, 3FGL and a TeV source catalog) are overlaid over the sky map as markers. Clicking on a given source shows basic information in a popup, and detailed pages for every source are available via the Catalog View component of the website, including information such as source classification, spectrum and light-curve plots, and literature references. We intend for gamma-sky.net to be applicable for both professional astronomers as well as the general public. The website started in early June 2016 and is being developed as an open-source, open data project on GitHub (https://github.com/gammapy/gamma-sky). We plan to extend it to display more gamma-ray and multi-wavelength data. Feedback and contributions are very welcome!

A study of the sensitivity of an imaging telescope (GRITS) for high energy gamma-ray astronomy

NASA Technical Reports Server (NTRS)

Yearian, Mason R.

1990-01-01

When a gamma-ray telescope is placed in Earth orbit, it is bombarded by a flux of cosmic protons much greater than the flux of interesting gammas. These protons can interact in the telescope's thermal shielding to produce detectable gamma rays, most of which are vetoed. Since the proton flux is so high, the unvetoed gamma rays constitute a significant background relative to some weak sources. This background increases the observing time required to pinpoint some sources and entirely obscures other sources. Although recent telescopes have been designed to minimize this background, its strength and spectral characteristics were not previously calculated in detail. Monte Carlo calculations are presented which characterize the strength, spectrum and other features of the cosmic proton background using FLUKA, a hadronic cascade program. Several gamma-ray telescopes, including SAS-2, EGRET and the Gamma Ray Imaging Telescope System (GRITS), are analyzed, and their proton-induced backgrounds are characterized. In all cases, the backgrounds are either shown to be low relative to interesting signals or suggestions are made which would reduce the background sufficiently to leave the telescope unimpaired. In addition, several limiting cases are examined for comparison to previous estimates and calibration measurements.

Development of Camera Electronics for the Advanced Gamma-ray Imaging System (AGIS)

NASA Astrophysics Data System (ADS)

Tajima, Hiroyasu

2009-05-01

AGIS, a next generation of atmospheric Cherenkov telescope arrays, aims to achieve a sensitivity level of a milliCrab for gamma-ray observations in in the energy band of 40 GeV to 100 TeV. Such improvement requires cost reduction of individual components with high reliability in order to equip the order of 100 telescopes necessary to achieve the sensitivity goal. We are exploring several design concepts to reduce the cost of camera electronics while improving their performance. We have developed test systems for some of these concepts and are testing their performance. Here we present test results of the test systems.

Is there a preference for linearity when viewing natural images?

NASA Astrophysics Data System (ADS)

Kane, David; Bertamío, Marcelo

2015-01-01

The system gamma of the imaging pipeline, defined as the product of the encoding and decoding gammas, is typically greater than one and is stronger for images viewed with a dark background (e.g. cinema) than those viewed in lighter conditions (e.g. office displays).1-3 However, for high dynamic range (HDR) images reproduced on a low dynamic range (LDR) monitor, subjects often prefer a system gamma of less than one,4 presumably reflecting the greater need for histogram equalization in HDR images. In this study we ask subjects to rate the perceived quality of images presented on a LDR monitor using various levels of system gamma. We reveal that the optimal system gamma is below one for images with a HDR and approaches or exceeds one for images with a LDR. Additionally, the highest quality scores occur for images where a system gamma of one is optimal, suggesting a preference for linearity (where possible). We find that subjective image quality scores can be predicted by computing the degree of histogram equalization of the lightness distribution. Accordingly, an optimal, image dependent system gamma can be computed that maximizes perceived image quality.

Simulating deep surveys of the Galactic Plane with the Advanced Gamma-ray Imaging System (AGIS)

NASA Astrophysics Data System (ADS)

Funk, Stefan; Digel, Seth

2009-05-01

The pioneering survey of the Galactic plane by H.E.S.S., together with the northern complement now underway with VERITAS, has shown the inner Milky Way to be rich in TeV-emitting sources; new source classes have been found among the H.E.S.S. detections and unidentified sources remain. In order to explore optimizations of the design of an Advanced Gamma-ray Imaging System (AGIS)-like instrument for survey science, we constructed a model of the flux and size distributions of Galactic TeV sources, normalized to the H.E.S.S. sources but extrapolated to lower flux levels. We investigated potential outcomes from a survey with the order of magnitude improvement in sensitivity and attendant improvement in angular resolution planned for AGIS. Studies of individual sources and populations found with such a sensitivity survey will advance understanding of astrophysical particle acceleration, source populations, and even high-energy cosmic rays via detection of the low-level TeV diffuse emission in regions of high cosmic-ray densitiy.

Technology Development for AGIS (Advanced Gamma-ray Imaging System).

NASA Astrophysics Data System (ADS)

Krennrich, Frank

2008-04-01

Next-generation arrays of atmospheric Cherenkov telescopes are at the conceptual planning stage and each could consist of on the order of 100 telescopes. The two currently-discussed projects AGIS in the US and CTA in Europe, have the potential to achieve an order of magnitude better sensitivity for Very High Energy (VHE) gamma-ray observations over state-to-the-art observatories. These projects require a substantial increase in scale from existing 4-telescope arrays such as VERITAS and HESS. The optimization of a large array requires exploring cost reduction and research and development for the individual elements while maximizing their performance as an array. In this context, the technology development program for AGIS will be discussed. This includes developing new optical designs, evaluating new types of photodetectors, developing fast trigger systems, integrating fast digitizers into highly-pixilated cameras, and reliability engineering of the individual components.

High Precision Grids for Neutron, Hard X-Ray, and Gamma-Ray Imaging Systems

NASA Technical Reports Server (NTRS)

Campbell, Jonathan W. (Inventor)

2002-01-01

Fourier telescopes permit observations over a very broad band of energy. They generally include synthetic spatial filtering structures, known as multilayer grids or grid pairs consisting of alternate layers of absorbing and transparent materials depending on whether neutrons or photons are being imaged. For hard x-rays and gamma rays high (absorbing) and low (transparent) atomic number elements, termed high-Z and low-Z materials may be used. Fabrication of these multilayer grid structures is not without its difficulties. Herein the alternate layers of the higher material and the lower material are inserted in a polyhedron, transparent to photons of interest, through an open face of the polyhedron. The inserted layers are then uniformly compressed to form a multilayer grid.

SU-E-T-117: Analysis of the ArcCHECK Dosimetry Gamma Failure Using the 3DVH System

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cho, S; Choi, W; Lee, H

2015-06-15

Purpose: To evaluate gamma analysis failure for the VMAT patient specific QA using ArcCHECK cylindrical phantom. The 3DVH system(Sun Nuclear, FL) was used to analyze the dose difference statistic between measured dose and treatment planning system calculated dose. Methods: Four case of gamma analysis failure were selected retrospectively. Our institution gamma analysis indexes were absolute dose, 3%/3mm and 90%pass rate in the ArcCHECK dosimetry. The collapsed cone convolution superposition (CCCS) dose calculation algorithm for VMAT was used. Dose delivery was performed with Elekta Agility. The A1SL(standard imaging, WI) and cavity plug were used for point dose measurement. Delivery QA plansmore » and images were used for 3DVH Reference data instead of patient plan and image. The measured data of ‘.txt’ file was used for comparison at diodes to acquire a global dose level. The,.acml’ file was used for AC-PDP and to calculated point dose. Results: The global dose of 3DVH was calculated as 1.10 Gy, 1.13, 1.01 and 0.2 Gy respectively. The global dose of 0.2 Gy case was induced by distance discrepancy. The TPS calculated point dose of was 2.33 Gy to 2.77 Gy and 3DVH calculated dose was 2.33 Gy to 2.68 Gy. The maximum dose differences were −2.83% and −3.1% for TPS vs. measured dose and TPS vs. 3DVH calculated respectively in the same case. The difference between measured and 3DVH was 0.1% in that case. The 3DVH gamma pass rate was 98% to 99.7%. Conclusion: We found the TPS calculation error by 3DVH calculation using ArcCHECK measured dose. It seemed that our CCCS algorithm RTP system over estimated at the central region and underestimated scattering at the peripheral diode detector point. The relative gamma analysis and point dose measurement would be recommended for VMAT DQA in the gamma failure case of ArcCHECK dosimetry.« less

Heart Imaging System

NASA Technical Reports Server (NTRS)

1993-01-01

Johnson Space Flight Center's device to test astronauts' heart function in microgravity has led to the MultiWire Gamma Camera, which images heart conditions six times faster than conventional devices. Dr. Jeffrey Lacy, who developed the technology as a NASA researcher, later formed Proportional Technologies, Inc. to develop a commercially viable process that would enable use of Tantalum-178 (Ta-178), a radio-pharmaceutical. His company supplies the generator for the radioactive Ta-178 to Xenos Medical Systems, which markets the camera. Ta-178 can only be optimally imaged with the camera. Because the body is subjected to it for only nine minutes, the radiation dose is significantly reduced and the technique can be used more frequently. Ta-178 also enables the camera to be used on pediatric patients who are rarely studied with conventional isotopes because of the high radiation dosage.

First results of electron temperature measurements by the use of multi-pass Thomson scattering system in GAMMA 10

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yoshikawa, M., E-mail: yosikawa@prc.tsukuba.ac.jp; Nagasu, K.; Shimamura, Y.

2014-11-15

A multi-pass Thomson scattering (TS) has the advantage of enhancing scattered signals. We constructed a multi-pass TS system for a polarisation-based system and an image relaying system modelled on the GAMMA 10 TS system. We undertook Raman scattering experiments both for the multi-pass setting and for checking the optical components. Moreover, we applied the system to the electron temperature measurements in the GAMMA 10 plasma for the first time. The integrated scattering signal was magnified by approximately three times by using the multi-pass TS system with four passes. The electron temperature measurement accuracy is improved by using this multi-pass system.

First results of electron temperature measurements by the use of multi-pass Thomson scattering system in GAMMA 10.

PubMed

Yoshikawa, M; Yasuhara, R; Nagasu, K; Shimamura, Y; Shima, Y; Kohagura, J; Sakamoto, M; Nakashima, Y; Imai, T; Ichimura, M; Yamada, I; Funaba, H; Kawahata, K; Minami, T

2014-11-01

A multi-pass Thomson scattering (TS) has the advantage of enhancing scattered signals. We constructed a multi-pass TS system for a polarisation-based system and an image relaying system modelled on the GAMMA 10 TS system. We undertook Raman scattering experiments both for the multi-pass setting and for checking the optical components. Moreover, we applied the system to the electron temperature measurements in the GAMMA 10 plasma for the first time. The integrated scattering signal was magnified by approximately three times by using the multi-pass TS system with four passes. The electron temperature measurement accuracy is improved by using this multi-pass system.

High resolution phoswich gamma-ray imager utilizing monolithic MPPC arrays with submillimeter pixelized crystals

NASA Astrophysics Data System (ADS)

Kato, T.; Kataoka, J.; Nakamori, T.; Kishimoto, A.; Yamamoto, S.; Sato, K.; Ishikawa, Y.; Yamamura, K.; Kawabata, N.; Ikeda, H.; Kamada, K.

2013-05-01

We report the development of a high spatial resolution tweezers-type coincidence gamma-ray camera for medical imaging. This application consists of large-area monolithic Multi-Pixel Photon Counters (MPPCs) and submillimeter pixelized scintillator matrices. The MPPC array has 4 × 4 channels with a three-side buttable, very compact package. For typical operational gain of 7.5 × 105 at + 20 °C, gain fluctuation over the entire MPPC device is only ± 5.6%, and dark count rates (as measured at the 1 p.e. level) amount to <= 400 kcps per channel. We selected Ce-doped (Lu,Y)2(SiO4)O (Ce:LYSO) and a brand-new scintillator, Ce-doped Gd3Al2Ga3O12 (Ce:GAGG) due to their high light yield and density. To improve the spatial resolution, these scintillators were fabricated into 15 × 15 matrices of 0.5 × 0.5 mm2 pixels. The Ce:LYSO and Ce:GAGG scintillator matrices were assembled into phosphor sandwich (phoswich) detectors, and then coupled to the MPPC array along with an acrylic light guide measuring 1 mm thick, and with summing operational amplifiers that compile the signals into four position-encoded analog outputs being used for signal readout. Spatial resolution of 1.1 mm was achieved with the coincidence imaging system using a 22Na point source. These results suggest that the gamma-ray imagers offer excellent potential for applications in high spatial medical imaging.

Comparison of the imaging performances for recently developed monolithic scintillators: CRY018 and CRY019 for dual isotope gamma ray imaging applications

NASA Astrophysics Data System (ADS)

Polito, C.; Pani, R.; Trigila, C.; Cinti, M. N.; Fabbri, A.; Frantellizzi, V.; De Vincentis, G.; Pellegrini, R.; Pani, R.

2017-01-01

The growing interest for new scintillation crystals with outstanding imaging performances (i.e. resolution and efficiency) has suggested the study of recently discovered scintillators named CRY018 and CRY019. The crystals under investigation are monolithic and have shown enhanced characteristics both for gamma ray spectrometry and for Nuclear Medicine imaging applications such as the dual isotope imaging. Moreover, the non-hygroscopic nature and the absence of afterglow make these scintillators even more attractive for the potential improvement in a wide range of applications. These scintillation crystals show a high energy resolution in the energy range involved in Nuclear Medicine, allowing the discrimination between very close energy values. Moreover, in order to prove their suitability of being powerful imaging systems, the imaging performances like the position linearity and the intrinsic spatial resolution have been evaluated obtaining satisfactory results thanks to the implementation of an optimized algorithm for the images reconstruction.

Precision imaging of 4.4 MeV gamma rays using a 3-D position sensitive Compton camera.

PubMed

Koide, Ayako; Kataoka, Jun; Masuda, Takamitsu; Mochizuki, Saku; Taya, Takanori; Sueoka, Koki; Tagawa, Leo; Fujieda, Kazuya; Maruhashi, Takuya; Kurihara, Takuya; Inaniwa, Taku

2018-05-25

Imaging of nuclear gamma-ray lines in the 1-10 MeV range is far from being established in both medical and physical applications. In proton therapy, 4.4 MeV gamma rays are emitted from the excited nucleus of either 12 C* or 11 B* and are considered good indicators of dose delivery and/or range verification. Further, in gamma-ray astronomy, 4.4 MeV gamma rays are produced by cosmic ray interactions in the interstellar medium, and can thus be used to probe nucleothynthesis in the universe. In this paper, we present a high-precision image of 4.4 MeV gamma rays taken by newly developed 3-D position sensitive Compton camera (3D-PSCC). To mimic the situation in proton therapy, we first irradiated water, PMMA and Ca(OH)2 with a 70 MeV proton beam, then we identified various nuclear lines with the HPGe detector. The 4.4 MeV gamma rays constitute a broad peak, including single and double escape peaks. Thus, by setting an energy window of 3D-PSCC from 3 to 5 MeV, we show that a gamma ray image sharply concentrates near the Bragg peak, as expected from the minimum energy threshold and sharp peak profile in the cross section of 12 C(p,p) 12 C*.

Mobile, hybrid Compton/coded aperture imaging for detection, identification and localization of gamma-ray sources at stand-off distances

NASA Astrophysics Data System (ADS)

Tornga, Shawn R.

The Stand-off Radiation Detection System (SORDS) program is an Advanced Technology Demonstration (ATD) project through the Department of Homeland Security's Domestic Nuclear Detection Office (DNDO) with the goal of detection, identification and localization of weak radiological sources in the presence of large dynamic backgrounds. The Raytheon-SORDS Tri-Modal Imager (TMI) is a mobile truck-based, hybrid gamma-ray imaging system able to quickly detect, identify and localize, radiation sources at standoff distances through improved sensitivity while minimizing the false alarm rate. Reconstruction of gamma-ray sources is performed using a combination of two imaging modalities; coded aperture and Compton scatter imaging. The TMI consists of 35 sodium iodide (NaI) crystals 5x5x2 in3 each, arranged in a random coded aperture mask array (CA), followed by 30 position sensitive NaI bars each 24x2.5x3 in3 called the detection array (DA). The CA array acts as both a coded aperture mask and scattering detector for Compton events. The large-area DA array acts as a collection detector for both Compton scattered events and coded aperture events. In this thesis, developed coded aperture, Compton and hybrid imaging algorithms will be described along with their performance. It will be shown that multiple imaging modalities can be fused to improve detection sensitivity over a broader energy range than either alone. Since the TMI is a moving system, peripheral data, such as a Global Positioning System (GPS) and Inertial Navigation System (INS) must also be incorporated. A method of adapting static imaging algorithms to a moving platform has been developed. Also, algorithms were developed in parallel with detector hardware, through the use of extensive simulations performed with the Geometry and Tracking Toolkit v4 (GEANT4). Simulations have been well validated against measured data. Results of image reconstruction algorithms at various speeds and distances will be presented as well as

Advanced Laser-Compton Gamma-Ray Sources for Nuclear Materials Detection, Assay and Imaging

NASA Astrophysics Data System (ADS)

Barty, C. P. J.

2015-10-01

Highly-collimated, polarized, mono-energetic beams of tunable gamma-rays may be created via the optimized Compton scattering of pulsed lasers off of ultra-bright, relativistic electron beams. Above 2 MeV, the peak brilliance of such sources can exceed that of the world's largest synchrotrons by more than 15 orders of magnitude and can enable for the first time the efficient pursuit of nuclear science and applications with photon beams, i.e. Nuclear Photonics. Potential applications are numerous and include isotope-specific nuclear materials management, element-specific medical radiography and radiology, non-destructive, isotope-specific, material assay and imaging, precision spectroscopy of nuclear resonances and photon-induced fission. This review covers activities at the Lawrence Livermore National Laboratory related to the design and optimization of mono-energetic, laser-Compton gamma-ray systems and introduces isotope-specific nuclear materials detection and assay applications enabled by them.

TU-FG-BRB-07: GPU-Based Prompt Gamma Ray Imaging From Boron Neutron Capture Therapy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kim, S; Suh, T; Yoon, D

Purpose: The purpose of this research is to perform the fast reconstruction of a prompt gamma ray image using a graphics processing unit (GPU) computation from boron neutron capture therapy (BNCT) simulations. Methods: To evaluate the accuracy of the reconstructed image, a phantom including four boron uptake regions (BURs) was used in the simulation. After the Monte Carlo simulation of the BNCT, the modified ordered subset expectation maximization reconstruction algorithm using the GPU computation was used to reconstruct the images with fewer projections. The computation times for image reconstruction were compared between the GPU and the central processing unit (CPU).more » Also, the accuracy of the reconstructed image was evaluated by a receiver operating characteristic (ROC) curve analysis. Results: The image reconstruction time using the GPU was 196 times faster than the conventional reconstruction time using the CPU. For the four BURs, the area under curve values from the ROC curve were 0.6726 (A-region), 0.6890 (B-region), 0.7384 (C-region), and 0.8009 (D-region). Conclusion: The tomographic image using the prompt gamma ray event from the BNCT simulation was acquired using the GPU computation in order to perform a fast reconstruction during treatment. The authors verified the feasibility of the prompt gamma ray reconstruction using the GPU computation for BNCT simulations.« less

Characteristics of Gamma-Ray Loud Blazars in the VLBA Imaging and Polarimetry Survey

NASA Technical Reports Server (NTRS)

Linford, J. D.; Taylor, G. B.; Romani, R. W.; Healey, S. E.; Helmboldt, J. F.; Readhead, A. C.; Reeves, R.; Richards, J. L.; Cotter, G.

2010-01-01

The radio properties of blazars detected by the Large Area Telescope (LAT) on board the Fermi Gamma-ray Space Telescope have been observed as part of the VLBA Imaging and Polarimetry Survey. This large, flux-limited sample of active galactic nuclei (AGNs) provides insights into the mechanism that produces strong gamma-ray emission. At lower flux levels, radio flux density does not directly correlate with gamma-ray flux. We find that the LAT-detected BL Lac objects tend to be similar to the non-LAT BL Lac objects, but that the LAT-detected FSRQs are often significantly different from the non-LAT FSRQs. The differences between the gamma-ray loud and quiet FSRQS can be explained by Doppler boosting; these objects appear to require larger Doppler factors than those of the BL Lac objects. It is possible that the gamma-ray loud FSRQs are fundamentally different from the gamma-ray quiet FSRQs. Strong polarization at the base of the jet appears to be a signature for gamma-ray loud AGNs.

Tissue-equivalent TL sheet dosimetry system for X- and gamma-ray dose mapping.

PubMed

Nariyama, N; Konnai, A; Ohnishi, S; Odano, N; Yamaji, A; Ozasa, N; Ishikawa, Y

2006-01-01

To measure dose distribution for X- and gamma rays simply and accurately, a tissue-equivalent thermoluminescent (TL) sheet-type dosemeter and reader system were developed. The TL sheet is composed of LiF:Mg,Cu,P and ETFE polymer, and the thickness is 0.2 mm. For the TL reading, a square heating plate, 20 cm on each side, was developed, and the temperature distribution was measured with an infrared thermal imaging camera. As a result, linearity within 2% and the homogeneity within 3% were confirmed. The TL signal emitted is detected using a CCD camera and displayed as a spatial dose distribution. Irradiation using synchrotron radiation between 10 and 100 keV and (60)Co gamma rays showed that the TL sheet dosimetry system was promising for radiation dose mapping for various purposes.

First demonstration of aerial gamma-ray imaging using drone for prompt radiation survey in Fukushima

NASA Astrophysics Data System (ADS)

Mochizuki, S.; Kataoka, J.; Tagawa, L.; Iwamoto, Y.; Okochi, H.; Katsumi, N.; Kinno, S.; Arimoto, M.; Maruhashi, T.; Fujieda, K.; Kurihara, T.; Ohsuka, S.

2017-11-01

Considerable amounts of radioactive substances (mainly 137Cs and 134Cs) were released into the environment after the Japanese nuclear disaster in 2011. Some restrictions on residence areas were lifted in April 2017, owing to the successive and effective decontamination operations. However, the distribution of radioactive substances in vast areas of mountain, forest and satoyama close to the city is still unknown; thus, decontamination operations in such areas are being hampered. In this paper, we report on the first aerial gamma-ray imaging of a schoolyard in Fukushima using a drone that carries a high sensitivity Compton camera. We show that the distribution of 137Cs in regions with a diameter of several tens to a hundred meters can be imaged with a typical resolution of 2-5 m within a 10-20 min flights duration. The aerial gamma-ray images taken 10 m and 20 m above the ground are qualitatively consistent with a dose map reconstructed from the ground-based measurements using a survey meter. Although further quantification is needed for the distance and air-absorption corrections to derive in situ dose map, such an aerial drone system can reduce measurement time by a factor of ten and is suitable for place where ground-based measurement are difficult.

Adaptive gamma correction-based expert system for nonuniform illumination face enhancement

NASA Astrophysics Data System (ADS)

Abdelhamid, Iratni; Mustapha, Aouache; Adel, Oulefki

2018-03-01

The image quality of a face recognition system suffers under severe lighting conditions. Thus, this study aims to develop an approach for nonuniform illumination adjustment based on an adaptive gamma correction (AdaptGC) filter that can solve the aforementioned issue. An approach for adaptive gain factor prediction was developed via neural network model-based cross-validation (NN-CV). To achieve this objective, a gamma correction function and its effects on the face image quality with different gain values were examined first. Second, an orientation histogram (OH) algorithm was assessed as a face's feature descriptor. Subsequently, a density histogram module was developed for face label generation. During the NN-CV construction, the model was assessed to recognize the OH descriptor and predict the face label. The performance of the NN-CV model was evaluated by examining the statistical measures of root mean square error and coefficient of efficiency. Third, to evaluate the AdaptGC enhancement approach, an image quality metric was adopted using enhancement by entropy, contrast per pixel, second-derivative-like measure of enhancement, and sharpness, then supported by visual inspection. The experiment results were examined using five face's databases, namely, extended Yale-B, Carnegie Mellon University-Pose, Illumination, and Expression, Mobio, FERET, and Oulu-CASIA-NIR-VIS. The final results prove that AdaptGC filter implementation compared with state-of-the-art methods is the best choice in terms of contrast and nonuniform illumination adjustment. In summary, the benefits attained prove that AdaptGC is driven by a profitable enhancement rate, which provides satisfying features for high rate face recognition systems.

Coded-aperture imaging of the Galactic center region at gamma-ray energies

NASA Technical Reports Server (NTRS)

Cook, Walter R.; Grunsfeld, John M.; Heindl, William A.; Palmer, David M.; Prince, Thomas A.

1991-01-01

The first coded-aperture images of the Galactic center region at energies above 30 keV have revealed two strong gamma-ray sources. One source has been identified with the X-ray source IE 1740.7 - 2942, located 0.8 deg away from the nucleus. If this source is at the distance of the Galactic center, it is one of the most luminous objects in the galaxy at energies from 35 to 200 keV. The second source is consistent in location with the X-ray source GX 354 + 0 (MXB 1728-34). In addition, gamma-ray flux from the location of GX 1 + 4 was marginally detected at a level consistent with other post-1980 measurements. No significant hard X-ray or gamma-ray flux was detected from the direction of the Galactic nucleus or from the direction of the recently discovered gamma-ray source GRS 1758-258.

Electro-optical imaging systems integration

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wight, R.

1987-01-01

Since the advent of high resolution, high data rate electronic sensors for military aircraft, the demands on their counterpart, the image generator hard copy output system, have increased dramatically. This has included support of direct overflight and standoff reconnaissance systems and often has required operation within a military shelter or van. The Tactical Laser Beam Recorder (TLBR) design has met the challenge each time. A third generation (TLBR) was designed and two units delivered to rapidly produce high quality wet process imagery on 5-inch film from a 5-sensor digital image signal input. A modular, in-line wet film processor is includedmore » in the total TLBR (W) system. The system features a rugged optical and transport package that requires virtually no alignment or maintenance. It has a ''Scan FIX'' capability which corrects for scanner fault errors and ''Scan LOC'' system which provides for complete phase synchronism isolation between scanner and digital image data input via strobed, 2-line digital buffers. Electronic gamma adjustment automatically compensates for variable film processing time as the film speed changes to track the sensor. This paper describes the fourth meeting of that challenge, the High Resolution Laser Beam Recorder (HRLBR) for Reconnaissance/Tactical applications.« less

Fiber fed x-ray/gamma ray imaging apparatus

DOEpatents

Hailey, C.J.; Ziock, K.P.

1992-06-02

X-ray/gamma ray imaging apparatus is disclosed for detecting the position, energy, and intensity of x-ray/gamma ray radiation comprising scintillation means disposed in the path of such radiation and capable of generating photons in response to such radiation; first photodetection means optically bonded to the scintillation means and capable of generating an electrical signal indicative of the intensity, and energy of the radiation detected by the scintillation means; second photodetection means capable of generating an electrical signal indicative of the position of the radiation in the radiation pattern; and means for optically coupling the scintillation means to the second photodetection means. The photodetection means are electrically connected to control and storage means which may also be used to screen out noise by rejecting a signal from one photodetection means not synchronized to a signal from the other photodetection means; and also to screen out signals from scattered radiation. 6 figs.

SU-E-J-240: The Impact On Clinical Dose-Distributions When Using MR-Images Registered with Stereotactic CT-Images in Gamma Knife Radiosurgery

DOE Office of Scientific and Technical Information (OSTI.GOV)

Benmakhlouf, H; Kraepelien, T; Forander, P

2014-06-01

Purpose: Most Gamma knife treatments are based solely on MR-images. However, for fractionated treatments and to implement TPS dose calculations that require electron densities, CT image data is essential. The purpose of this work is to assess the dosimetric effects of using MR-images registered with stereotactic CT-images in Gamma knife treatments. Methods: Twelve patients treated for vestibular schwannoma with Gamma Knife Perfexion (Elekta Instruments, Sweden) were selected for this study. The prescribed doses (12 Gy to periphery) were delivered based on the conventional approach of using stereotactic MR-images only. These plans were imported into stereotactic CT-images (by registering MR-images withmore » stereotactic CT-images using the Leksell gamma plan registration software). The dose plans, for each patient, are identical in both cases except for potential rotations and translations resulting from the registration. The impact of the registrations was assessed by an algorithm written in Matlab. The algorithm compares the dose-distributions voxel-by-voxel between the two plans, calculates the full dose coverage of the target (treated in the conventional approach) achieved by the CT-based plan, and calculates the minimum dose delivered to the target (treated in the conventional approach) achieved by the CT-based plan. Results: The mean dose difference between the plans was 0.2 Gy to 0.4 Gy (max 4.5 Gy) whereas between 89% and 97% of the target (treated in the conventional approach) received the prescribed dose, by the CT-plan. The minimum dose to the target (treated in the conventional approach) given by the CT-based plan was between 7.9 Gy and 10.7 Gy (compared to 12 Gy in the conventional treatment). Conclusion: The impact of using MR-images registered with stereotactic CT-images has successfully been compared to conventionally delivered dose plans showing significant differences between the two. Although CTimages have been implemented clinically; the

A novel fully integrated handheld gamma camera

NASA Astrophysics Data System (ADS)

Massari, R.; Ucci, A.; Campisi, C.; Scopinaro, F.; Soluri, A.

2016-10-01

In this paper, we present an innovative, fully integrated handheld gamma camera, namely designed to gather in the same device the gamma ray detector with the display and the embedded computing system. The low power consumption allows the prototype to be battery operated. To be useful in radioguided surgery, an intraoperative gamma camera must be very easy to handle since it must be moved to find a suitable view. Consequently, we have developed the first prototype of a fully integrated, compact and lightweight gamma camera for radiopharmaceuticals fast imaging. The device can operate without cables across the sterile field, so it may be easily used in the operating theater for radioguided surgery. The prototype proposed consists of a Silicon Photomultiplier (SiPM) array coupled with a proprietary scintillation structure based on CsI(Tl) crystals. To read the SiPM output signals, we have developed a very low power readout electronics and a dedicated analog to digital conversion system. One of the most critical aspects we faced designing the prototype was the low power consumption, which is mandatory to develop a battery operated device. We have applied this detection device in the lymphoscintigraphy technique (sentinel lymph node mapping) comparing the results obtained with those of a commercial gamma camera (Philips SKYLight). The results obtained confirm a rapid response of the device and an adequate spatial resolution for the use in the scintigraphic imaging. This work confirms the feasibility of a small gamma camera with an integrated display. This device is designed for radioguided surgery and small organ imaging, but it could be easily combined into surgical navigation systems.

A restraint-free small animal SPECT imaging system with motion tracking

DOE Office of Scientific and Technical Information (OSTI.GOV)

Weisenberger, A.G.; Gleason, S.S.; Goddard, J.

2005-06-01

We report on an approach toward the development of a high-resolution single photon emission computed tomography (SPECT) system to image the biodistribution of radiolabeled tracers such as Tc-99m and I-125 in unrestrained/unanesthetized mice. An infrared (IR)-based position tracking apparatus has been developed and integrated into a SPECT gantry. The tracking system is designed to measure the spatial position of a mouse's head at a rate of 10-15 frames per second with submillimeter accuracy. The high-resolution, gamma imaging detectors are based on pixellated NaI(Tl) crystal scintillator arrays, position-sensitive photomultiplier tubes, and novel readout circuitry requiring fewer analog-digital converter (ADC) channels whilemore » retaining high spatial resolution. Two SPECT gamma camera detector heads based upon position-sensitive photomultiplier tubes have been built and installed onto the gantry. The IR landmark-based pose measurement and tracking system is under development to provide animal position data during a SPECT scan. The animal position and orientation data acquired by the tracking system will be used for motion correction during the tomographic image reconstruction.« less

A Mobile Automated Tomographic Gamma Scanning System - 13231

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kirkpatrick, J.M.; LeBlanc, P.J.; Nakazawa, D.

2013-07-01

Canberra Industries have recently designed and built a new automated Tomographic Gamma Scanning (TGS) system for mobile deployment. The TGS technique combines high-resolution gamma spectroscopy with low spatial resolution 3-dimensional image reconstruction to provide increased accuracy over traditional approaches for the assay of non-uniform source distributions in low-to medium-density, non-heterogeneous matrices. Originally pioneered by R. Estep at Los Alamos National Laboratory (LANL), the TGS method has been further developed and commercialized by Canberra Industries in recent years. The present system advances the state of the art on several fronts: it is designed to be housed in a standard cargo transportmore » container for ease of transport, allowing waste characterization at multiple facilities under the purview of a single operator. Conveyor feed, drum rotator, and detector and collimator positioning mechanisms operated by programmable logic control (PLC) allow automated batch mode operation. The variable geometry settings can accommodate a wide range of waste packaging, including but not limited to standard 220 liter drums, 380 liter overpack drums, and smaller 20 liter cans. A 20 mCi Eu-152 transmission source provides attenuation corrections for drum matrices up to 1 g/cm{sup 3} in TGS mode; the system can be operated in Segmented Gamma Scanning (SGS) mode to measure higher density drums. To support TGS assays at higher densities, the source shield is sufficient to house an alternate Co-60 transmission source of higher activity, up to 250 mCi. An automated shutter and attenuator assembly is provided for operating the system with a dual intensity transmission source. The system's 1500 kg capacity rotator turntable can handle heavy containers such as concrete lined 380 liter overpack drums. Finally, data acquisition utilizes Canberra's Broad Energy Germanium (BEGE) detector and Lynx MCA, with 32 k channels, providing better than 0.1 ke

GRI: The Gamma-Ray Imager mission

NASA Astrophysics Data System (ADS)

Knödlseder, J.; Gri Consortium

Observations of the gamma-ray sky reveal the most powerful sources and the most violent events in the Universe While at lower wavebands the observed emission is generally dominated by thermal processes the gamma-ray sky provides us with a view on the non-thermal Universe Here particles are accelerated to extreme relativistic energies by mechanisms which are still poorly understood and nuclear reactions are synthesizing the basic constituents of our world Cosmic accelerators and cosmic explosions are the major science themes that are addressed in the gamma-ray regime With the INTEGRAL observatory ESA has provided a unique tool to the astronomical community and has put Europe in the lead in the field of gamma-ray astronomy INTEGRAL provides an unprecedented survey of the soft gamma-ray sky revealing hundreds of sources new classes of objects extraordinary views of antimatter annihilation in our Galaxy and fingerprints of recent nucleosynthesis processes While INTEGRAL has provided the global overview over the soft gamma-ray sky there is a growing need to perform deeper more focused investigations of gamma-ray sources In soft X-rays a comparable step was taken going from the Einstein satellite to the XMM Newton observatory Technological advances in the past years in the domain of gamma-ray focusing using Laue diffraction and multilayer-coated mirror techniques have paved the way towards a gamma-ray mission providing major improvements compared to past missions regarding sensitivity and angular resolution Such a

A liquid xenon imaging telescope for 1-30 MeV gamma-ray astrophysics

NASA Technical Reports Server (NTRS)

Aprile, Elena; Mukherjee, Reshmi; Suzuki, Masayo

1989-01-01

A study of the primary scintillation light in liquid xenon excited by 241 Am alpha particles and 207 Bi internal conversion electrons are discussed. The time dependence and the intensity of the light at different field strengths have been measured with a specifically designed chamber, equipped with a CaF sub 2 light transmitting window coupled to a UV sensitive PMT. The time correlation between the fast light signal and the charge signal shows that the scintillation signals produced in liquid xenon by ionizing particles provides an ideal trigger in a Time Projection type LXe detector aiming at full imaging of complex gamma-ray events. Researchers also started Monte Carlo calculations to establish the performance of a LXe imaging telescope for high energy gamma-rays.

Progress towards a semiconductor Compton camera for prompt gamma imaging during proton beam therapy for range and dose verification

NASA Astrophysics Data System (ADS)

Gutierrez, A.; Baker, C.; Boston, H.; Chung, S.; Judson, D. S.; Kacperek, A.; Le Crom, B.; Moss, R.; Royle, G.; Speller, R.; Boston, A. J.

2018-01-01

The main objective of this work is to test a new semiconductor Compton camera for prompt gamma imaging. Our device is composed of three active layers: a Si(Li) detector as a scatterer and two high purity Germanium detectors as absorbers of high-energy gamma rays. We performed Monte Carlo simulations using the Geant4 toolkit to characterise the expected gamma field during proton beam therapy and have made experimental measurements of the gamma spectrum with a 60 MeV passive scattering beam irradiating a phantom. In this proceeding, we describe the status of the Compton camera and present the first preliminary measurements with radioactive sources and their corresponding reconstructed images.

Time encoded radiation imaging

DOEpatents

Marleau, Peter; Brubaker, Erik; Kiff, Scott

2014-10-21

The various technologies presented herein relate to detecting nuclear material at a large stand-off distance. An imaging system is presented which can detect nuclear material by utilizing time encoded imaging relating to maximum and minimum radiation particle counts rates. The imaging system is integrated with a data acquisition system that can utilize variations in photon pulse shape to discriminate between neutron and gamma-ray interactions. Modulation in the detected neutron count rates as a function of the angular orientation of the detector due to attenuation of neighboring detectors is utilized to reconstruct the neutron source distribution over 360 degrees around the imaging system. Neutrons (e.g., fast neutrons) and/or gamma-rays are incident upon scintillation material in the imager, the photons generated by the scintillation material are converted to electrical energy from which the respective neutrons/gamma rays can be determined and, accordingly, a direction to, and the location of, a radiation source identified.

Determination of in vivo behavior of mitomycin C-loaded o/w soybean oil microemulsion and mitomycin C solution via gamma camera imaging.

PubMed

Kotmakçı, Mustafa; Kantarcı, Gülten; Aşıkoğlu, Makbule; Ozkılıç, Hayal; Ertan, Gökhan

2013-09-01

In this study, a microemulsion system was evaluated for delivery of mitomycin C (MMC). To track the distribution of the formulated drug after intravenous administration, radiochemical labeling and gamma scintigraphy imaging were used. The aim was to evaluate a microemulsion system for intravenous delivery of MMC and to compare its in vivo behavior with that of the MMC solution. For microemulsion formulation, soybean oil was used as the oil phase. Lecithin and Tween 80 were surfactants and ethanol was the cosurfactant. To understand the whole body localization of MMC-loaded microemulsion, MMC was labeled with radioactive technetium and gamma scintigraphy was applied for visualization of drug distribution. Radioactivity in the bladder 30 minutes after injection of the MMC solution was observed, according to static gamma camera images. This shows that urinary excretion of the latter starts very soon. On the other hand, no radioactivity appeared in the urinary bladder during the 90 minutes following the administration of MMC-loaded microemulsion. The unabated radioactivity in the liver during the experiment shows that the localization of microemulsion formulation in the liver is stable. In the light of the foregoing, it is suggested that this microemulsion formulation may be an appropriate carrier system for anticancer agents by intravenous delivery in hepatic cancer chemotherapy.

PSF reconstruction for Compton-based prompt gamma imaging

NASA Astrophysics Data System (ADS)

Jan, Meei-Ling; Lee, Ming-Wei; Huang, Hsuan-Ming

2018-02-01

Compton-based prompt gamma (PG) imaging has been proposed for in vivo range verification in proton therapy. However, several factors degrade the image quality of PG images, some of which are due to inherent properties of a Compton camera such as spatial resolution and energy resolution. Moreover, Compton-based PG imaging has a spatially variant resolution loss. In this study, we investigate the performance of the list-mode ordered subset expectation maximization algorithm with a shift-variant point spread function (LM-OSEM-SV-PSF) model. We also evaluate how well the PG images reconstructed using an SV-PSF model reproduce the distal falloff of the proton beam. The SV-PSF parameters were estimated from simulation data of point sources at various positions. Simulated PGs were produced in a water phantom irradiated with a proton beam. Compared to the LM-OSEM algorithm, the LM-OSEM-SV-PSF algorithm improved the quality of the reconstructed PG images and the estimation of PG falloff positions. In addition, the 4.44 and 5.25 MeV PG emissions can be accurately reconstructed using the LM-OSEM-SV-PSF algorithm. However, for the 2.31 and 6.13 MeV PG emissions, the LM-OSEM-SV-PSF reconstruction provides limited improvement. We also found that the LM-OSEM algorithm followed by a shift-variant Richardson-Lucy deconvolution could reconstruct images with quality visually similar to the LM-OSEM-SV-PSF-reconstructed images, while requiring shorter computation time.

Initial results from a multiple monoenergetic gamma radiography system for nuclear security

NASA Astrophysics Data System (ADS)

O'Day, Buckley E.; Hartwig, Zachary S.; Lanza, Richard C.; Danagoulian, Areg

2016-10-01

The detection of assembled nuclear devices and concealed special nuclear materials (SNM) such as plutonium or uranium in commercial cargo traffic is a major challenge in mitigating the threat of nuclear terrorism. Currently available radiographic and active interrogation systems use ∼1-10 MeV bremsstrahlung photon beams. Although simple to build and operate, bremsstrahlung-based systems deliver high radiation doses to the cargo and to potential stowaways. To eliminate problematic issues of high dose, we are developing a novel technique known as multiple monoenergetic gamma radiography (MMGR). MMGR uses ion-induced nuclear reactions to produce two monoenergetic gammas for dual-energy radiography. This allows us to image the areal density and effective atomic number (Zeff) of scanned cargo. We present initial results from the proof-of-concept experiment, which was conducted at the MIT Bates Research and Engineering Center. The purpose of the experiment was to assess the capabilities of MMGR to measure areal density and Zeff of container cargo mockups. The experiment used a 3.0 MeV radiofrequency quadrupole accelerator to create sources of 4.44 MeV and 15.11 MeV gammas from the 11B(d,nγ)12C reaction in a thick natural boron target; the gammas are detected by an array of NaI(Tl) detectors after transmission through cargo mockups . The measured fluxes of transmitted 4.44 MeV and 15.11 MeV gammas were used to assess the areal density and Zeff. Initial results show that MMGR is capable of discriminating the presence of high-Z materials concealed in up to 30 cm of iron shielding from low- and mid-Z materials present in the cargo mockup.

A novel liquid-Xenon detector concept for combined fast-neutrons and gamma imaging and spectroscopy

NASA Astrophysics Data System (ADS)

Breskin, A.; Israelashvili, I.; Cortesi, M.; Arazi, L.; Shchemelinin, S.; Chechik, R.; Dangendorf, V.; Bromberger, B.; Vartsky, D.

2012-06-01

A new detector concept is presented for combined imaging and spectroscopy of fast-neutrons and gamma rays. It comprises a liquid-Xenon (LXe) converter and scintillator coupled to a UV-sensitive gaseous imaging photomultiplier (GPM). Radiation imaging is obtained by localization of the scintillation-light from LXe with the position-sensitive GPM. The latter comprises a cascade of Thick Gas Electron Multipliers (THGEM), where the first element is coated with a CsI UV-photocathode. We present the concept and provide first model-simulation results of the processes involved and the expected performances of a detector having a LXe-filled capillaries converter. The new detector concept has potential applications in combined fast-neutron and gamma-ray screening of hidden explosives and fissile materials with pulsed sources.

SU-F-T-236: Comparison of Two IMRT/VMAT QA Systems Using Gamma Index Analysis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dogan, N; Denissova, S

2016-06-15

Purpose: The goal of this study is to assess differences in the Gamma index pass rates when using two commercial QA systems and provide optimum Gamma index parameters for pre-treatment patient specific QA. Methods: Twenty-two VMAT cases that consisted of prostate, lung, head and neck, spine, brain and pancreas, were included in this study. The verification plans have been calculated using AcurosXB(V11) algorithm for different dose grids (1.5mm, 2.5mm, 3mm). The measurements were performed on TrueBeam(Varian) accelerator using both EPID(S1000) portal imager and ArcCheck(SunNuclearCorp) devices. Gamma index criteria variation of 3%/3mm, 2%/3mm, 2%/2mm and threshold (TH) doses of 5% tomore » 50% were used in analysis. Results: The differences in Gamma pass rates between two devices are not statistically significant for 3%/3mm, yielding pass rate higher than 95%. Increase of lower dose TH showed reduced pass rates for both devices. ArcCheck’s more pronounced effect can be attributed to higher contribution of lower dose region spread. As expected, tightening criteria to 2%/2mm (TH: 10%) decreased Gamma pass rates below 95%. Higher EPID (92%) pass rates compared to ArcCheck (86%) probably due to better spatial resolution. Portal Dosimetry results showed lower Gamma pass rates for composite plans compared to individual field pass rates. This may be due to the expansion in the analyzed region which includes pixels not included in the separate field analysis. Decreasing dose grid size from 2.5mm to 1.5mm did not show statistically significant (p<0.05) differences in Gamma pass rates for both QA devices. Conclusion: Overall, both system measurements agree well with calculated dose when using gamma index criteria of 3%/3mm for a variety of VMAT cases. Variability between two systems increases using different dose GRID, TH and tighter gamma criteria and must be carefully assessed prior to clinical use.« less

Regional SAR Image Segmentation Based on Fuzzy Clustering with Gamma Mixture Model

NASA Astrophysics Data System (ADS)

Li, X. L.; Zhao, Q. H.; Li, Y.

2017-09-01

Most of stochastic based fuzzy clustering algorithms are pixel-based, which can not effectively overcome the inherent speckle noise in SAR images. In order to deal with the problem, a regional SAR image segmentation algorithm based on fuzzy clustering with Gamma mixture model is proposed in this paper. First, initialize some generating points randomly on the image, the image domain is divided into many sub-regions using Voronoi tessellation technique. Each sub-region is regarded as a homogeneous area in which the pixels share the same cluster label. Then, assume the probability of the pixel to be a Gamma mixture model with the parameters respecting to the cluster which the pixel belongs to. The negative logarithm of the probability represents the dissimilarity measure between the pixel and the cluster. The regional dissimilarity measure of one sub-region is defined as the sum of the measures of pixels in the region. Furthermore, the Markov Random Field (MRF) model is extended from pixels level to Voronoi sub-regions, and then the regional objective function is established under the framework of fuzzy clustering. The optimal segmentation results can be obtained by the solution of model parameters and generating points. Finally, the effectiveness of the proposed algorithm can be proved by the qualitative and quantitative analysis from the segmentation results of the simulated and real SAR images.

SU-E-T-335: Dosimetric Investigation of An Advanced Rotating Gamma Ray System for Imaged Guided Radiation Therapy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ma, C; Eldib, A; Chibani, O

2015-06-15

Purpose: Co-60 beams have unique dosimetric properties for cranial treatments and thoracic cancers. The conventional concern about the high surface dose is overcome by modern system designs with rotational treatment techniques. This work investigates a novel rotational Gamma ray system for image-guided, external beam radiotherapy. Methods: The CybeRT system (Cyber Medical Corp., China) consists of a ring gantry with either one or two treatment heads containing a Gamma source and a multileaf collimator (MLC). The MLC has 60 paired leaves, and the maximum field size is either 40cmx40cm (40 pairs of 0.5cm central leaves, 20 pairs of 1cm outer leaves),more » or 22cmx40cm (32 pairs of 0.25cm central leaves, 28 pairs of 0.5cm outer leaves). The treatment head(s) can swing 35° superiorly and 8° inferiorly, allowing a total of 43° non-coplanar beam incident. The treatment couch provides 6-degrees-of-freedom motion compensation and the kV cone-beam CT system has a spatial resolution of 0.4mm. Monte Carlo simulations were used to compute dose distributions and compare with measurements. A retrospective study of 98 previously treated patients was performed to compare CybeRT with existing RT systems. Results: Monte Carlo results confirmed the CybeRT design parameters including output factors and 3D dose distributions. Its beam penumbra/dose gradient was similar to or better than that of 6MV photon beams and its isocenter accuracy is 0.3mm. Co-60 beams produce lower-energy secondary electrons that exhibit better dose properties in low-density lung tissues. Because of their rapid depth dose falloff, Co-60 beams are favorable for peripheral lung tumors with half-arc arrangements to spare the opposite lung and critical structures. Superior dose distributions were obtained for head and neck, breast, spine and lung tumors. Conclusion: Because of its accurate dose delivery and unique dosimetric properties of C-60 sources, CybeRT is ideally suited for advanced SBRT as well as

Imaging the Crab nebula when it is flaring in gamma-rays

NASA Astrophysics Data System (ADS)

De Luca, Andrea

2012-10-01

One of the most intriguing results of the gamma-ray instruments currently in orbit has been the detection of powerful flares from the Crab Nebula in September 2010. In April 2011 a similar flare, lasting several days, made the nebula the brightest source in the gamma-ray sky. A critical reassessment of long term behavior of the Crab flux clearly showed that both Agile and Fermi had already detected similar events in October 2007 and February 2009, pointing to a recurrence time of once per year. A HST observing strategy must be set up to react promptly to any possible new brightening of the Crab in gamma rays. In September 2010 we requested a DD observation which was promptly accepted and carried out. However, the lack of a suitable reference image hampered our efforts to pinpoint the sites of possible variability inside the nebula. Thus, while now we ask for a triggered TOO observation of the Crab Nebula with ACS/WFC in case a gamma-ray flare is announced by the Agile and/or Fermi missions, we are also organizing a regular {monthly} monitoring of the source both in X-ray and optical through a joint Chandra-HST proposal.

A SPECT Scanner for Rodent Imaging Based on Small-Area Gamma Cameras

NASA Astrophysics Data System (ADS)

Lage, Eduardo; Villena, José L.; Tapias, Gustavo; Martinez, Naira P.; Soto-Montenegro, Maria L.; Abella, Mónica; Sisniega, Alejandro; Pino, Francisco; Ros, Domènec; Pavia, Javier; Desco, Manuel; Vaquero, Juan J.

2010-10-01

We developed a cost-effective SPECT scanner prototype (rSPECT) for in vivo imaging of rodents based on small-area gamma cameras. Each detector consists of a position-sensitive photomultiplier tube (PS-PMT) coupled to a 30 x 30 Nal(Tl) scintillator array and electronics attached to the PS-PMT sockets for adapting the detector signals to an in-house developed data acquisition system. The detector components are enclosed in a lead-shielded case with a receptacle to insert the collimators. System performance was assessed using 99mTc for a high-resolution parallel-hole collimator, and for a 0.75-mm pinhole collimator with a 60° aperture angle and a 42-mm collimator length. The energy resolution is about 10.7% of the photopeak energy. The overall system sensitivity is about 3 cps/μCi/detector and planar spatial resolution ranges from 2.4 mm at 1 cm source-to-collimator distance to 4.1 mm at 4.5 cm with parallel-hole collimators. With pinhole collimators planar spatial resolution ranges from 1.2 mm at 1 cm source-to-collimator distance to 2.4 mm at 4.5 cm; sensitivity at these distances ranges from 2.8 to 0.5 cps/μCi/detector. Tomographic hot-rod phantom images are presented together with images of bone, myocardium and brain of living rodents to demonstrate the feasibility of preclinical small-animal studies with the rSPECT.

Evaluation of a CdTe semiconductor based compact gamma camera for sentinel lymph node imaging

DOE Office of Scientific and Technical Information (OSTI.GOV)

Russo, Paolo; Curion, Assunta S.; Mettivier, Giovanni

2011-03-15

Purpose: The authors assembled a prototype compact gamma-ray imaging probe (MediPROBE) for sentinel lymph node (SLN) localization. This probe is based on a semiconductor pixel detector. Its basic performance was assessed in the laboratory and clinically in comparison with a conventional gamma camera. Methods: The room-temperature CdTe pixel detector (1 mm thick) has 256x256 square pixels arranged with a 55 {mu}m pitch (sensitive area 14.08x14.08 mm{sup 2}), coupled pixel-by-pixel via bump-bonding to the Medipix2 photon-counting readout CMOS integrated circuit. The imaging probe is equipped with a set of three interchangeable knife-edge pinhole collimators (0.94, 1.2, or 2.1 mm effective diametermore » at 140 keV) and its focal distance can be regulated in order to set a given field of view (FOV). A typical FOV of 70 mm at 50 mm skin-to-collimator distance corresponds to a minification factor 1:5. The detector is operated at a single low-energy threshold of about 20 keV. Results: For {sup 99m}Tc, at 50 mm distance, a background-subtracted sensitivity of 6.5x10{sup -3} cps/kBq and a system spatial resolution of 5.5 mm FWHM were obtained for the 0.94 mm pinhole; corresponding values for the 2.1 mm pinhole were 3.3x10{sup -2} cps/kBq and 12.6 mm. The dark count rate was 0.71 cps. Clinical images in three patients with melanoma indicate detection of the SLNs with acquisition times between 60 and 410 s with an injected activity of 26 MBq {sup 99m}Tc and prior localization with standard gamma camera lymphoscintigraphy. Conclusions: The laboratory performance of this imaging probe is limited by the pinhole collimator performance and the necessity of working in minification due to the limited detector size. However, in clinical operative conditions, the CdTe imaging probe was effective in detecting SLNs with adequate resolution and an acceptable sensitivity. Sensitivity is expected to improve with the future availability of a larger CdTe detector permitting operation at

131I activity quantification of gamma camera planar images.

PubMed

Barquero, Raquel; Garcia, Hugo P; Incio, Monica G; Minguez, Pablo; Cardenas, Alexander; Martínez, Daniel; Lassmann, Michael

2017-02-07

A procedure to estimate the activity in target tissues in patients during the therapeutic administration of 131 I radiopharmaceutical treatment for thyroid conditions (hyperthyroidism and differentiated thyroid cancer) using a gamma camera (GC) with a high energy (HE) collimator, is proposed. Planar images are acquired for lesions of different sizes r, and at different distances d, in two HE GC systems. Defining a region of interest (ROI) on the image of size r, total counts n g are measured. Sensitivity S (cps MBq -1 ) in each acquisition is estimated as the product of the geometric G and the intrinsic efficiency η 0 . The mean fluence of 364 keV photons arriving at the ROI per disintegration G, is calculated with the MCNPX code, simulating the entire GC and the HE collimator. Intrinsic efficiency η 0 is estimated from a calibration measurement of a plane reference source of 131 I in air. Values of G and S for two GC systems-Philips Skylight and Siemens e-cam-are calculated. The total range of possible sensitivity values in thyroidal imaging in the e-cam and skylight GC measure from 7 cps MBq -1 to 35 cps MBq -1 , and from 6 cps MBq -1 to 29 cps MBq -1 , respectively. These sensitivity values have been verified with the SIMIND code, with good agreement between them. The results have been validated with experimental measurements in air, and in a medium with scatter and attenuation. The counts in the ROI can be produced by direct, scatter and penetration photons. The fluence value for direct photons is constant for any r and d values, but scatter and penetration photons show different values related to specific r and d values, resulting in the large sensitivity differences found. The sensitivity in thyroidal GC planar imaging is strongly dependent on uptake size, and distance from the GC. An individual value for the acquisition sensitivity of each lesion can significantly alleviate the level of uncertainty in the measurement of thyroid uptake activity for each

A balloon-borne payload for imaging hard X-rays and gamma rays from solar flares

NASA Technical Reports Server (NTRS)

Crannell, Carol J.; Dennis, Brian R.; Orwig, Larry E.; Schmahl, Edward J.; Lang, Frederic L.; Starr, Richard; Norris, Jay P.; Greene, Michael E.; Hurford, Gordon J.; Johnson, W. N.

1991-01-01

Hard X-rays and gamma rays provide direct evidence of the roles of accelerated particles in solar flares. An approach that employs a spatial Fourier-transform technique for imaging the sources of these emissions is described, and the development of a balloon-borne imaging device based on this instrumental technique is presented. The detectors, together with the imaging optics, are sensitive to hard X-ray and gamma-ray emission in the energy-range from 20 to 700 keV. This payload, scheduled for its first flight in June 1992, will provide 11-arc second angular resolution and millisecond time resolution with a whole-sun field of view. For subsequent flights, the effective detector area can be increased by as much as a factor of four, and imaging optics with angular resolution as fine as 2 arcsec can be added to the existing gondola and metering structures.

Design of optimal collimation for dedicated molecular breast imaging systems

DOE Office of Scientific and Technical Information (OSTI.GOV)

Weinmann, Amanda L.; Hruska, Carrie B.; O'Connor, Michael K.

2009-03-15

Molecular breast imaging (MBI) is a functional imaging technique that uses specialized small field-of-view gamma cameras to detect the preferential uptake of a radiotracer in breast lesions. MBI has potential to be a useful adjunct method to screening mammography for the detection of occult breast cancer. However, a current limitation of MBI is the high radiation dose (a factor of 7-10 times that of screening mammography) associated with current technology. The purpose of this study was to optimize the gamma camera collimation with the aim of improving sensitivity while retaining adequate resolution for the detection of sub-10-mm lesions. Square-hole collimatorsmore » with holes matched to the pixilated cadmium zinc telluride detector elements of the MBI system were designed. Data from MBI patient studies and parameters of existing dual-head MBI systems were used to guide the range of desired collimator resolutions, source-to-collimator distances, pixel sizes, and collimator materials that were examined. General equations describing collimator performance for a conventional gamma camera were used in the design process along with several important adjustments to account for the specialized imaging geometry of the MBI system. Both theoretical calculations and a Monte Carlo model were used to measure the geometric efficiency (or sensitivity) and resolution of each designed collimator. Results showed that through optimal collimation, collimator sensitivity could be improved by factors of 1.5-3.2, while maintaining a collimator resolution of either {<=}5 or {<=}7.5 mm at a distance of 3 cm from the collimator face. These gains in collimator sensitivity permit an inversely proportional drop in the required dose to perform MBI.« less

A data acquisition and control system for high-speed gamma-ray tomography

NASA Astrophysics Data System (ADS)

Hjertaker, B. T.; Maad, R.; Schuster, E.; Almås, O. A.; Johansen, G. A.

2008-09-01

A data acquisition and control system (DACS) for high-speed gamma-ray tomography based on the USB (Universal Serial Bus) and Ethernet communication protocols has been designed and implemented. The high-speed gamma-ray tomograph comprises five 500 mCi 241Am gamma-ray sources, each at a principal energy of 59.5 keV, which corresponds to five detector modules, each consisting of 17 CdZnTe detectors. The DACS design is based on Microchip's PIC18F4550 and PIC18F4620 microcontrollers, which facilitates an USB 2.0 interface protocol and an Ethernet (IEEE 802.3) interface protocol, respectively. By implementing the USB- and Ethernet-based DACS, a sufficiently high data acquisition rate is obtained and no dedicated hardware installation is required for the data acquisition computer, assuming that it is already equipped with a standard USB and/or Ethernet port. The API (Application Programming Interface) for the DACS is founded on the National Instrument's LabVIEW® graphical development tool, which provides a simple and robust foundation for further application software developments for the tomograph. The data acquisition interval, i.e. the integration time, of the high-speed gamma-ray tomograph is user selectable and is a function of the statistical measurement accuracy required for the specific application. The bandwidth of the DACS is 85 kBytes s-1 for the USB communication protocol and 28 kBytes s-1 for the Ethernet protocol. When using the iterative least square technique reconstruction algorithm with a 1 ms integration time, the USB-based DACS provides an online image update rate of 38 Hz, i.e. 38 frames per second, whereas 31 Hz for the Ethernet-based DACS. The off-line image update rate (storage to disk) for the USB-based DACS is 278 Hz using a 1 ms integration time. Initial characterization of the high-speed gamma-ray tomograph using the DACS on polypropylene phantoms is presented in the paper.

The structure, logic of operation and distinctive features of the system of triggers and counting signals formation for gamma-telescope GAMMA-400

NASA Astrophysics Data System (ADS)

Topchiev, N. P.; Galper, A. M.; Arkhangelskiy, A. I.; Arkhangelskaja, I. V.; Kheymits, M. D.; Suchkov, S. I.; Yurkin, Y. T.

2017-01-01

Scientific project GAMMA-400 (Gamma Astronomical Multifunctional Modular Apparatus) relates to the new generation of space observatories intended to perform an indirect search for signatures of dark matter in the cosmic-ray fluxes, measurements of characteristics of diffuse gamma-ray emission and gamma-rays from the Sun during periods of solar activity, gamma-ray bursts, extended and point gamma-ray sources, electron/positron and cosmic-ray nuclei fluxes up to TeV energy region by means of the GAMMA-400 gamma-ray telescope represents the core of the scientific complex. The system of triggers and counting signals formation of the GAMMA-400 gamma-ray telescope constitutes the pipelined processor structure which collects data from the gamma-ray telescope subsystems and produces summary information used in forming the trigger decision for each event. The system design is based on the use of state-of-the-art reconfigurable logic devices and fast data links. The basic structure, logic of operation and distinctive features of the system are presented.

A Topological Array Trigger for AGIS, the Advanced Gamma ray Imaging System

NASA Astrophysics Data System (ADS)

Krennrich, F.; Anderson, J.; Buckley, J.; Byrum, K.; Dawson, J.; Drake, G.; Haberichter, W.; Imran, A.; Krawczynski, H.; Kreps, A.; Schroedter, M.; Smith, A.

2008-12-01

Next generation ground based γ-ray observatories such as AGIS1 and CTA2 are expected to cover a 1 km2 area with 50-100 imaging atmospheric Cherenkov telescopes. The stereoscopic view ol air showers using multiple view points raises the possibility to use a topological array trigger that adds substantial flexibility, new background suppression capabilities and a reduced energy threshold. In this paper we report on the concept and technical implementation of a fast topological trigger system, that makes use of real time image processing of individual camera patterns and their combination in a stereoscopic array analysis. A prototype system is currently under construction and we discuss the design and hardware of this topological array trigger system.

Acquisition of gamma camera and physiological data by computer.

PubMed

Hack, S N; Chang, M; Line, B R; Cooper, J A; Robeson, G H

1986-11-01

We have designed, implemented, and tested a new Research Data Acquisition System (RDAS) that permits a general purpose digital computer to acquire signals from both gamma camera sources and physiological signal sources concurrently. This system overcomes the limited multi-source, high speed data acquisition capabilities found in most clinically oriented nuclear medicine computers. The RDAS can simultaneously input signals from up to four gamma camera sources with a throughput of 200 kHz per source and from up to eight physiological signal sources with an aggregate throughput of 50 kHz. Rigorous testing has found the RDAS to exhibit acceptable linearity and timing characteristics. In addition, flood images obtained by this system were compared with flood images acquired by a commercial nuclear medicine computer system. National Electrical Manufacturers Association performance standards of the flood images were found to be comparable.

Quality controls for gamma cameras and PET cameras: development of a free open-source ImageJ program

NASA Astrophysics Data System (ADS)

Carlier, Thomas; Ferrer, Ludovic; Berruchon, Jean B.; Cuissard, Regis; Martineau, Adeline; Loonis, Pierre; Couturier, Olivier

2005-04-01

Acquisition data and treatments for quality controls of gamma cameras and Positron Emission Tomography (PET) cameras are commonly performed with dedicated program packages, which are running only on manufactured computers and differ from each other, depending on camera company and program versions. The aim of this work was to develop a free open-source program (written in JAVA language) to analyze data for quality control of gamma cameras and PET cameras. The program is based on the free application software ImageJ and can be easily loaded on any computer operating system (OS) and thus on any type of computer in every nuclear medicine department. Based on standard parameters of quality control, this program includes 1) for gamma camera: a rotation center control (extracted from the American Association of Physics in Medicine, AAPM, norms) and two uniformity controls (extracted from the Institute of Physics and Engineering in Medicine, IPEM, and National Electronic Manufacturers Association, NEMA, norms). 2) For PET systems, three quality controls recently defined by the French Medical Physicist Society (SFPM), i.e. spatial resolution and uniformity in a reconstructed slice and scatter fraction, are included. The determination of spatial resolution (thanks to the Point Spread Function, PSF, acquisition) allows to compute the Modulation Transfer Function (MTF) in both modalities of cameras. All the control functions are included in a tool box which is a free ImageJ plugin and could be soon downloaded from Internet. Besides, this program offers the possibility to save on HTML format the uniformity quality control results and a warning can be set to automatically inform users in case of abnormal results. The architecture of the program allows users to easily add any other specific quality control program. Finally, this toolkit is an easy and robust tool to perform quality control on gamma cameras and PET cameras based on standard computation parameters, is free, run on

Dual-Particle Imaging System with Neutron Spectroscopy for Safeguard Applications

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hamel, Michael C.; Weber, Thomas M.

2017-11-01

A dual-particle imager (DPI) has been designed that is capable of detecting gamma-ray and neutron signatures from shielded SNM. The system combines liquid organic and NaI(Tl) scintillators to form a combined Compton and neutron scatter camera. Effective image reconstruction of detected particles is a crucial component for maximizing the performance of the system; however, a key deficiency exists in the widely used iterative list-mode maximum-likelihood estimation-maximization (MLEM) image reconstruction technique. For MLEM a stopping condition is required to achieve a good quality solution but these conditions fail to achieve maximum image quality. Stochastic origin ensembles (SOE) imaging is a goodmore » candidate to address this problem as it uses Markov chain Monte Carlo to reach a stochastic steady-state solution. The application of SOE to the DPI is presented in this work.« less

Cen A Optical Gamma Composite

NASA Image and Video Library

2017-12-08

NASA release April 1, 2010 The gamma-ray output from Cen A's lobes exceeds their radio output by more than ten times. High-energy gamma rays detected by Fermi's Large Area Telescope are depicted as purple in this gamma ray/optical composite of the galaxy. Credit: NASA/DOE/Fermi LAT Collaboration, Capella Observatory To learn more about these images go to: www.nasa.gov/mission_pages/GLAST/news/smokestack-plumes.html NASA Goddard Space Flight Center is home to the nation's largest organization of combined scientists, engineers and technologists that build spacecraft, instruments and new technology to study the Earth, the sun, our solar system, and the universe.

Description of a prototype emission-transmission computed tomography imaging system

NASA Technical Reports Server (NTRS)

Lang, T. F.; Hasegawa, B. H.; Liew, S. C.; Brown, J. K.; Blankespoor, S. C.; Reilly, S. M.; Gingold, E. L.; Cann, C. E.

1992-01-01

We have developed a prototype imaging system that can perform simultaneous x-ray transmission CT and SPECT phantom studies. This system employs a 23-element high-purity-germanium detector array. The detector array is coupled to a collimator with septa angled toward the focal spot of an x-ray tube. During image acquisition, the x-ray fan beam and the detector array move synchronously along an arc pivoted at the x-ray source. Multiple projections are obtained by rotating the object, which is mounted at the center of rotation of the system. The detector array and electronics can count up to 10(6) cps/element with sufficient energy-resolution to discriminate between x-rays at 100-120 kVp and gamma rays from 99mTc. We have used this device to acquire x-ray CT and SPECT images of a three-dimensional Hoffman brain phantom. The emission and transmission images may be superimposed in order to localize the emission image on the transmission map.

High-resolution continuum and Br (gamma) imaging observations of M82

NASA Technical Reports Server (NTRS)

Larkin, J. E.; Graham, J. R.; Matthews, K.; Soifer, B. T.; Beckwith, S.; Herbst, T. M.; Quillen, A. C.

1994-01-01

We report high angular resolution (about 0.6 sec), broad-band imaging at 1.2 microns (J band), 1.6 microns (H band), 2.2 microns (K band), and 3.7 microns (L' band) of the central 110 sec x 21 sec (1.65 kpc x 0.32 kpc) of the nearby starburst galaxy M82. We also present spectral imaging with 90 km/s resolution in the Br (gamma) (2.17 microns) hydrogen recombination line covering the central 16 sec x 16 sec (240 pc x 240 pc) of this edge-on, disk galaxy. The broad-band mosaics reveal two plateaus of emission indicative of an inner disk of stars and perhaps a larger bar structure. Color maps reveal an extinction ridge running along the central kiloparsec which is strongest at the nucleus and on the western side. The dust emission is more symmetric, suggesting that a dust lane is in front of the stellar population to the west of the nucleus, and behind the stars to the east; this is again suggestive of a stellar bar with leading dust lanes. Channel maps and a position-velocity image of the Br (gamma) reveal two lobes and are consistent with the interpretation that the ionized gas, and hence, the young massive stars are distributed in a toroid of H II regions surrounding the nucleus.

Terrestrial Gamma-Ray Flashes (TGFs)

NASA Technical Reports Server (NTRS)

Fishman, Gerald J.

2010-01-01

This slide presentation reviews the observation of Terrestrial Gamma Ray Flashes (TGFs) by Gamma-Ray Telescopes. These were: (1) BATSE /Compton Observatory, (2) Solar Spectroscopic Imager, (3) AGILE Gamma-ray Telescope, and (4) Gamma-ray Burst Monitor (GBM) on the Fermi Gamma-ray Space Telescope. It contains charts which display the counts over time, a map or the TGFs observed by the Reuven Ramaty High Energy Solar Spectroscopic Imager (RHESSI). and a map showing the latitude and longitude of 85 of the TGFs observed by the Fermi GBM.

3-dimensional imaging system using crystal diffraction lenses

DOEpatents

Smither, R.K.

1999-02-09

A device for imaging a plurality of sources of x-ray and gamma-ray radiation is provided. Diffracting crystals are used for focusing the radiation and directing the radiation to a detector which is used for analyzing their addition to collect data as to the location of the source of radiation. A computer is used for converting the data to an image. The invention also provides for a method for imaging x-ray and gamma radiation by supplying a plurality of sources of radiation; focusing the radiation onto a detector; analyzing the focused radiation to collect data as to the type and location of the radiation; and producing an image using the data. 18 figs.

Development of a multi-knife-edge slit collimator for prompt gamma ray imaging during proton beam cancer therapy

NASA Astrophysics Data System (ADS)

Ready, John Francis, III

Proton beam usage to treat cancer has recently experienced rapid growth, as it offers the ability to target dose delivery in a patient more precisely than traditional x-ray treatment methods. Protons stop within the patient, delivering the maximum dose at the end of their track--a phenomenon described as the Bragg peak. However, because a large dose is delivered to a small volume, proton therapy is very sensitive to errors in patient setup and treatment planning calculations. Additionally, because all primary beam particles stop in the patient, there is no direct information available to verify dose delivery. These factors contribute to the range uncertainty in proton therapy, which ultimately hinders its clinical usefulness. A reliable method of proton range verification would allow the clinician to fully utilize the precise dose delivery of the Bragg peak. Several methods to verify proton range detect secondary emissions, especially prompt gamma ray (PG) emissions. However, detection of PGs is challenging due to their high energy (2-10 MeV) and low attenuation coefficients, which limit PG interactions in materials. Therefore, detection and collimation methods must be specifically designed for prompt gamma ray imaging (PGI) applications. In addition, production of PGs relies on delivering a dose of radiation to the patient. Ideally, verification of the Bragg peak location exposes patients to a minimal dose, thus limiting the PG counts available to the imaging system. An additional challenge for PGI is the lack of accurate simulation models, which limit the study of PG production characteristics and the relationship between PG distribution and dose delivery. Specific limitations include incorrect modeling of the reaction cross sections, gamma emission yields, and angular distribution of emission for specific photon energies. While simulations can still be valuable assets in designing a system to detect and image PGs, until new models are developed and incorporated

Spectroscopic CZT detectors development for x- and gamma-ray imaging instruments

NASA Astrophysics Data System (ADS)

Quadrini, Egidio M.; Uslenghi, Michela; Alderighi, Monica; Casini, Fabio; D'Angelo, Sergio; Fiorini, Mauro; La Palombara, Nicola; Mancini, Marcello; Monti, Serena; Bazzano, Angela; Di Cosimo, Sergio; Frutti, Massimo; Natalucci, Lorenzo; Ubertini, Pietro; Guadalupi, Giuseppe M.; Sassi, Matteo; Negri, Barbara

2007-09-01

In the context of R&D studies financed by the Italian Space Agency (ASI), a feasibility study to evaluate the Italian Industry interest in medium-large scale production of enhanced CZT detectors has been performed by an Italian Consortium. The R&D investment aims at providing in-house source of high quality solid state spectrometers for Space Astrophysics applications. As a possible spin-off industrial applications to Gamma-ray devices for non-destructive inspections in medical, commercial and security fields have been considered by ASI. The short term programme mainly consists of developing proprietary procedures for 2-3" CZT crystals growth, including bonding and contact philosophy, and a newly designed low-power electronics readout chain. The prototype design and breadboarding is based on a fast signal AD conversion with the target in order to perform a new run for an already existing low-power (<0.7 mW/pixel) ASIC. The prototype also provides digital photon energy reconstruction with particular care for multiple events and polarimetry evaluations. Scientific requirement evaluations for Space Astrophysics Satellite applications have been carried out in parallel, targeted to contribute to the ESA Cosmic Vision 2015-2025 Announcement of Opportunity. Detailed accommodation studies are undergoing, as part of this programme, to size a "Large area arcsecond angular resolution Imager" for the Gamma Ray Imager satellite (Knödlseder et al., this conference).and a new Gamma-ray Wide Field Camera for the "EDGE" proposal (Piro et al., this conference). Finally, an extended market study for cost analysis evaluation in view of the foreseen massive detector production has been performed.

Z{gamma}{gamma}{gamma} {yields} 0 Processes in SANC

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bardin, D. Yu., E-mail: bardin@nu.jinr.ru; Kalinovskaya, L. V., E-mail: kalinov@nu.jinr.ru; Uglov, E. D., E-mail: corner@nu.jinr.ru

2013-11-15

We describe the analytic and numerical evaluation of the {gamma}{gamma} {yields} {gamma}Z process cross section and the Z {yields} {gamma}{gamma}{gamma} decay rate within the SANC system multi-channel approach at the one-loop accuracy level with all masses taken into account. The corresponding package for numeric calculations is presented. For checking of the results' correctness we make a comparison with the other independent calculations.

First On-Site True Gamma-Ray Imaging-Spectroscopy of Contamination near Fukushima Plant

PubMed Central

Tomono, Dai; Mizumoto, Tetsuya; Takada, Atsushi; Komura, Shotaro; Matsuoka, Yoshihiro; Mizumura, Yoshitaka; Oda, Makoto; Tanimori, Toru

2017-01-01

We have developed an Electron Tracking Compton Camera (ETCC), which provides a well-defined Point Spread Function (PSF) by reconstructing a direction of each gamma as a point and realizes simultaneous measurement of brightness and spectrum of MeV gamma-rays for the first time. Here, we present the results of our on-site pilot gamma-imaging-spectroscopy with ETCC at three contaminated locations in the vicinity of the Fukushima Daiichi Nuclear Power Plants in Japan in 2014. The obtained distribution of brightness (or emissivity) with remote-sensing observations is unambiguously converted into the dose distribution. We confirm that the dose distribution is consistent with the one taken by conventional mapping measurements with a dosimeter physically placed at each grid point. Furthermore, its imaging spectroscopy, boosted by Compton-edge-free spectra, reveals complex radioactive features in a quantitative manner around each individual target point in the background-dominated environment. Notably, we successfully identify a “micro hot spot” of residual caesium contamination even in an already decontaminated area. These results show that the ETCC performs exactly as the geometrical optics predicts, demonstrates its versatility in the field radiation measurement, and reveals potentials for application in many fields, including the nuclear industry, medical field, and astronomy. PMID:28155883

Telescope for x ray and gamma ray studies in astrophysics

NASA Technical Reports Server (NTRS)

Weaver, W. D.; Desai, Upendra D.

1993-01-01

Imaging of x-rays has been achieved by various methods in astrophysics, nuclear physics, medicine, and material science. A new method for imaging x-ray and gamma-ray sources avoids the limitations of previously used imaging devices. Images are formed in optical wavelengths by using mirrors or lenses to reflect and refract the incoming photons. High energy x-ray and gamma-ray photons cannot be reflected except at grazing angles and pass through lenses without being refracted. Therefore, different methods must be used to image x-ray and gamma-ray sources. Techniques using total absorption, or shadow casting, can provide images in x-rays and gamma-rays. This new method uses a coder made of a pair of Fresnel zone plates and a detector consisting of a matrix of CsI scintillators and photodiodes. The Fresnel zone plates produce Moire patterns when illuminated by an off-axis source. These Moire patterns are deconvolved using a stepped sine wave fitting or an inverse Fourier transform. This type of coder provides the capability of an instantaneous image with sub-arcminute resolution while using a detector with only a coarse position-sensitivity. A matrix of the CsI/photodiode detector elements provides the necessary coarse position-sensitivity. The CsI/photodiode detector also allows good energy resolution. This imaging system provides advantages over previously used imaging devices in both performance and efficiency.

Tycho's Star Shines in Gamma Rays

NASA Image and Video Library

2017-12-08

NASA image relase December 13, 2011 Gamma-rays detected by Fermi's LAT show that the remnant of Tycho's supernova shines in the highest-energy form of light. This portrait of the shattered star includes gamma rays (magenta), X-rays (yellow, green, and blue), infrared (red) and optical data. Credit: Gamma ray, NASA/DOE/Fermi LAT Collaboration; X-ray, NASA/CXC/SAO; Infrared, NASA/JPL-Caltech; Optical, MPIA, Calar Alto, O. Krause et al. and DSS To read more go to: www.nasa.gov/mission_pages/GLAST/news/tycho-star.html NASA image use policy. NASA Goddard Space Flight Center enables NASA’s mission through four scientific endeavors: Earth Science, Heliophysics, Solar System Exploration, and Astrophysics. Goddard plays a leading role in NASA’s accomplishments by contributing compelling scientific knowledge to advance the Agency’s mission. Follow us on Twitter Like us on Facebook Find us on Instagram

Comparison of myocardial perfusion imaging between the new high-speed gamma camera and the standard anger camera.

PubMed

Tanaka, Hirokazu; Chikamori, Taishiro; Hida, Satoshi; Uchida, Kenji; Igarashi, Yuko; Yokoyama, Tsuyoshi; Takahashi, Masaki; Shiba, Chie; Yoshimura, Mana; Tokuuye, Koichi; Yamashina, Akira

2013-01-01

Cadmium-zinc-telluride (CZT) solid-state detectors have been recently introduced into the field of myocardial perfusion imaging. The aim of this study was to prospectively compare the diagnostic performance of the CZT high-speed gamma camera (Discovery NM 530c) with that of the standard 3-head gamma camera in the same group of patients. The study group consisted of 150 consecutive patients who underwent a 1-day stress-rest (99m)Tc-sestamibi or tetrofosmin imaging protocol. Image acquisition was performed first on a standard gamma camera with a 15-min scan time each for stress and for rest. All scans were immediately repeated on a CZT camera with a 5-min scan time for stress and a 3-min scan time for rest, using list mode. The correlations between the CZT camera and the standard camera for perfusion and function analyses were strong within narrow Bland-Altman limits of agreement. Using list mode analysis, image quality for stress was rated as good or excellent in 97% of the 3-min scans, and in 100% of the ≥4-min scans. For CZT scans at rest, similarly, image quality was rated as good or excellent in 94% of the 1-min scans, and in 100% of the ≥2-min scans. The novel CZT camera provides excellent image quality, which is equivalent to standard myocardial single-photon emission computed tomography, despite a short scan time of less than half of the standard time.

Gamma-Ray Background Variability in Mobile Detectors

NASA Astrophysics Data System (ADS)

Aucott, Timothy John

Gamma-ray background radiation significantly reduces detection sensitivity when searching for radioactive sources in the field, such as in wide-area searches for homeland security applications. Mobile detector systems in particular must contend with a variable background that is not necessarily known or even measurable a priori. This work will present measurements of the spatial and temporal variability of the background, with the goal of merging gamma-ray detection, spectroscopy, and imaging with contextual information--a "nuclear street view" of the ubiquitous background radiation. The gamma-ray background originates from a variety of sources, both natural and anthropogenic. The dominant sources in the field are the primordial isotopes potassium-40, uranium-238, and thorium-232, as well as their decay daughters. In addition to the natural background, many artificially-created isotopes are used for industrial or medical purposes, and contamination from fission products can be found in many environments. Regardless of origin, these backgrounds will reduce detection sensitivity by adding both statistical as well as systematic uncertainty. In particular, large detector arrays will be limited by the systematic uncertainty in the background and will suffer from a high rate of false alarms. The goal of this work is to provide a comprehensive characterization of the gamma-ray background and its variability in order to improve detection sensitivity and evaluate the performance of mobile detectors in the field. Large quantities of data are measured in order to study their performance at very low false alarm rates. Two different approaches, spectroscopy and imaging, are compared in a controlled study in the presence of this measured background. Furthermore, there is additional information that can be gained by correlating the gamma-ray data with contextual data streams (such as cameras and global positioning systems) in order to reduce the variability in the background

High time resolved electron temperature measurements by using the multi-pass Thomson scattering system in GAMMA 10/PDX.

PubMed

Yoshikawa, Masayuki; Yasuhara, Ryo; Ohta, Koichi; Chikatsu, Masayuki; Shima, Yoriko; Kohagura, Junko; Sakamoto, Mizuki; Nakashima, Yousuke; Imai, Tsuyoshi; Ichimura, Makoto; Yamada, Ichihiro; Funaba, Hisamichi; Minami, Takashi

2016-11-01

High time resolved electron temperature measurements are useful for fluctuation study. A multi-pass Thomson scattering (MPTS) system is proposed for the improvement of both increasing the TS signal intensity and time resolution. The MPTS system in GAMMA 10/PDX has been constructed for enhancing the Thomson scattered signals for the improvement of measurement accuracy. The MPTS system has a polarization-based configuration with an image relaying system. We optimized the image relaying optics for improving the multi-pass laser confinement and obtaining the stable MPTS signals over ten passing TS signals. The integrated MPTS signals increased about five times larger than that in the single pass system. Finally, time dependent electron temperatures were obtained in MHz sampling.

AGIS: A Next-generation TeV Gamma-ray Observatory

NASA Astrophysics Data System (ADS)

Vandenbroucke, Justin

2010-05-01

The Advanced Gamma-ray Imaging System (AGIS) is a next-generation array of imaging atmospheric Cherenkov telescopes for gamma-ray astronomy in the 100 GeV to 100 TeV band. TeV astronomy has flourished in the last few years. Together with the extremely successful first year of the Fermi LAT telescope for GeV gamma-ray astronomy, we are now in a golden age of gamma-ray astronomy. AGIS seeks to continue the success of gamma-ray astronomy by discovering hundreds of new TeV sources and improving our understanding of known sources, as well as searching for signals from dark matter annihilation. AGIS will feature 36 Schwarzschild-Couder (SC) telescopes spanning 1 km2. The two-mirror SC design allows a wide field of view (8 deg diameter) and high-resolution (0.05 deg diameter) pixellation. I will present the science capabilities of the AGIS observatory as well as the technical design and current status of the project.

Fast-neutron and gamma-ray imaging with a capillary liquid xenon converter coupled to a gaseous photomultiplier

NASA Astrophysics Data System (ADS)

Israelashvili, I.; Coimbra, A. E. C.; Vartsky, D.; Arazi, L.; Shchemelinin, S.; Caspi, E. N.; Breskin, A.

2017-09-01

Gamma-ray and fast-neutron imaging was performed with a novel liquid xenon (LXe) scintillation detector read out by a Gaseous Photomultiplier (GPM). The 100 mm diameter detector prototype comprised a capillary-filled LXe converter/scintillator, coupled to a triple-THGEM imaging-GPM, with its first electrode coated by a CsI UV-photocathode, operated in Ne/5%CH4 at cryogenic temperatures. Radiation localization in 2D was derived from scintillation-induced photoelectron avalanches, measured on the GPM's segmented anode. The localization properties of 60Co gamma-rays and a mixed fast-neutron/gamma-ray field from an AmBe neutron source were derived from irradiation of a Pb edge absorber. Spatial resolutions of 12± 2 mm and 10± 2 mm (FWHM) were reached with 60Co and AmBe sources, respectively. The experimental results are in good agreement with GEANT4 simulations. The calculated ultimate expected resolutions for our application-relevant 4.4 and 15.1 MeV gamma-rays and 1-15 MeV neutrons are 2-4 mm and ~ 2 mm (FWHM), respectively. These results indicate the potential applicability of the new detector concept to Fast-Neutron Resonance Radiography (FNRR) and Dual-Discrete-Energy Gamma Radiography (DDEGR) of large objects.

Prospects for Dark Matter Measurements with the Advanced Gamma Ray Imaging System (AGIS)

NASA Astrophysics Data System (ADS)

Buckley, James

2009-05-01

AGIS, a concept for a future gamma-ray observatory consisting of an array of 50 atmospheric Cherenkov telescopes, would provide a powerful new tool for determining the nature of dark matter and its role in structure formation in the universe. The advent of more sensitive direct detection experiments, the launch of Fermi and the startup of the LHC make the near future an exciting time for dark matter searches. Indirect measurements of cosmic-ray electrons may already provide a hint of dark matter in our local halo. However, gamma-ray measurements will provide the only means for mapping the dark matter in the halo of our galaxy and other galaxies. In addition, the spectrum of gamma-rays (either direct annihilation to lines or continuum emission from other annihilation channels) will be imprinted with the mass of the dark matter particle, and the particular annihilation channels providing key measurements needed to identify the dark matter particle. While current gamma-ray instruments fall short of the generic sensitivity required to measure the dark matter signal from any sources other than the (confused) region around the Galactic center, we show that the planned AGIS array will have the angular resolution, energy resolution, low threshold energy and large effective area required to detect emission from dark matter annihilation in Galactic substructure or nearby Dwarf spheroidal galaxies.

Estimation and correction of produced light from prompt gamma photons on luminescence imaging of water for proton therapy dosimetry

NASA Astrophysics Data System (ADS)

Yabe, Takuya; Komori, Masataka; Toshito, Toshiyuki; Yamaguchi, Mitsutaka; Kawachi, Naoki; Yamamoto, Seiichi

2018-02-01

Although the luminescence images of water during proton-beam irradiation using a cooled charge-coupled device camera showed almost the same ranges of proton beams as those measured by an ionization chamber, the depth profiles showed lower Bragg peak intensities than those measured by an ionization chamber. In addition, a broad optical baseline signal was observed in depths that exceed the depth of the Bragg peak. We hypothesize that this broad baseline signal originates from the interaction of proton-induced prompt gamma photons with water. These prompt gamma photons interact with water to form high-energy Compton electrons, which may cause luminescence or Cherenkov emission from depths exceeding the location of the Bragg peak. To clarify this idea, we measured the luminescence images of water during the irradiations of protons in water with minimized parallax errors, and also simulated the produced light by the interactions of prompt gamma photons with water. We corrected the measured depth profiles of the luminescence images by subtracting the simulated distributions of the produced light by the interactions of prompt gamma photons in water. Corrections were also conducted using the estimated depth profiles of the light of the prompt gamma photons, as obtained from the off-beam areas of the luminescence images of water. With these corrections, we successfully obtained depth profiles that have almost identical distributions as the simulated dose distributions for protons. The percentage relative height of the Bragg peak with corrections to that of the simulation data increased to 94% from 80% without correction. Also, the percentage relative offset heights of the deeper part of the Bragg peak with corrections decreased to 0.2%-0.4% from 4% without correction. These results indicate that the luminescence imaging of water has potential for the dose distribution measurements for proton therapy dosimetry.

Large-area PSPMT based gamma-ray imager with edge reclamation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ziock, K-P; Nakae, L

2000-09-21

We describe a coded aperture, gamma-ray imager which uses a CsI(Na) scintillator coupled to an Hamamatsu R3292 position-sensitive photomultiplier tube (PSPMT) as the position-sensitive detector. We have modified the normal resistor divider readout of the PSPMT to allow use of nearly the full 10 cm diameter active area of the PSPMT with a single scintillator crystal one centimeter thick. This is a significant performance improvement over that obtained with the standard readout technique where the linearity and position resolution start to degrade at radii as small as 3.5 cm with a crystal 0.75 crn thick. This represents a recovery ofmore » over 60% of the PSPMT active area. The performance increase allows the construction of an imager with a field of view 20 resolution elements in diameter with useful quantum efficiency from 60-700 keV. In this paper we describe the readout technique, its implementation in a coded aperture imager and the performance of that imager.« less

MO-F-CAMPUS-J-05: Using 2D Relative Gamma Analysis From EPID Image as a Predictor of Plan Deterioration Due to Anatomical Changes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Piron, O; Varfalvy, N; Archambault, L

2015-06-15

Purpose: One of the side effects of radiotherapy for head and neck (H&N) cancer is the patient’s anatomical changes. The changes can strongly affect the planned dose distribution. In this work, our goal is to demonstrate that relative analysis of EPID images is a fast and simple method to detect anatomical changes that can have a strong dosimetric impact on the treatment plan for H&N patients. Methods: EPID images were recorded at every beam and all fractions for 50 H&N patients. Of these, five patients that showed important anatomical changes were selected to evaluate dosimetric impacts of these changes andmore » to correlate them with a 2D relative gamma analysis of EPID images. The planning CT and original contours were deformed onto CBCTs (one mid treatment and one at the end of treatment). By using deformable image registration, it was possible to map accurate CT numbers from the planning CT to the anatomy of the day obtained with CBCTs. Clinical treatment plan were then copied on the deformed dataset and dose was re-computed. In parallel, EPID images were analysed using the gamma index (3%3mm) relative to the first image. Results: It was possible to divide patients in two distinct, statistically different (p<0.001) categories using an average gamma index of 0.5 as a threshold. Below this threshold no significant dosimetric degradation of the plan are observed. Above this threshold two types of plan deterioration were seen: (1) target dose increases, but coverage remains adequate while dose to at least one OAR increases beyond tolerances; (2) the OAR doses remain low, but the target dose is reduced and coverage becomes inadequate. Conclusion: Relative analysis gamma of EPID images could indeed be a fast and simple method to detect anatomical changes that can potentially deteriorates treatment plan for H&N patients. This work was supported in part by Varian Medical System.« less

SU-F-J-189: A Method to Improve the Spatial Resolution of Prompt Gamma Based Compton Imaging for Proton Range Verification

DOE Office of Scientific and Technical Information (OSTI.GOV)

Draeger, E; Chen, H; Polf, J

Purpose: To test two new techniques, the distance-of-closest approach (DCA) and Compton line (CL) filters, developed as a means of improving the spatial resolution of Compton camera (CC) imaging. Methods: Gammas emitted from {sup 22}Na, {sup 137}Cs, and {sup 60}Co point sources were measured with a prototype 3-stage CC. The energy deposited and position of each interaction in each stage were recorded and used to calculate a “cone-of-origin” for each gamma that scattered twice in the CC. A DCA filter was developed which finds the shortest distance from the gamma’s cone-of-origin surface to the location of the gamma source. Themore » DCA filter was applied to the data to determine the initial energy of the gamma and to remove “bad” interactions that only contribute noise to the image. Additionally, a CL filter, which removes gamma events that do not follow the theoretical predictions of the Compton scatter equation, was used to further remove “bad” interactions from the measured data. Then images were reconstructed with raw, unfiltered data, DCA filtered data, and DCA+CL filtered data and the achievable image resolution of each dataset was compared. Results: Spatial resolutions of ∼2 mm, and better than 2 mm, were achievable with the DCA and DCA+CL filtered data, respectively, compared to > 5 mm for the raw, unfiltered data. Conclusion: In many special cases in medical imaging where information about the source position may be known, such as proton radiotherapy range verification, the application of the DCA and CL filters can result in considerable improvements in the achievable spatial resolutions of Compton imaging.« less

Development of a high resolution liquid xenon imaging chamber for gamma-ray astronomy

NASA Technical Reports Server (NTRS)

Aprile, Elena

1991-01-01

The objective was to develop the technology of liquid xenon (LXe) detectors for spectroscopy and imaging of gamma rays from astrophysical sources emitting in the low to medium energy regime. In particular, the technical challenges and the physical processes relevant to the realization of the LXe detector operated as a Time Projection Chamber (TPC) were addressed and studied. Experimental results were obtained on the following topics: (1) long distance drift of free electrons in LXe (purity); (2) scintillation light yield for electrons and alphas in LXe (triggering); and (3) ionization yield for electrons and gamma rays in LXe (energy resolution). The major results from the investigations are summarized.

System Integration of FastSPECT III, a Dedicated SPECT Rodent-Brain Imager Based on BazookaSPECT Detector Technology

PubMed Central

Miller, Brian W.; Furenlid, Lars R.; Moore, Stephen K.; Barber, H. Bradford; Nagarkar, Vivek V.; Barrett, Harrison H.

2010-01-01

FastSPECT III is a stationary, single-photon emission computed tomography (SPECT) imager designed specifically for imaging and studying neurological pathologies in rodent brain, including Alzheimer’s and Parkinsons’s disease. Twenty independent BazookaSPECT [1] gamma-ray detectors acquire projections of a spherical field of view with pinholes selected for desired resolution and sensitivity. Each BazookaSPECT detector comprises a columnar CsI(Tl) scintillator, image-intensifier, optical lens, and fast-frame-rate CCD camera. Data stream back to processing computers via firewire interfaces, and heavy use of graphics processing units (GPUs) ensures that each frame of data is processed in real time to extract the images of individual gamma-ray events. Details of the system design, imaging aperture fabrication methods, and preliminary projection images are presented. PMID:21218137

The gamma-ray observatory

NASA Technical Reports Server (NTRS)

1991-01-01

An overview is given of the Gamma Ray Observatory (GRO) mission. Detection of gamma rays and gamma ray sources, operations using the Space Shuttle, and instruments aboard the GRO, including the Burst and Transient Source Experiment (BATSE), the Oriented Scintillation Spectrometer Experiment (OSSE), the Imaging Compton Telescope (COMPTEL), and the Energetic Gamma Ray Experiment Telescope (EGRET) are among the topics surveyed.

Image processing techniques revealing the relationship between the field-measured ambient gamma dose equivalent rate and geological conditions at a granitic area, Velence Mountains, Hungary

NASA Astrophysics Data System (ADS)

Beltran Torres, Silvana; Petrik, Attila; Zsuzsanna Szabó, Katalin; Jordan, Gyozo; Szabó, Csaba

2017-04-01

In order to estimate the annual dose that the public receive from natural radioactivity, the identification of the potential risk areas is required which, in turn, necessitates understanding the relationship between the spatial distribution of natural radioactivity and the geogenic risk factors (e.g., rock types, dykes, faults, soil conditions, etc.). A detailed spatial analysis of ambient gamma dose equivalent rate was performed in the western side of Velence Mountains, the largest outcropped granitic area in Hungary. In order to assess the role of local geology in the spatial distribution of ambient gamma dose rates, field measurements were carried out at ground level at 300 sites along a 250 m x 250 m regular grid in a total surface of 14.7 km2. Digital image processing methods were applied to identify anomalies, heterogeneities and spatial patterns in the measured gamma dose rates, including local maxima and minima determination, digital cross sections, gradient magnitude and gradient direction, second derivative profile curvature, local variability, lineament density, 2D autocorrelation and directional variogram analyses. Statistical inference showed that different gamma dose rate levels are associated with the rock types (i.e., Carboniferous granite, Pleistocene colluvial, proluvial, deluvial sediments and talus, and Pannonian sand and pebble), with the highest level on the Carboniferous granite including outlying values. Moreover, digital image processing revealed that linear gamma dose rate spatial features are parallel to the SW-NE dyke system and possibly to the NW-SE main fractures. The results of this study underline the importance of understanding the role of geogenic risk factors influencing the ambient gamma dose rate received by public. The study also demonstrates the power of the image processing techniques for the identification of spatial pattern in field-measured geogenic radiation.

A novel Compton camera design featuring a rear-panel shield for substantial noise reduction in gamma-ray images

NASA Astrophysics Data System (ADS)

Nishiyama, T.; Kataoka, J.; Kishimoto, A.; Fujita, T.; Iwamoto, Y.; Taya, T.; Ohsuka, S.; Nakamura, S.; Hirayanagi, M.; Sakurai, N.; Adachi, S.; Uchiyama, T.

2014-12-01

After the Japanese nuclear disaster in 2011, large amounts of radioactive isotopes were released and still remain a serious problem in Japan. Consequently, various gamma cameras are being developed to help identify radiation hotspots and ensure effective decontamination operation. The Compton camera utilizes the kinematics of Compton scattering to contract images without using a mechanical collimator, and features a wide field of view. For instance, we have developed a novel Compton camera that features a small size (13 × 14 × 15 cm3) and light weight (1.9 kg), but which also achieves high sensitivity thanks to Ce:GAGG scintillators optically coupled wiith MPPC arrays. By definition, in such a Compton camera, gamma rays are expected to scatter in the ``scatterer'' and then be fully absorbed in the ``absorber'' (in what is called a forward-scattered event). However, high energy gamma rays often interact with the detector in the opposite direction - initially scattered in the absorber and then absorbed in the scatterer - in what is called a ``back-scattered'' event. Any contamination of such back-scattered events is known to substantially degrade the quality of gamma-ray images, but determining the order of gamma-ray interaction based solely on energy deposits in the scatterer and absorber is quite difficult. For this reason, we propose a novel yet simple Compton camera design that includes a rear-panel shield (a few mm thick) consisting of W or Pb located just behind the scatterer. Since the energy of scattered gamma rays in back-scattered events is much lower than that in forward-scattered events, we can effectively discriminate and reduce back-scattered events to improve the signal-to-noise ratio in the images. This paper presents our detailed optimization of the rear-panel shield using Geant4 simulation, and describes a demonstration test using our Compton camera.

The agile alert system for gamma-ray transients

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bulgarelli, A.; Trifoglio, M.; Gianotti, F.

2014-01-20

In recent years, a new generation of space missions has offered great opportunities for discovery in high-energy astrophysics. In this article we focus on the scientific operations of the Gamma-Ray Imaging Detector (GRID) on board the AGILE space mission. AGILE-GRID, sensitive in the energy range of 30 MeV-30 GeV, has detected many γ-ray transients of both galactic and extragalactic origin. This work presents the AGILE innovative approach to fast γ-ray transient detection, which is a challenging task and a crucial part of the AGILE scientific program. The goals are to describe (1) the AGILE Gamma-Ray Alert System, (2) a newmore » algorithm for blind search identification of transients within a short processing time, (3) the AGILE procedure for γ-ray transient alert management, and (4) the likelihood of ratio tests that are necessary to evaluate the post-trial statistical significance of the results. Special algorithms and an optimized sequence of tasks are necessary to reach our goal. Data are automatically analyzed at every orbital downlink by an alert pipeline operating on different timescales. As proper flux thresholds are exceeded, alerts are automatically generated and sent as SMS messages to cellular telephones, via e-mail, and via push notifications from an application for smartphones and tablets. These alerts are crosschecked with the results of two pipelines, and a manual analysis is performed. Being a small scientific-class mission, AGILE is characterized by optimization of both scientific analysis and ground-segment resources. The system is capable of generating alerts within two to three hours of a data downlink, an unprecedented reaction time in γ-ray astrophysics.« less

The AGILE Alert System for Gamma-Ray Transients

NASA Astrophysics Data System (ADS)

Bulgarelli, A.; Trifoglio, M.; Gianotti, F.; Tavani, M.; Parmiggiani, N.; Fioretti, V.; Chen, A. W.; Vercellone, S.; Pittori, C.; Verrecchia, F.; Lucarelli, F.; Santolamazza, P.; Fanari, G.; Giommi, P.; Beneventano, D.; Argan, A.; Trois, A.; Scalise, E.; Longo, F.; Pellizzoni, A.; Pucella, G.; Colafrancesco, S.; Conforti, V.; Tempesta, P.; Cerone, M.; Sabatini, P.; Annoni, G.; Valentini, G.; Salotti, L.

2014-01-01

In recent years, a new generation of space missions has offered great opportunities for discovery in high-energy astrophysics. In this article we focus on the scientific operations of the Gamma-Ray Imaging Detector (GRID) on board the AGILE space mission. AGILE-GRID, sensitive in the energy range of 30 MeV-30 GeV, has detected many γ-ray transients of both galactic and extragalactic origin. This work presents the AGILE innovative approach to fast γ-ray transient detection, which is a challenging task and a crucial part of the AGILE scientific program. The goals are to describe (1) the AGILE Gamma-Ray Alert System, (2) a new algorithm for blind search identification of transients within a short processing time, (3) the AGILE procedure for γ-ray transient alert management, and (4) the likelihood of ratio tests that are necessary to evaluate the post-trial statistical significance of the results. Special algorithms and an optimized sequence of tasks are necessary to reach our goal. Data are automatically analyzed at every orbital downlink by an alert pipeline operating on different timescales. As proper flux thresholds are exceeded, alerts are automatically generated and sent as SMS messages to cellular telephones, via e-mail, and via push notifications from an application for smartphones and tablets. These alerts are crosschecked with the results of two pipelines, and a manual analysis is performed. Being a small scientific-class mission, AGILE is characterized by optimization of both scientific analysis and ground-segment resources. The system is capable of generating alerts within two to three hours of a data downlink, an unprecedented reaction time in γ-ray astrophysics.

A prototype small CdTe gamma camera for radioguided surgery and other imaging applications.

PubMed

Tsuchimochi, Makoto; Sakahara, Harumi; Hayama, Kazuhide; Funaki, Minoru; Ohno, Ryoichi; Shirahata, Takashi; Orskaug, Terje; Maehlum, Gunnar; Yoshioka, Koki; Nygard, Einar

2003-12-01

Gamma probes have been used for sentinel lymph node biopsy in melanoma and breast cancer. However, these probes can provide only radioactivity counts and variable pitch audio output based on the intensity of the detected radioactivity. We have developed a small semiconductor gamma camera (SSGC) that allows visualisation of the size, shape and location of the target tissues. This study is designed to characterise the performance of the SSGC for radioguided surgery of metastatic lesions and for other imaging applications amenable to the smaller format of this prototype imaging system. The detector head had 32 cadmium telluride semiconductor arrays with a total of 1,024 pixels, and with application-specific integrated circuits (ASICs) and a tungsten collimator. The entire assembly was encased in a lead housing measuring 152 mmx166 mmx65 mm. The effective visual field was 44.8 mmx44.8 mm. The energy resolution and imaging aspects were tested. Two spherical 5-mm- and 15-mm-diameter technetium-99m radioactive sources that had activities of 0.15 MBq and 100 MBq, respectively, were used to simulate a sentinel lymph node and an injection site. The relative detectability of these foci by the new detector and a conventional scintillation camera was studied. The prototype was also examined in a variety of clinical applications. Energy resolution [full-width at half-maximum (FWHM)] for a single element at the centre of the field of view was 4.2% at 140 keV (99mTc), and the mean energy resolution of the CdTe detector arrays was approximately 7.8%. The spatial resolution, represented by FWHM, had a mean value of 1.56 +/- 0.05 mm. Simulated node foci could be visualised clearly by the SSGC using a 15-s acquisition time. In preliminary clinical tests, the SSGC successfully imaged diseases in a variety of tissues, including salivary and thyroid glands, temporomandibular joints and sentinel lymph nodes. The SSGC has significant potential for diagnosing diseases and facilitating

131I activity quantification of gamma camera planar images

NASA Astrophysics Data System (ADS)

Barquero, Raquel; Garcia, Hugo P.; Incio, Monica G.; Minguez, Pablo; Cardenas, Alexander; Martínez, Daniel; Lassmann, Michael

2017-02-01

A procedure to estimate the activity in target tissues in patients during the therapeutic administration of 131I radiopharmaceutical treatment for thyroid conditions (hyperthyroidism and differentiated thyroid cancer) using a gamma camera (GC) with a high energy (HE) collimator, is proposed. Planar images are acquired for lesions of different sizes r, and at different distances d, in two HE GC systems. Defining a region of interest (ROI) on the image of size r, total counts n g are measured. Sensitivity S (cps MBq-1) in each acquisition is estimated as the product of the geometric G and the intrinsic efficiency η 0. The mean fluence of 364 keV photons arriving at the ROI per disintegration G, is calculated with the MCNPX code, simulating the entire GC and the HE collimator. Intrinsic efficiency η 0 is estimated from a calibration measurement of a plane reference source of 131I in air. Values of G and S for two GC systems—Philips Skylight and Siemens e-cam—are calculated. The total range of possible sensitivity values in thyroidal imaging in the e-cam and skylight GC measure from 7 cps MBq-1 to 35 cps MBq-1, and from 6 cps MBq-1 to 29 cps MBq-1, respectively. These sensitivity values have been verified with the SIMIND code, with good agreement between them. The results have been validated with experimental measurements in air, and in a medium with scatter and attenuation. The counts in the ROI can be produced by direct, scatter and penetration photons. The fluence value for direct photons is constant for any r and d values, but scatter and penetration photons show different values related to specific r and d values, resulting in the large sensitivity differences found. The sensitivity in thyroidal GC planar imaging is strongly dependent on uptake size, and distance from the GC. An individual value for the acquisition sensitivity of each lesion can significantly alleviate the level of uncertainty in the measurement of thyroid uptake activity for each patient.

Design upgrades to the DIII-D gamma ray imager

NASA Astrophysics Data System (ADS)

Lvovskiy, A.; Cooper, C. M.; Eidietis, N. W.; Pace, D.; Paz-Soldan, C.

2016-10-01

Generation of runaway electrons (RE) in tokamak disruptions can cause damage of plasma facing components. RE studies are necessary in order to provide a reliable mechanism of RE mitigation. For that task a gamma ray imager (GRI) has been developed for DIII-D. It measures the bremsstrahlung emission by RE providing information on RE energy spectrum and RE distribution across a poloidal cross-section. The GRI consists of a lead pinhole camera illuminating a 2D array of 30 BGO detectors placed in the DIII-D mid-plane. First results showed the successful measurements of RE energy spectra in the range 1 - 60 MeV with time resolution 100 μs. They have been obtained in the low-flux quiescent RE regime via pulse-high analysis. The measurements in the high gamma flux post-disruption RE regime showed strong signal saturation. Here we present GRI design upgrades towards signal attenuation and better detector shielding including Monte-Carlo Neutral Particle modeling of GRI irradiation, as well as improved calibration techniques and options to improve electronic noise rejection. Work supported by US DOE under DE-AC05-06OR23100 and DE-FC02-04ER54698.

Evaluation of 3D Gamma index calculation implemented in two commercial dosimetry systems

NASA Astrophysics Data System (ADS)

Xing, Aitang; Arumugam, Sankar; Deshpande, Shrikant; George, Armia; Vial, Philip; Holloway, Lois; Goozee, Gary

2015-01-01

3D Gamma index is one of the metrics which have been widely used for clinical routine patient specific quality assurance for IMRT, Tomotherapy and VMAT. The algorithms for calculating the 3D Gamma index using global and local methods implemented in two software tools: PTW- VeriSoft® as a part of OCTIVIUS 4D dosimeter systems and 3DVHTM from Sun Nuclear were assessed. The Gamma index calculated by the two systems was compared with manual calculated for one data set. The Gamma pass rate calculated by the two systems was compared using 3%/3mm, 2%/2mm, 3%/2mm and 2%/3mm for two additional data sets. The Gamma indexes calculated by the two systems were accurate, but Gamma pass rates calculated by the two software tools for same data set with the same dose threshold were different due to the different interpolation of raw dose data by the two systems and different implementation of Gamma index calculation and other modules in the two software tools. The mean difference was -1.3%±3.38 (1SD) with a maximum difference of 11.7%.

GammaScorpion: mobile gamma-ray tomography system for early detection of basal stem rot in oil palm plantations

NASA Astrophysics Data System (ADS)

Abdullah, Jaafar; Hassan, Hearie; Shari, Mohamad Rabaie; Mohd, Salzali; Mustapha, Mahadi; Mahmood, Airwan Affendi; Jamaludin, Shahrizan; Ngah, Mohd Rosdi; Hamid, Noor Hisham

2013-03-01

Detection of the oil palm stem rot disease Ganoderma is a major issue in estate management and production in Malaysia. Conventional diagnostic techniques are difficult and time consuming when using visual inspection, and destructive and expensive when based on the chemical analysis of root or stem tissue. As an alternative, a transportable gamma-ray computed tomography system for the early detection of basal stem rot (BSR) of oil palms due to Ganoderma was developed locally at the Malaysian Nuclear Agency, Kajang, Malaysia. This system produces high quality tomographic images that clearly differentiate between healthy and Ganoderma infected oil palm stems. It has been successfully tested and used to detect the extent of BSR damage in oil palm plantations in Malaysia without the need to cut down the trees. This method offers promise for in situ inspection of oil palm stem diseases compared to the more conventional methods.

Ultralow-dose, feedback imaging with laser-Compton X-ray and laser-Compton gamma ray sources

DOE Office of Scientific and Technical Information (OSTI.GOV)

Barty, Christopher P. J.

Ultralow-dose, x-ray or gamma-ray imaging is based on fast, electronic control of the output of a laser-Compton x-ray or gamma-ray source (LCXS or LCGS). X-ray or gamma-ray shadowgraphs are constructed one (or a few) pixel(s) at a time by monitoring the LCXS or LCGS beam energy required at each pixel of the object to achieve a threshold level of detectability at the detector. An example provides that once the threshold for detection is reached, an electronic or optical signal is sent to the LCXS/LCGS that enables a fast optical switch that diverts, either in space or time the laser pulsesmore » used to create Compton photons. In this way, one prevents the object from being exposed to any further Compton x-rays or gamma-rays until either the laser-Compton beam or the object are moved so that a new pixel location may be illumination.« less

Experimental study of the vidicon system for information recording using the wide-gap spark chamber of gamma - telescope gamma-I

NASA Technical Reports Server (NTRS)

Akimov, V. V.; Bazer-Bashv, R.; Voronov, S. A.; Galper, A. M.; Gro, M.; Kalinkin, L. F.; Kerl, P.; Kozlov, V. D.; Koten, F.; Kretol, D.

1979-01-01

The development of the gamma ray telescope is investigated. The wide gap spark chambers, used to identify the gamma quanta and to determine the directions of their arrival, are examined. Two systems of information recording with the spark chambers photographic and vidicon system are compared.

Olfactory system gamma oscillations: the physiological dissection of a cognitive neural system

PubMed Central

Rojas-Líbano, Daniel

2008-01-01

Oscillatory phenomena have been a focus of dynamical systems research since the time of the classical studies on the pendulum by Galileo. Fast cortical oscillations also have a long and storied history in neurophysiology, and olfactory oscillations have led the way with a depth of explanation not present in the literature of most other cortical systems. From the earliest studies of odor-evoked oscillations by Adrian, many reports have focused on mechanisms and functional associations of these oscillations, in particular for the so-called gamma oscillations. As a result, much information is now available regarding the biophysical mechanisms that underlie the oscillations in the mammalian olfactory system. Recent studies have expanded on these and addressed functionality directly in mammals and in the analogous insect system. Sub-bands within the rodent gamma oscillatory band associated with specific behavioral and cognitive states have also been identified. All this makes oscillatory neuronal networks a unique interdisciplinary platform from which to study neurocognitive and dynamical phenomena in intact, freely behaving animals. We present here a summary of what has been learned about the functional role and mechanisms of gamma oscillations in the olfactory system as a guide for similar studies in other cortical systems. PMID:19003484

Vaginal distribution and retention of a multiparticulate drug delivery system, assessed by gamma scintigraphy and magnetic resonance imaging.

PubMed

Mehta, Samata; Verstraelen, Hans; Peremans, Kathelijne; Villeirs, Geert; Vermeire, Simon; De Vos, Filip; Mehuys, Els; Remon, Jean Paul; Vervaet, Chris

2012-04-15

For any new vaginal dosage form, the distribution and retention in the vagina has to be assessed by in vivo evaluation. We evaluated the vaginal distribution and retention of starch-based pellets in sheep as live animal model by gamma scintigraphy (using Indium-111 DTPA as radiolabel) and in women via magnetic resonance imaging (MRI, using a gadolinium chelate as contrast agent). A conventional cream formulation was used as reference in both studies. Cream and pellets were administered to sheep (n=6) in a two period-two treatment study and to healthy female volunteers (n=6) via a randomized crossover trial. Pellets (filled into hard gelatin capsule) and cetomacrogol cream, both labeled with Indium-111 DTPA (for gamma scintigraphy) or with gadolinium chelate (for MRI) were evaluated for their intravaginal distribution and retention over a 24h period. Spreading in the vagina was assessed based on the part of the vagina covered with formulation (expressed in relation to the total vaginal length). Vaginal retention of the formulation was quantified based on the radioactivity remaining in the vaginal area (sheep study), or qualitatively evaluated (women study). Both trials indicated a rapid distribution of the cream within the vagina as complete coverage of the vaginal mucosa was seen 1h after dose administration. Clearance of the cream was rapid: about 10% activity remained in the vaginal area of the sheep 12h post-administration, while after 8h only a thin layer of cream was detected on the vaginal mucosa of women. After disintegration of the hard gelatin capsule, the pellet formulation gradually distributed over the entire vaginal mucosa. Residence time of the pellets in the vagina was longer compared to the semi-solid formulation: after 24h 23 ± 7% radioactivity was detected in the vaginal area of the sheep, while in women the pellet formulation was still detected throughout the vagina. A multi-particulate system containing starch-based pellets was identified as a

Development of an omnidirectional gamma-ray imaging Compton camera for low-radiation-level environmental monitoring

NASA Astrophysics Data System (ADS)

Watanabe, Takara; Enomoto, Ryoji; Muraishi, Hiroshi; Katagiri, Hideaki; Kagaya, Mika; Fukushi, Masahiro; Kano, Daisuke; Satoh, Wataru; Takeda, Tohoru; Tanaka, Manobu M.; Tanaka, Souichi; Uchida, Tomohisa; Wada, Kiyoto; Wakamatsu, Ryo

2018-02-01

We have developed an omnidirectional gamma-ray imaging Compton camera for environmental monitoring at low levels of radiation. The camera consisted of only six CsI(Tl) scintillator cubes of 3.5 cm, each of which was readout by super-bialkali photo-multiplier tubes (PMTs). Our camera enables the visualization of the position of gamma-ray sources in all directions (∼4π sr) over a wide energy range between 300 and 1400 keV. The angular resolution (σ) was found to be ∼11°, which was realized using an image-sharpening technique. A high detection efficiency of 18 cps/(µSv/h) for 511 keV (1.6 cps/MBq at 1 m) was achieved, indicating the capability of this camera to visualize hotspots in areas with low-radiation-level contamination from the order of µSv/h to natural background levels. Our proposed technique can be easily used as a low-radiation-level imaging monitor in radiation control areas, such as medical and accelerator facilities.

Application of CdZnTe Gamma-Ray Detector for Imaging Corrosion under Insulation

NASA Astrophysics Data System (ADS)

Abdullah, J.; Yahya, R.

2007-05-01

Corrosion under insulation (CUI) on the external wall of steel pipes is a common problem in many types of industrial plants. This is mainly due to the presence of moisture or water in the insulation materials. This type of corrosion can cause failures in areas that are not normally of a primary concern to an inspection program. The failures are often the result of localised corrosion and not general wasting over a large area. These failures can tee catastrophic in nature or at least have an adverse economic effect in terms of downtime and repairs. There are a number of techniques used today for CUI investigations. The main ones are profile radiography, pulse eddy current, ultrasonic spot readings and insulation removal. A new system now available is portable Pipe-CUI-Profiler. The nucleonic system is based on dual-beam gamma-ray absorption technique using Cadmium Zinc Telluride (CdZnTe) semiconductor detectors. The Pipe-CUI-Profiler is designed to inspect pipes of internal diameter 50, 65, 80, 90, 100, 125 and 150 mm. Pipeline of these sizes with aluminium or thin steel sheathing, containing fibreglass or calcium silicate insulation to thickness of 25, 40 and 50 mm can be inspected. The system has proven to be a safe, fast and effective method of inspecting pipe in industrial plant operations. This paper describes the application of gamma-ray techniques and CdZnTe semiconductor detectors in the development of Pipe-CUI-Profiler for non-destructive imaging of corrosion under insulation of steel pipes. Some results of actual pipe testing in large-scale industrial plant will be presented.

The Advanced Gamma-ray Imaging System (AGIS): A Nanosecond Time Scale Stereoscopic Array Trigger System.

NASA Astrophysics Data System (ADS)

Krennrich, Frank; Buckley, J.; Byrum, K.; Dawson, J.; Drake, G.; Horan, D.; Krawzcynski, H.; Schroedter, M.

2008-04-01

Imaging atmospheric Cherenkov telescope arrays (VERITAS, HESS) have shown unprecedented background suppression capabilities for reducing cosmic-ray induced air showers, muons and night sky background fluctuations. Next-generation arrays with on the order of 100 telescopes offer larger collection areas, provide the possibility to see the air shower from more view points on the ground, have the potential to improve the sensitivity and give additional background suppression. Here we discuss the design of a fast array trigger system that has the potential to perform a real time image analysis allowing substantially improved background rate suppression at the trigger level.

Remote Cherenkov imaging-based quality assurance of a magnetic resonance image-guided radiotherapy system.

PubMed

Andreozzi, Jacqueline M; Mooney, Karen E; Brůža, Petr; Curcuru, Austen; Gladstone, David J; Pogue, Brian W; Green, Olga

2018-06-01

Tools to perform regular quality assurance of magnetic resonance image-guided radiotherapy (MRIgRT) systems should ideally be independent of interference from the magnetic fields. Remotely acquired optical Cherenkov imaging-based dosimetry measurements in water were investigated for this purpose, comparing measures of dose accuracy, temporal dynamics, and overall integrated IMRT delivery. A 40 × 30.5 × 37.5 cm 3 water tank doped with 1 g/L of quinine sulfate was imaged using an intensified charge-coupled device (ICCD) to capture the Cherenkov emission while being irradiated by a commercial MRIgRT system (ViewRay™). The ICCD was placed down-bore at the end of the couch, 4 m from treatment isocenter and behind the 5-Gauss line of the 0.35-T MRI. After establishing optimal camera acquisition settings, square beams of increasing size (4.2 × 4.2 cm 2 , 10.5 × 10.5 cm 2 , and 14.7 × 14.7 cm 2 ) were imaged at 0.93 frames per second, from an individual cobalt-60 treatment head, to develop projection measures related to percent depth dose (PDD) curves and cross beam profiles (CPB). These Cherenkov-derived measurements were compared to ionization chamber (IC) and radiographic film dosimetry data, as well as simulation data from the treatment planning system (TPS). An intensity-modulated radiotherapy (IMRT) commissioning plan from AAPM TG-119 (C4:C-Shape) was also imaged at 2.1 frames per second, and the single linear sum image from 509 s of plan delivery was compared to the dose volume prediction generated by the TPS using gamma index analysis. Analysis of standardized test target images (1024 × 1024 pixels) yielded a pixel resolution of 0.37 mm/pixel. The beam width measured from the Cherenkov image-generated projection CBPs was within 1 mm accuracy when compared to film measurements for all beams. The 502 point measurements (i.e., pixels) of the Cherenkov image-based projection percent depth dose curves (pPDDs) were compared to p

STS-37 Gamma Ray Observatory (GRO) grappled by RMS

NASA Image and Video Library

1991-04-07

Backdropped against the Earth's surface, the Gamma Ray Observatory (GRO) with its solar array (SA) panels deployed is grappled by the remote manipulator system (RMS) during STS-37 systems checkout. GRO's four complement instruments are visible: the Energetic Gamma Ray Experiment Telescope (EGRET) (at the bottom); the Imaging Compton Telescope (COMPTEL) (center); the Oriented Scintillation Spectrometer Experiment (OSSE) (top); and Burst and Transient Source Experiment (BATSE) (on four corners). The view was taken by STS-37 crew through an aft flight deck overhead window.

Gamma-ray Astrophysics with AGILE

DOE Office of Scientific and Technical Information (OSTI.GOV)

Longo, Francesco; Tavani, M.; Barbiellini, G.

2007-07-12

AGILE will explore the gamma-ray Universe with a very innovative instrument combining for the first time a gamma-ray imager and a hard X-ray imager. AGILE will be operational in spring 2007 and it will provide crucial data for the study of Active Galactic Nuclei, Gamma-Ray Bursts, unidentified gamma-ray sources. Galactic compact objects, supernova remnants, TeV sources, and fundamental physics by microsecond timing. The AGILE instrument is designed to simultaneously detect and image photons in the 30 MeV - 50 GeV and 15 - 45 keV energy bands with excellent imaging and timing capabilities, and a large field of view coveringmore » {approx} 1/5 of the entire sky at energies above 30 MeV. A CsI calorimeter is capable of GRB triggering in the energy band 0.3-50 MeV AGILE is now (March 2007) undergoing launcher integration and testing. The PLSV launch is planned in spring 2007. AGILE is then foreseen to be fully operational during the summer of 2007.« less

Theoretical study of the NO gamma system

NASA Technical Reports Server (NTRS)

Langhoff, Stephen R.; Bauschlicher, Charles W., Jr.; Partridge, Harry

1988-01-01

A systematic study of the NO gamma system with level of correlation treatment was carried out using large Gaussian basis sets to determine the potential curves for the X2Pi and A2Sigma(+) states of NO. It is shown that the A2Sigma-X2Pi electronic transition moment (gamma system) increases monotonically with decreasing internuclear distance and that the increase in the moment as r decreases is correlated with the increasing degree of diffuse character in the X2Pi state. The results of a study of the X2Pi and A2Sigma(+) dipole moment functions showed that the X2Pi vibrationally averaged dipole moments and the (1-0) and (2-0) vibration-rotation band intensities agree well with experimental data.

Measurements of neutron distribution in neutrons-gamma-rays mixed field using imaging plate for neutron capture therapy.

PubMed

Tanaka, Kenichi; Endo, Satoru; Hoshi, Masaharu

2010-01-01

The imaging plate (IP) technique is tried to be used as a handy method to measure the spatial neutron distribution via the (157)Gd(n,gamma)(158)Gd reaction for neutron capture therapy (NCT). For this purpose, IP is set in a water phantom and irradiated in a mixed field of neutrons and gamma-rays. The Hiroshima University Radiobiological Research Accelerator is utilized for this experiment. The neutrons are moderated with 20-cm-thick D(2)O to obtain suitable neutron field for NCT. The signal for IP doped with Gd as a neutron-response enhancer is subtracted with its contribution by gamma-rays, which was estimated using IP without Gd. The gamma-ray response of Gd-doped IP to non-Gd IP is set at 1.34, the value measured for (60)Co gamma-rays, in estimating the gamma-ray contribution to Gd-doped IP signal. Then measured distribution of the (157)Gd(n,gamma)(158)Gd reaction rate agrees within 10% with the calculated value based on the method that has already been validated for its reproducibility of Au activation. However, the evaluated distribution of the (157)Gd(n,gamma)(158)Gd reaction rate is so sensitive to gamma-ray energy, e.g. the discrepancy of the (157)Gd(n,gamma)(158)Gd reaction rate between measurement and calculation becomes 30% for the photon energy change from 33keV to 1.253MeV.

A new gamma ray imaging diagnostic for runaway electron studies at DIII-D

NASA Astrophysics Data System (ADS)

Cooper, C. M.; Pace, D. C.; Eidietis, N. W.; Paz-Soldan, C.; Commaux, N.; Shiraki, D.; Hollmann, E. M.; Moyer, R. A.; Risov, V.

2015-11-01

A new Gamma Ray Imager (GRI) is developed to probe the electron distribution function with 2D spatial resolution during runaway electron (RE) experiments at DIII-D. The diagnostic is sensitive to 0.5 - 50 MeV gamma rays, allowing characterization of the RE distribution function evolution during RE dissipation from pellet injection. The GRI consists of a lead ``pinhole camera'' mounted on the midplane with 11x11 counter-current tangential chords 20 cm wide that span the vessel. Up to 30 bismuth germanate (BGO) scintillation detectors capture RE Bremsstrahlung radiation. Detectors operate in current saturation mode at 10 MHz, or the flux is attenuated for Pulse Height Analysis (PHA) capable of discriminating up to ~10k pulses per second. Digital signal processing routines combining shaping filters are performed during PHA to reject noise and record gamma ray energy. The GRI setup and PHA algorithms will be described and initial data from experiments will be presented. Work supported by the US DOE under DE-AC05-00OR22725, DE-FG02-07ER54917 & DE-FC02-04ER54698.

Computed radiography as a gamma ray detector—dose response and applications

NASA Astrophysics Data System (ADS)

O'Keeffe, D. S.; McLeod, R. W.

2004-08-01

Computed radiography (CR) can be used for imaging the spatial distribution of photon emissions from radionuclides. Its wide dynamic range and good response to medium energy gamma rays reduces the need for long exposure times. Measurements of small doses can be performed without having to pre-sensitize the computed radiography plates via an x-ray exposure, as required with screen-film systems. Cassette-based Agfa MD30 and Kodak GP25 CR plates were used in applications involving the detection of gamma ray emissions from technetium-99m and iodine-131. Cassette entrance doses as small as 1 µGy (140 keV gamma rays) produce noisy images, but the images are suitable for applications such as the detection of breaks in radiation protection barriers. A consequence of the gamma ray sensitivity of CR plates is the possibility that some nuclear medicine patients may fog their x-rays if the x-ray is taken soon after their radiopharmaceutical injection. The investigation showed that such fogging is likely to be diffuse.

Study of gamma detection capabilities of the REWARD mobile spectroscopic system

NASA Astrophysics Data System (ADS)

Balbuena, J. P.; Baptista, M.; Barros, S.; Dambacher, M.; Disch, C.; Fiederle, M.; Kuehn, S.; Parzefall, U.

2017-07-01

REWARD is a novel mobile spectroscopic radiation detector system for Homeland Security applications. The system integrates gamma and neutron detection equipped with wireless communication. A comprehensive simulation study on its gamma detection capabilities in different radioactive scenarios is presented in this work. The gamma detection unit consists of a precise energy resolution system based on two stacked (Cd,Zn)Te sensors working in coincidence sum mode. The volume of each of these CZT sensors is 1 cm3. The investigated energy windows used to determine the detection capabilities of the detector correspond to the gamma emissions from 137Cs and 60Co radioactive sources (662 keV and 1173/1333 keV respectively). Monte Carlo and Technology Computer-Aided Design (TCAD) simulations are combined to determine its sensing capabilities for different radiation sources and estimate the limits of detection of the sensing unit as a function of source activity for several shielding materials.

ROBOCAL: An automated NDA (nondestructive analysis) calorimetry and gamma isotopic system

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hurd, J.R.; Powell, W.D.; Ostenak, C.A.

1989-11-01

ROBOCAL, which is presently being developed and tested at Los Alamos National Laboratory, is a full-scale, prototype robotic system for remote calorimetric and gamma-ray analysis of special nuclear materials. It integrates a fully automated, multidrawer, vertical stacker-retriever system for staging unmeasured nuclear materials, and a fully automated gantry robot for computer-based selection and transfer of nuclear materials to calorimetric and gamma-ray measurement stations. Since ROBOCAL is designed for minimal operator intervention, a completely programmed user interface is provided to interact with the automated mechanical and assay systems. The assay system is designed to completely integrate calorimetric and gamma-ray data acquisitionmore » and to perform state-of-the-art analyses on both homogeneous and heterogeneous distributions of nuclear materials in a wide variety of matrices.« less

Development of a novel gamma probe for detecting radiation direction

NASA Astrophysics Data System (ADS)

Pani, R.; Pellegrini, R.; Cinti, M. N.; Longo, M.; Donnarumma, R.; D'Alessio, A.; Borrazzo, C.; Pergola, A.; Ridolfi, S.; De Vincentis, G.

2016-01-01

Spatial localization of radioactive sources is currently a main issue interesting different fields, including nuclear industry, homeland security as well as medical imaging. It is currently achieved using different systems, but the development of technologies for detecting and characterizing radiation is becoming important especially in medical imaging. In this latter field, radiation detection probes have long been used to guide surgery, thanks to their ability to localize and quantify radiopharmaceutical uptake even deep in tissue. Radiolabelled colloid is injected into, or near to, the tumor and the surgeon uses a hand-held radiation detector, the gamma probe, to identify lymph nodes with radiopharmaceutical uptkake. The present work refers to a novel scintigraphic goniometric probe to identify gamma radiation and its direction. The probe incorporates several scintillation crystals joined together in a particular configuration to provide data related to the position of a gamma source. The main technical characteristics of the gamma locator prototype, i.e. sensitivity, spatial resolution and detection efficiency, are investigated. Moreover, the development of a specific procedure applied to the images permits to retrieve the source position with high precision with respect to the currently used gamma probes. The presented device shows a high sensitivity and efficiency to identify gamma radiation taking a short time (from 30 to 60 s). Even though it was designed for applications in radio-guided surgery, it could be used for other purposes, as for example homeland security.

Kernel analysis in TeV gamma-ray selection

NASA Astrophysics Data System (ADS)

Moriarty, P.; Samuelson, F. W.

2000-06-01

We discuss the use of kernel analysis as a technique for selecting gamma-ray candidates in Atmospheric Cherenkov astronomy. The method is applied to observations of the Crab Nebula and Markarian 501 recorded with the Whipple 10 m Atmospheric Cherenkov imaging system, and the results are compared with the standard Supercuts analysis. Since kernel analysis is computationally intensive, we examine approaches to reducing the computational load. Extension of the technique to estimate the energy of the gamma-ray primary is considered. .

Fermi Gamma-Ray Imaging of a Radio Galaxy

DOE PAGES

Abdo, A. A.; Ackermann, M.; Ajello, M.; ...

2010-04-01

The Fermi Gamma-ray Space Telescope has detected the γ-ray glow emanating from the giant radio lobes of the radio galaxy Centaurus A. The resolved γ-ray image shows the lobes clearly separated from the central active source. In contrast to all other active galaxies detected so far in high-energy γ-rays, the lobe flux constitutes a considerable portion (greater than one-half) of the total source emission. The γ-ray emission from the lobes is interpreted as inverse Compton–scattered relic radiation from the cosmic microwave background, with additional contribution at higher energies from the infrared-to-optical extragalactic background light. In conclusion, these measurements provide γ-raymore » constraints on the magnetic field and particle energy content in radio galaxy lobes, as well as a promising method to probe the cosmic relic photon fields.« less

A role for gamma-glutamyl transpeptidase and the amino acid transport system xc- in cystine transport by a human pancreatic duct cell line.

PubMed Central

Sweiry, J H; Sastre, J; Viña, J; Elsässer, H P; Mann, G E

1995-01-01

Tu 8902 cells, cystine uptake is mediated by system xc- (50-60%) and the gamma-glutamyl cycle. Our results provide the first evidence linking gamma-GT with cystine transport in human epithelial cells and are of relevance in view of the importance of cystine as a sulphur amino acid source for GSH synthesis in cells exposed to oxidative stress. Images Figure 1 PMID:7658371

Imaging the Crab nebula when it is flaring in gamma-rays

NASA Astrophysics Data System (ADS)

De Luca, Andrea

2014-10-01

One of the most intriguing results of the gamma-ray instruments currently in orbit has been the detection of powerful flares from the Crab Nebula. Such events, with a recurrence time of about once per year, can be so dramatic to make the system the brightest source in the gamma-ray sky, as it occurred in April 2011. Such a discovery challenges our understanding of how pulsar wind nebulae work and defies current astrophysical models for particle acceleration. With the aim of locating the site(s) of the flares, an ad hoc HST strategy have been put in place to be prepared and react promptly in case of a new brightening in gamma rays. We ask here for a triggered TOO observation of the Crab Nebula with ACS/WFC in case a gamma-ray flare is announced by the Agile and/or the Fermi missions. This TOO is crucial part of a multiwavelength program that we have organized, based on lessons learnt from our follow-up observations of previous flares, including a regular (quarterly) monitoring of the source both in X-rays and optical through a joint Chandra-HST proposal.

Dual-head gamma camera system for intraoperative localization of radioactive seeds

NASA Astrophysics Data System (ADS)

Arsenali, B.; de Jong, H. W. A. M.; Viergever, M. A.; Dickerscheid, D. B. M.; Beijst, C.; Gilhuijs, K. G. A.

2015-10-01

Breast-conserving surgery is a standard option for the treatment of patients with early-stage breast cancer. This form of surgery may result in incomplete excision of the tumor. Iodine-125 labeled titanium seeds are currently used in clinical practice to reduce the number of incomplete excisions. It seems likely that the number of incomplete excisions can be reduced even further if intraoperative information about the location of the radioactive seed is combined with preoperative information about the extent of the tumor. This can be combined if the location of the radioactive seed is established in a world coordinate system that can be linked to the (preoperative) image coordinate system. With this in mind, we propose a radioactive seed localization system which is composed of two static ceiling-suspended gamma camera heads and two parallel-hole collimators. Physical experiments and computer simulations which mimic realistic clinical situations were performed to estimate the localization accuracy (defined as trueness and precision) of the proposed system with respect to collimator-source distance (ranging between 50 cm and 100 cm) and imaging time (ranging between 1 s and 10 s). The goal of the study was to determine whether or not a trueness of 5 mm can be achieved if a collimator-source distance of 50 cm and imaging time of 5 s are used (these specifications were defined by a group of dedicated breast cancer surgeons). The results from the experiments indicate that the location of the radioactive seed can be established with an accuracy of 1.6 mm  ±  0.6 mm if a collimator-source distance of 50 cm and imaging time of 5 s are used (these experiments were performed with a 4.5 cm thick block phantom). Furthermore, the results from the simulations indicate that a trueness of 3.2 mm or less can be achieved if a collimator-source distance of 50 cm and imaging time of 5 s are used (this trueness was achieved for all 14 breast phantoms which

Micro-Slit Collimators for X-Ray/Gamma-Ray Imaging

NASA Technical Reports Server (NTRS)

Appleby, Michael; Fraser, Iain; Klinger, Jill

2011-01-01

A hybrid photochemical-machining process is coupled with precision stack lamination to allow for the fabrication of multiple ultra-high-resolution grids on a single array substrate. In addition, special fixturing and etching techniques have been developed that allow higher-resolution multi-grid collimators to be fabricated. Building on past work of developing a manufacturing technique for fabricating multi-grid, high-resolution coating modulation collimators for arcsecond and subarcsecond x-ray and gamma-ray imaging, the current work reduces the grid pitch by almost a factor of two, down to 22 microns. Additionally, a process was developed for reducing thin, high-Z (tungsten or molybdenum) from the thinnest commercially available foil (25 microns thick) down to approximately equal to 10 microns thick using precisely controlled chemical etching

An independent software system for the analysis of dynamic MR images.

PubMed

Torheim, G; Lombardi, M; Rinck, P A

1997-01-01

A computer system for the manual, semi-automatic, and automatic analysis of dynamic MR images was to be developed on UNIX and personal computer platforms. The system was to offer an integrated and standardized way of performing both image processing and analysis that was independent of the MR unit used. The system consists of modules that are easily adaptable to special needs. Data from MR units or other diagnostic imaging equipment in techniques such as CT, ultrasonography, or nuclear medicine can be processed through the ACR-NEMA/DICOM standard file formats. A full set of functions is available, among them cine-loop visual analysis, and generation of time-intensity curves. Parameters such as cross-correlation coefficients, area under the curve, peak/maximum intensity, wash-in and wash-out slopes, time to peak, and relative signal intensity/contrast enhancement can be calculated. Other parameters can be extracted by fitting functions like the gamma-variate function. Region-of-interest data and parametric values can easily be exported. The system has been successfully tested in animal and patient examinations.

Performance evaluation for pinhole collimators of small gamma camera by MTF and NNPS analysis: Monte Carlo simulation study

NASA Astrophysics Data System (ADS)

Jeon, Hosang; Kim, Hyunduk; Cha, Bo Kyung; Kim, Jong Yul; Cho, Gyuseong; Chung, Yong Hyun; Yun, Jong-Il

2009-06-01

Presently, the gamma camera system is widely used in various medical diagnostic, industrial and environmental fields. Hence, the quantitative and effective evaluation of its imaging performance is essential for design and quality assurance. The National Electrical Manufacturers Association (NEMA) standards for gamma camera evaluation are insufficient to perform sensitive evaluation. In this study, modulation transfer function (MTF) and normalized noise power spectrum (NNPS) will be suggested to evaluate the performance of small gamma camera with changeable pinhole collimators using Monte Carlo simulation. We simulated the system with a cylinder and a disk source, and seven different pinhole collimators from 1- to 4-mm-diameter pinhole with lead. The MTF and NNPS data were obtained from output images and were compared with full-width at half-maximum (FWHM), sensitivity and differential uniformity. In the result, we found that MTF and NNPS are effective and novel standards to evaluate imaging performance of gamma cameras instead of conventional NEMA standards.

A tool to include gamma analysis software into a quality assurance program.

PubMed

Agnew, Christina E; McGarry, Conor K

2016-03-01

To provide a tool to enable gamma analysis software algorithms to be included in a quality assurance (QA) program. Four image sets were created comprising two geometric images to independently test the distance to agreement (DTA) and dose difference (DD) elements of the gamma algorithm, a clinical step and shoot IMRT field and a clinical VMAT arc. The images were analysed using global and local gamma analysis with 2 in-house and 8 commercially available software encompassing 15 software versions. The effect of image resolution on gamma pass rates was also investigated. All but one software accurately calculated the gamma passing rate for the geometric images. Variation in global gamma passing rates of 1% at 3%/3mm and over 2% at 1%/1mm was measured between software and software versions with analysis of appropriately sampled images. This study provides a suite of test images and the gamma pass rates achieved for a selection of commercially available software. This image suite will enable validation of gamma analysis software within a QA program and provide a frame of reference by which to compare results reported in the literature from various manufacturers and software versions. Copyright © 2015. Published by Elsevier Ireland Ltd.

Gamma Band Activity in the Reticular Activating System

PubMed Central

Urbano, Francisco J.; Kezunovic, Nebojsa; Hyde, James; Simon, Christen; Beck, Paige; Garcia-Rill, Edgar

2012-01-01

This review considers recent evidence showing that cells in three regions of the reticular activating system (RAS) exhibit gamma band activity, and describes the mechanisms behind such manifestation. Specifically, we discuss how cells in the mesopontine pedunculopontine nucleus (PPN), intralaminar parafascicular nucleus (Pf), and pontine subcoeruleus nucleus dorsalis (SubCD) all fire in the beta/gamma band range when maximally activated, but no higher. The mechanisms behind this ceiling effect have been recently elucidated. We describe recent findings showing that every cell in the PPN have high-threshold, voltage-dependent P/Q-type calcium channels that are essential, while N-type calcium channels are permissive, to gamma band activity. Every cell in the Pf also showed that P/Q-type and N-type calcium channels are responsible for this activity. On the other hand, every SubCD cell exhibited sodium-dependent subthreshold oscillations. A novel mechanism for sleep–wake control based on well-known transmitter interactions, electrical coupling, and gamma band activity is described. The data presented here on inherent gamma band activity demonstrates the global nature of sleep–wake oscillation that is orchestrated by brainstem–thalamic mechanism, and questions the undue importance given to the hypothalamus for regulation of sleep–wakefulness. The discovery of gamma band activity in the RAS follows recent reports of such activity in other subcortical regions like the hippocampus and cerebellum. We hypothesize that, rather than participating in the temporal binding of sensory events as seen in the cortex, gamma band activity manifested in the RAS may help stabilize coherence related to arousal, providing a stable activation state during waking and paradoxical sleep. Most of our thoughts and actions are driven by pre-conscious processes. We speculate that continuous sensory input will induce gamma band activity in the RAS that could participate in the processes of

Development of polarization-controlled multi-pass Thomson scattering system in the GAMMA 10 tandem mirror

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yoshikawa, M.; Morimoto, M.; Shima, Y.

2012-10-15

In the GAMMA 10 tandem mirror, the typical electron density is comparable to that of the peripheral plasma of torus-type fusion devices. Therefore, an effective method to increase Thomson scattering (TS) signals is required in order to improve signal quality. In GAMMA 10, the yttrium-aluminum-garnet (YAG)-TS system comprises a laser, incident optics, light collection optics, signal detection electronics, and a data recording system. We have been developing a multi-pass TS method for a polarization-based system based on the GAMMA 10 YAG TS. To evaluate the effectiveness of the polarization-based configuration, the multi-pass system was installed in the GAMMA 10 YAG-TSmore » system, which is capable of double-pass scattering. We carried out a Rayleigh scattering experiment and applied this double-pass scattering system to the GAMMA 10 plasma. The integrated scattering signal was made about twice as large by the double-pass system.« less

Using gamma index to flag changes in anatomy during image-guided radiation therapy of head and neck cancer.

PubMed

Schaly, Bryan; Kempe, Jeff; Venkatesan, Varagur; Mitchell, Sylvia; Battista, Jerry J

2017-11-01

During radiation therapy of head and neck cancer, the decision to consider replanning a treatment because of anatomical changes has significant resource implications. We developed an algorithm that compares cone-beam computed tomography (CBCT) image pairs and provides an automatic alert as to when remedial action may be required. Retrospective CBCT data from ten head and neck cancer patients that were replanned during their treatment was used to train the algorithm on when to recommend a repeat CT simulation (re-CT). An additional 20 patients (replanned and not replanned) were used to validate the predictive power of the algorithm. CBCT images were compared in 3D using the gamma index, combining Hounsfield Unit (HU) difference with distance-to-agreement (DTA), where the CBCT study acquired on the first fraction is used as the reference. We defined the match quality parameter (MQP x ) as a difference between the x th percentiles of the failed-pixel histograms calculated from the reference gamma comparison and subsequent comparisons, where the reference gamma comparison is taken from the first two CBCT images acquired during treatment. The decision to consider re-CT was based on three consecutive MQP values being less than or equal to a threshold value, such that re-CT recommendations were within ±3 fractions of the actual re-CT order date for the training cases. Receiver-operator characteristic analysis showed that the best trade-off in sensitivity and specificity was achieved using gamma criteria of 3 mm DTA and 30 HU difference, and the 80 th percentile of the failed-pixel histogram. A sensitivity of 82% and 100% was achieved in the training and validation cases, respectively, with a false positive rate of ~30%. We have demonstrated that gamma analysis of CBCT-acquired anatomy can be used to flag patients for possible replanning in a manner consistent with local clinical practice guidelines. © 2017 The Authors. Journal of Applied Clinical Medical Physics

The analysis of complex mixed-radiation fields using near real-time imaging.

PubMed

Beaumont, Jonathan; Mellor, Matthew P; Joyce, Malcolm J

2014-10-01

A new mixed-field imaging system has been constructed at Lancaster University using the principles of collimation and back projection to passively locate and assess sources of neutron and gamma-ray radiation. The system was set up at the University of Manchester where three radiation sources: (252)Cf, a lead-shielded (241)Am/Be and a (22)Na source were imaged. Real-time discrimination was used to find the respective components of the neutron and gamma-ray fields detected by a single EJ-301 liquid scintillator, allowing separate images of neutron and gamma-ray emitters to be formed. (252)Cf and (22)Na were successfully observed and located in the gamma-ray image; however, the (241)Am/Be was not seen owing to surrounding lead shielding. The (252)Cf and (241)Am/Be neutron sources were seen clearly in the neutron image, demonstrating the advantage of this mixed-field technique over a gamma-ray-only image where the (241)Am/Be source would have gone undetected. © The Author 2014. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

A high resolution liquid xenon imaging telescope for 0.3-10 MeV gamma-ray astrophysics: Construction and initial balloon flights

NASA Technical Reports Server (NTRS)

Aprile, Elena

1994-01-01

An instrument is described which will provide a direct image of gamma-ray line or continuum sources in the energy range 300 keV to 10 MeV. The use of this instrument to study the celestial distribution of the (exp 26)Al isotope by observing the 1.809 MeV deexcitation gamma-ray line is illustrated. The source location accuracy is 2' or better. The imaging telescope is a liquid xenon time projection chamber coupled with a coded aperture mask (LXe-CAT). This instrument will confirm and extend the COMPTEL observations from the Compton Gamma-Ray Observatory (CGRO) with an improved capability for identifying the actual Galactic source or sources of (exp 26)Al, which are currently not known with certainty. sources currently under consideration include red giants on the asymptotic giant branch (AGB), novae, Type 1b or Type 2 supernovae, Wolf-Rayet stars and cosmic-rays interacting in molecular clouds. The instrument could also identify a local source of the celestial 1.809 MeV gamma-ray line, such as a recent nearby supernova.

The Advanced Gamma-ray Imaging System (AGIS): Next-generation Cherenkov telescopes array.

NASA Astrophysics Data System (ADS)

Vassiliev, Vladimir; AGIS Collaboration

2010-03-01

AGIS is a concept for a next-generation ground-based gamma-ray observatory in the energy range from 50 GeV to 200 TeV. AGIS is being designed to have significantly improved sensitivity, angular resolution, and reliability of operation relative to the present generation instruments such as VERITAS and H.E.S.S. The novel technologies of AGIS are expected to enable great advances in the understanding of the populations and physics of sources of high-energy gamma rays in the Milky Way (e.g. SNR, X-ray binaries, dense molecular clouds) and outside the Galaxy (e.g. AGN, GRBs, galaxy clusters, and star-forming galaxies). AGIS will complement and extend the results now being obtained in the GeV range with the Fermi mission providing wide energy coverage, superior angular resolution, and sensitivity to variability on short time scales. AGIS will be a key instrument for identifying and characterizing Fermi LAT sources. In this submission we outline the status of the development of AGIS project, design concept, and principal technologies. As illustrations of the scientific capabilities of AGIS, we review its potential to indirectly search for dark matter and measure cosmological magnetic fields.

dAcquisition setting optimization and quantitative imaging for 124I studies with the Inveon microPET-CT system.

PubMed

Anizan, Nadège; Carlier, Thomas; Hindorf, Cecilia; Barbet, Jacques; Bardiès, Manuel

2012-02-13

Noninvasive multimodality imaging is essential for preclinical evaluation of the biodistribution and pharmacokinetics of radionuclide therapy and for monitoring tumor response. Imaging with nonstandard positron-emission tomography [PET] isotopes such as 124I is promising in that context but requires accurate activity quantification. The decay scheme of 124I implies an optimization of both acquisition settings and correction processing. The PET scanner investigated in this study was the Inveon PET/CT system dedicated to small animal imaging. The noise equivalent count rate [NECR], the scatter fraction [SF], and the gamma-prompt fraction [GF] were used to determine the best acquisition parameters for mouse- and rat-sized phantoms filled with 124I. An image-quality phantom as specified by the National Electrical Manufacturers Association NU 4-2008 protocol was acquired and reconstructed with two-dimensional filtered back projection, 2D ordered-subset expectation maximization [2DOSEM], and 3DOSEM with maximum a posteriori [3DOSEM/MAP] algorithms, with and without attenuation correction, scatter correction, and gamma-prompt correction (weighted uniform distribution subtraction). Optimal energy windows were established for the rat phantom (390 to 550 keV) and the mouse phantom (400 to 590 keV) by combining the NECR, SF, and GF results. The coincidence time window had no significant impact regarding the NECR curve variation. Activity concentration of 124I measured in the uniform region of an image-quality phantom was underestimated by 9.9% for the 3DOSEM/MAP algorithm with attenuation and scatter corrections, and by 23% with the gamma-prompt correction. Attenuation, scatter, and gamma-prompt corrections decreased the residual signal in the cold insert. The optimal energy windows were chosen with the NECR, SF, and GF evaluation. Nevertheless, an image quality and an activity quantification assessment were required to establish the most suitable reconstruction algorithm and

Evaluation of a gamma camera system for the RITS-6 accelerator using the self-magnetic pinch diode

NASA Astrophysics Data System (ADS)

Webb, Timothy J.; Kiefer, Mark L.; Gignac, Raymond; Baker, Stuart A.

2015-08-01

The self-magnetic pinch (SMP) diode is an intense radiographic source fielded on the Radiographic Integrated Test Stand (RITS-6) accelerator at Sandia National Laboratories in Albuquerque, NM. The accelerator is an inductive voltage adder (IVA) that can operate from 2-10 MV with currents up to 160 kA (at 7 MV). The SMP diode consists of an annular cathode separated from a flat anode, holding the bremsstrahlung conversion target, by a vacuum gap. Until recently the primary imaging diagnostic utilized image plates (storage phosphors) which has generally low DQE at these photon energies along with other problems. The benefits of using image plates include a high-dynamic range, good spatial resolution, and ease of use. A scintillator-based X-ray imaging system or "gamma camera" has been fielded in front of RITS and the SMP diode which has been able to provide vastly superior images in terms of signal-to-noise with similar resolution and acceptable dynamic range.

Method and System for Gamma-Ray Localization Induced Spacecraft Navigation Using Celestial Gamma-Ray Sources

NASA Technical Reports Server (NTRS)

Hisamoto, Chuck (Inventor); Arzoumanian, Zaven (Inventor); Sheikh, Suneel I. (Inventor)

2015-01-01

A method and system for spacecraft navigation using distant celestial gamma-ray bursts which offer detectable, bright, high-energy events that provide well-defined characteristics conducive to accurate time-alignment among spatially separated spacecraft. Utilizing assemblages of photons from distant gamma-ray bursts, relative range between two spacecraft can be accurately computed along the direction to each burst's source based upon the difference in arrival time of the burst emission at each spacecraft's location. Correlation methods used to time-align the high-energy burst profiles are provided. The spacecraft navigation may be carried out autonomously or in a central control mode of operation.

Hard X-ray and gamma-ray imaging spectroscopy for the next solar maximum

NASA Technical Reports Server (NTRS)

Hudson, H. S.; Crannell, C. J.; Dennis, B. R.; Spicer, D. S.; Davis, J. M.; Hurford, G. J.; Lin, R. P.

1990-01-01

The objectives and principles are described of a single spectroscopic imaging package that can provide effective imaging in the hard X- and gamma-ray ranges. Called the High-Energy Solar Physics (HESP) mission instrument for solar investigation, the device is based on rotating modulation collimators with germanium semiconductor spectrometers. The instrument is planned to incorporate thick modulation plates, and the range of coverage is discussed. The optics permit the coverage of high-contrast hard X-ray images from small- and medium-sized flares with large signal-to-noise ratios. The detectors allow angular resolution of less than 1 arcsec, time resolution of less than 1 arcsec, and spectral resolution of about 1 keV. The HESP package is considered an effective and important instrument for investigating the high-energy solar events of the near-term future efficiently.

MO-AB-206-02: Testing Gamma Cameras Based On TG177 WG Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Halama, J.

2016-06-15

This education session will cover the physics and operation principles of gamma cameras and PET scanners. The first talk will focus on PET imaging. An overview of the principles of PET imaging will be provided, including positron decay physics, and the transition from 2D to 3D imaging. More recent advances in hardware and software will be discussed, such as time-of-flight imaging, and improvements in reconstruction algorithms that provide for options such as depth-of-interaction corrections. Quantitative applications of PET will be discussed, as well as the requirements for doing accurate quantitation. Relevant performance tests will also be described. Learning Objectives: Bemore » able to describe basic physics principles of PET and operation of PET scanners. Learn about recent advances in PET scanner hardware technology. Be able to describe advances in reconstruction techniques and improvements Be able to list relevant performance tests. The second talk will focus on gamma cameras. The Nuclear Medicine subcommittee has charged a task group (TG177) to develop a report on the current state of physics testing of gamma cameras, SPECT, and SPECT/CT systems. The report makes recommendations for performance tests to be done for routine quality assurance, annual physics testing, and acceptance tests, and identifies those needed satisfy the ACR accreditation program and The Joint Commission imaging standards. The report is also intended to be used as a manual with detailed instructions on how to perform tests under widely varying conditions. Learning Objectives: At the end of the presentation members of the audience will: Be familiar with the tests recommended for routine quality assurance, annual physics testing, and acceptance tests of gamma cameras for planar imaging. Be familiar with the tests recommended for routine quality assurance, annual physics testing, and acceptance tests of SPECT systems. Be familiar with the tests of a SPECT/CT system that include the CT

A low-count reconstruction algorithm for Compton-based prompt gamma imaging

NASA Astrophysics Data System (ADS)

Huang, Hsuan-Ming; Liu, Chih-Chieh; Jan, Meei-Ling; Lee, Ming-Wei

2018-04-01

The Compton camera is an imaging device which has been proposed to detect prompt gammas (PGs) produced by proton–nuclear interactions within tissue during proton beam irradiation. Compton-based PG imaging has been developed to verify proton ranges because PG rays, particularly characteristic ones, have strong correlations with the distribution of the proton dose. However, accurate image reconstruction from characteristic PGs is challenging because the detector efficiency and resolution are generally low. Our previous study showed that point spread functions can be incorporated into the reconstruction process to improve image resolution. In this study, we proposed a low-count reconstruction algorithm to improve the image quality of a characteristic PG emission by pooling information from other characteristic PG emissions. PGs were simulated from a proton beam irradiated on a water phantom, and a two-stage Compton camera was used for PG detection. The results show that the image quality of the reconstructed characteristic PG emission is improved with our proposed method in contrast to the standard reconstruction method using events from only one characteristic PG emission. For the 4.44 MeV PG rays, both methods can be used to predict the positions of the peak and the distal falloff with a mean accuracy of 2 mm. Moreover, only the proposed method can improve the estimated positions of the peak and the distal falloff of 5.25 MeV PG rays, and a mean accuracy of 2 mm can be reached.

Test of Compton camera components for prompt gamma imaging at the ELBE bremsstrahlung beam

NASA Astrophysics Data System (ADS)

Hueso-González, F.; Golnik, C.; Berthel, M.; Dreyer, A.; Enghardt, W.; Fiedler, F.; Heidel, K.; Kormoll, T.; Rohling, H.; Schöne, S.; Schwengner, R.; Wagner, A.; Pausch, G.

2014-05-01

In the context of ion beam therapy, particle range verification is a major challenge for the quality assurance of the treatment. One approach is the measurement of the prompt gamma rays resulting from the tissue irradiation. A Compton camera based on several position sensitive gamma ray detectors, together with an imaging algorithm, is expected to reconstruct the prompt gamma ray emission density map, which is correlated with the dose distribution. At OncoRay and Helmholtz-Zentrum Dresden-Rossendorf (HZDR), a Compton camera setup is being developed consisting of two scatter planes: two CdZnTe (CZT) cross strip detectors, and an absorber consisting of one Lu2SiO5 (LSO) block detector. The data acquisition is based on VME electronics and handled by software developed on the ROOT framework. The setup has been tested at the linear electron accelerator ELBE at HZDR, which is used in this experiment to produce bunched bremsstrahlung photons with up to 12.5 MeV energy and a repetition rate of 13 MHz. Their spectrum has similarities with the shape expected from prompt gamma rays in the clinical environment, and the flux is also bunched with the accelerator frequency. The charge sharing effect of the CZT detector is studied qualitatively for different energy ranges. The LSO detector pixel discrimination resolution is analyzed and it shows a trend to improve for high energy depositions. The time correlation between the pulsed prompt photons and the measured detector signals, to be used for background suppression, exhibits a time resolution of 3 ns FWHM for the CZT detector and of 2 ns for the LSO detector. A time walk correction and pixel-wise calibration is applied for the LSO detector, whose resolution improves up to 630 ps. In conclusion, the detector setup is suitable for time-resolved background suppression in pulsed clinical particle accelerators. Ongoing tasks are the quantitative comparison with simulations and the test of imaging algorithms. Experiments at proton

Image contrast enhancement with brightness preservation using an optimal gamma correction and weighted sum approach

NASA Astrophysics Data System (ADS)

Jiang, G.; Wong, C. Y.; Lin, S. C. F.; Rahman, M. A.; Ren, T. R.; Kwok, Ngaiming; Shi, Haiyan; Yu, Ying-Hao; Wu, Tonghai

2015-04-01

The enhancement of image contrast and preservation of image brightness are two important but conflicting objectives in image restoration. Previous attempts based on linear histogram equalization had achieved contrast enhancement, but exact preservation of brightness was not accomplished. A new perspective is taken here to provide balanced performance of contrast enhancement and brightness preservation simultaneously by casting the quest of such solution to an optimization problem. Specifically, the non-linear gamma correction method is adopted to enhance the contrast, while a weighted sum approach is employed for brightness preservation. In addition, the efficient golden search algorithm is exploited to determine the required optimal parameters to produce the enhanced images. Experiments are conducted on natural colour images captured under various indoor, outdoor and illumination conditions. Results have shown that the proposed method outperforms currently available methods in contrast to enhancement and brightness preservation.

TU-H-206-01: An Automated Approach for Identifying Geometric Distortions in Gamma Cameras

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mann, S; Nelson, J; Samei, E

2016-06-15

Purpose: To develop a clinically-deployable, automated process for detecting artifacts in routine nuclear medicine (NM) quality assurance (QA) bar phantom images. Methods: An artifact detection algorithm was created to analyze bar phantom images as part of an ongoing QA program. A low noise, high resolution reference image was acquired from an x-ray of the bar phantom with a Philips Digital Diagnost system utilizing image stitching. NM bar images, acquired for 5 million counts over a 512×512 matrix, were registered to the template image by maximizing mutual information (MI). The MI index was used as an initial test for artifacts; lowmore » values indicate an overall presence of distortions regardless of their spatial location. Images with low MI scores were further analyzed for bar linearity, periodicity, alignment, and compression to locate differences with respect to the template. Findings from each test were spatially correlated and locations failing multiple tests were flagged as potential artifacts requiring additional visual analysis. The algorithm was initially deployed for GE Discovery 670 and Infinia Hawkeye gamma cameras. Results: The algorithm successfully identified clinically relevant artifacts from both systems previously unnoticed by technologists performing the QA. Average MI indices for artifact-free images are 0.55. Images with MI indices < 0.50 have shown 100% sensitivity and specificity for artifact detection when compared with a thorough visual analysis. Correlation of geometric tests confirms the ability to spatially locate the most likely image regions containing an artifact regardless of initial phantom orientation. Conclusion: The algorithm shows the potential to detect gamma camera artifacts that may be missed by routine technologist inspections. Detection and subsequent correction of artifacts ensures maximum image quality and may help to identify failing hardware before it impacts clinical workflow. Going forward, the algorithm is

AGATE: A High Energy Gamma-Ray Telescope Using Drift Chambers

NASA Astrophysics Data System (ADS)

Mukherjee, R.; Dingus, B. L.; Esposito, J. A.; Bertsch, D. L.; Cuddapah, R.; Fichtel, C. E.; Hartman, R. C.; Hunter, S. D.; Thompson, D. J.

1996-01-01

The exciting results from the highly successful Energetic Gamma-Ray Experiment Telescope (EGRET) instrument on the Compton Gamma-Ray Observatory (CGRO) has contributed significantly to increasing our understanding of high energy gamma-ray astronomy. A follow-on mission to EGRET is needed to continue these scientific advances as well as to address the several new scientific questions raised by EGRET. Here we describe the work being done on the development of the Advanced Gamma-Ray Astronomy Telescope Experiment (AGATE), visualized as the successor to EGRET. In order to achieve the scientific goals, AGATE will have higher sensitivity than EGRET in the energy range 30 MeV to 30 GeV, larger effective area, better angular resolution, and an extended low and high energy range. In its design, AGATE will follow the tradition of the earlier gamma-ray telescopes, SAS-2, COS B, and EGRET, and will have the same four basic components of an anticoincidence system, directional coincidence system, track imaging, and energy measurement systems. However, due to its much larger size, AGATE will use drift chambers as its track imaging system rather than the spark chambers used by EGRET. Drift chambers are an obvious choice as they have less deadtime per event, better spatial resolution, and are relatively easy and inexpensive to build. Drift chambers have low power requirements, so that many layers of drift chambers can be included. To test the feasibility of using drift chambers, we have constructed a prototype instrument consisting of a stack of sixteen 1/2m × 1/2m drift chambers and have measured the spatial resolution using atmospheric muons. The results on the drift chamber performance in the laboratory are presented here.

Performance analysis of OOK-based FSO systems in Gamma-Gamma turbulence with imprecise channel models

NASA Astrophysics Data System (ADS)

Feng, Jianfeng; Zhao, Xiaohui

2017-11-01

For an FSO communication system with imprecise channel model, we investigate its system performance based on outage probability, average BEP and ergodic capacity. The exact FSO links are modeled as Gamma-Gamma fading channel in consideration of both atmospheric turbulence and pointing errors, and the imprecise channel model is treated as the superposition of exact channel gain and a Gaussian random variable. After we derive the PDF, CDF and nth moment of the imprecise channel gain, and based on these statistics the expressions for the outage probability, the average BEP and the ergodic capacity in terms of the Meijer's G functions are obtained. Both numerical and analytical results are presented. The simulation results show that the communication performance deteriorates in the imprecise channel model, and approaches to the exact performance curves as the channel model becomes accurate.

Design study of multi-imaging plate system for BNCT irradiation field at Kyoto university reactor.

PubMed

Tanaka, Kenichi; Sakurai, Yoshinori; Kajimoto, Tsuyoshi; Tanaka, Hiroki; Takata, Takushi; Endo, Satoru

2016-09-01

The converter configuration for a multi-imaging plate system was investigated for the application of quality assurance in the irradiation field profile for boron neutron capture therapy. This was performed by the simulation calculation using the PHITS code in the fields at the Heavy Water Neutron Irradiation Facility of Kyoto University Reactor. The converter constituents investigated were carbon for gamma rays, and polyethylene with and without LiF at varied (6)Li concentration for thermal, epithermal, and fast neutrons. Consequently, potential combinations of the converters were found for two components, gamma rays and thermal neutrons, for the standard thermal neutron mode and three components of gamma rays, epithermal neutrons, and thermal or fast neutrons, for the standard mixed or epithermal neutron modes, respectively. Copyright © 2016 Elsevier Ltd. All rights reserved.

Technology Needs for Gamma Ray Astronomy

NASA Technical Reports Server (NTRS)

Gehrels, Neil

2011-01-01

Gamma ray astronomy is currently in an exciting period of multiple missions and a wealth of data. Results from INTEGRAL, Fermi, AGILE, Suzaku and Swift are making large contributions to our knowledge of high energy processes in the universe. The advances are due to new detector and imaging technologies. The steps to date have been from scintillators to solid state detectors for sensors and from light buckets to coded aperture masks and pair telescopes for imagers. A key direction for the future is toward focusing telescopes pushing into the hard X-ray regime and Compton telescopes and pair telescopes with fine spatial resolution for medium and high energy gamma rays. These technologies will provide finer imaging of gamma-ray sources. Importantly, they will also enable large steps forward in sensitivity by reducing background.

The Topo-trigger: a new concept of stereo trigger system for imaging atmospheric Cherenkov telescopes

NASA Astrophysics Data System (ADS)

López-Coto, R.; Mazin, D.; Paoletti, R.; Blanch Bigas, O.; Cortina, J.

2016-04-01

Imaging atmospheric Cherenkov telescopes (IACTs) such as the Major Atmospheric Gamma-ray Imaging Cherenkov (MAGIC) telescopes endeavor to reach the lowest possible energy threshold. In doing so the trigger system is a key element. Reducing the trigger threshold is hampered by the rapid increase of accidental triggers generated by ambient light (the so-called Night Sky Background NSB). In this paper we present a topological trigger, dubbed Topo-trigger, which rejects events on the basis of their relative orientation in the telescope cameras. We have simulated and tested the trigger selection algorithm in the MAGIC telescopes. The algorithm was tested using MonteCarlo simulations and shows a rejection of 85% of the accidental stereo triggers while preserving 99% of the gamma rays. A full implementation of this trigger system would achieve an increase in collection area between 10 and 20% at the energy threshold. The analysis energy threshold of the instrument is expected to decrease by ~ 8%. The selection algorithm was tested on real MAGIC data taken with the current trigger configuration and no γ-like events were found to be lost.

Gamma-resonance Contraband Detection using a high current tandem accelerator

DOE Office of Scientific and Technical Information (OSTI.GOV)

Milton, B. F.; Beis, J.; Dale, D.

1999-04-26

TRIUMF and Northrop Grumman have developed a new system for the detection of concealed explosives and drugs. This Contraband Detection System (CDS) is based on the resonant absorption by {sup 14}N of gammas produced using {sup 13}C(p,{gamma}){sup 14}N. The chosen reaction uses protons at 1.75 MeV and the gammas have an energy of 9.17 MeV. By measuring both the resonant and the non-resonant absorption using detectors with good spatial resolution, and applying standard tomographic techniques, we are able to produce 3D images of both the nitrogen partial density and the total density. The images together may be utilized with considerablemore » confidence to determine if small amounts of nitrogen based explosives, heroin or cocaine are present in the interrogated containers. Practical Gamma Resonant Absorption (GRA) scanning requires an intense source of protons. However this proton source must also be very stable, have low energy spread, and have good spatial definition. These demands suggested a tandem as the accelerator of choice. We have therefore constructed a 2 MeV H{sup -} tandem optimized for high current (10 mA) operation, while minimizing the overall size of the accelerator. This has required several special innovations which will be presented in the paper. We will also present initial commissioning results.« less

Nano drug delivery systems and gamma radiation sterilization.

PubMed

Sakar, F; Özer, A Y; Erdogan, S; Ekizoglu, M; Kart, D; Özalp, M; Colak, S; Zencir, Y

2017-09-01

In recent years, drug delivery systems such as liposomes and microparticles have been used in clinic for the treatment of different diseases and from a regulatory point of view, a parenterally applied drug and drug delivery systems must be sterile and pyrogen free. Radiation sterilization is a method recognized by pharmacopoeias to achieve sterility criteria of parenterals. It has the ability to kill microorganisms in therapeutic products. The ability of, however, irradiation might also affect the performance of drug delivery systems. One of the most critical points is irradiation dose, because certain undesirable chemical and physical changes may accompany with the irradiation, especially with the traditionally applied dose of 25 kGy. Its ionizing property may cause fragmentation of covalent bond. The care must be paid to the applied dose. In this research, the effects of gamma irradiation on different drug delivery systems such as chitosan microparticles, liposomes, niosomes and sphingosomes were investigated. According to the experimental data, it can be concluded that gamma irradiation can be a suitable sterilization technique for liposome, niosome and sphingosome dispersions. When all irradiated drug carrier systems were taken into consideration, chitosan glutamate microparticles were found as the most radioresistant drug delivery system among the others.

Medical Imaging System

NASA Technical Reports Server (NTRS)

1991-01-01

The MD Image System, a true-color image processing system that serves as a diagnostic aid and tool for storage and distribution of images, was developed by Medical Image Management Systems, Huntsville, AL, as a "spinoff from a spinoff." The original spinoff, Geostar 8800, developed by Crystal Image Technologies, Huntsville, incorporates advanced UNIX versions of ELAS (developed by NASA's Earth Resources Laboratory for analysis of Landsat images) for general purpose image processing. The MD Image System is an application of this technology to a medical system that aids in the diagnosis of cancer, and can accept, store and analyze images from other sources such as Magnetic Resonance Imaging.

Human adaptive immune system Rag2-/-gamma(c)-/- mice.

PubMed

Chicha, Laurie; Tussiwand, Roxane; Traggiai, Elisabetta; Mazzucchelli, Luca; Bronz, Lucio; Piffaretti, Jean-Claude; Lanzavecchia, Antonio; Manz, Markus G

2005-06-01

Although many biologic principles are conserved in mice and humans, species-specific differences exist, for example, in susceptibility and response to pathogens, that often do not allow direct implementation of findings in experimental mice to humans. Research in humans, however, for ethical and practical reasons, is largely restricted to in vitro assays that lack components and the complexity of a living organism. To nevertheless study the human hematopoietic and immune system in vivo, xenotransplantation assays have been developed that substitute human components to small animals. Here, we summarize our recent findings that transplantation of human cord blood CD34(+) cells to newborn Rag2(-/-)gamma(c)(-/-) mice leads to de novo development of major functional components of the human adaptive immune system. These human adaptive immune system Rag2(-/-)gamma(c)(-/-) (huAIS-RG) mice can now be used as a technically straightforward preclinical model to evaluate in vivo human adaptive immune system development as well as immune responses, for example, to vaccines or live infectious pathogens.

System to quantify gamma-ray radial energy deposition in semiconductor detectors

DOEpatents

Kammeraad, Judith E.; Blair, Jerome J.

2001-01-01

A system for measuring gamma-ray radial energy deposition is provided for use in conjunction with a semiconductor detector. The detector comprises two electrodes and a detector material, and defines a plurality of zones within the detecting material in parallel with the two electrodes. The detector produces a charge signal E(t) when a gamma-ray interacts with the detector. Digitizing means are provided for converting the charge signal E(t) into a digitized signal. A computational means receives the digitized signal and calculates in which of the plurality of zones the gamma-ray deposited energy when interacting with the detector. The computational means produces an output indicating the amount of energy deposited by the gamma-ray in each of the plurality of zones.

Attributes from NMIS Time Coincidence, Fast-Neutron Imaging, Fission Mapping, And Gamma-Ray Spectrometry Data

DOE Office of Scientific and Technical Information (OSTI.GOV)

Swift, Alicia L; Grogan, Brandon R; Mullens, James Allen

This work tests a systematic procedure for analyzing data acquired by the Nuclear Materials Identification System (NMIS) at Oak Ridge National Laboratory with fast-neutron imaging and high-purity germanium (HPGe) gamma spectrometry capabilities. NMIS has been under development by the US Department of Energy Office of Nuclear Verification since the mid-1990s, and prior to that by the National Nuclear Security Administration Y-12 National Security Complex, with NMIS having been used at Y-12 for template matching to confirm inventory and receipts. In this present work, a complete set of NMIS time coincidence, fast-neutron imaging, fission mapping, and HPGe gamma-ray spectrometry data wasmore » obtained from Monte Carlo simulations for a configuration of fissile and nonfissile materials. The data were then presented for analysis to someone who had no prior knowledge of the unknown object to accurately determine the description of the object by applying the previously-mentioned procedure to the simulated data. The best approximation indicated that the unknown object was composed of concentric cylinders: a void inside highly enriched uranium (HEU) (84.7 {+-} 1.9 wt % {sup 235}U), surrounded by depleted uranium, surrounded by polyethylene. The final estimation of the unknown object had the correct materials and geometry, with error in the radius estimates of material regions varying from 1.58% at best and 4.25% at worst; error in the height estimates varied from 2% to 12%. The error in the HEU enrichment estimate was 5.9 wt % (within 2.5{sigma} of the true value). The accuracies of the determinations could be adequate for arms control applications. Future work will apply this iterative reconstructive procedure to other unknown objects to further test and refine it.« less

The Advanced Gamma-ray Imaging System (AGIS): Real Time Stereoscopic Array Trigger

NASA Astrophysics Data System (ADS)

Byrum, K.; Anderson, J.; Buckley, J.; Cundiff, T.; Dawson, J.; Drake, G.; Duke, C.; Haberichter, B.; Krawzcynski, H.; Krennrich, F.; Madhavan, A.; Schroedter, M.; Smith, A.

2009-05-01

Future large arrays of Imaging Atmospheric Cherenkov telescopes (IACTs) such as AGIS and CTA are conceived to comprise of 50 - 100 individual telescopes each having a camera with 10**3 to 10**4 pixels. To maximize the capabilities of such IACT arrays with a low energy threshold, a wide field of view and a low background rate, a sophisticated array trigger is required. We describe the design of a stereoscopic array trigger that calculates image parameters and then correlates them across a subset of telescopes. Fast Field Programmable Gate Array technology allows to use lookup tables at the array trigger level to form a real-time pattern recognition trigger tht capitalizes on the multiple view points of the shower at different shower core distances. A proof of principle system is currently under construction. It is based on 400 MHz FPGAs and the goal is for camera trigger rates of up to 10 MHz and a tunable cosmic-ray background suppression at the array level.

High resolution x-ray and gamma ray imaging using diffraction lenses with mechanically bent crystals

DOEpatents

Smither, Robert K [Hinsdale, IL

2008-12-23

A method for high spatial resolution imaging of a plurality of sources of x-ray and gamma-ray radiation is provided. High quality mechanically bent diffracting crystals of 0.1 mm radial width are used for focusing the radiation and directing the radiation to an array of detectors which is used for analyzing their addition to collect data as to the location of the source of radiation. A computer is used for converting the data to an image. The invention also provides for the use of a multi-component high resolution detector array and for narrow source and detector apertures.

IR observations in gamma-ray blazars

NASA Technical Reports Server (NTRS)

Mahoney, W. A.; Gautier, T. N.; Ressler, M. E.; Wallyn, P.; Durouchoux, P.; Higdon, J. C.

1997-01-01

The infrared photometric and spectral observation of five gamma ray blazars in coordination with the energetic gamma ray experiment telescope (EGRET) onboard the Compton Gamma Ray Observatory is reported. The infrared measurements were made with a Cassegrain infrared camera and the mid-infrared large well imager at the Mt. Palomar 5 m telescope. The emphasis is on the three blazars observed simultaneously by EGRET and the ground-based telescope during viewing period 519. In addition to the acquisition of broadband spectral measurements for direct correlation with the 100 MeV EGRET observations, near infrared images were obtained, enabling a search for intra-day variability to be carried out.

A comprehensive experimental characterization of the iPIX gamma imager

NASA Astrophysics Data System (ADS)

Amgarou, K.; Paradiso, V.; Patoz, A.; Bonnet, F.; Handley, J.; Couturier, P.; Becker, F.; Menaa, N.

2016-08-01

The results of more than 280 different experiments aimed at exploring the main features and performances of a newly developed gamma imager, called iPIX, are summarized in this paper. iPIX is designed to quickly localize radioactive sources while estimating the ambient dose equivalent rate at the measurement point. It integrates a 1 mm thick CdTe detector directly bump-bonded to a Timepix chip, a tungsten coded-aperture mask, and a mini RGB camera. It also represents a major technological breakthrough in terms of lightness, compactness, usability, response sensitivity, and angular resolution. As an example of its key strengths, an 241Am source with a dose rate of only few nSv/h can be localized in less than one minute.

Segmentation and intensity estimation of microarray images using a gamma-t mixture model.

PubMed

Baek, Jangsun; Son, Young Sook; McLachlan, Geoffrey J

2007-02-15

We present a new approach to the analysis of images for complementary DNA microarray experiments. The image segmentation and intensity estimation are performed simultaneously by adopting a two-component mixture model. One component of this mixture corresponds to the distribution of the background intensity, while the other corresponds to the distribution of the foreground intensity. The intensity measurement is a bivariate vector consisting of red and green intensities. The background intensity component is modeled by the bivariate gamma distribution, whose marginal densities for the red and green intensities are independent three-parameter gamma distributions with different parameters. The foreground intensity component is taken to be the bivariate t distribution, with the constraint that the mean of the foreground is greater than that of the background for each of the two colors. The degrees of freedom of this t distribution are inferred from the data but they could be specified in advance to reduce the computation time. Also, the covariance matrix is not restricted to being diagonal and so it allows for nonzero correlation between R and G foreground intensities. This gamma-t mixture model is fitted by maximum likelihood via the EM algorithm. A final step is executed whereby nonparametric (kernel) smoothing is undertaken of the posterior probabilities of component membership. The main advantages of this approach are: (1) it enjoys the well-known strengths of a mixture model, namely flexibility and adaptability to the data; (2) it considers the segmentation and intensity simultaneously and not separately as in commonly used existing software, and it also works with the red and green intensities in a bivariate framework as opposed to their separate estimation via univariate methods; (3) the use of the three-parameter gamma distribution for the background red and green intensities provides a much better fit than the normal (log normal) or t distributions; (4) the

Real-time gamma imaging of technetium transport through natural and engineered porous materials for radioactive waste disposal.

PubMed

Corkhill, Claire L; Bridge, Jonathan W; Chen, Xiaohui C; Hillel, Phil; Thornton, Steve F; Romero-Gonzalez, Maria E; Banwart, Steven A; Hyatt, Neil C

2013-12-03

We present a novel methodology for determining the transport of technetium-99m, a γ-emitting metastable isomer of (99)Tc, through quartz sand and porous media relevant to the disposal of nuclear waste in a geological disposal facility (GDF). Quartz sand is utilized as a model medium, and the applicability of the methodology to determine radionuclide transport in engineered backfill cement is explored using the UK GDF candidate backfill cement, Nirex Reference Vault Backfill (NRVB), in a model system. Two-dimensional distributions in (99m)Tc activity were collected at millimeter-resolution using decay-corrected gamma camera images. Pulse-inputs of ~20 MBq (99m)Tc were introduced into short (<10 cm) water-saturated columns at a constant flow of 0.33 mL min(-1). Changes in calibrated mass distribution of (99m)Tc at 30 s intervals, over a period of several hours, were quantified by spatial moments analysis. Transport parameters were fitted to the experimental data using a one-dimensional convection-dispersion equation, yielding transport properties for this radionuclide in a model GDF environment. These data demonstrate that (99)Tc in the pertechnetate form (Tc(VII)O4(-)) does not sorb to cement backfill during transport under model conditions, resulting in closely conservative transport behavior. This methodology represents a quantitative development of radiotracer imaging and offers the opportunity to conveniently and rapidly characterize transport of gamma-emitting isotopes in opaque media, relevant to the geological disposal of nuclear waste and potentially to a wide variety of other subsurface environments.

Real-Time Gamma Imaging of Technetium Transport through Natural and Engineered Porous Materials for Radioactive Waste Disposal

PubMed Central

2013-01-01

We present a novel methodology for determining the transport of technetium-99m, a γ-emitting metastable isomer of 99Tc, through quartz sand and porous media relevant to the disposal of nuclear waste in a geological disposal facility (GDF). Quartz sand is utilized as a model medium, and the applicability of the methodology to determine radionuclide transport in engineered backfill cement is explored using the UK GDF candidate backfill cement, Nirex Reference Vault Backfill (NRVB), in a model system. Two-dimensional distributions in 99mTc activity were collected at millimeter-resolution using decay-corrected gamma camera images. Pulse-inputs of ∼20 MBq 99mTc were introduced into short (<10 cm) water-saturated columns at a constant flow of 0.33 mL min–1. Changes in calibrated mass distribution of 99mTc at 30 s intervals, over a period of several hours, were quantified by spatial moments analysis. Transport parameters were fitted to the experimental data using a one-dimensional convection–dispersion equation, yielding transport properties for this radionuclide in a model GDF environment. These data demonstrate that 99Tc in the pertechnetate form (Tc(VII)O4–) does not sorb to cement backfill during transport under model conditions, resulting in closely conservative transport behavior. This methodology represents a quantitative development of radiotracer imaging and offers the opportunity to conveniently and rapidly characterize transport of gamma-emitting isotopes in opaque media, relevant to the geological disposal of nuclear waste and potentially to a wide variety of other subsurface environments. PMID:24147650

21 CFR 862.1360 - Gamma-glutamyl transpeptidase and isoenzymes test system.

Code of Federal Regulations, 2012 CFR

2012-04-01

... HUMAN SERVICES (CONTINUED) MEDICAL DEVICES CLINICAL CHEMISTRY AND CLINICAL TOXICOLOGY DEVICES Clinical Chemistry Test Systems § 862.1360 Gamma-glutamyl transpeptidase and isoenzymes test system. (a...

21 CFR 862.1360 - Gamma-glutamyl transpeptidase and isoenzymes test system.

Code of Federal Regulations, 2014 CFR

2014-04-01

... HUMAN SERVICES (CONTINUED) MEDICAL DEVICES CLINICAL CHEMISTRY AND CLINICAL TOXICOLOGY DEVICES Clinical Chemistry Test Systems § 862.1360 Gamma-glutamyl transpeptidase and isoenzymes test system. (a...

Advanced image fusion algorithms for Gamma Knife treatment planning. Evaluation and proposal for clinical use.

PubMed

Apostolou, N; Papazoglou, Th; Koutsouris, D

2006-01-01

Image fusion is a process of combining information from multiple sensors. It is a useful tool implemented in the treatment planning programme of Gamma Knife Radiosurgery. In this paper we evaluate advanced image fusion algorithms for Matlab platform and head images. We develop nine level grayscale image fusion methods: average, principal component analysis (PCA), discrete wavelet transform (DWT) and Laplacian, filter - subtract - decimate (FSD), contrast, gradient, morphological pyramid and a shift invariant discrete wavelet transform (SIDWT) method in Matlab platform. We test these methods qualitatively and quantitatively. The quantitative criteria we use are the Root Mean Square Error (RMSE), the Mutual Information (MI), the Standard Deviation (STD), the Entropy (H), the Difference Entropy (DH) and the Cross Entropy (CEN). The qualitative are: natural appearance, brilliance contrast, presence of complementary features and enhancement of common features. Finally we make clinically useful suggestions.

Insights into electron and ion acceleration and transport from x-ray and gamma-ray imaging spectroscopy

NASA Astrophysics Data System (ADS)

Hurford, Gordon J.; Krucker, Samuel

The previous solar maximum has featured high resolution imaging/spectroscopy observations at hard x-ray and gamma-ray energies by the Reuven Ramaty High Energy Solar/Spectroscopic Imager (RHESSI). Highlights of these observations will be reviewed, along with their impli-cations for our understanding of ion and electron acceleration and transport processes. The results to date have included new insights into the location of the acceleration region and the thick target model, a new appreciation of the significance of x-ray albedo, observation of coronal gamma-ray sources and their implications for electron trapping, and indications of differences in the acceleration and transport between electrons and ions. The role of RHESSI's observational strengths and weaknesses in determining the character of its scientific results will also be discussed and used to identify what aspects of the acceleration and transport processes must await the next generation of instrumentation. The extent to which new instrumentation now under development, such as Solar Orbiter/STIX, GRIPS, and FOXSI, can address these open issues will be outlined.

A system for the measurement of delayed neutrons and gammas from special nuclear materials

DOE PAGES

Andrews, M. T.; Corcoran, E. C.; Goorley, J. T.; ...

2014-11-27

The delayed neutron counting (DNC) system at the Royal Military College of Canada has been upgraded to accommodate concurrent delayed neutron and gamma measurements. This delayed neutron and gamma counting (DNGC) system uses a SLOWPOKE-2 reactor to irradiate fissile materials before their transfer to a counting arrangement consisting of six ³He and one HPGe detector. The application of this system is demonstrated in an example where delayed neutron and gamma emissions are used in complement to examine ²³³U content and determine fissile mass with an average relative error and accuracy of -2.2 and 1.5 %, respectively.

Gate simulation of Compton Ar-Xe gamma-camera for radionuclide imaging in nuclear medicine

NASA Astrophysics Data System (ADS)

Dubov, L. Yu; Belyaev, V. N.; Berdnikova, A. K.; Bolozdynia, A. I.; Akmalova, Yu A.; Shtotsky, Yu V.

2017-01-01

Computer simulations of cylindrical Compton Ar-Xe gamma camera are described in the current report. Detection efficiency of cylindrical Ar-Xe Compton camera with internal diameter of 40 cm is estimated as1-3%that is 10-100 times higher than collimated Anger’s camera. It is shown that cylindrical Compton camera can image Tc-99m radiotracer distribution with uniform spatial resolution of 20 mm through the whole field of view.

SU-E-T-563: Multi-Fraction Stereotactic Radiosurgery with Extend System of Gamma Knife: Treatment Verification Using Indigenously Designed Patient Simulating Multipurpose Phantom

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bisht, R; Kale, S; Gopishankar, N

2015-06-15

Purpose: Aim of the study is to evaluate mechanical and radiological accuracy of multi-fraction regimen and validate Gamma knife based fractionation using newly developed patient simulating multipurpose phantom. Methods: A patient simulating phantom was designed to verify fractionated treatments with extend system (ES) of Gamma Knife however it could be used to validate other radiotherapy procedures as well. The phantom has options to insert various density material plugs and mini CT/MR distortion phantoms to analyze the quality of stereotactic imaging. An additional thorax part designed to predict surface doses at various organ sites. The phantom was positioned using vacuum headmore » cushion and patient control unit for imaging and treatment. The repositioning check tool (RCT) was used to predict phantom positioning under ES assembly. The phantom with special inserts for film in axial, coronal and sagittal plane were scanned with X-Ray CT and the acquired images were transferred to treatment planning system (LGP 10.1). The focal precession test was performed with 4mm collimator and an experimental plan of four 16mm collimator shots was prepared for treatment verification of multi-fraction regimen. The prescription dose of 5Gy per fraction was delivered in four fractions. Each fraction was analyzed using EBT3 films scanned with EPSON 10000XL Scanner. Results: The measurement of 38 RCT points showed an overall positional accuracy of 0.28mm. The mean deviation of 0.28% and 0.31 % were calculated as CT and MR image distortion respectively. The radiological focus accuracy test showed its deviation from mechanical center point of 0.22mm. The profile measurement showed close agreement between TPS planned and film measured dose. At tolerance criteria of 1%/1mm gamma index analysis showed a pass rate of > 95%. Conclusion: Our results show that the newly developed multipurpose patient simulating phantom is highly suitable for the verification of fractionated stereotactic

A library least-squares approach for scatter correction in gamma-ray tomography

NASA Astrophysics Data System (ADS)

Meric, Ilker; Anton Johansen, Geir; Valgueiro Malta Moreira, Icaro

2015-03-01

Scattered radiation is known to lead to distortion in reconstructed images in Computed Tomography (CT). The effects of scattered radiation are especially more pronounced in non-scanning, multiple source systems which are preferred for flow imaging where the instantaneous density distribution of the flow components is of interest. In this work, a new method based on a library least-squares (LLS) approach is proposed as a means of estimating the scatter contribution and correcting for this. The validity of the proposed method is tested using the 85-channel industrial gamma-ray tomograph previously developed at the University of Bergen (UoB). The results presented here confirm that the LLS approach can effectively estimate the amounts of transmission and scatter components in any given detector in the UoB gamma-ray tomography system.

A versatile calibration procedure for portable coded aperture gamma cameras and RGB-D sensors

NASA Astrophysics Data System (ADS)

Paradiso, V.; Crivellaro, A.; Amgarou, K.; de Lanaute, N. Blanc; Fua, P.; Liénard, E.

2018-04-01

The present paper proposes a versatile procedure for the geometrical calibration of coded aperture gamma cameras and RGB-D depth sensors, using only one radioactive point source and a simple experimental set-up. Calibration data is then used for accurately aligning radiation images retrieved by means of the γ-camera with the respective depth images computed with the RGB-D sensor. The system resulting from such a combination is thus able to retrieve, automatically, the distance of radioactive hotspots by means of pixel-wise mapping between gamma and depth images. This procedure is of great interest for a wide number of applications, ranging from precise automatic estimation of the shape and distance of radioactive objects to Augmented Reality systems. Incidentally, the corresponding results validated the choice of a perspective design model for a coded aperture γ-camera.

The Gamma Ray Imaging Detector of the AGILE satellite: A novel application of silicon trackers for detection of astrophysics high-energy photons

NASA Astrophysics Data System (ADS)

Rappoldi, Andrea; AGILE Collaboration

2009-10-01

AGILE is a project of the Italian Space Agency (ASI) Scientific Program dedicated to Gamma ray astrophysics. It is designed to be a very light and compact instrument, capable of photon detections and imaging in both the 30 MeV-50 GeV and 18-60 keV energy ranges, with a large field of view (FOV is ˜3 and ˜1 sr, respectively). The core of the instrument (launched on April 23, 2007 from the Indian Space Research Organization's launch facility) is represented by the Gamma Ray Imaging Detector (GRID), which is a silicon tracker developed by the Italian National Institute of Nuclear Physics (INFN), with a spatial resolution of ˜40 μm. The GRID performances have been studied by means of a GEANT Montecarlo, and tested with a dedicated calibration campaign using the tagged gamma beam available at Beam Test Facility (BTF) of INFN Frascati Laboratory.

Image intensifier-based volume tomographic angiography imaging system: system evaluation

NASA Astrophysics Data System (ADS)

Ning, Ruola; Wang, Xiaohui; Shen, Jianjun; Conover, David L.

1995-05-01

An image intensifier-based rotational volume tomographic angiography imaging system has been constructed. The system consists of an x-ray tube and an image intensifier that are separately mounted on a gantry. This system uses an image intensifier coupled to a TV camera as a two-dimensional detector so that a set of two-dimensional projections can be acquired for a direct three-dimensional reconstruction (3D). This system has been evaluated with two phantoms: a vascular phantom and a monkey head cadaver. One hundred eighty projections of each phantom were acquired with the system. A set of three-dimensional images were directly reconstructed from the projection data. The experimental results indicate that good imaging quality can be obtained with this system.

Growth kinetics of gamma-prime precipitates in a directionally solidified eutectic, gamma/gamma-prime-delta

NASA Technical Reports Server (NTRS)

Tewari, S. N.

1976-01-01

A directionally solidified eutectic alloy (DSEA), of those viewed as potential candidates for the next generation of aircraft gas turbine blade materials, is studied for the gamma-prime growth kinetics, in the system Ni-Nb-Cr-Al, specifically: Ni-20 w/o Nb-6 w/o Cr-2.5 w/o Al gamma/gamma-prime-delta DSEA. Heat treatment, polishing and etching, and preparation for electron micrography are described, and the size distribution of gamma-prime phase following various anneals is plotted, along with gamma-prime growth kinetics in this specific DSEA, and the cube of gamma-prime particle size vs anneal time. Activation energies and coarsening kinetics are studied.

REBOCOL (Robotic Calorimetry): An automated NDA (Nondestructive assay) calorimetry and gamma isotopic system

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hurd, J.R.; Bonner, C.A.; Ostenak, C.A.

1989-01-01

ROBOCAL, which is presently being developed and tested at Los Alamos National Laboratory, is a full-scale, prototypical robotic system, for remote calorimetric and gamma-ray analysis of special nuclear materials. It integrates a fully automated, multi-drawer, vertical stacker-retriever system for staging unmeasured nuclear materials, and a fully automated gantry robot for computer-based selection and transfer of nuclear materials to calorimetric and gamma-ray measurement stations. Since ROBOCAL is designed for minimal operator intervention, a completely programmed user interface and data-base system are provided to interact with the automated mechanical and assay systems. The assay system is designed to completely integrate calorimetric andmore » gamma-ray data acquisition and to perform state-of-the-art analyses on both homogeneous and heterogeneous distributions of nuclear materials in a wide variety of matrices. 10 refs., 10 figs., 4 tabs.« less

Resonance production in. gamma gamma. collisions

DOE Office of Scientific and Technical Information (OSTI.GOV)

Renard, F.M.

1983-04-01

The processes ..gamma gamma.. ..-->.. hadrons can be depicted as follows. One photon creates a q anti q pair which starts to evolve; the other photon can either (A) make its own q anti q pair and the (q anti q q anti q) system continue to evolve or (B) interact with the quarks of the first pair and lead to a modified (q anti q) system in interaction with C = +1 quantum numbers. A review of the recent theoretical activity concerning resonance production and related problems is given under the following headings: hadronic C = +1 spectroscopy (qmore » anti q, qq anti q anti q, q anti q g, gg, ggg bound states and mixing effects); exclusive ..gamma gamma.. processes (generalities, unitarized Born method, VDM and QCD); total cross section (soft and hard contributions); q/sup 2/ dependence of soft processes (soft/hard separation, 1/sup +- +/ resonances); and polarization effects. (WHK)« less

NRF Based Nondestructive Inspection System for SNM by Using Laser-Compton-Backscattering Gamma-Rays

NASA Astrophysics Data System (ADS)

Ohgaki, H.; Omer, M.; Negm, H.; Daito, I.; Zen, H.; Kii, T.; Masuda, K.; Hori, T.; Hajima, R.; Hayakawa, T.; Shizuma, T.; Kando, M.

2015-10-01

A non-destructive inspection system for special nuclear materials (SNMs) hidden in a sea cargo has been developed. The system consists of a fast screening system using neutron generated by inertial electrostatic confinement (IEC) device and an isotope identification system using nuclear resonance fluorescence (NRF) measurements with laser Compton backscattering (LCS) gamma-rays has been developed. The neutron flux of 108 n/sec has been achieved by the IEC in static mode. We have developed a modified neutron reactor noise analysis method to detect fission neutron in a short time. The LCS gamma-rays has been generated by using a small racetrack microtoron accelerator and an intense sub-nano second laser colliding head-on to the electron beam. The gamma-ray flux has been achieved more than 105 photons/s. The NRF gamma-rays will be measured using LaBr3(Ce) scintillation detector array whose performance has been measured by NRF experiment of U-235 in HIGS facility. The whole inspection system has been designed to satisfy a demand from the sea port.

Assistive lesion-emphasis system: an assistive system for fundus image readers

PubMed Central

Rangrej, Samrudhdhi B.; Sivaswamy, Jayanthi

2017-01-01

Abstract. Computer-assisted diagnostic (CAD) tools are of interest as they enable efficient decision-making in clinics and the screening of diseases. The traditional approach to CAD algorithm design focuses on the automated detection of abnormalities independent of the end-user, who can be an image reader or an expert. We propose a reader-centric system design wherein a reader’s attention is drawn to abnormal regions in a least-obtrusive yet effective manner, using saliency-based emphasis of abnormalities and without altering the appearance of the background tissues. We present an assistive lesion-emphasis system (ALES) based on the above idea, for fundus image-based diabetic retinopathy diagnosis. Lesion-saliency is learnt using a convolutional neural network (CNN), inspired by the saliency model of Itti and Koch. The CNN is used to fine-tune standard low-level filters and learn high-level filters for deriving a lesion-saliency map, which is then used to perform lesion-emphasis via a spatially variant version of gamma correction. The proposed system has been evaluated on public datasets and benchmarked against other saliency models. It was found to outperform other saliency models by 6% to 30% and boost the contrast-to-noise ratio of lesions by more than 30%. Results of a perceptual study also underscore the effectiveness and, hence, the potential of ALES as an assistive tool for readers. PMID:28560245

On the Performance of X-ray Imaging Plates in Gamma Radiography employing Reactor-produced Radioisotopes

NASA Astrophysics Data System (ADS)

Silvani, Maria Ines; de Almeida, Gevaldo L.; Furieri, Rosanne C.; Lopes, Ricardo T.

2011-08-01

Gamma-radiography employing radiographic films is a well established technique for non-destructive assays. The advent of X-ray sensitive Imaging Plates opens up new possibilities to apply this technique thanks to the advantages exhibited by this new device. Indeed, besides a sensitivity about 20 times higher then the conventional photographic film, requiring thus a shorter exposure time, it does not require a dark room for a cumbersome and time-consuming chemical processing associated to the development, an can be erased to be reused many times. Moreover, its development carried out by means of a laser beam produces digitalized images which can be promptly stored in a computer. Although its resolution is still poorer than that of the conventional film, those advantages overwhelms this specific parameter when it is not an essential feature for the intended application. This work evaluates the feasibility of employing X-ray Imaging Plates as detector for higher photon energies as those emitted by reactor-produced radioisotopes. Within this frame, radioisotopes such as 198Au and 56Mn, produced at the Argonauta research reactor in the Instituto de Engenharia Nuclear-CNEN have been employed as sources to acquire radiographic images of several pieces of equipment, devices and components. In order to keep the source appearance—with regard to the detector—as punctual as possible, reducing hence the penumbra effect, the mass of the irradiated material had to be limited. Therefore, due to the low neutron flux available at the main port of the reactor, the exposure times have to be extended along several hours or even a couple of days in order to reach an image with adequate contrast. This demand, nevertheless, does not constitute a serious hindrance as the exposure process can be carried out without any intervention or surveillance. Results have shown that in spite of the higher photon energies used, surpassing the X-ray range for which the imaging plates have been

GammaLib and ctools. A software framework for the analysis of astronomical gamma-ray data

NASA Astrophysics Data System (ADS)

Knödlseder, J.; Mayer, M.; Deil, C.; Cayrou, J.-B.; Owen, E.; Kelley-Hoskins, N.; Lu, C.-C.; Buehler, R.; Forest, F.; Louge, T.; Siejkowski, H.; Kosack, K.; Gerard, L.; Schulz, A.; Martin, P.; Sanchez, D.; Ohm, S.; Hassan, T.; Brau-Nogué, S.

2016-08-01

The field of gamma-ray astronomy has seen important progress during the last decade, yet to date no common software framework has been developed for the scientific analysis of gamma-ray telescope data. We propose to fill this gap by means of the GammaLib software, a generic library that we have developed to support the analysis of gamma-ray event data. GammaLib was written in C++ and all functionality is available in Python through an extension module. Based on this framework we have developed the ctools software package, a suite of software tools that enables flexible workflows to be built for the analysis of Imaging Air Cherenkov Telescope event data. The ctools are inspired by science analysis software available for existing high-energy astronomy instruments, and they follow the modular ftools model developed by the High Energy Astrophysics Science Archive Research Center. The ctools were written in Python and C++, and can be either used from the command line via shell scripts or directly from Python. In this paper we present the GammaLib and ctools software versions 1.0 that were released at the end of 2015. GammaLib and ctools are ready for the science analysis of Imaging Air Cherenkov Telescope event data, and also support the analysis of Fermi-LAT data and the exploitation of the COMPTEL legacy data archive. We propose using ctools as the science tools software for the Cherenkov Telescope Array Observatory.

The GAMCIT gamma ray burst detector

NASA Technical Reports Server (NTRS)

Mccall, Benjamin J.; Grunsfeld, John M.; Sobajic, Srdjan D.; Chang, Chinley Leonard; Krum, David M.; Ratner, Albert; Trittschuh, Jennifer E.

1993-01-01

The GAMCIT payload is a Get-Away-Special payload designed to search for high-energy gamma-ray bursts and any associated optical transients. This paper presents details on the design of the GAMCIT payload, in the areas of battery selection, power processing, electronics design, gamma-ray detection systems, and the optical imaging of the transients. The paper discusses the progress of the construction, testing, and specific design details of the payload. In addition, this paper discusses the unique challenges involved in bringing this payload to completion, as the project has been designed, constructed, and managed entirely by undergraduate students. Our experience will certainly be valuable to other student groups interested in taking on a challenging project such as a Get-Away-Special payload.

Data analysis of the COMPTEL instrument on the NASA gamma ray observatory

NASA Technical Reports Server (NTRS)

Diehl, R.; Bennett, K.; Collmar, W.; Connors, A.; Denherder, J. W.; Hermsen, W.; Lichti, G. G.; Lockwood, J. A.; Macri, J.; Mcconnell, M.

1992-01-01

The Compton imaging telescope (COMPTEL) on the Gamma Ray Observatory (GRO) is a wide field of view instrument. The coincidence measurement technique in two scintillation detector layers requires specific analysis methods. Straightforward event projection into the sky is impossible. Therefore, detector events are analyzed in a multi-dimensional dataspace using a gamma ray sky hypothesis convolved with the point spread function of the instrument in this dataspace. Background suppression and analysis techniques have important implications on the gamma ray source results for this background limited telescope. The COMPTEL collaboration applies a software system of analysis utilities, organized around a database management system. The use of this system for the assistance of guest investigators at the various collaboration sites and external sites is foreseen and allows different detail levels of cooperation with the COMPTEL institutes, dependent on the type of data to be studied.

Current trends in gamma radiation detection for radiological emergency response

NASA Astrophysics Data System (ADS)

Mukhopadhyay, Sanjoy; Guss, Paul; Maurer, Richard

2011-09-01

Passive and active detection of gamma rays from shielded radioactive materials, including special nuclear materials, is an important task for any radiological emergency response organization. This article reports on the current trends and status of gamma radiation detection objectives and measurement techniques as applied to nonproliferation and radiological emergencies. In recent years, since the establishment of the Domestic Nuclear Detection Office by the Department of Homeland Security, a tremendous amount of progress has been made in detection materials (scintillators, semiconductors), imaging techniques (Compton imaging, use of active masking and hybrid imaging), data acquisition systems with digital signal processing, field programmable gate arrays and embedded isotopic analysis software (viz. gamma detector response and analysis software [GADRAS]1), fast template matching, and data fusion (merging radiological data with geo-referenced maps, digital imagery to provide better situational awareness). In this stride to progress, a significant amount of inter-disciplinary research and development has taken place-techniques and spin-offs from medical science (such as x-ray radiography and tomography), materials engineering (systematic planned studies on scintillators to optimize several qualities of a good scintillator, nanoparticle applications, quantum dots, and photonic crystals, just to name a few). No trend analysis of radiation detection systems would be complete without mentioning the unprecedented strategic position taken by the National Nuclear Security Administration (NNSA) to deter, detect, and interdict illicit trafficking in nuclear and other radioactive materials across international borders and through the global maritime transportation-the so-called second line of defense.

Development of Neutron Imaging System for Neutron Tomography at Thai Research Reactor TRR-1/M1

NASA Astrophysics Data System (ADS)

Wonglee, S.; Khaweerat, S.; Channuie, J.; Picha, R.; Liamsuwan, T.; Ratanatongchai, W.

2017-09-01

The neutron imaging is a powerful non-destructive technique to investigate the internal structure and provides the information which is different from the conventional X-ray/Gamma radiography. By reconstruction of the obtained 2-dimentional (2D) images from the taken different angle around the specimen, the tomographic image can be obtained and it can provide the information in more detail. The neutron imaging system at Thai Research Reactor TRR-1/M1 of Thailand Institute of Nuclear Technology (Public Organization) has been developed to conduct the neutron tomography since 2014. The primary goal of this work is to serve the investigation of archeological samples, however, this technique can also be applied to various fields, such as investigation of industrial specimen and others. This research paper presents the performance study of a compact neutron camera manufactured by Neutron Optics such as speed and sensitivity. Furthermore, the 3-dimentional (3D) neutron image was successfully reconstructed at the developed neutron imaging system of TRR-1/M1.

Plasma interferon-gamma and interleukin-10 concentrations in systemic meningococcal disease compared with severe systemic Gram-positive septic shock.

PubMed

Bjerre, Anna; Brusletto, Berit; Høiby, Ernst Arne; Kierulf, Peter; Brandtzaeg, Petter

2004-02-01

To analyze plasma interferon-gamma and interleukin-10 concentrations in patients with systemic meningococcal disease and patients with severe Gram-positive septic shock caused by Streptococcus pneumoniae or Staphylococcus aureus. To study the in vitro cytokine (interferon-gamma and interleukin-10) responses in a whole blood model boosted with heat-killed Neisseria meningitidis, S. pneumoniae, and S. aureus before and after treatment with recombinant interleukin-10 or recombinant interferon-gamma. Experimental study. Laboratory. Plasma samples were collected from patients with systemic meningococcal disease (n = 66) and patients with severe Gram-positive septic shock caused by S. pneumoniae (n = 4) or S. aureus (n = 3). Whole blood was boosted with heat-killed N. meningitidis, S. pneumoniae, and S. aureus (1 x 106 colony forming units/mL), and plasmas were analyzed for interleukin-10 or interferon-gamma at 0, 5, 12, and 24 hrs. Furthermore, recombinant interleukin-10 or recombinant interferon-gamma was added before bacteria, and the effect on the secretion of interferon-gamma and interleukin-10, respectively, was analyzed after 24 hrs. The median concentration of interferon-gamma was 15 pg/mL and of interleukin-10 was 10,269 pg/mL in patients with meningococcal septic shock (n = 24) compared with median interferon-gamma concentration of 3400 pg/mL and interleukin-10 concentration of 465 pg/mL in patients with severe Gram-positive shock (p =.001). Increased interferon-gamma concentrations were associated with case fatality (p =.011). In a whole blood model we demonstrated that 1 x 106 colony forming units/mL of N. meningitidis induced more interleukin-10 but less interferon-gamma than S. pneumoniae. S. aureus induced minimal secretion of both cytokines. Recombinant interleukin-10 efficiently down-regulated the secretion of interferon-gamma, and vice versa, as shown in a whole blood model. We speculate whether high concentrations of interleukin-10 contribute to the

Simulations of Multi-Gamma Coincidences From Neutron-Induced Fission in Special Nuclear Materials

NASA Astrophysics Data System (ADS)

Kane, Steven; Gozani, Tsahi; King, Michael J.; Kwong, John; Brown, Craig; Gary, Charles; Firestone, Murray I.; Nikkel, James A.; McKinsey, Daniel N.

2013-04-01

A study is presented on the detection of illicit special nuclear materials (SNM) in cargo containers using a conceptual neutron-based inspection system with xenon-doped liquefied argon (LAr(Xe)) scintillation detectors for coincidence gamma-ray detection. For robustness, the system is envisioned to exploit all fission signatures, namely both prompt and delayed neutron and gamma emissions from fission reactions induced in SNM. However, this paper focuses exclusively on the analysis of the prompt gamma ray emissions. The inspection system probes a container using neutrons produced either by (d, D) or (d, T) in pulsed form or from an associated particle neutron generator to exploit the associated particle imaging (API) technique, thereby achieving background reduction and imaging. Simulated signal and background estimates were obtained in MCNPX (2.7) for a 2 kg sphere of enriched uranium positioned at the center of a 1m × 1m × 1m container, which is filled uniformly with wood or iron cargos at 0.1 g/cc or 0.4 g/cc. Detection time estimates are reported assuming probabilities of detection of 95% and false alarm of 0.5%.

A fully automatic approach for multimodal PET and MR image segmentation in gamma knife treatment planning.

PubMed

Rundo, Leonardo; Stefano, Alessandro; Militello, Carmelo; Russo, Giorgio; Sabini, Maria Gabriella; D'Arrigo, Corrado; Marletta, Francesco; Ippolito, Massimo; Mauri, Giancarlo; Vitabile, Salvatore; Gilardi, Maria Carla

2017-06-01

Nowadays, clinical practice in Gamma Knife treatments is generally based on MRI anatomical information alone. However, the joint use of MRI and PET images can be useful for considering both anatomical and metabolic information about the lesion to be treated. In this paper we present a co-segmentation method to integrate the segmented Biological Target Volume (BTV), using [ 11 C]-Methionine-PET (MET-PET) images, and the segmented Gross Target Volume (GTV), on the respective co-registered MR images. The resulting volume gives enhanced brain tumor information to be used in stereotactic neuro-radiosurgery treatment planning. GTV often does not match entirely with BTV, which provides metabolic information about brain lesions. For this reason, PET imaging is valuable and it could be used to provide complementary information useful for treatment planning. In this way, BTV can be used to modify GTV, enhancing Clinical Target Volume (CTV) delineation. A novel fully automatic multimodal PET/MRI segmentation method for Leksell Gamma Knife ® treatments is proposed. This approach improves and combines two computer-assisted and operator-independent single modality methods, previously developed and validated, to segment BTV and GTV from PET and MR images, respectively. In addition, the GTV is utilized to combine the superior contrast of PET images with the higher spatial resolution of MRI, obtaining a new BTV, called BTV MRI . A total of 19 brain metastatic tumors, undergone stereotactic neuro-radiosurgery, were retrospectively analyzed. A framework for the evaluation of multimodal PET/MRI segmentation is also presented. Overlap-based and spatial distance-based metrics were considered to quantify similarity concerning PET and MRI segmentation approaches. Statistics was also included to measure correlation among the different segmentation processes. Since it is not possible to define a gold-standard CTV according to both MRI and PET images without treatment response assessment

Gamma-resonance Contraband Detection using a high current tandem accelerator

NASA Astrophysics Data System (ADS)

Milton, B. F.; Beis, J.; Dale, D.; Debiak, T.; Kamykowski, E.; Melnychuk, S.; Rathke, J.; Rogers, J.; Ruegg, R.; Sredniawski, J.

1999-04-01

TRIUMF and Northrop Grumman have developed a new system for the detection of concealed explosives and drugs. This Contraband Detection System (CDS) is based on the resonant absorption by 14N of gammas produced using 13C(p,γ)14N. The chosen reaction uses protons at 1.75 MeV and the gammas have an energy of 9.17 MeV. By measuring both the resonant and the non-resonant absorption using detectors with good spatial resolution, and applying standard tomographic techniques, we are able to produce 3D images of both the nitrogen partial density and the total density. The images together may be utilized with considerable confidence to determine if small amounts of nitrogen based explosives, heroin or cocaine are present in the interrogated containers. Practical Gamma Resonant Absorption (GRA) scanning requires an intense source of protons. However this proton source must also be very stable, have low energy spread, and have good spatial definition. These demands suggested a tandem as the accelerator of choice. We have therefore constructed a 2 MeV H- tandem optimized for high current (10 mA) operation, while minimizing the overall size of the accelerator. This has required several special innovations which will be presented in the paper. We will also present initial commissioning results.

Low-background gamma-ray spectrometry for the international monitoring system

DOE PAGES

Greenwood, L. R.; Cantaloub, M. G.; Burnett, J. L.; ...

2016-12-28

PNNL has developed two low-background gamma-ray spectrometers in a new shallow underground laboratory, thereby significantly improving its ability to detect low levels of gamma-ray emitting fission or activation products in airborne particulate in samples from the IMS (International Monitoring System). Furthermore, the combination of cosmic veto panels, dry nitrogen gas to reduce radon and low background shielding results in a reduction of the background count rate by about a factor of 100 compared to detectors operating above ground at our laboratory.

Fermi-LAT Detection of Gravitational Lens Delayed Gamma-Ray Flares from Blazar B0218+357

NASA Technical Reports Server (NTRS)

Cheung, C. C.; Larsson, S.; Scargle, J. D.; Amin, M. A.; Blandford, R. D.; Bulmash, D.; Chiang, J.; Ciprini, S.; Corbet, R. D. H.; Falco, E. E.;

Medical imaging systems

DOEpatents

Frangioni, John V [Wayland, MA

2012-07-24

A medical imaging system provides simultaneous rendering of visible light and fluorescent images. The system may employ dyes in a small-molecule form that remains in a subject's blood stream for several minutes, allowing real-time imaging of the subject's circulatory system superimposed upon a conventional, visible light image of the subject. The system may also employ dyes or other fluorescent substances associated with antibodies, antibody fragments, or ligands that accumulate within a region of diagnostic significance. In one embodiment, the system provides an excitation light source to excite the fluorescent substance and a visible light source for general illumination within the same optical guide that is used to capture images. In another embodiment, the system is configured for use in open surgical procedures by providing an operating area that is closed to ambient light. More broadly, the systems described herein may be used in imaging applications where a visible light image may be usefully supplemented by an image formed from fluorescent emissions from a fluorescent substance that marks areas of functional interest.

Investigation of runaway electron dissipation in DIII-D using a gamma ray imager

NASA Astrophysics Data System (ADS)

Lvovskiy, A.; Paz-Soldan, C.; Eidietis, N.; Pace, D.; Taussig, D.

2017-10-01

We report the findings of a novel gamma ray imager (GRI) to study runaway electron (RE) dissipation in the quiescent regime on the DIII-D tokamak. The GRI measures the bremsstrahlung emission by RE providing information on RE energy spectrum and distribution across a poloidal cross-section. It consists of a lead pinhole camera illuminating a matrix of BGO detectors placed in the DIII-D mid-plane. The number of detectors was recently doubled to provide better spatial resolution and additional detector shielding was implemented to reduce un-collimated gamma flux and increase single-to-noise ratio. Under varying loop voltage, toroidal magnetic field and plasma density, a non-monotonic RE distribution function has been revealed as a result of the interplay between electric field, synchrotron radiation and collisional damping. A fraction of the high-energy RE population grows forming a bump at the RE distribution function while synchrotron radiation decreases. A possible destabilizing effect of Parail-Pogutse instability on the RE population will be also discussed. Work supported by the US DOE under DE-FC02-04ER54698.

Failure modes and effects analysis (FMEA) for Gamma Knife radiosurgery.

PubMed

Xu, Andy Yuanguang; Bhatnagar, Jagdish; Bednarz, Greg; Flickinger, John; Arai, Yoshio; Vacsulka, Jonet; Feng, Wenzheng; Monaco, Edward; Niranjan, Ajay; Lunsford, L Dade; Huq, M Saiful

2017-11-01

Gamma Knife radiosurgery is a highly precise and accurate treatment technique for treating brain diseases with low risk of serious error that nevertheless could potentially be reduced. We applied the AAPM Task Group 100 recommended failure modes and effects analysis (FMEA) tool to develop a risk-based quality management program for Gamma Knife radiosurgery. A team consisting of medical physicists, radiation oncologists, neurosurgeons, radiation safety officers, nurses, operating room technologists, and schedulers at our institution and an external physicist expert on Gamma Knife was formed for the FMEA study. A process tree and a failure mode table were created for the Gamma Knife radiosurgery procedures using the Leksell Gamma Knife Perfexion and 4C units. Three scores for the probability of occurrence (O), the severity (S), and the probability of no detection for failure mode (D) were assigned to each failure mode by 8 professionals on a scale from 1 to 10. An overall risk priority number (RPN) for each failure mode was then calculated from the averaged O, S, and D scores. The coefficient of variation for each O, S, or D score was also calculated. The failure modes identified were prioritized in terms of both the RPN scores and the severity scores. The established process tree for Gamma Knife radiosurgery consists of 10 subprocesses and 53 steps, including a subprocess for frame placement and 11 steps that are directly related to the frame-based nature of the Gamma Knife radiosurgery. Out of the 86 failure modes identified, 40 Gamma Knife specific failure modes were caused by the potential for inappropriate use of the radiosurgery head frame, the imaging fiducial boxes, the Gamma Knife helmets and plugs, the skull definition tools as well as other features of the GammaPlan treatment planning system. The other 46 failure modes are associated with the registration, imaging, image transfer, contouring processes that are common for all external beam radiation therapy

SER Analysis of MPPM-Coded MIMO-FSO System over Uncorrelated and Correlated Gamma-Gamma Atmospheric Turbulence Channels

NASA Astrophysics Data System (ADS)

Khallaf, Haitham S.; Garrido-Balsells, José M.; Shalaby, Hossam M. H.; Sampei, Seiichi

2015-12-01

The performance of multiple-input multiple-output free space optical (MIMO-FSO) communication systems, that adopt multipulse pulse position modulation (MPPM) techniques, is analyzed. Both exact and approximate symbol-error rates (SERs) are derived for both cases of uncorrelated and correlated channels. The effects of background noise, receiver shot-noise, and atmospheric turbulence are taken into consideration in our analysis. The random fluctuations of the received optical irradiance, produced by the atmospheric turbulence, is modeled by the widely used gamma-gamma statistical distribution. Uncorrelated MIMO channels are modeled by the α-μ distribution. A closed-form expression for the probability density function of the optical received irradiance is derived for the case of correlated MIMO channels. Using our analytical expressions, the degradation of the system performance with the increment of the correlation coefficients between MIMO channels is corroborated.

AMPX: a modular code system for generating coupled multigroup neutron-gamma libraries from ENDF/B

DOE Office of Scientific and Technical Information (OSTI.GOV)

Greene, N.M.; Lucius, J.L.; Petrie, L.M.

1976-03-01

AMPX is a modular system for producing coupled multigroup neutron-gamma cross section sets. Basic neutron and gamma cross-section data for AMPX are obtained from ENDF/B libraries. Most commonly used operations required to generate and collapse multigroup cross-section sets are provided in the system. AMPX is flexibly dimensioned; neutron group structures, and gamma group structures, and expansion orders to represent anisotropic processes are all arbitrary and limited only by available computer core and budget. The basic processes provided will (1) generate multigroup neutron cross sections; (2) generate multigroup gamma cross sections; (3) generate gamma yields for gamma-producing neutron interactions; (4) combinemore » neutron cross sections, gamma cross sections, and gamma yields into final ''coupled sets''; (5) perform one-dimensional discrete ordinates transport or diffusion theory calculations for neutrons and gammas and, on option, collapse the cross sections to a broad-group structure, using the one-dimensional results as weighting functions; (6) plot cross sections, on option, to facilitate the ''evaluation'' of a particular multigroup set of data; (7) update and maintain multigroup cross section libraries in such a manner as to make it not only easy to combine new data with previously processed data but also to do it in a single pass on the computer; and (8) output multigroup cross sections in convenient formats for other codes. (auth)« less

Localized cerebral energy failure in DNA polymerase gamma-associated encephalopathy syndromes.

PubMed

Tzoulis, Charalampos; Neckelmann, Gesche; Mørk, Sverre J; Engelsen, Bernt E; Viscomi, Carlo; Moen, Gunnar; Ersland, Lars; Zeviani, Massimo; Bindoff, Laurence A

2010-05-01

Mutations in the catalytic subunit of the mitochondrial DNA-polymerase gamma cause a wide spectrum of clinical disease ranging from infantile hepato-encephalopathy to juvenile/adult-onset spinocerebellar ataxia and late onset progressive external ophthalmoplegia. Several of these syndromes are associated with an encephalopathy that characteristically shows episodes of rapid neurological deterioration and the development of acute cerebral lesions. The purpose of this study was to investigate the nature, distribution and natural evolution of central nervous system lesions in polymerase gamma associated encephalopathy focusing particularly on lesions identified by magnetic resonance imaging. We compared radiological, electrophysiological and pathological findings where available to study potential mechanisms underlying the episodes of exacerbation and acute cerebral lesions. We studied a total of 112 magnetic resonance tomographies and 11 computed tomographies in 32 patients with polymerase gamma-encephalopathy, including multiple serial examinations performed during both the chronic and acute phases of the disease and, in several cases, magnetic resonance spectroscopy and serial diffusion weighted studies. Data from imaging, electroencephalography and post-mortem examination were compared in order to study the underlying disease process. Our findings show that magnetic resonance imaging in polymerase gamma-related encephalopathies has high sensitivity and can identify patterns that are specific for individual syndromes. One form of chronic polymerase gamma-encephalopathy, that is associated with the c.1399G > A and c.2243G > C mutations, is characterized by progressive cerebral and cerebellar atrophy and focal lesions of the thalamus, deep cerebellar structures and medulla oblongata. Acute encephalopathies, both infantile and later onset, show similar pictures with cortical stroke-like lesions occurring during episodes of exacerbation. These lesions can occur both

Gamma Ray Burst Optical Counterpart Search Experiment (GROCSE)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Park, H.S.; Ables, E.; Bionta, R.M.

GROCSE (Gamma-Ray Optical Counterpart Search Experiments) is a system of automated telescopes that search for simultaneous optical activity associated with gamma ray bursts in response to real-time burst notifications provided by the BATSE/BACODINE network. The first generation system, GROCSE 1, is sensitive down to Mv {approximately} 8.5 and requires an average of 12 seconds to obtain the first images of the gamma ray burst error box defined by the BACODINE trigger. The collaboration is now constructing a second generation system which has a 4 second slewing time and can reach Mv {approximately} 14 with a 5 second exposure. GROCSE 2more » consists of 4 cameras on a single mount. Each camera views the night sky through a commercial Canon lens (f/1.8, focal length 200 mm) and utilizes a 2K x 2K Loral CCD. Light weight and low noise custom readout electronics were designed and fabricated for these CCDs. The total field of view of the 4 cameras is 17.6 x 17.6 {degree}. GROCSE II will be operated by the end of 1995. In this paper, the authors present an overview of the GROCSE system and the results of measurements with a GROCSE 2 prototype unit.« less

Electron Trajectory Reconstruction for Advanced Compton Imaging of Gamma Rays

NASA Astrophysics Data System (ADS)

Plimley, Brian Christopher

Gamma-ray imaging is useful for detecting, characterizing, and localizing sources in a variety of fields, including nuclear physics, security, nuclear accident response, nuclear medicine, and astronomy. Compton imaging in particular provides sensitivity to weak sources and good angular resolution in a large field of view. However, the photon origin in a single event sequence is normally only limited to the surface of a cone. If the initial direction of the Compton-scattered electron can be measured, the cone can be reduced to a cone segment with width depending on the uncertainty in the direction measurement, providing a corresponding increase in imaging sensitivity. Measurement of the electron's initial direction in an efficient detection material requires very fine position resolution due to the electron's short range and tortuous path. A thick (650 mum), fully-depleted charge-coupled device (CCD) developed for infrared astronomy has 10.5-mum position resolution in two dimensions, enabling the initial trajectory measurement of electrons of energy as low as 100 keV. This is the first time the initial trajectories of electrons of such low energies have been measured in a solid material. In this work, the CCD's efficacy as a gamma-ray detector is demonstrated experimentally, using a reconstruction algorithm to measure the initial electron direction from the CCD track image. In addition, models of fast electron interaction physics, charge transport and readout were used to generate modeled tracks with known initial direction. These modeled tracks allowed the development and refinement of the reconstruction algorithm. The angular sensitivity of the reconstruction algorithm is evaluated extensively with models for tracks below 480 keV, showing a FWHM as low as 20° in the pixel plane, and 30° RMS sensitivity to the magnitude of the out-of-plane angle. The measurement of the trajectories of electrons with energies as low as 100 keV have the potential to make electron

High-Speed Data Acquisition and Digital Signal Processing System for PET Imaging Techniques Applied to Mammography

NASA Astrophysics Data System (ADS)

Martinez, J. D.; Benlloch, J. M.; Cerda, J.; Lerche, Ch. W.; Pavon, N.; Sebastia, A.

2004-06-01

This paper is framed into the Positron Emission Mammography (PEM) project, whose aim is to develop an innovative gamma ray sensor for early breast cancer diagnosis. Currently, breast cancer is detected using low-energy X-ray screening. However, functional imaging techniques such as PET/FDG could be employed to detect breast cancer and track disease changes with greater sensitivity. Furthermore, a small and less expensive PET camera can be utilized minimizing main problems of whole body PET. To accomplish these objectives, we are developing a new gamma ray sensor based on a newly released photodetector. However, a dedicated PEM detector requires an adequate data acquisition (DAQ) and processing system. The characterization of gamma events needs a free-running analog-to-digital converter (ADC) with sampling rates of more than 50 Ms/s and must achieve event count rates up to 10 MHz. Moreover, comprehensive data processing must be carried out to obtain event parameters necessary for performing the image reconstruction. A new generation digital signal processor (DSP) has been used to comply with these requirements. This device enables us to manage the DAQ system at up to 80 Ms/s and to execute intensive calculi over the detector signals. This paper describes our designed DAQ and processing architecture whose main features are: very high-speed data conversion, multichannel synchronized acquisition with zero dead time, a digital triggering scheme, and high throughput of data with an extensive optimization of the signal processing algorithms.

Neutron monitoring systems including gamma thermometers and methods of calibrating nuclear instruments using gamma thermometers

DOEpatents

Moen, Stephan Craig; Meyers, Craig Glenn; Petzen, John Alexander; Foard, Adam Muhling

2012-08-07

A method of calibrating a nuclear instrument using a gamma thermometer may include: measuring, in the instrument, local neutron flux; generating, from the instrument, a first signal proportional to the neutron flux; measuring, in the gamma thermometer, local gamma flux; generating, from the gamma thermometer, a second signal proportional to the gamma flux; compensating the second signal; and calibrating a gain of the instrument based on the compensated second signal. Compensating the second signal may include: calculating selected yield fractions for specific groups of delayed gamma sources; calculating time constants for the specific groups; calculating a third signal that corresponds to delayed local gamma flux based on the selected yield fractions and time constants; and calculating the compensated second signal by subtracting the third signal from the second signal. The specific groups may have decay time constants greater than 5.times.10.sup.-1 seconds and less than 5.times.10.sup.5 seconds.

NVIDIA OptiX ray-tracing engine as a new tool for modelling medical imaging systems

NASA Astrophysics Data System (ADS)

Pietrzak, Jakub; Kacperski, Krzysztof; Cieślar, Marek

2015-03-01

The most accurate technique to model the X- and gamma radiation path through a numerically defined object is the Monte Carlo simulation which follows single photons according to their interaction probabilities. A simplified and much faster approach, which just integrates total interaction probabilities along selected paths, is known as ray tracing. Both techniques are used in medical imaging for simulating real imaging systems and as projectors required in iterative tomographic reconstruction algorithms. These approaches are ready for massive parallel implementation e.g. on Graphics Processing Units (GPU), which can greatly accelerate the computation time at a relatively low cost. In this paper we describe the application of the NVIDIA OptiX ray-tracing engine, popular in professional graphics and rendering applications, as a new powerful tool for X- and gamma ray-tracing in medical imaging. It allows the implementation of a variety of physical interactions of rays with pixel-, mesh- or nurbs-based objects, and recording any required quantities, like path integrals, interaction sites, deposited energies, and others. Using the OptiX engine we have implemented a code for rapid Monte Carlo simulations of Single Photon Emission Computed Tomography (SPECT) imaging, as well as the ray-tracing projector, which can be used in reconstruction algorithms. The engine generates efficient, scalable and optimized GPU code, ready to run on multi GPU heterogeneous systems. We have compared the results our simulations with the GATE package. With the OptiX engine the computation time of a Monte Carlo simulation can be reduced from days to minutes.

SU-G-BRB-16: Vulnerabilities in the Gamma Metric

DOE Office of Scientific and Technical Information (OSTI.GOV)

Neal, B; Siebers, J

Purpose: To explore vulnerabilities in the gamma index metric that undermine its wide use as a radiation therapy quality assurance tool. Methods: 2D test field pairs (images) are created specifically to achieve high gamma passing rates, but to also include gross errors by exploiting the distance-to-agreement and percent-passing components of the metric. The first set has no requirement of clinical practicality, but is intended to expose vulnerabilities. The second set exposes clinically realistic vulnerabilities. To circumvent limitations inherent to user-specific tuning of prediction algorithms to match measurements, digital test cases are manually constructed, thereby mimicking high-quality image prediction. Results: Withmore » a 3 mm distance-to-agreement metric, changing field size by ±6 mm results in a gamma passing rate over 99%. For a uniform field, a lattice of passing points spaced 5 mm apart results in a passing rate of 100%. Exploiting the percent-passing component, a 10×10 cm{sup 2} field can have a 95% passing rate when an 8 cm{sup 2}=2.8×2.8 cm{sup 2} highly out-of-tolerance (e.g. zero dose) square is missing from the comparison image. For clinically realistic vulnerabilities, an arc plan for which a 2D image is created can have a >95% passing rate solely due to agreement in the lateral spillage, with the failing 5% in the critical target region. A field with an integrated boost (e.g whole brain plus small metastases) could neglect the metastases entirely, yet still pass with a 95% threshold. All the failure modes described would be visually apparent on a gamma-map image. Conclusion: The %gamma<1 metric has significant vulnerabilities. High passing rates can obscure critical faults in hypothetical and delivered radiation doses. Great caution should be used with gamma as a QA metric; users should inspect the gamma-map. Visual analysis of gamma-maps may be impractical for cine acquisition.« less

Motion correction for passive radiation imaging of small vessels in ship-to-ship inspections

NASA Astrophysics Data System (ADS)

Ziock, K. P.; Boehnen, C. B.; Ernst, J. M.; Fabris, L.; Hayward, J. P.; Karnowski, T. P.; Paquit, V. C.; Patlolla, D. R.; Trombino, D. G.

2016-01-01

Passive radiation detection remains one of the most acceptable means of ascertaining the presence of illicit nuclear materials. In maritime applications it is most effective against small to moderately sized vessels, where attenuation in the target vessel is of less concern. Unfortunately, imaging methods that can remove source confusion, localize a source, and avoid other systematic detection issues cannot be easily applied in ship-to-ship inspections because relative motion of the vessels blurs the results over many pixels, significantly reducing system sensitivity. This is particularly true for the smaller watercraft, where passive inspections are most valuable. We have developed a combined gamma-ray, stereo visible-light imaging system that addresses this problem. Data from the stereo imager are used to track the relative location and orientation of the target vessel in the field of view of a coded-aperture gamma-ray imager. Using this information, short-exposure gamma-ray images are projected onto the target vessel using simple tomographic back-projection techniques, revealing the location of any sources within the target. The complex autonomous tracking and image reconstruction system runs in real time on a 48-core workstation that deploys with the system.

Recommended Priorities for NASA's Gamma Ray Astronomy Program 1999-2013

NASA Technical Reports Server (NTRS)

Carol, Ladd

1999-01-01

The Gamma-Ray Astronomy Program Working Group (GRAPWG) recommends priorities for the NASA Gamma-Ray Astronomy Program. The highest priority science topic is nuclear astrophysics and sites of gamma ray line emission. Other high priority topics are gamma ray bursts, hard x-ray emission from accreting black holes and neutron stars, the Advanced Compton Telescope (ACT), the High-resolution Spectroscopic Imager (HSI), and the Energetic X-ray Imaging Survey Telescope (EXIST). The recommendations include special consideration for technology development, TeV astronomy, the ultra-long duration balloon (ULDB) program, the International Space Station, optical telescope support, and data analysis and theory.

Spectrographic imaging system

DOEpatents

Morris, Michael D.; Treado, Patrick J.

1991-01-01

An imaging system for providing spectrographically resolved images. The system incorporates a one-dimensional spatial encoding mask which enables an image to be projected onto a two-dimensional image detector after spectral dispersion of the image. The dimension of the image which is lost due to spectral dispersion on the two-dimensional detector is recovered through employing a reverse transform based on presenting a multiplicity of different spatial encoding patterns to the image. The system is especially adapted for detecting Raman scattering of monochromatic light transmitted through or reflected from physical samples. Preferably, spatial encoding is achieved through the use of Hadamard mask which selectively transmits or blocks portions of the image from the sample being evaluated.

EDITORIAL: Imaging Systems and Techniques Imaging Systems and Techniques

NASA Astrophysics Data System (ADS)

Giakos, George; Yang, Wuqiang; Petrou, M.; Nikita, K. S.; Pastorino, M.; Amanatiadis, A.; Zentai, G.

2011-10-01

This special feature on Imaging Systems and Techniques comprises 27 technical papers, covering essential facets in imaging systems and techniques both in theory and applications, from research groups spanning three different continents. It mainly contains peer-reviewed articles from the IEEE International Conference on Imaging Systems and Techniques (IST 2011), held in Thessaloniki, Greece, as well a number of articles relevant to the scope of this issue. The multifaceted field of imaging requires drastic adaptation to the rapid changes in our society, economy, environment, and the technological revolution; there is an urgent need to address and propose dynamic and innovative solutions to problems that tend to be either complex and static or rapidly evolving with a lot of unknowns. For instance, exploration of the engineering and physical principles of new imaging systems and techniques for medical applications, remote sensing, monitoring of space resources and enhanced awareness, exploration and management of natural resources, and environmental monitoring, are some of the areas that need to be addressed with urgency. Similarly, the development of efficient medical imaging techniques capable of providing physiological information at the molecular level is another important area of research. Advanced metabolic and functional imaging techniques, operating on multiple physical principles, using high resolution and high selectivity nanoimaging techniques, can play an important role in the diagnosis and treatment of cancer, as well as provide efficient drug-delivery imaging solutions for disease treatment with increased sensitivity and specificity. On the other hand, technical advances in the development of efficient digital imaging systems and techniques and tomographic devices operating on electric impedance tomography, computed tomography, single-photon emission and positron emission tomography detection principles are anticipated to have a significant impact on a

The AGILE Mission and Gamma-Ray Bursts

DOE Office of Scientific and Technical Information (OSTI.GOV)

Longo, Francesco; INFN, section of Trieste; Tavani, M.

2007-05-01

The AGILE Mission will explore the gamma-ray Universe with a very innovative instrument combining for the first time a gamma-ray imager and a hard X-ray imager. AGILE will be operational at the beginning of 2007 and it will provide crucial data for the study of Active Galactic Nuclei, Gamma-Ray Bursts, unidentified gamma-ray sources, Galactic compact objects, supernova remnants, TeV sources, and fundamental physics by microsecond timing. The AGILE instrument is designed to simultaneously detect and image photons in the 30 MeV - 50 GeV and 15 - 45 keV energy bands with excellent imaging and timing capabilities, and a largemore » field of view covering {approx} 1/5 of the entire sky at energies above 30 MeV. A CsI calorimeter is capable of GRB triggering in the energy band 0.3-50 MeV. The broadband detection of GRBs and the study of implications for particle acceleration and high energy emission are primary goals of the mission. AGILE can image GRBs with 2-3 arcminute error boxes in the hard X-ray range, and provide broadband photon-by photon detection in the 15-45 keV, 03-50 MeV, and 30 MeV-30 GeV energy ranges. Microsecond on-board photon tagging and a {approx} 100 microsecond gamma-ray detection deadtime will be crucial for fast GRB timing. On-board calculated GRB coordinates and energy fluxes will be quickly transmitted to the ground by an ORBCOMM transceiver. AGILE is now (January 2007) undergoing final satellite integration and testing. The PLS V launch is planned in spring 2007. AGILE is then foreseen to be fully operational during the summer of 2007.« less

Research on the system performance evaluation of minimum-shift keying in uplink ground-to-satellite with gamma-gamma distribution

NASA Astrophysics Data System (ADS)

Wang, Yi; Zhang, Ao; Ma, Jing

2017-07-01

Minimum-shift keying (MSK) has the advantages of constant envelope, continuous phase, and high spectral efficiency, and it is applied in radio communication and optical fiber communication. MSK modulation of coherent detection is proposed in the ground-to-satellite laser communication system; in addition, considering the inherent noise of uplink, such as intensity scintillation and beam wander, the communication performance of the MSK modulation system with coherent detection is studied in the uplink ground-to-satellite laser. Based on the gamma-gamma channel model, the closed form of bit error rate (BER) of MSK modulation with coherent detection is derived. In weak, medium, and strong turbulence, the BER performance of the MSK modulation system is simulated and analyzed. To meet the requirements of the ground-to-satellite coherent MSK system to optimize the parameters and configuration of the transmitter and receiver, the influence of the beam divergence angle, the zenith angle, the transmitter beam radius, and the receiver diameter are studied.

21 CFR 862.1360 - Gamma-glutamyl transpeptidase and isoenzymes test system.

Code of Federal Regulations, 2010 CFR

2010-04-01

... HUMAN SERVICES (CONTINUED) MEDICAL DEVICES CLINICAL CHEMISTRY AND CLINICAL TOXICOLOGY DEVICES Clinical Chemistry Test Systems § 862.1360 Gamma-glutamyl transpeptidase and isoenzymes test system. (a... alcoholic cirrhosis and primary and secondary liver tumors. (b) Classification. Class I (general controls...

A mercury arc lamp-based multi-color confocal real time imaging system for cellular structure and function.

PubMed

Saito, Kenta; Kobayashi, Kentaro; Tani, Tomomi; Nagai, Takeharu

2008-01-01

Multi-point scanning confocal microscopy using a Nipkow disk enables the acquisition of fluorescent images with high spatial and temporal resolutions. Like other single-point scanning confocal systems that use Galvano meter mirrors, a commercially available Nipkow spinning disk confocal unit, Yokogawa CSU10, requires lasers as the excitation light source. The choice of fluorescent dyes is strongly restricted, however, because only a limited number of laser lines can be introduced into a single confocal system. To overcome this problem, we developed an illumination system in which light from a mercury arc lamp is scrambled to make homogeneous light by passing it through a multi-mode optical fiber. This illumination system provides incoherent light with continuous wavelengths, enabling the observation of a wide range of fluorophores. Using this optical system, we demonstrate both the high-speed imaging (up to 100 Hz) of intracellular Ca(2+) propagation, and the multi-color imaging of Ca(2+) and PKC-gamma dynamics in living cells.

Development of a Compton camera for prompt-gamma medical imaging

NASA Astrophysics Data System (ADS)

Aldawood, S.; Thirolf, P. G.; Miani, A.; Böhmer, M.; Dedes, G.; Gernhäuser, R.; Lang, C.; Liprandi, S.; Maier, L.; Marinšek, T.; Mayerhofer, M.; Schaart, D. R.; Lozano, I. Valencia; Parodi, K.

2017-11-01

A Compton camera-based detector system for photon detection from nuclear reactions induced by proton (or heavier ion) beams is under development at LMU Munich, targeting the online range verification of the particle beam in hadron therapy via prompt-gamma imaging. The detector is designed to be capable to reconstruct the photon source origin not only from the Compton scattering kinematics of the primary photon, but also to allow for tracking of the secondary Compton-scattered electrons, thus enabling a γ-source reconstruction also from incompletely absorbed photon events. The Compton camera consists of a monolithic LaBr3:Ce scintillation crystal, read out by a multi-anode PMT acting as absorber, preceded by a stacked array of 6 double-sided silicon strip detectors as scatterers. The detector components have been characterized both under offline and online conditions. The LaBr3:Ce crystal exhibits an excellent time and energy resolution. Using intense collimated 137Cs and 60Co sources, the monolithic scintillator was scanned on a fine 2D grid to generate a reference library of light amplitude distributions that allows for reconstructing the photon interaction position using a k-Nearest Neighbour (k-NN) algorithm. Systematic studies were performed to investigate the performance of the reconstruction algorithm, revealing an improvement of the spatial resolution with increasing photon energy to an optimum value of 3.7(1)mm at 1.33 MeV, achieved with the Categorical Average Pattern (CAP) modification of the k-NN algorithm.

Test results of a new detector system for gamma ray isotopic measurements

DOE Office of Scientific and Technical Information (OSTI.GOV)

Malcom, J.E.; Bonner, C.A.; Hurd, J.R.

1993-08-01

A new type of gamma-ray detector system for isotopic measurements has been developed. This new system, a ``Duo detector`` array, consists of two intrinsic germanium detectors, a planar followed by a coaxial mounted on the same axis within a single cryostat assembly. This configuration allows the isotopic analysis system to take advantage of spectral data results that are collected simultaneously from different gamma-ray energy regimes. Princeton Gamma Tech (PGT) produced several prototypes of this Duo detector array which were then tested by Rocky Flats personnel until the design was optimized. An application for this detector design is in automated, roboticizedmore » NDA systems such as those being developed at the Los Alamos TA-55 Plutonium Facility. The Duo detector design reduces the space necessary for the isotopic instrument by a factor of two (only one liquid nitrogen dewar is needed), and also reduces the complexity of the mechanical systems and controlling software. Data will be presented on measurements of nuclear material with a Duo detector for a wide variety of matrices. Results indicate that the maximum count rate can be increased up to 100,000 counts per second yet maintaining excellent resolution and energy rate product.« less

[Regulating human interferon-gamma gene expression in marrow stromal cells in mice by Tet-off system].

PubMed

Qin, Xin-Tian; Lu, Yue; Tan, Yin-Duo; Chen, Xiao-Qin; Gen, Qi-Rong

2008-01-01

We have constructed plasmid "pTre-IFN-gamma" and proved that the Tet-off system could regulate the expression of human interferon-gamma (IFN-gamma) gene in murine marrow stromal cells in vitro. This study was to investigate the regulatory reversibility of Tet-off system and its effect on the expression of human IFN-gamma gene in murine marrow stromal cells in mice. Plasmids pTet-off and pTre-IFN-gamma were co-transfected into murine marrow stromal cells. The expression of IFN-gamma in marrow stromal cells was detected with ELISA. The marrow stromal cells were transfused into BABL/c naked mice after co-transfection. The expression of IFN-gamma mRNA in the spleen was detected by real-time fluorescent quantitative reverse transcription-polymerase chain reaction (RT-PCR). IFN-gamma protein was detected in the culture solution of marrow stromal cells after co-transfection. The secretion peak appeared within the first 72 h. The protein level of IFN-gamma was significantly lower in 300 ng/ml tetracycline hydrochloride-treated marrow stroma cells than in untreated cells [(67.11+/-22.14) pg/1 x 10(7) cells vs. (319.96+/-29.04) pg/1 x 10(7) cells, P<0.001]; its expression was increased when removed tetracycline hydrochloride (P=0.032). The expression of human IFN-gamma mRNA was detected in the spleen. The mRNA level of IFN-gamma was significantly higher in untreated group than in continuous tetracycline hydrochloride-treated group [(1.5+/-0.7)x10(5) copies . (100 mg)(-1) vs. (6.9+/-5.3)x10(2) copies . (100 mg)(-1), P<0.001]; its expression in the mice received tetracycline hydrochloride for one single time lay between the above two groups with significant difference. In mice, Tet-off system could rapidly, efficiently and reversibly regulate the expression of human IFN-gamma gene in marrow stromal cells in vitro and in vivo.

Applying the new gamma ray imager diagnostic to measurements of runaway electron Bremsstrahlung radiation in the DIII-D Tokamak (invited)

NASA Astrophysics Data System (ADS)

Cooper, C. M.; Pace, D. C.; Paz-Soldan, C.; Commaux, N.; Eidietis, N. W.; Hollmann, E. M.; Shiraki, D.

2016-11-01

A new gamma ray imager (GRI) is developed to probe the electron distribution function with 2D spatial resolution during runaway electron (RE) experiments at the DIII-D tokamak. The diagnostic is sensitive to 0.5-100 MeV gamma rays, allowing characterization of the RE distribution function evolution during RE growth and dissipation. The GRI consists of a lead "pinhole camera" mounted on the DIII-D midplane with 123 honeycombed tangential chords 20 cm wide that span the vessel interior. Up to 30 bismuth germanate (BGO) scintillation detectors capture RE bremsstrahlung radiation for Pulse Height Analysis (PHA) capable of discriminating up to 20 000 pulses per second. Digital signal processing routines combining shaping filters are performed during PHA to reject noise and record gamma ray energy. The GRI setup and PHA algorithms will be described and initial data from experiments will be presented. A synthetic diagnostic is developed to generate the gamma ray spectrum of a GRI channel given the plasma information and a prescribed distribution function. Magnetic reconstructions of the plasma are used to calculate the angle between every GRI sightline and orient and discriminate gamma rays emitted by a field-aligned RE distribution function.

Applying the new gamma ray imager diagnostic to measurements of runaway electron Bremsstrahlung radiation in the DIII-D Tokamak (invited).

PubMed

Cooper, C M; Pace, D C; Paz-Soldan, C; Commaux, N; Eidietis, N W; Hollmann, E M; Shiraki, D

2016-11-01

A new gamma ray imager (GRI) is developed to probe the electron distribution function with 2D spatial resolution during runaway electron (RE) experiments at the DIII-D tokamak. The diagnostic is sensitive to 0.5-100 MeV gamma rays, allowing characterization of the RE distribution function evolution during RE growth and dissipation. The GRI consists of a lead "pinhole camera" mounted on the DIII-D midplane with 123 honeycombed tangential chords 20 cm wide that span the vessel interior. Up to 30 bismuth germanate (BGO) scintillation detectors capture RE bremsstrahlung radiation for Pulse Height Analysis (PHA) capable of discriminating up to 20 000 pulses per second. Digital signal processing routines combining shaping filters are performed during PHA to reject noise and record gamma ray energy. The GRI setup and PHA algorithms will be described and initial data from experiments will be presented. A synthetic diagnostic is developed to generate the gamma ray spectrum of a GRI channel given the plasma information and a prescribed distribution function. Magnetic reconstructions of the plasma are used to calculate the angle between every GRI sightline and orient and discriminate gamma rays emitted by a field-aligned RE distribution function.

Gamma signatures of the C-BORD Tagged Neutron Inspection System

NASA Astrophysics Data System (ADS)

Sardet, A.; Pérot, B.; Carasco, C.; Sannié, G.; Moretto, S.; Nebbia, G.; Fontana, C.; Pino, F.; Iovene, A.; Tintori, C.

2018-01-01

In the frame of C-BORD project (H2020 program of the EU), a Rapidly relocatable Tagged Neutron Inspection System (RRTNIS) is being developed to non-intrusively detect explosives, chemical threats, and other illicit goods in cargo containers. Material identification is performed through gamma spectroscopy, using twenty NaI detectors and four LaBr3 detectors, to determine the different elements composing the inspected item from their specific gamma signatures induced by fast neutrons. This is performed using an unfolding algorithm to decompose the energy spectrum of a suspect item, selected by X-ray radiography and on which the RRTNIS inspection is focused, on a database of pure element gamma signatures. This paper reports on simulated signatures for the NaI and LaBr3 detectors, constructed using the MCNP6 code. First experimental spectra of a few elements of interest are also presented.

Predicted TeV Gamma-ray Spectra and Images of Shell Supernova Remnants

NASA Astrophysics Data System (ADS)

Reynolds, S. P.

1999-04-01

One supernova remnant, SN 1006, is now known to produce synchrotron X-rays (Koyama et al., 1995, Nature, 378, 255), requiring 100 TeV electrons. SN 1006 has also been seen in TeV gamma rays (Tanimori et al., 1998, ApJ, 497, L25), almost certainly due to cosmic-microwave-background photons being upscattered by those same electrons. Other young supernova remnants should also produce high-energy electrons, even if their X-ray synchrotron emission is swamped by conventional thermal X-ray emission. Upper limits to the maximum energy of shock-accelerated electrons can be found for those remnants by requiring that their synchrotron spectrum steepen enough to fall below observed thermal X-rays (Reynolds and Keohane 1999, ApJ, submitted). For those upper-limit spectra, I present predicted TeV inverse-Compton spectra and images for assumed values of the mean remnant magnetic field. Ground-based TeV gamma-ray observations of remnants may be able to put even more severe limits on the presence of highly energetic electrons in remnants, raising problems for conventional theories of galactic cosmic-ray production in supernova remnants. Detections will immediately confirm that SN 1006 is not alone, and will give mean remnant magnetic field strengths.

Addressing the third gamma problem in PET

NASA Astrophysics Data System (ADS)

Schueller, M. J.; Mulnix, T. L.; Christian, B. T.; Jensen, M.; Holm, S.; Oakes, T. R.; Roberts, A. D.; Dick, D. W.; Martin, C. C.; Nickles, R. J.

2003-02-01

PET brings the promise of quantitative imaging of the in-vivo distribution of any positron emitting nuclide, a list with hundreds of candidates. All but a few of these, the "pure positron" emitters, have isotropic coincident gamma rays that give rise to misrepresented events in the sinogram and in the resulting reconstructed image. Of particular interest are /sup 10/C, /sup 14/O, /sup 38/K, /sup 52m/Mn, /sup 60/Cu, /sup 61/Cu, /sup 94m/Tc, and /sup 124/I, each having high-energy gammas that are Compton-scattered down into the 511 keV window. The problems arising from the "third gamma," and its accommodation by standard scatter correction algorithms, were studied empirically, employing three scanner models (CTI 933/04, CTI HR+ and GE Advance), imaging three phantoms (line source, NEMA scatter and contrast/detail), with /sup 18/F or /sup 38/K and /sup 72/As mimicking /sup 14/O and /sup 10/C, respectively, in 2-D and 3-D modes. Five findings emerge directly from the image analysis. The third gamma: 1) does, obviously, tax the single event rate of the PET scanners, particularly in the absence of septa, from activity outside of the axial field of view; 2) does, therefore, tax the random rate, which is second order in singles, although the gamma is a prompt coincidence partner; 3) does enter the sinogram as an additional flat background, like randoms, but unlike scatter; 4) is not seriously misrepresented by the scatter algorithm which fits the correction to the wings of the sinogram; and 5) does introduce additional statistical noise from the subsequent subtraction, but does not seriously compromise the detectability of lesions as seen in the contrast/detail phantom. As a safeguard against the loss of accuracy in image quantitation, fiducial sources of known activity are included in the field of view alongside of the subject. With this precaution, a much wider selection of imaging agents can enjoy the advantages of positron emission tomography.

Ultrasonic Imaging System

NASA Technical Reports Server (NTRS)

Youngquist, Robert C. (Inventor); Moerk, Steven (Inventor)

1999-01-01

An imaging system is described which can be used to either passively search for sources of ultrasonics or as an active phase imaging system. which can image fires. gas leaks, or air temperature gradients. This system uses an array of ultrasonic receivers coupled to an ultrasound collector or lens to provide an electronic image of the ultrasound intensity in a selected angular region of space. A system is described which includes a video camera to provide a visual reference to a region being examined for ultrasonic signals.

IMAGES: An interactive image processing system

NASA Technical Reports Server (NTRS)

Jensen, J. R.

1981-01-01

The IMAGES interactive image processing system was created specifically for undergraduate remote sensing education in geography. The system is interactive, relatively inexpensive to operate, almost hardware independent, and responsive to numerous users at one time in a time-sharing mode. Most important, it provides a medium whereby theoretical remote sensing principles discussed in lecture may be reinforced in laboratory as students perform computer-assisted image processing. In addition to its use in academic and short course environments, the system has also been used extensively to conduct basic image processing research. The flow of information through the system is discussed including an overview of the programs.

Gamma ray camera

DOEpatents

Perez-Mendez, Victor

1997-01-01

A gamma ray camera for detecting rays emanating from a radiation source such as an isotope. The gamma ray camera includes a sensor array formed of a visible light crystal for converting incident gamma rays to a plurality of corresponding visible light photons, and a photosensor array responsive to the visible light photons in order to form an electronic image of the radiation therefrom. The photosensor array is adapted to record an integrated amount of charge proportional to the incident gamma rays closest to it, and includes a transparent metallic layer, photodiode consisting of a p-i-n structure formed on one side of the transparent metallic layer, and comprising an upper p-type layer, an intermediate layer and a lower n-type layer. In the preferred mode, the scintillator crystal is composed essentially of a cesium iodide (CsI) crystal preferably doped with a predetermined amount impurity, and the p-type upper intermediate layers and said n-type layer are essentially composed of hydrogenated amorphous silicon (a-Si:H). The gamma ray camera further includes a collimator interposed between the radiation source and the sensor array, and a readout circuit formed on one side of the photosensor array.

3D tomographic imaging with the γ-eye planar scintigraphic gamma camera

NASA Astrophysics Data System (ADS)

Tunnicliffe, H.; Georgiou, M.; Loudos, G. K.; Simcox, A.; Tsoumpas, C.

2017-11-01

γ-eye is a desktop planar scintigraphic gamma camera (100 mm × 50 mm field of view) designed by BET Solutions as an affordable tool for dynamic, whole body, small-animal imaging. This investigation tests the viability of using γ-eye for the collection of tomographic data for 3D SPECT reconstruction. Two software packages, QSPECT and STIR (software for tomographic image reconstruction), have been compared. Reconstructions have been performed using QSPECT’s implementation of the OSEM algorithm and STIR’s OSMAPOSL (Ordered Subset Maximum A Posteriori One Step Late) and OSSPS (Ordered Subsets Separable Paraboloidal Surrogate) algorithms. Reconstructed images of phantom and mouse data have been assessed in terms of spatial resolution, sensitivity to varying activity levels and uniformity. The effect of varying the number of iterations, the voxel size (1.25 mm default voxel size reduced to 0.625 mm and 0.3125 mm), the point spread function correction and the weight of prior terms were explored. While QSPECT demonstrated faster reconstructions, STIR outperformed it in terms of resolution (as low as 1 mm versus 3 mm), particularly when smaller voxel sizes were used, and in terms of uniformity, particularly when prior terms were used. Little difference in terms of sensitivity was seen throughout.

Gamma-ray imaging assay of cells 3-5 of the east cell line in the 235-F plutonium fuel form facility

DOE Office of Scientific and Technical Information (OSTI.GOV)

Brand, A. D.; Aucott, T. J.; Diprete, D. P.

In August and September, 2016, scientists from the Savannah River National Laboratory (SRNL) took a series of gamma-ray imaging measurements through the cell windows in front of Cells 3-5 on the east line of the Plutonium Fuel Form (PuFF) Facility using an electrically cooled, high-purity germanium detector. A Germanium Gamma Ray Imager (GeGI) was utilized since it allowed for the location from which the radiation was being emitted to be identified by incoming gamma-ray energy. This measurement technique provided a tool which allowed for the relative concentration of Pu-238 to be mapped throughout each cell. The mapping and new assaymore » data were then used to update the model used in an assay discussed in a 2014 report (SRNL-STI-2014-00629) and to calculate a more accurate value for the holdup in each of the cells [1]. Note that the mapping and new assay data did not replace the previous assay data in the model. Rather, the mapping and new assay data provided additional details on source distribution, which supplemented the previous assay data.« less

Ultrahigh resolution radiation imaging system using an optical fiber structure scintillator plate.

PubMed

Yamamoto, Seiichi; Kamada, Kei; Yoshikawa, Akira

2018-02-16

High resolution imaging of radiation is required for such radioisotope distribution measurements as alpha particle detection in nuclear facilities or high energy physics experiments. For this purpose, we developed an ultrahigh resolution radiation imaging system using an optical fiber structure scintillator plate. We used a ~1-μm diameter fiber structured GdAlO 3 :Ce (GAP) /α-Al 2 O 3 scintillator plate to reduce the light spread. The fiber structured scintillator plate was optically coupled to a tapered optical fiber plate to magnify the image and combined with a lens-based high sensitivity CCD camera. We observed the images of alpha particles with a spatial resolution of ~25 μm. For the beta particles, the images had various shapes, and the trajectories of the electrons were clearly observed in the images. For the gamma photons, the images also had various shapes, and the trajectories of the secondary electrons were observed in some of the images. These results show that combining an optical fiber structure scintillator plate with a tapered optical fiber plate and a high sensitivity CCD camera achieved ultrahigh resolution and is a promising method to observe the images of the interactions of radiation in a scintillator.

Breathing synchronized assessment of the chest hemodynamics: application to gamma and MR angiography

NASA Astrophysics Data System (ADS)

Eclancher, Bernard; Demangeat, Jean-Louis; Germain, Philippe; Baruthio, Joseph

2003-05-01

The project was to assess by gamma and MR angiography the bulk variations of chest blood volume related to deep and slow breathing movements. The acquisitions were performed at constant intervals on the widely moving system, without cardiac gating. Two fast enough modalities were used: a gamma-stethoscope working at 30 msec intervals for bulk volumic detection (of 99Tc labelled red cells), and MR imaging at 0.5 sec intervals well depicting displacements but not yet performing true angiography. The third modality yielding quantitative imaging was the scintillation gamma camera, but which required 30 sec signal acquisitions for each image. Frames were acquired at 1 sec intervals for up to 30 breathing cycles, and later sorted with double (inspiration and expiration) synchronization for the reconstruction of an average breathing cycle. Convergent results were obtained from the three angiographic modalities, confirming that the deep breathing movements produced inspiratory increases in bulk blood volume and caudal-median displacement of heart and great vessels, and expiratory decreases in blood volume and cranial-left displacement of heart and great vessels. Deep and slow breathing contributed effectively to thoracic blood pumping. The design of a 64x64 channels collimator has been undertaken to speed up the scintillation camera imaging acquisitions.

A High Current Tandem Accelerator for Gamma-Resonance Contraband Detection

NASA Astrophysics Data System (ADS)

Milton, Bruce

1997-05-01

TRIUMF and Northrop Grumman have developed a new system for the detection of concealed explosives and drugs. This Contraband Detection System (CDS) is based on the resonant absorption by ^14N of gammas produced using ^13C(p,γ)^14N. The chosen reaction uses protons at 1.75 MeV and the gammas have an energy of 9.17 MeV. By measuring both the resonant and the non -resonant absorption using detectors with good spatial resolution, and applying standard tomographic techniques, we are able to produce 3D images of both the nitrogen partial density and the total density. The images together may be utilized with considerable confidence to determine if small amounts of nitrogen based explosives, heroin or cocaine are present in the interrogated containers. Practical Gamma Resonant Absorption (GRA) scanning requires an intense source of protons. However this proton source must also be very stable, have low energy spread, and have good spatial definition. These demands suggested a tandem as the accelerator of choice. We have therefore constructed a 2 MeV H^- tandem optimized for high current (10 mA) operation, while minimizing the overall size of the accelerator. This has required several special innovations which will be presented in the paper. We will also present initial commissioning results.

Cone beam computed tomography image guidance system for a dedicated intracranial radiosurgery treatment unit.

PubMed

Ruschin, Mark; Komljenovic, Philip T; Ansell, Steve; Ménard, Cynthia; Bootsma, Gregory; Cho, Young-Bin; Chung, Caroline; Jaffray, David

2013-01-01

Image guidance has improved the precision of fractionated radiation treatment delivery on linear accelerators. Precise radiation delivery is particularly critical when high doses are delivered to complex shapes with steep dose gradients near critical structures, as is the case for intracranial radiosurgery. To reduce potential geometric uncertainties, a cone beam computed tomography (CT) image guidance system was developed in-house to generate high-resolution images of the head at the time of treatment, using a dedicated radiosurgery unit. The performance and initial clinical use of this imaging system are described. A kilovoltage cone beam CT system was integrated with a Leksell Gamma Knife Perfexion radiosurgery unit. The X-ray tube and flat-panel detector are mounted on a translational arm, which is parked above the treatment unit when not in use. Upon descent, a rotational axis provides 210° of rotation for cone beam CT scans. Mechanical integrity of the system was evaluated over a 6-month period. Subsequent clinical commissioning included end-to-end testing of targeting performance and subjective image quality performance in phantoms. The system has been used to image 2 patients, 1 of whom received single-fraction radiosurgery and 1 who received 3 fractions, using a relocatable head frame. Images of phantoms demonstrated soft tissue contrast visibility and submillimeter spatial resolution. A contrast difference of 35 HU was easily detected at a calibration dose of 1.2 cGy (center of head phantom). The shape of the mechanical flex vs scan angle was highly reproducible and exhibited <0.2 mm peak-to-peak variation. With a 0.5-mm voxel pitch, the maximum targeting error was 0.4 mm. Images of 2 patients were analyzed offline and submillimeter agreement was confirmed with conventional frame. A cone beam CT image guidance system was successfully adapted to a radiosurgery unit. The system is capable of producing high-resolution images of bone and soft tissue. The

Medical imaging systems

DOEpatents

Frangioni, John V

2013-06-25

A medical imaging system provides simultaneous rendering of visible light and diagnostic or functional images. The system may be portable, and may include adapters for connecting various light sources and cameras in open surgical environments or laparascopic or endoscopic environments. A user interface provides control over the functionality of the integrated imaging system. In one embodiment, the system provides a tool for surgical pathology.

Multiple-image oscilloscope camera

DOEpatents

Yasillo, Nicholas J.

1978-01-01

An optical device for placing automatically a plurality of images at selected locations on one film comprises a stepping motor coupled to a rotating mirror and lens. A mechanical connection from the mirror controls an electronic logical system to allow rotation of the mirror to place a focused image at the desired preselected location. The device is of especial utility when used to place four images on a single film to record oscilloscope views obtained in gamma radiography.

Iodine-131 imaging using 284 keV photons with a small animal CZT-SPECT system dedicated to low-medium-energy photon detection.

PubMed

Kojima, Akihiro; Gotoh, Kumiko; Shimamoto, Masako; Hasegawa, Koki; Okada, Seiji

2016-02-01

Iodine-131 is widely used for radionuclide therapy because of its β-particle and for diagnostic imaging employing its principal gamma ray. Since that principal gamma ray has the relatively high energy of 364 keV, small animal single-photon emission computed tomography (SPECT) imaging systems may be required to possess the ability to image such higher energy photons. The aim of this study was to investigate the possibility of imaging I-131 using its 284 keV photons instead of its 364 keV photons in a small animal SPECT imaging system dedicated to the detection of low-medium-energy photons (below 300 keV). The imaging system used was a commercially available preclinical SPECT instrument with CZT detectors that was equipped with multi-pinhole collimators and was accompanied by a CT imager. An energy window for I-131 imaging was set to a photopeak of 284 keV with a low abundance compared with 364 keV photons. Small line sources and two mice, one of each of two types, that were injected with NaI-131 were scanned. Although higher counts occurred at the peripheral region of the reconstructed images due to the collimator penetration by the 364 keV photons, the shape of the small line sources could be well visualized. The measured spatial resolution was relatively poor (~1.9 mm for full width at half maximum and ~3.9 mm for full width at tenth maximum). However, a good linear correlation between SPECT values and the level of I-131 radioactivity was observed. Furthermore, the uptake of NaI-131 to the thyroid gland for the two mice was clearly identified in the 3D-SPECT image fused with the X-ray CT image. We conclude that the use of an energy window set on the photopeak of 284 keV and the multi-pinhole collimator may permit I-131 imaging for a preclinical CZT-SPECT system that does not have the ability to acquire images using the 364 keV photons.

Motion correction for passive radiation imaging of small vessels in ship-to-ship inspections

DOE PAGES

Ziock, Klaus -Peter; Boehnen, Chris Bensing; Ernst, Joseph M.; ...

2015-09-05

Passive radiation detection remains one of the most acceptable means of ascertaining the presence of illicit nuclear materials. In maritime applications it is most effective against small to moderately sized vessels, where attenuation in the target vessel is of less concern. Unfortunately, imaging methods that can remove source confusion, localize a source, and avoid other systematic detection issues cannot be easily applied in ship-to-ship inspections because relative motion of the vessels blurs the results over many pixels, significantly reducing system sensitivity. This is particularly true for the smaller watercraft, where passive inspections are most valuable. We have developed a combinedmore » gamma-ray, stereo visible-light imaging system that addresses this problem. Data from the stereo imager are used to track the relative location and orientation of the target vessel in the field of view of a coded-aperture gamma-ray imager. Using this information, short-exposure gamma-ray images are projected onto the target vessel using simple tomographic back-projection techniques, revealing the location of any sources within the target. Here,the complex autonomous tracking and image reconstruction system runs in real time on a 48-core workstation that deploys with the system.« less

Polarimetric Analysis of the Long Duration Gamma-Ray Burst GRB 160530A With the Balloon Borne Compton Spectrometer and Imager

NASA Astrophysics Data System (ADS)

Lowell, A. W.; Boggs, S. E.; Chiu, C. L.; Kierans, C. A.; Sleator, C.; Tomsick, J. A.; Zoglauer, A. C.; Chang, H.-K.; Tseng, C.-H.; Yang, C.-Y.; Jean, P.; von Ballmoos, P.; Lin, C.-H.; Amman, M.

2017-10-01

A long duration gamma-ray burst, GRB 160530A, was detected by the Compton Spectrometer and Imager (COSI) during the 2016 COSI Super Pressure Balloon campaign. As a Compton telescope, COSI is inherently sensitive to the polarization of gamma-ray sources in the energy range 0.2-5.0 MeV. We measured the polarization of GRB 160530A using (1) a standard method (SM) based on fitting the distribution of azimuthal scattering angles with a modulation curve and (2) an unbinned, maximum likelihood method (MLM). In both cases, the measured polarization level was below the 99% confidence minimum detectable polarization levels of 72.3% ± 0.8% (SM) and 57.5% ± 0.8% (MLM). Therefore, COSI did not detect polarized gamma-ray emission from this burst. Our most constraining 90% confidence upper limit on the polarization level was 46% (MLM).

Prompt-gamma monitoring in hadrontherapy: A review

NASA Astrophysics Data System (ADS)

Krimmer, J.; Dauvergne, D.; Létang, J. M.; Testa, É.

2018-01-01

Secondary radiation emission induced by nuclear reactions is correlated to the path of ions in matter. Therefore, such penetrating radiation can be used for in vivo control of hadrontherapy treatments, for which the primary beam is absorbed inside the patient. Among secondary radiations, prompt-gamma rays were proposed for real-time verification of ion range. Such a verification is a desired condition to reduce uncertainties in treatment planning. For more than a decade, efforts have been undertaken worldwide to promote prompt-gamma-based devices to be used in clinical conditions. Dedicated cameras are necessary to overcome the challenges of a broad- and high-energy distribution, a large background, high instantaneous count rates, and compatibility constraints with patient irradiation. Several types of prompt-gamma imaging devices have been proposed, that are either physically-collimated or electronically collimated (Compton cameras). Clinical tests are now undergoing. Meanwhile, other methods than direct prompt-gamma imaging were proposed, that are based on specific counting using either time-of-flight or photon energy measurements. In the present article, we make a review and discuss the state of the art for all techniques using prompt-gamma detection to improve the quality assurance in hadrontherapy.

Dual-energy imaging method to improve the image quality and the accuracy of dose calculation for cone-beam computed tomography.

PubMed

Men, Kuo; Dai, Jianrong; Chen, Xinyuan; Li, Minghui; Zhang, Ke; Huang, Peng

2017-04-01

To improve the image quality and accuracy of dose calculation for cone-beam computed tomography (CT) images through implementation of a dual-energy cone-beam computed tomography method (DE-CBCT), and evaluate the improvement quantitatively. Two sets of CBCT projections were acquired using the X-ray volumetric imaging (XVI) system on a Synergy (Elekta, Stockholm, Sweden) system with 120kV (high) and 70kV (low) X-rays, respectively. Then, the electron density relative to water (relative electron density (RED)) of each voxel was calculated using a projection-based dual-energy decomposition method. As a comparison, single-energy cone-beam computed tomography (SE-CBCT) was used to calculate RED with the Hounsfield unit-RED calibration curve generated by a CIRS phantom scan with identical imaging parameters. The imaging dose was measured with a dosimetry phantom. The image quality was evaluated quantitatively using a Catphan 503 phantom with the evaluation indices of the reproducibility of the RED values, high-contrast resolution (MTF 50% ), uniformity, and signal-to-noise ratio (SNR). Dose calculation of two simulated volumetric-modulated arc therapy plans using an Eclipse treatment-planning system (Varian Medical Systems, Palo Alto, CA, USA) was performed on an Alderson Rando Head and Neck (H&N) phantom and a Pelvis phantom. Fan-beam planning CT images for the H&N and Pelvis phantom were set as the reference. A global three-dimensional gamma analysis was used to compare dose distributions with the reference. The average gamma values for targets and OAR were analyzed with paired t-tests between DE-CBCT and SE-CBCT. In two scans (H&N scan and body scan), the imaging dose of DE-CBCT increased by 1.0% and decreased by 1.3%. It had a better reproducibility of the RED values (mean bias: 0.03 and 0.07) compared with SE-CBCT (mean bias: 0.13 and 0.16). It also improved the image uniformity (57.5% and 30.1%) and SNR (9.7% and 2.3%), but did not affect the MTF 50% . Gamma

Single-view 3D reconstruction of correlated gamma-neutron sources

DOE PAGES

Monterial, Mateusz; Marleau, Peter; Pozzi, Sara A.

2017-01-05

We describe a new method of 3D image reconstruction of neutron sources that emit correlated gammas (e.g. Cf- 252, Am-Be). This category includes a vast majority of neutron sources important in nuclear threat search, safeguards and non-proliferation. Rather than requiring multiple views of the source this technique relies on the source’s intrinsic property of coincidence gamma and neutron emission. As a result only a single-view measurement of the source is required to perform the 3D reconstruction. In principle, any scatter camera sensitive to gammas and neutrons with adequate timing and interaction location resolution can perform this reconstruction. Using a neutronmore » double scatter technique, we can calculate a conical surface of possible source locations. By including the time to a correlated gamma we further constrain the source location in three-dimensions by solving for the source-to-detector distance along the surface of said cone. As a proof of concept we applied these reconstruction techniques on measurements taken with the the Mobile Imager of Neutrons for Emergency Responders (MINER). Two Cf-252 sources measured at 50 and 60 cm from the center of the detector were resolved in their varying depth with average radial distance relative resolution of 26%. To demonstrate the technique’s potential with an optimized system we simulated the measurement in MCNPX-PoliMi assuming timing resolution of 200 ps (from 2 ns in the current system) and source interaction location resolution of 5 mm (from 3 cm). Furthermore, these simulated improvements in scatter camera performance resulted in radial distance relative resolution decreasing to an average of 11%.« less

Single-view 3D reconstruction of correlated gamma-neutron sources

DOE Office of Scientific and Technical Information (OSTI.GOV)

Monterial, Mateusz; Marleau, Peter; Pozzi, Sara A.

We describe a new method of 3D image reconstruction of neutron sources that emit correlated gammas (e.g. Cf- 252, Am-Be). This category includes a vast majority of neutron sources important in nuclear threat search, safeguards and non-proliferation. Rather than requiring multiple views of the source this technique relies on the source’s intrinsic property of coincidence gamma and neutron emission. As a result only a single-view measurement of the source is required to perform the 3D reconstruction. In principle, any scatter camera sensitive to gammas and neutrons with adequate timing and interaction location resolution can perform this reconstruction. Using a neutronmore » double scatter technique, we can calculate a conical surface of possible source locations. By including the time to a correlated gamma we further constrain the source location in three-dimensions by solving for the source-to-detector distance along the surface of said cone. As a proof of concept we applied these reconstruction techniques on measurements taken with the the Mobile Imager of Neutrons for Emergency Responders (MINER). Two Cf-252 sources measured at 50 and 60 cm from the center of the detector were resolved in their varying depth with average radial distance relative resolution of 26%. To demonstrate the technique’s potential with an optimized system we simulated the measurement in MCNPX-PoliMi assuming timing resolution of 200 ps (from 2 ns in the current system) and source interaction location resolution of 5 mm (from 3 cm). Furthermore, these simulated improvements in scatter camera performance resulted in radial distance relative resolution decreasing to an average of 11%.« less

Applying the new gamma ray imager diagnostic to measurements of runaway electron Bremsstrahlung radiation in the DIII-D Tokamak (invited)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cooper, C. M., E-mail: coopercm@fusion.gat.com; Pace, D. C.; Paz-Soldan, C.

2016-11-15

A new gamma ray imager (GRI) is developed to probe the electron distribution function with 2D spatial resolution during runaway electron (RE) experiments at the DIII-D tokamak. The diagnostic is sensitive to 0.5–100 MeV gamma rays, allowing characterization of the RE distribution function evolution during RE growth and dissipation. The GRI consists of a lead “pinhole camera” mounted on the DIII-D midplane with 123 honeycombed tangential chords 20 cm wide that span the vessel interior. Up to 30 bismuth germanate (BGO) scintillation detectors capture RE bremsstrahlung radiation for Pulse Height Analysis (PHA) capable of discriminating up to 20 000 pulses permore » second. Digital signal processing routines combining shaping filters are performed during PHA to reject noise and record gamma ray energy. The GRI setup and PHA algorithms will be described and initial data from experiments will be presented. A synthetic diagnostic is developed to generate the gamma ray spectrum of a GRI channel given the plasma information and a prescribed distribution function. Magnetic reconstructions of the plasma are used to calculate the angle between every GRI sightline and orient and discriminate gamma rays emitted by a field-aligned RE distribution function.« less

Applying the new gamma ray imager diagnostic to measurements of runaway electron Bremsstrahlung radiation in the DIII-D Tokamak (invited)

DOE PAGES

Cooper, C. M.; Pace, D. C.; Paz-Soldan, C.; ...

2016-08-30

A new gamma ray imager (GRI) is developed to probe the electron distribution function with 2D spatial resolution during runaway electron (RE) experiments at the DIII-D tokamak. The diagnostic is sensitive to 0.5-100 MeV gamma rays, allowing characterization of the RE distribution function evolution during RE growth and dissipation. The GRI consists of a lead "pinhole camera" mounted on the DIII-D midplane with 123 honeycombed tangential chords 20 cm wide that span the vessel interior. Up to 30 bismuth germanate (BGO) scintillation detectors capture RE bremsstrahlung radiation for Pulse Height Analysis (PHA) capable of discriminating up to 20,000 pulses permore » second. Digital signal processing routines combining shaping filters are performed during PHA to reject noise and record gamma ray energy. The GRI setup and PHA algorithms will be described and initial data from experiments will be presented. A synthetic diagnostic is developed to generate the gamma ray spectrum of a GRI channel given the plasma information and a prescribed distribution function. Furthermore, magnetic reconstructions of the plasma are used to calculate the angle between every GRI sightline and orient and discriminate gamma rays emitted by a field-aligned RE distribution function.« less

Gammapy: Python toolbox for gamma-ray astronomy

NASA Astrophysics Data System (ADS)

Deil, Christoph; Donath, Axel; Owen, Ellis; Terrier, Regis; Bühler, Rolf; Armstrong, Thomas

2017-11-01

Gammapy analyzes gamma-ray data and creates sky images, spectra and lightcurves, from event lists and instrument response information; it can also determine the position, morphology and spectra of gamma-ray sources. It is used to analyze data from H.E.S.S., Fermi-LAT, and the Cherenkov Telescope Array (CTA).

An alpha–gamma coincidence spectrometer based on the Photon–Electron Rejecting Alpha Liquid Scintillation (PERALS®) system

DOE PAGES

Cadieux, J. R.; Fugate, G. A.; King, III, G. S.

2015-02-07

Here, an alpha–gamma coincidence spectrometer has been developed for the measurement of selected actinide isotopes in the presence of high beta/gamma fields. The system is based on a PERALS® liquid scintillation counter for beta/alpha discrimination and was successfully tested with both high purity germanium and bismuth germanate, gamma-ray detectors using conventional analog electronics.

The Gamma-ray Sky with Fermi

NASA Technical Reports Server (NTRS)

Thompson, David

2012-01-01

Gamma rays reveal extreme, nonthermal conditions in the Universe. The Fermi Gamma-ray Space Telescope has been exploring the gamma-ray sky for more than four years, enabling a search for powerful transients like gamma-ray bursts, novae, solar flares, and flaring active galactic nuclei, as well as long-term studies including pulsars, binary systems, supernova remnants, and searches for predicted sources of gamma rays such as dark matter annihilation. Some results include a stringent limit on Lorentz invariance derived from a gamma-ray burst, unexpected gamma-ray variability from the Crab Nebula, a huge gamma-ray structure associated with the center of our galaxy, surprising behavior from some gamma-ray binary systems, and a possible constraint on some WIMP models for dark matter.

Image Processing System

NASA Technical Reports Server (NTRS)

1986-01-01

Mallinckrodt Institute of Radiology (MIR) is using a digital image processing system which employs NASA-developed technology. MIR's computer system is the largest radiology system in the world. It is used in diagnostic imaging. Blood vessels are injected with x-ray dye, and the images which are produced indicate whether arteries are hardened or blocked. A computer program developed by Jet Propulsion Laboratory known as Mini-VICAR/IBIS was supplied to MIR by COSMIC. The program provides the basis for developing the computer imaging routines for data processing, contrast enhancement and picture display.

Cardiac Imaging System

NASA Technical Reports Server (NTRS)

1990-01-01

Although not available to all patients with narrowed arteries, balloon angioplasty has expanded dramatically since its introduction with an estimated further growth to 562,000 procedures in the U.S. alone by 1992. Growth has fueled demand for higher quality imaging systems that allow the cardiologist to be more accurate and increase the chances of a successful procedure. A major advance is the Digital Cardiac Imaging (DCI) System designed by Philips Medical Systems International, Best, The Netherlands and marketed in the U.S. by Philips Medical Systems North America Company. The key benefit is significantly improved real-time imaging and the ability to employ image enhancement techniques to bring out added details. Using a cordless control unit, the cardiologist can manipulate images to make immediate assessment, compare live x-ray and roadmap images by placing them side-by-side on monitor screens, or compare pre-procedure and post procedure conditions. The Philips DCI improves the cardiologist's precision by expanding the information available to him.

Observation of gamma ray bursts and flares by the EGRET telescope on the Compton Gamma Ray Observatory

NASA Technical Reports Server (NTRS)

Schneid, E. J.; Bertsch, D. L.; Fichtel, C. E.; Hartman, R. C.; Hunter, S. D.; Kwok, P. W.; Mattox, J. R.; Sreekumar, P.; Thompson, D. J.; Kanbach, G.

1992-01-01

The Energetic Gamma Ray Experiment Telescope (EGRET) on the Compton Gamma Ray Observatory has observed energetic gamma ray bursts and flares. On May 3, 1991, EGRET detected a gamma ray burst both in the energy measuring NaI (Tl) scintillator and independently in the spark chamber imaging assembly. The NaI spectra were accumulated by a special BURST mode of EGRET. The spectra were measured over a range from 1 to 200 MeV, in three sequential spectra of 1,2, and 4 seconds. During the peak of the burst, six individual gamma rays were detected in the spark chamber, allowing a determination of the burst arrival direction. The intense flares of June were also detected. A solar flare on June 4 was observed to last for several minutes and for a brief time, less than a minute, had significant emission of gamma rays exceeding 150 MeV.

Multipurpose Hyperspectral Imaging System

NASA Technical Reports Server (NTRS)

Mao, Chengye; Smith, David; Lanoue, Mark A.; Poole, Gavin H.; Heitschmidt, Jerry; Martinez, Luis; Windham, William A.; Lawrence, Kurt C.; Park, Bosoon

2005-01-01

A hyperspectral imaging system of high spectral and spatial resolution that incorporates several innovative features has been developed to incorporate a focal plane scanner (U.S. Patent 6,166,373). This feature enables the system to be used for both airborne/spaceborne and laboratory hyperspectral imaging with or without relative movement of the imaging system, and it can be used to scan a target of any size as long as the target can be imaged at the focal plane; for example, automated inspection of food items and identification of single-celled organisms. The spectral resolution of this system is greater than that of prior terrestrial multispectral imaging systems. Moreover, unlike prior high-spectral resolution airborne and spaceborne hyperspectral imaging systems, this system does not rely on relative movement of the target and the imaging system to sweep an imaging line across a scene. This compact system (see figure) consists of a front objective mounted at a translation stage with a motorized actuator, and a line-slit imaging spectrograph mounted within a rotary assembly with a rear adaptor to a charged-coupled-device (CCD) camera. Push-broom scanning is carried out by the motorized actuator which can be controlled either manually by an operator or automatically by a computer to drive the line-slit across an image at a focal plane of the front objective. To reduce the cost, the system has been designed to integrate as many as possible off-the-shelf components including the CCD camera and spectrograph. The system has achieved high spectral and spatial resolutions by using a high-quality CCD camera, spectrograph, and front objective lens. Fixtures for attachment of the system to a microscope (U.S. Patent 6,495,818 B1) make it possible to acquire multispectral images of single cells and other microscopic objects.

Gamma ray camera

DOEpatents

Perez-Mendez, V.

1997-01-21

A gamma ray camera is disclosed for detecting rays emanating from a radiation source such as an isotope. The gamma ray camera includes a sensor array formed of a visible light crystal for converting incident gamma rays to a plurality of corresponding visible light photons, and a photosensor array responsive to the visible light photons in order to form an electronic image of the radiation therefrom. The photosensor array is adapted to record an integrated amount of charge proportional to the incident gamma rays closest to it, and includes a transparent metallic layer, photodiode consisting of a p-i-n structure formed on one side of the transparent metallic layer, and comprising an upper p-type layer, an intermediate layer and a lower n-type layer. In the preferred mode, the scintillator crystal is composed essentially of a cesium iodide (CsI) crystal preferably doped with a predetermined amount impurity, and the p-type upper intermediate layers and said n-type layer are essentially composed of hydrogenated amorphous silicon (a-Si:H). The gamma ray camera further includes a collimator interposed between the radiation source and the sensor array, and a readout circuit formed on one side of the photosensor array. 6 figs.

Search for TeV gamma ray emission from the Andromeda galaxy

NASA Astrophysics Data System (ADS)

Aharonian, F. A.; Akhperjanian, A. G.; Beilicke, M.; Bernlöhr, K.; Bojahr, H.; Bolz, O.; Börst, H.; Coarasa, T.; Contreras, J. L.; Cortina, J.; Denninghoff, S.; Fonseca, V.; Girma, M.; Götting, N.; Heinzelmann, G.; Hermann, G.; Heusler, A.; Hofmann, W.; Horns, D.; Jung, I.; Kankanyan, R.; Kestel, M.; Kettler, J.; Kohnle, A.; Konopelko, A.; Kornmeyer, H.; Kranich, D.; Krawczynski, H.; Lampeitl, H.; Lopez, M.; Lorenz, E.; Lucarelli, F.; Mang, O.; Meyer, H.; Mirzoyan, R.; Moralejo, A.; Ona, E.; Panter, M.; Plyasheshnikov, A.; Pühlhofer, G.; Rauterberg, G.; Reyes, R.; Rhode, W.; Ripken, J.; Röhring, A.; Rowell, G. P.; Sahakian, V.; Samorski, M.; Schilling, M.; Siems, M.; Sobzynska, D.; Stamm, W.; Tluczykont, M.; Völk, H. J.; Wiedner, C. A.; Wittek, W.

2003-03-01

Using the HEGRA system of imaging atmospheric Cherenkov telescopes, the Andromeda galaxy (M 31) was surveyed for TeV gamma ray emission. Given the large field of view of the HEGRA telescopes, three pointings were sufficient to cover all of M 31, including also M 32 and NGC 205. No indications for point sources of TeV gamma rays were found. Upper limits are given at a level of a few percent of the Crab flux. A specific search for monoenergetic gamma-ray lines from annihilation of supersymmetric dark matter particles accumulating near the center of M 31 resulted in flux limits in the 10-13 cm-2 s-1 range, well above the predicted MSSM flux levels except for models with pronounced dark-matter spikes or strongly enhanced annihilation rates.

Polarimetric Analysis of the Long Duration Gamma-Ray Burst GRB 160530A With the Balloon Borne Compton Spectrometer and Imager

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lowell, A. W.; Boggs, S. E; Chiu, C. L.

2017-10-20

A long duration gamma-ray burst, GRB 160530A, was detected by the Compton Spectrometer and Imager (COSI) during the 2016 COSI Super Pressure Balloon campaign. As a Compton telescope, COSI is inherently sensitive to the polarization of gamma-ray sources in the energy range 0.2–5.0 MeV. We measured the polarization of GRB 160530A using (1) a standard method (SM) based on fitting the distribution of azimuthal scattering angles with a modulation curve and (2) an unbinned, maximum likelihood method (MLM). In both cases, the measured polarization level was below the 99% confidence minimum detectable polarization levels of 72.3% ± 0.8% (SM) andmore » 57.5% ± 0.8% (MLM). Therefore, COSI did not detect polarized gamma-ray emission from this burst. Our most constraining 90% confidence upper limit on the polarization level was 46% (MLM).« less

Development and calibration of a new gamma camera detector using large square Photomultiplier Tubes

NASA Astrophysics Data System (ADS)

Zeraatkar, N.; Sajedi, S.; Teimourian Fard, B.; Kaviani, S.; Akbarzadeh, A.; Farahani, M. H.; Sarkar, S.; Ay, M. R.

2017-09-01

Large area scintillation detectors applied in gamma cameras as well as Single Photon Computed Tomography (SPECT) systems, have a major role in in-vivo functional imaging. Most of the gamma detectors utilize hexagonal arrangement of Photomultiplier Tubes (PMTs). In this work we applied large square-shaped PMTs with row/column arrangement and positioning. The Use of large square PMTs reduces dead zones in the detector surface. However, the conventional center of gravity method for positioning may not introduce an acceptable result. Hence, the digital correlated signal enhancement (CSE) algorithm was optimized to obtain better linearity and spatial resolution in the developed detector. The performance of the developed detector was evaluated based on NEMA-NU1-2007 standard. The acquired images using this method showed acceptable uniformity and linearity comparing to three commercial gamma cameras. Also the intrinsic and extrinsic spatial resolutions with low-energy high-resolution (LEHR) collimator at 10 cm from surface of the detector were 3.7 mm and 7.5 mm, respectively. The energy resolution of the camera was measured 9.5%. The performance evaluation demonstrated that the developed detector maintains image quality with a reduced number of used PMTs relative to the detection area.